Integrated operations plan for the MFTF-B Mirror Fusion Test Facility. Volume I. Organization plan

International Nuclear Information System (INIS)

1981-12-01

This plan and the accompanying MFTF-B Integrated Operations Plan are submitted in response to UC/LLNL Purchase Order 3883801, dated July 1981. The organization plan also addresses the specific tasks and trade studies directed by the scope of work. The Integrated Operations Plan, which includes a reliability, quality assurance, and safety plan and an integrated logistics plan, comprises the burden of the report. In the first section of this volume, certain underlying assumptions and observations are discussed setting the requirements and limits for organization. Section B presents the recommended structure itself. Section C Device Availability vs Maintenance and Support Efforts and Section D Staffing Levels and Skills provide backup detail and justification. Section E is a trade study on maintenance and support by LLNL staff vs subcontract and Section F is a plan for transitioning from the construction phase into operation. A brief summary of schedules and estimated costs concludes the volume

Verification and validation guidelines for high integrity systems. Volume 1

Energy Technology Data Exchange (ETDEWEB)

Hecht, H.; Hecht, M.; Dinsmore, G.; Hecht, S.; Tang, D. [SoHaR, Inc., Beverly Hills, CA (United States)

1995-03-01

High integrity systems include all protective (safety and mitigation) systems for nuclear power plants, and also systems for which comparable reliability requirements exist in other fields, such as in the process industries, in air traffic control, and in patient monitoring and other medical systems. Verification aims at determining that each stage in the software development completely and correctly implements requirements that were established in a preceding phase, while validation determines that the overall performance of a computer system completely and correctly meets system requirements. Volume I of the report reviews existing classifications for high integrity systems and for the types of errors that may be encountered, and makes recommendations for verification and validation procedures, based on assumptions about the environment in which these procedures will be conducted. The final chapter of Volume I deals with a framework for standards in this field. Volume II contains appendices dealing with specific methodologies for system classification, for dependability evaluation, and for two software tools that can automate otherwise very labor intensive verification and validation activities.

Verification and validation guidelines for high integrity systems. Volume 1

International Nuclear Information System (INIS)

Hecht, H.; Hecht, M.; Dinsmore, G.; Hecht, S.; Tang, D.

1995-03-01

High integrity systems include all protective (safety and mitigation) systems for nuclear power plants, and also systems for which comparable reliability requirements exist in other fields, such as in the process industries, in air traffic control, and in patient monitoring and other medical systems. Verification aims at determining that each stage in the software development completely and correctly implements requirements that were established in a preceding phase, while validation determines that the overall performance of a computer system completely and correctly meets system requirements. Volume I of the report reviews existing classifications for high integrity systems and for the types of errors that may be encountered, and makes recommendations for verification and validation procedures, based on assumptions about the environment in which these procedures will be conducted. The final chapter of Volume I deals with a framework for standards in this field. Volume II contains appendices dealing with specific methodologies for system classification, for dependability evaluation, and for two software tools that can automate otherwise very labor intensive verification and validation activities

Life sciences payload definition and integration study, task C and D. Volume 2: Payload definition, integration, and planning studies

Science.gov (United States)

1973-01-01

The Life Sciences Payload Definition and Integration Study was composed of four major tasks. Tasks A and B, the laboratory definition phase, were the subject of prior NASA study. The laboratory definition phase included the establishment of research functions, equipment definitions, and conceptual baseline laboratory designs. These baseline laboratories were designated as Maxi-Nom, Mini-30, and Mini-7. The outputs of Tasks A and B were used by the NASA Life Sciences Payload Integration Team to establish guidelines for Tasks C and D, the laboratory integration phase of the study. A brief review of Tasks A and B is presented provide background continuity. The tasks C and D effort is the subject of this report. The Task C effort stressed the integration of the NASA selected laboratory designs with the shuttle sortie module. The Task D effort updated and developed costs that could be used by NASA for preliminary program planning.

Lattice study of finite volume effect in HVP for muon g-2

Directory of Open Access Journals (Sweden)

Izubuchi Taku

2018-01-01

Full Text Available We study the finite volume effect of the hadronic vacuum polarization contribution to muon g-2, aμhvp,in lattice QCD by comparison with two different volumes, L4 = (5.44 and (8.14 fm4, at physical pion. We perform the lattice computation of highly precise vector-vector current correlator with optimized AMA technique on Nf = 2 + 1 PACS gauge configurations in Wilson-clover fermion and stout smeared gluon action at one lattice cut-off, a−1 = 2.33 GeV. We compare two integrals of aμhvp, momentum integral and time-slice summation, on the lattice and numerically show that the different size of finite volume effect appears between two methods. We also discuss the effect of backward-state propagation into the result of aμhvp with the different boundary condition. Our model-independent study suggest that the lattice computation at physical pion is important for correct estimate of finite volume and other lattice systematics in aμhvp.

Lattice study of finite volume effect in HVP for muon g-2

Science.gov (United States)

Izubuchi, Taku; Kuramashi, Yoshinobu; Lehner, Christoph; Shintani, Eigo

2018-03-01

We study the finite volume effect of the hadronic vacuum polarization contribution to muon g-2, aμhvp, in lattice QCD by comparison with two different volumes, L4 = (5.4)4 and (8.1)4 fm4, at physical pion. We perform the lattice computation of highly precise vector-vector current correlator with optimized AMA technique on Nf = 2 + 1 PACS gauge configurations in Wilson-clover fermion and stout smeared gluon action at one lattice cut-off, a-1 = 2.33 GeV. We compare two integrals of aμhvp, momentum integral and time-slice summation, on the lattice and numerically show that the different size of finite volume effect appears between two methods. We also discuss the effect of backward-state propagation into the result of aμhvp with the different boundary condition. Our model-independent study suggest that the lattice computation at physical pion is important for correct estimate of finite volume and other lattice systematics in aμhvp.

IEA Wind Task 24 Integration of Wind and Hydropower Systems; Volume 1: Issues, Impacts, and Economics of Wind and Hydropower Integration

Energy Technology Data Exchange (ETDEWEB)

Acker, T.

2011-12-01

This report describes the background, concepts, issues and conclusions related to the feasibility of integrating wind and hydropower, as investigated by the members of IEA Wind Task 24. It is the result of a four-year effort involving seven IEA member countries and thirteen participating organizations. The companion report, Volume 2, describes in detail the study methodologies and participant case studies, and exists as a reference for this report.

Portable waveguide display system with a large field of view by integrating freeform elements and volume holograms.

Science.gov (United States)

Han, Jian; Liu, Juan; Yao, Xincheng; Wang, Yongtian

2015-02-09

A compact waveguide display system integrating freeform elements and volume holograms is presented here for the first time. The use of freeform elements can broaden the field of view, which limits the applications of a holographic waveguide. An optimized system can achieve a diagonal field of view of 45° when the thickness of the waveguide planar is 3mm. Freeform-elements in-coupler and the volume holograms out-coupler were designed in detail in our study, and the influence of grating configurations on diffraction efficiency was analyzed thoroughly. The off-axis aberrations were well compensated by the in-coupler and the diffraction efficiency of the optimized waveguide display system could reach 87.57%. With integrated design, stability and reliability of this monochromatic display system were achieved and the alignment of the system was easily controlled by the record of the volume holograms, which makes mass production possible.

An efficient explicit marching on in time solver for magnetic field volume integral equation

KAUST Repository

Sayed, Sadeed Bin; Ulku, H. Arda; Bagci, Hakan

2015-01-01

An efficient explicit marching on in time (MOT) scheme for solving the magnetic field volume integral equation is proposed. The MOT system is cast in the form of an ordinary differential equation and is integrated in time using a PE(CE)m multistep

European market integration for gas? Volume flexibility and political risk

International Nuclear Information System (INIS)

Asche, Frank; Tveteras, Ragnar; Osmundsen, Petter

2002-01-01

Long-term take-or-pay contracts regulating gas exports to the Continent are described and analyzed. We thereafter examine whether the German gas market is integrated. Time series of Norwegian, Dutch and Russian gas export prices to Germany in 1990-1998 are examined. Cointegration tests show that that the different border prices for gas to Germany move proportionally over time, indicating an integrated gas market. We find differences in mean prices, with Russian gas being sold at prices systematically lower than Dutch and Norwegian gas. Among the explanatory factors for price discrepancies are differences in volume flexibility (swing) and perceived political risk

Iterative algorithm for the volume integral method for magnetostatics problems

International Nuclear Information System (INIS)

Pasciak, J.E.

1980-11-01

Volume integral methods for solving nonlinear magnetostatics problems are considered in this paper. The integral method is discretized by a Galerkin technique. Estimates are given which show that the linearized problems are well conditioned and hence easily solved using iterative techniques. Comparisons of iterative algorithms with the elimination method of GFUN3D shows that the iterative method gives an order of magnitude improvement in computational time as well as memory requirements for large problems. Computational experiments for a test problem as well as a double layer dipole magnet are given. Error estimates for the linearized problem are also derived

Mars power system concept definition study. Volume 1: Study results

Science.gov (United States)

Littman, Franklin D.

1994-01-01

A preliminary top level study was completed to define power system concepts applicable to Mars surface applications. This effort included definition of power system requirements and selection of power systems with the potential for high commonality. These power systems included dynamic isotope, Proton Exchange Membrane (PEM) regenerative fuel cell, sodium sulfur battery, photovoltaic, and reactor concepts. Design influencing factors were identified. Characterization studies were then done for each concept to determine system performance, size/volume, and mass. Operations studies were done to determine emplacement/deployment maintenance/servicing, and startup/shutdown requirements. Technology development roadmaps were written for each candidate power system (included in Volume 2). Example power system architectures were defined and compared on a mass basis. The dynamic isotope power system and nuclear reactor power system architectures had significantly lower total masses than the photovoltaic system architectures. Integrated development and deployment time phasing plans were completed for an example DIPS and reactor architecture option to determine the development strategies required to meet the mission scenario requirements.

Blood volume studies

International Nuclear Information System (INIS)

Lewis, S.M.; Yin, J.A.L.

1986-01-01

The use of dilution analysis with such radioisotopes as 51 Cr, 32 P, sup(99m)Tc and sup(113m)In for measuring red cell volume is reviewed briefly. The use of 125 I and 131 I for plasma volume studies is also considered and the subsequent determination of total blood volume discussed, together with the role of the splenic red cell volume. Substantial bibliography. (UK)

Hemorrhagic shock impairs myocardial cell volume regulation and membrane integrity in dogs

International Nuclear Information System (INIS)

Horton, J.W.

1987-01-01

An in vitro myocardial slice technique was used to quantitate alterations in cell volume regulation and membrane integrity after 2 h or hemorrhagic shock. After in vitro incubation in Krebs-Ringer-phosphate medium containing trace [ 14 C]inulin, values (ml H 2 O/g dry wt) for control nonshocked myocardial slices were 4.03 /plus minus/ 0.11 (SE) for total water, 2.16 /plus minus/ 0.07 for inulin impermeable space, and 1.76 /plus minus/ 0.15 for inulin diffusible space. Shocked myocardial slices showed impaired response to cold incubation. After 2 h of in vivo shock, total tissue water, inulin diffusible space, and inulin impermeable space increased significantly for subendocardium, whereas changes in subepicardium parameters were minimal. Shock-induced cellular swelling was accompanied by an increased total tissue sodium, but no change in tissue potassium. Calcium entry blockade in vivo significantly reduced subendocardial total tissue water as compared with shock-untreated dogs. In addition, calcium entry blockade reduced shock-induced increases in inulin diffusible space. In vitro myocardial slice studies confirm alterations in subendocardial membrane integrity after 2 h of in vivo hemorrhagic shock. Shock-induced abnormalities in myocardial cell volume regulation are reduced by calcium entry blockade in vivo

Integrated nonthermal treatment system study

International Nuclear Information System (INIS)

Biagi, C.; Bahar, D.; Teheranian, B.; Vetromile, J.; Quapp, W.J.; Bechtold, T.; Brown, B.; Schwinkendorf, W.; Swartz, G.

1997-01-01

This report presents the results of a study of nonthermal treatment technologies. The study consisted of a systematic assessment of five nonthermal treatment alternatives. The treatment alternatives consist of widely varying technologies for safely destroying the hazardous organic components, reducing the volume, and preparing for final disposal of the contact-handled mixed low-level waste (MLLW) currently stored in the US Department of Energy complex. The alternatives considered were innovative nonthermal treatments for organic liquids and sludges, process residue, soil and debris. Vacuum desorption or various washing approaches are considered for treatment of soil, residue and debris. Organic destruction methods include mediated electrochemical oxidation, catalytic wet oxidation, and acid digestion. Other methods studied included stabilization technologies and mercury separation of treatment residues. This study is a companion to the integrated thermal treatment study which examined 19 alternatives for thermal treatment of MLLW waste. The quantities and physical and chemical compositions of the input waste are based on the inventory database developed by the US Department of Energy. The Integrated Nonthermal Treatment Systems (INTS) systems were evaluated using the same waste input (2,927 pounds per hour) as the Integrated Thermal Treatment Systems (ITTS). 48 refs., 68 figs., 37 tabs

Integrated nonthermal treatment system study

Energy Technology Data Exchange (ETDEWEB)

Biagi, C.; Bahar, D.; Teheranian, B.; Vetromile, J. [Morrison Knudsen Corp. (United States); Quapp, W.J. [Nuclear Metals (United States); Bechtold, T.; Brown, B.; Schwinkendorf, W. [Lockheed Martin Idaho Technologies Co., Idaho Falls, ID (United States); Swartz, G. [Swartz and Associates (United States)

1997-01-01

This report presents the results of a study of nonthermal treatment technologies. The study consisted of a systematic assessment of five nonthermal treatment alternatives. The treatment alternatives consist of widely varying technologies for safely destroying the hazardous organic components, reducing the volume, and preparing for final disposal of the contact-handled mixed low-level waste (MLLW) currently stored in the US Department of Energy complex. The alternatives considered were innovative nonthermal treatments for organic liquids and sludges, process residue, soil and debris. Vacuum desorption or various washing approaches are considered for treatment of soil, residue and debris. Organic destruction methods include mediated electrochemical oxidation, catalytic wet oxidation, and acid digestion. Other methods studied included stabilization technologies and mercury separation of treatment residues. This study is a companion to the integrated thermal treatment study which examined 19 alternatives for thermal treatment of MLLW waste. The quantities and physical and chemical compositions of the input waste are based on the inventory database developed by the US Department of Energy. The Integrated Nonthermal Treatment Systems (INTS) systems were evaluated using the same waste input (2,927 pounds per hour) as the Integrated Thermal Treatment Systems (ITTS). 48 refs., 68 figs., 37 tabs.

Path integral for stochastic inflation: Nonperturbative volume weighting, complex histories, initial conditions, and the end of inflation

Science.gov (United States)

Gratton, Steven

2011-09-01

In this paper we present a path integral formulation of stochastic inflation. Volume weighting can be naturally implemented from this new perspective in a very straightforward way when compared to conventional Langevin approaches. With an in-depth study of inflation in a quartic potential, we investigate how the inflaton evolves and how inflation typically ends both with and without volume weighting. The calculation can be carried to times beyond those accessible to conventional Fokker-Planck approaches. Perhaps unexpectedly, complex histories sometimes emerge with volume weighting. The reward for this excursion into the complex plane is an insight into how volume-weighted inflation both loses memory of initial conditions and ends via slow roll. The slow-roll end of inflation mitigates certain “Youngness Paradox”-type criticisms of the volume-weighted paradigm. Thus it is perhaps time to rehabilitate proper-time volume weighting as a viable measure for answering at least some interesting cosmological questions.

Path integral for stochastic inflation: Nonperturbative volume weighting, complex histories, initial conditions, and the end of inflation

International Nuclear Information System (INIS)

Gratton, Steven

2011-01-01

In this paper we present a path integral formulation of stochastic inflation. Volume weighting can be naturally implemented from this new perspective in a very straightforward way when compared to conventional Langevin approaches. With an in-depth study of inflation in a quartic potential, we investigate how the inflaton evolves and how inflation typically ends both with and without volume weighting. The calculation can be carried to times beyond those accessible to conventional Fokker-Planck approaches. Perhaps unexpectedly, complex histories sometimes emerge with volume weighting. The reward for this excursion into the complex plane is an insight into how volume-weighted inflation both loses memory of initial conditions and ends via slow roll. The slow-roll end of inflation mitigates certain ''Youngness Paradox''-type criticisms of the volume-weighted paradigm. Thus it is perhaps time to rehabilitate proper-time volume weighting as a viable measure for answering at least some interesting cosmological questions.

K East basin sludge volume estimates for integrated water treatment system

International Nuclear Information System (INIS)

Pearce, K.L.

1998-01-01

This document provides estimates of the volume of sludge expected from Integrated Process Strategy (IPS) processing of the fuel elements and in the fuel storage canisters in K East Basin. The original estimates were based on visual observations of fuel element condition in the basin and laboratory measurements of canister sludge density. Revision 1 revised the volume estimates of sludge from processing of the fuel elements based on additional data from evaluations of material from the KE Basin fuel subsurface examinations. A nominal Working Estimate and an upper level Working Bound is developed for the canister sludge and the fuel wash sludge components in the KE Basin

Long-Term Prediction of Emergency Department Revenue and Visitor Volume Using Autoregressive Integrated Moving Average Model

Directory of Open Access Journals (Sweden)

Chieh-Fan Chen

2011-01-01

Full Text Available This study analyzed meteorological, clinical and economic factors in terms of their effects on monthly ED revenue and visitor volume. Monthly data from January 1, 2005 to September 30, 2009 were analyzed. Spearman correlation and cross-correlation analyses were performed to identify the correlation between each independent variable, ED revenue, and visitor volume. Autoregressive integrated moving average (ARIMA model was used to quantify the relationship between each independent variable, ED revenue, and visitor volume. The accuracies were evaluated by comparing model forecasts to actual values with mean absolute percentage of error. Sensitivity of prediction errors to model training time was also evaluated. The ARIMA models indicated that mean maximum temperature, relative humidity, rainfall, non-trauma, and trauma visits may correlate positively with ED revenue, but mean minimum temperature may correlate negatively with ED revenue. Moreover, mean minimum temperature and stock market index fluctuation may correlate positively with trauma visitor volume. Mean maximum temperature, relative humidity and stock market index fluctuation may correlate positively with non-trauma visitor volume. Mean maximum temperature and relative humidity may correlate positively with pediatric visitor volume, but mean minimum temperature may correlate negatively with pediatric visitor volume. The model also performed well in forecasting revenue and visitor volume.

Disposable photonic integrated circuits for evanescent wave sensors by ultra-high volume roll-to-roll method.

Science.gov (United States)

Aikio, Sanna; Hiltunen, Jussi; Hiitola-Keinänen, Johanna; Hiltunen, Marianne; Kontturi, Ville; Siitonen, Samuli; Puustinen, Jarkko; Karioja, Pentti

2016-02-08

Flexible photonic integrated circuit technology is an emerging field expanding the usage possibilities of photonics, particularly in sensor applications, by enabling the realization of conformable devices and introduction of new alternative production methods. Here, we demonstrate that disposable polymeric photonic integrated circuit devices can be produced in lengths of hundreds of meters by ultra-high volume roll-to-roll methods on a flexible carrier. Attenuation properties of hundreds of individual devices were measured confirming that waveguides with good and repeatable performance were fabricated. We also demonstrate the applicability of the devices for the evanescent wave sensing of ambient refractive index. The production of integrated photonic devices using ultra-high volume fabrication, in a similar manner as paper is produced, may inherently expand methods of manufacturing low-cost disposable photonic integrated circuits for a wide range of sensor applications.

Integrated thermal treatment system study: Phase 1 results. Volume 1

International Nuclear Information System (INIS)

Feizollahi, F.; Quapp, W.J.; Hempill, H.G.; Groffie, F.J.

1994-07-01

An integrated systems engineering approach is used for uniform comparison of widely varying thermal treatment technologies proposed for management of contact-handled mixed low-level waste (MLLW) currently stored in the US Department of Energy complex. Ten different systems encompassing several incineration design options are studied. All subsystems, including facilities, equipment, and methods needed for integration of each of the ten systems are identified. Typical subsystems needed for complete treatment of MLLW are incoming waste receiving and preparation (characterization, sorting, sizing, and separation), thermal treatment, air pollution control, primary and secondary stabilization, metal decontamination, metal melting, mercury recovery, lead recovery, and special waste and aqueous waste treatment. The evaluation is performed by developing a preconceptual design package and planning life-cycle cost (PLCC) estimates for each system. As part of the preconceptual design process, functional and operational requirements, flow sheets and mass balances, and conceptual equipment layouts are developed for each system. The PLCC components estimated are technology development, production facility construction, pre-operation, operation and maintenance, and decontamination and decommissioning. Preconceptual design data and other technology information gathered during the study are examined and areas requiring further development, testing, and evaluation are identified and recommended. Using a qualitative method, each of the ten systems are ranked

Human Factors, Habitability and Environmental Health and the Human Integration Design Handbook. Volume 2

Science.gov (United States)

Houbec, Keith; Tillman, Barry; Connolly, Janis

2010-01-01

For decades, Space Life Sciences and NASA as an Agency have considered NASA-STD-3000, Man-Systems Integration Standards, a significant contribution to human spaceflight programs and to human-systems integration in general. The document has been referenced in numerous design standards both within NASA and by organizations throughout the world. With research program and project results being realized, advances in technology and new information in a variety of topic areas now available, the time arrived to update this extensive suite of requirements and design information. During the past several years, a multi-NASA center effort has been underway to write the update to NASA-STD-3000 with standards and design guidance that would be applicable to all future human spaceflight programs. NASA-STD-3001 - Volumes 1 and 2 - and the Human Integration Design Handbook (HIDH) were created. Volume 1, Crew Health, establishes NASA s spaceflight crew health standards for the pre-flight, in-flight, and post-flight phases of human spaceflight. Volume 2, Human Factors, Habitability and Environmental Health, focuses on the requirements of human-system integration and how the human crew interacts with other systems, and how the human and the system function together to accomplish the tasks for mission success. The HIDH is a compendium of human spaceflight history and knowledge, and provides useful background information and research findings. And as the HIDH is a stand-alone companion to the Standards, the maintenance of the document has been streamlined. This unique and flexible approach ensures that the content is current and addresses the fundamental advances of human performance and human capabilities and constraints research. Current work focuses on the development of new sections of Volume 2 and collecting updates to the HIDH. The new sections in development expand the scope of the standard and address mission operations and support operations. This effort is again collaboration

Study of scattering cross section of a plasma column using Green's function volume integral equation method

Science.gov (United States)

Soltanmoradi, Elmira; Shokri, Babak

2017-05-01

In this article, the electromagnetic wave scattering from plasma columns with inhomogeneous electron density distribution is studied by the Green's function volume integral equation method. Due to the ready production of such plasmas in the laboratories and their practical application in various technological fields, this study tries to find the effects of plasma parameters such as the electron density, radius, and pressure on the scattering cross-section of a plasma column. Moreover, the incident wave frequency influence of the scattering pattern is demonstrated. Furthermore, the scattering cross-section of a plasma column with an inhomogeneous collision frequency profile is calculated and the effect of this inhomogeneity is discussed first in this article. These results are especially used to determine the appropriate conditions for radar cross-section reduction purposes. It is shown that the radar cross-section of a plasma column reduces more for a larger collision frequency, for a relatively lower plasma frequency, and also for a smaller radius. Furthermore, it is found that the effect of the electron density on the scattering cross-section is more obvious in comparison with the effect of other plasma parameters. Also, the plasma column with homogenous collision frequency can be used as a better shielding in contrast to its inhomogeneous counterpart.

Integrated optics nano-opto-fluidic sensor based on whispering gallery modes for picoliter volume refractometry

International Nuclear Information System (INIS)

Gilardi, Giovanni; Beccherelli, Romeo

2013-01-01

We propose and numerically investigate an integrated optics refractometric nano-opto-fluidic sensor based on whispering gallery modes in sapphire microspheres. A measurand fluid is injected in a micromachined reservoir defined in between the microsphere and an optical waveguide. The wavelength shift due to changes in the refractive index of the measurand fluid are studied for a set of different configurations by the finite element method and a high sensitivity versus fluid volume is found. The proposed device can be tailored to work with a minimum fluid volume of 1 pl and a sensitivity up of 2000 nm/(RIU·nl). We introduce a figure of merit which quantifies the amplifying effect on the sensitivity of high quality factor resonators and allows us to compare different devices. (paper)

Altered Gray Matter Volume and White Matter Integrity in College Students with Mobile Phone Dependence

OpenAIRE

Wang, Yongming; Zou, Zhiling; Song, Hongwen; Xu, Xiaodan; Wang, Huijun; d?Oleire Uquillas, Federico; Huang, Xiting

2016-01-01

Mobile phone dependence (MPD) is a behavioral addiction that has become an increasing public mental health issue. While previous research has explored some of the factors that may predict MPD, the underlying neural mechanisms of MPD have not been investigated yet. The current study aimed to explore the microstructural variations associated with MPD as measured with functional Magnetic Resonance Imaging (fMRI). Gray matter volume (GMV) and white matter (WM) integrity [four indices: fractional ...

Life sciences payload definition and integration study. Volume 3: Appendices

Science.gov (United States)

1972-01-01

Detail design information concerning payloads for biomedical research projects conducted during space missions is presented. Subjects discussed are: (1) equipment modules and equipment item lists, (2) weight and volume breakdown by payload and equipment units, (3) longitudinal floor arrangement configuration, and (4) nonbaseline second generation layouts.

A Calderón multiplicative preconditioner for coupled surface-volume electric field integral equations

KAUST Repository

Bagci, Hakan; Andriulli, Francesco P.; Cools, Kristof; Olyslager, Femke; Michielssen, Eric

2010-01-01

A well-conditioned coupled set of surface (S) and volume (V) electric field integral equations (S-EFIE and V-EFIE) for analyzing wave interactions with densely discretized composite structures is presented. Whereas the V-EFIE operator is well

Molar excess volumes of liquid hydrogen and neon mixtures from path integral simulation

International Nuclear Information System (INIS)

Challa, S.R.; Johnson, J.K.

1999-01-01

Volumetric properties of liquid mixtures of neon and hydrogen have been calculated using path integral hybrid Monte Carlo simulations. Realistic potentials have been used for the three interactions involved. Molar volumes and excess volumes of these mixtures have been evaluated for various compositions at 29 and 31.14 K, and 30 atm. Significant quantum effects are observed in molar volumes. Quantum simulations agree well with experimental molar volumes. Calculated excess volumes agree qualitatively with experimental values. However, contrary to the existing understanding that large positive deviations from ideal mixtures are caused due to quantum effects in Ne - H 2 mixtures, both classical as well as quantum simulations predict the large positive deviations from ideal mixtures. Further investigations using two other Ne - H 2 potentials of Lennard - Jones (LJ) type show that excess volumes are very sensitive to the cross-interaction potential. We conclude that the cross-interaction potential employed in our simulations is accurate for volumetric properties. This potential is more repulsive compared to the two LJ potentials tested, which have been obtained by two different combining rules. This repulsion and a comparatively lower potential well depth can explain the positive deviations from ideal mixing. copyright 1999 American Institute of Physics

AC/ARNG Integrated Division Concept Study, Appendices, Volume 3

National Research Council Canada - National Science Library

Twohig, John

1997-01-01

...) division headquarters. The US Army Training and Doctrine Command (TRADOC) was tasked to conduct a viability assessment of the AC/ARNG Integrated Division concept and focus on merits and implementation issues...

Visual-motor integration and fine motor skills at 6½ years of age and associations with neonatal brain volumes in children born extremely preterm in Sweden: a population-based cohort study.

Science.gov (United States)

Bolk, Jenny; Padilla, Nelly; Forsman, Lea; Broström, Lina; Hellgren, Kerstin; Åden, Ulrika

2018-02-17

This exploratory study aimed to investigate associations between neonatal brain volumes and visual-motor integration (VMI) and fine motor skills in children born extremely preterm (EPT) when they reached 6½ years of age. Prospective population-based cohort study in Stockholm, Sweden, during 3 years. All children born before gestational age, 27 weeks, during 2004-2007 in Stockholm, without major morbidities and impairments, and who underwent MRI at term-equivalent age. Brain volumes were calculated using morphometric analyses in regions known to be involved in VMI and fine motor functions. VMI was assessed with The Beery-Buktenica Developmental Test of Visual-Motor Integration-sixth edition and fine motor skills were assessed with the manual dexterity subtest from the Movement Assessment Battery for Children-second edition, at 6½ years. Associations between the brain volumes and VMI and fine motor skills were evaluated using partial correlation, adjusted for total cerebral parenchyma and sex. Out of 107 children born at gestational age skills (r=0.54, P=0.01). Associations were also seen between fine motor skills and the volume of the cerebellum (r=0.42, P=0.02), brainstem (r=0.47, P=0.008) and grey matter (r=-0.38, P=0.04). Neonatal brain volumes in areas known to be involved in VMI and fine motor skills were associated with scores for these two functions when children born EPT without major brain lesions or cerebral palsy were evaluated at 6½ years of age. Establishing clear associations between early brain volume alterations and later VMI and/or fine motor skills could make early interventions possible. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Prehospital tidal volume influences hospital tidal volume: A cohort study.

Science.gov (United States)

Stoltze, Andrew J; Wong, Terrence S; Harland, Karisa K; Ahmed, Azeemuddin; Fuller, Brian M; Mohr, Nicholas M

2015-06-01

The purposes of the study are to describe current practice of ventilation in a modern air medical system and to measure the association of ventilation strategy with subsequent ventilator care and acute respiratory distress syndrome (ARDS). Retrospective observational cohort study of intubated adult patients (n = 235) transported by a university-affiliated air medical transport service to a 711-bed tertiary academic center between July 2011 and May 2013. Low tidal volume ventilation was defined as tidal volumes less than or equal to 8 mL/kg predicted body weight. Multivariable regression was used to measure the association between prehospital tidal volume, hospital ventilation strategy, and ARDS. Most patients (57%) were ventilated solely with bag valve ventilation during transport. Mean tidal volume of mechanically ventilated patients was 8.6 mL/kg predicted body weight (SD, 0.2 mL/kg). Low tidal volume ventilation was used in 13% of patients. Patients receiving low tidal volume ventilation during air medical transport were more likely to receive low tidal volume ventilation in the emergency department (P tidal volume (P = .840). Low tidal volume ventilation was rare during air medical transport. Air transport ventilation strategy influenced subsequent ventilation but was not associated with ARDS. Copyright © 2015 Elsevier Inc. All rights reserved.

The Environment for Application Software Integration and Execution (EASIE), version 1.0. Volume 2: Program integration guide

Science.gov (United States)

Jones, Kennie H.; Randall, Donald P.; Stallcup, Scott S.; Rowell, Lawrence F.

1988-01-01

The Environment for Application Software Integration and Execution, EASIE, provides a methodology and a set of software utility programs to ease the task of coordinating engineering design and analysis codes. EASIE was designed to meet the needs of conceptual design engineers that face the task of integrating many stand-alone engineering analysis programs. Using EASIE, programs are integrated through a relational data base management system. In volume 2, the use of a SYSTEM LIBRARY PROCESSOR is used to construct a DATA DICTIONARY describing all relations defined in the data base, and a TEMPLATE LIBRARY. A TEMPLATE is a description of all subsets of relations (including conditional selection criteria and sorting specifications) to be accessed as input or output for a given application. Together, these form the SYSTEM LIBRARY which is used to automatically produce the data base schema, FORTRAN subroutines to retrieve/store data from/to the data base, and instructions to a generic REVIEWER program providing review/modification of data for a given template. Automation of these functions eliminates much of the tedious, error prone work required by the usual approach to data base integration.

New Internet search volume-based weighting method for integrating various environmental impacts

Energy Technology Data Exchange (ETDEWEB)

Ji, Changyoon, E-mail: changyoon@yonsei.ac.kr; Hong, Taehoon, E-mail: hong7@yonsei.ac.kr

2016-01-15

Weighting is one of the steps in life cycle impact assessment that integrates various characterized environmental impacts as a single index. Weighting factors should be based on the society's preferences. However, most previous studies consider only the opinion of some people. Thus, this research proposes a new weighting method that determines the weighting factors of environmental impact categories by considering public opinion on environmental impacts using the Internet search volumes for relevant terms. To validate the new weighting method, the weighting factors for six environmental impacts calculated by the new weighting method were compared with the existing weighting factors. The resulting Pearson's correlation coefficient between the new and existing weighting factors was from 0.8743 to 0.9889. It turned out that the new weighting method presents reasonable weighting factors. It also requires less time and lower cost compared to existing methods and likewise meets the main requirements of weighting methods such as simplicity, transparency, and reproducibility. The new weighting method is expected to be a good alternative for determining the weighting factor. - Highlight: • A new weighting method using Internet search volume is proposed in this research. • The new weighting method reflects the public opinion using Internet search volume. • The correlation coefficient between new and existing weighting factors is over 0.87. • The new weighting method can present the reasonable weighting factors. • The proposed method can be a good alternative for determining the weighting factors.

New Internet search volume-based weighting method for integrating various environmental impacts

International Nuclear Information System (INIS)

Ji, Changyoon; Hong, Taehoon

2016-01-01

Weighting is one of the steps in life cycle impact assessment that integrates various characterized environmental impacts as a single index. Weighting factors should be based on the society's preferences. However, most previous studies consider only the opinion of some people. Thus, this research proposes a new weighting method that determines the weighting factors of environmental impact categories by considering public opinion on environmental impacts using the Internet search volumes for relevant terms. To validate the new weighting method, the weighting factors for six environmental impacts calculated by the new weighting method were compared with the existing weighting factors. The resulting Pearson's correlation coefficient between the new and existing weighting factors was from 0.8743 to 0.9889. It turned out that the new weighting method presents reasonable weighting factors. It also requires less time and lower cost compared to existing methods and likewise meets the main requirements of weighting methods such as simplicity, transparency, and reproducibility. The new weighting method is expected to be a good alternative for determining the weighting factor. - Highlight: • A new weighting method using Internet search volume is proposed in this research. • The new weighting method reflects the public opinion using Internet search volume. • The correlation coefficient between new and existing weighting factors is over 0.87. • The new weighting method can present the reasonable weighting factors. • The proposed method can be a good alternative for determining the weighting factors.

Integrated hollow microneedle-optofluidic biosensor for therapeutic drug monitoring in sub-nanoliter volumes

Science.gov (United States)

Ranamukhaarachchi, Sahan A.; Padeste, Celestino; Dübner, Matthias; Häfeli, Urs O.; Stoeber, Boris; Cadarso, Victor J.

2016-07-01

Therapeutic drug monitoring (TDM) typically requires painful blood drawn from patients. We propose a painless and minimally-invasive alternative for TDM using hollow microneedles suitable to extract extremely small volumes (microneedle is functionalized to be used as a micro-reactor during sample collection to trap and bind target drug candidates during extraction, without requirements of sample transfer. An optofluidic device is integrated with this microneedle to rapidly quantify drug analytes with high sensitivity using a straightforward absorbance scheme. Vancomycin is currently detected by using volumes ranging between 50-100 μL with a limit of detection (LoD) of 1.35 μM. The proposed microneedle-optofluidic biosensor can detect vancomycin with a sample volume of 0.6 nL and a LoD of <100 nM, validating this painless point of care system with significant potential to reduce healthcare costs and patients suffering.

Process automation system for integration and operation of Large Volume Plasma Device

International Nuclear Information System (INIS)

Sugandhi, R.; Srivastava, P.K.; Sanyasi, A.K.; Srivastav, Prabhakar; Awasthi, L.M.; Mattoo, S.K.

2016-01-01

Highlights: • Analysis and design of process automation system for Large Volume Plasma Device (LVPD). • Data flow modeling for process model development. • Modbus based data communication and interfacing. • Interface software development for subsystem control in LabVIEW. - Abstract: Large Volume Plasma Device (LVPD) has been successfully contributing towards understanding of the plasma turbulence driven by Electron Temperature Gradient (ETG), considered as a major contributor for the plasma loss in the fusion devices. Large size of the device imposes certain difficulties in the operation, such as access of the diagnostics, manual control of subsystems and large number of signals monitoring etc. To achieve integrated operation of the machine, automation is essential for the enhanced performance and operational efficiency. Recently, the machine is undergoing major upgradation for the new physics experiments. The new operation and control system consists of following: (1) PXIe based fast data acquisition system for the equipped diagnostics; (2) Modbus based Process Automation System (PAS) for the subsystem controls and (3) Data Utilization System (DUS) for efficient storage, processing and retrieval of the acquired data. In the ongoing development, data flow model of the machine’s operation has been developed. As a proof of concept, following two subsystems have been successfully integrated: (1) Filament Power Supply (FPS) for the heating of W- filaments based plasma source and (2) Probe Positioning System (PPS) for control of 12 number of linear probe drives for a travel length of 100 cm. The process model of the vacuum production system has been prepared and validated against acquired pressure data. In the next upgrade, all the subsystems of the machine will be integrated in a systematic manner. The automation backbone is based on 4-wire multi-drop serial interface (RS485) using Modbus communication protocol. Software is developed on LabVIEW platform using

Process automation system for integration and operation of Large Volume Plasma Device

Energy Technology Data Exchange (ETDEWEB)

Sugandhi, R., E-mail: ritesh@ipr.res.in; Srivastava, P.K.; Sanyasi, A.K.; Srivastav, Prabhakar; Awasthi, L.M.; Mattoo, S.K.

2016-11-15

Highlights: • Analysis and design of process automation system for Large Volume Plasma Device (LVPD). • Data flow modeling for process model development. • Modbus based data communication and interfacing. • Interface software development for subsystem control in LabVIEW. - Abstract: Large Volume Plasma Device (LVPD) has been successfully contributing towards understanding of the plasma turbulence driven by Electron Temperature Gradient (ETG), considered as a major contributor for the plasma loss in the fusion devices. Large size of the device imposes certain difficulties in the operation, such as access of the diagnostics, manual control of subsystems and large number of signals monitoring etc. To achieve integrated operation of the machine, automation is essential for the enhanced performance and operational efficiency. Recently, the machine is undergoing major upgradation for the new physics experiments. The new operation and control system consists of following: (1) PXIe based fast data acquisition system for the equipped diagnostics; (2) Modbus based Process Automation System (PAS) for the subsystem controls and (3) Data Utilization System (DUS) for efficient storage, processing and retrieval of the acquired data. In the ongoing development, data flow model of the machine’s operation has been developed. As a proof of concept, following two subsystems have been successfully integrated: (1) Filament Power Supply (FPS) for the heating of W- filaments based plasma source and (2) Probe Positioning System (PPS) for control of 12 number of linear probe drives for a travel length of 100 cm. The process model of the vacuum production system has been prepared and validated against acquired pressure data. In the next upgrade, all the subsystems of the machine will be integrated in a systematic manner. The automation backbone is based on 4-wire multi-drop serial interface (RS485) using Modbus communication protocol. Software is developed on LabVIEW platform using

A study of nasal cavity volume in patients with cleft lip and palate by magnetic resonance imaging

International Nuclear Information System (INIS)

Nakano, Kenichi

1996-01-01

Nasal cavity volume was studied in 11 patients with cleft lip and palate by magnetic resonance imaging. The areas of horizontal sections of the nasal cavity on the cleft and non-cleft sides were measured with the help of a personal computer and image analyzing software. Nasal cavity volume was determined by integrated volume calculation. The volume of each side was measured before and after cleft lip repair. Before cleft lip repair nasal cavity volume on the non-cleft side was larger than on the cleft side. However there was no significant difference in the volume of the cleft and non-cleft sides after cleft lip repair. (author)

A study of nasal cavity volume in patients with cleft lip and palate by magnetic resonance imaging

Energy Technology Data Exchange (ETDEWEB)

Nakano, Kenichi [Showa Univ., Tokyo (Japan). School of Medicine

1996-02-01

Nasal cavity volume was studied in 11 patients with cleft lip and palate by magnetic resonance imaging. The areas of horizontal sections of the nasal cavity on the cleft and non-cleft sides were measured with the help of a personal computer and image analyzing software. Nasal cavity volume was determined by integrated volume calculation. The volume of each side was measured before and after cleft lip repair. Before cleft lip repair nasal cavity volume on the non-cleft side was larger than on the cleft side. However there was no significant difference in the volume of the cleft and non-cleft sides after cleft lip repair. (author)

Analysis of Buried Dielectric Objects Using Higher-Order MoM for Volume Integral Equations

DEFF Research Database (Denmark)

Kim, Oleksiy S.; Meincke, Peter; Breinbjerg, Olav

2004-01-01

A higher-order method of moments (MoM) is applied to solve a volume integral equation for dielectric objects in layered media. In comparison to low-order methods, the higher-order MoM, which is based on higher-order hierarchical Legendre vector basis functions and curvilinear hexahedral elements,...

Derivations of the solid angle subtended at a point by first- and second-order surfaces and volumes as a function of elliptic integrals

International Nuclear Information System (INIS)

Cramer, S.N.

1999-01-01

An analytical study of the solid angle subtended at a point by objects of first and second algebraic order has been made. It is shown that the derived solid angle for all such objects is in the form of a general elliptic integral, which can be written as a linear combination of elliptic integrals of the first and third kind and elementary functions. Many common surfaces and volumes have been investigated, including the conic sections and their volumes of revolution. The principal feature of the study is the manipulation of solid-angle equations into integral forms that can be matched with those found in handbook tables. These integrals are amenable to computer special function library routine analysis requiring no direct interaction with elliptic integrals by the user. The general case requires the solution of a fourth-order equation before specific solid-angle formulations can be made, but for many common geometric objects this equation can be solved by elementary means. Methods for the testing and application of solid-angle equations with Monte Carlo rejection and estimation techniques are presented. Approximate and degenerate forms of the equations are shown, and methods for the evaluation of the solid angle of a torus are outlined

Cerebral volumes, neuronal integrity and brain inflammation measured by MRI in patients receiving PI monotherapy or triple therapy.

Science.gov (United States)

Valero, Ignacio Pérez; Baeza, Alicia Gonzalez; Hernandez-Tamames, Juan Antonio; Monge, Susana; Arnalich, Francisco; Arribas, Jose Ramon

2014-01-01

Penetration of protease inhibitors (PI) in the central nervous system (CNS) is limited. Therefore, there are concerns about the capacity of PI monotherapy (MT) to control HIV in CNS and preserve brain integrity. Exploratory case-control study designed to compare neuronal integrity and brain inflammation in HIV-suppressed patients (>2 years) with and without neurocognitive impairment (NI), treated with MT or triple therapy (TT), 3-Tesla cerebral magnetic resonance image (MRI) and spectroscopy (MRS) were used to evaluate neuronal integrity (volume of cerebral structures and MRS levels of N-acetyl-aspartate (NAA)) and brain inflammation (MRS levels of myo-inositol (MI) and choline (CHO)). MRS biomarkers were measured in 4 voxels located in basal ganglia, frontal (2) and parietal lobes. A comprehensive battery of tests (14 tests - 7 domains) was used to diagnose neurocognitive impairment (1). We included 18 neurocognitively impaired patients (MT: 10, TT: 8) and 21 without NI (MT: 9; TT: 12, Table 1). Subset of patients with NI: cerebral volumes and MRS biomarkers were mostly similar between MT and TT with exception of the right cingulate nucleolus volume (MT: 8854±1851 vs TT: 10482±1107 mm(3); p<0.04), CHO levels in basal ganglia (MT: 0.44±0.05 vs TT: 0.37±0.03 MMOL/L; p<0.01) and the NAA levels in parietal lobe (MT: 1.49±0.12 vs 1.70±0.13 MMOL/L; p<0.01). Subset of patients without NI: cerebral volumes and MRS biomarkers were mostly similar between MT and TT with exception of MI levels in frontal lobe (MT: 1.20±0.36 vs 0.81±0.25 MMOL/L; p=0.01). We did not find significant differences in cerebral volumes or MRS biomarkers in most areas of the brain. However, we found higher levels of inflammation and neuronal damage in some brain areas of patients who received MT. This observation has to be taken into caution while we could not adjust our results by potential confounders. Further investigation is needed to confirm these preliminary results.

Solution of volume-surface integral equations using higher-order hierarchical Legendre basis functions

DEFF Research Database (Denmark)

Kim, Oleksiy S.; Meincke, Peter; Breinbjerg, Olav

2007-01-01

The problem of electromagnetic scattering by composite metallic and dielectric objects is solved using the coupled volume-surface integral equation (VSIE). The method of moments (MoM) based on higher-order hierarchical Legendre basis functions and higher-order curvilinear geometrical elements...... with the analytical Mie series solution. Scattering by more complex metal-dielectric objects are also considered to compare the presented technique with other numerical methods....

Expressing intrinsic volumes as rotational integrals

DEFF Research Database (Denmark)

Auneau, Jeremy Michel; Jensen, Eva Bjørn Vedel

2010-01-01

A new rotational formula of Crofton type is derived for intrinsic volumes of a compact subset of positive reach. The formula provides a functional defined on the section of X with a j-dimensional linear subspace with rotational average equal to the intrinsic volumes of X. Simplified forms of the ...

Transient analysis of electromagnetic wave interactions on high-contrast scatterers using volume electric field integral equation

KAUST Repository

Sayed, Sadeed Bin; Ulku, Huseyin Arda; Bagci, Hakan

2014-01-01

A marching on-in-time (MOT)-based time domain volume electric field integral equation (TD-VEFIE) solver is proposed for accurate and stable analysis of electromagnetic wave interactions on high-contrast scatterers. The stability is achieved using

Control volume based hydrocephalus research; a phantom study

Science.gov (United States)

Cohen, Benjamin; Voorhees, Abram; Madsen, Joseph; Wei, Timothy

2009-11-01

Hydrocephalus is a complex spectrum of neurophysiological disorders involving perturbation of the intracranial contents; primarily increased intraventricular cerebrospinal fluid (CSF) volume and intracranial pressure are observed. CSF dynamics are highly coupled to the cerebral blood flows and pressures as well as the mechanical properties of the brain. Hydrocephalus, as such, is a very complex biological problem. We propose integral control volume analysis as a method of tracking these important interactions using mass and momentum conservation principles. As a first step in applying this methodology in humans, an in vitro phantom is used as a simplified model of the intracranial space. The phantom's design consists of a rigid container filled with a compressible gel. Within the gel a hollow spherical cavity represents the ventricular system and a cylindrical passage represents the spinal canal. A computer controlled piston pump supplies sinusoidal volume fluctuations into and out of the flow phantom. MRI is used to measure fluid velocity and volume change as functions of time. Independent pressure measurements and momentum flow rate measurements are used to calibrate the MRI data. These data are used as a framework for future work with live patients and normal individuals. Flow and pressure measurements on the flow phantom will be presented through the control volume framework.

AC/ARNG Integrated Division Concept Study, Main Report, Volume 1

National Research Council Canada - National Science Library

Twohig, John

1997-01-01

...) division headquarters. The US Army Training and Doctrine Command (TRADOC) was tasked to conduct a viability assessment of the AC/ARNG Integrated Division concept and focus on merits and implementation issues...

Adequacy of power-to-volume scaling philosophy to simulate natural circulation in Integral Test Facilities

International Nuclear Information System (INIS)

Nayak, A.K.; Vijayan, P.K.; Saha, D.; Venkat Raj, V.; Aritomi, Masanori

1998-01-01

Theoretical and experimental investigations were carried out to study the adequacy of power-to-volume scaling philosophy for the simulation of natural circulation and to establish the scaling philosophy applicable for the design of the Integral Test Facility (ITF-AHWR) for the Indian Advanced Heavy Water Reactor (AHWR). The results indicate that a reduction in the flow channel diameter of the scaled facility as required by the power-to-volume scaling philosophy may affect the simulation of natural circulation behaviour of the prototype plants. This is caused by the distortions due to the inability to simulate the frictional resistance of the scaled facility. Hence, it is recommended that the flow channel diameter of the scaled facility should be as close as possible to the prototype. This was verified by comparing the natural circulation behaviour of a prototype 220 MWe Indian PHWR and its scaled facility (FISBE-1) designed based on power-to-volume scaling philosophy. It is suggested from examinations using a mathematical model and a computer code that the FISBE-1 simulates the steady state and the general trend of transient natural circulation behaviour of the prototype reactor adequately. Finally the proposed scaling method was applied for the design of the ITF-AHWR. (author)

Evaluation of deep gray matter volume, cortical thickness and white matter integrity in patients with typical absence epilepsy: a study using voxelwise-based techniques

Energy Technology Data Exchange (ETDEWEB)

Correa, D.G.; Ventura, N.; Tukamoto, G.; Gasparetto, E.L. [Federal University of Rio de Janeiro, Department of Radiology, Hospital Universitario Clementino Fraga Filho, Rio de Janeiro, RJ (Brazil); Clinica de Diagnostico por Imagem (CDPI), Rio de Janeiro (Brazil); Zimmermann, N. [Federal University of Rio de Janeiro, Department of Radiology, Hospital Universitario Clementino Fraga Filho, Rio de Janeiro, RJ (Brazil); Pontifical Catholic University of Rio Grande do Sul, Department of Psychology, Porto Alegre (Brazil); Doring, T.M. [Clinica de Diagnostico por Imagem (CDPI), Rio de Janeiro (Brazil); Leme, J.; Pereira, M. [Federal University of Rio de Janeiro, Department of Radiology, Hospital Universitario Clementino Fraga Filho, Rio de Janeiro, RJ (Brazil); Andrea, I. d' ; Rego, C.; Alves-Leon, S.V. [Federal University of Rio de Janeiro, Department of Neurology, Epilepsy Center, Hospital Universitario Clementino Fraga Filho, Rio de Janeiro (Brazil)

2017-03-15

The objective of this study was to evaluate the cortical thickness and the volume of deep gray matter structures, measured from 3D T1-weighted gradient echo imaging, and white matter integrity, by diffusion tensor imaging (DTI) in patients with typical absence epilepsy (AE). Patients (n = 19) with typical childhood AE and juvenile AE, currently taking antiepileptic medication, were compared with control subjects (n = 19), matched for gender and age. 3D T1 magnetization-prepared rapid gradient echo-weighted imaging and DTI along 30 noncolinear directions were performed using a 1.5-T MR scanner. FreeSurfer was used to perform cortical volumetric reconstruction and segmentation of deep gray matter structures. For tract-based spatial statistics analysis of DTI, a white matter skeleton was created, along with a permutation-based inference with 5000 permutations. A threshold of p < 0.05 was used to identify abnormalities in fractional anisotropy (FA). The mean, radial, and axial diffusivities were also projected onto the mean FA skeleton. Patients with AE presented decreased FA and increased mean diffusivity and radial diffusivity values in the genu and the body of the corpus callosum and right anterior corona radiata, as well as decreased axial diffusivity in the left posterior thalamic radiation, inferior cerebellar peduncle, right cerebral peduncle, and right corticospinal tract. However, there were no significant differences in cortical thickness or deep gray matter structure volumes between patients with AE and controls. Abnormalities found in white matter integrity may help to better understand the pathophysiology of AE and optimize diagnosis and treatment strategies. (orig.)

Evaluation of deep gray matter volume, cortical thickness and white matter integrity in patients with typical absence epilepsy: a study using voxelwise-based techniques

International Nuclear Information System (INIS)

Correa, D.G.; Ventura, N.; Tukamoto, G.; Gasparetto, E.L.; Zimmermann, N.; Doring, T.M.; Leme, J.; Pereira, M.; Andrea, I. d'; Rego, C.; Alves-Leon, S.V.

2017-01-01

The objective of this study was to evaluate the cortical thickness and the volume of deep gray matter structures, measured from 3D T1-weighted gradient echo imaging, and white matter integrity, by diffusion tensor imaging (DTI) in patients with typical absence epilepsy (AE). Patients (n = 19) with typical childhood AE and juvenile AE, currently taking antiepileptic medication, were compared with control subjects (n = 19), matched for gender and age. 3D T1 magnetization-prepared rapid gradient echo-weighted imaging and DTI along 30 noncolinear directions were performed using a 1.5-T MR scanner. FreeSurfer was used to perform cortical volumetric reconstruction and segmentation of deep gray matter structures. For tract-based spatial statistics analysis of DTI, a white matter skeleton was created, along with a permutation-based inference with 5000 permutations. A threshold of p < 0.05 was used to identify abnormalities in fractional anisotropy (FA). The mean, radial, and axial diffusivities were also projected onto the mean FA skeleton. Patients with AE presented decreased FA and increased mean diffusivity and radial diffusivity values in the genu and the body of the corpus callosum and right anterior corona radiata, as well as decreased axial diffusivity in the left posterior thalamic radiation, inferior cerebellar peduncle, right cerebral peduncle, and right corticospinal tract. However, there were no significant differences in cortical thickness or deep gray matter structure volumes between patients with AE and controls. Abnormalities found in white matter integrity may help to better understand the pathophysiology of AE and optimize diagnosis and treatment strategies. (orig.)

MRI markers for mild cognitive impairment: comparisons between white matter integrity and gray matter volume measurements.

Directory of Open Access Journals (Sweden)

Yu Zhang

Full Text Available The aim of the study was to evaluate the value of assessing white matter integrity using diffusion tensor imaging (DTI for classification of mild cognitive impairment (MCI and prediction of cognitive impairments in comparison to brain atrophy measurements using structural MRI. Fifty-one patients with MCI and 66 cognitive normal controls (CN underwent DTI and T1-weighted structural MRI. DTI measures included fractional anisotropy (FA and radial diffusivity (DR from 20 predetermined regions-of-interest (ROIs in the commissural, limbic and association tracts, which are thought to be involved in Alzheimer's disease; measures of regional gray matter (GM volume included 21 ROIs in medial temporal lobe, parietal cortex, and subcortical regions. Significant group differences between MCI and CN were detected by each MRI modality: In particular, reduced FA was found in splenium, left isthmus cingulum and fornix; increased DR was found in splenium, left isthmus cingulum and bilateral uncinate fasciculi; reduced GM volume was found in bilateral hippocampi, left entorhinal cortex, right amygdala and bilateral thalamus; and thinner cortex was found in the left entorhinal cortex. Group classifications based on FA or DR was significant and better than classifications based on GM volume. Using either DR or FA together with GM volume improved classification accuracy. Furthermore, all three measures, FA, DR and GM volume were similarly accurate in predicting cognitive performance in MCI patients. Taken together, the results imply that DTI measures are as accurate as measures of GM volume in detecting brain alterations that are associated with cognitive impairment. Furthermore, a combination of DTI and structural MRI measurements improves classification accuracy.

Integrating model of the Project Independence Evaluation System. Volume VI. Data documentation. Part I

Energy Technology Data Exchange (ETDEWEB)

Allen, B J

1979-02-01

This documentation describes the PIES Integrating Model as it existed on January 1, 1978. This volume contains two chapters. In Chapter I, Overview, the following subjects are briefly described: supply data, EIA projection series and scenarios, demand data and assumptions, and supply assumptions - oil and gas availabilities. Chapter II contains supply and demand data tables and sources used by the PIES Integrating Model for the mid-range scenario target years 1985 and 1990. Tabulated information is presented for demand, price, and elasticity data; coal data; imports data; oil and gas data; refineries data; synthetics, shale, and solar/geothermal data; transportation data; and utilities data.

Case-study application of venture analysis: the integrated energy utility. Volume 3. Appendices

Energy Technology Data Exchange (ETDEWEB)

Fein, E; Gordon, T J; King, R; Kropp, F G; Shuchman, H L; Stover, J; Hausz, W; Meyer, C

1978-11-01

The appendices for a case-study application of venture analysis for an integrated energy utility for commercialization are presented. The following are included and discussed: utility interviews; net social benefits - quantitative calculations; the financial analysis model; market penetration decision model; international district heating systems; political and regulatory environment; institutional impacts.

Investigation Of The Effects Of Reflow Profile Parameters On Lead-free Solder Bump Volumes And Joint Integrity

Science.gov (United States)

Amalu, E. H.; Lui, Y. T.; Ekere, N. N.; Bhatti, R. S.; Takyi, G.

2011-01-01

The electronics manufacturing industry was quick to adopt and use the Surface Mount Technology (SMT) assembly technique on realization of its huge potentials in achieving smaller, lighter and low cost product implementations. Increasing global customer demand for miniaturized electronic products is a key driver in the design, development and wide application of high-density area array package format. Electronic components and their associated solder joints have reduced in size as the miniaturization trend in packaging continues to be challenged by printing through very small stencil apertures required for fine pitch flip-chip applications. At very narrow aperture sizes, solder paste rheology becomes crucial for consistent paste withdrawal. The deposition of consistent volume of solder from pad-to-pad is fundamental to minimizing surface mount assembly defects. This study investigates the relationship between volume of solder paste deposit (VSPD) and the volume of solder bump formed (VSBF) after reflow, and the effect of reflow profile parameters on lead-free solder bump formation and the associated solder joint integrity. The study uses a fractional factorial design (FFD) of 24-1 Ramp-Soak-Spike reflow profile, with all main effects and two-way interactions estimable to determine the optimal factorial combination. The results from the study show that the percentage change in the VSPD depends on the combination of the process parameters and reliability issues could become critical as the size of solder joints soldered on the same board assembly vary greatly. Mathematical models describe the relationships among VSPD, VSBF and theoretical volume of solder paste. Some factors have main effects across the volumes and a number of interactions exist among them. These results would be useful for R&D personnel in designing and implementing newer applications with finer-pitch interconnect.

Mixed waste focus area integrated technical baseline report. Phase I, Volume 2: Revision 0

International Nuclear Information System (INIS)

1996-01-01

This document (Volume 2) contains the Appendices A through J for the Mixed Waste Focus Area Integrated Technical Baseline Report Phase I for the Idaho National Engineering Laboratory. Included are: Waste Type Managers' Resumes, detailed information on wastewater, combustible organics, debris, unique waste, and inorganic homogeneous solids and soils, and waste data information. A detailed list of technology deficiencies and site needs identification is also provided

Integrated remote sensing and visualization (IRSV) system for transportation infrastructure operations and management, phase one, volume 3 : use of scanning LiDAR in structural evaluation of bridges.

Science.gov (United States)

2009-12-01

This volume introduces several applications of remote bridge inspection technologies studied in : this Integrated Remote Sensing and Visualization (IRSV) study using ground-based LiDAR : systems. In particular, the application of terrestrial LiDAR fo...

Reduced caudate volume and enhanced striatal-DMN integration in chess experts.

Science.gov (United States)

Duan, Xujun; He, Sheng; Liao, Wei; Liang, Dongmei; Qiu, Lihua; Wei, Luqing; Li, Yuan; Liu, Chengyi; Gong, Qiyong; Chen, Huafu

2012-04-02

The superior capability of chess experts largely depends on quick automatic processing skills which are considered to be mediated by the caudate nucleus. We asked whether continued practice or rehearsal of the skill over a long period of time can lead to structural changes in this region. We found that, comparing to novice controls, grandmaster and master level Chinese chess players (GM/Ms), who had a mean period of over 10years of tournament and training practice, exhibited significant smaller gray-matter volume in the bilateral caudate nuclei. When these regions were used as seeds in functional connectivity analysis in resting-state fMRI, significantly enhanced integration was found in GM/Ms between the caudate and the default mode network (DMN), a constellation of brain areas important for goal-directed cognitive performance and theory of mind. These findings demonstrate the structural changes in the caudate nucleus in response to its extensive engagement in chess problem solving, and its enhanced functional integration with widely distributed circuitry to better support high-level cognitive control of behavior. Copyright © 2012 Elsevier Inc. All rights reserved.

A hybrid finite-volume and finite difference scheme for depth-integrated non-hydrostatic model

Science.gov (United States)

Yin, Jing; Sun, Jia-wen; Wang, Xing-gang; Yu, Yong-hai; Sun, Zhao-chen

2017-06-01

A depth-integrated, non-hydrostatic model with hybrid finite difference and finite volume numerical algorithm is proposed in this paper. By utilizing a fraction step method, the governing equations are decomposed into hydrostatic and non-hydrostatic parts. The first part is solved by using the finite volume conservative discretization method, whilst the latter is considered by solving discretized Poisson-type equations with the finite difference method. The second-order accuracy, both in time and space, of the finite volume scheme is achieved by using an explicit predictor-correction step and linear construction of variable state in cells. The fluxes across the cell faces are computed in a Godunov-based manner by using MUSTA scheme. Slope and flux limiting technique is used to equip the algorithm with total variation dimensioning property for shock capturing purpose. Wave breaking is treated as a shock by switching off the non-hydrostatic pressure in the steep wave front locally. The model deals with moving wet/dry front in a simple way. Numerical experiments are conducted to verify the proposed model.

A Calderón multiplicative preconditioner for coupled surface-volume electric field integral equations

KAUST Repository

Bagci, Hakan

2010-08-01

A well-conditioned coupled set of surface (S) and volume (V) electric field integral equations (S-EFIE and V-EFIE) for analyzing wave interactions with densely discretized composite structures is presented. Whereas the V-EFIE operator is well-posed even when applied to densely discretized volumes, a classically formulated S-EFIE operator is ill-posed when applied to densely discretized surfaces. This renders the discretized coupled S-EFIE and V-EFIE system ill-conditioned, and its iterative solution inefficient or even impossible. The proposed scheme regularizes the coupled set of S-EFIE and V-EFIE using a Calderón multiplicative preconditioner (CMP)-based technique. The resulting scheme enables the efficient analysis of electromagnetic interactions with composite structures containing fine/subwavelength geometric features. Numerical examples demonstrate the efficiency of the proposed scheme. © 2006 IEEE.

Integration of wind generation forecasts. Volume 2

International Nuclear Information System (INIS)

Ahlstrom, M.; Zavadil, B.; Jones, L.

2005-01-01

WindLogics is a company that specializes in atmospheric modelling, visualization and fine-scale forecasting systems for the wind power industry. A background of the organization was presented. The complexities of wind modelling were discussed. Issues concerning location and terrain, shear, diurnal and interannual variability were reviewed. It was suggested that wind power producers should aim to be mainstream, and that variability should be considered as intrinsic to fuel supply. Various utility operating impacts were outlined. Details of an Xcel NSP wind integration study were presented, as well as a studies conducted in New York state and Colorado. It was concluded that regulations and load following impacts with wind energy integration are modest. Overall impacts are dominated by costs incurred to accommodate wind generation variability and uncertainty in the day-ahead time frame. Cost impacts can be reduced with adjustments to operating strategies, improvements in wind forecasting and access to real-time markets. Details of WindLogic's wind energy forecast system were presented, as well as examples of day ahead and hour ahead forecasts and wind speed and power forecasts. Screenshots of control room integration, EMS integration and simulations were presented. Details of a utility-scale wind energy forecasting system funded by Xcel Renewable Development Fund (RDF) were also presented. The goal of the system was to optimize the way that wind forecast information is integrated into the control room environment. Project components were outlined. It was concluded that accurate day-ahead forecasting can lead to significant asset optimization. It was recommended that wind plants share data, and aim to resolve issues concerning grid codes and instrumentation. refs., tabs., figs

Transient analysis of scattering from ferromagnetic objects using Landau-Lifshitz-Gilbert and volume integral equations

KAUST Repository

Sayed, Sadeed Bin

2016-11-02

An explicit marching on-in-time scheme for analyzing transient electromagnetic wave interactions on ferromagnetic scatterers is described. The proposed method solves a coupled system of time domain magnetic field volume integral and Landau-Lifshitz-Gilbert (LLG) equations. The unknown fluxes and fields are discretized using full and half Schaubert-Wilton-Glisson functions in space and bandlimited temporal interpolation functions in time. The coupled system is cast in the form of an ordinary differential equation and integrated in time using a PE(CE)m type linear multistep method to obtain the unknown expansion coefficients. Numerical results demonstrating the stability and accuracy of the proposed scheme are presented.

Transient analysis of scattering from ferromagnetic objects using Landau-Lifshitz-Gilbert and volume integral equations

KAUST Repository

Sayed, Sadeed Bin; Ulku, Huseyin Arda; Bagci, Hakan

2016-01-01

An explicit marching on-in-time scheme for analyzing transient electromagnetic wave interactions on ferromagnetic scatterers is described. The proposed method solves a coupled system of time domain magnetic field volume integral and Landau-Lifshitz-Gilbert (LLG) equations. The unknown fluxes and fields are discretized using full and half Schaubert-Wilton-Glisson functions in space and bandlimited temporal interpolation functions in time. The coupled system is cast in the form of an ordinary differential equation and integrated in time using a PE(CE)m type linear multistep method to obtain the unknown expansion coefficients. Numerical results demonstrating the stability and accuracy of the proposed scheme are presented.

Corticospinal tract integrity and lesion volume play different roles in chronic hemiparesis and its improvement through motor practice.

Science.gov (United States)

Sterr, Annette; Dean, Phil J A; Szameitat, Andre J; Conforto, Adriana Bastos; Shen, Shan

2014-05-01

Initial evidence suggests that the integrity of the ipsilesional corticospinal tract (CST) after stroke is strongly related to motor function in the chronic state but not the treatment gain induced by motor rehabilitation. We examined the association of motor status and treatment benefit by testing patients with a wide range of severity of hemiparesis of the left and right upper extremity. Diffusion tensor imaging was performed in 22 patients beyond 12 months after onset of stroke with severe to moderate hemiparesis. Motor function was tested before and after 2 weeks of modified constraint-induced movement therapy. CST integrity, but not lesion volume, correlated with the motor ability measures of the Wolf Motor Function Test and the Motor Activity Log. No differences were found between left and right hemiparesis. Motor performance improved significantly with the treatment regime, and did so equally for patients with left and right arm paresis. However, treatment benefit was not associated with either CST integrity or lesion volume. CST integrity correlated best in this small trial with chronic long-term status but not treatment-induced improvements. The CST may play a different role in the mechanisms mediating long-term outcome compared to those underlying practice-induced gains after a chronic plateau in motor function.

Process modeling for the Integrated Thermal Treatment System (ITTS) study

Energy Technology Data Exchange (ETDEWEB)

Liebelt, K.H.; Brown, B.W.; Quapp, W.J.

1995-09-01

This report describes the process modeling done in support of the integrated thermal treatment system (ITTS) study, Phases 1 and 2. ITTS consists of an integrated systems engineering approach for uniform comparison of widely varying thermal treatment technologies proposed for treatment of the contact-handled mixed low-level wastes (MLLW) currently stored in the U.S. Department of Energy complex. In the overall study, 19 systems were evaluated. Preconceptual designs were developed that included all of the various subsystems necessary for a complete installation, from waste receiving through to primary and secondary stabilization and disposal of the processed wastes. Each system included the necessary auxiliary treatment subsystems so that all of the waste categories in the complex were fully processed. The objective of the modeling task was to perform mass and energy balances of the major material components in each system. Modeling of trace materials, such as pollutants and radioactive isotopes, were beyond the present scope. The modeling of the main and secondary thermal treatment, air pollution control, and metal melting subsystems was done using the ASPEN PLUS process simulation code, Version 9.1-3. These results were combined with calculations for the remainder of the subsystems to achieve the final results, which included offgas volumes, and mass and volume waste reduction ratios.

Process modeling for the Integrated Thermal Treatment System (ITTS) study

International Nuclear Information System (INIS)

Liebelt, K.H.; Brown, B.W.; Quapp, W.J.

1995-09-01

This report describes the process modeling done in support of the integrated thermal treatment system (ITTS) study, Phases 1 and 2. ITTS consists of an integrated systems engineering approach for uniform comparison of widely varying thermal treatment technologies proposed for treatment of the contact-handled mixed low-level wastes (MLLW) currently stored in the U.S. Department of Energy complex. In the overall study, 19 systems were evaluated. Preconceptual designs were developed that included all of the various subsystems necessary for a complete installation, from waste receiving through to primary and secondary stabilization and disposal of the processed wastes. Each system included the necessary auxiliary treatment subsystems so that all of the waste categories in the complex were fully processed. The objective of the modeling task was to perform mass and energy balances of the major material components in each system. Modeling of trace materials, such as pollutants and radioactive isotopes, were beyond the present scope. The modeling of the main and secondary thermal treatment, air pollution control, and metal melting subsystems was done using the ASPEN PLUS process simulation code, Version 9.1-3. These results were combined with calculations for the remainder of the subsystems to achieve the final results, which included offgas volumes, and mass and volume waste reduction ratios

Research Studies Index. Authors and Subjects. Volume 1 through Volume 43 (1929-1975).

Science.gov (United States)

Drazan, Joseph, Comp.; Scott, Paula, Comp.

This volume contains author and subject indexes for volumes 1 through 43 (1929-1975) of "Research Studies," a scholarly, multi-disciplinary quarterly published at Washington State University. Each author index entry includes the title, volume, and inclusive pagination of the article. The subject index is a keyword-out-of-context…

A short introduction to cytogenetic studies in mammals with reference to the present volume.

Science.gov (United States)

Graphodatsky, A; Ferguson-Smith, M A; Stanyon, R

2012-01-01

Genome diversity has long been studied from the comparative cytogenetic perspective. Early workers documented differences between species in diploid chromosome number and fundamental number. Banding methods allowed more detailed descriptions of between-species rearrangements and classes of differentially staining chromosome material. The infusion of molecular methods into cytogenetics provided a third revolution, which is still not exhausted. Chromosome painting has provided a global view of the translocation history of mammalian genome evolution, well summarized in the contributions to this special volume. More recently, FISH of cloned DNA has provided details on defining breakpoint and intrachromosomal marker order, which have helped to document inversions and centromere repositioning. The most recent trend in comparative molecular cytogenetics is to integrate sequencing information in order to formulate and test reconstructions of ancestral genomes and phylogenomic hypotheses derived from comparative cytogenetics. The integration of comparative cytogenetics and sequencing promises to provide an understanding of what drives chromosome rearrangements and genome evolution in general. We believe that the contributions in this volume, in no small way, point the way to the next phase in cytogenetic studies. Copyright © 2012 S. Karger AG, Basel.

Residents' perceptions of an integrated longitudinal curriculum: a qualitative study.

Science.gov (United States)

Lubitz, Rebecca; Lee, Joseph; Hillier, Loretta M

2015-01-01

The purpose of this study was to explore family medicine residents' perceptions of a newly restructured integrated longitudinal curriculum. A purposeful sample of 16 family medicine residents participated in focus group interviews conducted from a grounded theory perspective to identify the characteristics of this training model that contribute to and that challenge learning. Eight key themes were identified: continuity of care, relevance to family medicine, autonomy, program-focused preparation, professional development as facilitated by role modeling, patient volume, clarity of expectations for learners, and logistics. Positive learning experiences were marked by high levels of autonomy, continuity, and relevance to family medicine. Less favorable learning experiences were characterized by limited opportunities for continuity of care, limited relevance to family medicine practice and unclear expectations for the resident's role. Family physician-led learning experiences contributed to residents' understanding of the full scope of family medicine practice, more so than specialist-led experiences. The logistics of implementing the integrated block were challenging and negatively impacted continuity and learning. This study suggests that an integrated longitudinalized family medicine block training model has the potential to support the principles of a longitudinal integrated competency-based curriculum to effectively prepare residents for family medicine practice.

An efficient explicit marching on in time solver for magnetic field volume integral equation

KAUST Repository

Sayed, Sadeed Bin

2015-07-25

An efficient explicit marching on in time (MOT) scheme for solving the magnetic field volume integral equation is proposed. The MOT system is cast in the form of an ordinary differential equation and is integrated in time using a PE(CE)m multistep scheme. At each time step, a system with a Gram matrix is solved for the predicted/corrected field expansion coefficients. Depending on the type of spatial testing scheme Gram matrix is sparse or consists of blocks with only diagonal entries regardless of the time step size. Consequently, the resulting MOT scheme is more efficient than its implicit counterparts, which call for inversion of fuller matrix system at lower frequencies. Numerical results, which demonstrate the efficiency, accuracy, and stability of the proposed MOT scheme, are presented.

Economic development through biomass system integration: Volume 1

Energy Technology Data Exchange (ETDEWEB)

DeLong, M.M. [Northern States Power Co., Minneapolis, MN (United States)

1995-10-01

This report documents a feasibility study for an integrated biomass power system, where an energy crop (alfalfa) is the feedstock for a processing plant and a power plant (integrated gasification combined cycle) in a way that benefits the facility owners. Chapters describe alfalfa basics, production risks, production economics, transportation and storage, processing, products, market analysis, business analysis, environmental impact, and policy issues. 69 figs., 63 tabs.

Bare-Hand Volume Cracker for Raw Volume Data Analysis

Directory of Open Access Journals (Sweden)

Bireswar Laha

2016-09-01

Full Text Available Analysis of raw volume data generated from different scanning technologies faces a variety of challenges, related to search, pattern recognition, spatial understanding, quantitative estimation, and shape description. In a previous study, we found that the Volume Cracker (VC 3D interaction (3DI technique mitigated some of these problems, but this result was from a tethered glove-based system with users analyzing simulated data. Here, we redesigned the VC by using untethered bare-hand interaction with real volume datasets, with a broader aim of adoption of this technique in research labs. We developed symmetric and asymmetric interfaces for the Bare-Hand Volume Cracker (BHVC through design iterations with a biomechanics scientist. We evaluated our asymmetric BHVC technique against standard 2D and widely used 3D interaction techniques with experts analyzing scanned beetle datasets. We found that our BHVC design significantly outperformed the other two techniques. This study contributes a practical 3DI design for scientists, documents lessons learned while redesigning for bare-hand trackers, and provides evidence suggesting that 3D interaction could improve volume data analysis for a variety of visual analysis tasks. Our contribution is in the realm of 3D user interfaces tightly integrated with visualization, for improving the effectiveness of visual analysis of volume datasets. Based on our experience, we also provide some insights into hardware-agnostic principles for design of effective interaction techniques.

Visual–motor integration and fine motor skills at 6½ years of age and associations with neonatal brain volumes in children born extremely preterm in Sweden: a population-based cohort study

Science.gov (United States)

Padilla, Nelly; Forsman, Lea; Broström, Lina; Hellgren, Kerstin; Åden, Ulrika

2018-01-01

Objectives This exploratory study aimed to investigate associations between neonatal brain volumes and visual–motor integration (VMI) and fine motor skills in children born extremely preterm (EPT) when they reached 6½ years of age. Setting Prospective population-based cohort study in Stockholm, Sweden, during 3 years. Participants All children born before gestational age, 27 weeks, during 2004–2007 in Stockholm, without major morbidities and impairments, and who underwent MRI at term-equivalent age. Main outcome measures Brain volumes were calculated using morphometric analyses in regions known to be involved in VMI and fine motor functions. VMI was assessed with The Beery-Buktenica Developmental Test of Visual–Motor Integration—sixth edition and fine motor skills were assessed with the manual dexterity subtest from the Movement Assessment Battery for Children—second edition, at 6½ years. Associations between the brain volumes and VMI and fine motor skills were evaluated using partial correlation, adjusted for total cerebral parenchyma and sex. Results Out of 107 children born at gestational age motor skills (r=0.54, P=0.01). Associations were also seen between fine motor skills and the volume of the cerebellum (r=0.42, P=0.02), brainstem (r=0.47, P=0.008) and grey matter (r=−0.38, P=0.04). Conclusions Neonatal brain volumes in areas known to be involved in VMI and fine motor skills were associated with scores for these two functions when children born EPT without major brain lesions or cerebral palsy were evaluated at 6½ years of age. Establishing clear associations between early brain volume alterations and later VMI and/or fine motor skills could make early interventions possible. PMID:29455171

Ocean Thermal Energy Converstion (OTEC) test facilities study program. Final report. Volume II. Part B

Energy Technology Data Exchange (ETDEWEB)

None

1977-01-17

Results are presented of an 8-month study to develop alternative non-site-specific OTEC facilities/platform requirements for an integrated OTEC test program which may include land and floating test facilities. Volume II--Appendixes is bound in three parts (A, B, and C) which together comprise a compendium of the most significant detailed data developed during the study. Part B provides an annotated test list and describes component tests and system tests.

The influence of a balanced volume replacement concept on inflammation, endothelial activation, and kidney integrity in elderly cardiac surgery patients.

Science.gov (United States)

Boldt, Joachim; Suttner, Stephan; Brosch, Christian; Lehmann, Andreas; Röhm, Kerstin; Mengistu, Andinet

2009-03-01

A balanced fluid replacement strategy appears to be promising for correcting hypovolemia. The benefits of a balanced fluid replacement regimen were studied in elderly cardiac surgery patients. In a randomized clinical trial, 50 patients aged >75 years undergoing cardiac surgery received a balanced 6% HES 130/0.42 plus a balanced crystalloid solution (n = 25) or a non-balanced HES in saline plus saline solution (n = 25) to keep pulmonary capillary wedge pressure/central venous pressure between 12-14 mmHg. Acid-base status, inflammation, endothelial activation (soluble intercellular adhesion molecule-1, kidney integrity (kidney-specific proteins glutathione transferase-alpha; neutrophil gelatinase-associated lipocalin) were studied after induction of anesthesia, 5 h after surgery, 1 and 2 days thereafter. Serum creatinine (sCr) was measured approximately 60 days after discharge. A total of 2,750 +/- 640 mL of balanced and 2,820 +/- 550 mL of unbalanced HES were given until the second POD. Base excess (BE) was significantly reduced in the unbalanced (from +1.21 +/- 0.3 to -4.39 +/- 1.0 mmol L(-1) 5 h after surgery; P volume replacement strategy including a balanced HES and a balanced crystalloid solution resulted in moderate beneficial effects on acid-base status, inflammation, endothelial activation, and kidney integrity compared to a conventional unbalanced volume replacement regimen.

Irradiation of the chest wall and regional nodes as an integrated volume with IMRT for breast cancer after mastectomy: from dosimetry to clinical side-effects

International Nuclear Information System (INIS)

Ma Jinli; Li Jiongxiong; Zhu Chuanying

2012-01-01

Objective: To discuss dosimetric characteristics of an intensity-modulated radiotherapy (IMRT) technique for treating the chest wall and regional nodes as an integrated volume after modified radical mastectomy (MRM), and observe acute side-effects following irradiation. Methods: From June 2009 to August 2010, 75 patients were randomly enrolled. Of these, 41 had left-sided breast cancer. Each eligible patient had a planning CT in treatment position, on which the chest wall, supraclavicular,and infraclavicular nodes, +/-internal mammary region, were contoured as an integrated volume. A multi-beam IMRT plan was designed with the target either as a whole or two segments divided at below the clavicle head. A dose of 50 Gy in 25 fractions was prescribed to cover at least 90% of the PTV. Internal mammary region was included in 31 cases. Dose volume histograms were used to evaluate the IMRT plans. The acute side effects were followed up regularly during and after irradiation. The independent two-sample t-test was used to compare the dosimetric parameters between integrated and segmented plans. Results: Planning design was completed for all patients, including 55 integrated and 20 segmented plans, with median number of beams of 8. The conformity index and homogeneity index was 1.43 ± 0.15 and 0.14 ± 0.02, respectively. Patients with internal mammary region included in PTV had higher homogeneity index PT. The percent volume of PTV receiving > 110% prescription dose was max , D mean V 107% , and V 110% , between integrated and segmented plans (t=2.19 -2.53, P=0.013-0.031). ≥ grade 2 radiation dermatitis was identified in 3 2 patients (grade 2 in 22 patients, grade 3 in 10 patients), mostly occurred within 1 - 2 weeks after treatment. The sites of moist desquamation were anterior axillary fold (27/37) and chest wall (10/37). Only 2 patients developed grade 2 radiation pneumonitis. Conclusions: The IMRT technique applied after MRM with integrated locoregional target volume

Life sciences payload definition and integration study, task C and D. Volume 1: Management summary

Science.gov (United States)

1973-01-01

The findings of a study to define the required payloads for conducting life science experiments in space are presented. The primary objectives of the study are: (1) identify research functions to be performed aboard life sciences spacecraft laboratories and necessary equipment, (2) develop conceptual designs of potential payloads, (3) integrate selected laboratory designs with space shuttle configurations, and (4) establish cost analysis of preliminary program planning.

Mars power system concept definition study. Volume 2: Appendices

Science.gov (United States)

Littman, Franklin D.

1994-01-01

This report documents the work performed by Rockwell International's Rocketdyne Division on NASA Contract No. NAS3-25808 (Task Order No. 16) entitled 'Mars Power System Definition Study'. This work was performed for NASA's Lewis Research Center (LeRC). The report is divided into two volumes as follows: Volume 1 - Study Results; and Volume 2 - Appendices. The results of the power system characterization studies, operations studies, and technology evaluations are summarized in Volume 1. The appendices include complete, standalone technology development plans for each candidate power system that was investigated.

FY 1996 solid waste integrated life-cycle forecast characteristics summary. Volumes 1 and 2

Energy Technology Data Exchange (ETDEWEB)

Templeton, K.J.

1996-05-23

For the past six years, a waste volume forecast has been collected annually from onsite and offsite generators that currently ship or are planning to ship solid waste to the Westinghouse Hanford Company`s Central Waste Complex (CWC). This document provides a description of the physical waste forms, hazardous waste constituents, and radionuclides of the waste expected to be shipped to the CWC from 1996 through the remaining life cycle of the Hanford Site (assumed to extend to 2070). In previous years, forecast data has been reported for a 30-year time period; however, the life-cycle approach was adopted this year to maintain consistency with FY 1996 Multi-Year Program Plans. This document is a companion report to two previous reports: the more detailed report on waste volumes, WHC-EP-0900, FY1996 Solid Waste Integrated Life-Cycle Forecast Volume Summary and the report on expected containers, WHC-EP-0903, FY1996 Solid Waste Integrated Life-Cycle Forecast Container Summary. All three documents are based on data gathered during the FY 1995 data call and verified as of January, 1996. These documents are intended to be used in conjunction with other solid waste planning documents as references for short and long-term planning of the WHC Solid Waste Disposal Division`s treatment, storage, and disposal activities over the next several decades. This document focuses on two main characteristics: the physical waste forms and hazardous waste constituents of low-level mixed waste (LLMW) and transuranic waste (both non-mixed and mixed) (TRU(M)). The major generators for each waste category and waste characteristic are also discussed. The characteristics of low-level waste (LLW) are described in Appendix A. In addition, information on radionuclides present in the waste is provided in Appendix B. The FY 1996 forecast data indicate that about 100,900 cubic meters of LLMW and TRU(M) waste is expected to be received at the CWC over the remaining life cycle of the site. Based on

FY 1996 solid waste integrated life-cycle forecast characteristics summary. Volumes 1 and 2

International Nuclear Information System (INIS)

Templeton, K.J.

1996-01-01

For the past six years, a waste volume forecast has been collected annually from onsite and offsite generators that currently ship or are planning to ship solid waste to the Westinghouse Hanford Company's Central Waste Complex (CWC). This document provides a description of the physical waste forms, hazardous waste constituents, and radionuclides of the waste expected to be shipped to the CWC from 1996 through the remaining life cycle of the Hanford Site (assumed to extend to 2070). In previous years, forecast data has been reported for a 30-year time period; however, the life-cycle approach was adopted this year to maintain consistency with FY 1996 Multi-Year Program Plans. This document is a companion report to two previous reports: the more detailed report on waste volumes, WHC-EP-0900, FY1996 Solid Waste Integrated Life-Cycle Forecast Volume Summary and the report on expected containers, WHC-EP-0903, FY1996 Solid Waste Integrated Life-Cycle Forecast Container Summary. All three documents are based on data gathered during the FY 1995 data call and verified as of January, 1996. These documents are intended to be used in conjunction with other solid waste planning documents as references for short and long-term planning of the WHC Solid Waste Disposal Division's treatment, storage, and disposal activities over the next several decades. This document focuses on two main characteristics: the physical waste forms and hazardous waste constituents of low-level mixed waste (LLMW) and transuranic waste (both non-mixed and mixed) (TRU(M)). The major generators for each waste category and waste characteristic are also discussed. The characteristics of low-level waste (LLW) are described in Appendix A. In addition, information on radionuclides present in the waste is provided in Appendix B. The FY 1996 forecast data indicate that about 100,900 cubic meters of LLMW and TRU(M) waste is expected to be received at the CWC over the remaining life cycle of the site. Based on

Multidimensional singular integrals and integral equations

CERN Document Server

Mikhlin, Solomon Grigorievich; Stark, M; Ulam, S

1965-01-01

Multidimensional Singular Integrals and Integral Equations presents the results of the theory of multidimensional singular integrals and of equations containing such integrals. Emphasis is on singular integrals taken over Euclidean space or in the closed manifold of Liapounov and equations containing such integrals. This volume is comprised of eight chapters and begins with an overview of some theorems on linear equations in Banach spaces, followed by a discussion on the simplest properties of multidimensional singular integrals. Subsequent chapters deal with compounding of singular integrals

Quantifying normal ankle joint volume: An anatomic study

Directory of Open Access Journals (Sweden)

Draeger Reid

2009-01-01

Full Text Available Background: Many therapeutic and diagnostic modalities such as intraarticular injections, arthrography and ankle arthroscopy require introduction of fluid into the ankle joint. Little data are currently available in the literature regarding the maximal volume of normal, nonpathologic, human ankle joints. The purpose of this study was to measure the volume of normal human ankle joints. Materials and Methods: A fluoroscopic guided needle was passed into nine cadaveric adult ankle joints. The needle was connected to an intracompartmental pressure measurement device. A radiopaque dye was introduced into the joint in 2 mL boluses, while pressure measurements were recorded. Fluid was injected into the joint until three consecutive pressure measurements were similar, signifying a maximal joint volume. Results: The mean maximum ankle joint volume was 20.9 ± 4.9 mL (range, 16-30 mL. The mean ankle joint pressure at maximum volume was 142.2 ± 13.8 mm Hg (range, 122-166 mm Hg. Two of the nine samples showed evidence of fluid tracking into the synovial sheath of the flexor hallucis longus tendon. Conclusion: Maximal normal ankle joint volume was found to vary between 16-30 mL. This study ascertains the communication between the ankle joint and the flexor hallucis longus tendon sheath. Exceeding maximal ankle joint volume suggested by this study during therapeutic injections, arthrography, or arthroscopy could potentially damage the joint.

A study of nasal cavity volume by magnetic resonance imaging

Energy Technology Data Exchange (ETDEWEB)

Tosa, Yasuyoshi [Showa Univ., Tokyo (Japan). School of Medicine

1992-04-01

The nasal cavity volume in 69 healthy volunteers from 8 to 23 years old (17 males and 52 females) was studied using magnetic resonance imaging (MRI). Merits of MRI such as no radiation exposure, less artifact due to bone and air and measurement of intravascular blood flow; and demerits such as contraindication in users of heart pace-makers or magnetic clips, contraindication in people with claustrophobia and influence of environmental magnetic fields must be considered. A Magunetom M10 (Siemens), a superconduction device with 1.0 Tesla magnetic flux density was used. Enhanced patterns of T[sub 1], and pulse lines were photographed at 600 msec TR (repetition time) and 19 msec TE (echo time) using SE (spin echo) and short SE (spin echo), and 3 or 4 mm slices. Photographs were made of the piriform aperture, choana, superior-middle-inferior concha including the nasal meatus, the frontal sinus, maxillary sinus, cribriform plate, and upper surface of the palate. The line connecting the maximum depression point in the nasal root and the pontomedullary junction was selected by sagittal median section, because this corresponds well with the CM (canthomeatal) line which is useful in CT (computed tomography). The transverse section of the nasal cavity volume was traced by display console with an accessory MRI device and calculated by integration of the slice width. The increase of height and body weight neared a plateau at almost 16 years, whereas increase of nasal cavity volume continued until about 20 years. Pearson's coefficient of correlation and regression line were significant. There were no significant differences in these parameters between male and female groups. Comparatively strong correlation between nasal cavity volume, and age, height and body weight was statistically evident. (author).

Parallel, explicit, and PWTD-enhanced time domain volume integral equation solver

KAUST Repository

Liu, Yang

2013-07-01

Time domain volume integral equations (TDVIEs) are useful for analyzing transient scattering from inhomogeneous dielectric objects in applications as varied as photonics, optoelectronics, and bioelectromagnetics. TDVIEs typically are solved by implicit marching-on-in-time (MOT) schemes [N. T. Gres et al., Radio Sci., 36, 379-386, 2001], requiring the solution of a system of equations at each and every time step. To reduce the computational cost associated with such schemes, [A. Al-Jarro et al., IEEE Trans. Antennas Propagat., 60, 5203-5215, 2012] introduced an explicit MOT-TDVIE method that uses a predictor-corrector technique to stably update field values throughout the scatterer. By leveraging memory-efficient nodal spatial discretization and scalable parallelization schemes [A. Al-Jarro et al., in 28th Int. Rev. Progress Appl. Computat. Electromagn., 2012], this solver has been successfully applied to the analysis of scattering phenomena involving 0.5 million spatial unknowns. © 2013 IEEE.

Attention in spina bifida myelomeningocele: Relations with brain volume and integrity

Directory of Open Access Journals (Sweden)

Paulina A. Kulesz

2015-01-01

Full Text Available This study investigated the relations of tectal volume and superior parietal cortex, as well as alterations in tectocortical white matter connectivity, with the orienting and executive control attention networks in individuals with spina bifida myelomeningocele (SBM. Probabilistic diffusion tractography and quantification of tectal and superior parietal cortical volume were performed on 74 individuals aged 8–29 with SBM and a history of hydrocephalus. Behavioral assessments measured posterior (covert orienting and anterior (conflict resolution, attentional control attention network functions. Reduced tectal volume was associated with slower covert orienting; reduced superior parietal cortical volume was associated with slower conflict resolution; and increased axial diffusivity and radial diffusivity along both frontal and parietal tectocortical pathways were associated with reduced attentional control. Results suggest that components of both the orienting and executive control attention networks are impaired in SBM. Neuroanatomical disruption to the orienting network appears more robust and a direct consequence of characteristic midbrain dysmorphology; whereas, executive control difficulties may emerge from parietal cortical anomalies and reduced frontal and parietal cortical–subcortical white matter pathways susceptible to the pathophysiological effects of congenital hydrocephalus.

Method of moments solution of volume integral equations using higher-order hierarchical Legendre basis functions

DEFF Research Database (Denmark)

Kim, Oleksiy S.; Jørgensen, Erik; Meincke, Peter

2004-01-01

An efficient higher-order method of moments (MoM) solution of volume integral equations is presented. The higher-order MoM solution is based on higher-order hierarchical Legendre basis functions and higher-order geometry modeling. An unstructured mesh composed of 8-node trilinear and/or curved 27...... of magnitude in comparison to existing higher-order hierarchical basis functions. Consequently, an iterative solver can be applied even for high expansion orders. Numerical results demonstrate excellent agreement with the analytical Mie series solution for a dielectric sphere as well as with results obtained...

Proceedings of the twenty-fourth water reactor safety information meeting. Volume 2: Reactor pressure vessel embrittlement and thermal annealing; Reactor vessel lower head integrity; Evaluation and projection of steam generator tube condition and integrity

Energy Technology Data Exchange (ETDEWEB)

Monteleone, S. [comp.] [Brookhaven National Lab., Upton, NY (United States)

1997-02-01

This three-volume report contains papers presented at the Twenty-Fourth Water Reactor Safety Information Meeting held at the Bethesda Marriott Hotel, Bethesda, Maryland, October 21--23, 1996. The papers are printed in the order of their presentation in each session and describe progress and results of programs in nuclear safety research conducted in this country and abroad. Foreign participation in the meeting included papers presented by researchers from Czech Republic, Finland, France, Japan, Norway, Russia and United Kingdom. This volume is divided into the following sections: reactor pressure vessel embrittlement and thermal annealing; reactor vessel lower head integrity; and evaluation and projection of steam generator tube condition and integrity. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

Proceedings of the twenty-fourth water reactor safety information meeting. Volume 2: Reactor pressure vessel embrittlement and thermal annealing; Reactor vessel lower head integrity; Evaluation and projection of steam generator tube condition and integrity

International Nuclear Information System (INIS)

Monteleone, S.

1997-02-01

This three-volume report contains papers presented at the Twenty-Fourth Water Reactor Safety Information Meeting held at the Bethesda Marriott Hotel, Bethesda, Maryland, October 21--23, 1996. The papers are printed in the order of their presentation in each session and describe progress and results of programs in nuclear safety research conducted in this country and abroad. Foreign participation in the meeting included papers presented by researchers from Czech Republic, Finland, France, Japan, Norway, Russia and United Kingdom. This volume is divided into the following sections: reactor pressure vessel embrittlement and thermal annealing; reactor vessel lower head integrity; and evaluation and projection of steam generator tube condition and integrity. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database

Life sciences payload definition and integration study. Volume 2: Requirements, design, and planning studies for the carry-on laboratories. [for Spacelab

Science.gov (United States)

1974-01-01

The task phase concerned with the requirements, design, and planning studies for the carry-on laboratory (COL) began with a definition of biomedical research areas and candidate research equipment, and then went on to develop conceptual layouts for COL which were each evaluated in order to arrive at a final conceptual design. Each step in this design/evaluation process concerned itself with man/systems integration research and hardware, and life support and protective systems research and equipment selection. COL integration studies were also conducted and include attention to electrical power and data management requirements, operational considerations, and shuttle/Spacelab interface specifications. A COL program schedule was compiled, and a cost analysis was finalized which takes into account work breakdown, annual funding, and cost reduction guidelines.

Effective orbital volume and eyeball position: an MRI study.

Science.gov (United States)

Detorakis, Efstathios T; Drakonaki, Eleni; Papadaki, Efrosini; Pallikaris, Ioannis G; Tsilimbaris, Miltiadis K

2010-10-01

Previous studies have examined factors affecting the position of the eyeball to the orbit. This study examined the role of effective orbital volume (EOV), defined as the difference between orbital and eyeball volume, as a determinant of eyeball position, using MRI scans. Forty-six patients were recruited from the Department of Ophthalmology of the University Hospital of Heraklion, Crete Greece. Patients with a history of orbital disease were excluded. Distances between eyeball poles and orbital landmarks were measured in T1 weighted transverse, sagittal and coronal orbital images. The protrusion of the eyeball in the sagittal and transverse planes was recorded. The volume of the eyeball and bony orbit, the EOV, the volume of the extraocular muscles as well as clinical information (age, gender, Hertel exophthalmometry) were also recorded. EOV was significantly associated with orbital volume but not with eyeball volume. EOV was also significantly associated with transverse and sagittal globe protrusions. Females displayed significantly lower orbital and eyeball volumes as well as EOV than males but higher transverse globe protrusion than males. Variations in EOV are associated with orbital volume rather than with eyeball volume. EOV is associated with globe protrusion and may be taken into account in the planning of various procedures, including orbital decompression, treatment of enophthalmos or the size of orbital implants following enucleation.

Radwaste volume reduction and solidification by General Electric

International Nuclear Information System (INIS)

Green, T.A.; Weech, M.E.; Miller, G.P.; Eberle, J.W.

1982-01-01

Since 1978 General Electric has been actively engaged in developing a volume reduction and solidifcation system or treatment of radwaste generated in commercial nuclear power plants. The studies have been aimed at defining an integrated system that would be directly responsive to the rapid evolving needs of the industry for the volume reduction and solidification of low-level radwaste. The resulting General Electric Volume Reduction System (GEVRS) is an integrated system based on two processes: the first uses azeotropic distillation technology and is called AZTECH, and the second is controlled-air incineration...called INCA. The AZTECH process serves to remove water from concentrated salt solutions, ion exchange resins and filter sludge slurries and then encapsulates the dried solids into a dense plastic product. The INCA unit serves to reduce combustible wastes to ashes suitable for encapsulation into the same plastic product produced by AZTECH

Integrated remote sensing and visualization (IRSV) system for transportation infrastructure operations and management, phase one, volume 2 : knowledge modeling and database development.

Science.gov (United States)

2009-12-01

The Integrated Remote Sensing and Visualization System (IRSV) is being designed to accommodate the needs of todays Bridge Engineers at the : state and local level from several aspects that were documented in Volume One, Summary Report. The followi...

Volume 1: Survey of Available Information in Support of the Energy-Water Bandwidth Study of Desalination Systems

Energy Technology Data Exchange (ETDEWEB)

Rao, Prakash [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Aghajanzadeh, Arian [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sheaffer, Paul [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Morrow, William R. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Brueske, Sabine [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Dollinger, Caroline [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Price, Kevin [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sarker, Prateeti [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Ward, Nicholas [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Cresko, Joe [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

2016-10-01

The U.S. Department of Energy (DOE) has set a goal to reduce the cost of seawater desalination systems to $0.50/ cubic meter (m³) through the development of technology pathways to reduce energy, capital, operating, soft, and system integration costs.1 In support of this goal and to evaluate the technology pathways to lower the energy and carbon intensity of desalination while also reducing the total water cost, DOE is undertaking a comprehensive study of the energy consumption and carbon dioxide (CO₂) emissions for desalination technologies and systems. This study is being undertaken in two phases. Phase 1, Survey of Available Information in Support of the Energy-Water Bandwidth Study of Desalination Systems, collected the background information that will underpin Phase 2, the Energy Water Bandwidth Study for Desalination Systems. This report (Volume 1) summarizes the results from Phase 1. The results from Phase 2 will be summarized in Volume 2: Energy Water Bandwidth Study for Desalination Systems (Volume 2). The analysis effort for Phase 2 will utilize similar methods as other industry-specific Energy Bandwidth Studies developed by DOE,2 which has provided a framework to evaluate and compare energy savings potentials within and across manufacturing sectors at the macroscale. Volume 2 will assess the current state of desalination energy intensity and reduction potential through the use of advanced and emerging technologies. For the purpose of both phases of study, energy intensity is defined as the amount of energy required per unit of product water output (for example, kilowatt-hours per cubic meter of water produced). These studies will expand the scope of previous sectorial bandwidth studies by also evaluating CO₂ intensity and reduction opportunities and informing a techno-economic analysis of desalination systems. Volume 2 is expected to be completed in 2017.

Explicit solution of the time domain volume integral equation using a stable predictor-corrector scheme

KAUST Repository

Al Jarro, Ahmed

2012-11-01

An explicit marching-on-in-time (MOT) scheme for solving the time domain volume integral equation is presented. The proposed method achieves its stability by employing, at each time step, a corrector scheme, which updates/corrects fields computed by the explicit predictor scheme. The proposedmethod is computationally more efficient when compared to the existing filtering techniques used for the stabilization of explicit MOT schemes. Numerical results presented in this paper demonstrate that the proposed method maintains its stability even when applied to the analysis of electromagnetic wave interactions with electrically large structures meshed using approximately half a million discretization elements.

Explicit solution of the time domain volume integral equation using a stable predictor-corrector scheme

KAUST Repository

Al Jarro, Ahmed; Salem, Mohamed; Bagci, Hakan; Benson, Trevor; Sewell, Phillip D.; Vuković, Ana

2012-01-01

An explicit marching-on-in-time (MOT) scheme for solving the time domain volume integral equation is presented. The proposed method achieves its stability by employing, at each time step, a corrector scheme, which updates/corrects fields computed by the explicit predictor scheme. The proposedmethod is computationally more efficient when compared to the existing filtering techniques used for the stabilization of explicit MOT schemes. Numerical results presented in this paper demonstrate that the proposed method maintains its stability even when applied to the analysis of electromagnetic wave interactions with electrically large structures meshed using approximately half a million discretization elements.

6Li real potential volume integrals in elastic scattering and distorted-waveBorn approximation analyses

International Nuclear Information System (INIS)

Lezoch, P.; Trost, H.; Strohbusch, U.

1981-01-01

The magnitudes of volume integrals per interacting nucleon pair J/sub R/' calculated from a compilation of 6 Li potentials vary between 100 and 500 MeV fm 3 . They are grouped in discrete branches with J/sub R/(A) smoothly increasing with decreasing target mass. Comparison with the results for lighter projectiles restricts the ''physically meaningful'' branches to those characterized by J/sub R/ (A> or =48) 3 . ( 6 Li,d) reaction analyses yield the same fit qualities for 6 Li potentials of the different discrete families, but deduced spectroscopic factors jump (by factors of approx.3) when changing between successive families

Rigid 3D-3D registration of TOF MRA integrating vessel segmentation for quantification of recurrence volumes after coiling cerebral aneurysm

International Nuclear Information System (INIS)

Saering, Dennis; Forkert, Nils Daniel; Fiehler, Jens; Ries, Thorsten

2012-01-01

A fast and reproducible quantification of the recurrence volume of coiled aneurysms is required to enable a more timely evaluation of new coils. This paper presents two registration schemes for the semi-automatic quantification of aneurysm recurrence volumes based on baseline and follow-up 3D MRA TOF datasets. The quantification of shape changes requires a previous definition of corresponding structures in both datasets. For this, two different rigid registration methods have been developed and evaluated. Besides a state-of-the-art rigid registration method, a second approach integrating vessel segmentations is presented. After registration, the aneurysm recurrence volume can be calculated based on the difference image. The computed volumes were compared to manually extracted volumes. An evaluation based on 20 TOF MRA datasets (baseline and follow-up) of ten patients showed that both registration schemes are generally capable of providing sufficient registration results. Regarding the quantification of aneurysm recurrence volumes, the results suggest that the second segmentation-based registration method yields better results, while a reduction of the computation and interaction time is achieved at the same time. The proposed registration scheme incorporating vessel segmentation enables an improved quantification of recurrence volumes of coiled aneurysms with reduced computation and interaction time. (orig.)

The study of the volume and 1H MRS of the hippocampus in posttraumatic stress disorder

International Nuclear Information System (INIS)

Yang Bo; Zhou Yicheng; Xia Jun; Xia Liming; Wang Chengyuan

2006-01-01

Objective: To study the changes of the hippocampus metabolites and the hippoeampus volume with MRI, and to explore the posibble pathophysiology of the hippocampus injure in posttraumatic stress disorder(PTSD). Methods: Seventeen cases of PTSD and 17 age-matched normal subjects (control subjects) were examined on a clinical 1.5 T MRI/MRS system. Proton multi-voxel spectroscopy imaging ( 1 H-MRSI) was obtained from two sides of the hippocampus region. The metabolites included N-acetylaspartate (NAA), creatine and phosphocreatine (Cr), and choline-containing compounds (Cho). The values of NAA, Cr, and Cho were calculated by integration of their peaks. The volume of the hippocampus of the two sides and the brain volume were measured with volume analysis software, and the resulting data were normalized according to the individual brain volume. Both the value of the metabolites and volume of the hippocampus were compared between the two groups respectively. Results: The volumes of left and right hippocampus were (2130±221 )mm 3 and (2571±190) mm 3 in PTSD cases, and they were (2382±157) mm 3 and (2572±186) mm 3 in the control subjects. The volume of left hippocampus of PTSD was smaller than that of the control subjects (P 0.05). NAA and Cr was significantly reduced in PTSD (Left: NAA= 2.8±0.7, Cr=2.3±0.6; Right: NAA 2.9±0.9, Cr=2.3±0.7) bilaterally when compared with those of control subjects (Left: NAA=3.8±0.8, Cr=2.7±0.5; Right: NAA=3.9±0.8, Cr=2.8±0.5) (P 0.05). Conclusion: The results of this study add support to the view that the hippocampus may participate in the pathophysiology of PTSD, and the findings of volume and metabolite changes in the hippocampus has great value in diagnosing PTSD and in exploring the posibble pathophysiology mechanisms of hippocampus injure in PTSD. (authors)

High integrity software for nuclear power plants: Candidate guidelines, technical basis and research needs. Main report, Volume 2

International Nuclear Information System (INIS)

Seth, S.; Bail, W.; Cleaves, D.; Cohen, H.; Hybertson, D.; Schaefer, C.; Stark, G.; Ta, A.; Ulery, B.

1995-06-01

The work documented in this report was performed in support of the US Nuclear Regulatory Commission to examine the technical basis for candidate guidelines that could be considered in reviewing and evaluating high integrity computer e following software development and assurance activities: Requirements specification; design; coding; verification and validation, inclukding static analysis and dynamic testing; safety analysis; operation and maintenance; configuration management; quality assurance; and planning and management. Each activity (framework element) was subdivided into technical areas (framework subelements). The report describes the development of approximately 200 candidate guidelines that span the entire ran e identification, categorization and prioritization of technical basis for those candidate guidelines; and the identification, categorization and prioritization of research needs for improving the technical basis. The report has two volumes: Volume 1, Executive Summary includes an overview of the framwork and of each framework element, the complete set of candidate guidelines, the results of the assessment of the technical basis for each candidate guideline, and a discussion of research needs that support the regulatory function; this document, Volume 2, is the main report

High integrity software for nuclear power plants: Candidate guidelines, technical basis and research needs. Main report, Volume 2

Energy Technology Data Exchange (ETDEWEB)

Seth, S.; Bail, W.; Cleaves, D.; Cohen, H.; Hybertson, D.; Schaefer, C.; Stark, G.; Ta, A.; Ulery, B. [Mitre Corp., McLean, VA (United States)

1995-06-01

The work documented in this report was performed in support of the US Nuclear Regulatory Commission to examine the technical basis for candidate guidelines that could be considered in reviewing and evaluating high integrity computer e following software development and assurance activities: Requirements specification; design; coding; verification and validation, inclukding static analysis and dynamic testing; safety analysis; operation and maintenance; configuration management; quality assurance; and planning and management. Each activity (framework element) was subdivided into technical areas (framework subelements). The report describes the development of approximately 200 candidate guidelines that span the entire ran e identification, categorization and prioritization of technical basis for those candidate guidelines; and the identification, categorization and prioritization of research needs for improving the technical basis. The report has two volumes: Volume 1, Executive Summary includes an overview of the framwork and of each framework element, the complete set of candidate guidelines, the results of the assessment of the technical basis for each candidate guideline, and a discussion of research needs that support the regulatory function; this document, Volume 2, is the main report.

A Time Marching Scheme for Solving Volume Integral Equations on Nonlinear Scatterers

KAUST Repository

Bagci, Hakan

2015-01-07

Transient electromagnetic field interactions on inhomogeneous penetrable scatterers can be analyzed by solving time domain volume integral equations (TDVIEs). TDVIEs are oftentimes solved using marchingon-in-time (MOT) schemes. Unlike finite difference and finite element schemes, MOT-TDVIE solvers require discretization of only the scatterers, do not call for artificial absorbing boundary conditions, and are more robust to numerical phase dispersion. On the other hand, their computational cost is high, they suffer from late-time instabilities, and their implicit nature makes incorporation of nonlinear constitutive relations more difficult. Development of plane-wave time-domain (PWTD) and FFT-based schemes has significantly reduced the computational cost of the MOT-TDVIE solvers. Additionally, latetime instability problem has been alleviated for all practical purposes with the development of accurate integration schemes and specially designed temporal basis functions. Addressing the third challenge is the topic of this presentation. I will talk about an explicit MOT scheme developed for solving the TDVIE on scatterers with nonlinear material properties. The proposed scheme separately discretizes the TDVIE and the nonlinear constitutive relation between electric field intensity and flux density. The unknown field intensity and flux density are expanded using half and full Schaubert-Wilton-Glisson (SWG) basis functions in space and polynomial temporal interpolators in time. The resulting coupled system of the discretized TDVIE and constitutive relation is integrated in time using an explicit P E(CE) m scheme to yield the unknown expansion coefficients. Explicitness of time marching allows for straightforward incorporation of the nonlinearity as a function evaluation on the right hand side of the coupled system of equations. Consequently, the resulting MOT scheme does not call for a Newton-like nonlinear solver. Numerical examples, which demonstrate the applicability

A Time Marching Scheme for Solving Volume Integral Equations on Nonlinear Scatterers

KAUST Repository

Bagci, Hakan

2015-01-01

Transient electromagnetic field interactions on inhomogeneous penetrable scatterers can be analyzed by solving time domain volume integral equations (TDVIEs). TDVIEs are oftentimes solved using marchingon-in-time (MOT) schemes. Unlike finite difference and finite element schemes, MOT-TDVIE solvers require discretization of only the scatterers, do not call for artificial absorbing boundary conditions, and are more robust to numerical phase dispersion. On the other hand, their computational cost is high, they suffer from late-time instabilities, and their implicit nature makes incorporation of nonlinear constitutive relations more difficult. Development of plane-wave time-domain (PWTD) and FFT-based schemes has significantly reduced the computational cost of the MOT-TDVIE solvers. Additionally, latetime instability problem has been alleviated for all practical purposes with the development of accurate integration schemes and specially designed temporal basis functions. Addressing the third challenge is the topic of this presentation. I will talk about an explicit MOT scheme developed for solving the TDVIE on scatterers with nonlinear material properties. The proposed scheme separately discretizes the TDVIE and the nonlinear constitutive relation between electric field intensity and flux density. The unknown field intensity and flux density are expanded using half and full Schaubert-Wilton-Glisson (SWG) basis functions in space and polynomial temporal interpolators in time. The resulting coupled system of the discretized TDVIE and constitutive relation is integrated in time using an explicit P E(CE) m scheme to yield the unknown expansion coefficients. Explicitness of time marching allows for straightforward incorporation of the nonlinearity as a function evaluation on the right hand side of the coupled system of equations. Consequently, the resulting MOT scheme does not call for a Newton-like nonlinear solver. Numerical examples, which demonstrate the applicability

Genetic influences on schizophrenia and subcortical brain volumes

DEFF Research Database (Denmark)

Franke, Barbara; Stein, Jason L; Ripke, Stephan

2016-01-01

and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between...... genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk...

Functional Integration

Science.gov (United States)

Cartier, Pierre; DeWitt-Morette, Cecile

2010-06-01

Acknowledgements; List symbols, conventions, and formulary; Part I. The Physical and Mathematical Environment: 1. The physical and mathematical environment; Part II. Quantum Mechanics: 2. First lesson: gaussian integrals; 3. Selected examples; 4. Semiclassical expansion: WKB; 5. Semiclassical expansion: beyond WKB; 6. Quantum dynamics: path integrals and operator formalism; Part III. Methods from Differential Geometry: 7. Symmetries; 8. Homotopy; 9. Grassmann analysis: basics; 10. Grassmann analysis: applications; 11. Volume elements, divergences, gradients; Part IV. Non-Gaussian Applications: 12. Poisson processes in physics; 13. A mathematical theory of Poisson processes; 14. First exit time: energy problems; Part V. Problems in Quantum Field Theory: 15. Renormalization 1: an introduction; 16. Renormalization 2: scaling; 17. Renormalization 3: combinatorics; 18. Volume elements in quantum field theory Bryce DeWitt; Part VI. Projects: 19. Projects; Appendix A. Forward and backward integrals: spaces of pointed paths; Appendix B. Product integrals; Appendix C. A compendium of gaussian integrals; Appendix D. Wick calculus Alexander Wurm; Appendix E. The Jacobi operator; Appendix F. Change of variables of integration; Appendix G. Analytic properties of covariances; Appendix H. Feynman's checkerboard; Bibliography; Index.

Threshold corrections, generalised prepotentials and Eichler integrals

CERN Document Server

Angelantonj, Carlo; Pioline, Boris

2015-06-12

We continue our study of one-loop integrals associated to BPS-saturated amplitudes in $\\mathcal{N}=2$ heterotic vacua. We compute their large-volume behaviour, and express them as Fourier series in the complexified volume, with Fourier coefficients given in terms of Niebur-Poincar\\'e series in the complex structure modulus. The closure of Niebur-Poincar\\'e series under modular derivatives implies that such integrals derive from holomorphic prepotentials $f_n$, generalising the familiar prepotential of $\\mathcal{N}=2$ supergravity. These holomorphic prepotentials transform anomalously under T-duality, in a way characteristic of Eichler integrals. We use this observation to compute their quantum monodromies under the duality group. We extend the analysis to modular integrals with respect to Hecke congruence subgroups, which naturally arise in compactifications on non-factorisable tori and freely-acting orbifolds. In this case, we derive new explicit results including closed-form expressions for integrals involv...

High integrity software for nuclear power plants: Candidate guidelines, technical basis and research needs. Executive summary: Volume 1

International Nuclear Information System (INIS)

Seth, S.; Bail, W.; Cleaves, D.; Cohen, H.; Hybertson, D.; Schaefer, C.; Stark, G.; Ta, A.; Ulery, B.

1995-06-01

The work documented in this report was performed in support of the US Nuclear Regulatory Commission to examine the technical basis for candidate guidelines that could be considered in reviewing and evaluating high integrity computer software used in the safety systems of nuclear power plants. The framework for the work consisted of the following software development and assurance activities: requirements specification; design; coding; verification and validation, including static analysis and dynamic testing; safety analysis; operation and maintenance; configuration management; quality assurance; and planning and management. Each activity (framework element) was subdivided into technical areas (framework subelements). The report describes the development of approximately 200 candidate guidelines that span the entire range of software life-cycle activities; the assessment of the technical basis for those candidate guidelines; and the identification, categorization and prioritization of research needs for improving the technical basis. The report has two volumes: Volume 1, Executive Summary, includes an overview of the framework and of each framework element, the complete set of candidate guidelines, the results of the assessment of the technical basis for each candidate guideline, and a discussion of research needs that support the regulatory function; Volume 2 is the main report

Integrating over Higgs branches

International Nuclear Information System (INIS)

Moore, G.; Shatashvili, S.

2000-01-01

We develop some useful techniques for integrating over Higgs branches in supersymmetric theories with 4 and 8 supercharges. In particular, we define a regularized volume for hyperkaehler quotients. We evaluate this volume for certain ALE and ALF spaces in terms of the hyperkaehler periods. We also reduce these volumes for a large class of hyperkaehler quotients to simpler integrals. These quotients include complex coadjoint orbits, instanton moduli spaces on R 4 and ALE manifolds, Hitchin spaces, and moduli spaces of (parabolic) Higgs bundles on Riemann surfaces. In the case of Hitchin spaces the evaluation of the volume reduces to a summation over solutions of Bethe ansatz equations for the non-linear Schroedinger system. We discuss some applications of our results. (orig.)

A carbon emissions reduction index: Integrating the volume and allocation of regional emissions

International Nuclear Information System (INIS)

Chen, Jiandong; Cheng, Shulei; Song, Malin; Wu, Yinyin

2016-01-01

Highlights: • We build a carbon emissions reduction index (CERI). • The aim is to quantify the pressure on policymakers to reduce emissions. • Scale-related effects and carbon emissions allocations are included in the CERI. • Different standards of carbon emissions allocations are also considered. • We decompose the Gini coefficient to evaluate the effects of three factors. - Abstract: Given the acceleration of global warming and rising greenhouse gas emissions, all countries are facing the harsh reality of the need to reduce carbon emissions. In this study, we propose an index to quantify the pressure faced by policymakers to reduce such emissions, termed the carbon emissions reduction index. This index allows us to observe the effect of carbon emissions volume on the pressure faced by policymakers and study the impact of optimizing interregional carbon emissions on reducing this pressure. In addition, we account for several carbon emissions standards in constructing the index. We conclude that the variation in the index is likely to be attributable to carbon emissions volume, regional ranking, and population (population can also be replaced by GDP, resource endowment, or other factors). In addition, based on empirical data on the world’s largest emitter of carbon dioxide (China), this study analyzes the evolution of pressure to reduce emissions on a country’s policymakers. The results show that the growing volume and unsuitable allocation of carbon emissions from 1997 to 2012 imposed increasing pressure on the Chinese government in this regard. In addition, reductions in carbon emissions volume and regional ranking are primary factors that impact pressure on policymakers.

A volume integral equation solver for quantum-corrected transient analysis of scattering from plasmonic nanostructures

KAUST Repository

Sayed, Sadeed Bin; Uysal, Ismail Enes; Bagci, Hakan; Ulku, H. Arda

2018-01-01

Quantum tunneling is observed between two nanostructures that are separated by a sub-nanometer gap. Electrons “jumping” from one structure to another create an additional current path. An auxiliary tunnel is introduced between the two structures as a support for this so that a classical electromagnetic solver can account for the effects of quantum tunneling. The dispersive permittivity of the tunnel is represented by a Drude model, whose parameters are obtained from the electron tunneling probability. The transient scattering from the connected nanostructures (i.e., nanostructures plus auxiliary tunnel) is analyzed using a time domain volume integral equation solver. Numerical results demonstrating the effect of quantum tunneling on the scattered fields are provided.

Community energy systems and the law of public utilities. Volume thirty-eight. Oklahoma. Final report of a study of the impacts of regulations affecting the acceptance of integrated community energy systems

Energy Technology Data Exchange (ETDEWEB)

Feurer, D.A.; Weaver, C.L.

1981-01-01

A detailed description is given of the laws and programs of the State of Oklahoma governing the regulation of public energy utilities, the siting of energy generating and transmission facilities, the municipal franchising of public energy utilities, and the prescription of rates to be charged by utilities including attendant problems of cost allocations, rate base and operating expense determinations, and rate of return allowances. These laws and programs are analyzed to identify impediments which they may present to the implementation of Integrated Community Energy Systems (ICES). This report is one of fifty-one separate volumes which describe such regulatory programs at the Federal level and in each state as background to the report entitled Community Energy Systems and the Law of Public Utilities, Volume One: An Overview. This report also contains a summary of a strategy described in Volume One: An Overview for overcoming these impediments by working within the existing regulatory framework and by making changes in the regulatory programs to enhance the likelihood of ICES implementation.

Enhanced integrated nonthermal treatment system study

International Nuclear Information System (INIS)

Biagi, C.; Schwinkendorf, B.; Teheranian, B.

1997-02-01

The purpose of the Enhanced Nonthermal Treatment Systems (ENTS) study is to evaluate alternative configurations of one of the five systems evaluated in the Integrated Nonthermal Treatment Systems (INTS) study. Five alternative configurations are evaluated. Each is designed to enhance the final waste form performance by replacing grout with improved stabilization technologies, or to improve system performance by improving the destruction efficiency for organic contaminants. AU enhanced systems are alternative configurations of System NT-5, which has the following characteristics: Nonthermal System NT-5: (1) catalytic wet oxidation (CWO) to treat organic material including organic liquids, sludges, and soft (or combustible) debris, (2) thermal desorption of inorganic sludge and process residue, (3) washing of soil and inorganic debris with treatment by CWO of removed organic material, (4) metal decontamination by abrasive blasting, (5) stabilization of treated sludge, soil, debris, and untreated debris with entrained contamination in grout, and (6) stabilization of inorganic sludge, salts and secondary waste in polymer. System NT-5 was chosen because it was designed to treat combustible debris thereby minimizing the final waste form volume, and because it uses grout for primary stabilization. The enhanced nonthermal systems were studied to determine the cost and performance impact of replacing grout (a commonly used stabilization agent in the DOE complex) with improved waste stabilization methods such as vitrification and polymer

High Volume Manufacturing and Field Stability of MEMS Products

Science.gov (United States)

Martin, Jack

Low volume MEMS/NEMS production is practical when an attractive concept is implemented with business, manufacturing, packaging, and test support. Moving beyond this to high volume production adds requirements on design, process control, quality, product stability, market size, market maturity, capital investment, and business systems. In a broad sense, this chapter uses a case study approach: It describes and compares the silicon-based MEMS accelerometers, pressure sensors, image projection systems, and gyroscopes that are in high volume production. Although they serve several markets, these businesses have common characteristics. For example, the manufacturing lines use automated semiconductor equipment and standard material sets to make consistent products in large quantities. Standard, well controlled processes are sometimes modified for a MEMS product. However, novel processes that cannot run with standard equipment and material sets are avoided when possible. This reliance on semiconductor tools, as well as the organizational practices required to manufacture clean, particle-free products partially explains why the MEMS market leaders are integrated circuit manufacturers. There are other factors. MEMS and NEMS are enabling technologies, so it can take several years for high volume applications to develop. Indeed, market size is usually a strong function of price. This becomes a vicious circle, because low price requires low cost - a result that is normally achieved only after a product is in high volume production. During the early years, IC companies reduced cost and financial risk by using existing facilities for low volume MEMS production. As a result, product architectures are partially determined by capabilities developed for previous products. This chapter includes a discussion of MEMS product architecture with particular attention to the impact of electronic integration, packaging, and surfaces. Packaging and testing are critical, because they are

Biology as an Integrating Natural Science Domain

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 13; Issue 3. Biology as an Integrating Natural Science Domain: A Proposal for BSc (Hons) in Integrated Biology. Kambadur Muralidhar. Classroom Volume 13 Issue 3 March 2008 pp 272-276 ...

Improving integration for integrated coastal zone management: an eight country study.

Science.gov (United States)

Portman, M E; Esteves, L S; Le, X Q; Khan, A Z

2012-11-15

Integrated coastal zone management (ICZM) is a widely accepted approach for sustainable management of the coastal environment. ICZM emphasizes integration across sectors, levels of government, uses, stakeholders, and spatial and temporal scales. While improving integration is central to progress in ICZM, the role of and the achievement of integration remain understudied. To further study these two points, our research analyzes the performance of specific mechanisms used to support ICZM in eight countries (Belgium, India, Israel, Italy, Portugal, Sweden, UK, and Vietnam). The assessment is based on a qualitative comparative analysis conducted through the use of two surveys. It focuses on five ICZM mechanisms (environmental impact assessment; planning hierarchy; setback lines; marine spatial planning, and regulatory commission) and their role in improving integration. Our findings indicate that certain mechanisms enhance specific types of integration more effectively than others. Environmental impact assessment enhances science-policy integration and can be useful to integrate knowledge across sectors. Planning hierarchy and regulatory commissions are effective mechanisms to integrate policies across government levels, with the latter also promoting public-government integration. Setback lines can be applied to enhance integration across landscape units. Marine spatial planning is a multi-faceted mechanism with the potential to promote all types of integration. Policy-makers should adopt the mechanisms that are suited to the type of integration needed. Results of this study also contribute to evidence-based coastal management by identifying the most common impediments related to the mechanisms of integration in the eight studied countries. Copyright © 2012 Elsevier B.V. All rights reserved.

Multiloop integral system test (MIST)

International Nuclear Information System (INIS)

Gloudemans, J.R.

1989-07-01

The multiloop integral system test (MIST) was part of a multiphase program started in 1983 to address small-break loss-of-coolant accidents (SBLOCAs) specific to Babcock and Wilcox-designed plants. MIST was sponsored by the US Nuclear Regulatory Commission, the Babcock and Wilcox Owners Group, the Electric Power Research Institute, and Babcock and Wilcox. The unique features of the Babcock and Wilcox design, specifically the hot leg U-bends and steam generators, prevented the use of existing integral system data or existing integral system facilities to address the thermal-hydraulic SBLOCA questions. MIST and two other supporting facilities were specifically designed and constructed for this program, and an existing facility -- the once-through integral system (OTIS) -- was also used. Data from MIST and the other facilities will be used to benchmark the adequacy of system codes, such as RELAP5 and TRAC, for predicting abnormal plant transients. The individual tests are described in detail in Volumes 2 through 8 and Volume 11, and are summarized in Volume 1. Inter-group comparisons are addressed in this document, Volume 9. These comparisons are grouped as follows: mapping versus SBLOCA transients, SBLOCA, pump effects, and the effects of noncondensible gases. Appendix A provides an index and description of the microfiched plots for each test, which are enclosed with the corresponding Volumes 2 through 8. 147 figs., 5 tabs

Trans-Caspian gas pipeline feasibility study. Volume 1

International Nuclear Information System (INIS)

1999-01-01

This study, conducted by Enron Engineering and Construction Company, was funded by the US Trade and Development Agency. The study provides detailed information concerning natural gas demand in Turkey and Southern Europe. The purpose of the study is to estimate the rate at which new gas can be absorbed in the Turkish market and be re-exported to the markets in Europe, as well as to forecast Turkish natural gas demand for the period up to 2020. The study also evaluates gas demand and pricing for the market in the 2002--2005 time frame. This is Volume 1 of a 3-volume report, and is divided into the following sections: (1) Task A: Gas Sales; (2) Task B: Initial Economic Screening; (3) Task D: Project Cost Analysis

Comprehensive Cooling Water Study. Volume 1. Summary of environmental effects, Savannah River Plant. Annual report

International Nuclear Information System (INIS)

Gladden, J.B.; Lower, M.W.; Mackey, H.E.; Specht, W.L.; Wilde, E.W.

1985-07-01

This volume summarizes the technical content of Volumes II through XI of the annual report. Volume II provides a description of the SRP environment, facilities, and operation, and presents the objectives and design for the CCWS. Volume III presents information on water quality of SRP surface waters. Results of radionuclide and heavy metal transport studies are presented in Volume IV. Volume V contains findings from studies of wetland plant communities. Volume VI presents findings from studies of the lower food chain components of SRP aquatic habitats. The results of fisheries studies are reported in Volume VII. Studies of semi-aquatic vertebrate populations are reported in Volume VIII. Water-fowl utilization of SRP habitats is discussed in Volume IX. The status of endangered species that utilize SRP aquatic habitats is presented in Volume X. The findings from studies of Parr Pond ecosystem are presented in Volume XI

Life sciences payload definition and integration study. Volume 1: Executive summary. [carry-on laboratory for Spacelab

Science.gov (United States)

1974-01-01

The definition and integration tasks involved in the development of design concepts for a carry-on laboratory (COL), to be compatible with Spacelab operations, were divided into the following study areas: (1) identification of research and equipment requirements of the COL; (2) development of a number of conceptual layouts for COL based on the defined research of final conceptual designs; and (4) development of COL planning information for definition of COL/Spacelab interface data, cost data, and program cost schedules, including design drawings of a selected COL to permit fabrication of a functional breadboard.

Threshold corrections, generalised prepotentials and Eichler integrals

Directory of Open Access Journals (Sweden)

Carlo Angelantonj

2015-08-01

Full Text Available We continue our study of one-loop integrals associated to BPS-saturated amplitudes in N=2 heterotic vacua. We compute their large-volume behaviour, and express them as Fourier series in the complexified volume, with Fourier coefficients given in terms of Niebur–Poincaré series in the complex structure modulus. The closure of Niebur–Poincaré series under modular derivatives implies that such integrals derive from holomorphic prepotentials fn, generalising the familiar prepotential of N=2 supergravity. These holomorphic prepotentials transform anomalously under T-duality, in a way characteristic of Eichler integrals. We use this observation to compute their quantum monodromies under the duality group. We extend the analysis to modular integrals with respect to Hecke congruence subgroups, which naturally arise in compactifications on non-factorisable tori and freely-acting orbifolds. In this case, we derive new explicit results including closed-form expressions for integrals involving the Γ0(N Hauptmodul, a full characterisation of holomorphic prepotentials including their quantum monodromies, as well as concrete formulæ for holomorphic Yukawa couplings.

Novel genetic loci associated with hippocampal volume.

Science.gov (United States)

Hibar, Derrek P; Adams, Hieab H H; Jahanshad, Neda; Chauhan, Ganesh; Stein, Jason L; Hofer, Edith; Renteria, Miguel E; Bis, Joshua C; Arias-Vasquez, Alejandro; Ikram, M Kamran; Desrivières, Sylvane; Vernooij, Meike W; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf; Andersson, Micael; Arfanakis, Konstantinos; Aribisala, Benjamin S; Armstrong, Nicola J; Athanasiu, Lavinia; Axelsson, Tomas; Beecham, Ashley H; Beiser, Alexa; Bernard, Manon; Blanton, Susan H; Bohlken, Marc M; Boks, Marco P; Bralten, Janita; Brickman, Adam M; Carmichael, Owen; Chakravarty, M Mallar; Chen, Qiang; Ching, Christopher R K; Chouraki, Vincent; Cuellar-Partida, Gabriel; Crivello, Fabrice; Den Braber, Anouk; Doan, Nhat Trung; Ehrlich, Stefan; Giddaluru, Sudheer; Goldman, Aaron L; Gottesman, Rebecca F; Grimm, Oliver; Griswold, Michael E; Guadalupe, Tulio; Gutman, Boris A; Hass, Johanna; Haukvik, Unn K; Hoehn, David; Holmes, Avram J; Hoogman, Martine; Janowitz, Deborah; Jia, Tianye; Jørgensen, Kjetil N; Karbalai, Nazanin; Kasperaviciute, Dalia; Kim, Sungeun; Klein, Marieke; Kraemer, Bernd; Lee, Phil H; Liewald, David C M; Lopez, Lorna M; Luciano, Michelle; Macare, Christine; Marquand, Andre F; Matarin, Mar; Mather, Karen A; Mattheisen, Manuel; McKay, David R; Milaneschi, Yuri; Muñoz Maniega, Susana; Nho, Kwangsik; Nugent, Allison C; Nyquist, Paul; Loohuis, Loes M Olde; Oosterlaan, Jaap; Papmeyer, Martina; Pirpamer, Lukas; Pütz, Benno; Ramasamy, Adaikalavan; Richards, Jennifer S; Risacher, Shannon L; Roiz-Santiañez, Roberto; Rommelse, Nanda; Ropele, Stefan; Rose, Emma J; Royle, Natalie A; Rundek, Tatjana; Sämann, Philipp G; Saremi, Arvin; Satizabal, Claudia L; Schmaal, Lianne; Schork, Andrew J; Shen, Li; Shin, Jean; Shumskaya, Elena; Smith, Albert V; Sprooten, Emma; Strike, Lachlan T; Teumer, Alexander; Tordesillas-Gutierrez, Diana; Toro, Roberto; Trabzuni, Daniah; Trompet, Stella; Vaidya, Dhananjay; Van der Grond, Jeroen; Van der Lee, Sven J; Van der Meer, Dennis; Van Donkelaar, Marjolein M J; Van Eijk, Kristel R; Van Erp, Theo G M; Van Rooij, Daan; Walton, Esther; Westlye, Lars T; Whelan, Christopher D; Windham, Beverly G; Winkler, Anderson M; Wittfeld, Katharina; Woldehawariat, Girma; Wolf, Christiane; Wolfers, Thomas; Yanek, Lisa R; Yang, Jingyun; Zijdenbos, Alex; Zwiers, Marcel P; Agartz, Ingrid; Almasy, Laura; Ames, David; Amouyel, Philippe; Andreassen, Ole A; Arepalli, Sampath; Assareh, Amelia A; Barral, Sandra; Bastin, Mark E; Becker, Diane M; Becker, James T; Bennett, David A; Blangero, John; van Bokhoven, Hans; Boomsma, Dorret I; Brodaty, Henry; Brouwer, Rachel M; Brunner, Han G; Buckner, Randy L; Buitelaar, Jan K; Bulayeva, Kazima B; Cahn, Wiepke; Calhoun, Vince D; Cannon, Dara M; Cavalleri, Gianpiero L; Cheng, Ching-Yu; Cichon, Sven; Cookson, Mark R; Corvin, Aiden; Crespo-Facorro, Benedicto; Curran, Joanne E; Czisch, Michael; Dale, Anders M; Davies, Gareth E; De Craen, Anton J M; De Geus, Eco J C; De Jager, Philip L; De Zubicaray, Greig I; Deary, Ian J; Debette, Stéphanie; DeCarli, Charles; Delanty, Norman; Depondt, Chantal; DeStefano, Anita; Dillman, Allissa; Djurovic, Srdjan; Donohoe, Gary; Drevets, Wayne C; Duggirala, Ravi; Dyer, Thomas D; Enzinger, Christian; Erk, Susanne; Espeseth, Thomas; Fedko, Iryna O; Fernández, Guillén; Ferrucci, Luigi; Fisher, Simon E; Fleischman, Debra A; Ford, Ian; Fornage, Myriam; Foroud, Tatiana M; Fox, Peter T; Francks, Clyde; Fukunaga, Masaki; Gibbs, J Raphael; Glahn, David C; Gollub, Randy L; Göring, Harald H H; Green, Robert C; Gruber, Oliver; Gudnason, Vilmundur; Guelfi, Sebastian; Håberg, Asta K; Hansell, Narelle K; Hardy, John; Hartman, Catharina A; Hashimoto, Ryota; Hegenscheid, Katrin; Heinz, Andreas; Le Hellard, Stephanie; Hernandez, Dena G; Heslenfeld, Dirk J; Ho, Beng-Choon; Hoekstra, Pieter J; Hoffmann, Wolfgang; Hofman, Albert; Holsboer, Florian; Homuth, Georg; Hosten, Norbert; Hottenga, Jouke-Jan; Huentelman, Matthew; Hulshoff Pol, Hilleke E; Ikeda, Masashi; Jack, Clifford R; Jenkinson, Mark; Johnson, Robert; Jönsson, Erik G; Jukema, J Wouter; Kahn, René S; Kanai, Ryota; Kloszewska, Iwona; Knopman, David S; Kochunov, Peter; Kwok, John B; Lawrie, Stephen M; Lemaître, Hervé; Liu, Xinmin; Longo, Dan L; Lopez, Oscar L; Lovestone, Simon; Martinez, Oliver; Martinot, Jean-Luc; Mattay, Venkata S; McDonald, Colm; McIntosh, Andrew M; McMahon, Francis J; McMahon, Katie L; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Mohnke, Sebastian; Montgomery, Grant W; Morris, Derek W; Mosley, Thomas H; Mühleisen, Thomas W; Müller-Myhsok, Bertram; Nalls, Michael A; Nauck, Matthias; Nichols, Thomas E; Niessen, Wiro J; Nöthen, Markus M; Nyberg, Lars; Ohi, Kazutaka; Olvera, Rene L; Ophoff, Roel A; Pandolfo, Massimo; Paus, Tomas; Pausova, Zdenka; Penninx, Brenda W J H; Pike, G Bruce; Potkin, Steven G; Psaty, Bruce M; Reppermund, Simone; Rietschel, Marcella; Roffman, Joshua L; Romanczuk-Seiferth, Nina; Rotter, Jerome I; Ryten, Mina; Sacco, Ralph L; Sachdev, Perminder S; Saykin, Andrew J; Schmidt, Reinhold; Schmidt, Helena; Schofield, Peter R; Sigursson, Sigurdur; Simmons, Andrew; Singleton, Andrew; Sisodiya, Sanjay M; Smith, Colin; Smoller, Jordan W; Soininen, Hilkka; Steen, Vidar M; Stott, David J; Sussmann, Jessika E; Thalamuthu, Anbupalam; Toga, Arthur W; Traynor, Bryan J; Troncoso, Juan; Tsolaki, Magda; Tzourio, Christophe; Uitterlinden, Andre G; Hernández, Maria C Valdés; Van der Brug, Marcel; van der Lugt, Aad; van der Wee, Nic J A; Van Haren, Neeltje E M; van 't Ent, Dennis; Van Tol, Marie-Jose; Vardarajan, Badri N; Vellas, Bruno; Veltman, Dick J; Völzke, Henry; Walter, Henrik; Wardlaw, Joanna M; Wassink, Thomas H; Weale, Michael E; Weinberger, Daniel R; Weiner, Michael W; Wen, Wei; Westman, Eric; White, Tonya; Wong, Tien Y; Wright, Clinton B; Zielke, Ronald H; Zonderman, Alan B; Martin, Nicholas G; Van Duijn, Cornelia M; Wright, Margaret J; Longstreth, W T; Schumann, Gunter; Grabe, Hans J; Franke, Barbara; Launer, Lenore J; Medland, Sarah E; Seshadri, Sudha; Thompson, Paul M; Ikram, M Arfan

2017-01-18

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r g =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

Trans-Caspian gas pipeline feasibility study. Volume 3

International Nuclear Information System (INIS)

1999-01-01

This study, conducted by Enron Engineering and Construction Company, was funded by the US Trade and Development Agency. The study provides detailed information concerning natural gas demand in Turkey and Southern Europe. The purpose of the study is to estimate the rate at which new gas can be absorbed in the Turkish market and be re-exported to the markets in Europe, as well as to forecast Turkish natural gas demand for the period up to 2020. The study also evaluates gas demand and pricing for the market in the 2002--2005 time frame. This is Volume 3 of a 3-volume report, and it is divided into the following sections: (1) Executive Summary; (2) Task C: Technical Feasibility and Preliminary Design; (3) Task F: Project Implementation Strategy

Transient analysis of electromagnetic wave interactions on high-contrast scatterers using volume electric field integral equation

KAUST Repository

Sayed, Sadeed Bin

2014-07-01

A marching on-in-time (MOT)-based time domain volume electric field integral equation (TD-VEFIE) solver is proposed for accurate and stable analysis of electromagnetic wave interactions on high-contrast scatterers. The stability is achieved using band-limited but two-sided (non-causal) temporal interpolation functions and an extrapolation scheme to cast the time marching into a causal form. The extrapolation scheme is designed to be highly accurate for oscillating and exponentially decaying fields, hence it accurately captures the physical behavior of the resonant modes that are excited inside the dielectric scatterer. Numerical results demonstrate that the resulting MOT scheme maintains its stability as the number of resonant modes increases with the contrast of the scatterer.

Volumizing effects of a smooth, highly cohesive, viscous 20-mg/mL hyaluronic acid volumizing filler: prospective European study

Directory of Open Access Journals (Sweden)

Hoffmann Klaus

2009-08-01

Full Text Available Abstract Background Facial volume loss contributes significantly to facial aging. The 20-mg/mL hyaluronic acid (HA formulation used in this study is a smooth, highly cohesive, viscous, fully reversible, volumizing filler indicated to restore facial volume. This first prospective study evaluated use in current aesthetic clinical practice. Methods A pan-European evaluation conducted under guidelines of the World Association of Opinion and Marketing Research, the trial comprised a baseline visit (visit 1 and a follow-up (visit 2 at 14 ± 7 days posttreatment. Physicians photographed patients at each visit. Each patient was treated with the 20-mg/mL HA volumizing filler as supplied in standard packaging. Procedural details, aesthetic outcomes, safety, and physician and patient ratings of their experience were recorded. Results Fifteen physicians and 70 patients (91% female; mean age: 50 years participated. Mean volume loss at baseline was 3.7 (moderate on the Facial Volume Loss Scale. Local anesthesia was used in 64.3% of cases. Most injections (85% were administered with needles rather than cannulas. Of the 208 injections, 59% were in the malar region, primarily above the periosteum. Subcutaneous injections were most common for other sites. The mean total injection volume per patient was 4.6 mL. The mean volume loss score declined significantly (P Conclusion The 20-mg/mL smooth, highly cohesive, viscous, volumizing HA filler was effective, well tolerated, and easy to use in current clinical practice. Participants were very likely to recommend this product to colleagues and friends, and patients would be very or quite likely to request this product for future treatments.

Study on the High Volume Reduction of Radioactive Wastes

Energy Technology Data Exchange (ETDEWEB)

Kim, Ki Hong; Sik, Kang Il; Seok, Hong Dae [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Ho, Jeon Gil [RADIN Co. Ltd., Daejeon (Korea, Republic of)

2013-10-15

The solidification of radioactive wastes by the mixing method always increases their volume due to the limitation of incorporation ratio (waste/solidification agent). But if the powdered wastes can be compacted as the high density pellets and also the pellets can be filled up in a waste drum as much as possible while solidifying them with a very sticky solidification agent including a void formed in the filling step of pellets, it might be more desirable to reduce the waste volume as compared with the mixing method. So in this study, we designed and manufactured a high volume reduction machine which has the special size and shape of a pellet pocket, which the pellets can be extracted from easily and filled up in a large amount in drum, a pressurizing device to press 2 rolls, and the uniform feeding device of powder to the roll tyre. Some operational parameters which affect the formation of pellets from a powder were investigated, and then the volume reduction of a powder was evaluated. The briquetting machine, popular in general industry, was modified to apply for the volume reduction of the powered radioactive wastes (dried concentrate, sludge, spent ion-exchange resin, ash, depleted uranium powder, and etc.). In this developed high volume reduction machine, the capacity was 25 ∼ 62.5 kg/h at the optimum conditions, and the estimated volume reduction was about 2.95 (2.74/0.93) on the basis of between a powder (bulk density = 0.93 g/cm{sup 3}) and the pellet (2.74 g/cm{sup 3}). But on the basis of 200L drum, the calculated volume reduction was about 1.34 in consideration of a void volume originated in the filling step of the pellets.

An experimental study on the excitation of large volume airguns in a small volume body of water

International Nuclear Information System (INIS)

Wang, Baoshan; Yang, Wei; Yuan, Songyong; Ge, Hongkui; Chen, Yong; Guo, Shijun; Xu, Ping

2010-01-01

A large volume airgun array is effective in generating seismic waves, which is extensively used in large volume bodies of water such as oceans, lakes and reservoirs. So far, the application of large volume airguns is subject to the distribution of large volume bodies of water. This paper reports an attempt to utilize large volume airguns in a small body of water as a seismic source for seismotectonic studies. We carried out a field experiment in Mapaoquan pond, Fangshan district, Beijing, during the period 25–30 May 2009. Bolt LL1500 airguns, each with volumes of 2000 in 3 , the largest commercial airguns available today, were used in this experiment. We tested the excitation of the airgun array with one or two guns. The airgun array was placed 7–11 m below the water's surface. The near- and far-field seismic motions induced by the airgun source were recorded by a 100 km long seismic profile composed of 16 portable seismometers and a 100 m long strong motion seismograph profile, respectively. The following conclusions can be drawn from this experiment. First, it is feasible to excite large volume airguns in a small volume body of water. Second, seismic signals from a single shot of one airgun can be recognized at the offset up to 15 km. Taking advantage of high source repeatability, we stacked records from 128 shots to enhance the signal-to-noise ratio, and direct P-waves can be easily identified at the offset ∼50 km in stacked records. Third, no detectable damage to fish or near-field constructions was caused by the airgun shots. Those results suggest that large volume airguns excited in small bodies of water can be used as a routinely operated seismic source for mid-scale (tens of kilometres) subsurface explorations and monitoring under various running conditions

The MASSIVE survey. I. A volume-limited integral-field spectroscopic study of the most massive early-type galaxies within 108 Mpc

Energy Technology Data Exchange (ETDEWEB)

Ma, Chung-Pei [Department of Astronomy, University of California, Berkeley, CA 94720 (United States); Greene, Jenny E.; Murphy, Jeremy D. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); McConnell, Nicholas [Institute for Astronomy, University of Hawaii at Manoa, Honolulu, HI 96822 (United States); Janish, Ryan [Department of Physics, University of California, Berkeley, CA 94720 (United States); Blakeslee, John P. [Dominion Astrophysical Observatory, NRC Herzberg Institute of Astrophysics, Victoria, BC V9E 2E7 (Canada); Thomas, Jens, E-mail: cpma@berkeley.edu [Max Planck-Institute for Extraterrestrial Physics, Giessenbachstr. 1, D-85741 Garching (Germany)

2014-11-10

Massive early-type galaxies represent the modern day remnants of the earliest major star formation episodes in the history of the universe. These galaxies are central to our understanding of the evolution of cosmic structure, stellar populations, and supermassive black holes, but the details of their complex formation histories remain uncertain. To address this situation, we have initiated the MASSIVE Survey, a volume-limited, multi-wavelength, integral-field spectroscopic (IFS) and photometric survey of the structure and dynamics of the ∼100 most massive early-type galaxies within a distance of 108 Mpc. This survey probes a stellar mass range M* ≳ 10{sup 11.5} M {sub ☉} and diverse galaxy environments that have not been systematically studied to date. Our wide-field IFS data cover about two effective radii of individual galaxies, and for a subset of them, we are acquiring additional IFS observations on sub-arcsecond scales with adaptive optics. We are also acquiring deep K-band imaging to trace the extended halos of the galaxies and measure accurate total magnitudes. Dynamical orbit modeling of the combined data will allow us to simultaneously determine the stellar, black hole, and dark matter halo masses. The primary goals of the project are to constrain the black hole scaling relations at high masses, investigate systematically the stellar initial mass function and dark matter distribution in massive galaxies, and probe the late-time assembly of ellipticals through stellar population and kinematical gradients. In this paper, we describe the MASSIVE sample selection, discuss the distinct demographics and structural and environmental properties of the selected galaxies, and provide an overview of our basic observational program, science goals and early survey results.

Volume 2. Probabilistic analysis of HTGR application studies. Supporting data

International Nuclear Information System (INIS)

1980-09-01

Volume II, Probabilistic Analysis of HTGR Application Studies - Supporting Data, gives the detail data, both deterministic and probabilistic, employed in the calculation presented in Volume I. The HTGR plants and the fossil plants considered in the study are listed. GCRA provided the technical experts from which the data were obtained by MAC personnel. The names of the technical experts (interviewee) and the analysts (interviewer) are given for the probabilistic data

Blanket comparison and selection study. Volume II

International Nuclear Information System (INIS)

1983-10-01

This volume contains extensive data for the following chapters: (1) solid breeder tritium recovery, (2) solid breeder blanket designs, (3) alternate blanket concept screening, and (4) safety analysis. The following appendices are also included: (1) blanket design guidelines, (2) power conversion systems, (3) helium-cooled, vanadium alloy structure blanket design, (4) high wall loading study, and (5) molten salt safety studies

Novel genetic loci associated with hippocampal volume

OpenAIRE

Hibar, Derrek P.; Adams, Hieab H. H.; Jahanshad, Neda; Chauhan, Ganesh; Stein, Jason L.; Hofer, Edith; Renteria, Miguel E.; Bis, Joshua C.; Arias-Vasquez, Alejandro; Ikram, M. Kamran; Desrivieres, Sylvane; Vernooij, Meike W.; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf

2017-01-01

International audience; The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal ...

The invisible hand illusion: multisensory integration leads to the embodiment of a discrete volume of empty space.

Science.gov (United States)

Guterstam, Arvid; Gentile, Giovanni; Ehrsson, H Henrik

2013-07-01

The dynamic integration of signals from different sensory modalities plays a key role in bodily self-perception. When visual information is used in the multisensory process of localizing and identifying one's own limbs, the sight of a body part often plays a dominant role. For example, it has repeatedly been shown that a viewed object must resemble a humanoid body part to permit illusory self-attribution of that object. Here, we report a perceptual illusion that challenges these assumptions by demonstrating that healthy (nonamputated) individuals can refer somatic sensations to a discrete volume of empty space and experience having an invisible hand. In 10 behavioral and one fMRI experiment, we characterized the perceptual rules and multisensory brain mechanisms that produced this "invisible hand illusion." Our behavioral results showed that the illusion depends on visuotactile-proprioceptive integration that obeys key spatial and temporal multisensory rules confined to near-personal space. The fMRI results associate the illusion experience with increased activity in regions related to the integration of multisensory body-related signals, most notably the bilateral ventral premotor, intraparietal, and cerebellar cortices. We further showed that a stronger feeling of having an invisible hand is associated with a higher degree of effective connectivity between the intraparietal and ventral premotor cortices. These findings demonstrate that the integration of temporally and spatially congruent multisensory signals in a premotor-intraparietal circuit is sufficient to redefine the spatial boundaries of the bodily self, even when visual information directly contradicts the presence of a physical limb at the location of the perceived illusory hand.

Volume dose of organs at risk in the irradiated volume

International Nuclear Information System (INIS)

Hishikawa, Yoshio; Tanaka, Shinichi; Miura, Takashi

1984-01-01

Absorbed dose of organs at risk in the 50% irradiated volume needs to be carefully monitored because there is high risk of radiation injury. This paper reports on the histogram of threedimensional volume dose of organs at risk, which is obtained by computer calculation of CT scans. In order to obtain this histogram, CT is first performed in the irradiation field. The dose in each pixel is then examined by the computer as to each slice. After the pixels of all slices in the organ at risk of the irradiated field are classified according to the doses, the number of pixels in the same dose class is counted. The result is expressed in a histogram. The histogram can show the differences of influence to organs at risk given by various radiation treatment techniques. Total volume dose of organs at risk after radiotherapy can also be obtained by integration of each dose of different treatment techniques. (author)

Probabilistic risk assessment of the Space Shuttle. Phase 3: A study of the potential of losing the vehicle during nominal operation. Volume 4: System models and data analysis

Science.gov (United States)

Fragola, Joseph R.; Maggio, Gaspare; Frank, Michael V.; Gerez, Luis; Mcfadden, Richard H.; Collins, Erin P.; Ballesio, Jorge; Appignani, Peter L.; Karns, James J.

1995-01-01

In this volume, volume 4 (of five volumes), the discussion is focussed on the system models and related data references and has the following subsections: space shuttle main engine, integrated solid rocket booster, orbiter auxiliary power units/hydraulics, and electrical power system.

Altered gray matter volume and white matter integrity in college students with mobile phone dependence

Directory of Open Access Journals (Sweden)

Yongming eWang

2016-05-01

Full Text Available Mobile phone dependence (MPD is a behavioral addiction that has become an increasing public mental health issue. While previous research has explored some of the factors that may predict MPD, the underlying neural mechanisms of MPD have not been investigated yet. The current study aimed to explore the microstructural variations associated with MPD as measured with functional Magnetic Resonance Imaging (fMRI. Gray matter volume (GMV and white matter (WM integrity (four indexes: fractional anisotropy, FA; mean diffusivity, MD; axial diffusivity, AD; and radial diffusivity, RD were calculated via voxel-based morphometry (VBM and tract-based spatial statistics (TBSS analysis, respectively. Sixty-eight college students (42 female were enrolled and separated into two groups (MPD group, N=34; control group, N=34 based on Mobile Phone Addiction Index (MPAI scale score. Trait impulsivity was also measured using the Barrett Impulsivity Scale (BIS-11. In light of underlying trait impulsivity, results revealed decreased GMV in the MPD group relative to controls in regions such as the right superior frontal gyrus (sFG, right inferior frontal gyrus (iFG, and bilateral thalamus (Thal. In the MPD group, GMV in the above mentioned regions was negatively correlated with scores on the MPAI. Results also showed significantly less FA and AD measures of white matter integrity in the MPD group relative to controls in bilateral hippocampal cingulum bundle fibers (CgH. Additionally, in the MPD group, FA of the CgH was also negatively correlated with scores on the MPAI. These findings provide the first morphological evidence of altered brain structure with phone-overuse, and may help to better understand the neural mechanisms of MPD in relation with other behavioral and substance addiction disorders.

Altered Gray Matter Volume and White Matter Integrity in College Students with Mobile Phone Dependence.

Science.gov (United States)

Wang, Yongming; Zou, Zhiling; Song, Hongwen; Xu, Xiaodan; Wang, Huijun; d'Oleire Uquillas, Federico; Huang, Xiting

2016-01-01

Mobile phone dependence (MPD) is a behavioral addiction that has become an increasing public mental health issue. While previous research has explored some of the factors that may predict MPD, the underlying neural mechanisms of MPD have not been investigated yet. The current study aimed to explore the microstructural variations associated with MPD as measured with functional Magnetic Resonance Imaging (fMRI). Gray matter volume (GMV) and white matter (WM) integrity [four indices: fractional anisotropy (FA); mean diffusivity (MD); axial diffusivity (AD); and radial diffusivity (RD)] were calculated via voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analysis, respectively. Sixty-eight college students (42 female) were enrolled and separated into two groups [MPD group, N = 34; control group (CG), N = 34] based on Mobile Phone Addiction Index (MPAI) scale score. Trait impulsivity was also measured using the Barratt Impulsiveness Scale (BIS-11). In light of underlying trait impulsivity, results revealed decreased GMV in the MPD group relative to controls in regions such as the right superior frontal gyrus (sFG), right inferior frontal gyrus (iFG), and bilateral thalamus (Thal). In the MPD group, GMV in the above mentioned regions was negatively correlated with scores on the MPAI. Results also showed significantly less FA and AD measures of WM integrity in the MPD group relative to controls in bilateral hippocampal cingulum bundle fibers (CgH). Additionally, in the MPD group, FA of the CgH was also negatively correlated with scores on the MPAI. These findings provide the first morphological evidence of altered brain structure with mobile phone overuse, and may help to better understand the neural mechanisms of MPD in relation to other behavioral and substance addiction disorders.

Altered Gray Matter Volume and White Matter Integrity in College Students with Mobile Phone Dependence

Science.gov (United States)

Wang, Yongming; Zou, Zhiling; Song, Hongwen; Xu, Xiaodan; Wang, Huijun; d’Oleire Uquillas, Federico; Huang, Xiting

2016-01-01

Mobile phone dependence (MPD) is a behavioral addiction that has become an increasing public mental health issue. While previous research has explored some of the factors that may predict MPD, the underlying neural mechanisms of MPD have not been investigated yet. The current study aimed to explore the microstructural variations associated with MPD as measured with functional Magnetic Resonance Imaging (fMRI). Gray matter volume (GMV) and white matter (WM) integrity [four indices: fractional anisotropy (FA); mean diffusivity (MD); axial diffusivity (AD); and radial diffusivity (RD)] were calculated via voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analysis, respectively. Sixty-eight college students (42 female) were enrolled and separated into two groups [MPD group, N = 34; control group (CG), N = 34] based on Mobile Phone Addiction Index (MPAI) scale score. Trait impulsivity was also measured using the Barratt Impulsiveness Scale (BIS-11). In light of underlying trait impulsivity, results revealed decreased GMV in the MPD group relative to controls in regions such as the right superior frontal gyrus (sFG), right inferior frontal gyrus (iFG), and bilateral thalamus (Thal). In the MPD group, GMV in the above mentioned regions was negatively correlated with scores on the MPAI. Results also showed significantly less FA and AD measures of WM integrity in the MPD group relative to controls in bilateral hippocampal cingulum bundle fibers (CgH). Additionally, in the MPD group, FA of the CgH was also negatively correlated with scores on the MPAI. These findings provide the first morphological evidence of altered brain structure with mobile phone overuse, and may help to better understand the neural mechanisms of MPD in relation to other behavioral and substance addiction disorders. PMID:27199831

Study of MHD stability beta limit in LHD by hierarchy integrated simulation code

International Nuclear Information System (INIS)

Sato, M.; Watanabe, K.Y.; Nakamura, Y.

2008-10-01

The beta limit by the ideal MHD instabilities (so-called 'MHD stability beta limit') for helical plasmas is studied by a hierarchy integrated simulation code. A numerical model for the effect of the MHD instabilities is introduced such that the pressure profile is flattened around the rational surface due to the MHD instabilities. The width of the flattening of the pressure gradient is determined from the width of the eigenmode structure of the MHD instabilities. It is assumed that there is the upper limit of the mode number of the MHD instabilities which directly affect the pressure gradient. The upper limit of the mode number is determined using a recent high beta experiment in the Large Helical Device (LHD). The flattening of the pressure gradient is calculated by the transport module in a hierarchy integrated code. The achievable volume averaged beta value in the LHD is expected to be beyond 6%. (author)

Longitudinal study of hippocampal volumes in heavy cannabis users.

Science.gov (United States)

Koenders, L; Lorenzetti, V; de Haan, L; Suo, C; Vingerhoets, Wam; van den Brink, W; Wiers, R W; Meijer, C J; Machielsen, Mwj; Goudriaan, A E; Veltman, D J; Yücel, M; Cousijn, J

2017-08-01

Cannabis exposure, particularly heavy cannabis use, has been associated with neuroanatomical alterations in regions rich with cannabinoid receptors such as the hippocampus in some but not in other (mainly cross-sectional) studies. However, it remains unclear whether continued heavy cannabis use alters hippocampal volume, and whether an earlier age of onset and/or a higher dosage exacerbate these changes. Twenty heavy cannabis users (mean age 21 years, range 18-24 years) and 23 matched non-cannabis using healthy controls were submitted to a comprehensive psychological assessment and magnetic resonance imaging scan at baseline and at follow-up (average of 39 months post-baseline; standard deviation=2.4). Cannabis users started smoking around 16 years and smoked on average five days per week. A novel aspect of the current study is that hippocampal volume estimates were obtained from manual tracing the hippocampus on T1-weighted anatomical magnetic resonance imaging scans, using a previously validated protocol. Compared to controls, cannabis users did not show hippocampal volume alterations at either baseline or follow-up. Hippocampal volumes increased over time in both cannabis users and controls, following similar trajectories of increase. Cannabis dose and age of onset of cannabis use did not affect hippocampal volumes. Continued heavy cannabis use did not affect hippocampal neuroanatomical changes in early adulthood. This contrasts with prior evidence on alterations in this region in samples of older adult cannabis users. In young adults using cannabis at this level, cannabis use may not be heavy enough to affect hippocampal neuroanatomy.

Petroleum industry in Latin America: volume I

International Nuclear Information System (INIS)

Reinsch, A.E.; Tissot, R.R.

1995-01-01

This first volume of a three-volume series, provided an overview of major economic trends, and energy reserves (i.e. crude oil, natural gas and electricity) in Latin America. Established crude oil reserves were estimated at 125 billion barrels, with Mexico and Venezuela accounting for over 90 percent of the total. Established natural gas reserves were estimated at 249 Tcf, roughly one half of it being in Venezuela. It was noted that since natural gas exploration was still in its infancy in the region, this figure was very likely an underestimate of available resources. The current physical and market characteristics of the petroleum sector in each of the seven Latin American countries were examined in detail, as were the legal, regulatory, fiscal and political environments. Latin American efforts at integration were examined, with emphasis on regional trade agreements and energy integration. The central conclusion of the study was that Latin America appeared poised for a period of sustained economic development, with the energy sector occupying center stage. tabs., figs., refs

Commutators of Integral Operators with Variable Kernels on Hardy ...

Indian Academy of Sciences (India)

Home; Journals; Proceedings – Mathematical Sciences; Volume 115; Issue 4. Commutators of Integral Operators with Variable Kernels on Hardy Spaces. Pu Zhang Kai Zhao. Volume 115 Issue 4 November 2005 pp 399-410 ... Keywords. Singular and fractional integrals; variable kernel; commutator; Hardy space.

Predicted stand volume for Eucalyptus plantations by spatial analysis

Science.gov (United States)

Latifah, Siti; Teodoro, RV; Myrna, GC; Nathaniel, CB; Leonardo, M. F.

2018-03-01

The main objective of the present study was to assess nonlinear models generated by integrating the stand volume growth rate to estimate the growth and yield of Eucalyptus. The primary data was done for point of interest (POI) of permanent sample plots (PSPs) and inventory sample plots, in Aek Nauli sector, Simalungun regency,North Sumatera Province,Indonesia. from December 2008- March 2009. Today,the demand for forestry information has continued to grow over recent years. Because many forest managers and decision makers face complex decisions, reliable information has become the necessity. In the assessment of natural resources including plantation forests have been widely used geospatial technology.The yield of Eucalyptus plantations represented by merchantable volume as dependent variable while factors affecting yield namely stands variables and the geographic variables as independent variables. The majority of the areas in the study site has stand volume class 0 - 50 m3/ha with 16.59 ha or 65.85 % of the total study site.

Microstructure-Aided Digital Volume Correlation

Directory of Open Access Journals (Sweden)

Hild F.

2010-06-01

Full Text Available This paper describes how volumic images of a composite material could be used to measure 3D displacement fields, and assess mechanical properties. The exemple of a tensile test performed on a sample made of an energetic material is chosen. Different tools are used, namely, X-ray microtomography of an in situ experiment, image acquisition and processing, volume correlation to measure 3D displacement fields. The principle of an integrated approach is finally introduced.

Trans-Caspian gas pipeline feasibility study. Volume 2

International Nuclear Information System (INIS)

1999-01-01

This study, conducted by Enron Engineering and Construction Company, was funded by the US Trade and Development Agency. The study provides detailed information concerning natural gas demand in Turkey and Southern Europe. The purpose of the study is to estimate the rate at which new gas can be absorbed in the Turkish market and be re-exported to the markets in Europe, as well as to forecast Turkish natural gas demand for the period up to 2020. The study also evaluates gas demand and pricing for the market in the 2002--2005 time frame. This is Volume 2 of a 3-volume report, and it is divided into the following sections: (1) Executive Summary; (2) Policy, Legal and Administrative Framework; (3) Assessment of Alternatives; (4) Baseline Conditions in the Project Area; (5) Potential (Unmitigated) Environment, Health and Safety Impacts; (6) Proposed Environmental Prevention and Mitigation; (7) Projected Net Environmental Impacts; (8) Bibliography

A longitudinal study of brain volume changes in normal aging

Energy Technology Data Exchange (ETDEWEB)

Takao, Hidemasa, E-mail: takaoh-tky@umin.ac.jp [Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan); Hayashi, Naoto [Department of Computational Diagnostic Radiology and Preventive Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan); Ohtomo, Kuni [Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan)

2012-10-15

Purpose: To evaluate the effect of normal aging on brain volumes and examine the effects of age and sex on the rates of changes in global and regional brain volumes. Methods: A total of 199 normal subjects (65 females and 134 males, mean age = 56.4 ± 9.9 years, age range = 38.1–82.9 years) were included in this study. Each subject was scanned twice, at an interval of about 2 years (range = 1.5–2.3 years). Two-time-point percentage brain volume change (PBVC) was estimated with SIENA 2.6. Results: The mean annualized PBVC was −0.23%/y. Analysis of covariance (ANCOVA) for annual brain volume changes revealed a main effect of age. There was no main effect of sex, nor was there a sex-by-age interaction. Voxel-wise analysis revealed a negative correlation between age and edge displacement values mainly in the periventricular region. Conclusions: The results of our study indicate that brain atrophy accelerates with increasing age and that there is no gender difference in the rate of brain atrophy.

A longitudinal study of brain volume changes in normal aging

International Nuclear Information System (INIS)

Takao, Hidemasa; Hayashi, Naoto; Ohtomo, Kuni

2012-01-01

Purpose: To evaluate the effect of normal aging on brain volumes and examine the effects of age and sex on the rates of changes in global and regional brain volumes. Methods: A total of 199 normal subjects (65 females and 134 males, mean age = 56.4 ± 9.9 years, age range = 38.1–82.9 years) were included in this study. Each subject was scanned twice, at an interval of about 2 years (range = 1.5–2.3 years). Two-time-point percentage brain volume change (PBVC) was estimated with SIENA 2.6. Results: The mean annualized PBVC was −0.23%/y. Analysis of covariance (ANCOVA) for annual brain volume changes revealed a main effect of age. There was no main effect of sex, nor was there a sex-by-age interaction. Voxel-wise analysis revealed a negative correlation between age and edge displacement values mainly in the periventricular region. Conclusions: The results of our study indicate that brain atrophy accelerates with increasing age and that there is no gender difference in the rate of brain atrophy

Defect forces, defect couples and path integrals in fracture mechanics

International Nuclear Information System (INIS)

Roche, R.L.

1979-07-01

In this work, it is shown that the path integrals can be introduced without any reference to the material behavior. The method is based on the definition in a continuous medium of a set of vectors and couples having the dimension of a force or a moment. More precisely, definitions are given of volume defect forces, surface defect forces, volume defect couples, and surface defect couples. This is done with the help of the stress working variation of a particule moving through the solid. The most important result is: the resultant of all the defect forces included in a volume V is the J integral on the surface surrounding V and the moment resultant is the L integral. So these integrals are defined without any assumption on the material constitutive equation. Another result is the material form of the virtual work principle - defect forces are acting like conventional forces in the conventional principles of virtual work. This lead to the introduction of the energy momentum tensor and of the associated couple stress. Application of this method is made to fracture mechanics in studying the defect forces distribution around a crack [fr

Studies of left ventricular volume estimation from single photon emission computed tomography

International Nuclear Information System (INIS)

Hiraki, Yoshio; Shimizu, Mitsuharu; Joja, Ikuo; Aono, Kaname; Yanagi, Hidekiyo; Indo, Haruaki; Seno, Yoshimasa; Teramoto, Shigeru; Nagaya, Isao.

1988-01-01

We studied the comparative accuracy of 99m Tc cardiac blood pool Single Photon Emission Computed Tomography (SPECT) for the measurement of left ventricular volume in 20 patients undergoing SPECT and single plane contrast left ventriculography (LVG). Left ventricular volume was calculated based on the total number of voxels in left ventricle. End-diastolic left ventricular volume (EDV) and end-systolic left ventricular volume (ESV) calculated from SPECT were compared with those from LVG. SPECT volume values showed a high degree of correlation with those by LVG (r = 0.923 for EDV, r = 0.903 for ESV). We appreciated the usefulness and accuracy of SPECT in measuring left ventricular volume because of its three-dimensional information. (author)

Integrated Food studies education and research:

DEFF Research Database (Denmark)

Hansen, Mette Weinreich; Hansen, Stine Rosenlund

2018-01-01

The research group Foodscapes Innovation and Networks has addressed integrated food studies issues in re-search and education since 2010. Based on experiences in the group, this paper aims at discussing the chal-lenges, learning outcomes and potentials for pushing an integrated thinking into rese......The research group Foodscapes Innovation and Networks has addressed integrated food studies issues in re-search and education since 2010. Based on experiences in the group, this paper aims at discussing the chal-lenges, learning outcomes and potentials for pushing an integrated thinking...... into research and education. It also addresses the challenges in integration when the methodological approaches and theoretical frameworks chosen are ontologically and epistemologically different. A discussion of the limitations of integration is thus also part of the paper. The conceptual framework...... of ontonorms (Mol, 2013) is suggested as a common point of departure for a further development of integration. This is suggested relevant due to the fact that it forces different traditions to reflect their own value-related basis and discuss implications of this approach in a broader sense. The common values...

A prospective study of corpus callosum regional volumes and neurocognitive outcomes following cranial radiation for pediatric brain tumors.

Science.gov (United States)

Rashid, Arif; Ram, Ashwin N; Kates, Wendy R; Redmond, Kristin J; Wharam, Moody; Mark Mahone, E; Horska, Alena; Terezakis, Stephanie

2017-06-01

Cranial radiation therapy (CRT) may disrupt the corpus callosum (CC), which plays an important role in basic motor and cognitive functions. The aim of this prospective longitudinal study was to assess changes in CC mid-sagittal areas, CC volumes, and performance on neuropsychological (NP) tests related to the CC in children following CRT. Twelve pediatric patients were treated with CRT for primary brain malignancies. Thirteen age-matched healthy volunteers served as controls. Brain MRIs and NP assessment emphasizing motor dexterity, processing speed, visuomotor integration, and working memory (visual and verbal) were performed at baseline and at 6, 15, and 27 months following completion of CRT. Linear mixed effects (LME) analyses were used to evaluate patient NP performance and changes in regional CC volumes (genu, anterior body, mid-body, posterior body, and splenium) and mid-sagittal areas over time and with radiation doses, correcting for age at CRT start. The mean age at CRT was 9.41 (range 1.2-15.7) years. The median prescription dose was 54 (range 18-59.4) Gy. LME analysis revealed a significant decrease in overall CC volumes over time (p memory (both p memory. Further prospective study of larger cohorts of patients is needed to establish the relationship between CRT dose, neuroanatomical, and functional changes in the CC.

Adrenal gland volume measurement in septic shock and control patients: a pilot study

Energy Technology Data Exchange (ETDEWEB)

Nougaret, Stephanie; Aufort, S.; Gallix, B. [Hopital Saint Eloi, Department of Abdominal Imaging, CHU Montpellier, Montpellier, Cedex 5 (France); Jung, B.; Chanques, G.; Jaber, S. [Hopital Saint Eloi, Intensive Care Unit, Department of Critical Care and Anesthesiology: DAR B, CHU Montpellier, Montpellier, Cedex 5 (France)

2010-10-15

To compare adrenal gland volume in septic shock patients and control patients by using semi-automated volumetry. Adrenal gland volume and its inter-observer variability were measured with tomodensitometry using semi-automated software in 104 septic shock patients and in 40 control patients. The volumes of control and septic shock patients were compared and the relationship between volume and outcome in intensive care was studied. The mean total volume of both adrenal glands was 7.2 {+-} 2.0 cm{sup 3} in control subjects and 13.3 {+-} 4.7 cm{sup 3} for total adrenal gland volume in septic shock patients (p < 0.0001). Measurement reproducibility was excellent with a concordance correlation coefficient value of 0.87. The increasing adrenal gland volume was associated with a higher rate of survival in intensive care. The present study reports that with semi-automated software, adrenal gland volume can be measured easily and reproducibly. Adrenal gland volume was found to be nearly double in sepsis compared with control patients. The absence of increased volume during sepsis would appear to be associated with a higher rate of mortality and may represent a prognosis factor which may help the clinician to guide their strategy. (orig.)

Adrenal gland volume measurement in septic shock and control patients: a pilot study

International Nuclear Information System (INIS)

Nougaret, Stephanie; Aufort, S.; Gallix, B.; Jung, B.; Chanques, G.; Jaber, S.

2010-01-01

To compare adrenal gland volume in septic shock patients and control patients by using semi-automated volumetry. Adrenal gland volume and its inter-observer variability were measured with tomodensitometry using semi-automated software in 104 septic shock patients and in 40 control patients. The volumes of control and septic shock patients were compared and the relationship between volume and outcome in intensive care was studied. The mean total volume of both adrenal glands was 7.2 ± 2.0 cm 3 in control subjects and 13.3 ± 4.7 cm 3 for total adrenal gland volume in septic shock patients (p < 0.0001). Measurement reproducibility was excellent with a concordance correlation coefficient value of 0.87. The increasing adrenal gland volume was associated with a higher rate of survival in intensive care. The present study reports that with semi-automated software, adrenal gland volume can be measured easily and reproducibly. Adrenal gland volume was found to be nearly double in sepsis compared with control patients. The absence of increased volume during sepsis would appear to be associated with a higher rate of mortality and may represent a prognosis factor which may help the clinician to guide their strategy. (orig.)

Change in brain and lesion volumes after CEE therapies: the WHIMS-MRI studies.

Science.gov (United States)

Coker, Laura H; Espeland, Mark A; Hogan, Patricia E; Resnick, Susan M; Bryan, R Nick; Robinson, Jennifer G; Goveas, Joseph S; Davatzikos, Christos; Kuller, Lewis H; Williamson, Jeff D; Bushnell, Cheryl D; Shumaker, Sally A

2014-02-04

To determine whether smaller brain volumes in older women who had completed Women's Health Initiative (WHI)-assigned conjugated equine estrogen-based hormone therapy (HT), reported by WHI Memory Study (WHIMS)-MRI, correspond to a continuing increased rate of atrophy an average of 6.1 to 7.7 years later in WHIMS-MRI2. A total of 1,230 WHI participants were contacted: 797 (64.8%) consented, and 729 (59%) were rescanned an average of 4.7 years after the initial MRI scan. Mean annual rates of change in total brain volume, the primary outcome, and rates of change in ischemic lesion volumes, the secondary outcome, were compared between treatment groups using mixed-effect models with adjustment for trial, clinical site, age, intracranial volumes, and time between MRI measures. Total brain volume decreased an average of 3.22 cm(3)/y in the active arm and 3.07 cm(3)/y in the placebo arm (p = 0.53). Total ischemic lesion volumes increased in both arms at a rate of 0.12 cm(3)/y (p = 0.88). Conjugated equine estrogen-based postmenopausal HT, previously assigned at WHI baseline, did not affect rates of decline in brain volumes or increases in brain lesion volumes during the 4.7 years between the initial and follow-up WHIMS-MRI studies. Smaller frontal lobe volumes were observed as persistent group differences among women assigned to active HT compared with placebo. Women with a history of cardiovascular disease treated with active HT, compared with placebo, had higher rates of accumulation in white matter lesion volume and total brain lesion volume. Further study may elucidate mechanisms that explain these findings.

Parsing partial molar volumes of small molecules: a molecular dynamics study.

Science.gov (United States)

Patel, Nisha; Dubins, David N; Pomès, Régis; Chalikian, Tigran V

2011-04-28

We used molecular dynamics (MD) simulations in conjunction with the Kirkwood-Buff theory to compute the partial molar volumes for a number of small solutes of various chemical natures. We repeated our computations using modified pair potentials, first, in the absence of the Coulombic term and, second, in the absence of the Coulombic and the attractive Lennard-Jones terms. Comparison of our results with experimental data and the volumetric results of Monte Carlo simulation with hard sphere potentials and scaled particle theory-based computations led us to conclude that, for small solutes, the partial molar volume computed with the Lennard-Jones potential in the absence of the Coulombic term nearly coincides with the cavity volume. On the other hand, MD simulations carried out with the pair interaction potentials containing only the repulsive Lennard-Jones term produce unrealistically large partial molar volumes of solutes that are close to their excluded volumes. Our simulation results are in good agreement with the reported schemes for parsing partial molar volume data on small solutes. In particular, our determined interaction volumes() and the thickness of the thermal volume for individual compounds are in good agreement with empirical estimates. This work is the first computational study that supports and lends credence to the practical algorithms of parsing partial molar volume data that are currently in use for molecular interpretations of volumetric data.

HiRel: Hybrid Automated Reliability Predictor (HARP) integrated reliability tool system, (version 7.0). Volume 1: HARP introduction and user's guide

Science.gov (United States)

Bavuso, Salvatore J.; Rothmann, Elizabeth; Dugan, Joanne Bechta; Trivedi, Kishor S.; Mittal, Nitin; Boyd, Mark A.; Geist, Robert M.; Smotherman, Mark D.

1994-01-01

The Hybrid Automated Reliability Predictor (HARP) integrated Reliability (HiRel) tool system for reliability/availability prediction offers a toolbox of integrated reliability/availability programs that can be used to customize the user's application in a workstation or nonworkstation environment. HiRel consists of interactive graphical input/output programs and four reliability/availability modeling engines that provide analytical and simulative solutions to a wide host of reliable fault-tolerant system architectures and is also applicable to electronic systems in general. The tool system was designed to be compatible with most computing platforms and operating systems, and some programs have been beta tested, within the aerospace community for over 8 years. Volume 1 provides an introduction to the HARP program. Comprehensive information on HARP mathematical models can be found in the references.

Space Flight Human System Standards (SFHSS). Volume 2; Human Factors, Habitability and Environmental Factors" and Human Integration Design Handbook (HIDH)

Science.gov (United States)

Davis, Jeffrey R.; Fitts, David J.

2009-01-01

This viewgraph presentation reviews the standards for space flight hardware based on human capabilities and limitations. The contents include: 1) Scope; 2) Applicable documents; 3) General; 4) Human Physical Characteristics and Capabilities; 5) Human Performance and Cognition; 6) Natural and Induced Environments; 7) Habitability Functions; 8) Architecture; 9) Hardware and Equipment; 10) Crew Interfaces; 11) Spacesuits; 12) Operatons: Reserved; 13) Ground Maintenance and Assembly: Reserved; 14) Appendix A-Reference Documents; 15) Appendix N-Acronyms and 16) Appendix C-Definition. Volume 2 is supported by the Human Integration Design Handbook (HIDH)s.

Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI Study.

Science.gov (United States)

Resnick, S M; Espeland, M A; Jaramillo, S A; Hirsch, C; Stefanick, M L; Murray, A M; Ockene, J; Davatzikos, C

2009-01-13

To determine whether menopausal hormone therapy (HT) affects regional brain volumes, including hippocampal and frontal regions. Brain MRI scans were obtained in a subset of 1,403 women aged 71-89 years who participated in the Women's Health Initiative Memory Study (WHIMS). WHIMS was an ancillary study to the Women's Health Initiative, which consisted of two randomized, placebo-controlled trials: 0.625 mg conjugated equine estrogens (CEE) with or without 2.5 mg medroxyprogesterone acetate (MPA) in one daily tablet. Scans were performed, on average, 3.0 years post-trial for the CEE + MPA trial and 1.4 years post-trial for the CEE-Alone trial; average on-trial follow-up intervals were 4.0 years for CEE + MPA and 5.6 years for CEE-Alone. Total brain, ventricular, hippocampal, and frontal lobe volumes, adjusted for age, clinic site, estimated intracranial volume, and dementia risk factors, were the main outcome variables. Compared with placebo, covariate-adjusted mean frontal lobe volume was 2.37 cm(3) lower among women assigned to HT (p = 0.004), mean hippocampal volume was slightly (0.10 cm(3)) lower (p = 0.05), and differences in total brain volume approached significance (p = 0.07). Results were similar for CEE + MPA and CEE-Alone. HT-associated reductions in hippocampal volumes were greatest in women with the lowest baseline Modified Mini-Mental State Examination scores (scores equine estrogens with or without MPA are associated with greater brain atrophy among women aged 65 years and older; however, the adverse effects are most evident in women experiencing cognitive deficits before initiating hormone therapy.

Lung volumes: measurement, clinical use, and coding.

Science.gov (United States)

Flesch, Judd D; Dine, C Jessica

2012-08-01

Measurement of lung volumes is an integral part of complete pulmonary function testing. Some lung volumes can be measured during spirometry; however, measurement of the residual volume (RV), functional residual capacity (FRC), and total lung capacity (TLC) requires special techniques. FRC is typically measured by one of three methods. Body plethysmography uses Boyle's Law to determine lung volumes, whereas inert gas dilution and nitrogen washout use dilution properties of gases. After determination of FRC, expiratory reserve volume and inspiratory vital capacity are measured, which allows the calculation of the RV and TLC. Lung volumes are commonly used for the diagnosis of restriction. In obstructive lung disease, they are used to assess for hyperinflation. Changes in lung volumes can also be seen in a number of other clinical conditions. Reimbursement for measurement of lung volumes requires knowledge of current procedural terminology (CPT) codes, relevant indications, and an appropriate level of physician supervision. Because of recent efforts to eliminate payment inefficiencies, the 10 previous CPT codes for lung volumes, airway resistance, and diffusing capacity have been bundled into four new CPT codes.

Surgical volume and conversion rate in laparoscopic hysterectomy: does volume matter? A multicenter retrospective cohort study.

Science.gov (United States)

Keurentjes, José H M; Briët, Justine M; de Bock, Geertruida H; Mourits, Marian J E

2018-02-01

A multicenter, retrospective, cohort study was conducted in the Netherlands. The aim was to evaluate whether surgical volume of laparoscopic hysterectomies (LHs) performed by proven skilled gynecologists had an impact on the conversion rate from laparoscopy to laparotomy. In 14 hospitals, all LHs performed by 19 proven skilled gynecologists between 2007 and 2010 were included in the analysis. Surgical volume, conversion rate and type of conversion (reactive or strategic) were retrospectively assessed. To estimate the impact of surgical volume on the conversion rate, logistic regressions were performed. These regressions were adjusted for patient's age, Body Mass Index (BMI), ASA classification, previous abdominal surgery and the indication (malignant versus benign) for the LH. During the study period, 19 proven skilled gynecologists performed a total of 1051 LHs. Forty percent of the gynecologists performed over 20 LHs per year (median 17.3, range 5.4-49.5). Conversion to laparotomy occurred in 5.0% of all LHs (53 of 1051); 38 (3.6%) were strategic and 15 (1.4%) were reactive conversions. Performing over 20 LHs per year was significantly associated with a lower overall conversion rate (OR adjusted 0.43, 95% CI 0.24-0.77), a lower strategic conversion rate (OR adjusted 0.32, 95% CI 0.16-0.65), but not with a lower reactive conversion rate (OR adjusted 0.96, 95% CI 0.33-2.79). A higher annual surgical volume of LHs by proven skilled gynecologists is inversely related to the conversion rate to laparotomy, and results in a lower strategic conversion rate.

Exploring Dutch surgeons' views on volume-based policies: a qualitative interview study.

Science.gov (United States)

Mesman, Roos; Faber, Marjan J; Westert, Gert P; Berden, Bart

2018-01-01

Objective In many countries, the evidence for volume-outcome associations in surgery has been transferred into policy. Despite the large body of research that exists on the topic, qualitative studies aimed at surgeons' views on, and experiences with, these volume-based policies are lacking. We interviewed Dutch surgeons to gain more insight into the implications of volume-outcome policies for daily clinical practice, as input for effective surgical quality improvement. Methods Semi-structured interviews were conducted with 20 purposively selected surgeons from a stratified sample for hospital type and speciality. The interviews were recorded, transcribed verbatim and underwent inductive content analysis. Results Two overarching themes were inductively derived from the data: (1) minimum volume standards and (2) implications of volume-based policies. Although surgeons acknowledged the premise 'more is better', they were critical about the validity and underlying evidence for minimum volume standards. Patients often inquire about caseload, which is met with both understanding and discomfort. Surgeons offered many examples of controversies surrounding the process of determining thresholds as well as the ways in which health insurers use volume as a purchasing criterion. Furthermore, being held accountable for caseload may trigger undesired strategic behaviour, such as unwarranted operations. Volume-based policies also have implications for the survival of low-volume providers and affect patient travel times, although the latter is not necessarily problematic in the Dutch context. Conclusions Surgeons in this study acknowledged that more volume leads to better quality. However, validity issues, undesired strategic behaviour and the ways in which minimum volume standards are established and applied have made surgeons critical of current policy practice. These findings suggest that volume remains a controversial quality measure and causes polarization that is not

Changes in atheroma volume estimated from digitized femoral arteriograms

International Nuclear Information System (INIS)

Nilsson, S.; Erikson, U.

1990-01-01

To evaluate the effects of treatment in patients with cardiovascular risk factors, valid and reproducible methods for assessing changes in atheroma volume are required. We postulated that these changes could be accurately estimated by repeat measurement of the lumen volume of the artery to be studied. With a computer-based technique, the lumen volume of a 20 cm segment of the femoral artery was measured in arteriograms from 107 patients with hypercholesterolemia. Films were digitized with use of a high-resolution scanner, cross-sectional areas were calculated with a slice thickness of 150 μm and the lumen volume was obtained by their integration. The validity of the method was demonstrated in model experiments. An automatic algorithm to correct for changes due to patient positioning was developed and validated in a model experiment. With repeat measurment 10 min and 11 to 13 months apart the coefficients of variation were 2.9% (N=107) and 6.1% (N=29), respectively. (orig.)

A Note on the First Integrals of Vector Fields with Integrating Factors and Normalizers

Directory of Open Access Journals (Sweden)

Jaume Llibre

2012-06-01

Full Text Available We prove a sufficient condition for the existence of explicit first integrals for vector fields which admit an integrating factor. This theorem recovers and extends previous results in the literature on the integrability of vector fields which are volume preserving and possess nontrivial normalizers. Our approach is geometric and coordinate-free and hence it works on any smooth orientable manifold.

Study of the Utah uranium-milling industry. Volume I. A policy analysis

International Nuclear Information System (INIS)

Turley, R.E.

1980-05-01

This is the first volume of a two volume study of the Utah Uranium Milling Industry. The study was precipitated by a 1977 report issued by the Western Interstate Nuclear Board entitled Policy Recommendations on Financing Stabilization. Perpetual Surveillance and Maintenance of Uranium Mill Tailings. Volume I of this study is a policy analysis or technology assessment of the uranium milling industry in the state of Utah; specifically, the study addresses issues that deal with the perpetual surveillance, monitoring, and maintenance of uranium tailings piles at the end of uranium milling operations, i.e., following shutdown and decommissioning. Volume II of this report serves somewhat as an appendix. It represents a full description of the uranium industry in the state of Utah, including its history and statements regarding its future. The topics covered in volume I are as follows: today's uranium industry in Utah; management of the industry's characteristic nuclear radiation; uranium mill licensing and regulation; state licensing and regulation of uranium mills; forecast of future milling operations; policy needs relative to perpetual surveillance, monitoring, and maintenance of tailings; policy needs relative to perpetual oversight; economic aspects; state revenue from uranium; and summary with conclusions and recommendations. Appendices, figures and tables are also presented

Are PCI Service Volumes Associated with 30-Day Mortality? A Population-Based Study from Taiwan.

Science.gov (United States)

Yu, Tsung-Hsien; Chou, Ying-Yi; Wei, Chung-Jen; Tung, Yu-Chi

2017-11-09

The volume-outcome relationship has been discussed for over 30 years; however, the findings are inconsistent. This might be due to the heterogeneity of service volume definitions and categorization methods. This study takes percutaneous coronary intervention (PCI) as an example to examine whether the service volume was associated with PCI 30-day mortality, given different service volume definitions and categorization methods. A population-based, cross-sectional multilevel study was conducted. Two definitions of physician and hospital volume were used: (1) the cumulative PCI volume in a previous year before each PCI; (2) the cumulative PCI volume within the study period. The volume was further treated in three ways: (1) a categorical variable based on the American Heart Association's recommendation; (2) a semi-data-driven categorical variable based on k-means clustering algorithm; and (3) a data-driven categorical variable based on the Generalized Additive Model. The results showed that, after adjusting the patient-, physician-, and hospital-level covariates, physician volume was associated inversely with PCI 30-day mortality, but hospital volume was not, no matter which definitions and categorization methods of service volume were applied. Physician volume is negatively associated with PCI 30-day mortality, but the results might vary because of definition and categorization method.

[Target volume margins for lung cancer: internal target volume/clinical target volume].

Science.gov (United States)

Jouin, A; Pourel, N

2013-10-01

The aim of this study was to carry out a review of margins that should be used for the delineation of target volumes in lung cancer, with a focus on margins from gross tumour volume (GTV) to clinical target volume (CTV) and internal target volume (ITV) delineation. Our review was based on a PubMed literature search with, as a cornerstone, the 2010 European Organisation for Research and Treatment of Cancer (EORTC) recommandations by De Ruysscher et al. The keywords used for the search were: radiotherapy, lung cancer, clinical target volume, internal target volume. The relevant information was categorized under the following headings: gross tumour volume definition (GTV), CTV-GTV margin (first tumoural CTV then nodal CTV definition), in field versus elective nodal irradiation, metabolic imaging role through the input of the PET scanner for tumour target volume and limitations of PET-CT imaging for nodal target volume definition, postoperative radiotherapy target volume definition, delineation of target volumes after induction chemotherapy; then the internal target volume is specified as well as tumoural mobility for lung cancer and respiratory gating techniques. Finally, a chapter is dedicated to planning target volume definition and another to small cell lung cancer. For each heading, the most relevant and recent clinical trials and publications are mentioned. Copyright © 2013. Published by Elsevier SAS.

Dose-volume considerations in stereotaxic brain radiation therapy

International Nuclear Information System (INIS)

Houdek, P.V.; Schwade, J.G.; Pisciotta, V.J.; Medina, A.J.; Lewin, A.A.; Abitbol, A.A.; Serago, C.F.

1988-01-01

Although brain radiation therapy experience suggests that a gain in the therapeutic ratio may be achieved by optimizing the dose-volume relationship, no practical system for quantitative assessment of dose-volume data has been developed. This presentation describes the rationale for using the integral dose function for this purpose and demonstrates that with the use of a conventional treatment planning computer and a series of computed tomographic scans, first-order optimization of the dose-volume function can be accomplished in two steps: first, high-dose volume is minimized by selecting an appropriate treatment technique and tumor margin, and then dosage is maximized by calculating the brain tolerance dose as a function of the irradiated volume

Integral and discrete inequalities and their applications

CERN Document Server

Qin, Yuming

2016-01-01

This book focuses on one- and multi-dimensional linear integral and discrete Gronwall-Bellman type inequalities. It provides a useful collection and systematic presentation of known and new results, as well as many applications to differential (ODE and PDE), difference, and integral equations. With this work the author fills a gap in the literature on inequalities, offering an ideal source for researchers in these topics. The present volume is part 1 of the author’s two-volume work on inequalities. Integral and discrete inequalities are a very important tool in classical analysis and play a crucial role in establishing the well-posedness of the related equations, i.e., differential, difference and integral equations.

Critical Propulsion Components. Volume 1; Summary, Introduction, and Propulsion Systems Studies

Science.gov (United States)

2005-01-01

Several studies have concluded that a supersonic aircraft, if environmentally acceptable and economically viable, could successfully compete in the 21st century marketplace. However, before industry can commit to what is estimated as a 15 to 20 billion dollar investment, several barrier issues must be resolved. In an effort to address these barrier issues, NASA and Industry teamed to form the High-Speed Research (HSR) program. As part of this program, the Critical Propulsion Components (CPC) element was created and assigned the task of developing those propulsion component technologies necessary to: (1) reduce cruise emissions by a factor of 10 and (2) meet the ever-increasing airport noise restrictions with an economically viable propulsion system. The CPC-identified critical components were ultra-low emission combustors, low-noise/high-performance exhaust nozzles, low-noise fans, and stable/high-performance inlets. Propulsion cycle studies (coordinated with NASA Langley Research Center sponsored airplane studies) were conducted throughout this CPC program to help evaluate candidate components and select the best concepts for the more complex and larger scale research efforts. The propulsion cycle and components ultimately selected were a mixed-flow turbofan (MFTF) engine employing a lean, premixed, prevaporized (LPP) combustor coupled to a two-dimensional mixed compression inlet and a two-dimensional mixer/ejector nozzle. Due to the large amount of material presented in this report, it was prepared in four volumes; Volume 1: Summary, Introduction, and Propulsion System Studies, Volume 2: Combustor, Volume 3: Exhaust Nozzle, and Volume 4: Inlet and Fan/ Inlet Acoustic Team.

Identifying Structure-Property Relationships Through DREAM.3D Representative Volume Elements and DAMASK Crystal Plasticity Simulations: An Integrated Computational Materials Engineering Approach

Science.gov (United States)

Diehl, Martin; Groeber, Michael; Haase, Christian; Molodov, Dmitri A.; Roters, Franz; Raabe, Dierk

2017-05-01

Predicting, understanding, and controlling the mechanical behavior is the most important task when designing structural materials. Modern alloy systems—in which multiple deformation mechanisms, phases, and defects are introduced to overcome the inverse strength-ductility relationship—give raise to multiple possibilities for modifying the deformation behavior, rendering traditional, exclusively experimentally-based alloy development workflows inappropriate. For fast and efficient alloy design, it is therefore desirable to predict the mechanical performance of candidate alloys by simulation studies to replace time- and resource-consuming mechanical tests. Simulation tools suitable for this task need to correctly predict the mechanical behavior in dependence of alloy composition, microstructure, texture, phase fractions, and processing history. Here, an integrated computational materials engineering approach based on the open source software packages DREAM.3D and DAMASK (Düsseldorf Advanced Materials Simulation Kit) that enables such virtual material development is presented. More specific, our approach consists of the following three steps: (1) acquire statistical quantities that describe a microstructure, (2) build a representative volume element based on these quantities employing DREAM.3D, and (3) evaluate the representative volume using a predictive crystal plasticity material model provided by DAMASK. Exemplarily, these steps are here conducted for a high-manganese steel.

Integration of borehole and seismic data to unravel complex stratigraphy: Case studies from the Mannville Group, Western Canada

Science.gov (United States)

Sarzalejo Silva, Sabrina Ester

Understanding the stratigraphic architecture of geologically complex reservoirs, such as the heavy oil deposits of Western Canada, is essential to achieve an efficient hydrocarbon recovery. Borehole and 3-D seismic data were integrated to define the stratigraphic architecture and generate 3-dimensional geological models of the Mannville Group in Saskatchewan. The Mannville is a stratigraphically complex unit formed of fluvial to marine deposits. Two areas in west-central and southern Saskatchewan were examined in this study. In west-central Saskatchewan, the area corresponds to a stratigraphically controlled heavy oil reservoir with production from the undifferentiated Dina-Cummings Members of the Lower Cretaceous Mannville Group. The southern area, although non-prospective for hydrocarbons, shares many similarities with time-equivalent strata in areas of heavy oil production. Seismic sequence stratigraphic principles together with log signatures permitted the subdivision of the Mannville into different packages. An initial geological model was generated integrating seismic and well-log data Multiattribute analysis and neural networks were used to generate a pseudo-lithology or gamma-ray volume. The incorporation of borehole core data to the model and the subsequent integration with the lithological prediction were crucial to capture the distribution of reservoir and non-reservoir deposits in the study area. The ability to visualize the 3-D seismic data in a variety of ways, including arbitrary lines and stratal or horizon slicing techniques helped the definition of stratigraphic features such as channels and scroll bars that affect fluid flow in hydrocarbon producing areas. Small-scale heterogeneities in the reservoir were not resolved due to the resolution of the seismic data. Although not undertaken in this study, the resulting stratigraphic framework could be used to help construct a static reservoir model. Because of the small size of the 3-D seismic surveys

Delayed recall, hippocampal volume and Alzheimer neuropathology: findings from the Nun Study.

Science.gov (United States)

Mortimer, J A; Gosche, K M; Riley, K P; Markesbery, W R; Snowdon, D A

2004-02-10

To examine the associations of hippocampal volume and the severity of neurofibrillary lesions determined at autopsy with delayed verbal recall performance evaluated an average of 1 year prior to death. Hippocampal volumes were computed using postmortem brain MRI from the first 56 scanned participants of the Nun Study. Quantitative neuropathologic studies included lesion counts, Braak staging, and determination of whether neuropathologic criteria for Alzheimer disease (AD) were met. Multiple regression was used to assess the association of hippocampal volume and neuropathologic lesions with the number of words (out of 10) recalled on the Consortium to Establish a Registry for Alzheimer's Disease Delayed Word Recall Test administered an average of 1 year prior to death. When entered separately, hippocampal volume, Braak stage, and the mean neurofibrillary tangle counts in the CA-1 region of the hippocampus and the subiculum were strongly associated with the number of words recalled after a delay, adjusting for age and education. When hippocampal volume was entered together with each neuropathologic index, only hippocampal volume retained a significant association with the delayed recall measure. The association between hippocampal volume and the number of words recalled was present in both demented and nondemented individuals as well as in those with and without substantial AD neurofibrillary pathology. The association of neurofibrillary tangles with delayed verbal recall may reflect associated hippocampal atrophy.

Forecasting daily patient volumes in the emergency department.

Science.gov (United States)

Jones, Spencer S; Thomas, Alun; Evans, R Scott; Welch, Shari J; Haug, Peter J; Snow, Gregory L

2008-02-01

Shifts in the supply of and demand for emergency department (ED) resources make the efficient allocation of ED resources increasingly important. Forecasting is a vital activity that guides decision-making in many areas of economic, industrial, and scientific planning, but has gained little traction in the health care industry. There are few studies that explore the use of forecasting methods to predict patient volumes in the ED. The goals of this study are to explore and evaluate the use of several statistical forecasting methods to predict daily ED patient volumes at three diverse hospital EDs and to compare the accuracy of these methods to the accuracy of a previously proposed forecasting method. Daily patient arrivals at three hospital EDs were collected for the period January 1, 2005, through March 31, 2007. The authors evaluated the use of seasonal autoregressive integrated moving average, time series regression, exponential smoothing, and artificial neural network models to forecast daily patient volumes at each facility. Forecasts were made for horizons ranging from 1 to 30 days in advance. The forecast accuracy achieved by the various forecasting methods was compared to the forecast accuracy achieved when using a benchmark forecasting method already available in the emergency medicine literature. All time series methods considered in this analysis provided improved in-sample model goodness of fit. However, post-sample analysis revealed that time series regression models that augment linear regression models by accounting for serial autocorrelation offered only small improvements in terms of post-sample forecast accuracy, relative to multiple linear regression models, while seasonal autoregressive integrated moving average, exponential smoothing, and artificial neural network forecasting models did not provide consistently accurate forecasts of daily ED volumes. This study confirms the widely held belief that daily demand for ED services is characterized by

MRI-assisted PET motion correction for neurologic studies in an integrated MR-PET scanner.

Science.gov (United States)

Catana, Ciprian; Benner, Thomas; van der Kouwe, Andre; Byars, Larry; Hamm, Michael; Chonde, Daniel B; Michel, Christian J; El Fakhri, Georges; Schmand, Matthias; Sorensen, A Gregory

2011-01-01

Head motion is difficult to avoid in long PET studies, degrading the image quality and offsetting the benefit of using a high-resolution scanner. As a potential solution in an integrated MR-PET scanner, the simultaneously acquired MRI data can be used for motion tracking. In this work, a novel algorithm for data processing and rigid-body motion correction (MC) for the MRI-compatible BrainPET prototype scanner is described, and proof-of-principle phantom and human studies are presented. To account for motion, the PET prompt and random coincidences and sensitivity data for postnormalization were processed in the line-of-response (LOR) space according to the MRI-derived motion estimates. The processing time on the standard BrainPET workstation is approximately 16 s for each motion estimate. After rebinning in the sinogram space, the motion corrected data were summed, and the PET volume was reconstructed using the attenuation and scatter sinograms in the reference position. The accuracy of the MC algorithm was first tested using a Hoffman phantom. Next, human volunteer studies were performed, and motion estimates were obtained using 2 high-temporal-resolution MRI-based motion-tracking techniques. After accounting for the misalignment between the 2 scanners, perfectly coregistered MRI and PET volumes were reproducibly obtained. The MRI output gates inserted into the PET list-mode allow the temporal correlation of the 2 datasets within 0.2 ms. The Hoffman phantom volume reconstructed by processing the PET data in the LOR space was similar to the one obtained by processing the data using the standard methods and applying the MC in the image space, demonstrating the quantitative accuracy of the procedure. In human volunteer studies, motion estimates were obtained from echo planar imaging and cloverleaf navigator sequences every 3 s and 20 ms, respectively. Motion-deblurred PET images, with excellent delineation of specific brain structures, were obtained using these 2 MRI

MR-assisted PET Motion Correction for eurological Studies in an Integrated MR-PET Scanner

Science.gov (United States)

Catana, Ciprian; Benner, Thomas; van der Kouwe, Andre; Byars, Larry; Hamm, Michael; Chonde, Daniel B.; Michel, Christian J.; El Fakhri, Georges; Schmand, Matthias; Sorensen, A. Gregory

2011-01-01

Head motion is difficult to avoid in long PET studies, degrading the image quality and offsetting the benefit of using a high-resolution scanner. As a potential solution in an integrated MR-PET scanner, the simultaneously acquired MR data can be used for motion tracking. In this work, a novel data processing and rigid-body motion correction (MC) algorithm for the MR-compatible BrainPET prototype scanner is described and proof-of-principle phantom and human studies are presented. Methods To account for motion, the PET prompts and randoms coincidences as well as the sensitivity data are processed in the line or response (LOR) space according to the MR-derived motion estimates. After sinogram space rebinning, the corrected data are summed and the motion corrected PET volume is reconstructed from these sinograms and the attenuation and scatter sinograms in the reference position. The accuracy of the MC algorithm was first tested using a Hoffman phantom. Next, human volunteer studies were performed and motion estimates were obtained using two high temporal resolution MR-based motion tracking techniques. Results After accounting for the physical mismatch between the two scanners, perfectly co-registered MR and PET volumes are reproducibly obtained. The MR output gates inserted in to the PET list-mode allow the temporal correlation of the two data sets within 0.2 s. The Hoffman phantom volume reconstructed processing the PET data in the LOR space was similar to the one obtained processing the data using the standard methods and applying the MC in the image space, demonstrating the quantitative accuracy of the novel MC algorithm. In human volunteer studies, motion estimates were obtained from echo planar imaging and cloverleaf navigator sequences every 3 seconds and 20 ms, respectively. Substantially improved PET images with excellent delineation of specific brain structures were obtained after applying the MC using these MR-based estimates. Conclusion A novel MR-based MC

Analysis of electromagnetic wave interactions on nonlinear scatterers using time domain volume integral equations

KAUST Repository

Ulku, Huseyin Arda

2014-07-06

Effects of material nonlinearities on electromagnetic field interactions become dominant as field amplitudes increase. A typical example is observed in plasmonics, where highly localized fields “activate” Kerr nonlinearities. Naturally, time domain solvers are the method of choice when it comes simulating these nonlinear effects. Oftentimes, finite difference time domain (FDTD) method is used for this purpose. This is simply due to the fact that explicitness of the FDTD renders the implementation easier and the material nonlinearity can be easily accounted for using an auxiliary differential equation (J.H. Green and A. Taflove, Opt. Express, 14(18), 8305-8310, 2006). On the other hand, explicit marching on-in-time (MOT)-based time domain integral equation (TDIE) solvers have never been used for the same purpose even though they offer several advantages over FDTD (E. Michielssen, et al., ECCOMAS CFD, The Netherlands, Sep. 5-8, 2006). This is because explicit MOT solvers have never been stabilized until not so long ago. Recently an explicit but stable MOT scheme has been proposed for solving the time domain surface magnetic field integral equation (H.A. Ulku, et al., IEEE Trans. Antennas Propag., 61(8), 4120-4131, 2013) and later it has been extended for the time domain volume electric field integral equation (TDVEFIE) (S. B. Sayed, et al., Pr. Electromagn. Res. S., 378, Stockholm, 2013). This explicit MOT scheme uses predictor-corrector updates together with successive over relaxation during time marching to stabilize the solution even when time step is as large as in the implicit counterpart. In this work, an explicit MOT-TDVEFIE solver is proposed for analyzing electromagnetic wave interactions on scatterers exhibiting Kerr nonlinearity. Nonlinearity is accounted for using the constitutive relation between the electric field intensity and flux density. Then, this relation and the TDVEFIE are discretized together by expanding the intensity and flux - sing half

Leading with integrity: a qualitative research study.

Science.gov (United States)

Storr, Loma

2004-01-01

This research paper gives an account of a study into the relationship between leadership and integrity. There is a critical analysis of the current literature for effective, successful and ethical leadership particularly, integrity. The purpose and aim of this paper is to build on the current notions of leadership within the literature, debate contemporary approaches, focussing specifically on practices within the UK National Health Service in the early 21st century. This leads to a discussion of the literature on ethical leadership theory, which includes public service values, ethical relationships and leading with integrity. A small study was undertaken consisting of 18 interviews with leaders and managers within a District General HospitaL Using the Repertory Grid technique and analysis 15 themes emerged from the constructs elicited, which were compared to the literature for leadership and integrity and other studies. As well as finding areas of overlap, a number of additional constructs were elicited which suggested that effective leadership correlates with integrity and the presence of integrity will improve organisational effectiveness. The study identified that perceptions of leadership character and behaviour are used to judge the effectiveness and integrity of a leader. However, the ethical implications and consequences of leaders' scope of power and influence such as policy and strategy are somewhat neglected and lacking in debate. The findings suggest that leaders are not judged according to the ethical nature of decision making, and leading and managing complex change but that the importance of integrity and ethical leadership correlated with higher levels of hierarchical status and that it is assumed by virtue of status and success that leaders lead with integrity. Finally, the findings of this study seem to suggest that nurse leadership capability is developing as a consequence of recent national investment.

Problems in mathematical analysis III integration

CERN Document Server

Kaczor, W J

2003-01-01

We learn by doing. We learn mathematics by doing problems. This is the third volume of Problems in Mathematical Analysis. The topic here is integration for real functions of one real variable. The first chapter is devoted to the Riemann and the Riemann-Stieltjes integrals. Chapter 2 deals with Lebesgue measure and integration. The authors include some famous, and some not so famous, integral inequalities related to Riemann integration. Many of the problems for Lebesgue integration concern convergence theorems and the interchange of limits and integrals. The book closes with a section on Fourier series, with a concentration on Fourier coefficients of functions from particular classes and on basic theorems for convergence of Fourier series. The book is primarily geared toward students in analysis, as a study aid, for problem-solving seminars, or for tutorials. It is also an excellent resource for instructors who wish to incorporate problems into their lectures. Solutions for the problems are provided in the boo...

An Integrated Approach to Biology

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 16; Issue 8. An Integrated Approach to Biology. Aniket Bhattacharya. General Article Volume 16 Issue 8 August 2011 pp 742-753. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/016/08/0742-0753 ...

Phantom study of PET/CT guided delineation of radiation therapy volume

International Nuclear Information System (INIS)

Lin Lin; Zheng Rong; Wang Yibin; Geng Jianhua; Wu Ning; Zhao Ping

2012-01-01

Objective: To propose a model-based method for calculating the threshold in GTV determination by 18 F-FDG PET in a phantom study. Methods: A phantom was constructed of a 9 L cylindrical tank.Glass spheres with volumes ranging from 0.5 to 16 ml (0.5, 1, 2, 4, 8 and 16 ml) were suspended within the tank. The six spheres were filled with an identical concentration of FDG (203.5 MBq/L) and suspended within 3 different background baths of FDG (6.179, 16.021, 0 MBq/L) solutions, creating 3 target-to-background ratios of 32.96 : 1, 12.69 : 1 and target to zero background. A linear regressive function was constructed which represented the relationship between the threshold and the average activity concentration of the target. A 40% of maximum intensity threshold and the linear regressive function method were applied to define the spheres filled with 18 F-FDG. The volume differences between the two methods and the true volumes of the spheres were compared with t-test. Results: The linear regressive function model was derived as:threshold =(mean target concentration + 2.6227)/1.9752. The results indicated that a smaller deviation occurred when the function was utilized to estimate the volumes of the phantoms as compared to the 40% of maximum intensity threshold method, but there were no significant differences between them (t=0.306, P>0.05). The effect of the linear regressive function on volume was such that when the phantom sphere volumes were ≥ 1 ml, the average deviation between the defined volumes and the true volumes of phantoms was 1.01%; but when the phantom sphere volume was 0.5 ml, the average deviation was 9.53%. When the 40% of maximum intensity threshold method was applied to define the phantom spheres of volume ≥2 ml, the average deviation between the defined volumes and the true volumes of phantoms was -4.62%; but, the average deviation of that was 19.9% when the volumes of spheres were 0.5 and 1 ml. When the linear regressive function was applied to

Chemical sensitive interfacial free volume studies of nanophase Al-rich alloys

International Nuclear Information System (INIS)

Lechner, W.; Puff, W.; Wuerschum, R.; Wilde, G.

2006-01-01

Full text: Al-based nanocrystalline alloys have attracted substantial interest due to their outstanding mechanical properties. These alloys can be obtained by crystallization of melt-spun amorphous precursors or by grain refinement upon repeated cold-rolling of elemental layers. For both synthesis routes, the nanocrystallization process is sensitively affected by interfacial chemistry and free volumes. In order to contribute to an atomistic understanding of the interfacial structure and processes during nanocrystallization, the present work deals with studies of interfacial free volumes by means of positron-annihilation-spectroscopy. In addition to positron lifetime spectroscopy which yields information on the size of free volumes, coincident Doppler broadening of the positron-electron annihilation photons is applied as novel technique for studying the chemistry of interfaces in nanophase materials on an atomistic scale. Al-rich alloys of the above mentioned synthesis routes were studied in this work. (author)

Using high-order polynomial basis in 3-D EM forward modeling based on volume integral equation method

Science.gov (United States)

Kruglyakov, Mikhail; Kuvshinov, Alexey

2018-05-01

3-D interpretation of electromagnetic (EM) data of different origin and scale becomes a common practice worldwide. However, 3-D EM numerical simulations (modeling)—a key part of any 3-D EM data analysis—with realistic levels of complexity, accuracy and spatial detail still remains challenging from the computational point of view. We present a novel, efficient 3-D numerical solver based on a volume integral equation (IE) method. The efficiency is achieved by using a high-order polynomial (HOP) basis instead of the zero-order (piecewise constant) basis that is invoked in all routinely used IE-based solvers. We demonstrate that usage of the HOP basis allows us to decrease substantially the number of unknowns (preserving the same accuracy), with corresponding speed increase and memory saving.

Tumor response parameters for head and neck cancer derived from tumor-volume variation during radiation therapy

International Nuclear Information System (INIS)

Chvetsov, Alexei V.

2013-01-01

Purpose: The main goal of this paper is to reconstruct a distribution of cell survival fractions from tumor-volume variation for a heterogeneous group of head and neck cancer patients and compare this distribution to the data from predictive assays. Methods: To characterize the tumor-volume variation during radiation therapy treatment, the authors use a two-level tumor-volume model of cell population that separates the entire tumor cell population into two subpopulations of viable cells and lethally damaged cells. This parameterized radiobiological model is integrated with a least squares objective function and a simulated annealing optimization algorithm to describe time-dependent tumor-volume variation rates in individual patients. Several constraints have been used in the optimization problem because tumor-volume variation during radiotherapy is described by a sum of exponentials; therefore, the problem of accurately fitting a model to measured data is ill-posed. The model was applied to measured tumor-volume variation curves from a clinical study on tumor-volume variation during radiotherapy for 14 head and neck cancer patients in which an integrated CT/linear particle accelerator (LINAC) system was used for tumor-volume measurements. Results: The two-level cell population tumor-volume modeling is capable of describing tumor-volume variation throughout the entire treatment for 11 of the 14 patients. For three patients, the tumor-volume variation was described only during the initial part of treatment, a fact that may be related to the neglected hypoxia in the two-level approximation. The predicted probability density distribution for the survival fractions agrees with the data obtained using in vitro studies with predictive assays. The mean value 0.35 of survival fraction obtained in this study is larger than the value 0.32 from in vitro studies, which could be expected because of greater repair in vivo. The mean half-life obtained in this study for the head

Integration of Diagnostics into Ground Equipment Study. Volume 1

National Research Council Canada - National Science Library

Kumara, Soundar; Gautam, N; Hall, Dave; Purao, Sandeep; Garga, Amulya; Grimes, Barney

2004-01-01

...) for Ground Equipment used by the U.S. Marine Corps. The study reviewed the sources of Autonomic Logistics data, the data requirements, the timeliness or required "pull" of such data, its transmission means...

CanWEA Pan-Canadian wind integration study paper

Energy Technology Data Exchange (ETDEWEB)

Tremblay, Martin [GL Garrad Hassan Canada Inc, Ottawa, ON (Canada); Gardner, Paul [GL Garrad Hassan and Partners, Glasgow (United Kingdom); Price, Doug; Le, Don [GL Garrad Hassan America, San Diego, CA (United States)

2010-07-01

GL Garrad Hassan has been contracted by CanWEA to undertake a scoping study for a future Pan-Canadian Wide-Scale Wind Integration Study. The scoping study provides the methodology and the rationale on which the actual wind integration study and request for proposals will be based on. Major system operators and owners of each Canadian Province along with experts involved in major US wind integration studies have been consulted and contributed to the decisional process. This paper provides a summary of the factors considered in the study and outline the actual methodology that was adopted for the future Pan-Canadian wind integration study. (orig.)

Colorado Conference on iterative methods. Volume 1

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-12-31

The conference provided a forum on many aspects of iterative methods. Volume I topics were:Session: domain decomposition, nonlinear problems, integral equations and inverse problems, eigenvalue problems, iterative software kernels. Volume II presents nonsymmetric solvers, parallel computation, theory of iterative methods, software and programming environment, ODE solvers, multigrid and multilevel methods, applications, robust iterative methods, preconditioners, Toeplitz and circulation solvers, and saddle point problems. Individual papers are indexed separately on the EDB.

Design and evaluation of potentiometric principles for bladder volume monitoring: a preliminary study.

Science.gov (United States)

Chen, Shih-Ching; Hsieh, Tsung-Hsun; Fan, Wen-Jia; Lai, Chien-Hung; Chen, Chun-Lung; Wei, Wei-Feng; Peng, Chih-Wei

2015-06-01

Recent advances in microelectronics and wireless transmission technology have led to the development of various implantable sensors for real-time monitoring of bladder conditions. Although various sensing approaches for monitoring bladder conditions were reported, most such sensors have remained at the laboratory stage due to the existence of vital drawbacks. In the present study, we explored a new concept for monitoring the bladder capacity on the basis of potentiometric principles. A prototype of a potentiometer module was designed and fabricated and integrated with a commercial wireless transmission module and power unit. A series of in vitro pig bladder experiments was conducted to determine the best design parameters for implementing the prototype potentiometric device and to prove its feasibility. We successfully implemented the potentiometric module in a pig bladder model in vitro, and the error of the accuracy of bladder volume detection was design principles and animal experience gathered from this research can serve as a basis for developing new implantable bladder sensors in the future.

Bird Conservation Implementation and Integration in the Americas: Proceedings of the Third International Partners in Flight Conference. 2002 March 20-24; Asilomar, California, Volume 1 and 2

Science.gov (United States)

C. John Ralph; Terrell D. Rich

2005-01-01

These two volumes contain in part papers presented at the Third International Partners in Flight Conference: A Workshop on Bird Conservation Implementation and Integration, which was held 20-24 March 2002 at the Asilomar Conference Center in Monterey, California. The conference gathered together researchers, educators, foresters, monitoring specialists, planners, and...

A Curriculum Activities Guide to Water Pollution and Environmental Studies, Volume II - Appendices.

Science.gov (United States)

Hershey, John T., Ed.; And Others

This publication, Volume II of a two volume set of water pollution studies, contains seven appendices which support the studies. Appendix 1, Water Quality Parameters, consolidates the technical aspects of water quality including chemical, biological, computer program, and equipment information. Appendix 2, Implementation, outlines techniques…

An Integrated Theory of Everything (TOE)

Science.gov (United States)

Colella, Antonio

2014-03-01

An Integrated TOE unifies all known physical phenomena from the Planck cube to the Super Universe (multiverse). Each matter/force particle is represented by a Planck cube string. Any Super Universe object is a volume of contiguous Planck cubes. Super force Planck cube string singularities existed at the start of all universes. An Integrated TOE foundations are twenty independent existing theories and without sacrificing their integrities, are replaced by twenty interrelated amplified theories. Amplifications of Higgs force theory are key to an Integrated TOE and include: 64 supersymmetric Higgs particles; super force condensations to 17 matter particles/associated Higgs forces; spontaneous symmetry breaking is bidirectional; and the sum of 8 permanent Higgs force energies is dark energy. Stellar black hole theory was amplified to include a quark star (matter) with mass, volume, near zero temperature, and maximum entropy. A black hole (energy) has energy, minimal volume (singularity), near infinite temperature, and minimum entropy. Our precursor universe's super supermassive quark star (matter) evaporated to a super supermassive black hole (energy). This transferred total conserved energy/mass and transformed entropy from maximum to minimum. Integrated Theory of Everything Book Video: https://www.youtube.com/watch?v=4a1c9IvdoGY Research Article Video: http://www.youtube.com/watch?v=CD-QoLeVbSY Research Article: http://toncolella.files.wordpress.com/2012/07/m080112.pdf.

Optimized waste management: Less volume and less radiotoxicity

International Nuclear Information System (INIS)

Fournier, Ph.; Nigon, J.L.

2001-01-01

This paper describes efforts to optimize fuel cycle back end solid wastes, in order to reduce both volume and radioactivity of final residues. An integrated strategy of standardized conditioning of all residues from reprocessing, called the Universal Canister Strategy, has been adopted. The application of feedback from over 30 years of operating experience and research and development to minimization of waste volume and radioactivity is presented. (author)

Small-Volume Injections: Evaluation of Volume Administration Deviation From Intended Injection Volumes.

Science.gov (United States)

Muffly, Matthew K; Chen, Michael I; Claure, Rebecca E; Drover, David R; Efron, Bradley; Fitch, William L; Hammer, Gregory B

2017-10-01

In the perioperative period, anesthesiologists and postanesthesia care unit (PACU) nurses routinely prepare and administer small-volume IV injections, yet the accuracy of delivered medication volumes in this setting has not been described. In this ex vivo study, we sought to characterize the degree to which small-volume injections (≤0.5 mL) deviated from the intended injection volumes among a group of pediatric anesthesiologists and pediatric postanesthesia care unit (PACU) nurses. We hypothesized that as the intended injection volumes decreased, the deviation from those intended injection volumes would increase. Ten attending pediatric anesthesiologists and 10 pediatric PACU nurses each performed a series of 10 injections into a simulated patient IV setup. Practitioners used separate 1-mL tuberculin syringes with removable 18-gauge needles (Becton-Dickinson & Company, Franklin Lakes, NJ) to aspirate 5 different volumes (0.025, 0.05, 0.1, 0.25, and 0.5 mL) of 0.25 mM Lucifer Yellow (LY) fluorescent dye constituted in saline (Sigma Aldrich, St. Louis, MO) from a rubber-stoppered vial. Each participant then injected the specified volume of LY fluorescent dye via a 3-way stopcock into IV tubing with free-flowing 0.9% sodium chloride (10 mL/min). The injected volume of LY fluorescent dye and 0.9% sodium chloride then drained into a collection vial for laboratory analysis. Microplate fluorescence wavelength detection (Infinite M1000; Tecan, Mannedorf, Switzerland) was used to measure the fluorescence of the collected fluid. Administered injection volumes were calculated based on the fluorescence of the collected fluid using a calibration curve of known LY volumes and associated fluorescence.To determine whether deviation of the administered volumes from the intended injection volumes increased at lower injection volumes, we compared the proportional injection volume error (loge [administered volume/intended volume]) for each of the 5 injection volumes using a linear

The geometric and arithmetic volume of Shimura varieties of orthogonal type

CERN Document Server

Hörmann, Fritz

2015-01-01

This book outlines a functorial theory of integral models of (mixed) Shimura varieties and of their toroidal compactifications, for odd primes of good reduction. This is the integral version, developed in the author's thesis, of the theory invented by Deligne and Pink in the rational case. In addition, the author develops a theory of arithmetic Chern classes of integral automorphic vector bundles with singular metrics using the work of Burgos, Kramer and Kühn. The main application is calculating arithmetic volumes or "heights" of Shimura varieties of orthogonal type using Borcherds' famous modular forms with their striking product formula-an idea due to Bruinier-Burgos-Kühn and Kudla. This should be seen as an Arakelov analogue of the classical calculation of volumes of orthogonal locally symmetric spaces by Siegel and Weil. In the latter theory, the volumes are related to special values of (normalized) Siegel Eisenstein series. In this book, it is proved that the Arakelov analogues are related to special d...

Correlation between metabolic tumor volume and pathologic tumor volume in squamous cell carcinoma of the oral cavity

International Nuclear Information System (INIS)

Murphy, James D.; Chisholm, Karen M.; Daly, Megan E.; Wiegner, Ellen A.; Truong, Daniel; Iagaru, Andrei; Maxim, Peter G.; Loo, Billy W.; Graves, Edward E.; Kaplan, Michael J.; Kong, Christina; Le, Quynh-Thu

2011-01-01

Purpose: To explore the relationship between pathologic tumor volume and volume estimated from different tumor segmentation techniques on 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in oral cavity cancer. Materials and methods: Twenty-three patients with squamous cell carcinoma of the oral tongue had PET–CT scans before definitive surgery. Pathologic tumor volume was estimated from surgical specimens. Metabolic tumor volume (MTV) was defined from PET–CT scans as the volume of tumor above a given SUV threshold. Multiple SUV thresholds were explored including absolute SUV thresholds, relative SUV thresholds, and gradient-based techniques. Results: Multiple MTV’s were associated with pathologic tumor volume; however the correlation was poor (R 2 range 0.29–0.58). The ideal SUV threshold, defined as the SUV that generates an MTV equal to pathologic tumor volume, was independently associated with maximum SUV (p = 0.0005) and tumor grade (p = 0.024). MTV defined as a function of maximum SUV and tumor grade improved the prediction of pathologic tumor volume (R 2 = 0.63). Conclusions: Common SUV thresholds fail to predict pathologic tumor volume in head and neck cancer. The optimal technique that allows for integration of PET–CT with radiation treatment planning remains to be defined. Future investigation should incorporate biomarkers such as tumor grade into definitions of MTV.

Impact of institutional volume and experience with CT interpretation on sizing of transcatheter aortic valves: A multicenter retrospective study

International Nuclear Information System (INIS)

Verma, Divya Ratan; Pershad, Yash; Pershad, Ashish; Fang, Kenith; Gellert, George; Morris, Michael F.

2016-01-01

Background: Computed tomography (CT) has become the standard imaging modality for pre-procedural aortic annular sizing prior to transcatheter aortic valve replacement (TAVR). We hypothesized that the accuracy of CT derived annular measurements would be greater at sites with higher TAVR procedural volume. Methods: Within a large integrated health system, TAVR was performed at low ( 75 cases). 181 patients underwent TAVR with a Sapien XT transcatheter heart valve (THV). Two blinded experienced readers independently remeasured the annulus on CT and compared their measurements to site reported measurements. Hypothetical THV sizes were chosen based on measurements from site CT reports and independent readers’ measurements, and compared to the implanted THV size. Results: Correlation between site reported measurements and independent readers measurements of mean annulus size varied between low-volume (r = 0.31, p = 0.18), intermediate-volume (r = 0.34, p = 0.01), and high-volume sites (r = 0.96, p < 0.01). On multivariate analysis, interpretation of ≥20 CT scans (OR 0.29; 95% CI 0.03–0.81; p 0.02) and high-volume site (OR 0.16; 95% CI 0.10–0.82; p 0.02) were associated with reduced mismatch between the site predicted THV size and independent readers predicted THV size. Mismatch between site predicted THV size and implanted THV size was associated with a worse 30-day composite of mortality, dialysis-dependent renal failure, cerebrovascular accident, new permanent pacemaker, and hospital readmission (55.3 vs. 38.7%; p = 0.05). Conclusions: Accuracy of CT aortic annular sizing is improved with higher individual experience and site TAVR volume. These findings should be confirmed in larger, prospective studies. - Highlights: • Accuracy of CT aortic annular sizing is improved with higher individual experience and site TAVR volume. • CT readers with experience interpreting ≥20 pre-TAVR CT scans had significantly improved accuracy in identifying the annulus. �

Integral Inequalities for Self-Reciprocal Polynomials

Indian Academy of Sciences (India)

Annual Meetings · Mid Year Meetings · Discussion Meetings · Public Lectures · Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Proceedings – Mathematical Sciences; Volume 120; Issue 2. Integral Inequalities for Self-Reciprocal Polynomials. Horst Alzer. Volume 120 Issue 2 April 2010 ...

INTRA/Mod3.2. Manual and Code Description. Volume I - Physical Modelling

International Nuclear Information System (INIS)

Andersson, Jenny; Edlund, O.; Hermann, J.; Johansson, Lise-Lotte

1999-01-01

The INTRA Manual consists of two volumes. Volume I of the manual is a thorough description of the code INTRA, the Physical modelling of INTRA and the ruling numerical methods and volume II, the User's Manual is an input description. This document, the Physical modelling of INTRA, contains code characteristics, integration methods and applications

INTRA/Mod3.2. Manual and Code Description. Volume I - Physical Modelling

Energy Technology Data Exchange (ETDEWEB)

Andersson, Jenny; Edlund, O; Hermann, J; Johansson, Lise-Lotte

1999-01-01

The INTRA Manual consists of two volumes. Volume I of the manual is a thorough description of the code INTRA, the Physical modelling of INTRA and the ruling numerical methods and volume II, the User`s Manual is an input description. This document, the Physical modelling of INTRA, contains code characteristics, integration methods and applications

Cannula Tip With Integrated Volume Sensor for Rotary Blood Pump Control: Early-Stage Development.

Science.gov (United States)

Cysyk, Joshua; Newswanger, Ray; Popjes, Eric; Pae, Walter; Jhun, Choon-Sik; Izer, Jenelle; Weiss, William; Rosenberg, Gerson

2018-05-10

The lack of direct measurement of left ventricular unloading is a significant impediment to the development of an automatic speed control system for continuous-flow left ventricular assist devices (cf-LVADs). We have developed an inlet cannula tip for cf-LVADs with integrated electrodes for volume sensing based on conductance. Four platinum-iridium ring electrodes were installed into grooves on a cannula body constructed from polyetheretherketone (PEEK). A sinusoidal current excitation waveform (250 μA pk-pk, 50 kHz) was applied across one pair of electrodes, and the conductance-dependent voltage was sensed across the second pair of electrodes. The conductance catheter was tested in an acute ovine model (n = 3) in conjunction with the HeartMate II rotary blood pump to provide circulatory support and unload the ventricle. Echocardiography was used to measure ventricular size during pump support for verification for the conductance measurements. The conductance measurements correlated linearly with the echocardiography dimension measurements more than the full range of pump support from minimum support to suction. This cannula tip will enable the development of automatic control systems to optimize pump support based on a real-time measurement of ventricular size.

Twenty-third water reactor safety information meeting. Volume 3, structural and seismic engineering, primary systems integrity, equipment operability and aging, ECCS strainer blockage research and regulatory issues

Energy Technology Data Exchange (ETDEWEB)

Monteleone, S. [comp.] [Brookhaven National Lab., Upton, NY (United States)

1996-03-01

This three-volume report contains papers presented at the Twenty- Third Water Reactor Safety Information Meeting held at the Bethesda Marriott Hotel, Bethesda, Maryland, October 23-25, 1995. The papers are printed in the order of their presentation in each session and describe progress and results of programs in nuclear safety research conducted in this country and abroad. Foreign participation in the meeting included papers presented by researchers from France, Italy, Japan, Norway, Russia, Sweden, and Switzerland. This document, Volume 3, presents topics in Structural & Seismic Engineering, Primary Systems Integrity, Equipment Operability and Aging, and ECCS Strainer Blockage Research & Regulatory Issues. Individual papers have been cataloged separately.

Twenty-third water reactor safety information meeting. Volume 3, structural and seismic engineering, primary systems integrity, equipment operability and aging, ECCS strainer blockage research and regulatory issues

International Nuclear Information System (INIS)

Monteleone, S.

1996-03-01

This three-volume report contains papers presented at the Twenty- Third Water Reactor Safety Information Meeting held at the Bethesda Marriott Hotel, Bethesda, Maryland, October 23-25, 1995. The papers are printed in the order of their presentation in each session and describe progress and results of programs in nuclear safety research conducted in this country and abroad. Foreign participation in the meeting included papers presented by researchers from France, Italy, Japan, Norway, Russia, Sweden, and Switzerland. This document, Volume 3, presents topics in Structural ampersand Seismic Engineering, Primary Systems Integrity, Equipment Operability and Aging, and ECCS Strainer Blockage Research ampersand Regulatory Issues. Individual papers have been cataloged separately

When high-volume PCI operators in high-volume hospitals move to lower volume hospitals-Do they still maintain high volume and quality of outcomes?

Science.gov (United States)

Lu, Tsung-Hsueh; Li, Sheng-Tun; Liang, Fu-Wen; Lee, Jo-Chi; Yin, Wei-Hsian

2017-10-31

The aim of this quasi-experimental study was to examine whether high-volume percutaneous coronary intervention (PCI) operators still maintain high volume and quality of outcomes when they moved to lower volume hospitals. Systematic reviews have indicated that high-volume PCI operators and hospitals have higher quality outcomes. However, little is known on whether high PCI volume and high quality outcomes are mainly due to operator characteristics (i.e., skill and experience) and is portable across organizations or whether it is due to hospital characteristics (i.e., equipment, team, and management system) and is less portable. We used Taiwan National Health Insurance claims data 2000-2012 to identify 98 high-volume PCI operators, 10 of whom moved from one hospital to another during the study period. We compared the PCI volume, risk-adjusted mortality ratio, and major adverse cardiovascular event (MACE) ratio before and after moving. Of the 10 high-volume operators who moved, 6 moved from high- to moderate- or low-volume hospitals, with median annual PCI volumes (interquartile range) of 130 (117-165) in prior hospitals and 54 (46-84) in subsequent hospitals (the hospital the operator moved to), and the remaining 4 moved from high to high-volume hospitals, with median annual PCI volumes (interquartile range) of 151 (133-162) in prior hospitals and 193 (178-239) in subsequent hospitals. No significant differences were observed in the risk-adjusted mortality ratios and MACE ratios between high-volume operators and matched controls before and after moving. High-volume operators cannot maintain high volume when they moved from high to moderate or low-volume hospitals; however, the quality of care is maintained. High PCI volume and high-quality outcomes are less portable and more hospital bound. © 2017 Wiley Periodicals, Inc.

Multimodal evidence of regional midcingulate gray matter volume underlying conflict monitoring

Science.gov (United States)

Parvaz, Muhammad A.; Maloney, Thomas; Moeller, Scott J.; Malaker, Pias; Konova, Anna B.; Alia-Klein, Nelly; Goldstein, Rita Z.

2014-01-01

Functional neuroimaging studies have long implicated the mid-cingulate cortex (MCC) in conflict monitoring, but it is not clear whether its structural integrity (i.e., the gray matter volume) influences its conflict monitoring function. In this multimodal study, we used T1-weighted MRI scans as well as event-related potentials (ERPs) to test whether the MCC gray matter volume is associated with the electrocortical marker (i.e., No-go N200 ERP component) of conflict monitoring in healthy individuals. The specificity of such a relationship in health was determined in two ways: by (A) acquiring the same data from individuals with cocaine use disorder (CUD), known to have deficits in executive function including behavioral monitoring; and (B) acquiring the P300 ERP component that is linked with attention allocation and not specifically with conflict monitoring. Twenty-five (39.1 ± 8.4 years; 8 females) healthy individuals and 25 (42.7 ± 5.9 years; 6 females) individuals with CUD underwent a rewarded Go/No-go task during which the ERP data was collected, and they also underwent a structural MRI scan. The whole brain regression analysis showed a significant correlation between MCC structural integrity and the well-known ERP measure of conflict monitoring (N200, but not the P300) in healthy individuals, which was absent in CUD who were characterized by reduced MCC gray matter volume, N200 abnormalities as well as reduced task accuracy. In individuals with CUD instead, the N200 amplitude was associated with drug addiction symptomatology. These results show that the integrity of MCC volume is directly associated with the electrocortical correlates of conflict monitoring in healthy individuals, and such an association breaks down in psychopathologies that impact these brain processes. Taken together, this MCC–N200 association may serve as a biomarker of improved behavioral monitoring processes in diseased populations. PMID:24918068

Multimodal evidence of regional midcingulate gray matter volume underlying conflict monitoring

Directory of Open Access Journals (Sweden)

Muhammad A. Parvaz

2014-01-01

Full Text Available Functional neuroimaging studies have long implicated the mid-cingulate cortex (MCC in conflict monitoring, but it is not clear whether its structural integrity (i.e., the gray matter volume influences its conflict monitoring function. In this multimodal study, we used T1-weighted MRI scans as well as event-related potentials (ERPs to test whether the MCC gray matter volume is associated with the electrocortical marker (i.e., No-go N200 ERP component of conflict monitoring in healthy individuals. The specificity of such a relationship in health was determined in two ways: by (A acquiring the same data from individuals with cocaine use disorder (CUD, known to have deficits in executive function including behavioral monitoring; and (B acquiring the P300 ERP component that is linked with attention allocation and not specifically with conflict monitoring. Twenty-five (39.1 ± 8.4 years; 8 females healthy individuals and 25 (42.7 ± 5.9 years; 6 females individuals with CUD underwent a rewarded Go/No-go task during which the ERP data was collected, and they also underwent a structural MRI scan. The whole brain regression analysis showed a significant correlation between MCC structural integrity and the well-known ERP measure of conflict monitoring (N200, but not the P300 in healthy individuals, which was absent in CUD who were characterized by reduced MCC gray matter volume, N200 abnormalities as well as reduced task accuracy. In individuals with CUD instead, the N200 amplitude was associated with drug addiction symptomatology. These results show that the integrity of MCC volume is directly associated with the electrocortical correlates of conflict monitoring in healthy individuals, and such an association breaks down in psychopathologies that impact these brain processes. Taken together, this MCC–N200 association may serve as a biomarker of improved behavioral monitoring processes in diseased populations.

Multimodal evidence of regional midcingulate gray matter volume underlying conflict monitoring.

Science.gov (United States)

Parvaz, Muhammad A; Maloney, Thomas; Moeller, Scott J; Malaker, Pias; Konova, Anna B; Alia-Klein, Nelly; Goldstein, Rita Z

2014-01-01

Functional neuroimaging studies have long implicated the mid-cingulate cortex (MCC) in conflict monitoring, but it is not clear whether its structural integrity (i.e., the gray matter volume) influences its conflict monitoring function. In this multimodal study, we used T1-weighted MRI scans as well as event-related potentials (ERPs) to test whether the MCC gray matter volume is associated with the electrocortical marker (i.e., No-go N200 ERP component) of conflict monitoring in healthy individuals. The specificity of such a relationship in health was determined in two ways: by (A) acquiring the same data from individuals with cocaine use disorder (CUD), known to have deficits in executive function including behavioral monitoring; and (B) acquiring the P300 ERP component that is linked with attention allocation and not specifically with conflict monitoring. Twenty-five (39.1 ± 8.4 years; 8 females) healthy individuals and 25 (42.7 ± 5.9 years; 6 females) individuals with CUD underwent a rewarded Go/No-go task during which the ERP data was collected, and they also underwent a structural MRI scan. The whole brain regression analysis showed a significant correlation between MCC structural integrity and the well-known ERP measure of conflict monitoring (N200, but not the P300) in healthy individuals, which was absent in CUD who were characterized by reduced MCC gray matter volume, N200 abnormalities as well as reduced task accuracy. In individuals with CUD instead, the N200 amplitude was associated with drug addiction symptomatology. These results show that the integrity of MCC volume is directly associated with the electrocortical correlates of conflict monitoring in healthy individuals, and such an association breaks down in psychopathologies that impact these brain processes. Taken together, this MCC-N200 association may serve as a biomarker of improved behavioral monitoring processes in diseased populations.

USAF Logistics Process Optimization Study for the Aircraft Asset Sustainment Process. Volume 2

National Research Council Canada - National Science Library

Adamson, Anthony

1998-01-01

.... It is published as three separate volumes. Volume I, USAF Logistics Process Optimization Study for the Aircraft Asset Sustainment Process -- Phase II Report, discusses the result and cost/benefit analysis of testing three initiatives...

USAF Logistics Process Optimization Study for the Aircraft Asset Sustainment Process. Volume 1

National Research Council Canada - National Science Library

Adamson, Anthony

1998-01-01

.... It is published as three separate volumes. Volume I, USAF Logistics Process Optimization Study for the Aircraft Asset Sustainment Process -- Phase II Report, discusses the result and cost/benefit analysis of testing three initiatives...

Optimization of total arc degree for stereotactic radiotherapy by using integral biologically effective dose and irradiated volume

International Nuclear Information System (INIS)

Lim, Do Hoon; Kim, Dae Yong; Lee, Myung Za; Chun, Ha Chung

2001-01-01

To find the optimal values of total arc degree to protect the normal brain tissue from high dose radiation in stereotactic radiotherapy planning. With Xknife-3 planning system and 4 MV linear accelerator, the authors planned under various values of parameters. One isocenter, 12, 20, 30, 40, 50, and 60 mm of collimator diameters, 100 deg, 200 deg, 300 deg, 400 deg, 500 deg, 600 deg, of total arc degrees, and 30 deg or 45 deg of arc intervals were used. After the completion of planning, the plans were compared each other using V 50 (the volume of normal brain that is delivered high dose radiation) and integral biologically effective dose. At 30 deg of arc interval, the values of V 50 had the decreased pattern with the increase of total arc degree in any collimator diameter. At 45 deg arc interval, up to 400 deg of total arc degree, the values of V 50 decreased with the increase of total arc degree, but at 500 deg and 600 deg of total arc degrees, the values increased. At 30 deg of arc interval, integral biologically effective dose showed the decreased pattern with the increase of total arc degree in any collimator diameter. At 45 deg arc interval with less than 40 mm collimator diameter, the integral biologically effective dose decreased with the increase of total arc degree, but with 50 and 60 mm of collimator diameters, up to 400 deg of total arc degree, integral biologically effective dose decreased with the increase of total arc degree, but at 500 deg and 600 deg of total arc degrees, the values increased. In the stereotactic radiotherapy planning for brain lesions, planning with 400 deg of total arc degree is optimal. Especially, when the larger collimator more than 50 mm diameter should be used, the uses of 500 deg and 600 deg of total arc degrees make the increase of V 50 and integral biologically effective dose, Therefore stereotactic radiotherapy planning using 400 deg of total arc degree can increase the therapeutic ratio and produce the effective outcome

Novel genetic loci associated with hippocampal volume

NARCIS (Netherlands)

D.P. Hibar (Derrek); H.H.H. Adams (Hieab); N. Jahanshad (Neda); G. Chauhan (Ganesh); J.L. Stein; E. Hofer (Edith); M.E. Rentería (Miguel); J.C. Bis (Joshua); A. Arias-Vásquez (Alejandro); Ikram, M.K. (M. Kamran); S. Desrivières (Sylvane); M.W. Vernooij (Meike); L. Abramovic (Lucija); S. Alhusaini (Saud); N. Amin (Najaf); M. Andersson (Micael); K. Arfanakis (Konstantinos); B. Aribisala (Benjamin); N.J. Armstrong (Nicola J.); L. Athanasiu (Lavinia); T. Axelsson (Tomas); A.H. Beecham (Ashley); A. Beiser (Alexa); M. Bernard (Manon); S.H. Blanton (Susan H.); M.M. Bohlken (Marc M.); M.P.M. Boks (Marco); L.B.C. Bralten (Linda); A.M. Brickman (Adam M.); Carmichael, O. (Owen); M.M. Chakravarty (M. Mallar); Q. Chen (Qiang); C.R.K. Ching (Christopher); V. Chouraki (Vincent); G. Cuellar-Partida (Gabriel); F. Crivello (Fabrice); A. den Braber (Anouk); Doan, N.T. (Nhat Trung); S.M. Ehrlich (Stefan); S. Giddaluru (Sudheer); A.L. Goldman (Aaron L.); R.F. Gottesman (Rebecca); O. Grimm (Oliver); M.D. Griswold (Michael); T. Guadalupe (Tulio); Gutman, B.A. (Boris A.); J. Hass (Johanna); U.K. Haukvik (Unn); D. Hoehn (David); A.J. Holmes (Avram); M. Hoogman (Martine); D. Janowitz (Deborah); T. Jia (Tianye); Jørgensen, K.N. (Kjetil N.); N. Karbalai (Nazanin); D. Kasperaviciute (Dalia); S. Kim (Shinseog); M. Klein (Marieke); B. Kraemer (Bernd); P.H. Lee (Phil); D.C. Liewald (David C.); L.M. Lopez (Lorna); M. Luciano (Michelle); C. MacAre (Christine); Marquand, A.F. (Andre F.); M. Matarin (Mar); R. Mather; M. Mattheisen (Manuel); McKay, D.R. (David R.); Milaneschi, Y. (Yuri); S. Muñoz Maniega (Susana); K. Nho (Kwangsik); A.C. Nugent (Allison); P. Nyquist (Paul); Loohuis, L.M.O. (Loes M. Olde); J. Oosterlaan (Jaap); M. Papmeyer (Martina); Pirpamer, L. (Lukas); B. Pütz (Benno); A. Ramasamy (Adaikalavan); Richards, J.S. (Jennifer S.); S.L. Risacher (Shannon); R. Roiz-Santiañez (Roberto); N. Rommelse (Nanda); S. Ropele (Stefan); E.J. Rose (Emma); N.A. Royle (Natalie); T. Rundek (Tatjana); P.G. Sämann (Philipp); Saremi, A. (Arvin); C.L. Satizabal (Claudia L.); L. Schmaal (Lianne); N.J. Schork (Nicholas); Shen, L. (Li); J. Shin (Jean); Shumskaya, E. (Elena); A.V. Smith (Albert Vernon); R. Sprooten (Roy); L.T. Strike (Lachlan); A. Teumer (Alexander); D. Tordesillas-Gutierrez (Diana); R. Toro (Roberto); D. Trabzuni (Danyah); S. Trompet (Stella); D. Vaidya (Dhananjay); J. van der Grond (Jeroen); S.J. van der Lee (Sven); Van Der Meer, D. (Dennis); M.M.J. Van Donkelaar (Marjolein M. J.); K.R. van Eijk (Kristel); T.G.M. van Erp (Theo G.); Van Rooij, D. (Daan); E. Walton (Esther); L.T. Westlye (Lars); C.D. Whelan (Christopher); B.G. Windham (B Gwen); A.M. Winkler (Anderson); K. Wittfeld (Katharina); G. Woldehawariat (Girma); A. Björnsson (Asgeir); Wolfers, T. (Thomas); L.R. Yanek (Lisa); Yang, J. (Jingyun); A.P. Zijdenbos; M.P. Zwiers (Marcel); I. Agartz (Ingrid); L. Almasy (Laura); D.J. Ames (David); Amouyel, P. (Philippe); O.A. Andreassen (Ole); S. Arepalli (Sampath); A.A. Assareh; S. Barral (Sandra); M.E. Bastin (Mark); Becker, D.M. (Diane M.); J.T. Becker (James); D.A. Bennett (David A.); J. Blangero (John); H. van Bokhoven (Hans); D.I. Boomsma (Dorret); H. Brodaty (Henry); R.M. Brouwer (Rachel); H.G. Brunner; M. Buckner; J.K. Buitelaar (Jan); K. Bulayeva (Kazima); W. Cahn (Wiepke); V.D. Calhoun Vince D. (V.); D.M. Cannon (Dara); G. Cavalleri (Gianpiero); Cheng, C.-Y. (Ching-Yu); S. Cichon (Sven); M.R. Cookson (Mark); A. Corvin (Aiden); B. Crespo-Facorro (Benedicto); J.E. Curran (Joanne); M. Czisch (Michael); A.M. Dale (Anders); G.E. Davies (Gareth); A.J. de Craen (Anton); E.J.C. de Geus (Eco); P.L. de Jager (Philip); G.I. de Zubicaray (Greig); I.J. Deary (Ian J.); S. Debette (Stéphanie); C. DeCarli (Charles); N. Delanty; C. Depondt (Chantal); A.L. DeStefano (Anita); A. Dillman (Allissa); S. Djurovic (Srdjan); D.J. Donohoe (Dennis); D.A. Drevets (Douglas); Duggirala, R. (Ravi); M.D. Dyer (Matthew); C. Enzinger (Christian); S. Erk; T. Espeseth (Thomas); Fedko, I.O. (Iryna O.); Fernández, G. (Guillén); L. Ferrucci (Luigi); S.E. Fisher (Simon); D. Fleischman (Debra); I. Ford (Ian); M. Fornage (Myriam); T. Foroud (Tatiana); P.T. Fox (Peter); C. Francks (Clyde); Fukunaga, M. (Masaki); Gibbs, J.R. (J. Raphael); D.C. Glahn (David); R.L. Gollub (Randy); H.H.H. Göring (Harald H.); R.C. Green (Robert C.); O. Gruber (Oliver); V. Gudnason (Vilmundur); S. Guelfi (Sebastian); Håberg, A.K. (Asta K.); N.K. Hansell (Narelle); J. Hardy (John); C.A. Hartman (C.); Hashimoto, R. (Ryota); K. Hegenscheid (Katrin); J. Heinz (Judith); S. Le Hellard (Stephanie); D.G. Hernandez (Dena); D.J. Heslenfeld (Dirk); Ho, B.-C. (Beng-Choon); P.J. Hoekstra (Pieter); W. Hoffmann (Wolfgang); A. Hofman (Albert); F. Holsboer (Florian); G. Homuth (Georg); N. Hosten (Norbert); J.J. Hottenga (Jouke Jan); M.J. Huentelman (Matthew); H.H. Pol; Ikeda, M. (Masashi); Jack, C.R. (Clifford R.); S. Jenkinson (Sarah); R. Johnson (Robert); Jönsson, E.G. (Erik G.); J.W. Jukema; R. Kahn (René); Kanai, R. (Ryota); I. Kloszewska (Iwona); Knopman, D.S. (David S.); P. Kochunov (Peter); Kwok, J.B. (John B.); S. Lawrie (Stephen); H. Lemaître (Herve); X. Liu (Xinmin); D.L. Longo (Dan L.); O.L. Lopez (Oscar L.); S. Lovestone (Simon); Martinez, O. (Oliver); J.-L. Martinot (Jean-Luc); V.S. Mattay (Venkata S.); McDonald, C. (Colm); A.M. McIntosh (Andrew); McMahon, F.J. (Francis J.); McMahon, K.L. (Katie L.); P. Mecocci (Patrizia); I. Melle (Ingrid); Meyer-Lindenberg, A. (Andreas); S. Mohnke (Sebastian); Montgomery, G.W. (Grant W.); D.W. Morris (Derek W); T.H. Mosley (Thomas H.); T.W. Mühleisen (Thomas); B. Müller-Myhsok (B.); M.A. Nalls (Michael); M. Nauck (Matthias); T.E. Nichols (Thomas); W.J. Niessen (Wiro); M.M. Nöthen (Markus); L. Nyberg (Lars); Ohi, K. (Kazutaka); R.L. Olvera (Rene); R.A. Ophoff (Roel); M. Pandolfo (Massimo); T. Paus (Tomas); Z. Pausova (Zdenka); B.W.J.H. Penninx (Brenda); Pike, G.B. (G. Bruce); S.G. Potkin (Steven); B.M. Psaty (Bruce); S. Reppermund; M. Rietschel (Marcella); J.L. Roffman (Joshua); N. Seiferth (Nina); J.I. Rotter (Jerome I.); M. Ryten (Mina); Sacco, R.L. (Ralph L.); P.S. Sachdev (Perminder); A.J. Saykin (Andrew); R. Schmidt (Reinhold); Schmidt, H. (Helena); C.J. Schofield (Christopher); Sigursson, S. (Sigurdur); Simmons, A. (Andrew); A. Singleton (Andrew); S.M. Sisodiya (Sanjay); Smith, C. (Colin); J.W. Smoller; H. Soininen (H.); V.M. Steen (Vidar); D.J. Stott (David J.); J. Sussmann (Jessika); A. Thalamuthu (Anbupalam); A.W. Toga (Arthur W.); B. Traynor (Bryan); J.C. Troncoso (Juan); M. Tsolaki (Magda); C. Tzourio (Christophe); A.G. Uitterlinden (André); Hernández, M.C.V. (Maria C. Valdés); M.P. van der Brug (Marcel); A. van der Lugt (Aad); N.J. van der Wee (Nic); N.E.M. van Haren (Neeltje E.); D. van 't Ent (Dennis); M.J.D. van Tol (Marie-José); B.N. Vardarajan (Badri); B. Vellas (Bruno); D.J. Veltman (Dick); H. Völzke (Henry); H.J. Walter (Henrik); J. Wardlaw (Joanna); A.M.J. Wassink (Annemarie); M.E. Weale (Michael); Weinberger, D.R. (Daniel R.); Weiner, M.W. (Michael W.); Wen, W. (Wei); E. Westman (Eric); T.J.H. White (Tonya); Wong, T.Y. (Tien Y.); Wright, C.B. (Clinton B.); R.H. Zielke (Ronald H.); A.B. Zonderman; N.G. Martin (Nicholas); C.M. van Duijn (Cornelia); M.J. Wright (Margaret); W.T. Longstreth Jr; G. Schumann (Gunter); H.J. Grabe (Hans Jörgen); B. Franke (Barbara); L.J. Launer (Lenore); S.E. Medland (Sarah Elizabeth); S. Seshadri (Sudha); P.M. Thompson (Paul); M.K. Ikram (Kamran)

2017-01-01

textabstractThe hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic

A Review of Integrated Courses in Pharmacy Education and Impact of Integration in Pharm D Curricula

Directory of Open Access Journals (Sweden)

Maryam Nikanmehr

2017-03-01

Full Text Available Today, due to ever-increasing knowledge and large volumes of information, educational planners of various fields around the world, have been seeking to establish a better and faster refresh for learning. Integration can be a good educational strategy by blending different subjects and contents when presented to students. The aim of this study is to evaluate the medical literature about integration in the curriculum; its process, importance, necessity and different types of it.This review article was prepared by searching the PubMed database, Google Scholar and science direct websites, national and international journals in the field of medical education curricula. The keywords were educational planning, curriculum integration, and medical education with integration and incorporation.Integration and its eleven steps can be an important strategy in educational planning. According to various studies, integration can enhance the students’ learning and skills in medicinal and pharmaceutical care. It also improves the satisfaction of faculty and students, the quality of education and increases the students’ grades at their examinations. Considering the proper planning, cooperation and co-teaching of faculty members, focus on the desired performance of students and correct assessment of the fundamental principles of integration are crucial to this strategy.

Advances in Planar and Integrated Magnetics

DEFF Research Database (Denmark)

Ouyang, Ziwei

of this thesis is investigated. The history and the evolution of integrated magnetics in power converters have been described. It is recalled, that integrated magnetics allows less number of parts, lower volume and cost of the converter, and higher efficiency. Many innovative ideas are proposed...

Integrative health coaching: an organizational case study.

Science.gov (United States)

Wolever, Ruth Q; Caldwell, Karen L; Wakefield, Jessica P; Little, Kerry J; Gresko, Jeanne; Shaw, Andrea; Duda, Linda V; Kosey, Julie M; Gaudet, Tracy

2011-01-01

The aim of this study was to describe integrative health (IH) coaching as developed in three different interventions offered through a major medical center, as a step toward further defining the field of health coaching. An organizational case study was conducted with document analysis and interviews. Interviewees were the first six IH coaches at Duke Integrative Medicine who provided 360 clients with individual and/or group coaching (two to 28 sessions) in a randomized clinical study and two work-site wellness programs. Qualitative analysis using the constant comparative method was conducted. Integrative health coaching is characterized by a process of self-discovery that informs goal setting and builds internal motivation by linking clients' goals to their values and sense of purpose. Time, commitment, and motivation are necessary in the IH coaching process. The underpinnings of IH coaching are distinct from the medical model, and the process is distinct from health education, executive coaching, and psychotherapy. Integrative health coaching fits well with the assumptions of integrative medicine and has a role in supporting behavior change. Copyright © 2011. Published by Elsevier Inc.

An explicit marching on-in-time solver for the time domain volume magnetic field integral equation

KAUST Repository

Sayed, Sadeed Bin

2014-07-01

Transient scattering from inhomogeneous dielectric objects can be modeled using time domain volume integral equations (TDVIEs). TDVIEs are oftentimes solved using marching on-in-time (MOT) techniques. Classical MOT-TDVIE solvers expand the field induced on the scatterer using local spatio-temporal basis functions. Inserting this expansion into the TDVIE and testing the resulting equation in space and time yields a system of equations that is solved by time marching. Depending on the type of the basis and testing functions and the time step, the time marching scheme can be implicit (N. T. Gres, et al., Radio Sci., 36(3), 379-386, 2001) or explicit (A. Al-Jarro, et al., IEEE Trans. Antennas Propag., 60(11), 5203-5214, 2012). Implicit MOT schemes are known to be more stable and accurate. However, under low-frequency excitation, i.e., when the time step size is large, they call for inversion of a full matrix system at very time step.

An explicit marching on-in-time solver for the time domain volume magnetic field integral equation

KAUST Repository

Sayed, Sadeed Bin; Ulku, Huseyin Arda; Bagci, Hakan

2014-01-01

Transient scattering from inhomogeneous dielectric objects can be modeled using time domain volume integral equations (TDVIEs). TDVIEs are oftentimes solved using marching on-in-time (MOT) techniques. Classical MOT-TDVIE solvers expand the field induced on the scatterer using local spatio-temporal basis functions. Inserting this expansion into the TDVIE and testing the resulting equation in space and time yields a system of equations that is solved by time marching. Depending on the type of the basis and testing functions and the time step, the time marching scheme can be implicit (N. T. Gres, et al., Radio Sci., 36(3), 379-386, 2001) or explicit (A. Al-Jarro, et al., IEEE Trans. Antennas Propag., 60(11), 5203-5214, 2012). Implicit MOT schemes are known to be more stable and accurate. However, under low-frequency excitation, i.e., when the time step size is large, they call for inversion of a full matrix system at very time step.

Ghana Journal of Development Studies, Volume 7, Number 2

African Journals Online (AJOL)

UDS-CAPTURED

Ghana Journal of Development Studies, Volume 7, Number 2 2010. 53 ... The use of motorcycles for urban passenger transport in Nigeria popularly called okada is a source of ..... Gap in Mexico Washington, DC: The World Bank. Becker, S. G. ...

Determining volume sensitive waters in Beaufort County, SC tidal creeks

Science.gov (United States)

Andrew Tweel; Denise Sanger; Anne Blair; John Leffler

2016-01-01

Non-point source pollution from stormwater runoff associated with large-scale land use changes threatens the integrity of ecologically and economically valuable estuarine ecosystems. Beaufort County, SC implemented volume-based stormwater regulations on the rationale that if volume discharge is controlled, contaminant loading will also be controlled.

Customer Integration in Service Innovation: An Exploratory Study

Directory of Open Access Journals (Sweden)

Tim Straub

2013-09-01

Full Text Available Prominent industry projects, as well as an extensive literature suggest the importance of customer integration for companies’ innovation success. This appears to be especially true for service firms, which inherently build on customer interaction. Despite this appreciation of the approach, there are comparably few empirical analyses of the positive and negative effects of customer integration. In this exploratory study, we build on established customer role concepts to study the status quo of customer integration in industry, as well as reservations against the roles and negative experiences from customer integration projects. The study reveals a gap between reservations and actual negative experiences in losing know-how, as well as a positive effect of experience in customer integration on perceived benefits for the company.

Impact of institutional volume and experience with CT interpretation on sizing of transcatheter aortic valves: A multicenter retrospective study

Energy Technology Data Exchange (ETDEWEB)

Verma, Divya Ratan [Cardiovascular Institute, Banner University Medical Center, Phoenix, AZ (United States); Division of Interventional Cardiology, Banner University Medical Center, Phoenix, AZ (United States); Pershad, Yash [Department of Radiology, Banner University Medical Center, Phoenix, AZ (United States); Pershad, Ashish [Cardiovascular Institute, Banner University Medical Center, Phoenix, AZ (United States); Division of Interventional Cardiology, Banner University Medical Center, Phoenix, AZ (United States); Fang, Kenith [Cardiovascular Institute, Banner University Medical Center, Phoenix, AZ (United States); Division of Cardiothoracic Surgery, Banner University Medical Center, Phoenix, AZ (United States); Gellert, George [Cardiovascular Institute, Banner University Medical Center, Phoenix, AZ (United States); Department of Anesthesiology, Banner University Medical Center, Phoenix, AZ (United States); Morris, Michael F., E-mail: mfmorris@mail.arizona.edu [Cardiovascular Institute, Banner University Medical Center, Phoenix, AZ (United States); Department of Radiology, Banner University Medical Center, Phoenix, AZ (United States)

2016-12-15

Background: Computed tomography (CT) has become the standard imaging modality for pre-procedural aortic annular sizing prior to transcatheter aortic valve replacement (TAVR). We hypothesized that the accuracy of CT derived annular measurements would be greater at sites with higher TAVR procedural volume. Methods: Within a large integrated health system, TAVR was performed at low (<40 cases), intermediate (40–75 cases), and high-volume sites (>75 cases). 181 patients underwent TAVR with a Sapien XT transcatheter heart valve (THV). Two blinded experienced readers independently remeasured the annulus on CT and compared their measurements to site reported measurements. Hypothetical THV sizes were chosen based on measurements from site CT reports and independent readers’ measurements, and compared to the implanted THV size. Results: Correlation between site reported measurements and independent readers measurements of mean annulus size varied between low-volume (r = 0.31, p = 0.18), intermediate-volume (r = 0.34, p = 0.01), and high-volume sites (r = 0.96, p < 0.01). On multivariate analysis, interpretation of ≥20 CT scans (OR 0.29; 95% CI 0.03–0.81; p 0.02) and high-volume site (OR 0.16; 95% CI 0.10–0.82; p 0.02) were associated with reduced mismatch between the site predicted THV size and independent readers predicted THV size. Mismatch between site predicted THV size and implanted THV size was associated with a worse 30-day composite of mortality, dialysis-dependent renal failure, cerebrovascular accident, new permanent pacemaker, and hospital readmission (55.3 vs. 38.7%; p = 0.05). Conclusions: Accuracy of CT aortic annular sizing is improved with higher individual experience and site TAVR volume. These findings should be confirmed in larger, prospective studies. - Highlights: • Accuracy of CT aortic annular sizing is improved with higher individual experience and site TAVR volume. • CT readers with experience interpreting ≥20 pre-TAVR CT scans had

Novel genetic loci associated with hippocampal volume

NARCIS (Netherlands)

Hibar, Derrek P.; Adams, Hieab H. H.; Jahanshad, Neda; Chauhan, Ganesh; Stein, Jason L.; Hofer, Edith; Renteria, Miguel E.; Bis, Joshua C.; Arias-Vasquez, Alejandro; Ikram, M. Kamran; Desrivières, Sylvane; Vernooij, Meike W.; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf; Andersson, Micael; Arfanakis, Konstantinos; Aribisala, Benjamin S.; Armstrong, Nicola J.; Athanasiu, Lavinia; Axelsson, Tomas; Beecham, Ashley H.; Beiser, Alexa; Bernard, Manon; Blanton, Susan H.; Bohlken, Marc M.; Boks, Marco P.; Bralten, Janita; Brickman, Adam M.; Carmichael, Owen; Chakravarty, M. Mallar; Chen, Qiang; Ching, Christopher R. K.; Chouraki, Vincent; Cuellar-Partida, Gabriel; Crivello, Fabrice; den Braber, Anouk; Doan, Nhat Trung; Ehrlich, Stefan; Giddaluru, Sudheer; Goldman, Aaron L.; Gottesman, Rebecca F.; Grimm, Oliver; Griswold, Michael E.; Guadalupe, Tulio; Gutman, Boris A.; Hass, Johanna; Haukvik, Unn K.; Hoehn, David; Holmes, Avram J.; Hoogman, Martine; Janowitz, Deborah; Jia, Tianye; Jørgensen, Kjetil N.; Karbalai, Nazanin; Kasperaviciute, Dalia; Kim, Sungeun; Klein, Marieke; Kraemer, Bernd; Lee, Phil H.; Liewald, David C. M.; Lopez, Lorna M.; Luciano, Michelle; Macare, Christine; Marquand, Andre F.; Matarin, Mar; Mather, Karen A.; Mattheisen, Manuel; McKay, David R.; Milaneschi, Yuri; Muñoz Maniega, Susana; Nho, Kwangsik; Nugent, Allison C.; Nyquist, Paul; Loohuis, Loes M. Olde; Oosterlaan, Jaap; Papmeyer, Martina; Pirpamer, Lukas; Pütz, Benno; Ramasamy, Adaikalavan; Richards, Jennifer S.; Risacher, Shannon L.; Roiz-Santiañez, Roberto; Rommelse, Nanda; Ropele, Stefan; Rose, Emma J.; Royle, Natalie A.; Rundek, Tatjana; Sämann, Philipp G.; Saremi, Arvin; Satizabal, Claudia L.; Schmaal, Lianne; Schork, Andrew J.; Shen, Li; Shin, Jean; Shumskaya, Elena; Smith, Albert V.; Sprooten, Emma; Strike, Lachlan T.; Teumer, Alexander; Tordesillas-Gutierrez, Diana; Toro, Roberto; Trabzuni, Daniah; Trompet, Stella; Vaidya, Dhananjay; van der Grond, Jeroen; van der Lee, Sven J.; van der Meer, Dennis; van Donkelaar, Marjolein M. J.; van Eijk, Kristel R.; van Erp, Theo G. M.; van Rooij, Daan; Walton, Esther; Westlye, Lars T.; Whelan, Christopher D.; Windham, Beverly G.; Winkler, Anderson M.; Wittfeld, Katharina; Woldehawariat, Girma; Wolf, Christiane; Wolfers, Thomas; Yanek, Lisa R.; Yang, Jingyun; Zijdenbos, Alex; Zwiers, Marcel P.; Agartz, Ingrid; Almasy, Laura; Ames, David; Amouyel, Philippe; Andreassen, Ole A.; Arepalli, Sampath; Assareh, Amelia A.; Barral, Sandra; Bastin, Mark E.; Becker, Diane M.; Becker, James T.; Bennett, David A.; Blangero, John; van Bokhoven, Hans; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Brunner, Han G.; Buckner, Randy L.; Buitelaar, Jan K.; Bulayeva, Kazima B.; Cahn, Wiepke; Calhoun, Vince D.; Cannon, Dara M.; Cavalleri, Gianpiero L.; Cheng, Ching-Yu; Cichon, Sven; Cookson, Mark R.; Corvin, Aiden; Crespo-Facorro, Benedicto; Curran, Joanne E.; Czisch, Michael; Dale, Anders M.; Davies, Gareth E.; de Craen, Anton J. M.; de Geus, Eco J. C.; de Jager, Philip L.; de Zubicaray, Greig I.; Deary, Ian J.; Debette, Stéphanie; Decarli, Charles; Delanty, Norman; Depondt, Chantal; DeStefano, Anita; Dillman, Allissa; Djurovic, Srdjan; Donohoe, Gary; Drevets, Wayne C.; Duggirala, Ravi; Dyer, Thomas D.; Enzinger, Christian; Erk, Susanne; Espeseth, Thomas; Fedko, Iryna O.; Fernández, Guillén; Ferrucci, Luigi; Fisher, Simon E.; Fleischman, Debra A.; Ford, Ian; Fornage, Myriam; Foroud, Tatiana M.; Fox, Peter T.; Francks, Clyde; Fukunaga, Masaki; Gibbs, J. Raphael; Glahn, David C.; Gollub, Randy L.; Göring, Harald H. H.; Green, Robert C.; Gruber, Oliver; Gudnason, Vilmundur; Guelfi, Sebastian; Håberg, Asta K.; Hansell, Narelle K.; Hardy, John; Hartman, Catharina A.; Hashimoto, Ryota; Hegenscheid, Katrin; Heinz, Andreas; Le Hellard, Stephanie; Hernandez, Dena G.; Heslenfeld, Dirk J.; Ho, Beng-Choon; Hoekstra, Pieter J.; Hoffmann, Wolfgang; Hofman, Albert; Holsboer, Florian; Homuth, Georg; Hosten, Norbert; Hottenga, Jouke-Jan; Huentelman, Matthew; Pol, Hilleke E. Hulshoff; Ikeda, Masashi; Jack, Clifford R.; Jenkinson, Mark; Johnson, Robert; Jönsson, Erik G.; Jukema, J. Wouter; Kahn, René S.; Kanai, Ryota; Kloszewska, Iwona; Knopman, David S.; Kochunov, Peter; Kwok, John B.; Lawrie, Stephen M.; Lemaître, Hervé; Liu, Xinmin; Longo, Dan L.; Lopez, Oscar L.; Lovestone, Simon; Martinez, Oliver; Martinot, Jean-Luc; Mattay, Venkata S.; McDonald, Colm; McIntosh, Andrew M.; McMahon, Francis J.; McMahon, Katie L.; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Mohnke, Sebastian; Montgomery, Grant W.; Morris, Derek W.; Mosley, Thomas H.; Mühleisen, Thomas W.; Müller-Myhsok, Bertram; Nalls, Michael A.; Nauck, Matthias; Nichols, Thomas E.; Niessen, Wiro J.; Nöthen, Markus M.; Nyberg, Lars; Ohi, Kazutaka; Olvera, Rene L.; Ophoff, Roel A.; Pandolfo, Massimo; Paus, Tomas; Pausova, Zdenka; Penninx, Brenda W. J. H.; Pike, G. Bruce; Potkin, Steven G.; Psaty, Bruce M.; Reppermund, Simone; Rietschel, Marcella; Roffman, Joshua L.; Romanczuk-Seiferth, Nina; Rotter, Jerome I.; Ryten, Mina; Sacco, Ralph L.; Sachdev, Perminder S.; Saykin, Andrew J.; Schmidt, Reinhold; Schmidt, Helena; Schofield, Peter R.; Sigursson, Sigurdur; Simmons, Andrew; Singleton, Andrew; Sisodiya, Sanjay M.; Smith, Colin; Smoller, Jordan W.; Soininen, Hilkka; Steen, Vidar M.; Stott, David J.; Sussmann, Jessika E.; Thalamuthu, Anbupalam; Toga, Arthur W.; Traynor, Bryan J.; Troncoso, Juan; Tsolaki, Magda; Tzourio, Christophe; Uitterlinden, Andre G.; Hernández, Maria C. Valdés; van der Brug, Marcel; van der Lugt, Aad; van der Wee, Nic J. A.; van Haren, Neeltje E. M.; van 't Ent, Dennis; van Tol, Marie-Jose; Vardarajan, Badri N.; Vellas, Bruno; Veltman, Dick J.; Völzke, Henry; Walter, Henrik; Wardlaw, Joanna M.; Wassink, Thomas H.; Weale, Michael E.; Weinberger, Daniel R.; Weiner, Michael W.; Wen, Wei; Westman, Eric; White, Tonya; Wong, Tien Y.; Wright, Clinton B.; Zielke, Ronald H.; Zonderman, Alan B.; Martin, Nicholas G.; van Duijn, Cornelia M.; Wright, Margaret J.; Longstreth, W. T.; Schumann, Gunter; Grabe, Hans J.; Franke, Barbara; Launer, Lenore J.; Medland, Sarah E.; Seshadri, Sudha; Thompson, Paul M.; Ikram, M. Arfan

2017-01-01

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of

Vandenberg Air Force Base integrated resource assessment. Volume 3, Resource assessment

Energy Technology Data Exchange (ETDEWEB)

Daellenbach, K.K.; Dagle, J.E.; Dittmer, A.L.; Elliott, D.B.; Halverson, M.A.; Hickman, B.J.; Parker, G.B.; Richman, E.E.; Shankle, S.A.

1993-06-01

The US Air Force Space Command (SPACECOM) has tasked the Pacific Northwest Laboratory (PNL), as the lead laboratory supporting the US Department of Energy (DOE) Federal Energy Management Program (FEMP), to identify, evaluate, and assist in acquiring all cost-effective energy projects at Vandenberg Air Force Base (VAFB). This is part of a model program that PNL is designing to support energy-use decisions in the federal sector. This report provides the results of the fossil fuel and electric energy resource opportunity (ERO) assessments performed by PNL at the SPACECOM VAFB facility located approximately 50 miles northwest of Santa Barbara, California. It is a companion report to Volume 1, Executive Summary, and Volume 2, Baseline Detail. The results of the analysis of EROs are presented in ten common energy end-use categories (e.g., boilers and furnaces, service hot water, and building lighting). In addition, a case study of process loads at Space Launch Complex-4 (SLC-4) is included. A narrative description of each ERO is provided, including information on the installed cost, energy and dollar savings; impacts on operation and maintenance (O and M); and, when applicable, a discussion of energy supply and demand, energy security, and environmental issues. A description of the evaluation methodologies and technical and cost assumptions is also provided for each ERO. Summary tables present the cost-effectiveness of energy end-use equipment before and after the implementation of each ERO and present the results of the life-cycle cost (LCC) analysis indicating the net present value (NPV) and value index (VI) of each ERO. Finally, an appendix includes a summary of an economic analysis case study of the South Vandenberg Power Plant (SVPP) operating scenarios.

Satellite Power Systems (SPS) concept definition study. Volume 6: SPS technology requirements and verification

Science.gov (United States)

Hanley, G.

1978-01-01

Volume 6 of the SPS Concept Definition Study is presented and also incorporates results of NASA/MSFC in-house effort. This volume includes a supporting research and technology summary. Other volumes of the final report that provide additional detail are as follows: (1) Executive Summary; (2) SPS System Requirements; (3) SPS Concept Evolution; (4) SPS Point Design Definition; (5) Transportation and Operations Analysis; and Volume 7, SPS Program Plan and Economic Analysis.

Resonance integral of cylindrical absorber; Rezonantni integral cilindricnog absorbera

Energy Technology Data Exchange (ETDEWEB)

Slipicevic, K [Elektrotehnicki fakultet, Belgrade (Yugoslavia)

1968-07-01

This paper presents the procedure for calculating effective resonance integral for cylindrical rod which enables derivation of improved spatial distribution of source neutron flux. Application of this new expression for penetration factor, simultaneously with Doppler broadening of Breight-Wigner line enabled derivation of new equation for resonance integral which is valid for the whole range of surface-volume ratio of the rod, has correct boundary conditions and gives as special, results same as Wigner and Pomeranchuk. Functions for correcting the effects of interference of potential and resonance dissipation are derived separately.

Delivery of tidal volume from four anaesthesia ventilators during volume-controlled ventilation: a bench study.

Science.gov (United States)

Wallon, G; Bonnet, A; Guérin, C

2013-06-01

Tidal volume (V(T)) must be accurately delivered by anaesthesia ventilators in the volume-controlled ventilation mode in order for lung protective ventilation to be effective. However, the impact of fresh gas flow (FGF) and lung mechanics on delivery of V(T) by the newest anaesthesia ventilators has not been reported. We measured delivered V(T) (V(TI)) from four anaesthesia ventilators (Aisys™, Flow-i™, Primus™, and Zeus™) on a pneumatic test lung set with three combinations of lung compliance (C, ml cm H2O(-1)) and resistance (R, cm H2O litre(-1) s(-2)): C60R5, C30R5, C60R20. For each CR, three FGF rates (0.5, 3, 10 litre min(-1)) were investigated at three set V(T)s (300, 500, 800 ml) and two values of PEEP (0 and 10 cm H2O). The volume error = [(V(TI) - V(Tset))/V(Tset)] ×100 was computed in body temperature and pressure-saturated conditions and compared using analysis of variance. For each CR and each set V(T), the absolute value of the volume error significantly declined from Aisys™ to Flow-i™, Zeus™, and Primus™. For C60R5, these values were 12.5% for Aisys™, 5% for Flow-i™ and Zeus™, and 0% for Primus™. With an increase in FGF, absolute values of the volume error increased only for Aisys™ and Zeus™. However, in C30R5, the volume error was minimal at mid-FGF for Aisys™. The results were similar at PEEP 10 cm H2O. Under experimental conditions, the volume error differed significantly between the four new anaesthesia ventilators tested and was influenced by FGF, although this effect may not be clinically relevant.

The development of a volume element model for energy systems engineering and integrative thermodynamic optimization

Science.gov (United States)

Yang, Sam

The dissertation presents the mathematical formulation, experimental validation, and application of a volume element model (VEM) devised for modeling, simulation, and optimization of energy systems in their early design stages. The proposed model combines existing modeling techniques and experimental adjustment to formulate a reduced-order model, while retaining sufficient accuracy to serve as a practical system-level design analysis and optimization tool. In the VEM, the physical domain under consideration is discretized in space using lumped hexahedral elements (i.e., volume elements), and the governing equations for the variable of interest are applied to each element to quantify diverse types of flows that cross it. Subsequently, a system of algebraic and ordinary differential equations is solved with respect to time and scalar (e.g., temperature, relative humidity, etc.) fields are obtained in both spatial and temporal domains. The VEM is capable of capturing and predicting dynamic physical behaviors in the entire system domain (i.e., at system level), including mutual interactions among system constituents, as well as with their respective surroundings and cooling systems, if any. The VEM is also generalizable; that is, the model can be easily adapted to simulate and optimize diverse systems of different scales and complexity and attain numerical convergence with sufficient accuracy. Both the capability and generalizability of the VEM are demonstrated in the dissertation via thermal modeling and simulation of an Off-Grid Zero Emissions Building, an all-electric ship, and a vapor compression refrigeration (VCR) system. Furthermore, the potential of the VEM as an optimization tool is presented through the integrative thermodynamic optimization of a VCR system, whose results are used to evaluate the trade-offs between various objective functions, namely, coefficient of performance, second law efficiency, pull-down time, and refrigerated space temperature, in

Cross-correlations in volume space: Differences between buy and sell volumes

Science.gov (United States)

Lee, Sun Young; Hwang, Dong Il; Kim, Min Jae; Koh, In Gyu; Kim, Soo Yong

2011-03-01

We study the cross-correlations of buy and sell volumes on the Korean stock market in high frequency. We observe that the pulling effects of volumes are as small as that of returns. The properties of the correlations of buy and sell volumes differ. They are explained by the degree of synchronization of stock volumes. Further, the pulling effects on the minimal spanning tree are studied. In minimal spanning trees with directed links, the large pulling effects are clustered at the center, not uniformly distributed. The Epps effect of buy and sell volumes are observed. The reversal of the cross-correlations of buy and sell volumes is also detected.

The study of alteration in left ventricular volume and pressure to volume ratio during exercise in patients with coronary heart disease

International Nuclear Information System (INIS)

Liu Zhonglin; Pei Zhuguo; Zang Bin

1994-01-01

The alterations induced by exercise in left ventricular end diastolic volume index (EDVI), end systolic volume index (ESVI) and systolic blood pressure to end systolic volume ratio (P/ESV) were studied in 15 normal subjects and 42 patients with coronary heart disease using a non-geometric count-based method and supine bicycle exercise test. Normal subjects had an increase in EDVI and a decrease in ESVI, but coronary heart disease patients had an increase in both EDVI and ESVI. The extent of increase induced by exercise in EDVI was greater in angina patients than that in normal and old myocardial infarction subjects. The P/ESV can be used to evaluate left ventricular systolic pressure-volume relationship. For the P/ESV exercise response, the sensitivity, specificity and accuracy for coronary heart disease were 95%, 93% and 95%, respectively

An integrated logistic formula for prediction of complications from radiosurgery

International Nuclear Information System (INIS)

Flickinger, J.C.

1989-01-01

An integrated logistic model for predicting the probability of complications when small volumes of tissue receive an inhomogeneous radiation dose is described. This model can be used with either an exponential or linear quadratic correction for dose per fraction and time. Both the exponential and linear quadratic versions of this integrated logistic formula provide reasonable estimates of the tolerance of brain to radiosurgical dose distributions where there are small volumes of brain receiving high radiation doses and larger volumes receiving lower doses. This makes it possible to predict the probability of complications from stereotactic radiosurgery, as well as combinations of fractionated large volume irradiation with a radiosurgical boost. Complication probabilities predicted for single fraction radiosurgery with the Leksell Gamma Unit using 4, 8, 14, and 18 mm diameter collimators as well as for whole brain irradiation combined with a radiosurgical boost are presented. The exponential and linear quadratic versions of the integrated logistic formula provide useful methods of calculating the probability of complications from radiosurgical treatment

Functional integration over geometries

International Nuclear Information System (INIS)

Mottola, E.

1995-01-01

The geometric construction of the functional integral over coset spaces M/G is reviewed. The inner product on the cotangent space of infinitesimal deformations of M defines an invariant distance and volume form, or functional integration measure on the full configuration space. Then, by a simple change of coordinates parameterizing the gauge fiber G, the functional measure on the coset space M/G is deduced. This change of integration variables leads to a Jacobian which is entirely equivalent to the Faddeev--Popov determinant of the more traditional gauge fixed approach in non-abelian gauge theory. If the general construction is applied to the case where G is the group of coordinate reparameterizations of spacetime, the continuum functional integral over geometries, i.e. metrics modulo coordinate reparameterizations may be defined. The invariant functional integration measure is used to derive the trace anomaly and effective action for the conformal part of the metric in two and four dimensional spacetime. In two dimensions this approach generates the Polyakov--Liouville action of closed bosonic non-critical string theory. In four dimensions the corresponding effective action leads to novel conclusions on the importance of quantum effects in gravity in the far infrared, and in particular, a dramatic modification of the classical Einstein theory at cosmological distance scales, signaled first by the quantum instability of classical de Sitter spacetime. Finite volume scaling relations for the functional integral of quantum gravity in two and four dimensions are derived, and comparison with the discretized dynamical triangulation approach to the integration over geometries are discussed. Outstanding unsolved problems in both the continuum definition and the simplicial approach to the functional integral over geometries are highlighted

Benefit-Cost Analysis of Integrated Paratransit Systems : Volume 6. Technical Appendices.

Science.gov (United States)

1979-09-01

This last volume, includes five technical appendices which document the methodologies used in the benefit-cost analysis. They are the following: Scenario analysis methodology; Impact estimation; Example of impact estimation; Sensitivity analysis; Agg...

Importance of the test volume on the lag phase in biodegradation studies

DEFF Research Database (Denmark)

Ingerslev, F.; Torang, Lars; Nyholm, Niels

2000-01-01

, degradation failed randomly. Our findings are partly explained by the hypotheses that a sufficient total amount as well as a sufficient concentration of specifically degrading microorganisms or consortia of bacteria must be present initially for biodegradation to get started, from which follows that with too......Increasing the total volume of test medium resulted in decreased lag times (TL) in biodegradability shake flask batch tests conducted with either surface water or with synthetic mineral medium inoculated with supernatant from settled activated sludge. Experiments were performed with test volumes...... small inoculations or with too small test volumes, biodegradation may fail randomly. A straightforward practical implication of the findings is that the test volume in biodegradability tests can significantly influence the lag time and thus sometimes be decisive for the outcome in biodegradation studies....

Multiloop integral system test (MIST): Final report, Inter-group comparisons

Energy Technology Data Exchange (ETDEWEB)

Gloudemans, J.R.

1989-07-01

The multiloop integral system test (MIST) was part of a multiphase program started in 1983 to address small-break loss-of-coolant accidents (SBLOCAs) specific to Babcock and Wilcox-designed plants. MIST was sponsored by the US Nuclear Regulatory Commission, the Babcock and Wilcox Owners Group, the Electric Power Research Institute, and Babcock and Wilcox. The unique features of the Babcock and Wilcox design, specifically the hot leg U-bends and steam generators, prevented the use of existing integral system data or existing integral system facilities to address the thermal-hydraulic SBLOCA questions. MIST and two other supporting facilities were specifically designed and constructed for this program, and an existing facility -- the once-through integral system (OTIS) -- was also used. Data from MIST and the other facilities will be used to benchmark the adequacy of system codes, such as RELAP5 and TRAC, for predicting abnormal plant transients. The individual tests are described in detail in Volumes 2 through 8 and Volume 11, and are summarized in Volume 1. Inter-group comparisons are addressed in this document, Volume 9. These comparisons are grouped as follows: mapping versus SBLOCA transients, SBLOCA, pump effects, and the effects of noncondensible gases. Appendix A provides an index and description of the microfiched plots for each test, which are enclosed with the corresponding Volumes 2 through 8. 147 figs., 5 tabs.

Anatomic relationships of the distal and proximal radioulnar joints articulating surface areas, and of the radius and ulna bone volumes – implications for biomechanical studies of the distal and proximal radioulnar joints and forearm bones

Directory of Open Access Journals (Sweden)

Paul S C Malone

2016-07-01

Full Text Available BackgroundPrevious work from this laboratory has evidenced the biomechanical role of forearm osseoligamentous structures in load transfer of applied forces. It has shown that transmitted forces across the distal radioulnar joint (DRUJ and proximal radioulnar joint (PRUJ are similar though not identical under axial loading conditions. The purpose of the study was to assess the articulating surface areas of the radioulnar joints and the volumes of the forearm bones addressing the hypothesis that there may be anatomic adaptations that reflect the biomechanical function of the integrated forearm unit.MethodsThe articulating surface areas of PRUJ and DRUJ were assessed using a laser scanner in 24 cadaver forearms. The articulating joint surfaces were additionally delineated from standardized photographs assessed by three observers. The surface areas of matched pairs of joints were compared on the null hypothesis that these were the same within a given forearm specimen. An additional 44 pairs of matched forearm bone volumes were measured using water displacement technique and again compared through statistical analysis (paired sample t-test, and Bland Altman analysis.ResultsThe findings of this study are that the articulating surface areas of the DRUJ and PRUJ as well as the bone volumes are significantly different and yet strongly correlated. The paired sample t-test showed a significant difference between the surface areas of the DRUJ and PRUJ (p<0.05. The PRUJ articulating surface area was marginally larger than the DRUJ with a PRUJ : DRUJ ratio of 1.02. Paired sample t-test showed a significant difference between the two bone volumes (p<0.01 with a radius to ulna bone volume ratio of 0.81. When the olecranon was disregarded, radius volume was on average 4% greater than ulna volume.ConclusionsThis study demonstrated defines the anatomical relationships between the two forearm bones and their articulating joints when matched for specimen. The data

Control volume based hydrocephalus research; analysis of human data

Science.gov (United States)

Cohen, Benjamin; Wei, Timothy; Voorhees, Abram; Madsen, Joseph; Anor, Tomer

2010-11-01

Hydrocephalus is a neuropathophysiological disorder primarily diagnosed by increased cerebrospinal fluid volume and pressure within the brain. To date, utilization of clinical measurements have been limited to understanding of the relative amplitude and timing of flow, volume and pressure waveforms; qualitative approaches without a clear framework for meaningful quantitative comparison. Pressure volume models and electric circuit analogs enforce volume conservation principles in terms of pressure. Control volume analysis, through the integral mass and momentum conservation equations, ensures that pressure and volume are accounted for using first principles fluid physics. This approach is able to directly incorporate the diverse measurements obtained by clinicians into a simple, direct and robust mechanics based framework. Clinical data obtained for analysis are discussed along with data processing techniques used to extract terms in the conservation equation. Control volume analysis provides a non-invasive, physics-based approach to extracting pressure information from magnetic resonance velocity data that cannot be measured directly by pressure instrumentation.

Temporal, seasonal and weather effects on cycle volume: an ecological study

Directory of Open Access Journals (Sweden)

Tin Tin Sandar

2012-03-01

Full Text Available Abstract Background Cycling has the potential to provide health, environmental and economic benefits but the level of cycling is very low in New Zealand and many other countries. Adverse weather is often cited as a reason why people do not cycle. This study investigated temporal and seasonal variability in cycle volume and its association with weather in Auckland, New Zealand's largest city. Methods Two datasets were used: automated cycle count data collected on Tamaki Drive in Auckland by using ZELT Inductive Loop Eco-counters and weather data (gust speed, rain, temperature, sunshine duration available online from the National Climate Database. Analyses were undertaken using data collected over one year (1 January to 31 December 2009. Normalised cycle volumes were used in correlation and regression analyses to accommodate differences by hour of the day and day of the week and holiday. Results In 2009, 220,043 bicycles were recorded at the site. There were significant differences in mean hourly cycle volumes by hour of the day, day type and month of the year (p p Conclusions There are temporal and seasonal variations in cycle volume in Auckland and weather significantly influences hour-to-hour and day-to-day variations in cycle volume. Our findings will help inform future cycling promotion activities in Auckland.

Advances in Serials Management. Volume 6.

Science.gov (United States)

Hepfer, Cindy, Ed.; Gammon, Julia, Ed.; Malinowski, Teresa, Ed.

In order to further discussion and support constructive change, this volume presents the following eight papers on various dimensions of serials management: (1) "CD-ROMs, Surveys, and Sales: The OSA [Optical Society of America] Experience" (Frank E. Harris and Alan Tourtlotte); (2) "Management and Integration of Electronic Journals into the…

Scoping studies to reduce ICPP high-level radioactive waste volumes for final disposal

International Nuclear Information System (INIS)

Knecht, D.A.; Berreth, J.R.; Chipman, N.A.; Cole, H.S.; Geczi, L.S.; Kerr, W.B.; Staples, B.A.

1985-08-01

This report presents the results of scoping studies carried out to determine the feasibility of the following candidate options to reduce high-level waste volume: (1) low-fluoride, low-volume glass, (2) glass-ceramic and ceramic, (3) Modified Zirflex, (4) inerts removal by neutralization, and (5) modified Fluorinel processes. The results of the scoping studies show that the glass-ceramic/ceramic waste forms and neutralization process with potential HLW volume reductions ranging from 60 to 80% appear feasible, based on laboratory-scale tests. The presently used Fluorinel process modified by reducing HF usage also appears to be feasible and could result in up to a 10% potential volume reduction. If the current process start-up tests verify the practicality, reduced HF usage will be implemented. The low-volume glass and Modified Zirflex processes may also be feasible, based on laboratory tests, but would require significantly more process development and/or modifications and could result in only a 20 to 30% potential volume reduction. Based on these scoping studies, it is recommended that (1) the glass-ceramic/ceramic and neutralization processes be developed further, (2) reduced HF use for the Modified Fluorinel process be implemented as soon as practical and other options reducing chemical usage for criticality control be evaluated, (3) basic development for the glass process be continued as a back-up technology, and (4) laboratory-scale radioactive fuel dissolution testing for the Modified Zirflex process be completed with further process development discontinued unless needed in the future

Intraday Analysis of Market Integration: Dutch Blue Chips traded in Amsterdam and New York

NARCIS (Netherlands)

A.J. Menkveld (Bert)

2000-01-01

textabstractMarket integration is studied for Dutch stocks cross-listed at the NYSE. Trading starts in Amsterdam and ends in New York with a one-hour overlap. Both markets are not perfectly integrated in that they can be viewed as one market with the well-documented U-shape in volatility, volume and

Kirkwood-Buff integrals of finite systems: shape effects

Science.gov (United States)

Dawass, Noura; Krüger, Peter; Simon, Jean-Marc; Vlugt, Thijs J. H.

2018-06-01

The Kirkwood-Buff (KB) theory provides an important connection between microscopic density fluctuations in liquids and macroscopic properties. Recently, Krüger et al. derived equations for KB integrals for finite subvolumes embedded in a reservoir. Using molecular simulation of finite systems, KB integrals can be computed either from density fluctuations inside such subvolumes, or from integrals of radial distribution functions (RDFs). Here, based on the second approach, we establish a framework to compute KB integrals for subvolumes with arbitrary convex shapes. This requires a geometric function w(x) which depends on the shape of the subvolume, and the relative position inside the subvolume. We present a numerical method to compute w(x) based on Umbrella Sampling Monte Carlo (MC). We compute KB integrals of a liquid with a model RDF for subvolumes with different shapes. KB integrals approach the thermodynamic limit in the same way: for sufficiently large volumes, KB integrals are a linear function of area over volume, which is independent of the shape of the subvolume.

An integrated algorithm for hypersonic fluid-thermal-structural numerical simulation

Science.gov (United States)

Li, Jia-Wei; Wang, Jiang-Feng

2018-05-01

In this paper, a fluid-structural-thermal integrated method is presented based on finite volume method. A unified integral equations system is developed as the control equations for physical process of aero-heating and structural heat transfer. The whole physical field is discretized by using an up-wind finite volume method. To demonstrate its capability, the numerical simulation of Mach 6.47 flow over stainless steel cylinder shows a good agreement with measured values, and this method dynamically simulates the objective physical processes. Thus, the integrated algorithm proves to be efficient and reliable.

Radwaste '86: proceedings volume

International Nuclear Information System (INIS)

Ainslie, L.C.

1986-12-01

The volume contains all the papers presented at the above Conference, which was held in Cape Town, South Africa from 7 to 12 September 1986. A total of 55 contributions cover the full spectrum of the theme of the Conference, which was subdivided into four sessions. Conditioning, treatment and management of radioactive waste: 12 papers reporting on experiences in various countries, as well as specialist topics such as the extraction of radioactive contaminants from reactor pool water. Containment, safe handling and long-term integrity of ILLW packages: 2 papers dealing with cask design. Transport and storage of radwaste and spent fuel: 7 papers ranging from broad overviews to specific operations in different parts of the world. Radioactive waste disposal and environmental impact: 32 papers covering topics from site selection, design and operation, to modelling and monitoring studies. South Africa's Vaalputs radioactive waste disposal facility is comprehensively described. The volume is a useful reference for anyone interested in the disposal of radioactive waste, especially in arid environments, as well as its treatment and management prior to disposal, and will appeal to a wide range of disciplines including engineers, geologists, geophysicists, life scientists and environmentalists. Of particular interest would be the intensive studies undertaken in South Africa prior to the establishment of a radioactive waste repository in that country

North American Natural Gas Markets: Selected technical studies. Volume 3

Energy Technology Data Exchange (ETDEWEB)

Huntington, H.G.; Schuler, G.E. [eds.

1989-04-01

The Energy Modeling Forum (EMF) was established in 1976 at Stanford University to provide a structural framework within which energy experts, analysts, and policymakers could meet to improve their understanding of critical energy problems. The ninth EMF study, North American Natural Gas Markets, was conducted by a working group comprised of leading natural gas analysts and decision-makers from government, private companies, universities, and research and consulting organizations. The EMF 9 working group met five times from October 1986 through June 1988 to discuss key issues and analyze natural gas markets. This third volume includes technical papers that support many of the conclusions discussed in the EMF 9 summary report (Volume 1) and full working group report (Volume 2). These papers discuss the results from the individual models as well as some nonmodeling analysis related to US natural gas imports and industrial natural gas demand. Individual papers have been processed separately for inclusion in the Energy Science and Technology Database.

Volume measurement study for large scale input accountancy tank

International Nuclear Information System (INIS)

Uchikoshi, Seiji; Watanabe, Yuichi; Tsujino, Takeshi

1999-01-01

Large Scale Tank Calibration (LASTAC) facility, including an experimental tank which has the same volume and structure as the input accountancy tank of Rokkasho Reprocessing Plant (RRP) was constructed in Nuclear Material Control Center of Japan. Demonstration experiments have been carried out to evaluate a precision of solution volume measurement and to establish the procedure of highly accurate pressure measurement for a large scale tank with dip-tube bubbler probe system to be applied to the input accountancy tank of RRP. Solution volume in a tank is determined from substitution the solution level for the calibration function obtained in advance, which express a relation between the solution level and its volume in the tank. Therefore, precise solution volume measurement needs a precise calibration function that is determined carefully. The LASTAC calibration experiments using pure water showed good result in reproducibility. (J.P.N.)

Volume growth trends in a Douglas-fir levels-of-growing-stock study.

Science.gov (United States)

Robert O. Curtis

2006-01-01

Mean curves of increment and yield in gross total cubic volume and net merchantable cubic volume were derived from seven installations of the regional cooperative Levels-of-Growing-Stock Study (LOGS) in Douglas-fir. The technique used reduces the seven curves for each treatment for each variable of interest to a single set of readily interpretable mean curves. To a top...

Channeling, volume reflection, and volume capture study of electrons in a bent silicon crystal

Directory of Open Access Journals (Sweden)

T. N. Wistisen

2016-07-01

Full Text Available We present the experimental data and analysis of experiments conducted at SLAC National Accelerator Laboratory investigating the processes of channeling, volume-reflection and volume-capture along the (111 plane in a strongly bent quasimosaic silicon crystal. These phenomena were investigated at 5 energies: 3.35, 4.2, 6.3, 10.5, and 14.0 GeV with a crystal with bending radius of 0.15 m, corresponding to curvatures of 0.053, 0.066, 0.099, 0.16, and 0.22 times the critical curvature, respectively. Based on the parameters of fitting functions we have extracted important parameters describing the channeling process such as the dechanneling length, the angle of volume reflection, the surface transmission, and the widths of the distribution of channeled particles parallel and orthogonal to the plane.

Solid Waste Integrated Forecast Technical (SWIFT) Report FY 2001 to FY 2046 Volume 2

International Nuclear Information System (INIS)

BARCOT, R.A.

2001-01-01

The SWIFT Report provides up-to-date life cycle information about the radioactive solid waste expected to be managed by Hanford's Waste Management (WM) Project from onsite and offsite generators. This report is a mid-year update to the SWIFT 2001.0 report that was published in August 2000. The data contained in this report is the official data for solid waste forecasting until the SWIFT 2002.0 data is published in August 2001. This particular volume provides the following data reports: Annual volume data by waste generator; Summary volume data by location and DOE Office; Annual container type data by volume and count; and Annual physical waste form and waste specification record volume. This report also includes several minor changes from previous versions in an effort to increase the usability of the data and align with current Hanford Site organization changes. The changes include: Minor changes to waste generator names to make them more recognizable; Grouping of the waste generators into DOE Office and location (e.g, Office of River Protection, Fluor Hanford, Bechtel, etc); Addition of WSRd and Container Count sections; and Elimination of the ''functional group'' organization of the data (e.g., Facilities Transition, Spent Nuclear Fuel, etc)

Study of liver volume measurement and its clinical application for liver transplantation using multiple-slice spiral CT

International Nuclear Information System (INIS)

Peng Zhiyi; Yu Zhefeng; Kuang Pingding; Xiao Shengxiang; Huang Dongsheng; Zheng Shusen; Wu Jian

2004-01-01

Objective: To study the accuracy of liver volume measurement using MSCT and its application in liver transplantation. Methods: (1) Experimental study. Ten pig livers were scanned using MSCT with two collimations (3.2 mm and 6.5 mm) and pitch 1.25. Semi-automatic method was used to reconstruct 3D liver models to measure the liver volume. (2) Clinical study. Twenty-three patients received MSCT scan with collimation of 6.5 mm before liver transplantation. Same method was used to calculate the liver volume and the measurement was repeated by the same observer after 1 month. Results: (1) Experimental study. Actual liver volumes were (1134.1 ± 288.0) ml. Liver volumes by MSCT with two collimations were (1125.0 ± 282.5) ml (3.2 mm) and (1101.6 ± 277.6) ml (6.5 mm). The accuracy was (99.5 ± 0.8)% and (97.4 ± 0.8)%, respectively. Both showed same good agreement with actual liver volume: r=0.999, P<0.01 (2) Clinical study. Actual liver volumes were (1455.7±730.0) ml. Liver volume by MSCT was (1462.7 ± 774.1) ml. The accuracy was (99.5±9.6)%, r=0.986, P<0.01. Liver volume measured again was (1449.4 ± 768.9) ml, r=0.991 (P<0.01). Conclusion: MSCT can assess the liver volume correctly, and could be used as a routine step for evaluations before liver transplantation

Step-and-Shoot versus Compensator-based IMRT: Calculation and Comparison of Integral Dose in Non-tumoral and Target Organs in Prostate Cancer

Directory of Open Access Journals (Sweden)

Kaveh Shirani Tak Abi

2015-05-01

Full Text Available Introduction Intensity-Modulated Radiotherapy (IMRT is becoming an increasingly routine treatment method. IMRT can be delivered by use of conventional Multileaf Collimators (MLCs and/or physical compensators. One of the most important factors in selecting an appropriate IMRT technique is integral dose. Integral dose is equal to the mean energy deposited in the total irradiated volume of the patient. The aim of the present study was to calculate and compare the integral dose in normal and target organs in two different procedures of IMRT: Step-and-Shoot (SAS and compensator-based IMRT. Materials and Methods In this comparative study, five patients with prostate cancer were selected. Module Integrated Radiotherapy System was applied, using three energy ranges. In both treatment planning methods, the integral dose dramatically decreased by increasing energy. Results Comparison of two treatment methods showed that on average, the integral dose of body in SAS radiation therapy was about 1.62% lower than that reported in compensator-based IMRT. In planning target volume, rectum, bladder, and left and right femoral heads, the integral doses for SAS method were 1.01%, 1.02%, 1.11%, 1.47%, and 1.40% lower than compensator-based IMRT, respectively. Conclusion Considering the treatment conditions, the definition of dose volume constraints for healthy tissues, and the equal volume of organs in both treatment methods, SAS radiation therapy by providing a lower integral dose seems to be more advantageous and efficient for prostate cancer treatment, compared to compensator-based IMRT.

Parallel PWTD-Accelerated Explicit Solution of the Time Domain Electric Field Volume Integral Equation

KAUST Repository

Liu, Yang

2016-03-25

A parallel plane-wave time-domain (PWTD)-accelerated explicit marching-on-in-time (MOT) scheme for solving the time domain electric field volume integral equation (TD-EFVIE) is presented. The proposed scheme leverages pulse functions and Lagrange polynomials to spatially and temporally discretize the electric flux density induced throughout the scatterers, and a finite difference scheme to compute the electric fields from the Hertz electric vector potentials radiated by the flux density. The flux density is explicitly updated during time marching by a predictor-corrector (PC) scheme and the vector potentials are efficiently computed by a scalar PWTD scheme. The memory requirement and computational complexity of the resulting explicit PWTD-PC-EFVIE solver scale as ( log ) s s O N N and ( ) s t O N N , respectively. Here, s N is the number of spatial basis functions and t N is the number of time steps. A scalable parallelization of the proposed MOT scheme on distributed- memory CPU clusters is described. The efficiency, accuracy, and applicability of the resulting (parallelized) PWTD-PC-EFVIE solver are demonstrated via its application to the analysis of transient electromagnetic wave interactions on canonical and real-life scatterers represented with up to 25 million spatial discretization elements.

Parallel PWTD-Accelerated Explicit Solution of the Time Domain Electric Field Volume Integral Equation

KAUST Repository

Liu, Yang; Al-Jarro, Ahmed; Bagci, Hakan; Michielssen, Eric

2016-01-01

A parallel plane-wave time-domain (PWTD)-accelerated explicit marching-on-in-time (MOT) scheme for solving the time domain electric field volume integral equation (TD-EFVIE) is presented. The proposed scheme leverages pulse functions and Lagrange polynomials to spatially and temporally discretize the electric flux density induced throughout the scatterers, and a finite difference scheme to compute the electric fields from the Hertz electric vector potentials radiated by the flux density. The flux density is explicitly updated during time marching by a predictor-corrector (PC) scheme and the vector potentials are efficiently computed by a scalar PWTD scheme. The memory requirement and computational complexity of the resulting explicit PWTD-PC-EFVIE solver scale as ( log ) s s O N N and ( ) s t O N N , respectively. Here, s N is the number of spatial basis functions and t N is the number of time steps. A scalable parallelization of the proposed MOT scheme on distributed- memory CPU clusters is described. The efficiency, accuracy, and applicability of the resulting (parallelized) PWTD-PC-EFVIE solver are demonstrated via its application to the analysis of transient electromagnetic wave interactions on canonical and real-life scatterers represented with up to 25 million spatial discretization elements.

Spider phobia is associated with decreased left amygdala volume: a cross-sectional study

Science.gov (United States)

2013-01-01

Background Evidence from animal and human studies imply the amygdala as the most critical structure involved in processing of fear-relevant stimuli. In phobias, the amygdala seems to play a crucial role in the pathogenesis and maintenance of the disorder. However, the neuropathology of specific phobias remains poorly understood. In the present study, we investigated whether patients with spider phobia show altered amygdala volumes as compared to healthy control subjects. Methods Twenty female patients with spider phobia and twenty age-matched healthy female controls underwent magnetic resonance imaging to investigate amygdala volumes. The amygdalae were segmented using an automatic, model-based segmentation tool (FSL FIRST). Differences in amygdala volume were investigated by multivariate analysis of covariance with group as between-subject factor and left and right amygdala as dependent factors. The relation between amygdala volume and clinical features such as symptom severity, disgust sensitivity, trait anxiety and duration of illness was investigated by Spearman correlation analysis. Results Spider phobic patients showed significantly smaller left amygdala volume than healthy controls. No significant difference in right amygdala volume was detected. Furthermore, the diminished amygdala size in patients was related to higher symptom severity, but not to higher disgust sensitivity or trait anxiety and was independent of age. Conclusions In summary, the results reveal a relation between higher symptom severity and smaller left amygdala volume in patients with spider phobia. This relation was independent of other potential confounders such as the disgust sensitivity or trait anxiety. The findings suggest that greater spider phobic fear is associated with smaller left amygdala. However, the smaller left amygdala volume may either stand for a higher vulnerability to develop a phobic disorder or emerge as a consequence of the disorder. PMID:23442196

A comparative study of self-consolidating concretes incorporating high-volume natural pozzolan or high-volume fly ash

KAUST Repository

Celik, Kemal; Meral, Cagla; Mancio, Mauricio; Mehta, P. Kumar; Monteiro, Paulo J.M.

2014-01-01

The purpose of this study is to compare the effects of Portland cement replacement on the strength and durability of self-consolidating concretes (SSC). The two replacement materials used are high-volume natural pozzolan (HVNP), a Saudi Arabian aluminum-silica rich basaltic glass and high-volume Class-F fly ash (HVFAF), from Jim Bridger Power Plant, Wyoming, US. As an extension of the study, limestone filler (LF) is also used to replace Portland cement, alongside HVNP or HVFAF, forming ternary blends. Along with compressive strength tests, non-steady state chloride migration and gas permeability tests were performed, as durability indicators, on SCC specimens. The results were compared to two reference concretes; 100% ordinary Portland cement (OPC) and 85% OPC - 15% LF by mass. The HVNP and HVFAF concrete mixes showed strength and durability results comparable to those of the reference concretes; identifying that both can effectively be used to produce low-cost and environmental friendly SCC. © 2013 Elsevier Ltd. All rights reserved.

A comparative study of self-consolidating concretes incorporating high-volume natural pozzolan or high-volume fly ash

KAUST Repository

Celik, Kemal

2014-09-01

The purpose of this study is to compare the effects of Portland cement replacement on the strength and durability of self-consolidating concretes (SSC). The two replacement materials used are high-volume natural pozzolan (HVNP), a Saudi Arabian aluminum-silica rich basaltic glass and high-volume Class-F fly ash (HVFAF), from Jim Bridger Power Plant, Wyoming, US. As an extension of the study, limestone filler (LF) is also used to replace Portland cement, alongside HVNP or HVFAF, forming ternary blends. Along with compressive strength tests, non-steady state chloride migration and gas permeability tests were performed, as durability indicators, on SCC specimens. The results were compared to two reference concretes; 100% ordinary Portland cement (OPC) and 85% OPC - 15% LF by mass. The HVNP and HVFAF concrete mixes showed strength and durability results comparable to those of the reference concretes; identifying that both can effectively be used to produce low-cost and environmental friendly SCC. © 2013 Elsevier Ltd. All rights reserved.

Combined low-volume polyethylene glycol solution plus stimulant laxatives versus standard-volume polyethylene glycol solution: A prospective, randomized study of colon cleansing before colonoscopy

Science.gov (United States)

Hookey, Lawrence C; Depew, William T; Vanner, Stephen J

2006-01-01

INTRODUCTION The effectiveness of polyethylene glycol solutions (PEG) for colon cleansing is often limited by the inability of patients to drink adequate portions of the 4 L solution. The aim of the present study was to determine whether a reduced volume of PEG combined with stimulant laxatives would be better tolerated and as or more effective than the standard dose. METHODS Patients undergoing outpatient colonoscopy were randomly assigned to receive either low-volume PEG plus sennosides (120 mg oral sennosides syrup followed by 2 L PEG) or the standard volume preparation (4 L PEG). The subjects rated the tolerability of the preparations and their symptoms. Colonoscopists were blind to the colonic cleansing preparation and graded the cleansing efficacy using a validated tool (the Ottawa scale). RESULTS The low-volume PEG plus sennosides preparation was significantly better tolerated than the standard large volume PEG (Psennosides preparation was better tolerated, it was not as effective as standard large-volume PEG. However, in view of the significant difference in tolerance, further research investigating possible improvements in the reduced-volume regimen seems warranted. PMID:16482236

Fort Stewart integrated resource assessment. Volume 3: Resource assessment

Energy Technology Data Exchange (ETDEWEB)

Sullivan, G.P.; Keller, J.M.; Stucky, D.J.; Wahlstrom, R.R.; Larson, L.L.

1993-10-01

The US Army Forces Command (FORSCOM) has tasked the US Department of Energy (DOE) Federal Energy Management Program (FEMP), supported by the Pacific Northwest Laboratory, to identify, evaluate, and assist in acquiring all cost-effective energy projects at Fort Stewart. This is part of a model program that PNL is designing to support energy-use decisions in the federal sector. This report provides the results of the fossil fuel and electric energy resource opportunity (ERO) assessments performed by PNL at the FORSCOM Fort Stewart facility located approximately 25 miles southwest of Savannah, Georgia. It is a companion report to Volume 1, Executive Summary, and Volume 2, Baseline Detail. The results of the analyses of EROs are presented in 11 common energy end-use categories (e.g., boilers and furnaces, service hot water, and building lighting). A narrative description of each ERO is provided, along with a table detailing information on the installed cost, energy and dollar savings; impacts on operations and maintenance (O&M); and, when applicable, a discussion of energy supply and demand, energy security, and environmental issues. A description of the evaluation methodologies and technical and cost assumptions is also provided for each ERO. Summary tables present the cost-effectiveness of energy end-use equipment before and after the implementation of each ERO. The tables also present the results of the life-cycle cost (LCC) analysis indicating the net present value (NPV) and savings to investment ratio (SIR) of each ERO.

Site Environmental Report for 2008, Volume 1

Energy Technology Data Exchange (ETDEWEB)

Lackner, Regina; Baskin, David; Fox, Robert; Jelinski, John; Pauer, Ron; Thorson, Patrick; Wahl, Linnea; Xu, Suying

2009-09-21

The Site Environmental Report for 2008 is an integrated report on the environmental programs at Lawrence Berkeley National Laboratory and satisfies the requirements of DOE order 231.1A, Environment, Safety, and Health Reporting. Volume II contains individual data results from surveillance and monitoring activities

Blood volume studies in chronic renal failure using radioactive 51Cr

International Nuclear Information System (INIS)

Chadda, V.S.; Mehta, S.R.; Mathur, D.

1975-01-01

Estimation of blood volume was carried out in 20 healthy subjects and in 25 patients suffering from chronic renal failure using radioactive 51 Cr. A detailed history, physical examination and investigations were also undertaken. On statistical evaluation, the red cell volume was diminished significantly in males and females but rise in blood volume was insignificant. Plasma volume was raised significantly in females but was insignificant in males. The reduction in red cell volume is due to reduced red cell mass because of chronic renal disease. Plasma volume may be elevated in order to compensate for decreased red cell volume. The variability in these two parameters results in variable blood volume. (author)

Tracer responses and control of vessels with variable flow and volume

International Nuclear Information System (INIS)

Niemi, A.J.

1990-01-01

Continuous flow vessels which are subject to variation of flow and volume are characterized by time-variable parameters. It is shown that their residence time distributions and weighting functions obtained by tracer testing are made invariant with regard to the integrated flow variables which are introduced. Under variable flow but constant volume, one such integrated variable is sufficient. Under variable volume, two different variables are suggested for the residence time distribution and weighting function, while the appropriate variable of the perfect mixer differs distinctly from that of vessels with a distinct velocity profile. It is shown through a number of example cases, that an agreement with their mathematical models is reached. The approach is extended to include also arbitrary, non-analytic response functions obtained by tracer measurements. Applications of the derived models and their incorporation in automatic control algorithms is discussed. (orig.) [de

Penalized differential pathway analysis of integrative oncogenomics studies

NARCIS (Netherlands)

van Wieringen, W.N.; van de Wiel, M.A.

2014-01-01

Through integration of genomic data from multiple sources, we may obtain a more accurate and complete picture of the molecular mechanisms underlying tumorigenesis. We discuss the integration of DNA copy number and mRNA gene expression data from an observational integrative genomics study involving

ARL Summer Student Research Symposium Volume I: Select Presentations

Science.gov (United States)

2017-06-01

papers to an audience of ARL scientists and engineers, including the ARL Director and an ARL Fellows panel. This volume of the Summer Student Symposium...program. As an integral part of their summer study, all students are required to write a paper on their work which summarizes their major activity and its...end product. The program is conducted on two separate competitive levels: undergraduate and graduate. The format of the paper in both levels is the

Semiautomatic regional segmentation to measure orbital fat volumes in thyroid-associated ophthalmopathy. A validation study.

Science.gov (United States)

Comerci, M; Elefante, A; Strianese, D; Senese, R; Bonavolontà, P; Alfano, B; Bonavolontà, B; Brunetti, A

2013-08-01

This study was designed to validate a novel semi-automated segmentation method to measure regional intra-orbital fat tissue volume in Graves' ophthalmopathy. Twenty-four orbits from 12 patients with Graves' ophthalmopathy, 24 orbits from 12 controls, ten orbits from five MRI study simulations and two orbits from a digital model were used. Following manual region of interest definition of the orbital volumes performed by two operators with different levels of expertise, an automated procedure calculated intra-orbital fat tissue volumes (global and regional, with automated definition of four quadrants). In patients with Graves' disease, clinical activity score and degree of exophthalmos were measured and correlated with intra-orbital fat volumes. Operator performance was evaluated and statistical analysis of the measurements was performed. Accurate intra-orbital fat volume measurements were obtained with coefficients of variation below 5%. The mean operator difference in total fat volume measurements was 0.56%. Patients had significantly higher intra-orbital fat volumes than controls (p<0.001 using Student's t test). Fat volumes and clinical score were significantly correlated (p<0.001). The semi-automated method described here can provide accurate, reproducible intra-orbital fat measurements with low inter-operator variation and good correlation with clinical data.

Industrial experience feedback of a geostatistical estimation of contaminated soil volumes - 59181

International Nuclear Information System (INIS)

Faucheux, Claire; Jeannee, Nicolas

2012-01-01

Geo-statistics meets a growing interest for the remediation forecast of potentially contaminated sites, by providing adapted methods to perform both chemical and radiological pollution mapping, to estimate contaminated volumes, potentially integrating auxiliary information, and to set up adaptive sampling strategies. As part of demonstration studies carried out for GeoSiPol (Geo-statistics for Polluted Sites), geo-statistics has been applied for the detailed diagnosis of a former oil depot in France. The ability within the geo-statistical framework to generate pessimistic / probable / optimistic scenarios for the contaminated volumes allows a quantification of the risks associated to the remediation process: e.g. the financial risk to excavate clean soils, the sanitary risk to leave contaminated soils in place. After a first mapping, an iterative approach leads to collect additional samples in areas previously identified as highly uncertain. Estimated volumes are then updated and compared to the volumes actually excavated. This benchmarking therefore provides a practical feedback on the performance of the geo-statistical methodology. (authors)

Recent advances in marching-on-in-time schemes for solving time domain volume integral equations

KAUST Repository

Sayed, Sadeed Bin; Ulku, Huseyin Arda; Bagci, Hakan

2015-01-01

Transient electromagnetic field interactions on inhomogeneous penetrable scatterers can be analyzed by solving time domain volume integral equations (TDVIEs). TDVIEs are constructed by setting the summation of the incident and scattered field intensities to the total field intensity on the volumetric support of the scatterer. The unknown can be the field intensity or flux/current density. Representing the total field intensity in terms of the unknown using the relevant constitutive relation and the scattered field intensity in terms of the spatiotemporal convolution of the unknown with the Green function yield the final form of the TDVIE. The unknown is expanded in terms of local spatial and temporal basis functions. Inserting this expansion into the TDVIE and testing the resulting equation at discrete times yield a system of equations that is solved by the marching on-in-time (MOT) scheme. At each time step, a smaller system of equations, termed MOT system is solved for the coefficients of the expansion. The right-hand side of this system consists of the tested incident field and discretized spatio-temporal convolution of the unknown samples computed at the previous time steps with the Green function.

Recent advances in marching-on-in-time schemes for solving time domain volume integral equations

KAUST Repository

Sayed, Sadeed Bin

2015-05-16

Transient electromagnetic field interactions on inhomogeneous penetrable scatterers can be analyzed by solving time domain volume integral equations (TDVIEs). TDVIEs are constructed by setting the summation of the incident and scattered field intensities to the total field intensity on the volumetric support of the scatterer. The unknown can be the field intensity or flux/current density. Representing the total field intensity in terms of the unknown using the relevant constitutive relation and the scattered field intensity in terms of the spatiotemporal convolution of the unknown with the Green function yield the final form of the TDVIE. The unknown is expanded in terms of local spatial and temporal basis functions. Inserting this expansion into the TDVIE and testing the resulting equation at discrete times yield a system of equations that is solved by the marching on-in-time (MOT) scheme. At each time step, a smaller system of equations, termed MOT system is solved for the coefficients of the expansion. The right-hand side of this system consists of the tested incident field and discretized spatio-temporal convolution of the unknown samples computed at the previous time steps with the Green function.

Integration of Three-Dimensional Rotational Angiography in Radiosurgical Treatment Planning of Cerebral Arteriovenous Malformations

International Nuclear Information System (INIS)

Conti, Alfredo; Pontoriero, Antonio; Farago, Giuseppe; Midili, Federica; Siragusa, Carmelo; Granata, Francesca; Pitrone, Antonio; De Renzis, Costantino; Longo, Marcello; Tomasello, Francesco

2011-01-01

Purpose: Accuracy in delineating the target volume is a major issue for successful stereotactic radiosurgery for arteriovenous malformations. The aim of the present study was to describe a method to integrate three-dimensional (3D) rotational angiography ( (3DRA)) into CyberKnife treatment planning and to investigate its potential advantages compared with computed tomography angiography (CTA) and magnetic resonance angiography. Methods and Materials: A total of 20 patients with a diagnosis of cerebral arteriovenous malformation were included in the present study. All patients underwent multislice computed tomography and 3D-volumetric CTA, (3DRA), and 3D magnetic resonance angiography. The contouring of the target and critical volumes was done separately using CTA and thereafter directly using (3DRA). The composite, conjoint, and disjoint volumes were measured. Results: The use of CTA or (3DRA) resulted in significant differences in the target and critical volumes. The target volume averaged 3.49 ± 3.01 mL measured using CTA and 3.26 ± 2.93 mL measured using (3DRA), for a difference of 8% (p < .05). The conjoint and disjoint volume analysis showed an 88% volume overlap. The qualitative evaluation showed that the excess volume obtained using CTA was mostly tissue surrounding the nidus and venous structures. The mean contoured venous volume was 0.67 mL measured using CTA and 0.88 mL (range, 0.1-2.7) measured using (3DRA) (p < .05). Conclusions: (3DRA) is a volumetric angiographic study that can be integrated into computer-based treatment planning. Although whether (3DRA) provides superior accuracy has not yet been proved, its high spatial resolution is attractive and offers a superior 3D view. This allows a better 3D understanding of the target volume and distribution of the radiation doses within the volume. Additional technical efforts to improve the temporal resolution and the development of software tools aimed at improving the performance of 3D contouring are

Thermal-hydraulic study of integrated steam generator in PWR

International Nuclear Information System (INIS)

Osakabe, Masahiro

1989-01-01

One of the safety aspects of innovative reactor concepts is the integration of steam generators (SGs) into the reactor vessel in the case of the pressurized water reactor (PWR). All of the reactor system components including the pressurizer are within the reactor vessel in the SG integrated PWR. The simple heat transfer code was developed for the parametric study of the integrated SG. The code was compared to the once-through 19-tube SG experiment and the good agreement between the experimental results and the code predictions was obtained. The assessed code was used for the parametric study of the integrated once-through 16 m-straight-tube SG installed in the annular downcomer. The proposed integrated SG as a first attempt has approximately the same tube size and pitch as the present PWR and the SG primary and secondary sides in the present PWR is inverted in the integrated PWR. Based on the study, the reactor vessel size of the SG integrated PWR was calculated. (author)

Increased gray matter volume of left pars opercularis in male orchestral musicians correlate positively with years of musical performance.

Science.gov (United States)

Abdul-Kareem, Ihssan A; Stancak, Andrej; Parkes, Laura M; Sluming, Vanessa

2011-01-01

To compare manual volumetry of gray matter (GM) / white matter (WM) of Broca's area subparts: pars opercularis (POP) and pars triangularis (PTR) in both hemispheres between musicians and nonmusician, as it has been shown that these regions are crucial for musical abilities. A previous voxel-based morphometric (VBM) study conducted in our laboratory reported increased GM density in Broca's area of left hemisphere in male orchestral musicians. Functional segregation of POP/PTR justified separate volumetric analysis of these parts. We used the same cohort for the VBM study. Manual morphometry (stereology) was used to compare volumes between 26/26 right-handed orchestral musicians/nonmusicians. As expected, musicians showed significantly increased GM volume in the Broca's area, specifically in the left POP. No significant results were detected in right POP, left/right PTR GM volumes, and WM volumes for all regions. Results were positively correlated with years of musical performance (r = 0.7, P = 0.0001). This result corroborates the VBM study and is in line with the hypothesis of critical involvement of POP in hearing-action integration being an integral component of frontoparietotemporal mirror neuron network. We hypothesize that increased size of musicians' left POP represent use-dependent structural adaptation in response to intensive audiomotor skill acquisition. Copyright © 2010 Wiley-Liss, Inc.

Volumetric Spectroscopic Imaging of Glioblastoma Multiforme Radiation Treatment Volumes

Energy Technology Data Exchange (ETDEWEB)

Parra, N. Andres [Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida (United States); Maudsley, Andrew A. [Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida (United States); Gupta, Rakesh K. [Department of Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, Haryana (India); Ishkanian, Fazilat; Huang, Kris [Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida (United States); Walker, Gail R. [Biostatistics and Bioinformatics Core Resource, Sylvester Cancer Center, University of Miami Miller School of Medicine, Miami, Florida (United States); Padgett, Kyle [Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida (United States); Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida (United States); Roy, Bhaswati [Department of Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, Haryana (India); Panoff, Joseph; Markoe, Arnold [Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida (United States); Stoyanova, Radka, E-mail: RStoyanova@med.miami.edu [Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida (United States)

2014-10-01

Purpose: Magnetic resonance (MR) imaging and computed tomography (CT) are used almost exclusively in radiation therapy planning of glioblastoma multiforme (GBM), despite their well-recognized limitations. MR spectroscopic imaging (MRSI) can identify biochemical patterns associated with normal brain and tumor, predominantly by observation of choline (Cho) and N-acetylaspartate (NAA) distributions. In this study, volumetric 3-dimensional MRSI was used to map these compounds over a wide region of the brain and to evaluate metabolite-defined treatment targets (metabolic tumor volumes [MTV]). Methods and Materials: Volumetric MRSI with effective voxel size of ∼1.0 mL and standard clinical MR images were obtained from 19 GBM patients. Gross tumor volumes and edema were manually outlined, and clinical target volumes (CTVs) receiving 46 and 60 Gy were defined (CTV{sub 46} and CTV{sub 60}, respectively). MTV{sub Cho} and MTV{sub NAA} were constructed based on volumes with high Cho and low NAA relative to values estimated from normal-appearing tissue. Results: The MRSI coverage of the brain was between 70% and 76%. The MTV{sub NAA} were almost entirely contained within the edema, and the correlation between the 2 volumes was significant (r=0.68, P=.001). In contrast, a considerable fraction of MTV{sub Cho} was outside of the edema (median, 33%) and for some patients it was also outside of the CTV{sub 46} and CTV{sub 60}. These untreated volumes were greater than 10% for 7 patients (37%) in the study, and on average more than one-third (34.3%) of the MTV{sub Cho} for these patients were outside of CTV{sub 60}. Conclusions: This study demonstrates the potential usefulness of whole-brain MRSI for radiation therapy planning of GBM and revealed that areas of metabolically active tumor are not covered by standard RT volumes. The described integration of MTV into the RT system will pave the way to future clinical trials investigating outcomes in patients treated based on

SOLID WASTE INTEGRATED FORECAST TECHNICAL (SWIFT) REPORT FY2005 THRU FY2035 VERSION 2005.0 VOLUME 1

Energy Technology Data Exchange (ETDEWEB)

BARCOT, R.A.

2005-04-13

The SWIFT Report provides up-to-date life cycle information about the radioactive solid waste expected to be managed by Hanford's Waste Management (WM) Project from onsite and offsite generators. This report is an annual update to the SWIFT 2004.1 report that was published in August 2004. The SWIFT Report is published in two volumes. SWIFT Volume II provides detailed analyses of the data, graphical representation, comparison to previous years, and waste generator specific information. The data contained in this report are the official data for solid waste forecasting. In this revision, the volume numbers have been switched to reflect the timing of their release. This particular volume provides the following data reports: (1) Summary volume data by DOE Office, company, and location; (2) Annual volume data by waste generator; (3) Annual waste specification record and physical waste form volume; (4) Radionuclide activities and dose-equivalent curies; and (5) Annual container type data by volume and count.

SOLID WASTE INTEGRATED FORECAST TECHNICAL (SWIFT) REPORT FY2005 THRU FY2035 VERSION 2005.0 VOLUME 1

International Nuclear Information System (INIS)

BARCOT, R.A.

2005-01-01

The SWIFT Report provides up-to-date life cycle information about the radioactive solid waste expected to be managed by Hanford's Waste Management (WM) Project from onsite and offsite generators. This report is an annual update to the SWIFT 2004.1 report that was published in August 2004. The SWIFT Report is published in two volumes. SWIFT Volume II provides detailed analyses of the data, graphical representation, comparison to previous years, and waste generator specific information. The data contained in this report are the official data for solid waste forecasting. In this revision, the volume numbers have been switched to reflect the timing of their release. This particular volume provides the following data reports: (1) Summary volume data by DOE Office, company, and location; (2) Annual volume data by waste generator; (3) Annual waste specification record and physical waste form volume; (4) Radionuclide activities and dose-equivalent curies; and (5) Annual container type data by volume and count

Three dimensional system integration

CERN Document Server

Papanikolaou, Antonis; Radojcic, Riko

2010-01-01

Three-dimensional (3D) integrated circuit (IC) stacking is the next big step in electronic system integration. It enables packing more functionality, as well as integration of heterogeneous materials, devices, and signals, in the same space (volume). This results in consumer electronics (e.g., mobile, handheld devices) which can run more powerful applications, such as full-length movies and 3D games, with longer battery life. This technology is so promising that it is expected to be a mainstream technology a few years from now, less than 10-15 years from its original conception. To achieve thi

Gauge and integrable theories in loop spaces

International Nuclear Information System (INIS)

Ferreira, L.A.; Luchini, G.

2012-01-01

We propose an integral formulation of the equations of motion of a large class of field theories which leads in a quite natural and direct way to the construction of conservation laws. The approach is based on generalized non-abelian Stokes theorems for p-form connections, and its appropriate mathematical language is that of loop spaces. The equations of motion are written as the equality of a hyper-volume ordered integral to a hyper-surface ordered integral on the border of that hyper-volume. The approach applies to integrable field theories in (1+1) dimensions, Chern-Simons theories in (2+1) dimensions, and non-abelian gauge theories in (2+1) and (3+1) dimensions. The results presented in this paper are relevant for the understanding of global properties of those theories. As a special byproduct we solve a long standing problem in (3+1)-dimensional Yang-Mills theory, namely the construction of conserved charges, valid for any solution, which are invariant under arbitrary gauge transformations.

Flat-plate solar array project. Volume 8: Project analysis and integration

Science.gov (United States)

Mcguire, P.; Henry, P.

1986-01-01

Project Analysis and Integration (PA&I) performed planning and integration activities to support management of the various Flat-Plate Solar Array (FSA) Project R&D activities. Technical and economic goals were established by PA&I for each R&D task within the project to coordinate the thrust toward the National Photovoltaic Program goals. A sophisticated computer modeling capability was developed to assess technical progress toward meeting the economic goals. These models included a manufacturing facility simulation, a photovoltaic power station simulation and a decision aid model incorporating uncertainty. This family of analysis tools was used to track the progress of the technology and to explore the effects of alternative technical paths. Numerous studies conducted by PA&I signaled the achievement of milestones or were the foundation of major FSA project and national program decisions. The most important PA&I activities during the project history are summarized. The PA&I planning function is discussed and how it relates to project direction and important analytical models developed by PA&I for its analytical and assessment activities are reviewed.

Path-integral Monte Carlo study of phonons in the bcc phase of Helium-3

OpenAIRE

Sorkin, V.; Polturak, E.; Adler, Joan

2006-01-01

Using Path Integral Monte Carlo and the Maximum Entropy method, we calculate the dynamic structure factor of solid He-3 in the bcc phase at a finite temperature of T = 1.6 K and a molar volume of 21.5 cm^3. From the single phonon dynamic structure factor, we obtain both the longitudinal and transverse phonon branches along the main crystalline directions, [001], [011] and [111]. Our results are compared with other theoretical predictions and available experimental data.

Ocean Thermal Energy Conversion (OTEC) platform configuration and integration. Volume II. Conceptual design. Final report

Energy Technology Data Exchange (ETDEWEB)

None

1978-06-01

The purpose of this project is to evaluate six candidate hullforms as candidates for the OTEC commercial plant. This volume is a summary of the conceptual design including facility requirements, cost, schedule, and site sensitivity. Two OTEC commercial plant configurations are considered in this study: the ship and the semi-submersible. Engineering drawings are presented. (WHR)

OTEC platform configuration and integration study. Volume I. Systems engineering and integration. Final report

Energy Technology Data Exchange (ETDEWEB)

None

1978-04-01

The economic success of an Ocean Thermal Energy Conversion (OTEC) system is highly dependent on a platform which provides adequate support for the power system, accommodates reliably the cold water pipe, and is most cost effective. The results of a study conducted for the Department of Energy to assess six generic types of platforms to determine the most satisfactory platform for severl potential sites are presented. The six platform configurations are ship, circular barge, semi-submersible, Tuned Sphere, submersible, and spar. These represent directional and symmetric types of platforms which operate on the surface, at the interface, and submerged. The five sites for this study were primarily New Orleans, Keahole Point (Hawaii), Brazil, and secondarily Key West and Puerto Rico. Electrical transmission of energy by submarine cable is the planned form of energy transmission for all sites except Brazil, where chemical conversion is to be the method of transmission. This study is devoted to the platform (or ocean systems) of the OTEC plant which is chiefly comprised of the hull and structure, the seawater system, the position control system, and miscellaneous support/assembly systems. The principal elements in the work breakdown structure for the commercial plants are presented. The assessment of the six platform configurations was conducted utilizing a baseline plan (100-MW(e) (Net)) and site (New Orleans) with variations from the baseline to cover the range of interested platforms and sites.

Site Environmental Report for 1999 - Volume 1

Energy Technology Data Exchange (ETDEWEB)

Ruggieri, M

2000-08-12

Each year, Ernest Orlando Lawrence Berkeley National Laboratory prepares an integrated report on its environmental programs to satisfy the requirements of United States Department of Energy Order 231.1. The Site Environmental Report for 1999 is intended to summarize Berkeley Lab's compliance with environmental standards and requirements, characterize environmental management efforts through surveillance and monitoring activities, and highlight significant programs and efforts for calendar year 1999. The report is separated into two volumes. Volume I contains a general overview of the Laboratory, the status of environmental programs, and summary results from surveillance and monitoring activities. Each chapter in Volume I begins with an outline of the sections that follow, including any tables or figures found in the chapter. Readers should use section numbers (e.g., {section}1.5) as navigational tools to find topics of interest in either the printed or the electronic version of the report. Volume II contains the individual data results from monitoring programs.

Integration of rainfall/runoff and geomorphological analyses flood hazard in small catchments: case studies from the southern Apennines (Italy)

Science.gov (United States)

Palumbo, Manuela; Ascione, Alessandra; Santangelo, Nicoletta; Santo, Antonio

2017-04-01

We present the first results of an analysis of flood hazard in ungauged mountain catchments that are associated with intensely urbanized alluvial fans. Assessment of hydrological hazard has been based on the integration of rainfall/runoff modelling of drainage basins with geomorphological analysis and mapping. Some small and steep, ungauged mountain catchments located in various areas of the southern Apennines, in southern Italy, have been chosen as test sites. In the last centuries, the selected basins have been subject to heavy and intense precipitation events, which have caused flash floods with serious damages in the correlated alluvial fan areas. Available spatial information (regional technical maps, DEMs, land use maps, geological/lithological maps, orthophotos) and an automated GIS-based procedure (ArcGis tools and ArcHydro tools) have been used to extract morphological, hydrological and hydraulic parameters. Such parameters have been used to run the HEC (Hydrologic Engineering Center of the US Army Corps of Engineers) software (GeoHMS, GeoRAS, HMS and RAS) based on rainfall-runoff models, which have allowed the hydrological and hydraulic simulations. As the floods occurred in the studied catchments have been debris flows dominated, the solid load simulation has been also performed. In order to validate the simulations, we have compared results of the modelling with the effects produced by past floods. Such effects have been quantified through estimations of both the sediment volumes within each catchment that have the potential to be mobilised (pre-event) during a sediment transfer event, and the volume of sediments delivered by the debris flows at basins' outlets (post-event). The post-event sediment volume has been quantified through post-event surveys and Lidar data. Evaluation of the pre-event sediment volumes in single catchments has been based on mapping of sediment storages that may constitute source zones of bed load transport and debris flows. For

Markers for blood-brain barrier integrity

DEFF Research Database (Denmark)

Saunders, Norman R; Dziegielewska, Katarzyna M; Møllgård, Kjeld

2015-01-01

In recent years there has been a resurgence of interest in brain barriers and various roles their intrinsic mechanisms may play in neurological disorders. Such studies require suitable models and markers to demonstrate integrity and functional changes at the interfaces between blood, brain......, and cerebrospinal fluid. Studies of brain barrier mechanisms and measurements of plasma volume using dyes have a long-standing history, dating back to the late nineteenth-century. Their use in blood-brain barrier studies continues in spite of their known serious limitations in in vivo applications. These were well...... known when first introduced, but seem to have been forgotten since. Understanding these limitations is important because Evans blue is still the most commonly used marker of brain barrier integrity and those using it seem oblivious to problems arising from its in vivo application. The introduction...

PRT Impact Study Pre-PRT Phase : Volume 1. Travel Analysis.

Science.gov (United States)

1976-03-01

Part of a three-volume work, this report describes the analysis performed on travel data collected for the Pre-PRT Impact Study. The data analyzed consist of travel behavior, travel patterns, model utilization and travel costs of various modes of tra...

Correlation of ultrasound estimated placental volume and umbilical cord blood volume in term pregnancy.

Science.gov (United States)

Pannopnut, Papinwit; Kitporntheranunt, Maethaphan; Paritakul, Panwara; Kongsomboon, Kittipong

2015-01-01

To investigate the correlation between ultrasound measured placental volume and collected umbilical cord blood (UCB) volume in term pregnancy. An observational cross-sectional study of term singleton pregnant women in the labor ward at Maha Chakri Sirindhorn Medical Center was conducted. Placental thickness, height, and width were measured using two-dimensional (2D) ultrasound and calculated for placental volume using the volumetric mathematic model. After the delivery of the baby, UCB was collected and measured for its volume immediately. Then, birth weight, placental weight, and the actual placental volume were analyzed. The Pearson's correlation was used to determine the correlation between each two variables. A total of 35 pregnant women were eligible for the study. The mean and standard deviation of estimated placental volume and actual placental volume were 534±180 mL and 575±118 mL, respectively. The median UCB volume was 140 mL (range 98-220 mL). The UCB volume did not have a statistically significant correlation with the estimated placental volume (correlation coefficient 0.15; p=0.37). However, the UCB volume was significantly correlated with the actual placental volume (correlation coefficient 0.62; pcorrelation coefficient 0.38; p=0.02). The estimated placental volume by 2D ultrasound was not significantly correlated with the UCB volume. Further studies to establish the correlation between the UCB volume and the estimated placental volume using other types of placental imaging may be needed.

Volume-preserving normal forms of Hopf-zero singularity

International Nuclear Information System (INIS)

Gazor, Majid; Mokhtari, Fahimeh

2013-01-01

A practical method is described for computing the unique generator of the algebra of first integrals associated with a large class of Hopf-zero singularity. The set of all volume-preserving classical normal forms of this singularity is introduced via a Lie algebra description. This is a maximal vector space of classical normal forms with first integral; this is whence our approach works. Systems with a nonzero condition on their quadratic parts are considered. The algebra of all first integrals for any such system has a unique (modulo scalar multiplication) generator. The infinite level volume-preserving parametric normal forms of any nondegenerate perturbation within the Lie algebra of any such system is computed, where it can have rich dynamics. The associated unique generator of the algebra of first integrals are derived. The symmetry group of the infinite level normal forms are also discussed. Some necessary formulas are derived and applied to appropriately modified Rössler and generalized Kuramoto–Sivashinsky equations to demonstrate the applicability of our theoretical results. An approach (introduced by Iooss and Lombardi) is applied to find an optimal truncation for the first level normal forms of these examples with exponentially small remainders. The numerically suggested radius of convergence (for the first integral) associated with a hypernormalization step is discussed for the truncated first level normal forms of the examples. This is achieved by an efficient implementation of the results using Maple. (paper)

Volume-preserving normal forms of Hopf-zero singularity

Science.gov (United States)

Gazor, Majid; Mokhtari, Fahimeh

2013-10-01

A practical method is described for computing the unique generator of the algebra of first integrals associated with a large class of Hopf-zero singularity. The set of all volume-preserving classical normal forms of this singularity is introduced via a Lie algebra description. This is a maximal vector space of classical normal forms with first integral; this is whence our approach works. Systems with a nonzero condition on their quadratic parts are considered. The algebra of all first integrals for any such system has a unique (modulo scalar multiplication) generator. The infinite level volume-preserving parametric normal forms of any nondegenerate perturbation within the Lie algebra of any such system is computed, where it can have rich dynamics. The associated unique generator of the algebra of first integrals are derived. The symmetry group of the infinite level normal forms are also discussed. Some necessary formulas are derived and applied to appropriately modified Rössler and generalized Kuramoto-Sivashinsky equations to demonstrate the applicability of our theoretical results. An approach (introduced by Iooss and Lombardi) is applied to find an optimal truncation for the first level normal forms of these examples with exponentially small remainders. The numerically suggested radius of convergence (for the first integral) associated with a hypernormalization step is discussed for the truncated first level normal forms of the examples. This is achieved by an efficient implementation of the results using Maple.

Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study

Directory of Open Access Journals (Sweden)

Brooks Samantha J

2011-11-01

Full Text Available Abstract Background Previous Magnetic Resonance Imaging (MRI studies of people with anorexia nervosa (AN have shown differences in brain structure. This study aimed to provide preliminary extensions of this data by examining how different levels of appetitive restraint impact on brain volume. Methods Voxel based morphometry (VBM, corrected for total intracranial volume, age, BMI, years of education in 14 women with AN (8 RAN and 6 BPAN and 21 women (HC was performed. Correlations between brain volume and dietary restraint were done using Statistical Package for the Social Sciences (SPSS. Results Increased right dorsolateral prefrontal cortex (DLPFC and reduced right anterior insular cortex, bilateral parahippocampal gyrus, left fusiform gyrus, left cerebellum and right posterior cingulate volumes in AN compared to HC. RAN compared to BPAN had reduced left orbitofrontal cortex, right anterior insular cortex, bilateral parahippocampal gyrus and left cerebellum. Age negatively correlated with right DLPFC volume in HC but not in AN; dietary restraint and BMI predicted 57% of variance in right DLPFC volume in AN. Conclusions In AN, brain volume differences were found in appetitive, somatosensory and top-down control brain regions. Differences in regional GMV may be linked to levels of appetitive restraint, but whether they are state or trait is unclear. Nevertheless, these discrete brain volume differences provide candidate brain regions for further structural and functional study in people with eating disorders.

Advanced Neutron Source enrichment study. Volume 2: Appendices -- Final report, Revision 12/94

International Nuclear Information System (INIS)

Bari, R.A.; Ludewig, H.; Weeks, J.

1994-01-01

A study has been performed of the impact on performance of using low enriched uranium (20% 235 U) or medium enriched uranium (35% 235 U) as an alternative fuel for the Advanced Neutron Source, which is currently designed to use uranium enriched to 93% 235 U. Higher fuel densities and larger volume cores were evaluated at the lower enrichments in terms of impact on neutron flux, safety, safeguards, technical feasibility, and cost. The feasibility of fabricating uranium silicide fuel at increasing material density was specifically addressed by a panel of international experts on research reactor fuels. The most viable alternative designs for the reactor at lower enrichments were identified and discussed. Several sensitivity analyses were performed to gain an understanding of the performance of the reactor at parametric values of power, fuel density, core volume, and enrichment that were interpolations between the boundary values imposed on the study or extrapolations from known technology. Volume 2 of this report contains 26 appendices containing results, meeting minutes, and fuel panel presentations. There are 26 appendices in this volume

Demand Response and Energy Storage Integration Study

Energy Technology Data Exchange (ETDEWEB)

Ma, Ookie; Cheung, Kerry; Olsen, Daniel J.; Matson, Nance; Sohn, Michael D.; Rose, Cody M.; Dudley, Junqiao Han; Goli, Sasank; Kiliccote, Sila; Cappers, Peter; MacDonald, Jason; Denholm, Paul; Hummon, Marissa; Jorgenson, Jennie; Palchak, David; Starke, Michael; Alkadi, Nasr; Bhatnagar, Dhruv; Currier, Aileen; Hernandez, Jaci; Kirby, Brendan; O' Malley, Mark

2016-03-01

Demand response and energy storage resources present potentially important sources of bulk power system services that can aid in integrating variable renewable generation. While renewable integration studies have evaluated many of the challenges associated with deploying large amounts of variable wind and solar generation technologies, integration analyses have not yet fully incorporated demand response and energy storage resources. This report represents an initial effort in analyzing the potential integration value of demand response and energy storage, focusing on the western United States. It evaluates two major aspects of increased deployment of demand response and energy storage: (1) Their operational value in providing bulk power system services and (2) Market and regulatory issues, including potential barriers to deployment.

Study of the influence of volume fraction of ceramic inclusions in NiCr-TiC composite with columnar structure on its mechanical behavior

Science.gov (United States)

Eremina, Galina M.; Smolin, Alexey Yu.; Shilko, Evgeny V.

2017-12-01

Metal-ceramic materials are characterized by high mechanical and tribological properties. The surface treatment of the composite by an electron beam in inert gas plasma leads to a qualitative and quantitative change in its microstructure as well as to a change in mechanical properties of the components: a columnar structure forms in the modified layer. Different treatment regimes result in different concentrations of inclusions in the surface layer. In this paper, the effect of the volume concentration of inclusions on the integral mechanical properties of a dispersion-strengthened NiCr-TiC composite is studied on the basis of 3D numerical simulation. The results of computer simulation show that the change in concentration significantly affects the integral mechanical characteristics of the composite material as well as the nature of the nucleation and development of damages in it.

Some aspects of free volume studies in molecular substances using positron annihilation experiments

International Nuclear Information System (INIS)

Shantarovich, V.P.; Gustov, V.W.; Kevdina, I.B.; Suzuki, T.; Djourelov, N.; Shimazu, A.

2005-01-01

Positron annihilation lifetime spectroscopy is accepted now as a method for the studies of elementary free volumes (free volume holes) in solids, in polymers in particular. The aim of this paper is to discuss some problems, the difficulties on the way of this application and to illustrate them by several examples obtained by the authors. (author)

CASE STUDIES IN INTEGRATIVE PSYCHOTHERAPY PART 2 (EDITORIAL

Directory of Open Access Journals (Sweden)

Gregor Žvelc

2013-05-01

Full Text Available Announcement of the special issue of the International Journal of Integrative Psychotherapy, which is dedicated to the exploration and discussion of an integrative psychotherapy case study.

Forecasting on the total volumes of Malaysia's imports and exports by multiple linear regression

Science.gov (United States)

Beh, W. L.; Yong, M. K. Au

2017-04-01

This study is to give an insight on the doubt of the important of macroeconomic variables that affecting the total volumes of Malaysia's imports and exports by using multiple linear regression (MLR) analysis. The time frame for this study will be determined by using quarterly data of the total volumes of Malaysia's imports and exports covering the period between 2000-2015. The macroeconomic variables will be limited to eleven variables which are the exchange rate of US Dollar with Malaysia Ringgit (USD-MYR), exchange rate of China Yuan with Malaysia Ringgit (RMB-MYR), exchange rate of European Euro with Malaysia Ringgit (EUR-MYR), exchange rate of Singapore Dollar with Malaysia Ringgit (SGD-MYR), crude oil prices, gold prices, producer price index (PPI), interest rate, consumer price index (CPI), industrial production index (IPI) and gross domestic product (GDP). This study has applied the Johansen Co-integration test to investigate the relationship among the total volumes to Malaysia's imports and exports. The result shows that crude oil prices, RMB-MYR, EUR-MYR and IPI play important roles in the total volumes of Malaysia's imports. Meanwhile crude oil price, USD-MYR and GDP play important roles in the total volumes of Malaysia's exports.

Review of Department of Defense Education Activity (DODEA) Schools. Volume II: Quantitative Analysis of Educational Quality

National Research Council Canada - National Science Library

Anderson, Lowell

2000-01-01

This volume compiles, and presents in integrated form, IDA's quantitative analysis of educational quality provided by DoD's dependent schools, It covers the quantitative aspects of volume I in greater...

Dynamic Isotope Power System (DIPS) Applications Study. Volume II. Nuclear Integrated Multimission Spacecraft (NIMS) design definition. Final report

International Nuclear Information System (INIS)

1979-11-01

The design requirements for the Nuclear Integrated Multimission Spacecraft. (NIMS) are discussed in detail. The requirements are a function of mission specifications, payload, control system requirements, electric system specifications, and cost limitations

The nucleon-nucleon correlations and the integral characteristics of the potential distributions in nuclei

International Nuclear Information System (INIS)

Knyaz'kov, O.M.; Kukhtina, I.N.

1989-01-01

The integral characteristics of the potential distribution in nuclei, namely the volume integrals, moments and mean square radii are studied in the framework of the semimicroscopic approach to the interaction of low energy nucleons with nuclei on the base of the exchange nucleon-nucleon correlations and the density dependence of effective forces. The ratio of the normalized multipole moments of potential and matter distributions is investigated. The energy dependence of the integral characteristics is analyzed. 15 refs.; 2 tabs

Target Centroid Position Estimation of Phase-Path Volume Kalman Filtering

Directory of Open Access Journals (Sweden)

Fengjun Hu

2016-01-01

Full Text Available For the problem of easily losing track target when obstacles appear in intelligent robot target tracking, this paper proposes a target tracking algorithm integrating reduced dimension optimal Kalman filtering algorithm based on phase-path volume integral with Camshift algorithm. After analyzing the defects of Camshift algorithm, compare the performance with the SIFT algorithm and Mean Shift algorithm, and Kalman filtering algorithm is used for fusion optimization aiming at the defects. Then aiming at the increasing amount of calculation in integrated algorithm, reduce dimension with the phase-path volume integral instead of the Gaussian integral in Kalman algorithm and reduce the number of sampling points in the filtering process without influencing the operational precision of the original algorithm. Finally set the target centroid position from the Camshift algorithm iteration as the observation value of the improved Kalman filtering algorithm to fix predictive value; thus to make optimal estimation of target centroid position and keep the target tracking so that the robot can understand the environmental scene and react in time correctly according to the changes. The experiments show that the improved algorithm proposed in this paper shows good performance in target tracking with obstructions and reduces the computational complexity of the algorithm through the dimension reduction.

Volume Ray Casting with Peak Finding and Differential Sampling

KAUST Repository

Knoll, A.; Hijazi, Y.; Westerteiger, R.; Schott, M.; Hansen, C.; Hagen, H.

2009-01-01

classification. In this paper, we introduce a method for rendering such features by explicitly solving for isovalues within the volume rendering integral. In addition, we present a sampling strategy inspired by ray differentials that automatically matches

Tidal volume and mortality in mechanically ventilated children: a systematic review and meta-analysis of observational studies*.

Science.gov (United States)

de Jager, Pauline; Burgerhof, Johannes G M; van Heerde, Marc; Albers, Marcel J I J; Markhorst, Dick G; Kneyber, Martin C J

2014-12-01

To determine whether tidal volume is associated with mortality in critically ill, mechanically ventilated children. MEDLINE, EMBASE, and CINAHL databases from inception until July 2013 and bibliographies of included studies without language restrictions. Randomized clinical trials and observational studies reporting mortality in mechanically ventilated PICU patients. Two authors independently selected studies and extracted data on study methodology, quality, and patient outcomes. Meta-analyses were performed using the Mantel-Haenszel random-effects model. Heterogeneity was quantified using I. Study quality was assessed using the Newcastle-Ottawa Score for cohort studies. Out of 142 citations, seven studies met the inclusion criteria, and additional two articles were identified from references of the found articles. One was excluded. These eight studies included 1,756 patients. Mortality rates ranged from 13% to 42%. There was no association between tidal volume and mortality when tidal volume was dichotomized at 7, 8, 10, or 12 mL/kg. Comparing patients ventilated with tidal volume less than 7 mL/kg and greater than 10 mL/kg or greater than 12 mL/kg and tidal volume less than 8 mL/kg and greater than 10 mL/kg or greater than 12 mL/kg also showed no association between tidal volume and mortality. Limiting the analysis to patients with acute lung injury/acute respiratory distress syndrome did not change these results. Heterogeneity was observed in all pooled analyses. A relationship between tidal volume and mortality in mechanically ventilated children could not be identified, irrespective of the severity of disease. The significant heterogeneity observed in the pooled analyses necessitates future studies in well-defined patient populations to understand the effects of tidal volume on patient outcome.

Scaling for integral simulation of thermal-hydraulic phenomena in SBWR during LOCA

Energy Technology Data Exchange (ETDEWEB)

Ishii, M.; Revankar, S.T.; Dowlati, R [Purdue Univ., West Layfayette, IN (United States)] [and others

1995-09-01

A scaling study has been conducted for simulation of thermal-hydraulic phenomena in the Simplified Boiling Water Reactor (SBWR) during a loss of coolant accident. The scaling method consists of a three-level scaling approach. The integral system scaling (global scaling or top down approach) consists of two levels, the integral response function scaling which forms the first level, and the control volume and boundary flow scaling which forms the second level. The bottom up approach is carried out by local phenomena scaling which forms the third level scaling. Based on this scaling study the design of the model facility called Purdue University Multi-Dimensional Integral Test Assembly (PUMA) has been carried out. The PUMA facility has 1/4 height and 1/100 area ratio scaling, corresponding to the volume scaling of 1/400. The PUMA power scaling based on the integral scaling is 1/200. The present scaling method predicts that PUMA time scale will be one-half that of the SBWR. The system pressure for PUMA is full scale, therefore, a prototypic pressure is maintained. PUMA is designed to operate at and below 1.03 MPa (150 psi), which allows it to simulate the prototypic SBWR accident conditions below 1.03 MPa (150 psi). The facility includes models for all components of importance.

Building integrated care systems: a case study of Bidasoa Integrated Health Organisation

Directory of Open Access Journals (Sweden)

Nuria Toro Polanco

2015-06-01

Full Text Available Introduction: This paper analyses the implementation of integrated care policies in the Basque Country through the deployment of an Integrated Health Organisation in Bidasoa area during the period 2011–2014. Structural, functional and clinical integration policies have been employed with the aim to deliver integrated and person-centred care for patients, especially for those living with chronic conditions.Methods: This organisational case study used multiple data sources and methods in a pragmatic and reflexive manner to build a picture of the organisational development over a 4-year period. In order to measure the progress of integration three concepts have been measured: (i readiness for chronicity measured with Assessment of Readiness for Chronicity in Healthcare Organisations tool; (ii collaboration between clinicians from different care levels measured with the D'Amour Questionnaire, and (iii overall impact of integration through several indicators based on the Triple Aim Framework.Results: The measurement of organisational readiness for chronicity showed improvements in five of the six areas under evaluation. Similarly the collaboration between professionals of different care levels showed a steady improvement in each of the 10 items. Furthermore, the Triple Aim-based indicators showed a better experience of care in terms of patients’ perceptions of care coordination; a reduction in hospital utilisation, particularly for patients with complex chronic conditions; and cost-containment in terms of per capita expenditure.Conclusion: There is a significant amount of data that shows that Bidasoa Integrated Health Organisation has progressed in terms of delivering integrated care for chronic conditions with a positive impact on several Triple Aim outcomes.

Building integrated care systems: a case study of Bidasoa Integrated Health Organisation

Directory of Open Access Journals (Sweden)

Nuria Toro Polanco

2015-06-01

Full Text Available Introduction: This paper analyses the implementation of integrated care policies in the Basque Country through the deployment of an Integrated Health Organisation in Bidasoa area during the period 2011–2014. Structural, functional and clinical integration policies have been employed with the aim to deliver integrated and person-centred care for patients, especially for those living with chronic conditions. Methods: This organisational case study used multiple data sources and methods in a pragmatic and reflexive manner to build a picture of the organisational development over a 4-year period. In order to measure the progress of integration three concepts have been measured: (i readiness for chronicity measured with Assessment of Readiness for Chronicity in Healthcare Organisations tool; (ii collaboration between clinicians from different care levels measured with the D'Amour Questionnaire, and (iii overall impact of integration through several indicators based on the Triple Aim Framework. Results: The measurement of organisational readiness for chronicity showed improvements in five of the six areas under evaluation. Similarly the collaboration between professionals of different care levels showed a steady improvement in each of the 10 items. Furthermore, the Triple Aim-based indicators showed a better experience of care in terms of patients’ perceptions of care coordination; a reduction in hospital utilisation, particularly for patients with complex chronic conditions; and cost-containment in terms of per capita expenditure. Conclusion: There is a significant amount of data that shows that Bidasoa Integrated Health Organisation has progressed in terms of delivering integrated care for chronic conditions with a positive impact on several Triple Aim outcomes.

Integrated thermal treatment system study -- Phase 2 results. Revision 1

Energy Technology Data Exchange (ETDEWEB)

Feizollahi, F.; Quapp, W.J.

1996-02-01

This report presents the second phase of a study on thermal treatment technologies. The study consists of a systematic assessment of nineteen thermal treatment alternatives for the contact-handled mixed low-level waste (MLLW) currently stored in the US Department of Energy complex. The treatment alternatives consist of widely varying technologies for safely destroying the hazardous organic components, reducing the volume, and preparing for final disposal of the MLLW. The alternatives considered in Phase 2 were innovative thermal treatments with nine types of primary processing units. Other variations in the study examined the effect of combustion gas, air pollution control system design, and stabilization technology for the treatment residues. The Phase 1 study examined ten initial thermal treatment alternatives. The Phase 2 systems were evaluated in essentially the same manner as the Phase 1 systems. The alternatives evaluated were: rotary kiln, slagging kiln, plasma furnace, plasma gasification, molten salt oxidation, molten metal waste destruction, steam gasification, Joule-heated vitrification, thermal desorption and mediated electrochemical oxidation, and thermal desorption and supercritical water oxidation. The quantities, and physical and chemical compositions, of the input waste used in the Phase 2 systems differ from those in the Phase 1 systems, which were based on a preliminary waste input database developed at the onset of the Integrated Thermal Treatment System study. The inventory database used in the Phase 2 study incorporates the latest US Department of Energy information. All systems, both primary treatment systems and subsystem inputs, have now been evaluated using the same waste input (2,927 lb/hr). 28 refs., 88 figs., 41 tabs.

Integrated thermal treatment system study -- Phase 2 results. Revision 1

International Nuclear Information System (INIS)

Feizollahi, F.; Quapp, W.J.

1996-02-01

This report presents the second phase of a study on thermal treatment technologies. The study consists of a systematic assessment of nineteen thermal treatment alternatives for the contact-handled mixed low-level waste (MLLW) currently stored in the US Department of Energy complex. The treatment alternatives consist of widely varying technologies for safely destroying the hazardous organic components, reducing the volume, and preparing for final disposal of the MLLW. The alternatives considered in Phase 2 were innovative thermal treatments with nine types of primary processing units. Other variations in the study examined the effect of combustion gas, air pollution control system design, and stabilization technology for the treatment residues. The Phase 1 study examined ten initial thermal treatment alternatives. The Phase 2 systems were evaluated in essentially the same manner as the Phase 1 systems. The alternatives evaluated were: rotary kiln, slagging kiln, plasma furnace, plasma gasification, molten salt oxidation, molten metal waste destruction, steam gasification, Joule-heated vitrification, thermal desorption and mediated electrochemical oxidation, and thermal desorption and supercritical water oxidation. The quantities, and physical and chemical compositions, of the input waste used in the Phase 2 systems differ from those in the Phase 1 systems, which were based on a preliminary waste input database developed at the onset of the Integrated Thermal Treatment System study. The inventory database used in the Phase 2 study incorporates the latest US Department of Energy information. All systems, both primary treatment systems and subsystem inputs, have now been evaluated using the same waste input (2,927 lb/hr). 28 refs., 88 figs., 41 tabs

To what extent do long-duration high-volume dam releases influence river-aquifer interactions? A case study in New South Wales, Australia

Science.gov (United States)

Graham, P. W.; Andersen, M. S.; McCabe, M. F.; Ajami, H.; Baker, A.; Acworth, I.

2015-03-01

Long-duration high-volume dam releases are unique anthropogenic events with no naturally occurring equivalents. The impact from such dam releases on a downstream Quaternary alluvial aquifer in New South Wales, Australia, is assessed. It is observed that long-duration (>26 days), high-volume dam releases (>8,000 ML/day average) result in significant variations in river-aquifer interactions. These variations include a flux from the river to the aquifer up to 6.3 m3/day per metre of bank (at distances of up to 330 m from the river bank), increased extent and volume of recharge/bank storage, and a long-term (>100 days) reversal of river-aquifer fluxes. In contrast, during lower-volume events (bank. A groundwater-head prediction model was constructed and river-aquifer fluxes were calculated; however, predicted fluxes from this method showed poor correlation to fluxes calculated using actual groundwater heads. Long-duration high-volume dam releases have the potential to skew estimates of long-term aquifer resources and detrimentally alter the chemical and physical properties of phreatic aquifers flanking the river. The findings have ramifications for improved integrated management of dam systems and downstream aquifers.

Cell Volume Regulation and Signaling in 3T3-L1 Pre-adipocytes and Adipocytes

DEFF Research Database (Denmark)

Eduardsen, Kathrine; Larsen, Susanne; Novak, Ivana

2011-01-01

Caveolae have been implicated in sensing of cell volume perturbations, yet evidence is still limited and findings contradictory. Here, we investigated the possible role of caveolae in cell volume regulation and volume sensitive signaling in an adipocyte system with high (3T3-L1 adipocytes......); intermediate (3T3-L1 pre-adipocytes); and low (cholesterol-depleted 3T3-L1 pre-adipocytes) caveolae levels. Using large-angle light scattering, we show that compared to pre-adipocytes, differentiated adipocytes exhibit several-fold increased rates of volume restoration following osmotic cell swelling (RVD......) and osmotic cell shrinkage (RVI), accompanied by increased swelling-activated taurine efflux. However, caveolin-1 distribution was not detectably altered after osmotic swelling or shrinkage, and caveolae integrity, as studied by cholesterol depletion or expression of dominant negative Cav-1, was not required...

Volume Dynamics Propulsion System Modeling for Supersonics Vehicle Research

Science.gov (United States)

Kopasakis, George; Connolly, Joseph W.; Paxson, Daniel E.; Ma, Peter

2010-01-01

Under the NASA Fundamental Aeronautics Program the Supersonics Project is working to overcome the obstacles to supersonic commercial flight. The proposed vehicles are long slim body aircraft with pronounced aero-servo-elastic modes. These modes can potentially couple with propulsion system dynamics; leading to performance challenges such as aircraft ride quality and stability. Other disturbances upstream of the engine generated from atmospheric wind gusts, angle of attack, and yaw can have similar effects. In addition, for optimal propulsion system performance, normal inlet-engine operations are required to be closer to compressor stall and inlet unstart. To study these phenomena an integrated model is needed that includes both airframe structural dynamics as well as the propulsion system dynamics. This paper covers the propulsion system component volume dynamics modeling of a turbojet engine that will be used for an integrated vehicle Aero-Propulso-Servo-Elastic model and for propulsion efficiency studies.

Advanced transportation system studies technical area 3: Alternate propulsion subsystem concepts, volume 2

Science.gov (United States)

Levak, Daniel

1993-01-01

The Alternate Propulsion Subsystem Concepts contract had five tasks defined for the first year. The tasks were: F-1A Restart Study, J-2S Restart Study, Propulsion Database Development, Space Shuttle Main Engine (SSME) Upper Stage Use, and CER's for Liquid Propellant Rocket Engines. The detailed study results, with the data to support the conclusions from various analyses, are being reported as a series of five separate Final Task Reports. Consequently, this volume only reports the required programmatic information concerning Computer Aided Design Documentation, and New Technology Reports. A detailed Executive Summary, covering all the tasks, is also available as Volume 1.

Study of n-γ discrimination by digital charge comparison method for a large volume liquid scintillator

International Nuclear Information System (INIS)

Moszynski, M.; Costa, G.J.; Guillaume, G.; Heusch, B.; Huck, A.; Ring, C.; Bizard, G.; Durand, D.; Peter, J.; Tamain, B.; El Masri, Y.; Hanappe, F.

1992-01-01

The study of the n-γ discrimination for a large 41 volume BC501A liquid scintillator coupled to a 130 mm diameter XP4512B photomultiplier was carried out by digital charge comparison method. A very good n-γ discrimination down to 100 keV of recoil electron energy was achieved. The measured relative intensity of the charge integrated at the slow component of the scintillation pulse and the photoelectron yield of the tested counter allow the factor of merit of the n-γ discrimination spectra to be calculated and to be compared with those measured experimentally. This shows that the main limitation of the n-γ discrimination is associated with the statistical fluctuation of the photoelectron number at the slow component. A serious effect of the distortion in the cable used to send the photomultiplier pulse to the electronics for the n-γ discrimination was studied. This suggests that the length of RG58 cable should be limited to about 40 m to preserve a high quality n-γ discrimination. (orig.)

14th International Conference on Integral Methods in Science and Engineering

CERN Document Server

Riva, Matteo; Lamberti, Pier; Musolino, Paolo

2017-01-01

This contributed volume contains a collection of articles on the most recent advances in integral methods.  The first of two volumes, this work focuses on the construction of theoretical integral methods. Written by internationally recognized researchers, the chapters in this book are based on talks given at the Fourteenth International Conference on Integral Methods in Science and Engineering, held July 25-29, 2016, in Padova, Italy. A broad range of topics is addressed, such as: • Integral equations • Homogenization • Duality methods • Optimal design • Conformal techniques This collection will be of interest to researchers in applied mathematics, physics, and mechanical and electrical engineering, as well as graduate students in these disciplines, and to other professionals who use integration as an essential tool in their work.

Three-dimensional volume rendering of tibiofibular joint space and quantitative analysis of change in volume due to tibiofibular syndesmosis diastases

International Nuclear Information System (INIS)

Taser, F.; Shafiq, Q.; Ebraheim, N.A.

2006-01-01

The diagnosis of ankle syndesmosis injuries is made by various imaging techniques. The present study was undertaken to examine whether the three-dimensional reconstruction of axial CT images and calculation of the volume of tibiofibular joint space enhances the sensitivity of diastases diagnoses or not. Six adult cadaveric ankle specimens were used for spiral CT-scan assessment of tibiofibular syndesmosis. After the specimens were dissected, external fixation was performed and diastases of 1, 2, and 3 mm was simulated by a precalibrated device. Helical CT scans were obtained with 1.0-mm slice thickness. The data was transferred to the computer software AcquariusNET. Then the contours of the tibiofibular syndesmosis joint space were outlined on each axial CT slice and the collection of these slices were stacked using the computer software AutoCAD 2005, according to the spatial arrangement and geometrical coordinates between each slice, to produce a three-dimensional reconstruction of the joint space. The area of each slice and the volume of the entire tibiofibular joint space were calculated. The tibiofibular joint space at the 10th-mm slice level was also measured on axial CT scan images at normal, 1, 2 and 3-mm joint space diastases. The three-dimensional volume-rendering of the tibiofibular syndesmosis joint space from the spiral CT data demonstrated the shape of the joint space and has been found to be a sensitive method for calculating joint space volume. We found that, from normal to 1 mm, a 1-mm diastasis increases approximately 43% of the joint space volume, while from 1 to 3 mm, there is about a 20% increase for each 1-mm increase. Volume calculation using this method can be performed in cases of syndesmotic instability after ankle injuries and for preoperative and postoperative evaluation of the integrity of the tibiofibular syndesmosis. (orig.)

Introduction: Integration as a three-way process approach?

NARCIS (Netherlands)

Garcés-Mascareñas, B.; Penninx, R.; Garcés-Mascareñas, B.; Penninx, R.

2016-01-01

This chapter introduces the topic of this volume, which is the recent departure from viewing integration as a strictly two-way process (between migrants and the receiving society) to acknowledge the potential role that countries of origin might play in support of the integration process. It traces

Procedures for treating common cause failures in safety and reliability studies: Volume 2, Analytic background and techniques: Final report

International Nuclear Information System (INIS)

Mosleh, A.; Fleming, K.N.; Parry, G.W.; Paula, H.M.; Worledge, D.H.; Rasmuson, D.M.

1988-12-01

This report presents a framework for the inclusion of the impact of common cause failures in risk and reliability evaluations. Common cause failures are defined as that subset of dependent failures for which causes are not explicitly included in the logic model as basic events. The emphasis here is on providing procedures for a practical, systematic approach that can be used to perform and clearly document the analysis. The framework and the methods discussed for performing the different stages of the analysis integrate insights obtained from engineering assessments of the system and the historical evidence from multiple failure events into a systematic, reproducible, and defensible analysis. This document, Volume 2, contains a series of appendices that provide additional background and methodological detail on several important topics discussed in Volume 1

Quantum Coherent States and Path Integral Method to Stochastically Determine the Anisotropic Volume Expansion in Lithiated Silicon Nanowires

Directory of Open Access Journals (Sweden)

Donald C. Boone

2017-10-01

Full Text Available This computational research study will analyze the multi-physics of lithium ion insertion into a silicon nanowire in an attempt to explain the electrochemical kinetics at the nanoscale and quantum level. The electron coherent states and a quantum field version of photon density waves will be the joining theories that will explain the electron-photon interaction within the lithium-silicon lattice structure. These two quantum particles will be responsible for the photon absorption rate of silicon atoms that are hypothesized to be the leading cause of breaking diatomic silicon covalent bonds that ultimately leads to volume expansion. It will be demonstrated through the combination of Maxwell stress tensor, optical amplification and path integrals that a stochastic analyze using a variety of Poisson distributions that the anisotropic expansion rates in the <110>, <111> and <112> orthogonal directions confirms the findings ascertained in previous works made by other research groups. The computational findings presented in this work are similar to those which were discovered experimentally using transmission electron microscopy (TEM and simulation models that used density functional theory (DFT and molecular dynamics (MD. The refractive index and electric susceptibility parameters of lithiated silicon are interwoven in the first principle theoretical equations and appears frequently throughout this research presentation, which should serve to demonstrate the importance of these parameters in the understanding of this component in lithium ion batteries.

Impacts of Outer Continental Shelf (OCS) development on recreation and tourism. Volume 2. Final report and case studies

Energy Technology Data Exchange (ETDEWEB)

1987-04-01

The final report for the project is comprised of five volumes. The volume presents the study conclusions, summarizes the methodology used (more detail is found in Volume 3), discusses four case study applications of the model, and contains profiles of coastal communities in an Appendix.

An unstructured-mesh finite-volume MPDATA for compressible atmospheric dynamics

International Nuclear Information System (INIS)

Kühnlein, Christian; Smolarkiewicz, Piotr K.

2017-01-01

An advancement of the unstructured-mesh finite-volume MPDATA (Multidimensional Positive Definite Advection Transport Algorithm) is presented that formulates the error-compensative pseudo-velocity of the scheme to rely only on face-normal advective fluxes to the dual cells, in contrast to the full vector employed in previous implementations. This is essentially achieved by expressing the temporal truncation error underlying the pseudo-velocity in a form consistent with the flux-divergence of the governing conservation law. The development is especially important for integrating fluid dynamics equations on non-rectilinear meshes whenever face-normal advective mass fluxes are employed for transport compatible with mass continuity—the latter being essential for flux-form schemes. In particular, the proposed formulation enables large-time-step semi-implicit finite-volume integration of the compressible Euler equations using MPDATA on arbitrary hybrid computational meshes. Furthermore, it facilitates multiple error-compensative iterations of the finite-volume MPDATA and improved overall accuracy. The advancement combines straightforwardly with earlier developments, such as the nonoscillatory option, the infinite-gauge variant, and moving curvilinear meshes. A comprehensive description of the scheme is provided for a hybrid horizontally-unstructured vertically-structured computational mesh for efficient global atmospheric flow modelling. The proposed finite-volume MPDATA is verified using selected 3D global atmospheric benchmark simulations, representative of hydrostatic and non-hydrostatic flow regimes. Besides the added capabilities, the scheme retains fully the efficacy of established finite-volume MPDATA formulations.

An unstructured-mesh finite-volume MPDATA for compressible atmospheric dynamics

Energy Technology Data Exchange (ETDEWEB)

Kühnlein, Christian, E-mail: christian.kuehnlein@ecmwf.int; Smolarkiewicz, Piotr K., E-mail: piotr.smolarkiewicz@ecmwf.int

2017-04-01

An advancement of the unstructured-mesh finite-volume MPDATA (Multidimensional Positive Definite Advection Transport Algorithm) is presented that formulates the error-compensative pseudo-velocity of the scheme to rely only on face-normal advective fluxes to the dual cells, in contrast to the full vector employed in previous implementations. This is essentially achieved by expressing the temporal truncation error underlying the pseudo-velocity in a form consistent with the flux-divergence of the governing conservation law. The development is especially important for integrating fluid dynamics equations on non-rectilinear meshes whenever face-normal advective mass fluxes are employed for transport compatible with mass continuity—the latter being essential for flux-form schemes. In particular, the proposed formulation enables large-time-step semi-implicit finite-volume integration of the compressible Euler equations using MPDATA on arbitrary hybrid computational meshes. Furthermore, it facilitates multiple error-compensative iterations of the finite-volume MPDATA and improved overall accuracy. The advancement combines straightforwardly with earlier developments, such as the nonoscillatory option, the infinite-gauge variant, and moving curvilinear meshes. A comprehensive description of the scheme is provided for a hybrid horizontally-unstructured vertically-structured computational mesh for efficient global atmospheric flow modelling. The proposed finite-volume MPDATA is verified using selected 3D global atmospheric benchmark simulations, representative of hydrostatic and non-hydrostatic flow regimes. Besides the added capabilities, the scheme retains fully the efficacy of established finite-volume MPDATA formulations.

Positron annihilation and 129Xe NMR studies of free volume in polymers

International Nuclear Information System (INIS)

Nagasaka, Bunsow; Eguchi, Taro; Nakayama, Hirokazu; Nakamura, Nobuo; Ito, Yasuo

2000-01-01

The existence and the average size of free volume in bisphenol-A polycarbonate (PC), low-density polyethylene (LDPE), poly (2,6-dimethyl-phenylene oxide)(PPO), and polytetrafluoroethylene (PTFE) were studied by positron annihilation and 129 Xe NMR measurements. The 129 Xe NMR chemical shifts for xenon adsorbed in the polymers indicated that the average pore size of the free volume increased in the following order: PC, LDPE, PPO, and PTFE. This order of the pore size of the free volume agrees well with that estimated from the longest lifetime (τ 3 ) of ortho-positronium formed in the polymers. The unique correlation that δ -1 ∝ r is established between the 129 Xe NMR chemical shift (δ) and the pore size (r), which is deduced from the positron annihilation measurements.

Efficient visibility encoding for dynamic illumination in direct volume rendering.

Science.gov (United States)

Kronander, Joel; Jönsson, Daniel; Löw, Joakim; Ljung, Patric; Ynnerman, Anders; Unger, Jonas

2012-03-01

We present an algorithm that enables real-time dynamic shading in direct volume rendering using general lighting, including directional lights, point lights, and environment maps. Real-time performance is achieved by encoding local and global volumetric visibility using spherical harmonic (SH) basis functions stored in an efficient multiresolution grid over the extent of the volume. Our method enables high-frequency shadows in the spatial domain, but is limited to a low-frequency approximation of visibility and illumination in the angular domain. In a first pass, level of detail (LOD) selection in the grid is based on the current transfer function setting. This enables rapid online computation and SH projection of the local spherical distribution of visibility information. Using a piecewise integration of the SH coefficients over the local regions, the global visibility within the volume is then computed. By representing the light sources using their SH projections, the integral over lighting, visibility, and isotropic phase functions can be efficiently computed during rendering. The utility of our method is demonstrated in several examples showing the generality and interactive performance of the approach.

Integrated Unmanned Air-Ground Robotics System, Volume 4

Science.gov (United States)

2001-08-20

3) IPT Integrated Product Team IRP Intermediate Power Rating JAUGS TBD JCDL TBD Joint Vision 2020 TBD Km Kilometer lbs. pounds MAE Mechanical and...compatible with emerging JCDL and/or JAUGS . 2.3.2.2. Payload must be “plug and play.” 2.3.3. Communications 2.3.3.1. System communications shall be robust...Power JCDL JAUGS Joint Architecture for Unmanned Ground Systems JP-8 Jet Propulsion Fuel 8 km Kilometer lbs. Pounds LOS Line Of Sight MAE Mechanical

Multi-GPU-based acceleration of the explicit time domain volume integral equation solver using MPI-OpenACC

KAUST Repository

Feki, Saber

2013-07-01

An explicit marching-on-in-time (MOT)-based time-domain volume integral equation (TDVIE) solver has recently been developed for characterizing transient electromagnetic wave interactions on arbitrarily shaped dielectric bodies (A. Al-Jarro et al., IEEE Trans. Antennas Propag., vol. 60, no. 11, 2012). The solver discretizes the spatio-temporal convolutions of the source fields with the background medium\\'s Green function using nodal discretization in space and linear interpolation in time. The Green tensor, which involves second order spatial and temporal derivatives, is computed using finite differences on the temporal and spatial grid. A predictor-corrector algorithm is used to maintain the stability of the MOT scheme. The simplicity of the discretization scheme permits the computation of the discretized spatio-temporal convolutions on the fly during time marching; no \\'interaction\\' matrices are pre-computed or stored resulting in a memory efficient scheme. As a result, most often the applicability of this solver to the characterization of wave interactions on electrically large structures is limited by the computation time but not the memory. © 2013 IEEE.

Nuclear legislation analytical study. Regulatory and institutional framework for nuclear activities in OECD member countries. Volume II

International Nuclear Information System (INIS)

1984-01-01

This study is part of a series of analytical studies of the major aspects of nuclear legislation in OECD Member countries and is published in two volumes. This volume II of the study is a revision and an expansion of a 1969 study concerning the organisation and general regime governing nuclear activities. The national studies were prepared, to the extent possible, following a standard plan for all countries to facilitate information retrieval and comparison. This volume also contains tables of international conventions of relevance to the nuclear field. (NEA) [fr

Study of the impacts of regulations affecting the acceptance of integrated community energy systems. Final report

Energy Technology Data Exchange (ETDEWEB)

Feurer, Duane A.; Weaver, Clifford L.; Rielley, Kevin J.; Gallagher, Kevin C.; Harmon, Susan B.; Hejna, David T.; Kitch, Edmund W.

1981-01-01

A detailed description is presented of the laws and programs of the State of North Carolina governing the regulation of public energy utilities, the siting of energy generating and transmission facilities, the municipal franchising of public energy utilities, and the prescription of rates to be charged by utilities including attendant problems of cost allocations, rate base and operating expense determinations, and rate of return allowances. These laws and programs are analyzed to identify impediments which they may present to the implementation of Integrated Community Energy Systems (ICES). This report is one of fifty-one separate volumes which describe such regulatory programs at the Federal level and in each state as background to the report entitled Community Energy Systems and the Law of Public Utilities - Volume One: An Overview. This report also contains a summary of a strategy described in Volume One - An Overview for overcoming these impediments by working within the existing regulatory framework and by making changes in the regulatory programs to enhance the likelihood of ICES implementation.

Quantitative study on lung volume and lung perfusion using SPECT and CT in thoracal tumors

International Nuclear Information System (INIS)

Beyer-Enke, S.A.; Goerich, J.; Strauss, L.G.

1988-01-01

22 patients with space occupying lesions in the thoracal region were investigated by computer tomography and by perfusion scintigraphy using SPECT. In order to evaluate the CT images quantitatively, the lung volume was determined using approximation method and compared with the perfusion in the SPECT study. For this, anatomically equivalent transaxial SPECT slices had been coordinated to the CT slices. Between the determined lung volumes and the activity in the ocrresponding layers, a statistically significant correlation was found. It could be shown that the stronger perfusion, frequently observed at the right side of the healthy lung, may be explained by an higher volume of the right pulmonary lobe. Whereas in benign displacing processes the relation activity to volume was similar to the one of the healthy lung, a strongly reduced perfusion together with inconspicuous lung volumes became apparent with malignant tumors. In addition to the great morphological evidence of CT and SPECT studies, additional informations regarding the dignity of displacing processes may be derived from the quantitative evaluation of both methods. (orig.) [de

The observation of biology implemented by integrated religion values in integrated Islamic school (Decriptive Study in X Integrated Senior Hight School Tasikmalaya)

Science.gov (United States)

Nurjanah, E.; Adisendjaja, Y. H.; Kusumastuti, M. N.

2018-05-01

The learning Integrated Religious value is one of the efforts to increase the motivation of learning and building the student character. This study aims to describe the application of Biology learning integrated religion values in Integrated Islamic School. Research methods used in this research is descriptive. Participants in this study involved the headmaster, headmaster of curriculum, biology teachers, boarding school teachers, the lead of boarding schools, and students. The instruments used are interview, observation and the student questionnaire about learning biology. The results showed that learning in X school consists of two curriculums, there was the curriculum of national education and curriculum of boarding school. The curriculum of national education referred to 2013 curriculum and boarding school curriculum referred to the curriculum of Salafi boarding school (Kitab Kuning). However, in its learning process not delivered integrated. The main obstacle to implementing the learning integrated religious values are 1) the background of general teacher education did not know of any connection between biology subject and subject that are studied in boarding school; 2) schools did not form the teaching team; 3) unavailability of materials integrated religious values.

Relationship of carotid arterial functional and structural changes to left atrial volume in untreated hypertension.

Science.gov (United States)

Jaroch, Joanna; Rzyczkowska, Barbara; Bociąga, Zbigniew; Vriz, Olga; Driussi, Caterina; Loboz-Rudnicka, Maria; Dudek, Krzysztof; Łoboz-Grudzień, Krystyna

2016-04-01

The contribution of arterial functional and structural changes to left ventricular (LV) diastolic dysfunction has been the area of recent research. There are some studies on the relationship between arterial stiffness (a.s.) and left atrial (LA) remodelling as a marker of diastolic burden. Little is known about the association of arterial structural changes and LA remodelling in hypertension (H). The aim of this study was to examine the relationship between carotid a.s. and intima-media thickness (IMT) and LA volume in subjects with H. The study included 245 previously untreated hypertensives (166 women and 79 men, mean age 53.7 ± 11.8 years). Each patient was subjected to echocardiography with measurement of LA volume, evaluation of left ventricular hypertrophy (LVH) and LV systolic/diastolic function indices, integrated assessment of carotid IMT and echo-tracking of a.s. and wave reflection parameters. Univariate regression analysis revealed significant correlations between indexed LA volume and selected clinical characteristics, echocardiographic indices of LVH and LV diastolic/systolic function and a.s./wave reflection parameters. The following parameters were identified as independent determinants of indexed LA volume on multivariate regression analysis: diastolic blood pressure (beta = -0.229, P arterial stiffness but not intima-media thickness and LA volume in patients with untreated hypertension.

Integration of multiwavelength lasers with fast electro-optical modulators

NARCIS (Netherlands)

Besten, den J.H.

2004-01-01

Photonic Integrated Circuits (PICs) are of key importance in Wavelength-Division Multiplexing (WDM) networks because of their reduced volume and packaging costs compared to discrete components. The research described in this thesis was focussed on the integration of WDM-lasers and Radio-Frequency

Integrated process analyses studies on mixed low level and transuranic wastes. Summary report

International Nuclear Information System (INIS)

1997-12-01

Options for integrated thermal and nonthermal treatment systems for mixed low-level waste (MLLW) are compared such as total life cycle cost (TLCC), cost sensitivities, risk, energy requirements, final waste volume, and aqueous and gaseous effluents. The comparisons were derived by requiring all conceptual systems to treat the same composition of waste with the same operating efficiency. Thus, results can be used as a general guideline for the selection of treatment and disposal concepts. However, specific applications of individual systems will require further analysis. The potential for cost saving options and the research and development opportunities are summarized

Integrated process analyses studies on mixed low level and transuranic wastes. Summary report

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-12-01

Options for integrated thermal and nonthermal treatment systems for mixed low-level waste (MLLW) are compared such as total life cycle cost (TLCC), cost sensitivities, risk, energy requirements, final waste volume, and aqueous and gaseous effluents. The comparisons were derived by requiring all conceptual systems to treat the same composition of waste with the same operating efficiency. Thus, results can be used as a general guideline for the selection of treatment and disposal concepts. However, specific applications of individual systems will require further analysis. The potential for cost saving options and the research and development opportunities are summarized.

A parallel coordinates style interface for exploratory volume visualization.

Science.gov (United States)

Tory, Melanie; Potts, Simeon; Möller, Torsten

2005-01-01

We present a user interface, based on parallel coordinates, that facilitates exploration of volume data. By explicitly representing the visualization parameter space, the interface provides an overview of rendering options and enables users to easily explore different parameters. Rendered images are stored in an integrated history bar that facilitates backtracking to previous visualization options. Initial usability testing showed clear agreement between users and experts of various backgrounds (usability, graphic design, volume visualization, and medical physics) that the proposed user interface is a valuable data exploration tool.

Special integrals of Gradshteyn and Ryzhik the proofs

CERN Document Server

Moll, Victor H

2014-01-01

A Guide to the Evaluation of IntegralsSpecial Integrals of Gradshetyn and Ryzhik: The Proofs provides self-contained proofs of a variety of entries in the frequently used table of integrals by I.S. Gradshteyn and I.M. Ryzhik. The book gives the most elementary arguments possible and uses Mathematica® to verify the formulas. Readers discover the beauty, patterns, and unexpected connections behind the formulas.Volume I collects 15 papers from Revista Scientia covering logarithmic integrals, the gamma function, trigonometric integrals, the beta function, the digamma function, the incomplete beta

Estimating traffic volume on Wyoming low volume roads using linear and logistic regression methods

Directory of Open Access Journals (Sweden)

Dick Apronti

2016-12-01

Full Text Available Traffic volume is an important parameter in most transportation planning applications. Low volume roads make up about 69% of road miles in the United States. Estimating traffic on the low volume roads is a cost-effective alternative to taking traffic counts. This is because traditional traffic counts are expensive and impractical for low priority roads. The purpose of this paper is to present the development of two alternative means of cost-effectively estimating traffic volumes for low volume roads in Wyoming and to make recommendations for their implementation. The study methodology involves reviewing existing studies, identifying data sources, and carrying out the model development. The utility of the models developed were then verified by comparing actual traffic volumes to those predicted by the model. The study resulted in two regression models that are inexpensive and easy to implement. The first regression model was a linear regression model that utilized pavement type, access to highways, predominant land use types, and population to estimate traffic volume. In verifying the model, an R2 value of 0.64 and a root mean square error of 73.4% were obtained. The second model was a logistic regression model that identified the level of traffic on roads using five thresholds or levels. The logistic regression model was verified by estimating traffic volume thresholds and determining the percentage of roads that were accurately classified as belonging to the given thresholds. For the five thresholds, the percentage of roads classified correctly ranged from 79% to 88%. In conclusion, the verification of the models indicated both model types to be useful for accurate and cost-effective estimation of traffic volumes for low volume Wyoming roads. The models developed were recommended for use in traffic volume estimations for low volume roads in pavement management and environmental impact assessment studies.

A governor's guide to emergency management. Volume two : homeland security

Science.gov (United States)

2002-09-19

Homeland security is a complex challenge that demands significant investment; collaboration among local, state, and federal governments; and integration with the private sector. The purpose of A Governor's Guide to Emergency Management Volume Two: Ho...

Review of the integrated thermal and nonthermal treatment system studies

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-08-01

This report contains a review and evaluation of three systems analysis studies performed by LITCO on integrated thermal treatment systems and integrated nonthermal treatment systems for the remediation of mixed low-level waste stored throughout the US Department of Energy weapons complex. The review was performed by an independent team of nine researchers from the Energy and Environmental Research Center, Science Applications International Corporation, the Waste Policy Institute, and Virginia Tech. The three studies reviewed were as follows: Integrated Thermal Treatment System Study, Phase 1--issued July 1994; Integrated Thermal Treatment System Study, Phase 2--issued February 1996; and Integrated Nonthermal Treatment System Study--drafted March 1996. The purpose of this review was to (1) determine whether the assumptions of the studies were adequate to produce an unbiased review of both thermal and nonthermal systems, (2) to identify the critical areas of the studies that would benefit from further investigation, and (3) to develop a standard template that could be used in future studies to assure a sound application of systems engineering.

Review of the integrated thermal and nonthermal treatment system studies

Energy Technology Data Exchange (ETDEWEB)

Durrani, H.A.; Schmidt, L.J.; Erickson, T.A.; Sondreal, E.A.; Erjavec, J.; Steadman, E.N.; Fabrycky, W.J.; Wilson, J.S.; Musich, M.A.

1996-07-01

This report analyzes three systems engineering (SE) studies performed on integrated thermal treatment systems (ITTSs) and integrated nonthermal treatment systems (INTSs) for the remediation of mixed low-level waste (MLLW) stored throughout the US Department of Energy (DOE) weapons complex. The review was performed by an independent team of nine researchers from the Energy and Environmental Research Center (EERC), Science Applications International Corporation (SAIC), the Waste Policy Institute (WPI), and Virginia Tech (VT). The three studies reviewed were as follows: Integrated Thermal Treatment System Study, Phase 1--issued July 1994; Integrated Thermal Treatment System Study, Phase 2--issued February 1996; and Integrated Nonthermal Treatment System Study--drafted March 1996. The purpose of this review was to (1) determine whether the assumptions taken in the studies might bias the resulting economic evaluations of both thermal and nonthermal systems, (2) identify the critical areas of the studies that would benefit from further investigation, and (3) develop a standard template that could be used in future studies to produce sound SE applications.

Review of the integrated thermal and nonthermal treatment system studies

International Nuclear Information System (INIS)

1996-08-01

This report contains a review and evaluation of three systems analysis studies performed by LITCO on integrated thermal treatment systems and integrated nonthermal treatment systems for the remediation of mixed low-level waste stored throughout the US Department of Energy weapons complex. The review was performed by an independent team of nine researchers from the Energy and Environmental Research Center, Science Applications International Corporation, the Waste Policy Institute, and Virginia Tech. The three studies reviewed were as follows: Integrated Thermal Treatment System Study, Phase 1--issued July 1994; Integrated Thermal Treatment System Study, Phase 2--issued February 1996; and Integrated Nonthermal Treatment System Study--drafted March 1996. The purpose of this review was to (1) determine whether the assumptions of the studies were adequate to produce an unbiased review of both thermal and nonthermal systems, (2) to identify the critical areas of the studies that would benefit from further investigation, and (3) to develop a standard template that could be used in future studies to assure a sound application of systems engineering

SU-F-T-40: Can CBCT Images Be Used for Volume Studies of Prostate Seed Implants for Boost Treatment?

Energy Technology Data Exchange (ETDEWEB)

Xu, H; Lee, S; Diwanji, T; Amin, P; Krudys, K; Guerrero, M [University of Maryland School of Medicine, Baltimore, MD (United States)

2016-06-15

Purpose: In our clinic, the planning CT is used for definitive and boost low-dose-rate (LDR) brachytherapy treatments to determine the ultrasound volume in the operating room (OR) at the time of the implant. While the CT overestimation of OR volume is known, a larger estimation discrepancy has been observed for boost treatments. A possible reason is the prostate size reduction during EBRT for boost patients. Since cone-beam CT (CBCT) is often used as routine imaging guidance of EBRT, this prostate volume change may be captured. This study investigates if CBCT taken during EBRT includes the volume change information and therefore beats CT in estimating the prostate OR volumes. Methods: 9 prostate patients treated with EBRT (45Gy in 1.8Gy per fractions to the whole pelvis) and I-125 seed implants (108Gy) were involved in this study. During EBRT, CBCT image guidance was performed on a weekly basis. For each patient, the prostate volumes on the first and the last available CBCT images were manually contoured by a physician. These volumes were then compared to each other and with the contoured volumes from the planning CT and from the ultrasound images in the OR. Results: The first and the last CBCT images did not show significant prostate volume change. Their average +/− standard deviation of prostate volumes were 24.4cc+/−14.6cc and 29.9cc+/−16.1cc, respectively (T-test p=0.68). The ratio of the OR volume to the last CBCT (0.71+/−0.21) was not significantly different from the ratio of OR volumes to the planning CT (0.61+/−0.13) (p=0.25). Conclusion: In this study, CBCT does not show significant prostate volume changes during EBRT. CBCT and CT volumes are quite consistent and no improvement of volume estimation using CBCT is observed. The advantage of CBCT as a replacement of CT for volume study of boost LDR brachytherapy is limited.

Free volume of cyanate resins studied by positron annihilation

International Nuclear Information System (INIS)

Suzuki, T.; Oki, Y.; Numajiri, M.; Miura, T.; Kondo, K.; Oshima, N.; Hayashi, T.; Nakamura, H.; Ito, Y.

1996-01-01

The polymerization process of bisphenol-A dicyanate (BADCy) has been studied using a positron-annihilation lifetime technique (PAL). The polymerization was conducted at 150 deg C, and the process was followed by PAL. Seven kinds of samples with different curing times were also formed at 150 deg C, and the relation between the period of the curing time and the degree of polymerization was studied. It has been shown that the ο-Ps lifetime increases in samples with a higher polymerization than 85%, which is consistent with measurements of the specific volume of BADCy. (author)

Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study

Directory of Open Access Journals (Sweden)

Rijken Marcus J

2012-01-01

Full Text Available Abstract Background The presence of malaria parasites and histopathological changes in the placenta are associated with a reduction in birth weight, principally due to intrauterine growth restriction. The aim of this study was to examine the feasibility of studying early pregnancy placental volumes using three-dimensional (3D ultrasound in a malaria endemic area, as a small volume in the second trimester may be an indicator of intra-uterine growth restriction and placental insufficiency. Methods Placenta volumes were acquired using a portable ultrasound machine and a 3D ultrasound transducer and estimated using the Virtual Organ Computer-aided AnaLysis (VOCAL image analysis software package. Intra-observer reliability and limits of agreement of the placenta volume measurements were calculated. Polynomial regression models for the mean and standard deviation as a function of gestational age for the placental volumes of uninfected women were created and tested. Based on these equations each measurement was converted into a z -score. The z-scores of the placental volumes of malaria infected and uninfected women were then compared. Results Eighty-four women (uninfected = 65; infected = 19 with a posterior placenta delivered congenitally normal, live born, single babies. The mean placental volumes in the uninfected women were modeled to fit 5th, 10th, 50th, 90th and 95th centiles for 14-24 weeks' gestation. Most placenta volumes in the infected women were below the 50th centile for gestational age; most of those with Plasmodium falciparum were below the 10th centile. The 95% intra-observer limits of agreement for first and second measurements were ± 37.0 mL and ± 25.4 mL at 30 degrees and 15 degrees rotation respectively. Conclusion The new technique of 3D ultrasound volumetry of the placenta may be useful to improve our understanding of the pathophysiological constraints on foetal growth caused by malaria infection in early pregnancy.

The Value of Children: A Cross-National Study, Volume Three. Hawaii.

Science.gov (United States)

Arnold, Fred; Fawcett, James T.

The document, one in a series of seven reports from the Value of Children Project, discusses results of the survey in Hawaii. Specifically, the study investigated the social, psychological, and economic costs and benefits associated with having children. The volume is presented in seven chapters. Chapter I describes the background of the study and…

Outer Continental Shelf Environmental Assessment Program. Final reports of principal investigators. Volume 74

International Nuclear Information System (INIS)

1991-10-01

The volume contains: synthesis of seismicity studies for western Alaska; bottom and near-bottom sediment dynamics in Norton Sound; integration of circulation data in the Beaufort Sea; numerical modeling of storm surges in the Beaufort and Chukchi Seas; numerical modeling of storm surges in Norton Sound; Yukon delta oceanography and meteorology; and superstructure icing and wave hindcast statistics in the Navarin and St. George Basin areas

68Ga-PSMA-PET/CT imaging of localized primary prostate cancer patients for intensity modulated radiation therapy treatment planning with integrated boost.

Science.gov (United States)

Thomas, Lena; Kantz, Steffi; Hung, Arthur; Monaco, Debra; Gaertner, Florian C; Essler, Markus; Strunk, Holger; Laub, Wolfram; Bundschuh, Ralph A

2018-07-01

The purpose of our study was to show the feasibility and potential benefits of using 68 Ga-PSMA-PET/CT imaging for radiation therapy treatment planning of patients with primary prostate cancer using either integrated boost on the PET-positive volume or localized treatment of the PET-positive volume. The potential gain of such an approach, the improvement of tumor control, and reduction of the dose to organs-at-risk at the same time was analyzed using the QUANTEC biological model. Twenty-one prostate cancer patients (70 years average) without previous local therapy received 68 Ga-PSMA-PET/CT imaging. Organs-at-risk and standard prostate target volumes were manually defined on the obtained datasets. A PET active volume (PTV_PET) was segmented with a 40% of the maximum activity uptake in the lesion as threshold followed by manual adaption. Five different treatment plan variations were calculated for each patient. Analysis of derived treatment plans was done according to QUANTEC with in-house developed software. Tumor control probability (TCP) and normal tissue complication probability (NTCP) was calculated for all plan variations. Comparing the conventional plans to the plans with integrated boost and plans just treating the PET-positive tumor volume, we found that TCP increased to (95.2 ± 0.5%) for an integrated boost with 75.6 Gy, (98.1 ± 0.3%) for an integrated boost with 80 Gy, (94.7 ± 0.8%) for treatment of PET-positive volume with 75 Gy, and to (99.4 ± 0.1%) for treating PET-positive volume with 95 Gy (all p PET/CT image information allows for more individualized prostate treatment planning. TCP values of identified active tumor volumes were increased, while rectum and bladder NTCP values either remained the same or were even lower. However, further studies need to clarify the clinical benefit for the patients applying these techniques.

Life sciences payload definition and integration study. Volume 3: Preliminary equipment item specification catalog for the carry-on laboratories. [for Spacelab

Science.gov (United States)

1974-01-01

All general purpose equipment items contained in the final carry-on laboratory (COL) design concepts are described in terms of specific requirements identified for COL use, hardware status, and technical parameters such as weight, volume, power, range, and precision. Estimated costs for each item are given, along with projected development times.

A preliminary study on the containment building integrity following BIT removal for nuclear power plant

Energy Technology Data Exchange (ETDEWEB)

Jo, Jong Young; Song, Dong Soo; Byun, Choong Sub [Korea Electric Power Research Institute, Daejeon (Korea, Republic of)

2008-07-01

Boron Injection Tank(BIT) is a component of the Safety Injection System, which its sole function is to provide concentrated boric acid to the reactor coolant in order to mitigate the consequences of postulated main steamline break accidents. Although BIT plays an important role in mitigating the accident, high concentration of 20,000ppm causes valve leakage, clog of precipitation and continuous heat tracing have to be provided. For the removal of BIT, benchmarking analysis is performed between COPATTA code used in final safety analysis report and CONTEMPT code to be used this study. CONTEMPT is well compatible with COPATTA. The sensitivity study for integrity is performed for the three cases of full double ended rupture at 102% power with diesel generator failure, 3.4m{sup 3} and 2400ppm BIT, 3.4m{sup 3} and 0ppm BIT and no volume of BIT. The results show that the deactivation of BIT is plausible for success.

A preliminary study on the containment building integrity following BIT removal for nuclear power plant

International Nuclear Information System (INIS)

Jo, Jong Young; Song, Dong Soo; Byun, Choong Sub

2008-01-01

Boron Injection Tank(BIT) is a component of the Safety Injection System, which its sole function is to provide concentrated boric acid to the reactor coolant in order to mitigate the consequences of postulated main steamline break accidents. Although BIT plays an important role in mitigating the accident, high concentration of 20,000ppm causes valve leakage, clog of precipitation and continuous heat tracing have to be provided. For the removal of BIT, benchmarking analysis is performed between COPATTA code used in final safety analysis report and CONTEMPT code to be used this study. CONTEMPT is well compatible with COPATTA. The sensitivity study for integrity is performed for the three cases of full double ended rupture at 102% power with diesel generator failure, 3.4m 3 and 2400ppm BIT, 3.4m 3 and 0ppm BIT and no volume of BIT. The results show that the deactivation of BIT is plausible for success

Integrated propulsion for near-Earth space missions. Volume 2: Technical

Science.gov (United States)

Dailey, C. L.; Meissinger, H. F.; Lovberg, R. H.; Zafran, S.

1981-01-01

The calculation approach is described for parametric analysis of candidate electric propulsion systems employed in LEO to GEO missions. Occultation relations, atmospheric density effects, and natural radiation effects are presented. A solar cell cover glass tradeoff is performed to determine optimum glass thickness. Solar array and spacecraft pointing strategies are described for low altitude flight and for optimum array illumination during ascent. Mass ratio tradeoffs versus transfer time provide direction for thruster technology improvements. Integrated electric propulsion analysis is performed for orbit boosting, inclination change, attitude control, stationkeeping, repositioning, and disposal functions as well as power sharing with payload on orbit. Comparison with chemical auxiliary propulsion is made to quantify the advantages of integrated propulsion in terms of weight savings and concomittant launch cost savings.

Relapse patterns after radiochemotherapy of glioblastoma with FET PET-guided boost irradiation and simulation to optimize radiation target volume

International Nuclear Information System (INIS)

Piroth, Marc D.; Galldiks, Norbert; Pinkawa, Michael; Holy, Richard; Stoffels, Gabriele; Ermert, Johannes; Mottaghy, Felix M.; Shah, N. Jon; Langen, Karl-Josef; Eble, Michael J.

2016-01-01

O-(2-18 F-fluoroethyl)-L-tyrosine-(FET)-PET may be helpful to improve the definition of radiation target volumes in glioblastomas compared with MRI. We analyzed the relapse patterns in FET-PET after a FET- and MRI-based integrated-boost intensity-modulated radiotherapy (IMRT) of glioblastomas to perform an optimized target volume definition. A relapse pattern analysis was performed in 13 glioblastoma patients treated with radiochemotherapy within a prospective phase-II-study between 2008 and 2009. Radiotherapy was performed as an integrated-boost intensity-modulated radiotherapy (IB-IMRT). The prescribed dose was 72 Gy for the boost target volume, based on baseline FET-PET (FET-1) and 60 Gy for the MRI-based (MRI-1) standard target volume. The single doses were 2.4 and 2.0 Gy, respectively. Location and volume of recurrent tumors in FET-2 and MRI-2 were analyzed related to initial tumor, detected in baseline FET-1. Variable target volumes were created theoretically based on FET-1 to optimally cover recurrent tumor. The tumor volume overlap in FET and MRI was poor both at baseline (median 12 %; range 0–32) and at time of recurrence (13 %; 0–100). Recurrent tumor volume in FET-2 was localized to 39 % (12–91) in the initial tumor volume (FET-1). Over the time a shrinking (mean 12 (5–26) ml) and shifting (mean 6 (1–10 mm) of the resection cavity was seen. A simulated target volume based on active tumor in FET-1 with an additional safety margin of 7 mm around the FET-1 volume covered recurrent FET tumor volume (FET-2) significantly better than a corresponding target volume based on contrast enhancement in MRI-1 with a same safety margin of 7 mm (100 % (54–100) versus 85 % (0–100); p < 0.01). A simulated planning target volume (PTV), based on FET-1 and additional 7 mm margin plus 5 mm margin for setup-uncertainties was significantly smaller than the conventional, MR-based PTV applied in this study (median 160 (112–297) ml versus 231 (117–386) ml, p < 0

Integrating Educational Technologies into Teacher Education: A Case Study

Science.gov (United States)

Rawlins, Peter; Kehrwald, Benjamin

2014-01-01

This article is a case study of an integrated, experiential approach to improving pre-service teachers' understanding and use of educational technologies in one New Zealand teacher education programme. The study examines the context, design and implementation of a learning activity which integrated student-centred approaches, experiential…

System studies on Biofuel production via Integrated Biomass Gasification

Energy Technology Data Exchange (ETDEWEB)

Andersson, Jim; Lundgren, Joakim [Luleaa Univ. of Technology Bio4Energy, Luleaa (Sweden); Malek, Laura; Hulteberg, Christian [Lund Univ., Lund (Sweden); Pettersson, Karin [Chalmers Univ. of Technology, Goeteborg (Sweden); Wetterlund, Elisabeth [Linkoeping Univ. Linkoeping (Sweden)

2013-09-01

A large number of national and international techno-economic studies on industrially integrated gasifiers for production of biofuels have been published during the recent years. These studies comprise different types of gasifiers (fluidized bed, indirect and entrained flow) integrated in different industries for the production of various types of chemicals and transportation fuels (SNG, FT-products, methanol, DME etc.) The results are often used for techno-economic comparisons between different biorefinery concepts. One relatively common observation is that even if the applied technology and the produced biofuel are the same, the results of the techno-economic studies may differ significantly. The main objective of this project has been to perform a comprehensive review of publications regarding industrially integrated biomass gasifiers for motor fuel production. The purposes have been to identify and highlight the main reasons why similar studies differ considerably and to prepare a basis for fair techno-economic comparisons. Another objective has been to identify possible lack of industrial integration studies that may be of interest to carry out in a second phase of the project. Around 40 national and international reports and articles have been analysed and reviewed. The majority of the studies concern gasifiers installed in chemical pulp and paper mills where black liquor gasification is the dominating technology. District heating systems are also well represented. Only a few studies have been found with mechanical pulp and paper mills, steel industries and the oil refineries as case basis. Other industries have rarely, or not at all, been considered for industrial integration studies. Surprisingly, no studies regarding integration of biomass gasification neither in saw mills nor in wood pellet production industry have been found. In the published economic evaluations, it has been found that there is a large number of studies containing both integration and

Theoretical study for volume changes associated with the helix-coil transition of peptides.

Science.gov (United States)

Imai, T; Harano, Y; Kovalenko, A; Hirata, F

2001-12-01

We calculate the partial molar volumes and their changes associated with the coil(extended)-to-helix transition of two types of peptide, glycine-oligomer and glutamic acid-oligomer, in aqueous solutions by using the Kirkwood-Buff solution theory coupled with the three-dimensional reference interaction site model (3D-RISM) theory. The volume changes associated with the transition are small and positive. The volume is analyzed by decomposing it into five contributions following the procedure proposed by Chalikian and Breslauer: the ideal volume, the van der Waals volume, the void volume, the thermal volume, and the interaction volume. The ideal volumes and the van der Waals volumes do not change appreciably upon the transition. In the both cases of glycine-peptide and glutamic acid-peptide, the changes in the void volumes are positive, while those in the thermal volumes are negative, and tend to balance those in the void volumes. The change in the interaction volume of glycine-peptide does not significantly contribute, while that of glutamic acid-peptide makes a negative contribution. Copyright 2001 John Wiley & Sons, Inc. Biopolymers 59: 512-519, 2001

Brachytherapy dose-volume histogram computations using optimized stratified sampling methods

International Nuclear Information System (INIS)

Karouzakis, K.; Lahanas, M.; Milickovic, N.; Giannouli, S.; Baltas, D.; Zamboglou, N.

2002-01-01

A stratified sampling method for the efficient repeated computation of dose-volume histograms (DVHs) in brachytherapy is presented as used for anatomy based brachytherapy optimization methods. The aim of the method is to reduce the number of sampling points required for the calculation of DVHs for the body and the PTV. From the DVHs are derived the quantities such as Conformity Index COIN and COIN integrals. This is achieved by using partial uniform distributed sampling points with a density in each region obtained from a survey of the gradients or the variance of the dose distribution in these regions. The shape of the sampling regions is adapted to the patient anatomy and the shape and size of the implant. For the application of this method a single preprocessing step is necessary which requires only a few seconds. Ten clinical implants were used to study the appropriate number of sampling points, given a required accuracy for quantities such as cumulative DVHs, COIN indices and COIN integrals. We found that DVHs of very large tissue volumes surrounding the PTV, and also COIN distributions, can be obtained using a factor of 5-10 times smaller the number of sampling points in comparison with uniform distributed points

LLE Review Quarterly Report (January-March 2000). Volume 82

Energy Technology Data Exchange (ETDEWEB)

Radha, P. B. [Univ. of Rochester, NY (United States). Lab. for Laser Energetics

2000-03-01

This volume of the LLE Review, covering the period January-March 2000, includes a report on OMEGA cryogenic target designs for the soon-to-be-commissioned OMEGA Cryogenic Target Handling System. R. P. J. Town, J. A. Delettrez, R. Epstein, V. N. Goncharov, P. W. McKenty, P. B. Radha, and S. Skupsky use two-dimensional hydrodynamic simulations in conjunction with a stability analysis model to study the performance of OMEGA cryogenic capsules. They show that these targets are energy-scaled from the NIF ignition designs and have similar 1-D behavior and stability properties. This similarity will facilitate the extrapolation of cryogenic target studies on OMEGA to ignition targets on the NIF. Other articles in this volume are: Imprint Reduction using an Intensity Spike in Omega Cryogenic Targets; Measurement of Preheat Due to Fast Electrons in Laser Implosions; Holographic Transmission Gratings for Spectral Dispersion; Laser Beam Smoothing Caused by the Small-Spatial-Scale B-Integral; Three-Dimensional Modeling of Capsule Implosions in OMEGA Tetrahedral Hohlraums; and, Nanoindentation Hardness of Particles Used in Magnetoheological finishing (MRF).

Evaluation of volume vascularization index and flow index: A phantom study

NARCIS (Netherlands)

M.J.N.C. Schulten-Wijman; P.C. Struijk (Pieter); C.A. Brezinka (Christoph); N. de Jong (Nico); R.P.M. Steegers-Theunissen (Régine)

2008-01-01

textabstractObjectives Three-dimensional (3D) power Doppler ultrasonography provides indices to quantify moving blood within a volume of interest (e.g. ovary, endometrium, tumor or placenta). The purpose of this study was to determine the influence of ultrasound instrument settings on

Continuous modelling study of numerical volumes - Applications to the visualization of anatomical structures

International Nuclear Information System (INIS)

Goret, C.

1990-12-01

Several technics of imaging (IRM, image scanners, tomoscintigraphy, echography) give numerical informations presented by means of a stack of parallel cross-sectional images. Since many years, 3-D mathematical tools have been developed and allow the 3 D images synthesis of surfaces. In first part, we give the technics of numerical volume exploitation and their medical applications to diagnosis and therapy. The second part is about a continuous modelling of the volume with a tensor product of cubic splines. We study the characteristics of this representation and its clinical validation. Finally, we treat of the problem of surface visualization of objects contained in the volume. The results show the interest of this model and allow to propose specifications for 3-D workstation realization [fr

[Evaluation of tidal volume delivered by ventilators during volume-controlled ventilation].

Science.gov (United States)

Zhou, Juan; Yan, Yong; Cao, Desen

2014-12-01

To study the ways which ensure the delivery of enough tidal volume to patients under various conditions close to the demand of the physician. The volume control ventilation model was chosen, and the simulation lung type was active servo lung ASL 5000 or Michigan lung 1601. The air resistance, air compliance and lung type in simulation lungs were set. The tidal volume was obtained from flow analyzer PF 300. At the same tidal volume, the displaying values of tidal volume of E5, Servo i, Evital 4, and Evital XL ventilators with different lung types of patient, compliance of gas piping, leakage, gas types, etc. were evaluated. With the same setting tidal volume of a same ventilator, the tidal volume delivered to patients was different with different lung types of patient, compliance of gas piping, leakage, gas types, etc. Reducing compliance and increasing resistance of the patient lungs caused high peak airway pressure, the tidal volume was lost in gas piping, and the tidal volume be delivered to the patient lungs was decreased. If the ventilator did not compensate to leakage, the tidal volume delivered to the patient lungs was decreased. When the setting gas type of ventilator did not coincide with that applying to the patient, the tidal volume be delivered to the patient lungs might be different with the setting tidal volume of ventilator. To ensure the delivery of enough tidal volume to patients close to the demand of the physician, containable factors such as the compliance of gas piping, leakage, and gas types should be controlled.

Accuracy of renal volume assessment in children by three-dimensional sonography

International Nuclear Information System (INIS)

Fritz, G.A.; Riccabona, M.; Bohdal, G.; Quehenberger, F.

2003-01-01

Purpose: Prospective evaluation of the accuracy of three-dimensional ultrasound (3DUS) to assess the renal parenchymal volume. Materials and Methods: CT, MRI, 2DUS and 3DUS were used to measure the renal volume in 40 patients (range: neonate to 17 years; mean age: 8.95 years). The 3DUS was determined with a Voluson 730 (Kretztechnik, GE) or an external 3D-system (EchoTech, GE) using electromagnetic positioning sensors attached to conventional 2DUS-equipment. The 2DUS volume was calculated with the ellipsoid equation and the 3DUS volume computed with the system integrated software. For CT and MRI, planimetric analysis was used to determine the renal parenchymal volume, whereby the dilated collecting system of a hydronephrosis was subtracted to obtain the real renal parenchymal volume. The results of 2DUS and 3DUS were compared to the results of CT and MRI, and inter- and intraobserver variabilities were calculated. Results: In 74 of 77 kidneys, the 3DUS study was of diagnostic quality. The accuracy of the 3DUS volumes compared well to the CT and MRI volumes with a mean difference of -1.8 ± 4.6% versus a mean difference of -2.4 ± 15.4% for 2DUS. In normal kidneys, the accuracy was -2.6 ± 4.4% for 3DUS and -3.8 ± 14.7% for 2DUS. In hydronephrosis, the accuracy was +4.0 ± 5.9% and +9.6 ± 21.3%, respectively, indicating that 3DUS is more accurate than 2DUS, particularly in kidneys with a dilated collecting system. Inter- and intraobserver variabilities were ± 7.3% and ± 5.3%. Conclusion: For assessing the renal parenchymal volume in children, 3DUS is feasible and comparable to CT and MRI. (orig.) [de

Development of Integrally Molded Bipolar Plates for All-Vanadium Redox Flow Batteries

Directory of Open Access Journals (Sweden)

Chih-Hsun Chang

2016-05-01

Full Text Available All-vanadium redox flow batteries (VRBs are potential energy storage systems for renewable power sources because of their flexible design, deep discharge capacity, quick response time, and long cycle life. To minimize the energy loss due to the shunt current, in a traditional design, a flow field is machined on two electrically insulated frames with a graphite plate in between. A traditional bipolar plate (BP of a VRB consists of many components, and thus, the assembly process is time consuming. In this study, an integrally molded BP is designed and fabricated to minimize the manufacturing cost. First, the effects of the mold design and injection parameters on frame formability were analyzed by simulation. Second, a new graphite plate design for integral molding was proposed, and finally, two integrally molded BPs were fabricated and compared. Results show that gate position significantly affects air traps and the maximum volume shrinkage occurs at the corners of a BP. The volume shrinkage can be reduced using a large graphite plate embedded within the frame.

Cold reservoir integrated into a brine circuit of energy roofing, coupled to a heat pump

Energy Technology Data Exchange (ETDEWEB)

Schroeder, M.

1983-12-01

Model studies are presented in which the economic effects of a cold reservoir integrated in a heat pump system were established. Cold reservoirs have the following advantages: 1. The absolute annual savings increase with the storage volume. Storage volumes of 1 to 10 m/sup 3/ are economical, depending on the mode of operation. 2. If the storage volume is sufficiently large, the heat pump (operated in a bivalent, parallel system) can supply a considerable amount of the required even below the design temperature. 3. With a sufficiently large storage volume, the heat pump may be operated in more or less monovalent mode even if the heat pump has not been designed for a minimum ambient temperature.

Penalized differential pathway analysis of integrative oncogenomics studies.

Science.gov (United States)

van Wieringen, Wessel N; van de Wiel, Mark A

2014-04-01

Through integration of genomic data from multiple sources, we may obtain a more accurate and complete picture of the molecular mechanisms underlying tumorigenesis. We discuss the integration of DNA copy number and mRNA gene expression data from an observational integrative genomics study involving cancer patients. The two molecular levels involved are linked through the central dogma of molecular biology. DNA copy number aberrations abound in the cancer cell. Here we investigate how these aberrations affect gene expression levels within a pathway using observational integrative genomics data of cancer patients. In particular, we aim to identify differential edges between regulatory networks of two groups involving these molecular levels. Motivated by the rate equations, the regulatory mechanism between DNA copy number aberrations and gene expression levels within a pathway is modeled by a simultaneous-equations model, for the one- and two-group case. The latter facilitates the identification of differential interactions between the two groups. Model parameters are estimated by penalized least squares using the lasso (L1) penalty to obtain a sparse pathway topology. Simulations show that the inclusion of DNA copy number data benefits the discovery of gene-gene interactions. In addition, the simulations reveal that cis-effects tend to be over-estimated in a univariate (single gene) analysis. In the application to real data from integrative oncogenomic studies we show that inclusion of prior information on the regulatory network architecture benefits the reproducibility of all edges. Furthermore, analyses of the TP53 and TGFb signaling pathways between ER+ and ER- samples from an integrative genomics breast cancer study identify reproducible differential regulatory patterns that corroborate with existing literature.

Study on structural integrity in box structures

International Nuclear Information System (INIS)

Asano, Masayuki; Ueta, Masahiro; Kanaoka, Tadashi; Ikeuchi, Toshiaki; Kodama, Tetsuhiro.

1991-01-01

This study was carried out to give an experimental foundation to the structural integrity of a box structure. Crack growth tests were performed on the reduced scale models, simulating typical portions of the box structure, in air at room temperature. The results show that the amount of crack growth is too small to injure the structural integrity of the models for the postulated loading cycle, and make clear the effective structure against crack growth. (author)

Investigation of Adaptive-threshold Approaches for Determining Area-Time Integrals from Satellite Infrared Data to Estimate Convective Rain Volumes

Science.gov (United States)

Smith, Paul L.; VonderHaar, Thomas H.

1996-01-01

The principal goal of this project is to establish relationships that would allow application of area-time integral (ATI) calculations based upon satellite data to estimate rainfall volumes. The research is being carried out as a collaborative effort between the two participating organizations, with the satellite data analysis to determine values for the ATIs being done primarily by the STC-METSAT scientists and the associated radar data analysis to determine the 'ground-truth' rainfall estimates being done primarily at the South Dakota School of Mines and Technology (SDSM&T). Synthesis of the two separate kinds of data and investigation of the resulting rainfall-versus-ATI relationships is then carried out jointly. The research has been pursued using two different approaches, which for convenience can be designated as the 'fixed-threshold approach' and the 'adaptive-threshold approach'. In the former, an attempt is made to determine a single temperature threshold in the satellite infrared data that would yield ATI values for identifiable cloud clusters which are closely related to the corresponding rainfall amounts as determined by radar. Work on the second, or 'adaptive-threshold', approach for determining the satellite ATI values has explored two avenues: (1) attempt involved choosing IR thresholds to match the satellite ATI values with ones separately calculated from the radar data on a case basis; and (2) an attempt involved a striaghtforward screening analysis to determine the (fixed) offset that would lead to the strongest correlation and lowest standard error of estimate in the relationship between the satellite ATI values and the corresponding rainfall volumes.

Multicenter Study of Brain Volume Abnormalities in Children and Adolescent-Onset Psychosis

Science.gov (United States)

Reig, Santiago; Parellada, Mara; Castro-Fornieles, Josefina; Janssen, Joost; Moreno, Dolores; Baeza, Inmaculada; Bargalló, Nuria; González-Pinto, Ana; Graell, Montserrat; Ortuño, Felipe; Otero, Soraya; Arango, Celso; Desco, Manuel

2011-01-01

The goal of the study is to determine the extent of structural brain abnormalities in a multicenter sample of children and adolescents with a recent-onset first episode of psychosis (FEP), compared with a sample of healthy controls. Total brain and lobar volumes and those of gray matter (GM), white matter, and cerebrospinal fluid (CSF) were measured in 92 patients with a FEP and in 94 controls, matched for age, gender, and years of education. Male patients (n = 64) showed several significant differences when compared with controls (n = 61). GM volume in male patients was reduced in the whole brain and in frontal and parietal lobes compared with controls. Total CSF volume and frontal, temporal, and right parietal CSF volumes were also increased in male patients. Within patients, those with a further diagnosis of “schizophrenia” or “other psychosis” showed a pattern similar to the group of all patients relative to controls. However, bipolar patients showed fewer differences relative to controls. In female patients, only the schizophrenia group showed differences relative to controls, in frontal CSF. GM deficit in male patients with a first episode correlated with negative symptoms. Our study suggests that at least part of the GM deficit in children and adolescent-onset schizophrenia and in other psychosis occurs before onset of the first positive symptoms and that, contrary to what has been shown in children-onset schizophrenia, frontal GM deficits are probably present from the first appearance of positive symptoms in children and adolescents. PMID:20478821

Volume-based characterization of postocclusion surge.

Science.gov (United States)

Zacharias, Jaime; Zacharias, Sergio

2005-10-01

To propose an alternative method to characterize postocclusion surge using a collapsible artificial anterior chamber to replace the currently used rigid anterior chamber model. Fundación Oftamológica Los Andes, Santiago, Chile. The distal end of a phacoemulsification handpiece was placed inside a compliant artificial anterior chamber. Digital recordings of chamber pressure, chamber volume, inflow, and outflow were performed during occlusion break of the phacoemulsification tip. The occlusion break profile of 2 different consoles was compared. Occlusion break while using a rigid anterior chamber model produced a simultaneous increase of chamber inflow and outflow. In the rigid chamber model, pressure decreased sharply, reaching negative pressure values. Alternatively, with the collapsible chamber model, a delay was observed in the inflow that occurs to compensate the outflow surge. Also, the chamber pressure drop was smaller in magnitude, never undershooting below atmospheric pressure into negative values. Using 500 mm Hg as vacuum limit, the Infiniti System (Alcon) performed better that the Legacy (Alcon), showing an 18% reduction in peak volume variation. The collapsible anterior chamber model provides a more realistic representation of the postocclusion surge events that occur in the real eye during cataract surgery. Peak volume fluctuation (mL), half volume recovery time(s), and volume fluctuation integral value (mL x s) are proposed as realistic indicators to characterize the postocclusion surge performance. These indicators show that the Infiniti System has a better postocclusion surge behavior than the Legacy System.

True Volumes of Slope Failure Estimated From a Quaternary Mass-Transport Deposit in the Northern South China Sea

Science.gov (United States)

Sun, Qiliang; Alves, Tiago M.; Lu, Xiangyang; Chen, Chuanxu; Xie, Xinong

2018-03-01

Submarine slope failure can mobilize large amounts of seafloor sediment, as shown in varied offshore locations around the world. Submarine landslide volumes are usually estimated by mapping their tops and bases on seismic data. However, two essential components of the total volume of failed sediments are overlooked in most estimates: (a) the volume of subseismic turbidites generated during slope failure and (b) the volume of shear compaction occurring during the emplacement of failed sediment. In this study, the true volume of a large submarine landslide in the northern South China Sea is estimated using seismic, multibeam bathymetry and Ocean Drilling Program/Integrated Ocean Drilling Program well data. The submarine landslide was evacuated on the continental slope and deposited in an ocean basin connected to the slope through a narrow moat. This particular character of the sea floor provides an opportunity to estimate the amount of strata remobilized by slope instability. The imaged volume of the studied landslide is 1035 ± 64 km3, 406 ± 28 km3 on the slope and 629 ± 36 km3 in the ocean basin. The volume of subseismic turbidites is 86 km3 (median value), and the volume of shear compaction is 100 km3, which are 8.6% and 9.7% of the landslide volume imaged on seismic data, respectively. This study highlights that the original volume of the failed sediments is significantly larger than that estimated using seismic and bathymetric data. Volume loss related to the generation of landslide-related turbidites and shear compaction must be considered when estimating the total volume of failed strata in the submarine realm.

Ultrasound and Histologic Examination after Subcutaneous Injection of Two Volumizing Hyaluronic Acid Fillers: A Preliminary Study

Science.gov (United States)

Besse, Stéphanie; Sarazin, Didier; Quinodoz, Pierre; Elias, Badwi; Safa, Marva; Vandeputte, Joan

2017-01-01

Background: This study examined the influence of hyaluronic acid (HA) crosslinking technology on the ultrasound and histologic behavior of HA fillers designed for subcutaneous injection. Methods: One subject received subcutaneous injections of 0.25 ml Cohesive Polydensified Matrix (CPM) and Vycross volumizing HA in tissue scheduled for abdominoplasty by bolus and retrograde fanning techniques. Ultrasound analyses were performed on days 0 and 8 and histologic analyses on days 0 and 21 after injection. A series of simple rheologic tests was also performed. Results: Day 0 ultrasound images after bolus injection showed CPM and Vycross as hypoechogenic papules in the hypodermis. CPM appeared little changed after gentle massage, whereas Vycross appeared more hyperechogenic and diminished in size. Ultrasound images at day 8 were similar. On day 0, both gels appeared less hypoechogenic after retrograde fanning than after bolus injection. Vycross was interspersed with hyperechogenic areas (fibrous septa from the fat network structure) and unlike CPM became almost completely invisible after gentle massage. On day 8, CPM appeared as a hypoechogenic pool and Vycross as a long, thin rod. Day 0 histologic findings confirmed ultrasound results. Day 21 CPM histologic findings showed a discrete inflammatory reaction along the injection row after retrograde fanning. Vycross had a more pronounced inflammatory reaction, particularly after retrograde fanning, with macrophages and giant cells surrounding the implant. Rheologic tests showed CPM to have greater cohesivity and resistance to traction forces than Vycross. Conclusions: CPM HA volumizer appears to maintain greater tissue integrity than Vycross after subcutaneous injection with less inflammatory activity. PMID:28280664

Patrick Air Force Base integrated resource assessment. Volume 2, Baseline detail

Energy Technology Data Exchange (ETDEWEB)

Wahlstrom, R.R.; King, D.A.; Parker, S.A.; Sandusky, W.F.

1993-08-01

The US Air Force has tasked the Pacific Northwest Laboratory (PNL), in support of the US Department of Energy (DOE) Federal Energy Management Program (FEMP), to assess energy use at Patrick Air Force Base (AFB). The information obtained from this assessment will be used in identifying energy resource opportunities to reduce overall energy consumption on the base. The primary focus of this report is to assess the current baseline energy consumption at Patrick AFB. It is a comparison report to Volume 1, the Executive Summary, and Volume 3, the Resource Assessment. This assessment requires that information be obtained and characterized for buildings, utilities, energy sources, energy uses, and load profile information to be used to improve the characterization of energy use on the base. The characteristics of electricity, natural gas, and No. 2 fuel oil are analyzed for on-base facilities and housing. The assessment examines basic regional information used to determine energy-use intensity (EUI) values for Patrick AFB facilities by building, fuel type, and energy end use. It also provides a summary of electricity consumption from Florida Power and Light Company (FPL) metered data for 1985-1991. Load profile information obtained from FPL data is presented for the north and south substations for the four seasons of the year, including weekdays and weekends.

Solar data inputs for integration and transmission planning studies

Energy Technology Data Exchange (ETDEWEB)

Orwig, Kirsten D.; Hummon, Marissa; Hodge, Bri-Mathias; Lew, Debra [National Renewable Energy Laboratory, Golden, CO (United States)

2011-07-01

Renewable energy integration studies are frequently conducted to evaluate the impacts wind and solar power have on grid operations and planning. In the United States, these studies have historically been focused on wind energy integration. However, with the rapid deployment of large-scale and distributed solar power across the United States, and Hawaii, the interest in solar power variability and its impacts on the grid is increasing. To complete detailed integration studies, modeled power production of existing and future solar power deployments is necessary. This paper discusses some of the methods used to generate photovoltaic (PV) and concentrating solar power (CSP) production profiles for studies undertaken in the United States, evaluates the results, and compares the profiles with measured solar power production characteristics. (orig.)

Detection and volume estimation of embolic air in the middle cerebral artery using transcranial Doppler sonography.

Science.gov (United States)

Bunegin, L; Wahl, D; Albin, M S

1994-03-01

Cerebral embolism has been implicated in the development of cognitive and neurological deficits following bypass surgery. This study proposes methodology for estimating cerebral air embolus volume using transcranial Doppler sonography. Transcranial Doppler audio signals of air bubbles in the middle cerebral artery obtained from in vivo experiments were subjected to a fast-Fourier transform analysis. Audio segments when no air was present as well as artifact resulting from electrocautery and sensor movement were also subjected to fast-Fourier transform analysis. Spectra were compared, and frequency and power differences were noted and used for development of audio band-pass filters for isolation of frequencies associated with air emboli. In a bench model of the middle cerebral artery circulation, repetitive injections of various air volumes between 0.5 and 500 microL were made. Transcranial Doppler audio output was band-pass filtered, acquired digitally, then subjected to a fast-Fourier transform power spectrum analysis and power spectrum integration. A linear least-squares correlation was performed on the data. Fast-Fourier transform analysis of audio segments indicated that frequencies between 250 and 500 Hz are consistently dominant in the spectrum when air emboli are present. Background frequencies appear to be below 240 Hz, and artifact resulting from sensor movement and electrocautery appears to be below 300 Hz. Data from the middle cerebral artery model filtered through a 307- to 450-Hz band-pass filter yielded a linear relation between emboli volume and the integrated value of the power spectrum near 40 microL. Detection of emboli less than 0.5 microL was inconsistent, and embolus volumes greater than 40 microL were indistinguishable from one another. The preliminary technique described in this study may represent a starting point from which automated detection and volume estimation of cerebral emboli might be approached.

Study on magnetic field mapping within cylindrical center volume of general magnet

Energy Technology Data Exchange (ETDEWEB)

Huang, Li; Lee, Sang Jin [Uiduk University, Gyeongju (Korea, Republic of)

2016-06-15

For the magnetic field analysis or design, it is important to know the behavior of the magnetic field in an interesting space. Magnetic field mapping becomes a useful tool for the study of magnetic field. In this paper, a numerical way for mapping the magnetic field within the cylindrical center volume of magnet is presented, based on the solution of the Laplace's equation in the cylindrical coordinate system. The expression of the magnetic field can be obtained by the magnetic flux density, which measured in the mapped volume. According to the form of the expression, the measurement points are arranged with the parallel cylindrical line (PCL) method. As example, the magnetic flux density generated by an electron cyclotron resonance ion source (ECRIS) magnet and a quadrupole magnet were mapped using the PCL method, respectively. The mapping results show the PCL arrangement method is feasible and convenience to map the magnetic field within a cylindrical center volume generated by the general magnet.

MRI definition of target volumes using fuzzy logic method for three-dimensional conformal radiation therapy

International Nuclear Information System (INIS)

Caudrelier, Jean-Michel; Vial, Stephane; Gibon, David; Kulik, Carine; Fournier, Charles; Castelain, Bernard; Coche-Dequeant, Bernard; Rousseau, Jean

2003-01-01

Purpose: Three-dimensional (3D) volume determination is one of the most important problems in conformal radiation therapy. Techniques of volume determination from tomographic medical imaging are usually based on two-dimensional (2D) contour definition with the result dependent on the segmentation method used, as well as on the user's manual procedure. The goal of this work is to describe and evaluate a new method that reduces the inaccuracies generally observed in the 2D contour definition and 3D volume reconstruction process. Methods and Materials: This new method has been developed by integrating the fuzziness in the 3D volume definition. It first defines semiautomatically a minimal 2D contour on each slice that definitely contains the volume and a maximal 2D contour that definitely does not contain the volume. The fuzziness region in between is processed using possibility functions in possibility theory. A volume of voxels, including the membership degree to the target volume, is then created on each slice axis, taking into account the slice position and slice profile. A resulting fuzzy volume is obtained after data fusion between multiorientation slices. Different studies have been designed to evaluate and compare this new method of target volume reconstruction and a classical reconstruction method. First, target definition accuracy and robustness were studied on phantom targets. Second, intra- and interobserver variations were studied on radiosurgery clinical cases. Results: The absolute volume errors are less than or equal to 1.5% for phantom volumes calculated by the fuzzy logic method, whereas the values obtained with the classical method are much larger than the actual volumes (absolute volume errors up to 72%). With increasing MRI slice thickness (1 mm to 8 mm), the phantom volumes calculated by the classical method are increasing exponentially with a maximum absolute error up to 300%. In contrast, the absolute volume errors are less than 12% for phantom

Introduction to integrable many-body systems III

International Nuclear Information System (INIS)

Bajnok, Z.; Samaj, L.

2011-01-01

This is the third part of a three-volume introductory course about integrable systems of interacting bodies. The emphasis is put onto the method of Thermodynamic Bethe Ansatz. Two kinds of integrable models are studied. Systems of itinerant electrons, forming a part of Condensed Matter Physics, involve the Hubbard lattice model of electrons with short-ranged one-site interactions (Sect. 20) and the s-d exchange Kondo model (Sect. 21), describing the scattering of conduction electrons on a spin-s impurity. Methods and basic concepts used in Quantum Field Theory are explained on the integrable (1 + 1)-dimensional sine-Gordon model. We start with the classical description of the model in Sect. 22, analyze its finite energy field configurations (soliton, anti-soliton and breathers) and show its classical integrability. The model is quantized by using two schemes: the conformal (Sect. 23) and Lagrangian (Sect. 24) quantizations. The scattering matrix of the sine-Gordon theory is derived at the full quantum level in the bootstrap scheme and is compared to its classical limit in Sect. 25. The parameters of the scattering matrix are related to those of the Lagrangian by calculating the ground-state energy in an applied magnetic field in two ways: Conformal perturbation theory and Thermodynamic Bethe Ansatz (Sect. 26). The relation of the sine-Gordon theory to the XXZ Heisenberg model, which provides a complete solution of the sine-Gordon model in a finite volume, is pointed out in Sect. 27. The obtained results are applied in Sect. 28. to the derivation of the exact thermodynamics for the (symmetric) two-component Coulomb gas; this is the first classical two-dimensional fluid with exactly solvable thermodynamics (Authors)

A Stable Marching on-in-time Scheme for Solving the Time Domain Electric Field Volume Integral Equation on High-contrast Scatterers

KAUST Repository

Sayed, Sadeed Bin

2015-05-05

A time domain electric field volume integral equation (TD-EFVIE) solver is proposed for characterizing transient electromagnetic wave interactions on high-contrast dielectric scatterers. The TD-EFVIE is discretized using the Schaubert- Wilton-Glisson (SWG) and approximate prolate spherical wave (APSW) functions in space and time, respectively. The resulting system of equations can not be solved by a straightforward application of the marching on-in-time (MOT) scheme since the two-sided APSW interpolation functions require the knowledge of unknown “future” field samples during time marching. Causality of the MOT scheme is restored using an extrapolation technique that predicts the future samples from known “past” ones. Unlike the extrapolation techniques developed for MOT schemes that are used in solving time domain surface integral equations, this scheme trains the extrapolation coefficients using samples of exponentials with exponents on the complex frequency plane. This increases the stability of the MOT-TD-EFVIE solver significantly, since the temporal behavior of decaying and oscillating electromagnetic modes induced inside the scatterers is very accurately taken into account by this new extrapolation scheme. Numerical results demonstrate that the proposed MOT solver maintains its stability even when applied to analyzing wave interactions on high-contrast scatterers.

A Stable Marching on-in-time Scheme for Solving the Time Domain Electric Field Volume Integral Equation on High-contrast Scatterers

KAUST Repository

Sayed, Sadeed Bin; Ulku, Huseyin; Bagci, Hakan

2015-01-01

A time domain electric field volume integral equation (TD-EFVIE) solver is proposed for characterizing transient electromagnetic wave interactions on high-contrast dielectric scatterers. The TD-EFVIE is discretized using the Schaubert- Wilton-Glisson (SWG) and approximate prolate spherical wave (APSW) functions in space and time, respectively. The resulting system of equations can not be solved by a straightforward application of the marching on-in-time (MOT) scheme since the two-sided APSW interpolation functions require the knowledge of unknown “future” field samples during time marching. Causality of the MOT scheme is restored using an extrapolation technique that predicts the future samples from known “past” ones. Unlike the extrapolation techniques developed for MOT schemes that are used in solving time domain surface integral equations, this scheme trains the extrapolation coefficients using samples of exponentials with exponents on the complex frequency plane. This increases the stability of the MOT-TD-EFVIE solver significantly, since the temporal behavior of decaying and oscillating electromagnetic modes induced inside the scatterers is very accurately taken into account by this new extrapolation scheme. Numerical results demonstrate that the proposed MOT solver maintains its stability even when applied to analyzing wave interactions on high-contrast scatterers.

Integral dose investigation of non-coplanar treatment beam geometries in radiotherapy

Energy Technology Data Exchange (ETDEWEB)

Nguyen, Dan; Dong, Peng; Ruan, Dan; Low, Daniel A.; Sheng, Ke, E-mail: ksheng@mednet.ucla.edu [Department of Radiation Oncology, University of California, Los Angeles, California 90095 (United States); Long, Troy; Romeijn, Edwin [Department of Industrial and Operations, University of Michigan, Ann Arbor, Michigan 48109 (United States)

2014-01-15

Purpose: Automated planning and delivery of non-coplanar plans such as 4π radiotherapy involving a large number of fields have been developed to take advantage of the newly available automated couch and gantry on C-arm gantry linacs. However, there is an increasing concern regarding the potential changes in the integral dose that needs to be investigated. Methods: A digital torso phantom and 22 lung and liver stereotactic body radiation therapy (SBRT) patients were included in the study. The digital phantom was constructed as a water equivalent elliptical cylinder with a major axis length of 35.4 cm and minor axis of 23.6 cm. A 4.5 cm diameter target was positioned at varying depths along the major axis. Integral doses from intensity modulated, non-coplanar beams forming a conical pattern were compared against the equally spaced coplanar beam plans. Integral dose dependence on the phantom geometry and the beam number was also quantified. For the patient plans, the non-coplanar and coplanar beams and fluences were optimized using a column generation and pricing approach and compared against clinical VMAT plans using two full (lung) or partial coplanar arcs (liver) entering at the side proximal to the tumor. Both the average dose to the normal tissue volume and the total volumes receiving greater than 2 Gy (V2) and 5 Gy (V5) were evaluated and compared. Results: The ratio of integral dose from the non-coplanar and coplanar plans depended on the tumor depth for the phantom; for tumors shallower than 10 cm, the non-coplanar integral doses were lower than coplanar integral doses for non-coplanar angles less than 60°. Similar patterns were observed in the patient plans. The smallest non-coplanar integral doses were observed for tumor 6–8 cm deep. For the phantom, the integral dose was independent of the number of beams, consistent with the liver SBRT patients but the lung SBRT patients showed slight increase in the integral dose when more beams were used. Larger

Correlated volume-energy fluctuations of phospholipid membranes: A simulation study

DEFF Research Database (Denmark)

Pedersen, Ulf. R.; Peters, Günther H.J.; Schröder, Thomas B.

2010-01-01

This paper reports all-atom computer simulations of five phospholipid membranes (DMPC, DPPC, DMPG, DMPS, and DMPSH) with focus on the thermal equilibrium fluctuations of volume, energy, area, thickness, and chain order. At constant temperature and pressure, volume and energy exhibit strong...... membranes, showing a similar picture. The cause of the observed strong correlations is identified by splitting volume and energy into contributions from tails, heads, and water, and showing that the slow volume−energy fluctuations derive from van der Waals interactions of the tail region; they are thus...

Integrative production technology theory and applications

CERN Document Server

Özdemir, Denis

2017-01-01

This contributed volume contains the research results of the Cluster of Excellence “Integrative Production Technology for High-Wage Countries”, funded by the German Research Society (DFG). The approach to the topic is genuinely interdisciplinary, covering insights from fields such as engineering, material sciences, economics and social sciences. The book contains coherent deterministic models for integrative product creation chains as well as harmonized cybernetic models of production systems. The content is structured into five sections: Integrative Production Technology, Individualized Production, Virtual Production Systems, Integrated Technologies, Self-Optimizing Production Systems and Collaboration Productivity.The target audience primarily comprises research experts and practitioners in the field of production engineering, but the book may also be beneficial for graduate students. .

Effect of fluid loading on left ventricular volume and stroke volume variability in patients with end-stage renal disease: a pilot study

Science.gov (United States)

Kanda, Hirotsugu; Hirasaki, Yuji; Iida, Takafumi; Kanao-Kanda, Megumi; Toyama, Yuki; Kunisawa, Takayuki; Iwasaki, Hiroshi

2015-01-01

Purpose The aim of this study was to investigate fluid loading-induced changes in left ventricular end-diastolic volume (LVEDV) and stroke volume variability (SVV) in patients with end-stage renal disease (ESRD) using real-time three-dimensional transesophageal echocardiography and the Vigileo-FloTrac system. Patients and methods After obtaining ethics committee approval and informed consent, 28 patients undergoing peripheral vascular procedures were studied. Fourteen patients with ESRD on hemodialysis (HD) were assigned to the HD group and 14 patients without ESRD were assigned to the control group. Institutional standardized general anesthesia was provided in both groups. SVV was measured using the Vigileo-FloTrac system. Simultaneously, a full-volume three-dimensional transesophageal echocardiography dataset was acquired to measure LVEDV, left ventricular end-systolic volume, and left ventricular ejection fraction. Measurements were obtained before and after loading 500 mL hydroxyethyl starch over 30 minutes in both groups. Results In the control group, intravenous colloid infusion was associated with a significant decrease in SVV (13.8%±2.6% to 6.5%±2.6%, P<0.001) and a significant increase in LVEDV (83.6±23.4 mL to 96.1±28.8 mL, P<0.001). While SVV significantly decreased after infusion in the HD group (16.2%±6.0% to 6.2%±2.8%, P<0.001), there was no significant change in LVEDV. Conclusion Our preliminary data suggest that fluid responsiveness can be assessed not by LVEDV but also by SVV due to underlying cardiovascular pathophysiology in patients with ESRD. PMID:26527879

The Seabrook Conversion ''the volume reduction decision''

International Nuclear Information System (INIS)

Peters, R.W.; Kwasnik, J.; Strum, M.S.

1984-01-01

Radioactive Waste Management at commercial power facilities has come under extreme pressure to develop new process systems for the treatment of liquid and resin waste streams. This pressure arose from the elimination of all but three of the commercial radioactive waste burial sites, the increasing cost of transport and burial of the wastes and the elimination of urea-formaldehyde as an acceptable solidification agent. Nuclear plants (operating and under construction) have been forced to reassess their policies and programs regarding waste management. Seabrook Station under construction in Seabrook, New Hampshire, is no exception. Re-evaluation of the radwaste system at Seabrook and the subsequent choice of a new generation system took over three years to make. This paper presents a brief history of this effort and describes the system ultimately chosen as a replacement for the original urea-formaldehyde system. This integrated system features an asphalt extruder-evaporator, a forced circulation crystallizer-evaporator and a resin centrifuge to effect maximum volume reduction of both liquid and spent resin wastes. The full system also includes a supporting drum handling system to move drums throughout process and storage areas and a box compactor for DAW volume reduction. A single vendor was selected as prime contractor to supply this integrated radwaste plant. By choosing a single vendor as prime contractor, PSNH gained the added benefits of having a single contract to manage, uniformity in parts such as instrumentation and controls, and obtained an integrated system warranty

The world economy of petroleum products and the strategy of a petroleum company from exporting country: Cases of SONATRACH (Algeria), KPC (Kuwait), PEMEX (Mexico), PDVSA (Venezuela). Second volume

International Nuclear Information System (INIS)

Preure, M.

1992-12-01

This thesis contains 2 volumes. In this second volume, the author describes the industrial and technological developments and the strategy of petroleum companies in exporting countries. The main industrial strategies studied are national integration strategy in a planned economy (case of Algeria) or in a controlled-liberal economy (case of Mexico) and international integration strategies to the lower part of petroleum industry and external growth (cases of Kuwait and Venezuela). Technological strategies studied are development of a national engineering, information, research programs/ development and innovation. The last chapter takes stock of research and development programs for petroleum products (case of Mexico) . 258 refs., 103 tabs

Study of volume fractions on biphasic stratified regime using gamma ray

Energy Technology Data Exchange (ETDEWEB)

Salgado, William L.; Brandão, Luis E.B., E-mail: william.otero@hotmail.com, E-mail: brandao@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

2017-07-01

In the oil industries, interconnected pipelines are used to carry large quantities of petroleum and its byproducts. This modal has an advantage because they are more economical, eliminate a need for stocks and, in addition, great safety in operation minimizing a possibility of loss or theft when transported another way. In many cases, especially in the petrochemical industry, the same pipeline is used to carry more than one type of product. They are called poliduct. In the operation of a poliduct there is a sequence of products to be transported and during the exchange of the product, there are still fractions of the previous product and this generates contamination. It is therefore important to identify precisely this region in order to reduce the costs of reprocessing and treatment of discarded products. In this way, this work presents a methodology to evaluate the sensitivity of the gamma densitometry technique in a study of the calculation of volume fractions in biphasic systems, submitted to the stratified flow regime. Using computational simulations using the Monte Carlo Method with the MCNPX code measurement geometry was proposed that presented a higher sensitivity for the calculation of volume fractions. The relevant technical data to perform a simulation of the scintillator detectors were based on information obtained from the gammagraphy technique. The study had a theoretical validation through analytical equations, and the results show that it is possible to identify volume fractions equivalent to 3%. (author)

Study of volume fractions on biphasic stratified regime using gamma ray

International Nuclear Information System (INIS)

Salgado, William L.; Brandão, Luis E.B.

2017-01-01

In the oil industries, interconnected pipelines are used to carry large quantities of petroleum and its byproducts. This modal has an advantage because they are more economical, eliminate a need for stocks and, in addition, great safety in operation minimizing a possibility of loss or theft when transported another way. In many cases, especially in the petrochemical industry, the same pipeline is used to carry more than one type of product. They are called poliduct. In the operation of a poliduct there is a sequence of products to be transported and during the exchange of the product, there are still fractions of the previous product and this generates contamination. It is therefore important to identify precisely this region in order to reduce the costs of reprocessing and treatment of discarded products. In this way, this work presents a methodology to evaluate the sensitivity of the gamma densitometry technique in a study of the calculation of volume fractions in biphasic systems, submitted to the stratified flow regime. Using computational simulations using the Monte Carlo Method with the MCNPX code measurement geometry was proposed that presented a higher sensitivity for the calculation of volume fractions. The relevant technical data to perform a simulation of the scintillator detectors were based on information obtained from the gammagraphy technique. The study had a theoretical validation through analytical equations, and the results show that it is possible to identify volume fractions equivalent to 3%. (author)

High Quality Data for Grid Integration Studies

Energy Technology Data Exchange (ETDEWEB)

Clifton, Andrew; Draxl, Caroline; Sengupta, Manajit; Hodge, Bri-Mathias

2017-01-22

As variable renewable power penetration levels increase in power systems worldwide, renewable integration studies are crucial to ensure continued economic and reliable operation of the power grid. The existing electric grid infrastructure in the US in particular poses significant limitations on wind power expansion. In this presentation we will shed light on requirements for grid integration studies as far as wind and solar energy are concerned. Because wind and solar plants are strongly impacted by weather, high-resolution and high-quality weather data are required to drive power system simulations. Future data sets will have to push limits of numerical weather prediction to yield these high-resolution data sets, and wind data will have to be time-synchronized with solar data. Current wind and solar integration data sets are presented. The Wind Integration National Dataset (WIND) Toolkit is the largest and most complete grid integration data set publicly available to date. A meteorological data set, wind power production time series, and simulated forecasts created using the Weather Research and Forecasting Model run on a 2-km grid over the continental United States at a 5-min resolution is now publicly available for more than 126,000 land-based and offshore wind power production sites. The National Solar Radiation Database (NSRDB) is a similar high temporal- and spatial resolution database of 18 years of solar resource data for North America and India. The need for high-resolution weather data pushes modeling towards finer scales and closer synchronization. We also present how we anticipate such datasets developing in the future, their benefits, and the challenges with using and disseminating such large amounts of data.

Occipital Lobe Gray Matter Volume in Male Patients with Chronic Schizophrenia: A Quantitative MRI Study

Science.gov (United States)

Onitsuka, Toshiaki; McCarley, Robert W.; Kuroki, Noriomi; Dickey, Chandlee C.; Kubicki, Marek; Demeo, Susan S.; Frumin, Melissa; Kikinis, Ron; Jolesz, Ferenc A.; Shenton, Martha E.

2008-01-01

Schizophrenia is characterized by deficits in cognition as well as visual perception. There have, however, been few magnetic resonance imaging (MRI) studies of the occipital lobe as an anatomically defined region of interest in schizophrenia. To examine whether or not patients with chronic schizophrenia show occipital lobe volume abnormalities, we measured gray matter volumes for both the primary visual area (PVA) and the visual association areas (VAA) using MRI based neuroanatomical landmarks and three-dimensional information. PVA and VAA gray matter volumes were measured using high-spatial resolution MRI in 25 male patients diagnosed with chronic schizophrenia and in 28 male normal controls. Chronic schizophrenia patients showed reduced bilateral VAA gray matter volume (11%), compared with normal controls, whereas patients showed no group difference in PVA gray matter volume. These results suggest that reduced bilateral VAA may be a neurobiological substrate of some of the deficits observed in early visual processing in schizophrenia. PMID:17350226

Limiting volume with modern ventilators.

Science.gov (United States)

Wing, Thomas J; Haan, Lutana; Ashworth, Lonny J; Anderson, Jeff

2015-06-01

The acute respiratory distress syndrome (ARDS) network low tidal-volume study comparing tidal volumes of 12 ml/kg versus 6 ml/kg was published in 2000. The study was stopped early as data revealed a 22% relative reduction in mortality rate when using 6 ml/kg tidal volume. The current generation of critical care ventilators allows the tidal volume to be set during volume-targeted, assist/control (volume A/C); however, some ventilators include options that may prevent the tidal volume from being controlled. The purpose of this bench study was to evaluate the delivered tidal volume, when these options are active, in a spontaneously breathing lung model using an electronic breathing simulator. Four ventilators were evaluated: CareFusion AVEA (AVEA), Dräger Evita® XL (Evita XL), Covidien Puritan Bennett® 840(TM) (PB 840), and Maquet SERVO-i (SERVO-i). Each ventilator was connected to the Hans Rudolph Electronic Breathing Simulator at an amplitude of 0 cm H2O and then 10 cm H2O. All four ventilators were set to deliver volume A/C, tidal volume 400 ml, respiratory rate 20 bpm, positive end-expiratory pressure 5 cm H2O, peak flowrate 60 L/min. The displayed tidal volume was recorded for each ventilator at the above settings with additional options OFF and then ON. The AVEA has two options in volume A/C: demand breaths and V-sync. When activated, these options allow the patient to exceed the set tidal volume. When using the Evita XL, the option AutoFlow can be turned ON or OFF, and when this option is ON, the tidal volume may vary. The PB 840 does not have any additional options that affect volume delivery, and it maintains the set tidal volume regardless of patient effort. The SERVO-i's demand valve allows additional flow if the patient's inspiratory flowrate exceeds the set flowrate, increasing the delivered tidal volume; this option can be turned OFF with the latest software upgrade. Modern ventilators have an increasing number of optional settings. These settings may

To what extent do long-duration high-volume dam releases influence river–aquifer interactions? A case study in New South Wales, Australia

KAUST Repository

Graham, Peter W.

2014-11-20

Long-duration high-volume dam releases are unique anthropogenic events with no naturally occurring equivalents. The impact from such dam releases on a downstream Quaternary alluvial aquifer in New South Wales, Australia, is assessed. It is observed that long-duration (>26 days), high-volume dam releases (>8,000 ML/day average) result in significant variations in river–aquifer interactions. These variations include a flux from the river to the aquifer up to 6.3 m3/day per metre of bank (at distances of up to 330 m from the river bank), increased extent and volume of recharge/bank storage, and a long-term (>100 days) reversal of river–aquifer fluxes. In contrast, during lower-volume events (<2,000 ML/day average) the flux was directed from the aquifer to the river at rates of up to 1.6 m3/day per metre of bank. A groundwater-head prediction model was constructed and river–aquifer fluxes were calculated; however, predicted fluxes from this method showed poor correlation to fluxes calculated using actual groundwater heads. Long-duration high-volume dam releases have the potential to skew estimates of long-term aquifer resources and detrimentally alter the chemical and physical properties of phreatic aquifers flanking the river. The findings have ramifications for improved integrated management of dam systems and downstream aquifers.

Site Environmental Report for 2005 Volume I and Volume II

Energy Technology Data Exchange (ETDEWEB)

Ruggieri, Michael

2006-07-07

Each year, Ernest Orlando Lawrence Berkeley National Laboratory prepares an integrated report on its environmental programs to satisfy the requirements of United States Department of Energy Order 231.1A, ''Environment, Safety, and Health Reporting''. The ''Site Environmental Report for 2005'' summarizes Berkeley Lab's environmental management performance, presents environmental monitoring results, and describes significant programs for calendar year 2005. (Throughout this report, Ernest Orlando Lawrence Berkeley National Laboratory is referred to as ''Berkeley Lab'', ''the Laboratory'', ''Lawrence Berkeley National Laboratory'', and ''LBNL''.) The report is separated into two volumes. Volume I contains an overview of the Laboratory, the status of environmental programs, and summarized results from surveillance and monitoring activities. This year's Volume I text body is organized into an executive summary followed by six chapters. The report's structure has been reorganized this year, and it now includes a chapter devoted to environmental management system topics. Volume II contains individual data results from surveillance and monitoring activities. The ''Site Environmental Report'' is distributed by releasing it on the Web from the Berkeley Lab Environmental Services Group (ESG) home page, which is located at http://www.lbl.gov/ehs/esg/. Many of the documents cited in this report also are accessible from the ESG Web page. CD and printed copies of this Site Environmental Report are available upon request. The report follows the Laboratory's policy of using the International System of Units (SI), also known as the metric system of measurements. Whenever possible, results are also reported using the more conventional (non-SI) system of measurements, because the non-SI system is referenced by several current

Estimation of lung volume and pulmonary blood volume from radioisotopic images

International Nuclear Information System (INIS)

Kanazawa, Minoru

1989-01-01

Lung volume and pulmonary blood volume in man were estimated from the radioisotopic image using single photon emission computed tomography (SPECT). Six healthy volunteers were studied in a supine position with normal and altered lung volumes by applying continuous negative body-surface pressure (CNP) and by positive end-expiratory pressure (PEEP). 99m Tc labeled human serum albumin was administered as an aerosol to image the lungs. The CNP caused the diaphragm to be lowered and it increased the mean lung tissue volume obtained by SPECT from 3.09±0.49 l for baseline to 3.67±0.62 l for 10 cmH 2 O (p 2 O (p 2 O), respectively. The PEEP also increased the lung tissue volume to 3.68±0.68 l for 10 cmH 2 O as compared with the baseline (p 2 O PEEP. The lung tissue volume obtained by SPECT showed a positive correlation with functional residual capacity measured by the He dilution method (r=0.91, p 99m Tc-labeled red blood cells. The L/H ratio decreased after either the CNP or PEEP, suggesting a decrease in the blood volume per unit lung volume. However, it was suggested that the total pulmonary blood volume increased slightly either on the CNP (+7.4% for 10 cmH 2 O, p 2 O,p<0.05) when we extrapolated the L/H ratio to the whole lungs by multiplying the lung tissue volume obtained by SPECT. We concluded that SPECT could offer access to the estimation of lung volume and pulmonary blood volume in vivo. (author)

PET functional volume delineation: a robustness and repeatability study

International Nuclear Information System (INIS)

Hatt, Mathieu; Cheze-le Rest, Catherine; Albarghach, Nidal; Pradier, Olivier; Visvikis, Dimitris

2011-01-01

Current state-of-the-art algorithms for functional uptake volume segmentation in PET imaging consist of threshold-based approaches, whose parameters often require specific optimization for a given scanner and associated reconstruction algorithms. Different advanced image segmentation approaches previously proposed and extensively validated, such as among others fuzzy C-means (FCM) clustering, or fuzzy locally adaptive bayesian (FLAB) algorithm have the potential to improve the robustness of functional uptake volume measurements. The objective of this study was to investigate robustness and repeatability with respect to various scanner models, reconstruction algorithms and acquisition conditions. Robustness was evaluated using a series of IEC phantom acquisitions carried out on different PET/CT scanners (Philips Gemini and Gemini Time-of-Flight, Siemens Biograph and GE Discovery LS) with their associated reconstruction algorithms (RAMLA, TF MLEM, OSEM). A range of acquisition parameters (contrast, duration) and reconstruction parameters (voxel size) were considered for each scanner model, and the repeatability of each method was evaluated on simulated and clinical tumours and compared to manual delineation. For all the scanner models, acquisition parameters and reconstruction algorithms considered, the FLAB algorithm demonstrated higher robustness in delineation of the spheres with low mean errors (10%) and variability (5%), with respect to threshold-based methodologies and FCM. The repeatability provided by all segmentation algorithms considered was very high with a negligible variability of <5% in comparison to that associated with manual delineation (5-35%). The use of advanced image segmentation algorithms may not only allow high accuracy as previously demonstrated, but also provide a robust and repeatable tool to aid physicians as an initial guess in determining functional volumes in PET. (orig.)

Integration of equations of parabolic type by the method of nets

CERN Document Server

Saul'Yev, V K; Stark, M; Ulam, S

1964-01-01

International Series of Monographs in Pure and Applied Mathematics, Volume 54: Integration of Equations of Parabolic Type by the Method of Nets deals with solving parabolic partial differential equations using the method of nets. The first part of this volume focuses on the construction of net equations, with emphasis on the stability and accuracy of the approximating net equations. The method of nets or method of finite differences (used to define the corresponding numerical method in ordinary differential equations) is one of many different approximate methods of integration of partial diff

Phantom study on three-dimensional target volume delineation by PET/CT-based auto-contouring

International Nuclear Information System (INIS)

Zhang, Tiejiao; Sakaguchi, Yuichi; Mitsumoto, Katsuhiko; Mitsumoto, Tatsuya; Sasaki, Masayuki; Tachiya, Yosuke; Ohya, Nobuyoshi

2010-01-01

The aim of this study was to determine an appropriate threshold value for delineation of the target volume in positron emission tomography (PET)/CT and to investigate whether we could delineate a target volume by phantom studies. A phantom consisted of six spheres (φ10-37 mm) filled with 18 F solution. Data acquisition was performed PET/CT in non-motion and motion status with high 18 F solution and in non-motion status with low 18 F solution. In non-motion phantom experiments, we determined two types of threshold value, an absolute SUV (T SUV ) and a percentage of the maximum SUV (T % ). Delineation using threshold values was applied for all spheres and for selected large spheres (a diameter of 22 mm or larger). In motion phantom experiments, data acquisition was performed in a static mode (sPET) and a gated mode (gPET). CT scanning was performed with helical CT (HCT) and 4-dimentional CT (4DCT). The appropriate threshold values were aT % =27% and aT SUV =2.4 for all spheres, and sT % =30% and sT SUV =4.3 for selected spheres. For all spheres in sPET/HCT in motion, the delineated volumes were 84%-129% by the aT % and 34%-127% by the aT SUV . In gPET/4DCT in motion, the delineated volumes were 94-103% by the aT % and 51-131% by the aT SUV . For low radioactivity spheres, the delineated volumes were all underestimated. A threshold value of T % =27% was proposed for auto-contouring of lung tumors. Our results also suggested that the respiratory gated data acquisition should be performed in both PET and CT for target volume delineation. (author)

Case Studies in Environment Integration

Science.gov (United States)

1991-12-01

such as CADRE Teamwork and Frame Technology FrameMaker , are integrated. Future plans include integrating additional software development tools into...Pictures, Sabre C, and Interleaf or FrameMaker . Cad- re Technologies has announced integration agreements with Saber C and Pansophic, as well as offering...access to the Interleaf and FrameMaker documentation tools. While some of the current agreements between vendors to create tool coalitions are

Social Integration and Sleep Disturbance: A Gene-Environment Interaction Study

Directory of Open Access Journals (Sweden)

David A. Sbarra

2016-03-01

Full Text Available Objective: Low levels of perceived social integration, or loneliness, are associated with increased risk for a range of poor health outcomes. Sleep disturbance plays a central role in the evolutionary theory of loneliness, which provides a mechanistic account of how low levels of social integration may negatively impact health. No studies, however, have examined whether the association between social integration and sleep disturbance is consistent with a causal effect after accounting for genes that are common to both variables.  Method: Using twin data ('N' = 905 twin pairs from the nationally-representative Midlife in the United States (MIDUS survey, I evaluated a series of bivariate twin models exploring whether the phenotypic association between low social integration and sleep disturbance can be explained by shared genetics. In addition, the current study specified a series of quantitative models for studying gene x environment (G X E interactions to determine whether the genetic and environmental influences on sleep disturbance differ as a function of social integration. Results: The phenotypic association between social integration and sleep disturbance was fully accounted for by genes that are common between the two variables, suggesting that within-twin pair differences in social integration do not exert a causal influence on sleep disturbance. Social integration, however, moderated the non-shared environmental influence on sleep disturbances, with the greatest environmental influences observed at the lowest levels of social integration. Conclusions: The results of this study suggest that an essential feature of the evolutionary model of loneliness may need refinement or elaboration. The moderation findings are discussed in terms of the fit with a stress-buffering model of social support in which environmental influences on sleep disturbance are strongest when social resources are low.

Trade Integration Effects in ASEAN Countries

Directory of Open Access Journals (Sweden)

Yana Valeryevna Dyomina

2015-09-01

Full Text Available The paper examines evolution of trade integration process in ASEAN. The author employs three methods in order to evaluate the degree of ASEAN‘s trade integration that has been achieved over two decades since the signing of the Association of South-East Asian Nations Free Trade Area Agreement (AFTA in 1992. The high degree of trade integration among member states allows moving to the next stage of international economic integration (ASEAN countries are going to form ASEAN Community (the Common Market by the 1st of January 2016. So the study assesses the ASEAN’s preparedness to the Common Market by determining the share of mutual (intraregional trade, regional trade intensity index (RTII and trade integration effects (trade creation and trade diversion effects for each member state, 2 groups of ASEAN countries (ASEAN-6 and ASEAN-4 and the Association as a whole. The paper shows that despite the increase in the share of intraregional trade during the years of the AFTA functioning, the member states of ASEAN still demonstrate low levels of trade integration: a 75% of the Association’s external trade focuses on extra regional partners; b ASEAN as a whole has the low volume of RTII and among its member states only Singapore has the high one; c trade diversion effect prevails over trade creation one

Reconfigurable Integrated Optoelectronics

Directory of Open Access Journals (Sweden)

Richard Soref

2011-01-01

Full Text Available Integrated optics today is based upon chips of Si and InP. The future of this chip industry is probably contained in the thrust towards optoelectronic integrated circuits (OEICs and photonic integrated circuits (PICs manufactured in a high-volume foundry. We believe that reconfigurable OEICs and PICs, known as ROEICs and RPICs, constitute the ultimate embodiment of integrated photonics. This paper shows that any ROEIC-on-a-chip can be decomposed into photonic modules, some of them fixed and some of them changeable in function. Reconfiguration is provided by electrical control signals to the electro-optical building blocks. We illustrate these modules in detail and discuss 3D ROEIC chips for the highest-performance signal processing. We present examples of our module theory for RPIC optical lattice filters already constructed, and we propose new ROEICs for directed optical logic, large-scale matrix switching, and 2D beamsteering of a phased-array microwave antenna. In general, large-scale-integrated ROEICs will enable significant applications in computing, quantum computing, communications, learning, imaging, telepresence, sensing, RF/microwave photonics, information storage, cryptography, and data mining.

Robust isotropic super-resolution by maximizing a Laplace posterior for MRI volumes

Science.gov (United States)

Han, Xian-Hua; Iwamoto, Yutaro; Shiino, Akihiko; Chen, Yen-Wei

2014-03-01

Magnetic resonance imaging can only acquire volume data with finite resolution due to various factors. In particular, the resolution in one direction (such as the slice direction) is much lower than others (such as the in-plane direction), yielding un-realistic visualizations. This study explores to reconstruct MRI isotropic resolution volumes from three orthogonal scans. This proposed super- resolution reconstruction is formulated as a maximum a posterior (MAP) problem, which relies on the generation model of the acquired scans from the unknown high-resolution volumes. Generally, the deviation ensemble of the reconstructed high-resolution (HR) volume from the available LR ones in the MAP is represented as a Gaussian distribution, which usually results in some noise and artifacts in the reconstructed HR volume. Therefore, this paper investigates a robust super-resolution by formulating the deviation set as a Laplace distribution, which assumes sparsity in the deviation ensemble based on the possible insight of the appeared large values only around some unexpected regions. In addition, in order to achieve reliable HR MRI volume, we integrates the priors such as bilateral total variation (BTV) and non-local mean (NLM) into the proposed MAP framework for suppressing artifacts and enriching visual detail. We validate the proposed robust SR strategy using MRI mouse data with high-definition resolution in two direction and low-resolution in one direction, which are imaged in three orthogonal scans: axial, coronal and sagittal planes. Experiments verifies that the proposed strategy can achieve much better HR MRI volumes than the conventional MAP method even with very high-magnification factor: 10.

Integral Engine Inlet Particle Separator. Volume 2. Design Guide

Science.gov (United States)

1975-08-01

herein will be used in the design of integral inlet particle separators for future Army aircraft gas turbine engines. Apprupriate technical personnel...into the comprensor at some future date. 5. A typical scavenge vane design Js; shown in Figures 85 and 86. The important features of the scavenge...service passageweys, for cooling of oil, and for directing sand and air into the scroll. Orientetion of the vanes is set by collection efficiency

Free-volume study of ethylene - vinyl alcohol copolymer evaluated through positronium lifetime measurement

International Nuclear Information System (INIS)

Ito, K.; Hong-ling Li; Ujihira, Y.; Nomura, K.; Saito, Y.; Yamamoto, T.; Nishihara, Y.

2003-01-01

The free-volume, of size ranging from 0.2 to 0.4 nm in radius, in an ethylene-vinyl alcohol copolymer was estimated using positronium lifetime measurement to elucidate the dependence of oxygen permeability on the free-volume size and fraction, on the ethylene content and on the crystallinity. The permeability and the free-volume fraction with varying the ethylene content were well related and the relation was interpreted based on the free-volume theory near below and above the glass transition temperature. On the other hand, the crystallinity significantly influenced the fraction of the amorphous region, where the free-volume hole exists, along with a slight change of the free-volume size. The variation of the permeability with the crystalline degree cannot be explained from the averaged free-volume fraction estimated by the whole volume of the polymer, but the permeability correlated with the free-volume size apparently. (author)

NRC action plan developed as a result of the TMI-2 accident. Volume 2

International Nuclear Information System (INIS)

1980-05-01

The Action Plan provides a comprehensive and integrated plan for all actions judged necessary by the Nuclear Regulatory Commission to correct or improve the regulation and operation of nuclear facilities based on the experience from the accident at the Three Mile Island, Unit 2, nuclear facility and the official studies and investigations of the accident. The tables included in this volume list the recommendations from the various organizations and task forces investigating the accident at Three Mile Island. The tables are annotated to provide easy references to the associated parts of the Action Plan in Volume 1. The tables are also annotated to provide a shorthand indication of how the various recommendations are treated in the Action Plan

Human Integration Design Processes (HIDP)

Science.gov (United States)

Boyer, Jennifer

2014-01-01

The purpose of the Human Integration Design Processes (HIDP) document is to provide human-systems integration design processes, including methodologies and best practices that NASA has used to meet human systems and human rating requirements for developing crewed spacecraft. HIDP content is framed around human-centered design methodologies and processes in support of human-system integration requirements and human rating. NASA-STD-3001, Space Flight Human-System Standard, is a two-volume set of National Aeronautics and Space Administration (NASA) Agency-level standards established by the Office of the Chief Health and Medical Officer, directed at minimizing health and performance risks for flight crews in human space flight programs. Volume 1 of NASA-STD-3001, Crew Health, sets standards for fitness for duty, space flight permissible exposure limits, permissible outcome limits, levels of medical care, medical diagnosis, intervention, treatment and care, and countermeasures. Volume 2 of NASASTD- 3001, Human Factors, Habitability, and Environmental Health, focuses on human physical and cognitive capabilities and limitations and defines standards for spacecraft (including orbiters, habitats, and suits), internal environments, facilities, payloads, and related equipment, hardware, and software with which the crew interfaces during space operations. The NASA Procedural Requirements (NPR) 8705.2B, Human-Rating Requirements for Space Systems, specifies the Agency's human-rating processes, procedures, and requirements. The HIDP was written to share NASA's knowledge of processes directed toward achieving human certification of a spacecraft through implementation of human-systems integration requirements. Although the HIDP speaks directly to implementation of NASA-STD-3001 and NPR 8705.2B requirements, the human-centered design, evaluation, and design processes described in this document can be applied to any set of human-systems requirements and are independent of reference

Feasibility study on application of volume acid fracturing technology to tight gas carbonate reservoir development

Directory of Open Access Journals (Sweden)

Nianyin Li

2015-09-01

Full Text Available How to effectively develop tight-gas carbonate reservoir and achieve high recovery is always a problem for the oil and gas industry. To solve this problem, domestic petroleum engineers use the combination of the successful experiences of North American shale gas pools development by stimulated reservoir volume (SRV fracturing with the research achievements of Chinese tight gas development by acid fracturing to propose volume acid fracturing technology for fractured tight-gas carbonate reservoir, which has achieved a good stimulation effect in the pilot tests. To determine what reservoir conditions are suitable to carry out volume acid fracturing, this paper firstly introduces volume acid fracturing technology by giving the stimulation mechanism and technical ideas, and initially analyzes the feasibility by the comparison of reservoir characteristics of shale gas with tight-gas carbonate. Then, this paper analyzes the validity and limitation of the volume acid fracturing technology via the analyses of control conditions for volume acid fracturing in reservoir fracturing performance, natural fracture, horizontal principal stress difference, orientation of in-situ stress and natural fracture, and gives the solution for the limitation. The study results show that the volume acid fracturing process can be used to greatly improve the flow environment of tight-gas carbonate reservoir and increase production; the incremental or stimulation response is closely related with reservoir fracturing performance, the degree of development of natural fracture, the small intersection angle between hydraulic fracture and natural fracture, the large horizontal principal stress difference is easy to form a narrow fracture zone, and it is disadvantageous to create fracture network, but the degradable fiber diversion technology may largely weaken the disadvantage. The practices indicate that the application of volume acid fracturing process to the tight-gas carbonate

Patrick Air Force Base integrated resource assessment. Volume 3, Resource assessment

Energy Technology Data Exchange (ETDEWEB)

Sandusky, W.F.; Parker, S.A.; King, D.A.; Wahlstrom, R.R.; Elliott, D.B.; Shankle, S.A.

1993-12-01

The US Air Force has tasked the Pacific Northwest Laboratory (PNL) in support of the US Department of Energy Federal Energy Management Program to identify, evaluate, and assist in acquiring all cost effective energy projects at Patrick Air Force Base (AFB). This is part of a model program that PNL is designing to support energy-use decisions in the federal sector. This report provides the results of the fossil fuel and electric energy resource opportunity (ERO) assessments performed by PNL at Patrick AFB which is located south of Cocoa Beach, Florida. It is a companion report to Volume 1, Executive Summary, and Volume.2, Baseline Detail. The results of the analyses of EROs are presented in 11 common energy end-use categories. A narrative description of each ERO is provided, including information on the installed cost, energy and dollar savings, impacts on operations and maintenance, and, when applicable, a discussion of energy supply and demand, energy security, and environmental issues. A description of the evaluation methodologies and technical and cost assumptions is also provided for each ERO. Summary tables present the cost-effectiveness of energy end-use equipment before and after the implementation of each ERO and present the results of the life-cycle cost analysis indicating the net present value and value index of each ERO.

The formal path integral and quantum mechanics

International Nuclear Information System (INIS)

Johnson-Freyd, Theo

2010-01-01

Given an arbitrary Lagrangian function on R d and a choice of classical path, one can try to define Feynman's path integral supported near the classical path as a formal power series parameterized by 'Feynman diagrams', although these diagrams may diverge. We compute this expansion and show that it is (formally, if there are ultraviolet divergences) invariant under volume-preserving changes of coordinates. We prove that if the ultraviolet divergences cancel at each order, then our formal path integral satisfies a 'Fubini theorem' expressing the standard composition law for the time evolution operator in quantum mechanics. Moreover, we show that when the Lagrangian is inhomogeneous quadratic in velocity such that its homogeneous-quadratic part is given by a matrix with constant determinant, then the divergences cancel at each order. Thus, by 'cutting and pasting' and choosing volume-compatible local coordinates, our construction defines a Feynman-diagrammatic 'formal path integral' for the nonrelativistic quantum mechanics of a charged particle moving in a Riemannian manifold with an external electromagnetic field.

A Monte Carlo study of the impact of the choice of rectum volume definition on estimates of equivalent uniform doses and the volume parameter

International Nuclear Information System (INIS)

Kvinnsland, Yngve; Muren, Ludvig Paul; Dahl, Olav

2004-01-01

Calculations of normal tissue complication probability (NTCP) values for the rectum are difficult because it is a hollow, non-rigid, organ. Finding the true cumulative dose distribution for a number of treatment fractions requires a CT scan before each treatment fraction. This is labour intensive, and several surrogate distributions have therefore been suggested, such as dose wall histograms, dose surface histograms and histograms for the solid rectum, with and without margins. In this study, a Monte Carlo method is used to investigate the relationships between the cumulative dose distributions based on all treatment fractions and the above-mentioned histograms that are based on one CT scan only, in terms of equivalent uniform dose. Furthermore, the effect of a specific choice of histogram on estimates of the volume parameter of the probit NTCP model was investigated. It was found that the solid rectum and the rectum wall histograms (without margins) gave equivalent uniform doses with an expected value close to the values calculated from the cumulative dose distributions in the rectum wall. With the number of patients available in this study the standard deviations of the estimates of the volume parameter were large, and it was not possible to decide which volume gave the best estimates of the volume parameter, but there were distinct differences in the mean values of the values obtained

Combining 3d Volume and Mesh Models for Representing Complicated Heritage Buildings

Science.gov (United States)

Tsai, F.; Chang, H.; Lin, Y.-W.

2017-08-01

This study developed a simple but effective strategy to combine 3D volume and mesh models for representing complicated heritage buildings and structures. The idea is to seamlessly integrate 3D parametric or polyhedral models and mesh-based digital surfaces to generate a hybrid 3D model that can take advantages of both modeling methods. The proposed hybrid model generation framework is separated into three phases. Firstly, after acquiring or generating 3D point clouds of the target, these 3D points are partitioned into different groups. Secondly, a parametric or polyhedral model of each group is generated based on plane and surface fitting algorithms to represent the basic structure of that region. A "bare-bones" model of the target can subsequently be constructed by connecting all 3D volume element models. In the third phase, the constructed bare-bones model is used as a mask to remove points enclosed by the bare-bones model from the original point clouds. The remaining points are then connected to form 3D surface mesh patches. The boundary points of each surface patch are identified and these boundary points are projected onto the surfaces of the bare-bones model. Finally, new meshes are created to connect the projected points and original mesh boundaries to integrate the mesh surfaces with the 3D volume model. The proposed method was applied to an open-source point cloud data set and point clouds of a local historical structure. Preliminary results indicated that the reconstructed hybrid models using the proposed method can retain both fundamental 3D volume characteristics and accurate geometric appearance with fine details. The reconstructed hybrid models can also be used to represent targets in different levels of detail according to user and system requirements in different applications.

Reduced striatal volumes in Parkinson’s disease: a magnetic resonance imaging study

Directory of Open Access Journals (Sweden)

Pitcher Toni L

2012-08-01

Full Text Available Abstract Background The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease (PD is still poorly understood. Methods High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined. Putamen, caudate, and intracranial volumes were manually traced in the axial plane of 3D reconstructed images. Striatal nuclei volumes were normalized to intracranial volume for statistical comparison. Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale. Cognitive status was assessed using global status tests and detailed neuropsychological testing. Results Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender. Caudate volumes were reduced by 11% (p = 0.001 and putamen volumes by 8.1% (p = 0.025. PD striatal volumes were not found to be significantly correlated with cognitive or motor decline. Conclusion Small, but significant reductions in the volume of both the caudate and putamen occur in PD brains. These reductions are independent of the effects of age and gender, however the relation of these reductions to the functional loss of dopamine, which is characteristic of PD, remains unclear.

Experimental studies for the development of a new method for stroke volume measuring using X-ray videodensitometry

International Nuclear Information System (INIS)

Odenthal, H.J.

1982-01-01

Quantitative videodensitometry was studied with a view to its possible application as a new, non-invasive method of measuring cardiac stroke volume. To begin with, the accuracy of roentgen volumetric measurements was determined. After this, blood volume variations were measured by densitometry in five animal experiments. The findings were compared with the volumes measured by a flowmeter in the pulmonary artery. The total stroke volume was found to be proportional to the difference between the maximum and mean densitometric volume. A comparison between videodensitometry and other non-invasive methods showed that, in a stable circulatory system, the results of videodensitometry are equally reliable as, or even more reliable than, those of the conventional methods. (orig./MG) [de

Volume calculation from limited number of MR imaging sections

International Nuclear Information System (INIS)

Wang, J.; Mezrich, R.; Sebok, D.

1988-01-01

Magnetic resonance imaging is an accurate and noninvasive way to obtain cardiac geometrical information. For the quantification of left ventricular dynamic parameters, sections are taken along the long axis of the ventricle. Due to the limited number of sections that can be obtained in a reasonable amount of scanning time, the estimation of longitudinal dimension is usually the cause of error in volume calculation. The starting and ending sections are best estimated by guidance of the short axis cuts. This can only guarantee first-order accuracy. Simpson's rule for summation of areas to calculate volume, which is the commonly used method, assumes an accurate knowledge of the starting and ending points of integration. When this assumption is not perfectly met, Simpson's rule tends to unsystemically over- or underestimate the true volume. Due to this concern, some researchers adopt the images from the short axis cut to aid the volume calculation. This can improve the accuracy, but makes the already long scanning time longer. The authors have derived a method of extrapolation and intrapolation based on no more information than usually available to correct the volume over- or underestimated by the Simpson's rule