WorldWideScience

Sample records for integrating patient generated

  1. Generation and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease.

    Science.gov (United States)

    Son, Mi-Young; Lee, Mi-Ok; Jeon, Hyejin; Seol, Binna; Kim, Jung Hwa; Chang, Jae-Suk; Cho, Yee Sook

    2016-05-13

    Autoimmune diseases (AIDs), a heterogeneous group of immune-mediated disorders, are a major and growing health problem. Although AIDs are currently treated primarily with anti-inflammatory and immunosuppressive drugs, the use of stem cell transplantation in patients with AIDs is becoming increasingly common. However, stem cell transplantation therapy has limitations, including a shortage of available stem cells and immune rejection of cells from nonautologous sources. Induced pluripotent stem cell (iPSC) technology, which allows the generation of patient-specific pluripotent stem cells, could offer an alternative source for clinical applications of stem cell therapies in AID patients. We used nonintegrating oriP/EBNA-1-based episomal vectors to reprogram dermal fibroblasts from patients with AIDs such as ankylosing spondylitis (AS), Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). The pluripotency and multilineage differentiation capacity of each patient-specific iPSC line was validated. The safety of these iPSCs for use in stem cell transplantation is indicated by the fact that all AID-specific iPSCs are integrated transgene free. Finally, all AID-specific iPSCs derived in this study could be differentiated into cells of hematopoietic and mesenchymal lineages in vitro as shown by flow cytometric analysis and induction of terminal differentiation potential. Our results demonstrate the successful generation of integration-free iPSCs from patients with AS, SS and SLE. These findings support the possibility of using iPSC technology in autologous and allogeneic cell replacement therapy for various AIDs, including AS, SS and SLE.

  2. The Healthcare Future for the iGeneration: Integrating the Patient and the Healthcare System

    OpenAIRE

    Cathy H. Ficzere, PharmD, BCPS; Traci M. Poole, PharmD, BCACP; Rachel B. Franks, PharmD, BCACP; Elisa M. Greene, PharmD, BCACP; Kristina D. Wood, PharmD, BCACP; Philip E. Johnston, PharmD

    2013-01-01

    Objective: To propose a vision to integrate patients, their health-related data, and their wellness plans into the healthcare system using smartphone and tablet computer technology.Setting: Ambulatory care and community practicePractice Innovation: Utilization of smartphone and tablet computer technology to assess health care conditions, educate and involve patients, and facilitate seamless communication between the patient, electronic health record, pharmacy system, third-party payers, point...

  3. Generation of integration-free induced pluripotent stem cells from a patient with Familial Mediterranean Fever (FMF

    Directory of Open Access Journals (Sweden)

    Kerem Fidan

    2015-11-01

    Full Text Available Fibroblasts from a Familial Mediterranean Fever (FMF patient were reprogrammed with episomal vectors by using the Neon Transfection System for the generation of integration-free induced pluripotent stem cells (iPSCs. The resulting iPSC line was characterized to determine the expression of pluripotency markers, proper differentiation into three germ layers, the presence of normal chromosomal structures as well as the lack of genomic integration. A homozygous missense mutation in the MEFV gene (p.Met694Val, which lead to typical FMF phenotype, was shown to be present in the generated iPSC line.

  4. Generation of integration-free induced pluripotent stem cells from a patient with Familial Mediterranean Fever (FMF).

    Science.gov (United States)

    Fidan, Kerem; Kavaklıoğlu, Gülnihal; Ebrahimi, Ayyub; Özlü, Can; Ay, Nur Zeynep; Ruacan, Arzu; Gül, Ahmet; Önder, Tamer T

    2015-11-01

    Fibroblasts from a Familial Mediterranean Fever (FMF) patient were reprogrammed with episomal vectors by using the Neon Transfection System for the generation of integration-free induced pluripotent stem cells (iPSCs). The resulting iPSC line was characterized to determine the expression of pluripotency markers, proper differentiation into three germ layers, the presence of normal chromosomal structures as well as the lack of genomic integration. A homozygous missense mutation in the MEFV gene (p.Met694Val), which lead to typical FMF phenotype, was shown to be present in the generated iPSC line. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

  5. The Healthcare Future for the iGeneration: Integrating the Patient and the Healthcare System

    Directory of Open Access Journals (Sweden)

    Cathy H. Ficzere, PharmD, BCPS

    2013-01-01

    Full Text Available Objective: To propose a vision to integrate patients, their health-related data, and their wellness plans into the healthcare system using smartphone and tablet computer technology.Setting: Ambulatory care and community practicePractice Innovation: Utilization of smartphone and tablet computer technology to assess health care conditions, educate and involve patients, and facilitate seamless communication between the patient, electronic health record, pharmacy system, third-party payers, point-of-care testing, and all health-care providers.Main Outcome Measures: By providing integrated and customized information at the point of use, medication adherence and access to care will be increased and patients will engage in healthy behaviors more often resulting in an improved level of care for patients.Results: In the future, the authors believe if the vision is achieved, the health care system and patients will see improved health outcomes and more efficient utilization of the healthcare system.Conclusions: Our proposed use of technology provides an opportunity to empower patients to positively improve their own health which could be a vital advancement in health care, especially in the areas of medication adherence, improving access to care, and health behavior support. As pharmacists, we may also embrace technology opportunities to expand our roles as health care professionals as we continue to partner with patients and the health care team to improve outcomes.

  6. Generation of iPS cell lines from schizophrenia patients using a non-integrative method

    Directory of Open Access Journals (Sweden)

    Jaroslaw Sochacki

    2016-07-01

    Full Text Available Skin biopsies were collected from three male patients (age 45, 44 and 44 with clinically diagnosed schizophrenia. The patients were diagnosed according to DSM-5 criteria by a trained psychiatrist. Dermal fibroblast cell lines were established and expanded for subsequent reprogramming procedures. Induced pluripotent stem (iPS cells were derived using the integration-free CytoTune®-iPS 2.0 Sendai Reprogramming Kit, containing Sendai virus particles of the four Yamanaka factors Oct3/4, Sox2, Klf4 and c-Myc.

  7. Steam generator tube integrity program

    Energy Technology Data Exchange (ETDEWEB)

    Dierks, D.R.; Shack, W.J. [Argonne National Laboratory, IL (United States); Muscara, J.

    1996-03-01

    A new research program on steam generator tubing degradation is being sponsored by the U.S. Nuclear Regulatory Commission (NRC) at Argonne National Laboratory. This program is intended to support a performance-based steam generator tube integrity rule. Critical areas addressed by the program include evaluation of the processes used for the in-service inspection of steam generator tubes and recommendations for improving the reliability and accuracy of inspections; validation and improvement of correlations for evaluating integrity and leakage of degraded steam generator tubes, and validation and improvement of correlations and models for predicting degradation in steam generator tubes as aging occurs. The studies will focus on mill-annealed Alloy 600 tubing, however, tests will also be performed on replacement materials such as thermally-treated Alloy 600 or 690. An overview of the technical work planned for the program is given.

  8. Generation of integration free induced pluripotent stem cells from fibrodysplasia ossificans progressiva (FOP) patients from urine samples.

    Science.gov (United States)

    Hildebrand, Laura; Rossbach, Bella; Kühnen, Peter; Gossen, Manfred; Kurtz, Andreas; Reinke, Petra; Seemann, Petra; Stachelscheid, Harald

    2016-01-01

    Fibrodysplasia ossificans progressiva (FOP) is an extremely rare, autosomal dominant transmitted genetic disease. Patients experience progressive bone formation replacing tendons, ligaments, muscle and soft tissue. Cause of FOP are gain-of-function mutations in the Bone Morphogenetic Protein (BMP) receptor Activin A receptor type 1 (ACVR1) (Kaplan et al., 2008). The most common mutation is R206H, which leads to the substitution of codon 206 from arginine to histidine (Shore et al., 2006). Here, we describe the derivation and characterization of two hiPSC lines from two FOP patients, both carrying the mutation R206H. Cells were isolated from urine and reprogrammed using integration free Sendai virus vectors under defined conditions.

  9. Eastern Renewable Generation Integration Study

    Energy Technology Data Exchange (ETDEWEB)

    Bloom, Aaron [National Renewable Energy Lab. (NREL), Golden, CO (United States); Townsend, Aaron [National Renewable Energy Lab. (NREL), Golden, CO (United States); Palchak, David [National Renewable Energy Lab. (NREL), Golden, CO (United States); Novacheck, Joshua [National Renewable Energy Lab. (NREL), Golden, CO (United States); King, Jack [RePPAE LLC, Wexford, PA (United States); Barrows, Clayton [National Renewable Energy Lab. (NREL), Golden, CO (United States); Ibanez, Eduardo [GE Energy, Denver, CO (United States); O' Connell, Matthew [National Renewable Energy Lab. (NREL), Golden, CO (United States); Jordan, Gary [GE Energy, Denver, CO (United States); Roberts, Billy [National Renewable Energy Lab. (NREL), Golden, CO (United States); Draxl, Caroline [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gruchalla, Kenny [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-08-01

    The Eastern Interconnection (EI) is one of the largest power systems in the world, and its size and complexity have historically made it difficult to study in high levels of detail in a modeling environment. In order to understand how this system might be impacted by high penetrations (30% of total annual generation) of wind and solar photovoltaic (PV) during steady state operations, the National Renewable Energy Laboratory (NREL) and the U.S. Department of Energy (DOE) conducted the Eastern Renewable Generation Integration Study (ERGIS). This study investigates certain aspects of the reliability and economic efficiency problem faced by power system operators and planners. Specifically, the study models the ability to meet electricity demand at a 5-minute time interval by scheduling resources for known ramping events, while maintaining adequate reserves to meet random variation in supply and demand, and contingency events. To measure the ability to meet these requirements, a unit commitment and economic dispatch (UC&ED) model is employed to simulate power system operations. The economic costs of managing this system are presented using production costs, a traditional UC&ED metric that does not include any consideration of long-term fixed costs. ERGIS simulated one year of power system operations to understand regional and sub-hourly impacts of wind and PV by developing a comprehensive UC&ED model of the EI. In the analysis, it is shown that, under the study assumptions, generation from approximately 400 GW of combined wind and PV capacity can be balanced on the transmission system at a 5-minute level. In order to address the significant computational burdens associated with a model of this detail we apply novel computing techniques to dramatically reduce simulation solve time while simultaneously increasing the resolution and fidelity of the analysis. Our results also indicate that high penetrations of wind and PV (collectively variable generation (VG

  10. Review of Variable Generation Integration Charges

    Energy Technology Data Exchange (ETDEWEB)

    Porter, K.; Fink, S.; Buckley, M.; Rogers, J.; Hodge, B. M.

    2013-03-01

    The growth of wind and solar generation in the United States, and the expectation of continued growth of these technologies, dictates that the future power system will be operated in a somewhat different manner because of increased variability and uncertainty. A small number of balancing authorities have attempted to determine an 'integration cost' to account for these changes to their current operating practices. Some balancing authorities directly charge wind and solar generators for integration charges, whereas others add integration charges to projected costs of wind and solar in integrated resource plans or in competitive solicitations for generation. This report reviews the balancing authorities that have calculated variable generation integration charges and broadly compares and contrasts the methodologies they used to determine their specific integration charges. The report also profiles each balancing authority and how they derived wind and solar integration charges.

  11. Integration of stochastic generation in power systems

    NARCIS (Netherlands)

    Papaefthymiou, G.

    2007-01-01

    Stochastic Generation is the electrical power production by the use of an uncontrollable prime energy mover, corresponding mainly to renewable energy sources. For the large-scale integration of stochastic generation in power systems, methods are necessary for the modeling of power generation

  12. Integration of stochastic generation in power systems

    NARCIS (Netherlands)

    Papaefthymiou, G.

    2007-01-01

    Stochastic Generation is the electrical power production by the use of an uncontrollable prime energy mover, corresponding mainly to renewable energy sources. For the large-scale integration of stochastic generation in power systems, methods are necessary for the modeling of power generation uncerta

  13. Integration of stochastic generation in power systems

    NARCIS (Netherlands)

    Papaefthymiou, G.

    2007-01-01

    Stochastic Generation is the electrical power production by the use of an uncontrollable prime energy mover, corresponding mainly to renewable energy sources. For the large-scale integration of stochastic generation in power systems, methods are necessary for the modeling of power generation uncerta

  14. Generation Expansion Planning Considering Integrating Large-scale Wind Generation

    DEFF Research Database (Denmark)

    Zhang, Chunyu; Ding, Yi; Østergaard, Jacob

    2013-01-01

    Generation expansion planning (GEP) is the problem of finding the optimal strategy to plan the Construction of new generation while satisfying technical and economical constraints. In the deregulated and competitive environment, large-scale integration of wind generation (WG) in power system has...... necessitated the inclusion of more innovative and sophisticated approaches in power system investment planning. A bi-level generation expansion planning approach considering large-scale wind generation was proposed in this paper. The first phase is investment decision, while the second phase is production...

  15. Integral Compressor/Generator/Fan Unitary Structure

    OpenAIRE

    Dreiman, Nelik

    2016-01-01

    INTEGRAL COMPRESSOR / GENERATOR / FAN UNITARY STRUCTURE.*) Dr. Nelik Dreiman Consultant, P.O.Box 144, Tipton, MI E-mail: An extremely compact, therefore space saving single compressor/generator/cooling fan structure of short axial length and light weight has been developed to provide generation of electrical power with simultaneous operation of the compressor when power is unavailable or function as a regular AC compressor powered by a power line. The generators and ai...

  16. LC Quadrature Generation in Integrated Circuits

    DEFF Research Database (Denmark)

    Christensen, Kåre Tais

    2001-01-01

    Today quadrature signals for IQ demodulation are provided through RC polyphase networks, quadrature oscillators or double frequency VCOs. This paper presents a new method for generating quadrature signals in integrated circuits using only inductors and capacitors. This LC quadrature generation me...

  17. Kite Generator System: Grid Integration and Validation

    OpenAIRE

    Ahmed, Mariam; Hably, Ahmad; Bacha, Seddik; Ovalle, Andres

    2014-01-01

    International audience; In this paper, the problem of grid integration of a kite generator system (KGS), is handled. The mechanical power generated by the kite's traction is translated into an electrical one via a permanent magnet synchronous machine. This power is then injected in the grid or used to supply an isolated load after passing a power electronics interface. Control schemes have been developed for grid connected or stand-alone operation and tested on a hardware-in-the-loop simulator.

  18. Generative inspection process planner for integrated production

    Energy Technology Data Exchange (ETDEWEB)

    Brown, C.W. (Allied-Signal Aerospace Co., Kansas City, MO (USA). Kansas City Div.); Gyorog, D.A. (Kansas Univ., Lawrence, KS (USA). Dept. of Mechanical Engineering)

    1990-04-01

    This work describes the design prototype development of a generative process planning system for dimensional inspection. The system, IPPEX (Inspection Process Planning EXpert), is a rule-based expert system for integrated production. Using as advanced product modeler, relational databases, and artificial intelligence techniques, IPPEX generates the process plan and part program for the dimensional inspection of products using CMMs. Through an application interface, the IPPEX system software accesses product definition from the product modeler. The modeler is a solid geometric modeler coupled with a dimension and tolerance modeler. Resource data regarding the machines, probes, and fixtures are queried from databases. IPPEX represents inspection process knowledge as production rules and incorporates an embedded inference engine to perform decision making. The IPPEX system, its functional architecture, system architecture, system approach, product modeling environment, inspection features, inspection knowledge, hierarchical planning strategy, user interface formats, and other fundamental issues related to inspection planning and part programming for CMMs are described. 27 refs., 16 figs., 4 tabs.

  19. Integrated multi vector vortex beam generator

    CERN Document Server

    Schulz, Sebastian A; Karimi, Ebrahim; Boyd, Robert W

    2013-01-01

    A novel method to generate and manipulate vector vortex beams in an integrated, ring resonator based geometry is proposed. We show numerically that a ring resonator, with an appropriate grating, addressed by a vertically displaced access waveguide emits a complex optical field. The emitted beam possesses a specific polarization topology, and consequently a transverse intensity profile and orbital angular momentum. We propose a combination of several concentric ring resonators, addressed with different bus guides, to generate arbitrary orbital angular momentum qudit states, which could potentially be used for classical and quantum communications. Finally, we demonstrate numerically that this device works as an orbital angular momentum sorter with an average cross-talk of -10 dB between different orbital angular momentum channels.

  20. Integrated, Automated Distributed Generation Technologies Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Kevin

    2014-09-30

    The purpose of the NETL Project was to develop a diverse combination of distributed renewable generation technologies and controls and demonstrate how the renewable generation could help manage substation peak demand at the ATK Promontory plant site. The Promontory plant site is located in the northwestern Utah desert approximately 25 miles west of Brigham City, Utah. The plant encompasses 20,000 acres and has over 500 buildings. The ATK Promontory plant primarily manufactures solid propellant rocket motors for both commercial and government launch systems. The original project objectives focused on distributed generation; a 100 kW (kilowatt) wind turbine, a 100 kW new technology waste heat generation unit, a 500 kW energy storage system, and an intelligent system-wide automation system to monitor and control the renewable energy devices then release the stored energy during the peak demand time. The original goal was to reduce peak demand from the electrical utility company, Rocky Mountain Power (RMP), by 3.4%. For a period of time we also sought to integrate our energy storage requirements with a flywheel storage system (500 kW) proposed for the Promontory/RMP Substation. Ultimately the flywheel storage system could not meet our project timetable, so the storage requirement was switched to a battery storage system (300 kW.) A secondary objective was to design/install a bi-directional customer/utility gateway application for real-time visibility and communications between RMP, and ATK. This objective was not achieved because of technical issues with RMP, ATK Information Technology Department’s stringent requirements based on being a rocket motor manufacturing facility, and budget constraints. Of the original objectives, the following were achieved: • Installation of a 100 kW wind turbine. • Installation of a 300 kW battery storage system. • Integrated control system installed to offset electrical demand by releasing stored energy from renewable sources

  1. Integrated, Automated Distributed Generation Technologies Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Kevin [Atk Launch Systems Inc., Brigham City, UT (United States)

    2014-09-01

    The purpose of the NETL Project was to develop a diverse combination of distributed renewable generation technologies and controls and demonstrate how the renewable generation could help manage substation peak demand at the ATK Promontory plant site. The Promontory plant site is located in the northwestern Utah desert approximately 25 miles west of Brigham City, Utah. The plant encompasses 20,000 acres and has over 500 buildings. The ATK Promontory plant primarily manufactures solid propellant rocket motors for both commercial and government launch systems. The original project objectives focused on distributed generation; a 100 kW (kilowatt) wind turbine, a 100 kW new technology waste heat generation unit, a 500 kW energy storage system, and an intelligent system-wide automation system to monitor and control the renewable energy devices then release the stored energy during the peak demand time. The original goal was to reduce peak demand from the electrical utility company, Rocky Mountain Power (RMP), by 3.4%. For a period of time we also sought to integrate our energy storage requirements with a flywheel storage system (500 kW) proposed for the Promontory/RMP Substation. Ultimately the flywheel storage system could not meet our project timetable, so the storage requirement was switched to a battery storage system (300 kW.) A secondary objective was to design/install a bi-directional customer/utility gateway application for real-time visibility and communications between RMP, and ATK. This objective was not achieved because of technical issues with RMP, ATK Information Technology Department’s stringent requirements based on being a rocket motor manufacturing facility, and budget constraints. Of the original objectives, the following were achieved: • Installation of a 100 kW wind turbine. • Installation of a 300 kW battery storage system. • Integrated control system installed to offset electrical demand by releasing stored energy from renewable sources

  2. Emission & Generation Resource Integrated Database (eGRID)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Emissions & Generation Resource Integrated Database (eGRID) is an integrated source of data on environmental characteristics of electric power generation....

  3. Integrative cancer epidemiology--the next generation.

    Science.gov (United States)

    Spitz, Margaret R; Caporaso, Neil E; Sellers, Thomas A

    2012-12-01

    We outline an integrative approach to extend the boundaries of molecular cancer epidemiology by integrating modern and rapidly evolving "omics" technologies into state-of-the-art molecular epidemiology. In this way, one can comprehensively explore the mechanistic underpinnings of epidemiologic observations in cancer risk and outcome. We highlight the exciting opportunities to collaborate across large observational studies and to forge new interdisciplinary collaborative ventures.

  4. Integrative Cancer Epidemiology - The Next Generation

    Science.gov (United States)

    Spitz, Margaret R.; Caporaso, Neil E.; Sellers, Thomas A.

    2012-01-01

    Summary We outline an integrative approach to extend the boundaries of molecular cancer epidemiology by integrating modern and rapidly evolving “omics” technologies into state-of-the-art molecular epidemiology. In this way, one can comprehensively explore the mechanistic underpinnings of epidemiologic observations into cancer risk and outcome. We highlight the exciting opportunities to collaborate across large observational studies and to forge new interdisciplinary collaborative ventures. PMID:23230187

  5. Status of steam generator tubing integrity at Jaslovske Bohunice NPP

    Energy Technology Data Exchange (ETDEWEB)

    Cepcek, S. [Nuclear Regulatory Authority of the Slovak Republic, Trnava (Slovakia)

    1997-02-01

    Steam generator represents one of the most important component of nuclear power plants. Especially, loss of tubing integrity of steam generators can lead to the primary coolant leak to secondary circuit and in worse cases to the unit shut down or to the PTS events occurrence. Therefore, to ensure the steam generator tubing integrity and the current knowledge about tube degradation propagation and development is of the highest importance. In this paper the present status of steam generator tubing integrity in operated NPP in Slovak Republic is presented.

  6. Generating Object Descriptions: Integrating Examples with Text

    Science.gov (United States)

    1993-01-01

    generate prompts. The first goal of generating a LIST of atoms can be collapsed with the previ- [ Bruner , 19661 Jerome S . Bruner . Toward a Theory of in... Educational Psychology, 67:852-859, 1975. [Tennyson et al., 19751 Robert D. Tennyson, M. Steve, and S R. Boutwell. Instance Sequence and Analysis of Instance...Attribute Representation in Concept Acquisition. Journal of Educational Psychology, 67:821-827, 1975. [Touretzky, 19841 David S . Touretzky. UISP: A

  7. Integration of Renewable Generation in Power System Defence Plans

    DEFF Research Database (Denmark)

    Das, Kaushik

    , one of them being the North East area with high share of wind power generation.The aim of this study is to investigate how renewable generations like wind power can contribute to the power system defence plans. This PhD project “Integration of Renewable Generation in Power System Defence Plans...

  8. Integrated control of next generation power system

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2010-02-28

    The multi-agent system (MAS) approach has been applied with promising results for enhancing an electric power distribution circuit, such as the Circuit of the Future as developed by Southern California Edison. These next generation power system results include better ability to reconfigure the circuit as well as the increased capability to improve the protection and enhance the reliability of the circuit. There were four main tasks in this project. The specific results for each of these four tasks and their related topics are presented in main sections of this report. Also, there were seven deliverables for this project. The main conclusions for these deliverables are summarized in the identified subtask section of this report. The specific details for each of these deliverables are included in the “Project Deliverables” section at the end of this Final Report.

  9. Quantum Degrees of Freedom, Quantum Integrability and Entanglment Generators

    CERN Document Server

    Buric, Nikola

    2010-01-01

    Dynamical algebra notion of quantum degrees of freedom is utilized to study the relation between quantum dynamical integrability and generalized entanglement. It is argued that a quantum dynamical system generates generalized entanglement by internal dynamics if and only if it is quantum non-integrable. Several examples are used to illustrate the relation.

  10. Steam generator tube integrity flaw acceptance criteria

    Energy Technology Data Exchange (ETDEWEB)

    Cochet, B. [FRAMATOME, Paris la Defense (France)

    1997-02-01

    The author discusses the establishment of a flaw acceptance criteria with respect to flaws in steam generator tubing. The problem is complicated because different countries take different approaches to the problem. The objectives in general are grouped in three broad areas: to avoid the unscheduled shutdown of the reactor during normal operation; to avoid tube bursts; to avoid excessive leak rates in the event of an accidental overpressure event. For each degradation mechanism in the tubes it is necessary to know answers to an array of questions, including: how well does NDT testing perform against this problem; how rapidly does such degradation develop; how well is this degradation mechanism understood. Based on the above information it is then possible to come up with a policy to look at flaw acceptance. Part of this criteria is a schedule for the frequency of in-service inspection and also a policy for when to plug flawed tubes. The author goes into a broad discussion of each of these points in his paper.

  11. Patient-generated subjective global assessment

    NARCIS (Netherlands)

    Dr Harriët Jager-Wittenaar; Martine J. Sealy; Suzanne Kasenic; Elizabeth Isenring; Faith D. Ottery; Susan P. DeBolt

    2015-01-01

    Purpose: The Patient-Generated Subjective Global Assessment (PG-SGA), including the PG-SGA Short Form (SF, aka ‘abridged’), was originally developed in the mid 1990’s as a scored, patient self-report, paperbased instrument and has been widely validated. The PG-SGA (SF) has been used for screening,

  12. Patient-generated subjective global assessment

    NARCIS (Netherlands)

    Dr Harriët Jager-Wittenaar; Martine J. Sealy; Suzanne Kasenic; Elizabeth Isenring; Faith D. Ottery; Susan P. DeBolt

    2015-01-01

    Purpose: The Patient-Generated Subjective Global Assessment (PG-SGA), including the PG-SGA Short Form (SF, aka ‘abridged’), was originally developed in the mid 1990’s as a scored, patient self-report, paperbased instrument and has been widely validated. The PG-SGA (SF) has been used for screening, a

  13. Recent integrity program for WWER steam generator tubes

    Energy Technology Data Exchange (ETDEWEB)

    Wilam, M.; Papp, L.

    1994-12-31

    Considerable effort was given to NPP steam generator (SG) tubes integrity investigations during last years. These evaluations were focused on vertical SG tubing, i.e. on INCONEL tubes with geometry typical for this type of SG. The Steam Generator Tubes Integrity Program was conducted in VITKOVICE, R and D using WWER SG tubes. These tubes are made of 08Ch18N10T type stainless steel that corresponds to AISI 321 grade. The outer diameter of WWER tubes is 16 mm and the wall thickness is 1.5 mm.

  14. Two Integrator Loop Filters: Generation Using NAM Expansion and Review

    Directory of Open Access Journals (Sweden)

    Ahmed M. Soliman

    2010-01-01

    Full Text Available Systematic synthesis method to generate a family of two integrator loop filters based on nodal admittance matrix (NAM expansion is given. Eight equivalent circuits are obtained; six of them are new. Each of the generated circuits uses two grounded capacitors and employs two current conveyors (CCII or two inverting current conveyors (ICCII or a combination of both. The NAM expansion is also used to generate eight equivalent grounded passive elements two integrator loop filters using differential voltage current conveyor (DVCC; six of them are new. Changing the input port of excitation, two new families of eight unity gain lowpass filter circuits each using two CCII or ICCII or combination of both or two DVCC are obtained.

  15. Generation and transmission expansion planning for renewable energy integration

    Energy Technology Data Exchange (ETDEWEB)

    Bent, Russell W [Los Alamos National Laboratory; Berscheid, Alan [Los Alamos National Laboratory; Toole, G. Loren [Los Alamos National Laboratory

    2010-11-30

    In recent years the expansion planning problem has become increasingly complex. As expansion planning (sometimes called composite or integrated resource planning) is a non-linear and non-convex optimization problem, researchers have traditionally focused on approximate models of power flows to solve the problem. The problem has also been split into generation expansion planning (GEP) and transmission network expansion planning (TNEP) to improve computational tractability. Until recently these approximations have produced results that are straight-forward to combine and adapt to the more complex and complete problem. However, the power grid is evolving towards a state where the adaptations are no longer easy (e.g. large amounts of limited control, renewable generation, comparable generation and transmission construction costs) and necessitates new approaches. Recent work on deterministic Discrepancy Bounded Local Search (DBLS) has shown it to be quite effective in addressing the TNEP. In this paper, we propose a generalization of DBLS to handle simultaneous generation and transmission planning.

  16. Photonic-integrated circuit for continuous-wave THz generation.

    Science.gov (United States)

    Theurer, Michael; Göbel, Thorsten; Stanze, Dennis; Troppenz, Ute; Soares, Francisco; Grote, Norbert; Schell, Martin

    2013-10-01

    We demonstrate a photonic-integrated circuit for continuous-wave (cw) terahertz (THz) generation. By comprising two lasers and an optical phase modulator on a single chip, the full control of the THz signal is enabled via a unique bidirectional operation technique. Integrated heaters allow for continuous tuning of the THz frequency over 570 GHz. Applied to a coherent cw THz photomixing system operated at 1.5 μm optical wavelength, we reach a signal-to-noise ratio of 44 dB at 1.25 THz, which is identical to the performance of a standard system based on discrete components.

  17. Integrated Photonic Comb Generation: Applications in Coherent Communication and Sensing

    Science.gov (United States)

    Parker, John S.

    Integrated photonics combines many optical components including lasers, modulators, waveguides, and detectors in close proximity via homogeneous (monolithic) or heterogeneous (using multiple materials) integration. This improves stability for interferometers and lasers, reduces the occurrence of unwanted reflections, and it avoids coupling losses between different components as they are on the same chip. Thus, less power is needed to compensate for these added losses, and less heat needs to be removed due to these power savings. In addition, integration allows the many components that comprise a system to be fabricated together, thereby reducing the cost per system and allowing rapid scaling in production throughput. Integrated optical combs have many applications including: metrology, THz frequency generation, arbitrary waveform generation, optical clocks, photonic analog-to-digital converters, sensing (imaging), spectroscopy, and data communication. A comb is a set of optical sources evenly spaced in frequency. Several methods of comb generation including mode-locking and optical parametric oscillation produce phase-matched optical outputs with a fixed phase relationship between the frequency lines. When the absolute frequency of a single comb line is stabilized along with the frequency spacing between comb lines, absolute phase and frequency precision can be achieved over the entire comb bandwidth. This functionality provides tremendous benefits to many applications such as coherent communication and optical sensing. The goals for this work were achieving a broad comb bandwidth and noise reduction, i.e., frequency and phase stability. Integrated mode-locked lasers on the InGaAsP/InP material platform were chosen, as they could be monolithically integrated with the wide range of highly functional and versatile photonic integrated circuits (PICs) previously demonstrated on this platform at UCSB. Gain flattening filters were implemented to increase the comb

  18. Integration of Lignocellulosic Biomass into Renewable Energy Generation Concepts

    Directory of Open Access Journals (Sweden)

    KUSCH Sigrid

    2009-08-01

    Full Text Available In all European countries various lignocellulosic biomasses such as agricultural residues (straw, strawcontaining dung or fractions from municipal solid waste are available in large amounts, but currently hardly any of thispotential is being used for energy generation. This paper reviews the different options for including lignocellulosicbiomass into renewable energy generation schemes. Not all wastes are suitable to be treated by principally availabletechniques such as anaerobic digestion, ethanol production or thermal valorisation. The present paper gives an overviewof utilisation options for lignocellulosic biomass to either produce biofuels or to integrate such biomass into anaerobicdigestion. Biorefinery concepts are discussed as well.

  19. Fully integrated, fully automated generation of short tandem repeat profiles

    Science.gov (United States)

    2013-01-01

    Background The generation of short tandem repeat profiles, also referred to as ‘DNA typing,’ is not currently performed outside the laboratory because the process requires highly skilled technical operators and a controlled laboratory environment and infrastructure with several specialized instruments. The goal of this work was to develop a fully integrated system for the automated generation of short tandem repeat profiles from buccal swab samples, to improve forensic laboratory process flow as well as to enable short tandem repeat profile generation to be performed in police stations and in field-forward military, intelligence, and homeland security settings. Results An integrated system was developed consisting of an injection-molded microfluidic BioChipSet cassette, a ruggedized instrument, and expert system software. For each of five buccal swabs, the system purifies DNA using guanidinium-based lysis and silica binding, amplifies 15 short tandem repeat loci and the amelogenin locus, electrophoretically separates the resulting amplicons, and generates a profile. No operator processing of the samples is required, and the time from swab insertion to profile generation is 84 minutes. All required reagents are contained within the BioChipSet cassette; these consist of a lyophilized polymerase chain reaction mix and liquids for purification and electrophoretic separation. Profiles obtained from fully automated runs demonstrate that the integrated system generates concordant short tandem repeat profiles. The system exhibits single-base resolution from 100 to greater than 500 bases, with inter-run precision with a standard deviation of ±0.05 - 0.10 bases for most alleles. The reagents are stable for at least 6 months at 22°C, and the instrument has been designed and tested to Military Standard 810F for shock and vibration ruggedization. A nontechnical user can operate the system within or outside the laboratory. Conclusions The integrated system represents the

  20. Integrated biofuel facility, with carbon dioxide consumption and power generation

    Energy Technology Data Exchange (ETDEWEB)

    Powell, E.E.; Hill, G.A. [Saskatchewan Univ., Saskatoon, SK (Canada). Dept. of Chemical Engineering

    2009-07-01

    This presentation provided details of an economical design for a large-scale integrated biofuel facility for coupled production of bioethanol and biodiesel, with carbon dioxide capture and power generation. Several designs were suggested for both batch and continuous culture operations, taking into account all costs and revenues associated with the complete plant integration. The microalgae species Chlorella vulgaris was cultivated in a novel photobioreactor (PBR) in order to consume industrial carbon dioxide (CO{sub 2}). This photosynthetic culture can also act as a biocathode in a microbial fuel cell (MFC), which when coupled to a typical yeast anodic half cell, results in a complete biological MFC. The photosynthetic MFC produces electricity as well as valuable biomass and by-products. The use of this novel photosynthetic microalgae cathodic half cell in an integrated biofuel facility was discussed. A series of novel PBRs for continuous operation can be integrated into a large-scale bioethanol facility, where the PBRs serve as cathodic half cells and are coupled to the existing yeast fermentation tanks which act as anodic half cells. These coupled MFCs generate electricity for use within the biofuel facility. The microalgae growth provides oil for biodiesel production, in addition to the bioethanol from the yeast fermentation. The photosynthetic cultivation in the cathodic PBR also requires carbon dioxide, resulting in consumption of carbon dioxide from bioethanol production. The paper also discussed the effect of plant design on net present worth and internal rate of return. tabs., figs.

  1. IRREVERSIBILITY GENERATION IN SUGAR, ALCOHOL AND BIOGAS INTEGRATED PRODUCTIONS

    Directory of Open Access Journals (Sweden)

    Meilyn González Cortés

    2017-01-01

    Full Text Available In this work, the stages of losses and lower exergetic efficiency are determined when the sugar production process is integrated with others for the production of products such as biogas, torula yeast and electricity. The study is carried out in three scenarios of integrated processes for obtaining the indicated products. A sugar factory in which sugar and electricity are produced is considered as the base scenario and from this; a second scenario is inferred in which alcohol is produced from the molasses of the sugar process and biogas from the vinasse of the alcohol distillation process. Finally, a third scenario is exergetically evaluated in which sugar, electricity, biogas and alcohol are produced, but this last one from juices and molasses of the sugar process. For the exergetic analysis the integrated scheme was divided into 8 subsystems. From the analysis of results, the major subsystems that generate irreversibilities are: cogeneration (64.36-65.98%, juice extraction (8.85-9.85%, crystallization and cooking, (8.48 -9.02%, fermentation (4.12-4.94% and distillation (2.74-3.2%. Improvements are proposed to minimize irreversibilities, including the thermal integration of processes, technological modifications in the fermentation process and the introduction of more efficient equipment for the generation of electricity. The exergetic efficiency is between 78.95-81.10%, obtaining greater exergetic efficiency in the scheme of joint operation to produce sugar, alcohol and biogas.

  2. QIE: Performance Studies of the Next Generation Charge Integrator

    Energy Technology Data Exchange (ETDEWEB)

    Roy, T. [Florida Inst. Tech.; Yumiceva, F. [Florida Inst. Tech.; Hirschauer, J. [Fermilab; Freeman, J. [Fermilab; Hughes, E. [Rutgers U., Piscataway; Hare, D. [Fermilab; Dal Monte, L. [Fermilab; Whitbeck, A. [Fermilab; Zimmerman, T. [Fermilab

    2015-02-06

    The Phase 1 upgrade of the Hadron Calorimeter (HCAL) in the Compact Muon Solenoid (CMS) detector at the Large Hadron Collider (LHC) will include two new generations (named QIE10 and QIE11) of the radiation-tolerant flash ADC chip known as the Charge Integrator and Encoder or QIE. The QIE integrates charge from a photo sensor over a 25 ns time period and encodes the result in a non-linear digital output while having a good sensitivity in both the higher and the lower energy values. The charge integrator has the advantage of analyzing fast signals coming from the calorimeters as long as the timing and pulse information is available. The calorimeters send fast, negative polarity signals, which the QIE integrates in its non-inverting input amplifier. The input analog signal enters the QIE chip through two points: signal and reference. The chip integrates the difference between these two values. This helps in getting rid of the incoming noise, which is effectively cancelled out in the difference. Over a period of about six months between September, 2013 and April, 2014 about 320 QIE10 and about 20 QIE11 chips were tested in Fermilab using a single-chip test stand where every individual chip was tested for its characteristic features using a clam-shell. The results of those tests performed on the QIE10 and QIE11 are summarized in this document.

  3. [Clinical integration in the chronic patient].

    Science.gov (United States)

    Carretero-Alcántara, Luis; Comes-Górriz, Natividad; Borrás-López, Agustina; Rodríguez-Balo, Alberto; Seara-Aguilar, Germán

    2014-01-01

    Castilla-La Mancha Health Service is developing the integration of care levels due to the challenge of an aging population in the region. Aging is associated with chronic diseases and an increasing number of concomitant diseases. This poses a major care challenge care, with more fragile patients and new needs. This also requires a sustainable approach: the concurrence of several chronic diseases affects the cost of care, which is especially acute in times of severe economic crisis. One of the pillars of the strategy for dealing with chronic diseases in our region is care integration, in an effort to adapt the organization to the new needs. The Balanced Scorecard or Integrated Scorecard of the integration process was introduced as it has been designed. The integration of primary and hospital care at an organizational level has already been completed, and the development of integrated care processes has also been performed in order to achieve real integration at care level. To help finance this, a prospective capitation system is gradually being implemented, achieving a convergence of per capita costs in the different health areas integrated. Nurses has a key role in this process, their skills as educators and trainers in self-care, in the role of case managers of patients with particularly complex conditions, and the role of professional liaison to improve the transition between care areas and units.

  4. Experimental Investigation and Modeling of Integrated Tri-generation Systems

    Science.gov (United States)

    Cetinkaya, Eda

    Energy demand in the world is increasing with population growth and higher living standards. Today, the need for energy requires a focus on renewable sources without abandoning fossil fuels. Efficient use of energy is one of the most important tasks in modern energy systems to achieve. In addition to the energy need, growing environmental concerns are linked with energy is emerged. Multi-purpose energy generation allows a higher efficiency by generating more outputs with the same input in the same system. Tri-generation systems are expected to provide at least three commodities, such as heating, cooling, desalination, storable fuel production and some other useful outputs, in addition to power generation. In this study, an experimental investigation of gasification is presented and two integrated tri-generation systems are proposed. The first integrated tri-generation system (System 1) utilizes solar energy as input and the outputs are power, fresh water and hot water. It consists of four sub-systems, namely solar power tower system, desalination system, Rankine cycle and organic Rankine cycle (ORC). The second integrated tri-generation system (System 2) utilizes coal and biomass as input and the outputs are power, fuel and hot water. It consists of five sub-systems: gasification plant, Brayton cycle, Rankine cycle, Fischer-Tropsch synthesis plant and an organic Rankine cycle (ORC). Experimental investigation includes coal and biomass gasification, where the experimental results of synthesis gas compositions are utilized in the analysis of the second systems. To maximize efficiency, heat losses from the system should be minimized through a recovery system to make the heat a useful commodity for other systems, such as ORCs which can utilize the low-grade heat. In this respect, ORCs are first analyzed for three different configurations in terms of energy and exergy efficiencies altering working fluids to increase the power output. Among two types of coal and one type

  5. Perspectives of Integrative Cancer Genomics in Next Generation Sequencing Era

    Directory of Open Access Journals (Sweden)

    So Mee Kwon

    2012-06-01

    Full Text Available The explosive development of genomics technologies including microarrays and next generation sequencing (NGS has provided comprehensive maps of cancer genomes, including the expression of mRNAs and microRNAs, DNA copy numbers, sequence variations, and epigenetic changes. These genome-wide profiles of the genetic aberrations could reveal the candidates for diagnostic and/or prognostic biomarkers as well as mechanistic insights into tumor development and progression. Recent efforts to establish the huge cancer genome compendium and integrative omics analyses, so-called "integromics", have extended our understanding on the cancer genome, showing its daunting complexity and heterogeneity. However, the challenges of the structured integration, sharing, and interpretation of the big omics data still remain to be resolved. Here, we review several issues raised in cancer omics data analysis, including NGS, focusing particularly on the study design and analysis strategies. This might be helpful to understand the current trends and strategies of the rapidly evolving cancer genomics research.

  6. Integrative medicine and patient-centered care.

    Science.gov (United States)

    Maizes, Victoria; Rakel, David; Niemiec, Catherine

    2009-01-01

    Integrative medicine has emerged as a potential solution to the American healthcare crisis. It provides care that is patient centered, healing oriented, emphasizes the therapeutic relationship, and uses therapeutic approaches originating from conventional and alternative medicine. Initially driven by consumer demand, the attention integrative medicine places on understanding whole persons and assisting with lifestyle change is now being recognized as a strategy to address the epidemic of chronic diseases bankrupting our economy. This paper defines integrative medicine and its principles, describes the history of complementary and alternative medicine (CAM) in American healthcare, and discusses the current state and desired future of integrative medical practice. The importance of patient-centered care, patient empowerment, behavior change, continuity of care, outcomes research, and the challenges to successful integration are discussed. The authors suggest a model for an integrative healthcare system grounded in team-based care. A primary health partner who knows the patient well, is able to addresses mind, body, and spiritual needs, and coordinates care with the help of a team of practitioners is at the centerpiece. Collectively, the team can meet all the health needs of the particular patient and forms the patient-centered medical home. The paper culminates with 10 recommendations directed to key actors to facilitate the systemic changes needed for a functional healthcare delivery system. Recommendations include creating financial incentives aligned with health promotion and prevention. Insurers are requested to consider the total costs of care, the potential cost effectiveness of lifestyle approaches and CAM modalities, and the value of longer office visits to develop a therapeutic relationship and stimulate behavioral change. Outcomes research to track the effectiveness of integrative models must be funded, as well as feedback and dissemination strategies

  7. Integrated Navigation System for the Second Generation Reusable Launch Vehicle

    Science.gov (United States)

    2002-01-01

    An array of components in a laboratory at NASA's Marshall Space Flight Center (MSFC) is being tested by the Flight Mechanics Office to develop an integrated navigation system for the second generation reusable launch vehicle. The laboratory is testing Global Positioning System (GPS) components, a satellite-based location and navigation system, and Inertial Navigation System (INS) components, sensors on a vehicle that determine angular velocity and linear acceleration at various points. The GPS and INS components work together to provide a space vehicle with guidance and navigation, like the push of the OnStar button in your car assists you with directions to a specific address. The integration will enable the vehicle operating system to track where the vehicle is in space and define its trajectory. The use of INS components for navigation is not new to space technology. The Space Shuttle currently uses them. However, the Space Launch Initiative is expanding the technology to integrate GPS and INS components to allow the vehicle to better define its position and more accurately determine vehicle acceleration and velocity. This advanced technology will lower operational costs and enhance the safety of reusable launch vehicles by providing a more comprehensive navigation system with greater capabilities. In this photograph, Dr. Jason Chuang of MSFC inspects an INS component in the laboratory.

  8. Integrated photoelectrochemical energy storage: solar hydrogen generation and supercapacitor.

    Science.gov (United States)

    Xia, Xinhui; Luo, Jingshan; Zeng, Zhiyuan; Guan, Cao; Zhang, Yongqi; Tu, Jiangping; Zhang, Hua; Fan, Hong Jin

    2012-01-01

    Current solar energy harvest and storage are so far realized by independent technologies (such as solar cell and batteries), by which only a fraction of solar energy is utilized. It is highly desirable to improve the utilization efficiency of solar energy. Here, we construct an integrated photoelectrochemical device with simultaneous supercapacitor and hydrogen evolution functions based on TiO(2)/transition metal hydroxides/oxides core/shell nanorod arrays. The feasibility of solar-driven pseudocapacitance is clearly demonstrated, and the charge/discharge is indicated by reversible color changes (photochromism). In such an integrated device, the photogenerated electrons are utilized for H(2) generation and holes for pseudocapacitive charging, so that both the reductive and oxidative energies are captured and converted. Specific capacitances of 482 F g(-1) at 0.5 A g(-1) and 287 F g(-1) at 1 A g(-1) are obtained with TiO(2)/Ni(OH)(2) nanorod arrays. This study provides a new research strategy for integrated pseudocapacitor and solar energy application.

  9. Steam Generator tube integrity -- US Nuclear Regulatory Commission perspective

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, E.L.; Sullivan, E.J.

    1997-02-01

    In the US, the current regulatory framework was developed in the 1970s when general wall thinning was the dominant degradation mechanism; and, as a result of changes in the forms of degradation being observed and improvements in inspection and tube repair technology, the regulatory framework needs to be updated. Operating experience indicates that the current U.S. requirements should be more stringent in some areas, while in other areas they are overly conservative. To date, this situation has been dealt with on a plant-specific basis in the US. However, the NRC staff is now developing a proposed steam generator rule as a generic framework for ensuring that the steam generator tubes are capable of performing their intended safety functions. This paper discusses the current U.S. regulatory framework for assuring steam generator (SG) tube integrity, the need to update this regulatory framework, the objectives of the new proposed rule, the US Nuclear Regulatory Commission (NRC) regulatory guide (RG) that will accompany the rule, how risk considerations affect the development of the new rule, and some outstanding issues relating to the rule that the NRC is still dealing with.

  10. An integrated MEMS infrastructure for fuel processing: hydrogen generation and separation for portable power generation

    Science.gov (United States)

    Varady, M. J.; McLeod, L.; Meacham, J. M.; Degertekin, F. L.; Fedorov, A. G.

    2007-09-01

    Portable fuel cells are an enabling technology for high efficiency and ultra-high density distributed power generation, which is essential for many terrestrial and aerospace applications. A key element of fuel cell power sources is the fuel processor, which should have the capability to efficiently reform liquid fuels and produce high purity hydrogen that is consumed by the fuel cells. To this end, we are reporting on the development of two novel MEMS hydrogen generators with improved functionality achieved through an innovative process organization and system integration approach that exploits the advantages of transport and catalysis on the micro/nano scale. One fuel processor design utilizes transient, reverse-flow operation of an autothermal MEMS microreactor with an intimately integrated, micromachined ultrasonic fuel atomizer and a Pd/Ag membrane for in situ hydrogen separation from the product stream. The other design features a simpler, more compact planar structure with the atomized fuel ejected directly onto the catalyst layer, which is coupled to an integrated hydrogen selective membrane.

  11. Integrating Renewable Generation into Grid Operations: Four International Experiences

    Energy Technology Data Exchange (ETDEWEB)

    Weimar, Mark R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Mylrea, Michael E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Levin, Todd [Argonne National Lab. (ANL), Argonne, IL (United States); Botterud, Audun [Argonne National Lab. (ANL), Argonne, IL (United States); O' Shaughnessy, Eric [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bird, Lori [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-04-22

    synchronous generation. Interconnections to other regions provides added opportunities for balancing that would not be available otherwise, and at this point, has allowed for integration of renewables.

  12. SCHOOL INTEGRATION FOR PATIENTS WITH AMBLYOPIA.

    Science.gov (United States)

    Bogdanici, Stefan Tudor; Roman, Alexandra; Bogdanici, Camelia

    2015-01-01

    to identify the difficulties of social integration in patients with amblyopia, as well as the correlation between school results and the level of amblyopia. An observational prospective study was performed in an interval of 2 years (2012-2014) for 43 amblyopic patients (24 females and 19 males), with age between 7 and 24 years. Patients were treated in "Sf. Spiridon" Hospital and Stereopsis Ophthalmological Clinic, Iasi. The patient or the assistant (parent, social assistant or grandparent) have filled in a questionnaire with 15 topics about school results and integration. Clinical parameters were registered for each patient: corrected visual acuity, type of optical correction, type of amblyopia, type of school attended, position in the desk, school results, behavior attitude, family involvement. All data was statistically analyzed. The cases were classified in three types of amblyopia: strabic amblyopia (11,63%), refractive amblyopia (67,44%) and deprivation amblyopia (20,93%). Depending on the value of visual acuity, one eye was with prosthetic, 11, 62% had moderate amblyopia and 32, 56% were cases with severe amblyopia. The majority of children were enrolled in normal schools (81,39%), 11,63% in special schools for children with low-vision and 2 patients were students (4,65%). Position of children in classroom was in 81,4% in first or second desk. Only 27,0% had very good results in school. Students had a social integration for study in faculties. A child with severe amblyopia has good or very good scholar results if the involvement of family and society is increased. There is no correlation between the position in the desk and the level of preparation. It is necessary an individualized educational attention for patients with amblyopia.

  13. Developing integrated patient pathways using hybrid simulation

    Science.gov (United States)

    Zulkepli, Jafri; Eldabi, Tillal

    2016-10-01

    Integrated patient pathways includes several departments, i.e. healthcare which includes emergency care and inpatient ward; intermediate care which patient(s) will stay for a maximum of two weeks and at the same time be assessed by assessment team to find the most suitable care; and social care. The reason behind introducing the intermediate care in western countries was to reduce the rate of patients that stays in the hospital especially for elderly patients. This type of care setting has been considered to be set up in some other countries including Malaysia. Therefore, to assess the advantages of introducing this type of integrated healthcare setting, we suggest develop the model using simulation technique. We argue that single simulation technique is not viable enough to represent this type of patient pathways. Therefore, we suggest develop this model using hybrid techniques, i.e. System Dynamics (SD) and Discrete Event Simulation (DES). Based on hybrid model result, we argued that the result is viable to be as references for decision making process.

  14. An Innovative Reconfigurable Integrated Converter Topology Suitable for Distributed Generation

    Directory of Open Access Journals (Sweden)

    Renato Rizzo

    2012-09-01

    Full Text Available The electricity market and environmental concerns, with wide utilization of renewable sources, have improved the diffusion of distributed generation units changing the operations of distribution grids from passive networks to microgrids. A microgrid includes a cluster of electrical loads, energy storage devices and microsources, which provide both power and heat to their local area. A microgrid has usually one connection point to the utility grid through power electronic converters placed at customers’ sites. This paper analyses a Reconfigurable Integrated Converter (RIC used for a domestic microgrid with inputs from the AC mains and photovoltaic arrays, and two DC outputs at different voltage levels. A RIC as a dual-boost DC-DC converter is proposed, modelled and analysed in the paper. The advantages of such a topology in comparison with traditional boost converters are outlined. Reported simulations results give evidence on the controllability of this converter and the capability of achieving the desired voltage outputs with reduced ripple.

  15. INTEGRATED POWER GENERATION SYSTEMS FOR COAL MINE WASTE METHANE UTILIZATION

    Energy Technology Data Exchange (ETDEWEB)

    Peet M. Soot; Dale R. Jesse; Michael E. Smith

    2005-08-01

    An integrated system to utilize the waste coal mine methane (CMM) at the Federal No. 2 Coal Mine in West Virginia was designed and built. The system includes power generation, using internal combustion engines, along with gas processing equipment to upgrade sub-quality waste methane to pipeline quality standards. The power generation has a nominal capacity of 1,200 kw and the gas processing system can treat about 1 million cubic feet per day (1 MMCFD) of gas. The gas processing is based on the Northwest Fuel Development, Inc. (NW Fuel) proprietary continuous pressure swing adsorption (CPSA) process that can remove nitrogen from CMM streams. The two major components of the integrated system are synergistic. The byproduct gas stream from the gas processing equipment can be used as fuel for the power generating equipment. In return, the power generating equipment provides the nominal power requirements of the gas processing equipment. This Phase III effort followed Phase I, which was comprised of a feasibility study for the project, and Phase II, where the final design for the commercial-scale demonstration was completed. The fact that NW Fuel is desirous of continuing to operate the equipment on a commercial basis provides the validation for having advanced the project through all of these phases. The limitation experienced by the project during Phase III was that the CMM available to operate the CPSA system on a commercial basis was not of sufficiently high quality. NW Fuel's CPSA process is limited in its applicability, requiring a relatively high quality of gas as the feed to the process. The CPSA process was demonstrated during Phase III for a limited time, during which the processing capabilities met the expected results, but the process was never capable of providing pipeline quality gas from the available low quality CMM. The NW Fuel CPSA process is a low-cost ''polishing unit'' capable of removing a few percent nitrogen. It was never

  16. Integration of Thermoelectric Generator and Wireless Sensor Node Simulators

    Energy Technology Data Exchange (ETDEWEB)

    Agarwal, Vivek [Idaho National Lab. (INL), Idaho Falls, ID (United States); Zhang, Yanliang [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-09-01

    This report focuses on integrating TEG and WSN simulators with DC-DC converter as an interface. Here DC stands for direct current. DC-DC converter is essential to balance a wide range of analog, digital, and radio loads acting on the energy source. Also, the voltage level generated by TEGs under varying temperature conditions could be low, irregular, and insufficient to operate WSN, therefore DC-DC is required to boost up the voltage to a desired level. Most of the main problems of DC-DC converters used in TEG system are related to impedance matching between the internal resistance of TEG and the input resistance of DC-DC converter. This report would address the issue associated with dynamic impedance matching under varying temperature conditions in the effort to integrate TEG and WSN. In this effort, dynamic impedance matching algorithms like perturb and observe (P&O) and extremum seeking control (ESC) algorithms will de implemented and compared to achieve maximum peak power tracking (MPPT). In addition, the report will summarize the experimental study performed at BSU on profiling behavior of WSN prototype.

  17. Integration of distributed generation in the power system

    CERN Document Server

    Bollen, Math H J

    2011-01-01

    "The integration of new sources of energy like wind power, solar-power, small-scale generation, or combined heat and power in the power grid is something that impacts a lot of stakeholders: network companies (both distribution and transmission), the owners and operators of the DG units, other end-users of the power grid (including normal consumers like you and me) and not in the least policy makers and regulators. There is a lot of misunderstanding about the impact of DG on the power grid, with one side (including mainly some but certainly not all, network companies) claiming that the lights will go out soon, whereas the other side (including some DG operators and large parks of the general public) claiming that there is nothing to worry about and that it's all a conspiracy of the large production companies that want to protect their own interests and keep the electricity price high. The authors are of the strong opinion that this is NOT the way one should approach such an important subject as the integration...

  18. Next-generation digital camera integration and software development issues

    Science.gov (United States)

    Venkataraman, Shyam; Peters, Ken; Hecht, Richard

    1998-04-01

    This paper investigates the complexities associated with the development of next generation digital cameras due to requirements in connectivity and interoperability. Each successive generation of digital camera improves drastically in cost, performance, resolution, image quality and interoperability features. This is being accomplished by advancements in a number of areas: research, silicon, standards, etc. As the capabilities of these cameras increase, so do the requirements for both hardware and software. Today, there are two single chip camera solutions in the market including the Motorola MPC 823 and LSI DCAM- 101. Real time constraints for a digital camera may be defined by the maximum time allowable between capture of images. Constraints in the design of an embedded digital camera include processor architecture, memory, processing speed and the real-time operating systems. This paper will present the LSI DCAM-101, a single-chip digital camera solution. It will present an overview of the architecture and the challenges in hardware and software for supporting streaming video in such a complex device. Issues presented include the development of the data flow software architecture, testing and integration on this complex silicon device. The strategy for optimizing performance on the architecture will also be presented.

  19. Integrated visualization of problemcentric urologic patient records.

    Science.gov (United States)

    Bui, Aleex A T; Taira, Ricky K; Churchill, Bernard; Kangarloo, Hooshang

    2002-12-01

    The collision of computer-based technologies and the medical environment is resulting in an increasingly electronic multimedia patient record, consisting of not only the traditional types of data (e.g., clinic notes and laboratory reports), but also digital images (e.g., computed tomography and magnetic resonance imaging) and other visual representations of patient data (e.g., pulmonary function graphs and urodynamic charts). Given the increasing amount of data made available to physicians, it is not only critical that the totality of a patient's medical record be accessible to a clinician, but that the diverse data be integrated and presented in a manner conducive to patient management: key information should be easily discovered. This paper describes a problemcentric time-based visualization of urologic conditions, whereby a patient's medical history is automatically organized around a medical problem and presented as a graphic chronology. Urology-related data in the patient medical record is organized in accord with an expert constructed knowledge-base, and plotted on a timeline using iconic representations. The user interface permits the physician to quickly view multimedia data and to visualize relationships between events in the patient's history.

  20. Next Generation Integrated Environment for Collaborative Work Across Internets

    Energy Technology Data Exchange (ETDEWEB)

    Harvey B. Newman

    2009-02-24

    We are now well-advanced in our development, prototyping and deployment of a high performance next generation Integrated Environment for Collaborative Work. The system, aimed at using the capability of ESnet and Internet2 for rapid data exchange, is based on the Virtual Room Videoconferencing System (VRVS) developed by Caltech. The VRVS system has been chosen by the Internet2 Digital Video (I2-DV) Initiative as a preferred foundation for the development of advanced video, audio and multimedia collaborative applications by the Internet2 community. Today, the system supports high-end, broadcast-quality interactivity, while enabling a wide variety of clients (Mbone, H.323) to participate in the same conference by running different standard protocols in different contexts with different bandwidth connection limitations, has a fully Web-integrated user interface, developers and administrative APIs, a widely scalable video network topology based on both multicast domains and unicast tunnels, and demonstrated multiplatform support. This has led to its rapidly expanding production use for national and international scientific collaborations in more than 60 countries. We are also in the process of creating a 'testbed video network' and developing the necessary middleware to support a set of new and essential requirements for rapid data exchange, and a high level of interactivity in large-scale scientific collaborations. These include a set of tunable, scalable differentiated network services adapted to each of the data streams associated with a large number of collaborative sessions, policy-based and network state-based resource scheduling, authentication, and optional encryption to maintain confidentiality of inter-personal communications. High performance testbed video networks will be established in ESnet and Internet2 to test and tune the implementation, using a few target application-sets.

  1. Visualization of the Eastern Renewable Generation Integration Study: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Gruchalla, Kenny; Novacheck, Joshua; Bloom, Aaron

    2016-12-01

    The Eastern Renewable Generation Integration Study (ERGIS), explores the operational impacts of the wide spread adoption of wind and solar photovoltaics (PV) resources in the U.S. Eastern Interconnection and Quebec Interconnection (collectively, EI). In order to understand some of the economic and reliability challenges of managing hundreds of gigawatts of wind and PV generation, we developed state of the art tools, data, and models for simulating power system operations using hourly unit commitment and 5-minute economic dispatch over an entire year. Using NREL's high-performance computing capabilities and new methodologies to model operations, we found that the EI, as simulated with evolutionary change in 2026, could balance the variability and uncertainty of wind and PV at a 5-minute level under a variety of conditions. A large-scale display and a combination of multiple coordinated views and small multiples were used to visually analyze the four large highly multivariate scenarios with high spatial and temporal resolutions. state of the art tools, data, and models for simulating power system operations using hourly unit commitment and 5-minute economic dispatch over an entire year. Using NRELs high-performance computing capabilities and new methodologies to model operations, we found that the EI, as simulated with evolutionary change in 2026, could balance the variability and uncertainty of wind and PV at a 5-minute level under a variety of conditions. A large-scale display and a combination of multiple coordinated views and small multiples were used to visually analyze the four large highly multivariate scenarios with high spatial and temporal resolutions.

  2. Generation of human induced pluripotent stem cells using genome integrating or non-integrating methods.

    Science.gov (United States)

    Šimara, P; Tesařová, L; Padourová, S; Koutná, I

    2014-01-01

    Preclinical studies have demonstrated the promising potential of human induced pluripotent stem cells (hiPSCs) for clinical application. To fulfil this goal, efficient and safe methods to generate them must be established. Various reprogramming techniques were presented during seven years of hiPSCs research. Genome non-integrating and completely xeno-free protocols from the first biopsy to stable hiPSC clones are highly preferable in terms of future clinical application. In this short communication, we summarize the reprogramming experiments performed in our laboratories. We successfully generated hiPSCs using STEMCCA lentivirus, Sendai virus or episomal vectors. Human neonatal fibroblasts and CD34(+) blood progenitors were used as cell sources and were maintained either on mouse embryonic feeder cells or in feeder-free conditions. The reprogramming efficiency was comparable for all three methods and both cell types, while the best results were obtained in feeder-free conditions.

  3. Clinical evaluation of emboli removal by integrated versus non-integrated arterial filters in new generation oxygenators.

    Science.gov (United States)

    Jabur, Ghazwan Ns; Sidhu, Karishma; Willcox, Timothy W; Mitchell, Simon J

    2016-07-01

    To compare the emboli filtration efficiency of five integrated or non-integrated oxygenator-filter combinations in cardiopulmonary bypass circuits. Fifty-one adult patients underwent surgery using a circuit with an integrated filtration oxygenator or non-integrated oxygenator with a separate 20 µm arterial line filter (Sorin Dideco Avant D903 + Pall AL20 (n=12), Sorin Inspire 6 M + Pall AL20 (n=10), Sorin Inspire 6M F (n=9), Terumo FX25 (n=10), Medtronic Fusion (n=10)). The Emboli Detection and Classification quantifier was used to count emboli upstream and downstream of the primary filter throughout cardiopulmonary bypass. The primary outcome measure was to compare the devices in respect of the median proportion of emboli removed. One device (Sorin Inspire 6 M + Pall AL20) exhibited a significantly greater median percentage reduction (96.77%, IQR=95.48 - 98.45) in total emboli counts compared to all other devices tested (p=0.0062 - 0.0002). In comparisons between the other units, they all removed a greater percentage of emboli than one device (Medtronic Fusion), but there were no other significant differences. The new generation Sorin Inspire 6 M, with a stand-alone 20 µm arterial filter, appeared most efficient at removing incoming emboli from the circuit. No firm conclusions can be drawn about the relative efficacy of emboli removal by units categorised by class (integrated vs non-integrated); however, the stand-alone 20 µm arterial filter presently sets a contemporary standard against which other configurations of equipment can be judged. © The Author(s) 2015.

  4. Structural and leakage integrity assessment of WWER steam generator tubes

    Energy Technology Data Exchange (ETDEWEB)

    Splichal, K.; Otruba, J. [Nuclear Research Inst., Rez (Switzerland)

    1997-12-31

    The integrity of heat exchange tubes may influence the life-time of WWER steam generators and appears to be an important criterion for the evaluation of their safety and operational reliability. The basic requirement is to assure a very low probability of radioactive water leakage, preventing unstable crack growth and sudden tube rupture. These requirements led to development of permissible limits for primary to secondary leak evolution and heat exchange tubes plugging based on eddy current test inspection. The stress corrosion cracking and pitting are the main corrosion damage of WWER heat exchange tubes and are initiated from the outer surface. They are influenced by water chemistry, temperature and tube wall stress level. They take place under crevice corrosion condition and are indicated especially (1) under the tube support plates, where up to 90-95 % of defects detected by the ECT method occur, and (2) on free spans under tube deposit layers. Both the initiation and crack growth cause thinning of the tube wall and lead to part thickness cracks and through-wall cracks, oriented above all in the axial direction. 10 refs.

  5. Integral Radiators for Next Generation Thermal Control Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Integral radiators integrate the primary structural system and the thermal rejection system into a dual function subsystem allowing for reduced weight. The design of...

  6. Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids.

    Science.gov (United States)

    Meraviglia, Viviana; Zanon, Alessandra; Lavdas, Alexandros A; Schwienbacher, Christine; Silipigni, Rosamaria; Di Segni, Marina; Chen, Huei-Sheng Vincent; Pramstaller, Peter P; Hicks, Andrew A; Rossini, Alessandra

    2015-06-05

    Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by forcing the expression of four transcription factors (Oct-4, Sox-2, Klf-4, and c-Myc), typically expressed by human embryonic stem cells (hESCs). Due to their similarity with hESCs, iPSCs have become an important tool for potential patient-specific regenerative medicine, avoiding ethical issues associated with hESCs. In order to obtain cells suitable for clinical application, transgene-free iPSCs need to be generated to avoid transgene reactivation, altered gene expression and misguided differentiation. Moreover, a highly efficient and inexpensive reprogramming method is necessary to derive sufficient iPSCs for therapeutic purposes. Given this need, an efficient non-integrating episomal plasmid approach is the preferable choice for iPSC derivation. Currently the most common cell type used for reprogramming purposes are fibroblasts, the isolation of which requires tissue biopsy, an invasive surgical procedure for the patient. Therefore, human peripheral blood represents the most accessible and least invasive tissue for iPSC generation. In this study, a cost-effective and viral-free protocol using non-integrating episomal plasmids is reported for the generation of iPSCs from human peripheral blood mononuclear cells (PBMNCs) obtained from frozen buffy coats after whole blood centrifugation and without density gradient separation.

  7. Generating personalized advice for schizophrenia patients

    NARCIS (Netherlands)

    Emerencia, A.; van der Krieke, Lian; Sytema, S.; Petkov, N.; Aiello, M.

    The results of routine patient assessments in psychiatric healthcare in the Northern Netherlands are primarily used to support clinicians. We developed Wegweis, a web-based advice platform, to make this data accessible and understandable for patients. Objective: We show that a fully automated

  8. Specification and Generation of Adapters for System Integration

    NARCIS (Netherlands)

    Mooij, A.J.; Voorhoeve, M.

    2013-01-01

    Large systems-of-systems are developed by integrating several smaller systems that have been developed independently. System integration often requires adaptation mechanisms for bridging any technical incompatibilities between the systems. In order to develop adapters in a faster way, we study ways

  9. Integration of Renewable Generation in Power System Defence Plans

    OpenAIRE

    Das, Kaushik; Sørensen, Poul Ejnar; Anca Daniela HANSEN; Abildgaard, Hans

    2016-01-01

    Increasing levels of penetration of wind power and other renewable generations in European power systems pose challenges to power system security. The power system operators are continuously challenged especially when generations from renewables are high thereby reducing online capacity of conventional controllable generations to minimum. In such operation hours, the system is typically more vulnerable to disturbances in general and major disturbances in particular. This was the case in the m...

  10. Realization of Quadrature Signal Generator Using Accurate Magnitude Integrator

    DEFF Research Database (Denmark)

    Xin, Zhen; Yoon, Changwoo; Zhao, Rende

    2016-01-01

    -signal parameters, espically when a fast resonse is required for usages such as grid synchronization. As a result, the parameters design of the SOGI-QSG becomes complicated. Theoretical analysis shows that it is caused by the inaccurate magnitude-integration characteristic of the SOGI-QSG. To solve this problem......, an Accurate-Magnitude-Integrator based QSG (AMI-QSG) is proposed. The AMI has an accurate magnitude-integration characteristic for the sinusoidal signal, which makes the AMI-QSG possess an accurate First-Order-System (FOS) characteristic in terms of magnitude than the SOGI-QSG. The parameter design process...

  11. Generation of Integration-free Human Induced Pluripotent Stem Cells Using Hair-derived Keratinocytes.

    Science.gov (United States)

    Hung, Sandy S C; Pébay, Alice; Wong, Raymond C B

    2015-08-20

    Recent advances in reprogramming allow us to turn somatic cells into human induced pluripotent stem cells (hiPSCs). Disease modeling using patient-specific hiPSCs allows the study of the underlying mechanism for pathogenesis, also providing a platform for the development of in vitro drug screening and gene therapy to improve treatment options. The promising potential of hiPSCs for regenerative medicine is also evident from the increasing number of publications (>7000) on iPSCs in recent years. Various cell types from distinct lineages have been successfully used for hiPSC generation, including skin fibroblasts, hematopoietic cells and epidermal keratinocytes. While skin biopsies and blood collection are routinely performed in many labs as a source of somatic cells for the generation of hiPSCs, the collection and subsequent derivation of hair keratinocytes are less commonly used. Hair-derived keratinocytes represent a non-invasive approach to obtain cell samples from patients. Here we outline a simple non-invasive method for the derivation of keratinocytes from plucked hair. We also provide instructions for maintenance of keratinocytes and subsequent reprogramming to generate integration-free hiPSC using episomal vectors.

  12. Distributed Storage Inverter and Legacy Generator Integration Plus Renewables Solution for Microgrids

    Science.gov (United States)

    2015-07-01

    with small-scale power storage can maintain power quality in islanded mode with minimal use of the generators during non-optimal (e.g. cloud covered...inverter ( advantage of short term storage ) and enables microgrid upgrade of legacy generator assets (integration of inverter and generator controllers...microgrid stability, and can further be integrated with the distributed power storage to address intermittent loss of PV energy as when a cloud passes

  13. Generating Editors for Embedded Languages: Integrating SGLR into IMP

    NARCIS (Netherlands)

    Kats, L.; Kalleberg, K.T.; Visser, E.

    2008-01-01

    Preprint of paper published in: LDTA 2008: 8th Workshop on Language Descriptions, Tools and Applications, 5 April 2008 Integrated Development Environments (IDEs) increase productivity by providing a rich user interface and rapid feedback for a specific language. Creating an editor for a specific la

  14. TECHNOECONOMIC APPRAISAL OF INTEGRATED GASIFICATION COMBINED-CYCLE POWER GENERATION

    Science.gov (United States)

    The report is a technoeconomic appraisal of the integrated (coal) gasification combined-cycle (IGCC) system. lthough not yet a proven commercial technology, IGCC is a future competitive technology to current pulverized-coal boilers equipped with SO2 and NOx controls, because of i...

  15. TECHNOECONOMIC APPRAISAL OF INTEGRATED GASIFICATION COMBINED-CYCLE POWER GENERATION

    Science.gov (United States)

    The report is a technoeconomic appraisal of the integrated (coal) gasification combined-cycle (IGCC) system. lthough not yet a proven commercial technology, IGCC is a future competitive technology to current pulverized-coal boilers equipped with SO2 and NOx controls, because of i...

  16. From Modules to a Generator: An Integrated Heat Exchanger Concept for Car Applications of a Thermoelectric Generator

    Science.gov (United States)

    Bosch, Henry

    2016-03-01

    A heat exchanger concept for a thermoelectric generator with integrated planar modules for passenger car applications is introduced. The module housings, made of deep drawn stainless steel sheet metal, are brazed onto the exhaust gas channel to achieve an optimal heat transfer on the hot side of the modules. The cooling side consists of winding fluid channels, which are mounted directly onto the cold side of the modules. Only a thin foil separates the cooling media from the modules for an almost direct heat contact on the cooling side. Thermoelectric generators with up to 20 modules made of PbTe and Bi2Te3, respectively, are manufactured and tested on a hot gas generator to investigate electrical power output and performance of the thermoelectric generator. The proof of concept of the light weight heat exchanger design made of sheet metal with integrated modules is positively accomplished.

  17. Evaluation of steam generator WWER 440 tube integrity criteria

    Energy Technology Data Exchange (ETDEWEB)

    Splichal, K.; Otruba, J.; Burda, J. [Nuclear Research Institute Rez plc. (Czechoslovakia)

    1997-02-01

    The main corrosion damage in WWER steam generators under operating conditions has been observed on the outer surface of these tubes. An essential operational requirement is to assure a low probability of radioactive primary water leakage, unstable defect development and rupture of tubes. In the case of WWER 440 steam generators the above requirements led to the development of permissible limits for data evaluation of the primary-to-secondary leak measurements and determination of acceptable values for plugging of heat exchange tubes based on eddy current test (ECT) inspections.

  18. Steam generator tubes integrity: In-service-inspection

    Energy Technology Data Exchange (ETDEWEB)

    Comby, R.J. [EDF/GDL, Saint Denis (France)

    1997-02-01

    The author`s approach to tube integrity is in terms of looking for flaws in tubes. The basis for this approach is that no simple rules can be fixed to adopt a universal inspection methodology because of various concepts related to experience, leak acceptance, leak before break approach, etc. Flaw specific management is probably the most reliable approach as a compromise between safety, availability and economic issues. In that case, NDE capabilities have to be in accordance with information required by structural integrity demonstration. The author discusses the types of probes which can be used to search for flaws in addition to the types of flaws which are being sought, with examples of specific analysis experiences. The author also discusses the issue of a reporting level as it relates to avoiding false calls, classifying faults, and allowing for automation in analysis.

  19. The Vulnerability Framework Integrates Various Models of Generating Surplus Revenue

    Science.gov (United States)

    Maniaci, Vincent

    2004-01-01

    Budgets operationalize the strategic planning process, and institutions must have surplus revenue to be able to cope with future operations. There are three approaches to generate surplus revenue: increased revenue, decreased cost, and reallocation of resources. Extending their earlier work, where they established strategic benchmarks for annual…

  20. Steam generator asset management: integrating technology and asset management

    Energy Technology Data Exchange (ETDEWEB)

    Shoemaker, P.; Cislo, D. [AREVA NP Inc., Lynchburg, Virginia (United States)]. E-mail: paul.shoemaker@areva.com

    2006-07-01

    Asset Management is an established but often misunderstood discipline that is gaining momentum within the nuclear generation industry. The global impetus behind the movement toward asset management is sustainability. The discipline of asset management is based upon three fundamental aspects; key performance indicators (KPI), activity-based cost accounting, and cost benefits/risk analysis. The technology associated with these three aspects is fairly well-developed, in all but the most critical area; cost benefits/risk analysis. There are software programs that calculate, trend, and display key-performance indicators to ensure high-level visibility. Activity-based costing is a little more difficult; requiring a consensus on the definition of what comprises an activity and then adjusting cost accounting systems to track. In the United States, the Nuclear Energy Institute's Standard Nuclear Process Model (SNPM) serves as the basis for activity-based costing. As a result, the software industry has quickly adapted to develop tracking systems that include the SNPM structure. Both the KPI's and the activity-based cost accounting feed the cost benefits/risk analysis to allow for continuous improvement and task optimization; the goal of asset management. In the case where the benefits and risks are clearly understood and defined, there has been much progress in applying technology for continuous improvement. Within the nuclear generation industry, more specialized and unique software systems have been developed for active components, such as pumps and motors. Active components lend themselves well to the application of asset management techniques because failure rates can be established, which serves as the basis to quantify risk in the cost-benefits/risk analysis. A key issue with respect to asset management technologies is only now being understood and addressed, that is how to manage passive components. Passive components, such as nuclear steam generators

  1. Integrated Nanophotonic Silicon Devices for Next Generation Computing Chips

    Science.gov (United States)

    Djordjevic, Stevan

    Development of the computing platform of the future depends largely on high bandwidth interconnects at intra-die level. Silicon photonics, as an innately CMOS compatible technology, is a promising candidate for delivering terabit per second bandwidths through the use of wavelength division multiplex (WDM) signaling. Silicon photonic interconnects offer unmatched bandwidth, density, energy efficiency, latency and reach, compared with the electrical interconnects. WDM silicon photonic links are viewed today as a promising solution for resolving the inter/intra-chip communication bottlenecks for high performance computing systems. Towards its maturity, silicon photonic technology has to resolve the issues of waveguide propagation loss, density of device integration, thermal stability of resonant devices, heterogeneous integration of various materials and many other problems. This dissertation describes the development of integrated photonic technology on silicon and silicon nitride platforms in the increased order of device complexity, from the fabrication process of low loss waveguides and efficient off-chip coupling devices, to the die-size reconfigurable lattice filters for optical signal processing. Particular emphasis of the dissertation is on the demonstration of CMOS-compatible, athermal silicon ring modulators that potentially hold the key to solving the thermal problem of silicon photonic devices. The development of high quality amorphous titanium dioxide films with negative thermo-optic coefficient enabled the fabrication of gigahertz-bandwidth silicon ring modulators that can be made insensitive to ambient temperature changes.

  2. Caring for Patients of the Millennial Generation: Considerations for Nurses.

    Science.gov (United States)

    Johanson, Linda S

    2017-07-01

    Much has been written about teaching students of the Millennial Generation (those born between the years 1980 and 2000) and about intergenerational dynamics in the healthcare workforce. However, little can be found in the literature regarding generation-specific nursing care of Millennial patients. This article presents six categories of considerations for nurses caring for patients of the Millennial Generation based on the characteristics, attitudes, and values that have influenced them as well as the healthcare issues confronting this group of young adults. © 2016 Wiley Periodicals, Inc.

  3. An integrated approach to microalgae biomass generation and processing

    OpenAIRE

    2016-01-01

    Liquid combustible fossil fuel empowers global society, yet is a non-renewable entity with time-constrained limits to supply. Advanced generation biofuel derived from microalgae could feasibly yield more than conventional biofuel crops, utilise non-agricultural land or the sea and remediate atmospheric carbon dioxide and anthropogenic waste. However, technical and economical limits have so far prevented the successful implementation of microalgae biofuels. This thesis exempl...

  4. Data Integration for the Generation of High Resolution Reservoir Models

    Energy Technology Data Exchange (ETDEWEB)

    Albert Reynolds; Dean Oliver; Gaoming Li; Yong Zhao; Chaohui Che; Kai Zhang; Yannong Dong; Chinedu Abgalaka; Mei Han

    2009-01-07

    The goal of this three-year project was to develop a theoretical basis and practical technology for the integration of geologic, production and time-lapse seismic data in a way that makes best use of the information for reservoir description and reservoir performance predictions. The methodology and practical tools for data integration that were developed in this research project have been incorporated into computational algorithms that are feasible for large scale reservoir simulation models. As the integration of production and seismic data require calibrating geological/geostatistical models to these data sets, the main computational tool is an automatic history matching algorithm. The following specific goals were accomplished during this research. (1) We developed algorithms for calibrating the location of the boundaries of geologic facies and the distribution of rock properties so that production and time-lapse seismic data are honored. (2) We developed and implemented specific procedures for conditioning reservoir models to time-lapse seismic data. (3) We developed and implemented algorithms for the characterization of measurement errors which are needed to determine the relative weights of data when conditioning reservoir models to production and time-lapse seismic data by automatic history matching. (4) We developed and implemented algorithms for the adjustment of relative permeability curves during the history matching process. (5) We developed algorithms for production optimization which accounts for geological uncertainty within the context of closed-loop reservoir management. (6) To ensure the research results will lead to practical public tools for independent oil companies, as part of the project we built a graphical user interface for the reservoir simulator and history matching software using Visual Basic.

  5. Integration of renewable generation and elastic loads into distribution grids

    CERN Document Server

    Ardakanian, Omid; Rosenberg, Catherine

    2016-01-01

    This brief examines the challenges of integrating distributed energy resources and high-power elastic loads into low-voltage distribution grids, as well as the potential for pervasive measurement. It explores the control needed to address these challenges and achieve various system-level and user-level objectives. A mathematical framework is presented for the joint control of active end-nodes at scale, and extensive numerical simulations demonstrate that proper control of active end-nodes can significantly enhance reliable and economical operation of the power grid.

  6. On Finitely Generated Ring Extensions of Integral Domains

    Institute of Scientific and Technical Information of China (English)

    Susumu Oda; Ken-ichi Yoshida

    2001-01-01

    Let R be a Noetherian domain and L an algebraic extension of the quotient field K of R. For algebraic elements α1,..., αn over R, let R =∩eλ∈△ R[αeλ1 …,αeλnn], where △ = {eλ = (eλ1,… ,eλn) |eλi = ±1}. First, it is shown that if α1,… ,αn are primitive elements over R, thenR[α1,..., αn] is flat over R. Second, it is proved that if α1,…, αn ∈ L are primitive over R and αi is anti-integral over R for each i, thenR and R is LCM-stable over R for each i, then R is flat over R.

  7. Integrating Communication and Navigation: Next Generation Broadcast Service (NGBS)

    Science.gov (United States)

    Donaldson, Jennifer

    2017-01-01

    NASA Goddard has been investing in technology demonstrations of a beacon service, now called Next Generation Broadcast Services (NGBS). NGBS is a global, space-based, communications and navigation service for users of Global Navigation Satellite Systems (GNSS) and the Tracking and Data Relay Satellite System (TDRSS). NGBS will provide an S-band beacon messaging source and radio navigation available to users at orbital altitudes 1400 km and below, increasing the autonomy and resiliency of onboard communication and navigation. NGBS will deliver both one-way radiometric (Doppler and pseudorange) and fast forward data transport services to users. Portions of the overall forward data volume will be allocated for fixed message types while the remaining data volume will be left for user forward command data. The NGBS signal will reside within the 2106.43 MHz spectrum currently allocated for the Space Networks multiple access forward (MAF) service and a live service demonstration is currently being planned via the 2nd and 3rd generation TDRS satellites.

  8. Automatic Tool Path Generation for Robot Integrated Surface Sculpturing System

    Science.gov (United States)

    Zhu, Jiang; Suzuki, Ryo; Tanaka, Tomohisa; Saito, Yoshio

    In this paper, a surface sculpturing system based on 8-axis robot is proposed, the CAD/CAM software and tool path generation algorithm for this sculpturing system are presented. The 8-axis robot is composed of a 6-axis manipulator and a 2-axis worktable, it carves block of polystyrene foams by heated cutting tools. Multi-DOF (Degree of Freedom) robot benefits from the faster fashion than traditional RP (Rapid Prototyping) methods and more flexibility than CNC machining. With its flexibility driven from an 8-axis configuration, as well as efficient custom-developed software for rough cutting and finish cutting, this surface sculpturing system can carve sculptured surface accurately and efficiently.

  9. Diminished white matter integrity in patients with systemic lupus erythematosus

    Directory of Open Access Journals (Sweden)

    Tobias Schmidt-Wilcke

    2014-01-01

    Conclusions: Our data suggest that changes in regional white matter integrity, in terms of a decrease in FA, are present not only in NPSLE patients, but also in non-NPSLE patients, though to a lesser degree. We also demonstrate that the way statistical maps are corrected for multiple comparisons has a profound influence on whether alterations in white matter integrity in non-NPSLE patients are deemed significant.

  10. Second Generation Integrated Composite Analyzer (ICAN) Computer Code

    Science.gov (United States)

    Murthy, Pappu L. N.; Ginty, Carol A.; Sanfeliz, Jose G.

    1993-01-01

    This manual updates the original 1986 NASA TP-2515, Integrated Composite Analyzer (ICAN) Users and Programmers Manual. The various enhancements and newly added features are described to enable the user to prepare the appropriate input data to run this updated version of the ICAN code. For reference, the micromechanics equations are provided in an appendix and should be compared to those in the original manual for modifications. A complete output for a sample case is also provided in a separate appendix. The input to the code includes constituent material properties, factors reflecting the fabrication process, and laminate configuration. The code performs micromechanics, macromechanics, and laminate analyses, including the hygrothermal response of polymer-matrix-based fiber composites. The output includes the various ply and composite properties, the composite structural response, and the composite stress analysis results with details on failure. The code is written in FORTRAN 77 and can be used efficiently as a self-contained package (or as a module) in complex structural analysis programs. The input-output format has changed considerably from the original version of ICAN and is described extensively through the use of a sample problem.

  11. Completely Integrable Hamiltonian Systems Generated by Poisson Structures in R3

    Institute of Scientific and Technical Information of China (English)

    LEI De-Chao; ZHANG Xiang

    2005-01-01

    @@ The completely integrable Hamiltonian systems have been applied to physics and mechanics intensively. We generate a family of completely integrable Hamiltonian systems from some kinds of exact Poisson structures in R3 by the realization of the Poisson algebra. Moreover, we prove that there is a Poisson algebra which cannot be realized by an exact Poisson structure.

  12. Scaling Up Renewable Energy Generation: Aligning Targets and Incentives with Grid Integration Considerations, Greening The Grid

    Energy Technology Data Exchange (ETDEWEB)

    Katz, Jessica; Cochran, Jaquelin

    2015-05-27

    Greening the Grid provides technical assistance to energy system planners, regulators, and grid operators to overcome challenges associated with integrating variable renewable energy into the grid. This document, part of a Greening the Grid toolkit, provides power system planners with tips to help secure and sustain investment in new renewable energy generation by aligning renewable energy policy targets and incentives with grid integration considerations.

  13. Message passing for integrating and assessing renewable generation in a redundant power grid

    Energy Technology Data Exchange (ETDEWEB)

    Zdeborova, Lenka [Los Alamos National Laboratory; Backhaus, Scott [Los Alamos National Laboratory; Chertkov, Michael [Los Alamos National Laboratory

    2009-01-01

    A simplified model of a redundant power grid is used to study integration of fluctuating renewable generation. The grid consists of large number of generator and consumer nodes. The net power consumption is determined by the difference between the gross consumption and the level of renewable generation. The gross consumption is drawn from a narrow distribution representing the predictability of aggregated loads, and we consider two different distributions representing wind and solar resources. Each generator is connected to D consumers, and redundancy is built in by connecting R {le} D of these consumers to other generators. The lines are switchable so that at any instance each consumer is connected to a single generator. We explore the capacity of the renewable generation by determining the level of 'firm' generation capacity that can be displaced for different levels of redundancy R. We also develop message-passing control algorithm for finding switch sellings where no generator is overloaded.

  14. Message passing for integrating and assessing renewable generation in a redundant power grid

    Energy Technology Data Exchange (ETDEWEB)

    Zdeborova, Lenka [Los Alamos National Laboratory; Backhaus, Scott [Los Alamos National Laboratory; Chertkov, Michael [Los Alamos National Laboratory

    2009-01-01

    A simplified model of a redundant power grid is used to study integration of fluctuating renewable generation. The grid consists of large number of generator and consumer nodes. The net power consumption is determined by the difference between the gross consumption and the level of renewable generation. The gross consumption is drawn from a narrow distribution representing the predictability of aggregated loads, and we consider two different distributions representing wind and solar resources. Each generator is connected to D consumers, and redundancy is built in by connecting R {le} D of these consumers to other generators. The lines are switchable so that at any instance each consumer is connected to a single generator. We explore the capacity of the renewable generation by determining the level of 'firm' generation capacity that can be displaced for different levels of redundancy R. We also develop message-passing control algorithm for finding switch sellings where no generator is overloaded.

  15. Multi-objective Generation Expansion Planning for Integrating Largescale Wind Generation

    DEFF Research Database (Denmark)

    Zhang, Chunyu; Ding, Yi; Kang, Chongqing

    2013-01-01

    Due to the growth of energy consumption, the extensive use of conventional fossil fuels from the exhaustible resources and the environmental concerns, high penetration of renewable energy resources is considerably observed worldwide. Wind power generation is holding the first rank in terms of uti...... of utilization and importance. In the last decade, the growth rate of the global installed wind capacity has been about 30% per annum. Denmark, Germany, and Spain are the first few countries generating 20% of their electricity from wind turbines....

  16. Integration of a Pulse Generator on Chip Into a Compact Ultrawideband Antenna

    NARCIS (Netherlands)

    Vorobyov, A.V.; Bagga, S.; Yarovoy, A.G.; Haddad, S.A.P.; Serdijn, W.A.; Long, J.R.; Irahhauten, Z.; Ligthart, L.P.

    For impulse radio ultrawideband communications an “antenna plus generator” system is co-designed and an on chip generator is integrated into the antenna. This approach does away with the need for intermediate transmission lines conventionally placed between an RF device/generator and an antenna and

  17. Integration of a Pulse Generator on Chip Into a Compact Ultrawideband Antenna

    NARCIS (Netherlands)

    Vorobyov, A.V.; Bagga, S.; Yarovoy, A.G.; Haddad, S.A.P.; Serdijn, W.A.; Long, J.R.; Irahhauten, Z.; Ligthart, L.P.

    For impulse radio ultrawideband communications an “antenna plus generator” system is co-designed and an on chip generator is integrated into the antenna. This approach does away with the need for intermediate transmission lines conventionally placed between an RF device/generator and an antenna and

  18. Integrative Medicine Preferences Among Coccidioidomycosis (Valley Fever) Patients.

    Science.gov (United States)

    Short, Jack H; Bradley, Constance; Blair, Janis E; Stewart, Terry D; Burns, Mark W; Patron, Roberto L; Millstine, Denise M

    2017-02-01

    To understand the extent and modalities of integrative medicine strategies that patients with coccidioidomycosis (valley fever) have incorporated into their treatment regimens. A direct patient survey was distributed, with 100 unique responses, at a single infectious diseases clinic at an academic medical center in Arizona. Eligible patients, defined as those with confirmed coccidioidomycosis or currently under evaluation, were polled on their personal use of 36 integrative medicine modalities. Patients were also asked to indicate their level of fatigue on a 10-point scale in an attempt to correlate levels of fatigue to use of specific integrative medicine modalities. Of the patients surveyed, 64% had used at least one integrative medicine modality, and 53% used two or more, along with conventional medical therapy. The top three modalities were nutrition (39%), massage (27%), and breathing exercises (26%). The mean reported fatigue level was 4.7 on a 10-point scale, with a standard deviation of 3.0. There was no statistically significant association between use of a specific modality and reported level of fatigue. Nearly two thirds of patients (64%) surveyed had used at least one integrative medicine modality throughout the course of their therapy. Clinicians are probably unaware of the extent to which many patients, including this population, have embraced integrative medicine. Awareness of patients' goal and preferences is valuable in shared clinical decision making.

  19. Upon Generating Discrete Expanding Integrable Models of the Toda Lattice Systems and Infinite Conservation Laws

    Science.gov (United States)

    Zhang, Yufeng; Zhang, Xiangzhi; Wang, Yan; Liu, Jiangen

    2017-01-01

    With the help of R-matrix approach, we present the Toda lattice systems that have extensive applications in statistical physics and quantum physics. By constructing a new discrete integrable formula by R-matrix, the discrete expanding integrable models of the Toda lattice systems and their Lax pairs are generated, respectively. By following the constructing formula again, we obtain the corresponding (2+1)-dimensional Toda lattice systems and their Lax pairs, as well as their (2+1)-dimensional discrete expanding integrable models. Finally, some conservation laws of a (1+1)-dimensional generalised Toda lattice system and a new (2+1)-dimensional lattice system are generated, respectively.

  20. Integrated bistable generator for wideband energy harvesting with optimized synchronous electric charge extraction circuit

    Science.gov (United States)

    Liu, Weiqun; Badel, Adrien; Formosa, Fabien; Wu, Yipeng; Agbossou, Amen

    2013-12-01

    Bistable generators have been proposed as potential solutions to the challenge of variable vibration frequencies. In the authors' previous works, a specific BSM (Buckled-Spring-Mass) harvester architecture has been suggested. It presents some properties of interests: simplicity, compactness and wide bandwidth. Using a normalized model of the BSM generator for design and optimization at different scales, this paper presents a new integrated BSM bistable generator design with the OSECE (Optimized Synchronous Electric Charge Extraction) technique which is used for broadband energy harvesting. The experimental results obtained from an initial prototype device show that the BSM generator with the OSECE circuit exhibits better performance for low coupling cases or reverse sweep excitations. This is also confirmed by simulations for the proposed integrated generator. Good applications prospective is expected for the bistable generator with the nonlinear OSECE circuit.

  1. Integrated Patient Education on U.S. Hospital Web Sites.

    Science.gov (United States)

    Huang, Edgar; Wu, Kerong; Edwards, Kelsey

    2016-01-01

    Based on a census of the 2015 Most Wired Hospitals, this content analysis aimed to find out how patient education has been integrated on these best IT hospitals' Web sites to serve the purposes of marketing and meeting online visitors' needs. This study will help hospitals to understand where the weaknesses are in their interactive patient education implementation and come up with a smart integration strategy. The study found that 70% of these hospitals had adopted interactive patient education contents, 76.6% of such contents were from a third-party developer, and only 20% of the hospitals linked their patient education contents to one or more of the hospital's resources while 26% cross-references such contents. The authors concluded that more hospitals should take advantage of modern information communication technology to cross-reference their patient education contents and to integrate such contents into their overall online marketing strategy to benefit patients and themselves.

  2. Integrity evaluation for steam generator tube of system integrated modular advanced reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J. S.; Jin, T. E. [KOPEC, Taejon (Korea, Republic of); Jeong, M. J.; Choi, Y. H.; Jeo, J. C. [KINS, Taejon (Korea, Republic of)

    2003-10-01

    In this study, the structural integrity for SG tube of system integrated modular advanced reactor, which is subjected to dominant external pressure as well as helical type, is evaluated using the commercial finite element package ABAQUS and the American petrochemical industry code API 579 Appendix B. First of all, the crack behavior under the assumption of local heating is assessed using ABAQUS. And, the buckling behavior of tube with 40% wall thinning is assessed using API 579 Appendix B. As a result, it is found that the crack closure phenomenon occurs under external pressure and the buckling doesn't occur even if 40% wall thinning exists in tube.

  3. Composition Modeling and Equivalence of an Integrated Power Generation System of Wind, Photovoltaic and Energy Storage Unit

    Institute of Scientific and Technical Information of China (English)

    WANG Haohuai; TANG Yong; HOU Junxian; ZOU Jiangfeng; LIANGShuang; SU Feng

    2011-01-01

    The characteristic of wind and solar generation is random and fluctuant. In order to improve their generation performance, the integrated power generation of wind, photovoltaic (PV) and energy storage is a focus in the study. In this paper,

  4. Developing an innovative, integrated care pathway for PMV patients

    OpenAIRE

    Garcia Gomes, Vanda Maria; Butzke, Bettina; Kubitschek, Martin

    2016-01-01

    Background: In the traditional care pathway for prolonged mechanically ventilated (PMV) patients, the patients often progress from an intensive care unit (ICU) directly to their home or to an unspecialised nursing home setting. In these settings, specialised offerings for PMV patients such as round-the-clock respiratory rehabilitation and weaning programmes are usually not being offered. Therefore in the traditional pathway, PMV patients do not receive the integrated rehabilitation and therap...

  5. Molecular characterization of transgene integration by next-generation sequencing in transgenic cattle.

    Directory of Open Access Journals (Sweden)

    Ran Zhang

    Full Text Available As the number of transgenic livestock increases, reliable detection and molecular characterization of transgene integration sites and copy number are crucial not only for interpreting the relationship between the integration site and the specific phenotype but also for commercial and economic demands. However, the ability of conventional PCR techniques to detect incomplete and multiple integration events is limited, making it technically challenging to characterize transgenes. Next-generation sequencing has enabled cost-effective, routine and widespread high-throughput genomic analysis. Here, we demonstrate the use of next-generation sequencing to extensively characterize cattle harboring a 150-kb human lactoferrin transgene that was initially analyzed by chromosome walking without success. Using this approach, the sites upstream and downstream of the target gene integration site in the host genome were identified at the single nucleotide level. The sequencing result was verified by event-specific PCR for the integration sites and FISH for the chromosomal location. Sequencing depth analysis revealed that multiple copies of the incomplete target gene and the vector backbone were present in the host genome. Upon integration, complex recombination was also observed between the target gene and the vector backbone. These findings indicate that next-generation sequencing is a reliable and accurate approach for the molecular characterization of the transgene sequence, integration sites and copy number in transgenic species.

  6. Overlap between empathy, teamwork and integrative approach to patient care.

    Science.gov (United States)

    Hojat, Mohammadreza; Bianco, Joseph A; Mann, Douglas; Massello, David; Calabrese, Leonard H

    2014-10-14

    Abstract Background: Empathy, teamwork and an integrative approach to patient care share common denominators such as interpersonal skills and understanding patients' concerns. Thus, a significant overlap among measures of empathy, teamwork and integrative approach to patient care is expected. Aim: This study examined the magnitude of overlap (shared variance) among three measures of empathy, teamwork and an integrative approach to patient care. Methods: Three-hundred seventy-three medical students completed the Jefferson Scale of Empathy (JSE), the Jefferson Scale of Attitudes toward Physician-Nurse Collaboration (JSAPNC) and Integrative Patient Care (IPC). Results: Significant overlaps were found among the three measures (p < 0.01), ranging from 13% (r = 0.36), between JSAPNC and IPC, to 18% (r = 0.42), between JSE and JSAPNC, and 30% (r = 0.55) between JSE and IPC for the total sample. Pattern of findings was similar for men and women. In a multiple regression model, a significant multiple correlation (R = 0.60, p < 0.01) was obtained in correlating scores on the JSE with the JSAPNC, and IPC scores, controlling for gender effect (men = 0 and women = 1). Conclusions: The significant links between empathy, teamwork and IPC support the common denominator assumption. The findings that IPC shares common variance with empathy and teamwork have implications for medical education curriculum, suggesting that implementation of integrative patient care can improve empathic engagement in patient care and orientation toward teamwork.

  7. Next generation sequencing in sporadic retinoblastoma patients reveals somatic mosaicism.

    Science.gov (United States)

    Amitrano, Sara; Marozza, Annabella; Somma, Serena; Imperatore, Valentina; Hadjistilianou, Theodora; De Francesco, Sonia; Toti, Paolo; Galimberti, Daniela; Meloni, Ilaria; Cetta, Francesco; Piu, Pietro; Di Marco, Chiara; Dosa, Laura; Lo Rizzo, Caterina; Carignani, Giulia; Mencarelli, Maria Antonietta; Mari, Francesca; Renieri, Alessandra; Ariani, Francesca

    2015-11-01

    In about 50% of sporadic cases of retinoblastoma, no constitutive RB1 mutations are detected by conventional methods. However, recent research suggests that, at least in some of these cases, there is somatic mosaicism with respect to RB1 normal and mutant alleles. The increased availability of next generation sequencing improves our ability to detect the exact percentage of patients with mosaicism. Using this technology, we re-tested a series of 40 patients with sporadic retinoblastoma: 10 of them had been previously classified as constitutional heterozygotes, whereas in 30 no RB1 mutations had been found in lymphocytes. In 3 of these 30 patients, we have now identified low-level mosaic variants, varying in frequency between 8 and 24%. In 7 out of the 10 cases previously classified as heterozygous from testing blood cells, we were able to test additional tissues (ocular tissues, urine and/or oral mucosa): in three of them, next generation sequencing has revealed mosaicism. Present results thus confirm that a significant fraction (6/40; 15%) of sporadic retinoblastoma cases are due to postzygotic events and that deep sequencing is an efficient method to unambiguously distinguish mosaics. Re-testing of retinoblastoma patients through next generation sequencing can thus provide new information that may have important implications with respect to genetic counseling and family care.

  8. Patient Safety and Workplace Bullying: An Integrative Review.

    Science.gov (United States)

    Houck, Noreen M; Colbert, Alison M

    Workplace bullying is strongly associated with negative nursing outcomes, such as work dissatisfaction, turnover, and intent to leave; however, results of studies examining associations with specific patient safety outcomes are limited or nonspecific. This integrative review explores and synthesizes the published articles that address the impact of workplace nurse bullying on patient safety.

  9. Y-branch integrated dual wavelength laser diode for microwave generation by sideband injection locking.

    Science.gov (United States)

    Huang, Jin; Sun, Changzheng; Xiong, Bing; Luo, Yi

    2009-11-01

    A Y-branch integrated dual wavelength laser diode is fabricated for optical microwave generation based on the principle of sideband injection locking. The device integrates a master laser and a slave laser with associated Y-branch coupler. By directly modulating the master laser near its relaxation resonance frequency, multiple sidebands are generated due to enhanced modulation nonlinearity. Beat signal with high spectral purity is obtained by injection locking the slave laser to one of the modulation sidebands. A millimeter-wave carrier of 42-GHz with a phase noise of -94.6 dBc/Hz at 10 kHz offset is demonstrated.

  10. Note: Fully integrated 3.2 Gbps quantum random number generator with real-time extraction

    Science.gov (United States)

    Zhang, Xiao-Guang; Nie, You-Qi; Zhou, Hongyi; Liang, Hao; Ma, Xiongfeng; Zhang, Jun; Pan, Jian-Wei

    2016-07-01

    We present a real-time and fully integrated quantum random number generator (QRNG) by measuring laser phase fluctuations. The QRNG scheme based on laser phase fluctuations is featured for its capability of generating ultra-high-speed random numbers. However, the speed bottleneck of a practical QRNG lies on the limited speed of randomness extraction. To close the gap between the fast randomness generation and the slow post-processing, we propose a pipeline extraction algorithm based on Toeplitz matrix hashing and implement it in a high-speed field-programmable gate array. Further, all the QRNG components are integrated into a module, including a compact and actively stabilized interferometer, high-speed data acquisition, and real-time data post-processing and transmission. The final generation rate of the QRNG module with real-time extraction can reach 3.2 Gbps.

  11. NaBH4 generator integrated with energy conversion device based on hydrogen combustion

    Science.gov (United States)

    Netskina, O. V.; Fursenko, R. V.; Komova, O. V.; Odintsov, E. S.; Simagina, V. I.

    2015-01-01

    A thermoelectric energy conversion device operating on the heat generated by a hydrogen diffusion microflame has been developed. For the first time, a NaBH4 hydrogen generator has been employed as a source of fuel for such type of power generator. A 1%Ru-3%Co/Sibunit catalyst ensures hydrogen generation at a rate of 3 cm3 s-1 during 3 h. Power and efficiency characteristics of the integrated system consisting of a hydrogen generator and an energy converter based on combustion technologies have been studied experimentally. The total efficiency and the generated power of the system were measured to achieve values of up to 1.23% and 0.25 W, respectively. Ways to further improve the system's power output and efficiency characteristics have been discussed.

  12. Network Regulation and Support Schemes - How Policy Interactions Affect the Integration of Distributed Generation

    DEFF Research Database (Denmark)

    Ropenus, Stephanie; Jacobsen, Henrik; Schröder, Sascha Thorsten

    2011-01-01

    -off between the incentives for these two market agents to facilitate the integration of distributed generation. Secondly, the interaction of these policy dimensions is analyzed, including case studies based on five EU Member States. Aspects of operational nature and investments in grid and distributed...... generation facilities are covered. The question in which policy segment to incorporate locational signals is at the heart of the debate...

  13. Integrated patient and tumor genetic testing for individualized cancer therapy.

    Science.gov (United States)

    Hertz, D L; McLeod, H L

    2016-02-01

    Tumor genome analysis is transforming cancer treatment by enabling identification of specific oncogenic drivers and selection of effective targeted agents. Meanwhile, patient genome analysis is being employed across therapeutic areas to inform selection of appropriate drugs and doses for treatment safety. Integration of patient genome analysis concurrent with preemptive tumor genetic testing will enable oncologists to make informed treatment decisions to select the right dose of the right drug for each patient and their tumor.

  14. Arterial Stiffness in Patients Taking Second-generation Antipsychotics

    Science.gov (United States)

    Fındıklı, Ebru; Gökçe, Mustafa; Nacitarhan, Vedat; Camkurt, Mehmet Akif; Fındıklı, Hüseyin Avni; Kardaş, Selçuk; Şahin, Merve Coşgun; Karaaslan, Mehmet Fatih

    2016-01-01

    Objective That treatment with second-generation antipsychotics (SGAs) causes metabolic side effects and atherosclerosis in patients with schizophrenia and bipolar disorder (BD) is well-known. Increased arterial stiffness is an important marker of arteriosclerosis and has been identified as an independent risk factor for cardiovascular diseases. We measured pulse wave velocity (PWV) as a marker of arteriosclerosis in patients with schizophrenia and BD who use SGAs. Methods Patients and controls were collected from our psychiatry outpatient clinics or family medicine. Mental illness was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition. Mean age, gender, systolic and diastolic blood pressure, body mass index, Framingham risk score (FRS), etc. were determined. Simultaneous electrocardiography and pulse wave were recorded with an electromyography device. The photo-plethysmographic method was used to record the pulse wave. Inclusion criteria included use of SGAs for at least the last six months. Patients with diseases that are known to cause stiffness and the use of typical antipsychotics were excluded. Results Ninety-six subject (56 patients, 40 controls) were included in our study. There were 49 females, 47 males. Patients had schizophrenia (n=17) and BD (n=39). Their treatments were quetiapine (n=15), risperidone (n=13), olanzapine (n=15), and aripiprazole (n=13). Although differences in mean age, gender, and FRS in the patient and control groups were not statistically significant (p=1), PWV was greater in patients in the antipsychotic group (p=0.048). Conclusion This study supported the liability to stiffness in patients with schizophrenia and BD. Using SGAs may contribute to arterial stiffness in these patients. PMID:27776389

  15. Building the Capacity for Climate Services: Thoughts on Training Next Generation Climate Science Integrators

    Science.gov (United States)

    Garfin, G. M.; Brugger, J.; Gordon, E. S.; Barsugli, J. J.; Rangwala, I.; Travis, W.

    2015-12-01

    For more than a decade, stakeholder needs assessments and reports, including the recent National Climate Assessment, have pointed out the need for climate "science translators" or "science integrators" who can help bridge the gap between the cultures and contexts of researchers and decision-makers. Integration is important for exchanging and enhancing knowledge, building capacity to use climate information in decision making, and fostering more robust planning for decision-making in the context of climate change. This talk will report on the characteristics of successful climate science integrators, and a variety of models for training the upcoming generation of climate science integrators. Science integration characteristics identified by an experienced vanguard in the U.S. include maintaining credibility in both the scientific and stakeholder communities, a basic respect for stakeholders demonstrated through active listening, and a deep understanding of the decision-making context. Drawing upon the lessons of training programs for Cooperative Extension, public health professionals, and natural resource managers, we offer ideas about training next generation climate science integrators. Our model combines training and development of skills in interpersonal relations, communication of science, project implementation, education techniques and practices - integrated with a strong foundation in disciplinary knowledge.

  16. Does integrated governance lead to integrated patient care? Findings from the innovation forum.

    Science.gov (United States)

    Beech, Roger; Henderson, Catherine; Ashby, Sue; Dickinson, Angela; Sheaff, Rod; Windle, Karen; Wistow, Gerald; Knapp, Martin

    2013-11-01

    Good integration of services that aim to reduce avoidable acute hospital bed use by older people requires frontline staff to be aware of service options and access them in a timely manner. In three localities where closer inter-organisational integration was taking place, this research sought patients' perceptions of the care received across and within organisational boundaries. Between February and July 2008, qualitative methods were used to map the care journeys of 18 patients (six from each site). Patient interviews (46) covered care received before, at the time of and following a health crisis. Additional interviews (66) were undertaken with carers and frontline staff. Grounded theory-based approaches showed examples of well-integrated care against a background of underuse of services for preventing health crises and a reliance on 'traditional' referral patterns and services at the time of a health crisis. There was scope to raise both practitioner and patient awareness of alternative care options and to expand the availability and visibility of care 'closer to home' services such as rapid response teams. Concerns voiced by patients centred on the adequacy of arrangements for organising ongoing care, while family members reported being excluded from discussions about care arrangements and the roles they were expected to play. The coordination of care was also affected by communication difficulties between practitioners (particularly across organisational boundaries) and a lack of compatible technologies to facilitate information sharing. Finally, closer organisational integration seemed to have limited impact on care at the patient/practitioner interface. To improve care experienced by patients, organisational integration needs to be coupled with vertical integration within organisations to ensure that strategic goals influence the actions of frontline staff. As they experience the complete care journey, feedback from patients can play an important role in the

  17. Generation of open biomedical datasets through ontology-driven transformation and integration processes.

    Science.gov (United States)

    Carmen Legaz-García, María Del; Miñarro-Giménez, José Antonio; Menárguez-Tortosa, Marcos; Fernández-Breis, Jesualdo Tomás

    2016-06-03

    Biomedical research usually requires combining large volumes of data from multiple heterogeneous sources, which makes difficult the integrated exploitation of such data. The Semantic Web paradigm offers a natural technological space for data integration and exploitation by generating content readable by machines. Linked Open Data is a Semantic Web initiative that promotes the publication and sharing of data in machine readable semantic formats. We present an approach for the transformation and integration of heterogeneous biomedical data with the objective of generating open biomedical datasets in Semantic Web formats. The transformation of the data is based on the mappings between the entities of the data schema and the ontological infrastructure that provides the meaning to the content. Our approach permits different types of mappings and includes the possibility of defining complex transformation patterns. Once the mappings are defined, they can be automatically applied to datasets to generate logically consistent content and the mappings can be reused in further transformation processes. The results of our research are (1) a common transformation and integration process for heterogeneous biomedical data; (2) the application of Linked Open Data principles to generate interoperable, open, biomedical datasets; (3) a software tool, called SWIT, that implements the approach. In this paper we also describe how we have applied SWIT in different biomedical scenarios and some lessons learned. We have presented an approach that is able to generate open biomedical repositories in Semantic Web formats. SWIT is able to apply the Linked Open Data principles in the generation of the datasets, so allowing for linking their content to external repositories and creating linked open datasets. SWIT datasets may contain data from multiple sources and schemas, thus becoming integrated datasets.

  18. Indianapolis I3: the third generation Integrated Advanced Information Management Systems.

    Science.gov (United States)

    McGowan, Julie J; Overhage, J Marc; Barnes, Mike; McDonald, Clement J

    2004-04-01

    In 2001, the Regenstrief Institute for Health Care and the Indiana University School of Medicine (IUSM) began an IAIMS planning effort to create a vision and a tactical plan for the first Integrated Advanced Information Management Systems (IAIMS) implementation to cross a large area and include unaffiliated institutions. A number of elements made this planning effort unique. Among these elements were the existence of a network infrastructure that supported the Indianapolis Network for Patient Care, the existence of a mature medical informatics program at the Regenstrief Institute, and the existence of a wide-area knowledge network fostered by the IUSM libraries. However, the leadership for a strong information technology role in the IUSM that could promote collaboration in support of education and research across the diverse Indianapolis hospital systems had been lacking. By bringing together various groups, each with a commitment to improve health care quality and public health across the Indianapolis metropolitan area, regardless of individual institutional affiliation, the strategic directions for I3-Indianapolis IAIMS Initiative have been defined and the foundations for a third generation IAIMS construct have been laid in Indianapolis, Indiana.

  19. Let's move our next generation of patients toward healthy behaviors

    Directory of Open Access Journals (Sweden)

    Nsiah-Kumi PA

    2012-04-01

    Full Text Available Phyllis A Nsiah-Kumi1,2, Lydia Y Kang1, Jennifer R Parker1,21General Internal Medicine, 2Internal Medicine-Pediatrics Program, University of Nebraska Medical Center, Omaha, NE, USAAbstract: Health care professionals in all disciplines who care for adults have the opportunity to improve the health of the next generation. The prevalence of overweight and obesity continues to rise in children and adults around the world. As providers caring for adults, our primary goal is to address the health needs of our patients. However, it is important to recognize that counseling our patients who have children can lead them to adopt model behaviors that will be imitated by their children (and therefore improve the weight status and reduce health risks for their children. Additionally, many patients are more motivated to adopt behavior changes for the sake of their children than for their own health. All of 2012's 11-year-old children may be our adult patients in 10 years – especially if they have already developed weight-related health problems. Anything we do to address childhood obesity is an investment in the health of our patient panels, both now and in the future. While counseling may feel futile at times, there is strong evidence for the power of counseling to shape patient behavior. Counseling adult patients about healthy behaviors will benefit not only our patients today but our patients in the future as well.Keywords: obesity, counseling, provider, lifestyle change, parental modeling, self-efficacy

  20. Generating patient-specific pulmonary vascular models for surgical planning

    Science.gov (United States)

    Murff, Daniel; Co-Vu, Jennifer; O'Dell, Walter G.

    2015-03-01

    Each year in the U.S., 7.4 million surgical procedures involving the major vessels are performed. Many of our patients require multiple surgeries, and many of the procedures include "surgical exploration". Procedures of this kind come with a significant amount of risk, carrying up to a 17.4% predicted mortality rate. This is especially concerning for our target population of pediatric patients with congenital abnormalities of the heart and major pulmonary vessels. This paper offers a novel approach to surgical planning which includes studying virtual and physical models of pulmonary vasculature of an individual patient before operation obtained from conventional 3D X-ray computed tomography (CT) scans of the chest. These models would provide clinicians with a non-invasive, intricately detailed representation of patient anatomy, and could reduce the need for invasive planning procedures such as exploratory surgery. Researchers involved in the AirPROM project have already demonstrated the utility of virtual and physical models in treatment planning of the airways of the chest. Clinicians have acknowledged the potential benefit from such a technology. A method for creating patient-derived physical models is demonstrated on pulmonary vasculature extracted from a CT scan with contrast of an adult human. Using a modified version of the NIH ImageJ program, a series of image processing functions are used to extract and mathematically reconstruct the vasculature tree structures of interest. An auto-generated STL file is sent to a 3D printer to create a physical model of the major pulmonary vasculature generated from 3D CT scans of patients.

  1. Simulation and Determination of the Laws Control of the SRM for the Integrated Starter Generator Application

    Directory of Open Access Journals (Sweden)

    M. Boudouda

    2014-05-01

    Full Text Available This paper deals with the design of an integrated starter generator system for a car flywheel based on the Switched Reluctance Machine (SRM technology. First, we discuss about the starter generator problematic following the results of our bibliography research. Secondly, we briefly remained generalities about the SRM and the determination of the laws control. In addition, we designed the converter associated to the machine using (Matlab/Simulink software in order to identify the laws control and to adapt the operating modes (motor, generator, booster, brake. Finally, simulations of the open and closed loop model were performed on the converter with the (SRM

  2. Second-harmonic generation in single-mode integrated waveguides through mode-shape modulation

    CERN Document Server

    Chiles, Jeff; Rao, Ashutosh; Malinowski, Marcin; Camacho-González, Guillermo Fernando; Fathpour, Sasan

    2016-01-01

    A simple and flexible technique for achieving quasi-phase-matching in integrated photonic waveguides without periodic poling is proposed and experimentally demonstrated, referred to as mode-shape-modulation (MSM). It employs a periodic variation of waveguide width to modulate the intensity of the pump wave, effectively suppressing out-of-phase light generation. This technique is applied to the case of second-harmonic generation in thin-film lithium niobate ridge waveguides. MSM waveguides are fabricated and characterized with pulsed-pumping in the near-infrared, showing harmonic generation at a signal wavelength of 784 nm.

  3. TimeLine: visualizing integrated patient records.

    Science.gov (United States)

    Bui, Alex A T; Aberle, Denise R; Kangarloo, Hooshang

    2007-07-01

    An increasing amount of data is now accrued in medical information systems; however, the organization of this data is still primarily driven by data source, and does not support the cognitive processes of physicians. As such, new methods to visualize patient medical records are becoming imperative in order to assist physicians with clinical tasks and medical decision-making. The TimeLine system is a problem-centric temporal visualization for medical data: information contained with medical records is reorganized around medical disease entities and conditions. Automatic construction of the TimeLine display from existing clinical repositories occurs in three steps: 1) data access, which uses an eXtensible Markup Language (XML) data representation to handle distributed, heterogeneous medical databases; 2) data mapping and reorganization, reformulating data into hierarchical, problemcentric views; and 3) data visualization, which renders the display to a target presentation platform. Leveraging past work, we describe the latter two components of the TimeLine system in this paper, and the issues surrounding the creation of medical problems lists and temporal visualization of medical data. A driving factor in the development of TimeLine was creating a foundation upon which new data types and the visualization metaphors could be readily incorporated.

  4. Silicon Photonics Integrated Circuits for 5th Generation mm-Wave Wireless Communications

    DEFF Research Database (Denmark)

    Rommel, Simon; Vegas Olmos, Juan José; Tafur Monroy, Idelfonso

    Hybrid photonic-wireless transmission schemes in the mm-wave frequency are promising candidates to enable the multi-gigabit per second data communications required from wireless and mobile networks of the 5th and future generations. Photonic integration may pave the way to practical applicability...

  5. Integration of Optically Generated Impulse Radio UWB Signals into Baseband WDM-PON

    DEFF Research Database (Denmark)

    Pham, Tien Thang; Yu, Xianbin; Dittmann, Lars

    2011-01-01

    We propose a compact integration system to simultaneously provide wireline and wireless (baseband and ultra-wide band (UWB)) services to end-users in a WDM-PON. A 1-Gbps UWB signal is optically generated and shares the same wavelength with the baseband signal. Error-free performance was achieved ...

  6. Effect of humic acids on electricity generation integrated with xylose degradation in microbial fuel cells

    DEFF Research Database (Denmark)

    Huang, Liping; Angelidaki, Irini

    2008-01-01

    Pentose and humic acids (HA) are the main components of hydrolysates, the liquid fraction produced during thermohydrolysis of lignocellulosic material. Electricity generation integrated with xylose (typical pentose) degradation as well as the effect of HA on electricity production in microbial fu...

  7. Phase-only hologram generation based on integral imaging and its enhancement in depth resolution

    Institute of Scientific and Technical Information of China (English)

    Jiwoon Yeom; Jisoo Hong; Jae-Hyun Jung; Keehoon Hong; Jae-Hyeung Park; Byoungho Lee

    2011-01-01

    We introduce a phase-only hologram generation method based on an integral imaging,and propose an enhancement method in representable depth interval.The computational integral imaging reconstruction method is modified based on optical flow to obtain depth-slice images for the focused objects only.A phaseonly hologran for multiple plane images is generated using the iterative Fresnel transform algorithm.In addition,a division method in hologram plane is proposed for enhancement in the representable minimum depth interval.%We introduce a phase-only hologram generation method based on an integral imaging, and propose an enhancement method in representable depth interval. The computational integral imaging reconstruction method is modified based on optical flow to obtain depth-slice images for the focused objects only. A phase-only hologram for multiple plane images is generated using the iterative Fvesnel transform algorithm. In addition, a division method in hologram plane is proposed for enhancement in the representable minimum depth interval.

  8. Mass Market Demand Response and Variable Generation Integration Issues: A Scoping Study

    Energy Technology Data Exchange (ETDEWEB)

    Cappers, Peter; Mills, Andrew; Goldman, Charles; Wiser, Ryan; Eto, Joseph H.

    2011-09-10

    This scoping study focuses on the policy issues inherent in the claims made by some Smart Grid proponents that the demand response potential of mass market customers which is enabled by widespread implementation of Advanced Metering Infrastructure (AMI) through the Smart Grid could be the “silver bullet” for mitigating variable generation integration issues. In terms of approach, we will: identify key issues associated with integrating large amounts of variable generation into the bulk power system; identify demand response opportunities made more readily available to mass market customers through widespread deployment of AMI systems and how they can affect the bulk power system; assess the extent to which these mass market Demand Response (DR) opportunities can mitigate Variable Generation (VG) integration issues in the near-term and what electricity market structures and regulatory practices could be changed to further expand the ability for DR to mitigate VG integration issues over the long term; and provide a qualitative comparison of DR and other approaches to mitigate VG integration issues.

  9. High speed image space parallel processing for computer-generated integral imaging system.

    Science.gov (United States)

    Kwon, Ki-Chul; Park, Chan; Erdenebat, Munkh-Uchral; Jeong, Ji-Seong; Choi, Jeong-Hun; Kim, Nam; Park, Jae-Hyeung; Lim, Young-Tae; Yoo, Kwan-Hee

    2012-01-16

    In an integral imaging display, the computer-generated integral imaging method has been widely used to create the elemental images from a given three-dimensional object data. Long processing time, however, has been problematic especially when the three-dimensional object data set or the number of the elemental lenses are large. In this paper, we propose an image space parallel processing method, which is implemented by using Open Computer Language (OpenCL) for rapid generation of the elemental images sets from large three-dimensional volume data. Using the proposed technique, it is possible to realize a real-time interactive integral imaging display system for 3D volume data constructed from computational tomography (CT) or magnetic resonance imaging (MRI) data.

  10. Impact of Generator Flexibility on Electric System Costs and Integration of Renewable Energy

    Energy Technology Data Exchange (ETDEWEB)

    Palchak, D. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Denholm, P. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2014-07-01

    Flexibility of traditional generators plays an important role in accommodating the increased variability and uncertainty of wind and solar on the electric power system. Increased flexibility can be achieved with changes to operational practices or upgrades to existing generation. One challenge is in understanding the value of increasing flexibility, and how this value may change given higher levels of variable generation. This study uses a commercial production cost model to measure the impact of generator flexibility on the integration of wind and solar generators. We use a system that is based on two balancing areas in the western United States with a range of wind and solar penetrations between 15% and 60%, where instantaneous penetration of wind and solar is limited to 80%.

  11. Impact of Generator Flexibility on Electric System Costs and Integration of Renewable Energy

    Energy Technology Data Exchange (ETDEWEB)

    Palchak, D.; Denholm, P.

    2014-07-01

    Flexibility of traditional generators plays an important role in accommodating the increased variability and uncertainty of wind and solar on the electric power system. Increased flexibility can be achieved with changes to operational practices or upgrades to existing generation. One challenge is in understanding the value of increasing flexibility, and how this value may change given higher levels of variable generation. This study uses a commercial production cost model to measure the impact of generator flexibility on the integration of wind and solar generators. We use a system that is based on two balancing areas in the Western United States with a range of wind and solar penetrations between 15% and 60%, where instantaneous penetration of wind and solar is limited to 80%.

  12. An Integrated Multiperiod OPF Model with Demand Response and Renewable Generation Uncertainty

    DEFF Research Database (Denmark)

    Bukhsh, Waqquas Ahmed; Zhang, Chunyu; Pinson, Pierre

    2015-01-01

    Renewable energy sources such as wind and solar have received much attention in recent years, and large amount of renewable generation is being integrated to the electricity networks. A fundamental challenge in a power system operation is to handle the intermittent nature of the renewable...... generation. In this paper we present a stochastic programming approach to solve a multiperiod optimal power flow problem under renewable generation uncertainty. The proposed approach consists of two stages. In the first stage, operating points for the conventional power plants are determined. The second...... stage realizes generation from the renewable resources and optimally accommodates it by relying on the demand-side flexibilities and limited available flexibilities from the conventional generating units. The proposed model is illustrated on a 4-bus and a 39- bus system. Numerical results show...

  13. Integrated circuit test-port architecture and method and apparatus of test-port generation

    Energy Technology Data Exchange (ETDEWEB)

    Teifel, John

    2016-04-12

    A method and apparatus are provided for generating RTL code for a test-port interface of an integrated circuit. In an embodiment, a test-port table is provided as input data. A computer automatically parses the test-port table into data structures and analyzes it to determine input, output, local, and output-enable port names. The computer generates address-detect and test-enable logic constructed from combinational functions. The computer generates one-hot multiplexer logic for at least some of the output ports. The one-hot multiplexer logic for each port is generated so as to enable the port to toggle between data signals and test signals. The computer then completes the generation of the RTL code.

  14. Integrated circuit test-port architecture and method and apparatus of test-port generation

    Science.gov (United States)

    Teifel, John

    2016-04-12

    A method and apparatus are provided for generating RTL code for a test-port interface of an integrated circuit. In an embodiment, a test-port table is provided as input data. A computer automatically parses the test-port table into data structures and analyzes it to determine input, output, local, and output-enable port names. The computer generates address-detect and test-enable logic constructed from combinational functions. The computer generates one-hot multiplexer logic for at least some of the output ports. The one-hot multiplexer logic for each port is generated so as to enable the port to toggle between data signals and test signals. The computer then completes the generation of the RTL code.

  15. ORGANIZATION OF INTEGRATIVE CARE FOR PATIENTS WITH ONCOPATHOLOGY

    Directory of Open Access Journals (Sweden)

    G. S. Alekseeva

    2016-01-01

    Full Text Available Clinical testing (providing of integrative care was conducted to determine the methodology for the treatment and rehabilitation of patients who were previously denied in other hospitals. Defined the methodological approaches to the choice of the treatment, causing minimal harm to patients in other health care organizations were offered only symptomatic or palliative therapy.The purpose of the study:– improvement the quality of life;– increasing the terms of survival;– reduction of depressive state with confirmation of the diagnosis;– reducing the negative effects of the treatment.Patients and methods. In clinical trials 47 patients with stage IV of disease were involved, including in the integrative treatment group was 25 patients (16 women and 9 men, the group standard of treatment, 22 patients (15 women and 7 men. The group consisted of the patients with recurrences of the tumours, and patients after primary treatment at a late stage of the disease. The combination of all possible types of treatment (standard methods of treatment, immune therapy with drug “Helixor®  M”, psychological assistance was performed depending on the disease defined by the overall clinical picture and psychological readiness of patients to one or another form of therapy. The choice of the injection scheme in order to quickly transition to a maximally tolerated doses was carried out using the control functional state.Results. The use of this method in comparison with the control group showed improvement in the quality of life of patients and increase in terms of survival.Conclusion. The results that are obtained during clinical testing confirmed the positive effect of integrative treatment of patients with oncologic pathology when choosing the best course and combination of treatments, depending on the needs and course of the disease. Also the immunotherapy with drug “Helixor®  M” showed efficacy in the treatment of viral infections for patients with

  16. iCycle: Integrated, multicriterial beam angle, and profile optimization for generation of coplanar and noncoplanar IMRT plans

    Energy Technology Data Exchange (ETDEWEB)

    Breedveld, Sebastiaan; Storchi, Pascal R. M.; Voet, Peter W. J.; Heijmen, Ben J. M. [Department of Radiation Oncology, Erasmus MC Rotterdam, Groene Hilledijk 301, 3075 EA Rotterdam (Netherlands)

    2012-02-15

    Purpose: To introduce iCycle, a novel algorithm for integrated, multicriterial optimization of beam angles, and intensity modulated radiotherapy (IMRT) profiles. Methods: A multicriterial plan optimization with iCycle is based on a prescription called wish-list, containing hard constraints and objectives with ascribed priorities. Priorities are ordinal parameters used for relative importance ranking of the objectives. The higher an objective priority is, the higher the probability that the corresponding objective will be met. Beam directions are selected from an input set of candidate directions. Input sets can be restricted, e.g., to allow only generation of coplanar plans, or to avoid collisions between patient/couch and the gantry in a noncoplanar setup. Obtaining clinically feasible calculation times was an important design criterium for development of iCycle. This could be realized by sequentially adding beams to the treatment plan in an iterative procedure. Each iteration loop starts with selection of the optimal direction to be added. Then, a Pareto-optimal IMRT plan is generated for the (fixed) beam setup that includes all so far selected directions, using a previously published algorithm for multicriterial optimization of fluence profiles for a fixed beam arrangement Breedveld et al.[Phys. Med. Biol. 54, 7199-7209 (2009)]. To select the next direction, each not yet selected candidate direction is temporarily added to the plan and an optimization problem, derived from the Lagrangian obtained from the just performed optimization for establishing the Pareto-optimal plan, is solved. For each patient, a single one-beam, two-beam, three-beam, etc. Pareto-optimal plan is generated until addition of beams does no longer result in significant plan quality improvement. Plan generation with iCycle is fully automated. Results: Performance and characteristics of iCycle are demonstrated by generating plans for a maxillary sinus case, a cervical cancer patient, and a

  17. A quantum entropy source on an InP photonic integrated circuit for random number generation

    CERN Document Server

    Abellan, Carlos; Domenech, David; Muñoz, Pascual; Capmany, Jose; Longhi, Stefano; Mitchell, Morgan W; Pruneri, Valerio

    2016-01-01

    Random number generators are essential to ensure performance in information technologies, including cryptography, stochastic simulations and massive data processing. The quality of random numbers ultimately determines the security and privacy that can be achieved, while the speed at which they can be generated poses limits to the utilisation of the available resources. In this work we propose and demonstrate a quantum entropy source for random number generation on an indium phosphide photonic integrated circuit made possible by a new design using two-laser interference and heterodyne detection. The resulting device offers high-speed operation with unprecedented security guarantees and reduced form factor. It is also compatible with complementary metal-oxide semiconductor technology, opening the path to its integration in computation and communication electronic cards, which is particularly relevant for the intensive migration of information processing and storage tasks from local premises to cloud data centre...

  18. Integrated microfluidic system capable of size-specific droplet generation with size-dependent droplet separation.

    Science.gov (United States)

    Lee, Sangmin; Hong, Seok Jun; Yoo, Hyung Jung; Ahn, Jae Hyun; Cho, Dong-il Dan

    2013-06-01

    Droplet-based microfluidics is receiving much attention in biomedical research area due to its advantage in uniform size droplet generation. Our previous results have reported that droplet size plays an important role in drug delivery actuated by flagellated bacteria. Recently, many research groups have been reported the size-dependent separation of emulsion droplets by a microfluidic system. In this paper, an integrated microfluidic system is proposed to produce and sort specificsized droplets sequentially. Operation of the system relies on two microfluidic transport processes: initial generation of droplets by hydrodynamic focusing and subsequent separation of droplets by a T-junction channel. The microfluidic system is fabricated by the SU-8 rapid prototyping method and poly-di-methyl-siloxane (PDMS) replica molding. A biodegradable polymer, poly-capro-lactone (PCL), is used for the droplet material. Using the proposed integrated microfluidic system, specific-sized droplets which can be delivered by flagellated bacteria are successfully generated and obtained.

  19. Psychiatric benefits of integrative therapies in patients with cancer.

    Science.gov (United States)

    Cassileth, Barrie R

    2014-02-01

    Integrative oncology uses non-pharmacological adjuncts to mainstream care to manage physical, emotional, and psychological symptoms experienced by cancer survivors. Depression, anxiety, fatigue and pain are among the common, often burdensome symptoms that can occur in clusters, deplete patient morale, interfere with treatment plans, and hamper recovery. Patients already seek various modalities on their own to address a broad range of problems. Legitimate complementary therapies offered at major cancer institutions improve quality of life, speed recovery, and optimize patient support. They also augment the benefits of psychiatric interventions, due to their ability to increase self-awareness and improve physical and psychological conditioning. Further, these integrated therapies provide lifelong tools and develop skills that patients use well after treatment to develop self-care regimens. The active referral of patients to integrative therapies achieves three important objectives: complementary care is received from therapists experienced in working with cancer patients, visits become part of the medical record, allowing treatment teams to guide individuals in maximizing benefit, and patients are diverted from useless or harmful 'alternatives.' We review the reciprocal physical and psychiatric benefits of exercise, mind-body practices, massage, acupuncture, and music therapy for cancer survivors, and suggest how their use can augment mainstream psychiatric interventions.

  20. Integrated Power Flow and Short Circuit Calculation Method for Distribution Network with Inverter Based Distributed Generation

    Directory of Open Access Journals (Sweden)

    Shan Yang

    2016-01-01

    Full Text Available Power flow calculation and short circuit calculation are the basis of theoretical research for distribution network with inverter based distributed generation. The similarity of equivalent model for inverter based distributed generation during normal and fault conditions of distribution network and the differences between power flow and short circuit calculation are analyzed in this paper. Then an integrated power flow and short circuit calculation method for distribution network with inverter based distributed generation is proposed. The proposed method let the inverter based distributed generation be equivalent to Iθ bus, which makes it suitable to calculate the power flow of distribution network with a current limited inverter based distributed generation. And the low voltage ride through capability of inverter based distributed generation can be considered as well in this paper. Finally, some tests of power flow and short circuit current calculation are performed on a 33-bus distribution network. The calculated results from the proposed method in this paper are contrasted with those by the traditional method and the simulation method, whose results have verified the effectiveness of the integrated method suggested in this paper.

  1. Information integrity and privacy for computerized medical patient records

    Energy Technology Data Exchange (ETDEWEB)

    Gallegos, J.; Hamilton, V.; Gaylor, T.; McCurley, K.; Meeks, T.

    1996-09-01

    Sandia National Laboratories and Oceania, Inc. entered into a Cooperative Research and Development Agreement (CRADA) in November 1993 to provide ``Information Integrity and Privacy for Computerized Medical Patient Records`` (CRADA No. SC93/01183). The main objective of the project was to develop information protection methods that are appropriate for databases of patient records in health information systems. This document describes the findings and alternative solutions that resulted from this CRADA.

  2. An integrated computer-aided system for generation and evaluation of sustainable process alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Niels; Coll, Nuria; Gani, Rafiqul [CAPEC, Department of Chemical Engineering, Technical University of Denmark, 2800, Lyngby (Denmark)

    2003-10-01

    This paper presents an integrated system for generation of sustainable process alternatives with respect to new process design as well as retrofit design. The generated process alternatives are evaluated through sustainability metrics, environmental impact factors as well as inherent safety factors. The process alternatives for new process design as well as retrofit design are generated through a systematic method that is simple yet effective and is based on a recently developed path flow analysis approach. According to this approach, a set of indicators are calculated in order to pinpoint unnecessary energy and material waste costs and to identify potential design (retrofit) targets that may improve the process design (in terms of operation and cost) simultaneously with the sustainability metrics, environmental impact factors and the inherent safety factors. Only steady state design data and a database with properties of compounds, including, environmental impact factor related data and safety factor related data are needed. The integrated computer-aided system generates the necessary data if actual plant or experimental data are not available. The application of the integrated system is highlighted through a number of examples including the well-known HDA process. (orig.)

  3. Supporting Integrated Healthcare Solutions with Patients in Home Settings

    DEFF Research Database (Denmark)

    Jørgensen, Daniel Bjerring

    2016-01-01

    : The state-of-the-art of how national ICT infrastructures are designed has been identified and problems of that approach discussed. The foundation for a patient centric home/local infrastructure, to integrate data using applications and data providing applications e.g. medical devices, has been developed...

  4. Using patient lists to add value to integrated data repositories.

    Science.gov (United States)

    Wade, Ted D; Zelarney, Pearlanne T; Hum, Richard C; McGee, Sylvia; Batson, Deborah H

    2014-12-01

    Patient lists are project-specific sets of patients that can be queried in integrated data repositories (IDR's). By allowing a set of patients to be an addition to the qualifying conditions of a query, returned results will refer to, and only to, that set of patients. We report a variety of use cases for such lists, including: restricting retrospective chart review to a defined set of patients; following a set of patients for practice management purposes; distributing "honest-brokered" (deidentified) data; adding phenotypes to biosamples; and enhancing the content of study or registry data. Among the capabilities needed to implement patient lists in an IDR are: capture of patient identifiers from a query and feedback of these into the IDR; the existence of a permanent internal identifier in the IDR that is mappable to external identifiers; the ability to add queryable attributes to the IDR; the ability to merge data from multiple queries; and suitable control over user access and de-identification of results. We implemented patient lists in a custom IDR of our own design. We reviewed capabilities of other published IDRs for focusing on sets of patients. The widely used i2b2 IDR platform has various ways to address patient sets, and it could be modified to add the low-overhead version of patient lists that we describe.

  5. Medium term municipal solid waste generation prediction by autoregressive integrated moving average

    Energy Technology Data Exchange (ETDEWEB)

    Younes, Mohammad K.; Nopiah, Z. M.; Basri, Noor Ezlin A.; Basri, Hassan [Department of Civil and Structural Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor (Malaysia)

    2014-09-12

    Generally, solid waste handling and management are performed by municipality or local authority. In most of developing countries, local authorities suffer from serious solid waste management (SWM) problems and insufficient data and strategic planning. Thus it is important to develop robust solid waste generation forecasting model. It helps to proper manage the generated solid waste and to develop future plan based on relatively accurate figures. In Malaysia, solid waste generation rate increases rapidly due to the population growth and new consumption trends that characterize the modern life style. This paper aims to develop monthly solid waste forecasting model using Autoregressive Integrated Moving Average (ARIMA), such model is applicable even though there is lack of data and will help the municipality properly establish the annual service plan. The results show that ARIMA (6,1,0) model predicts monthly municipal solid waste generation with root mean square error equals to 0.0952 and the model forecast residuals are within accepted 95% confident interval.

  6. Medium term municipal solid waste generation prediction by autoregressive integrated moving average

    Science.gov (United States)

    Younes, Mohammad K.; Nopiah, Z. M.; Basri, Noor Ezlin A.; Basri, Hassan

    2014-09-01

    Generally, solid waste handling and management are performed by municipality or local authority. In most of developing countries, local authorities suffer from serious solid waste management (SWM) problems and insufficient data and strategic planning. Thus it is important to develop robust solid waste generation forecasting model. It helps to proper manage the generated solid waste and to develop future plan based on relatively accurate figures. In Malaysia, solid waste generation rate increases rapidly due to the population growth and new consumption trends that characterize the modern life style. This paper aims to develop monthly solid waste forecasting model using Autoregressive Integrated Moving Average (ARIMA), such model is applicable even though there is lack of data and will help the municipality properly establish the annual service plan. The results show that ARIMA (6,1,0) model predicts monthly municipal solid waste generation with root mean square error equals to 0.0952 and the model forecast residuals are within accepted 95% confident interval.

  7. Improved Optimization Study of Integration Strategies in Solar Aided Coal-Fired Power Generation System

    Directory of Open Access Journals (Sweden)

    Rongrong Zhai

    2015-01-01

    Full Text Available Solar aided coal-fired power generation system (SACFPGS combines solar energy and traditional coal-fired units in a particular way. This study mainly improves the solar thermal storage system. Genetic algorithm is used to optimize the SACFPGS. The best integration approach of the system, the collector area, and the corresponding thermal storage capacity to replace each high-pressure extraction are obtained when the amount of coal saving in unit solar investment per hour is at its largest. System performance before and after the improvement is compared. Results show that the improvement of the thermal storage system effectively increases the economic benefit of the integrated system.

  8. Angina in a diabetic patient: a case of integrated approach

    Directory of Open Access Journals (Sweden)

    Eugenio Roberto Cosentino

    2008-09-01

    Full Text Available Diabetes mellitus, both of type 1 and 2, is an important risk factor for the development of atherosclerosis: in diabetic patients vascular atherosclerotic complications are responsible of approximately 80% of all the deaths. There is no doubt that patients affections originating from diabetes and coronaropathy remain at high risk. For this reason it is essential to adopt an aggressive strategy of secondary prevention. We report a case of a patient with multiple risk factors for cardiovascular diseases: the successful management was due to an integrated approach that involved the general practitioner and cardiologist.

  9. Brainstorming Design for Health: Helping Patients Utilize Patient-Generated Information on the Web.

    Science.gov (United States)

    Huh, Jina; Hartzler, Andrea; Munson, Sean; Anderson, Nick; Edwards, Kelly; Gore, John L; McDonald, David; O'Leary, Jim; Parker, Andrea; Streat, Derek; Yetisgen-Yildiz, Meliha; Pratt, Wanda; Ackerman, Mark S

    2012-01-01

    Researchers and practitioners show increasing sinterest in utilizing patient-generated information on the Web. Although the HCI and CSCW communities have provided many exciting opportunities for exploring new ideas and building broad agenda in health, few venues offer a platform for interdisciplinary and collaborative brainstorming about design challenges and opportunities in this space. The goal of this workshop is to provide participants with opportunities to interact with stakeholders from diverse backgrounds and practices-researchers, practitioners, designers, programmers, and ethnographers-and together generate tangible design outcomes that utilize patient-generated information on the Web. Through small multidisciplinary group work, we will provide participants with new collaboration opportunities, understanding of the state of the art, inspiration for future work, and ideally avenues for continuing to develop research and design ideas generated at the workshop.

  10. Short optical pulse generated by integrated MQW DBR laser/EA-modulator

    Science.gov (United States)

    Chen, Young-Kai; Tanbun-Ek, Tawee; Logan, Ralph A.; Tate, A. R.; Sergent, A. M.; Wecht, K. W.; Sciortino, Paul F., Jr.; Raybon, Gregory; Froberg, Nan M.; Johnson, Anthony M.

    1994-05-01

    We report on the generation of short optical pulses by utilizing the non-linear absorption characteristics of a multiple quantum well (MQW) electro-absorption modulator, which is monolithically integrated with a MQW wavelength-tunable distributed Bragg reflector (DBR) laser on a single chip. Optical pulses as short as 39 ps and 15 ps have been generated at a repetition rate of 3 GHz and 10 GHz, respectively, with a broad tuning range of 5.4 nm near 1554 nm lasing wavelength.

  11. INTEGRATED APPROACH TO GENERATION OF PRECEDENCE RELATIONS AND PRECEDENCE GRAPHS FOR ASSEMBLY SEQUENCE PLANNING

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    An integrated approach to generation of precedence relations and precedence graphs for assembly sequence planning is presented, which contains more assembly flexibility. The approach involves two stages. Based on the assembly model, the components in the assembly can be divided into partially constrained components and completely constrained components in the first stage, and then geometric precedence relation for every component is generated automatically. According to the result of the first stage, the second stage determines and constructs all precedence graphs. The algorithms of these two stages proposed are verified by two assembly examples.

  12. Integrated Design Engineering Analysis (IDEA) Environment Automated Generation of Structured CFD Grids using Topology Methods

    Science.gov (United States)

    Kamhawi, Hilmi N.

    2012-01-01

    This report documents the work performed from March 2010 to March 2012. The Integrated Design and Engineering Analysis (IDEA) environment is a collaborative environment based on an object-oriented, multidisciplinary, distributed framework using the Adaptive Modeling Language (AML) as a framework and supporting the configuration design and parametric CFD grid generation. This report will focus on describing the work in the area of parametric CFD grid generation using novel concepts for defining the interaction between the mesh topology and the geometry in such a way as to separate the mesh topology from the geometric topology while maintaining the link between the mesh topology and the actual geometry.

  13. [Integrated management of patients with schizophrenia: beyond psychotropic drugs].

    Science.gov (United States)

    Taborda Zapata, Eliana; Montoya Gonzalez, Laura Elisa; Gómez Sierra, Natalia María; Arteaga Morales, Laura María; Correa Rico, Oscar Andrés

    2016-01-01

    Schizophrenia is a complex disease with severe functional repercussions; therefore it merits treatment which goes beyond drugs. It requires an approach that considers a diathesis-stress process that includes rehabilitation, psychotherapeutic strategies for persistent cognitive, negative and psychotic symptoms, psychoeducation of patient and communities, community adaptation strategies, such as the introduction to the work force, and the community model, such as a change in the asylum paradigm. It is necessary to establish private and public initiatives for the integrated care of schizophrenia in the country, advocating the well-being of those with the disease. The integrated management of schizophrenic patients requires a global view of the patient and his/her disease, and its development is essential. Copyright © 2015 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

  14. Patient care and management: reduced skin integrity of the foot.

    Science.gov (United States)

    Bateman, Sharon

    The development and deterioration of pressure ulcers are a frequent occurrence across all healthcare settings and specialties, posing daily challenges to the healthcare worker and unnecessary suffering to the patient. Reduced skin integrity occurs within those patients deemed high risk, particularly to the vulnerable areas such as the heel and ankle (American Physical Therapy Association (APTA), 1996). The incidence of pressure ulcers, alongside diabetes, vascular insufficiency and obesity, is on the increase, posing additional demands on current clinical resources; specialist clinics, debridement therapies and appropriate dressing management regimes. This article will focus on the heel and ankle in regards to reduced skin integrity and the positive introduction of an innovative dressing product as an adjunct to the overall care and management of this patient group.

  15. Potassium Dichromate Impact on Male Reproductive Integrity Biomarker in Rat. Two Generation Study

    Directory of Open Access Journals (Sweden)

    Jelena Rankov

    2010-05-01

    Full Text Available The aim of this study was the evaluation of Cr VI cumulative and differentiate exposure on integrity biomarker of male reproductive system. The objective was evaluation of potassium dichromate intake on genital organs and sexual accessory glands architecture in male rats from two generation. Males and females from F0 generation were exposed to potassium dichromate three months before mating. F1 generation was represented by male pups, resulted from F0 generation, exposed to potassium dichromate in utero, during suckling (via milk and water period and until sexual maturity. All the animals were divided in one control and three experimental groups, exposed to Cr VI trough drinking water, as followed E1: 25 ppm (LOAEL; E2: 50 ppm: E3: 75 ppm; control group received tap water without chromium content. The experiment was carried out with respecting legislation regarding ethics in animal experiments. The study revealed the presence of congestive and degenerative lesions in genital organs and sexual accessory glands of exposed individuals from F0 and F1 generation such as: interstitial edema, epithelial necrosis and atrophy, membrane exfoliation and necrosis. The lesions frequency and intensity were directly correlated to exposure level, the most affected being E3 group and generation, more pronounced in F1 generation.

  16. An integrated psychological strategy for advanced colorectal cancer patients

    Directory of Open Access Journals (Sweden)

    Giannarelli Diana

    2006-02-01

    Full Text Available Abstract Background There is evidence regarding the usefulness of psychosocial intervention to improve health related quality of life (HRQOL in adult cancer patients. The aim of this report is to describe an integrated approach and to evaluate its feasibility in routine clinical practice in 98 advanced colorectal cancer (ACC patients during chronomodulated chemotherapy. Methods A prospective non-randomised design was developed and applied in a cancer out-patient setting. The intervention consisted of an integrated approach, whereby the psycho-oncologist had an active role in the health care team with the physician and routinely included psychological understanding in the medical treatment program. The psychological evaluation assessed: a adaptation, awareness, psychopathological disorders through a psychodynamic interview; b anxiety and depression using the HAD scale; c subjective perception of care quality through a structured interview and d HRQOL evaluation assessment with the EORTC QLQ C30. Outcomes data were collected before and after 18 weeks of chemotherapy. Results After 18 weeks of chemotherapy a significant improvement of adaptation and awareness was observed. The HADs results showed a significant decrease in anxiety when compared to pre-treatment. The structured interview showed a significant increase of patients who positively experienced the impact of medical treatment on HRQOL, anxiety, depression, interpersonal relationships, free-time and who positively experienced the care quality. Indeed, a majority of patients positively experienced the team relationship modality during the whole treatment. All scales on the EORTC questionnaire remained unchanged during the entire treatment. Conclusion Our results suggest that it is feasible to carry out an integrated approach during chemotherapy. These results seem to support the integrated approach as a tool in aiding advanced colorectal cancer patients' ability to cope with their diagnosis

  17. Piezo-generator integrating a vertical array of GaN nanowires.

    Science.gov (United States)

    Jamond, N; Chrétien, P; Houzé, F; Lu, L; Largeau, L; Maugain, O; Travers, L; Harmand, J C; Glas, F; Lefeuvre, E; Tchernycheva, M; Gogneau, N

    2016-08-12

    We demonstrate the first piezo-generator integrating a vertical array of GaN nanowires (NWs). We perform a systematic multi-scale analysis, going from single wire properties to macroscopic device fabrication and characterization, which allows us to establish for GaN NWs the relationship between the material properties and the piezo-generation, and to propose an efficient piezo-generator design. The piezo-conversion of individual MBE-grown p-doped GaN NWs in a dense array is assessed by atomic force microscopy (AFM) equipped with a Resiscope module yielding an average output voltage of 228 ± 120 mV and a maximum value of 350 mV generated per NW. In the case of p-doped GaN NWs, the piezo-generation is achieved when a positive piezo-potential is created inside the nanostructures, i.e. when the NWs are submitted to compressive deformation. The understanding of the piezo-generation mechanism in our GaN NWs, gained from AFM analyses, is applied to design a piezo-generator operated under compressive strain. The device consists of NW arrays of several square millimeters in size embedded into spin-on glass with a Schottky contact for rectification and collection of piezo-generated carriers. The generator delivers a maximum power density of ∼12.7 mW cm(-3). This value sets the new state of the art for piezo-generators based on GaN NWs and more generally on nitride NWs, and offers promising prospects for the use of GaN NWs as high-efficiency ultra-compact energy harvesters.

  18. Zero Rare-Earth Magnet Integrated Starter-Generator Development for Military Vehicle Applications

    Science.gov (United States)

    2013-08-14

    2013 3 UNCLASSIFIED UNCLASSIFIED Introduction Consider and evaluate machine topologies for application to a 3- phase, brushless , integrated starter...high rotor thickness. 14 August 2013 12 IPM Spoke IPM AFPM TFPM SPM UNCLASSIFIED UNCLASSIFIED Non-PM Topologies • Brushless , do not require...Designs generated using 2D and 3D FEA and preliminary thermal modeling . 15 14 August 2013 UNCLASSIFIED UNCLASSIFIED Comparative Down

  19. Computer-generated integral imaging system based on straight line characteristics

    Science.gov (United States)

    Dumchykov, Igor; Piao, Yan

    2014-02-01

    Integral imaging (II) - is an autostereoscopic technique, which provides 3D-images that can be viewed in full parallax without special glasses. Obtaining volumetric images consists of pick up part and reconstruction. In this work we study principles of mapping process, using preliminarily generated simple object. On the assumption of mathematical principles of straight line we implemented mapping algorithm and for verification our experiment reconstructed the result.

  20. An integrated SNP mining and utilization (ISMU pipeline for next generation sequencing data.

    Directory of Open Access Journals (Sweden)

    Sarwar Azam

    Full Text Available Open source single nucleotide polymorphism (SNP discovery pipelines for next generation sequencing data commonly requires working knowledge of command line interface, massive computational resources and expertise which is a daunting task for biologists. Further, the SNP information generated may not be readily used for downstream processes such as genotyping. Hence, a comprehensive pipeline has been developed by integrating several open source next generation sequencing (NGS tools along with a graphical user interface called Integrated SNP Mining and Utilization (ISMU for SNP discovery and their utilization by developing genotyping assays. The pipeline features functionalities such as pre-processing of raw data, integration of open source alignment tools (Bowtie2, BWA, Maq, NovoAlign and SOAP2, SNP prediction (SAMtools/SOAPsnp/CNS2snp and CbCC methods and interfaces for developing genotyping assays. The pipeline outputs a list of high quality SNPs between all pairwise combinations of genotypes analyzed, in addition to the reference genome/sequence. Visualization tools (Tablet and Flapjack integrated into the pipeline enable inspection of the alignment and errors, if any. The pipeline also provides a confidence score or polymorphism information content value with flanking sequences for identified SNPs in standard format required for developing marker genotyping (KASP and Golden Gate assays. The pipeline enables users to process a range of NGS datasets such as whole genome re-sequencing, restriction site associated DNA sequencing and transcriptome sequencing data at a fast speed. The pipeline is very useful for plant genetics and breeding community with no computational expertise in order to discover SNPs and utilize in genomics, genetics and breeding studies. The pipeline has been parallelized to process huge datasets of next generation sequencing. It has been developed in Java language and is available at http://hpc.icrisat.cgiar.org/ISMU as a

  1. Silicon Photonics Integrated Circuits for 5th Generation mm-Wave Wireless Communications

    DEFF Research Database (Denmark)

    Rommel, Simon; Vegas Olmos, Juan José; Tafur Monroy, Idelfonso

    Hybrid photonic-wireless transmission schemes in the mm-wave frequency are promising candidates to enable the multi-gigabit per second data communications required from wireless and mobile networks of the 5th and future generations. Photonic integration may pave the way to practical applicability...... of such photonic-wireless hybrid links by reduction in complexity, size and – most importantly – cost....

  2. Western Wind and Solar Integration Study Phase 3A: Low Levels of Synchronous Generation

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Nicholas W. [GE Energy Management, Atlanta, GA (United States); Leonardi, Bruno [GE Energy Management, Atlanta, GA (United States); D' Aquila, Robert [GE Energy Management, Atlanta, GA (United States); Clark, Kara [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-11-17

    The stability of the North American electric power grids under conditions of high penetrations of wind and solar is a significant concern and possible impediment to reaching renewable energy goals. The 33% wind and solar annual energy penetration considered in this study results in substantial changes to the characteristics of the bulk power system. This includes different power flow patterns, different commitment and dispatch of existing synchronous generation, and different dynamic behavior from wind and solar generation. The Western Wind and Solar Integration Study (WWSIS), sponsored by the U.S. Department of Energy, is one of the largest regional solar and wind integration studies to date. In multiple phases, it has explored different aspects of the question: Can we integrate large amounts of wind and solar energy into the electric power system of the West? The work reported here focused on the impact of low levels of synchronous generation on the transient stability performance in one part of the region in which wind generation has displaced synchronous thermal generation under highly stressed, weak system conditions. It is essentially an extension of WWSIS-3. Transient stability, the ability of the power system to maintain synchronism among all elements following disturbances, is a major constraint on operations in many grids, including the western U.S. and Texas systems. These constraints primarily concern the performance of the large-scale bulk power system. But grid-wide stability concerns with high penetrations of wind and solar are still not thoroughly understood. This work focuses on 'traditional' fundamental frequency stability issues, such as maintaining synchronism, frequency, and voltage. The objectives of this study are to better understand the implications of low levels of synchronous generation and a weak grid on overall system performance by: 1) Investigating the Western Interconnection under conditions of both high renewable

  3. Thermoelectric Generators for the Integration into Automotive Exhaust Systems for Passenger Cars and Commercial Vehicles

    Science.gov (United States)

    Frobenius, Fabian; Gaiser, Gerd; Rusche, Ulrich; Weller, Bernd

    2016-03-01

    A special thermoelectric generator system design and the setup of a thermoelectric generator for the integration into the exhaust line of combustion engine-driven vehicles are described. A prototype setup for passenger cars and the effects on the measured power output are shown. Measurement results using this setup show the potential and the limitations of a setup based on thermoelectric modules commercially available today. In a second step, a short outline of the detailed mathematical modeling of the thermoelectric generator and simulation studies based on this model are presented. By this means, it can be shown by which measures an improvement of the system power output can be achieved—even if today's modules are used. Furthermore, simulation studies show how the exhaust gas conditions of diesel- and Otto-engines significantly affect the requirements on thermoelectric materials as well as the potential and the design of the thermoelectric generator. In a further step, the design and the setup of a thermoelectric generator for an application in a commercial vehicle are presented. This thermoelectric generator is designed to be integrated into the exhaust aftertreatment box of the vehicle. Experimental results with this setup are performed and presented. The results show that thermoelectric generators can become an interesting technology for exhaust waste heat recovery due to the fact that they comprise non-moving parts. However, the efficiency of the modules commercially available today is still far from what is required. Hence, modules made of new materials known from laboratory samples are urgently required. With regard to future CO2 regulations, a large market opportunity for modules with a high efficiency can be expected.

  4. Early generation pipeline girth welding practices and their implications for integrity management of North American pipelines

    Energy Technology Data Exchange (ETDEWEB)

    Amend, Bill [DNV Columbus, Inc., Yorba Linda, CA (United States)

    2010-07-01

    In response to the interest in ensuring the continued safe operation of vintage pipelines and the integrity management challenges related to those pipelines, PRCI sponsored in 2009 a project called {sup V}intage Girth Weld Defect Assessment - Comprehensive Study{sup .} Its objectives focused on girth welds made with the shielded metal arc welding (SMAW) process, particularly with regard to: review of approaches for evaluating the integrity of these welds; description of the typical characteristics and properties of SMAW vintage welds; determination of gaps in available information and technology that hinder effective integrity assessment and management of vintage girth welds. A very extensive literature review was performed as part of this project. Key findings include the following. The failure rate of early generation girth welds is low, especially when considering the rate of catastrophic failures. Pipeline girth welds are unlikely to fail unless subjected to axial strains that far exceed the strains related to internal pressure alone.

  5. Integral equation for electrostatic waves generated by a point source in a spatially homogeneous magnetized plasma

    Energy Technology Data Exchange (ETDEWEB)

    Podesta, John J. [Space Science Institute, Boulder, Colorado 80301 (United States)

    2012-08-15

    The electric field generated by a time varying point charge in a three-dimensional, unbounded, spatially homogeneous plasma with a uniform background magnetic field and a uniform (static) flow velocity is studied in the electrostatic approximation which is often valid in the near field. For plasmas characterized by Maxwell distribution functions with isotropic temperatures, the linearized Vlasov-Poisson equations may be formulated in terms of an equivalent integral equation in the time domain. The kernel of the integral equation has a relatively simple mathematical form consisting of elementary functions such as exponential and trigonometric functions (sines and cosines), and contains no infinite sums of Bessel functions. Consequently, the integral equation is amenable to numerical solutions and may be useful for the study of the impulse response of magnetized plasmas and, more generally, the response to arbitrary waveforms.

  6. Integrated Computational Materials Engineering (ICME) for Third Generation Advanced High-Strength Steel Development

    Energy Technology Data Exchange (ETDEWEB)

    Savic, Vesna; Hector, Louis G.; Ezzat, Hesham; Sachdev, Anil K.; Quinn, James; Krupitzer, Ronald; Sun, Xin

    2015-06-01

    This paper presents an overview of a four-year project focused on development of an integrated computational materials engineering (ICME) toolset for third generation advanced high-strength steels (3GAHSS). Following a brief look at ICME as an emerging discipline within the Materials Genome Initiative, technical tasks in the ICME project will be discussed. Specific aims of the individual tasks are multi-scale, microstructure-based material model development using state-of-the-art computational and experimental techniques, forming, toolset assembly, design optimization, integration and technical cost modeling. The integrated approach is initially illustrated using a 980 grade transformation induced plasticity (TRIP) steel, subject to a two-step quenching and partitioning (Q&P) heat treatment, as an example.

  7. Equivalent Method of Integrated Power Generation System of Wind, Photovoltaic and Energy Storage in Power Flow Calculation and Transient Simulation

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    The integrated power generation system of wind, photovoltaic (PV) and energy storage is composed of several wind turbines, PV units and energy storage units. The detailed model of integrated generation is not suitable for the large-scale powe.r system simulation because of the model's complexity and long computation time. An equivalent method for power flow calculation and transient simulation of the integrated generation system is proposed based on actual projects, so as to establish the foundation of such integrated system simulation and analysis.

  8. [Integrity].

    Science.gov (United States)

    Gómez Rodríguez, Rafael Ángel

    2014-01-01

    To say that someone possesses integrity is to claim that that person is almost predictable about responses to specific situations, that he or she can prudentially judge and to act correctly. There is a closed interrelationship between integrity and autonomy, and the autonomy rests on the deeper moral claim of all humans to integrity of the person. Integrity has two senses of significance for medical ethic: one sense refers to the integrity of the person in the bodily, psychosocial and intellectual elements; and in the second sense, the integrity is the virtue. Another facet of integrity of the person is la integrity of values we cherish and espouse. The physician must be a person of integrity if the integrity of the patient is to be safeguarded. The autonomy has reduced the violations in the past, but the character and virtues of the physician are the ultimate safeguard of autonomy of patient. A field very important in medicine is the scientific research. It is the character of the investigator that determines the moral quality of research. The problem arises when legitimate self-interests are replaced by selfish, particularly when human subjects are involved. The final safeguard of moral quality of research is the character and conscience of the investigator. Teaching must be relevant in the scientific field, but the most effective way to teach virtue ethics is through the example of the a respected scientist.

  9. Determinants of patient loyalty to healthcare providers: An integrative review.

    Science.gov (United States)

    Zhou, Wei-Jiao; Wan, Qiao-Qin; Liu, Cong-Ying; Feng, Xiao-Lin; Shang, Shao-Mei

    2017-08-01

    Patient loyalty is key to business success for healthcare providers and also for patient health outcomes. This study aims to identify determinants influencing patient loyalty to healthcare providers and propose an integrative conceptual model of the influencing factors. PubMed, CINAHL, OVID, ProQuest and Elsevier Science Direct databases were searched. Publications about determinants of patient loyalty to health providers were screened, and 13 articles were included. Date of publication, location of the research, sample details, objectives and findings/conclusions were extracted for 13 articles. Thirteen studies explored eight determinants: satisfaction, quality, value, hospital brand image, trust, commitment, organizational citizenship behavior and customer complaints. The integrated conceptual model comprising all the determinants demonstrated the significant positive direct impact of quality on satisfaction and value, satisfaction on trust and commitment, trust on commitment and loyalty, and brand image on quality and loyalty. This review identifies and models the determinants of patient loyalty to healthcare providers. Further studies are needed to explore the influence of trust, commitment, and switching barriers on patient loyalty.

  10. The educational integration of second generation southern Italian migrants to the north

    Directory of Open Access Journals (Sweden)

    Gabriele Ballarino

    2015-11-01

    Full Text Available Background: After WW2 Italy experienced a huge internal migration from the south to the northern Italian regions. More than two million individuals moved up north, and the majority of them settled down permanently. How were southern internal migrants integrated into northern Italian society? Despite the theoretical and substantial relevance of the topic, there has been little systematic research on it. Objective: This work studies the assimilation of this migration flux from a long-term perspective, comparing the school outcomes of the children of southern migrants to those of both northerners' children and children of southern families who did not move. Methods: To this aim, logit models of three different school transitions are applied to data from the Italian Longitudinal Household Survey (ILHS, a retrospective panel survey that includes detailed life-course information on a representative sample of roughly 11,000 Italians. Results: There is no difference between the educational performance of both generation 2 and the mix generation and that of the northerners. However, strong and significant disadvantages were found with regard to generation 1.5, due to the disruption in individual school experience caused by the migration itself. Conclusions: The Italian educational system played an important role in facilitating the integration of the second generation of Southern immigrants, but it was less able to assimilate those who had already begun their studies in the south before following their parents to the north.

  11. Faraday Waves-Based Integrated Ultrasonic Micro-Droplet Generator and Applications

    Directory of Open Access Journals (Sweden)

    Chen S. Tsai

    2017-02-01

    Full Text Available An in-depth review on a new ultrasonic micro-droplet generator which utilizes megahertz (MHz Faraday waves excited by silicon-based multiple Fourier horn ultrasonic nozzles (MFHUNs and its potential applications is presented. The new droplet generator has demonstrated capability for producing micro droplets of controllable size and size distribution and desirable throughput at very low electrical drive power. For comparison, the serious deficiencies of current commercial droplet generators (nebulizers and the other ultrasonic droplet generators explored in recent years are first discussed. The architecture, working principle, simulation, and design of the multiple Fourier horns (MFH in resonance aimed at the amplified longitudinal vibration amplitude on the end face of nozzle tip, and the fabrication and characterization of the nozzles are then described in detail. Subsequently, a linear theory on the temporal instability of Faraday waves on a liquid layer resting on the planar end face of the MFHUN and the detailed experimental verifications are presented. The linear theory serves to elucidate the dynamics of droplet ejection from the free liquid surface and predict the vibration amplitude onset threshold for droplet ejection and the droplet diameters. A battery-run pocket-size clogging-free integrated micro droplet generator realized using the MFHUN is then described. The subsequent report on the successful nebulization of a variety of commercial pulmonary medicines against common diseases and on the experimental antidote solutions to cyanide poisoning using the new droplet generator serves to support its imminent application to inhalation drug delivery.

  12. Prototype testing and analysis of a novel internal combustion linear generator integrated power system

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Zhaoping; Chang, Siqin [School of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing 210094 (China)

    2010-04-15

    A novel four-stroke free-piston engine equipped with a linear electric generator (namely internal combustion linear generator integrated power system) is proposed in this paper to achieve efficient energy conversion from fuel to electricity. Unique features of the novel power system are presented and their effects on the continuous running are discussed, along with potential advantages and disadvantages compared to conventional engines. A single cylinder, gasoline and spark ignition prototype is fabricated with reference to the geometric and control parameters of an existing conventional four-stroke engine. Stable running of the prototype is realized, and a 2.2 kW average output power with the generating efficiency of 32% has been obtained up to now. The feasibility and performance of the proposed design are verified. Detailed testing results from the continuous running prototype are analyzed in this paper for giving insight into the performance and dynamic behaviors of the novel power system. (author)

  13. Geothermal electricity generation and desalination: an integrated process design to conserve latent heat with operational improvements

    KAUST Repository

    Missimer, Thomas M.

    2016-02-05

    A new process combination is proposed to link geothermal electricity generation with desalination. The concept involves maximizing the utilization of harvested latent heat by passing the turbine exhaust steam into a multiple effect distillation system and then into an adsorption desalination system. Processes are fully integrated to produce electricity, desalted water for consumer consumption, and make-up water for the geothermal extraction system. Further improvements in operational efficiency are achieved by adding a seawater reverse osmosis system to the site to utilize some of the generated electricity and using on-site aquifer storage and recovery to maximize water production with tailoring of seasonal capacity requirements and to meet facility maintenance requirements. The concept proposed conserves geothermally harvested latent heat and maximizes the economics of geothermal energy development. Development of a fully renewable energy electric generation-desalination-aquifer storage campus is introduced within the framework of geothermal energy development. © 2016 The Author(s). Published by Taylor & Francis

  14. Integrating Spirituality as a Key Component of Patient Care

    Directory of Open Access Journals (Sweden)

    Suzette Brémault-Phillips

    2015-04-01

    Full Text Available Patient care frequently focuses on physical aspects of disease management, with variable attention given to spiritual needs. And yet, patients indicate that spiritual suffering adds to distress associated with illness. Spirituality, broadly defined as that which gives meaning and purpose to a person’s life and connectedness to the significant or sacred, often becomes a central issue for patients. Growing evidence demonstrates that spirituality is important in patient care. Yet healthcare professionals (HCPs do not always feel prepared to engage with patients about spiritual issues. In this project, HCPs attended an educational session focused on using the FICA Spiritual History Tool to integrate spirituality into patient care. Later, they incorporated the tool when caring for patients participating in the study. This research (1 explored the value of including spiritual history taking in clinical practice; (2 identified facilitators and barriers to incorporating spirituality into person-centred care; and (3 determined ways in which HCPs can effectively utilize spiritual history taking. Data were collected using focus groups and chart reviews. Findings indicate positive impacts at organizational, clinical/unit, professional/personal and patient levels when HCPs include spirituality in patient care. Recommendations are offered.

  15. Analysis of T-DNA integration and generative segregation in transgenic winter triticale (x Triticosecale Wittmack

    Directory of Open Access Journals (Sweden)

    Hensel Goetz

    2012-09-01

    Full Text Available Abstract Background While the genetic transformation of the major cereal crops has become relatively routine, to date only a few reports were published on transgenic triticale, and robust data on T-DNA integration and segregation have not been available in this species. Results Here, we present a comprehensive analysis of stable transgenic winter triticale cv. Bogo carrying the selectable marker gene HYGROMYCIN PHOSPHOTRANSFERASE (HPT and a synthetic green fluorescent protein gene (gfp. Progeny of four independent transgenic plants were comprehensively investigated with regard to the number of integrated T-DNA copies, the number of plant genomic integration loci, the integrity and functionality of individual T-DNA copies, as well as the segregation of transgenes in T1 and T2 generations, which also enabled us to identify homozygous transgenic lines. The truncation of some integrated T-DNAs at their left end along with the occurrence of independent segregation of multiple T-DNAs unintendedly resulted in a single-copy segregant that is selectable marker-free and homozygous for the gfp gene. The heritable expression of gfp driven by the maize UBI-1 promoter was demonstrated by confocal laser scanning microscopy. Conclusions The used transformation method is a valuable tool for the genetic engineering of triticale. Here we show that comprehensive molecular analyses are required for the correct interpretation of phenotypic data collected from the transgenic plants.

  16. Generation of renewable energy integrated with food production in Brazil GERIPA project

    Energy Technology Data Exchange (ETDEWEB)

    Lombardi, Geraldo; Corsini, Romeu [Universidade de Sao Paulo (USP), Sao Carlos, SP (Brazil). Escola de Engenharia]. E-mails: lombardi@sc.usp.br; corsiniromeu@ig.com.br; Ramos, Pedro A.R. [Instituto Superior Politecnico Jose Antonio Echeverria (CUJAE), Ciudad de La Habana (Cuba). Facultad Ingenieria Mecanica]. E-mail: pedro@economia.cujae.edu.cu

    2008-07-01

    This paper reports on a study of the economic viability of a Socio-Agroindustrial Ecological Organism for the Generation of Renewable Energy Integrated with Food Production-GERIPA Project. With a minimum production of 125,000 liters of alcohol per day, it has low energy costs in both cogeneration of electricity and alcohol, and in diversified food production with a pay back time of 5.66 years due exclusively to the integrated procedure. The GERIPA meets the basic needs of a city with a population of 53,000, and is characterized as an autonomous development center, with social and environmental high quality, based on the Kyoto Protocol and the premises of Sustainable Development. Attesting the importance of the integration concept, two calculation models are presented: 1- Basic Model, to which ethanol has credited all investments and inherent expenses to its production, as usual; and 2- Integrated Model, where the integration concept implies the co-responsibility of its products in proportion to the total income, basis of the GERIPA economical success. The cost of ethanol production in this model is 38% lower than that of actual alcohol mills-0.640 R$/L. (1 US$=R$2.01-12/2007). (author)

  17. Multi Sensor Data Integration for AN Accurate 3d Model Generation

    Science.gov (United States)

    Chhatkuli, S.; Satoh, T.; Tachibana, K.

    2015-05-01

    The aim of this paper is to introduce a novel technique of data integration between two different data sets, i.e. laser scanned RGB point cloud and oblique imageries derived 3D model, to create a 3D model with more details and better accuracy. In general, aerial imageries are used to create a 3D city model. Aerial imageries produce an overall decent 3D city models and generally suit to generate 3D model of building roof and some non-complex terrain. However, the automatically generated 3D model, from aerial imageries, generally suffers from the lack of accuracy in deriving the 3D model of road under the bridges, details under tree canopy, isolated trees, etc. Moreover, the automatically generated 3D model from aerial imageries also suffers from undulated road surfaces, non-conforming building shapes, loss of minute details like street furniture, etc. in many cases. On the other hand, laser scanned data and images taken from mobile vehicle platform can produce more detailed 3D road model, street furniture model, 3D model of details under bridge, etc. However, laser scanned data and images from mobile vehicle are not suitable to acquire detailed 3D model of tall buildings, roof tops, and so forth. Our proposed approach to integrate multi sensor data compensated each other's weakness and helped to create a very detailed 3D model with better accuracy. Moreover, the additional details like isolated trees, street furniture, etc. which were missing in the original 3D model derived from aerial imageries could also be integrated in the final model automatically. During the process, the noise in the laser scanned data for example people, vehicles etc. on the road were also automatically removed. Hence, even though the two dataset were acquired in different time period the integrated data set or the final 3D model was generally noise free and without unnecessary details.

  18. Patient involvement in the safety of care: an integrative review

    Directory of Open Access Journals (Sweden)

    Thaynara de Oliveira Silva

    2016-06-01

    Full Text Available The aim of this integrative review was to survey the strategies adopted by health institutions that involve patients in care as a barrier to prevent incidents. A search was conducted in MEDLINE, LILACS, CINAHL and PubMed databases using the descriptors ‘patient safety’, ‘iatrogenic’, ‘medical error’ and ‘involvement’. The review included studies in full text published between 2003 and March 2016 in English, Spanish or Portuguese. It was found that the effective communication and the development of patients’ autonomy are the most advocated strategies. The level of evidence of studies was limited to four and six. The assessment or description of institutional practices involving patients in their safety emerged as a gap in scientific knowledge. The impact of this review is to demonstrate the need for randomized studies to identify effective interventions, directing health institutions towards change in the organizational culture, focusing on safety and patient-centered care.

  19. Empirical Analysis of the Variability of Wind Generation in India: Implications for Grid Integration

    Energy Technology Data Exchange (ETDEWEB)

    Phadke, Amol; Abhyankar, NIkit; Rao, Poorvi

    2014-06-17

    We analyze variability in load and wind generation in India to assess its implications for grid integration of large scale wind projects using actual wind generation and load data from two states in India, Karnataka and Tamil Nadu. We compare the largest variations in load and net load (load ?wind, i.e., load after integrating wind) that the generation fleet has to meet. In Tamil Nadu, where wind capacity is about 53percent of the peak demand, we find that the additional variation added due to wind over the current variation in load is modest; if wind penetration reaches 15percent and 30percent by energy, the additional hourly variation is less than 0.5percent and 4.5percent of the peak demand respectively for 99percent of the time. For wind penetration of 15percent by energy, Tamil Nadu system is found to be capable of meeting the additional ramping requirement for 98.8percent of the time. Potential higher uncertainty in net load compared to load is found to have limited impact on ramping capability requirements of the system if coal plants can me ramped down to 50percent of their capacity. Load and wind aggregation in Tamil Nadu and Karnataka is found to lower the variation by at least 20percent indicating the benefits geographic diversification. These findings suggest modest additional flexible capacity requirements and costs for absorbing variation in wind power and indicate that the potential capacity support (if wind does not generate enough during peak periods) may be the issue that has more bearing on the economics of integrating wind

  20. Design and Control of Integrated Systems for Hydrogen Production and Power Generation

    Science.gov (United States)

    Georgis, Dimitrios

    Growing concerns on CO2 emissions have led to the development of highly efficient power plants. Options for increased energy efficiencies include alternative energy conversion pathways, energy integration and process intensification. Solid oxide fuel cells (SOFC) constitute a promising alternative for power generation since they convert the chemical energy electrochemically directly to electricity. Their high operating temperature shows potential for energy integration with energy intensive units (e.g. steam reforming reactors). Although energy integration is an essential tool for increased efficiencies, it leads to highly complex process schemes with rich dynamic behavior, which are challenging to control. Furthermore, the use of process intensification for increased energy efficiency imposes an additional control challenge. This dissertation identifies and proposes solutions on design, operational and control challenges of integrated systems for hydrogen production and power generation. Initially, a study on energy integrated SOFC systems is presented. Design alternatives are identified, control strategies are proposed for each alternative and their validity is evaluated under different operational scenarios. The operational range of the proposed control strategies is also analyzed. Next, thermal management of water gas shift membrane reactors, which are a typical application of process intensification, is considered. Design and operational objectives are identified and a control strategy is proposed employing advanced control algorithms. The performance of the proposed control strategy is evaluated and compared with classical control strategies. Finally SOFC systems for combined heat and power applications are considered. Multiple recycle loops are placed to increase design flexibility. Different operational objectives are identified and a nonlinear optimization problem is formulated. Optimal designs are obtained and their features are discussed and compared

  1. Integrated health care for patients with motor neurone disease.

    Science.gov (United States)

    Brewah, Helen

    This article presents the findings from a study trip to Kaiser Permanente (KP), a private healthcare provider in the USA. The aim of the trip was to understand how healthcare integration is managed in KP and how this might help patients in the UK with motor neurone disease (MND). This article makes reference to the American and British healthcare systems, identifying the simple differences between health economies, and their impact on health care, with specific reference to MND. The trip was undertaken as part of the author's ongoing work on how patients with MND rate services delivered by the multidisciplinary team (MDT) in the UK. The author's community matron role involves caring for patients with long-term conditions (LTCs) including long-term neurological conditions (LTNCs). In executing this role and in service delivery to patients with LTNCs, specifically MND, the author noticed a lack of robust integration, highlighting the need to consider and address the various contributory factors. This article presents a literature review and analyses the role of the MDT including specialist neurological professionals in executing duties and in delivering healthcare services to patients diagnosed with MND. The implications for practice are also presented along with areas for practice development.

  2. Evidence for cognitive vestibular integration impairment in idiopathic scoliosis patients

    Directory of Open Access Journals (Sweden)

    Mercier Pierre

    2009-08-01

    Full Text Available Abstract Background Adolescent idiopathic scoliosis is characterized by a three-dimensional deviation of the vertebral column and its etiopathogenesis is unknown. Various factors cause idiopathic scoliosis, and among these a prominent role has been attributed to the vestibular system. While the deficits in sensorimotor transformations have been documented in idiopathic scoliosis patients, little attention has been devoted to their capacity to integrate vestibular information for cognitive processing for space perception. Seated idiopathic scoliosis patients and control subjects experienced rotations of different directions and amplitudes in the dark and produced saccades that would reproduce their perceived spatial characteristics of the rotations (vestibular condition. We also controlled for possible alteration of the oculomotor and vestibular systems by measuring the subject's accuracy in producing saccades towards memorized peripheral targets in absence of body rotation and the gain of their vestibulo-ocular reflex. Results Compared to healthy controls, the idiopathic scoliosis patients underestimated the amplitude of their rotations. Moreover, the results revealed that idiopathic scoliosis patients produced accurate saccades to memorized peripheral targets in absence of body rotation and that their vestibulo-ocular reflex gain did not differ from that of control participants. Conclusion Overall, results of the present study demonstrate that idiopathic scoliosis patients have an alteration in cognitive integration of vestibular signals. It is possible that severe spine deformity developed partly due to impaired vestibular information travelling from the cerebellum to the vestibular cortical network or alteration in the cortical mechanisms processing the vestibular signals.

  3. Audiovisual integration of speech in a patient with Broca's Aphasia.

    Science.gov (United States)

    Andersen, Tobias S; Starrfelt, Randi

    2015-01-01

    Lesions to Broca's area cause aphasia characterized by a severe impairment of the ability to speak, with comparatively intact speech perception. However, some studies have found effects on speech perception under adverse listening conditions, indicating that Broca's area is also involved in speech perception. While these studies have focused on auditory speech perception other studies have shown that Broca's area is activated by visual speech perception. Furthermore, one preliminary report found that a patient with Broca's aphasia did not experience the McGurk illusion suggesting that an intact Broca's area is necessary for audiovisual integration of speech. Here we describe a patient with Broca's aphasia who experienced the McGurk illusion. This indicates that an intact Broca's area is not necessary for audiovisual integration of speech. The McGurk illusions this patient experienced were atypical, which could be due to Broca's area having a more subtle role in audiovisual integration of speech. The McGurk illusions of a control subject with Wernicke's aphasia were, however, also atypical. This indicates that the atypical McGurk illusions were due to deficits in speech processing that are not specific to Broca's aphasia.

  4. pfSNP: An integrated potentially functional SNP resource that facilitates hypotheses generation through knowledge syntheses.

    Science.gov (United States)

    Wang, Jingbo; Ronaghi, Mostafa; Chong, Samuel S; Lee, Caroline G L

    2011-01-01

    Currently, >14,000,000 single nucleotide polymorphisms (SNPs) are reported. Identifying phenotype-affecting SNPs among these many SNPs pose significant challenges. Although several Web resources are available that can inform about the functionality of SNPs, these resources are mainly annotation databases and are not very comprehensive. In this article, we present a comprehensive, well-annotated, integrated pfSNP (potentially functional SNPs) Web resource (http://pfs.nus.edu.sg/), which is aimed to facilitate better hypothesis generation through knowledge syntheses mediated by better data integration and a user-friendly Web interface. pfSNP integrates >40 different algorithms/resources to interrogate >14,000,000 SNPs from the dbSNP database for SNPs of potential functional significance based on previous published reports, inferred potential functionality from genetic approaches as well as predicted potential functionality from sequence motifs. Its query interface has the user-friendly "auto-complete, prompt-as-you-type" feature and is highly customizable, facilitating different combination of queries using Boolean-logic. Additionally, to facilitate better understanding of the results and aid in hypotheses generation, gene/pathway-level information with text clouds highlighting enriched tissues/pathways as well as detailed-related information are also provided on the results page. Hence, the pfSNP resource will be of great interest to scientists focusing on association studies as well as those interested to experimentally address the functionality of SNPs.

  5. GABA regulates synaptic integration of newly generated neurons in the adult brain

    Science.gov (United States)

    Ge, Shaoyu; Goh, Eyleen L. K.; Sailor, Kurt A.; Kitabatake, Yasuji; Ming, Guo-Li; Song, Hongjun

    2006-02-01

    Adult neurogenesis, the birth and integration of new neurons from adult neural stem cells, is a striking form of structural plasticity and highlights the regenerative capacity of the adult mammalian brain. Accumulating evidence suggests that neuronal activity regulates adult neurogenesis and that new neurons contribute to specific brain functions. The mechanism that regulates the integration of newly generated neurons into the pre-existing functional circuitry in the adult brain is unknown. Here we show that newborn granule cells in the dentate gyrus of the adult hippocampus are tonically activated by ambient GABA (γ-aminobutyric acid) before being sequentially innervated by GABA- and glutamate-mediated synaptic inputs. GABA, the major inhibitory neurotransmitter in the adult brain, initially exerts an excitatory action on newborn neurons owing to their high cytoplasmic chloride ion content. Conversion of GABA-induced depolarization (excitation) into hyperpolarization (inhibition) in newborn neurons leads to marked defects in their synapse formation and dendritic development in vivo. Our study identifies an essential role for GABA in the synaptic integration of newly generated neurons in the adult brain, and suggests an unexpected mechanism for activity-dependent regulation of adult neurogenesis, in which newborn neurons may sense neuronal network activity through tonic and phasic GABA activation.

  6. Fuzzy Logic Controller Based Distributed Generation Integration Strategy for Stochastic Performance Improvement

    Directory of Open Access Journals (Sweden)

    Jagdish Prasad Sharma

    2016-01-01

    Full Text Available In the restructured environment, distributed generation (DG is considered as a very promising option due to a high initial capital cost of conventional plants, environmental concerns, and power shortage. Apart from the above, distributed generation (DG has also abilities to improve performance of feeder. Most of the distribution feeders have radial structure, which compel to observe the impact of distributed generations on feeder performance, having different characteristics and composition of time varying static ZIP load models. Two fuzzy-based expert system is proposed for selecting and ranking the most appropriated periods to an integration of distributed generations with a feeder. Madami type fuzzy logic controller was developed for sizing of distributed generation, whereas Sugeno type fuzzy logic controller was developed for the DG location. Input parameters for Madami fuzzy logic controller are substation reserve capacity, feeder power loss to load ratio, voltage unbalance, and apparent power imbalances. DG output, survivability index, and node distance from substation are chosen as input to Sugeno type fuzzy logic controller. The stochastic performance of proposed fuzzy expert systems was evaluated on a modified IEEE 37 node test feeder with 15 minutes characteristics time interval varying static ZIP load models.

  7. Impaired integration of disambiguating evidence in delusional schizophrenia patients.

    Science.gov (United States)

    Sanford, N; Veckenstedt, R; Moritz, S; Balzan, R P; Woodward, T S

    2014-10-01

    It has been previously demonstrated that a cognitive bias against disconfirmatory evidence (BADE) is associated with delusions. However, small samples of delusional patients, reliance on difference scores and choice of comparison groups may have hampered the reliability of these results. In the present study we aimed to improve on this methodology with a recent version of the BADE task, and compare larger groups of schizophrenia patients with/without delusions to obsessive-compulsive disorder (OCD) patients, a population with persistent and possibly bizarre beliefs without psychosis. A component analysis was used to identify cognitive operations underlying the BADE task, and how they differ across four groups of participants: (1) high-delusional schizophrenia, (2) low-delusional schizophrenia, (3) OCD patients and (4) non-psychiatric controls. As in past studies, two components emerged and were labelled 'evidence integration' (the degree to which disambiguating information has been integrated) and 'conservatism' (reduced willingness to provide high plausibility ratings when justified), and only evidence integration differed between severely delusional patients and the other groups, reflecting delusional subjects giving higher ratings for disconfirmed interpretations and lower ratings for confirmed interpretations. These data support the finding that a reduced willingness to adjust beliefs when confronted with disconfirming evidence may be a cognitive underpinning of delusions specifically, rather than obsessive beliefs or other aspects of psychosis such as hallucinations, and illustrates a cognitive process that may underlie maintenance of delusions in the face of counter-evidence. This supports the possibility of the BADE operation being a useful target in cognitive-based therapies for delusions.

  8. Integration of direct carbon and hydrogen fuel cells for highly efficient power generation from hydrocarbon fuels

    Energy Technology Data Exchange (ETDEWEB)

    Muradov, Nazim; Choi, Pyoungho; Smith, Franklyn; Bokerman, Gary [Florida Solar Energy Center, University of Central Florida, 1679 Clearlake Road, Cocoa, FL 32922-5703 (United States)

    2010-02-15

    In view of impending depletion of hydrocarbon fuel resources and their negative environmental impact, it is imperative to significantly increase the energy conversion efficiency of hydrocarbon-based power generation systems. The combination of a hydrocarbon decomposition reactor with a direct carbon and hydrogen fuel cells (FC) as a means for a significant increase in chemical-to-electrical energy conversion efficiency is discussed in this paper. The data on development and operation of a thermocatalytic hydrocarbon decomposition reactor and its coupling with a proton exchange membrane FC are presented. The analysis of the integrated power generating system including a hydrocarbon decomposition reactor, direct carbon and hydrogen FC using natural gas and propane as fuels is conducted. It was estimated that overall chemical-to-electrical energy conversion efficiency of the integrated system varied in the range of 49.4-82.5%, depending on the type of fuel and FC used, and CO{sub 2} emission per kW{sub el}h produced is less than half of that from conventional power generation sources. (author)

  9. The Next Generation of Dietitians: Implementing Dietetics Education and Practice in Integrative Medicine.

    Science.gov (United States)

    Wagner, Leigh E; Evans, Randall G; Noland, Diana; Barkley, Rachel; Sullivan, Debra K; Drisko, Jeanne

    2015-01-01

    Integrative medicine is a quickly expanding field of health care that emphasizes nutrition as a key component. Dietitians and nutritionists have an opportunity to meet workforce demands by practicing dietetics and integrative medicine (DIM). The purpose of this article is to describe a DIM education program and practicum. We report the results of an interprofessional nutrition education and practicum program between the University of Kansas Medical Center (KUMC) Department of Dietetics and Nutrition and KU Integrative Medicine. This partnered program provides training that builds on the strong foundation of the Nutrition Care Process and adds graduate-level educational and practicum experiences in foundational integrative medicine knowledge, including nutritional approaches from a systems biology perspective, nutrigenomics, and biochemistry as the core knowledge to understand the root cause of a chronic disorder and to choose appropriate nutritional tools for interventions. This interprofessional KUMC program provides a dietetic internship, master's degree, and graduate certificate in DIM and fulfills a need for dietitians and nutritionists who seek careers practicing in an integrative medicine setting. The program fulfills expanding workforce needs to provide quality health care for patients with chronic illnesses.

  10. Atypical crossmodal emotional integration in patients with gliomas.

    Science.gov (United States)

    Luherne-du Boullay, Viviane; Plaza, Monique; Perrault, Annabelle; Capelle, Laurent; Chaby, Laurence

    2014-11-01

    The relevance of emotional perception in interpersonal relationships and social cognition has been well documented. Although brain diseases might impair emotional processing, studies concerning emotional recognition in patients with brain tumours are relatively rare. The aim of this study was to explore emotional recognition in patients with gliomas in three conditions (visual, auditory and crossmodal) and to analyse how tumour-related variables (notably, tumour localisation) and patient-related variables influence emotion recognition. Twenty six patients with gliomas and 26 matched healthy controls were instructed to identify 5 basic emotions and a neutral expression, which were displayed through visual, auditory and crossmodal stimuli. Relative to the controls, recognition was weakly impaired in the patient group under both visual and auditory conditions, but the performances were comparable in the crossmodal condition. Additional analyses using the 'race model' suggest differences in multisensory emotional integration abilities across the groups, which were potentially correlated with the executive disorders observed in the patients. These observations support the view of compensatory mechanisms in the case of gliomas that might preserve the quality of life and help maintain the normal social and professional lives often observed in these patients. Copyright © 2014 Elsevier Inc. All rights reserved.

  11. Impact of sensory integration training on balance among stroke patients: sensory integration training on balance among stroke patients

    Directory of Open Access Journals (Sweden)

    Jang Sang Hun

    2016-08-01

    Full Text Available This study attempts to investigate the impact that the sensory integration training has on the recovery of balance among patients with stroke by examining the muscle activity and limit of stability (LOS. A total of 28 subjects participated. The subjects were randomly allocated by the computer program to one of two groups: control (CON group (n=15, sensory integration training (SIT group (n=13. The research subjects received intervention five days a week for a total of four weeks. The CON group additionally received 30-minute general balance training, while the SIT group additionally received 30-minute sensory integration training. In the muscle activity, the improvement of Erector spinae (ES and Gluteus medius (GM was more significant in the SIT group than in the CON group. In the LOS, the improvement of affected side and forward side was significantly higher in the SIT group compared to the CON group. Sensory integration training can improve balance ability of patients with stroke by increasing muscle activity of stance limb muscles such as GM and trunk extensor such as ES along with enhancement of the limit of stability.

  12. Integrating patient satisfaction into performance measurement to meet improvement challenges.

    Science.gov (United States)

    Smith, J E; Fisher, D L; Endorf-Olson, J J

    2000-05-01

    A Value Compass has been proposed to guide health care data collection. The "compass corners" represent the four types of data needed to meet health care customer expectations: appropriate clinical outcomes, improved functional status, patient satisfaction, and appropriate costs. Collection of all four types of data is necessary to select processes in need of improvement, guide improvement teams, and monitor the success of improvement efforts. INTEGRATED DATA AT BRYANLGH: BryanLGH Medical Center in Lincoln, Nebraska, has adopted multiple performance measurement systems to collect clinical outcome, financial, and patient satisfaction data into integrated databases. Data integration allows quality professionals at BryanLGH to identify quality issues from multiple perspectives and track the interrelated effects of improvement efforts. A CASE EXAMPLE: Data from the fourth quarter of 1997 indicated the need to improve processes related to cesarean section (C-section) deliveries. An interdisciplinary team was formed, which focused on educating nurses, physicians, and the community about labor support measures. Physicians were given their own rates of C-section deliveries. The C-section rate decreased from 27% to 19%, but per-case cost increased. PickerPLUS+ results indicated that BryanLGH obstetric patients reported fewer problems with receiving information than the Picker norm, but they reported more problems with the involvement of family members and friends. The data collected so far have indicated a decrease in the C-section rate and a need to continue to work on cost and psychosocial issues. A complete analysis of results was facilitated by integrated performance management systems. Successes have been easily tracked over time, and the need for further work on related processes has been clearly identified.

  13. A model for integrated analysis of generation capacity expansion and financial planning

    Energy Technology Data Exchange (ETDEWEB)

    Majumdar, S. [Indian Inst. of Management, Ahmedabad (India). Public Systems Group; Chattopadhyay, D. [Univ. of Canterbury, Christchurch (New Zealand). Dept. of Management

    1999-05-01

    This paper discusses the need for an integrated analysis of investment and financing decisions in the context of electricity generation capacity addition planning. The traditional mathematical programming model for investment planning and its potential enhancement to encompass financing decisions in a unified framework have been discussed. The integrated investment-finance model for power system is formulated. The model is implemented for a well-known investment planning case study and the various investment-financing interactions have been discussed. The results indicate that the interaction of financing and investment decisions could be very significant and needs to be accounted for capacity planning optimization exercises. This is particularly relevant for utilities in a competitive environment.

  14. Image Generation Using Bidirectional Integral Features for Face Recognition with a Single Sample per Person.

    Directory of Open Access Journals (Sweden)

    Yonggeol Lee

    Full Text Available In face recognition, most appearance-based methods require several images of each person to construct the feature space for recognition. However, in the real world it is difficult to collect multiple images per person, and in many cases there is only a single sample per person (SSPP. In this paper, we propose a method to generate new images with various illuminations from a single image taken under frontal illumination. Motivated by the integral image, which was developed for face detection, we extract the bidirectional integral feature (BIF to obtain the characteristics of the illumination condition at the time of the picture being taken. The experimental results for various face databases show that the proposed method results in improved recognition performance under illumination variation.

  15. Analyzing Web 2.0 Integration with Next Generation Networks for Services Rendering

    CERN Document Server

    Lakhtaria, Kamaljit I

    2010-01-01

    The Next Generation Networks (NGN) aims to integrate for IP-based telecom infrastructures and provide most advance & high speed emerging value added services. NGN capable to provide higher innovative services, these services will able to integrate communication and Web service into a single platform. IP Multimedia Subsystem, a NGN leading technology, enables a variety of NGN-compliant communications services to interoperate while being accessed through different kinds of access networks, preferably broadband. IMS–NGN services essential by both consumer and corporate users are by now used to access services, even communications services through the web and web-based communities and social networks, It is key for success of IMS-based services to be provided with efficient web access, so users can benefit from those new services by using web-based applications and user interfaces, not only NGN-IMS User Equipments and SIP protocol. Many Service are under planning which provided only under convergence of ...

  16. Image Generation Using Bidirectional Integral Features for Face Recognition with a Single Sample per Person

    Science.gov (United States)

    Lee, Yonggeol; Lee, Minsik; Choi, Sang-Il

    2015-01-01

    In face recognition, most appearance-based methods require several images of each person to construct the feature space for recognition. However, in the real world it is difficult to collect multiple images per person, and in many cases there is only a single sample per person (SSPP). In this paper, we propose a method to generate new images with various illuminations from a single image taken under frontal illumination. Motivated by the integral image, which was developed for face detection, we extract the bidirectional integral feature (BIF) to obtain the characteristics of the illumination condition at the time of the picture being taken. The experimental results for various face databases show that the proposed method results in improved recognition performance under illumination variation. PMID:26414018

  17. Applying Model Checking to Generate Model-Based Integration Tests from Choreography Models

    Science.gov (United States)

    Wieczorek, Sebastian; Kozyura, Vitaly; Roth, Andreas; Leuschel, Michael; Bendisposto, Jens; Plagge, Daniel; Schieferdecker, Ina

    Choreography models describe the communication protocols between services. Testing of service choreographies is an important task for the quality assurance of service-based systems as used e.g. in the context of service-oriented architectures (SOA). The formal modeling of service choreographies enables a model-based integration testing (MBIT) approach. We present MBIT methods for our service choreography modeling approach called Message Choreography Models (MCM). For the model-based testing of service choreographies, MCMs are translated into Event-B models and used as input for our test generator which uses the model checker ProB.

  18. Perturbation theory for graphene integrated waveguides: cubic nonlinearity and third harmonic generation

    CERN Document Server

    Gorbach, Andrey V

    2016-01-01

    We present perturbation theory for analysis of generic third-order nonlinear processes in graphene integrated photonic structures. Optical response of graphene is treated as the nonlinear boundary condition in Maxwell equations. The derived models are applied for analysis of third harmonic generation in a graphene coated dielectric micro-fibre. The efficiency of up to few percent is predicted when using sub-picosecond pump pulses with energies of the order of $0.1$nJ in a sub-millimeter long fibre, when operating near the resonance of the graphene nonlinear conductivity $\\hbar\\omega=(2/3)E_F$.

  19. Online integrated solution to collect data, generate information and manage events in the human biomonitoring field.

    Science.gov (United States)

    Reis, M Fátima; Tedim, João; Aguiar, Pedro; Miguel, J Pereira; Casteleyn, Ludwine; Joas, Reinhard; Van Tongelen, Birgit

    2007-05-01

    In the ambit of Work Package 1 of the ESBIO Project, an online integrated solution to collect data, to generate information, and to manage mainly information-sharing events related with human biomonitoring within Europe has been designed and is being implemented. The present paper summarises the methodological approaches used by the authors as proposers, general promoters and disseminators of this strategic concept, as well as the first outcomes and future actions to be taken, in the short and longer term, to face present and future challenges to make this innovative solution happen.

  20. Optical microwave generation using two parallel DFB lasers integrated with Y-branch waveguide coupler

    Institute of Scientific and Technical Information of China (English)

    Xie Hong-Yun; Wang Lu; Zhao Ling-Juan; Zhu Hong-Liang; Wang Wei

    2007-01-01

    A new device of two parallel distributed feedback (DFB) lasers integrated monolithically with Y-branch waveguide coupler was fabricated by means of quantum well intermixing. Optical microwave signal was generated in the Y-branch waveguide coupler through frequency beating of the two laser modes coming from two DFB laser in parallel, which had a small difference in frequency. Continuous rapid tuning of optical microwave signal from 13 to 42 GHz were realized by adjusting independently the driving currents injected into the two DFB lasers.

  1. SEMICONDUCTOR INTEGRATED CIRCUITS: Soft error generation analysis in combinational logic circuits

    Science.gov (United States)

    Qian, Ding; Yu, Wang; Rong, Luo; Hui, Wang; Huazhong, Yang

    2010-09-01

    Reliability is expected to become a big concern in future deep sub-micron integrated circuits design. Soft error rate (SER) of combinational logic is considered to be a great reliability problem. Previous SER analysis and models indicated that glitch width has a great impact on electrical masking and latch window masking effects, but they failed to achieve enough insights. In this paper, an analytical glitch generation model is proposed. This model shows that after an inflexion point the collected charge has an exponential relationship with glitch duration and the model only introduces an estimation error of on average 2.5%.

  2. In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion.

    Science.gov (United States)

    Maechler, Pierre; Carobbio, Stefania; Rubi, Blanca

    2006-01-01

    Pancreatic beta-cells are unique neuroendocrine cells displaying the peculiar feature of responding to nutrients, principally glucose, as primary stimulus. This requires translation of a metabolic substrate into intracellular messengers recognized by the exocytotic machinery. Central to this signal transduction mechanism, mitochondria integrate and generate metabolic signals, thereby coupling glucose recognition to insulin secretion. In response to a glucose rise, nucleotides and metabolites are generated by mitochondria and participate, together with cytosolic calcium, to the stimulation of insulin exocytosis. This review describes the mitochondrion-dependent pathways of regulated insulin secretion. In particular, importance of cataplerotic and anaplerotic processes is discussed, with special attention to the mitochondrial enzyme glutamate dehydrogenase. Mitochondrial defects, such as mutations and reactive oxygen species production, are presented in the context of beta-cell failure in the course of type 2 diabetes.

  3. Integration of a finite element generator model into a simulated HVDC connected system

    Energy Technology Data Exchange (ETDEWEB)

    Preston, T.W.; Sturgess, J.P. [GEC Alsthom Engineering Research Center, Stafford (United Kingdom)

    1994-12-31

    Within most system analysis programs generators and motors are represented by an equivalent circuit model either a 2-axis model for both stators and rotor or a three-phase model of the stator and a two-axis model of the rotor. This may be adequate under certain operating conditions such as steady-state or some symmetrical faults but for inverter-fed motors or generators feeding into a rectified load a more rigorous model of the machine is required. This paper describes the theory and development of such a model, its integration with the power electronics and application to 6-pulse and 12-pulse converters, the latter being appropriate in systems similar to HVDC unit connection. (author) 5 refs., 16 figs.

  4. Contribution of energy storage for large-scale integration of variable generation

    Energy Technology Data Exchange (ETDEWEB)

    Estanqueiro, Ana [National Laboratory for Energy and Geology (LNEG), Lisbon (Portugal); Aardal, Atle Rygg [SINTEF, Trondheim (Norway); O' Dwyer, Ciara [University College Dublin (UCD) (Ireland)] [and others

    2012-07-01

    The amount of wind power and other time-variable non-dispatchable renewable energy sources (VRES) such as photovoltaics (PV) is rapidly increasing in the world. Several power systems in Europe are already facing a very high penetration from variable renewables which is posing concerns on the operational stability limits that are being surpassed for extreme RES generation conditions. Most transmission system operators are defining VRES limits of penetration, thus, requiring the renewable energy excess to be curtailed, exported or stored. Energy storage may play a relevant role in maximizing the long term penetration of VRES if used as a technical mean to regulate the daily, weekly and annual profiles of variable generation (VG). This paper reviews the storage technologies that are available and may be used on a power system scale and performs a cost/benefit analysis discussing their advantages and disadvantages for the integration of fast-growing renewables, such as wind power and PV. (orig.)

  5. Integrated GaN photonic circuits on silicon (100) for second harmonic generation

    CERN Document Server

    Xiong, Chi; Ryu, Kevin K; Schuck, Carsten; Fong, King Y; Palacios, Tomas; Tang, Hong X

    2014-01-01

    We demonstrate second order optical nonlinearity in a silicon architecture through heterogeneous integration of single-crystalline gallium nitride (GaN) on silicon (100) substrates. By engineering GaN microrings for dual resonance around 1560 nm and 780 nm, we achieve efficient, tunable second harmonic generation at 780 nm. The \\{chi}(2) nonlinear susceptibility is measured to be as high as 16 plus minus 7 pm/V. Because GaN has a wideband transparency window covering ultraviolet, visible and infrared wavelengths, our platform provides a viable route for the on-chip generation of optical wavelengths in both the far infrared and near-UV through a combination of \\{chi}(2) enabled sum-/difference-frequency processes.

  6. IQSeq: integrated isoform quantification analysis based on next-generation sequencing.

    Directory of Open Access Journals (Sweden)

    Jiang Du

    Full Text Available With the recent advances in high-throughput RNA sequencing (RNA-Seq, biologists are able to measure transcription with unprecedented precision. One problem that can now be tackled is that of isoform quantification: here one tries to reconstruct the abundances of isoforms of a gene. We have developed a statistical solution for this problem, based on analyzing a set of RNA-Seq reads, and a practical implementation, available from archive.gersteinlab.org/proj/rnaseq/IQSeq, in a tool we call IQSeq (Isoform Quantification in next-generation Sequencing. Here, we present theoretical results which IQSeq is based on, and then use both simulated and real datasets to illustrate various applications of the tool. In order to measure the accuracy of an isoform-quantification result, one would try to estimate the average variance of the estimated isoform abundances for each gene (based on resampling the RNA-seq reads, and IQSeq has a particularly fast algorithm (based on the Fisher Information Matrix for calculating this, achieving a speedup of ~ 500 times compared to brute-force resampling. IQSeq also calculates an information theoretic measure of overall transcriptome complexity to describe isoform abundance for a whole experiment. IQSeq has many features that are particularly useful in RNA-Seq experimental design, allowing one to optimally model the integration of different sequencing technologies in a cost-effective way. In particular, the IQSeq formalism integrates the analysis of different sample (i.e. read sets generated from different technologies within the same statistical framework. It also supports a generalized statistical partial-sample-generation function to model the sequencing process. This allows one to have a modular, "plugin-able" read-generation function to support the particularities of the many evolving sequencing technologies.

  7. Protein Nano-Object Integrator (ProNOI for generating atomic style objects for molecular modeling

    Directory of Open Access Journals (Sweden)

    Smith Nicholas

    2012-12-01

    Full Text Available Abstract Background With the progress of nanotechnology, one frequently has to model biological macromolecules simultaneously with nano-objects. However, the atomic structures of the nano objects are typically not available or they are solid state entities. Because of that, the researchers have to investigate such nano systems by generating models of the nano objects in a manner that the existing software be able to carry the simulations. In addition, it should allow generating composite objects with complex shape by combining basic geometrical figures and embedding biological macromolecules within the system. Results Here we report the Protein Nano-Object Integrator (ProNOI which allows for generating atomic-style geometrical objects with user desired shape and dimensions. Unlimited number of objects can be created and combined with biological macromolecules in Protein Data Bank (PDB format file. Once the objects are generated, the users can use sliders to manipulate their shape, dimension and absolute position. In addition, the software offers the option to charge the objects with either specified surface or volumetric charge density and to model them with user-desired dielectric constants. According to the user preference, the biological macromolecule atoms can be assigned charges and radii according to four different force fields: Amber, Charmm, OPLS and PARSE. The biological macromolecules and the atomic-style objects are exported as a position, charge and radius (PQR file, or if a default dielectric constant distribution is not selected, it is exported as a position, charge, radius and epsilon (PQRE file. As illustration of the capabilities of the ProNOI, we created a composite object in a shape of a robot, aptly named the Clemson Robot, whose parts are charged with various volumetric charge densities and holds the barnase-barstar protein complex in its hand. Conclusions The Protein Nano-Object Integrator (ProNOI is a convenient tool for

  8. Protein Nano-Object Integrator (ProNOI) for generating atomic style objects for molecular modeling.

    Science.gov (United States)

    Smith, Nicholas; Campbell, Brandon; Li, Lin; Li, Chuan; Alexov, Emil

    2012-12-05

    With the progress of nanotechnology, one frequently has to model biological macromolecules simultaneously with nano-objects. However, the atomic structures of the nano objects are typically not available or they are solid state entities. Because of that, the researchers have to investigate such nano systems by generating models of the nano objects in a manner that the existing software be able to carry the simulations. In addition, it should allow generating composite objects with complex shape by combining basic geometrical figures and embedding biological macromolecules within the system. Here we report the Protein Nano-Object Integrator (ProNOI) which allows for generating atomic-style geometrical objects with user desired shape and dimensions. Unlimited number of objects can be created and combined with biological macromolecules in Protein Data Bank (PDB) format file. Once the objects are generated, the users can use sliders to manipulate their shape, dimension and absolute position. In addition, the software offers the option to charge the objects with either specified surface or volumetric charge density and to model them with user-desired dielectric constants. According to the user preference, the biological macromolecule atoms can be assigned charges and radii according to four different force fields: Amber, Charmm, OPLS and PARSE. The biological macromolecules and the atomic-style objects are exported as a position, charge and radius (PQR) file, or if a default dielectric constant distribution is not selected, it is exported as a position, charge, radius and epsilon (PQRE) file. As illustration of the capabilities of the ProNOI, we created a composite object in a shape of a robot, aptly named the Clemson Robot, whose parts are charged with various volumetric charge densities and holds the barnase-barstar protein complex in its hand. The Protein Nano-Object Integrator (ProNOI) is a convenient tool for generating atomic-style nano shapes in conjunction with

  9. Exergetic Analysis of an Integrated Tri-Generation Organic Rankine Cycle

    Directory of Open Access Journals (Sweden)

    Ratha Z. Mathkor

    2015-08-01

    Full Text Available This paper reports on a study of the modelling, validation and analysis of an integrated 1 MW (electrical output tri-generation system energized by solar energy. The impact of local climatic conditions in the Mediterranean region on the system performance was considered. The output of the system that comprised a parabolic trough collector (PTC, an organic Rankine cycle (ORC, single-effect desalination (SED, and single effect LiBr-H2O absorption chiller (ACH was electrical power, distilled water, and refrigerant load. The electrical power was produced by the ORC which used cyclopentane as working fluid and Therminol VP-1 was specified as the heat transfer oil (HTO in the collectors with thermal storage. The absorption chiller and the desalination unit were utilize the waste heat exiting from the steam turbine in the ORC to provide the necessary cooling energy and drinking water respectively. The modelling, which includes an exergetic analysis, focuses on the performance of the solar tri-generation system. The simulation results of the tri-generation system and its subsystems were produced using IPSEpro software and were validated against experimental data which showed good agreement. The tri-generation system was able to produce about 194 Ton of refrigeration, and 234 t/day distilled water.

  10. Surface Integral Method for the Second Harmonic Generation in Metal Nanoparticles

    CERN Document Server

    Forestiere, Carlo; Miano, Giovanni

    2013-01-01

    Second harmonic (SH) radiation in metal nanoparticles is generated by both nonlocal-bulk and local-surface SH sources, induced by the electromagnetic field at the fundamental frequency. We propose a surface integral equation (SIE) method for evaluating the SH radiation generated by metal nanoparticles with arbitrary shapes, considering both the local-surface and nonlocal-bulk SH sources. We demonstrate that the contribution of the nonlocal-bulk SH source to the SH electromagnetic field can be rigorously taken into account through an equivalent surface magnetic current. We numerically solve the SIE problem by using the Galerkin method and the Rao-Wilton-Glisson basis functions in the framework of the distribution theory. The accuracy of the proposed method is verified by comparison with the SH-Mie formulation in the case of SH generation from a spherical nanoparticle. As an example of a complex-shaped particle, we investigate the SH radiation generated from a triangular nano-prism. The method paves the way for...

  11. The salinity gradient power generating system integrated into the seawater desalination system

    Science.gov (United States)

    Zhu, Yongqiang; Wang, Wanjun; Cai, Bingqian; Hao, Jiacheng; Xia, Ruihua

    2017-01-01

    Seawater desalination is an important way to solve the problem of fresh water shortage. Low energy efficiency and high cost are disadvantages existing in seawater desalination. With huge reserve and the highest energy density among different types of marine energy, salinity gradient energy has a bright application prospect. The promotion of traditional salinity gradient power generating systems is hindered by its low efficiency and specific requirements on site selection. This paper proposes a salinity gradient power generating system integrated into the seawater desalination system which combines the salinity gradient power generating system and the seawater desalination system aiming to remedy the aforementioned deficiency and could serve as references for future seawater desalination and salinity gradient energy exploitation. The paper elaborates on the operating principles of the system, analyzes the detailed working process, and estimates the energy output and consumption of the system. It is proved that with appropriate design, the energy output of the salinity gradient power generating system can satisfy the demand of the seawater desalination system.

  12. Chances for the further integration of decentralized generation by following a grid-driven approach; Moeglichkeiten einer netzorientierten Betriebsweise zur weiteren Integration dezentraler Energieumwandlung auf Verteilnetzebene

    Energy Technology Data Exchange (ETDEWEB)

    Luensdorf, Ontje [OFFIS Oldenburg (Germany); Sonnenschein, Michael [Oldenburg Univ. (Germany); Mohrmann, Michael; Hofmann, Lutz [Hannover Univ. (Germany). IEH FG EE; Gronstedt, Phillip; Kurrat, Michael [TU Braunschweig (Germany). elenia

    2011-07-01

    The integration of renewable energy generation facilities increases the decentralization of electricity supply as well as feed-in fluctuations. Due to grid stability concerns, the integration capability of distribution grids is limited. The Energy Research Alliance of Lower Saxony (FEN) has developed the grid-driven operation mode, which can be used to reduce the feed-in fluctuations by increasing the flexibility of electricity generation, consumption and storage. This article presents simulation results of the grid-driven operation mode in distribution grids with high penetrations of distributed energy generation facilities. (orig.)

  13. A compact, integrated silicon device for the generation of spectrally filtered, pair-correlated photons

    Science.gov (United States)

    Minkov, Momchil; Savona, Vincenzo

    2016-05-01

    The third-order nonlinearity of silicon gives rise to a spontaneous four-wave mixing process in which correlated photon pairs are generated. Sources based on this effect can be used for quantum computation and cryptography, and can in principle be integrated with standard CMOS fabrication technology and components. However, one of the major challenges is the on-chip demultiplexing of the photons, and in particular the filtering of the pump power, which is many orders of magnitude larger than that of the signal and idler photons. Here, we propose a photonic crystal coupled-cavity system designed so that the coupling of the pump mode to the output channel is strictly zero due to symmetry. We further analyze this effect in the presence of fabrication disorder and find that, even then, a pump suppression of close to 40 dB can be achieved in state-of-the-art systems. Due to the small mode volumes and high quality factors, our system is also expected to have a generation efficiency much higher than in standard micro-ring systems. Those two considerations make a strong case for the integration of our proposed design in future on-chip quantum technologies.

  14. Crops In Silico: Generating Virtual Crops Using an Integrative and Multi-scale Modeling Platform.

    Science.gov (United States)

    Marshall-Colon, Amy; Long, Stephen P; Allen, Douglas K; Allen, Gabrielle; Beard, Daniel A; Benes, Bedrich; von Caemmerer, Susanne; Christensen, A J; Cox, Donna J; Hart, John C; Hirst, Peter M; Kannan, Kavya; Katz, Daniel S; Lynch, Jonathan P; Millar, Andrew J; Panneerselvam, Balaji; Price, Nathan D; Prusinkiewicz, Przemyslaw; Raila, David; Shekar, Rachel G; Shrivastava, Stuti; Shukla, Diwakar; Srinivasan, Venkatraman; Stitt, Mark; Turk, Matthew J; Voit, Eberhard O; Wang, Yu; Yin, Xinyou; Zhu, Xin-Guang

    2017-01-01

    Multi-scale models can facilitate whole plant simulations by linking gene networks, protein synthesis, metabolic pathways, physiology, and growth. Whole plant models can be further integrated with ecosystem, weather, and climate models to predict how various interactions respond to environmental perturbations. These models have the potential to fill in missing mechanistic details and generate new hypotheses to prioritize directed engineering efforts. Outcomes will potentially accelerate improvement of crop yield, sustainability, and increase future food security. It is time for a paradigm shift in plant modeling, from largely isolated efforts to a connected community that takes advantage of advances in high performance computing and mechanistic understanding of plant processes. Tools for guiding future crop breeding and engineering, understanding the implications of discoveries at the molecular level for whole plant behavior, and improved prediction of plant and ecosystem responses to the environment are urgently needed. The purpose of this perspective is to introduce Crops in silico (cropsinsilico.org), an integrative and multi-scale modeling platform, as one solution that combines isolated modeling efforts toward the generation of virtual crops, which is open and accessible to the entire plant biology community. The major challenges involved both in the development and deployment of a shared, multi-scale modeling platform, which are summarized in this prospectus, were recently identified during the first Crops in silico Symposium and Workshop.

  15. Generating action descriptions from statistically integrated representations of human motions and sentences.

    Science.gov (United States)

    Takano, Wataru; Kusajima, Ikuo; Nakamura, Yoshihiko

    2016-08-01

    It is desirable for robots to be able to linguistically understand human actions during human-robot interactions. Previous research has developed frameworks for encoding human full body motion into model parameters and for classifying motion into specific categories. For full understanding, the motion categories need to be connected to the natural language such that the robots can interpret human motions as linguistic expressions. This paper proposes a novel framework for integrating observation of human motion with that of natural language. This framework consists of two models; the first model statistically learns the relations between motions and their relevant words, and the second statistically learns sentence structures as word n-grams. Integration of these two models allows robots to generate sentences from human motions by searching for words relevant to the motion using the first model and then arranging these words in appropriate order using the second model. This allows making sentences that are the most likely to be generated from the motion. The proposed framework was tested on human full body motion measured by an optical motion capture system. In this, descriptive sentences were manually attached to the motions, and the validity of the system was demonstrated.

  16. Mission Applicability and Benefits of Thin-Film Integrated Power Generation and Energy Storage

    Science.gov (United States)

    Hoffman, David; Raffaelle, Ryne P.; Landis, Geoffrey A.; Hepp, Aloysius F.

    2001-01-01

    This paper discusses the space mission applicability and benefits of a thin-film integrated power generation and energy storage device, i.e., an "Integrated Power Source" or IPS. The characteristics of an IPS that combines thin-film photo-voltaic power generation with thin-film energy storage are described. Mission concepts for a thin-film IPS as a spacecraft main electrical power system, as a decentralized or distributed power source and as an uninterruptible power supply are discussed. For two specific missions, preliminary sizing of an IPS as a main power system is performed and benefits are assessed. IPS developmental challenges that need to be overcome in order to realize the benefits of an IPS are examined. Based on this preliminary assessment, it is concluded that the most likely and beneficial application of an IPS will be as the main power system on a very small "nanosatellite," or in specialized applications serving as a decentralized or distributed power source or uninterruptible power supply.

  17. Impact of Bridging Income Generation with Group Integrated Care (BIGPIC) on Hypertension and Diabetes in Rural Western Kenya.

    Science.gov (United States)

    Pastakia, Sonak D; Manyara, Simon M; Vedanthan, Rajesh; Kamano, Jemima H; Menya, Diana; Andama, Benjamin; Chesoli, Cleophas; Laktabai, Jeremiah

    2017-05-01

    Rural settings in Sub-Saharan Africa (SSA) consistently report low participation in non-communicable disease (NCD) treatment programs and poor outcomes. The objective of this study is to assess the impact of the implementation of a patient-centered rural NCD care delivery model called Bridging Income Generation through grouP Integrated Care (BIGPIC). The study prospectively tracked participation and health outcomes for participants in a screening event and compared linkage frequencies to a historical comparison group. Rural Kenyan participants attending a voluntary NCD screening event were included within the BIGPIC model of care. The BIGPIC model utilizes a contextualized care delivery model designed to address the unique barriers faced in rural settings. This model emphasizes the following steps: (1) find patients in the community, (2) link to peer/microfinance groups, (3) integrate education, (4) treat in the community, (5) enhance economic sustainability and (6) generate demand for care through incentives. The primary outcome is the linkage frequency, which measures the percentage of patients who return for care after screening positive for either hypertension and/or diabetes. Secondary measures include retention frequencies defined as the percentage of patients remaining engaged in care throughout the 9-month follow-up period and changes in systolic (SBP) and diastolic blood pressure (DBP) and blood sugar over 12 months. Of the 879 individuals who were screened, 14.2 % were confirmed to have hypertension, while only 1.4 % were confirmed to have diabetes. The implementation of a comprehensive microfinance-linked, community-based, group care model resulted in 72.4 % of screen-positive participants returning for subsequent care, of which 70.3 % remained in care through the 12 months of the evaluation period. Patients remaining in care demonstrated a statistically significant mean decline of 21 mmHg in SBP [95 % CI (13.9 to 28.4), P < 0.01] and 5

  18. Canopy in the Clouds: Integrating Science and Media to Inspire a New Generation of Scientists

    Science.gov (United States)

    Goldsmith, G. R.; Fulton, A. D.; Witherill, C. D.

    2008-12-01

    Innovative approaches to science education are critical for inspiring a new generation of scientists. In a world where students are inundated with digital media inviting them to explore exciting, emerging disciplines, science often lags behind in using progressive media techniques. Additionally, science education media often neglects to include the scientists conducting research, thereby disconnecting students from the excitement, adventure, and beauty of conducting research in the field. Here we present initial work from a science education media project entitled Canopy in the Clouds. In particular, we address the goals and approach of the project, the logistics associated with generating educational material at a foreign field site, and the challenges associated with effectively integrating science and media. Canopy in the Clouds is designed to engage students in research, motivate a new generation of young scientists, and promote conservation from the perspective of a current research project being conducted in the canopy of a tropical montane cloud forest located in Monteverde, Costa Rica. The project seeks to generate curriculum based on multiple, immersive forms of novel digital media that attract and maintain student attention. By doing so from the perspective of an adventurous research project in a beautiful and highly biodiverse region, we hope to engage students in science and enhance bioliteracy. However, there are considerable logistic considerations associated with such an approach, including safety, travel, permitting, and equipment maintenance. Additionally, the goals of both the scientific research and the educational media project must be balanced in order to meet objectives in a timely fashion. Finally, materials generated in the field must be translated to viable final products and distributed. Work associated with Canopy in the Clouds will thus provide insight into this process and can serve to inform future science education and outreach

  19. Integrating environmental equity, energy and sustainability: A spatial-temporal study of electric power generation

    Science.gov (United States)

    Touche, George Earl

    The theoretical scope of this dissertation encompasses the ecological factors of equity and energy. Literature important to environmental justice and sustainability are reviewed, and a general integration of global concepts is delineated. The conceptual framework includes ecological integrity, quality human development, intra- and inter-generational equity and risk originating from human economic activity and modern energy production. The empirical focus of this study concentrates on environmental equity and electric power generation within the United States. Several designs are employed while using paired t-tests, independent t-tests, zero-order correlation coefficients and regression coefficients to test seven sets of hypotheses. Examinations are conducted at the census tract level within Texas and at the state level across the United States. At the community level within Texas, communities that host coal or natural gas utility power plants and corresponding comparison communities that do not host such power plants are tested for compositional differences. Comparisons are made both before and after the power plants began operating for purposes of assessing outcomes of the siting process and impacts of the power plants. Relationships between the compositions of the hosting communities and the risks and benefits originating from the observed power plants are also examined. At the statewide level across the United States, relationships between statewide composition variables and risks and benefits originating from statewide electric power generation are examined. Findings indicate the existence of some limited environmental inequities, but they do not indicate disparities that confirm the general thesis of environmental racism put forth by environmental justice advocates. Although environmental justice strategies that would utilize Title VI of the 1964 Civil Rights Act and the disparate impact standard do not appear to be applicable, some findings suggest potential

  20. Evaluation of Novel Integrated Dielectric Barrier Discharge Plasma as Ozone Generator

    Directory of Open Access Journals (Sweden)

    Muhammad Nur

    2017-04-01

    Full Text Available This paper presents a characterization of an integrated ozone generator constructed by seven of reactors of Dielectric Barrier Discharge Plasma (DBDP. DBDP a has spiral-cylindrical configuration. Silence plasma produced ozone inside the DBDP reactor was generated by AC-HV with voltage up to 25 kV and maximum frequency of 23 kHz. As a source of ozone, dry air was pumped into the generator and controlled by valves system and a flowmeter. We found ozone concentration increased with the applied voltage, but in contrary, the concentration decreased with the flow rate of dry air. It was also found that a maximum concentration was 20 mg/L and ozone capacity of 48 g/h with an input power of 1.4 kW. Moreover, in this generator, IP efficiency of 8.13 g/kWh was obtained at input power 0.45 kW and air flow rate of 9 L/min. Therefore, be the higher ozone capacity can be produced with higher input power; however, it provided lower IP efficiency. The effect of dry air flow rate and applied voltage on ozone concentrations have been studied. At last, spiral wire copper was very corrosive done to the interaction with ozone, and it is necessary to do a research for finding the best metals as an active electrode inside of the quartz dielectric. Copyright © 2017 BCREC GROUP. All rights reserved Received: 18th July 2016; Revised: 25th September 2016; Accepted: 5th October 2016 How to Cite: Nur, M., Susan, A.I., Muhlisin, Z., Arianto, F., Kinandana, A.W., Nurhasanah, I., Sumariyah, S., Wibawa, P.J., Gunawan, G., Usman, A. (2017. Evaluation of Novel Integrated Dielectric Barrier Discharge Plasma as Ozone Generator. Bulletin of Chemical Reaction Engineering & Catalysis, 12 (1: 24-31 (doi:10.9767/bcrec.12.1.605.24-31 Permalink/DOI: http://dx.doi.org/10.9767/bcrec.12.1.605.24-31

  1. Development of an Integrated Intelligent Multi -Objective Framework for UAV Trajectory Generation

    Science.gov (United States)

    Wilburn, Jennifer Nicole

    This thesis explores a variety of path planning and trajectory generation schemes intended for small, fixed-wing Unmanned Aerial Vehicles. Throughout this analysis, discrete and pose-based methods are investigated. Pose-based methods are the focus of this research due to their increased flexibility and typically lower computational overhead. Path planning in 3 dimensions is also performed. The 3D Dubins methodology presented is an extension of a previously suggested approach and addresses both the mathematical formulation of the methodology, as well as an assessment of numerical issues encountered and the solutions implemented for these. The main contribution of this thesis is a 3-dimensional clothoid trajectory generation algorithm, which produces flyable paths of continuous curvature to ensure a more followable commanded path. This methodology is an extension of the 3D Dubins method and the 2D clothoid method, which have been implemented herein. To ensure flyability of trajectories produced by 3D pose-based trajectory generation methodologies, a set of criteria are specified to limit the possible solutions to only those flyable by the aircraft. Additionally, several assumptions are made concerning the motion of the aircraft in order to simplify the path generation problem. The 2D and 3D clothoid and Dubins trajectory planners are demonstrated through a trajectory tracking performance comparison between first the 2D Dubins and 2D clothoid methods using a position proportional-integral-derivative controller, then the 3D Dubins and 3D clothoid methods using both a position proportional-integral-derivative controller and an outer-loop non-linear dynamic inversion controller, within the WVU UAV Simulation Environment. These comparisons are demonstrated for both nominal and off-nominal conditions, and show that for both 2D and 3D implementations, the clothoid path planners yields paths with better trajectory tracking performance as compared to the Dubins path planners

  2. Integration of Research for an Exhaust Thermoelectric Generator and the Outer Flow Field of a Car

    Science.gov (United States)

    Jiang, T.; Su, C. Q.; Deng, Y. D.; Wang, Y. P.

    2017-05-01

    The exhaust thermoelectric generator (TEG) can generate electric power from a car engine's waste heat. It is important to maintain a sufficient temperature difference across the thermoelectric modules. The radiator is connected to the cooling units of the thermoelectric modules and used to take away the heat from the TEG system. This paper focuses on the research for the integration of a TEG radiator and the flow field of the car chassis, aiming to cool the radiator by the high speed flow around the chassis. What is more, the TEG radiator is designed as a spoiler to optimize the flow field around the car chassis and even reduce the aerodynamic drag. Concentrating on the flow pressure of the radiator and the aerodynamic drag force, a sedan model with eight different schemes of radiator configurations are studied by computational fluid dynamics simulation. Finally, the simulation results indicate that a reasonable radiator configuration can not only generate high flow pressure to improve the cooling performance, which provides a better support for the TEG system, but also acts as a spoiler to reduce the aerodynamic drag force.

  3. Integration of Research for an Exhaust Thermoelectric Generator and the Outer Flow Field of a Car

    Science.gov (United States)

    Jiang, T.; Su, C. Q.; Deng, Y. D.; Wang, Y. P.

    2016-11-01

    The exhaust thermoelectric generator (TEG) can generate electric power from a car engine's waste heat. It is important to maintain a sufficient temperature difference across the thermoelectric modules. The radiator is connected to the cooling units of the thermoelectric modules and used to take away the heat from the TEG system. This paper focuses on the research for the integration of a TEG radiator and the flow field of the car chassis, aiming to cool the radiator by the high speed flow around the chassis. What is more, the TEG radiator is designed as a spoiler to optimize the flow field around the car chassis and even reduce the aerodynamic drag. Concentrating on the flow pressure of the radiator and the aerodynamic drag force, a sedan model with eight different schemes of radiator configurations are studied by computational fluid dynamics simulation. Finally, the simulation results indicate that a reasonable radiator configuration can not only generate high flow pressure to improve the cooling performance, which provides a better support for the TEG system, but also acts as a spoiler to reduce the aerodynamic drag force.

  4. Mutation analyses of integrated HBV genome in hepatitis B patients

    Institute of Scientific and Technical Information of China (English)

    Peilin Wang; Xiuhai Wang; Shuying Cong; Hongming Ma; Xuecheng Zhang

    2008-01-01

    Little has been learnt in the last 30 years about detection of HBV genome as well as its mutation analysis between hepatitis B fathers (HBF) and their children. In this study, we used nest polymerase chain reaction (PCR), fluorescence in situ hybridization (FISH), and DNA sequencing analysis, to examine the integrated HBV genome in paraffin-embedded testis tissues, which were taken as samples from HBF, and in peripheral blood mononuclear cells (PBMC) from 74 cases of HBFs and their children who were born after their fathers' HBV infection (caHBF). We found that HBV DNA existed in testis tissues, mainly in the basilar parts of the seminiferous tubules, and also in PBMC of HBF. It was also documented that there were point mutations of poly-loci, insertions and deletions of nucleotides in integrated HBV genomes, and the types of gene mutations in the HBFs were similar to those in caHBF. This study addresses the major types of gene mutations in integrated HBV genome in human patients and also presents reliable evidence of possible genetic transmission of hepatitis B.

  5. Handgrip Dynamometry and Patient-Generated Subjective Global Assessment in Patients with Nonresectable Lung Cancer.

    Science.gov (United States)

    Barata, Ana T; Santos, Carla; Cravo, Marília; Vinhas, Maria do Céu; Morais, Catarina; Carolino, Elisabete; Mendes, Lino; Roldão Vieira, Jorge; Fonseca, Jorge

    2017-01-01

    Undernutrition is frequently associated with advanced lung cancer. Accurate nutritional assessment tools are important to provide the proper nutritional therapy. Handgrip dynamometry has already been used in these patients, and the findings suggest that it is a good indicator of nutritional status. The aim of this study was to evaluate the association between nutritional status and handgrip strength (HGS) in patients with nonresectable lung cancer. Cross-sectional study involving thirty-seven subjects with nonresectable lung cancer. Nutritional status was obtained using Patient Generated Subjective Global Assessment (PG-SGA), and muscle function was evaluated by HGS using a Jamar® handgrip dynamometer on the nondominant hand. The results of both methods were compared and correlated. According to PG-SGA, 73% (n = 27) of the patients were moderately undernourished, and 8% (n = 3) were severely undernourished. In total, 81% (n = 30) were undernourished. HGS was below the 50th percentile in 57% of the patients (n = 21). We found a significant association between nutritional status according to PG-SGA and HGS (P = 0.026, CI = 95%). Handgrip dynamometry can be a useful tool to evaluate the functional and nutritional status. It can be included in lung cancer patients evaluation, along with other nutritional assessment tools.

  6. Efficient Generation of Myelinating Oligodendrocytes from Primary Progressive Multiple Sclerosis Patients by Induced Pluripotent Stem Cells

    Directory of Open Access Journals (Sweden)

    Panagiotis Douvaras

    2014-08-01

    Full Text Available Multiple sclerosis (MS is a chronic demyelinating disease of unknown etiology that affects the CNS. While current therapies are primarily directed against the immune system, the new challenge is to address progressive MS with remyelinating and neuroprotective strategies. Here, we develop a highly reproducible protocol to efficiently derive oligodendrocyte progenitor cells (OPCs and mature oligodendrocytes from induced pluripotent stem cells (iPSCs. Key elements of our protocol include adherent cultures, dual SMAD inhibition, and addition of retinoids from the beginning of differentiation, which lead to increased yields of OLIG2 progenitors and high numbers of OPCs within 75 days. Furthermore, we show the generation of viral and integration-free iPSCs from primary progressive MS (PPMS patients and their efficient differentiation to oligodendrocytes. PPMS OPCs are functional, as demonstrated by in vivo myelination in the shiverer mouse. These results provide encouraging advances toward the development of autologous cell therapies using iPSCs.

  7. Integrating planning and design optimization for thermal power generation in developing economies: Designs for Vietnam

    Science.gov (United States)

    Pham, John Dinh Chuong

    In the twenty first century, global warming and climate change have become environmental issues worldwide. There is a need to reduce greenhouse gas emissions from thermal power plants through improved efficiency. This need is shared by both developed and developing countries. It is particularly important in rapidly developing economies (for example, Vietnam, South Korea, and China) where there is very significant need to increase generation capacity. This thesis addresses improving thermal power plant efficiency through an improved planning process that emphasizes integrated design. With the integration of planning and design considerations of key components in thermal electrical generation, along with the selection of appropriate up-to-date technologies, greater efficiency and reduction of emissions could be achieved. The major barriers to the integration of overall power plant optimization are the practice of individual island tendering packages, and the lack of coordinating efforts between major original equipment manufacturers (OEM). This thesis assesses both operational and design aspects of thermal power plants to identify opportunities for energy saving and the associated reduction of CO2 emissions. To demonstrate the potential of the integrated planning design approach, three advanced thermal power plants, using anthracite coal, oil and gas as their respective fuel, were developed as a case study. The three plant formulations and simulations were performed with the cooperation of several leading companies in the power industry including Babcock & Wilcox, Siemens KWU, Siemens-Westinghouse Power Corporation, Hitachi, Alstom Air Preheater, TLT-Covent, and ABB Flakt. The first plant is a conventional W-Flame anthracite coal-fired unit for base load operation. The second is a supercritical oil-fired plant with advanced steam condition, for two shifting and cycling operations. The third plant is a gas-fired combined cycle unit employing a modern steam-cooled gas

  8. A second generation integrated map of the rainbow trout (Oncorhynchus mykiss) genome: analysis of synteny with model fish genomes

    Science.gov (United States)

    In this paper we generated DNA fingerprints and end sequences from bacterial artificial chromosomes (BACs) from two new libraries to improve the first generation integrated physical and genetic map of the rainbow trout (Oncorhynchus mykiss) genome. The current version of the physical map is compose...

  9. Developing next-generation telehealth tools and technologies: patients, systems, and data perspectives.

    Science.gov (United States)

    Ackerman, Michael J; Filart, Rosemarie; Burgess, Lawrence P; Lee, Insup; Poropatich, Ronald K

    2010-01-01

    The major goals of telemedicine today are to develop next-generation telehealth tools and technologies to enhance healthcare delivery to medically underserved populations using telecommunication technology, to increase access to medical specialty services while decreasing healthcare costs, and to provide training of healthcare providers, clinical trainees, and students in health-related fields. Key drivers for these tools and technologies are the need and interest to collaborate among telehealth stakeholders, including patients, patient communities, research funders, researchers, healthcare services providers, professional societies, industry, healthcare management/economists, and healthcare policy makers. In the development, marketing, adoption, and implementation of these tools and technologies, communication, training, cultural sensitivity, and end-user customization are critical pieces to the process. Next-generation tools and technologies are vehicles toward personalized medicine, extending the telemedicine model to include cell phones and Internet-based telecommunications tools for remote and home health management with video assessment, remote bedside monitoring, and patient-specific care tools with event logs, patient electronic profile, and physician note-writing capability. Telehealth is ultimately a system of systems in scale and complexity. To cover the full spectrum of dynamic and evolving needs of end-users, we must appreciate system complexity as telehealth moves toward increasing functionality, integration, interoperability, outreach, and quality of service. Toward that end, our group addressed three overarching questions: (1) What are the high-impact topics? (2) What are the barriers to progress? and (3) What roles can the National Institutes of Health and its various institutes and centers play in fostering the future development of telehealth?

  10. Integrating monitor alarms with laboratory test results to enhance patient deterioration prediction.

    Science.gov (United States)

    Bai, Yong; Do, Duc H; Harris, Patricia Rae Eileen; Schindler, Daniel; Boyle, Noel G; Drew, Barbara J; Hu, Xiao

    2015-02-01

    Patient monitors in modern hospitals have become ubiquitous but they generate an excessive number of false alarms causing alarm fatigue. Our previous work showed that combinations of frequently co-occurring monitor alarms, called SuperAlarm patterns, were capable of predicting in-hospital code blue events at a lower alarm frequency. In the present study, we extend the conceptual domain of a SuperAlarm to incorporate laboratory test results along with monitor alarms so as to build an integrated data set to mine SuperAlarm patterns. We propose two approaches to integrate monitor alarms with laboratory test results and use a maximal frequent itemsets mining algorithm to find SuperAlarm patterns. Under an acceptable false positive rate FPRmax, optimal parameters including the minimum support threshold and the length of time window for the algorithm to find the combinations of monitor alarms and laboratory test results are determined based on a 10-fold cross-validation set. SuperAlarm candidates are generated under these optimal parameters. The final SuperAlarm patterns are obtained by further removing the candidates with false positive rate>FPRmax. The performance of SuperAlarm patterns are assessed using an independent test data set. First, we calculate the sensitivity with respect to prediction window and the sensitivity with respect to lead time. Second, we calculate the false SuperAlarm ratio (ratio of the hourly number of SuperAlarm triggers for control patients to that of the monitor alarms, or that of regular monitor alarms plus laboratory test results if the SuperAlarm patterns contain laboratory test results) and the work-up to detection ratio, WDR (ratio of the number of patients triggering any SuperAlarm patterns to that of code blue patients triggering any SuperAlarm patterns). The experiment results demonstrate that when varying FPRmax between 0.02 and 0.15, the SuperAlarm patterns composed of monitor alarms along with the last two laboratory test results

  11. Synthesis of anisotropic swirling surface acoustic waves by inverse filter, towards integrated generators of acoustical vortices

    CERN Document Server

    Riaud, Antoine; Charron, Eric; Bussonnière, Adrien; Matar, Olivier Bou

    2015-01-01

    From radio-electronics signal analysis to biological samples actuation, surface acoustic waves (SAW) are involved in a multitude of modern devices. Despite this versatility, SAW transducers developed up to date only authorize the synthesis of the most simple standing or progressive waves such as plane and focused waves. In particular, acoustical integrated sources able to generate acoustical vortices (the analogue of optical vortices) are missing. In this work, we propose a flexible tool based on inverse filter technique and arrays of SAW transducers enabling the synthesis of prescribed complex wave patterns at the surface of anisotropic media. The potential of this setup is illustrated by the synthesis of a 2D analog of 3D acoustical vortices, namely "swirling surface acoustic waves". Similarly to their 3D counterpart, they appear as concentric structures of bright rings with a phase singularity in their center resulting in a central dark spot. Swirling SAW can be useful in fragile sensors whose neighborhood...

  12. Integrating renewable energy sources in the Portuguese power system. New generation adequacy indicators

    Energy Technology Data Exchange (ETDEWEB)

    Martins, Nuno; Santos, Joana; Damas, Manuela [Redes Energeticas Nacionais (REN), Porto (Portugal). Studies and Innovation Dept.

    2012-07-01

    The penetration of intermittent energy sources in the Portuguese power system is growing significantly. The identification of possible solutions to maintain the operational reserve levels is necessary to preserve flexibility and security of electricity supply. In this context, the development of probabilistic tools is essential to calculate new generation adequacy indicators associated with the analysis of the operational reserve. In this paper, the mathematical model RESERVAS, is briefly described and is used to analyse the impact of integrating high levels of intermittent energy sources in the Portuguese power system. The presented results allow us to conclude that the electricity adequacy evaluation should be done using probabilistic indicators, which reflect the power system performance in the following areas: (i) Adequacy (evaluation of the available power to face the hourly electricity demand) and (ii) Security (evaluation of the operational reserve requirements through the deviations in the demand-supply balance that occur among all elementary periods). (orig.)

  13. An Integrated Optics beam combiner for the second generation VLTI instruments

    CERN Document Server

    Benisty, M; Jocou, L; Labeye, P; Malbet, F; Perraut, K; Kern, P

    2009-01-01

    The very recent years have seen a promising start in scientific publications making use of images produced by near-infrared long-baseline interferometry. The technique has reached, at last, a technical maturity level that opens new avenues for numerous astrophysical topics requiring milli-arcsecond model-independent imaging. The Very Large Telescope Interferometer (VLTI) is on the path to be equipped with instruments capable to combine between four to six telescopes. In the framework of the VLTI second generation instruments Gravity and VSI, we propose a new beam combining concept using Integrated Optics (IO) technologies with a novel ABCD-like fringe encoding scheme. Our goal is to demonstrate that IO-based combination brings considerable advantages in terms of instrumental design and performance. We therefore aim at giving a full characterization of an IO beam combiner to establish its performances and check its compliance with the specifications of an imaging instrument. Laboratory measurements were made i...

  14. Model predictive control system and method for integrated gasification combined cycle power generation

    Science.gov (United States)

    Kumar, Aditya; Shi, Ruijie; Kumar, Rajeeva; Dokucu, Mustafa

    2013-04-09

    Control system and method for controlling an integrated gasification combined cycle (IGCC) plant are provided. The system may include a controller coupled to a dynamic model of the plant to process a prediction of plant performance and determine a control strategy for the IGCC plant over a time horizon subject to plant constraints. The control strategy may include control functionality to meet a tracking objective and control functionality to meet an optimization objective. The control strategy may be configured to prioritize the tracking objective over the optimization objective based on a coordinate transformation, such as an orthogonal or quasi-orthogonal projection. A plurality of plant control knobs may be set in accordance with the control strategy to generate a sequence of coordinated multivariable control inputs to meet the tracking objective and the optimization objective subject to the prioritization resulting from the coordinate transformation.

  15. STUDY ON THE MAIN ASPECT RELATED TO COSTS, GENERATED BY INTEGRATED SYSTEMS IN THE BUSINESS

    Directory of Open Access Journals (Sweden)

    CEAUSESCU AURELIAN IONUT

    2014-08-01

    Full Text Available Under the conditions in which the world for some time past threshold Internet era, many Romanian companies yet reducing management applications accounting programs to CIEL, Win a Mentor or ASCON. It is true that the statement should not be generalized, so that, however, the market Enterprise Resource Planning (ERP has evolved, but we must admit that we are still far from being connected to the reality generated by globalisation of technological markets. In other words, for developed countries in terms of technology, ERP constitute the pinnacle of development over five decades of the techniques of economic administration support beneficiary technologies of information. Main challenge consists of the economic integration of all processes and optimize available resources of a global market.. In our country, however, things are different, and about a tradition in Romanian develop IT systems we can't talk about, though without too much excitement..

  16. Identification of advantageous electricity generation options in sub-Saharan Africa integrating existing resources

    Science.gov (United States)

    Szabó, Sándor; Moner-Girona, Magda; Kougias, Ioannis; Bailis, Rob; Bódis, Katalin

    2016-10-01

    Pioneering approaches are needed to accelerate universal access to electricity while simultaneously transitioning to reliable, sustainable and affordable energy systems. In sub-Saharan Africa (SSA), the challenges lie in attracting the private sector to complement public investments. Here, we present an integrated ‘low-hanging-fruit’ approach aimed at boosting private investment and speeding up the deployment of renewable energy systems in SSA. We analyse the potential of existing energy infrastructure, where a significant upfront investment has already been made, to be exploited for electricity generation. We develop a comprehensive methodology to identify and select suitable locations in SSA and estimate their potential for exploitation. These locations have been further analysed in terms of power capacity potential, electricity output, investments needed and population to be benefited. This strategy to attract additional finance can easily be reproduced, engaging private investors while simultaneously helping to achieve the United Nations (UN) Sustainable Development Goals on energy.

  17. Arbitrary waveform generator and differentiator employing an integrated optical pulse shaper.

    Science.gov (United States)

    Liao, Shasha; Ding, Yunhong; Dong, Jianji; Yang, Ting; Chen, Xiaolin; Gao, Dingshan; Zhang, Xinliang

    2015-05-04

    We propose and demonstrate an optical arbitrary waveform generator and high-order photonic differentiator based on a four-tap finite impulse response (FIR) silicon-on-insulator (SOI) on-chip circuit. Based on amplitude and phase modulation of each tap controlled by thermal heaters, we obtain several typical waveforms such as triangular waveform, sawtooth waveform, square waveform and Gaussian waveform, etc., assisted by an optical frequency comb injection. Unlike other proposed schemes, our scheme does not require a spectral disperser which is difficult to fabricate on chip with high resolution. In addition, we demonstrate first-, second- and third-order differentiators based on the optical pulse shaper. Our scheme can switch the differentiator patterns from first- to third-order freely. In addition, our scheme has distinct advantages of compactness, capability for integration with electronics.

  18. Torque Distribution Strategy for Integrated Starter/ Generator Hybrid Bus Implemented by Fuzzy Algorithm

    Institute of Scientific and Technical Information of China (English)

    ZHONG Hu; AO Guo-qiang; WANG Feng; MA Zi-lin; MAO Xiao-jian; ZHUO Bin

    2008-01-01

    A torque distribution strategy was designed by using fuzzy logic to realize the optimal control. Thevehicle load zones were dynamically divided into several zones by several torque lines to indicate the driversdemand and the high or low efficient operating areas of the diesel engine. The fuzzy logic controller withtrapezoid membership function and Mamdani rule reference mechanism was utilized. There are over 100 rulesused in this fuzzy-based torque distribution strategy which are sorted into four rule-bases. The fuel economyand acceleration tests were designed to test and validate the integrated starter/generator (ISG) bus perfor-mance using fuzzy-based torque distribution strategy. The fuel economy is improved 7.7% compared with therule-based strategy. Finally the road test results reveal that there is about 157% improvement of fuel economy.And the 0-50 km/h acceleration time is 9.5% shorter than the original bus.

  19. Techno-Economic Analysis of Integrating First and Second-Generation Ethanol Production Using Filamentous Fungi: An Industrial Case Study

    Directory of Open Access Journals (Sweden)

    Karthik Rajendran

    2016-05-01

    Full Text Available The 2nd generation plants producing ethanol from lignocelluloses demand risky and high investment costs. This paper presents the energy- and economical evaluations for integrating lignocellulose in current 1st generation dry mill ethanol processes, using filamentous fungi. Dry mills use grains and have mills, liquefactions, saccharifications, fermentation, and distillation to produce ethanol, while their stillage passes centrifugation, and evaporation to recycle the water and dry the cake and evaporated syrup into animal feed. In this work, a bioreactor was considered to cultivate fungi on the stillage either before or after the centrifugation step together with pretreated lignocellulosic wheat bran. The results showed that the integrated 1st and 2nd generation ethanol process requires a capital investment of 77 million USD, which could yield NPV of 162 million USD after 20 years. Compared to the fungal cultivation on thin stillage modified 1st generation process, the integrated process resulted in 53 million USD higher NPV. The energy analysis showed that the thin stillage modified 1st generation process could reduce the overall energy consumption by 2.5% and increase the ethanol production by 4%. Such modifications in the 1st generation processes and integration concepts could be interesting for the ethanol industries, as integrating lignocelluloses to their existing setup requires less capital investment.

  20. An integrated device with high performance multi-function generators and time-to-digital convertors

    Science.gov (United States)

    Qin, X.; Shi, Z.; Xie, Y.; Wang, L.; Rong, X.; Jia, W.; Zhang, W.; Du, J.

    2017-01-01

    A highly integrated, high performance, and re-configurable device, which is designed for the Nitrogen-Vacancy (N-V) center based quantum applications, is reported. The digital compartment of the device is fully implemented in a Field-Programmable-Gate-Array (FPGA). The digital compartment is designed to manage the multi-function digital waveform generation and the time-to-digital convertors. The device provides two arbitrary-waveform-generator channels which operate at a 1 Gsps sampling rate with a maximum bandwidth of 500 MHz. There are twelve pulse channels integrated in the device with a 50 ps time resolution in both duration and delay. The pulse channels operate with the 3.3 V transistor-transistor logic. The FPGA-based time-to-digital convertor provides a 23-ps time measurement precision. A data accumulation module, which can record the input count rate and the distributions of the time measurement, is also available. A digital-to-analog convertor board is implemented as the analog compartment, which converts the digital waveforms to analog signals with 500 MHz lowpass filters. All the input and output channels of the device are equipped with 50 Ω SubMiniature version A termination. The hardware design is modularized thus it can be easily upgraded with compatible components. The device is suitable to be applied in the quantum technologies based on the N-V centers, as well as in other quantum solid state systems, such as quantum dots, phosphorus doped in silicon, and defect spins in silicon carbide.

  1. Structural integrity assessments of steam generator tubes using the FAD methodology

    Energy Technology Data Exchange (ETDEWEB)

    Bergant, Marcos A., E-mail: marcos.bergant@cab.cnea.gov.ar [Gerencia CAREM, Centro Atómico Bariloche (CNEA), Av. Bustillo 9500, San Carlos de Bariloche 8400 (Argentina); Yawny, Alejandro A., E-mail: yawny@cab.cnea.gov.ar [División Física de Metales, Centro Atómico Bariloche (CNEA)/CONICET, Av. Bustillo 9500, San Carlos de Bariloche 8400 (Argentina); Perez Ipiña, Juan E., E-mail: juan.perezipina@fain.uncoma.edu.ar [Grupo Mecánica de Fractura, Universidad Nacional del Comahue/CONICET, Buenos Aires 1400, Neuquén 8300 (Argentina)

    2015-12-15

    Highlights: • The Failure Assessment Diagram (FAD) is used to assess cracked steam generator tubes. • Typical loading conditions and reported tensile and fracture properties are used. • The FAD is capable to predict the failure mode for different cracks and loads. • The FAD can be used to reduce the conservatism of the current plugging criteria. • Appropriate tensile and fracture properties at operating conditions are required. - Abstract: Steam generator tubes (SGTs) represents up to 60% of the total primary pressure retaining boundary area of a nuclear power plant. They have been found susceptible to diverse degradation mechanisms during service. Due to the significance of a SGT failure on the plant safe operation, nuclear regulatory authorities have established tube plugging or repairing criteria which are based on the defect depth. The widespreadly used “40% criterion” proposed in the 70s is an example whose use is still recommended in the last editions of the ASME Boiler and Pressure Vessel Code. In the present work, an alternative, more realistic and less conservative methodology for SGT integrity evaluation is proposed. It is based on the Failure Assessment Diagram (FAD) and takes advantage of the recent developments in non-destructive techniques which allow a more comprehensive characterization of tube defects, i.e., depth, length, orientation and type. The proposed approach has been applied to: the study of the influence of primary and secondary stresses on tube integrity; the prediction of failure mode (i.e., ductile fracture or plastic collapse) of defective SGTs for varied crack geometries and loading conditions; the analysis of the sensibility of tensile and fracture properties with temperature. The potentiality of the FAD as a comprehensive methodology for predicting the failure loads and failure modes of flawed SGTs is highlighted.

  2. Integrating Publicly Available Data to Generate Computationally Predicted Adverse Outcome Pathways for Fatty Liver.

    Science.gov (United States)

    Bell, Shannon M; Angrish, Michelle M; Wood, Charles E; Edwards, Stephen W

    2016-04-01

    Newin vitrotesting strategies make it possible to design testing batteries for large numbers of environmental chemicals. Full utilization of the results requires knowledge of the underlying biological networks and the adverse outcome pathways (AOPs) that describe the route from early molecular perturbations to an adverse outcome. Curation of a formal AOP is a time-intensive process and a rate-limiting step to designing these test batteries. Here, we describe a method for integrating publicly available data in order to generate computationally predicted AOP (cpAOP) scaffolds, which can be leveraged by domain experts to shorten the time for formal AOP development. A network-based workflow was used to facilitate the integration of multiple data types to generate cpAOPs. Edges between graph entities were identified through direct experimental or literature information, or computationally inferred using frequent itemset mining. Data from the TG-GATEs and ToxCast programs were used to channel large-scale toxicogenomics information into a cpAOP network (cpAOPnet) of over 20 000 relationships describing connections between chemical treatments, phenotypes, and perturbed pathways as measured by differential gene expression and high-throughput screening targets. The resulting fatty liver cpAOPnet is available as a resource to the community. Subnetworks of cpAOPs for a reference chemical (carbon tetrachloride, CCl4) and outcome (fatty liver) were compared with published mechanistic descriptions. In both cases, the computational approaches approximated the manually curated AOPs. The cpAOPnet can be used for accelerating expert-curated AOP development and to identify pathway targets that lack genomic markers or high-throughput screening tests. It can also facilitate identification of key events for designing test batteries and for classification and grouping of chemicals for follow up testing.

  3. An integrated device with high performance multi-function generators and time-to-digital convertors.

    Science.gov (United States)

    Qin, X; Shi, Z; Xie, Y; Wang, L; Rong, X; Jia, W; Zhang, W; Du, J

    2017-01-01

    A highly integrated, high performance, and re-configurable device, which is designed for the Nitrogen-Vacancy (N-V) center based quantum applications, is reported. The digital compartment of the device is fully implemented in a Field-Programmable-Gate-Array (FPGA). The digital compartment is designed to manage the multi-function digital waveform generation and the time-to-digital convertors. The device provides two arbitrary-waveform-generator channels which operate at a 1 Gsps sampling rate with a maximum bandwidth of 500 MHz. There are twelve pulse channels integrated in the device with a 50 ps time resolution in both duration and delay. The pulse channels operate with the 3.3 V transistor-transistor logic. The FPGA-based time-to-digital convertor provides a 23-ps time measurement precision. A data accumulation module, which can record the input count rate and the distributions of the time measurement, is also available. A digital-to-analog convertor board is implemented as the analog compartment, which converts the digital waveforms to analog signals with 500 MHz lowpass filters. All the input and output channels of the device are equipped with 50 Ω SubMiniature version A termination. The hardware design is modularized thus it can be easily upgraded with compatible components. The device is suitable to be applied in the quantum technologies based on the N-V centers, as well as in other quantum solid state systems, such as quantum dots, phosphorus doped in silicon, and defect spins in silicon carbide.

  4. Overview of Researches on Social Capital,Human Capital and Social Integration of New Generation Migrant Workers

    Institute of Scientific and Technical Information of China (English)

    Wenjing; LUAN; Honghong; LU; Yulin; TONG; Danna; LU

    2013-01-01

    With urbanization and socio-economic development,new generation migrant workers play an increasingly important role in urban construction. However,for a long time,their social integration situation in inflow places is not ideal. Academic circle has done a lot of researches,but no effective strategy is so far put forward. Through analysis of domestic and foreign researches,it is found that social capital and human capital have an important influence on social integration of new generation migrant workers. This paper takes this as starting point,combines characteristics of new generation migrant workers,and overviews theories and empirical researches of domestic and foreign famous scholars,to explore the relationship between social capital and human capital and social integration of new generation migrant workers.

  5. Fully integrated reflection-mode photoacoustic, two-photon, and second harmonic generation microscopy in vivo

    Science.gov (United States)

    Song, Wei; Xu, Qiang; Zhang, Yang; Zhan, Yang; Zheng, Wei; Song, Liang

    2016-01-01

    The ability to obtain comprehensive structural and functional information from intact biological tissue in vivo is highly desirable for many important biomedical applications, including cancer and brain studies. Here, we developed a fully integrated multimodal microscopy that can provide photoacoustic (optical absorption), two-photon (fluorescence), and second harmonic generation (SHG) information from tissue in vivo, with intrinsically co-registered images. Moreover, using a delicately designed optical-acoustic coupling configuration, a high-frequency miniature ultrasonic transducer was integrated into a water-immersion optical objective, thus allowing all three imaging modalities to provide a high lateral resolution of ~290 nm with reflection-mode imaging capability, which is essential for studying intricate anatomy, such as that of the brain. Taking advantage of the complementary and comprehensive contrasts of the system, we demonstrated high-resolution imaging of various tissues in living mice, including microvasculature (by photoacoustics), epidermis cells, cortical neurons (by two-photon fluorescence), and extracellular collagen fibers (by SHG). The intrinsic image co-registration of the three modalities conveniently provided improved visualization and understanding of the tissue microarchitecture. The reported results suggest that, by revealing complementary tissue microstructures in vivo, this multimodal microscopy can potentially facilitate a broad range of biomedical studies, such as imaging of the tumor microenvironment and neurovascular coupling. PMID:27576922

  6. Fully integrated reflection-mode photoacoustic, two-photon, and second harmonic generation microscopy in vivo

    Science.gov (United States)

    Song, Wei; Xu, Qiang; Zhang, Yang; Zhan, Yang; Zheng, Wei; Song, Liang

    2016-08-01

    The ability to obtain comprehensive structural and functional information from intact biological tissue in vivo is highly desirable for many important biomedical applications, including cancer and brain studies. Here, we developed a fully integrated multimodal microscopy that can provide photoacoustic (optical absorption), two-photon (fluorescence), and second harmonic generation (SHG) information from tissue in vivo, with intrinsically co-registered images. Moreover, using a delicately designed optical-acoustic coupling configuration, a high-frequency miniature ultrasonic transducer was integrated into a water-immersion optical objective, thus allowing all three imaging modalities to provide a high lateral resolution of ~290 nm with reflection-mode imaging capability, which is essential for studying intricate anatomy, such as that of the brain. Taking advantage of the complementary and comprehensive contrasts of the system, we demonstrated high-resolution imaging of various tissues in living mice, including microvasculature (by photoacoustics), epidermis cells, cortical neurons (by two-photon fluorescence), and extracellular collagen fibers (by SHG). The intrinsic image co-registration of the three modalities conveniently provided improved visualization and understanding of the tissue microarchitecture. The reported results suggest that, by revealing complementary tissue microstructures in vivo, this multimodal microscopy can potentially facilitate a broad range of biomedical studies, such as imaging of the tumor microenvironment and neurovascular coupling.

  7. Structural integrity analysis of the degraded drywell containment at the Oyster Creek Nuclear generating station.

    Energy Technology Data Exchange (ETDEWEB)

    Petti, Jason P.

    2007-01-01

    This study examines the effects of the degradation experienced in the steel drywell containment at the Oyster Creek Nuclear Generating Station. Specifically, the structural integrity of the containment shell is examined in terms of the stress limits using the ASME Boiler and Pressure Vessel (B&PV) Code, Section III, Division I, Subsection NE, and examined in terms of buckling (stability) using the ASME B&PV Code Case N-284. Degradation of the steel containment shell (drywell) at Oyster Creek was first observed during an outage in the mid-1980s. Subsequent inspections discovered reductions in the shell thickness due to corrosion throughout the containment. Specifically, significant corrosion occurred in the sandbed region of the lower sphere. Since the presence of the wet sand provided an environment which supported corrosion, a series of analyses were conducted by GE Nuclear Energy in the early 1990s. These analyses examined the effects of the degradation on the structural integrity. The current study adopts many of the same assumptions and data used in the previous GE study. However, the additional computational recourses available today enable the construction of a larger and more sophisticated structural model.

  8. Integrative Medicine Patients Have High Stress, Pain, and Psychological Symptoms.

    Science.gov (United States)

    Wolever, Ruth Q; Goel, Nikita S; Roberts, Rhonda S; Caldwell, Karen; Kligler, Benjamin; Dusek, Jeffery A; Perlman, Adam; Dolor, Rowena; Abrams, Donald I

    2015-01-01

    Integrative medicine (IM) is a rapidly growing field whose providers report clinical success in treating significant stress, chronic pain, and depressive and anxiety symptoms. While IM therapies have demonstrated efficacy for numerous medical conditions, IM for psychological symptoms has been slower to gain recognition in the medical community. This large, cross-sectional study is the first of its kind to document the psychosocial profiles of 4182 patients at 9 IM clinics that form the BraveNet Practice-Based Research Network (PBRN). IM patients reported higher levels of perceived stress, pain, and depressive symptoms, and lower levels of quality of life compared with national norms. Per provider reports, 60% of patients had at least one of the following: stress (9.3%), fatigue (10.2%), anxiety (7.7%), depression (7.2%), and/or sleep disorders (4.8%). Pain, having both physiological and psychological components, was also included and is the most common condition treated at IM clinics. Those with high stress, psychological conditions, and pain were most frequently treated with acupuncture, IM physician consultation, exercise, chiropractic services, diet/nutrition counseling, and massage. With baseline information on clinical presentation and service utilization, future PBRN studies can examine promising interventions delivered at the clinic to treat stress and psychological conditions. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. Real patient learning integrated in a preclinical block musculoskeletal disorders. Does it make a difference?

    Science.gov (United States)

    de Boer, Anne; Melchers, Debbie; Vink, Sylvia; Dekker, Friedo; Beaart, Liesbeth; de Jong, Zuzana

    2011-08-01

    Although musculoskeletal disorders are the most common reason for general practitioner visits, training did not keep pace. Implementation of learning from patients with rheumatologic disorders linked together with the teaching of theoretical knowledge in the preclinical medical education might be an important step forward in the improvement of quality of care for these patients. The Leiden Medical School curriculum has implemented two non-obligatory real patient learning (RPL) practicals integrated within the preclinical block musculoskeletal disorders. This study investigates the educational effectiveness of the practicals, the expectations students have of RPL, and students' satisfaction. Participants' grades on the end-of-block test served as the test results of the educational effectiveness of the practicals and were compared with those of the non-participants. Qualitative data was collected by means of questionnaires generated by focus groups. The participants in practicals scored significantly higher at the end-of-block test. The expected effects of the contact with real patients concerned positive effects on cognition and skills. 'Contextualizing of the theory', 'better memorizing of clinical pictures', and 'understanding of the impact of the disease' were the most frequently mentioned effects of the practicals. Overall, the participants were (very) enthusiastic about this educational format. The RPL practicals integrated within a preclinical block musculoskeletal disorders are a valuable addition to the Leiden medical curriculum. This relatively limited intervention exhibits a strong effect on students' performance in tests. Future research should be directed towards the long-term effects of this intervention.

  10. Using patient experiences as an outcome of integrated care. How to measure it?

    DEFF Research Database (Denmark)

    Nicolaisen, Anne; Fallesen, Anne Kudsk; Rasmussen, Hanna Barbara

    2016-01-01

    and rehabilitation. The purpose of this project is to identify how patients conceptualize clinical integration and how this resembles key features for clinical integration identified by clinicians. Further, we want to develop a patient questionnaire measuring their experience of clinical integration. Method: We...... performed a qualitative literature review to identify articles and reports concerning patient experiences in clinical pathways entailing clinical integration in-between health care and social care. Based on the literature we developed a semi-structured interview guide and conducted 12 patient interviews...... integration. Several questionnaires measured patient experiences on selected themes such as hospital care coordination, patient education, or for selected patient groups. We found a number of reports describing qualitative studies of patient experiences in clinical integration in-between health care, social...

  11. ViralORFeome: an integrated database to generate a versatile collection of viral ORFs.

    Science.gov (United States)

    Pellet, J; Tafforeau, L; Lucas-Hourani, M; Navratil, V; Meyniel, L; Achaz, G; Guironnet-Paquet, A; Aublin-Gex, A; Caignard, G; Cassonnet, P; Chaboud, A; Chantier, T; Deloire, A; Demeret, C; Le Breton, M; Neveu, G; Jacotot, L; Vaglio, P; Delmotte, S; Gautier, C; Combet, C; Deleage, G; Favre, M; Tangy, F; Jacob, Y; Andre, P; Lotteau, V; Rabourdin-Combe, C; Vidalain, P O

    2010-01-01

    Large collections of protein-encoding open reading frames (ORFs) established in a versatile recombination-based cloning system have been instrumental to study protein functions in high-throughput assays. Such 'ORFeome' resources have been developed for several organisms but in virology, plasmid collections covering a significant fraction of the virosphere are still needed. In this perspective, we present ViralORFeome 1.0 (http://www.viralorfeome.com), an open-access database and management system that provides an integrated set of bioinformatic tools to clone viral ORFs in the Gateway(R) system. ViralORFeome provides a convenient interface to navigate through virus genome sequences, to design ORF-specific cloning primers, to validate the sequence of generated constructs and to browse established collections of virus ORFs. Most importantly, ViralORFeome has been designed to manage all possible variants or mutants of a given ORF so that the cloning procedure can be applied to any emerging virus strain. A subset of plasmid constructs generated with ViralORFeome platform has been tested with success for heterologous protein expression in different expression systems at proteome scale. ViralORFeome should provide our community with a framework to establish a large collection of virus ORF clones, an instrumental resource to determine functions, activities and binding partners of viral proteins.

  12. Integrated doses calculation in evacuation scenarios of the neutron generator facility at Missouri S&T

    Science.gov (United States)

    Sharma, Manish K.; Alajo, Ayodeji B.

    2016-08-01

    Any source of ionizing radiations could lead to considerable dose acquisition to individuals in a nuclear facility. Evacuation may be required when elevated levels of radiation is detected within a facility. In this situation, individuals are more likely to take the closest exit. This may not be the most expedient decision as it may lead to higher dose acquisition. The strategy followed in preventing large dose acquisitions should be predicated on the path that offers least dose acquisition. In this work, the neutron generator facility at Missouri University of Science and Technology was analyzed. The Monte Carlo N-Particle (MCNP) radiation transport code was used to model the entire floor of the generator's building. The simulated dose rates in the hallways were used to estimate the integrated doses for different paths leading to exits. It was shown that shortest path did not always lead to minimum dose acquisition and the approach was successful in predicting the expedient path as opposed to the approach of taking the nearest exit.

  13. Integrity of high-velocity water slug generated by an impacting technique

    Science.gov (United States)

    Dehkhoda, Sevda; Bourne, Neil

    2013-06-01

    A pulsed water jet is a series of discrete water slugs travelling at high velocity. Immediately after striking a target, these slugs apply high-intensity, short-duration transient stress known as the water hammer pressure, followed by low-intensity, long-duration stationary stress at the stagnation pressure. The magnitude and duration of the water hammer and stagnation pressures are controlled by the size and quality of the water slugs. The use of water jets for rock cutting in mining operations is a centuries-old technology; however, practical methods for producing high-energy water slugs repeatedly have proven difficult. This can be partly due to the fact that the geometrical properties of a jet and so its effectiveness in creating damage is controlled and influenced by the method that is employed to generate the water slugs. This paper investigates the integrity of a single water slug produced using an impacting technique where a hammer strikes a piston, resting on top of a water-filled chamber. The coherence of the generated water pulse was of concern in this study. If repeated shock reflections within the chamber were transmitted or were carried into the internal geometry of nozzle, the emerging jet could pulsate. The impact impulse of the formed water jet was measured in a Kel-F target material using an embedded PVDF (Polyvinylidene fluoride) shock gauge. The recorded stress waveform was then used to study the quality and endurance of the water pulse stream as it travelled through air.

  14. Optimization Routine for Generating Medical Kits for Spaceflight Using the Integrated Medical Model

    Science.gov (United States)

    Graham, Kimberli; Myers, Jerry; Goodenow, Deb

    2017-01-01

    The Integrated Medical Model (IMM) is a MATLAB model that provides probabilistic assessment of the medical risk associated with human spaceflight missions.Different simulations or profiles can be run in which input conditions regarding both mission characteristics and crew characteristics may vary. For each simulation, the IMM records the total medical events that occur and “treats” each event with resources drawn from import scripts. IMM outputs include Total Medical Events (TME), Crew Health Index (CHI), probability of Evacuation (pEVAC), and probability of Loss of Crew Life (pLOCL).The Crew Health Index is determined by the amount of quality time lost (QTL). Previously, an optimization code was implemented in order to efficiently generate medical kits. The kits were optimized to have the greatest benefit possible, given amass and/or volume constraint. A 6-crew, 14-day lunar mission was chosen for the simulation and run through the IMM for 100,000 trials. A built-in MATLAB solver, mixed-integer linear programming, was used for the optimization routine. Kits were generated in 10% increments ranging from 10%-100% of the benefit constraints. Conditions wheremass alone was minimized, volume alone was minimized, and where mass and volume were minimizedjointly were tested.

  15. Integrated doses calculation in evacuation scenarios of the neutron generator facility at Missouri S&T

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, Manish K.; Alajo, Ayodeji B., E-mail: alajoa@mst.edu

    2016-08-11

    Any source of ionizing radiations could lead to considerable dose acquisition to individuals in a nuclear facility. Evacuation may be required when elevated levels of radiation is detected within a facility. In this situation, individuals are more likely to take the closest exit. This may not be the most expedient decision as it may lead to higher dose acquisition. The strategy followed in preventing large dose acquisitions should be predicated on the path that offers least dose acquisition. In this work, the neutron generator facility at Missouri University of Science and Technology was analyzed. The Monte Carlo N-Particle (MCNP) radiation transport code was used to model the entire floor of the generator's building. The simulated dose rates in the hallways were used to estimate the integrated doses for different paths leading to exits. It was shown that shortest path did not always lead to minimum dose acquisition and the approach was successful in predicting the expedient path as opposed to the approach of taking the nearest exit.

  16. A compact, integrated silicon device for the generation of spectrally-filtered, pair-correlated photons

    CERN Document Server

    Minkov, Momchil

    2016-01-01

    The third-order non-linearity of silicon gives rise to a spontaneous four-wave mixing process in which correlated photon pairs are generated. Sources based on this effect can be used for quantum computation and cryptography, and can in principle be integrated with standard CMOS fabrication technology and components. However, one of the major challenges is the on-chip demultiplexing of the photons, and in particular the filtering of the pump power, which is many orders of magnitude larger than that of the signal and idler photons. Here, we propose a photonic crystal coupled-cavity system designed so that the coupling of the pump mode to the output channel is strictly zero due to symmetry. We further analyze this effect in presence of fabrication disorder and find that, even then, a pump suppression of close to 40 dB can be achieved in state-of-the art systems. Due to the small mode volumes and high quality factors, our system is also expected to have a generation efficiency much higher than in standard micro-r...

  17. Distributed Generation Integration in the Electric Grid: Energy Storage System for Frequency Control

    Directory of Open Access Journals (Sweden)

    Maurizio Delfanti

    2014-01-01

    Full Text Available During the last few years generation from renewable energy sources (RESs has grown considerably in European electrical networks. Transmission system operators are greatly concerned about the impact of RESs on the operational security and efficiency of their networks and more in general of the ENTSO-E interconnected system. Grid codes are to be revised in order to harmonise the rules regarding the connection of RES power plants. A main issue concerns frequency control: frequency is greatly affected by RESs intermittency and its deviations must be limited as much as possible in order to guarantee a suitable level of power quality. To improve frequency stability, in the future, Grid codes could extend frequency control requirements also to RES units, whereas today they are applied only to conventional power plants. Energy storage systems can be a possible solution to increase the flexibility and performance of RES power plants: they allow generators to modulate their power injections without wasting renewable energy. In this paper, the authors studied the suitability of extending frequency control to RES units integrating them with energy storage systems. In particular, the paper focuses on the impact of frequency control on the storage lifetime by analysing the power charge/discharge in response to real frequency oscillations.

  18. Integrating real-time CD corrections into a laser pattern generator

    Science.gov (United States)

    Haddleton, Steven; Ivansen, Lars; Simecek, Michal; Schnitker, Uwe; Stiblert, Lars; Enzinger, Manfred; Roessl, Wolfgang; Sundqvist, Mats; Kalus, Christian K.

    2002-07-01

    Controlling the critical dimension is central in mask manufacturing, and with the ever-shrinking design rule - and hence the increasing requirements on the mask fidelity - new and visionary ways of pushing the envelope of the critical dimension (CD), becomes essential. Research tools and off-line solutions for sizing, proximity correction and other CD compensations have been pursued for some time, but making efficient use of such technologies have been limited by ease-of-use, fracturing and computational time and data volumes associated. Here, we present techniques to deal with these challenges by taking the approach to integrate the solutions into a modern, real-time pattern generator datapath. The solution is based on hierarchical treatment of the patterns in the real-time data path of the pattern generator. By placing it in the real-time domain, we avoid the problem with exploding stream data volumes, and can exploit the parallel architecture and raw computational power of the data path engine.

  19. Treatment of Oil Wastewater and Electricity Generation by Integrating Constructed Wetland with Microbial Fuel Cell

    Directory of Open Access Journals (Sweden)

    Qiao Yang

    2016-11-01

    Full Text Available Conventional oil sewage treatment methods can achieve satisfactory removal efficiency, but energy consumption problems during the process of oil sewage treatment are worth attention. The integration of a constructed wetland reactor and a microbial fuel cell reactor (CW-MFC to treat oil-contaminated wastewater, compared with a microbial fuel cell reactor (MFC alone and a constructed wetland reactor (CW alone, was explored in this research. Performances of the three reactors including chemical oxygen demand (COD, oil removal, and output voltage generation were continuously monitored. The COD removals of three reactors were between 73% and 75%, and oil removals were over 95.7%. Compared with MFC, the CW-MFC with a MnO2 modified cathode produced higher power density and output voltage. Maximum power densities of CW-MFC and MFC were 3868 mW/m3 (102 mW/m2 and 3044 mW/m3 (80 mW/m2, respectively. The plants in CW-MFC play a positive role for reactor cathode potential. Both plants and cathode modification can improve reactor performance of electricity generation.

  20. Prospective Analysis of Life-Cycle Indicators through Endogenous Integration into a National Power Generation Model

    Directory of Open Access Journals (Sweden)

    Diego García-Gusano

    2016-11-01

    Full Text Available Given the increasing importance of sustainability aspects in national energy plans, this article deals with the prospective analysis of life-cycle indicators of the power generation sector through the case study of Spain. A technology-rich, optimisation-based model for power generation in Spain is developed and provided with endogenous life-cycle indicators (climate change, resources, and human health to assess their evolution to 2050. Prospective performance indicators are analysed under two energy scenarios: a business-as-usual one, and an alternative scenario favouring the role of carbon dioxide capture in the electricity production mix by 2050. Life-cycle impacts are found to decrease substantially when existing fossil technologies disappear in the mix (especially coal thermal power plants. In the long term, the relatively high presence of natural gas arises as the main source of impact. When the installation of new fossil options without CO2 capture is forbidden by 2030, both renewable technologies and—to a lesser extent—fossil technologies with CO2 capture are found to increase their contribution to electricity production. The endogenous integration of life-cycle indicators into energy models proves to boost the usefulness of both life cycle assessment and energy systems modelling in order to support decision- and policy-making.

  1. The Eastern Renewable Generation Integration Study: Insights on System Stress: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Bloom, Aaron; Novacheck, Josh

    2017-04-12

    The Eastern Renewable Generation Integration Study (ERGIS) explores the operational impacts of the wide spread adoption of wind and solar photovoltaics (PV) resources in North America's Eastern and Quebec Interconnections. We explore the impact of large scale adoption of wind and solar generation on the unit commitment and economic dispatch of the largest coordinated power system in the world by simulating hourly and five-minute operations. Using NREL's high-performance computing capabilities and new methodologies to model operations, we found that the modeled system, as simulated with evolutionary change in 2026, could balance the variability and uncertainty of wind and solar PV at a five-minute level under a variety of conditions. Our simulations achieve instantaneous penetrations that exceed 50% of load while meeting an annual penetration of 30% on an energy basis. The system meets balanced load and supply in all intervals, with modest curtailment, using technologies and practices that are widely available today. However, a variety of the conditions present in these simulations deviate substantially from historical practice. In this work, we analyze potentially stressful system conditions that occur in the simulations and identify opportunities for innovation, regulatory reform, and changes in operating practices that require further analysis to enable the transition to a system with more wind and solar PV.

  2. Torque Split Strategy for Parallel Hybrid Electric Vehicles with an Integrated Starter Generator

    Directory of Open Access Journals (Sweden)

    Zhumu Fu

    2014-01-01

    Full Text Available This paper presents a torque split strategy for parallel hybrid electric vehicles with an integrated starter generator (ISG-PHEV by using fuzzy logic control. By combining the efficiency map and the optimum torque curve of the internal combustion engine (ICE with the state of charge (SOC of the batteries, the torque split strategy is designed, which manages the ICE within its peak efficiency region. Taking the quantified ICE torque, the quantified SOC of the batteries, and the quantified ICE speed as inputs, and regarding the output torque demanded on the ICE as an output, a fuzzy logic controller (FLC with relevant fuzzy rules has been developed to determine the optimal torque distribution among the ICE, the ISG, and the electric motor/generator (EMG effectively. The simulation results reveal that, compared with the conventional torque control strategy which uses rule-based controller (RBC in different driving cycles, the proposed FLC improves the fuel economy of the ISG-PHEV, increases the efficiency of the ICE, and maintains batteries SOC within its operation range more availably.

  3. Experimental Verification of a Battery Energy Storage System for Integration with Photovoltaic Generators

    Directory of Open Access Journals (Sweden)

    Rajkiran Singh

    2017-01-01

    Full Text Available This paper presents the experimental verification of a 2 kW battery energy storage system (BESS. The BESS comprises a full-bridge bidirectional isolated dc-dc converter and a PWM converter that is intended for integration with a photovoltaic (PV generator, resulting in leveling of the intermittent output power from the PV generator at the utility side. A phase-shift controller is also employed to manage the charging and discharging operations of the BESS based on PV output power and battery voltage. Moreover, a current controller that uses the d-q synchronous reference frame is proposed to regulate the dc voltage at the high-voltage side (HVS to ensure that the voltage ratio of the HVS with low-voltage side (LVS is equivalent to the transformer turns ratio. The proposed controllers allow fast response to changes in real power requirements and results in unity power factor current injection at the utility side. In addition, the efficient active power injection is achieved as the switching losses are minimized. The peak efficiency of the bidirectional isolated dc-dc converter is measured up to 95.4% during battery charging and 95.1% for battery discharging.

  4. Montney unconventional gas : next generation, an integrated approach to optimizing wellbore completions technology

    Energy Technology Data Exchange (ETDEWEB)

    Tapper, N.; Schnell, R. [Talisman Energy Inc., Calgary, AB (Canada)

    2009-07-01

    The Montney Formation is a prolific tight gas reservoir located in the western Canadian Sedimentary Basin in British Columbia and Alberta. The key to achieving economic success in the Peace River Arch area lies with horizontal wells with multiple fractures. The driver for the next generation of completions involves using various area drilling and completion techniques as a starting point to lower the installation cost without affecting the completion or production results. This presentation discussed unconventional gas in the Montney Formation and a next generation, integrated approach to optimizing wellbore completions technology. In order to address the need to change from cemented liners with pump down plugs and perforations completions, the presentation provided background information on swellable packers that could take the place of cement. Swellpacker completion bottom hole assembly and design considerations were presented. A solution for reducing costs was presented along with 6 case histories. It was concluded that new technology is the key to reducing costs in the Montney. Technology must be thoroughly vetted by drilling and completion experts and properly applied. figs.

  5. Integral transform solution of natural convection in a square cavity with volumetric heat generation

    Directory of Open Access Journals (Sweden)

    C. An

    2013-12-01

    Full Text Available The generalized integral transform technique (GITT is employed to obtain a hybrid numerical-analytical solution of natural convection in a cavity with volumetric heat generation. The hybrid nature of this approach allows for the establishment of benchmark results in the solution of non-linear partial differential equation systems, including the coupled set of heat and fluid flow equations that govern the steady natural convection problem under consideration. Through performing the GITT, the resulting transformed ODE system is then numerically solved by making use of the subroutine DBVPFD from the IMSL Library. Therefore, numerical results under user prescribed accuracy are obtained for different values of Rayleigh numbers, and the convergence behavior of the proposed eigenfunction expansions is illustrated. Critical comparisons against solutions produced by ANSYS CFX 12.0 are then conducted, which demonstrate excellent agreement. Several sets of reference results for natural convection with volumetric heat generation in a bi-dimensional square cavity are also provided for future verification of numerical results obtained by other researchers.

  6. Integration of permanent magnet synchronous generator wind turbines into power grid

    Science.gov (United States)

    Abedini, Asghar

    , integrating energy storage systems with wind farms has attracted a lot of attention. These two subjects are addressed in this dissertation in detail. Permanent Magnet Synchronous Generators (PMSG) are used in variable speed wind turbines. In this thesis, the dynamic of the PMSG is investigated and a power electronic converter is designed to integrate the wind turbine to the grid. The risks of PMSG wind turbines such as low voltage ride through and short circuits, are assessed and the methods of mitigating the risks are discussed. In the second section of the thesis, various methods of smoothing wind turbine output power are explained and compared. Two novel methods of output power smoothing are analyzed: Rotor inertia and Super capacitors. The advantages and disadvantages of each method are explained and the dynamic model of each method is developed. The performance of the system is evaluated by simulating the wind turbine system in each method. The concepts of the methods of smoothing wind power can be implemented in other types of wind turbines such as Doubly Fed Induction Generator (DFIG) wind turbines.

  7. Defining and measuring integrated patient care: promoting the next frontier in health care delivery.

    NARCIS (Netherlands)

    Singer, S.J.; Burgers, J.S.; Friedberg, M.; Rosenthal, M.B.; Leape, L.; Schneider, E.

    2011-01-01

    Integration of care is emerging as a central challenge of health care delivery, particularly for patients with multiple, complex chronic conditions. The authors argue that the concept of "integrated patient care" would benefit from further clarification regarding (a) the object of integration and (b

  8. Defining and measuring integrated patient care: promoting the next frontier in health care delivery.

    NARCIS (Netherlands)

    Singer, S.J.; Burgers, J.S.; Friedberg, M.; Rosenthal, M.B.; Leape, L.; Schneider, E.

    2011-01-01

    Integration of care is emerging as a central challenge of health care delivery, particularly for patients with multiple, complex chronic conditions. The authors argue that the concept of "integrated patient care" would benefit from further clarification regarding (a) the object of integration and (b

  9. A process chain for integrating piezoelectric transducers into aluminum die castings to generate smart lightweight structures

    Science.gov (United States)

    Stein, Stefan; Wedler, Jonathan; Rhein, Sebastian; Schmidt, Michael; Körner, Carolin; Michaelis, Alexander; Gebhardt, Sylvia

    The application of piezoelectric transducers to structural body parts of machines or vehicles enables the combination of passive mechanical components with sensor and actuator functions in one single structure. According to Herold et al. [1] and Staeves [2] this approach indicates significant potential regarding smart lightweight construction. To obtain the highest yield, the piezoelectric transducers need to be integrated into the flux of forces (load path) of load bearing structures. Application in a downstream process reduces yield and process efficiency during manufacturing and operation, due to the necessity of a subsequent process step of sensor/actuator application. The die casting process offers the possibility for integration of piezoelectric transducers into metal structures. Aluminum castings are particularly favorable due to their high quality and feasibility for high unit production at low cost (Brunhuber [3], Nogowizin [4]). Such molded aluminum parts with integrated piezoelectric transducers enable functions like active vibration damping, structural health monitoring or energy harvesting resulting in significant possibilities of weight reduction, which is an increasingly important driving force of automotive and aerospace industry (Klein [5], Siebenpfeiffer [6]) due to increasingly stringent environmental protection laws. In the scope of those developments, this paper focuses on the entire process chain enabling the generation of lightweight metal structures with sensor and actuator function, starting from the manufacturing of piezoelectric modules over electrical and mechanical bonding to the integration of such modules into aluminum (Al) matrices by die casting. To achieve this challenging goal, piezoceramic sensors/actuator modules, so-called LTCC/PZT modules (LPM) were developed, since ceramic based piezoelectric modules are more likely to withstand the thermal stress of about 700 °C introduced by the casting process (Flössel et al., [7]). The

  10. Generating unique IDs from patient identification data using security models

    Directory of Open Access Journals (Sweden)

    Emad A Mohammed

    2016-01-01

    Full Text Available Background: The use of electronic health records (EHRs has continued to increase within healthcare systems in the developed and developing nations. EHRs allow for increased patient safety, grant patients easier access to their medical records, and offer a wealth of data to researchers. However, various bioethical, financial, logistical, and information security considerations must be addressed while transitioning to an EHR system. The need to encrypt private patient information for data sharing is one of the foremost challenges faced by health information technology. Method: We describe the usage of the message digest-5 (MD5 and secure hashing algorithm (SHA as methods for encrypting electronic medical data. In particular, we present an application of the MD5 and SHA-1 algorithms in encrypting a composite message from private patient information. Results: The results show that the composite message can be used to create a unique one-way encrypted ID per patient record that can be used for data sharing. Conclusion: The described software tool can be used to share patient EMRs between practitioners without revealing patients identifiable data.

  11. The management of dental patients taking new generation oral anticoagulants.

    Science.gov (United States)

    Scott, Alun; Gibson, John; Crighton, Alexander

    2014-11-01

    Recently, new oral anticoagulants have been introduced as alternatives to warfarin. While national guidelines for treatment of dental patients taking warfarin as an anticoagulant are well-established, no such information is available for these novel therapeutic agents. At present, the local guidance available is contradictory between different health boards/health planning units, and liaison with the medical practitioner managing the individual patient's anticoagulation is imperative if any invasive procedure is proposed. This paper examines the available evidence regarding these drugs and sets out proposals for clinical guidance of dental practitioners treating these patients in primary dental care.

  12. Novel bed integrated ventilation method for hospital patient rooms

    DEFF Research Database (Denmark)

    Bivolarova, Mariya Petrova; Melikov, Arsen Krikor; Kokora, Monika

    2014-01-01

    a mattress having a suction opening from which bio-effluents generated from human body are exhausted. Experiments were conducted in a full-scale two-bed hospital room mock-up, 4.7 x 5.3 x 2.6 m3 (W x L x H). Only one of the patients’ beds was equipped with the ventilated mattress. The room was air......This study presents a novel method for advanced ventilation of hospital wards leading to improved air quality at reduced ventilation rate. The idea is to evacuate the bio-effluents generated from patients’ body by local exhaustion before being spread in the room. This concept was realized by using...... conditioned via mixing total volume ventilation system supplying air through a ceiling mounted diffuser. All experiments were performed at room air temperature of 23ºC. A thermal manikin was used to simulate a polluting patient on the bed equipped with the ventilated mattress. Two heated dummies were used...

  13. Entanglement generation in periodically driven integrable systems: Dynamical phase transitions and steady state

    Science.gov (United States)

    Sen, Arnab; Nandy, Sourav; Sengupta, K.

    2016-12-01

    We study a class of periodically driven d -dimensional integrable models and show that after n drive cycles with frequency ω , pure states with non-area-law entanglement entropy Sn(l ) ˜lα (n ,ω ) are generated, where l is the linear dimension of the subsystem, and d -1 ≤α (n ,ω )≤d . The exponent α (n ,ω ) eventually approaches d (volume law) for large enough l when n →∞ . We identify and analyze the crossover phenomenon from an area (S ˜ld -1 for d ≥1 ) to a volume (S ˜ld ) law and provide a criterion for their occurrence which constitutes a generalization of Hastings's theorem to driven integrable systems in one dimension. We also find that Sn generically decays to S∞ as (ω/n ) (d +2 )/2 for fast and (ω/n ) d /2 for slow periodic drives; these two dynamical phases are separated by a topological transition in the eigenspectrum of the Floquet Hamiltonian. This dynamical transition manifests itself in the temporal behavior of all local correlation functions and does not require a critical point crossing during the drive. We find that these dynamical phases show a rich re-entrant behavior as a function of ω for d =1 models and also discuss the dynamical transition for d >1 models. Finally, we study entanglement properties of the steady state and show that singular features (cusps and kinks in d =1 ) appear in S∞ as a function of ω whenever there is a crossing of the Floquet bands. We discuss experiments which can test our theory.

  14. Analyzing Web 2.0 Integration with Next Generation Networks for Services Rendering

    Directory of Open Access Journals (Sweden)

    Kamaljit I. Lakhtaria

    2010-08-01

    Full Text Available The Next Generation Networks (NGN aims to integrate for IP-based telecominfrastructures and provide most advance & high speed emerging value added services.NGN capable to provide higher innovative services, these services will able to integratecommunication and Web service into a single platform. IP Multimedia Subsystem, aNGN leading technology, enables a variety of NGN-compliant communications servicesto interoperate while being accessed through different kinds of access networks,preferably broadband. IMS–NGN services essential by both consumer and corporateusers are by now used to access services, even communications services through the weband web-based communities and social networks, It is key for success of IMS-basedservices to be provided with efficient web access, so users can benefit from those newservices by using web-based applications and user interfaces, not only NGN-IMS UserEquipments and SIP protocol. Many Service are under planning which provided onlyunder convergence of IMS & Web 2.0. Convergence between Web 2.0 and NGN-IMScreates and serves new invented innovative, entertainment and information appealing aswell as user centric services and applications. These services merge features from WWWand Communication worlds. On the one hand, interactivity, ubiquity, social orientation,user participation and content generation, etc. are relevant characteristics coming fromWeb 2.0 services. Parallel IMS enables services including multimedia telephony, mediasharing (video-audio, instant messaging with presence and context, online directory,etc. all of them applicable to mobile, fixed or convergent telecom networks. With thispaper, this paper brings out the benefits of adopting web 2.0 technologies for telecomservices. As the services are today mainly driven by the user's needs, and proposed theconcept of unique customizable service interface.

  15. Integration of microarray technology into prenatal diagnosis: counselling issues generated during the NICHD clinical trial.

    Science.gov (United States)

    Wapner, Ronald J; Driscoll, Deborah A; Simpson, Joe Leigh

    2012-04-01

    Cytogenetic microarray analysis (CMA) in prenatal testing detects chromosome abnormalities and new genetic syndromes that would be missed by conventional cytogenetics and has the potential to significantly enhance prenatal genetic evaluation. A large Eunice Kennedy Shriver National Institute Of Child Health and Human Development (NICHD)-sponsored multicentered trial to assess the role of CMA as a primary prenatal diagnostic tool has been completed, and results will soon be available. Integration of this technology into clinical care will require thoughtful changes in patient counseling. Here, we examine four cases, all ascertained in the NICHD prenatal microarray study, to illustrate the challenges and subtleties of genetic counseling required with prenatal CMA testing. Although the specifics of each case are distinct, the underlying genetic principles of uncertainty, variable expressivity, and lack of precise genotype-phenotype correlation are well known and already part of prenatal counseling. Counselor and practitioner education will need to include both the science of interpreting array findings as well as development of improved approaches to uncertainty. A team approach to interpretation will need to be developed, as will standardized guidelines by professional organizations and laboratories. Of equal import is additional research into patient attitudes and desires, and a better understanding of the full phenotypic spectrum of copy number variants discovered in utero.

  16. Integration of a network aware traffic generation device into a computer network emulation platform

    CSIR Research Space (South Africa)

    Von Solms, S

    2014-07-01

    Full Text Available aware traffic into the network emulation platform. Traffic generators are often systems that replay captured traffic packet-by-packet or generate traffic according to a specified model or preconfigured sequence. Many of these traffic generators can...

  17. Peroxidase-Generated Apoplastic ROS Impair Cuticle Integrity and Contribute to DAMP-Elicited Defenses

    Science.gov (United States)

    Survila, Mantas; Davidsson, Pär R.; Pennanen, Ville; Kariola, Tarja; Broberg, Martin; Sipari, Nina; Heino, Pekka; Palva, Erkki T.

    2016-01-01

    Cuticular defects trigger a battery of reactions including enhanced reactive oxygen species (ROS) production and resistance to necrotrophic pathogens. However, the source of ROS generated by such impaired cuticles has remained elusive. Here, we report the characterization of Arabidopsis thaliana ohy1 mutant, a Peroxidase 57 (PER57) – overexpressing line that demonstrates enhanced defense responses that result both from increased accumulation of ROS and permeability of the leaf cuticle. The ohy1 mutant was identified in a screen of A. thaliana seedlings for oligogalacturonides (OGs) insensitive/hypersensitive mutants that exhibit altered growth retardation in response to exogenous OGs. Mutants impaired in OG sensitivity were analyzed for disease resistance/susceptibility to the necrotrophic phytopathogens Botrytis cinerea and Pectobacterium carotovorum. In the ohy1 line, the hypersensitivity to OGs was associated with resistance to the tested pathogens. This PER57 overexpressing line exhibited a significantly more permeable leaf cuticle than wild-type plants and this phenotype could be recapitulated by overexpressing other class III peroxidases. Such peroxidase overexpression was accompanied by the suppressed expression of cutin biosynthesis genes and the enhanced expression of genes associated with OG-signaling. Application of ABA completely removed ROS, restored the expression of genes associated with cuticle biosynthesis and led to decreased permeability of the leaf cuticle, and finally, abolished immunity to B. cinerea. Our work demonstrates that increased peroxidase activity increases permeability of the leaf cuticle. The loss of cuticle integrity primes plant defenses to necrotrophic pathogens via the activation of DAMP-responses. PMID:28066496

  18. A mathematical model for an integrated self priming dielectric elastomer generator

    Science.gov (United States)

    Illenberger, Patrin K.; Wilson, Katherine E.; Henke, E.-F. Markus; Madawala, Udaya K.; Anderson, Iain A.

    2017-04-01

    Dielectric Elastomer Generators (DEG) can capture energy from natural movement sources such as wind, the tides and human locomotion. The harvested energy can be used for low power devices such as wireless sensor nodes and wearable electronics. A challenge for low power DEG is overcoming the losses associated with charge management. A circuit which can do this exists: the Self Priming Circuit (SPC) which consists of diodes and capacitors. The SPC is connected in parallel to the DEG where it transfers charge onto/o_ the DEG based on changes in the DEG capacitance. Modelling and experimental validation of the SPC have been performed in the past, allowing design and implementation of effective SPCs which match a particular DEG. While the SPC is effective, it is still an external circuit which adds additional mass and cost to the DEG. By splitting the DEG into separate capacitors and using them to build an SPC, the Integrated SPC (I-SPC) can be realized. This reduces the components required to build a SPC/DEG and improves the performance. This paper presents a mathematical model with experimental data of a first order I-SPC. Additionally, comparisons between the SPC and I-SPC are drawn.

  19. Generation of Integration-free and Region-Specific Neural Progenitors from Primate Fibroblasts

    Directory of Open Access Journals (Sweden)

    Jianfeng Lu

    2013-05-01

    Full Text Available Postnatal and adult human and monkey fibroblasts were infected with Sendai virus containing the Yamanaka factors for 24 hr, then they were cultured in a chemically defined medium containing leukemia inhibitory factor (LIF, transforming growth factor (TGF-β inhibitor SB431542, and glycogen synthase kinase (GSK-3β inhibitor CHIR99021 at 39°C for inactivation of the virus. Induced neural progenitor (iNP colonies appeared as early as day 13 and can be expanded for >20 passages. Under the same defined condition, no induced pluripotent stem cell (iPSC colonies formed at either 37°C or 39°C. The iNPs predominantly express hindbrain genes and differentiate into hindbrain neurons, and when caudalized, they produced an enriched population of spinal motor neurons. Following transplantation into the forebrain, the iNP-derived cells retained the hindbrain identity. The ability to generate defined, integration-free iNPs from adult primate fibroblasts under a defined condition with predictable fate choices will facilitate disease modeling and therapeutic development.

  20. Energy Generation from Horse Husbandry Residues by Anaerobic Digestion, Combustion, and an Integrated Approach

    Directory of Open Access Journals (Sweden)

    Meike Nitsche

    2017-02-01

    Full Text Available Horse-related activities often occur close to urban areas, where acreage for horse manure disposal is scarce, and subsequently alternative recovery options are necessary. Anaerobic digestion, direct combustion, and the integrated generation of solid fuel and biogas from biomass (IFBB process are potential techniques focusing on energy provision. In this study, samples of horse faeces were analysed for chemical composition as pure feedstock and in mixture with straw or wood shavings, as well as for energy yield by biogas production or from combustion of solid fuel. It was observed that chemical properties of faeces, in a mixture with wood shavings, were promising for direct combustion, but achieved low methane yields. The methane yield of pure faeces and the straw mixture was 222.33 ± 13.60 and 233.01 ± 31.32 lN·kg-1 volatile solids (VSadded, respectively. The IFBB process divided the biomass into a press cake with reduced mineral concentration and a press fluid. Methane yields of press fluids were low (108.2 lN·kg-1 VSadded, on average. The chemical composition of the press cake allowed for combustion and led to a higher gross energy potential than anaerobic digestion (two-fold higher for pure manure and the mixture with straw, and five-fold higher for the mixture with shavings. Consequently, the gross energy potential of IFBB is higher compared to anaerobic digestion, however it should be noted that local conditions might favour the implementation of anaerobic digestion.

  1. Quality control of next-generation sequencing library through an integrative digital microfluidic platform.

    Science.gov (United States)

    Thaitrong, Numrin; Kim, Hanyoup; Renzi, Ronald F; Bartsch, Michael S; Meagher, Robert J; Patel, Kamlesh D

    2012-12-01

    We have developed an automated quality control (QC) platform for next-generation sequencing (NGS) library characterization by integrating a droplet-based digital microfluidic (DMF) system with a capillary-based reagent delivery unit and a quantitative CE module. Using an in-plane capillary-DMF interface, a prepared sample droplet was actuated into position between the ground electrode and the inlet of the separation capillary to complete the circuit for an electrokinetic injection. Using a DNA ladder as an internal standard, the CE module with a compact LIF detector was capable of detecting dsDNA in the range of 5-100 pg/μL, suitable for the amount of DNA required by the Illumina Genome Analyzer sequencing platform. This DMF-CE platform consumes tenfold less sample volume than the current Agilent BioAnalyzer QC technique, preserving precious sample while providing necessary sensitivity and accuracy for optimal sequencing performance. The ability of this microfluidic system to validate NGS library preparation was demonstrated by examining the effects of limited-cycle PCR amplification on the size distribution and the yield of Illumina-compatible libraries, demonstrating that as few as ten cycles of PCR bias the size distribution of the library toward undesirable larger fragments.

  2. Integrated process modeling for the laser inertial fusion Energy (LIFE) generation system

    Energy Technology Data Exchange (ETDEWEB)

    Meier, W R; Anklam, T M; Erlandson, A C; Miles, R R; Simon, A J; Sawicki, R; Storm, E

    2009-10-22

    A concept for a new fusion-fission hybrid technology is being developed at Lawrence Livermore National Laboratory. The primary application of this technology is base-load electrical power generation. However, variants of the baseline technology can be used to 'burn' spent nuclear fuel from light water reactors or to perform selective transmutation of problematic fission products. The use of a fusion driver allows very high burn-up of the fission fuel, limited only by the radiation resistance of the fuel form and system structures. As a part of this process, integrated process models have been developed to aid in concept definition. Several models have been developed. A cost scaling model allows quick assessment of design changes or technology improvements on cost of electricity. System design models are being used to better understand system interactions and to do design trade-off and optimization studies. Here we describe the different systems models and present systems analysis results. Different market entry strategies are discussed along with potential benefits to US energy security and nuclear waste disposal. Advanced technology options are evaluated and potential benefits from additional R&D targeted at the different options is quantified.

  3. Integrated process modeling for the laser inertial fusion energy (LIFE) generation system

    Science.gov (United States)

    Meier, W. R.; Anklam, T. M.; Erlandson, A. C.; Miles, R. R.; Simon, A. J.; Sawicki, R.; Storm, E.

    2010-08-01

    A concept for a new fusion-fission hybrid technology is being developed at Lawrence Livermore National Laboratory. The primary application of this technology is base-load electrical power generation. However, variants of the baseline technology can be used to "burn" spent nuclear fuel from light water reactors or to perform selective transmutation of problematic fission products. The use of a fusion driver allows very high burn-up of the fission fuel, limited only by the radiation resistance of the fuel form and system structures. As a part of this process, integrated process models have been developed to aid in concept definition. Several models have been developed. A cost scaling model allows quick assessment of design changes or technology improvements on cost of electricity. System design models are being used to better understand system interactions and to do design trade-off and optimization studies. Here we describe the different systems models and present systems analysis results. Different market entry strategies are discussed along with potential benefits to US energy security and nuclear waste disposal. Advanced technology options are evaluated and potential benefits from additional R&D targeted at the different options is quantified.

  4. Patient perceptions of integrated care: confused by the term, clear on the concept

    Directory of Open Access Journals (Sweden)

    Kara Odom Walker

    2013-03-01

    Full Text Available Purpose: Health care reform in the United States has introduced terms such as “the patient-centered medical home” and “integrated care” that are often unclear and unfamiliar to patients. This study explored patient experiences with the functional domains of integrated care. Theory and methods: Patients first wrote their definitions of integrated care and then participated in focus group discussions about their experiences with the health care system. Transcripts were analyzed for thematic content. Results: Forty-four patients participated in one of seven focus groups in San Francisco, CA in English and Spanish. Many patients were not clear about the meaning of the term integrated care. However, patients described experiences largely reflected in an existing conceptual model of integrated care and the importance of coordination within and across teams and with community resources, continuity and sharing of information, and patient engagement. Patients with high medical needs described the ubiquitous challenges they faced in experiencing coordinated care. Conclusions: Patients may not understand the term integrated care but are relatively clear on what the concept of integrated care entails and support its successful implementation. Patients and their families are at the center of integrated care, and health systems need to support and empower them to successfully navigate the medical neighborhood.

  5. Integration and religiosity among the Turkish second generation in Europe: A comparative analysis across four capital cities

    OpenAIRE

    Fleischmann, Fenella; Phalet, Karen

    2011-01-01

    Abstract Drawing on recent cross-national surveys of the Turkish second generation, we test hypotheses of secularization and of religious vitality for Muslim minorities in Europe. Secularization predicts an inverse relationship between structural integration and religiosity, such that the Turkish second generation would be less religious with higher levels of educational attainment and intermarriage. The religious vitality hypothesis predicts the maintenance of religion in the seco...

  6. Renewable energy integration into the Australian National Electricity Market: Characterising the energy value of wind and solar generation

    OpenAIRE

    Nicholas Boerema; Merlinde Kay; Iain MacGill

    2010-01-01

    This paper examines how key characteristics of the underlying wind and solar resources may impact on their energy value within the Australian National Electricity Market(NEM). Analysis has been performed for wind generation using half hour NEM data for South Australia over the 2008-9 financial year. The potential integration of large scale solar generation has been modelled using direct normal solar radiant energy measurements from the Bureau of Meteorology for six sites across the NEM. For w...

  7. Theoretical analysis of a collimated hollow-laser-beam generated by a single axicon using diffraction integral

    Institute of Scientific and Technical Information of China (English)

    Yong Qian(钱勇); Yuzhu Wang(王育竹)

    2004-01-01

    A novel method to generate a collimated hollow-laser-beam (HLB) by only a single axicon is proposed. With some reasonable assumptions, the radial light intensity distribution is calculated in detail by diffraction integral theory. The result of numerical simulation shows that this method is valid. Compared with other methods of generating HLB, this scheme is extraordinarily simple in principle and can be utilized experimentally to construct a light trap in atomic fountain for convenience.

  8. Generations.

    Science.gov (United States)

    Chambers, David W

    2005-01-01

    Groups naturally promote their strengths and prefer values and rules that give them an identity and an advantage. This shows up as generational tensions across cohorts who share common experiences, including common elders. Dramatic cultural events in America since 1925 can help create an understanding of the differing value structures of the Silents, the Boomers, Gen Xers, and the Millennials. Differences in how these generations see motivation and values, fundamental reality, relations with others, and work are presented, as are some applications of these differences to the dental profession.

  9. Generation and Characterization of Patient-Specific Induced Pluripotent Stem Cell for Disease Modeling.

    Science.gov (United States)

    Sivapatham, Renuka; Zeng, Xianmin

    2016-01-01

    One major hurdle to the development of effective treatments to many diseases is the lack of suitable human model systems. The ability to reprogram human somatic cells to induced pluripotent stem cells (iPSC) offers an excellent opportunity to generate human disease models with primary cells. Currently, several methods to generate iPSC lines exist, and iPSC can be generated from various tissue sources including skin fibroblasts, blood, hair follicles, dental tissue, and urine. In this chapter we describe the generation and characterization of iPSC from blood or fibroblast on a routine base and focus on the integration-free methodologies.

  10. Effects of treatment of peripheral pain generators in fibromyalgia patients.

    Science.gov (United States)

    Affaitati, Giannapia; Costantini, Raffaele; Fabrizio, Alessandra; Lapenna, Domenico; Tafuri, Emmanuele; Giamberardino, Maria Adele

    2011-01-01

    Fibromyalgia syndrome (FS) frequently co-occurs with regional pain disorders. This study evaluated how these disorders contribute to FS, by assessing effects of local active vs placebo treatment of muscle/joint pain sources on FS symptoms. Female patients with (1) FS+myofascial pain syndromes from trigger points (n=68), or (2) FS+joint pain (n=56) underwent evaluation of myofascial/joint symptoms [number/intensity of pain episodes, pressure pain thresholds at trigger/joint site, paracetamol consumption] and FS symptoms [pain intensity, pressure pain thresholds at tender points, pressure and electrical pain thresholds in skin, subcutis and muscle in a non-painful site]. Patients of both protocols were randomly assigned to two groups [34 each for (1); 28 each for (2)] to receive active or placebo local TrP or joint treatment [injection/hydroelectrophoresis] on days 1 and 4. Evaluations were repeated on days 4 and 8. After therapy, in active--but not placebo-treated-- groups: number and intensity of myofascial/joint episodes and paracetamol consumption decreased and pressure thresholds at trigger/joint increased (ppain intensity decreased and all thresholds increased progressively in tender points and the non-painful site (ppain was still lower than basis in patients not undergoing further therapy and had decreased in those undergoing active therapy from day 8 (ppains impact significantly on FS, probably through increased central sensitization by the peripheral input; their systematic identification and treatment are recommended in fibromyalgia.

  11. Use of picosecond optical pulses and FET's integrated with printed circuit antennas to generate millimeter wave radiation

    Science.gov (United States)

    Ni, D. C.; Plant, D. V.; Fetterman, H. R.; Matloubian, M.

    1991-03-01

    Millimeter-wave radiation has been generated from FETs and high electron mobility transistors (HEMTs), integrated with printed circuit antennas and illuminated with picosecond optical pulses. Modulation of the millimeter waves was achieved by applying a swept RF signal to the transistor gate. Using this technique, tunable electrical sidebands were added to the optically generated carrier providing a method of transmitting information. The technique also provides increased resolution for use in spectroscopic applications. Heterodyne detection demonstrated that the system continuously generated tunable radiation, constrained by the high-gain antenna, from 45 to 75 GHz.

  12. Integrating guideline development and implementation: analysis of guideline development manual instructions for generating implementation advice

    Directory of Open Access Journals (Sweden)

    Gagliardi Anna R

    2012-07-01

    Full Text Available Abstract Background Guidelines are important tools that inform healthcare delivery based on best available research evidence. Guideline use is in part based on quality of the guidelines, which includes advice for implementation and has been shown to vary. Others hypothesized this is due to limited instructions in guideline development manuals. The purpose of this study was to examine manual instructions for implementation advice. Methods We used a directed and summative content analysis approach based on an established framework of guideline implementability. Six manuals identified by another research group were examined to enumerate implementability domains and elements. Results Manuals were similar in content but lacked sufficient detail in particular domains. Most frequently this was Accomodation, which includes information that would help guideline users anticipate and/or overcome organizational and system level barriers. In more than one manual, information was also lacking for Communicability, information that would educate patients or facilitate their involvement in shared decision making, and Applicability, or clinical parameters to help clinicians tailor recommendations for individual patients. Discussion Most manuals that direct guideline development lack complete information about incorporating implementation advice. These findings can be used by those who developed the manuals to consider expanding their content in these domains. It can also be used by guideline developers as they plan the content and implementation of their guidelines so that the two are integrated. New approaches for guideline development and implementation may need to be developed. Use of guidelines might be improved if they included implementation advice, but this must be evaluated through ongoing research.

  13. Generational, Cultural, and Linguistic Integration for Literacy Learning and Teaching in Uganda: Pedagogical Possibilities, Challenges, and Lessons from One NGO

    Science.gov (United States)

    Ngaka, Willy; Graham, Ross; Masaazi, Fred Masagazi; Anyandru, Elly Moses

    2016-01-01

    This qualitative case study focuses on a volunteer-led local NGO in Uganda to examine how integrating generations, cultures, and languages is enhancing literacy learning to help ethnically and linguistically diverse rural communities survive in the prevailing globally competitive neoliberal environment. Immersing the study in the social practices…

  14. A performance analysis of integrated solid oxide fuel cell and heat recovery steam generator for IGFC system

    DEFF Research Database (Denmark)

    Rudra, Souman; Lee, Jinwook; Rosendahl, Lasse

    2010-01-01

    Solid oxide fuel cell (SOFC) is a promising technology for electricity generation. Sulfur-free syngas from a gas-cleaning unit serves as fuel for SOFC in integrated gasification fuel cell (IGFC) power plants. It converts the chemical energy of fuel gas directly into electric energy, thus high...

  15. Creating a YouTube-Like Collaborative Environment in Mathematics: Integrating Animated Geogebra Constructions and Student-Generated Screencast Videos

    Science.gov (United States)

    Lazarus, Jill; Roulet, Geoffrey

    2013-01-01

    This article discusses the integration of student-generated GeoGebra applets and Jing screencast videos to create a YouTube-like medium for sharing in mathematics. The value of combining dynamic mathematics software and screencast videos for facilitating communication and representations in a digital era is demonstrated herein. We share our…

  16. PCV 139 - Integrating patient preferences in efficiency frontier analyses using the analytical hierarchy process

    NARCIS (Netherlands)

    Hummel, J.M.; Steuten, L.; Til, van J.; IJzerman, M.

    2010-01-01

    OBJECTIVES: In comparative effectiveness research and economic evaluations, benefits of technologies are measured using multiple outcomes measures. Information lacks however about the importance of these endpoints for patients. We propose a new methodology to integrate patient weighted outcomes in a

  17. Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.A11

    DEFF Research Database (Denmark)

    Hansen, Susanne Kofoed; Borland, Helena; Hasholt, Lis Frydenreich;

    2016-01-01

    Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disease caused by a CAG-repeat expanding mutation in ATXN3. We generated induced pluripotent stem cells (iPSCs) from a SCA3 patient by electroporation of dermal fibroblasts with episomal plasmids encoding L-MYC, LIN28......, SOX2, KLF4, OCT4 and short hairpin RNA targeting P53. The resulting iPSCs had normal karyotype, were free of genomically integrated episomal plasmids, expressed pluripotency markers, could differentiate into the three germ layers in vitro and retained the disease-causing ATXN3 mutation. This iPSC line...

  18. Operational and Strategic Implementation of Dynamic Line Rating for Optimized Wind Energy Generation Integration

    Energy Technology Data Exchange (ETDEWEB)

    Gentle, Jake Paul [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-12-01

    One primary goal of rendering today’s transmission grid “smarter” is to optimize and better manage its power transfer capacity in real time. Power transfer capacity is affected by three main elements: stability, voltage limits, and thermal ratings. All three are critical, but thermal ratings represent the greatest opportunity to quickly, reliably and economically utilize the grid’s true capacity. With the “Smarter Grid”, new solutions have been sought to give operators a better grasp on real time conditions, allowing them to manage and extend the usefulness of existing transmission infrastructure in a safe and reliable manner. The objective of the INL Wind Program is to provide industry a Dynamic Line Rating (DLR) solution that is state of the art as measured by cost, accuracy and dependability, to enable human operators to make informed decisions and take appropriate actions without human or system overloading and impacting the reliability of the grid. In addition to mitigating transmission line congestion to better integrate wind, DLR also offers the opportunity to improve the grid with optimized utilization of transmission lines to relieve congestion in general. As wind-generated energy has become a bigger part of the nation’s energy portfolio, researchers have learned that wind not only turns turbine blades to generate electricity, but can cool transmission lines and increase transfer capabilities significantly, sometimes up to 60 percent. INL’s DLR development supports EERE and The Wind Energy Technology Office’s goals by informing system planners and grid operators of available transmission capacity, beyond typical Static Line Ratings (SLR). SLRs are based on a fixed set of conservative environmental conditions to establish a limit on the amount of current lines can safely carry without overheating. Using commercially available weather monitors mounted on industry informed custom brackets developed by INL in combination with Computational

  19. Integrated O&M for energy generation and exchange facilities; O&M integral para instalaciones de generación e intercambio de energía

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-07-01

    Ingeteam Service, part of the Ingeteam Group, is a leading company in the provision of integrated O&M services at energy generation and exchange facilities worldwide. From its head office in the Albacete Science and Technology Park, it manages the work of the 1,300 employees that make up its global workforce, rendering services to wind farms, PV installations and power generation plants. In addition, it maintains an active participation strategy in a range of R&D+i programmes that improve the existing technologies and are geared towards new production systems and new diagnostic techniques, applied to renewables installation maintenance. (Author)

  20. 1st or 2nd generation bioethanol-impacts of technology integration & on feed production and land use

    DEFF Research Database (Denmark)

    Bentsen, Niclas Scott; Felby, Claus

    2009-01-01

    with the poorest bio synthesis efficiency and as such the area demand for their production is relatively high. Preservation of the proteins in the biomass such as in feed by-products from bioethanol production is of paramount importance in developing sustainable utilisation of biomass in the energy sector......."1st or 2nd generation bioethanol-impacts of technology integration & on feed production and land use" Liquid bio fuels are perceived as a means of mitigating CO2 emissions from transport and thus climate change, but much concern has been raised to the energy consumption from refining biomass...... to liquid fuels. Integrating technologies such that waste stream can be used will reduce energy consumption in the production of bioethanol from wheat. We show that the integration of bio refining and combined heat an power generation reduces process energy requirements with 30-40 % and makes bioethanol...

  1. Neural injury alters proliferation and integration of adult-generated neurons in the dentate gyrus

    Science.gov (United States)

    Perederiy, Julia V.; Luikart, Bryan W.; Washburn, Eric K.; Schnell, Eric; Westbrook, Gary L.

    2013-01-01

    Neural plasticity following brain injury illustrates the potential for regeneration in the central nervous system. Lesioning of the perforant path, which innervates the outer 2/3rds of the molecular layer of the dentate gyrus, was one of the first models to demonstrate structural plasticity of mature granule cells (Parnavelas, 1974; Caceres and Steward, 1983; Diekmann et al., 1996). The dentate gyrus also harbors a continuously proliferating population of neuronal precursors that can integrate into functional circuits and show enhanced short-term plasticity (Schmidt-Hieber et al., 2004; Abrous et al., 2005). To examine the response of adult-generated granule cells to unilateral complete transection of the perforant path in vivo, we tracked these cells using transgenic POMC-EGFP mice or by retroviral expression of GFP. Lesioning triggered a marked proliferation of newborn neurons. Subsequently, the dendrites of newborn neurons showed reduced complexity within the denervated zone, but dendritic spines still formed in the absence of glutamatergic nerve terminals. Electron micrographs confirmed the lack of intact presynaptic terminals apposing spines on mature cells and on newborn neurons. Newborn neurons, but not mature granule cells, had a higher density of dendritic spines in the inner molecular layer post-lesion, accompanied by an increase in miniature EPSC amplitudes and rise times. Our results indicate that injury causes an increase in newborn neurons and lamina-specific synaptic reorganization, indicative of enhanced plasticity. The presence of de novo dendritic spines in the denervated zone suggests that the post-lesion environment provides the necessary signals for spine formation. PMID:23486947

  2. Development of ITM oxygen technology for integration in IGCC and other advanced power generation

    Energy Technology Data Exchange (ETDEWEB)

    Armstrong, Phillip A. [Air Products And Chemicals, Inc., Allentown, PA (United States)

    2015-03-31

    Ion Transport Membrane (ITM) technology is based on the oxygen-ion-conducting properties of certain mixed-metal oxide ceramic materials that can separate oxygen from an oxygen-containing gas, such as air, under a suitable driving force. The “ITM Oxygen” air separation system that results from the use of such ceramic membranes produces a hot, pure oxygen stream and a hot, pressurized, oxygen-depleted stream from which significant amounts of energy can be extracted. Accordingly, the technology integrates well with other high-temperature processes, including power generation. Air Products and Chemicals, Inc., the Recipient, in conjunction with a dozen subcontractors, developed ITM Oxygen technology under this five-phase Cooperative Agreement from the laboratory bench scale to implementation in a pilot plant capable of producing power and 100 tons per day (TPD) of purified oxygen. A commercial-scale membrane module manufacturing facility (the “CerFab”), sized to support a conceptual 2000 TPD ITM Oxygen Development Facility (ODF), was also established and operated under this Agreement. In the course of this work, the team developed prototype ceramic production processes and a robust planar ceramic membrane architecture based on a novel ceramic compound capable of high oxygen fluxes. The concept and feasibility of the technology was thoroughly established through laboratory pilot-scale operations testing commercial-scale membrane modules run under industrial operating conditions with compelling lifetime and reliability performance that supported further scale-up. Auxiliary systems, including contaminant mitigation, process controls, heat exchange, turbo-machinery, combustion, and membrane pressure vessels were extensively investigated and developed. The Recipient and subcontractors developed efficient process cycles that co-produce oxygen and power based on compact, low-cost ITMs. Process economics assessments show significant benefits relative to state

  3. Assessing patients’ experience of integrated care: a survey of patient views in the North West London Integrated Care Pilot

    Directory of Open Access Journals (Sweden)

    Nikolaos Mastellos

    2014-06-01

    Full Text Available Introduction: Despite the importance of continuity of care and patient engagement, few studies have captured patients’ views on integrated care. This study assesses patient experience in the Integrated Care Pilot in North West London with the aim to help clinicians and policy makers understand patients’ acceptability of integrated care and design future initiatives. Methods: A survey was developed, validated and distributed to 2029 randomly selected practice patients identified as having a care plan. Results: A total of 405 questionnaires were included for analysis. Respondents identified a number of benefits associated with the pilot, including increased patient involvement in decision-making, improved patient-provider relationship, better organisation and access to care, and enhanced inter-professional communication. However, only 22.4% were aware of having a care plan, and of these only 37.9% had a copy of the care plan. Knowledge of care plans was significantly associated with a more positive experience. Conclusions: This study reinforces the view that integrated care can improve quality of care and patient experience. However, care planning was a complex and technically challenging process that occurred more slowly than planned with wide variation in quality and time of recruitment to the pilot, making it difficult to assess the sustainability of benefits.

  4. Assessing patients’ experience of integrated care: a survey of patient views in the North West London Integrated Care Pilot

    Directory of Open Access Journals (Sweden)

    Nikolaos Mastellos

    2014-06-01

    Full Text Available Introduction: Despite the importance of continuity of care and patient engagement, few studies have captured patients’ views on integrated care. This study assesses patient experience in the Integrated Care Pilot in North West London with the aim to help clinicians and policy makers understand patients’ acceptability of integrated care and design future initiatives.Methods: A survey was developed, validated and distributed to 2029 randomly selected practice patients identified as having a care plan.Results: A total of 405 questionnaires were included for analysis. Respondents identified a number of benefits associated with the pilot, including increased patient involvement in decision-making, improved patient-provider relationship, better organisation and access to care, and enhanced inter-professional communication. However, only 22.4% were aware of having a care plan, and of these only 37.9% had a copy of the care plan. Knowledge of care plans was significantly associated with a more positive experience.Conclusions: This study reinforces the view that integrated care can improve quality of care and patient experience. However, care planning was a complex and technically challenging process that occurred more slowly than planned with wide variation in quality and time of recruitment to the pilot, making it difficult to assess the sustainability of benefits.

  5. Torque Distribution Characteristics of a Novel Double-Stator Permanent Magnet Generator Integrated with a Magnetic Gear

    Directory of Open Access Journals (Sweden)

    Shehu Salihu Mustafa

    2016-12-01

    Full Text Available This paper presents a novel double-stator permanent-magnet machine integrated with a triple rotor magnetic gear structure, which is proposed to address problems of mechanical geared generators for low-speed applications. Torque transmission is based on three rotors consisting of prime permanent-magnet (PM poles in the middle rotor and field PM poles in the inner and outer rotors. The proposed machine combines the functions of magnetic gearing and electrical power generation. The operating principles of the magnetic gear and generator are discussed and the torque distribution characteristics of the integrated machine are analysed using the 2D finite-element method (2D FEM. Also the power, torque, and speed characteristics are reported. A prototype is fabricated and tested experimentally. The predicted and measured results validate the proposed machine design.

  6. Steam generator collector integrity of WWER-1000 reactors. IAEA extrabudgetary programme on the safety of WWER NPPs

    Energy Technology Data Exchange (ETDEWEB)

    Lin, C.; Strupczewski, A. [International Atomic Energy Agency, Vienna (Austria)

    1995-12-31

    At the Consultants` Meeting on `The Safety of WWER-1000 Model 320 Nuclear Power Plants` organized by the IAEA within the framework of its Extrabudgetary Programme on the Safety of WWER-1000 NPPs, which was held in Vienna, 1-5 June 1992, the problem of WWER-1000 steam generator integrity was identified as an important issue of safety concern. Considering the safety importance of this issue, a Consultants` Meeting on `The Steam Generator Integrity of WWER-1000 Nuclear Power Plants` was convened in Vienna in May 1993, attended by 15 international experts in the area to compile information on the steam generator operating experience, deficiencies and corrective measures implemented and planned. In order to also include information from the main designer OKB Gidropress and to finalize the meeting report the IAEA convened a second meeting on the issue on 23-27 November 1993. The present paper summarizes the information and conclusions from those meetings.

  7. Power generation on a solar photovoltaic modules integrated Lighter-than-Air Platform at a low altitude

    CERN Document Server

    Ghosh, Kuntal; Duttagupta, Siddharth P

    2016-01-01

    Use of lighter than air platforms (aerostats and airships) for reconnaissance and surveillance over long periods can be facilitated by generation of power on-board through solar photovoltaic arrays. Attempts to integrate solar photovoltaic modules on such contoured surfaces leads to multiple challenges ranging from the choice of solar modules, determination of best method of their integration with the lighter than air platform, and design of the array layout in order to optimize the loss of power due to non-uniform illumination. This paper describes the method of designing such a system and suggests strategies for overcoming these challenges. The issue of non-uniform illumination has been tackled by maximum power point tracking using the scanning window technique for maximizing power generation and an algorithm of distributed maximum power point tracking has been suggested for further improvement. The procedure described in this paper can be used for obtaining the optimum power generation capability of a sola...

  8. Developing IntegRATE: a fast and frugal patient-reported measure of integration in health care delivery

    Directory of Open Access Journals (Sweden)

    Glyn Elwyn

    2015-03-01

    Full Text Available Background: Efforts have been made to measure integration in health care delivery, but few existing instruments have adopted a patient perspective, and none is sufficiently generic and brief for administration at scale. We sought to develop a brief and generic patient-reported measure of integration in health care delivery.Methods: Drawing on both existing conceptualisations of integrated care and research on patients’ perspectives, we chose to focus on four distinct domains of integration: information sharing,consistent advice, mutual respect and role clarity. We formulated candidate items and conducted cognitive interviews with end users to further develop and refine the items. We then pilot-tested the measure.Results: Four rounds of cognitive interviews were conducted (n = 14 and resulted in a four-item measure that was both relevant and understandable to end users. The pilot administration of the measure (n = 15 further confirmed the relevance and interpretability of items and demonstrated that the measure could be completed in less than one minute.Conclusions: This new measure, IntegRATE, represents a patient-reported measure of integration in health care delivery that is conducive to use in both routine performance monitoring and research. The psychometric properties of the measure will be assessed in the next stage of development. 

  9. Generation IV Reactors Integrated Materials Technology Program Plan: Focus on Very High Temperature Reactor Materials

    Energy Technology Data Exchange (ETDEWEB)

    Corwin, William R [ORNL; Burchell, Timothy D [ORNL; Katoh, Yutai [ORNL; McGreevy, Timothy E [ORNL; Nanstad, Randy K [ORNL; Ren, Weiju [ORNL; Snead, Lance Lewis [ORNL; Wilson, Dane F [ORNL

    2008-08-01

    Since 2002, the Department of Energy's (DOE's) Generation IV Nuclear Energy Systems (Gen IV) Program has addressed the research and development (R&D) necessary to support next-generation nuclear energy systems. The six most promising systems identified for next-generation nuclear energy are described within this roadmap. Two employ a thermal neutron spectrum with coolants and temperatures that enable hydrogen or electricity production with high efficiency (the Supercritical Water Reactor-SCWR and the Very High Temperature Reactor-VHTR). Three employ a fast neutron spectrum to enable more effective management of actinides through recycling of most components in the discharged fuel (the Gas-cooled Fast Reactor-GFR, the Lead-cooled Fast Reactor-LFR, and the Sodium-cooled Fast Reactor-SFR). The Molten Salt Reactor (MSR) employs a circulating liquid fuel mixture that offers considerable flexibility for recycling actinides and may provide an alternative to accelerator-driven systems. At the inception of DOE's Gen IV program, it was decided to significantly pursue five of the six concepts identified in the Gen IV roadmap to determine which of them was most appropriate to meet the needs of future U.S. nuclear power generation. In particular, evaluation of the highly efficient thermal SCWR and VHTR reactors was initiated primarily for energy production, and evaluation of the three fast reactor concepts, SFR, LFR, and GFR, was begun to assess viability for both energy production and their potential contribution to closing the fuel cycle. Within the Gen IV Program itself, only the VHTR class of reactors was selected for continued development. Hence, this document will address the multiple activities under the Gen IV program that contribute to the development of the VHTR. A few major technologies have been recognized by DOE as necessary to enable the deployment of the next generation of advanced nuclear reactors, including the development and qualification of

  10. Next-generation phage display: integrating and comparing available molecular tools to enable cost-effective high-throughput analysis.

    Directory of Open Access Journals (Sweden)

    Emmanuel Dias-Neto

    Full Text Available BACKGROUND: Combinatorial phage display has been used in the last 20 years in the identification of protein-ligands and protein-protein interactions, uncovering relevant molecular recognition events. Rate-limiting steps of combinatorial phage display library selection are (i the counting of transducing units and (ii the sequencing of the encoded displayed ligands. Here, we adapted emerging genomic technologies to minimize such challenges. METHODOLOGY/PRINCIPAL FINDINGS: We gained efficiency by applying in tandem real-time PCR for rapid quantification to enable bacteria-free phage display library screening, and added phage DNA next-generation sequencing for large-scale ligand analysis, reporting a fully integrated set of high-throughput quantitative and analytical tools. The approach is far less labor-intensive and allows rigorous quantification; for medical applications, including selections in patients, it also represents an advance for quantitative distribution analysis and ligand identification of hundreds of thousands of targeted particles from patient-derived biopsy or autopsy in a longer timeframe post library administration. Additional advantages over current methods include increased sensitivity, less variability, enhanced linearity, scalability, and accuracy at much lower cost. Sequences obtained by qPhage plus pyrosequencing were similar to a dataset produced from conventional Sanger-sequenced transducing-units (TU, with no biases due to GC content, codon usage, and amino acid or peptide frequency. These tools allow phage display selection and ligand analysis at >1,000-fold faster rate, and reduce costs approximately 250-fold for generating 10(6 ligand sequences. CONCLUSIONS/SIGNIFICANCE: Our analyses demonstrates that whereas this approach correlates with the traditional colony-counting, it is also capable of a much larger sampling, allowing a faster, less expensive, more accurate and consistent analysis of phage enrichment. Overall

  11. Low-Power, Rad-hard Reconfigurable, Bi-directional Flexfet? Level Shifter ReBiLS for Multiple Generation Technology Integration for Space Exploration Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The many different generations of integrated circuit (IC) technologies required for new space exploration systems demand designs operate at multiple and often...

  12. Patient empowerment in cancer pain management: an integrative literature review

    NARCIS (Netherlands)

    Boveldt, N.D. te; Vernooij-Dassen, M.; Leppink, I.; Samwel, H.; Vissers, K.; Engels, Y.M.

    2014-01-01

    OBJECTIVE: More than 50% of patients with cancer experience pain. Patient empowerment has been highlighted as central to success in pain management. Up to now, no clear model for this patient group exists, yet several strategies to empower patients have been used in clinical practice. This review ex

  13. Increasing infection rate in multiple implanted pulse generator changes in movement disorder patients treated with deep brain stimulation

    DEFF Research Database (Denmark)

    Thrane, Jens F; Sunde, Niels A; Bergholt, Bo

    2014-01-01

    Increasing infection rate in multiple implanted pulse generator changes in movement disorder patients treated with deep brain stimulation......Increasing infection rate in multiple implanted pulse generator changes in movement disorder patients treated with deep brain stimulation...

  14. Feasibility Analysis and Simulation of Integrated Renewable Energy System for Power Generation: A Hypothetical Study of Rural Health Clinic

    Directory of Open Access Journals (Sweden)

    Vincent Anayochukwu Ani

    2015-01-01

    Full Text Available This paper presents the feasibility analysis and study of integrated renewable energy (IRE using solar photovoltaic (PV and wind turbine (WT system in a hypothetical study of rural health clinic in Borno State, Nigeria. Electrical power consumption and metrology data (such as solar radiation and wind speed were used for designing and analyzing the integrated renewable energy system. The health clinic facility energy consumption is 19 kWh/day with a 3.4 kW peak demand load. The metrological data was collected from National Aeronautics and Space Administration (NASA website and used to analyze the performance of electrical generation system using HOMER program. The simulation and optimization results show that the optimal integrated renewable energy system configuration consists of 5 kW PV array, BWC Excel-R 7.5 kW DC wind turbine, 24 unit Surrette 6CS25P battery cycle charging, and a 19 kW AC/DC converter and that the PV power can generate electricity at 9,138 kWh/year while the wind turbine system can generate electricity at 7,490 kWh/year, giving the total electrical generation of the system as 16,628 kWh/year. This would be suitable for deployment of 100% clean energy for uninterruptable power performance in the health clinic. The economics analysis result found that the integrated renewable system has total NPC of 137,139 US Dollar. The results of this research show that, with a low energy health facility, it is possible to meet the entire annual energy demand of a health clinic solely through a stand-alone integrated renewable PV/wind energy supply.

  15. Simulation of integrated first and second generation bioethanol production from sugarcane: comparison between different biomass pretreatment methods.

    Science.gov (United States)

    Dias, Marina O S; da Cunha, Marcelo Pereira; Maciel Filho, Rubens; Bonomi, Antonio; Jesus, Charles D F; Rossell, Carlos E V

    2011-08-01

    Sugarcane bagasse is used as a fuel in conventional bioethanol production, providing heat and power for the plant; therefore, the amount of surplus bagasse available for use as raw material for second generation bioethanol production is related to the energy consumption of the bioethanol production process. Pentoses and lignin, byproducts of the second generation bioethanol production process, may be used as fuels, increasing the amount of surplus bagasse. In this work, simulations of the integrated bioethanol production process from sugarcane, surplus bagasse and trash were carried out. Selected pre-treatment methods followed, or not, by a delignification step were evaluated. The amount of lignocellulosic materials available for hydrolysis in each configuration was calculated assuming that 50% of sugarcane trash is recovered from the field. An economic risk analysis was carried out; the best results for the integrated first and second generation ethanol production process were obtained for steam explosion pretreatment, high solids loading for hydrolysis and 24-48 h hydrolysis. The second generation ethanol production process must be improved (e.g., decreasing required investment, improving yields and developing pentose fermentation to ethanol) in order for the integrated process to be more economically competitive.

  16. The Utrecht 850 kV cascade generator II. The beam integrator and galvanometer

    NARCIS (Netherlands)

    Smulders, P.J.M.; Smith, P.B.

    1960-01-01

    A current integrator is described for the integration of currents from 0.01 to 500 μA with an accuracy of 0.1%. The principle used is essentially the same as that of the excellent circuit described earlier by Helmer and Hemmendinger. The modifications effected result in a considerable reduction in e

  17. The effects of integration and generation of immigrants on language and numeracy achievement

    NARCIS (Netherlands)

    Driessen, G.; Merry, M.S.

    2011-01-01

    In many Western countries the pressure exerted on immigrants to integrate has become intense in recent years. Efforts to preserve their ethnic identity through multicultural recognition has now been replaced by the requirements of active civic participation and assimilation. Of course integration is

  18. Hierarchical predictive control scheme for distributed energy storage integrated with residential demand and photovoltaic generation

    NARCIS (Netherlands)

    Lampropoulos, I.; Garoufalis, P.; van den Bosch, P.P.J.; Kling, W.L.

    2015-01-01

    A hierarchical control scheme is defined for the energy management of a battery energy storage system which is integrated in a low-voltage distribution grid with residential customers and photovoltaic installations. The scope is the economic optimisation of the integrated system by employing predict

  19. Control, Co-generation, and Sensor Placement Strategy for Integral Small Modular Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Upadhyaya, Belle-R.; Fan, Li; Hines, J.-Wesley [University of Tennessee, Knoxville (United States); Perillo, Sergio-R. P. [Instituto de Pesquisas Energeticas e Nucleares, Sao Paulo (Brazil)

    2011-08-15

    The development of Small Modular Reactors (SMR) has multiple applications for electricity generation, process heat, hydrogen production, and others. The results of research, development, and demonstration (RD and D) of load-following control design for multiple modules, nuclear desalination, and sensor placement strategy for enhanced fault detection and isolation, are presented in this paper. The technologies are demonstrated with application to an integral pressurized water reactor (IPWR) such as the IRIS reactor. The outcomes of this RD and D include the development of a complete dynamic model of the IRIS system, load following control under dual-module steam mixing, nuclear desalination with a multi-stage flash (MSF) desalination plant, and automated technique for sensor allocation in a combined reactor and balance-of-plant system. The dynamic performance of a nuclear power station comprised of two IRIS reactor modules, operating simultaneously with a common steam header with steam mixing, was evaluated. The control problem addressed 'load-following' scenarios, such as varying load during the day or reduced consumption during the weekend. To solve this problem, a single-module IRIS MATLAB-Simulink model was developed and used to quantify the responses from both modules. The resulting model was subjected to eight different perturbation cases to analyze its capability of detecting small perturbations, therefore testing its robustness and sensitivity. The prospects of using nuclear energy for seawater desalination on a large scale can be very attractive since desalination is an energy intensive process that can utilize the heat from a nuclear reactor and/or the electricity produced by such plants. Small modular reactors, ranging from 50 MWe to 300 MWe, offer the largest potential as coupling options to nuclear desalination systems. However, coupling a nuclear plant and a desalination plant involves a number of issues that have to be addressed. Among these

  20. Esophageal acid sensitivity and mucosal integrity in patients with functional heartburn.

    Science.gov (United States)

    Weijenborg, P W; Smout, A J P M; Bredenoord, A J

    2016-11-01

    Patients with functional heartburn (FH) experience troublesome heartburn that is not related to gastroesophageal reflux. The etiology of the heartburn sensation in FH patients is unknown. In patients with reflux disease, esophageal hypersensitivity seems associated with impaired mucosal integrity. We aimed to determine esophageal sensitivity and mucosal integrity in FH and non-erosive reflux disease (NERD) patients. In this prospective experimental study, we performed an acid perfusion test and upper endoscopy with biopsies in 12 patients with NERD and nine patients with FH. Mucosal integrity was measured during endoscopy using electrical tissue impedance spectroscopy and biopsy specimens were analyzed in Ussing chambers for transepithelial electrical resistance and transepithelial permeability. Lag time to heartburn perception was significantly longer in FH patients (median 12 min) than in NERD patients (median 3 min). Once perceived, intensity of heartburn was scored equal with median visual analog scale 6.5 and 7.1 respectively. Esophageal mucosal integrity was also comparable between FH and NERD patients, both in vivo extracellular impedance and ex vivo transepithelial resistance and permeability were similar. Patients with FH did not show acid hypersensitivity as seen in patients with NERD. However, once perceived, intensity of heartburn is similar. Esophageal mucosal integrity is similar between NERD and FH patients, and is therefore unlikely to be the underlying cause of the observed difference in esophageal acid perception. © 2016 John Wiley & Sons Ltd.

  1. Patient-generated subjective global assessment : Innovation from paper to digital app

    NARCIS (Netherlands)

    Ottery, Faith D.; Isenring, Elizabeth; Kasenic, Suzanne; DeBolt, Susan P.; Sealy, Martine J.; Jager-Wittenaar, Harriet

    2015-01-01

    Purpose: The Patient-Generated Subjective Global Assessment (PG-SGA), including the PG-SGA Short Form (SF, aka ‘abridged’), was originally developed in the mid 1990’s as a scored, patient self-report, paperbased instrument and has been widely validated. The PG-SGA (SF) has been used for screening, a

  2. Comparative Study of on and off Grid Tied Integrated Diesel/Solar (PV) Battery Generation System

    OpenAIRE

    Okedu, Kenneth; Uhunmwangho, Roland; Bassey, Ngang

    2015-01-01

    This paper presents a proposed hybrid system based on diesel generator and solar photovoltaic (PV) as an effective option to power a small remote community. The cost of running diesel generator speedily due to erratic power supply in a small remote community that is not grid connected is highly expensive and not environmentally friendly. A solar PV was used to reduce or augment the continuous diesel generator sets, resulting in reduced cost of operation and maintenance. A proper solar radiati...

  3. Next generation sequencing on patients with LGMD and nonspecific myopathies: findings associated with ANO5 mutations

    OpenAIRE

    2015-01-01

    We studied 786 undiagnosed patients with LGMD or nonspecific myopathic features to investigate the role of ANO5 mutations in limb-girdle muscular dystrophies (LGMDs) and in nonspecific myopathies using the next generation sequencing (NGS) approach. In 160 LGMD patients, we first sequenced hotspot exons 5 and 20 and then sequenced the remaining part of the coding region. Another 626 patients, recruited using broader inclusion criteria, were directly analyzed by targeted NGS. By combining NGS a...

  4. Uncovering the decision-making work of transferring dying patients home from critical care units: An integrative review.

    Science.gov (United States)

    Lin, Yanxia; Myall, Michelle; Jarrett, Nikki

    2017-06-21

    To understand how decisions are made to transfer dying patients home from critical care units. Many people prefer a home death, but a high proportion die in critical care units. Transferring dying patients home is recognized to be complex but transfer decision-making itself remains unclear. Integrative review. Seven bibliographic databases (origin-2015), grey literature and reference lists were searched. An integrative review method was used to synthesize data from diverse sources. Papers were selected through title and abstract screening and full-text reviewing, using inclusion and exclusion criteria derived from review questions. Following quality appraisal, data were extracted and synthesized using normalization process theory as a framework. The number of patients transferred home ranged from 1-346, with most papers reporting on the transfer of one or two patients. Four themes regarding transfer decision-making work were generated: divergent views and practice, multiple stakeholders' involvement in decision-making, collective work and limited understanding of individuals' experiences. The practice of transferring patients home to die and its decision-making varies internationally and is usually influenced by the care system, culture or religion. It is less common to transfer patients home to die from critical care units in western societies. A better understanding of the decision-making work was obtained but mainly from the perspective of hospital-based healthcare professionals. Further research is needed to develop decision-making practice guidance to facilitate patients' wishes to die at home. © 2017 John Wiley & Sons Ltd.

  5. An integrative model of patient-centeredness - a systematic review and concept analysis.

    Directory of Open Access Journals (Sweden)

    Isabelle Scholl

    Full Text Available Existing models of patient-centeredness reveal a lack of conceptual clarity. This results in a heterogeneous use of the term, unclear measurement dimensions, inconsistent results regarding the effectiveness of patient-centered interventions, and finally in difficulties in implementing patient-centered care. The aim of this systematic review was to identify the different dimensions of patient-centeredness described in the literature and to propose an integrative model of patient-centeredness based on these results.Protocol driven search in five databases, combined with a comprehensive secondary search strategy. All articles that include a definition of patient-centeredness were eligible for inclusion in the review and subject to subsequent content analysis. Two researchers independently first screened titles and abstracts, then assessed full texts for eligibility. In each article the given definition of patient-centeredness was coded independently by two researchers. We discussed codes within the research team and condensed them into an integrative model of patient-centeredness.4707 records were identified through primary and secondary search, of which 706 were retained after screening of titles and abstracts. 417 articles (59% contained a definition of patient-centeredness and were coded. 15 dimensions of patient-centeredness were identified: essential characteristics of clinician, clinician-patient relationship, clinician-patient communication, patient as unique person, biopsychosocial perspective, patient information, patient involvement in care, involvement of family and friends, patient empowerment, physical support, emotional support, integration of medical and non-medical care, teamwork and teambuilding, access to care, coordination and continuity of care. In the resulting integrative model the dimensions were mapped onto different levels of care.The proposed integrative model of patient-centeredness allows different stakeholders to speak

  6. An Integrative Model of Patient-Centeredness – A Systematic Review and Concept Analysis

    Science.gov (United States)

    Scholl, Isabelle; Zill, Jördis M.; Härter, Martin; Dirmaier, Jörg

    2014-01-01

    Background Existing models of patient-centeredness reveal a lack of conceptual clarity. This results in a heterogeneous use of the term, unclear measurement dimensions, inconsistent results regarding the effectiveness of patient-centered interventions, and finally in difficulties in implementing patient-centered care. The aim of this systematic review was to identify the different dimensions of patient-centeredness described in the literature and to propose an integrative model of patient-centeredness based on these results. Methods Protocol driven search in five databases, combined with a comprehensive secondary search strategy. All articles that include a definition of patient-centeredness were eligible for inclusion in the review and subject to subsequent content analysis. Two researchers independently first screened titles and abstracts, then assessed full texts for eligibility. In each article the given definition of patient-centeredness was coded independently by two researchers. We discussed codes within the research team and condensed them into an integrative model of patient-centeredness. Results 4707 records were identified through primary and secondary search, of which 706 were retained after screening of titles and abstracts. 417 articles (59%) contained a definition of patient-centeredness and were coded. 15 dimensions of patient-centeredness were identified: essential characteristics of clinician, clinician-patient relationship, clinician-patient communication, patient as unique person, biopsychosocial perspective, patient information, patient involvement in care, involvement of family and friends, patient empowerment, physical support, emotional support, integration of medical and non-medical care, teamwork and teambuilding, access to care, coordination and continuity of care. In the resulting integrative model the dimensions were mapped onto different levels of care. Conclusions The proposed integrative model of patient-centeredness allows different

  7. MANAGEMENT OF SOLID WASTE GENERATED BY THE INTEGRATED STEELWORKS ACTIVITY AND SOLUTIONS TO REDUCE THE ENVIRONMENTAL IMPACT

    Directory of Open Access Journals (Sweden)

    Anişoara CIOCAN

    2010-05-01

    Full Text Available The development of steel industry is subject to solve major problems arising from industry-nature relationship, strictly targeted on pollution control and protection of natural resources and energy. In this paper we discussed about the management of solid waste generated by an integrated steelwork located near a major urban area and the adopted solutions for the reduction of environmental impact. There are summarized technical solutions that are currently applied and were proposed some solutions that can be applied in accordance with the environmental legislations. The new solutions are proposed for integrated management of solid wastes in accordance with: the exact quantification (quantitative, qualitative and the generation sources of emissions and solid wastes; controlled storage; minimization of the wastes and its harmfulness; transformation of the wastes into valuable by-products used directly by the company in a subsequent process, or by external down-stream user.

  8. Micro/nanofabricated solid-state thermoelectric generator devices for integrated high voltage power sources

    Science.gov (United States)

    Fleurial, J. P.; Snyder, G. J.; Patel, J.; Huang, C. K.; Ryan, M. A.; Averback, R.; Chen, G.; Hill, C.

    2002-01-01

    The Jet Propulsion Laboratory has been actively pursuing the development of thermoelectric micro/nanodevices that can be fabricated using a combination of electrochemical deposition and integrated circuit processing techniques.

  9. Integrated Planar Lightwave Circuits for UV Generation and Phase Modulation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The primary goal of this SBIR effort is delivery of a compact, robust, highly efficient, fiber-coupled UV module to provide the required 355nm light for integration...

  10. Micro/nanofabricated solid-state thermoelectric generator devices for integrated high voltage power sources

    Science.gov (United States)

    Fleurial, J. P.; Snyder, G. J.; Patel, J.; Huang, C. K.; Ryan, M. A.; Averback, R.; Chen, G.; Hill, C.

    2002-01-01

    The Jet Propulsion Laboratory has been actively pursuing the development of thermoelectric micro/nanodevices that can be fabricated using a combination of electrochemical deposition and integrated circuit processing techniques.

  11. Probabilistic Constrained Load Flow Considering Integration of Wind Power Generation and Electric Vehicles

    DEFF Research Database (Denmark)

    Vlachogiannis, Ioannis (John)

    2009-01-01

    A new formulation and solution of probabilistic constrained load flow (PCLF) problem suitable for modern power systems with wind power generation and electric vehicles (EV) demand or supply is represented. The developed stochastic model of EV demand/supply and the wind power generation model...

  12. Integration of humanoid robots in collaborative working environment: a case study on motion generation

    OpenAIRE

    Stasse, Olivier; Ruland, Rudolf; Lamiraux, Florent; Kheddar, Abderrahmane; Yokoi, Kazuhito; Prinz, Wolfgang

    2009-01-01

    International audience; This paper illustrates through a practical example an integration of a humanoid robotic architecture, with an open-platform collaborative working environment called BSCW (Be Smart-Cooperate Worldwide). BSCW is primarily designed to advocate a futuristic shared workspace system for humans. We exemplify how a complex robotic system (such as a humanoid robot) can be integrated as a proactive collaborative agent which provides services and interacts with other agents shari...

  13. French Regulatory practice and experience feedback on steam generator tube integrity

    Energy Technology Data Exchange (ETDEWEB)

    Sandon, G.

    1997-02-01

    This paper summarizes the way the French Safety Authority applies regulatory rules and practices to the problem of steam generator tube cracking in French PWR reactors. There are 54 reactors providing 80% of French electrical consumption. The Safety Authority closely monitors the performance of tubes in steam generators, and requires application of a program which deals with problems prior to the actual development of leakage. The actual rules regarding such performance are flexible, responding to the overall performance of operating steam generators. In addition there is an inservice inspection service to examine tubes during shutdown, and to monitor steam generators for leakage during operation, with guidelines for when generators must be pulled off line.

  14. A Multi-Agent System Based Protection and Control Scheme for Distribution System with Distributed Generation Integration

    DEFF Research Database (Denmark)

    Liu, Z.; Su, Chi; Hoidalen, Hans

    2017-01-01

    In this paper, a multi agent system (MAS) based protection and control scheme is proposed to deal with diverse operation conditions in distribution system due to distributed generation (DG) integration. Based on cooperation between DG controller and relays, an adaptive protection and control...... of system topology and DG status. The proposed scheme is tested and validated on a test distribution system in a hardware-in-the-loop real time testing platform....

  15. Implications of integrating electricity supply dynamics into life cycle assessment: a case study of renewable distributed generation

    OpenAIRE

    2014-01-01

    Electricity supply is frequently cited as a significant hot spot in life cycle assessment (LCA) results. Despite its importance, however, LCA research continues to overuse simplified methodologies regarding electricity supply modeling. This work aims to demonstrate the usefulness of electricity trade analysis (proposed model) for integrating the short-term dynamics of electricity supply and refining LCA results. Distributed generation using renewable energy is applied as a case study to demon...

  16. Integrated Simulation Development and Decision Support Tool-Set for Utility Market and Distributed Solar Power Generation Electricore, Inc.

    Energy Technology Data Exchange (ETDEWEB)

    Daye, Tony [Green Power Labs (GPL), San Diego, CA (United States)

    2013-09-30

    This project will enable utilities to develop long-term strategic plans that integrate high levels of renewable energy generation, and to better plan power system operations under high renewable penetration. The program developed forecast data streams for decision support and effective integration of centralized and distributed solar power generation in utility operations. This toolset focused on real time simulation of distributed power generation within utility grids with the emphasis on potential applications in day ahead (market) and real time (reliability) utility operations. The project team developed and demonstrated methodologies for quantifying the impact of distributed solar generation on core utility operations, identified protocols for internal data communication requirements, and worked with utility personnel to adapt the new distributed generation (DG) forecasts seamlessly within existing Load and Generation procedures through a sophisticated DMS. This project supported the objectives of the SunShot Initiative and SUNRISE by enabling core utility operations to enhance their simulation capability to analyze and prepare for the impacts of high penetrations of solar on the power grid. The impact of high penetration solar PV on utility operations is not only limited to control centers, but across many core operations. Benefits of an enhanced DMS using state-of-the-art solar forecast data were demonstrated within this project and have had an immediate direct operational cost savings for Energy Marketing for Day Ahead generation commitments, Real Time Operations, Load Forecasting (at an aggregate system level for Day Ahead), Demand Response, Long term Planning (asset management), Distribution Operations, and core ancillary services as required for balancing and reliability. This provided power system operators with the necessary tools and processes to operate the grid in a reliable manner under high renewable penetration.

  17. From colleague to patient: ethical challenges in integrated primary care.

    Science.gov (United States)

    Kanzler, Kathryn E; Goodie, Jeffrey L; Hunter, Christopher L; Glotfelter, Michael Ann; Bodart, Jennifer J

    2013-03-01

    Ethical codes and guidelines for mental health professionals focus on traditional avenues of practice, leaving considerable gaps for clinicians in unique settings, such as behavioral health providers in integrated primary care. In this article, an ethical scenario is presented, where a behavioral health provider is faced with a colleague physician seeking assistance for emotional distress. The scenario highlights important ethical questions about multiple relationships/conflict of interest, impaired colleagues, informed consent, and confidentiality. We review gaps in ethical guidance pertinent to the scenario and provide an eight-step rubric for ethical clinical decision making in integrated primary care.

  18. Thrombin generation and procoagulant phospholipids in patients with essential thrombocythemia and reactive thrombocytosis.

    Science.gov (United States)

    Mignon, I; Grand, F; Boyer, F; Hunault-Berger, M; Hamel, J F; Macchi, L

    2013-12-01

    Thrombocytosis is a commonly encountered clinical scenario and can be either a secondary process (reactive thrombocytosis), or due to clonal disorder (i.e., essential thrombocythemia). This distinction is important as it carries implications for evaluation, prognosis and treatment. In this study we compared procoagulant potential in essential thrombocythemia and reactive thrombocytosis by measuring the thrombin generation and the level of circulating procoagulant phospholipids with functional tests. Twenty nine patients with essential thrombocythemia and 24 with reactive thrombocytosis were studied. Thrombin generation was determined by calibrated automated thrombography. Procoagulant phospholipids were detected by a chronometric standardised method (STA-Procoag-PPL). Patients with reactive thrombocytosis had a longer lag time, higher endogenous thrombin potential, peak of thrombin generation and velocity index than patients with essential thrombocythemia. The level of circulating procoagulant phospholipids was increased in patients with essential thrombocythemia as observed with the procoagulant phospholipids assay. Each parameter was analysed using ROC curves. Highest areas under the curve (AUC) were found for lag time and procoagulant phospholipids ratio (0.817 and 0.853, respectively), associated with high negative predictive value for ET (92.3% and 80%, respectively). In conclusion, patients with essential thrombocythemia and reactive thrombocytosis displayed significant differences in terms of thrombin generation and levels of procoagulant phospholipids. Among these parameters, lag time and procoagulant phospholipids ratio could help to differentiate between reactive thrombocytosis and essential thrombocythemia patients.

  19. On the integration of wind generators on weak grids and island grids; Sur l'integration des generateurs eoliens dans les reseaux faibles ou insulaires

    Energy Technology Data Exchange (ETDEWEB)

    Laverdure, N

    2005-12-15

    Wind energy is now an energy that can not be ignored. Because of intrinsic characteristics (scattered primary energy, generators with different technologies, use of power electronics interface), wind energy system integration in distribution grids leads to real problems in terms of impacts. With recent standard changes, it is necessary to study the possibilities of each technology of wind turbines to answer or not to these new constraints. This PhD thesis focuses on a comparison of the main present wind turbines concerning three points of discussion: energy quality, fault ride through, ancillary services (voltage and frequency). It insists on the possibilities in terms of control laws for variable speed wind turbines. (author)

  20. Evaluation of the Effect of Operating Parameters on Thermal Performance of an Integrated Starter Generator in Hybrid Electric Vehicles

    Directory of Open Access Journals (Sweden)

    Moo-Yeon Lee

    2015-08-01

    Full Text Available The belt-driven-type integrated starter generator motor in a hybrid electric vehicle is vulnerable to thermal problems owing to its high output power and proximity to the engine. These problems may cause demagnetization and insulation breakdown, reducing the performance and durability of the motor. Hence, it is necessary to evaluate the thermal performance and enhance the cooling capacity of the belt-driven type Integrated Starter Generator. In this study, the internal temperature variations of the motor were investigated with respect to the operating parameters, particularly the rotation speed and environment temperature. At a maximum ambient temperature of 105 °C and rotation speed (motor design point of 4500 rpm, the coil of the motor was heated to approximately 189 °C in generating mode. The harsh conditions of the starting mode were analyzed by assuming that the motor operates during the start-up time at a maximum ambient temperature of 105 °C and rotation speed (motor design point of 800 rpm; the coil was heated to approximately 200 °C, which is close to the insulation temperature limit. The model for analyzing the thermal performance of the ISG was verified by comparing its results with those obtained through a generating-mode-based experiment

  1. An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells.

    Science.gov (United States)

    Okita, Keisuke; Yamakawa, Tatsuya; Matsumura, Yasuko; Sato, Yoshiko; Amano, Naoki; Watanabe, Akira; Goshima, Naoki; Yamanaka, Shinya

    2013-03-01

    The generation of induced pluripotent stem cells (iPSCs) provides the opportunity to use patient-specific somatic cells, which are a valuable source for disease modeling and drug discovery. To promote research involving these cells, it is important to make iPSCs from easily accessible and less invasive tissues, like blood. We have recently reported the efficient generation of human iPSCs from adult fibroblasts using a combination of plasmids encoding OCT3/4, SOX2, KLF4, L-MYC, LIN28, and shRNA for TP53. We herein report a modified protocol enabling efficient iPSC induction from CD34+ cord blood cells and from peripheral blood isolated from healthy donors using these plasmid vectors. The original plasmid mixture could induce iPSCs; however, the efficiency was low. The addition of EBNA1, an essential factor for episomal amplification of the vectors, by an extra plasmid greatly increased the efficiency of iPSC induction, especially when the induction was performed from αβT cells. This improvement enabled the establishment of blood-derived iPSCs from seven healthy donors ranging in age from their 20s to their 60s. This induction method will be useful for the derivation of patient-specific integration-free iPSCs and would also be applicable to the generation of clinical-grade iPSCs in the future.

  2. Emissions & Generation Resource Integrated Database (eGRID), eGRID2010

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Emissions emissions rates; net generation; resource mix; and many other attributes. eGRID2010 contains the complete release of year 2007 data, as well as years...

  3. Emissions & Generation Resource Integrated Database (eGRID), eGRID2012

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Emissions emissions rates; net generation; resource mix; and many other attributes. eGRID2012 Version 1.0 is the eighth edition of eGRID, which contains the...

  4. Multi Agent System Based Adaptive Protection for Dispersed Generation Integrated Distribution Systems

    DEFF Research Database (Denmark)

    Liu, Leo; Rather, Zakir Hussain; Bak, Claus Leth

    2013-01-01

    The increasing penetration of dispersed generation (DG) brings challenges to conventional protection approaches of distribution system, mainly due to bi-directional power flow and variable fault current contribution from different generation technology-based DG units. Moreover, the trend of allow......The increasing penetration of dispersed generation (DG) brings challenges to conventional protection approaches of distribution system, mainly due to bi-directional power flow and variable fault current contribution from different generation technology-based DG units. Moreover, the trend......) is proposed. The adaptive protection intelligently adopts suitable settings for the variation of fault current from diversified DG units. Furthermore, the structure of mobile MAS with additional flexibility is capable of adapting the changes of system topology in a short period, e.g. radial/meshed, grid...

  5. Achieving End-to-End QoS in the Next Generation Internet: Integrated Services over Differentiated Service Networks

    Science.gov (United States)

    Bai, Haowei; Atiquzzaman, Mohammed; Ivancic, William

    2001-01-01

    Currently there are two approaches to provide Quality of Service (QoS) in the next generation Internet: An early one is the Integrated Services (IntServ) with the goal of allowing end-to-end QoS to be provided to applications; the other one is the Differentiated Services (DiffServ) architecture providing QoS in the backbone. In this context, a DiffServ network may be viewed as a network element in the total end-to-end path. The objective of this paper is to investigate the possibility of providing end-to-end QoS when IntServ runs over DiffServ backbone in the next generation Internet. Our results show that the QoS requirements of IntServ applications can be successfully achieved when IntServ traffic is mapped to the DiffServ domain in next generation Internet.

  6. Integration of bio-fired gas turbines in combined heat and power generation; Integrering av biogaseldad gasturbin i kraftvaermeanlaeggning

    Energy Technology Data Exchange (ETDEWEB)

    Genrup, Magnus; Jonshagen, Klas

    2011-01-15

    The aim of the project was to perform a pre-study of the potential to introduce a biofired gas turbine into the pre-heater train of a district heating plant. The incentive for the work is the desire (and political drivers) to increase bio-fuel usage in heat and power production. Sweden has also ratified the EU treaty of having 20 percent renewable in the system before 2020. There are several options at the hand but locally produced biofuels from either gasification or biological processes can be fired in a gas turbine. The size of the gas turbine is limited by shear size of the fuel plant and raw-material transport issues. Today, the maximum electrical efficiency for large-scale advanced plants is on the order of 60 percent. This level is, however, not feasible for smaller size units and one can expect much lower levels. Another possibility is to re-power an existing plant and use the exhaust heat from the gas turbine. Either to produce steam in a heat recovery steam generator, heat boiler combustion air (and variants) or to reduce pre-heater extraction through by-passing the pre-heaters. Previous studies have shown that one could expect very high efficiency levels if the heat could be utilized in the feed water to the boiler. This is typically coupled to the admission pressure level and super-critical plant may have feed water temperature exceeding 300 deg C. The aim of this project was to investigate the potential from introducing this technology into a certain typical Swedish/Nordic turbine based district heating plant. A typical plant has modest admission data (compared to an ultra super-critical plant), hence lower final feed water temperature. A lower final temperature makes it more troublesome to effectively use the exhaust heat from the gas turbine. A further improvement is possible by introducing reheat. There are several practical limitations, where the most severe is the need to extract the full turbine flow and induce it after the reheater. The only

  7. A randomised multicentre trial of integrated versus standard treatment for patients with a first episode of psychotic illness

    DEFF Research Database (Denmark)

    Petersen, Lone Bente; Jeppesen, Pia; Thorup, Anne;

    2005-01-01

    To evaluate the effects of integrated treatment for patients with a first episode of psychotic illness.......To evaluate the effects of integrated treatment for patients with a first episode of psychotic illness....

  8. In-plane emission of indistinguishable photons generated by an integrated quantum emitter

    CERN Document Server

    Kalliakos, Sokratis; Schwagmann, Andre; Bennett, Anthony J; Ward, Martin B; Ellis, David J P; Skiba-Szymanska, Joanna; Farrer, Ian; Griffiths, Jonathan P; Jones, Geb A C; Ritchie, David A; Shields, Andrew J

    2014-01-01

    We demonstrate the emission of indistinguishable photons along a semiconductor chip originating from carrier recombination in an InAs quantum dot. The emitter is integrated in the waveguiding region of a photonic crystal structure, allowing for on-chip light propagation. We perform a Hong-Ou-Mandel-type of experiment with photons collected from the exit of the waveguide and we observe two-photon interference under continuous wave excitation. Our results pave the way for the integration of quantum emitters in advanced photonic quantum circuits.

  9. Indomethacin augments lymphokine-activated killer cell generation by patients with malignant mesothelioma

    Energy Technology Data Exchange (ETDEWEB)

    Manning, L.S.; Bowman, R.V.; Davis, M.R.; Musk, A.W.; Robinson, B.W. (Queen Elizabeth II Medical Centre, Nedlands (Australia))

    1989-10-01

    Human malignant mesothelioma (MM) cells are resistant to natural killer (NK) cell lysis but susceptible to lysis by lymphokine-activated killer (LAK) cells from control individuals. The present study was performed to determine the capacity of patients with MM (n = 22) and individuals occupationally exposed to asbestos (the major population at risk of developing this disease, n = 52) to generate LAK cells capable of effectively lysing human mesothelioma cells. Compared to controls (n = 20), both patient groups demonstrated significantly depressed LAK cell activity against mesothelioma tumor cell targets (55 +/- 3% lysis by controls vs 34 +/- 3% lysis by patients with MM, P less than 0.005; and 45 +/- 3% lysis by asbestos-exposed individuals, P less than 0.025). Addition of 10 micrograms/ml indomethacin during LAK cell generation restored normal LAK cell activity for patients with MM (52 +/- 6% lysis of cultured human MM cells, P = NS compared to controls), suggesting that the defective cytolytic cell function observed in some patients with MM is a result of prostaglandin-induced immunosuppression. The ability of indomethacin to restore suppressed LAK cell activity in patients with MM suggests that the concomitant use of this agent in ex vivo LAK cell generation and in patients undergoing interleukin/LAK cell therapy may be beneficial.

  10. Updated Generation IV Reactors Integrated Materials Technology Program Plan, Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Corwin, William R [ORNL; Burchell, Timothy D [ORNL; Halsey, William [Lawrence Livermore National Laboratory (LLNL); Hayner, George [Idaho National Laboratory (INL); Katoh, Yutai [ORNL; Klett, James William [ORNL; McGreevy, Timothy E [ORNL; Nanstad, Randy K [ORNL; Ren, Weiju [ORNL; Snead, Lance Lewis [ORNL; Stoller, Roger E [ORNL; Wilson, Dane F [ORNL

    2005-12-01

    The Department of Energy's (DOE's) Generation IV Nuclear Energy Systems Program will address the research and development (R&D) necessary to support next-generation nuclear energy systems. Such R&D will be guided by the technology roadmap developed for the Generation IV International Forum (GIF) over two years with the participation of over 100 experts from the GIF countries. The roadmap evaluated over 100 future systems proposed by researchers around the world. The scope of the R&D described in the roadmap covers the six most promising Generation IV systems. The effort ended in December 2002 with the issue of the final Generation IV Technology Roadmap [1.1]. The six most promising systems identified for next generation nuclear energy are described within the roadmap. Two employ a thermal neutron spectrum with coolants and temperatures that enable hydrogen or electricity production with high efficiency (the Supercritical Water Reactor - SCWR and the Very High Temperature Reactor - VHTR). Three employ a fast neutron spectrum to enable more effective management of actinides through recycling of most components in the discharged fuel (the Gas-cooled Fast Reactor - GFR, the Lead-cooled Fast Reactor - LFR, and the Sodium-cooled Fast Reactor - SFR). The Molten Salt Reactor (MSR) employs a circulating liquid fuel mixture that offers considerable flexibility for recycling actinides, and may provide an alternative to accelerator-driven systems. A few major technologies have been recognized by DOE as necessary to enable the deployment of the next generation of advanced nuclear reactors, including the development and qualification of the structural materials needed to ensure their safe and reliable operation. Accordingly, DOE has identified materials as one of the focus areas for Gen IV technology development.

  11. Biochemistry of the Envenomation Response--A Generator Theme for Interdisciplinary Integration

    Science.gov (United States)

    Montagna, Erik; Guerreiro, Juliano R.; Torres, Bayardo B.

    2010-01-01

    The understanding of complex physiological processes requires information from many different areas of knowledge. To meet this interdisciplinary scenario, the ability of integrating and articulating information is demanded. The difficulty of such approach arises because, more often than not, information is fragmented through under graduation…

  12. Electricity generation by a plant microbial fuel cell with an integrated oxygen reducing biocathode

    NARCIS (Netherlands)

    Wetser, K.; Sudirjo, E.; Buisman, C.J.N.; Strik, D.P.B.T.B.

    2015-01-01

    In this study we show that a chemical ferricyanide cathode can be replaced by a biological oxygen reducing cathode in a plant microbial fuel cell (PMFC) with a new record power output. A biocathode was successfully integrated in a PMFC and operated for 151 days. Plants growth continued and the power

  13. Generating Alternative Engineering Designs by Integrating Desktop VR with Genetic Algorithms

    Science.gov (United States)

    Chandramouli, Magesh; Bertoline, Gary; Connolly, Patrick

    2009-01-01

    This study proposes an innovative solution to the problem of multiobjective engineering design optimization by integrating desktop VR with genetic computing. Although, this study considers the case of construction design as an example to illustrate the framework, this method can very much be extended to other engineering design problems as well.…

  14. Dynamic surface tension measured with an integrated sensor-actuator using electrolytically generated gas bubbles

    NARCIS (Netherlands)

    Olthuis, Wouter; Volanschi, Alex; Bergveld, Piet

    1998-01-01

    In this paper, a new, simple method to determine dynamic surface tension in aqueous solutions is reported, explained and experimentally verified. By function integration, a small device is obtained. Apart from control and interface electronics no external components or systems are necessary. Instead

  15. Dynamic surface tension measured with an integrated sensor-actuator device using electrolytically generated gas bubbles

    NARCIS (Netherlands)

    Olthuis, Wouter; Volanschi, Alex; Bergveld, Piet

    1997-01-01

    In this paper, a new, simple method to determine dynamic surface tension in aqueous solutions is reported, explained and experimentally verified. By function integration, a small device is obtained; apart from control and interface electronics no external components or systems are necessary. Instead

  16. Generating Alternative Engineering Designs by Integrating Desktop VR with Genetic Algorithms

    Science.gov (United States)

    Chandramouli, Magesh; Bertoline, Gary; Connolly, Patrick

    2009-01-01

    This study proposes an innovative solution to the problem of multiobjective engineering design optimization by integrating desktop VR with genetic computing. Although, this study considers the case of construction design as an example to illustrate the framework, this method can very much be extended to other engineering design problems as well.…

  17. Integration of process and solvent design towards a novel generation of CO2 absorption capture systems

    NARCIS (Netherlands)

    Oyarzun, B.A.; Bardow, A.; Gross, J.

    2011-01-01

    A method for the integrated process and solvent design of absorption separation systems is proposed in this work. The method is employed here to improve the energetic performance of a pre-combustion CO2 absorption capture process by simultaneous optimization of process and solvent variables. In the

  18. Integration of first and second generation biofuels: Fermentative hydrogen production from wheat grain and straw

    NARCIS (Netherlands)

    Panagiotopoulos, I.A.; Bakker, R.R.C.; Vrije, de G.J.; Claassen, P.A.M.; Koukios, E.G.

    2013-01-01

    Integrating of lignocellulose-based and starch-rich biomass-based hydrogen production was investigated by mixing wheat straw hydrolysate with a wheat grain hydrolysate for improved fermentation. Enzymatic pretreatment and hydrolysis of wheat grains led to a hydrolysate with a sugar concentration of

  19. Ex vivo generation of dendritic cells from cryopreserved, post-induction chemotherapy, mobilized leukapheresis from pediatric patients with medulloblastoma.

    Science.gov (United States)

    Nair, Smita K; Driscoll, Timothy; Boczkowski, David; Schmittling, Robert; Reynolds, Renee; Johnson, Laura A; Grant, Gerald; Fuchs, Herbert; Bigner, Darell D; Sampson, John H; Gururangan, Sridharan; Mitchell, Duane A

    2015-10-01

    Generation of patient-derived, autologous dendritic cells (DCs) is a critical component of cancer immunotherapy with ex vivo-generated, tumor antigen-loaded DCs. An important factor in the ability to generate DCs is the potential impact of prior therapies on DC phenotype and function. We investigated the ability to generate DCs using cells harvested from pediatric patients with medulloblastoma for potential evaluation of DC-RNA based vaccination approach in this patient population. Cells harvested from medulloblastoma patient leukapheresis following induction chemotherapy and granulocyte colony stimulating factor mobilization were cryopreserved prior to use in DC generation. DCs were generated from the adherent CD14+ monocytes using standard procedures and analyzed for cell recovery, phenotype and function. To summarize, 4 out of 5 patients (80%) had sufficient monocyte recovery to permit DC generation, and we were able to generate DCs from 3 out of these 4 patient samples (75%). Overall, we successfully generated DCs that met phenotypic requisites for DC-based cancer therapy from 3 out of 5 (60%) patient samples and met both phenotypic and functional requisites from 2 out of 5 (40%) patient samples. This study highlights the potential to generate functional DCs for further clinical treatments from refractory patients that have been heavily pretreated with myelosuppressive chemotherapy. Here we demonstrate the utility of evaluating the effect of the currently employed standard-of-care therapies on the ex vivo generation of DCs for DC-based clinical studies in cancer patients.

  20. Developing a Patient Care Co-ordination Centre in Trafford, England: lessons from the International Foundation for Integrated Care (IFIC/Advancing Quality Alliance integrated care fellowship experience

    Directory of Open Access Journals (Sweden)

    Michael Gregory

    2015-05-01

    Full Text Available The NHS and Social Care in England are facing one of the biggest financial challenges for a generation. Commissioners and providers need to work on collaborative schemes to manage the increasing demand on health and social care within a period of financial constraint. Different forms of care co-ordination have been developed at different levels across the world.In the north-west of England, the Trafford health and social care economy have been working through a competitive dialogue process with industry to develop an innovative and dynamic solution to deliver seamless co-ordination for all patients and service users. The strategy is to develop a new Patient Care Co-ordination Centre, which will be responsible for the delivery of co-ordinated, quality care. The Patient Care Co-ordination Centre will work at clinical, service, functional and community levels across multiple providers covering risk stratification, preventative, elective and unscheduled care.I am the clinical lead for the Patient Care Co-ordination Centre and during my year as an Advancing Quality Alliance Integrated Care Fellow, I have had the opportunity to study examples of care coordination from UK and international sites. The learning from these visits has been assimilated into the design process of the Patient Care Co-ordination Centre.

  1. Developing a Patient Care Co-ordination Centre in Trafford, England: lessons from the International Foundation for Integrated Care (IFIC/Advancing Quality Alliance integrated care fellowship experience

    Directory of Open Access Journals (Sweden)

    Michael Gregory

    2015-05-01

    Full Text Available The NHS and Social Care in England are facing one of the biggest financial challenges for a generation. Commissioners and providers need to work on collaborative schemes to manage the increasing demand on health and social care within a period of financial constraint. Different forms of care co-ordination have been developed at different levels across the world. In the north-west of England, the Trafford health and social care economy have been working through a competitive dialogue process with industry to develop an innovative and dynamic solution to deliver seamless co-ordination for all patients and service users. The strategy is to develop a new Patient Care Co-ordination Centre, which will be responsible for the delivery of co-ordinated, quality care. The Patient Care Co-ordination Centre will work at clinical, service, functional and community levels across multiple providers covering risk stratification, preventative, elective and unscheduled care. I am the clinical lead for the Patient Care Co-ordination Centre and during my year as an Advancing Quality Alliance Integrated Care Fellow, I have had the opportunity to study examples of care coordination from UK and international sites. The learning from these visits has been assimilated into the design process of the Patient Care Co-ordination Centre.

  2. Thirty-five Infantile Purpura Nephritis Patients Treated with Integrated Traditional Chinese and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    ZHENG; Tian-wen

    2001-01-01

    Thirty-five patients of infantile purpura nephritis (IPN) were treated with integrated traditional Chinese and western medicine (TCM-WM) from January 1994 to December 1998, with good efficacy obtained, and following is the report.

  3. 78 FR 79619 - Patient Protection and Affordable Care Act; Program Integrity: Exchange, Premium Stabilization...

    Science.gov (United States)

    2013-12-31

    ...-9957-CN; 9964-CN] RIN 0938-AR82; RIN 0938-AR74 Patient Protection and Affordable Care Act; Program... Affordable Care Act; Program Integrity: Exchange, Premium Stabilization Programs, and Market Standards... and Affordable Care Act; Program Integrity: Exchange, Premium Stabilization Programs, and...

  4. Widespread reductions of white matter integrity in patients with long-term remission of Cushing's disease

    Directory of Open Access Journals (Sweden)

    Steven J.A. van der Werff

    2014-01-01

    Conclusion: Patients with a history of endogenous hypercortisolism in present remission show widespread changes of white matter integrity in the brain, with abnormalities in the integrity of the uncinate fasciculus being related to the severity of depressive symptoms, suggesting persistent structural effects of hypercortisolism.

  5. Probabilistic integrity assessment of CANDU pressure tube for the consideration of flaw generation time

    Energy Technology Data Exchange (ETDEWEB)

    Kwak, Sang Log; Kim, Young Jin [Sungkyunkwan Univ., Seoul (Korea, Republic of); Lee, Joon Seong [Kyonggi Univ., Seoul (Korea, Republic of); Park, Youn Won [KINS, Taejon (Korea, Republic of)

    2001-07-01

    This paper describes a Probabilistic Fracture Mechanics (PFM) analysis based on Monte Carlo (MC) simulation. In the analysis of CANDU pressure tube, it is necessary to perform the PFM analyses based on statistical consideration of flaw generation time. A depth and an aspect ratio of initial semi-elliptical surface crack, a fracture toughness value, Delayed Hydride Cracking (DHC) velocity, and flaw generation time are assumed to be probabilistic variables. In all the analyses, degradation of fracture toughness due to neutron irradiation is considered. Also, the failure criteria considered are plastic collapse, unstable fracture and crack penetration. For the crack growth by DHC, the failure probability was evaluated in due consideration of flaw generation time.

  6. Generating a non-integrating human induced pluripotent stem cell bank from urine-derived cells.

    Directory of Open Access Journals (Sweden)

    Yanting Xue

    Full Text Available Induced pluripotent stem cell (iPS cell holds great potential for applications in regenerative medicine, drug discovery, and disease modeling. We describe here a practical method to generate human iPS cells from urine-derived cells (UCs under feeder-free, virus-free, serum-free condition and without oncogene c-MYC. We showed that this approach could be applied in a large population with different genetic backgrounds. UCs are easily accessible and exhibit high reprogramming efficiency, offering advantages over other cell types used for the purpose of iPS generation. Using the approach described in this study, we have generated 93 iPS cell lines from 20 donors with diverse genetic backgrounds. The non-viral iPS cell bank with these cell lines provides a valuable resource for iPS cells research, facilitating future applications of human iPS cells.

  7. Study of the integration of distributed generation systems in the grid: application in micro-grids; Etude de structures d'integration des systemes de generation decentralisee: application aux microreseaux

    Energy Technology Data Exchange (ETDEWEB)

    Gaztanaga Arantzamendi, H

    2006-12-15

    The present PhD deals with an original micro-grid concept and its application as a Renewable Energy Source's (RES) grid integration scheme. This micro-grid is composed of RES generators as well as support systems that incorporate additional functionalities in order to improve RES integration into the grid. According to this concept, two practical micro-grid applications have been studied in detail: a residential micro-grid and a wind farm supported by DFACTS systems (STATCOM and DVR). In both applications, the control structures which are implemented at different levels and applied to the different micro-grid elements have been developed, analyzed by means of off-line simulations and finally validated in real-time conditions with physical reduced-scale prototypes. (author)

  8. Dual representation for the generating functional of the Feynman path-integral

    Directory of Open Access Journals (Sweden)

    Marco Matone

    2016-09-01

    Full Text Available The generating functional for scalar theories admits a representation which is dual with respect to the one introduced by Schwinger, interchanging the role of the free and interacting terms. It maps ∫V(δJ and JΔJ to δϕcΔδϕc and ∫V(ϕc, respectively, with ϕc=∫JΔ and Δ the Feynman propagator. Comparing the Schwinger representation with its dual version one gets a little known relation that we prove to be a particular case of a more general operatorial relation. We then derive a new representation of the generating functional T[ϕc]=W[J] expressed in terms of covariant derivatives acting on 1 T[ϕc]=NN0exp⁡(−U0[ϕc]exp⁡(−∫V(Dϕc−⋅1 where Dϕ±(x=∓Δδδϕ(x+ϕ(x. The dual representation, which is deeply related to the Hermite polynomials, is the key to express the generating functional associated to a sum of potentials in terms of factorized generating functionals. This is applied to renormalization, leading to a factorization of the counterterms of the interaction. We investigate the structure of the functional generator for normal ordered potentials and derive an infinite set of relations in the case of the potential λn!:ϕn: . Such relations are explicitly derived by using the Faà di Bruno formula. This also yields the explicit expression of the generating functional of connected Green's functions.

  9. On the accuracy and reproducibility of a novel probabilistic atlas-based generation for calculation of head attenuation maps on integrated PET/MR scanners

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Kevin T. [Massachusetts General Hospital and Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, MA (United States); Massachusetts Institute of Technology, Division of Health Sciences and Technology, Cambridge, MA (United States); Izquierdo-Garcia, David; Catana, Ciprian [Massachusetts General Hospital and Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, MA (United States); Poynton, Clare B. [Massachusetts General Hospital and Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, MA (United States); Massachusetts General Hospital, Department of Psychiatry, Boston, MA (United States); University of California, San Francisco, Department of Radiology and Biomedical Imaging, San Francisco, CA (United States); Chonde, Daniel B. [Massachusetts General Hospital and Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, MA (United States); Harvard University, Program in Biophysics, Cambridge, MA (United States)

    2017-03-15

    To propose an MR-based method for generating continuous-valued head attenuation maps and to assess its accuracy and reproducibility. Demonstrating that novel MR-based photon attenuation correction methods are both accurate and reproducible is essential prior to using them routinely in research and clinical studies on integrated PET/MR scanners. Continuous-valued linear attenuation coefficient maps (''μ-maps'') were generated by combining atlases that provided the prior probability of voxel positions belonging to a certain tissue class (air, soft tissue, or bone) and an MR intensity-based likelihood classifier to produce posterior probability maps of tissue classes. These probabilities were used as weights to generate the μ-maps. The accuracy of this probabilistic atlas-based continuous-valued μ-map (''PAC-map'') generation method was assessed by calculating the voxel-wise absolute relative change (RC) between the MR-based and scaled CT-based attenuation-corrected PET images. To assess reproducibility, we performed pair-wise comparisons of the RC values obtained from the PET images reconstructed using the μ-maps generated from the data acquired at three time points. The proposed method produced continuous-valued μ-maps that qualitatively reflected the variable anatomy in patients with brain tumor and agreed well with the scaled CT-based μ-maps. The absolute RC comparing the resulting PET volumes was 1.76 ± 2.33 %, quantitatively demonstrating that the method is accurate. Additionally, we also showed that the method is highly reproducible, the mean RC value for the PET images reconstructed using the μ-maps obtained at the three visits being 0.65 ± 0.95 %. Accurate and highly reproducible continuous-valued head μ-maps can be generated from MR data using a probabilistic atlas-based approach. (orig.)

  10. An Integrated microfluidic platform for liquid droplet in gas flow generation with in liquid flow collection and manipulation

    Science.gov (United States)

    Tirandazi, Pooyan; Hidrovo, Carlos H.

    2016-11-01

    Discretization of biological samples and chemical reactions within digital droplets is a powerful technique which has rapidly emerged in many biochemical syntheses. The ability to generate, manipulate, and monitor millions of microdroplets in a short time provides great potential for high throughput screening and detection in microbiology. Here we report a microfluidic device for the formation of uniform microdroplets (50 μm-100 μm) using a high speed gas as the continuous phase. Gas-borne droplets are generated in a chip-based flow-focusing device fabricated in PDMS, and travel along the gaseous microchannel and are subsequently captured within a second liquid phase. The droplets are then transferred and collected in a minichamber and move into the manipulation section for further processing operations on the drops. All these steps are performed automatically in a single multilayer chip. This integrated microfluidic platform for generation, collection, and manipulation of the droplets provides great opportunities for monitoring and detection of gas-analytes. Utilizing the generated picoliter airborne droplets feature lower reaction times and higher transfer rates as compared to conventional air sampling techniques. Thus, it can greatly facilitate the investigation of airborne analytes by interrogation of the digital droplets using different analytical techniques. Furthermore, the presented liquid-in-gas generation method can be utilized for production of oil-free microparticles and microcapsules used in the food industry and for drug delivery.

  11. DESIGN NOTE: Development of an integrated solid-state generator for light inactivation of food-related pathogenic bacteria

    Science.gov (United States)

    Ghasemi, Z.; Macgregor, S.; Anderson, J.; Lamont, Y.

    2003-06-01

    This paper is concerned with the design and performance of a fully integrated solid-state Marx generator, which has been developed to drive a UV flashlamp for use in microbiological inactivation. The generator has an output voltage rating of 3 kV and a peak current rating of 2 kA, although the modular approach taken allows for a number of voltage and current ratings to be achieved. The generator is constructed using a number of series- and parallel-connected 1.2 kV insulated-gate-bipolar-transistor (IGBT) switched capacitors. Switching of the IGBT modules is controlled by an optical signal. Details are given of how the optimum IGBT gate-drive circuit is achieved using optical components and a pass-through wire to provide the required energies for individual IGBT modules. The generator is demonstrated as the driver of a UV flashlamp used for inactivation of food-related pathogenic bacteria such as E. coli and Salmonella. The performance of the Marx generator over a period of 106 pulses is examined, along with the changes that occur in the spectrum of the UV flashlamp during the same period.

  12. Psychometric Characteristics of a Patient Reported Outcome Measure on Ego-Integrity and Despair among Cancer Patients.

    Directory of Open Access Journals (Sweden)

    Gitta Kleijn

    Full Text Available To evaluate psychometric characteristics of a questionnaire (the Northwestern Ego-integrity Scale (NEIS on ego-integrity (the experience of wholeness and meaning in life, even in spite of negative experiences and despair (the experience of regret about the life one has led, and feelings of sadness, failure and hopelessness among cancer patients.Cancer patients (n = 164 completed patient reported outcome measures on ego-integrity and despair (NEIS, psychological distress, anxiety and depression (Hospital Anxiety and Depression Scale (HADS, and quality of life (EORTC QLQ-C30 (cancer survivors, n = 57 or EORTC QLQ-C15-PAL (advanced cancer patients, n = 107. Confirmatory Factor Analysis was used to assess construct validity. Cronbach's alpha was used to assess internal consistency. Convergent validity was tested based on a priori defined hypotheses: a higher level of ego-integrity was expected to be related to a higher level of quality of life, and lower levels of distress, depression and anxiety; a higher level of despair was expected to be related to a lower level of quality of life, and higher levels of distress, depression and anxiety.The majority of all items (94.5% of the NEIS were completed by patients and single item missing rate was below 2%. The two subscales, labeled as Ego-integrity (5 items and Despair (4 items had acceptable internal consistency (Cronbach's alpha .72 and .61, respectively. The Ego-integrity subscale was not significantly associated with quality of life, distress, anxiety, or depression. The Despair subscale correlated significantly (p <.001 with quality of life (r = -.29, distress (r = .44, anxiety (r = .47 and depression (r = .32.The NEIS has good psychometric characteristics to assess ego-integrity and despair among cancer patients.

  13. Naval Open Architecture Machinery Control Systems for Next Generation Integrated Power Systems

    Science.gov (United States)

    2012-05-01

    Step-Down Converters for High Voltage Direct Current ( HVDC ) Transmission Systems Zonal Electrical Distribution Systems For NGIPS, multifunction...Transmission ( HVDC ),  Distributed Generation, and  Energy Storage applications. The focus was on high power applications ranging from one to

  14. Network investments and the integration of distributed generation: Regulatory recommendations for the Dutch electricity industry

    NARCIS (Netherlands)

    Niesten, E.M.M.I.

    2010-01-01

    An increase in the distributed generation of electricity necessitates investments in the distribution network. The current tariff regulation in the Dutch electricity industry, with its ex post evaluation of the efficiency of investments, average benchmarking and a frontier shift in the x-factor, del

  15. The Attitudes and Behaviors of Generational Students towards Academic Integrity at the Community College

    Science.gov (United States)

    Christensen, Jeannine M.

    2011-01-01

    Academic dishonesty is a problem that educators face at all levels of education. Many studies have focused on researching academic dishonesty at four year colleges and universities, ignoring the community college. The purpose of this study was to examine the self-reported attitudes and behaviors of generational students towards academic integrity…

  16. Third harmonic generation as a rapid selection tool for organic materials for nonlinear integrated optics devices

    NARCIS (Netherlands)

    Blom, F.C.; Driessen, A.; Hoekstra, Hugo; van Schoot, J.B.P.; van Schoot, Jan B.P.; Popma, T.J.A.

    1999-01-01

    In the long trajectory from the synthesis of organic nonlinear optical materials to the completed all-optical device it is highly desirable to be able to concentrate already in an early state on only a few promising materials. Third harmonic generation (THG) is a very convenient method as it allows

  17. The Attitudes and Behaviors of Generational Students towards Academic Integrity at the Community College

    Science.gov (United States)

    Christensen, Jeannine M.

    2011-01-01

    Academic dishonesty is a problem that educators face at all levels of education. Many studies have focused on researching academic dishonesty at four year colleges and universities, ignoring the community college. The purpose of this study was to examine the self-reported attitudes and behaviors of generational students towards academic integrity…

  18. Finding Alignment: The Perceptions and Integration of the Next Generation Science Standards Practices by Elementary Teachers

    Science.gov (United States)

    Smith, Janette; Nadelson, Louis

    2017-01-01

    Preparing elementary-level teachers to teach in alignment with the eight Next Generation Science Standards (NGSS) practices could prove to be a daunting endeavor. However, the process may be catalyzed by leveraging elements of teacher science instruction that inherently attend to the practice standards. In this study, we investigated the science…

  19. Third harmonic generation as a rapid selection tool for organic materials for nonlinear integrated optics devices

    NARCIS (Netherlands)

    Blom, Freek C.; Driessen, Alfred; Hoekstra, Hugo J.W.M.; Schoot, van Jan B.P.; Popma, Th.J.A.

    1999-01-01

    In the long trajectory from the synthesis of organic nonlinear optical materials to the completed all-optical device it is highly desirable to be able to concentrate already in an early state on only a few promising materials. Third harmonic generation (THG) is a very convenient method as it allows

  20. ‘Standard’ incentive regulation hinders the integration of renewable energy generation

    NARCIS (Netherlands)

    Nykamp, Stefan; Andor, Mark; Hurink, Johann L.

    2012-01-01

    The connection and distribution of growing, decentralized electricity generation from renewable energy sources (RES-E) is leading tomassive investment needs. Besides investing in additional ‘conventional’ assets (e.g. cables), grid operators can also invest in innovative ‘smart solutions’ like local

  1. ‘Standard’ incentive regulation hinders the integration of renewable energy generation

    NARCIS (Netherlands)

    Nykamp, Stefan; Andor, Mark; Hurink, Johann L.

    2012-01-01

    The connection and distribution of growing, decentralized electricity generation from renewable energy sources (RES-E) is leading tomassive investment needs. Besides investing in additional ‘conventional’ assets (e.g. cables), grid operators can also invest in innovative ‘smart solutions’ like local

  2. Generation of a stable packaging cell line producing high-titer PPT-deleted integration-deficient lentiviral vectors

    Directory of Open Access Journals (Sweden)

    Peirong Hu

    2015-01-01

    Full Text Available The risk of insertional mutagenesis inherent to all integrating exogenous expression cassettes was the impetus for the development of various integration-defective lentiviral vector (IDLV systems. These systems were successfully employed in a plethora of preclinical applications, underscoring their clinical potential. However, current production of IDLVs by transient plasmid transfection is not optimal for large-scale production of clinical grade vectors. Here, we describe the development of the first tetracycline-inducible stable IDLV packaging cell line comprising the D64E integrase mutant and the VSV-G envelope protein. A conditional self-inactivating (cSIN vector and a novel polypurine tract (PPT-deleted vector were incorporated into the newly developed stable packaging cell line by transduction and stable transfection, respectively. High-titer (∼107 infectious units (IU/ml cSIN vectors were routinely generated. Furthermore, screening of single-cell clones stably transfected with PPT-deleted vector DNA resulted in the identification of highly efficient producer cell lines generating IDLV titers higher than 108 IU/mL, which upon concentration increased to 1010 IU/ml. IDLVs generated by stable producer lines efficiently transduce CNS tissues of rodents. Overall, the availability of high-titer IDLV lentivirus packaging cell line described here will significantly facilitate IDLV-based basic science research, as well as preclinical and clinical applications.

  3. Generation of a stable packaging cell line producing high-titer PPT-deleted integration-deficient lentiviral vectors.

    Science.gov (United States)

    Hu, Peirong; Li, Yedda; Sands, Mark S; McCown, Thomas; Kafri, Tal

    2015-01-01

    The risk of insertional mutagenesis inherent to all integrating exogenous expression cassettes was the impetus for the development of various integration-defective lentiviral vector (IDLV) systems. These systems were successfully employed in a plethora of preclinical applications, underscoring their clinical potential. However, current production of IDLVs by transient plasmid transfection is not optimal for large-scale production of clinical grade vectors. Here, we describe the development of the first tetracycline-inducible stable IDLV packaging cell line comprising the D64E integrase mutant and the VSV-G envelope protein. A conditional self-inactivating (cSIN) vector and a novel polypurine tract (PPT)-deleted vector were incorporated into the newly developed stable packaging cell line by transduction and stable transfection, respectively. High-titer (~10(7) infectious units (IU)/ml) cSIN vectors were routinely generated. Furthermore, screening of single-cell clones stably transfected with PPT-deleted vector DNA resulted in the identification of highly efficient producer cell lines generating IDLV titers higher than 10(8) IU/mL, which upon concentration increased to 10(10) IU/ml. IDLVs generated by stable producer lines efficiently transduce CNS tissues of rodents. Overall, the availability of high-titer IDLV lentivirus packaging cell line described here will significantly facilitate IDLV-based basic science research, as well as preclinical and clinical applications.

  4. Classical Completely Integrable System Generated through Nonlinearization of an Eigenvalue Problem

    Institute of Scientific and Technical Information of China (English)

    LUOMant; LIXiu-li; XIANGMing-sen

    2004-01-01

    Under the Bargmann constrained condition, the spatial part of a new Lax pairof the higher order MkdV equation is nonlinearized to be a completely integrable system(R2N,dp∧dq, H0=1/2F0)(F0=〈Aq,p〉+〈Ap, p〉+〈p,q〉2). While the nonlinearization of the time part leads to its N-involutive system (Fm).

  5. Treatment of Oil Wastewater and Electricity Generation by Integrating Constructed Wetland with Microbial Fuel Cell

    OpenAIRE

    Qiao Yang; Zhenxing Wu; Lifen Liu; Fengxiang Zhang; Shengna Liang

    2016-01-01

    Conventional oil sewage treatment methods can achieve satisfactory removal efficiency, but energy consumption problems during the process of oil sewage treatment are worth attention. The integration of a constructed wetland reactor and a microbial fuel cell reactor (CW-MFC) to treat oil-contaminated wastewater, compared with a microbial fuel cell reactor (MFC) alone and a constructed wetland reactor (CW) alone, was explored in this research. Performances of the three reactors including chemic...

  6. An integrable Poisson map generated from the eigenvalue problem of the Lotka-Volterra hierarchy

    Energy Technology Data Exchange (ETDEWEB)

    Wu Yongtang [Department of Computer Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong (China); Wang Hongye [Department of Mathematics, Zhengzhou University, Henan (China); Du Dianlou [Department of Mathematics, Zhengzhou University, Henan (China)]. E-mail: ddl@zzu.edu.cn

    2002-05-03

    A 3x3 discrete eigenvalue problem associated with the Lotka-Volterra hierarchy is studied and the corresponding nonlinearized one, an integrable Poisson map with a Lie-Poisson structure, is also presented. Moreover, a 2x2 nonlinearized eigenvalue problem, which also begets the Lotka-Volterra hierarchy, is proved to be a reduction of the Poisson map on the leaves of the symplectic foliation. (author)

  7. Altered corticomotor-cerebellar integrity in young ataxia telangiectasia patients.

    Science.gov (United States)

    Sahama, Ishani; Sinclair, Kate; Fiori, Simona; Pannek, Kerstin; Lavin, Martin; Rose, Stephen

    2014-09-01

    Magnetic resonance imaging (MRI) research in identifying altered brain structure and function in ataxia-telangiectasia, an autosomal recessive neurodegenerative disorder, is limited. Diffusion-weighted MRI were obtained from 11 ataxia telangiectasia patients (age range, 7-22 years; mean, 12 years) and 11 typically developing age-matched participants (age range, 8-23 years; mean, 13 years). Gray matter volume alterations in patients were compared with those of healthy controls using voxel-based morphometry, whereas tract-based spatial statistics was employed to elucidate white matter microstructure differences between groups. White matter microstructure was probed using quantitative fractional anisotropy and mean diffusivity measures. Reduced gray matter volume in both cerebellar hemispheres and in the precentral-postcentral gyrus in the left cerebral hemisphere was observed in ataxia telangiectasia patients compared with controls (P ataxia telangiectasia patients along with white matter tract degeneration projecting from the cerebellum into corticomotor regions. The lack of cortical involvement may reflect early-stage white matter motor pathway degeneration within young patients. © 2014 International Parkinson and Movement Disorder Society.

  8. Parallel streams versus integrated timing in multilimb pattern generation: A test of Korte's Third Law.

    Science.gov (United States)

    Jagacinski, Richard J; Rizzi, Emanuele; Kim, Tae Hoon; Lavender, Steven A; Speller, Lassiter F; Klapp, Stuart T

    2016-11-01

    Skilled drummers performed a 4:3:2 polyrhythm with 2 hands and 1 foot. For each pair of limbs patterns of temporal covariation were used to infer relatively independent parallel streams versus integrated timing relationships. Parallel timing was more prevalent between hand and foot than between the 2 hands, and parallel timing generally increased with tapping rate. Different combinations of integrated and parallel timing were found among the 3 limbs. A second experiment used a wider range of tapping rates and explored 3:2 tapping with 2 hands, 2 feet, or hand and foot. The latter 2 limb pairs resulted in greater prevalence of parallel timing. These results can be interpreted in terms of a Gestalt principle of grouping known as Korte's Third Law, which can be extended from the perceptual domain to the perceptual-motor domain. This principle indicates that perceived velocity is a key factor in determining whether a sequence of events is represented as a single integrated pattern or as multiple parallel patterns. The present results put disparate previous findings on bimanual polyrhythmic tapping and rhythmic aspects of the golf swing under a common theoretical perspective. (PsycINFO Database Record

  9. Structured Integration Test Suite Generation Process for Multi-Agent System

    Directory of Open Access Journals (Sweden)

    Z. Houhamdi

    2011-01-01

    Full Text Available Problem statement: In recent years, Agent-Oriented Software Engineering (AOSE methodologies are proposed to develop complex distributed systems based upon the agent paradigm. The implementation for such systems has usually the form of Multi-Agent Systems (MAS. Testing of MAS is a challenging task because these systems are often programmed to be autonomous and deliberative and they operate in an open world, which requires context awareness. Approach: We introduce a novel approach for goal-oriented software integration testing. It specifies an integration testing process that complements the goal oriented methodology Tropos and strengthens the mutual relationship between goal analysis and testing. Results: The derived test suites from the system goals can be used to observe emergent properties resulting from agent interactions and make sure that a group of agents and contextual resources work correctly together. Conclusion: This approach defines a structured and comprehensive integration test suite derivation process for engineering software agents by providing a systematic way of deriving test cases from goal analysis.

  10. Integrating agricultural and environmental sustainability across generations: the never-ending quest for the golden fleece

    Directory of Open Access Journals (Sweden)

    Marc Janssens

    2015-03-01

    Full Text Available Dynamic agricultural sustainability strongly depends on a reliable energy resource that is capable of maintaining order in an open (agro-eco- system at the expense of the order of the environment. In this article, the integrative and complex challenges of combining efficient farming with environmental upgrading are analysed. Farming should be practiced within an appropriate, though moving agro-climax, the impact of which has become more important than that of the remaining natural ecosystems. Efficient use of resources and energy is not only important during the concentration phase of farming, but even more important during the dilution phase. The best way of improving the eco-capacity of farming systems is to increase the vitality of the agrosphere i.e. assimilation capacity of abiotic inputs necessary for crop intensification. This will require hands-on guidelines for the farmer amongst which integrated plant nutrition and the integration of organic and inorganic fertilisation will allow both sustainable and intensive production systems. The intergenerational adoption of the latter will be proof of their sustainable character.

  11. Integration

    DEFF Research Database (Denmark)

    Emerek, Ruth

    2004-01-01

    Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration......Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration...

  12. Integrating patient safety into health professionals' curricula: a qualitative study of medical, nursing and pharmacy faculty perspectives.

    Science.gov (United States)

    Tregunno, Deborah; Ginsburg, Liane; Clarke, Beth; Norton, Peter

    2014-03-01

    As efforts to integrate patient safety into health professional curricula increase, there is growing recognition that the rate of curricular change is very slow, and there is a shortage of research that addresses critical perspectives of faculty who are on the 'front-lines' of curricular innovation. This study reports on medical, nursing and pharmacy teaching faculty perspectives about factors that influence curricular integration and the preparation of safe practitioners. Qualitative methods were used to collect data from 20 faculty members (n=6 medical from three universities; n=6 pharmacy from two universities; n=8 nursing from four universities) engaged in medical, nursing and pharmacy education. Thematic analysis generated a comprehensive account of faculty perspectives. Faculty perspectives on key challenges to safe practice vary across the three disciplines, and these different perspectives lead to different priorities for curricular innovation. Additionally, accreditation and regulatory requirements are driving curricular change in medicine and pharmacy. Key challenges exist for health professional students in clinical teaching environments where the culture of patient safety may thwart the preparation of safe practitioners. Patient safety curricular innovation depends on the interests of individual faculty members and the leveraging of accreditation and regulatory requirements. Building on existing curricular frameworks, opportunities now need to be created for faculty members to act as champions of curricular change, and patient safety educational opportunities need to be harmonises across all health professional training programmes. Faculty champions and practice setting leaders can collaborate to improve the culture of patient safety in clinical teaching and learning settings.

  13. Audiovisual Integration of Speech in a Patient with Broca’s Aphasia

    DEFF Research Database (Denmark)

    Andersen, Tobias; Starrfelt, Randi

    2015-01-01

    's area is necessary for audiovisual integration of speech. Here we describe a patient with Broca's aphasia who experienced the McGurk illusion. This indicates that an intact Broca's area is not necessary for audiovisual integration of speech. The McGurk illusions this patient experienced were atypical......, which could be due to Broca's area having a more subtle role in audiovisual integration of speech. The McGurk illusions of a control subject with Wernicke's aphasia were, however, also atypical. This indicates that the atypical McGurk illusions were due to deficits in speech processing...

  14. Impaired thrombin generation and fibrin clot formation in patients with dilutional coagulopathy during major surgery.

    NARCIS (Netherlands)

    Schols, S.E.; Lance, M.D.; Feijge, M.A.; Damoiseaux, J.; Marcus, M.A.; Hamulyak, K.; Cate, H. ten; Heemskerk, J.W.M.; Pampus, E.C.M. van

    2010-01-01

    Patients subjected to haemodilution during surgery are at increased risk of bleeding. We hypothesised that, in the acquired dilutional coagulopathy, insufficient haemostasis is due to either insufficient thrombin generation or insufficient fibrin clot formation. In tissue factor-activated plasmas fr

  15. A Parametric Empirical Bayesian framework for the EEG/MEG inverse problem: generative models for multisubject and multimodal integration

    Directory of Open Access Journals (Sweden)

    Richard N Henson

    2011-08-01

    Full Text Available We review recent methodological developments within a Parametric Empirical Bayesian (PEB framework for reconstructing intracranial sources of extracranial electroencephalographic (EEG and magnetoencephalographic (MEG data under linear Gaussian assumptions. The PEB framework offers a natural way to integrate multiple constraints (spatial priors on this inverse problem, such as those derived from different modalities (e.g., from functional magnetic resonance imaging, fMRI or from multiple replications (e.g., subjects. Using variations of the same basic generative model, we illustrate the application of PEB to three cases: 1 symmetric integration (fusion of MEG and EEG; 2 asymmetric integration of MEG or EEG with fMRI, and 3 group-optimisation of spatial priors across subjects. We evaluate these applications on multimodal data acquired from 18 subjects, focusing on energy induced by face perception within a time-frequency window of 100-220ms, 8-18Hz. We show the benefits of multi-modal, multi-subject integration in terms of the model evidence and the reproducibility (over subjects of cortical responses to faces.

  16. Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing.

    Directory of Open Access Journals (Sweden)

    Winnie S Liang

    Full Text Available Pancreatic adenocarcinoma (PAC is among the most lethal malignancies. While research has implicated multiple genes in disease pathogenesis, identification of therapeutic leads has been difficult and the majority of currently available therapies provide only marginal benefit. To address this issue, our goal was to genomically characterize individual PAC patients to understand the range of aberrations that are occurring in each tumor. Because our understanding of PAC tumorigenesis is limited, evaluation of separate cases may reveal aberrations, that are less common but may provide relevant information on the disease, or that may represent viable therapeutic targets for the patient. We used next generation sequencing to assess global somatic events across 3 PAC patients to characterize each patient and to identify potential targets. This study is the first to report whole genome sequencing (WGS findings in paired tumor/normal samples collected from 3 separate PAC patients. We generated on average 132 billion mappable bases across all patients using WGS, and identified 142 somatic coding events including point mutations, insertion/deletions, and chromosomal copy number variants. We did not identify any significant somatic translocation events. We also performed RNA sequencing on 2 of these patients' tumors for which tumor RNA was available to evaluate expression changes that may be associated with somatic events, and generated over 100 million mapped reads for each patient. We further performed pathway analysis of all sequencing data to identify processes that may be the most heavily impacted from somatic and expression alterations. As expected, the KRAS signaling pathway was the most heavily impacted pathway (P<0.05, along with tumor-stroma interactions and tumor suppressive pathways. While sequencing of more patients is needed, the high resolution genomic and transcriptomic information we have acquired here provides valuable information on the

  17. Wind Energy Management System Integration Project Incorporating Wind Generation and Load Forecast Uncertainties into Power Grid Operations

    Energy Technology Data Exchange (ETDEWEB)

    Makarov, Yuri V.; Huang, Zhenyu; Etingov, Pavel V.; Ma, Jian; Guttromson, Ross T.; Subbarao, Krishnappa; Chakrabarti, Bhujanga B.

    2010-09-01

    features make this work a significant step forward toward the objective of incorporating of wind, solar, load, and other uncertainties into power system operations. In this report, a new methodology to predict the uncertainty ranges for the required balancing capacity, ramping capability and ramp duration is presented. Uncertainties created by system load forecast errors, wind and solar forecast errors, generation forced outages are taken into account. The uncertainty ranges are evaluated for different confidence levels of having the actual generation requirements within the corresponding limits. The methodology helps to identify system balancing reserve requirement based on a desired system performance levels, identify system “breaking points”, where the generation system becomes unable to follow the generation requirement curve with the user-specified probability level, and determine the time remaining to these potential events. The approach includes three stages: statistical and actual data acquisition, statistical analysis of retrospective information, and prediction of future grid balancing requirements for specified time horizons and confidence intervals. Assessment of the capacity and ramping requirements is performed using a specially developed probabilistic algorithm based on a histogram analysis incorporating all sources of uncertainty and parameters of a continuous (wind forecast and load forecast errors) and discrete (forced generator outages and failures to start up) nature. Preliminary simulations using California Independent System Operator (California ISO) real life data have shown the effectiveness of the proposed approach. A tool developed based on the new methodology described in this report will be integrated with the California ISO systems. Contractual work is currently in place to integrate the tool with the AREVA EMS system.

  18. INTEGRATION OF POINT CLOUDS FROM TERRESTRIAL LASER SCANNING AND IMAGE-BASED MATCHING FOR GENERATING HIGH-RESOLUTION ORTHOIMAGES

    Directory of Open Access Journals (Sweden)

    A. Salach

    2016-06-01

    Full Text Available An orthoimage is one of the basic photogrammetric products used for architectural documentation of historical objects; recently, it has become a standard in such work. Considering the increasing popularity of photogrammetric techniques applied in the cultural heritage domain, this research examines the two most popular measuring technologies: terrestrial laser scanning, and automatic processing of digital photographs. The basic objective of the performed works presented in this paper was to optimize the quality of generated high-resolution orthoimages using integration of data acquired by a Z+F 5006 terrestrial laser scanner and a Canon EOS 5D Mark II digital camera. The subject was one of the walls of the “Blue Chamber” of the Museum of King Jan III’s Palace at Wilanów (Warsaw, Poland. The high-resolution images resulting from integration of the point clouds acquired by the different methods were analysed in detail with respect to geometric and radiometric correctness.

  19. Visual discrimination of delayed self-generated movement reveals the temporal limit of proprioceptive-visual intermodal integration.

    Science.gov (United States)

    Jaime, Mark; O'Driscoll, Kelly; Moore, Chris

    2016-07-01

    This study examined the intermodal integration of visual-proprioceptive feedback via a novel visual discrimination task of delayed self-generated movement. Participants performed a goal-oriented task in which visual feedback was available only via delayed videos displayed on two monitors-each with different delay durations. During task performance, delay duration was varied for one of the videos in the pair relative to a standard delay, which was held constant. Participants were required to identify and use the video with the lesser delay to perform the task. Visual discrimination of the lesser-delayed video was examined under four conditions in which the standard delay was increased for each condition. A temporal limit for proprioceptive-visual intermodal integration of 3-5s was revealed by subjects' inability to reliably discriminate video pairs.

  20. An interation of lifetime monitoring of steam generators in power control systems; Integration der Lebensdauerueberwachung von Dampferzeugern in die Kraftwerksleittechnik

    Energy Technology Data Exchange (ETDEWEB)

    Kunze, Ulrich; Pels Leusden, Christoph; Spinner, Ralf [Siemens AG, Erlangen (Germany). Energy Sector; Hackstein, Holger [Siemens AG, Offenbach am Main (Germany). Energy Sector; Walz, Horst [Siemens AG, Karlsruhe (Germany). Energy Sector

    2008-07-01

    The substantial cost-relevant requirements of the operation of power stations are a highly flexible operation, efficient maintenance, a high efficiency and a high availability. Computer-assisted procedures are indispensable for the continuous monitoring of lifetime consumption and for the condition-dependent maintenance of the boiler. The fatigue monitoring system (FMS) offers all possibilities of the control system. The authors of the contribution under consideration report on an integration of life time monitoring of steam generators into the power station control technology. The technical fundamentals for the computation of the boiler lifetime as well as the fundamentals of integration philosophy and their conversion are presented. Subsequently, a configuration exemplarily is presented, and its results are described.

  1. Integration of Point Clouds from Terrestrial Laser Scanning and Image-Based Matching for Generating High-Resolution Orthoimages

    Science.gov (United States)

    Salach, A.; Markiewicza, J. S.; Zawieska, D.

    2016-06-01

    An orthoimage is one of the basic photogrammetric products used for architectural documentation of historical objects; recently, it has become a standard in such work. Considering the increasing popularity of photogrammetric techniques applied in the cultural heritage domain, this research examines the two most popular measuring technologies: terrestrial laser scanning, and automatic processing of digital photographs. The basic objective of the performed works presented in this paper was to optimize the quality of generated high-resolution orthoimages using integration of data acquired by a Z+F 5006 terrestrial laser scanner and a Canon EOS 5D Mark II digital camera. The subject was one of the walls of the "Blue Chamber" of the Museum of King Jan III's Palace at Wilanów (Warsaw, Poland). The high-resolution images resulting from integration of the point clouds acquired by the different methods were analysed in detail with respect to geometric and radiometric correctness.

  2. A monolithically integrated dual-mode laser for photonic microwave generation and all-optical clock recovery

    Science.gov (United States)

    Yu, Liqiang; Zhou, Daibing; Zhao, Lingjuan

    2014-09-01

    We demonstrate a monolithically integrated dual-mode laser (DML) with narrow-beat-linewidth and wide-beat-tunability. Using a monolithic DFB laser subjected to amplified feedback, photonic microwave generation of up to 45 GHz is obtained with higher than 15 GHz beat frequency tunability. Thanks to the high phase correlation of the two modes and the narrow mode linewidth, a RF linewidth of lower than 50 kHz is measured. Simulations are also carried out to illustrate the dual-mode beat characteristic. Furthermore, using the DML, an all-optical clock recovery for 40  Gbaud NRZ-QPSK signals is demonstrated. Timing jitter of lower than 363 fs (integrated within a frequency range from 100 Hz to 1 GHz) is obtained.

  3. Generation and periodontal differentiation of human gingival fibroblasts-derived integration-free induced pluripotent stem cells

    Energy Technology Data Exchange (ETDEWEB)

    Yin, Xiaohui [Department of Periodontology, School and Hospital of Stomatology, Peking University, 22 South Avenue Zhong-Guan-Cun, Beijing 100081 (China); Peking University Stem Cell Research Center and Department of Cell Biology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191 (China); Li, Yang [Peking University Stem Cell Research Center and Department of Cell Biology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191 (China); Li, Jingwen [Department of Periodontology, School and Hospital of Stomatology, Peking University, 22 South Avenue Zhong-Guan-Cun, Beijing 100081 (China); Li, Peng [Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Hong Kong SAR (China); Liu, Yinan [Peking University Stem Cell Research Center and Department of Cell Biology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191 (China); Wen, Jinhua, E-mail: jhwen@bjmu.edu.cn [Peking University Stem Cell Research Center and Department of Cell Biology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191 (China); Luan, Qingxian, E-mail: kqluanqx@126.com [Department of Periodontology, School and Hospital of Stomatology, Peking University, 22 South Avenue Zhong-Guan-Cun, Beijing 100081 (China)

    2016-05-06

    Induced pluripotent stem cells (iPSCs) have been recognized as a promising cell source for periodontal tissue regeneration. However, the conventional virus-based reprogramming approach is associated with a high risk of genetic mutation and limits their therapeutic utility. Here, we successfully generated iPSCs from readily accessible human gingival fibroblasts (hGFs) through an integration-free and feeder-free approach via delivery of reprogramming factors of Oct4, Sox2, Klf4, L-myc, Lin28 and TP53 shRNA with episomal plasmid vectors. The iPSCs presented similar morphology and proliferation characteristics as embryonic stem cells (ESCs), and expressed pluripotent markers including Oct4, Tra181, Nanog and SSEA-4. Additionally, these cells maintained a normal karyotype and showed decreased CpG methylation ratio in the promoter regions of Oct4 and Nanog. In vivo teratoma formation assay revealed the development of tissues representative of three germ layers, confirming the acquisition of pluripotency. Furthermore, treatment of the iPSCs in vitro with enamel matrix derivative (EMD) or growth/differentiation factor-5 (GDF-5) significantly up-regulated the expression of periodontal tissue markers associated with bone, periodontal ligament and cementum respectively. Taken together, our data demonstrate that hGFs are a valuable cell source for generating integration-free iPSCs, which could be sequentially induced toward periodontal cells under the treatment of EMD and GDF-5. - Highlights: • Integration-free iPSCs are successfully generated from hGFs via an episomal approach. • EMD promotes differentiation of the hGFs-derived iPSCs toward periodontal cells. • GDF-5 promotes differentiation of the hGFs-derived iPSCs toward periodontal cells. • hGFs-derived iPSCs could be a promising cell source for periodontal regeneration.

  4. Prediction of structural integrity of steam generator tubes under severe accident conditions

    Energy Technology Data Exchange (ETDEWEB)

    Majumdar, S. [Argonne National Lab., IL (United States)

    1999-11-01

    Available models for predicting failure of flawed and unflawed steam generator tubes under normal operating and design-basis accident conditions are reviewed. These rate-independent flow stress models are inadequate for predicting failure of steam generator tubes under severe accident conditions because the temperature of the tubes during such accidents can reach as high as 800 C where creep effects become important. Therefore, a creep rupture model for predicting failure was developed and validated by tests on unflawed and flawed specimens containing axial and circumferential flaws and loaded by constant as well as ramped temperature and pressure loadings. Finally, tests were conducted using pressure and temperature histories that are calculated to occur during postulated severe accidents. In all cases, the creep rupture model predicted the failure temperature and time more accurately than the flow stress models. (orig.)

  5. Dual representation for the generating functional of the Feynman path-integral

    Science.gov (United States)

    Matone, Marco

    2016-09-01

    The generating functional for scalar theories admits a representation which is dual with respect to the one introduced by Schwinger, interchanging the role of the free and interacting terms. It maps ∫ V (δJ) and JΔJ to δϕc Δδϕc and ∫ V (ϕc), respectively, with ϕc = ∫ JΔ and Δ the Feynman propagator. Comparing the Schwinger representation with its dual version one gets a little known relation that we prove to be a particular case of a more general operatorial relation. We then derive a new representation of the generating functional T [ϕc ] = W [ J ] expressed in terms of covariant derivatives acting on 1

  6. Integration of Thermoelectric Generators and Wood Stove to Produce Heat, Hot Water, and Electrical Power

    DEFF Research Database (Denmark)

    Goudarzi, A.M.; Mazandarani, P.; Panahi, R.;

    2013-01-01

    Traditional fire stoves are characterized by low efficiency. In this experimental study, the combustion chamber of the stove is developed by two devices. An electric fan can increase the air to fuel ratio in order to increase the system’s efficiency and to decrease the air pollution by providing ....... The presented prototype is designed to fulfill the basic needs of domestic electricity, hot water and the essential heat for warming the room and cooking....... a complete combustion for wood. In addition, thermoelectric generators (TEG) produce power that can be used to satisfy all basic needs. In this study, a water-base cooling system is designed to increase the efficiency of TE generators that also produces hot water for residential uses. Through a range...

  7. Integration of MHD load models with circuit representations the Z generator.

    Energy Technology Data Exchange (ETDEWEB)

    Jennings, Christopher A.; Ampleford, David J.; Jones, Brent Manley; McBride, Ryan D.; Bailey, James E.; Jones, Michael C.; Gomez, Matthew Robert.; Cuneo, Michael Edward; Nakhleh, Charles; Stygar, William A.; Savage, Mark Edward; Wagoner, Timothy C.; Moore, James K.

    2013-03-01

    MHD models of imploding loads fielded on the Z accelerator are typically driven by reduced or simplified circuit representations of the generator. The performance of many of the imploding loads is critically dependent on the current and power delivered to them, so may be strongly influenced by the generators response to their implosion. Current losses diagnosed in the transmission lines approaching the load are further known to limit the energy delivery, while exhibiting some load dependence. Through comparing the convolute performance of a wide variety of short pulse Z loads we parameterize a convolute loss resistance applicable between different experiments. We incorporate this, and other current loss terms into a transmission line representation of the Z vacuum section. We then apply this model to study the current delivery to a wide variety of wire array and MagLif style liner loads.

  8. Improving customer generation by increasing website performance and integrating IT systems

    OpenAIRE

    Ramlall, Shalini; Sanders, David; Powell, Henry; Ndzi, David

    2008-01-01

    This paper describes the research into the design of commercial websites. The research will lead to the identification of design elements that may have significant impact on user behaviour. The research will also investigate how these elements could be altered to provide a better browsing experience to users and ultimately increase online conversion and profit. The research focuses on the design of commercial websites. Their goal is to generate sales by selling products and services online or...

  9. Experimental Verification and Integration of a Next Generation Smart Power Management System

    Science.gov (United States)

    Clemmer, Tavis B.

    With the increase in energy demand by the residential community in this country and the diminishing fossil fuel resources being used for electric energy production there is a need for a system to efficiently manage power within a residence. The Smart Green Power Node (SGPN) is a next generation energy management system that automates on-site energy production, storage, consumption, and grid usage to yield the most savings for both the utility and the consumer. Such a system automatically manages on-site distributed generation sources such as a PhotoVoltaic (PV) input and battery storage to curtail grid energy usage when the price is high. The SGPN high level control features an advanced modular algorithm that incorporates weather data for projected PV generation, battery health monitoring algorithms, user preferences for load prioritization within the home in case of an outage, Time of Use (ToU) grid power pricing, and status of on-site resources to intelligently schedule and manage power flow between the grid, loads, and the on-site resources. The SGPN has a scalable, modular architecture such that it can be customized for user specific applications. This drove the topology for the SGPN which connects on-site resources at a low voltage DC microbus; a two stage bi-directional inverter/rectifier then couples the AC load and residential grid connect to on-site generation. The SGPN has been designed, built, and is undergoing testing. Hardware test results obtained are consistent with the design goals set and indicate that the SGPN is a viable system with recommended changes and future work.

  10. From Spinal Central Pattern Generators to Cortical Network: Integrated BCI for Walking Rehabilitation

    Directory of Open Access Journals (Sweden)

    G. Cheron

    2012-01-01

    Full Text Available Success in locomotor rehabilitation programs can be improved with the use of brain-computer interfaces (BCIs. Although a wealth of research has demonstrated that locomotion is largely controlled by spinal mechanisms, the brain is of utmost importance in monitoring locomotor patterns and therefore contains information regarding central pattern generation functioning. In addition, there is also a tight coordination between the upper and lower limbs, which can also be useful in controlling locomotion. The current paper critically investigates different approaches that are applicable to this field: the use of electroencephalogram (EEG, upper limb electromyogram (EMG, or a hybrid of the two neurophysiological signals to control assistive exoskeletons used in locomotion based on programmable central pattern generators (PCPGs or dynamic recurrent neural networks (DRNNs. Plantar surface tactile stimulation devices combined with virtual reality may provide the sensation of walking while in a supine position for use of training brain signals generated during locomotion. These methods may exploit mechanisms of brain plasticity and assist in the neurorehabilitation of gait in a variety of clinical conditions, including stroke, spinal trauma, multiple sclerosis, and cerebral palsy.

  11. Volt/VAr Optimization of Distribution System with Integrated Distributed Generation

    Directory of Open Access Journals (Sweden)

    MARIAM MUGHEES

    2017-01-01

    Full Text Available This paper addresses the issues of VVO (Volt/VAr Optimization such as loss minimization, acceptable voltage profiles and optimized number of switching operations. Basic function of the DMS (Distribution Management System is to upgrade system intelligence so that it can make dynamic decisions and control the network in realtime. Distributed generators can cause the system to operate above and below the desired limits due to their variable nature. Therefore, devices like SC (Shunt Capacitors and OLTC (On Load Tap Changers are used in distribution system as control devices. Main focus of this paper is to inspect effects of DG (Distributed Generation on switching states of control devices while considering Volt/VAr standards. An optimization search algorithm is employed to search the optimal solution considering the system constraints. The GA (Genetic Algorithm is used for the optimization process of the system and the simulation is done in MATLAB using IEEE-30 bus system with DG under 24 hour changing load profiles. By setting up constraints of distribution system?s voltage limits, capacitor bank and OLTC, losses are minimized up to 50%. Merits of the proposed optimized method are demonstrated through simulation results .The result achieved from the proposed technique has proven to be beneficial for switching optimization of control devices under variant conditions of loads and distributed generation

  12. Spanish approach to research and development applied to steam generator tubes structural integrity and life management

    Energy Technology Data Exchange (ETDEWEB)

    Lozano, J. [Associacion Nuclear Asco AIE, Barcelona (Spain); Bollini, G.J.

    1997-02-01

    The operating experience acquired from certain Spanish Nuclear Power Plant steam generators shows that the tubes, which constitute the second barrier to release of fission products, are susceptible to mechanical damage and corrosion as a result of a variety of mechanisms, among them wastage, pitting, intergranular attack (IGA), stress-corrosion cracking (SCC), fatigue-induced cracking, fretting, erosion/corrosion, support plate denting, etc. These problems, which are common in many plants throughout the world, have required numerous investments by the plants (water treatment plants, replacement of secondary side materials such as condensers and heaters, etc.), have meant costs (operation, inspection and maintenance) and have led to the unavailability of the affected units. In identifying and implementing all these preventive and corrective measures, the Spanish utilities have moved through three successive stages: in the initial stage, the main source of information and of proposals for solutions was the Plant Vendor, whose participation in this respect was based on his own Research and Development programs; subsequently, the Spanish utilities participated jointly in the EPRI Steam Generator Owners Group, collaborating in financing; finally, the Spanish utilities set up their own Steam Generator Research and Development program, while maintaining relations with EPRI programs and those of other countries through information interchange.

  13. Direct measurement of wave-front distortion induced during second-harmonic generation: application to breakup-integral compensation.

    Science.gov (United States)

    Caumes, Jean Pascal; Videau, Laurent; Rouyer, Claude; Freysz, Eric

    2004-04-15

    The wave-front distortion of femtosecond laser pulses recorded with a Shack-Hartmann analyzer makes it possible to retrieve the nonlinear index of refraction of different glasses and the nonlinear phase shift induced during second-harmonic generation in beta-barium borate (BBO) crystal versus the phase mismatch. It is shown that the nonlinear phase shift induced in a 2-mm-thick BBO crystal allows compensation for up to a 2pi breakup-integral induced in a 4-cm fused-silica glass. The stability of the compensation is reported to be from 10 to 100 GW cm(-2).

  14. Next generation bioelectronics: Advances in fabrication coupled with clever chemistries enable the effective integration of biomaterials and organic conductors

    Science.gov (United States)

    Molino, Paul J.; Wallace, Gordon G.

    2015-01-01

    Organic bioelectronics is making an enormous impact in the field of tissue engineering, providing not just biocompatible, but biofunctional conducting material platforms. For their true potential to be reached, it is critical to integrate organic conductors with other biopolymers in a targeted manner, allowing the development of devices and scaffold architectures capable of delivering a number of physical, chemical, and electrical stimuli. Herein, we provide an overview of the methods currently being employed to tailor organic conductors for bioapplications, with a focus on the development of fabrication techniques vital to the development of the next generation of intelligent bionic devices.

  15. Next generation bioelectronics: Advances in fabrication coupled with clever chemistries enable the effective integration of biomaterials and organic conductors

    Directory of Open Access Journals (Sweden)

    Paul J. Molino

    2015-01-01

    Full Text Available Organic bioelectronics is making an enormous impact in the field of tissue engineering, providing not just biocompatible, but biofunctional conducting material platforms. For their true potential to be reached, it is critical to integrate organic conductors with other biopolymers in a targeted manner, allowing the development of devices and scaffold architectures capable of delivering a number of physical, chemical, and electrical stimuli. Herein, we provide an overview of the methods currently being employed to tailor organic conductors for bioapplications, with a focus on the development of fabrication techniques vital to the development of the next generation of intelligent bionic devices.

  16. Mechanical Systems Development and Integration for a Second Generation Robot Submarine.

    Science.gov (United States)

    1980-05-01

    8217 . . . . . . . . *,t’ " ’ i .* *....",*, *" -2- MECHANICAL SYSTEMS DEVELOPMENT AND INTEGRATION FOR A SECOND GEERATION ROBOT SUBMARINE by James William White...became a cooperative effort. The mounting of the electronics V . 4-15- 02 6- 0 2 0 0o i i i 00 $I 1 I I 0 0r-4 Cto Z * Co .14 00 > z o 0. 0 .U...150 psi capacity. The valve is normally closed so it only requires power when it is -24- 0 ( z rz4 Sd -25- being used. in order to provide a fail safe

  17. Design and System Analysis of Quad-Generation Plant Based on Biomass Gasification Integrated with District Heating

    DEFF Research Database (Denmark)

    Rudra, Souman

    . Different biomass resources are used to generate heat and electricity, to produce gas fuel like bio-SNG (synthesis natural gas) and also to produce liquid fuels, such as ethanol, and biodiesel. Due to the fact that the trend of establishing new and modern plants for handling and processing biomass......This thesis presents the development of energy system for simulation, techno-economic optimization and design of a quad-generation energy system based on biomass gasification. An efficient way of reducing CO2 emission from the environment is by increasing the use of biomass in the energy sector......, it possible to lay a foundation for future gasification based power sector to produce flexible output such as electricity, heat, chemicals or bio-fuels by improving energy system of existing DHP(district heating plant) integrating gasification technology. The present study investigate energy system...

  18. Eastern Renewable Generation Integration Study: Flexibility and High Penetrations of Wind and Solar; NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    Bloom, Aaron; Townsend, Aaron; Palchak, David

    2015-07-29

    Balancing wind and solar in a model is relatively easy. All you need to do is assume a very large system with infinite flexibility! But what if you don't have an infinitely flexible system? What if there are thousands of generators nestled in a handful of regions that are unlikely to change their operational practices? Would you still have enough flexibility to balance hundreds of gigawatts of wind and solar at a 5 minute level? At NREL, we think we can, and our industry partners agree. This presentation was presented at the IEEE Power and Energy Society General Meeting by Aaron Bloom, highlighting results of the Eastern Renewable Generation Integration Study.

  19. Press fluid pre-treatment optimisation of the integrated generation of solid fuel and biogas from biomass (IFBB) process approach.

    Science.gov (United States)

    Corton, John; Toop, Trisha; Walker, Jonathan; Donnison, Iain S; Fraser, Mariecia D

    2014-10-01

    The integrated generation of solid fuel and biogas from biomass (IFBB) system is an innovative approach to maximising energy conversion from low input high diversity (LIHD) biomass. In this system water pre-treated and ensiled LIHD biomass is pressed. The press fluid is anaerobically digested to produce methane that is used to power the process. The fibrous fraction is densified and then sold as a combustion fuel. Two process options designed to concentrate the press fluid were assessed to ascertain their influence on productivity in an IFBB like system: sedimentation and the omission of pre-treatment water. By concentrating press fluid and not adding water during processing, energy production from methane was increased by 75% per unit time and solid fuel productivity increased by 80% per unit of fluid produced. The additional energy requirements for pressing more biomass in order to generate equal volumes of feedstock were accounted for in these calculations.

  20. Wind power integration into the automatic generation control of power systems with large-scale wind power

    DEFF Research Database (Denmark)

    Basit, Abdul; Hansen, Anca Daniela; Altin, Müfit

    2014-01-01

    Transmission system operators have an increased interest in the active participation of wind power plants (WPP) in the power balance control of power systems with large wind power penetration. The emphasis in this study is on the integration of WPPs into the automatic generation control (AGC......) of the power system. The present paper proposes a coordinated control strategy for the AGC between combined heat and power plants (CHPs) and WPPs to enhance the security and the reliability of a power system operation in the case of a large wind power penetration. The proposed strategy, described...... and exemplified for the future Danish power system, takes the hour-ahead regulating power plan for generation and power exchange with neighbouring power systems into account. The performance of the proposed strategy for coordinated secondary control is assessed and discussed by means of simulations for different...

  1. The role of antiepileptic drugs in free radicals generation and antioxidant levels in epileptic patients.

    Science.gov (United States)

    Eldin, Essam Eldin Mohamed Nour; Elshebiny, Hosam Abdel-Fattah; Mohamed, Tarek Mostafa; Abdel-Aziz, Mohamed Abdel-Azim; El-Readi, Mahmoud Zaki

    2016-01-01

    Many risk factors are encountered during the pathogenesis of epilepsy. In this study, the effect of seizure frequency on free radical generation and antioxidants levels in epileptic patients was evaluated. This study was carried out on 15 healthy controls (GI) and 60 epileptic patients treated with mono- or poly-therapy of carbamazepine, valproic acid, or phenytoin. The treated epileptic patients were divided into 2 main groups according to the seizure frequency: controlled seizure patients GII (n = 30) and uncontrolled seizure patients GIII (n = 30). GII included the GIIA subgroup (n = 15) which had been seizure free for more than 12 months and the GIIB subgroup (n = 15) which had been seizure free for a period from 6 to12 months. GIII included GIIIA (n = 15) and GIIIB (n = 15) for patients which had a seizure frequency of less than and more than four times/month, respectively. In comparison to the control group (GI), the levels of nitric oxide (NO) and malondialdehyde/creatinine ratio were significantly increased in GIIB, GIIIA, and GIIIB, while vitamins A and E levels were significantly decreased in GIIIB. Serum NO levels had significant negative correlations with serum vitamin E in the GIIA and GIIB groups, and with vitamin A in the GIIIA and GIIIB groups. However, serum NO had positive correlation with urinary MDA/Cr ratio. The imbalance between free radical generation and antioxidant system in epileptic patients may be a factor in seizure frequency.

  2. Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.B11

    Directory of Open Access Journals (Sweden)

    Susanne K. Hansen

    2016-05-01

    Full Text Available Spinocerebellar ataxia type 3 (SCA3 is a dominantly inherited neurodegenerative disease caused by an expansion of the CAG-repeat in ATXN3. In this study, induced pluripotent stem cells (iPSCs were generated from SCA3 patient dermal fibroblasts by electroporation with episomal plasmids encoding L-MYC, LIN28, SOX2, KLF4, OCT4 and short hairpin RNA targeting P53. The resulting iPSCs had normal karyotype, were free of integrated episomal plasmids, expressed pluripotency markers, could differentiate into the three germ layers in vitro and retained the disease-causing ATXN3 mutation. Potentially, this iPSC line could be a useful tool for the investigation of SCA3 disease mechanisms.

  3. Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.A11

    Directory of Open Access Journals (Sweden)

    Susanne K. Hansen

    2016-05-01

    Full Text Available Spinocerebellar ataxia type 3 (SCA3 is a dominantly inherited neurodegenerative disease caused by a CAG-repeat expanding mutation in ATXN3. We generated induced pluripotent stem cells (iPSCs from a SCA3 patient by electroporation of dermal fibroblasts with episomal plasmids encoding L-MYC, LIN28, SOX2, KLF4, OCT4 and short hairpin RNA targeting P53. The resulting iPSCs had normal karyotype, were free of genomically integrated episomal plasmids, expressed pluripotency markers, could differentiate into the three germ layers in vitro and retained the disease-causing ATXN3 mutation. This iPSC line could be useful for the investigation of SCA3 disease mechanisms.

  4. The effectiveness of integrated care for patients with hand eczema: Results of a randomized, controlled trial

    NARCIS (Netherlands)

    Gils, R.F. van; Boot, C.R.L.; Knol, D.L.; Rustemeyer, T.; Mechelen, W. van; Valk, P.G.M. van der; Anema, J.R.

    2012-01-01

    Objectives. To evaluate the effectiveness of integrated, multidisciplinary care as compared with usual care for patients with moderate to severe, chronic hand eczema after 26 weeks of follow-up. Background. This study was designed as a randomized, controlled trial. Methods. Patients who visited one

  5. The effectiveness of integrated care for patients with hand eczema: Results of a randomized, controlled trial

    NARCIS (Netherlands)

    Gils, R.F. van; Boot, C.R.L.; Knol, D.L.; Rustemeyer, T.; Mechelen, W. van; Valk, P.G.M. van der; Anema, J.R.

    2012-01-01

    Objectives. To evaluate the effectiveness of integrated, multidisciplinary care as compared with usual care for patients with moderate to severe, chronic hand eczema after 26 weeks of follow-up. Background. This study was designed as a randomized, controlled trial. Methods. Patients who visited one

  6. Optical pulse shaper with integrated slab waveguide for arbitrary waveform generation using optical gradient force

    Science.gov (United States)

    Liao, Sha-Sha; Min, Shu-Cun; Dong, Jian-Ji

    2014-12-01

    Integrated optical pulse shaper opens up possibilities for realizing the ultra high-speed and ultra wide-band linear signal processing with compact size and low power consumption. We propose a silicon monolithic integrated optical pulse shaper using optical gradient force, which is based on the eight-path finite impulse response. A cantilever structure is fabricated in one arm of the Mach—Zehnder interferometer (MZI) to act as an amplitude modulator. The phase shift feature of waveguide is analyzed with the optical pump power, and five typical waveforms are demonstrated with the manipulation of optical force. Unlike other pulse shaper schemes based on thermo—optic effect or electro—optic effect, our scheme is based on a new degree of freedom manipulation, i.e., optical force, so no microelectrodes are required on the silicon chip, which can reduce the complexity of fabrication. Besides, the chip structure is suitable for commercial silicon on an insulator (SOI) wafer, which has a top silicon layer of about 220 nm in thickness.

  7. Streamline integration as a method for two-dimensional elliptic grid generation

    CERN Document Server

    Wiesenberger, Matthias; Einkemmer, Lukas

    2016-01-01

    We propose a new numerical algorithm to construct a structured numerical grid of a doubly connected domain that is bounded by the contour lines of a given function. It is based on the integration of the streamlines of the two vector fields that form the basis of the coordinate system. These vector fields are either built directly from the given function or from the solution of a suitably chosen elliptic equation (which can be solved once an initial grid has been constructed). We are able to construct conformal, orthogonal and curvilinear coordinates. The method is parallelizable and the metric elements can be computed with high accuracy. Furthermore, it is easy to implement as only the integration of well-behaved ordinary differential equations and the inversion of a linear elliptic equation are required. All our grids are orthogonal to the boundary of the domain, which is the major advantage over previously suggested grids. We assess the quality of our grids with the solution of an elliptic equation and the ...

  8. Active vortex generator deployed on demand by size independent actuation of shape memory alloy wires integrated in fiber reinforced polymers

    Science.gov (United States)

    Hübler, M.; Nissle, S.; Gurka, M.; Wassenaar, J.

    2016-04-01

    Static vortex generators (VGs) are installed on different aircraft types. They generate vortices and interfuse the slow boundary layer with the fast moving air above. Due to this energizing, a flow separation of the boundary layer can be suppressed at high angles of attack. However the VGs cause a permanently increased drag over the whole flight cycle reducing the cruise efficiency. This drawback is currently limiting the use of VGs. New active VGs, deployed only on demand at low speed, can help to overcome this contradiction. Active hybrid structures, combining the actuation of shape memory alloys (SMA) with fiber reinforced polymers (FRP) on the materials level, provide an actuation principle with high lightweight potential and minimum space requirements. Being one of the first applications of active hybrid structures from SMA and FRP, these active vortex generators help to demonstrate the advantages of this new technology. A new design approach and experimental results of active VGs are presented based on the application of unique design tools and advanced manufacturing approaches for these active hybrid structures. The experimental investigation of the actuation focuses on the deflection potential and the dynamic response. Benchmark performance data such as a weight of 1.5g and a maximum thickness of only 1.8mm per vortex generator finally ensure a simple integration in the wing structure.

  9. A New Method of Reference Signal Generation Applied To UPQC-PHEV For Grid Integration of WECS-SCIG

    Directory of Open Access Journals (Sweden)

    Girish B M

    2017-02-01

    Full Text Available In this paper a new reference signal generation control technique is proposed for integration of Unified Power Quality Conditioner (UPQC with Plug-in Hybrid Electric Vehicle (PHEV for overcoming voltage sag and other voltage fault conditions on wind farms which is connected to grid. The interaction of wind generators and grid causes increased short circuit current which leads to instability during fault conditions. The new control technique which generate reference signals for series active power filter (Series APF and shunt active power filter (Shunt APF of UPQC by using PHEV as an Energy Storage System (ESS which will take care of all types of voltage faults occurred in the system and provide energy storage to DC link between Series APF and Shunt APF parts of UPQC. The control scheme proposed also maintains transaction of active and reactive power of Wind Energy Conversion System based on Squirrel Cage Induction Generators (WECS-SCIG and grid. The fuzzy logic provides fast and dynamic response to clear faults occurred in the system.

  10. Generation IV Reactors Integrated Materials Technology Program Plan: Focus on Very High Temperature Reactor Materials

    Energy Technology Data Exchange (ETDEWEB)

    Corwin, William R [ORNL; Burchell, Timothy D [ORNL; Katoh, Yutai [ORNL; McGreevy, Timothy E [ORNL; Nanstad, Randy K [ORNL; Ren, Weiju [ORNL; Snead, Lance Lewis [ORNL; Wilson, Dane F [ORNL

    2008-08-01

    Since 2002, the Department of Energy's (DOE's) Generation IV Nuclear Energy Systems (Gen IV) Program has addressed the research and development (R&D) necessary to support next-generation nuclear energy systems. The six most promising systems identified for next-generation nuclear energy are described within this roadmap. Two employ a thermal neutron spectrum with coolants and temperatures that enable hydrogen or electricity production with high efficiency (the Supercritical Water Reactor-SCWR and the Very High Temperature Reactor-VHTR). Three employ a fast neutron spectrum to enable more effective management of actinides through recycling of most components in the discharged fuel (the Gas-cooled Fast Reactor-GFR, the Lead-cooled Fast Reactor-LFR, and the Sodium-cooled Fast Reactor-SFR). The Molten Salt Reactor (MSR) employs a circulating liquid fuel mixture that offers considerable flexibility for recycling actinides and may provide an alternative to accelerator-driven systems. At the inception of DOE's Gen IV program, it was decided to significantly pursue five of the six concepts identified in the Gen IV roadmap to determine which of them was most appropriate to meet the needs of future U.S. nuclear power generation. In particular, evaluation of the highly efficient thermal SCWR and VHTR reactors was initiated primarily for energy production, and evaluation of the three fast reactor concepts, SFR, LFR, and GFR, was begun to assess viability for both energy production and their potential contribution to closing the fuel cycle. Within the Gen IV Program itself, only the VHTR class of reactors was selected for continued development. Hence, this document will address the multiple activities under the Gen IV program that contribute to the development of the VHTR. A few major technologies have been recognized by DOE as necessary to enable the deployment of the next generation of advanced nuclear reactors, including the development and qualification of

  11. Influence of Resolution of the Input Data on Distributed Generation Integration Studies

    DEFF Research Database (Denmark)

    Ciontea, Catalin-Iosif; Sera, Dezso; Iov, Florin

    2014-01-01

    the evaluation procedure of the voltage fluctuations and no directions regarding the sampling frequency of the data used. As a consequence, most of the studies neglect effect of the solar irradiance and wind speed in fast changing conditions on the utility grid. This work proposes a methodology to evaluate...... the voltage fluctuations into the low voltage distribution network caused by variable generation and reveals the influence of data resolution on the final results. A short review regarding the assessment of the voltage variations is presented in advance and an appropriate model of the power system is build...

  12. Enabling CCS via Low-temperature Geothermal Energy Integration for Fossil-fired Power Generation

    Energy Technology Data Exchange (ETDEWEB)

    Davidson, C. L.; Heldebrant, D. J.; Bearden, M. D.; Horner, J. A.; Freeman, C. J.

    2017-07-01

    Among the key barriers to commercial scale deployment is the cost associated with CO2 capture. This is particularly true for existing large, fossil-fired assets that account for a large fraction of the electricity generation fleet in developed nations, including the U.S. Fitting conventional combustion technologies with CO2 capture systems can carry an energy penalty of thirty percent or more, resulting in an increased price of power to the grid, as well as an overall decrease in net plant output. Taken together with the positive growth in demand for electricity, this implies a need for accelerated capital build-out in the power generation markets to accommodate both demand growth and decreased output at retrofitted plants. In this paper, the authors present the results of a study to assess the potential to use geothermal energy to provide boiler feedwater preheating, capturing efficiency improvements designed to offset the losses associated with CO2 capture. Based on NETL benchmark cases and subsequent analysis of the application using site-specific data from the North Valmy power plant, several cases for CO2 capture were evaluated. These included geothermally assisted MEA capture, CO2BOLs capture, and stand-alone hybrid power generation, compared with a baseline, no-geothermal case. Based on Case 10, and assuming 2.7 MMlb/h of geothermally sourced 150 ºC water, the parasitic power load associated with MEA capture could be offset by roughly seven percent, resulting in a small (~1 percent) overall loss to net power generation, but at levelized costs of electricity similar to the no-geothermal CCS case. For the CO2BOLs case, the availability of 150°C geothermal fluid could allow the facility to not only offset the net power decrease associated with CO2BOLs capture alone, but could increase nameplate capacity by two percent. The geothermally coupled CO2BOLs case also decreases LCOE by 0.75 ¢/kWh relative to the non-hybrid CO2BOLs case, with the improved

  13. Unit commitment with wind power generation: integrating wind forecast uncertainty and stochastic programming.

    Energy Technology Data Exchange (ETDEWEB)

    Constantinescu, E. M.; Zavala, V. M.; Rocklin, M.; Lee, S.; Anitescu, M. (Mathematics and Computer Science); (Univ. of Chicago); (New York Univ.)

    2009-10-09

    We present a computational framework for integrating the state-of-the-art Weather Research and Forecasting (WRF) model in stochastic unit commitment/energy dispatch formulations that account for wind power uncertainty. We first enhance the WRF model with adjoint sensitivity analysis capabilities and a sampling technique implemented in a distributed-memory parallel computing architecture. We use these capabilities through an ensemble approach to model the uncertainty of the forecast errors. The wind power realizations are exploited through a closed-loop stochastic unit commitment/energy dispatch formulation. We discuss computational issues arising in the implementation of the framework. In addition, we validate the framework using real wind speed data obtained from a set of meteorological stations. We also build a simulated power system to demonstrate the developments.

  14. Hundred-Watt-Level, All-Fiber-Integrated Supercontinuum Generation from Photonic Crystal Fiber

    Science.gov (United States)

    Chen, Hongwei; Chen, Zilun; Chen, Shengping; Hou, Jing; Lu, Qisheng

    2013-03-01

    A photonic crystal fiber (PCF) based supercontinuum source with hundred-watt-level average power output is presented in this paper. The output delivery fiber of a 120 W picosecond master-oscillator power-amplifier (MOPA) laser with a 15 µm fiber core is directly spliced with a 2.6-m-long PCF to form the all-fiber-integrated SC source. Using the controlled air-hole collapse technique to expand the core diameter of the PCF, a super-low splice loss (˜0.2 dB) between the delivery fiber and the PCF has been demonstrated. A 92.5 W SC spanning from about 700 nm to beyond 1700 nm is obtained.

  15. Does social dominance generate prejudice? Integrating individual and contextual determinants of intergroup cognitions.

    Science.gov (United States)

    Guimond, Serge; Dambrun, Michaël; Michinov, Nicolas; Duarte, Sandra

    2003-04-01

    Social dominance orientation (SDO) has been proposed as an important variable in the explanation of prejudice. We distinguish between three conceptualizations of SDO: SDO as a personality trait (personality model), SDO as a moderator of the effects of situational variables (Person x Situation model), and SDO as a mediator of the effect of social position on prejudice (group socialization model [GSM]). Four studies (N = 1.657) looking at the relations between social positions, SDO, and prejudice in a natural setting and in a laboratory setting provide strong support for the GSM. In contrast to previous correlational findings, there is evidence of a cause (dominant social position), an effect (prejudice increases), and a mediator (SDO). These results suggest new perspectives on the integration of individual and contextual determinants of prejudice.

  16. Policy schemes, operational strategies and system integration of residential co-generation fuel cells

    DEFF Research Database (Denmark)

    Hansen, Lise-Lotte Pade; Schröder, Sascha Thorsten; Münster, Marie

    2013-01-01

    This study presents a holistic approach for the commercialisation of fuel cells for stationary applications. We focus our analyses on microCHP based on SOFC units fired with natural gas. We analyse the interaction of operational strategies under different ownership arrangements, required support...... levels and system integration aspects. The operational strategies, support mechanisms and ownership arrangements have been identified through actor analysis involving experts from Denmark, France and Portugal. With regard to operational strategies, the actor analyses led us to distinguishing between...... a heat-driven strategy, with and without time-differentiated tariffs, and an electricity price driven strategy for the operation as a virtual power plant. The corresponding support schemes identified cover feed-in tariffs, net metering and feed-in premiums. Additionally, the interplay of the micro...

  17. Investigation of the pressure generated in the mould cavity during polyurethane integral skin foam moulding

    Directory of Open Access Journals (Sweden)

    2008-07-01

    Full Text Available An industrial scale measuring system was set up to investigate the pressure arising in the mould cavity during polyurethane integral skin foaming. The system is able to measure the pressure arising in the mould cavity and the pressure distribution using a piezoresistive pressure sensor. The pressure distribution was measured at 18 points along the mould surface at constant production parameters. Then six production parameters, which affect the pressure, were investigated in detail with the Taguchi method of experimental design. The results of the design were processed by ANOVA (analysis of variance. Three major influencing parameters were estimated by regression analysis. Finally an equation was developed to give a good estimation to the pressure arising in the mould cavity.

  18. Large-scale integrated super-computing platform for next generation virtual drug discovery.

    Science.gov (United States)

    Mitchell, Wayne; Matsumoto, Shunji

    2011-08-01

    Traditional drug discovery starts by experimentally screening chemical libraries to find hit compounds that bind to protein targets, modulating their activity. Subsequent rounds of iterative chemical derivitization and rescreening are conducted to enhance the potency, selectivity, and pharmacological properties of hit compounds. Although computational docking of ligands to targets has been used to augment the empirical discovery process, its historical effectiveness has been limited because of the poor correlation of ligand dock scores and experimentally determined binding constants. Recent progress in super-computing, coupled to theoretical insights, allows the calculation of the Gibbs free energy, and therefore accurate binding constants, for usually large ligand-receptor systems. This advance extends the potential of virtual drug discovery. A specific embodiment of the technology, integrating de novo, abstract fragment based drug design, sophisticated molecular simulation, and the ability to calculate thermodynamic binding constants with unprecedented accuracy, are discussed. Copyright © 2011 Elsevier Ltd. All rights reserved.

  19. Very high speed integrated circuits - Into the second generation. I - The birth of a program

    Science.gov (United States)

    Martin, J.

    1981-12-01

    A development program for very high speed integrated circuits (VHSIC) for DOD applications is discussed. The advent of Soviet 16K RAM chips two years after the U.S. led to a three phase U.S. program to define VHSIC configurations, architecture, and testing, and provide pilot production of radiation-hardened chips. Another phase will lead to submicron ICs with a gate-clock frequency product of more than 10 billion gate-Hz/sq cm, with a minimum chip clock rate of 100 MHz. A further phase involves research support to universities. Electron beam lithography receives the greatest efforts, having alignment accuracies of 0.5 micron. Congressional discussions for funding are reviewed, noting the cancellation of GaAs research to avoid conflicts with DARPA research, and attention is paid to the effects of a centralized research program responsive to the DOD, instead of separate programs for each service branch.

  20. Integrating the protein and metabolic engineering toolkits for next-generation chemical biosynthesis.

    Science.gov (United States)

    Pirie, Christopher M; De Mey, Marjan; Jones Prather, Kristala L; Ajikumar, Parayil Kumaran

    2013-04-19

    Through microbial engineering, biosynthesis has the potential to produce thousands of chemicals used in everyday life. Metabolic engineering and synthetic biology are fields driven by the manipulation of genes, genetic regulatory systems, and enzymatic pathways for developing highly productive microbial strains. Fundamentally, it is the biochemical characteristics of the enzymes themselves that dictate flux through a biosynthetic pathway toward the product of interest. As metabolic engineers target sophisticated secondary metabolites, there has been little recognition of the reduced catalytic activity and increased substrate/product promiscuity of the corresponding enzymes compared to those of central metabolism. Thus, fine-tuning these enzymatic characteristics through protein engineering is paramount for developing high-productivity microbial strains for secondary metabolites. Here, we describe the importance of protein engineering for advancing metabolic engineering of secondary metabolism pathways. This pathway integrated enzyme optimization can enhance the collective toolkit of microbial engineering to shape the future of chemical manufacturing.

  1. Predictions of structural integrity of steam generator tubes under normal operating, accident, an severe accident conditions

    Energy Technology Data Exchange (ETDEWEB)

    Majumdar, S. [Argonne National Lab., IL (United States)

    1997-02-01

    Available models for predicting failure of flawed and unflawed steam generator tubes under normal operating, accident, and severe accident conditions are reviewed. Tests conducted in the past, though limited, tended to show that the earlier flow-stress model for part-through-wall axial cracks overestimated the damaging influence of deep cracks. This observation was confirmed by further tests at high temperatures, as well as by finite-element analysis. A modified correlation for deep cracks can correct this shortcoming of the model. Recent tests have shown that lateral restraint can significantly increase the failure pressure of tubes with unsymmetrical circumferential cracks. This observation was confirmed by finite-element analysis. The rate-independent flow stress models that are successful at low temperatures cannot predict the rate-sensitive failure behavior of steam generator tubes at high temperatures. Therefore, a creep rupture model for predicting failure was developed and validated by tests under various temperature and pressure loadings that can occur during postulated severe accidents.

  2. Integration of Variable Speed Pumped Hydro Storage in Automatic Generation Control Systems

    Science.gov (United States)

    Fulgêncio, N.; Moreira, C.; Silva, B.

    2017-04-01

    Pumped storage power (PSP) plants are expected to be an important player in modern electrical power systems when dealing with increasing shares of new renewable energies (NRE) such as solar or wind power. The massive penetration of NRE and consequent replacement of conventional synchronous units will significantly affect the controllability of the system. In order to evaluate the capability of variable speed PSP plants participation in the frequency restoration reserve (FRR) provision, taking into account the expected performance in terms of improved ramp response capability, a comparison with conventional hydro units is presented. In order to address this issue, a three area test network was considered, as well as the corresponding automatic generation control (AGC) systems, being responsible for re-dispatching the generation units to re-establish power interchange between areas as well as the system nominal frequency. The main issue under analysis in this paper is related to the benefits of the fast response of variable speed PSP with respect to its capability of providing fast power balancing in a control area.

  3. Integration of Thermoelectric Generators and Wood Stove to Produce Heat, Hot Water, and Electrical Power

    Science.gov (United States)

    Goudarzi, A. M.; Mazandarani, P.; Panahi, R.; Behsaz, H.; Rezania, A.; Rosendahl, L. A.

    2013-07-01

    Traditional fire stoves are characterized by low efficiency. In this experimental study, the combustion chamber of the stove is augmented by two devices. An electric fan can increase the air-to-fuel ratio in order to increase the system's efficiency and decrease air pollution by providing complete combustion of wood. In addition, thermoelectric generators (TEGs) produce power that can be used to satisfy all basic needs. In this study, a water-based cooling system is designed to increase the efficiency of the TEGs and also produce hot water for residential use. Through a range of tests, an average of 7.9 W was achieved by a commercial TEG with substrate area of 56 mm × 56 mm, which can produce 14.7 W output power at the maximum matched load. The total power generated by the stove is 166 W. Also, in this study a reasonable ratio of fuel to time is described for residential use. The presented prototype is designed to fulfill the basic needs of domestic electricity, hot water, and essential heat for warming the room and cooking.

  4. The One-Water Hydrologic Flow Model - The next generation in fully integrated hydrologic simulation software

    Science.gov (United States)

    Boyce, S. E.; Hanson, R. T.

    2015-12-01

    The One-Water Hydrologic Flow Model (MF-OWHM) is a MODFLOW-based integrated hydrologic flow model that is the most complete version, to date, of the MODFLOW family of hydrologic simulators needed for the analysis of a broad range of conjunctive-use issues. MF-OWHM fully links the movement and use of groundwater, surface water, and imported water for consumption by agriculture and natural vegetation on the landscape, and for potable and other uses within a supply-and-demand framework. MF-OWHM is based on the Farm Process for MODFLOW-2005 combined with Local Grid Refinement, Streamflow Routing, Surface-water Routing Process, Seawater Intrusion, Riparian Evapotranspiration, and the Newton-Raphson solver. MF-OWHM also includes linkages for deformation-, flow-, and head-dependent flows; additional observation and parameter options for higher-order calibrations; and redesigned code for facilitation of self-updating models and faster simulation run times. The next version of MF-OWHM, currently under development, will include a new surface-water operations module that simulates dynamic reservoir operations, the conduit flow process for karst aquifers and leaky pipe networks, a new subsidence and aquifer compaction package, and additional features and enhancements to enable more integration and cross communication between traditional MODFLOW packages. By retaining and tracking the water within the hydrosphere, MF-OWHM accounts for "all of the water everywhere and all of the time." This philosophy provides more confidence in the water accounting by the scientific community and provides the public a foundation needed to address wider classes of problems such as evaluation of conjunctive-use alternatives and sustainability analysis, including potential adaptation and mitigation strategies, and best management practices. By Scott E. Boyce and Randall T. Hanson

  5. Generation of integral experiment covariance data and their impact on criticality safety validation

    Energy Technology Data Exchange (ETDEWEB)

    Stuke, Maik; Peters, Elisabeth; Sommer, Fabian

    2016-11-15

    The quantification of statistical dependencies in data of critical experiments and how to account for them properly in validation procedures has been discussed in the literature by various groups. However, these subjects are still an active topic in the Expert Group on Uncertainty Analysis for Criticality Safety Assessment (UACSA) of the OECDNEA Nuclear Science Committee. The latter compiles and publishes the freely available experimental data collection, the International Handbook of Evaluated Criticality Safety Benchmark Experiments, ICSBEP. Most of the experiments were performed as series and share parts of experimental setups, consequently leading to correlation effects in the results. The correct consideration of correlated data seems to be inevitable if the experimental data in a validation procedure is limited or one cannot rely on a sufficient number of uncorrelated data sets, e.g. from different laboratories using different setups. The general determination of correlations and the underlying covariance data as well as the consideration of them in a validation procedure is the focus of the following work. We discuss and demonstrate possible effects on calculated k{sub eff}'s, their uncertainties, and the corresponding covariance matrices due to interpretation of evaluated experimental data and its translation into calculation models. The work shows effects of various modeling approaches, varying distribution functions of parameters and compares and discusses results from the applied Monte-Carlo sampling method with available data on correlations. Our findings indicate that for the reliable determination of integral experimental covariance matrices or the correlation coefficients a detailed study of the underlying experimental data, the modeling approach and assumptions made, and the resulting sensitivity analysis seems to be inevitable. Further, a Bayesian method is discussed to include integral experimental covariance data when estimating an

  6. The Use of Integrative Therapies in Patients with Amyotrophic Lateral Sclerosis in Shanghai, China

    OpenAIRE

    Weidong Pan; Xiangjun Chen; Jie Bao; Yu Bai; Hua Lu; Qiudong Wang; Yi Liu; Canxing Yuan; Wenwei Li; Zhenguo Liu; Jun Liu; Xuying Zhu; Baofeng Qin; Dingfang Cai; Hua Zhou

    2013-01-01

    Objective. To investigate the current use of integrative therapies (IT) in the treatment of patients with amyotrophic lateral sclerosis (ALS). Methods. A cross-sectional, multicenter clinical epidemiological survey was conducted in 12 hospitals in Shanghai. We investigated the type and frequency of IT use and determined whether the use of IT correlated with demographic, social, or disease-specific characteristics in our patient population. Results. A total of 231 (89.5%) of 258 patients with ...

  7. Integration of Hybrid PV/Wind Generation System Using Fuzzy MPPT in Grid Connected System for Remote Area

    Directory of Open Access Journals (Sweden)

    Soedibyo

    2016-01-01

    Full Text Available Photovoltaic and wind are renewable energy resources that widely used and grow rapidly in fulfilling electricity demand. Powers from both technologies depend on sunlight intensity and wind speed. For small scale power generation, DC voltage from both technologies is low and requires step-up converter to raise DC voltage ratio before converted into AC voltage. To optimize this system, step-up converter must have high ratio and efficiency to a distance of wide voltage input. This paper proposed an operation simulation and arrangement of DC-DC converter along with DC-AC from hybrid source PV-Wind which integrated to grid utilities without using storage device. High Gain Integrated Cascade Boost (HGICB is DC-DC converter that has quadratic voltage ratio and used in this research. Then DC link connected to Voltage Source Inverter (VSI which interconnected with utility grid and controlled by current control method. The total installed capacity of hybrid source is 4.4 kW. Wind turbine uses PMSG along with full bridge rectifier. To maximize and stabilize the generated power, MPPT fuzzy is used. Result from the simulation shows that converter capable to maintain maximum power whether from PV and wind turbine which canalized to utility grid in various irradiation condition, wind speed, and grid load alteration.

  8. Model-based automatic 3d building model generation by integrating LiDAR and aerial images

    Science.gov (United States)

    Habib, A.; Kwak, E.; Al-Durgham, M.

    2011-12-01

    Accurate, detailed, and up-to-date 3D building models are important for several applications such as telecommunication network planning, urban planning, and military simulation. Existing building reconstruction approaches can be classified according to the data sources they use (i.e., single versus multi-sensor approaches), the processing strategy (i.e., data-driven, model-driven, or hybrid), or the amount of user interaction (i.e., manual, semiautomatic, or fully automated). While it is obvious that 3D building models are important components for many applications, they still lack the economical and automatic techniques for their generation while taking advantage of the available multi-sensory data and combining processing strategies. In this research, an automatic methodology for building modelling by integrating multiple images and LiDAR data is proposed. The objective of this research work is to establish a framework for automatic building generation by integrating data driven and model-driven approaches while combining the advantages of image and LiDAR datasets.

  9. Integration of an advanced sealed-tube neutron generator into a mobile neutron radiology system and resulting performance

    Science.gov (United States)

    Dance, William E.; Cluzeau, Serge; Mast, Hans-Ulrich

    1991-05-01

    The first DIANE ∗ neutron radiology system is being prepared for operation in the IABG laboratories in Ottobrunn (Germany). It utilizes a new D-T generator, designated GENIE 46, developed by SODERN (France) for this application. The generator is being integrated into an upgraded LTV-produced mobile neutron radiology system suitable for practical nonreactor inspection of components and structures. The maximum output of the present version of the GENIE 46 is 5 × 10 11 n s -1 (14 MeV) with less than 10 mA ion beam current at 225 kV. Tube lifetime at maximum output is approximately 500 h, while at 10 11 n s -1 the tube is designed for a lifetime of 1500 h. The geometry of the neutron tube, VHV connectors, ion source power supply, and cooling tubes comprises a cannister designed to be compatible with the 10-in. diameter opening in the LTV moderator/collimator assembly. 3-D Monte Carlo neutron/photon transport simulations of the new integrated radiology system operation have been performed by IABG. The calculations predict a thermal neutron flux at the collimator exit ( {L}/{D} = 13) of φth(0 ≤ En ≤ 0.3 eV) = 1.2 × 10 5 n cm -2 s -1. Comparisons of this value and other Monte Carlo results with actual performance will be made in the near future with the accrual of operational data.

  10. An effective algorithm for the generation of patient-specific Purkinje networks in computational electrocardiology

    Science.gov (United States)

    Palamara, Simone; Vergara, Christian; Faggiano, Elena; Nobile, Fabio

    2015-02-01

    The Purkinje network is responsible for the fast and coordinated distribution of the electrical impulse in the ventricle that triggers its contraction. Therefore, it is necessary to model its presence to obtain an accurate patient-specific model of the ventricular electrical activation. In this paper, we present an efficient algorithm for the generation of a patient-specific Purkinje network, driven by measures of the electrical activation acquired on the endocardium. The proposed method provides a correction of an initial network, generated by means of a fractal law, and it is based on the solution of Eikonal problems both in the muscle and in the Purkinje network. We present several numerical results both in an ideal geometry with synthetic data and in a real geometry with patient-specific clinical measures. These results highlight an improvement of the accuracy provided by the patient-specific Purkinje network with respect to the initial one. In particular, a cross-validation test shows an accuracy increase of 19% when only the 3% of the total points are used to generate the network, whereas an increment of 44% is observed when a random noise equal to 20% of the maximum value of the clinical data is added to the measures.

  11. Identification of mechanisms enabling integrated care for patients with chronic diseases: a literature review

    Directory of Open Access Journals (Sweden)

    Denise van der Klauw

    2014-07-01

    Full Text Available Introduction: Notwithstanding care for chronically ill patients requires a shift towards care that is well coordinated and focused on prevention and self-care, the concept of integrated care lacks specificity and clarity. This article presents a literature review to identify mechanisms for achieving integrated care objectives. Theory and methods: Existing models often present a large variety of dimensions, archetypes and categories of integration without specifying them. Models and programmes describing integrated care for chronic diseases were reviewed. Data were extracted related to objectives and clusters of mechanisms of integration. Results: Thirty-four studies presented four objectives: functional, organisational, professional and service integration. We categorised approaches and interventions to achieve these objectives by strategy and clusters of ‘mechanisms of integration’: degree, patient centredness and normative aspects. Conclusions and discussion: The clarification of mechanisms to achieve objectives of integrated care as presented may be used as starting point for the development and refinement of integrated care programmes, including methodological grounding of their evaluation. Given that most studies reviewed lack both empirical data and descriptions of the methods used, future research needs to close these gaps. Validation of the findings by a large panel of experts is suggested as recommendation to work towards a grounded framework.

  12. Identification of mechanisms enabling integrated care for patients with chronic diseases: a literature review

    Directory of Open Access Journals (Sweden)

    Denise van der Klauw

    2014-07-01

    Full Text Available Introduction: Notwithstanding care for chronically ill patients requires a shift towards care that is well coordinated and focused on prevention and self-care, the concept of integrated care lacks specificity and clarity. This article presents a literature review to identify mechanisms for achieving integrated care objectives.Theory and methods: Existing models often present a large variety of dimensions, archetypes and categories of integration without specifying them. Models and programmes describing integrated care for chronic diseases were reviewed. Data were extracted related to objectives and clusters of mechanisms of integration.Results: Thirty-four studies presented four objectives: functional, organisational, professional and service integration. We categorised approaches and interventions to achieve these objectives by strategy and clusters of ‘mechanisms of integration’: degree, patient centredness and normative aspects.Conclusions and discussion: The clarification of mechanisms to achieve objectives of integrated care as presented may be used as starting point for the development and refinement of integrated care programmes, including methodological grounding of their evaluation. Given that most studies reviewed lack both empirical data and descriptions of the methods used, future research needs to close these gaps. Validation of the findings by a large panel of experts is suggested as recommendation to work towards a grounded framework.

  13. An integrated inspection of the somatic mutations in a lung squamous cell carcinoma using next-generation sequencing.

    Directory of Open Access Journals (Sweden)

    Lucy F Stead

    Full Text Available Squamous cell carcinoma (SCC of the lung kills over 350,000 people annually worldwide, and is the main lung cancer histotype with no targeted treatments. High-coverage whole-genome sequencing of the other main subtypes, small-cell and adenocarcinoma, gave insights into carcinogenic mechanisms and disease etiology. The genomic complexity within the lung SCC subtype, as revealed by The Cancer Genome Atlas, means this subtype is likely to benefit from a more integrated approach in which the transcriptional consequences of somatic mutations are simultaneously inspected. Here we present such an approach: the integrated analysis of deep sequencing data from both the whole genome and whole transcriptome (coding and non-coding of LUDLU-1, a SCC lung cell line. Our results show that LUDLU-1 lacks the mutational signature that has been previously associated with tobacco exposure in other lung cancer subtypes, and suggests that DNA-repair efficiency is adversely affected; LUDLU-1 contains somatic mutations in TP53 and BRCA2, allelic imbalance in the expression of two cancer-associated BRCA1 germline polymorphisms and reduced transcription of a potentially endogenous PARP2 inhibitor. Functional assays were performed and compared with a control lung cancer cell line. LUDLU-1 did not exhibit radiosensitisation or an increase in sensitivity to PARP inhibitors. However, LUDLU-1 did exhibit small but significant differences with respect to cisplatin sensitivity. Our research shows how integrated analyses of high-throughput data can generate hypotheses to be tested in the lab.

  14. Research on Integration of an Automotive Exhaust-Based Thermoelectric Generator and a Three-Way Catalytic Converter

    Science.gov (United States)

    Deng, Y. D.; Chen, Y. L.; Chen, S.; Xianyu, W. D.; Su, C. Q.

    2015-06-01

    A key research topic related to thermoelectric generators (TEGs) for automotive applications is to improve their compatibility with the original vehicle exhaust system, which determines the quality of the exhaust gas treatment and the realization of energy conservation and emission reduction. A new TEG integrated with a three-way catalytic converter (CTEG) by reshaping the converter as the heat exchanger is proposed. A heat-flux coupling simulation model of the integrated TEG is established at the light-off stage of the original three-way catalytic converter (TWC). Temperature distribution maps of the integrated heat exchanger, thermoelectric modules, and cooling-water tank are obtained to present the process of energy flow among the parts of the CTEG. Based on the simulation results, the output power of the CTEG is calculated by a mathematical model. A minimum output power of 31.93 W can be obtained by conversion when the TWC starts working at steady conditions. Theoretically, this case study demonstrates the great potential for use of CTEGs in vehicles.

  15. EIRP Characterization of Electrically Large Wireless Equipment with Integrated Signal Generator in a Compact Environment

    Directory of Open Access Journals (Sweden)

    Soon-Soo Oh

    2015-01-01

    Full Text Available We describe a measurement technique to characterize the equivalent isotropically radiated power (EIRP of electrically large wireless equipment in a compact environment. A modified phase-measurement method was proposed and, thus, the separation of the signal generator and radiating element was not required during the measurement. A Fresnel-to-far-field transformation was used for the fast measurement time in a compact anechoic chamber. An experimental verification of the method was carried out in a compact anechoic chamber, where the source-detector separation was approximately 1/5 of the far-field distance. The measured magnitude and phase pattern exhibited only a small error. The EIRP obtained using a Fresnel-to-far-field transformation was compared with a reference value, and the error was within 0.5 dB.

  16. Solution of wind integrated thermal generation system for environmental optimal power flow using hybrid algorithm

    Directory of Open Access Journals (Sweden)

    Ambarish Panda

    2016-09-01

    Full Text Available A new evolutionary hybrid algorithm (HA has been proposed in this work for environmental optimal power flow (EOPF problem. The EOPF problem has been formulated in a nonlinear constrained multi objective optimization framework. Considering the intermittency of available wind power a cost model of the wind and thermal generation system is developed. Suitably formed objective function considering the operational cost, cost of emission, real power loss and cost of installation of FACTS devices for maintaining a stable voltage in the system has been optimized with HA and compared with particle swarm optimization algorithm (PSOA to prove its effectiveness. All the simulations are carried out in MATLAB/SIMULINK environment taking IEEE30 bus as the test system.

  17. Ecocide, the integrity of creation and the rights of the next generation

    Directory of Open Access Journals (Sweden)

    J M Vorster

    2005-10-01

    Full Text Available Environmental Ethics is currently a highly important theme in Christian Ethics. This is due to the disturbing results of the current ecological research. Scholars today speak of �ecocide� � a term which describes the on-going destruction of ecosystems by means of pollution, deforestation, modern warfare, toxic waste and the increase in poverty. Of special concern is the accusation that Christianity with its emphasis on the dominium terrae is partly to blame for this state of affairs. This article investigates the magnitude of ecocide as well as the historical influences of Christianity. It focuses on a re-assessment of the Christian approach as well as the responsibilities of governments, educators, churches and corporations to take care of creation and the rights of the future generation.

  18. Antiretroviral treatment among co-infected tuberculosis patients in integrated and non-integrated facilities.

    Science.gov (United States)

    Ledibane, T D; Motlhanke, S C; Rose, A; Kruger, W H; Ledibane, N R T; Claassens, M M

    2015-06-21

    Contexte : L'Afrique du Sud est au deuxième rang dans le monde de la « syndémie » tuberculose/virus d'immunodéficience humaine (TB-VIH) : en 2011, le taux de coïnfection TB-VIH a été estimé à 65%. L'intégration des services de soins de la TB et du VIH a été mise en œuvre pour augmenter la mise sous traitement antirétroviral (ART) chez les patients éligibles.Objectif : Evaluer si les structures intégrant TB et VIH comparées aux structures non-intégrées ont un meilleur taux de prise d'ART parmi les patients éligibles.Méthodes : Etude transversale utilisant les données de routine des programmes TB de janvier à décembre 2010. L'éligibilité à l'ART a été définie comme un comptage de CD4+ VIH inconnu (31,8% contre 24,5%; P VIH dans le Free State (2009–2010) n'a pas été associée à une amélioration de la prise de l'ART. Les raisons n'en sont pas très claires. Par contre, il est préoccupant de constater la proportion élevée de statut VIH inconnu et d'absence de résultats de comptage des CD4+, surtout dans les structures intégrées, et la faible proportion de patients sous ART, qui témoigne d'une mise en œuvre médiocre de l'intégration.

  19. Integrating the New Generation of Isolde Controls into a Multi-Platform Environment

    CERN Document Server

    Deloose, I

    1996-01-01

    The CERN ISOLDE isotope separator facility has been relocated on the PS Booster machine and commissioned in spring 1992. Since then, the Isolde equipment is controlled by Front End Computers running DOS and desktop PCs, also named consoles, running Windows 3.1 as graphical user interface. Because of the success of the powerful development tools used at Isolde on the Windows platform (Visual Basic, Excel...), the desktop architecture has been extended to access the UNIX based PS control system through an access controlled ³gateway² computer. Linked to the introduction of Windows 95 at CERN, the Console - Equipment (FEC) computer communication model has been redesigned with enhanced performances and new features. The gradual replacement of IPX/SPX by TCP/IP as client-server communication protocol created new perspectives, like equipment access from the World Wide Web or through a wireless telephone connection. This report will explain the evolution from the initial ISOLDE control system up to its integration ...

  20. Integrating intimate partner violence content across curricula: Developing a new generation of nurse educators.

    Science.gov (United States)

    Tufts, Kimberly Adams; Clements, Paul T; Karlowicz, Karen A

    2009-01-01

    Abuse between intimate partners can take many forms. Prevalence data analyses confirm that intimate partner violence (IPV) is a widespread problem. Meeting the objectives of World Health Organization's "Global Campaign on Violence Prevention" will involve many organizations and institutions within and beyond the health care community. Educating prospective Nurse Educators about IPV does, however, present challenges, as most nurses lack awareness of IPV as a public health problem, have limited knowledge and erroneous beliefs about IPV, and are inexperienced in caring for survivors of IPV. Thus providing formal education and training in a supportive environment will enhance Nurse Educators' knowledge and skills about IPV while helping them to examine the benefits and limitations of various pedagogical approaches for teaching this critical content to students. Hence targeting educational efforts at nurses who are pursuing the academic role is an important first step toward raising the collective consciousness of nurses to the point that IPV education becomes an integral component of the nursing curriculum, and competence in caring for IPV survivors becomes the standard rather than the exception.

  1. A Framework for Understanding and Generating Integrated Solutions for Residential Peak Energy Demand

    Science.gov (United States)

    Buys, Laurie; Vine, Desley; Ledwich, Gerard; Bell, John; Mengersen, Kerrie; Morris, Peter; Lewis, Jim

    2015-01-01

    Supplying peak energy demand in a cost effective, reliable manner is a critical focus for utilities internationally. Successfully addressing peak energy concerns requires understanding of all the factors that affect electricity demand especially at peak times. This paper is based on past attempts of proposing models designed to aid our understanding of the influences on residential peak energy demand in a systematic and comprehensive way. Our model has been developed through a group model building process as a systems framework of the problem situation to model the complexity within and between systems and indicate how changes in one element might flow on to others. It is comprised of themes (social, technical and change management options) networked together in a way that captures their influence and association with each other and also their influence, association and impact on appliance usage and residential peak energy demand. The real value of the model is in creating awareness, understanding and insight into the complexity of residential peak energy demand and in working with this complexity to identify and integrate the social, technical and change management option themes and their impact on appliance usage and residential energy demand at peak times. PMID:25807384

  2. Study report recommendations for the next generation Range Safety System (RSS) Integrated Receiver/Decoder (IRD)

    Science.gov (United States)

    Crosby, Robert H.

    1992-01-01

    The Integrated Receiver/Decoder (IRD) currently used on the Space Shuttle was designed in the 1980 and prior time frame. Over the past 12 years, several parts have become obsolete or difficult to obtain. As directed by the Marshall Space Flight Center, a primary objective is to investigate updating the IRD design using the latest technology subsystems. To take advantage of experience with the current designs, an analysis of failures and a review of discrepancy reports, material review board actions, scrap, etc. are given. A recommended new design designated as the Advanced Receiver/Decoder (ARD) is presented. This design uses the latest technology components to simplify circuits, improve performance, reduce size and cost, and improve reliability. A self-test command is recommended that can improve and simplify operational procedures. Here, the new design is contrasted with the old. Possible simplification of the total Range Safety System is discussed, as is a single-step crypto technique that can improve and simplify operational procedures.

  3. Glucoregulation in normal weight schizophrenia patients treated by first generation antipsychotics

    Directory of Open Access Journals (Sweden)

    Marić Nađa

    2008-01-01

    Full Text Available Introduction Schizophrenia patients are at greater risk of obesity, diabetes mellitus (DM, lipid abnormalities and cardiovascular disorders. The metabolic complications in patients are associated with several risk factors: family history of DM, lifestyle, smoking, dietary habits, physical inactivity, but also with antipsychotic medication. In literature, most publications have been focused on the effects of the second generation antipsychotics (SGA on glucose metabolism. However, less attention has been paid to abnormality in glucoregulation, patients with schizophrenia treated with the first generation antipsychotics (FGA. Objective The present study evaluated glucose metabolism in normal weight schizophrenia patients treated with FGA. METHOD The cross-sectional study included 18 patients (FGA treated and 20 healthy controls with neither group differences in sex distribution, age, nor in BMI. Inclusion criteria were normal BMI (20-25 kg/m2. The glucose levels, insulin levels and growth hormone levels during oral glucose tolerance test (OGTT were measured. Results Fasting glucose and insulin levels did not differ significantly between groups. Groups differed in OGTT glucose and insulin peak and area under curve (AUC, level of significance p<0.05 (patients vs. controls: glucose peak 8.3±0.4 vs.6.9±0.5 mmol/l, glucose AUC 758±28 vs. 640±36 mU/l/120 min; insulin peak in patients 92.7±15.6 mU/l; insulin AUC 6060±1016 mU/l/120 min, insulin peak in controls 47.9±6.5 mU/l; insulin AUC 2597±256 mU/l/120 min. Conclusion Patients with schizophrenia, although with normal body mass index, are at high risk of abnormal glucose regulation. Not only SGA increase the risk of impaired glucoregulation and metabolic syndrome, but this may also be due to FGA or schizophrenia per se. .

  4. pBaSysBioll : an integrative plasmid generating gfp transcriptional fusions for high-throughput analysis of gene expression in Bacillus subtilis

    NARCIS (Netherlands)

    Botella, Eric; Fogg, Mark; Jules, Matthieu; Piersma, Sjouke; Doherty, Geoff; Hansen, Annette; Denham, Emma. L.; Le Chat, Ludovic; Veiga, Patrick; Bailey, Kirra; Lewis, Peter J.; van Dijl, Jan Maarten; Aymerich, Stephane; Wilkinson, Anthony J.; Devine, Kevin M.

    Plasmid pBaSysBioll was constructed for high-throughput analysis of gene expression in Bacillus subtilis. It is an integrative plasmid with a ligation-independent cloning (LIC) site, allowing the generation of transcriptional gfpmut3 fusions with desired promoters. Integration is by a Campbell-type

  5. pBaSysBioll : an integrative plasmid generating gfp transcriptional fusions for high-throughput analysis of gene expression in Bacillus subtilis

    NARCIS (Netherlands)

    Botella, Eric; Fogg, Mark; Jules, Matthieu; Piersma, Sjouke; Doherty, Geoff; Hansen, Annette; Denham, Emma. L.; Le Chat, Ludovic; Veiga, Patrick; Bailey, Kirra; Lewis, Peter J.; van Dijl, Jan Maarten; Aymerich, Stephane; Wilkinson, Anthony J.; Devine, Kevin M.

    2010-01-01

    Plasmid pBaSysBioll was constructed for high-throughput analysis of gene expression in Bacillus subtilis. It is an integrative plasmid with a ligation-independent cloning (LIC) site, allowing the generation of transcriptional gfpmut3 fusions with desired promoters. Integration is by a Campbell-type

  6. Realizing Relevance: The Influence of Domain-Specific Information on Generation of New Knowledge through Integration in 4- to 8-Year-Old Children

    Science.gov (United States)

    Bauer, Patricia J.; Larkina, Marina

    2017-01-01

    In accumulating knowledge, direct modes of learning are complemented by productive processes, including self-generation based on integration of separate episodes. Effects of the number of potentially relevant episodes on integration were examined in 4- to 8-year-olds (N = 121; racially/ethnically heterogeneous sample, English speakers, from large…

  7. Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy

    Directory of Open Access Journals (Sweden)

    Xiaojie Wang

    2012-01-01

    Full Text Available Islet cell transplantation offers a potential cure for type 1 diabetes, but it is challenged by insufficient donor tissue and side effects of current immunosuppressive drugs. Therefore, alternative sources of insulin-producing cells and isletfriendly immunosuppression are required to increase the efficiency and safety of this procedure. Beta cells can be transdifferentiated from precursors or another heterologous (non-beta-cell source. Recent advances in beta cell regeneration from somatic cells such as fibroblasts could circumvent the usage of immunosuppressive drugs. Therefore, generation of patient-specific beta cells provides the potential of an evolutionary treatment for patients with diabetes.

  8. Quick genetic screening using targeted next-generation sequencing in patients with tuberous sclerosis.

    Science.gov (United States)

    Liu, Qing; Huang, Yan; Zhang, Mingrong; Wang, Lian Qing; Guo, Xia Nan; Si, Nuo; Qi, Zhan; Zhou, Xiang Qin; Cui, Li-ying

    2015-04-01

    Tuberous sclerosis complex is an autosomal dominant disorder characterized by hamartomas in multiple organ systems. Mutations in the 2 large genes TSC1 and TSC2 have been demonstrated to be associated with tuberous sclerosis complex by various mutation screening methods. Targeted next-generation sequencing for genetic analysis is performed in the current study and is proved to be less cost, labor, and time consuming compared with Sanger sequencing. Two de novo and 1 recurrent TSC2 mutation in patients with tuberous sclerosis complex were revealed. Clinical details of patients were described and the underlying mechanism of the 2 novel TSC2 mutations, c.245G>A(p.W82X) and c.5405_5408dupACTT(p.P1803Lfs*25), were discussed. These results added to variability of TSC mutation spectrum and suggest that targeted next-generation sequencing could be the primary choice over Sanger sequencing in future tuberous sclerosis complex genetic counseling.

  9. A Workflow for Patient-Individualized Virtual Angiogram Generation Based on CFD Simulation

    Directory of Open Access Journals (Sweden)

    Jürgen Endres

    2012-01-01

    Full Text Available Increasing interest is drawn on hemodynamic parameters for classifying the risk of rupture as well as treatment planning of cerebral aneurysms. A proposed method to obtain quantities such as wall shear stress, pressure, and blood flow velocity is to numerically simulate the blood flow using computational fluid dynamics (CFD methods. For the validation of those calculated quantities, virtually generated angiograms, based on the CFD results, are increasingly used for a subsequent comparison with real, acquired angiograms. For the generation of virtual angiograms, several patient-specific parameters have to be incorporated to obtain virtual angiograms which match the acquired angiograms as best as possible. For this purpose, a workflow is presented and demonstrated involving multiple phantom and patient cases.

  10. Adherence predicts symptomatic and psychosocial remission in schizophrenia: Naturalistic study of patient integration in the community.

    Science.gov (United States)

    Bernardo, Miguel; Cañas, Fernando; Herrera, Berta; García Dorado, Marta

    Psychosocial functioning in patients with schizophrenia attended in daily practice is an understudied aspect. The aim of this study was to assess the relationship between symptomatic and psychosocial remission and adherence to treatment in schizophrenia. This cross-sectional, non-interventional, and multicenter study assessed symptomatic and psychosocial remission and community integration of 1,787 outpatients with schizophrenia attended in Spanish mental health services. Adherence to antipsychotic medication in the previous year was categorized as≥80% vs.<80%. Symptomatic remission was achieved in 28.5% of patients, and psychosocial remission in 26.1%. A total of 60.5% of patients were classified as adherent to antipsychotic treatment and 41% as adherent to non-pharmacological treatment. During the index visit, treatment was changed in 28.4% of patients, in 31.1% of them because of low adherence (8.8% of the total population). Adherent patients showed higher percentages of symptomatic and psychosocial remission than non-adherent patients (30.5 vs. 25.4%, P<.05; and 32 vs. 17%, P<.001, respectively). Only 3.5% of the patients showed an adequate level of community integration, which was also higher among adherent patients (73.0 vs. 60.1%, P<.05). Adherence to antipsychotic medication was associated with symptomatic and psychosocial remission as well as with community integration. Copyright © 2016 SEP y SEPB. Publicado por Elsevier España, S.L.U. All rights reserved.

  11. Differential in vitro inhibition of thrombin generation by anticoagulant drugs in plasma from patients with cirrhosis.

    Directory of Open Access Journals (Sweden)

    Wilma Potze

    Full Text Available BACKGROUND: Treatment and prevention of thrombotic complications is frequently required in patients with cirrhosis. However anticoagulant therapy is often withheld from these patients, because of the perceived bleeding diathesis. As a result of the limited clinical experience, the anticoagulant of choice for the various indications is still not known. OBJECTIVES: We evaluated the in vitro effect of clinically approved anticoagulant drugs in plasma from patients with cirrhosis. PATIENTS/METHODS: Thirty patients with cirrhosis and thirty healthy controls were studied. Thrombin generation assays were performed before and after addition of unfractionated heparin, low molecular weight heparin, fondaparinux, dabigatran, and rivaroxaban, to estimate anticoagulant potencies of these drugs. RESULTS: Addition of dabigatran led to a much more pronounced reduction in endogenous thrombin potential in patients compared to controls (72.6% reduction in patients vs. 12.8% reduction in controls, P<0.0001. The enhanced effect of dabigatran was proportional to the severity of disease. In contrast, only a slightly increased anticoagulant response to heparin and low molecular weight heparin and even a reduced response to fondaparinux and rivaroxaban was observed in plasma from cirrhotic patients as compared to control plasma. CONCLUSIONS: The anticoagulant potency of clinically approved drugs differs substantially between patients with cirrhosis and healthy individuals. Whereas dabigatran and, to a lesser extent, heparin and low molecular weight heparin are more potent in plasma from patients with cirrhosis, fondaparinux and rivaroxaban showed a decreased anticoagulant effect. These results may imply that in addition to dose adjustments based on altered pharmacokinetics, drug-specific dose adjustments based on altered anticoagulant potency may be required in patients with cirrhosis.

  12. LPV control for the full region operation of a wind turbine integrated with synchronous generator.

    Science.gov (United States)

    Cao, Guoyan; Grigoriadis, Karolos M; Nyanteh, Yaw D

    2015-01-01

    Wind turbine conversion systems require feedback control to achieve reliable wind turbine operation and stable current supply. A robust linear parameter varying (LPV) controller is proposed to reduce the structural loads and improve the power extraction of a horizontal axis wind turbine operating in both the partial load and the full load regions. The LPV model is derived from the wind turbine state space models extracted by FAST (fatigue, aerodynamics, structural, and turbulence) code linearization at different operating points. In order to assure a smooth transition between the two regions, appropriate frequency-dependent varying scaling parametric weighting functions are designed in the LPV control structure. The solution of a set of linear matrix inequalities (LMIs) leads to the LPV controller. A synchronous generator model is connected with the closed LPV control loop for examining the electrical subsystem performance obtained by an inner speed control loop. Simulation results of a 1.5 MW horizontal axis wind turbine model on the FAST platform illustrates the benefit of the LPV control and demonstrates the advantages of this proposed LPV controller, when compared with a traditional gain scheduling PI control and prior LPV control configurations. Enhanced structural load mitigation, improved power extraction, and good current performance were obtained from the proposed LPV control.

  13. Integrating hydrograph modeling with real-time flow monitoring to generate hydrograph-specific sampling schemes

    Science.gov (United States)

    Gall, Heather E.; Jafvert, Chad T.; Jenkinson, Byron

    2010-11-01

    Automated sample collection for water quality research and evaluation generally is performed by simple time-paced or flow-weighted sampling protocols. However, samples collected on strict time-paced or flow-weighted schemes may not adequately capture all elements of storm event hydrographs (i.e., rise, peak, and recession). This can result in inadequate information for calculating chemical mass flux over storm events. In this research, an algorithm was developed to guide automated sampling of hydrographs based on storm-specific information. A key element of the new "hydrograph-specific sampling scheme" is the use of a hydrograph recession model for predicting the hydrograph recession curve, during which flow-paced intervals are calculated for scheduling the remaining samples. The algorithm was tested at a tile drained Midwest agricultural site where real-time flow data were processed by a programmable datalogger that in turn activated an automated sampler at the appropriate sampling times to collect a total of twenty samples during each storm event independent of the number of sequential hydrographs generated. The utility of the algorithm was successfully tested with hydrograph data collected at both a tile drain and agricultural ditch, suggesting the potential for general applicability of the method. This sampling methodology is flexible in that the logic can be adapted for use with any hydrograph recession model; however, in this case a power law equation proved to be the most practical model.

  14. LPV Control for the Full Region Operation of a Wind Turbine Integrated with Synchronous Generator

    Directory of Open Access Journals (Sweden)

    Guoyan Cao

    2015-01-01

    Full Text Available Wind turbine conversion systems require feedback control to achieve reliable wind turbine operation and stable current supply. A robust linear parameter varying (LPV controller is proposed to reduce the structural loads and improve the power extraction of a horizontal axis wind turbine operating in both the partial load and the full load regions. The LPV model is derived from the wind turbine state space models extracted by FAST (fatigue, aerodynamics, structural, and turbulence code linearization at different operating points. In order to assure a smooth transition between the two regions, appropriate frequency-dependent varying scaling parametric weighting functions are designed in the LPV control structure. The solution of a set of linear matrix inequalities (LMIs leads to the LPV controller. A synchronous generator model is connected with the closed LPV control loop for examining the electrical subsystem performance obtained by an inner speed control loop. Simulation results of a 1.5 MW horizontal axis wind turbine model on the FAST platform illustrates the benefit of the LPV control and demonstrates the advantages of this proposed LPV controller, when compared with a traditional gain scheduling PI control and prior LPV control configurations. Enhanced structural load mitigation, improved power extraction, and good current performance were obtained from the proposed LPV control.

  15. Biomass Power Generation through Direct Integration of Updraft Gasifier and Stirling Engine Combustion System

    Directory of Open Access Journals (Sweden)

    Jai-Houng Leu

    2010-01-01

    Full Text Available Biomass is the largest renewable energy source in the world. Its importance grows gradually in the future energy market. Since most biomass sources are low in energy density and are widespread in space, small-scale biomass conversion system is therefore more competitive than a large stand-alone conversion plant. The current study proposes a small-scale solid biomass power system to explore the viability of direct coupling of an updraft fixed bed gasifier with a Stirling engine. The modified updraft fixed bed gasifier employs an embedded combustor inside the gasifier to fully combust the synthetic gas generated by the gasifier. The flue gas produced by the synthetic gas combustion inside the combustion tube is piped directly to the heater head of the Stirling engine. The engine will then extract and convert the heat contained in the flue gas into electricity automatically. Output depends on heat input. And, the heat input is proportional to the flow rate and temperature of the flue gas. The preliminary study of the proposed direct coupling of an updraft gasifier with a 25 kW Stirling engine demonstrates that full power output could be produced by the current system. It could be found from the current investigation that no auxiliary fuel is required to operate the current system smoothly. The proposed technology and units could be considered as a viable solid biomass power system.

  16. Generating workplace accommodations: lessons learned from the integrated case management study.

    Science.gov (United States)

    Shaw, William S; Feuerstein, Michael

    2004-09-01

    Modified duty and other accommodations by employers have been shown to be helpful in managing workplace disability associated with injuries and illnesses. Benefits of accommodation have been attributed to both reduced physical and psychosocial exposures. Although many employers have adopted proactive return to work policies that emphasize temporary work modifications, standardized methods for specifying appropriate accommodations have been elusive. On the basis of the experiences and results of a randomized controlled study of case management services for work-related upper extremity disorders, we describe issues pertaining to the application of self-report measures of function and exposure assessment for generating accommodations. Challenges of this approach are 1) including specific work tasks on measures of physical function; 2) improving concordance between ergonomic exposure categories and methods of accommodation; and 3) providing a structured process for negotiating employee and employer preferences. To improve the effectiveness and efficiency of accommodation efforts, new tools for assessing function and ergonomic exposures in the workplace should be developed to specify accommodations more directly.

  17. Integrated development and testing of multi-kilowatt TPV generator systems

    Science.gov (United States)

    West, Edward M.; Connelly, William R.

    1999-03-01

    On going research at Western Washington University has brought about a number of important advances in the state of TPV system development. Specific areas of TPV work include new cylindrical PV cell array designs, improved burner systems, enhanced recuperator performance and overall TPV system development. System development includes the implementation of the TPV8 generator in the purpose built Viking 29 TPV series hybrid demonstration vehicle (1). TPV research capability enhancements include the development of a computerized test and data acquisition system, an array characterization system (2), and an array flash testing station for quality assurance prior to final assembly. TPV system achievements include steady-state cell output levels of 2.4 watts/cm2 on an array test station and 1.5 watts/cm2 using a combustion source. Successful development of enhanced recuperators with thermal efficiency above 80%. Array output levels of 1 kilowatt have been achieved with array efficiencies in excess of 7.5%. TPV technology development guidelines are discussed with the hope of focusing the community on these important issues.

  18. Integrity assurance of the secondary side of steam generator in Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Joung Soo; Kim, Hong Pyo; Lim, Yun Soo; Hwang, Seong Sik; Yi, Yong Sun; Kim, Dong Jin; Kim, Sung Soo; Jung, Man Gyo

    2005-09-15

    Residual stresses on the expansion transition regions of steam generator tubes expanded by explosive and hydraulic expansion techniques were measured using several different methods such as strain gauge, XRD, electrolytic polishing, and stress corrosion cracking methods. The SCC method was applied by measuring the cracking time using C-ring specimens to which precisely measured stress had been imposed and comparing the cracking time of the expanded tube specimens in order to estimate the magnitude of residual stress developed on the expansion transition regions. Axial residual stress on the outer surface of both, Inconel 600 and 690 tubes was measured to be mainly compressive, which can not induce circumferential ODSCC on the expansion transition regions. According to SCC test results, SCC was not observed to occur on the expansion transition regions of the expanded model specimen tubes, which means that the residual stresses developed on the expansion transition regions by the explosive and the hydraulic expansion methods are not big enough to induce SCC. However, sludge piled up on the top of tubesheet during operation of NPPs might change the stress state on the expansion transition regions, which can result in occurring SCC.

  19. Real time hardware implementation of power converters for grid integration of distributed generation and STATCOM systems

    Science.gov (United States)

    Jaithwa, Ishan

    Deployment of smart grid technologies is accelerating. Smart grid enables bidirectional flows of energy and energy-related communications. The future electricity grid will look very different from today's power system. Large variable renewable energy sources will provide a greater portion of electricity, small DERs and energy storage systems will become more common, and utilities will operate many different kinds of energy efficiency. All of these changes will add complexity to the grid and require operators to be able to respond to fast dynamic changes to maintain system stability and security. This thesis investigates advanced control technology for grid integration of renewable energy sources and STATCOM systems by verifying them on real time hardware experiments using two different systems: d SPACE and OPAL RT. Three controls: conventional, direct vector control and the intelligent Neural network control were first simulated using Matlab to check the stability and safety of the system and were then implemented on real time hardware using the d SPACE and OPAL RT systems. The thesis then shows how dynamic-programming (DP) methods employed to train the neural networks are better than any other controllers where, an optimal control strategy is developed to ensure effective power delivery and to improve system stability. Through real time hardware implementation it is proved that the neural vector control approach produces the fastest response time, low overshoot, and, the best performance compared to the conventional standard vector control method and DCC vector control technique. Finally the entrepreneurial approach taken to drive the technologies from the lab to market via ORANGE ELECTRIC is discussed in brief.

  20. Integration of Multi-Modal Biomedical Data to Predict Cancer Grade and Patient Survival.

    Science.gov (United States)

    Phan, John H; Hoffman, Ryan; Kothari, Sonal; Wu, Po-Yen; Wang, May D

    2016-02-01

    The Big Data era in Biomedical research has resulted in large-cohort data repositories such as The Cancer Genome Atlas (TCGA). These repositories routinely contain hundreds of matched patient samples for genomic, proteomic, imaging, and clinical data modalities, enabling holistic and multi-modal integrative analysis of human disease. Using TCGA renal and ovarian cancer data, we conducted a novel investigation of multi-modal data integration by combining histopathological image and RNA-seq data. We compared the performances of two integrative prediction methods: majority vote and stacked generalization. Results indicate that integration of multiple data modalities improves prediction of cancer grade and outcome. Specifically, stacked generalization, a method that integrates multiple data modalities to produce a single prediction result, outperforms both single-data-modality prediction and majority vote. Moreover, stacked generalization reveals the contribution of each data modality (and specific features within each data modality) to the final prediction result and may provide biological insights to explain prediction performance.

  1. Clinical Document Architecture integration system to support patient referral and reply letters.

    Science.gov (United States)

    Lee, Sung-Hyun; Song, Joon Hyun; Kim, Il Kon; Kim, Jeong-Whun

    2016-06-01

    Many Clinical Document Architecture (CDA) referrals and reply documents have been accumulated for patients since the deployment of the Health Information Exchange System (HIES) in Korea. Clinical data were scattered in many CDA documents and this took too much time for physicians to read. Physicians in Korea spend only limited time per patient as insurances in Korea follow a fee-for-service model. Therefore, physicians were not allowed sufficient time for making medical decisions, and follow-up care service was hindered. To address this, we developed CDA Integration Template (CIT) and CDA Integration System (CIS) for the HIES. The clinical items included in CIT were defined reflecting the Korean Standard for CDA Referral and Reply Letters and requests by physicians. CIS integrates CDA documents of a specified patient into a single CDA document following the format of CIT. Finally, physicians were surveyed after CIT/CIS adoption, and they indicated overall satisfaction.

  2. On-Line Monitoring and Diagnostics of the Integrity of Nuclear Plant Steam Generators and Heat Exchangers, Volumes 1, 2

    Energy Technology Data Exchange (ETDEWEB)

    Upadhyaya, Belle R. [Univ. of Tennessee, Knoxville, TN (United States); Hines, J. Wesley [Univ. of Tennessee, Knoxville, TN (United States); Lu, Baofu [Univ. of Tennessee, Knoxville, TN (United States)

    2005-06-03

    The overall purpose of this Nuclear Engineering Education Research (NEER) project was to integrate new, innovative, and existing technologies to develop a fault diagnostics and characterization system for nuclear plant steam generators (SG) and heat exchangers (HX). Issues related to system level degradation of SG and HX tubing, including tube fouling, performance under reduced heat transfer area, and the damage caused by stress corrosion cracking, are the important factors that influence overall plant operation, maintenance, and economic viability of nuclear power systems. The research at The University of Tennessee focused on the development of techniques for monitoring process and structural integrity of steam generators and heat exchangers. The objectives of the project were accomplished by the completion of the following tasks. All the objectives were accomplished during the project period. This report summarizes the research and development activities, results, and accomplishments during June 2001 September 2004. Development and testing of a high-fidelity nodal model of a U-tube steam generator (UTSG) to simulate the effects of fouling and to generate a database representing normal and degraded process conditions. Application of the group method of data handling (GMDH) method for process variable prediction. Development of a laboratory test module to simulate particulate fouling of HX tubes and its effect on overall thermal resistance. Application of the GMDH technique to predict HX fluid temperatures, and to compare with the calculated thermal resistance.Development of a hybrid modeling technique for process diagnosis and its evaluation using laboratory heat exchanger test data. Development and testing of a sensor suite using piezo-electric devices for monitoring structural integrity of both flat plates (beams) and tubing. Experiments were performed in air, and in water with and without bubbly flow. Development of advanced signal processing methods using

  3. 函数粗集生成的粗积分%Rough Integrals Generated by Function Rough Sets

    Institute of Scientific and Technical Information of China (English)

    于秀清; 徐凤生

    2011-01-01

    The concepts of the lower approximation integral, the upper approximation integral and rough integrals are given on the basis of function rough sets. Based on these concepts, the relation of the lower approximation integrals, the relation of the upper approximation integrals, the relation of rough integrals, and the double median theorem of rough integrals are discussed. Rough integrals have finite contraction characteristic and finite extension characteristic.

  4. Mental health provider perspectives regarding integrated medical care for patients with serious mental illness.

    Science.gov (United States)

    Kilbourne, Amy M; Greenwald, Devra E; Bauer, Mark S; Charns, Martin P; Yano, Elizabeth M

    2012-11-01

    Integrated care for medical conditions is essential for persons with serious mental illness (SMI). This qualitative study describes mental health provider perspectives regarding barriers and facilitators of integrated care for patients with SMI. We interviewed providers from a national sample of Veterans Health Administration facilities that scored in the top or bottom percentile in medical care quality. Providers from high-performing sites reported substantial in-person contacts with general medical providers, while providers from low-performing sites reported stigma and limited communication with medical providers as major concerns. Interventions to improve mental health and medical provider communication may facilitate integrated care for persons with SMI.

  5. Aortic stiffness is associated with white matter integrity in patients with type 1 diabetes

    Energy Technology Data Exchange (ETDEWEB)

    Tjeerdema, Nathanja; Schinkel, Linda D. van [Leiden University Medical Center, Department of Endocrinology and General Internal Medicine (C7-Q), Albinusdreef 2, PO Box 9600, Leiden (Netherlands); Westenberg, Jos J.; Elderen, Saskia G. van; Buchem, Mark A. van; Grond, Jeroen van der; Roos, Albert de [Leiden University Medical Center, Department of Radiology, Leiden (Netherlands); Smit, Johannes W. [Leiden University Medical Center, Department of Endocrinology and General Internal Medicine (C7-Q), Albinusdreef 2, PO Box 9600, Leiden (Netherlands); University Medical Center Nijmegen, Department of General Internal Medicine, Nijmegen (Netherlands)

    2014-09-15

    To assess the association between aortic pulse wave velocity (PWV) as a marker of arterial stiffness and diffusion tensor imaging of brain white matter integrity in patients with type 1 diabetes using advanced magnetic resonance imaging (MRI) technology. Forty-one patients with type 1 diabetes (23 men, mean age 44 ± 12 years, mean diabetes duration 24 ± 13 years) were included. Aortic PWV was assessed using through-plane velocity-encoded MRI. Brain diffusion tensor imaging (DTI) measurements were performed on 3-T MRI. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were calculated for white and grey matter integrity. Pearson correlation and multivariable linear regression analyses including cardiovascular risk factors as covariates were assessed. Multivariable linear regression analyses revealed that aortic PWV is independently associated with white matter integrity FA (β = -0.777, p = 0.008) in patients with type 1 diabetes. This effect was independent of age, gender, mean arterial pressure, body mass index, smoking, duration of diabetes and glycated haemoglobin levels. Aortic PWV was not significantly related to grey matter integrity. Our data suggest that aortic stiffness is independently associated with reduced white matter integrity in patients with type 1 diabetes. (orig.)

  6. Medical Image Processing for Fully Integrated Subject Specific Whole Brain Mesh Generation

    Directory of Open Access Journals (Sweden)

    Chih-Yang Hsu

    2015-05-01

    Full Text Available Currently, anatomically consistent segmentation of vascular trees acquired with magnetic resonance imaging requires the use of multiple image processing steps, which, in turn, depend on manual intervention. In effect, segmentation of vascular trees from medical images is time consuming and error prone due to the tortuous geometry and weak signal in small blood vessels. To overcome errors and accelerate the image processing time, we introduce an automatic image processing pipeline for constructing subject specific computational meshes for entire cerebral vasculature, including segmentation of ancillary structures; the grey and white matter, cerebrospinal fluid space, skull, and scalp. To demonstrate the validity of the new pipeline, we segmented the entire intracranial compartment with special attention of the angioarchitecture from magnetic resonance imaging acquired for two healthy volunteers. The raw images were processed through our pipeline for automatic segmentation and mesh generation. Due to partial volume effect and finite resolution, the computational meshes intersect with each other at respective interfaces. To eliminate anatomically inconsistent overlap, we utilized morphological operations to separate the structures with a physiologically sound gap spaces. The resulting meshes exhibit anatomically correct spatial extent and relative positions without intersections. For validation, we computed critical biometrics of the angioarchitecture, the cortical surfaces, ventricular system, and cerebrospinal fluid (CSF spaces and compared against literature values. Volumina and surface areas of the computational mesh were found to be in physiological ranges. In conclusion, we present an automatic image processing pipeline to automate the segmentation of the main intracranial compartments including a subject-specific vascular trees. These computational meshes can be used in 3D immersive visualization for diagnosis, surgery planning with haptics

  7. Computerized axiography in TMD patients before and after therapy with 'function generating bites'.

    Science.gov (United States)

    Piancino, M G; Roberi, L; Frongia, G; Reverdito, M; Slavicek, R; Bracco, P

    2008-02-01

    The study evaluates the temporomandibular joint (TMJ) movements of patients with signs and symptoms of temporomandibular disorders (TMD) before and after therapy with the functional appliances of the 'function generating bite' (FGB) type. Thirty subjects suffering from TMD were selected and divided into two groups: group A (young patients: four males, nine females, mean age +/- standard deviation: 13.3+/-1.5 years); group B (adults: three males, 14 females, mean age +/- standard deviation: 23.2+/-4.4 years). A control group comprised 13 healthy subjects with perfect normal occlusion, TMD-free, was matched for age and sex with patient groups and was examined at T0 and after 12 months (T1). Computerized axiography was performed before and after therapy (average 13 months) with FGBs to evaluate any difference in condyle border movements. Results showed a statistically significant improvement after treatment, for groups A and B, in length, clicks, tracings with normal morphology, superimposition, deviations, regularity and return to starting position and speed (statistical analysis: chi-squared test) except for the symmetry of tracings which was significantly improved only for the young patient group. No statistically significant differences at time T0/T1 were found in the control group. In conclusion, the study shows that the TMJ tracings of TMD patients before and after therapy with 'FGB' significantly improve especially in young patients. FGB may be a useful appliance to improve TMJ function in young and adult TMD patients requiring orthodontic treatment.

  8. Integrative psychotherapeutic nursing home program to reduce multiple psychiatric symptoms of cognitively impaired patients and caregiver burden: randomized controlled trial

    NARCIS (Netherlands)

    Bakker, T.J.; Duivenvoorden, H.J.; Lee, J. van der; Olde Rikkert, M.G.M.; Beekman, A.T.; Ribbe, M.W.

    2011-01-01

    OBJECTIVE: To test the effectiveness of an integrative psychotherapeutic nursing home program (integrative reactivation and rehabilitation [IRR]) to reduce multiple neuropsychiatry symptoms (MNPS) of cognitively impaired patients and caregiver burden (CB). DESIGN: Randomized controlled trial. SETTIN

  9. Integrative Medical Care Plus Mindfulness Training for Patients With Congestive Heart Failure: Proof of Concept.

    Science.gov (United States)

    Kemper, Kathi J; Carmin, Cheryl; Mehta, Bella; Binkley, Phillip

    2016-10-01

    Congestive heart failure (CHF) has a high rate of morbidity and mortality. It is often accompanied by other medical and psychosocial comorbidities that complicate treatment and adherence. We conducted a proof of concept pilot project to determine the feasibility of providing integrative group medical visits plus mindfulness training for patients recently discharged with CHF. Patients were eligible if they had been discharged from an inpatient stay for CHF within the 12 months prior to the new program. The Compassionate Approach to Lifestyle and Mind-Body (CALM) Skills for Patients with CHF consisted of 8 weekly visits focusing on patient education about medications, diet, exercise, sleep, and stress management; group support; and training in mind-body skills such as mindfulness, self-compassion, and loving-kindness. Over two 8-week sessions, 8/11 (73%) patients completed at least 4 visits. The patients had an average age of 57 years. The most common comorbidities were weight gain, sleep problems, and fatigue. After the sessions, 100% of patients planned to make changes to their diet, exercise, and stress management practices. Over half of the patients who met with a pharmacist had a medication-related problem. Improvements were observed in depression, fatigue, and satisfaction with life. Integrative group visits focusing on healthy lifestyle, support, and skill-building are feasible even among CHF patients and should be evaluated in controlled trials as a patient-centered approach to improving outcomes related to improving medication management, depression, fatigue, and quality of life.

  10. Does the Integration of Personalized Ultrasound Change Patient Management in Critical Care Medicine? Observational Trials

    Directory of Open Access Journals (Sweden)

    Raoul Breitkreutz

    2013-01-01

    Full Text Available Objective. To test the influence of personalized ultrasound (PersUS on patient management in critical care. Design of the Study. Prospective, observational, and critical care setting. Four substudies compared PersUS and mobile ultrasound, work distribution, and diagnostic and procedural quality. Patients and Interventions. 640 patient ultrasound exams including 548 focused diagnostic exams and 92 interventional procedures. Main Outcome Measures. Number of studies, physician’s judgement of feasibility, time of usage per patient, and referrals to echo lab. Results. Randomized availability of PersUS increased its application in ICU work shifts more than twofold from 33 to 68 exams mainly for detection and therapy of effusions. Diagnostic and procedural quality was rated as excellent/very good in PersUS-guided puncture in 95% of cases. Integrating PersUS within an initial physical examination of 48 randomized cases in an emergency department, PersUS extended the examination time by 100 seconds. Interestingly, PersUS integration into 53 randomized regular ward rounds of 1007 patients significantly reduced average contact time per patient by 103 seconds from 8.9 to 7.2 minutes. Moreover, it lowered the patient referral rate to an echo lab from 20% to 2% within the study population. Conclusions. We propose the development of novel ultrasound-based clinical pathways by integration of PersUS.

  11. Does the integration of personalized ultrasound change patient management in critical care medicine? Observational trials.

    Science.gov (United States)

    Breitkreutz, Raoul; Campo Delľ Orto, Marco; Hamm, Christian; Cuca, Colleen; Zechner, Peter M; Stenger, Tanja; Walcher, Felix; Seeger, Florian H

    2013-01-01

    Objective. To test the influence of personalized ultrasound (PersUS) on patient management in critical care. Design of the Study. Prospective, observational, and critical care setting. Four substudies compared PersUS and mobile ultrasound, work distribution, and diagnostic and procedural quality. Patients and Interventions. 640 patient ultrasound exams including 548 focused diagnostic exams and 92 interventional procedures. Main Outcome Measures. Number of studies, physician's judgement of feasibility, time of usage per patient, and referrals to echo lab. Results. Randomized availability of PersUS increased its application in ICU work shifts more than twofold from 33 to 68 exams mainly for detection and therapy of effusions. Diagnostic and procedural quality was rated as excellent/very good in PersUS-guided puncture in 95% of cases. Integrating PersUS within an initial physical examination of 48 randomized cases in an emergency department, PersUS extended the examination time by 100 seconds. Interestingly, PersUS integration into 53 randomized regular ward rounds of 1007 patients significantly reduced average contact time per patient by 103 seconds from 8.9 to 7.2 minutes. Moreover, it lowered the patient referral rate to an echo lab from 20% to 2% within the study population. Conclusions. We propose the development of novel ultrasound-based clinical pathways by integration of PersUS.

  12. Time to accelerate integration of human factors and ergonomics in patient safety.

    Science.gov (United States)

    Gurses, Ayse P; Ozok, A Ant; Pronovost, Peter J

    2012-04-01

    Progress toward improving patient safety has been slow despite engagement of the health care community in improvement efforts. A potential reason for this sluggish pace is the inadequate integration of human factors and ergonomics principles and methods in these efforts. Patient safety problems are complex and rarely caused by one factor or component of a work system. Thus, health care would benefit from human factors and ergonomics evaluations to systematically identify the problems, prioritize the right ones, and develop effective and practical solutions. This paper gives an overview of the discipline of human factors and ergonomics and describes its role in improving patient safety. We provide examples of how human factors and ergonomics principles and methods have improved both care processes and patient outcomes. We provide five major recommendations to better integrate human factors and ergonomics in patient safety improvement efforts: build capacity among health care workers to understand human factors and ergonomics, create market forces that demand the integration of human factors and ergonomics design principles into medical technologies, increase the number of human factors and ergonomic practitioners in health care organizations, expand investments in improvement efforts informed by human factors and ergonomics, and support interdisciplinary research to improve patient safety. In conclusion, human factors and ergonomics must play a more prominent role in health care if we want to increase the pace in improving patient safety.

  13. DEVELOPMENT OF AN ADVANCED APPROACH FOR NEXT-GENERATION INTEGRATED RESERVOIR CHARACTERIZATION

    Energy Technology Data Exchange (ETDEWEB)

    Scott R. Reeves

    2005-04-01

    -to-log, log-to-crosswell seismic, and crosswell-to-surface seismic. One of the key attributes of the approach, which should result in the creation of high resolution reservoir characterization with greater accuracy and with less uncertainty than today's methods, is the inclusion of borehole seismic (such as crosswell and/or vertical seismic profiling--VSP) in the data collection scheme. Borehole seismic fills a critical gap in the resolution spectrum of reservoir measurements between the well log and surface seismic scales, thus establishing important constraints on characterization outcomes. The results of that initial study showed that it is, in fact, feasible to establish the three critical relationships required, and that use of data at different scales of measurement to create high-resolution reservoir characterization is possible. Based on the results of this feasibility study, in September 2001, the DOE, again through ARI, launched a subsequent two-year government-industry R&D project to further develop and demonstrate the technology. The goals of this project were to: (1) Make improvements to the initial methodology by incorporating additional VI technologies (such as clustering), using core measurements in place of magnetic resonance image (MRI) logs, and streamlining the workflow, among others. (2) Demonstrate the approach in an integrated manner at a single field site, and validate it via reservoir modeling or other statistical methods.

  14. Random number generation deficits in patients with multiple sclerosis: Characteristics and neural correlates.

    Science.gov (United States)

    Geisseler, Olivia; Pflugshaupt, Tobias; Buchmann, Andreas; Bezzola, Ladina; Reuter, Katja; Schuknecht, Bernhard; Weller, David; Linnebank, Michael; Brugger, Peter

    2016-09-01

    Human subjects typically deviate systematically from randomness when attempting to produce a sequence of random numbers. Despite an increasing number of behavioral and functional neuroimaging studies on random number generation (RNG), its structural correlates have never been investigated. We set out to fill this gap in 44 patients with multiple sclerosis (MS), a disease whose impact on RNG has never been studied. The RNG task required the paced (1 Hz) generation of the numbers from 1 to 6 in a sequence as random as possible. The same task was administered in 39 matched healthy controls. To assess neuroanatomical correlates such as cortical thickness, lesion load and third ventricle width, all subjects underwent high-resolution structural MRI. Compared to controls, MS patients exhibited an enhanced tendency to arrange consecutive numbers in an ascending order ("forward counting"). Furthermore, patients showed a higher susceptibility to rule breaks (producing out-of-category digits like 7) and to skip beats of the metronome. Clinico-anatomical correlation analyses revealed two main findings: First, increased counting in MS patients was associated with higher cortical lesion load. Second, increased number of skipped beats was related to widespread cortical thinning. In conclusion, our test results illustrate a loss of behavioral complexity in the course of MS, while the imaging results suggest an association between this loss and cortical pathology.

  15. Integrated Power/Attitude Control System (IPACS) study. Volume 1: Feasibility studies. [application of flywheels for power storage and generation

    Science.gov (United States)

    Notti, J. E.; Cormack, A., III; Schmill, W. C.

    1974-01-01

    An Integrated Power/Attitude Control System (IPACS) concept consisting of an array of spinning flywheels, with or without gimbals, capable of performing the dual function of power storage and generation, as well as attitude control has been investigated. This system provides attitude control through momentum storage, and replaces the storage batteries onboard the spacecraft. The results of the investigation are presented in two volumes. The trade-off studies performed to establish the feasibility, cost effectiveness, required level of development, and boundaries of application of IPACS to a wide variety of spacecraft are discussed. The conceptual designs for a free-flying research application module (RAM), and for a tracking and data relay satellite (TDRS) are presented. Results from dynamic analyses and simulations of the IPACS conceptual designs are included.

  16. Integrated generation of solid fuel and biogas from green cut material from landscape conservation and private households.

    Science.gov (United States)

    Hensgen, F; Richter, F; Wachendorf, M

    2011-11-01

    Green cut material is a potential source of renewable energy which is not fully exploited through conventional energy recovery systems. A new energy conversion process, the integrated generation of solid fuel and biogas from biomass (IFBB), which includes mechanical separation after hydro-thermal conditioning, was investigated. Ash softening temperature and lower heating value of the solid fuel were increased through the IFFB process in comparison to the untreated raw material. The net energy yield of IFBB at 40 °C conditioning temperature ranged between 1.96 and 2.85 kWh kg(-1) dry matter (DM) and for the direct combustion between 1.75 and 2.65 kWh kg(-1) DM. Conversion efficiencies for the IFBB system were 0.42-0.68 and for direct combustion 0.42-0.63. The IFBB system produces storable energy from material which is nowadays not used for energy conversion.

  17. A generative model for OCT retinal layer segmentation by integrating graph-based multi-surface searching and image registration.

    Science.gov (United States)

    Zheng, Yuanjie; Xiao, Rui; Wang, Yan; Gee, James C

    2013-01-01

    We proposed a generative probabilistic modeling framework for automated segmentation of retinal layers from Optical Coherence Tomography (OCT) data. The objective is to learn a segmentation protocol from a collection of training images that have been manually labeled. Our model results in a novel OCT retinal layer segmentation approach which integrates algorithms of simultaneous searching of multiple interacting layer interfaces, image registration and machine learning. Different from previous work, our approach combines the benefits of constraining spatial layout of retinal layers, using a set of more robust local image descriptors, employing a mechanism for learning from manual labels and incorporating the inter-subject anatomical similarities of retina. With a set of OCT volumetric images from mutant canine retinas, we experimentally validated that our approach outperforms two state-of-the-art techniques.

  18. Mi-STAR: Designing Integrated Science Curriculum to Address the Next Generation Science Standards and Their Foundations

    Science.gov (United States)

    Gochis, E. E.; Huntoon, J. E.

    2015-12-01

    Mi-STAR (Michigan Science Teaching and Assessment Reform, http://mi-star.mtu.edu/) was funded by the Herbert H. and Grace A. Dow Foundation to reform K-12 science education to present science as an integrated body of knowledge that is applied to address societal issues. To achieve this goal, Mi-STAR is developing an integrated science curriculum for the middle grades that will be aligned with the Next Generation Science Standards (NGSS). Similar to the geosciences, the curriculum requires the integration of science, engineering and math content to explore 21st-century issues and demonstrates how these concepts can be used in service of society. The curriculum is based on the Mi-STAR Unit Specification Chart which pairs interdisciplinary themes with bundled NGSS Performance Expectations. Each unit is developed by a collaborative team of K-12 teachers, university STEM content experts and science education experts. Prior to developing a unit, each member on the team attends the on-line Mi-STAR Academy, completing 18+ hours of professional development (PD). This on-line PD program familiarizes teachers and experts with necessary pedagogical and content background knowledge, including NGSS and three-dimensional learning. With this background, teams use a staged, backwards design process to craft a multi-week unit based on a series of performance based tasks, or 'challenges' that engage students in actively doing science and engineering. Each unit includes Disciplinary Core Ideas from multiple disciplines, which focus on local and familiar examples that demonstrate the relevance of science in student's lives. Performance-based assessments are interwoven throughout the unit. Mi-STAR units will go through extensive pilot testing in several school districts across the state of Michigan. Additionally, the Mi-STAR program will develop teacher professional development programs to support implementation of the curriculum and design a pre-service teacher program in integrated

  19. Integrating evidence on patient preferences in healthcare policy decisions: protocol of the patient-VIP study

    NARCIS (Netherlands)

    Dirksen, C.D.; Utens, C.M.; Joore, M.A.; Barneveld, T.A. van; Boer, B.; Dreesens, D.H.; Laarhoven, H. van; Smit, C.; Stiggelbout, A.M.; Weijden, T.T. van der

    2013-01-01

    BACKGROUND: Despite a strong movement towards active patient involvement in healthcare policy decisions, systematic and explicit consideration of evidence of this research on patient preferences seems limited. Furthermore, little is known about the opinions of several stakeholders towards considerat

  20. Integrative oncology for breast cancer patients: introduction of an expert-based model

    Directory of Open Access Journals (Sweden)

    Dobos Gustav J

    2012-11-01

    Full Text Available Abstract Background Malignant breast neoplasms are among the most frequent forms of cancer in the Western world. Conventional treatment of breast cancer may include surgery, hormonal therapy, chemotherapy, radiation and/or immunotherapy, all of which are often accompanied by severe side effects. Complementary and alternative medicine (CAM treatments have been shown to be effective in alleviating those symptoms. Furthermore, with patient survival rates increasing, oncologists, psychologists and other therapists have to become more sensitive to the needs of cancer survivors that go beyond than the mere alleviation of symptoms. Many CAM methods are geared to treat the patient in a holistic manner and thus are also concerned with the patient’s psychological and spiritual needs. Discussion The use of certain CAM methods may become problematic when, as frequently occurs, patients use them indiscriminately and without informing their oncologists. Herbal medicines and dietary supplements, especially, may interfere with primary cancer treatments or have other detrimental effects. Thus, expertise in this highly specialized field of integrative medicine should be available to patients so that they can be advised about the benefits and negative effects of such preparations and practices. Being a beneficial combination of conventional and CAM care, integrative oncology makes possible the holistic approach to cancer care. The concept of integrative oncology for breast cancer is jointly practiced by the Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, academic teaching hospital of the University of Duisburg-Essen, and the Breast Center at Kliniken Essen-Mitte in Germany. This model is introduced here; its scope is reviewed, and its possible implications for the practice of integrative medicine are discussed. Summary Evidence-based integrative care is crucial to the field of oncology in establishing state-of-the-art care for breast