WorldWideScience

Sample records for integrating cell processing

  1. Polycation-mediated integrated cell death processes

    DEFF Research Database (Denmark)

    Parhamifar, Ladan; Andersen, Helene; Wu, Linping

    2014-01-01

    standard. PEIs are highly efficient transfectants, but depending on their architecture and size they induce cytotoxicity through different modes of cell death pathways. Here, we briefly review dynamic and integrated cell death processes and pathways, and discuss considerations in cell death assay design...

  2. Integrated hydrogen production process from cellulose by combining dark fermentation, microbial fuel cells, and a microbial electrolysis cell

    KAUST Repository

    Wang, Aijie; Sun, Dan; Cao, Guangli; Wang, Haoyu; Ren, Nanqi; Wu, Wei-Min; Logan, Bruce E.

    2011-01-01

    Hydrogen gas production from cellulose was investigated using an integrated hydrogen production process consisting of a dark fermentation reactor and microbial fuel cells (MFCs) as power sources for a microbial electrolysis cell (MEC). Two MFCs

  3. Integrated processes for expansion and differentiation of human pluripotent stem cells in suspended microcarriers cultures

    International Nuclear Information System (INIS)

    Lam, Alan Tin-Lun; Chen, Allen Kuan-Liang; Ting, Sherwin Qi-Peng; Reuveny, Shaul; Oh, Steve Kah-Weng

    2016-01-01

    Current methods for human pluripotent stem cells (hPSC) expansion and differentiation can be limited in scalability and costly (due to their labor intensive nature). This can limit their use in cell therapy, drug screening and toxicity assays. One of the approaches that can overcome these limitations is microcarrier (MC) based cultures in which cells are expanded as cell/MC aggregates and then directly differentiated as embryoid bodies (EBs) in the same agitated reactor. This integrated process can be scaled up and eliminate the need for some culture manipulation used in common monolayer and EBs cultures. This review describes the principles of such microcarriers based integrated hPSC expansion and differentiation process, and parameters that can affect its efficiency (such as MC type and extracellular matrix proteins coatings, cell/MC aggregates size, and agitation). Finally examples of integrated process for generation cardiomyocytes (CM) and neural progenitor cells (NPC) as well as challenges to be solved are described. - Highlights: • Expansion of hPSC on microcarriers. • Differentiation of hPSC on microcarriers. • Parameters that can affect the expansion and differentiation of hPSC on microcarriers. • Integration of expansion and differentiation of hPSC on microcarriers in one unit operation.

  4. Integrated processes for expansion and differentiation of human pluripotent stem cells in suspended microcarriers cultures

    Energy Technology Data Exchange (ETDEWEB)

    Lam, Alan Tin-Lun, E-mail: alan_lam@bti.a-star.edu.sg; Chen, Allen Kuan-Liang; Ting, Sherwin Qi-Peng; Reuveny, Shaul; Oh, Steve Kah-Weng, E-mail: steve_oh@bti.a-star.edu.sg

    2016-05-06

    Current methods for human pluripotent stem cells (hPSC) expansion and differentiation can be limited in scalability and costly (due to their labor intensive nature). This can limit their use in cell therapy, drug screening and toxicity assays. One of the approaches that can overcome these limitations is microcarrier (MC) based cultures in which cells are expanded as cell/MC aggregates and then directly differentiated as embryoid bodies (EBs) in the same agitated reactor. This integrated process can be scaled up and eliminate the need for some culture manipulation used in common monolayer and EBs cultures. This review describes the principles of such microcarriers based integrated hPSC expansion and differentiation process, and parameters that can affect its efficiency (such as MC type and extracellular matrix proteins coatings, cell/MC aggregates size, and agitation). Finally examples of integrated process for generation cardiomyocytes (CM) and neural progenitor cells (NPC) as well as challenges to be solved are described. - Highlights: • Expansion of hPSC on microcarriers. • Differentiation of hPSC on microcarriers. • Parameters that can affect the expansion and differentiation of hPSC on microcarriers. • Integration of expansion and differentiation of hPSC on microcarriers in one unit operation.

  5. Semi-industrial experimental study on bauxite separation using a cell-column integration process

    Science.gov (United States)

    Zhang, Ning-ning; Zhou, Chang-chun; Cong, Long-fei; Cao, Wen-long; Zhou, You

    2016-01-01

    The cyclonic-static micro-bubble flotation column (FCSMC) is a highly efficient mineral processing equipment. In this study, a cell-column (FCSMC) integration process was investigated for the separation of bauxite and its feasibility was analyzed on a theoretical basis. The properties of low-grade bauxite ore from Henan Province, China were analyzed. Parameters such as reagent dosage, scraping bubble time, and pressure of the circulating pump during the sorting process were investigated and optimized to improve the flotation efficiency. On the basis of these parameters, continuous separation experiments were conducted. Bauxite concentrate with an aluminum-to-silicon (A/S) mass ratio of 6.37 and a 77.63wt% recovery rate were achieved via a flow sheet consisting of "fast flotation using a flotation cell, one roughing flotation and one cleaning flotation using flotation columns". Compared with the full-flotation-cells process, the cell-column integration process resulted in an increase of the A/S ratio by 0.41 and the recovery rate by 17.58wt%. Cell-column integration separation technology represents a new approach for the separation of middle-to-low-grade bauxite ore.

  6. Exploring continuous and integrated strategies for the up- and downstream processing of human mesenchymal stem cells.

    Science.gov (United States)

    Cunha, Bárbara; Aguiar, Tiago; Silva, Marta M; Silva, Ricardo J S; Sousa, Marcos F Q; Pineda, Earl; Peixoto, Cristina; Carrondo, Manuel J T; Serra, Margarida; Alves, Paula M

    2015-11-10

    The integration of up- and downstream unit operations can result in the elimination of hold steps, thus decreasing the footprint, and ultimately can create robust closed system operations. This type of design is desirable for the bioprocess of human mesenchymal stem cells (hMSC), where high numbers of pure cells, at low volumes, need to be delivered for therapy applications. This study reports a proof of concept of the integration of a continuous perfusion culture in bioreactors with a tangential flow filtration (TFF) system for the concentration and washing of hMSC. Moreover, we have also explored a continuous alternative for concentrating hMSC. Results show that expanding cells in a continuous perfusion operation mode provided a higher expansion ratio, and led to a shift in cells' metabolism. TFF operated either in continuous or discontinuous allowed to concentrate cells, with high cell recovery (>80%) and viability (>95%); furthermore, continuous TFF permitted to operate longer with higher cell concentrations. Continuous diafiltration led to higher protein clearance (98%) with lower cell death, when comparing to discontinuous diafiltration. Overall, an integrated process allowed for a shorter process time, recovering 70% of viable hMSC (>95%), with no changes in terms of morphology, immunophenotype, proliferation capacity and multipotent differentiation potential. Copyright © 2015 Elsevier B.V. All rights reserved.

  7. The Integrated Renovation Process

    DEFF Research Database (Denmark)

    Galiotto, Nicolas; Heiselberg, Per; Knudstrup, Mary-Ann

    The Integrated Renovation Process (IRP) is a user customized methodology based on judiciously selected constructivist and interactive multi-criteria decision making methods (Galiotto, Heiselberg, & Knudstrup, 2014 (expected)). When applied for home renovation, the Integrated Renovation Process...

  8. Integrated hydrogen production process from cellulose by combining dark fermentation, microbial fuel cells, and a microbial electrolysis cell

    KAUST Repository

    Wang, Aijie

    2011-03-01

    Hydrogen gas production from cellulose was investigated using an integrated hydrogen production process consisting of a dark fermentation reactor and microbial fuel cells (MFCs) as power sources for a microbial electrolysis cell (MEC). Two MFCs (each 25mL) connected in series to an MEC (72mL) produced a maximum of 0.43V using fermentation effluent as a feed, achieving a hydrogen production rate from the MEC of 0.48m 3 H 2/m 3/d (based on the MEC volume), and a yield of 33.2mmol H 2/g COD removed in the MEC. The overall hydrogen production for the integrated system (fermentation, MFC and MEC) was increased by 41% compared with fermentation alone to 14.3mmol H 2/g cellulose, with a total hydrogen production rate of 0.24m 3 H 2/m 3/d and an overall energy recovery efficiency of 23% (based on cellulose removed) without the need for any external electrical energy input. © 2010 Elsevier Ltd.

  9. Integrated hydrogen production process from cellulose by combining dark fermentation, microbial fuel cells, and a microbial electrolysis cell.

    Science.gov (United States)

    Wang, Aijie; Sun, Dan; Cao, Guangli; Wang, Haoyu; Ren, Nanqi; Wu, Wei-Min; Logan, Bruce E

    2011-03-01

    Hydrogen gas production from cellulose was investigated using an integrated hydrogen production process consisting of a dark fermentation reactor and microbial fuel cells (MFCs) as power sources for a microbial electrolysis cell (MEC). Two MFCs (each 25 mL) connected in series to an MEC (72 mL) produced a maximum of 0.43 V using fermentation effluent as a feed, achieving a hydrogen production rate from the MEC of 0.48 m(3) H(2)/m(3)/d (based on the MEC volume), and a yield of 33.2 mmol H(2)/g COD removed in the MEC. The overall hydrogen production for the integrated system (fermentation, MFC and MEC) was increased by 41% compared with fermentation alone to 14.3 mmol H(2)/g cellulose, with a total hydrogen production rate of 0.24 m(3) H(2)/m(3)/d and an overall energy recovery efficiency of 23% (based on cellulose removed) without the need for any external electrical energy input. Copyright © 2010 Elsevier Ltd. All rights reserved.

  10. Silicon integrated circuit process

    International Nuclear Information System (INIS)

    Lee, Jong Duck

    1985-12-01

    This book introduces the process of silicon integrated circuit. It is composed of seven parts, which are oxidation process, diffusion process, ion implantation process such as ion implantation equipment, damage, annealing and influence on manufacture of integrated circuit and device, chemical vapor deposition process like silicon Epitaxy LPCVD and PECVD, photolithography process, including a sensitizer, spin, harden bake, reflection of light and problems related process, infrared light bake, wet-etch, dry etch, special etch and problems of etching, metal process like metal process like metal-silicon connection, aluminum process, credibility of aluminum and test process.

  11. Silicon integrated circuit process

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jong Duck

    1985-12-15

    This book introduces the process of silicon integrated circuit. It is composed of seven parts, which are oxidation process, diffusion process, ion implantation process such as ion implantation equipment, damage, annealing and influence on manufacture of integrated circuit and device, chemical vapor deposition process like silicon Epitaxy LPCVD and PECVD, photolithography process, including a sensitizer, spin, harden bake, reflection of light and problems related process, infrared light bake, wet-etch, dry etch, special etch and problems of etching, metal process like metal process like metal-silicon connection, aluminum process, credibility of aluminum and test process.

  12. Integrated Renovation Process

    DEFF Research Database (Denmark)

    Galiotto, Nicolas; Heiselberg, Per; Knudstrup, Mary-Ann

    2016-01-01

    renovation to be overcome. The homeowners were better integrated and their preferences and immaterial values were better taken into account. To keep the decision-making process economically viable and timely, the process as known today still needs to be improved, and new tools need to be developed....... This paper presents a new scheme: the integrated renovation process. One successful case study is introduced, and recommendations for future developments needed in the field are provided....

  13. Integrated circuit cell library

    Science.gov (United States)

    Whitaker, Sterling R. (Inventor); Miles, Lowell H. (Inventor)

    2005-01-01

    According to the invention, an ASIC cell library for use in creation of custom integrated circuits is disclosed. The ASIC cell library includes some first cells and some second cells. Each of the second cells includes two or more kernel cells. The ASIC cell library is at least 5% comprised of second cells. In various embodiments, the ASIC cell library could be 10% or more, 20% or more, 30% or more, 40% or more, 50% or more, 60% or more, 70% or more, 80% or more, 90% or more, or 95% or more comprised of second cells.

  14. Hydrogen production from sugar beet juice using an integrated biohydrogen process of dark fermentation and microbial electrolysis cell.

    Science.gov (United States)

    Dhar, Bipro Ranjan; Elbeshbishy, Elsayed; Hafez, Hisham; Lee, Hyung-Sool

    2015-12-01

    An integrated dark fermentation and microbial electrochemical cell (MEC) process was evaluated for hydrogen production from sugar beet juice. Different substrate to inoculum (S/X) ratios were tested for dark fermentation, and the maximum hydrogen yield was 13% of initial COD at the S/X ratio of 2 and 4 for dark fermentation. Hydrogen yield was 12% of initial COD in the MEC using fermentation liquid end products as substrate, and butyrate only accumulated in the MEC. The overall hydrogen production from the integrated biohydrogen process was 25% of initial COD (equivalent to 6 mol H2/mol hexoseadded), and the energy recovery from sugar beet juice was 57% using the combined biohydrogen. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. The Integrated Renovation Process

    DEFF Research Database (Denmark)

    Galiotto, Nicolas

    and constructivist multiple criteria decision-making analysis method is selected for developing the work further. The method is introduced and applied to the renovation of a multi-residential historic building. Furthermore, a new scheme, the Integrated Renovation Process, is presented. Finally, the methodology...... is applied to two single-family homes. In practice, such a scheme allowed most informational barriers to sustainable home renovation to be overcome. The homeowners were better integrated and their preferences and immaterial values were better taken into account. They assimilated the multiple benefits...... to keep the decision making process economically viable and timely, the process still needs to be improved and new tools need to be developed....

  16. Nano integrated circuit process

    International Nuclear Information System (INIS)

    Yoon, Yung Sup

    2004-02-01

    This book contains nine chapters, which are introduction of manufacture of semiconductor chip, oxidation such as Dry-oxidation, wet oxidation, oxidation model and oxide film, diffusion like diffusion process, diffusion equation, diffusion coefficient and diffusion system, ion implantation, including ion distribution, channeling, multiimplantation and masking and its system, sputtering such as CVD and PVD, lithography, wet etch and dry etch, interconnection and flattening like metal-silicon connection, silicide, multiple layer metal process and flattening, an integrated circuit process, including MOSFET and CMOS.

  17. Nano integrated circuit process

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Yung Sup

    2004-02-15

    This book contains nine chapters, which are introduction of manufacture of semiconductor chip, oxidation such as Dry-oxidation, wet oxidation, oxidation model and oxide film, diffusion like diffusion process, diffusion equation, diffusion coefficient and diffusion system, ion implantation, including ion distribution, channeling, multiimplantation and masking and its system, sputtering such as CVD and PVD, lithography, wet etch and dry etch, interconnection and flattening like metal-silicon connection, silicide, multiple layer metal process and flattening, an integrated circuit process, including MOSFET and CMOS.

  18. Integrated cell and process engineering for improved transient production of a "difficult-to-express" fusion protein by CHO cells.

    Science.gov (United States)

    Johari, Yusuf B; Estes, Scott D; Alves, Christina S; Sinacore, Marty S; James, David C

    2015-12-01

    Based on an optimized electroporation protocol, we designed a rapid, milliliter-scale diagnostic transient production assay to identify limitations in the ability of Chinese hamster ovary (CHO) cells to produce a model "difficult-to-express" homodimeric Fc-fusion protein, Sp35Fc, that exhibited very low volumetric titer and intracellular formation of disulfide-bonded oligomeric aggregates post-transfection. As expression of Sp35Fc induced an unfolded protein response in transfected host cells, we utilized the transient assay to compare, in parallel, multiple functionally diverse strategies to engineer intracellular processing of Sp35Fc in order to increase production and reduce aggregation as two discrete design objectives. Specifically, we compared the effect of (i) co-expression of ER-resident molecular chaperones (BiP, PDI, CypB) or active forms of UPR transactivators (ATF6c, XBP1s) at varying recombinant gene load, (ii) addition of small molecules known to act as chemical chaperones (PBA, DMSO, glycerol, betaine, TMAO) or modulate UPR signaling (PERK inhibitor GSK2606414) at varying concentration, (iii) a reduction in culture temperature to 32°C. Using this information, we designed a biphasic, Sp35Fc-specific transient manufacturing process mediated by lipofection that utilized CypB co-expression at an optimal Sp35Fc:CypB gene ratio of 5:1 to initially maximize transfected cell proliferation, followed by addition of a combination of PBA (0.5 mM) and glycerol (1% v/v) at the onset of stationary phase to maximize cell specific production and eliminate Sp35Fc aggregation. Using this optimal, engineered process transient Sp35Fc production was significantly increased sixfold over a 12 day production process with no evidence of disulfide-bonded aggregates. Finally, transient production in clonally derived sub-populations (derived from parental CHO host) screened for a heritably improved capability to produce Sp35Fc was also significantly improved by the optimized

  19. Integration of Aqueous Two-Phase Extraction as Cell Harvest and Capture Operation in the Manufacturing Process of Monoclonal Antibodies

    Directory of Open Access Journals (Sweden)

    Axel Schmidt

    2017-12-01

    Full Text Available Substantial improvements have been made to cell culturing processes (e.g., higher product titer in recent years by raising cell densities and optimizing cultivation time. However, this has been accompanied by an increase in product-related impurities and therefore greater challenges in subsequent clarification and capture operations. Considering the paradigm shift towards the design of continuously operating dedicated plants at smaller scales—with or without disposable technology—for treating smaller patient populations due to new indications or personalized medicine approaches, the rising need for new, innovative strategies for both clarification and capture technology becomes evident. Aqueous two-phase extraction (ATPE is now considered to be a feasible unit operation, e.g., for the capture of monoclonal antibodies or recombinant proteins. However, most of the published work so far investigates the applicability of ATPE in antibody-manufacturing processes at the lab-scale and for the most part, only during the capture step. This work shows the integration of ATPE as a combined harvest and capture step into a downstream process. Additionally, a model is applied that allows early prediction of settler dimensions with high prediction accuracy. Finally, a reliable process development concept, which guides through the necessary steps, starting from the definition of the separation task to the final stages of integration and scale-up, is presented.

  20. Integrated biofuels process synthesis

    DEFF Research Database (Denmark)

    Torres-Ortega, Carlo Edgar; Rong, Ben-Guang

    2017-01-01

    Second and third generation bioethanol and biodiesel are more environmentally friendly fuels than gasoline and petrodiesel, andmore sustainable than first generation biofuels. However, their production processes are more complex and more expensive. In this chapter, we describe a two-stage synthesis......% used for bioethanol process), and steam and electricity from combustion (54%used as electricity) in the bioethanol and biodiesel processes. In the second stage, we saved about 5% in equipment costs and 12% in utility costs for bioethanol separation. This dual synthesis methodology, consisting of a top......-level screening task followed by a down-level intensification task, proved to be an efficient methodology for integrated biofuel process synthesis. The case study illustrates and provides important insights into the optimal synthesis and intensification of biofuel production processes with the proposed synthesis...

  1. An Integrated Desgin Process

    DEFF Research Database (Denmark)

    Petersen, Mads Dines; Knudstrup, Mary-Ann

    2010-01-01

    Present paper is placed in the discussion about how sustainable measures are integrated in the design process by architectural offices. It presents results from interviews with four leading Danish architectural offices working with sustainable architecture and their experiences with it, as well...... as the requirements they meet in terms of how to approach the design process – especially focused on the early stages like a competition. The interviews focus on their experiences with working in multidisciplinary teams and using digital tools to support their work with sustainable issues. The interviews show...... the environmental measures cannot be discarded due to extra costs....

  2. An Integrated Design Process

    DEFF Research Database (Denmark)

    Petersen, Mads Dines; Knudstrup, Mary-Ann

    2010-01-01

    Present paper is placed in the discussion about how sustainable measures are integrated in the design process by architectural offices. It presents results from interviews with four leading Danish architectural offices working with sustainable architecture and their experiences with it, as well...... as the requirements they meet in terms of how to approach the design process – especially focused on the early stages like a competition. The interviews focus on their experiences with working in multidisciplinary teams and using digital tools to support their work with sustainable issues. The interviews show...... the environmental measures cannot be discarded due to extra costs....

  3. Exergy analysis of the biogas sorption-enhanced chemical looping reforming process integrated with a high-temperature proton exchange membrane fuel cell

    International Nuclear Information System (INIS)

    Kasemanand, Sarunyou; Im-orb, Karittha; Tippawan, Phanicha; Wiyaratn, Wisitsree; Arpornwichanop, Amornchai

    2017-01-01

    Highlights: • A biogas reforming and fuel cell integrated process is considered. • Energy and exergy analyses of the integrated process are performed. • Increasing the nickel oxide-to-biogas ratio decreases the exergy efficiency. • The exergy destruction of the fuel cell increases with increasing cell temperature. • The exergy efficiency of the process is improved when heat integration is applied. - Abstract: A biogas sorption-enhanced chemical looping reforming process integrated with a high-temperature proton exchange membrane fuel cell is analyzed. Modeling of such an integrated process is performed by using a flowsheet simulator (Aspen plus). The exergy analysis is performed to evaluate the energy utilization efficiency of each unit and that of the integrated process. The effect of steam and nickel oxide to biogas ratios on the exergetic performance of the stand-alone biogas sorption-enhanced chemical looping reforming process is investigated. The total exergy destruction increases as the steam or nickel oxide to biogas ratio increases. The main exergy destruction is found at the air reactor. For the high-temperature proton exchange membrane fuel cell, the main exergy destruction is found at the cathode. The total exergy destruction increases when cell temperature increases, whereas the inverse effect is found when the current density is considered as a key parameter. Regarding the exergy efficiency, the results show opposite trend to the exergy destruction. The heat integration analysis is performed to improve the exergetic performance. It is found that the integrated process including the heat integration system can improve the exergy destruction and exergy efficiency of 48% and 60%, respectively.

  4. The Integrated Renovation Process

    DEFF Research Database (Denmark)

    Galiotto, Nicolas; Heiselberg, Per; Knudstrup, Mary-Ann

    they get more time for the cost optimization and the qualitative analysis of the users’ needs and behaviours. In order to reach a fossil free energy building stock within an acceptable time frame, it is primordial that researchers, politicians and the building industry work hand in hand. Indeed, in order...... to overcome the financial barriers to energy renovation and bring a new type of building experts in the building renovation sector, cost optimization tools for building renovation have been and can be developed but new legislation and politico-economic supports are still much needed. We present in this report...... a new contribution from the research and industry sides and results reached with the newly developed methodology, but without a significant contribution from the politico-economic and legislation sides . The experiences met during application of the Integrated Renovation Process are described...

  5. Buried waste integrated demonstration technology integration process

    International Nuclear Information System (INIS)

    Ferguson, J.S.; Ferguson, J.E.

    1992-04-01

    A Technology integration Process was developed for the Idaho National Energy Laboratories (INEL) Buried Waste Integrated Demonstration (BWID) Program to facilitate the transfer of technology and knowledge from industry, universities, and other Federal agencies into the BWID; to successfully transfer demonstrated technology and knowledge from the BWID to industry, universities, and other Federal agencies; and to share demonstrated technologies and knowledge between Integrated Demonstrations and other Department of Energy (DOE) spread throughout the DOE Complex. This document also details specific methods and tools for integrating and transferring technologies into or out of the BWID program. The document provides background on the BWID program and technology development needs, demonstrates the direction of technology transfer, illustrates current processes for this transfer, and lists points of contact for prospective participants in the BWID technology transfer efforts. The Technology Integration Process was prepared to ensure compliance with the requirements of DOE's Office of Technology Development (OTD)

  6. Human-Systems Integration Processes

    Data.gov (United States)

    National Aeronautics and Space Administration — The goal of this project is to baseline a Human-Systems Integration Processes (HSIP) document as a companion to the NASA-STD-3001 and Human Integration Design...

  7. Towards Cost-Effective Crystalline Silicon Based Flexible Solar Cells: Integration Strategy by Rational Design of Materials, Process, and Devices

    KAUST Repository

    Bahabry, Rabab R.

    2017-11-30

    The solar cells market has an annual growth of more than 30 percent over the past 15 years. At the same time, the cost of the solar modules diminished to meet both of the rapid global demand and the technological improvements. In particular for the crystalline silicon solar cells, the workhorse of this technology. The objective of this doctoral thesis is enhancing the efficiency of c-Si solar cells while exploring the cost reduction via innovative techniques. Contact metallization and ultra-flexible wafer based c-Si solar cells are the main areas under investigation. First, Silicon-based solar cells typically utilize screen printed Silver (Ag) metal contacts which affect the optimal electrical performance. To date, metal silicide-based ohmic contacts are occasionally used for the front contact grid lines. In this work, investigation of the microstructure and the electrical characteristics of nickel monosilicide (NiSi) ohmic contacts on the rear side of c-Si solar cells has been carried out. Significant enhancement in the fill factor leading to increasing the total power conversion efficiency is observed. Second, advanced classes of modern application require a new generation of versatile solar cells showcasing extreme mechanical resilience. However, silicon is a brittle material with a fracture strains <1%. Highly flexible Si-based solar cells are available in the form thin films which seem to be disadvantageous over thick Si solar cells due to the reduction of the optical absorption with less active Si material. Here, a complementary metal oxide semiconductor (CMOS) technology based integration strategy is designed where corrugation architecture to enable an ultra-flexible solar cell module from bulk mono-crystalline silicon solar wafer with 17% efficiency. This periodic corrugated array benefits from an interchangeable solar cell segmentation scheme which preserves the active silicon thickness and achieves flexibility via interdigitated back contacts. These cells

  8. Biochemical Process Development and Integration | Bioenergy | NREL

    Science.gov (United States)

    Biochemical Process Development and Integration Biochemical Process Development and Integration Our conversion and separation processes to pilot-scale integrated process development and scale up. We also Publications Accounting for all sugar produced during integrated production of ethanol from lignocellulosic

  9. Integrated Optical Information Processing

    Science.gov (United States)

    1988-08-01

    applications in optical disk memory systems [91. This device is constructed in a glass /SiO2/Si waveguide. The choice of a Si substrate allows for the...contact mask) were formed in the photoresist deposited on all of the samples, we covered the unwanted gratings on each sample with cover glass slides...processing, let us consider TeO2 (v, = 620 m/s) as a potential substrate for applications requiring large time delays. This con- sideration is despite

  10. Integrated process status overview

    International Nuclear Information System (INIS)

    Gertman, D.I.; Gaudio, P. Jr.

    1986-01-01

    This report summarizes findings to date with the IPSO, a large plant status overview currently under development at the OECD Halden Reactor Project. As part of a joint Halden and Combustion Engineering project, the overview is being tested in part to determine whether the large screen overview concept being entertained for use in the nuclear power plant (NPP) industry will facilitate operator performance. To this end an interactive simulation technique was used to establish a proof-of-principle test for the IPSO. Process control, operations, and human factors experts at Halden participated in the test and evaluation

  11. Integrated stationary Ornstein-Uhlenbeck process, and double integral processes

    Science.gov (United States)

    Abundo, Mario; Pirozzi, Enrica

    2018-03-01

    We find a representation of the integral of the stationary Ornstein-Uhlenbeck (ISOU) process in terms of Brownian motion Bt; moreover, we show that, under certain conditions on the functions f and g , the double integral process (DIP) D(t) = ∫βt g(s) (∫αs f(u) dBu) ds can be thought as the integral of a suitable Gauss-Markov process. Some theoretical and application details are given, among them we provide a simulation formula based on that representation by which sample paths, probability densities and first passage times of the ISOU process are obtained; the first-passage times of the DIP are also studied.

  12. Teaching Process Design through Integrated Process Synthesis

    Science.gov (United States)

    Metzger, Matthew J.; Glasser, Benjamin J.; Patel, Bilal; Hildebrandt, Diane; Glasser, David

    2012-01-01

    The design course is an integral part of chemical engineering education. A novel approach to the design course was recently introduced at the University of the Witwatersrand, Johannesburg, South Africa. The course aimed to introduce students to systematic tools and techniques for setting and evaluating performance targets for processes, as well as…

  13. The LEAN Payload Integration Process

    Science.gov (United States)

    Jordan, Lee P.; Young, Yancy; Rice, Amanda

    2011-01-01

    It is recognized that payload development and integration with the International Space Station (ISS) can be complex. This streamlined integration approach is a first step toward simplifying payload integration; making it easier to fly payloads on ISS, thereby increasing feasibility and interest for more research and commercial organizations to sponsor ISS payloads and take advantage of the ISS as a National Laboratory asset. The streamlined integration approach was addressed from the perspective of highly likely initial payload types to evolve from the National Lab Pathfinder program. Payloads to be accommodated by the Expedite the Processing of Experiments for Space Station (EXPRESS) Racks and Microgravity Sciences Glovebox (MSG) pressurized facilities have been addressed. It is hoped that the streamlined principles applied to these types of payloads will be analyzed and implemented in the future for other host facilities as well as unpressurized payloads to be accommodated by the EXPRESS Logistics Carrier (ELC). Further, a payload does not have to be classified as a National Lab payload in order to be processed according to the lean payload integration process; any payload that meets certain criteria can follow the lean payload integration process.

  14. Process integration and optimization of a solid oxide fuel cell – Gas turbine hybrid cycle fueled with hydrothermally gasified waste biomass

    International Nuclear Information System (INIS)

    Facchinetti, Emanuele; Gassner, Martin; D’Amelio, Matilde; Marechal, François; Favrat, Daniel

    2012-01-01

    Due to its suitability for using wet biomass, hydrothermal gasification is a promising process for the valorization of otherwise unused waste biomass to synthesis gas and biofuels. Solid oxide fuel cell (SOFC) based hybrid cycles are considered as the best candidate for a more efficient and clean conversion of (bio) fuels. A significant potential for the integration of the two technologies is expected since hydrothermal gasification requires heat at 673–773 K, whereas SOFC is characterized by heat excess at high temperature due to the limited electrochemical fuel conversion. This work presents a systematic process integration and optimization of a SOFC-gas turbine (GT) hybrid cycle fueled with hydrothermally gasified waste biomass. Several design options are systematically developed and compared through a thermodynamic optimization approach based on First Law and exergy analysis. The work demonstrates the considerable potential of the system that allows for converting wet waste biomass into electricity at a First Law efficiency of up to 63%, while simultaneously enabling the separation of biogenic carbon dioxide for further use or sequestration. -- Highlights: ► Hydrothermal gasification is a promising process for the valorization of waste wet biomass. ► Solid Oxide Fuel Cell – Gas Turbine hybrid cycle emerges as the best candidates for conversion of biofuels. ► A systematic process integration and optimization of a SOFC-GT hybrid cycle fuelled with hydrothermally gasified biomass is presented. ► The system may convert wet waste biomass to electricity at a First Law efficiency of 63% while separating the biogenic carbon dioxide. ► The process integration enables to improve the First Law efficiency of around 4% with respect to a non-integrated system.

  15. Fed-batch hydrolysate addition and cell separation by settling in high cell density lignocellulosic ethanol fermentations on AFEX™ corn stover in the Rapid Bioconversion with Integrated recycling Technology process.

    Science.gov (United States)

    Sarks, Cory; Jin, Mingjie; Balan, Venkatesh; Dale, Bruce E

    2017-09-01

    The Rapid Bioconversion with Integrated recycling Technology (RaBIT) process uses enzyme and yeast recycling to improve cellulosic ethanol production economics. The previous versions of the RaBIT process exhibited decreased xylose consumption using cell recycle for a variety of different micro-organisms. Process changes were tested in an attempt to eliminate the xylose consumption decrease. Three different RaBIT process changes were evaluated in this work including (1) shortening the fermentation time, (2) fed-batch hydrolysate addition, and (3) selective cell recycling using a settling method. Shorting the RaBIT fermentation process to 11 h and introducing fed-batch hydrolysate addition eliminated any xylose consumption decrease over ten fermentation cycles; otherwise, decreased xylose consumption was apparent by the third cell recycle event. However, partial removal of yeast cells during recycle was not economical when compared to recycling all yeast cells.

  16. Human Integration Design Processes (HIDP)

    Science.gov (United States)

    Boyer, Jennifer

    2014-01-01

    The purpose of the Human Integration Design Processes (HIDP) document is to provide human-systems integration design processes, including methodologies and best practices that NASA has used to meet human systems and human rating requirements for developing crewed spacecraft. HIDP content is framed around human-centered design methodologies and processes in support of human-system integration requirements and human rating. NASA-STD-3001, Space Flight Human-System Standard, is a two-volume set of National Aeronautics and Space Administration (NASA) Agency-level standards established by the Office of the Chief Health and Medical Officer, directed at minimizing health and performance risks for flight crews in human space flight programs. Volume 1 of NASA-STD-3001, Crew Health, sets standards for fitness for duty, space flight permissible exposure limits, permissible outcome limits, levels of medical care, medical diagnosis, intervention, treatment and care, and countermeasures. Volume 2 of NASASTD- 3001, Human Factors, Habitability, and Environmental Health, focuses on human physical and cognitive capabilities and limitations and defines standards for spacecraft (including orbiters, habitats, and suits), internal environments, facilities, payloads, and related equipment, hardware, and software with which the crew interfaces during space operations. The NASA Procedural Requirements (NPR) 8705.2B, Human-Rating Requirements for Space Systems, specifies the Agency's human-rating processes, procedures, and requirements. The HIDP was written to share NASA's knowledge of processes directed toward achieving human certification of a spacecraft through implementation of human-systems integration requirements. Although the HIDP speaks directly to implementation of NASA-STD-3001 and NPR 8705.2B requirements, the human-centered design, evaluation, and design processes described in this document can be applied to any set of human-systems requirements and are independent of reference

  17. Integration process and logistics results

    International Nuclear Information System (INIS)

    2004-01-01

    The Procurement and Logistics functions have gone through a process of integration since the beginning of integrated management of Asco and Vandellos II up to the present. These are functions that are likely to be designed for delivering a single product to the rest of the organization, defined from a high level of expectations, and that admit simplifications and materialization of synergy's as they are approached from an integrated perspective. The analyzed functions are as follows: Service and Material Purchasing, Warehouse and Material Management, and Documentation and General Services Management. In all case, to accomplish the integration, objectives, procedures and information systems were unified. As for the organization, a decision was made in each case on whether or not to out source. The decisive corporate strategy to integrate, resulting in actions such as moving corporate headquarters to Vandellos II, corporate consolidation, regulation of employment and implementation of the ENDESA Group Economic Information System (SIE) , has shaped this process, which at present can be considered as practically complete. (Author)

  18. A Preliminary Shielding Study on the Integrated Operation Verification System in the Head-End Hot-Cell of the Pyro-processing

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jinhwam; Kim, Yewon; Park, Se-Hwan; Ahn, Seong-Kyu; Cho, Gyuseong [KAIST, Daejeon (Korea, Republic of)

    2016-10-15

    Nuclear power accounts for more than 30 percent of power production in Korea. Its significance has annually been increased. Disposal spent fuel containing uranium, transuranic elements, and fission products is unavoidable byproduct of nuclear power production. it is recognized that finding appropriate sites for interim storage of disposal spent fuel is not easy because isolated sites should be required. Pyro-processing technology, Pyro-processing should be operated under high radiation environment in hot-cell structures. Because of this reason, all workers should be unauthorized to access inside the hot-cell areas under any circumstances except for acceptable dose verification and a normal operation should be remotely manipulated. For the reliable normal operation of pyroprocessing, it is noted that an evaluation of the space dose distribution in the hot-cell environments is necessary in advance in order to determine which technologies or instruments can be utilized on or near the process as the Integrated Operation Verification System (IOVS) is measured. Not like the electroreduction and electro-refining hot-cells, the head-end hot-cell equips Camera Radiation Detector (CRD) in which plutonium is securely measured and monitored for the safeguard of the pyro-processing. Results have been obtained using F2 surface tally in order to observe the magnitude of the gamma-ray and neutron flux which pass through the surface of the process cell. Furthermore, T-mesh tally has also been used to obtain the space dose distribution in the headend hot-cell. The hot-cell was divided into 7,668 cells in which each dimension was 1 x 1 x 1m for the T-mesh tally. To determine the position of the CRD and the surveillance camera, divergent approaches were required. Because the purpose of the CRD which contains a gamma-ray detector and a neutron detector is to identify the material composition as the process proceeds, the position in which detectable flux is exposed is required, whereas

  19. Towards Cost-Effective Crystalline Silicon Based Flexible Solar Cells: Integration Strategy by Rational Design of Materials, Process, and Devices

    KAUST Repository

    Bahabry, Rabab R.

    2017-01-01

    . However, silicon is a brittle material with a fracture strains <1%. Highly flexible Si-based solar cells are available in the form thin films which seem to be disadvantageous over thick Si solar cells due to the reduction of the optical absorption

  20. Logistics integration processes in the food industry

    OpenAIRE

    Giménez, Cristina

    2003-01-01

    This paper analyses the integration process that firms follow to implement Supply Chain Management (SCM). This study has been inspired in the integration model proposed by Stevens (1989). He suggests that companies internally integrate first and then extend integration to other supply chain members, such as customers and suppliers. To analyse the integration process a survey was conducted among Spanish food manufacturers. The results show that there are companies in three different integratio...

  1. Low cost back contact heterojunction solar cells on thin c-Si wafers. integrating laser and thin film processing for improved manufacturability

    Energy Technology Data Exchange (ETDEWEB)

    Hegedus, Steven S. [Univ. of Delaware, Newark, DE (United States)

    2015-09-08

    An interdigitated back contact (IBC) Si wafer solar cell with deposited a-Si heterojunction (HJ) emitter and contacts is considered the ultimate single junction Si solar cell design. This was confirmed in 2014 by both Panasonic and Sharp Solar producing IBC-HJ cells breaking the previous record Si solar cell efficiency of 25%. But manufacturability at low cost is a concern for the complex IBC-HJ device structure. In this research program, our goals were to addressed the broad industry need for a high-efficiency c-Si cell that overcomes the dominant module cost barriers by 1) developing thin Si wafers synthesized by innovative, kerfless techniques; 2) integrating laser-based processing into most aspects of solar cell fabrication, ensuring high speed and low thermal budgets ; 3) developing an all back contact cell structure compatible with thin wafers using a simplified, low-temperature fabrication process; and 4) designing the contact patterning to enable simplified module assembly. There were a number of significant achievements from this 3 year program. Regarding the front surface, we developed and applied new method to characterize critical interface recombination parameters including interface defect density Dit and hole and electron capture cross-section for use as input for 2D simulation of the IBC cell to guide design and loss analysis. We optimized the antireflection and passivation properties of the front surface texture and a-Si/a-SiN/a-SiC stack depositions to obtain a very low (< 6 mA/cm2) front surface optical losses (reflection and absorption) while maintaining excellent surface passivation (SRV<5 cm/s). We worked with kerfless wafer manufacturers to apply defect-engineering techniques to improve bulk minority-carrier lifetime of thin kerfless wafers by both reducing initial impurities during growth and developing post-growth gettering techniques. This led insights about the kinetics of nickel, chromium, and dislocations in PV-grade silicon and to

  2. Low cost back contact heterojunction solar cells on thin c-Si wafers. Integrating laser and thin film processing for improved manufacturability

    Energy Technology Data Exchange (ETDEWEB)

    Hegedus, Steven S. [Univ. of Delaware, Newark, DE (United States)

    2015-09-08

    An interdigitated back contact (IBC) Si wafer solar cell with deposited a-Si heterojunction (HJ) emitter and contacts is considered the ultimate single junction Si solar cell design. This was confirmed in 2014 by both Panasonic and Sharp Solar producing IBC-HJ cells breaking the previous record Si solar cell efficiency of 25%. But manufacturability at low cost is a concern for the complex IBC-HJ device structure. In this research program, our goals were to addressed the broad industry need for a high-efficiency c-Si cell that overcomes the dominant module cost barriers by 1) developing thin Si wafers synthesized by innovative, kerfless techniques; 2) integrating laser-based processing into most aspects of solar cell fabrication, ensuring high speed and low thermal budgets ; 3) developing an all back contact cell structure compatible with thin wafers using a simplified, low-temperature fabrication process; and 4) designing the contact patterning to enable simplified module assembly. There were a number of significant achievements from this 3 year program. Regarding the front surface, we developed and applied new method to characterize critical interface recombination parameters including interface defect density Dit and hole and electron capture cross-section for use as input for 2D simulation of the IBC cell to guide design and loss analysis. We optimized the antireflection and passivation properties of the front surface texture and a-Si/a-SiN/a-SiC stack depositions to obtain a very low (< 6 mA/cm2) front surface optical losses (reflection and absorption) while maintaining excellent surface passivation (SRV<5 cm/s). We worked with kerfless wafer manufacturers to apply defect-engineering techniques to improve bulk minority-carrier lifetime of thin kerfless wafers by both reducing initial impurities during growth and developing post-growth gettering techniques. This led insights about the kinetics of nickel, chromium, and dislocations in PV-grade silicon and to

  3. Integrated modelling in materials and process technology

    DEFF Research Database (Denmark)

    Hattel, Jesper Henri

    2008-01-01

    Integrated modelling of entire process sequences and the subsequent in-service conditions, and multiphysics modelling of the single process steps are areas that increasingly support optimisation of manufactured parts. In the present paper, three different examples of modelling manufacturing...... processes from the viewpoint of combined materials and process modelling are presented: solidification of thin walled ductile cast iron, integrated modelling of spray forming and multiphysics modelling of friction stir welding. The fourth example describes integrated modelling applied to a failure analysis...

  4. The Integrated Design Process (IDP)

    DEFF Research Database (Denmark)

    Hansen, Hanne Tine Ring; Knudstrup, Mary-Ann

    2005-01-01

    the different parameters and products can interact, and which consequences this would have on a project. The IDP does not ensure aesthetic or sustainable solutions, but it enables the designer to control the many parameters that must be considered and integrated in the project when creating more holistic...

  5. Integrated control system for electron beam processes

    Science.gov (United States)

    Koleva, L.; Koleva, E.; Batchkova, I.; Mladenov, G.

    2018-03-01

    The ISO/IEC 62264 standard is widely used for integration of the business systems of a manufacturer with the corresponding manufacturing control systems based on hierarchical equipment models, functional data and manufacturing operations activity models. In order to achieve the integration of control systems, formal object communication models must be developed, together with manufacturing operations activity models, which coordinate the integration between different levels of control. In this article, the development of integrated control system for electron beam welding process is presented as part of a fully integrated control system of an electron beam plant, including also other additional processes: surface modification, electron beam evaporation, selective melting and electron beam diagnostics.

  6. Product integration of compact roll-to-roll processed polymer solar cell modules: methods and manufacture using flexographic printing, slot-die coating and rotary screen printing

    DEFF Research Database (Denmark)

    Krebs, Frederik C; Fyenbo, Jan; Jørgensen, Mikkel

    2010-01-01

    The improvement of the performance of roll-to-roll processed polymer solar cell modules through miniaturization of the device outline is described. The devices were prepared using full roll-to-roll processing comprising flexographic printing, slot-die coating and rotary screen printing to create ......HT:[70]PCBM. The solar cell modules were used to demonstrate the complete manufacture of a small lamp entirely using techniques of flexible electronics. The solar cell module was used to charge a polymer lithium ion battery through a blocking diode. The entire process was fully automated...

  7. Integrated lunar materials manufacturing process

    Science.gov (United States)

    Gibson, Michael A. (Inventor); Knudsen, Christian W. (Inventor)

    1990-01-01

    A manufacturing plant and process for production of oxygen on the moon uses lunar minerals as feed and a minimum of earth-imported, process materials. Lunar feed stocks are hydrogen-reducible minerals, ilmenite and lunar agglutinates occurring in numerous, explored locations mixed with other minerals in the pulverized surface layer of lunar soil known as regolith. Ilmenite (FeTiO.sub.3) and agglutinates contain ferrous (Fe.sup.+2) iron reducible by hydrogen to yield H.sub.2 O and metallic Fe at about 700.degree.-1,200.degree. C. The H.sub.2 O is electrolyzed in gas phase to yield H.sub.2 for recycle and O.sub.2 for storage and use. Hydrogen losses to lunar vacuum are minimized, with no net hydrogen (or any other earth-derived reagent) consumption except for small leaks. Feed minerals are surface-mined by front shovels and transported in trucks to the processing area. The machines are manned or robotic. Ilmenite and agglutinates occur mixed with silicate minerals which are not hydrogen-reducible at 700.degree.-1,200.degree. C. and consequently are separated and concentrated before feeding to the oxygen generation process. Solids rejected from the separation step and reduced solids from the oxygen process are returned to the mine area. The plant is powered by nuclear or solar power generators. Vapor-phase water electrolysis, a staged, countercurrent, fluidized bed reduction reactor and a radio-frequency-driven ceramic gas heater are used to improve thermal efficiency.

  8. Developing engineering processes through integrated modelling of product and process

    DEFF Research Database (Denmark)

    Nielsen, Jeppe Bjerrum; Hvam, Lars

    2012-01-01

    This article aims at developing an operational tool for integrated modelling of product assortments and engineering processes in companies making customer specific products. Integrating a product model in the design of engineering processes will provide a deeper understanding of the engineering...... activities as well as insight into how product features affect the engineering processes. The article suggests possible ways of integrating models of products with models of engineering processes. The models have been tested and further developed in an action research study carried out in collaboration...... with a major international engineering company....

  9. Integrated durability process in product development

    International Nuclear Information System (INIS)

    Pompetzki, M.; Saadetian, H.

    2002-01-01

    This presentation describes the integrated durability process in product development. Each of the major components of the integrated process are described along with a number of examples of how integrated durability assessment has been used in the ground vehicle industry. The durability process starts with the acquisition of loading information, either physically through loads measurement or virtually through multibody dynamics. The loading information is then processed and characterized for further analysis. Durability assessment was historically test based and completed through field or laboratory evaluation. Today, it is common that both the test and CAE environments are used together in durability assessment. Test based durability assessment is used for final design sign-off but is also critically important for correlating CAE models, in order to investigate design alternatives. There is also a major initiative today to integrate the individual components into a process, by linking applications and providing a framework to communicate information as well as manage all the data involved in the entire process. Although a single process is presented, the details of the process can vary significantly for different products and applications. Recent applications that highlight different parts of the durability process are given. As well as an example of how integration of software tools between different disciplines (MBD, FE and fatigue) not only simplifies the process, but also significantly improves it. (author)

  10. Model Identification of Integrated ARMA Processes

    Science.gov (United States)

    Stadnytska, Tetiana; Braun, Simone; Werner, Joachim

    2008-01-01

    This article evaluates the Smallest Canonical Correlation Method (SCAN) and the Extended Sample Autocorrelation Function (ESACF), automated methods for the Autoregressive Integrated Moving-Average (ARIMA) model selection commonly available in current versions of SAS for Windows, as identification tools for integrated processes. SCAN and ESACF can…

  11. Poisson processes and a Bessel function integral

    NARCIS (Netherlands)

    Steutel, F.W.

    1985-01-01

    The probability of winning a simple game of competing Poisson processes turns out to be equal to the well-known Bessel function integral J(x, y) (cf. Y. L. Luke, Integrals of Bessel Functions, McGraw-Hill, New York, 1962). Several properties of J, some of which seem to be new, follow quite easily

  12. Path Integral Formulation of Anomalous Diffusion Processes

    OpenAIRE

    Friedrich, Rudolf; Eule, Stephan

    2011-01-01

    We present the path integral formulation of a broad class of generalized diffusion processes. Employing the path integral we derive exact expressions for the path probability densities and joint probability distributions for the class of processes under consideration. We show that Continuous Time Random Walks (CTRWs) are included in our framework. A closed expression for the path probability distribution of CTRWs is found in terms of their waiting time distribution as the solution of a Dyson ...

  13. Integrated Monitoring System of Production Processes

    Directory of Open Access Journals (Sweden)

    Oborski Przemysław

    2016-12-01

    Full Text Available Integrated monitoring system for discrete manufacturing processes is presented in the paper. The multilayer hardware and software reference model was developed. Original research are an answer for industry needs of the integration of information flow in production process. Reference model corresponds with proposed data model based on multilayer data tree allowing to describe orders, products, processes and save monitoring data. Elaborated models were implemented in the integrated monitoring system demonstrator developed in the project. It was built on the base of multiagent technology to assure high flexibility and openness on applying intelligent algorithms for data processing. Currently on the base of achieved experience an application integrated monitoring system for real production system is developed. In the article the main problems of monitoring integration are presented, including specificity of discrete production, data processing and future application of Cyber-Physical-Systems. Development of manufacturing systems is based more and more on taking an advantage of applying intelligent solutions into machine and production process control and monitoring. Connection of technical systems, machine tools and manufacturing processes monitoring with advanced information processing seems to be one of the most important areas of near future development. It will play important role in efficient operation and competitiveness of the whole production system. It is also important area of applying in the future Cyber-Physical-Systems that can radically improve functionally of monitoring systems and reduce the cost of its implementation.

  14. Outside-in control -Does plant cell wall integrity regulate cell cycle progression?

    Science.gov (United States)

    Gigli-Bisceglia, Nora; Hamann, Thorsten

    2018-04-13

    During recent years it has become accepted that plant cell walls are not inert objects surrounding all plant cells but are instead highly dynamic, plastic structures. They are involved in a large number of cell biological processes and contribute actively to plant growth, development and interaction with environment. Therefore, it is not surprising that cellular processes can control plant cell wall integrity while, simultaneously, cell wall integrity can influence cellular processes. In yeast and animal cells such a bi-directional relationship also exists between the yeast/animal extra-cellular matrices and the cell cycle. In yeast, the cell wall integrity maintenance mechanism and a dedicated plasmamembrane integrity checkpoint are mediating this relationship. Recent research has yielded insights into the mechanism controlling plant cell wall metabolism during cytokinesis. However, knowledge regarding putative regulatory pathways controlling adaptive modifications in plant cell cycle activity in response to changes in the state of the plant cell wall are not yet identified. In this review, we summarize similarities and differences in regulatory mechanisms coordinating extra cellular matrices and cell cycle activity in animal and yeast cells, discuss the available evidence supporting the existence of such a mechanism in plants and suggest that the plant cell wall integrity maintenance mechanism might also control cell cycle activity in plant cells. This article is protected by copyright. All rights reserved.

  15. Integrating Gene Correction in the Reprogramming and Transdifferentiation Processes: A One-Step Strategy to Overcome Stem Cell-Based Gene Therapy Limitations

    Directory of Open Access Journals (Sweden)

    Seo-Young Lee

    2016-01-01

    Full Text Available The recent advent of induced pluripotent stem cells (iPSCs and gene therapy tools has raised the possibility of autologous cell therapy for rare genetic diseases. However, cellular reprogramming is inefficient in certain diseases such as ataxia telangiectasia, Fanconi anemia, LIG4 syndrome, and fibrodysplasia ossificans progressiva syndrome, owing to interference of the disease-related genes. To overcome these therapeutic limitations, it is necessary to fundamentally correct the abnormal gene during or prior to the reprogramming process. In addition, as genetic etiology of Parkinson’s disease, it has been well known that induced neural stem cells (iNSCs were progressively depleted by LRRK2 gene mutation, LRRK2 (G2019S. Thus, to maintain the induced NSCs directly derived from PD patient cells harboring LRRK2 (G2019S, it would be ideal to simultaneously treat the LRRK2 (G2019S fibroblast during the process of TD. Therefore, simultaneous reprogramming (or TD and gene therapy would provide the solution for therapeutic limitation caused by vulnerability of reprogramming or TD, in addition to being suitable for general application to the generation of autologous cell-therapy products for patients with genetic defects, thereby obviating the need for the arduous processes currently required.

  16. Integration thermal processes through Pinch technology

    International Nuclear Information System (INIS)

    Rios H, Carlos Mario; Grisales Rincon, Rogelio; Cardona, Carlos Ariel

    2004-01-01

    This paper presents the techniques of heat integration used for process optimization, their fortresses and weaknesses during the implementation in several specific process are also discussed. It is focused to the pinch technology, explaining algorithms for method applications in the industry. The paper provides the concepts and models involved in different types of commercial software applying this method for energy cost reduction, both in design of new plants and improve of old ones. As complement to benefits of the energy cost reduction it is analysed other favorable aspects of process integration, as the emissions waste reduction and the combined heat end power systems

  17. Information Integration; The process of integration, evolution and versioning

    NARCIS (Netherlands)

    de Keijzer, Ander; van Keulen, Maurice

    2005-01-01

    At present, many information sources are available wherever you are. Most of the time, the information needed is spread across several of those information sources. Gathering this information is a tedious and time consuming job. Automating this process would assist the user in its task. Integration

  18. Integrating ergonomic knowledge into engineering design processes

    DEFF Research Database (Denmark)

    Hall-Andersen, Lene Bjerg

    Integrating ergonomic knowledge into engineering design processes has been shown to contribute to healthy and effective designs of workplaces. However, it is also well-recognized that, in practice, ergonomists often have difficulties gaining access to and impacting engineering design processes...... employed in the same company, constituted a supporting factor for the possibilities to integrate ergonomic knowledge into the engineering design processes. However, the integration activities remained discrete and only happened in some of the design projects. A major barrier was related to the business...... to the ergonomic ambitions of the clients. The ergonomists’ ability to navigate, act strategically, and compromise on ergonomic inputs is also important in relation to having an impact in the engineering design processes. Familiarity with the engineering design terminology and the setup of design projects seems...

  19. Materials issues in silicon integrated circuit processing

    International Nuclear Information System (INIS)

    Wittmer, M.; Stimmell, J.; Strathman, M.

    1986-01-01

    The symposium on ''Materials Issues in Integrated Circuit Processing'' sought to bring together all of the materials issued pertinent to modern integrated circuit processing. The inherent properties of the materials are becoming an important concern in integrated circuit manufacturing and accordingly research in materials science is vital for the successful implementation of modern integrated circuit technology. The session on Silicon Materials Science revealed the advanced stage of knowledge which topics such as point defects, intrinsic and extrinsic gettering and diffusion kinetics have achieved. Adaption of this knowledge to specific integrated circuit processing technologies is beginning to be addressed. The session on Epitaxy included invited papers on epitaxial insulators and IR detectors. Heteroepitaxy on silicon is receiving great attention and the results presented in this session suggest that 3-d integrated structures are an increasingly realistic possibility. Progress in low temperature silicon epitaxy and epitaxy of thin films with abrupt interfaces was also reported. Diffusion and Ion Implantation were well presented. Regrowth of implant-damaged layers and the nature of the defects which remain after regrowth were discussed in no less than seven papers. Substantial progress was also reported in the understanding of amorphising boron implants and the use of gallium implants for the formation of shallow p/sup +/ -layers

  20. Pedagogic process modeling: Humanistic-integrative approach

    Directory of Open Access Journals (Sweden)

    Boritko Nikolaj M.

    2007-01-01

    Full Text Available The paper deals with some current problems of modeling the dynamics of the subject-features development of the individual. The term "process" is considered in the context of the humanistic-integrative approach, in which the principles of self education are regarded as criteria for efficient pedagogic activity. Four basic characteristics of the pedagogic process are pointed out: intentionality reflects logicality and regularity of the development of the process; discreteness (stageability in dicates qualitative stages through which the pedagogic phenomenon passes; nonlinearity explains the crisis character of pedagogic processes and reveals inner factors of self-development; situationality requires a selection of pedagogic conditions in accordance with the inner factors, which would enable steering the pedagogic process. Offered are two steps for singling out a particular stage and the algorithm for developing an integrative model for it. The suggested conclusions might be of use for further theoretic research, analyses of educational practices and for realistic predicting of pedagogical phenomena. .

  1. Carbon Nanotube Integration with a CMOS Process

    Science.gov (United States)

    Perez, Maximiliano S.; Lerner, Betiana; Resasco, Daniel E.; Pareja Obregon, Pablo D.; Julian, Pedro M.; Mandolesi, Pablo S.; Buffa, Fabian A.; Boselli, Alfredo; Lamagna, Alberto

    2010-01-01

    This work shows the integration of a sensor based on carbon nanotubes using CMOS technology. A chip sensor (CS) was designed and manufactured using a 0.30 μm CMOS process, leaving a free window on the passivation layer that allowed the deposition of SWCNTs over the electrodes. We successfully investigated with the CS the effect of humidity and temperature on the electrical transport properties of SWCNTs. The possibility of a large scale integration of SWCNTs with CMOS process opens a new route in the design of more efficient, low cost sensors with high reproducibility in their manufacture. PMID:22319330

  2. Process Integration Analysis of an Industrial Hydrogen Production Process

    OpenAIRE

    Stolten, Detlef; Grube, Thomas; Tock, Laurence; Maréchal, François; Metzger, Christian; Arpentinier, Philippe

    2010-01-01

    The energy efficiency of an industrial hydrogen production process using steam methane reforming (SMR) combined with the water gas shift reaction (WGS) is analyzed using process integration techniques based on heat cascade calculation and pinch analysis with the aim of identifying potential measures to enhance the process performance. The challenge is to satisfy the high temperature heat demand of the SMR reaction by minimizing the consumption of natural gas to feed the combustion and to expl...

  3. Maximum likelihood estimation for integrated diffusion processes

    DEFF Research Database (Denmark)

    Baltazar-Larios, Fernando; Sørensen, Michael

    We propose a method for obtaining maximum likelihood estimates of parameters in diffusion models when the data is a discrete time sample of the integral of the process, while no direct observations of the process itself are available. The data are, moreover, assumed to be contaminated...... EM-algorithm to obtain maximum likelihood estimates of the parameters in the diffusion model. As part of the algorithm, we use a recent simple method for approximate simulation of diffusion bridges. In simulation studies for the Ornstein-Uhlenbeck process and the CIR process the proposed method works...... by measurement errors. Integrated volatility is an example of this type of observations. Another example is ice-core data on oxygen isotopes used to investigate paleo-temperatures. The data can be viewed as incomplete observations of a model with a tractable likelihood function. Therefore we propose a simulated...

  4. Integration Process for the Habitat Demonstration Unit

    Science.gov (United States)

    Gill, Tracy; Merbitz, Jerad; Kennedy, Kriss; Tri, Terry; Howe, A. Scott

    2010-01-01

    The Habitat Demonstration Unit (HDU) is an experimental exploration habitat technology and architecture test platform designed for analog demonstration activities The HDU project has required a team to integrate a variety of contributions from NASA centers and outside collaborators and poses a challenge in integrating these disparate efforts into a cohesive architecture To complete the development of the HDU from conception in June 2009 to rollout for operations in July 2010, a cohesive integration strategy has been developed to integrate the various systems of HDU and the payloads, such as the Geology Lab, that those systems will support The utilization of interface design standards and uniquely tailored reviews have allowed for an accelerated design process Scheduled activities include early fit-checks and the utilization of a Habitat avionics test bed prior to equipment installation into HDU A coordinated effort to utilize modeling and simulation systems has aided in design and integration concept development Modeling tools have been effective in hardware systems layout, cable routing and length estimation, and human factors analysis Decision processes on the shell development including the assembly sequence and the transportation have been fleshed out early on HDU to maximize the efficiency of both integration and field operations Incremental test operations leading up to an integrated systems test allows for an orderly systems test program The HDU will begin its journey as an emulation of a Pressurized Excursion Module (PEM) for 2010 field testing and then may evolve to a Pressurized Core Module (PCM) for 2011 and later field tests, depending on agency architecture decisions The HDU deployment will vary slightly from current lunar architecture plans to include developmental hardware and software items and additional systems called opportunities for technology demonstration One of the HDU challenges has been designing to be prepared for the integration of

  5. Integrated biological, chemical and physical processes kinetic ...

    African Journals Online (AJOL)

    ... for C and N removal, only gas and liquid phase processes were considered for this integrated model. ... kLA value for the aeration system, which affects the pH in the anoxic and aerobic reactors through CO2 gas exchange. ... Water SA Vol.

  6. Integrating Leadership Processes: Redefining the Principles Course.

    Science.gov (United States)

    Neff, Bonita Dostal

    2002-01-01

    Revamps the principles of a public relations course, the first professional course in the public relations sequence, by integrating a leadership process and a service-learning component. Finds that more students are reflecting the interpersonal and team skills desired in the 1998 national study on public relations. (SG)

  7. The Integration Order of Vector Autoregressive Processes

    DEFF Research Database (Denmark)

    Franchi, Massimo

    We show that the order of integration of a vector autoregressive process is equal to the difference between the multiplicity of the unit root in the characteristic equation and the multiplicity of the unit root in the adjoint matrix polynomial. The equivalence with the standard I(1) and I(2...

  8. Process integration of organic Rankine cycle

    International Nuclear Information System (INIS)

    Desai, Nishith B.; Bandyopadhyay, Santanu

    2009-01-01

    An organic Rankine cycle (ORC) uses an organic fluid as a working medium within a Rankine cycle power plant. ORC offers advantages over conventional Rankine cycle with water as the working medium, as ORC generates shaft-work from low to medium temperature heat sources with higher thermodynamic efficiency. The dry and the isentropic fluids are most preferred working fluid for the ORC. The basic ORC can be modified by incorporating both regeneration and turbine bleeding to improve its thermal efficiency. In this paper, 16 different organic fluids have been analyzed as a working medium for the basic as well as modified ORCs. A methodology is also proposed for appropriate integration and optimization of an ORC as a cogeneration process with the background process to generate shaft-work. It has been illustrated that the choice of cycle configuration for appropriate integration with the background process depends on the heat rejection profile of the background process (i.e., the shape of the below pinch portion of the process grand composite curve). The benefits of integrating ORC with the background process and the applicability of the proposed methodology have been demonstrated through illustrative examples.

  9. Integrating ergonomics into the product development process

    DEFF Research Database (Denmark)

    Broberg, Ole

    1997-01-01

    and production engineers regarding information sources in problem solving, communication pattern, perception of ergonomics, motivation and requests to support tools and methods. These differences and the social and organizational contexts of the development process must be taken into account when considering......A cross-sectional case study was performed in a large company producing electro-mechanical products for industrial application. The purpose was to elucidate conditions and strategies for integrating ergonomics into the product development process thereby preventing ergonomic problems at the time...... of manufacture of new products. In reality the product development process is not a rational problem solving process and does not proceed in a sequential manner as decribed in engineering models. Instead it is a complex organizational process involving uncertainties, iterative elements and negotiation between...

  10. Stochastic processes in cell biology

    CERN Document Server

    Bressloff, Paul C

    2014-01-01

    This book develops the theory of continuous and discrete stochastic processes within the context of cell biology.  A wide range of biological topics are covered including normal and anomalous diffusion in complex cellular environments, stochastic ion channels and excitable systems, stochastic calcium signaling, molecular motors, intracellular transport, signal transduction, bacterial chemotaxis, robustness in gene networks, genetic switches and oscillators, cell polarization, polymerization, cellular length control, and branching processes. The book also provides a pedagogical introduction to the theory of stochastic process – Fokker Planck equations, stochastic differential equations, master equations and jump Markov processes, diffusion approximations and the system size expansion, first passage time problems, stochastic hybrid systems, reaction-diffusion equations, exclusion processes, WKB methods, martingales and branching processes, stochastic calculus, and numerical methods.   This text is primarily...

  11. Integrated Process Modeling-A Process Validation Life Cycle Companion.

    Science.gov (United States)

    Zahel, Thomas; Hauer, Stefan; Mueller, Eric M; Murphy, Patrick; Abad, Sandra; Vasilieva, Elena; Maurer, Daniel; Brocard, Cécile; Reinisch, Daniela; Sagmeister, Patrick; Herwig, Christoph

    2017-10-17

    During the regulatory requested process validation of pharmaceutical manufacturing processes, companies aim to identify, control, and continuously monitor process variation and its impact on critical quality attributes (CQAs) of the final product. It is difficult to directly connect the impact of single process parameters (PPs) to final product CQAs, especially in biopharmaceutical process development and production, where multiple unit operations are stacked together and interact with each other. Therefore, we want to present the application of Monte Carlo (MC) simulation using an integrated process model (IPM) that enables estimation of process capability even in early stages of process validation. Once the IPM is established, its capability in risk and criticality assessment is furthermore demonstrated. IPMs can be used to enable holistic production control strategies that take interactions of process parameters of multiple unit operations into account. Moreover, IPMs can be trained with development data, refined with qualification runs, and maintained with routine manufacturing data which underlines the lifecycle concept. These applications will be shown by means of a process characterization study recently conducted at a world-leading contract manufacturing organization (CMO). The new IPM methodology therefore allows anticipation of out of specification (OOS) events, identify critical process parameters, and take risk-based decisions on counteractions that increase process robustness and decrease the likelihood of OOS events.

  12. Terrestrial photovoltaic cell process testing

    Science.gov (United States)

    Burger, D. R.

    1985-01-01

    The paper examines critical test parameters, criteria for selecting appropriate tests, and the use of statistical controls and test patterns to enhance PV-cell process test results. The coverage of critical test parameters is evaluated by examining available test methods and then screening these methods by considering the ability to measure those critical parameters which are most affected by the generic process, the cost of the test equipment and test performance, and the feasibility for process testing.

  13. Audiovisual integration in speech perception: a multi-stage process

    DEFF Research Database (Denmark)

    Eskelund, Kasper; Tuomainen, Jyrki; Andersen, Tobias

    2011-01-01

    investigate whether the integration of auditory and visual speech observed in these two audiovisual integration effects are specific traits of speech perception. We further ask whether audiovisual integration is undertaken in a single processing stage or multiple processing stages....

  14. An integrated model for supplier selection process

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    In today's highly competitive manufacturing environment, the supplier selection process becomes one of crucial activities in supply chain management. In order to select the best supplier(s) it is not only necessary to continuously tracking and benchmarking performance of suppliers but also to make a tradeoff between tangible and intangible factors some of which may conflict. In this paper an integration of case-based reasoning (CBR), analytical network process (ANP) and linear programming (LP) is proposed to solve the supplier selection problem.

  15. The Efficient Separations and Processing Integrated Program

    International Nuclear Information System (INIS)

    Kuhn, W.L.; Gephart, J.M.

    1994-08-01

    The Efficient Separations and Processing Integrated Program (ESPIP) was created in 1991 to identify, develop, and perfect separations technologies and processes to treat wastes and address environmental problems throughout the US Department of Energy (DOE) complex. The ESPIP funds several multiyear tasks that address high-priority waste remediation problems involving high-level, low-level, transuranic, hazardous, and mixed (radioactive and hazardous) wastes. The ESPIP supports applied R ampersand D leading to demonstration or use of these separations technologies by other organizations within DOE's Office of Environmental Restoration and Waste Management. Examples of current ESPIP-funded separations technologies are described here

  16. Integrated system for automated financial document processing

    Science.gov (United States)

    Hassanein, Khaled S.; Wesolkowski, Slawo; Higgins, Ray; Crabtree, Ralph; Peng, Antai

    1997-02-01

    A system was developed that integrates intelligent document analysis with multiple character/numeral recognition engines in order to achieve high accuracy automated financial document processing. In this system, images are accepted in both their grayscale and binary formats. A document analysis module starts by extracting essential features from the document to help identify its type (e.g. personal check, business check, etc.). These features are also utilized to conduct a full analysis of the image to determine the location of interesting zones such as the courtesy amount and the legal amount. These fields are then made available to several recognition knowledge sources such as courtesy amount recognition engines and legal amount recognition engines through a blackboard architecture. This architecture allows all the available knowledge sources to contribute incrementally and opportunistically to the solution of the given recognition query. Performance results on a test set of machine printed business checks using the integrated system are also reported.

  17. Energy optimization of integrated process plants

    Energy Technology Data Exchange (ETDEWEB)

    Sandvig Nielsen, J

    1996-10-01

    A general approach for viewing the process synthesis as an evolutionary process is proposed. Each step is taken according to the present level of information and knowledge. This is formulated in a Process Synthesis Cycle. Initially the synthesis is conducted at a high abstraction level maximizing use of heuristics (prior experience, rules of thumbs etc). When further knowledge and information are available, heuristics will gradually be replaced by exact problem formulations. The principles in the Process Synthesis Cycle, is used to develop a general procedure for energy synthesis, based on available tools. The procedure is based on efficient use of process simulators with integrated Pinch capabilities (energy targeting). The proposed general procedure is tailored to three specific problems (Humid Air Turbine power plant synthesis, Nitric Acid process synthesis and Sulphuric Acid synthesis). Using the procedure reduces the problem dimension considerable and thus allows for faster evaluation of more alternatives. At more detailed level a new framework for the Heat Exchanger Network synthesis problem is proposed. The new framework is object oriented based on a general functional description of all elements potentially present in the heat exchanger network (streams, exchangers, pumps, furnaces etc.). (LN) 116 refs.

  18. Microwave plasmatrons for giant integrated circuit processing

    Energy Technology Data Exchange (ETDEWEB)

    Petrin, A.B.

    2000-02-01

    A method for calculating the interaction of a powerful microwave with a plane layer of magnetoactive low-pressure plasma under conditions of electron cyclotron resonance is presented. In this paper, the plasma layer is situated between a plane dielectric layer and a plane metal screen. The calculation model contains the microwave energy balance, particle balance, and electron energy balance. The equation that expressed microwave properties of nonuniform magnetoactive plasma is found. The numerical calculations of the microwave-plasma interaction for a one-dimensional model of the problem are considered. Applications of the results for microwave plasmatrons designed for processing giant integrated circuits are suggested.

  19. Parallel processing of structural integrity analysis codes

    International Nuclear Information System (INIS)

    Swami Prasad, P.; Dutta, B.K.; Kushwaha, H.S.

    1996-01-01

    Structural integrity analysis forms an important role in assessing and demonstrating the safety of nuclear reactor components. This analysis is performed using analytical tools such as Finite Element Method (FEM) with the help of digital computers. The complexity of the problems involved in nuclear engineering demands high speed computation facilities to obtain solutions in reasonable amount of time. Parallel processing systems such as ANUPAM provide an efficient platform for realising the high speed computation. The development and implementation of software on parallel processing systems is an interesting and challenging task. The data and algorithm structure of the codes plays an important role in exploiting the parallel processing system capabilities. Structural analysis codes based on FEM can be divided into two categories with respect to their implementation on parallel processing systems. The first category codes such as those used for harmonic analysis, mechanistic fuel performance codes need not require the parallelisation of individual modules of the codes. The second category of codes such as conventional FEM codes require parallelisation of individual modules. In this category, parallelisation of equation solution module poses major difficulties. Different solution schemes such as domain decomposition method (DDM), parallel active column solver and substructuring method are currently used on parallel processing systems. Two codes, FAIR and TABS belonging to each of these categories have been implemented on ANUPAM. The implementation details of these codes and the performance of different equation solvers are highlighted. (author). 5 refs., 12 figs., 1 tab

  20. An integrated approach for prioritized process improvement.

    Science.gov (United States)

    Vanteddu, Gangaraju; McAllister, Charles D

    2014-01-01

    The purpose of this paper is to propose an integrated framework to simultaneously identify and improve healthcare processes that are important from the healthcare provider's and patient's perspectives. A modified quality function deployment (QFD) chart is introduced to the field of healthcare quality assurance. A healthcare service example is used to demonstrate the utility of the proposed chart. The proposed framework is versatile and can be used in a wide variety of healthcare quality improvement contexts, wherein, two different perspectives are needed to be considered for identifying and improving critical healthcare processes. The modified QFD chart used in conjunction with the stacked Pareto chart will facilitate the identification of key performance metrics from the patient's and the hospital's perspectives. Subsequently, the chief contributory factors at different levels are identified in a very efficient manner. Healthcare quality improvement professionals will be able to use the proposed modified QFD chart in association with stacked Pareto chart for effective quality assurance.

  1. Globalization and Integration Processes in Europe

    Directory of Open Access Journals (Sweden)

    Beti Godnič

    2017-03-01

    Full Text Available Research Question (RQ: In the article we highlight the issue of whether Integration processes in the European Union are only a manifestation of these Globalization processes and if there are differences in the the old member States EU (15 and the new EU member states in changed micro and macro environment? Purpose: We wanted to determine how the old member States EU (15 and the new EU member states adapt to the new circumstances and other changes in the micro and macro environment. Method: Analysing complexity of the changes of the state of economic system, and complex fundamental global processes, which have been occurred in long period of time, need to supplement the pure scientific approach with other types of research work, more holistic approach, which is commonly used in Comparative economics. We have taken such an approach in this article. Results: In the article we studied the geopolitical changes in the micro and macro environment. We found that the development in the old EU member states EU-15 and in the new EU member states is different. EU havent addopted the harmonised economic policy which will solve the »North-South« problem and cross-state cultural consensus and find a way to operate systemically in global environment. Organization: The findings can be used to support undestanding of micro and macro envirnment of the companys and contribute for better strategic planning and design of the entire supply chain. Society: The findings can contribute to better understanding of integrative processes in the EU. Limitations/Future Research: The complexity of the problem and the dynamic changes in the functioning of the global market requires in-depth studiying of changes in the micro and macro environment of logistics companie

  2. Quality, Stability, and Safety Data of Packed Red Cells and Plasma Processed by Gravity Separation Using a New Fully Integrated Hollow-Fibre Filter Device

    Directory of Open Access Journals (Sweden)

    T. Brune

    2009-01-01

    Full Text Available Background. We developed a completely closed system based on gravity separation without centrifugation steps for separation of whole blood. With this new system we compared quality and stability of the processed blood components (PRC and plasma with respect to classical preparation. Furthermore the cost-effectiveness of this hollow fibre system was evaluated. Study Design and Methods. Whole blood collections of 15 regular blood donors were used for component preparation using the U shaped hollow fibre filter device. Results were compared to 15 whole blood preparations using centrifugation. The following parameters were evaluated: total hemoglobin, leukocyte counts, the serum concentration of total protein, lactate dehydrogenase (LDH and potassium. Furthermore ATIII, vWF and F VIII were analyzed at different timepoints. Results. packed red cells: the data directly after separation and after 42 days of storage are in line with the guidelines of the council of Europe. Plasma. all plasma quality data are in line with the guidelines of the council of Europe for quality assurance of plasma, except for a low protein amount (factor 0.75. Conclusion. Separation of whole blood on a clinical scale in this new closed system is feasible, however the plasma protein content must be optimized.

  3. Process-integrated slag treatment; Prozessintegrierte Schlackebehandlung

    Energy Technology Data Exchange (ETDEWEB)

    Koralewska, R.; Faulstich, M. [Technische Univ., Garching (Germany). Lehrstuhl fuer Wasserguete- und Abfallwirtschaft

    1998-09-01

    The present study compares two methods of washing waste incineration slag, one with water only, and one which uses additives during wet deslagging. The presented aggregate offers ideal conditions for process-integrated slag treatment. The paper gives a schematic description of the integrated slag washing process. The washing liquid serves to wash out the readily soluble constituents and remove the fines, while the additives are for immobilising heavy metals in the slag material. The study is based on laboratory and semi-technical trials on the wet chemical treatment of grate slag with addition of carbon dioxide and phosphoric acid. [Deutsch] Die dargestellten Untersuchungen beziehen sich auf den Vergleich zwischen einer Waesche der Muellverbrennungsschlacke mit Wasser und unter Zugabe von Additiven im Nassentschlacker. In diesem Aggregat bieten sich optimale Voraussetzungen fuer eine prozessintegrierte Schlackebehandlung. Die Durchfuehrung der integrierten Schlackewaesche wird schematisch gezeigt. Durch die Waschfluessigkeit sollen die leichtloeslichen Bestandteile ausgewaschen und die Feinanteile ausgetragen sowie durch die Additive zusaetzlich die Schwermetalle im Schlackematerial immobilisiert werden. Dazu erfolgten Labor- und halbtechnische Versuche zur nasschemischen Behandlung der Rostschlacken unter Zugabe von Kohlendioxid und Phosphorsaeure. (orig./SR)

  4. An Integrated Membrane Process for Butenes Production

    Directory of Open Access Journals (Sweden)

    Leonardo Melone

    2016-11-01

    Full Text Available Iso-butene is an important material for the production of chemicals and polymers. It can take part in various chemical reactions, such as hydrogenation, oxidation and other additions owing to the presence of a reactive double bond. It is usually obtained as a by-product of a petroleum refinery, by Fluidized Catalytic Cracking (FCC of naphtha or gas-oil. However, an interesting alternative to iso-butene production is n-butane dehydroisomerization, which allows the direct conversion of n-butane via dehydrogenation and successive isomerization. In this work, a simulation analysis of an integrated membrane system is proposed for the production and recovery of butenes. The dehydroisomerization of n-butane to iso-butene takes place in a membrane reactor where the hydrogen is removed from the reaction side with a Pd/Ag alloys membrane. Afterwards, the retentate and permeate post-processing is performed in membrane separation units for butenes concentration and recovery. Four different process schemes are developed. The performance of each membrane unit is analyzed by appropriately developed performance maps, to identify the operating conditions windows and the membrane permeation properties required to maximize the recovery of the iso-butene produced. An analysis of integrated systems showed a yield of butenes higher than the other reaction products with high butenes recovery in the gas separation section, with values of molar concentration between 75% and 80%.

  5. Manufacturing Process for OLED Integrated Substrate

    Energy Technology Data Exchange (ETDEWEB)

    Hung, Cheng-Hung [Vitro Flat Glass LLC, Cheswick, PA (United States). Glass Technology Center

    2017-03-31

    The main objective of this project was to develop a low-cost integrated substrate for rigid OLED solid-state lighting produced at a manufacturing scale. The integrated substrates could include combinations of soda lime glass substrate, light extraction layer, and an anode layer (i.e., Transparent Conductive Oxide, TCO). Over the 3+ year course of the project, the scope of work was revised to focus on the development of a glass substrates with an internal light extraction (IEL) layer. A manufacturing-scale float glass on-line particle embedding process capable of producing an IEL glass substrate having a thickness of less than 1.7mm and an area larger than 500mm x 400mm was demonstrated. Substrates measuring 470mm x 370mm were used in the OLED manufacturing process for fabricating OLED lighting panels in single pixel devices as large as 120.5mm x 120.5mm. The measured light extraction efficiency (calculated as external quantum efficiency, EQE) for on-line produced IEL samples (>50%) met the project’s initial goal.

  6. Integration of fuel cells into residential buildings

    International Nuclear Information System (INIS)

    Bell, J.M.; Entchev, E.; Gusdorf, J.; Szadkowski, F.; Swinton, M.; Kalbfleisch, W.; Marchand, R.

    2004-01-01

    Integration of small combined heat and power systems (CHP) into residential buildings is challenging as the loads are small, the load diversity is limited and there are a number of unresolved issues concerning sizing, control, peak loads, emergency operation, grid connection and export, etc. Natural Resources Canada has undertaken an initiative to investigate and develop techniques for the integration of small CHP systems into residential buildings using a highly instrumented house modified to allow quick installation and thorough monitoring of CHP integration techniques as well determining the performance of the CHP systems themselves when operating in a house. The first CHP system installed was a Stirling engine residential CHP system. It was used to examine the completeness of the CHP modifications to the house, to evaluate various building integration techniques and to measure the performance of the CHP system itself. The testing demonstrated the modified house to be an excellent facility for the development of CHP building integration techniques and the testing of residential CHP systems. The Stirling engine CHP system was found to operate well and produce meaningful input to the house. A second system (residential fuel cell) is presently being installed and building integration techniques and the performance of the fuel cell will be tested over the coming year. (author)

  7. International Political Processes of Integration of Education

    Directory of Open Access Journals (Sweden)

    Marina M. Lebedeva

    2017-09-01

    Full Text Available Introduction: the study of the international dimension of education is usually reduced to a comparative analysis of the characteristics of education in different countries. The situation began to change at the end of 20th – beginning of 21st centuries due to the rapid development of globalisation processes (the formation of a transparency of national borders and integration (deepening the cooperation between countries based on intergovernmental agreements. It had an impact on education, which was intensively internationalised (to acquire a wide international dimension. Despite the possible setbacks the process of internationalisation of education, the general vector of development is that this process will increase. The purpose of this article is to analyse what new challenges and opportunities are opened due to internationalisation of education (Russian education in particular. Materials and Methods: the study is based on the principles according to which education, on the one hand, depends on the transformation of the global political organisation of the world, on another hand – it is contributing to this transformation. Materials for the study are based on international agreements, which in particular are adopted in the framework of the Bologna process, and the results of scientific works of Russian and foreign scholars. Descriptive and comparative metho ds of analysis are widely used. Results: the analysis of the processes of internationalisation of education in the world has shown that, along with its traditional directions and aspects. It was noted that university begins to play a special role in the current world. It is shown that the specificity of education in Russia, which took shape due to a large terri¬tory and historical traditions, should be taken into account when forming a strategy for the development of the internationalisation of education in the country. Discussion and Conclusions: the specificity of Russia creates a risk

  8. Technology advancement for integrative stem cell analyses.

    Science.gov (United States)

    Jeong, Yoon; Choi, Jonghoon; Lee, Kwan Hyi

    2014-12-01

    Scientists have endeavored to use stem cells for a variety of applications ranging from basic science research to translational medicine. Population-based characterization of such stem cells, while providing an important foundation to further development, often disregard the heterogeneity inherent among individual constituents within a given population. The population-based analysis and characterization of stem cells and the problems associated with such a blanket approach only underscore the need for the development of new analytical technology. In this article, we review current stem cell analytical technologies, along with the advantages and disadvantages of each, followed by applications of these technologies in the field of stem cells. Furthermore, while recent advances in micro/nano technology have led to a growth in the stem cell analytical field, underlying architectural concepts allow only for a vertical analytical approach, in which different desirable parameters are obtained from multiple individual experiments and there are many technical challenges that limit vertically integrated analytical tools. Therefore, we propose--by introducing a concept of vertical and horizontal approach--that there is the need of adequate methods to the integration of information, such that multiple descriptive parameters from a stem cell can be obtained from a single experiment.

  9. The communication process in Telenursing: integrative review.

    Science.gov (United States)

    Barbosa, Ingrid de Almeida; Silva, Karen Cristina da Conceição Dias da; Silva, Vladimir Araújo da; Silva, Maria Júlia Paes da

    2016-01-01

    to identify scientific evidence about the communication process in Telenursing and analyze them. integrative review performed in March 2014. The search strategy, structured with the descriptors "telenursing" and "communication", was implemented in the databases Medline, Bireme, Cinahl, Scopus, Web of Science, Scielo, and Cochrane. ten studies were selected after inclusion and exclusion criteria. The main challenges were: the clinical condition of patients, the possibility for inadequate communication to cause misconduct, the absence of visual references in interactions without video, and difficulty understanding nonverbal communication. distance imposes communicative barriers in all elements: sender, recipient and message; and in both ways of transmission, verbal and nonverbal. The main difficulty is to understand nonverbal communication. To properly behave in this context, nurses must receive specific training to develop abilities and communication skills.

  10. Integrated Circuits for Analog Signal Processing

    CERN Document Server

    2013-01-01

      This book presents theory, design methods and novel applications for integrated circuits for analog signal processing.  The discussion covers a wide variety of active devices, active elements and amplifiers, working in voltage mode, current mode and mixed mode.  This includes voltage operational amplifiers, current operational amplifiers, operational transconductance amplifiers, operational transresistance amplifiers, current conveyors, current differencing transconductance amplifiers, etc.  Design methods and challenges posed by nanometer technology are discussed and applications described, including signal amplification, filtering, data acquisition systems such as neural recording, sensor conditioning such as biomedical implants, actuator conditioning, noise generators, oscillators, mixers, etc.   Presents analysis and synthesis methods to generate all circuit topologies from which the designer can select the best one for the desired application; Includes design guidelines for active devices/elements...

  11. Integrated Site Model Process Model Report

    International Nuclear Information System (INIS)

    Booth, T.

    2000-01-01

    The Integrated Site Model (ISM) provides a framework for discussing the geologic features and properties of Yucca Mountain, which is being evaluated as a potential site for a geologic repository for the disposal of nuclear waste. The ISM is important to the evaluation of the site because it provides 3-D portrayals of site geologic, rock property, and mineralogic characteristics and their spatial variabilities. The ISM is not a single discrete model; rather, it is a set of static representations that provide three-dimensional (3-D), computer representations of site geology, selected hydrologic and rock properties, and mineralogic-characteristics data. These representations are manifested in three separate model components of the ISM: the Geologic Framework Model (GFM), the Rock Properties Model (RPM), and the Mineralogic Model (MM). The GFM provides a representation of the 3-D stratigraphy and geologic structure. Based on the framework provided by the GFM, the RPM and MM provide spatial simulations of the rock and hydrologic properties, and mineralogy, respectively. Functional summaries of the component models and their respective output are provided in Section 1.4. Each of the component models of the ISM considers different specific aspects of the site geologic setting. Each model was developed using unique methodologies and inputs, and the determination of the modeled units for each of the components is dependent on the requirements of that component. Therefore, while the ISM represents the integration of the rock properties and mineralogy into a geologic framework, the discussion of ISM construction and results is most appropriately presented in terms of the three separate components. This Process Model Report (PMR) summarizes the individual component models of the ISM (the GFM, RPM, and MM) and describes how the three components are constructed and combined to form the ISM

  12. TWF process cell throughput study

    International Nuclear Information System (INIS)

    Fisher, D.L.

    1992-01-01

    The TWF will prepare transuranic (TRU) waste for permanent disposal at the Waste Isolation Pilot Plant (WIPP). WH ampersand MP's early participation in the TWF project included the installation and testing of a WPC mockup (using the conceptual design). Operating experience indicated significant improvements could be made in the WPC scheme, so we conducted a process cell equipment study with Equipment Engineering to identify better equipment and methods (ref. 4). The results of that study were used to construct the WPC computer simulation model

  13. Coal Integrated Gasification Fuel Cell System Study

    Energy Technology Data Exchange (ETDEWEB)

    Chellappa Balan; Debashis Dey; Sukru-Alper Eker; Max Peter; Pavel Sokolov; Greg Wotzak

    2004-01-31

    This study analyzes the performance and economics of power generation systems based on Solid Oxide Fuel Cell (SOFC) technology and fueled by gasified coal. System concepts that integrate a coal gasifier with a SOFC, a gas turbine, and a steam turbine were developed and analyzed for plant sizes in excess of 200 MW. Two alternative integration configurations were selected with projected system efficiency of over 53% on a HHV basis, or about 10 percentage points higher than that of the state-of-the-art Integrated Gasification Combined Cycle (IGCC) systems. The initial cost of both selected configurations was found to be comparable with the IGCC system costs at approximately $1700/kW. An absorption-based CO2 isolation scheme was developed, and its penalty on the system performance and cost was estimated to be less approximately 2.7% and $370/kW. Technology gaps and required engineering development efforts were identified and evaluated.

  14. Coal Integrated Gasification Fuel Cell System Study

    Energy Technology Data Exchange (ETDEWEB)

    Gregory Wotzak; Chellappa Balan; Faress Rahman; Nguyen Minh

    2003-08-01

    The pre-baseline configuration for an Integrated Gasification Fuel Cell (IGFC) system has been developed. This case uses current gasification, clean-up, gas turbine, and bottoming cycle technologies together with projected large planar Solid Oxide Fuel Cell (SOFC) technology. This pre-baseline case will be used as a basis for identifying the critical factors impacting system performance and the major technical challenges in implementing such systems. Top-level system requirements were used as the criteria to evaluate and down select alternative sub-systems. The top choice subsystems were subsequently integrated to form the pre-baseline case. The down-selected pre-baseline case includes a British Gas Lurgi (BGL) gasification and cleanup sub-system integrated with a GE Power Systems 6FA+e gas turbine and the Hybrid Power Generation Systems planar Solid Oxide Fuel Cell (SOFC) sub-system. The overall efficiency of this system is estimated to be 43.0%. The system efficiency of the pre-baseline system provides a benchmark level for further optimization efforts in this program.

  15. The integration of process monitoring for safeguards

    International Nuclear Information System (INIS)

    Cipiti, Benjamin B.; Zinaman, Owen R.

    2010-01-01

    The Separations and Safeguards Performance Model is a reprocessing plant model that has been developed for safeguards analyses of future plant designs. The model has been modified to integrate bulk process monitoring data with traditional plutonium inventory balances to evaluate potential advanced safeguards systems. Taking advantage of the wealth of operator data such as flow rates and mass balances of bulk material, the timeliness of detection of material loss was shown to improve considerably. Four diversion cases were tested including both abrupt and protracted diversions at early and late times in the run. The first three cases indicated alarms before half of a significant quantity of material was removed. The buildup of error over time prevented detection in the case of a protracted diversion late in the run. Some issues related to the alarm conditions and bias correction will need to be addressed in future work. This work both demonstrates the use of the model for performing diversion scenario analyses and for testing advanced safeguards system designs.

  16. Protecting genomic integrity in somatic cells and embryonic stem cells

    International Nuclear Information System (INIS)

    Hong, Y.; Cervantes, R.B.; Tichy, E.; Tischfield, J.A.; Stambrook, P.J.

    2007-01-01

    Mutation frequencies at some loci in mammalian somatic cells in vivo approach 10 -4 . The majority of these events occur as a consequence of loss of heterozygosity (LOH) due to mitotic recombination. Such high levels of DNA damage in somatic cells, which can accumulate with age, will cause injury and, after a latency period, may lead to somatic disease and ultimately death. This high level of DNA damage is untenable for germ cells, and by extrapolation for embryonic stem (ES) cells, that must recreate the organism. ES cells cannot tolerate such a high frequency of damage since mutations will immediately impact the altered cell, and subsequently the entire organism. Most importantly, the mutations may be passed on to future generations. ES cells, therefore, must have robust mechanisms to protect the integrity of their genomes. We have examined two such mechanisms. Firstly, we have shown that mutation frequencies and frequencies of mitotic recombination in ES cells are about 100-fold lower than in adult somatic cells or in isogenic mouse embryonic fibroblasts (MEFs). A second complementary protective mechanism eliminates those ES cells that have acquired a mutational burden, thereby maintaining a pristine population. Consistent with this hypothesis, ES cells lack a G1 checkpoint, and the two known signaling pathways that mediate the checkpoint are compromised. The checkpoint kinase, Chk2, which participates in both pathways is sequestered at centrosomes in ES cells and does not phosphorylate its substrates (i.e. p53 and Cdc25A) that must be modified to produce a G1 arrest. Ectopic expression of Chk2 does not rescue the p53-mediated pathway, but does restore the pathway mediated by Cdc25A. Wild type ES cells exposed to ionizing radiation do not accumulate in G1 but do so in S-phase and in G2. ES cells that ectopically express Chk2 undergo cell cycle arrest in G1 as well as G2, and appear to be protected from apoptosis

  17. Regulation of Cell Wall Biogenesis in Saccharomyces cerevisiae: The Cell Wall Integrity Signaling Pathway

    Science.gov (United States)

    Levin, David E.

    2011-01-01

    The yeast cell wall is a strong, but elastic, structure that is essential not only for the maintenance of cell shape and integrity, but also for progression through the cell cycle. During growth and morphogenesis, and in response to environmental challenges, the cell wall is remodeled in a highly regulated and polarized manner, a process that is principally under the control of the cell wall integrity (CWI) signaling pathway. This pathway transmits wall stress signals from the cell surface to the Rho1 GTPase, which mobilizes a physiologic response through a variety of effectors. Activation of CWI signaling regulates the production of various carbohydrate polymers of the cell wall, as well as their polarized delivery to the site of cell wall remodeling. This review article centers on CWI signaling in Saccharomyces cerevisiae through the cell cycle and in response to cell wall stress. The interface of this signaling pathway with other pathways that contribute to the maintenance of cell wall integrity is also discussed. PMID:22174182

  18. Integrating conceptualizations of experience into the interaction design process

    DEFF Research Database (Denmark)

    Dalsgaard, Peter

    2010-01-01

    From a design perspective, the increasing awareness of experiential aspects of interactive systems prompts the question of how conceptualizations of experience can inform and potentially be integrated into the interaction design process. This paper presents one approach to integrating theoretical...

  19. An integrated approach to process control

    NARCIS (Netherlands)

    Schippers, W.A.J.

    2001-01-01

    The control of production processes is the subject of several disciplines, such as statistical process control (SPC), total productive maintenance (TPM), and automated process control (APC). Although these disciplines are traditionally separated (both in science and in business practice), their

  20. Neuro-fuzzy Control of Integrating Processes

    Directory of Open Access Journals (Sweden)

    Anna Vasičkaninová

    2011-11-01

    Full Text Available Fuzzy technology is adaptive and easily applicable in different areas.Fuzzy logic provides powerful tools to capture the perceptionof natural phenomena. The paper deals with tuning of neuro-fuzzy controllers for integrating plant and for integrating plantswith time delay. The designed approach is verified on three examples by simulations and compared plants with classical PID control.Designed fuzzy controllers lead to better closed-loop control responses then classical PID controllers.

  1. Total Ore Processing Integration and Management

    Energy Technology Data Exchange (ETDEWEB)

    Leslie Gertsch

    2006-05-15

    This report outlines the technical progress achieved for project DE-FC26-03NT41785 (Total Ore Processing Integration and Management) during the period 01 January through 31 March of 2006. (1) Work in Progress: Minntac Mine--Graphical analysis of drill monitor data moved from two-dimensional horizontal patterns to vertical variations in measured and calculated parameters. The rock quality index and the two dimensionless ({pi}) indices developed by Kewen Yin of the University of Minnesota are used by Minntac Mine to design their blasts, but the drill monitor data from any given pattern is obviously not available for the design of that shot. Therefore, the blast results--which are difficult to quantify in a short time--must be back-analyzed for comparison with the drill monitor data to be useful for subsequent blast designs. {pi}{sub 1} indicates the performance of the drill, while {pi}{sub 2} is a measure of the rock resistance to drilling. As would be expected, since a drill tends to perform better in rock that offers little resistance, {pi}{sub 1} and {pi}{sub 2} are strongly inversely correlated; the relationship is a power function rather than simply linear. Low values of each Pi index tend to be quantized, indicating that these two parameters may be most useful above certain minimum magnitudes. (2) Work in Progress: Hibtac Mine--Statistical examination of a data set from Hibtac Mine (Table 1) shows that incorporating information on the size distribution of material feeding from the crusher to the autogenous mills improves the predictive capability of the model somewhat (43% vs. 44% correlation coefficient), but a more important component is production data from preceding days (26% vs. 44% correlation coefficient), determined using exponentially weighted moving average predictive variables. This lag effect likely reflects the long and varied residence times of the different size fragments in the grinding mills. The rock sizes are also correlated with the geologic

  2. Structural integration of separation and reaction systems: I. Integration of stage-wise processes

    Directory of Open Access Journals (Sweden)

    Mitrović Milan

    2002-01-01

    Full Text Available The structural integration of separation processes, using multifunctional equipment, has been studied on four stage-wise liquid-liquid separations extraction, absorption, distillation, adsorption and on some combinations of these processes. It was shown for stage - wise processes that the ultimate aim of equipment integration is 3-way integration (by components by steps and by stages and that membrane multiphase contactors present concerning the equipment optimal solutions in many cases. First, by using partially integrated equipment and, later by developing fully integrated systems it was experimentally confirmed that structural 3-way integration produces much higher degrees of component separations and component enrichments in compact and safe equipment.

  3. Enzymatic cell disruption of microalgae biomass in biorefinery processes.

    Science.gov (United States)

    Demuez, Marie; Mahdy, Ahmed; Tomás-Pejó, Elia; González-Fernández, Cristina; Ballesteros, Mercedes

    2015-10-01

    When employing biotechnological processes for the procurement of biofuels and bio-products from microalgae, one of the most critical steps affecting economy and yields is the "cell disruption" stage. Currently, enzymatic cell disruption has delivered effective and cost competitive results when compared to mechanical and chemical cell disruption methods. However, the introduction of enzymes implies additional associated cost within the overall process. In order to reduce this cost, autolysis of microalgae is proposed as alternative enzymatic cell disruption method. This review aims to provide the state of the art of enzymatic cell disruption treatments employed in biorefinery processes and highlights the use of endopeptidases. During the enzymatic processes of microalgae life cycle, some lytic enzymes involved in cell division and programmed cell death have been proven useful in performing cell lysis. In this context, the role of endopeptidases is emphasized. Mirroring these natural events, an alternative cell disruption approach is proposed and described with the potential to induce the autolysis process using intrinsic cell enzymes. Integrating induced autolysis within biofuel production processes offers a promising approach to reduce overall global costs and energetic input associated with those of current cell disruption methods. A number of options for further inquiry are also discussed. © 2015 Wiley Periodicals, Inc.

  4. Integrated Intelligent Modeling, Design and Control of Crystal Growth Processes

    National Research Council Canada - National Science Library

    Prasad, V

    2000-01-01

    .... This MURI program took an integrated approach towards modeling, design and control of crystal growth processes and in conjunction with growth and characterization experiments developed much better...

  5. Integrated pillar scatterers for speeding up classification of cell holograms.

    Science.gov (United States)

    Lugnan, Alessio; Dambre, Joni; Bienstman, Peter

    2017-11-27

    The computational power required to classify cell holograms is a major limit to the throughput of label-free cell sorting based on digital holographic microscopy. In this work, a simple integrated photonic stage comprising a collection of silica pillar scatterers is proposed as an effective nonlinear mixing interface between the light scattered by a cell and an image sensor. The light processing provided by the photonic stage allows for the use of a simple linear classifier implemented in the electric domain and applied on a limited number of pixels. A proof-of-concept of the presented machine learning technique, which is based on the extreme learning machine (ELM) paradigm, is provided by the classification results on samples generated by 2D FDTD simulations of cells in a microfluidic channel.

  6. A vertically integrated capacitorless memory cell

    International Nuclear Information System (INIS)

    Tong Xiaodong; Wu Hao; Zhao Lichuan; Wang Ming; Zhong Huicai

    2013-01-01

    A two-port capacitorless PNPN device with high density, high speed and low power memory fabricated using standard CMOS technology is presented. Experiments and calibrated simulations were conducted which prove that this new memory cell has a high operation speed (ns level), large read current margin (read current ratio of 10 4 ×), low process variation, good thermal reliability and available retention time (190 ms). Furthermore, the new memory cell is free of the cyclic endurance/reliability problems induced by hot-carrier injection due to the gateless structure. (semiconductor devices)

  7. Sensor integration for robotic laser welding processes

    NARCIS (Netherlands)

    Iakovou, D.; Aarts, Ronald G.K.M.; Meijer, J.; Ostendorf, A; Hoult, A.; Lu, Y.

    2005-01-01

    The use of robotic laser welding is increasing among industrial applications, because of its ability to weld objects in three dimensions. Robotic laser welding involves three sub-processes: seam detection and tracking, welding process control, and weld seam inspection. Usually, for each sub-process,

  8. Integrating the autonomous subsystems management process

    Science.gov (United States)

    Ashworth, Barry R.

    1992-01-01

    Ways in which the ranking of the Space Station Module Power Management and Distribution testbed may be achieved and an individual subsystem's internal priorities may be managed within the complete system are examined. The application of these results in the integration and performance leveling of the autonomously managed system is discussed.

  9. Integrating personality structure, personality process, and personality development

    NARCIS (Netherlands)

    Baumert, Anna; Schmitt, Manfred; Perugini, Marco; Johnson, Wendy; Blum, Gabriela; Borkenau, Peter; Costantini, Giulio; Denissen, J.J.A.; Fleeson, William; Grafton, Ben; Jayawickreme, Eranda; Kurzius, Elena; MacLeod, Colin; Miller, Lynn C.; Read, Stephen J.; Robinson, Michael D.; Wood, Dustin; Wrzus, Cornelia

    2017-01-01

    In this target article, we argue that personality processes, personality structure, and personality development have to be understood and investigated in integrated ways in order to provide comprehensive responses to the key questions of personality psychology. The psychological processes and

  10. Process Variations and Probabilistic Integrated Circuit Design

    CERN Document Server

    Haase, Joachim

    2012-01-01

    Uncertainty in key parameters within a chip and between different chips in the deep sub micron era plays a more and more important role. As a result, manufacturing process spreads need to be considered during the design process.  Quantitative methodology is needed to ensure faultless functionality, despite existing process variations within given bounds, during product development.   This book presents the technological, physical, and mathematical fundamentals for a design paradigm shift, from a deterministic process to a probability-orientated design process for microelectronic circuits.  Readers will learn to evaluate the different sources of variations in the design flow in order to establish different design variants, while applying appropriate methods and tools to evaluate and optimize their design.  Trains IC designers to recognize problems caused by parameter variations during manufacturing and to choose the best methods available to mitigate these issues during the design process; Offers both qual...

  11. Integrating interface slicing into software engineering processes

    Science.gov (United States)

    Beck, Jon

    1993-01-01

    Interface slicing is a tool which was developed to facilitate software engineering. As previously presented, it was described in terms of its techniques and mechanisms. The integration of interface slicing into specific software engineering activities is considered by discussing a number of potential applications of interface slicing. The applications discussed specifically address the problems, issues, or concerns raised in a previous project. Because a complete interface slicer is still under development, these applications must be phrased in future tenses. Nonetheless, the interface slicing techniques which were presented can be implemented using current compiler and static analysis technology. Whether implemented as a standalone tool or as a module in an integrated development or reverse engineering environment, they require analysis no more complex than that required for current system development environments. By contrast, conventional slicing is a methodology which, while showing much promise and intuitive appeal, has yet to be fully implemented in a production language environment despite 12 years of development.

  12. Silicon wafers for integrated circuit process

    OpenAIRE

    Leroy , B.

    1986-01-01

    Silicon as a substrate material will continue to dominate the market of integrated circuits for many years. We first review how crystal pulling procedures impact the quality of silicon. We then investigate how thermal treatments affect the behaviour of oxygen and carbon, and how, as a result, the quality of silicon wafers evolves. Gettering techniques are then presented. We conclude by detailing the requirements that wafers must satisfy at the incoming inspection.

  13. Introduction: Integration as a three-way process approach?

    NARCIS (Netherlands)

    Garcés-Mascareñas, B.; Penninx, R.; Garcés-Mascareñas, B.; Penninx, R.

    2016-01-01

    This chapter introduces the topic of this volume, which is the recent departure from viewing integration as a strictly two-way process (between migrants and the receiving society) to acknowledge the potential role that countries of origin might play in support of the integration process. It traces

  14. EPR design tools. Integrated data processing tools

    International Nuclear Information System (INIS)

    Kern, R.

    1997-01-01

    In all technical areas, planning and design have been supported by electronic data processing for many years. New data processing tools had to be developed for the European Pressurized Water Reactor (EPR). The work to be performed was split between KWU and Framatome and laid down in the Basic Design contract. The entire plant was reduced to a logical data structure; the circuit diagrams and flowsheets of the systems were drafted, the central data pool was established, the outlines of building structures were defined, the layout of plant components was planned, and the electrical systems were documented. Also building construction engineering was supported by data processing. The tasks laid down in the Basic Design were completed as so-called milestones. Additional data processing tools also based on the central data pool are required for the phases following after the Basic Design phase, i.e Basic Design Optimization; Detailed Design; Management; Construction, and Commissioning. (orig.) [de

  15. Radiation damage to integrated injection logic cells

    International Nuclear Information System (INIS)

    Pease, R.L.; Galloway, K.F.; Stehlin, R.A.

    1975-01-01

    The effects of neutron and total dose gamma irradiations on the electrical characteristics of an integrated injection logic (l 2 L) cell and an l 2 L multiple inverter circuit were investigated. These units were designed and fabricated to obtain circuit development information and did not have radiation hardness as a goal. The following parameters of the test structures were measured as a function of total dose and neutron fluence: the dc common-base current gain of the lateral pnp transistor; the dc common-emitter current gain of the vertical npn transistor; the forward current-voltage characteristics of the injector-substrate junction, and the propagation delay versus power dissipation per gate for the multiple inverter circuit. The limitations of the present test structures in a radiation environment and possible hardening techniques are discussed

  16. Fuel Cell Development and Test Laboratory | Energy Systems Integration

    Science.gov (United States)

    Facility | NREL Fuel Cell Development and Test Laboratory Fuel Cell Development and Test Laboratory The Energy System Integration Facility's Fuel Cell Development and Test Laboratory supports fuel cell research and development projects through in-situ fuel cell testing. Photo of a researcher running

  17. Integration of air quality-related planning processes : report

    International Nuclear Information System (INIS)

    2004-05-01

    Several communities in British Columbia have conducted air quality, greenhouse gas, or community energy management plans. This report explored the possibility of integrating 3 community-based air quality-related planning processes into a single process and evaluated the use of these 3 processes by local governments and First Nations in identifying and addressing air quality-related objectives, and determined to what extent they could be integrated to achieve planning objectives for air quality, greenhouse gas emissions, and energy supply and conservation. The lessons learned from 9 case studies in British Columbia were presented. The purpose of the case studies was to examine how communities handled emissions and energy related inventory and planning work, as well as their experiences with, or considerations for, an integrated process. The lessons were grouped under several key themes including organization and stakeholder involvement; messaging and focus; leadership/champions; and resources and capacity. The report also outlined a framework for an integrated planning process and provided recommendations regarding how an integrated or complementary process could be performed. A number of next steps were also offered for the provincial government to move the concept of an integrated process forward with the assistance of other partners. These included identifying the resources required to support communities engaging in an integrated process as well as discussing the series of options for provincial support with key stakeholders. refs., tabs., figs

  18. Integrating human factors into process hazard analysis

    International Nuclear Information System (INIS)

    Kariuki, S.G.; Loewe, K.

    2007-01-01

    A comprehensive process hazard analysis (PHA) needs to address human factors. This paper describes an approach that systematically identifies human error in process design and the human factors that influence its production and propagation. It is deductive in nature and therefore considers human error as a top event. The combinations of different factors that may lead to this top event are analysed. It is qualitative in nature and is used in combination with other PHA methods. The method has an advantage because it does not look at the operator error as the sole contributor to the human failure within a system but a combination of all underlying factors

  19. Decoding Signal Processing at the Single-Cell Level

    Energy Technology Data Exchange (ETDEWEB)

    Wiley, H. Steven

    2017-12-01

    The ability of cells to detect and decode information about their extracellular environment is critical to generating an appropriate response. In multicellular organisms, cells must decode dozens of signals from their neighbors and extracellular matrix to maintain tissue homeostasis while still responding to environmental stressors. How cells detect and process information from their surroundings through a surprisingly limited number of signal transduction pathways is one of the most important question in biology. Despite many decades of research, many of the fundamental principles that underlie cell signal processing remain obscure. However, in this issue of Cell Systems, Gillies et al present compelling evidence that the early response gene circuit can act as a linear signal integrator, thus providing significant insight into how cells handle fluctuating signals and noise in their environment.

  20. Integrated modelling of near field and engineered barrier system processes

    International Nuclear Information System (INIS)

    Lamont, A.; Gansemer, J.

    1994-01-01

    The Yucca Mountain Integrating Model (YMIM) is an integrated model of the Engineered barrier System has been developed to assist project managers at LLNL in identifying areas where research emphasis should be placed. The model was designed to be highly modular so that a model of an individual process could be easily modified or replaced without interfering with the models of other processes. The modules modelling container failure and the dissolution of nuclides include particularly detailed, temperature dependent models of their corresponding processes

  1. Value Creation through ICT Integration in Merger & Acquisition Processes

    DEFF Research Database (Denmark)

    Holm Larsen, Michael

    2005-01-01

    As deals are becoming more complex, and as technology, and the people supporting it, are becoming key drivers of merger and acquisition processes, planning of information and communication technologies in early stages of the integration process is vital to the realization of benefits of an Merger...... & Acquisition process. This statement is substantiated through review of literature from academics as well as practitioners, and case exemplifications of the financial service organization, the Nordea Group. Keywords: ICT Integration, Mergers & Acquisitions, Nordea Group....

  2. Ergonomics Integration Omproving Production Process Management in Enterprises of Latvia

    OpenAIRE

    Henrijs Kaļķis

    2013-01-01

    Dotoral thesis ERGONOMICS INTEGRATION IMPROVING PRODUCTION PROCESS MANAGEMENT IN ENTERPRISES OF LATVIA ANNOTATION Ergonomics integration in process management has great significance in organisations` growth of productivity. It is a new approach to entrepreneurship and business strategy, where ergonomic aspects and values are taken into account in ensuring the effective process management and profitability of enterprises. This study is aimed at solution of the problem of e...

  3. The integrity management cycle as a business process

    Energy Technology Data Exchange (ETDEWEB)

    Ackhurst, Trent B.; Peverelli, Romina P. [PIMS - Pipeline Integrity Management Specialists of London Ltd. (United Kingdom).

    2009-07-01

    It is a best-practice Oil and Gas pipeline integrity and reliability technique to apply integrity management cycles. This is conforms to the business principles of continuous improvement. This paper examines the integrity management cycle - both goals and objectives and subsequent component steps - from a business perspective. Traits that businesses require, to glean maximum benefit from such a cycle, are highlighted. A case study focuses upon an integrity and reliability process developed to apply to pipeline operators. installations. This is compared and contrasted to the pipeline integrity management cycle to underline both cycles. consistency with the principles of continuous improvement. (author)

  4. Preparing Health Care Processes for IT Integration

    DEFF Research Database (Denmark)

    Walley, Paul; Laursen, Martin Lindgård

    2005-01-01

    effectiveness and efficiency of the system. Using data from two countries and involving 200 hospitals, the paper addresses the current state of determinacy of processes and explores the potential route towards standardisation. We hypothesise that management paradigms such as “lean thinking...

  5. Sensegiving and sensemaking in integration processes

    DEFF Research Database (Denmark)

    Søderberg, Anne-Marie

    2003-01-01

    at different hierarchical levels, interviewed at different points of timeover a period of six years. The collected narrative interviews are viewed as retrospectiveinterpretations of change processes in the acquired company, made by organizational actorsas parts of the plots they are continually constructing...

  6. Risk analysis of hematopoietic stem cell transplant process: failure mode, effect, and criticality analysis and hazard analysis critical control point methods integration based on guidelines to good manufacturing practice for medicinal product ANNEX 20 (February 2008).

    Science.gov (United States)

    Gianassi, S; Bisin, S; Bindi, B; Spitaleri, I; Bambi, F

    2010-01-01

    The collection and handling of hematopoietic stem cells (HSCs) must meet high quality requirements. An integrated Quality Risk Management can help to identify and contain potential risks related to HSC production. Risk analysis techniques allow one to "weigh" identified hazards, considering the seriousness of their effects, frequency, and detectability, seeking to prevent the most harmful hazards. The Hazard Analysis Critical Point, recognized as the most appropriate technique to identify risks associated with physical, chemical, and biological hazards for cellular products, consists of classifying finished product specifications and limits of acceptability, identifying all off-specifications, defining activities that can cause them, and finally establishing both a monitoring system for each Critical Control Point and corrective actions for deviations. The severity of possible effects on patients, as well as the occurrence and detectability of critical parameters, are measured on quantitative scales (Risk Priority Number [RPN]). Risk analysis was performed with this technique on manipulation process of HPC performed at our blood center. The data analysis showed that hazards with higher values of RPN with greater impact on the process are loss of dose and tracking; technical skills of operators and manual transcription of data were the most critical parameters. Problems related to operator skills are handled by defining targeted training programs, while other critical parameters can be mitigated with the use of continuous control systems. The blood center management software was completed by a labeling system with forms designed to be in compliance with standards in force and by starting implementation of a cryopreservation management module. Copyright 2010 Elsevier Inc. All rights reserved.

  7. Integrating Porous Resins In Enzymatic Processes

    DEFF Research Database (Denmark)

    Al-Haque, Naweed

    . Screening resins for moderately hydrophobic multi-component systems is challenging. Often it is found that the capacity of the resin is inversely related with product selectivity. Therefore a tradeoff has to be made between these parameters which can be crucial from an economic point of view. A low resin...... procedure. The screening therefore becomes a multi-objective task that has to be solved simultaneously. Such an approach has been applied in the method formulated in this framework. To overcome these challenges, different process strategies are required to obtain high yields. A number of different...... inhibition, has gained considerable recognition. The resins act as a reservoir for the inhibitory substrate and a sink for the inhibitory product and simultaneously attain the required high substrate loading to make the process economically feasible. In this way the potential benefit of the enzyme can...

  8. Inverted process for graphene integrated circuits fabrication.

    Science.gov (United States)

    Lv, Hongming; Wu, Huaqiang; Liu, Jinbiao; Huang, Can; Li, Junfeng; Yu, Jiahan; Niu, Jiebin; Xu, Qiuxia; Yu, Zhiping; Qian, He

    2014-06-07

    CMOS compatible 200 mm two-layer-routing technology is employed to fabricate graphene field-effect transistors (GFETs) and monolithic graphene ICs. The process is inverse to traditional Si technology. Passive elements are fabricated in the first metal layer and GFETs are formed with buried gate/source/drain in the second metal layer. Gate dielectric of 3.1 nm in equivalent oxide thickness (EOT) is employed. 500 nm-gate-length GFETs feature a yield of 80% and fT/fmax = 17 GHz/15.2 GHz RF performance. A high-performance monolithic graphene frequency multiplier is demonstrated using the proposed process. Functionality was demonstrated up to 8 GHz input and 16 GHz output. The frequency multiplier features a 3 dB bandwidth of 4 GHz and conversion gain of -26 dB.

  9. Formalism of continual integrals for cascade processes with particle fusion

    International Nuclear Information System (INIS)

    Gedalin, Eh.V.

    1987-01-01

    Formalism of continuous integrals for description of cascade processes, in which besides cascade particle reproduction, their synthesis and coalescence take place, is used. Account of cascade particle coalescence leads to the fact that the development of some cascade branches cannot be independent and main equations of the cascade process become functional instead of integral. The method of continuous intagrals permits to construct in the closed form producing functionals for the cascade process and to obtain the rules of their calculation using diagrams. Analytical expressions in the form of continuous integrals for producing functionals describing cascade development are obtained

  10. Systems integration processes for space nuclear electric propulsion systems

    International Nuclear Information System (INIS)

    Olsen, C.S.; Rice, J.W.; Stanley, M.L.

    1991-01-01

    The various components and subsystems that comprise a nuclear electric propulsion system should be developed and integrated so that each functions ideally and so that each is properly integrated with the other components and subsystems in the optimum way. This paper discusses how processes similar to those used in the development and intergration of the subsystems that comprise the Multimegawatt Space Nuclear Power System concepts can be and are being efficiently and effectively utilized for these purposes. The processes discussed include the development of functional and operational requirements at the system and subsystem level; the assessment of individual nuclear power supply and thruster concepts and their associated technologies; the conduct of systems integration efforts including the evaluation of the mission benefits for each system; the identification and resolution of concepts development, technology development, and systems integration feasibility issues; subsystem, system, and technology development and integration; and ground and flight subsystem and integrated system testing

  11. METHODOLOGY FRAMEWORK FOR PROCESS INTEGRATION AND SERVICE MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Darko Galinec

    2007-06-01

    Full Text Available History of information systems development was driven by business system's functions automation and mergers and acquisitions - business subjects integration into a whole. Modern business requires business processes integration through their dynamics and thus enterprise application integration (EAI as well. In this connection it is necessary to find ways and means of application integration and interaction in a consistent and reliable way. The real-time enterprise (RTE monitors, captures and analyzes root causes and overt events that are critical to its success the instant those events occur [6]. EAI is determined by business needs and business requirements. It must be based on business process repository and models, business integration methodology (BIM and information flow as well. Decisions concerning technology must be in function of successful application integration. In this paper EAI methodological framework and technological concepts for its achievements are introduced.

  12. Improving Construction Process through Integration and Concurrent Engineering

    Directory of Open Access Journals (Sweden)

    Malik Khalfan

    2012-11-01

    Full Text Available In an increasingly competitive business environment, improvedtime-to-market, reduced production cost, quality of the productand customer involvement are rapidly becoming the key successfactors for any product development process. Consequently, mostorganisations are moving towards the adoption of latest technologyand new management concepts and philosophies such as totalquality management and concurrent engineering (CE to bringimprovement in their product development process. This paperdiscusses the adoption of integrated processes and CE withinthe construction industry to enable construction organisations toimprove their project development process. It also discusses aproposed integrated database model for the construction projects,which should enable the construction process to improve, becomemore effective and more efficient.

  13. Integrated Process Design, Control and Analysis of Intensified Chemical Processes

    DEFF Research Database (Denmark)

    Mansouri, Seyed Soheil

    chemical processes; for example, intensified processes such as reactive distillation. Most importantly, it identifies and eliminates potentially promising design alternatives that may have controllability problems later. To date, a number of methodologies have been proposed and applied on various problems......, that the same principles that apply to a binary non-reactive compound system are valid also for a binary-element or a multi-element system. Therefore, it is advantageous to employ the element based method for multicomponent reaction-separation systems. It is shown that the same design-control principles...

  14. Integrating risk management into the baselining process

    International Nuclear Information System (INIS)

    Jennett, N.; Tonkinson, A.

    1994-01-01

    These processes work together in building the project (comprised of the technical, schedule, and cost baselines) against which performance is measured and changes to the scope, schedule and cost of a project are managed and controlled. Risk analysis is often performed as the final element of the scheduling or estimating processes, a precursor to establishing cost and schedule contingency. However, best business practices dictate that information that may be crucial to the success of a project be analyzed and incorporated into project planning as soon as it is available and usable. The purpose or risk management is not to eliminate risk. Neither is it intended to suggest wholesale re-estimating and re-scheduling of a project. Rather, the intent is to make provisions to reduce and control the schedule and/or cost ramifications of risk by anticipating events and conditions that cannot be reliably planned for and which have the potential to negatively impact accomplishment of the technical objectives and requirements of the project

  15. Psychological needs and the facilitation of integrative processes.

    Science.gov (United States)

    Ryan, R M

    1995-09-01

    The assumption that there are innate integrative or actualizing tendencies underlying personality and social development is reexamined. Rather than viewing such processes as either nonexistent or as automatic, I argue that they are dynamic and dependent upon social-contextual supports pertaining to basic human psychological needs. To develop this viewpoint, I conceptually link the notion of integrative tendencies to specific developmental processes, namely intrinsic motivation; internalization; and emotional integration. These processes are then shown to be facilitated by conditions that fulfill psychological needs for autonomy, competence, and relatedness, and forestalled within contexts that frustrate these needs. Interactions between psychological needs and contextual supports account, in part, for the domain and situational specificity of motivation, experience, and relative integration. The meaning of psychological needs (vs. wants) is directly considered, as are the relations between concepts of integration and autonomy and those of independence, individualism, efficacy, and cognitive models of "multiple selves."

  16. CMOS and BiCMOS process integration and device characterization

    CERN Document Server

    El-Kareh, Badih

    2009-01-01

    Covers both the theoretical and practical aspects of modern silicon devices and the relationship between their electrical properties and processing conditions. This book also covers silicon devices and integrated process technologies. It discusses modern silicon devices, their characteristics, and interactions with process parameters.

  17. Integrating Scientific Array Processing into Standard SQL

    Science.gov (United States)

    Misev, Dimitar; Bachhuber, Johannes; Baumann, Peter

    2014-05-01

    We live in a time that is dominated by data. Data storage is cheap and more applications than ever accrue vast amounts of data. Storing the emerging multidimensional data sets efficiently, however, and allowing them to be queried by their inherent structure, is a challenge many databases have to face today. Despite the fact that multidimensional array data is almost always linked to additional, non-array information, array databases have mostly developed separately from relational systems, resulting in a disparity between the two database categories. The current SQL standard and SQL DBMS supports arrays - and in an extension also multidimensional arrays - but does so in a very rudimentary and inefficient way. This poster demonstrates the practicality of an SQL extension for array processing, implemented in a proof-of-concept multi-faceted system that manages a federation of array and relational database systems, providing transparent, efficient and scalable access to the heterogeneous data in them.

  18. Integrated Dialogue System for Spatial Decision Process

    International Nuclear Information System (INIS)

    Nishiyama, Yumi; Fukui, Hiromichi; Kaneyasu, Iwao; Nagasaka, Toshinari; Usuda, Yuichiro; Sakamoto, Ai; Kusafuka, Minako

    2003-01-01

    The disposal of high-level radioactive waste (HLW) is a difficult challenge for all countries that uses nuclear energy. In Japan, an implementing agency for HLW was authorized in 2001, and now seeking for municipalities that voluntarily apply to be a preliminary investigation area for a final disposal site. Along with these policy progresses, the HLW disposal program has been gaining social attentions. This leads to high demand for a systematic process for evaluating the proposed policy and environmental impact of geological disposal so that policy decisions can adequately address technical, ethical, and social considerations. As a step toward this objective, we have developed a participatory decision support system on the web. Web-based communication is in its infancy but may be viable support tool to engage different people. Through the study, we aimed to examine the possibility of web-based dialogue system for spatial decision process. One conclusion from the web-based dialogue is that it is possible to create a working environment on the web within those who have different backgrounds and interests. From the results, we found many findings that should be taken into account for further development. One is the need to re-construct the data, model imagery and opinions to judge the problem objectively. We will reexamine the contents based on the international activities so that participants can understand what the information means in the context. Facilitation is key element on the web, also. He or she is expected to make the atmosphere where even those who don't have high-level knowledge can participate in and arouse their opinion from the faceless communication. In the point, the auto navigation comes in very useful

  19. 49 CFR 1106.4 - The Safety Integration Plan process.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false The Safety Integration Plan process. 1106.4 Section 1106.4 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... CONSIDERATION OF SAFETY INTEGRATION PLANS IN CASES INVOLVING RAILROAD CONSOLIDATIONS, MERGERS, AND ACQUISITIONS...

  20. Integrating Islamist Militants into the Political Process : Palestinian ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Integrating Islamist Militants into the Political Process : Palestinian Hamas. The striking victory of Hamas in the elections of January 2006 raises questions about the integration of Islamists into the Palestinian political system. This project, which is part of a larger program of research on the role of political parties in the Middle ...

  1. Integration mockup and process material management system

    Science.gov (United States)

    Verble, Adas James, Jr.

    1992-01-01

    Work to define and develop a full scale Space Station Freedom (SSF) mockup with the flexibility to evolve into future designs, to validate techniques for maintenance and logistics and verify human task allocations and support trade studies is described. This work began in early 1985 and ended in August, 1991. The mockups are presently being used at MSFC in Building 4755 as a technology and design testbed, as well as for public display. Micro Craft also began work on the Process Material Management System (PMMS) under this contract. The PMMS simulator was a sealed enclosure for testing to identify liquids, gaseous, particulate samples, and specimen including, urine, waste water, condensate, hazardous gases, surrogate gasses, liquids, and solids. The SSF would require many trade studies to validate techniques for maintenance and logistics and verify system task allocations; it was necessary to develop a full scale mockup which would be representative of current SSF design with the ease of changing those designs as the SSF design evolved and changed. The tasks defined for Micro Craft were to provide the personnel, services, tools, and materials for the SSF mockup which would consist of four modules, nodes, interior components, and part task mockups of MSFC responsible engineering systems. This included the Engineering Control and Life Support Systems (ECLSS) testbed. For the initial study, the mockups were low fidelity, soft mockups of graphics art bottle, and other low cost materials, which evolved into higher fidelity mockups as the R&D design evolved, by modifying or rebuilding, an important cost saving factor in the design process. We designed, fabricated, and maintained the full size mockup shells and support stands. The shells consisted of cylinders, end cones, rings, longerons, docking ports, crew airlocks, and windows. The ECLSS required a heavier cylinder to support the ECLSS systems test program. Details of this activity will be covered. Support stands were

  2. Business process management and IT management: The missing integration

    DEFF Research Database (Denmark)

    Rahimi, Fatemeh; Møller, Charles; Hvam, Lars

    2016-01-01

    of IT on process innovations, the association between business process management and IT management is under-explored. Drawing on a literature analysis of the capabilities of business process and IT governance frameworks and findings from a case study, we propose the need for horizontal integration between the two......The importance of business processes and the centrality of IT to contemporary organizations' performance calls for a specific focus on business process management and IT management. Despite the wide scope of business process management covering both business and IT domains, and the profound impact...... management functions to enable strategic and operational business - IT alignment. We further argue that the role of IT in an organization influences the direction of integration between the two functions and thus the choice of integration mechanisms. Using case study findings, we propose...

  3. Integration of MGDS design into the licensing process

    International Nuclear Information System (INIS)

    1997-12-01

    This paper presents an overview of how the Mined Geologic Disposal System (MGDS) design for a potential repository is integrated into the licensing process. The integration process employs a two-told approach: (1) ensure that the MGDS design complies with applicable Nuclear Regulatory Commission (NRC) licensing requirements, and (2) ensure that the MGDS design is appropriately reflected in a license application that is acceptable to the NRC for performing acceptance and compliance reviews

  4. A path-integral approach to inclusive processes

    International Nuclear Information System (INIS)

    Sukumar, C.V.

    1995-01-01

    The cross section for an inclusive scattering process may be expressed in terms of a double path integral. Evaluation of the double path integral by the stationary-phase approximation yields classical equations of motion for the stationary trajectories and a classical cross section for the inclusive process which depends on the polarization of the initial state. Polarization analyzing powers are calculated from this theory and the results are compared with those obtained in an earlier paper. ((orig.))

  5. Integrated Process Design and Control of Reactive Distillation Processes

    DEFF Research Database (Denmark)

    Mansouri, Seyed Soheil; Sales-Cruz, Mauricio; Huusom, Jakob Kjøbsted

    2015-01-01

    on the element concept, which is used to translate a system of compounds into elements. The operation of the reactive distillation column at the highest driving force and other candidate points is analyzed through analytical solution as well as rigorous open-loop and closed-loop simulations. By application...... of this approach, it is shown that designing the reactive distillation process at the maximum driving force results in an optimal design in terms of controllability and operability. It is verified that the reactive distillation design option is less sensitive to the disturbances in the feed at the highest driving...

  6. Process performance and product quality in an integrated continuous antibody production process.

    Science.gov (United States)

    Karst, Daniel J; Steinebach, Fabian; Soos, Miroslav; Morbidelli, Massimo

    2017-02-01

    Continuous manufacturing is currently being seriously considered in the biopharmaceutical industry as the possible new paradigm for producing therapeutic proteins, due to production cost and product quality related benefits. In this study, a monoclonal antibody producing CHO cell line was cultured in perfusion mode and connected to a continuous affinity capture step. The reliable and stable integration of the two systems was enabled by suitable control loops, regulating the continuous volumetric flow and adapting the operating conditions of the capture process. For the latter, an at-line HPLC measurement of the harvest concentration subsequent to the bioreactor was combined with a mechanistic model of the capture chromatographic unit. Thereby, optimal buffer consumption and productivity throughout the process was realized while always maintaining a yield above the target value of 99%. Stable operation was achieved at three consecutive viable cell density set points (20, 60, and 40 × 10 6 cells/mL), together with consistent product quality in terms of aggregates, fragments, charge isoforms, and N-linked glycosylation. In addition, different values for these product quality attributes such as N-linked glycosylation, charge variants, and aggregate content were measured at the different steady states. As expected, the amount of released DNA and HCP was significantly reduced by the capture step for all considered upstream operating conditions. This study is exemplary for the potential of enhancing product quality control and modulation by integrated continuous manufacturing. Biotechnol. Bioeng. 2017;114: 298-307. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  7. Different cell moieties and white blood cell (WBC) integrity in In-111 labeled WBC preparations

    International Nuclear Information System (INIS)

    Saha, G.B.; Feiglin, D.H.I.; McMahon, J.T.; Go, R.T.; O'Donnell, J.K.; MacIntyre, W.J.

    1985-01-01

    Indium-111 labeled white blood cells (WBC) have become very popular in detecting inflammatory diseases. The purpose of this paper is to determine the distribution of different types of cells in WBC preparation for In-111 oxine labeling, and also to assess the histological integrity of WBC's after labeling with In-111 oxine. Forty to fifty cc of blood was collected from each patient and WBC's were separated by sedimentation and centrifugation. After labeling with In-111 oxine, an aliquot of the WBC sample was used for cell counting and a second aliquot was used for electron microscopic (EM) examination. The different cell moieties were counted, and the mean and standard deviation of twelve determinations calculated. Cells were prepared by the standard technique for electron microscopic examination and images of the cells were obtained at different magnifications (X8,000-25,000). The EM images revealed that although minimal cytoplasmic vacuolization occurred in the WBC's due to the labeling process, the overall histological integrity of the cells remained intact. The relative labeling efficiency of WBC's is greater than those of RBC's and platelets (J Nuc) Med 25:p98, 1984) and, therefore, even a comparatively low population of WBC's gives optimal imaging due to their increased tracer uptake

  8. Diagnosis about Integration process of youth foreign Catalan

    Directory of Open Access Journals (Sweden)

    Marta Sabariego Puig

    2015-09-01

    Full Text Available This paper presents the results of a diagnostic study on the real integration process of young migrants in Catalonia. The study was carried out using a descriptive survey of 3,830 young Catalans from varying cultural backgrounds aged between 14 and 18, with the aim of identifying the key factors influencing the integration of Catalan migrant youth. Also, in order to analyze these key elements in greater depth as factors easing and/or obstructing integration, four discussion groups were held with the same young people. Results reveal achievements and challenges for further study, useful for the design of social and educational policies which may promote the integration process, understood in its structural, social, cognitive-cultural and identitary dimensions. Our study confirms the need for a society with pluralistic beliefs, principles and actions, which should be reflected in democratic systems and social and educational policies based on the concept of integration as reciprocity.

  9. Total site integration of light hydrocarbons separation process

    OpenAIRE

    Ulyev, L.; Vasilyev, M.; Maatouk, A.; Duic, Neven; Khusanovc, Alisher

    2016-01-01

    Ukraine is the largest consumer of hydrocarbons per unit of production in Europe (Ukraine policy review, 2006). The most important point is a reduction of energy consumption in chemical and metallurgical industries as a biggest consumer. This paper deals with energy savings potential of light hydrocarbons separation process. Energy consumption of light hydrocarbons separation process processes typical of Eastern European countries were analysed. Process Integration (PI) was used to perform a ...

  10. Radiation induced processes in moss cells

    International Nuclear Information System (INIS)

    Doehren, R. v.

    1975-01-01

    The moss F.h. shows apical growth in the protonema cells which spread radially from the spor. Every apical daughter cell during the state of 'Caulonema' and just before in the state of 'Caulonema Primanen' initiates cell division as soon as more than twice the length of the mother cell is reached. All this allows to follow radiation effects in single cells conveniently. UV irradiation on the range of 254 nm and 280 nm delivered at different parts of the cell area delays cell division markedly may suppress it, and is able to stop the process of growing in relation to the delivered dose and to the irradiated area as well. In case of irradiation of the area next to where the membrane is just being formed - that is to say next to the phragmoplast - the new membrane will be wrongly oriented. In particular giant cells are occurring in the case of nucleus irradiation during early prophase. (orig./GSE) [de

  11. Optimal integration of organic Rankine cycles with industrial processes

    International Nuclear Information System (INIS)

    Hipólito-Valencia, Brígido J.; Rubio-Castro, Eusiel; Ponce-Ortega, José M.; Serna-González, Medardo; Nápoles-Rivera, Fabricio; El-Halwagi, Mahmoud M.

    2013-01-01

    Highlights: • An optimization approach for heat integration is proposed. • A new general superstructure for heat integration is proposed. • Heat process streams are simultaneously integrated with an organic Rankine cycle. • Better results can be obtained respect to other previously reported methodologies. - Abstract: This paper presents a procedure for simultaneously handling the problem of optimal integration of regenerative organic Rankine cycles (ORCs) with overall processes. ORCs may allow the recovery of an important fraction of the low-temperature process excess heat (i.e., waste heat from industrial processes) in the form of mechanical energy. An integrated stagewise superstructure is proposed for representing the interconnections and interactions between the HEN and ORC for fixed data of process streams. Based on the integrated superstructure, the optimization problem is formulated as a mixed integer nonlinear programming problem to simultaneously account for the capital and operating costs including the revenue from the sale of the shaft power produced by the integrated system. The application of this method is illustrated with three example problems. Results show that the proposed procedure provides significantly better results than an earlier developed method for discovering optimal integrated systems using a sequential approach, due to the fact that it accounts simultaneously for the tradeoffs between the capital and operating costs as well as the sale of the produced energy. Also, the proposed method is an improvement over the previously reported methods for solving the synthesis problem of heat exchanger networks without the option of integration with an ORC (i.e., stand-alone heat exchanger networks)

  12. The mechanism of development of integration processes in the region

    Directory of Open Access Journals (Sweden)

    V. M. Bautin

    2017-01-01

    Full Text Available In the context of the weakening economic development of the region, it is necessary to find new ways to increase the efficiency of interaction between the economic structures of the region. One of the areas is the development of integration processes in the field of cooperation between the public and private capital to meet the goals and objectives of the effective functioning of both the participants of integration interaction, as well as the region as a whole. Factors that influence the emergence and development of integration processes, are a scarce resource; motivated by the need to diversify the business; the desire to improve the economic efficiency of business entities. Development grace-integral process is economic interaction managing subjects, followed by combining them to achieve common objectives and obtain the synergistic effect due to a number of resource solutions, organizational and administrative problems. To obtain high economic benefits of integration interaction of the participants, we have proposed a mechanism for the development of integration processes in the region, based on three levels of interaction between regional authorities, educational institutions and private organizations. It allows forming a single chain integration and process management to increase the effectiveness of their implementation in practice, and to avoid the disadvantages associated with the formation of the integrated structures. Integration cooperation of regional authorities with organizations of various spheres of activity of the region and education (research organizations is a key component of the new Russian innovation policy because, if done right, it provides broader benefits from investments in research and development, creating favorable conditions for sustainable innovation development and is a strategic factor in the economic growth of the region.

  13. Integrated Main Propulsion System Performance Reconstruction Process/Models

    Science.gov (United States)

    Lopez, Eduardo; Elliott, Katie; Snell, Steven; Evans, Michael

    2013-01-01

    The Integrated Main Propulsion System (MPS) Performance Reconstruction process provides the MPS post-flight data files needed for postflight reporting to the project integration management and key customers to verify flight performance. This process/model was used as the baseline for the currently ongoing Space Launch System (SLS) work. The process utilizes several methodologies, including multiple software programs, to model integrated propulsion system performance through space shuttle ascent. It is used to evaluate integrated propulsion systems, including propellant tanks, feed systems, rocket engine, and pressurization systems performance throughout ascent based on flight pressure and temperature data. The latest revision incorporates new methods based on main engine power balance model updates to model higher mixture ratio operation at lower engine power levels.

  14. Integration of process computer systems to Cofrentes NPP

    International Nuclear Information System (INIS)

    Saettone Justo, A.; Pindado Andres, R.; Buedo Jimenez, J.L.; Jimenez Fernandez-Sesma, A.; Delgado Muelas, J.A.

    1997-01-01

    The existence of three different process computer systems in Cofrentes NPP and the ageing of two of them have led to the need for their integration into a single real time computer system, known as Integrated ERIS-Computer System (SIEC), which covers the functionality of the three systems: Process Computer (PC), Emergency Response Information System (ERIS) and Nuclear Calculation Computer (OCN). The paper describes the integration project developed, which has essentially consisted in the integration of PC, ERIS and OCN databases into a single database, the migration of programs from the old process computer into the new SIEC hardware-software platform and the installation of a communications programme to transmit all necessary data for OCN programs from the SIEC computer, which in the new configuration is responsible for managing the databases of the whole system. (Author)

  15. Software features and applications in process design, integration and operation

    Energy Technology Data Exchange (ETDEWEB)

    Dhole, V. [Aspen Tech Limited, Warrington (United Kingdom)

    1999-02-01

    Process engineering technologies and tools have evolved rapidly over the last twenty years. Process simulation/modeling, advanced process control, on-line optimisation, production planning and supply chain management are some of the examples of technologies that have rapidly matured from early commercial prototypes and concepts to established tools with significant impact on profitability of process industry today. Process Synthesis or Process Integration (PI) in comparison is yet to create its impact and still remains largely in the domain of few expert users. One of the key reasons as to why PI has not taken off is because the PI tools have not become integral components of the standard process engineering environments. On the last 15 years AspenTech has grown from a small process simulation tool provider to a large multinational company providing a complete suite of process engineering technologies and services covering process design, operation, planning and supply chain management. Throughout this period, AspenTech has acquired experience in rapidly evolving technologies from their early prototype stage to mature products and services. The paper outlines AspenTech`s strategy of integrating PI with other more established process design and operational improvement technologies. The paper illustrates the key elements of AspenTech`s strategy via examples of software development initiatives and services projects. The paper also outlines AspenTech`s future vision of the role of PI in process engineering. (au)

  16. Defining process design space for monoclonal antibody cell culture.

    Science.gov (United States)

    Abu-Absi, Susan Fugett; Yang, LiYing; Thompson, Patrick; Jiang, Canping; Kandula, Sunitha; Schilling, Bernhard; Shukla, Abhinav A

    2010-08-15

    The concept of design space has been taking root as a foundation of in-process control strategies for biopharmaceutical manufacturing processes. During mapping of the process design space, the multidimensional combination of operational variables is studied to quantify the impact on process performance in terms of productivity and product quality. An efficient methodology to map the design space for a monoclonal antibody cell culture process is described. A failure modes and effects analysis (FMEA) was used as the basis for the process characterization exercise. This was followed by an integrated study of the inoculum stage of the process which includes progressive shake flask and seed bioreactor steps. The operating conditions for the seed bioreactor were studied in an integrated fashion with the production bioreactor using a two stage design of experiments (DOE) methodology to enable optimization of operating conditions. A two level Resolution IV design was followed by a central composite design (CCD). These experiments enabled identification of the edge of failure and classification of the operational parameters as non-key, key or critical. In addition, the models generated from the data provide further insight into balancing productivity of the cell culture process with product quality considerations. Finally, process and product-related impurity clearance was evaluated by studies linking the upstream process with downstream purification. Production bioreactor parameters that directly influence antibody charge variants and glycosylation in CHO systems were identified.

  17. Fuels processing for transportation fuel cell systems

    Science.gov (United States)

    Kumar, R.; Ahmed, S.

    Fuel cells primarily use hydrogen as the fuel. This hydrogen must be produced from other fuels such as natural gas or methanol. The fuel processor requirements are affected by the fuel to be converted, the type of fuel cell to be supplied, and the fuel cell application. The conventional fuel processing technology has been reexamined to determine how it must be adapted for use in demanding applications such as transportation. The two major fuel conversion processes are steam reforming and partial oxidation reforming. The former is established practice for stationary applications; the latter offers certain advantages for mobile systems and is presently in various stages of development. This paper discusses these fuel processing technologies and the more recent developments for fuel cell systems used in transportation. The need for new materials in fuels processing, particularly in the area of reforming catalysis and hydrogen purification, is discussed.

  18. Sustainable Chemical Process Development through an Integrated Framework

    DEFF Research Database (Denmark)

    Papadakis, Emmanouil; Kumar Tula, Anjan; Anantpinijwatna, Amata

    2016-01-01

    This paper describes the development and the application of a general integrated framework based on systematic model-based methods and computer-aided tools with the objective to achieve more sustainable process designs and to improve the process understanding. The developed framework can be appli...... studies involve multiphase reaction systems for the synthesis of active pharmaceutical ingredients....

  19. Integrating Usability Evaluations into the Software Development Process

    DEFF Research Database (Denmark)

    Lizano, Fulvio

    as relevant and strategic human–computer interaction (HCI) activities in the software development process, there are obstacles that limit the complete, effective and efficient integration of this kind of testing into the software development process. Two main obstacles are the cost of usability evaluations...... and the software developers' resistance to accepting users’ opinions regarding the lack of usability in their software systems. The ‘cost obstacle’ refers to the constraint of conducting usability evaluations in the software process due to the significant amount of resources required by this type of testing. Some......This thesis addresses the integration of usability evaluations into the software development process. The integration here is contextualized in terms of how to include usability evaluation as an activity in the software development lifecycle. Even though usability evaluations are considered...

  20. Life cycle assessment of roof integrated solar cell systems

    International Nuclear Information System (INIS)

    Van Brummelen, M.; Nieuwlaar, E.

    1994-01-01

    The research protocol, applied in this report, is designed for use within the energy R and D-context: it provides a framework for finding bottlenecks and opportunities for (new) energy technologies in the context of (energy) resource scarcity and environmental issues. Finding and analyzing these bottlenecks and opportunities is a major objective of this study. A derived objective of this study is to gain experience in using the LCA-framework and the research protocol described earlier, and to evaluate the usefulness of these instruments in helping to find and analyze bottlenecks and opportunities in energy technologies. Photovoltaic solar cell systems (PV systems) are comprised of solar cell modules and a Balance-of-System (BOS): a support structure and power conditioning equipment. In this LCA amorphous silicon cells (a-Si) are considered. For the Netherlands roof-integrated, grid-connected systems are assumed to be the major application of PV in the future. Two cases will be studied. In case 1 a system of 30 m 2 of modules which are connected to the grid via a single inverter are studied. The modules are comprised of a-Si cells and have a conversion efficiency of 10%. Integration into the roof is done with aluminium profiles. In case 2 a system of 30 m 2 a-Si cell modules integrated in the roof with plastic 'tiles' is studied. The modules have an efficiency of 15% and connection to the grid is more or less centralized: 25 systems share an inverter which is connected to the grid. The goal and scope of the LCA and the functional unit are described in chapter 2. In chapter 3 the process tree and descriptions of the distinguished processes are given and the inventory table is drawn up. In chapter 4 the impact assessment is dealt with, followed by a discussion of improvement options in chapter 5. Conclusions and recommendations are given in the chapters 6 and 7 only regarding the environmental aspects. 9 figs., 13 tabs., 4 appendices, 13 refs

  1. Integration of drinking water treatment plant process models and emulated process automation software

    NARCIS (Netherlands)

    Worm, G.I.M.

    2012-01-01

    The objective of this research is to limit the risks of fully automated operation of drinking water treatment plants and to improve their operation by using an integrated system of process models and emulated process automation software. This thesis contains the design of such an integrated system.

  2. Integrating Thermal Tools Into the Mechanical Design Process

    Science.gov (United States)

    Tsuyuki, Glenn T.; Siebes, Georg; Novak, Keith S.; Kinsella, Gary M.

    1999-01-01

    The intent of mechanical design is to deliver a hardware product that meets or exceeds customer expectations, while reducing cycle time and cost. To this end, an integrated mechanical design process enables the idea of parallel development (concurrent engineering). This represents a shift from the traditional mechanical design process. With such a concurrent process, there are significant issues that have to be identified and addressed before re-engineering the mechanical design process to facilitate concurrent engineering. These issues also assist in the integration and re-engineering of the thermal design sub-process since it resides within the entire mechanical design process. With these issues in mind, a thermal design sub-process can be re-defined in a manner that has a higher probability of acceptance, thus enabling an integrated mechanical design process. However, the actual implementation is not always problem-free. Experience in applying the thermal design sub-process to actual situations provides the evidence for improvement, but more importantly, for judging the viability and feasibility of the sub-process.

  3. A comprehensive, holistic people integration process for mergers and acquisitions

    Directory of Open Access Journals (Sweden)

    Rina P. Steynberg

    2011-03-01

    Research purpose: To develop and validate a comprehensive, holistic model for the people integration process during mergers and acquisitions. Motivation for the study: The literature on a comprehensive, holistic people integration process for mergers and acquisitions is sparse and fragmented. Research design, approach and method: A qualitative approach was adopted consisting of a three step process which solicited the views of seasoned M&A Practioners; these views were compared against the available literature. Finally, practioners were asked to critique the final model from a practice perspective. The utility of the final model was assessed against two mergers and acquisitions case studies. Main findings: A comprehensive, holistic people integration process model for mergers and acquisitions was developed and validated. However, this model will only significantly enhance mergers and acquisitions value realisation if it is applied from the appropriate vantage point. Practical/managerial implications: The proposed approach will increase the probability of a successful M&A people-wise and M&A value realisation. Contribution/value add: Theoretically, the development and validation of a M&A people process integration model; practically, guidelines for successful people integration; organisationally, significantly enhancing the chances of M&A success; and community wise, the reduction of the negative effects of M&A failure on communities.

  4. Virtual Collaborative Simulation Environment for Integrated Product and Process Development

    Science.gov (United States)

    Gulli, Michael A.

    1997-01-01

    Deneb Robotics is a leader in the development of commercially available, leading edge three- dimensional simulation software tools for virtual prototyping,, simulation-based design, manufacturing process simulation, and factory floor simulation and training applications. Deneb has developed and commercially released a preliminary Virtual Collaborative Engineering (VCE) capability for Integrated Product and Process Development (IPPD). This capability allows distributed, real-time visualization and evaluation of design concepts, manufacturing processes, and total factory and enterprises in one seamless simulation environment.

  5. Human Processing of Knowledge from Texts: Acquisition, Integration, and Reasoning

    Science.gov (United States)

    1979-06-01

    comprehension. Norwood, N.J.: Ablex, 1977. Craik , F.I.M., and Lockhart , R. S. Levels of processing : for memory research. Journal of Verbal Learning A...Table 5.9 presents summary data regarding the performance levels and memory and search processes of individual subjects. The first row in Table 5.9...R-2256-ARP A June 1979 ARPA Order No.: 189-1 9020 Cybernetics Technology Human Processing of Knowledge from Texts: Acquisition, Integration, and

  6. BATCH PROCESS INTEGRATION OF APPLYING TECHNOLOGY OF ACID CARMINIC PINCH

    OpenAIRE

    Erazo E., Raymundo; Cárdenas R., Jorge L.; Woolcott H., Juan C.

    2014-01-01

    This work was developed in order to implement the PINCH technology integration batch process for carminic acid. The method used consisted of the application of the concepts of bottle necks total process (OPB) together with part-time models (TAM) and time fractionated! (TSM). The drying operation is identified as the rate limiting step of the process identifying it as an OPB plant capacity. The extraction yield was 95% w / p carminic acid with an energy savings of approximately 60% of the...

  7. Test processing integrated system (S.I.D.E.X.)

    International Nuclear Information System (INIS)

    Sabas, M.; Oules, H.; Badel, D.

    1969-01-01

    The Test Processing Integrated System is mostly composed of a CAE 9080 (equiv. S. D. S. 9300) computer which is equipped of a 100 000 samples/sec acquisition system. The System is designed for high speed data acquisition and data processing on environment tests, and also calculation of structural models. Such a digital appliance on data processing has many advantages compared to the conventional methods based on analog instruments. (author) [fr

  8. A Web-Based Integration Procedure for the Development of Reconfigurable Robotic Work-Cells

    OpenAIRE

    Paulo Ferreira; Victoria Reyes; João Mestre

    2013-01-01

    Concepts related to the development of reconfigurable manufacturing systems (RMS) and methodologies to provide the best practices in the processing industry and factory automation, such as system integration and web-based technology, are major issues in designing next-generation manufacturing systems (NGMS). Adaptable and integrable devices are crucial for the success of NGMS. In robotic cells the integration of manufacturing components is essential to accelerate system adaptability. Sensors,...

  9. Brain activity related to integrative processes in visual object recognition

    DEFF Research Database (Denmark)

    Gerlach, Christian; Aaside, C T; Humphreys, G W

    2002-01-01

    We report evidence from a PET activation study that the inferior occipital gyri (likely to include area V2) and the posterior parts of the fusiform and inferior temporal gyri are involved in the integration of visual elements into perceptual wholes (single objects). Of these areas, the fusiform a......) that perceptual and memorial processes can be dissociated on both functional and anatomical grounds. No evidence was obtained for the involvement of the parietal lobes in the integration of single objects....

  10. Computer-integrated electric-arc melting process control system

    OpenAIRE

    Дёмин, Дмитрий Александрович

    2014-01-01

    Developing common principles of completing melting process automation systems with hardware and creating on their basis rational choices of computer- integrated electricarc melting control systems is an actual task since it allows a comprehensive approach to the issue of modernizing melting sites of workshops. This approach allows to form the computer-integrated electric-arc furnace control system as part of a queuing system “electric-arc furnace - foundry conveyor” and consider, when taking ...

  11. Integrating discount usability in scrum development process in Ethiopia

    DEFF Research Database (Denmark)

    Teka, Degif; Dittrich, Y.; Kifle, Mesfin

    2017-01-01

    be adapted and integrated into the Scrum-agile development with especial emphasis on the Ethiopian context. The research aims at adapting software engineering and ICT development methods to the specific situation and integrating user-centered design (UCD) and lightweight usability methods into agile...... end users and developers. Culturally adapted user pair testing and heuristic evaluation supported usability testing and supported developers in getting early feedback. Integrated approach of discount usability with the Scrum process has been developed and evaluated first with the involved...

  12. Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software

    NARCIS (Netherlands)

    Kaiser, Matthias; Jug, Florian; Julou, Thomas; Deshpande, S.R.; Pfohl, Thomas; Silander, Olin K.; Myers, Gene; Van Nimwegen, Erik

    2018-01-01

    Much is still not understood about how gene regulatory interactions control cell fate decisions in single cells, in part due to the difficulty of directly observing gene regulatory processes in vivo. We introduce here a novel integrated setup consisting of a microfluidic chip and accompanying

  13. THE INTEGRATION PROCESS MERCOSUR IN 2007 BY MODEL OF GLOBAL DIMENSION OF REGIONAL INTEGRATION

    Directory of Open Access Journals (Sweden)

    André Bechlin

    2013-04-01

    Full Text Available This paper aimed to analyze the advance of the regional integration process in the MERCOSUR (Southern Common Market, using a model developed for Professor Mario Ruiz Estrada, of the College of Economy and Administration of the University of Kuala Lumpur in Malaysia, the GDRI (Global Dimension of Regional Integration Model and that as characteristic has differentiated the use of other variable for analysis, that not specifically of economic origin, derivatives of the evolution of the commerce processes. When inferring and comparing the external performance of the economies that compose the Mercosur, evaluating itself the impacts of the advance of the process of regional and commercial integration, are evidents the inequalities that exist in the block. However, a common evolution is observed, in the direction of intensification of the integration between the economies, mainly after the process of opening lived for the continent, beyond the advance of the integration in the context of the Mercosur, from the decade of 1990. The analyzed data show that, in the generality, these economies are if integrating to the world-wide market, and in parallel, accenting the integration degree enters the members of the block.

  14. Integrating digital topology in image-processing libraries.

    Science.gov (United States)

    Lamy, Julien

    2007-01-01

    This paper describes a method to integrate digital topology informations in image-processing libraries. This additional information allows a library user to write algorithms respecting topological constraints, for example, a seed fill or a skeletonization algorithm. As digital topology is absent from most image-processing libraries, such constraints cannot be fulfilled. We describe and give code samples for all the structures necessary for this integration, and show a use case in the form of a homotopic thinning filter inside ITK. The obtained filter can be up to a hundred times as fast as ITK's thinning filter and works for any image dimension. This paper mainly deals of integration within ITK, but can be adapted with only minor modifications to other image-processing libraries.

  15. Simplification of Process Integration Studies in Intermediate Size Industries

    DEFF Research Database (Denmark)

    Dalsgård, Henrik; Petersen, P. M.; Qvale, Einar Bjørn

    2002-01-01

    associated with a given process integration study in an intermediate size industry. This is based on the observation that the systems that eventually result from a process integration project and that are economically and operationally most interesting are also quite simple. Four steps that may be used......It can be argued that the largest potential for energy savings based on process integration is in the intermediate size industry. But this is also the industrial scale in which it is most difficult to make the introduction of energy saving measures economically interesting. The reasons......' and therefore lead to non-optimal economic solutions, which may be right. But the objective of the optimisation is not to reach the best economic solution, but to relatively quickly develop the design of a simple and operationally friendly network without losing too much energy saving potential. (C) 2002...

  16. Integration of e-learning outcomes into work processes

    Directory of Open Access Journals (Sweden)

    Kerstin Grundén

    2011-07-01

    Full Text Available Three case studies of in-house developed e-learning education in public organizations with different pedagogical approaches are used as a starting point for discussion regarding the implementation challenges of e-learning at work. The aim of this article is to contribute to the understanding of integrating mechanisms of e-learning outcomes into work processes in large, public organizations. The case studies were analyzed from a socio-cultural perspective using the MOA-model as a frame of reference. Although the pedagogical approaches for all of the cases seemed to be relevant and most of the learners showed overall positive attitudes towards the courses, there were problems with integration of the e-learning outcomes into work processes. There were deficiencies in the adaption of the course contents to the local educational needs. There was also a lack of adjusting the local work organization and work routines in order to facilitate the integration of the e-learning outcomes into the work processes. A lack of local management engagement affected the learners’ motivation negatively. Group discussions in local work groups facilitated the integration of the e-learning outcomes. Much of the difficulties of integrating e-learning outcomes into work processes in big organizations are related to the problems with adjusting centrally developed e-learning courses to local needs and a lack of co-operation among among the developers (often IT-professionals and the Human Resources Department of the organizations.

  17. Process modeling for the Integrated Nonthermal Treatment System (INTS) study

    Energy Technology Data Exchange (ETDEWEB)

    Brown, B.W.

    1997-04-01

    This report describes the process modeling done in support of the Integrated Nonthermal Treatment System (INTS) study. This study was performed to supplement the Integrated Thermal Treatment System (ITTS) study and comprises five conceptual treatment systems that treat DOE contract-handled mixed low-level wastes (MLLW) at temperatures of less than 350{degrees}F. ASPEN PLUS, a chemical process simulator, was used to model the systems. Nonthermal treatment systems were developed as part of the INTS study and include sufficient processing steps to treat the entire inventory of MLLW. The final result of the modeling is a process flowsheet with a detailed mass and energy balance. In contrast to the ITTS study, which modeled only the main treatment system, the INTS study modeled each of the various processing steps with ASPEN PLUS, release 9.1-1. Trace constituents, such as radionuclides and minor pollutant species, were not included in the calculations.

  18. Collaboration process for integrated social and health care strategy implementation.

    Science.gov (United States)

    Korpela, Jukka; Elfvengren, Kalle; Kaarna, Tanja; Tepponen, Merja; Tuominen, Markku

    2012-01-01

    To present a collaboration process for creating a roadmap for the implementation of a strategy for integrated health and social care. The developed collaboration process includes multiple phases and uses electronic group decision support system technology (GDSS). A case study done in the South Karelia District of Social and Health Services in Finland during 2010-2011. An expert panel of 13 participants was used in the planning process of the strategy implementation. The participants were interviewed and observed during the case study. As a practical result, a roadmap for integrated health and social care strategy implementation has been developed. The strategic roadmap includes detailed plans of several projects which are needed for successful integration strategy implementation. As an academic result, a collaboration process to create such a roadmap has been developed. The collaboration process and technology seem to suit the planning process well. The participants of the meetings were satisfied with the collaboration process and the GDSS technology. The strategic roadmap was accepted by the participants, which indicates satisfaction with the developed process.

  19. Collaboration process for integrated social and health care strategy implementation

    Directory of Open Access Journals (Sweden)

    Jukka Korpela

    2012-05-01

    Full Text Available Objective:  To present collaboration process for creating a roadmap for the implementation of a strategy for integrated health and social care. The developed collaboration process includes multiple phases and uses electronic group decision support system technology (GDSS.Method: A case study done in the South Karelia District of Social and Health Services in Finland during 2010 - 2011. An expert panel of 13 participants was used in the planning process of the strategy implementation. The participants were interviewed and observed during the case study.Results: As a practical result, a roadmap for integrated health and social care strategy implementation has been developed. The strategic roadmap includes detailed plans of several projects which are needed for successful integration strategy implementation. As an academic result, a collaboration process to create such a roadmap has been developed.Conclusions: The collaboration process and technology seem to suit the planning process well. The participants of the meetings were satisfied with the collaboration process and the GDSS technology. The strategic roadmap was accepted by the participants, which indicates satisfaction with the developed process.

  20. Design Process for Integrated Concepts with Responsive Building Elements

    DEFF Research Database (Denmark)

    Aa, Van der A.; Heiselberg, Per

    2008-01-01

    An integrated building concept is a prerequisite to come to an energy efficient building with a good and healthy IAQ indoor comfort. A design process that defines the targets and boundary conditions in the very first stage of the design and guarantees them until the building is finished and used...... is needed. The hard question is however: how to make the right choice of the combination of individual measures from building components and building services elements. Within the framework of IEA-ECBCS Annex 44 research has been conducted about the design process for integrated building concepts...

  1. Scheduling of Power System Cells Integrating Stochastic Power Generation

    International Nuclear Information System (INIS)

    Costa, L.M.

    2008-12-01

    Energy supply and climate change are nowadays two of the most outstanding problems which societies have to cope with under a context of increasing energy needs. Public awareness of these problems is driving political willingness to take actions for tackling them in a swift and efficient manner. Such actions mainly focus in increasing energy efficiency, in decreasing dependence on fossil fuels, and in reducing greenhouse gas emissions. In this context, power systems are undergoing important changes in the way they are planned and managed. On the one hand, vertically integrated structures are being replaced by market structures in which power systems are un-bundled. On the other, power systems that once relied on large power generation facilities are witnessing the end of these facilities' life-cycle and, consequently, their decommissioning. The role of distributed energy resources such as wind and solar power generators is becoming increasingly important in this context. However, the large-scale integration of such type of generation presents many challenges due, for instance, to the uncertainty associated to the variability of their production. Nevertheless, advanced forecasting tools may be combined with more controllable elements such as energy storage devices, gas turbines, and controllable loads to form systems that aim to reduce the impacts that may be caused by these uncertainties. This thesis addresses the management under market conditions of these types of systems that act like independent societies and which are herewith named power system cells. From the available literature, a unified view of power system scheduling problems is also proposed as a first step for managing sets of power system cells in a multi-cell management framework. Then, methodologies for performing the optimal day-ahead scheduling of single power system cells are proposed, discussed and evaluated under both a deterministic and a stochastic framework that directly integrates the

  2. Advanced multiresponse process optimisation an intelligent and integrated approach

    CERN Document Server

    Šibalija, Tatjana V

    2016-01-01

    This book presents an intelligent, integrated, problem-independent method for multiresponse process optimization. In contrast to traditional approaches, the idea of this method is to provide a unique model for the optimization of various processes, without imposition of assumptions relating to the type of process, the type and number of process parameters and responses, or interdependences among them. The presented method for experimental design of processes with multiple correlated responses is composed of three modules: an expert system that selects the experimental plan based on the orthogonal arrays; the factor effects approach, which performs processing of experimental data based on Taguchi’s quality loss function and multivariate statistical methods; and process modeling and optimization based on artificial neural networks and metaheuristic optimization algorithms. The implementation is demonstrated using four case studies relating to high-tech industries and advanced, non-conventional processes.

  3. Elements for successful sensor-based process control {Integrated Metrology}

    International Nuclear Information System (INIS)

    Butler, Stephanie Watts

    1998-01-01

    Current productivity needs have stimulated development of alternative metrology, control, and equipment maintenance methods. Specifically, sensor applications provide the opportunity to increase productivity, tighten control, reduce scrap, and improve maintenance schedules and procedures. Past experience indicates a complete integrated solution must be provided for sensor-based control to be used successfully in production. In this paper, Integrated Metrology is proposed as the term for an integrated solution that will result in a successful application of sensors for process control. This paper defines and explores the perceived four elements of successful sensor applications: business needs, integration, components, and form. Based upon analysis of existing successful commercially available controllers, the necessary business factors have been determined to be strong, measurable industry-wide business needs whose solution is profitable and feasible. This paper examines why the key aspect of integration is the decision making process. A detailed discussion is provided of the components of most importance to sensor based control: decision-making methods, the 3R's of sensors, and connectivity. A metric for one of the R's (resolution) is proposed to allow focus on this important aspect of measurement. A form for these integrated components which synergistically partitions various aspects of control at the equipment and MES levels to efficiently achieve desired benefits is recommended

  4. Elements for successful sensor-based process control {Integrated Metrology}

    Science.gov (United States)

    Butler, Stephanie Watts

    1998-11-01

    Current productivity needs have stimulated development of alternative metrology, control, and equipment maintenance methods. Specifically, sensor applications provide the opportunity to increase productivity, tighten control, reduce scrap, and improve maintenance schedules and procedures. Past experience indicates a complete integrated solution must be provided for sensor-based control to be used successfully in production. In this paper, Integrated Metrology is proposed as the term for an integrated solution that will result in a successful application of sensors for process control. This paper defines and explores the perceived four elements of successful sensor applications: business needs, integration, components, and form. Based upon analysis of existing successful commercially available controllers, the necessary business factors have been determined to be strong, measurable industry-wide business needs whose solution is profitable and feasible. This paper examines why the key aspect of integration is the decision making process. A detailed discussion is provided of the components of most importance to sensor based control: decision-making methods, the 3R's of sensors, and connectivity. A metric for one of the R's (resolution) is proposed to allow focus on this important aspect of measurement. A form for these integrated components which synergistically partitions various aspects of control at the equipment and MES levels to efficiently achieve desired benefits is recommended.

  5. Improved Anomaly Detection using Integrated Supervised and Unsupervised Processing

    Science.gov (United States)

    Hunt, B.; Sheppard, D. G.; Wetterer, C. J.

    There are two broad technologies of signal processing applicable to space object feature identification using nonresolved imagery: supervised processing analyzes a large set of data for common characteristics that can be then used to identify, transform, and extract information from new data taken of the same given class (e.g. support vector machine); unsupervised processing utilizes detailed physics-based models that generate comparison data that can then be used to estimate parameters presumed to be governed by the same models (e.g. estimation filters). Both processes have been used in non-resolved space object identification and yield similar results yet arrived at using vastly different processes. The goal of integrating the results of the two is to seek to achieve an even greater performance by building on the process diversity. Specifically, both supervised processing and unsupervised processing will jointly operate on the analysis of brightness (radiometric flux intensity) measurements reflected by space objects and observed by a ground station to determine whether a particular day conforms to a nominal operating mode (as determined from a training set) or exhibits anomalous behavior where a particular parameter (e.g. attitude, solar panel articulation angle) has changed in some way. It is demonstrated in a variety of different scenarios that the integrated process achieves a greater performance than each of the separate processes alone.

  6. The Role of CAD in Enterprise Integration Process

    Directory of Open Access Journals (Sweden)

    M. Ota

    2004-01-01

    Full Text Available This article deals with the problem of the mutual influence between software systems used in enterprise environment and enterprise integration processes. The position of CAD data and CAx systems in the integrated environment of manufacturing enterprises is clarified. As a consequence, the key role of CAx systems used in those companies is emphasized. It is noted that the integration of CAD data is nowadays only on a secondary level, via primarily integrated PDM systems. This limitation is a reason why we are developing a unified communication model focused on product-oriented data. Our approach is based on Internet technologies, so we believe that is independent enough. The proposed system of communication is based on a simple request-replay dialogue. The structure of this model is open and extensible, but we assume supervision supported by an Internet portal.

  7. Integration by cell algorithm for Slater integrals in a spline basis

    International Nuclear Information System (INIS)

    Qiu, Y.; Fischer, C.F.

    1999-01-01

    An algorithm for evaluating Slater integrals in a B-spline basis is introduced. Based on the piecewise property of the B-splines, the algorithm divides the two-dimensional (r 1 , r 2 ) region into a number of rectangular cells according to the chosen grid and implements the two-dimensional integration over each individual cell using Gaussian quadrature. Over the off-diagonal cells, the integrands are separable so that each two-dimensional cell-integral is reduced to a product of two one-dimensional integrals. Furthermore, the scaling invariance of the B-splines in the logarithmic region of the chosen grid is fully exploited such that only some of the cell integrations need to be implemented. The values of given Slater integrals are obtained by assembling the cell integrals. This algorithm significantly improves the efficiency and accuracy of the traditional method that relies on the solution of differential equations and renders the B-spline method more effective when applied to multi-electron atomic systems

  8. Business Process Management Integration Solution in Financial Sector

    Directory of Open Access Journals (Sweden)

    2009-01-01

    Full Text Available It is vital for financial services companies to ensure the rapid implementation of new processes to meet speed-to-market, service quality and compliance requirements. This has to be done against a background of increased complexity. An integrated approach to business processes allows products, processes, systems, data and the applications that underpin them to evolve quickly. Whether it’s providing a loan, setting up an insurance policy, or executing an investment instruction, optimizing the sale-to-fulfillment process will always win new business, cement customer loyalty, and reduce costs. Lack of integration across lending, payments and trading, on the other hand, simply presents competitors who are more efficient with a huge profit opportunity.

  9. A manufacturable process integration approach for graphene devices

    Science.gov (United States)

    Vaziri, Sam; Lupina, Grzegorz; Paussa, Alan; Smith, Anderson D.; Henkel, Christoph; Lippert, Gunther; Dabrowski, Jarek; Mehr, Wolfgang; Östling, Mikael; Lemme, Max C.

    2013-06-01

    In this work, we propose an integration approach for double gate graphene field effect transistors. The approach includes a number of process steps that are key for future integration of graphene in microelectronics: bottom gates with ultra-thin (2 nm) high-quality thermally grown SiO2 dielectrics, shallow trench isolation between devices and atomic layer deposited Al2O3 top gate dielectrics. The complete process flow is demonstrated with fully functional GFET transistors and can be extended to wafer scale processing. We assess, through simulation, the effects of the quantum capacitance and band bending in the silicon substrate on the effective electric fields in the top and bottom gate oxide. The proposed process technology is suitable for other graphene-based devices such as graphene-based hot electron transistors and photodetectors.

  10. Development of Probabilistic Structural Analysis Integrated with Manufacturing Processes

    Science.gov (United States)

    Pai, Shantaram S.; Nagpal, Vinod K.

    2007-01-01

    An effort has been initiated to integrate manufacturing process simulations with probabilistic structural analyses in order to capture the important impacts of manufacturing uncertainties on component stress levels and life. Two physics-based manufacturing process models (one for powdered metal forging and the other for annular deformation resistance welding) have been linked to the NESSUS structural analysis code. This paper describes the methodology developed to perform this integration including several examples. Although this effort is still underway, particularly for full integration of a probabilistic analysis, the progress to date has been encouraging and a software interface that implements the methodology has been developed. The purpose of this paper is to report this preliminary development.

  11. Space Medicine in the Human System Integration Process

    Science.gov (United States)

    Scheuring, Richard A.

    2010-01-01

    This slide presentation reviews the importance of integration of space medicine in the human system of lunar exploration. There is a review of historical precedence in reference to lunar surface operations. The integration process is reviewed in a chart which shows the steps from research to requirements development, requirements integration, design, verification, operations and using the lessons learned, giving more information and items for research. These steps are reviewed in view of specific space medical issues. Some of the testing of the operations are undertaken in an environment that is an analog to the exploration environment. Some of these analog environments are reviewed, and there is some discussion of the benefits of use of an analog environment in testing the processes that are derived.

  12. Integrating Sustainability into the Real Estate Valuation Process: A ...

    African Journals Online (AJOL)

    This paper sought the perception of Nigerian real estate valuers on sustainable development and how sustainability can be integrated into the real estate valuation process in Nigeria. One hundred and sixty Estate Surveyors and Valuers were asked, among others, to rate the significance of a range of sustainability features ...

  13. ESG Integration and the Investment Management Process : Fundamental Investing Reinvented

    NARCIS (Netherlands)

    van Duuren, Emiel; Plantinga, Auke; Scholtens, Bert

    2016-01-01

    We investigate how conventional asset managers account for environmental, social and governance factors (ESG) in their investment process. We do so on the basis of an international survey among fund managers. We find that many conventional managers integrate responsible investing in their investment

  14. Surface light scattering: integrated technology and signal processing

    DEFF Research Database (Denmark)

    Lading, L.; Dam-Hansen, C.; Rasmussen, E.

    1997-01-01

    systems representing increasing levels of integration are considered. It is demonstrated that efficient signal and data processing can be achieved by evaluation of the statistics of the derivative of the instantaneous phase of the detector signal. (C) 1997 Optical Society of America....

  15. A toroidal inductor integrated in a standard CMOS process

    DEFF Research Database (Denmark)

    Vandi, Luca; Andreani, Pietro; Temporiti, Enrico

    2007-01-01

    This paper presents a toroidal inductor integrated in a standard 0.13 um CMOS process. Finite-elements preliminary simulations are provided to prove the validity of the concept. In order to extract fundamental parameters by means of direct calculations, two different and well-known approaches...

  16. Prediction of thermo-mechanical integrity of wafer backend processes

    NARCIS (Netherlands)

    Gonda, V.; Toonder, den J.M.J.; Beijer, J.G.J.; Zhang, G.Q.; Hoofman, R.J.O.M.; Ernst, L.J.; Ernst, L.J.

    2003-01-01

    More than 65% of IC failures are related to thermal and mechanical problems. For wafer backend processes, thermo-mechanical failure is one of the major bottlenecks. The ongoing technological trends like miniaturization, introduction of new materials, and function/product integration will increase

  17. Aging Effect on Audiovisual Integrative Processing in Spatial Discrimination Task

    Directory of Open Access Journals (Sweden)

    Zhi Zou

    2017-11-01

    Full Text Available Multisensory integration is an essential process that people employ daily, from conversing in social gatherings to navigating the nearby environment. The aim of this study was to investigate the impact of aging on modulating multisensory integrative processes using event-related potential (ERP, and the validity of the study was improved by including “noise” in the contrast conditions. Older and younger participants were involved in perceiving visual and/or auditory stimuli that contained spatial information. The participants responded by indicating the spatial direction (far vs. near and left vs. right conveyed in the stimuli using different wrist movements. electroencephalograms (EEGs were captured in each task trial, along with the accuracy and reaction time of the participants’ motor responses. Older participants showed a greater extent of behavioral improvements in the multisensory (as opposed to unisensory condition compared to their younger counterparts. Older participants were found to have fronto-centrally distributed super-additive P2, which was not the case for the younger participants. The P2 amplitude difference between the multisensory condition and the sum of the unisensory conditions was found to correlate significantly with performance on spatial discrimination. The results indicated that the age-related effect modulated the integrative process in the perceptual and feedback stages, particularly the evaluation of auditory stimuli. Audiovisual (AV integration may also serve a functional role during spatial-discrimination processes to compensate for the compromised attention function caused by aging.

  18. Testing the Box-Cox Parameter for an Integrated Process

    NARCIS (Netherlands)

    J. Huang (Jian); M. Kobayashi (Masahito); M.J. McAleer (Michael)

    2011-01-01

    textabstractThis paper analyses the constant elasticity of volatility (CEV) model suggested by Chan et al. (1992). The CEV model without mean reversion is shown to be the inverse Box-Cox transformation of integrated processes asymptotically. It is demonstrated that the maximum likelihood estimator

  19. Integrating the Medical Home into the EHDI Process

    Science.gov (United States)

    Munoz, Karen F.; Nelson, Lauri; Bradham, Tamala S.; Hoffman, Jeff; Houston, K. Todd

    2011-01-01

    State coordinators of early hearing detection and intervention (EHDI) programs completed a strengths, weaknesses, opportunities, and threats, or SWOT, analysis that examined 12 areas within state EHDI programs. Related to how the medical home is integrated into the EHDI process, 273 items were listed by 48 coordinators, and themes were identified…

  20. A study on development of Pyro process integrated inactive demonstration facility

    International Nuclear Information System (INIS)

    Cho, I.; Lee, E.; Choung, W.; You, G.; Kim, H.

    2010-10-01

    Since 2007, the Pride (Pyro process integrated inactive demonstration facility) has been developed to demonstrate the integrated engineering-scale pyro processing using natural uranium with surrogate materials. In this paper, safety evaluation on hypothetical accident case is carried out to ensure the release of radioactivity being negligible to the environment and the performance of indoor argon flow for the argon cell has been investigated by means of CFD analysis. The worst accident case, even in the firing of the all uranium metal in argon cell, cause dose rate are negligible comparing to 0.25 Sv of effective dose rate to whole body or 3 Sv of equivalent dose rate to the thyroid preliminary CFD analyses show the temperature and velocity distribution of argon cell, and give the information to change the argon exchange rate and displace the argon supply or exhaust duct. CFD will allow design change and improvements in ventilation systems at lower cost. (Author)

  1. An integrated computer aided system for integrated design of chemical processes

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Hytoft, Glen; Jaksland, Cecilia

    1997-01-01

    In this paper, an Integrated Computer Aided System (ICAS), which is particularly suitable for solving problems related to integrated design of chemical processes; is presented. ICAS features include a model generator (generation of problem specific models including model simplification and model ...... form the basis for the toolboxes. The available features of ICAS are highlighted through a case study involving the separation of binary azeotropic mixtures. (C) 1997 Elsevier Science Ltd....

  2. Natural killer cell signal integration balances synapse symmetry and migration.

    Directory of Open Access Journals (Sweden)

    Fiona J Culley

    2009-07-01

    Full Text Available Natural killer (NK cells discern the health of other cells by recognising the balance of activating and inhibitory ligands expressed by each target cell. However, how the integration of activating and inhibitory signals relates to formation of the NK cell immune synapse remains a central question in our understanding of NK cell recognition. Here we report that ligation of LFA-1 on NK cells induced asymmetrical cell spreading and migration. In contrast, ligation of the activating receptor NKG2D induced symmetrical spreading of ruffled lamellipodia encompassing a dynamic ring of f-actin, concurrent with polarization towards a target cell and a "stop" signal. Ligation of both LFA-1 and NKG2D together resulted in symmetrical spreading but co-ligation of inhibitory receptors reverted NK cells to an asymmetrical migratory configuration leading to inhibitory synapses being smaller and more rapidly disassembled. Using micropatterned activating and inhibitory ligands, signals were found to be continuously and locally integrated during spreading. Together, these data demonstrate that NK cells spread to form large, stable, symmetrical synapses if activating signals dominate, whereas asymmetrical migratory "kinapses" are favoured if inhibitory signals dominate. This clarifies how the integration of activating and inhibitory receptor signals is translated to an appropriate NK cell response.

  3. Hydrogen storage and integrated fuel cell assembly

    Science.gov (United States)

    Gross, Karl J.

    2010-08-24

    Hydrogen is stored in materials that absorb and desorb hydrogen with temperature dependent rates. A housing is provided that allows for the storage of one or more types of hydrogen-storage materials in close thermal proximity to a fuel cell stack. This arrangement, which includes alternating fuel cell stack and hydrogen-storage units, allows for close thermal matching of the hydrogen storage material and the fuel cell stack. Also, the present invention allows for tailoring of the hydrogen delivery by mixing different materials in one unit. Thermal insulation alternatively allows for a highly efficient unit. Individual power modules including one fuel cell stack surrounded by a pair of hydrogen-storage units allows for distribution of power throughout a vehicle or other electric power consuming devices.

  4. Cell Culture Systems To Study Human Herpesvirus 6A/B Chromosomal Integration.

    Science.gov (United States)

    Gravel, Annie; Dubuc, Isabelle; Wallaschek, Nina; Gilbert-Girard, Shella; Collin, Vanessa; Hall-Sedlak, Ruth; Jerome, Keith R; Mori, Yasuko; Carbonneau, Julie; Boivin, Guy; Kaufer, Benedikt B; Flamand, Louis

    2017-07-15

    Human herpesviruses 6A/B (HHV-6A/B) can integrate their viral genomes in the telomeres of human chromosomes. The viral and cellular factors contributing to HHV-6A/B integration remain largely unknown, mostly due to the lack of efficient and reproducible cell culture models to study HHV-6A/B integration. In this study, we characterized the HHV-6A/B integration efficiencies in several human cell lines using two different approaches. First, after a short-term infection (5 h), cells were processed for single-cell cloning and analyzed for chromosomally integrated HHV-6A/B (ciHHV-6A/B). Second, cells were infected with HHV-6A/B and allowed to grow in bulk for 4 weeks or longer and then analyzed for the presence of ciHHV-6. Using quantitative PCR (qPCR), droplet digital PCR, and fluorescent in situ hybridization, we could demonstrate that HHV-6A/B integrated in most human cell lines tested, including telomerase-positive (HeLa, MCF-7, HCT-116, and HEK293T) and telomerase-negative cell lines (U2OS and GM847). Our results also indicate that inhibition of DNA replication, using phosphonoacetic acid, did not affect HHV-6A/B integration. Certain clones harboring ciHHV-6A/B spontaneously express viral genes and proteins. Treatment of cells with phorbol ester or histone deacetylase inhibitors triggered the expression of many viral genes, including U39 , U90 , and U100 , without the production of infectious virus, suggesting that the tested stimuli were not sufficient to trigger full reactivation. In summary, both integration models yielded comparable results and should enable the identification of viral and cellular factors contributing to HHV-6A/B integration and the screening of drugs influencing viral gene expression, as well as the release of infectious HHV-6A/B from the integrated state. IMPORTANCE The analysis and understanding of HHV-6A/B genome integration into host DNA is currently limited due to the lack of reproducible and efficient viral integration systems. In the

  5. Process and overview of diagnostics integration in ITER ports

    International Nuclear Information System (INIS)

    Drevon, J.M.; Walsh, M.; Andrew, P.; Barnsley, R.; Bertalot, L.; Bock, M. de; Bora, D.; Bouhamou, R.; Direz, M.F.; Encheva, A.; Fang, T.; Feder, R.; Giacomin, T.; Hellermann, M. von; Jakhar, S.; Johnson, D.; Kaschuk, Y.; Kusama, Y.; Lee, H.G.; Levesy, B.

    2013-01-01

    Highlights: ► An overview of the Port Integration hardware for tenant system hosting inside ITER diagnostics ports is given. ► The main challenges for diagnostic port integration engineering are presented. ► The actions taken for a common modular approach and a coordinated design are detailed. -- Abstract: ITER will have a set of 45 diagnostics to ensure controlled operation. Many of them are integrated in the ITER ports. This paper addresses the integration process of the diagnostic systems and the approach taken to enable coordinated progress. An overview of the Port Integration hardware introduces the various structures needed for hosting tenant systems inside ITER diagnostics ports. The responsibilities of the different parties involved (ITER Organization and the Domestic Agencies) are outlined. The main challenges for diagnostic port integration engineering are summarized. The plan for a common approach to design and manufacture of the supporting structures, in particular the Port Plug is detailed. A coordinated design including common components and a common approach for neutronic analyses is proposed. One particular port, the equatorial port 11, is used to illustrate the approach

  6. AAVS1-Targeted Plasmid Integration in AAV Producer Cell Lines.

    Science.gov (United States)

    Luo, Yuxia; Frederick, Amy; Martin, John M; Scaria, Abraham; Cheng, Seng H; Armentano, Donna; Wadsworth, Samuel C; Vincent, Karen A

    2017-06-01

    Adeno-associated virus (AAV) producer cell lines are created via transfection of HeLaS3 cells with a single plasmid containing three components (the vector sequence, the AAV rep and cap genes, and a selectable marker gene). As this plasmid contains both the cis (Rep binding sites) and trans (Rep protein encoded by the rep gene) elements required for site-specific integration, it was predicted that plasmid integration might occur within the AAVS1 locus on human chromosome 19 (chr19). The objective of this study was to investigate whether integration in AAVS1 might be correlated with vector yield. Plasmid integration sites within several independent cell lines were assessed via Southern, fluorescence in situ hybridization (FISH) and PCR analyses. In the Southern analyses, the presence of fragments detected by both rep- and AAVS1-specific probes suggested that for several mid- and high-producing lines, plasmid DNA had integrated into the AAVS1 locus. Analysis with puroR and AAVS1-specific probes suggested that integration in AAVS1 was a more widespread phenomenon. High-producing AAV2-secreted alkaline phosphatase (SEAP) lines (masterwell 82 [MW82] and MW278) were evaluated via FISH using probes specific for the plasmid, AAVS1, and a chr19 marker. FISH analysis detected two plasmid integration sites in MW278 (neither in AAVS1), while a total of three sites were identified in MW82 (two in AAVS1). An inverse PCR assay confirmed integration within AAVS1 for several mid- and high-producing lines. In summary, the FISH, Southern, and PCR data provide evidence of site-specific integration of the plasmid within AAVS1 in several AAV producer cell lines. The data also suggest that integration in AAVS1 is a general phenomenon that is not necessarily restricted to high producers. The results also suggest that plasmid integration within the AAVS1 locus is not an absolute requirement for a high vector yield.

  7. Moral Judgment as Information Processing: An Integrative Review

    Directory of Open Access Journals (Sweden)

    Steve eGuglielmo

    2015-10-01

    Full Text Available This article reviews dominant models of moral judgment, organizing them within an overarching framework of information processing. This framework poses two fundamental questions: (1 What input information guides moral judgments?; and (2 What psychological processes generate these judgments? Information Models address the first question, identifying critical information elements (including causality, intentionality, and mental states that shape moral judgments. A subclass of Biased Information Models holds that perceptions of these information elements are themselves driven by prior moral judgments. Processing Models address the second question, and existing models have focused on the relative contribution of intuitive versus deliberative processes. This review organizes existing moral judgment models within this framework, critically evaluates them on empirical and theoretical grounds, outlines a general integrative model grounded in information processing, and offers conceptual and methodological suggestions for future research. The information processing perspective provides a useful theoretical framework for organizing extant and future work in the rapidly growing field of moral judgment.

  8. Behavioural design: A process for integrating behaviour change and design

    DEFF Research Database (Denmark)

    Cash, Philip; Hartlev, Charlotte Gram; Durazo, Christine Boysen

    2017-01-01

    Nudge, persuasion, and the influencing of human behaviour through design are increasingly important topics in design research and in the wider public consciousness. However, current theoretical approaches to behaviour change have yet to be operationalized this in design process support....... Specifically, there are few empirically grounded processes supporting designers in realising behaviour change projects. In response to this, 20 design projects from a case company are analysed in order to distil a core process for behavioural design. Results show a number of process stages and activities...... associated with project success, pointing to a new perspective on the traditional design process, and allowing designers to integrate key insights from behaviour change theory. Using this foundation we propose the Behavioural Design process....

  9. Integrated and Modular Design of an Optimized Process Architecture

    Directory of Open Access Journals (Sweden)

    Colin Raßfeld

    2013-07-01

    Full Text Available Global economic integration increased the complexity of business activities, so organizations are forced to become more efficient each day. Process organization is a very useful way of aligning organizational systems towards business processes. However, an organization must do more than just focus its attention and efforts on processes. The layout design has also a significant impact on the system performance.. We contribute to this field by developing a tailored process-oriented organizational structure and new layout design for the quality assurance of a leading German automotive manufacturer. The target concept we developed was evaluated by process owners and an IT-based process simulation. Our results provide solid empirical back-up in which the performance and effects are  assessed from a qualitative and quantitative perspective

  10. Ontological Analysis of Integrated Process Models: testing hypotheses

    Directory of Open Access Journals (Sweden)

    Michael Rosemann

    2001-11-01

    Full Text Available Integrated process modeling is achieving prominence in helping to document and manage business administration and IT processes in organizations. The ARIS framework is a popular example for a framework of integrated process modeling not least because it underlies the 800 or more reference models embedded in the world's most popular ERP package, SAP R/3. This paper demonstrates the usefulness of the Bunge-Wand-Weber (BWW representation model for evaluating modeling grammars such as those constituting ARIS. It reports some initial insights gained from pilot testing Green and Rosemann's (2000 evaluative propositions. Even when considering all five views of ARIS, modelers have problems representing business rules, the scope and boundary of systems, and decomposing models. However, even though it is completely ontologically redundant, users still find the function view useful in modeling.

  11. Integral management of the hazardous merchandise logistics process

    International Nuclear Information System (INIS)

    Moran, M.

    2003-01-01

    Because of the out sourcing of transportation operations and complementary services by producers and carriers, there has been a growing demand for global services that integrate the entire value chain of external logistics, which is understood to be the process including storage, transportation (modal or bi-multimodal) and end delivery. This circumstance has force transportation companies to undertake a process of internal transformation: from providing mere transportation services to becoming logistic operators. Express Truck, S. A. (hereinafter ETSA) could not overlook this market need. Following is a description of ETSA's process of evolution in this line of business. (Author)

  12. Spatial memory and integration processes in congenital blindness.

    Science.gov (United States)

    Vecchi, Tomaso; Tinti, Carla; Cornoldi, Cesare

    2004-12-22

    The paper tests the hypothesis that difficulties met by the blind in spatial processing are due to the simultaneous treatment of independent spatial representations. Results showed that lack of vision does not impede the ability to process and transform mental images; however, blind people are significantly poorer in the recall of more than a single spatial pattern at a time than in the recall of the corresponding material integrated into a single pattern. It is concluded that the simultaneous maintenance of different spatial information is affected by congenital blindness, while cognitive processes that may involve sequential manipulation are not.

  13. Biorefineries to integrate fuel, energy and chemical production processes

    Directory of Open Access Journals (Sweden)

    Enrica Bargiacchi

    2007-12-01

    Full Text Available The world of renewable energies is in fast evolution and arouses political and public interests, especially as an opportunity to boost environmental sustainability by mitigation of greenhouse gas emissions. This work aims at examining the possibilities related to the development of biorefineries, where biomass conversion processes to produce biofuels, electricity and biochemicals are integrated. Particular interest is given to the production processes of biodiesel, bioethanol and biogas, for which present world situation, problems, and perspectives are drawn. Potential areas for agronomic and biotech researches are also discussed. Producing biomass for biorefinery processing will eventually lead to maximize yields, in the non food agriculture.

  14. Future CO2 removal from pulp mills - Process integration consequences

    International Nuclear Information System (INIS)

    Hektor, Erik; Berntsson, Thore

    2007-01-01

    Earlier work has shown that capturing the CO 2 from flue gases in the recovery boiler at a pulp mill can be a cost-effective way of reducing mill CO 2 emissions. However, the CO 2 capture cost is very dependent on the fuel price. In this paper, the potential for reducing the need for external fuel and thereby the possibility to reduce the cost for capturing the CO 2 are investigated. The reduction is achieved by using thermal process integration. In alternative 1, the mill processes are integrated and a steam surplus made available for CO 2 capture, but still there is a need for external fuel. In alternative 2, the integration is taken one step further, the reboiler is fed with MP steam, and the heat of absorption from the absorption unit is used for generation of LP steam needed at the mill. The avoidance costs are in both cases lower than before the process integration. The avoidance cost in alternative 1 varies between 25.4 and 30.7 EUR/tonne CO 2 depending on the energy market parameters. For alternative 2, the cost varies between 22.5 and 27.2 EUR/tonne CO 2 . With tough CO 2 reduction targets and correspondingly high CO 2 emission costs, the annual earnings can be substantial, 18.6 MEUR with alternative 1 and 21.2 MEUR with alternative 2

  15. Attention Modulates the Neural Processes Underlying Multisensory Integration of Emotion

    Directory of Open Access Journals (Sweden)

    Hao Tam Ho

    2011-10-01

    Full Text Available Integrating emotional information from multiple sensory modalities is generally assumed to be a pre-attentive process (de Gelder et al., 1999. This assumption, however, presupposes that the integrative process occurs independent of attention. Using event-potentials (ERP the present study investigated whether the neural processes underlying the integration of dynamic facial expression and emotional prosody is indeed unaffected by attentional manipulations. To this end, participants were presented with congruent and incongruent face-voice combinations (eg, an angry face combined with a neutral voice and performed different two-choice tasks in four consecutive blocks. Three of the tasks directed the participants' attention to emotion expressions in the face, the voice or both. The fourth task required participants to attend to the synchronicity between voice and lip movements. The results show divergent modulations of early ERP components by the different attentional manipulations. For example, when attention was directed to the face (or the voice, incongruent stimuli elicited a reduced N1 as compared to congruent stimuli. This effect was absent, when attention was diverted away from the emotionality in both face and voice suggesting that the detection of emotional incongruence already requires attention. Based on these findings, we question whether multisensory integration of emotion occurs indeed pre-attentively.

  16. CIPSS [computer-integrated process and safeguards system]: The integration of computer-integrated manufacturing and robotics with safeguards, security, and process operations

    International Nuclear Information System (INIS)

    Leonard, R.S.; Evans, J.C.

    1987-01-01

    This poster session describes the computer-integrated process and safeguards system (CIPSS). The CIPSS combines systems developed for factory automation and automated mechanical functions (robots) with varying degrees of intelligence (expert systems) to create an integrated system that would satisfy current and emerging security and safeguards requirements. Specifically, CIPSS is an extension of the automated physical security functions concepts. The CIPSS also incorporates the concepts of computer-integrated manufacturing (CIM) with integrated safeguards concepts, and draws upon the Defense Advance Research Project Agency's (DARPA's) strategic computing program

  17. Solution-Processed Molecular Organic Solar cell: Relationship between Morphology and Device Performance

    KAUST Repository

    Babics, Maxime

    2018-01-01

    ) the rationalization of material design and (ii) systematic optimization of film processing condition. OPV can have a key role in markets such as building-integrated photovoltaics (BIPV). The main advantages of organic solar cells are semitransparency, low weight, good

  18. Integration of Solar Cells on Top of CMOS Chips - Part II: CIGS Solar Cells

    NARCIS (Netherlands)

    Lu, J.; Liu, Wei; Kovalgin, Alexeij Y.; Sun, Yun; Schmitz, Jurriaan

    2011-01-01

    We present the monolithic integration of deepsubmicrometer complementary metal–oxide–semiconductor (CMOS) microchips with copper indium gallium (di)selenide (CIGS) solar cells. Solar cells are manufactured directly on unpackaged CMOS chips. The microchips maintain comparable electronic performance,

  19. Integrated system of production information processing for surface mines

    Energy Technology Data Exchange (ETDEWEB)

    Li, K.; Wang, S.; Zeng, Z.; Wei, J.; Ren, Z. [China University of Mining and Technology, Xuzhou (China). Dept of Mining Engineering

    2000-09-01

    Based on the concept of geological statistic, mathematical program, condition simulation, system engineering, and the features and duties of each main department in surface mine production, an integrated system for surface mine production information was studied systematically and developed by using the technology of data warehousing, CAD, object-oriented and system integration, which leads to the systematizing and automating of the information management, data processing, optimization computing and plotting. In this paper, its overall object, system design, structure and functions and some key techniques were described. 2 refs., 3 figs.

  20. Integrated treatment process of hazardous and mixed wastes

    International Nuclear Information System (INIS)

    Shibuya, M.; Suzuki, K.; Fujimura, Y.; Nakashima, T.; Moriya, Y.

    1993-01-01

    An integrated waste treatment system was studied based on technologies developed for the treatment of liquid radioactive, organic, and aqueous wastes containing hazardous materials and soils contaminated with heavy metals. The system consists of submerged incineration, metal ion fixing and stabilization, and soil washing treatments. Introduction of this system allows for the simultaneous processing of toxic waste and contaminated soils. Hazardous organic wastes can be decomposed into harmless gases, and aqueous wastes can be converted into a dischargeable effluent. The contaminated soil is backfilled after the removal of toxic materials. Experimental data show that the integration system is practical for complicated toxic wastes

  1. Defending the scientific integrity of conservation-policy processes.

    Science.gov (United States)

    Carroll, Carlos; Hartl, Brett; Goldman, Gretchen T; Rohlf, Daniel J; Treves, Adrian; Kerr, Jeremy T; Ritchie, Euan G; Kingsford, Richard T; Gibbs, Katherine E; Maron, Martine; Watson, James E M

    2017-10-01

    Government agencies faced with politically controversial decisions often discount or ignore scientific information, whether from agency staff or nongovernmental scientists. Recent developments in scientific integrity (the ability to perform, use, communicate, and publish science free from censorship or political interference) in Canada, Australia, and the United States demonstrate a similar trajectory. A perceived increase in scientific-integrity abuses provokes concerted pressure by the scientific community, leading to efforts to improve scientific-integrity protections under a new administration. However, protections are often inconsistently applied and are at risk of reversal under administrations publicly hostile to evidence-based policy. We compared recent challenges to scientific integrity to determine what aspects of scientific input into conservation policy are most at risk of political distortion and what can be done to strengthen safeguards against such abuses. To ensure the integrity of outbound communications from government scientists to the public, we suggest governments strengthen scientific integrity policies, include scientists' right to speak freely in collective-bargaining agreements, guarantee public access to scientific information, and strengthen agency culture supporting scientific integrity. To ensure the transparency and integrity with which information from nongovernmental scientists (e.g., submitted comments or formal policy reviews) informs the policy process, we suggest governments broaden the scope of independent reviews, ensure greater diversity of expert input and transparency regarding conflicts of interest, require a substantive response to input from agencies, and engage proactively with scientific societies. For their part, scientists and scientific societies have a responsibility to engage with the public to affirm that science is a crucial resource for developing evidence-based policy and regulations in the public interest.

  2. Radiopeptide internalisation and externalization assays: cell viability and radioligand integrity.

    Science.gov (United States)

    Naqvi, Syed Ali Raza; Sosabowski, Jane K; Nagra, Saeed Ahamad; Ishfaq, Malik M; Mather, Stephen J; Matzow, Torkjel

    2011-01-01

    Various aspects of radiopeptide receptor-mediated cell internalisation and externalization assays were assessed, including the integrity of externalized peptides and the effect of varying the pH and incubation time of the acid wash step (to remove surface receptor-bound ligand) on efficacy and cell viability. The observed intact proportion of externalized peptide was 5-10%, and acid wash buffers with pH 2.8 or below were found to be detrimental to cell viability and integrity, particularly following prolonged incubation times. Copyright © 2010 Elsevier Ltd. All rights reserved.

  3. Radiopeptide internalisation and externalisation assays: Cell viability and radioligand integrity

    International Nuclear Information System (INIS)

    Raza Naqvi, Syed Ali; Sosabowski, Jane K.; Ahamad Nagra, Saeed; Ishfaq, Malik M.; Mather, Stephen J.; Matzow, Torkjel

    2011-01-01

    Various aspects of radiopeptide receptor-mediated cell internalisation and externalisation assays were assessed, including the integrity of externalised peptides and the effect of varying the pH and incubation time of the acid wash step (to remove surface receptor-bound ligand) on efficacy and cell viability. The observed intact proportion of externalised peptide was 5-10%, and acid wash buffers with pH 2.8 or below were found to be detrimental to cell viability and integrity, particularly following prolonged incubation times.

  4. Integrated fuel cell stack shunt current prevention arrangement

    Energy Technology Data Exchange (ETDEWEB)

    Roche, Robert P. (Cheshire, CT); Nowak, Michael P. (Bolton, CT)

    1992-01-01

    A fuel cell stack includes a plurality of fuel cells juxtaposed with one another in the stack and each including a pair of plate-shaped anode and cathode electrodes that face one another, and a quantity of liquid electrolyte present at least between the electrodes. A separator plate is interposed between each two successive electrodes of adjacent ones of the fuel cells and is unified therewith into an integral separator plate. Each integral separator plate is provided with a circumferentially complete barrier that prevents flow of shunt currents onto and on an outer peripheral surface of the separator plate. This barrier consists of electrolyte-nonwettable barrier members that are accommodated, prior to the formation of the integral separator plate, in corresponding edge recesses situated at the interfaces between the electrodes and the separator plate proper. Each barrier member extends over the entire length of the associated marginal portion and is flush with the outer periphery of the integral separator plate. This barrier also prevents cell-to-cell migration of any electrolyte that may be present at the outer periphery of the integral separator plate while the latter is incorporated in the fuel cell stack.

  5. Sustaining high energy efficiency in existing processes with advanced process integration technology

    International Nuclear Information System (INIS)

    Zhang, Nan; Smith, Robin; Bulatov, Igor; Klemeš, Jiří Jaromír

    2013-01-01

    Highlights: ► Process integration with better modelling and more advanced solution methods. ► Operational changes for better environmental performance through optimisation. ► Identification of process integration technology for operational optimisation. ► Systematic implementation procedure of process integration technology. ► A case study with crude oil distillation to demonstrate the operational flexibility. -- Abstract: To reduce emissions in the process industry, much emphasis has been put on making step changes in emission reduction, by developing new process technology and making renewable energy more affordable. However, the energy saving potential of existing systems cannot be simply ignored. In recent years, there have been significant advances in process integration technology with better modelling techniques and more advanced solution methods. These methods have been applied to the new design and retrofit studies in the process industry. Here attempts are made to apply these technologies to improve the environmental performance of existing facilities with operational changes. An industrial project was carried out to demonstrate the importance and effectiveness of exploiting the operational flexibility for energy conservation. By applying advanced optimisation technique to integrate the operation of distillation and heat recovery in a crude oil distillation unit, the energy consumption was reduced by 8% without capital expenditure. It shows that with correctly identified technology and the proper execution procedure, significant energy savings and emission reduction can be achieved very quickly without major capital expenditure. This allows the industry to improve its economic and environment performance at the same time.

  6. The nurses' work process in different countries: an integrative review

    Directory of Open Access Journals (Sweden)

    Juliana Alves Leite Leal

    Full Text Available ABSTRACT Objective: To analyze the characteristics of nurses' work process in different countries. Method: We have used the integrative review method and selected 84 publications (articles, theses and dissertations in national and foreign thesis banks and databases. We analyzed the evidence based on dialectical materialism. Results: The rejection of managerial tasks hides the singularity of nurses' work, due to the failure to understand the inseparable nature of managerial and healthcare tasks, given that it is what provides the expertise to coordinate the nursing work process and guide the healthcare work processes. The social and technical division is present in the work process in all countries studied, albeit in different ways. The nurse's position in the healthcare work process is subordinated to that of the physician. Conclusion: The characteristics are similar. The rejection of the dual nature of the work by nurses themselves due to alienation results in the non-recognition of their own work.

  7. Integration of disabled people in an automated work process

    Science.gov (United States)

    Jalba, C. K.; Muminovic, A.; Epple, S.; Barz, C.; Nasui, V.

    2017-05-01

    Automation processes enter more and more into all areas of life and production. Especially people with disabilities can hardly keep step with this change. In sheltered workshops in Germany people with physical and mental disabilities get help with much dedication, to be integrated into the work processes. This work shows that cooperation between disabled people and industrial robots by means of industrial image processing can successfully result in the production of highly complex products. Here is described how high-pressure hydraulic pumps are assembled by people with disabilities in cooperation with industrial robots in a sheltered workshop. After the assembly process, the pumps are checked for leaks at very high pressures in a completely automated process.

  8. Mess management in microbial ecology: Rhetorical processes of disciplinary integration

    Science.gov (United States)

    McCracken, Christopher W.

    As interdisciplinary work becomes more common in the sciences, research into the rhetorical processes mediating disciplinary integration becomes more vital. This dissertation, which takes as its subject the integration of microbiology and ecology, combines a postplural approach to rhetoric of science research with Victor Turner's "social drama" analysis and a third-generation activity theory methodological framework to identify conceptual and practical conflicts in interdisciplinary work and describe how, through visual and verbal communication, scientists negotiate these conflicts. First, to understand the conflicting disciplinary principles that might impede integration, the author conducts a Turnerian analysis of a disciplinary conflict that took place in the 1960s and 70s, during which American ecologists and biologists debated whether they should participate in the International Biological Program (IBP). Participation in the IBP ultimately contributed to the emergence of ecology as a discipline distinct from biology, and Turnerian social drama analysis of the debate surrounding participation lays bare the conflicting principles separating biology and ecology. Second, to answer the question of how these conflicting principles are negotiated in practice, the author reports on a yearlong qualitative study of scientists working in a microbial ecology laboratory. Focusing specifically on two case studies from this fieldwork that illustrate the key concept of textually mediated disciplinary integration, the author's analysis demonstrates how scientific objects emerge in differently situated practices, and how these objects manage to cohere despite their multiplicity through textually mediated rhetorical processes of calibration and alignment.

  9. IOTA: integration optimization, triage and analysis tool for the processing of XFEL diffraction images.

    Science.gov (United States)

    Lyubimov, Artem Y; Uervirojnangkoorn, Monarin; Zeldin, Oliver B; Brewster, Aaron S; Murray, Thomas D; Sauter, Nicholas K; Berger, James M; Weis, William I; Brunger, Axel T

    2016-06-01

    Serial femtosecond crystallography (SFX) uses an X-ray free-electron laser to extract diffraction data from crystals not amenable to conventional X-ray light sources owing to their small size or radiation sensitivity. However, a limitation of SFX is the high variability of the diffraction images that are obtained. As a result, it is often difficult to determine optimal indexing and integration parameters for the individual diffraction images. Presented here is a software package, called IOTA , which uses a grid-search technique to determine optimal spot-finding parameters that can in turn affect the success of indexing and the quality of integration on an image-by-image basis. Integration results can be filtered using a priori information about the Bravais lattice and unit-cell dimensions and analyzed for unit-cell isomorphism, facilitating an improvement in subsequent data-processing steps.

  10. Integrating physiological regulation with stem cell and tissue homeostasis

    Science.gov (United States)

    Nakada, Daisuke; Levi, Boaz P.; Morrison, Sean J.

    2015-01-01

    Summary Stem cells are uniquely able to self-renew, to undergo multilineage differentiation, and to persist throughout life in a number of tissues. Stem cells are regulated by a combination of shared and tissue-specific mechanisms and are distinguished from restricted progenitors by differences in transcriptional and epigenetic regulation. Emerging evidence suggests that other aspects of cellular physiology, including mitosis, signal transduction, and metabolic regulation also differ between stem cells and their progeny. These differences may allow stem cells to be regulated independently of differentiated cells in response to circadian rhythms, changes in metabolism, diet, exercise, mating, aging, infection, and disease. This allows stem cells to sustain homeostasis or to remodel relevant tissues in response to physiological change. Stem cells are therefore not only regulated by short-range signals that maintain homeostasis within their tissue of origin, but also by long-range signals that integrate stem cell function with systemic physiology. PMID:21609826

  11. Social Group Dynamics and Patterns of Latin American Integration Processes

    Directory of Open Access Journals (Sweden)

    Sébastien Dubé

    2017-04-01

    Full Text Available This article proposes to incorporate social psychology elements with mainstream political science and international relations theories to help understand the contradictions related to the integration processes in Latin America. Through a theoretical analysis, it contributes to the challenge proposed by Dabène (2009 to explain the “resilience” of the Latin American regional integration process in spite of its “instability and crises.” Our main proposition calls for considering Latin America as a community and its regional organizations as “social groups.” In conclusion, three phenomena from the field of social psychology and particularly social group dynamics shed light on these contradictory patterns: the value of the group and the emotional bond, groupthink, and cognitive dissonance.

  12. Design and operation of a continuous integrated monoclonal antibody production process.

    Science.gov (United States)

    Steinebach, Fabian; Ulmer, Nicole; Wolf, Moritz; Decker, Lara; Schneider, Veronika; Wälchli, Ruben; Karst, Daniel; Souquet, Jonathan; Morbidelli, Massimo

    2017-09-01

    The realization of an end-to-end integrated continuous lab-scale process for monoclonal antibody manufacturing is described. For this, a continuous cultivation with filter-based cell-retention, a continuous two column capture process, a virus inactivation step, a semi-continuous polishing step (twin-column MCSGP), and a batch-wise flow-through polishing step were integrated and operated together. In each unit, the implementation of internal recycle loops allows to improve the performance: (a) in the bioreactor, to simultaneously increase the cell density and volumetric productivity, (b) in the capture process, to achieve improved capacity utilization at high productivity and yield, and (c) in the MCSGP process, to overcome the purity-yield trade-off of classical batch-wise bind-elute polishing steps. Furthermore, the design principles, which allow the direct connection of these steps, some at steady state and some at cyclic steady state, as well as straight-through processing, are discussed. The setup was operated for the continuous production of a commercial monoclonal antibody, resulting in stable operation and uniform product quality over the 17 cycles of the end-to-end integration. The steady-state operation was fully characterized by analyzing at the outlet of each unit at steady state the product titer as well as the process (HCP, DNA, leached Protein A) and product (aggregates, fragments) related impurities. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 33:1303-1313, 2017. © 2017 American Institute of Chemical Engineers.

  13. Accelerating customer integration into innovation processes using Pico-Jobs

    OpenAIRE

    Blohm, Ivo;Fähling, Jens;Leimeister, Jan Marco;Krcmar, Helmut;Fischer, Jan

    2014-01-01

    Crowdsourcing marketplaces emerged in the internet and enable the integration of customers in various tasks along the innovation process. Marketplaces such as Amazon?s Mechanical Turk install a member base for third parties, where they can offer small, highly structured paid tasks which can hardly be solved automatically with ICT which we call Pico Jobs. In this paper a new method for systematically utilizing the creative potential of the users of these marketplaces for new product developmen...

  14. Materials and Process Design for High-Temperature Carburizing: Integrating Processing and Performance

    Energy Technology Data Exchange (ETDEWEB)

    D. Apelian

    2007-07-23

    The objective of the project is to develop an integrated process for fast, high-temperature carburizing. The new process results in an order of magnitude reduction in cycle time compared to conventional carburizing and represents significant energy savings in addition to a corresponding reduction of scrap associated with distortion free carburizing steels.

  15. A model for optimization of process integration investments under uncertainty

    International Nuclear Information System (INIS)

    Svensson, Elin; Stroemberg, Ann-Brith; Patriksson, Michael

    2011-01-01

    The long-term economic outcome of energy-related industrial investment projects is difficult to evaluate because of uncertain energy market conditions. In this article, a general, multistage, stochastic programming model for the optimization of investments in process integration and industrial energy technologies is proposed. The problem is formulated as a mixed-binary linear programming model where uncertainties are modelled using a scenario-based approach. The objective is to maximize the expected net present value of the investments which enables heat savings and decreased energy imports or increased energy exports at an industrial plant. The proposed modelling approach enables a long-term planning of industrial, energy-related investments through the simultaneous optimization of immediate and later decisions. The stochastic programming approach is also suitable for modelling what is possibly complex process integration constraints. The general model formulation presented here is a suitable basis for more specialized case studies dealing with optimization of investments in energy efficiency. -- Highlights: → Stochastic programming approach to long-term planning of process integration investments. → Extensive mathematical model formulation. → Multi-stage investment decisions and scenario-based modelling of uncertain energy prices. → Results illustrate how investments made now affect later investment and operation opportunities. → Approach for evaluation of robustness with respect to variations in probability distribution.

  16. Ethanol fermentation integrated with PDMS composite membrane: An effective process.

    Science.gov (United States)

    Fu, Chaohui; Cai, Di; Hu, Song; Miao, Qi; Wang, Yong; Qin, Peiyong; Wang, Zheng; Tan, Tianwei

    2016-01-01

    The polydimethylsiloxane (PDMS) membrane, prepared in water phase, was investigated in separation ethanol from model ethanol/water mixture and fermentation-pervaporation integrated process. Results showed that the PDMS membrane could effectively separate ethanol from model solution. When integrated with batch ethanol fermentation, the ethanol productivity was enhanced compared with conventional process. Fed-batch and continuous ethanol fermentation with pervaporation were also performed and studied. 396.2-663.7g/m(2)h and 332.4-548.1g/m(2)h of total flux with separation factor of 8.6-11.7 and 8-11.6, were generated in the fed-batch and continuous fermentation with pervaporation scenario, respectively. At the same time, high titre ethanol production of ∼417.2g/L and ∼446.3g/L were also achieved on the permeate side of membrane in the two scenarios, respectively. The integrated process was environmental friendly and energy saving, and has a promising perspective in long-terms operation. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Impact of informal institutions on the development integration processes

    Directory of Open Access Journals (Sweden)

    Sidorova Alexandra, M.

    2015-06-01

    Full Text Available The paper deals with the impact of informal institutions on the definition of the vector integration processes and the development of integration processes in the countries of the Customs Union and Ukraine. The degree of scientific development of the phenomenon in different economic schools is determined in this article. Economic mentality is a basic informal institutions, which determines the degree of effectiveness of the integration processes. This paper examines the nature, characteristics and effects of economic mentality on the economic activities of people. Ethnometrichal method allows to quantify the economic mentality that enables deeper understanding and analysis of the formation and functioning of political and economic system, especially business and management, establishing contacts with other cultures. It was measured modern Belarusian economic mentality based on international methodology Hofstede and compared with the economic mentality of Russia, Ukraine and Kazakhstan. With the help of cluster analysis congruence economic mentality of the Customs Union and Ukraine was determined. Economic mentality of these countries was also compared with the economic mentality of other countries in order to identify the main types of economic culture.

  18. Collaboration in Global Software Engineering Based on Process Description Integration

    Science.gov (United States)

    Klein, Harald; Rausch, Andreas; Fischer, Edward

    Globalization is one of the big trends in software development. Development projects need a variety of different resources with appropriate expert knowledge to be successful. More and more of these resources are nowadays obtained from specialized organizations and countries all over the world, varying in development approaches, processes, and culture. As seen with early outsourcing attempts, collaboration may fail due to these differences. Hence, the major challenge in global software engineering is to streamline collaborating organizations towards a successful conjoint development. Based on typical collaboration scenarios, this paper presents a structured approach to integrate processes in a comprehensible way.

  19. Integrated Design Process in Problem-Based Learning

    DEFF Research Database (Denmark)

    Knudstrup, Mary-Ann

    2004-01-01

    This article reports and reflects on the learning achievements and the educational experiences in connection with the first years of the curriculum in Architecture at Aalborg University ?s Civil Engineer Education in Architecture & Design. In the article I will focus on the learning activity and ...... the students need in order to concentrate, mobilize creativity and find the personal design language which is a precondition for making good architecture....... and the method that are developed during the semester when working with an Integrated Design Process combining architecture, design, functional aspects, energy consumption, indoor environment, technology, and construction. I will emphasize the importance of working with different tools in the design process, e...

  20. Integrating chemical engineering fundamentals in the capstone process design project

    DEFF Research Database (Denmark)

    von Solms, Nicolas; Woodley, John; Johnsson, Jan Erik

    2010-01-01

    Reaction Engineering. In order to incorporate reactor design into process design in a meaningful way, the teachers of the respective courses need to collaborate (Standard 9 – Enhancement of Faculty CDIO skills). The students also see that different components of the chemical engineering curriculum relate......All B.Eng. courses offered at the Technical University of Denmark (DTU) must now follow CDIO standards. The final “capstone” course in the B.Eng. education is Process Design, which for many years has been typical of chemical engineering curricula worldwide. The course at DTU typically has about 30...... of the CDIO standards – especially standard 3 – Integrated Curriculum - means that the course projects must draw on competences provided in other subjects which the students are taking in parallel with Process Design – specifically Process Control and Reaction Engineering. In each semester of the B...

  1. Adaptive Moving Object Tracking Integrating Neural Networks And Intelligent Processing

    Science.gov (United States)

    Lee, James S. J.; Nguyen, Dziem D.; Lin, C.

    1989-03-01

    A real-time adaptive scheme is introduced to detect and track moving objects under noisy, dynamic conditions including moving sensors. This approach integrates the adaptiveness and incremental learning characteristics of neural networks with intelligent reasoning and process control. Spatiotemporal filtering is used to detect and analyze motion, exploiting the speed and accuracy of multiresolution processing. A neural network algorithm constitutes the basic computational structure for classification. A recognition and learning controller guides the on-line training of the network, and invokes pattern recognition to determine processing parameters dynamically and to verify detection results. A tracking controller acts as the central control unit, so that tracking goals direct the over-all system. Performance is benchmarked against the Widrow-Hoff algorithm, for target detection scenarios presented in diverse FLIR image sequences. Efficient algorithm design ensures that this recognition and control scheme, implemented in software and commercially available image processing hardware, meets the real-time requirements of tracking applications.

  2. Integrating Process Management with Archival Management Systems: Lessons Learned

    Directory of Open Access Journals (Sweden)

    J. Gordon Daines, III

    2009-03-01

    Full Text Available The Integrated Digital Special Collections (INDI system is a prototype of a database-driven, Web application designed to automate and manage archival workflow for large institutions and consortia. This article discusses the how the INDI project enabled the successful implementation of a process to manage large technology projects in the Harold B. Lee Library at Brigham Young University. It highlights how the scope of these technology projects is set and how the major deliverables for each project are defined. The article also talks about how the INDI system followed the process and still failed to be completed. It examines why the process itself is successful and why the INDI project failed. It further underscores the importance of process management in archival management systems.

  3. Detection of a novel, integrative aging process suggests complex physiological integration.

    Science.gov (United States)

    Cohen, Alan A; Milot, Emmanuel; Li, Qing; Bergeron, Patrick; Poirier, Roxane; Dusseault-Bélanger, Francis; Fülöp, Tamàs; Leroux, Maxime; Legault, Véronique; Metter, E Jeffrey; Fried, Linda P; Ferrucci, Luigi

    2015-01-01

    Many studies of aging examine biomarkers one at a time, but complex systems theory and network theory suggest that interpretations of individual markers may be context-dependent. Here, we attempted to detect underlying processes governing the levels of many biomarkers simultaneously by applying principal components analysis to 43 common clinical biomarkers measured longitudinally in 3694 humans from three longitudinal cohort studies on two continents (Women's Health and Aging I & II, InCHIANTI, and the Baltimore Longitudinal Study on Aging). The first axis was associated with anemia, inflammation, and low levels of calcium and albumin. The axis structure was precisely reproduced in all three populations and in all demographic sub-populations (by sex, race, etc.); we call the process represented by the axis "integrated albunemia." Integrated albunemia increases and accelerates with age in all populations, and predicts mortality and frailty--but not chronic disease--even after controlling for age. This suggests a role in the aging process, though causality is not yet clear. Integrated albunemia behaves more stably across populations than its component biomarkers, and thus appears to represent a higher-order physiological process emerging from the structure of underlying regulatory networks. If this is correct, detection of this process has substantial implications for physiological organization more generally.

  4. Detection of a novel, integrative aging process suggests complex physiological integration.

    Directory of Open Access Journals (Sweden)

    Alan A Cohen

    Full Text Available Many studies of aging examine biomarkers one at a time, but complex systems theory and network theory suggest that interpretations of individual markers may be context-dependent. Here, we attempted to detect underlying processes governing the levels of many biomarkers simultaneously by applying principal components analysis to 43 common clinical biomarkers measured longitudinally in 3694 humans from three longitudinal cohort studies on two continents (Women's Health and Aging I & II, InCHIANTI, and the Baltimore Longitudinal Study on Aging. The first axis was associated with anemia, inflammation, and low levels of calcium and albumin. The axis structure was precisely reproduced in all three populations and in all demographic sub-populations (by sex, race, etc.; we call the process represented by the axis "integrated albunemia." Integrated albunemia increases and accelerates with age in all populations, and predicts mortality and frailty--but not chronic disease--even after controlling for age. This suggests a role in the aging process, though causality is not yet clear. Integrated albunemia behaves more stably across populations than its component biomarkers, and thus appears to represent a higher-order physiological process emerging from the structure of underlying regulatory networks. If this is correct, detection of this process has substantial implications for physiological organization more generally.

  5. Integrating cell biology and proteomic approaches in plants.

    Science.gov (United States)

    Takáč, Tomáš; Šamajová, Olga; Šamaj, Jozef

    2017-10-03

    Significant improvements of protein extraction, separation, mass spectrometry and bioinformatics nurtured advancements of proteomics during the past years. The usefulness of proteomics in the investigation of biological problems can be enhanced by integration with other experimental methods from cell biology, genetics, biochemistry, pharmacology, molecular biology and other omics approaches including transcriptomics and metabolomics. This review aims to summarize current trends integrating cell biology and proteomics in plant science. Cell biology approaches are most frequently used in proteomic studies investigating subcellular and developmental proteomes, however, they were also employed in proteomic studies exploring abiotic and biotic stress responses, vesicular transport, cytoskeleton and protein posttranslational modifications. They are used either for detailed cellular or ultrastructural characterization of the object subjected to proteomic study, validation of proteomic results or to expand proteomic data. In this respect, a broad spectrum of methods is employed to support proteomic studies including ultrastructural electron microscopy studies, histochemical staining, immunochemical localization, in vivo imaging of fluorescently tagged proteins and visualization of protein-protein interactions. Thus, cell biological observations on fixed or living cell compartments, cells, tissues and organs are feasible, and in some cases fundamental for the validation and complementation of proteomic data. Validation of proteomic data by independent experimental methods requires development of new complementary approaches. Benefits of cell biology methods and techniques are not sufficiently highlighted in current proteomic studies. This encouraged us to review most popular cell biology methods used in proteomic studies and to evaluate their relevance and potential for proteomic data validation and enrichment of purely proteomic analyses. We also provide examples of

  6. Flexible PCPDTBT:PCBM solar cells with integrated grating structures

    DEFF Research Database (Denmark)

    Oliveira Hansen, Roana Melina de; Liu, Yinghui; Madsen, Morten

    2013-01-01

    We report on development of flexible PCPDTBT:PCBM solar cells with integrated diffraction gratings on the bottom electrodes. The presented results address PCPDTBT:PCBM solar cells in an inverted geometry, which contains implemented grating structures whose pitch is tuned to match the absorption...... spectra of the active layer. This optimized solar cell structure leads to an enhanced absorption in the active layer and thus improved short-circuit currents and power conversion efficiencies in the fabricated devices. Fabrication of the solar cells on thin polyimide substrates which are compatible...

  7. Ethanol production in an integrated fermentation/membrane system. Process simulations and economics

    Energy Technology Data Exchange (ETDEWEB)

    Groot, W J; Kraayenbrink, M R; Lans, R.G.J.M. van der; Luyben, K C.A.M. [Delft Univ. of Technology (Netherlands). Dept. of Biochemical Engineering

    1993-01-01

    Four systems comprising of an ethanol fermentation integrated with microfiltration and/or pervaporation, and a conventional continuous culture, were compared with respect to the performance of the fermentation and economics. The processes are compared on the basis of the same kinetic model. It is found that cell retention by microfiltration leads to lower production costs, compared to a conventional continuous culture. Pervaporation becomes profitable at a high selectivity of ethanol/water separation and low membrane prices. (orig.).

  8. CD4 T cell autophagy is integral to memory maintenance.

    Science.gov (United States)

    Murera, Diane; Arbogast, Florent; Arnold, Johan; Bouis, Delphine; Muller, Sylviane; Gros, Frédéric

    2018-04-13

    Studies of mice deficient for autophagy in T cells since thymic development, concluded that autophagy is integral to mature T cell homeostasis. Basal survival and functional impairments in vivo, limited the use of these models to delineate the role of autophagy during the immune response. We generated Atg5 f/f distal Lck (dLck)-cre mice, with deletion of autophagy only at a mature stage. In this model, autophagy deficiency impacts CD8 + T cell survival but has no influence on CD4 + T cell number and short-term activation. Moreover, autophagy in T cells is dispensable during early humoral response but critical for long-term antibody production. Autophagy in CD4 + T cells is required to transfer humoral memory as shown by injection of antigen-experienced cells in naive mice. We also observed a selection of autophagy-competent cells in the CD4 + T cell memory compartment. We performed in vitro differentiation of memory CD4 + T cells, to better characterize autophagy-deficient memory cells. We identified mitochondrial and lipid load defects in differentiated memory CD4 + T cells, together with a compromised survival, without any collapse of energy production. We then propose that memory CD4 + T cells rely on autophagy for their survival to regulate toxic effects of mitochondrial activity and lipid overload.

  9. Managing processes and information technology in mergers - the integration of finance processes and systems

    OpenAIRE

    Pedain, Christoph

    2003-01-01

    Many companies use mergers to achieve their growth goals or target technology position. To realise synergies that justify the merger transaction, an integration of the merged companies is often necessary. Such integartion takes place across company business areas (such as finance or sales) and across the layers of management consideration, which are strategy, human resources, organisation, processes, and information technology. In merger integration techniques, there is a significant gap ...

  10. Process modeling for the Integrated Thermal Treatment System (ITTS) study

    Energy Technology Data Exchange (ETDEWEB)

    Liebelt, K.H.; Brown, B.W.; Quapp, W.J.

    1995-09-01

    This report describes the process modeling done in support of the integrated thermal treatment system (ITTS) study, Phases 1 and 2. ITTS consists of an integrated systems engineering approach for uniform comparison of widely varying thermal treatment technologies proposed for treatment of the contact-handled mixed low-level wastes (MLLW) currently stored in the U.S. Department of Energy complex. In the overall study, 19 systems were evaluated. Preconceptual designs were developed that included all of the various subsystems necessary for a complete installation, from waste receiving through to primary and secondary stabilization and disposal of the processed wastes. Each system included the necessary auxiliary treatment subsystems so that all of the waste categories in the complex were fully processed. The objective of the modeling task was to perform mass and energy balances of the major material components in each system. Modeling of trace materials, such as pollutants and radioactive isotopes, were beyond the present scope. The modeling of the main and secondary thermal treatment, air pollution control, and metal melting subsystems was done using the ASPEN PLUS process simulation code, Version 9.1-3. These results were combined with calculations for the remainder of the subsystems to achieve the final results, which included offgas volumes, and mass and volume waste reduction ratios.

  11. Process modeling for the Integrated Thermal Treatment System (ITTS) study

    International Nuclear Information System (INIS)

    Liebelt, K.H.; Brown, B.W.; Quapp, W.J.

    1995-09-01

    This report describes the process modeling done in support of the integrated thermal treatment system (ITTS) study, Phases 1 and 2. ITTS consists of an integrated systems engineering approach for uniform comparison of widely varying thermal treatment technologies proposed for treatment of the contact-handled mixed low-level wastes (MLLW) currently stored in the U.S. Department of Energy complex. In the overall study, 19 systems were evaluated. Preconceptual designs were developed that included all of the various subsystems necessary for a complete installation, from waste receiving through to primary and secondary stabilization and disposal of the processed wastes. Each system included the necessary auxiliary treatment subsystems so that all of the waste categories in the complex were fully processed. The objective of the modeling task was to perform mass and energy balances of the major material components in each system. Modeling of trace materials, such as pollutants and radioactive isotopes, were beyond the present scope. The modeling of the main and secondary thermal treatment, air pollution control, and metal melting subsystems was done using the ASPEN PLUS process simulation code, Version 9.1-3. These results were combined with calculations for the remainder of the subsystems to achieve the final results, which included offgas volumes, and mass and volume waste reduction ratios

  12. Integrated safeguards and security for a highly automated process

    International Nuclear Information System (INIS)

    Zack, N.R.; Hunteman, W.J.; Jaeger, C.D.

    1993-01-01

    Before the cancellation of the New Production Reactor Programs for the production of tritium, the reactors and associated processing were being designed to contain some of the most highly automated and remote systems conceived for a Department of Energy facility. Integrating safety, security, materials control and accountability (MC and A), and process systems at the proposed facilities would enhance the overall information and protection-in-depth available. Remote, automated fuel handling and assembly/disassembly techniques would deny access to the nuclear materials while upholding ALARA principles but would also require the full integration of all data/information systems. Such systems would greatly enhance MC and A as well as facilitate materials tracking. Physical protection systems would be connected with materials control features to cross check activities and help detect and resolve anomalies. This paper will discuss the results of a study of the safeguards and security benefits achieved from a highly automated and integrated remote nuclear facility and the impacts that such systems have on safeguards and computer and information security

  13. The process flow and structure of an integrated stroke strategy

    Directory of Open Access Journals (Sweden)

    Emma F. van Bussel

    2013-06-01

    Full Text Available Introduction: In the Canadian province of Alberta access and quality of stroke care were suboptimal, especially in remote areas. The government introduced the Alberta Provincial Stroke Strategy (APSS in 2005, an integrated strategy to improve access to stroke care, quality and efficiency which utilizes telehealth. Research question: What is the process flow and the structure of the care pathways of the APSS? Methodology: Information for this article was obtained using documentation, archival APSS records, interviews with experts, direct observation and participant observation. Results: The process flow is described. The APSS integrated evidence-based practice, multidisciplinary communication, and telestroke services. It includes regular quality evaluation and improvement. Conclusion: Access, efficiency and quality of care improved since the start of the APSS across many domains, through improvement of expertise and equipment in small hospitals, accessible consultation of stroke specialists using telestroke, enhancing preventive care, enhancing multidisciplinary collaboration, introducing uniform best practice protocols and bypass-protocols for the emergency medical services. Discussion: The APSS overcame substantial obstacles to decrease discrepancies and to deliver integrated higher quality care. Telestroke has proven itself to be safe and feasible. The APSS works efficiently, which is in line to other projects worldwide, and is, based on limited results, cost effective. Further research on cost-effectiveness is necessary.

  14. Transactivation domain of p53 regulates DNA repair and integrity in human iPS cells.

    Science.gov (United States)

    Kannappan, Ramaswamy; Mattapally, Saidulu; Wagle, Pooja A; Zhang, Jianyi

    2018-05-18

    The role of p53 transactivation domain (p53-TAD), a multifunctional and dynamic domain, on DNA repair and retaining DNA integrity in human iPS cells has never been studied. p53-TAD was knocked out in iPS cells using CRISPR/Cas9 and was confirmed by DNA sequencing. p53-TAD KO cells were characterized by: accelerated proliferation, decreased population doubling time, and unaltered Bcl2, BBC3, IGF1R, Bax and altered Mdm2, p21, and PIDD transcripts expression. In p53-TAD KO cells p53 regulated DNA repair proteins XPA, DNA polH and DDB2 expression were found to be reduced compared to p53-WT cells. Exposure to low dose of doxorubicin (Doxo) induced similar DNA damage and DNA damage response (DDR) measured by RAD50 and MRE11 expression, Checkpoint kinase 2 activation and γH2A.X recruitment at DNA strand breaks in both the cell groups indicating silencing p53-TAD do not affect DDR mechanism upstream of p53. Following removal of Doxo p53-WT hiPS cells underwent DNA repair, corrected their damaged DNA and restored DNA integrity. Conversely, p53-TAD KO hiPS cells did not undergo complete DNA repair and failed to restore DNA integrity. More importantly continuous culture of p53-TAD KO hiPS cells underwent G2/M cell cycle arrest and expressed cellular senescent marker p16 INK4a . Our data clearly shows that silencing transactivation domain of p53 did not affect DDR but affected the DNA repair process implying the crucial role of p53 transactivation domain in maintaining DNA integrity. Therefore, activating p53-TAD domain using small molecules may promote DNA repair and integrity of cells and prevent senescence.

  15. Integrating protein engineering with process design for biocatalysis

    DEFF Research Database (Denmark)

    Woodley, John M.

    2017-01-01

    Biocatalysis uses enzymes for chemical synthesis and production, offering selective, safe and sustainable catalysis. While today the majority of applications are in the pharmaceutical sector, new opportunities are arising every day in other industry sectors, where production costs become a more...... important driver. In the early applications of the technology, it was necessary to design processes to match the properties of the biocatalyst. With the advent of protein engineering, organic chemists started to develop and improve enzymes to suit their needs. Likewise in industry, although not widespread......, a new paradigm was already implemented several years ago to engineer enzymes to suit process needs. Today, a new era is entered, where the effectiveness with which such integrated protein and process engineering is achieved becomes critical to implementation. In this paper, the development of a tool...

  16. Process integrated modelling for steelmaking Life Cycle Inventory analysis

    International Nuclear Information System (INIS)

    Iosif, Ana-Maria; Hanrot, Francois; Ablitzer, Denis

    2008-01-01

    During recent years, strict environmental regulations have been implemented by governments for the steelmaking industry in order to reduce their environmental impact. In the frame of the ULCOS project, we have developed a new methodological framework which combines the process integrated modelling approach with Life Cycle Assessment (LCA) method in order to carry out the Life Cycle Inventory of steelmaking. In the current paper, this new concept has been applied to the sinter plant which is the most polluting steelmaking process. It has been shown that this approach is a powerful tool to make the collection of data easier, to save time and to provide reliable information concerning the environmental diagnostic of the steelmaking processes

  17. Barriers and Challenges in the Integrated Design Process Approcach

    DEFF Research Database (Denmark)

    Knudstrup, Mary-Ann

    2006-01-01

    ABSTRACT: In the future, it will be a huge challenge to make sustainable building design by using a more holistic and innovative approach in order to be able to decrease or reduce the use of energy for heating and cooling in new building projects. This is seen in the perspective of the Kyoto agre....... It also describes the barriers and the challenges that must be overcome when trying to cross the borders between the two fields of engineering and architecture to design sustainable architecture....... agreement for reducing the global heating. This paper will briefly present the method of the Integrated Design Process, IDP [1]. It describes the background and means for developing a new method for designing integrated architecture in an interdisciplinary approach between architecture and engineering...

  18. Analog integrated circuits design for processing physiological signals.

    Science.gov (United States)

    Li, Yan; Poon, Carmen C Y; Zhang, Yuan-Ting

    2010-01-01

    Analog integrated circuits (ICs) designed for processing physiological signals are important building blocks of wearable and implantable medical devices used for health monitoring or restoring lost body functions. Due to the nature of physiological signals and the corresponding application scenarios, the ICs designed for these applications should have low power consumption, low cutoff frequency, and low input-referred noise. In this paper, techniques for designing the analog front-end circuits with these three characteristics will be reviewed, including subthreshold circuits, bulk-driven MOSFETs, floating gate MOSFETs, and log-domain circuits to reduce power consumption; methods for designing fully integrated low cutoff frequency circuits; as well as chopper stabilization (CHS) and other techniques that can be used to achieve a high signal-to-noise performance. Novel applications using these techniques will also be discussed.

  19. On-chip enzymatic microbiofuel cell-powered integrated circuits.

    Science.gov (United States)

    Mark, Andrew G; Suraniti, Emmanuel; Roche, Jérôme; Richter, Harald; Kuhn, Alexander; Mano, Nicolas; Fischer, Peer

    2017-05-16

    A variety of diagnostic and therapeutic medical technologies rely on long term implantation of an electronic device to monitor or regulate a patient's condition. One proposed approach to powering these devices is to use a biofuel cell to convert the chemical energy from blood nutrients into electrical current to supply the electronics. We present here an enzymatic microbiofuel cell whose electrodes are directly integrated into a digital electronic circuit. Glucose oxidizing and oxygen reducing enzymes are immobilized on microelectrodes of an application specific integrated circuit (ASIC) using redox hydrogels to produce an enzymatic biofuel cell, capable of harvesting electrical power from just a single droplet of 5 mM glucose solution. Optimisation of the fuel cell voltage and power to match the requirements of the electronics allow self-powered operation of the on-board digital circuitry. This study represents a step towards implantable self-powered electronic devices that gather their energy from physiological fluids.

  20. Cellular Decision Making by Non-Integrative Processing of TLR Inputs

    Directory of Open Access Journals (Sweden)

    Ryan A. Kellogg

    2017-04-01

    Full Text Available Cells receive a multitude of signals from the environment, but how they process simultaneous signaling inputs is not well understood. Response to infection, for example, involves parallel activation of multiple Toll-like receptors (TLRs that converge on the nuclear factor κB (NF-κB pathway. Although we increasingly understand inflammatory responses for isolated signals, it is not clear how cells process multiple signals that co-occur in physiological settings. We therefore examined a bacterial infection scenario involving co-stimulation of TLR4 and TLR2. Independent stimulation of these receptors induced distinct NF-κB dynamic profiles, although surprisingly, under co-stimulation, single cells continued to show ligand-specific dynamic responses characteristic of TLR2 or TLR4 signaling rather than a mixed response, comprising a cellular decision that we term “non-integrative” processing. Iterating modeling and microfluidic experiments revealed that non-integrative processing occurred through interaction of switch-like NF-κB activation, receptor-specific processing timescales, cell-to-cell variability, and TLR cross-tolerance mediated by multilayer negative feedback.

  1. Integration of Solar Cells on Top of CMOS Chips Part I: a-Si Solar Cells

    NARCIS (Netherlands)

    Lu, J.; Kovalgin, Alexeij Y.; van der Werf, Karine H.M.; Schropp, Ruud E.I.; Schmitz, Jurriaan

    2011-01-01

    We present the monolithic integration of deepsubmicrometer complementary metal–oxide–semiconductor (CMOS) microchips with a-Si:H solar cells. Solar cells are manufactured directly on the CMOS chips. The microchips maintain comparable electronic performance, and the solar cells show efficiency values

  2. A data integration approach for cell cycle analysis oriented to model simulation in systems biology

    Directory of Open Access Journals (Sweden)

    Mosca Ettore

    2007-08-01

    Full Text Available Abstract Background The cell cycle is one of the biological processes most frequently investigated in systems biology studies and it involves the knowledge of a large number of genes and networks of protein interactions. A deep knowledge of the molecular aspect of this biological process can contribute to making cancer research more accurate and innovative. In this context the mathematical modelling of the cell cycle has a relevant role to quantify the behaviour of each component of the systems. The mathematical modelling of a biological process such as the cell cycle allows a systemic description that helps to highlight some features such as emergent properties which could be hidden when the analysis is performed only from a reductionism point of view. Moreover, in modelling complex systems, a complete annotation of all the components is equally important to understand the interaction mechanism inside the network: for this reason data integration of the model components has high relevance in systems biology studies. Description In this work, we present a resource, the Cell Cycle Database, intended to support systems biology analysis on the Cell Cycle process, based on two organisms, yeast and mammalian. The database integrates information about genes and proteins involved in the cell cycle process, stores complete models of the interaction networks and allows the mathematical simulation over time of the quantitative behaviour of each component. To accomplish this task, we developed, a web interface for browsing information related to cell cycle genes, proteins and mathematical models. In this framework, we have implemented a pipeline which allows users to deal with the mathematical part of the models, in order to solve, using different variables, the ordinary differential equation systems that describe the biological process. Conclusion This integrated system is freely available in order to support systems biology research on the cell cycle and

  3. Moral judgment as information processing: an integrative review.

    Science.gov (United States)

    Guglielmo, Steve

    2015-01-01

    How do humans make moral judgments about others' behavior? This article reviews dominant models of moral judgment, organizing them within an overarching framework of information processing. This framework poses two distinct questions: (1) What input information guides moral judgments? and (2) What psychological processes generate these judgments? Information Models address the first question, identifying critical information elements (including causality, intentionality, and mental states) that shape moral judgments. A subclass of Biased Information Models holds that perceptions of these information elements are themselves driven by prior moral judgments. Processing Models address the second question, and existing models have focused on the relative contribution of intuitive versus deliberative processes. This review organizes existing moral judgment models within this framework and critically evaluates them on empirical and theoretical grounds; it then outlines a general integrative model grounded in information processing, and concludes with conceptual and methodological suggestions for future research. The information-processing framework provides a useful theoretical lens through which to organize extant and future work in the rapidly growing field of moral judgment.

  4. Moral judgment as information processing: an integrative review

    Science.gov (United States)

    Guglielmo, Steve

    2015-01-01

    How do humans make moral judgments about others’ behavior? This article reviews dominant models of moral judgment, organizing them within an overarching framework of information processing. This framework poses two distinct questions: (1) What input information guides moral judgments? and (2) What psychological processes generate these judgments? Information Models address the first question, identifying critical information elements (including causality, intentionality, and mental states) that shape moral judgments. A subclass of Biased Information Models holds that perceptions of these information elements are themselves driven by prior moral judgments. Processing Models address the second question, and existing models have focused on the relative contribution of intuitive versus deliberative processes. This review organizes existing moral judgment models within this framework and critically evaluates them on empirical and theoretical grounds; it then outlines a general integrative model grounded in information processing, and concludes with conceptual and methodological suggestions for future research. The information-processing framework provides a useful theoretical lens through which to organize extant and future work in the rapidly growing field of moral judgment. PMID:26579022

  5. [The dual process model of addiction. Towards an integrated model?].

    Science.gov (United States)

    Vandermeeren, R; Hebbrecht, M

    2012-01-01

    Neurobiology and cognitive psychology have provided us with a dual process model of addiction. According to this model, behavior is considered to be the dynamic result of a combination of automatic and controlling processes. In cases of addiction the balance between these two processes is severely disturbed. Automated processes will continue to produce impulses that ensure the continuance of addictive behavior. Weak, reflective or controlling processes are both the reason for and the result of the inability to forgo addiction. To identify features that are common to current neurocognitive insights into addiction and psychodynamic views on addiction. The picture that emerges from research is not clear. There is some evidence that attentional bias has a causal effect on addiction. There is no evidence that automatic associations have a causal effect, but there is some evidence that automatic action-tendencies do have a causal effect. Current neurocognitive views on the dual process model of addiction can be integrated with an evidence-based approach to addiction and with psychodynamic views on addiction.

  6. Integrable Floquet dynamics, generalized exclusion processes and "fused" matrix ansatz

    Science.gov (United States)

    Vanicat, Matthieu

    2018-04-01

    We present a general method for constructing integrable stochastic processes, with two-step discrete time Floquet dynamics, from the transfer matrix formalism. The models can be interpreted as a discrete time parallel update. The method can be applied for both periodic and open boundary conditions. We also show how the stationary distribution can be built as a matrix product state. As an illustration we construct parallel discrete time dynamics associated with the R-matrix of the SSEP and of the ASEP, and provide the associated stationary distributions in a matrix product form. We use this general framework to introduce new integrable generalized exclusion processes, where a fixed number of particles is allowed on each lattice site in opposition to the (single particle) exclusion process models. They are constructed using the fusion procedure of R-matrices (and K-matrices for open boundary conditions) for the SSEP and ASEP. We develop a new method, that we named "fused" matrix ansatz, to build explicitly the stationary distribution in a matrix product form. We use this algebraic structure to compute physical observables such as the correlation functions and the mean particle current.

  7. Dielectrophoretic focusing integrated pulsed laser activated cell sorting

    Science.gov (United States)

    Zhu, Xiongfeng; Kung, Yu-Chun; Wu, Ting-Hsiang; Teitell, Michael A.; Chiou, Pei-Yu

    2017-08-01

    We present a pulsed laser activated cell sorter (PLACS) integrated with novel sheathless size-independent dielectrophoretic (DEP) focusing. Microfluidic fluorescence activated cell sorting (μFACS) systems aim to provide a fully enclosed environment for sterile cell sorting and integration with upstream and downstream microfluidic modules. Among them, PLACS has shown a great potential in achieving comparable performance to commercial aerosol-based FACS (>90% purity at 25,000 cells sec-1). However conventional sheath flow focusing method suffers a severe sample dilution issue. Here we demonstrate a novel dielectrophoresis-integrated pulsed laser activated cell sorter (DEP-PLACS). It consists of a microfluidic channel with 3D electrodes laid out to provide a tunnel-shaped electric field profile along a 4cmlong channel for sheathlessly focusing microparticles/cells into a single stream in high-speed microfluidic flows. All focused particles pass through the fluorescence detection zone along the same streamline regardless of their sizes and types. Upon detection of target fluorescent particles, a nanosecond laser pulse is triggered and focused in a neighboring channel to generate a rapidly expanding cavitation bubble for precise sorting. DEP-PLACS has achieved a sorting purity of 91% for polystyrene beads at a throughput of 1,500 particle/sec.

  8. Small-scale integrated demonstration of high-level radioactive waste processing and vitrification using actual SRP waste

    International Nuclear Information System (INIS)

    Woolsey, G.B.; Baumgarten, P.K.; Eibling, R.E.; Ferguson, R.B.

    1981-01-01

    A small-scale pilot plant for chemical processing and vitrification of actual high-level waste has been constructed at the Savannah River Laboratory (SRL). This fully integrated facility has been constructed in six shielded cells and has eight major unit operations. Equipment performance and processing characteristics of the unit operations are reported

  9. On-chip integrated labelling, transport and detection of tumour cells.

    Science.gov (United States)

    Woods, Jane; Docker, Peter T; Dyer, Charlotte E; Haswell, Stephen J; Greenman, John

    2011-11-01

    Microflow cytometry represents a promising tool for the investigation of diagnostic and prognostic cellular cancer markers, particularly if integrated within a device that allows primary cells to be freshly isolated from the solid tumour biopsies that more accurately reflect patient-specific in vivo tissue microenvironments at the time of staining. However, current tissue processing techniques involve several sequential stages with concomitant cell losses, and as such are inappropriate for use with small biopsies. Accordingly, we present a simple method for combined antibody-labelling and dissociation of heterogeneous cells from a tumour mass, which reduces the number of processing steps. Perfusion of ex vivo tissue at 4°C with antibodies and enzymes slows cellular activity while allowing sufficient time for the diffusion of minimally active enzymes. In situ antibody-labelled cells are then dissociated at 37°C from the tumour mass, whereupon hydrogel-filled channels allow the release of relatively low cell numbers (<1000) into a biomimetic microenvironment. This novel approach to sample processing is then further integrated with hydrogel-based electrokinetic transport of the freshly liberated fluorescent cells for downstream detection. It is anticipated that this integrated microfluidic methodology will have wide-ranging biomedical and clinical applications. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Westinghouse integrated cementation facility. Smart process automation minimizing secondary waste

    International Nuclear Information System (INIS)

    Fehrmann, H.; Jacobs, T.; Aign, J.

    2015-01-01

    The Westinghouse Cementation Facility described in this paper is an example for a typical standardized turnkey project in the area of waste management. The facility is able to handle NPP waste such as evaporator concentrates, spent resins and filter cartridges. The facility scope covers all equipment required for a fully integrated system including all required auxiliary equipment for hydraulic, pneumatic and electric control system. The control system is based on actual PLC technology and the process is highly automated. The equipment is designed to be remotely operated, under radiation exposure conditions. 4 cementation facilities have been built for new CPR-1000 nuclear power stations in China

  11. Integration of e-learning outcomes into work processes

    OpenAIRE

    Kerstin Grundén

    2011-01-01

    Three case studies of in-house developed e-learning education in public organizations with different pedagogical approaches are used as a starting point for discussion regarding the implementation challenges of e-learning at work. The aim of this article is to contribute to the understanding of integrating mechanisms of e-learning outcomes into work processes in large, public organizations. The case studies were analyzed from a socio-cultural perspective using the MOA-model as a frame of refe...

  12. Integration of social networks in the teaching and learning process

    Directory of Open Access Journals (Sweden)

    Cynthia Dedós Reyes

    2015-09-01

    Full Text Available In this research we explored the integration of social media in the process of learning and teaching, in a private higher education institution, in Puerto Rico. Attention was given to the perspectives of teachers and students. The participants —9 part-time teachers and 118 students— were selected based on availability. The results showed that teachers and students alike use social the network You Tube for academic purposes; and use Facebook, Twitter, and blogs for social purposes and entertainment. Results also revealed that there is no significant contrast between the perspectives of teachers and students digital immigrants.

  13. A generalized integral fluctuation theorem for general jump processes

    International Nuclear Information System (INIS)

    Liu Fei; Ouyang Zhongcan; Luo Yupin; Huang Mingchang

    2009-01-01

    Using the Feynman-Kac and Cameron-Martin-Girsanov formulae, we obtain a generalized integral fluctuation theorem (GIFT) for discrete jump processes by constructing a time-invariable inner product. The existing discrete IFTs can be derived as its specific cases. A connection between our approach and the conventional time-reversal method is also established. Unlike the latter approach that has been extensively employed in the existing literature, our approach can naturally bring out the definition of a time reversal of a Markovian stochastic system. Additionally, we find that the robust GIFT usually does not result in a detailed fluctuation theorem. (fast track communication)

  14. An integrated biotechnology platform for developing sustainable chemical processes.

    Science.gov (United States)

    Barton, Nelson R; Burgard, Anthony P; Burk, Mark J; Crater, Jason S; Osterhout, Robin E; Pharkya, Priti; Steer, Brian A; Sun, Jun; Trawick, John D; Van Dien, Stephen J; Yang, Tae Hoon; Yim, Harry

    2015-03-01

    Genomatica has established an integrated computational/experimental metabolic engineering platform to design, create, and optimize novel high performance organisms and bioprocesses. Here we present our platform and its use to develop E. coli strains for production of the industrial chemical 1,4-butanediol (BDO) from sugars. A series of examples are given to demonstrate how a rational approach to strain engineering, including carefully designed diagnostic experiments, provided critical insights about pathway bottlenecks, byproducts, expression balancing, and commercial robustness, leading to a superior BDO production strain and process.

  15. Integrated continuous processing of proteins expressed as inclusion bodies: GCSF as a case study.

    Science.gov (United States)

    Kateja, Nikhil; Agarwal, Harshit; Hebbi, Vishwanath; Rathore, Anurag S

    2017-07-01

    Affordability of biopharmaceuticals continues to be a challenge, particularly in developing economies. This has fuelled advancements in manufacturing that can offer higher productivity and better economics without sacrificing product quality in the form of an integrated continuous manufacturing platform. While platform processes for monoclonal antibodies have existed for more than a decade, development of an integrated continuous manufacturing process for bacterial proteins has received relatively scant attention. In this study, we propose an end-to-end integrated continuous downstream process (from inclusion bodies to unformulated drug substance) for a therapeutic protein expressed in Escherichia coli as inclusion body. The final process consisted of a continuous refolding in a coiled flow inverter reactor directly coupled to a three-column periodic counter-current chromatography for capture of the product followed by a three-column con-current chromatography for polishing. The continuous bioprocessing train was run uninterrupted for 26 h to demonstrate its capability and the resulting output was analyzed for the various critical quality attributes, namely product purity (>99%), high molecular weight impurities (<0.5%), host cell proteins (<100 ppm), and host cell DNA (<10 ppb). All attributes were found to be consistent over the period of operation. The developed assembly offers smaller facility footprint, higher productivity, fewer hold steps, and significantly higher equipment and resin utilization. The complexities of process integration in the context of continuous processing have been highlighted. We hope that the study presented here will promote development of highly efficient, universal, end-to-end, fully continuous platforms for manufacturing of biotherapeutics. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 33:998-1009, 2017. © 2016 American Institute of Chemical Engineers.

  16. Biodiesel production process from microalgae oil by waste heat recovery and process integration.

    Science.gov (United States)

    Song, Chunfeng; Chen, Guanyi; Ji, Na; Liu, Qingling; Kansha, Yasuki; Tsutsumi, Atsushi

    2015-10-01

    In this work, the optimization of microalgae oil (MO) based biodiesel production process is carried out by waste heat recovery and process integration. The exergy analysis of each heat exchanger presented an efficient heat coupling between hot and cold streams, thus minimizing the total exergy destruction. Simulation results showed that the unit production cost of optimized process is 0.592$/L biodiesel, and approximately 0.172$/L biodiesel can be avoided by heat integration. Although the capital cost of the optimized biodiesel production process increased 32.5% and 23.5% compared to the reference cases, the operational cost can be reduced by approximately 22.5% and 41.6%. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Integrating Wind And Solar With Hydrogen Producing Fuel Cells

    NARCIS (Netherlands)

    Hemmes, K.

    2007-01-01

    The often proposed solution for the fluctuating wind energy supply is the conversion of the surplus of wind energy into hydrogen by means of electrolysis. In this paper a patented alternative is proposed consisting of the integration of wind turbines with internal reforming fuel-cells, capable of

  18. A Miniaturized Optical Sensor with Integrated Gas Cell

    NARCIS (Netherlands)

    Ayerden, N.P.; Ghaderi, M.; De Graaf, G.; Wolffenbuttel, R.F.

    2015-01-01

    The design, fabrication and characterization of a highly integrated optical gas sensor is presented. The gas cell takes up most of the space in a microspectrometer and is the only component that has so far not been miniaturized. Using the tapered resonator cavity of a linear variable optical filter

  19. Integral reactor system and method for fuel cells

    Science.gov (United States)

    Fernandes, Neil Edward; Brown, Michael S; Cheekatamarla, Praveen; Deng, Thomas; Dimitrakopoulos, James; Litka, Anthony F

    2013-11-19

    A reactor system is integrated internally within an anode-side cavity of a fuel cell. The reactor system is configured to convert hydrocarbons to smaller species while mitigating the lower production of solid carbon. The reactor system may incorporate one or more of a pre-reforming section, an anode exhaust gas recirculation device, and a reforming section.

  20. Business Intelligence Applied to the ALMA Software Integration Process

    Science.gov (United States)

    Zambrano, M.; Recabarren, C.; González, V.; Hoffstadt, A.; Soto, R.; Shen, T.-C.

    2012-09-01

    Software quality assurance and planning of an astronomy project is a complex task, specially if it is a distributed collaborative project such as ALMA, where the development centers are spread across the globe. When you execute a software project there is much valuable information about this process itself that you might be able to collect. One of the ways you can receive this input is via an issue tracking system that will gather the problem reports relative to software bugs captured during the testing of the software, during the integration of the different components or even worst, problems occurred during production time. Usually, there is little time spent on analyzing them but with some multidimensional processing you can extract valuable information from them and it might help you on the long term planning and resources allocation. We present an analysis of the information collected at ALMA from a collection of key unbiased indicators. We describe here the extraction, transformation and load process and how the data was processed. The main goal is to assess a software process and get insights from this information.

  1. A Web-Based Integration Procedure for the Development of Reconfigurable Robotic Work-Cells

    Directory of Open Access Journals (Sweden)

    Paulo Ferreira

    2013-07-01

    Full Text Available Concepts related to the development of reconfigurable manufacturing systems (RMS and methodologies to provide the best practices in the processing industry and factory automation, such as system integration and web-based technology, are major issues in designing next-generation manufacturing systems (NGMS. Adaptable and integrable devices are crucial for the success of NGMS. In robotic cells the integration of manufacturing components is essential to accelerate system adaptability. Sensors, control architectures and communication technologies have contributed to achieving further agility in reconfigurable factories. In this work a web-based robotic cell integration procedure is proposed to aid the identification of reconfigurable issues and requirements. This methodology is applied to an industrial robot manipulator to enhance system flexibility towards the development of a reconfigurable robotic platform.

  2. Integrative device and process of oxidization, degassing, acidity adjustment of 1BP from APOR process

    Energy Technology Data Exchange (ETDEWEB)

    Zuo, Chen; Zheng, Weifang, E-mail: wfazh@ciae.ac.cn; Yan, Taihong; He, Hui; Li, Gaoliang; Chang, Shangwen; Li, Chuanbo; Yuan, Zhongwei

    2016-02-15

    Graphical abstract: Previous (left) and present (right) device of oxidation, degassing, acidity adjustment of 1BP. - Highlights: • We designed an integrative device and process. • The utilization efficiency of N{sub 2}O{sub 4} is increased significantly. • Our work results in considerable simplification of the device. • Process parameters are determined by experiments. - Abstract: Device and process of oxidization, degassing, acidity adjustment of 1BP (The Pu production feed from U/Pu separation section) from APOR process (Advanced Purex Process based on Organic Reductants) were improved through rational design and experiments. The device was simplified and the process parameters, such as feed position and flow ratio, were determined by experiments. Based on this new device and process, the reductants N,N-dimethylhydroxylamine (DMHAN) and methylhydrazine (MMH) in 1BP solution could be oxidized with much less N{sub 2}O{sub 4} consumption.

  3. New ways of integrating material knowledge into the design process

    DEFF Research Database (Denmark)

    Højris, Anders; Nielsen, Louise Møller

    2013-01-01

    – based on technical performance, no longer apply. Accordingly the approach in this paper is to view information and knowledge about materials through the perspective of organizational memory and technology brokering. This paper is build upon two cases from the German based design studio: designaffairs...... libraries and thereby access to information on new material possibilities has also changed the way designers integrate knowledge about materials into the design process. This means that the traditional design process model, where the selection of materials takes place after the design of form and function...... in order to help clients to find the right material among hundreds of samples. Furthermore a number of material libraries have also been developed into online database, which provides detailed information about new material and makes the information accessible from almost everywhere. The access to material...

  4. Integrated project scheduling and staff assignment with controllable processing times.

    Science.gov (United States)

    Fernandez-Viagas, Victor; Framinan, Jose M

    2014-01-01

    This paper addresses a decision problem related to simultaneously scheduling the tasks in a project and assigning the staff to these tasks, taking into account that a task can be performed only by employees with certain skills, and that the length of each task depends on the number of employees assigned. This type of problems usually appears in service companies, where both tasks scheduling and staff assignment are closely related. An integer programming model for the problem is proposed, together with some extensions to cope with different situations. Additionally, the advantages of the controllable processing times approach are compared with the fixed processing times. Due to the complexity of the integrated model, a simple GRASP algorithm is implemented in order to obtain good, approximate solutions in short computation times.

  5. Integrated Project Scheduling and Staff Assignment with Controllable Processing Times

    Directory of Open Access Journals (Sweden)

    Victor Fernandez-Viagas

    2014-01-01

    Full Text Available This paper addresses a decision problem related to simultaneously scheduling the tasks in a project and assigning the staff to these tasks, taking into account that a task can be performed only by employees with certain skills, and that the length of each task depends on the number of employees assigned. This type of problems usually appears in service companies, where both tasks scheduling and staff assignment are closely related. An integer programming model for the problem is proposed, together with some extensions to cope with different situations. Additionally, the advantages of the controllable processing times approach are compared with the fixed processing times. Due to the complexity of the integrated model, a simple GRASP algorithm is implemented in order to obtain good, approximate solutions in short computation times.

  6. Nurse practitioner integration: Qualitative experiences of the change management process.

    Science.gov (United States)

    Lowe, Grainne; Plummer, Virginia; Boyd, Leanne

    2018-04-30

    The aim of this qualitative research was to explore perceptions of organisational change related to the integration of nurse practitioners from key nursing stakeholders. The ongoing delivery of effective and efficient patient services is reliant upon the development and sustainability of nurse practitioner roles. Examination of the factors contributing to the underutilization of nurse practitioner roles is crucial to inform future management policies. A change management theory is used to reveal the complexity involved. Qualitative interviews were undertaken using a purposive sampling strategy of key stakeholders. Thematic analysis was undertaken and key themes were correlated to the theoretical framework. The results confirm the benefits of nurse practitioner roles, but suggest organisational structures and embedded professional cultures present barriers to full role optimization. Complicated policy processes are creating barriers to the integration of nurse practitioner roles. The findings increase understanding of the links between strategic planning, human resource management, professional and organisational cultures, governance and politics in change management. Effective leadership drives the change process through the ability to align key components necessary for success. Sustainability of nurse practitioners relies on recognition of their full potential in the health care team. The results of this study highlight the importance of management and leadership in the promotion of advanced nursing skills and experience to better meet patient outcomes. The findings reinforce the potential of nurse practitioners to deliver patient centred, timely and efficient health care. © 2018 John Wiley & Sons Ltd.

  7. Flexible Electronics: Integration Processes for Organic and Inorganic Semiconductor-Based Thin-Film Transistors

    Directory of Open Access Journals (Sweden)

    Fábio F. Vidor

    2015-07-01

    Full Text Available Flexible and transparent electronics have been studied intensively during the last few decades. The technique establishes the possibility of fabricating innovative products, from flexible displays to radio-frequency identification tags. Typically, large-area polymeric substrates such as polypropylene (PP or polyethylene terephthalate (PET are used, which produces new requirements for the integration processes. A key element for flexible and transparent electronics is the thin-film transistor (TFT, as it is responsible for the driving current in memory cells, digital circuits or organic light-emitting devices (OLEDs. In this paper, we discuss some fundamental concepts of TFT technology. Additionally, we present a comparison between the use of the semiconducting organic small-molecule pentacene and inorganic nanoparticle semiconductors in order to integrate TFTs suitable for flexible electronics. Moreover, a technique for integration with a submicron resolution suitable for glass and foil substrates is presented.

  8. Biodiesel production from Jatropha curcas: Integrated process optimization

    International Nuclear Information System (INIS)

    Huerga, Ignacio R.; Zanuttini, María Soledad; Gross, Martín S.; Querini, Carlos A.

    2014-01-01

    Highlights: • The oil obtained from Jatropha curcas fruits has high variability in its properties. • A process for biodiesel production has been developed for small scale projects. • Oil neutralization with the glycerine phase has important advantages. • The glycerine phase and the meal are adequate to produce biogas. - Abstract: Energy obtained from renewable sources has increased its participation in the energy matrix worldwide, and it is expected to maintain this tendency. Both in large and small scales, there have been numerous developments and research with the aim of generating fuels and energy using different raw materials such as alternative crops, algae and lignocellulosic residues. In this work, Jatropha curcas plantation from the North West of Argentina was studied, with the objective of developing integrated processes for low and medium sizes farms. In these cases, glycerine purification and meal detoxification processes represent a very high cost, and usually are not included in the project. Consequently, alternative uses for these products are proposed. This study includes the evaluation of the Jatropha curcas crop during two years, evaluating the yields and oil properties. The solids left after the oil extraction were evaluated as solid fuels, the glycerine and the meal were used to generate biogas, and the oil was used to produce biodiesel. The oil pretreatment was carried out with the glycerine obtained in the biodiesel production process, thus neutralizing the free fatty acid, and decreasing the phosphorous and water content

  9. Pyrometallurgical processing of Integral Fast Reactor metal fuels

    International Nuclear Information System (INIS)

    Battles, J.E.; Miller, W.E.; Gay, E.C.

    1991-01-01

    The pyrometallurgical process for recycling spent metal fuels from the Integral Fast Reactor is now in an advanced state of development. This process involves electrorefining spent fuel with a cadmium anode, solid and liquid cathodes, and a molten salt electrolyte (LiCl-KCl) at 500 degrees C. The initial process feasibility and flowsheet verification studies have been conducted in a laboratory-scale electrorefiner. Based on these studies, a dual cathode approach has been adopted, where uranium is recovered on a solid cathode mandrel and uranium-plutonium is recovered in a liquid cadmium cathode. Consolidation and purification (salt and cadmium removal) of uranium and uranium-plutonium products from the electrorefiner have been successful. The process is being developed with the aid of an engineering-scale electrorefiner, which has been successfully operated for more than three years. In this electrorefiner, uranium has been electrotransported from the cadmium anode to a solid cathode in 10 kg quantities. Also, anodic dissolution of 10 kg batches of chopped, simulated fuel (U--10% Zr) has been demonstrated. Development of the liquid cadmium cathode for recovering uranium-plutonium is under way

  10. Wnt6 maintains anterior escort cells as an integral component of the germline stem cell niche.

    Science.gov (United States)

    Wang, Xiaoxi; Page-McCaw, Andrea

    2018-02-07

    Stem cells reside in a niche, a local environment whose cellular and molecular complexity is still being elucidated. In Drosophila ovaries, germline stem cells depend on cap cells for self-renewing signals and physical attachment. Germline stem cells also contact the anterior escort cells, and here we report that anterior escort cells are absolutely required for germline stem cell maintenance. When escort cells die from impaired Wnt signaling or hid expression, the loss of anterior escort cells causes loss of germline stem cells. Anterior escort cells function as an integral niche component by promoting DE-cadherin anchorage and by transiently expressing the Dpp ligand to promote full-strength BMP signaling in germline stem cells. Anterior escort cells are maintained by Wnt6 ligands produced by cap cells; without Wnt6 signaling, anterior escort cells die leaving vacancies in the niche, leading to loss of germline stem cells. Our data identify anterior escort cells as constituents of the germline stem cell niche, maintained by a cap cell-produced Wnt6 survival signal. © 2018. Published by The Company of Biologists Ltd.

  11. Workshop - Solar cells and daylight. Solar cell house. House building with integrated solar cell systems; Workshop - Solceller og dagslys. Solcellehus. Boligbyggeri med integrerede solcelleanlaeg

    Energy Technology Data Exchange (ETDEWEB)

    Schroeder, Mio; Hansen, Ellen Kathrine

    2005-04-15

    The workshop 'Solar cells and daylight' at Aarhus School of Architecture aimed at studying and developing architectural potentials of integrating solar cell systems in building components for future house building. The aim of the process was to stress that technical conditions such as energy technological component design might work as central points of support in the future shaping and organisation of qualitative and functional design of houses. (BA)

  12. High-definition mapping of retroviral integration sites defines the fate of allogeneic T cells after donor lymphocyte infusion.

    Directory of Open Access Journals (Sweden)

    Claudia Cattoglio

    2010-12-01

    Full Text Available The infusion of donor lymphocytes transduced with a retroviral vector expressing the HSV-TK suicide gene in patients undergoing hematopoietic stem cell transplantation for leukemia/lymphoma promotes immune reconstitution and prevents infections and graft-versus-host disease. Analysis of the clonal dynamics of genetically modified lymphocytes in vivo is of crucial importance to understand the potential genotoxic risk of this therapeutic approach. We used linear amplification-mediated PCR and pyrosequencing to build a genome-wide, high-definition map of retroviral integration sites in the genome of peripheral blood T cells from two different donors and used gene expression profiling and bioinformatics to associate integration clusters to transcriptional activity and to genetic and epigenetic features of the T cell genome. Comparison with matched random controls and with integrations obtained from CD34(+ hematopoietic stem/progenitor cells showed that integration clusters occur within chromatin regions bearing epigenetic marks associated with active promoters and regulatory elements in a cell-specific fashion. Analysis of integration sites in T cells obtained ex vivo two months after infusion showed no evidence of integration-related clonal expansion or dominance, but rather loss of cells harboring integration events interfering with RNA post-transcriptional processing. The study shows that high-definition maps of retroviral integration sites are a powerful tool to analyze the fate of genetically modified T cells in patients and the biological consequences of retroviral transduction.

  13. Modern integrated environmental monitoring and processing systems for nuclear facilities

    International Nuclear Information System (INIS)

    Oprea, I.

    2000-01-01

    The continuous activity to survey and monitor releases and the current radiation levels in the vicinity of a nuclear object is essential for person and environment protection. Considering the vast amount of information and data needed to keep an updated overview of a situation both during the daily surveillance work and during accident situations, the need for an efficient monitoring and processing system is evident. The rapid development, both in computer technology and in telecommunications, the evolution of fast and accurate computer codes enabling the on-line calculations improve the quality of decision-making in complex situations and assure a high efficiency. The monitoring and processing systems are used both for environmental protection and for controlling nuclear power plant emergency and post-accident situations. Such a system can offer information to the radiation management systems in order to assess the consequences of nuclear accidents and to establish a basis for right decisions in civil defense. The integrated environmental monitoring systems have as main task to record, collect, process and transmit the radiation levels and weather data, incorporating a number of stationary or mobile radiation monitoring equipment, weather parameter measuring station, an information processing center and the communication network, all running under a real-time operating system.They provide the automatic data collection on-line and off-line, remote diagnostic, advanced presentation techniques, including a graphically oriented executive support, which has the ability to respond to an emergency by geographical representation of the hazard zones on the map. The systems are based on local intelligent measuring and transmission units, simultaneous processing and data presentation using a real-time operating system for personal computers and geographical information system (GIS). All information can be managed directly from the map by multilevel data retrieving and

  14. Transient flow analysis of integrated valve opening process

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Xinming; Qin, Benke; Bo, Hanliang, E-mail: bohl@tsinghua.edu.cn; Xu, Xingxing

    2017-03-15

    Highlights: • The control rod hydraulic driving system (CRHDS) is a new type of built-in control rod drive technology and the integrated valve (IV) is the key control component. • The transient flow experiment induced by IV is conducted and the test results are analyzed to get its working mechanism. • The theoretical model of IV opening process is established and applied to get the changing rule of the transient flow characteristic parameters. - Abstract: The control rod hydraulic driving system (CRHDS) is a new type of built-in control rod drive technology and the IV is the key control component. The working principle of integrated valve (IV) is analyzed and the IV hydraulic experiment is conducted. There is transient flow phenomenon in the valve opening process. The theoretical model of IV opening process is established by the loop system control equations and boundary conditions. The valve opening boundary condition equation is established based on the IV three dimensional flow field analysis results and the dynamic analysis of the valve core movement. The model calculation results are in good agreement with the experimental results. On this basis, the model is used to analyze the transient flow under high temperature condition. The peak pressure head is consistent with the one under room temperature and the pressure fluctuation period is longer than the one under room temperature. Furthermore, the changing rule of pressure transients with the fluid and loop structure parameters is analyzed. The peak pressure increases with the flow rate and the peak pressure decreases with the increase of the valve opening time. The pressure fluctuation period increases with the loop pipe length and the fluctuation amplitude remains largely unchanged under different equilibrium pressure conditions. The research results lay the base for the vibration reduction analysis of the CRHDS.

  15. Processes subject to integrated pollution control. Petroleum processes: oil refining and associated processes

    International Nuclear Information System (INIS)

    1995-01-01

    This document, part of a series offering guidance on pollution control regulations issued by Her Majesty's Inspectorate of Pollution, (HMIP) focuses on petroleum processes such as oil refining and other associated processes. The various industrial processes used, their associated pollution release routes into the environment and techniques for controlling these releases are all discussed. Environmental quality standards are related to national and international agreements on pollution control and abatement. HMIP's work on air, water and land pollution monitoring is also reported. (UK)

  16. The integrated model of innovative processes management in foreign countries

    Directory of Open Access Journals (Sweden)

    M. T. Kurametova

    2017-01-01

    Full Text Available The formation of an innovative economy must correspond to the promising areas of development of scientific, technical and social progress. To ensure sustainable innovative development of the national economy, it is not only necessary to develop our own tools and mechanisms that are characteristic of the domestic management model, but also the rational use of foreign experience in this field. Analysis of international experience in the use of various tools and mechanisms, management structures for the creation of high-tech and knowledge-based enterprises showed: the integrated nature of innovative development and modernization of the economy is the most sound methodological approach of a phased, systemic transition to new technological structures; When developing tools and mechanisms for innovative development of the economy, one should take into account the actual state of the material and technical base and the existing industrial structure of production, take into account the real possibilities of using different types of resources. The greatest innovation activity is shown by those countries in which the national integrated system effectively provides favorable conditions for the development and introduction of innovations in various spheres of life. International experience in the use of forms of governance can be considered as a mobile system of relations with the real sector of the economy. In the article is given the experience of foreign countries, and examples of adaptation for Kazakhstan integrated models of management of innovative processes to create high-tech enterprises, innovative products which can be competitive in the world market. The author highlighted the role of JSC “Kazakhtelecom” with the widespread provision of public services, having the status of a National operator associated with the provision of the services including long-distance and an international telecommunication for telecommunication networks in General

  17. Critical factors in the implementation process of integrated management systems

    Directory of Open Access Journals (Sweden)

    Ademir Antonio Ferreira

    2015-09-01

    Full Text Available This study is the result of research whose purpose was to study the implementation process of integrated management systems, called ERP Enterprise Resource Planning in the business environment. This study, more specifically, tried to identify the variables in this process and that, somehow, made it easy or caused some type of difficulty implementing the system. Based on the mixed method approach (Creswell, 2003, the study was performed by means of the content analysis of technical and scientific publications about this theme and by means of a field research for data collection from primary sources. The content analysis was based on the per mile procedure by Bardin (1977, making it possible to identify critical factors that may be found in the implementation of ERP system projects. Primary data was collected from structured interviews with the managers in charge of the implementation of the system, in each of the 12 companies in different sectors of the economy and based in Brazil. Based on this information, it was possible to test the factors extracted from the content analysis and then develop a list of factors that may effectively influence the implementation process of the system. In order to recognize the possible relations between the selected factors, the Spearman (rsp correlation coefficient was applied and the multiple regression analysis was performed by means of the stepwise procedure. The purpose of the regression analysis was to determine the relation of the “Assessment of the Implementation” dependent variable with other dependent variables in the selected categories. The results of these analyses showed that the support of the top management, the communication process for the clear evidence of this support, the technical support of the ERP program provider together with the project team expertise, training and qualification processes of the team in the system operation are significantly correlated and relevant factors for a

  18. Process integration and pinch analysis in sugarcane industry

    Energy Technology Data Exchange (ETDEWEB)

    Prado, Adelk de Carvalho; Pinheiro, Ricardo Brant [UFMG, Departamento de Engenharia Nuclear, Programa de Pos-Graduacao em Ciencias e Tecnicas Nucleares, Belo Horizonte, MG (Brazil)], E-mail: rbp@nuclear.ufmg.br

    2010-07-01

    Process integration techniques were applied, particularly through the Pinch Analysis method, to sugarcane industry. Research was performed upon harvest data from an agroindustrial complex which processes sugarcane plant in excess of 3.5 million metric tons per year, producing motor fuel grade ethanol, standard quality sugar, and delivering excess electric power to the grid. Pinch Analysis was used in assessing internal heat recovery as well as external utility demand targets, while keeping the lowest but economically achievable targets for entropy increase. Efficiency on the use of energy was evaluated for the plant as it was found (the base case) as well as for five selected process and/or plant design modifications, always with guidance of the method. The first alternative design (case 2) was proposed to evaluate equipment mean idle time in the base case, to support subsequent comparisons. Cases 3 and 4 were used to estimate the upper limits of combined heat and power generation while raw material supply of the base case is kept; both the cases did not prove worth implementing. Cases 5 and 6 were devised to deal with the bottleneck of the plant, namely boiler capacity, in order to allow for some production increment. Inexpensive, minor modifications considered in case 5 were found unable to produce reasonable outcome gain. Nevertheless, proper changes in cane juice evaporation section (case 6) could allow sugar and ethanol combined production to rise up to 9.1% relative to the base case, without dropping cogenerated power. (author)

  19. The IBA Easy-E-Beam™ Integrated Processing System

    Science.gov (United States)

    Cleland, Marshall R.; Galloway, Richard A.; Lisanti, Thomas F.

    2011-06-01

    IBA Industrial Inc., (formerly known as Radiation Dynamics, Inc.) has been making high-energy and medium-energy, direct-current proton and electron accelerators for research and industrial applications for many years. Some industrial applications of high-power electron accelerators are the crosslinking of polymeric materials and products, such as the insulation on electrical wires, multi-conductor cable jackets, heat-shrinkable plastic tubing and film, plastic pipe, foam and pellets, the partial curing of rubber sheet for automobile tire components, and the sterilization of disposable medical devices. The curing (polymerization and crosslinking) of carbon and glass fiber-reinforced composite plastic parts, the preservation of foods and the treatment of waste materials are attractive possibilities for future applications. With electron energies above 1.0 MeV, the radiation protection for operating personnel is usually provided by surrounding the accelerator facility with thick concrete walls. With lower energies, steel and lead panels can be used, which are substantially thinner and more compact than the equivalent concrete walls. IBA has developed a series of electron processing systems called Easy-e-Beam™ for the medium energy range from 300 keV to 1000 keV. These systems include the shielding as an integral part of a complete radiation processing facility. The basic concepts of the electron accelerator, the product processing equipment, the programmable control system, the configuration of the radiation shielding and some performance characteristics are described in this paper.

  20. The IBA Easy-E-Beam Integrated Processing System

    International Nuclear Information System (INIS)

    Cleland, Marshall R.; Galloway, Richard A.; Lisanti, Thomas F.

    2011-01-01

    IBA Industrial Inc., (formerly known as Radiation Dynamics, Inc.) has been making high-energy and medium-energy, direct-current proton and electron accelerators for research and industrial applications for many years. Some industrial applications of high-power electron accelerators are the crosslinking of polymeric materials and products, such as the insulation on electrical wires, multi-conductor cable jackets, heat-shrinkable plastic tubing and film, plastic pipe, foam and pellets, the partial curing of rubber sheet for automobile tire components, and the sterilization of disposable medical devices. The curing (polymerization and crosslinking) of carbon and glass fiber-reinforced composite plastic parts, the preservation of foods and the treatment of waste materials are attractive possibilities for future applications. With electron energies above 1.0 MeV, the radiation protection for operating personnel is usually provided by surrounding the accelerator facility with thick concrete walls. With lower energies, steel and lead panels can be used, which are substantially thinner and more compact than the equivalent concrete walls. IBA has developed a series of electron processing systems called Easy-e-Beam for the medium energy range from 300 keV to 1000 keV. These systems include the shielding as an integral part of a complete radiation processing facility. The basic concepts of the electron accelerator, the product processing equipment, the programmable control system, the configuration of the radiation shielding and some performance characteristics are described in this paper.

  1. The importance of sensory integration processes for action cascading

    Science.gov (United States)

    Gohil, Krutika; Stock, Ann-Kathrin; Beste, Christian

    2015-01-01

    Dual tasking or action cascading is essential in everyday life and often investigated using tasks presenting stimuli in different sensory modalities. Findings obtained with multimodal tasks are often broadly generalized, but until today, it has remained unclear whether multimodal integration affects performance in action cascading or the underlying neurophysiology. To bridge this gap, we asked healthy young adults to complete a stop-change paradigm which presented different stimuli in either one or two modalities while recording behavioral and neurophysiological data. Bimodal stimulus presentation prolonged response times and affected bottom-up and top-down guided attentional processes as reflected by the P1 and N1, respectively. However, the most important effect was the modulation of response selection processes reflected by the P3 suggesting that a potentially different way of forming task goals operates during action cascading in bimodal vs. unimodal tasks. When two modalities are involved, separate task goals need to be formed while a conjoint task goal may be generated when all stimuli are presented in the same modality. On a systems level, these processes seem to be related to the modulation of activity in fronto-polar regions (BA10) as well as Broca's area (BA44). PMID:25820681

  2. Integration Processes on Civil Service Reform in the Eurasian Space

    Directory of Open Access Journals (Sweden)

    George A. Borshevskiy

    2016-01-01

    Full Text Available In the article was studied the process of reforming the institute of civil service in the countries of the Eurasian space (e.g. Russia, Belarus and Kazakhstan. The integration of national systems of public administration and, in particular, the civil service, is an important factor contributing to the implementation of the centripetal tendencies in the post-Soviet space. The research methodology is based on a combination of comparative legal analysis, historical retrospective method, normalization and scaling, structural-functional and system analysis. A comparison of the legal models of public service was made in research. The author puts forward the hypothesis that it is presence the relationship between the quantitative changes (for example, number of employees of civil service and the dynamics of macroeconomic indicators (e.g. number of employed in the economy. In this regard were observed common trends. On materials of the statistical surveys were considered quantitative changes in national systems of civil service. The study of the socio-demographic characteristics of the public service (gender, age, profession allowed to formulate conclusions about the general and specific trends in the reform of the civil service of the analyzed countries. A number of values were first calculated by the author. The work is intended to become the basis for a broad international research on the development of civil service, which is the central mechanism for implementation the integration in the post-Soviet space.

  3. Integrated preventive maintenance and production decisions for imperfect processes

    International Nuclear Information System (INIS)

    Nourelfath, Mustapha; Nahas, Nabil; Ben-Daya, Mohamed

    2016-01-01

    This paper integrates production, maintenance, and quality for an imperfect process in a multi-period multi-product capacitated lot-sizing context. The production system is modeled as an imperfect machine, whose the status is considered to be either in-control or out-of-control. When the machine is out of control, it produces a fraction of nonconforming items. During each period, this machine is inspected and imperfect preventive maintenance activities are simultaneously performed to reduce its age, proportional to the preventive maintenance level. The objective is to minimize the total cost, while satisfying the demand for all products. Our optimization model allows for a joint selection of the optimal values of production plan, and the maintenance policy, while taking into account quality related costs. A solution algorithm is developed and illustrative numerical examples are presented. It is found that the increase in PM level leads to reductions in quality control costs. Furthermore, if the cost of performing PM is high to the point where it is not compensated for by reductions in the quality related costs, then performing PM is not justifiable. Finally, using non-periodic preventive maintenance with the possibility of different preventive maintenance levels may result in an improvement of the total cost. - Highlights: • We integrate production, maintenance, and quality. • We evaluate all the expected costs. • Our model allows for a joint selection of the optimal values. • A solution algorithm is developed. • Increasing PM level will decrease quality control costs.

  4. UNCERTAINTY IN THE PROCESS INTEGRATION FOR THE BIOREFINERIES DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Meilyn González Cortés

    2015-07-01

    Full Text Available This paper presents how the design approaches with high level of flexibility can reduce the additional costs of the strategies that apply overdesign factors to consider parameters with uncertainty that impact on the economic feasibility of a project. The elements with associate uncertainties and that are important in the configurations of the process integration under a biorefinery scheme are: raw material, raw material technologies of conversion, and variety of products that can be obtained. From the analysis it is obtained that in the raw materials and products with potentialities in a biorefinery scheme, there are external uncertainties such as availability, demands and prices in the market. Those external uncertainties can determine their impact on the biorefinery and also in the product prices we can find minimum and maximum limits that can be identified in intervals which should be considered for the project economic evaluation and the sensibility analysis due to varied conditions.

  5. Clinical process in an integrative psychotherapy for self-wounds.

    Science.gov (United States)

    Wolfe, Barry E

    2013-09-01

    In this article, I will briefly describe the clinical process of an integrative psychotherapy for the healing of self-wounds, including its intended interventions and the variability of their application and outcome. Four specific strategies will be considered, including (a) the role of empathy throughout the course of therapy; (b) exposure therapy as a paradigmatic treatment for the treatment of feared thoughts, behavior, and emotions; (c) focusing and other experiential interventions for eliciting self-wounds; and (d) modification and healing of self-wounds with an individualized array of psychodynamic, experiential, and cognitive-behavioral strategies. In addition, we will briefly consider the impact of transference and countertransference on the trajectory of therapy. 2013 APA, all rights reserved

  6. An Integrated Numerical Model of the Spray Forming Process

    DEFF Research Database (Denmark)

    Pryds, Nini; Hattel, Jesper; Pedersen, Trine Bjerre

    2002-01-01

    of the deposition model is accomplished using a 2D cylindrical heat flow model. This model is now coupled with an atomization model via a log-normal droplet size distribution. The coupling between the atomization and the deposition is accomplished by ensuring that the total droplet size distribution of the spray......In this paper, an integrated approach for modelling the entire spray forming process is presented. The basis for the analysis is a recently developed model which extents previous studies and includes the interaction between an array of droplets and the enveloping gas. The formulation...... is in fact the summation of 'local' droplet size distributions along the r-axis. A key parameter, which determines the yield and the shape of the deposit material, is the sticking efficiency. The sticking phenomenon is therefore incorporated into the deposition model. (C) 2002 Acta Materialia Inc. Published...

  7. PERSPECTIVES ON INTEROPERABILITY INTEGRATION WITHIN NATO DEFENSE PLANNING PROCESS

    Directory of Open Access Journals (Sweden)

    Florian CIOCAN

    2011-01-01

    Full Text Available Interoperability is not a new area of effort at NATO level. In fact, interoperability and more specifi cally standardization, has been a key element of the Alliance’s approach to fi elding forces for decades. But as the security and operational environment has been in a continuous change, the need to face the new threats and the current involvement in challenging operations in Afghanistan and elsewhere alongside with the necessity to interoperate at lower and lower levels of command with an increasing number of nations, including non-NATO ISAF partners, NGOs, and other organizations, have made the task even more challenging. In this respect Interoperability Integration within NATO Defense Planning Process will facilitate the timely identifi cation, development and delivery of required forces and capabilities that are interoperable and adequately prepared, equipped, trained and supported to undertake the Alliance’s full spectrum of missions.

  8. Quantifying chaotic dynamics from integrate-and-fire processes

    Energy Technology Data Exchange (ETDEWEB)

    Pavlov, A. N. [Department of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov (Russian Federation); Saratov State Technical University, Politehnicheskaya Str. 77, 410054 Saratov (Russian Federation); Pavlova, O. N. [Department of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov (Russian Federation); Mohammad, Y. K. [Department of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov (Russian Federation); Tikrit University Salahudin, Tikrit Qadisiyah, University Str. P.O. Box 42, Tikrit (Iraq); Kurths, J. [Potsdam Institute for Climate Impact Research, Telegraphenberg A 31, 14473 Potsdam (Germany); Institute of Physics, Humboldt University Berlin, 12489 Berlin (Germany)

    2015-01-15

    Characterizing chaotic dynamics from integrate-and-fire (IF) interspike intervals (ISIs) is relatively easy performed at high firing rates. When the firing rate is low, a correct estimation of Lyapunov exponents (LEs) describing dynamical features of complex oscillations reflected in the IF ISI sequences becomes more complicated. In this work we discuss peculiarities and limitations of quantifying chaotic dynamics from IF point processes. We consider main factors leading to underestimated LEs and demonstrate a way of improving numerical determining of LEs from IF ISI sequences. We show that estimations of the two largest LEs can be performed using around 400 mean periods of chaotic oscillations in the regime of phase-coherent chaos. Application to real data is discussed.

  9. Second stage gasifier in staged gasification and integrated process

    Science.gov (United States)

    Liu, Guohai; Vimalchand, Pannalal; Peng, Wan Wang

    2015-10-06

    A second stage gasification unit in a staged gasification integrated process flow scheme and operating methods are disclosed to gasify a wide range of low reactivity fuels. The inclusion of second stage gasification unit operating at high temperatures closer to ash fusion temperatures in the bed provides sufficient flexibility in unit configurations, operating conditions and methods to achieve an overall carbon conversion of over 95% for low reactivity materials such as bituminous and anthracite coals, petroleum residues and coke. The second stage gasification unit includes a stationary fluidized bed gasifier operating with a sufficiently turbulent bed of predefined inert bed material with lean char carbon content. The second stage gasifier fluidized bed is operated at relatively high temperatures up to 1400.degree. C. Steam and oxidant mixture can be injected to further increase the freeboard region operating temperature in the range of approximately from 50 to 100.degree. C. above the bed temperature.

  10. Integrating fuel cell power systems into building physical plants

    Energy Technology Data Exchange (ETDEWEB)

    Carson, J. [KCI Technologies, Inc., Hunt Valley, MD (United States)

    1996-12-31

    This paper discusses the integration of fuel cell power plants and absorption chillers to cogenerate chilled water or hot water/steam for all weather air conditioning as one possible approach to building system applications. Absorption chillers utilize thermal energy in an absorption based cycle to chill water. It is feasible to use waste heat from fuel cells to provide hydronic heating and cooling. Performance regimes will vary as a function of the supply and quality of waste heat. Respective performance characteristics of fuel cells, absorption chillers and air conditioning systems will define relationships between thermal and electrical load capacities for the combined systems. Specifically, this paper develops thermodynamic relationships between bulk electrical power and cooling/heating capacities for combined fuel cell and absorption chiller system in building applications.

  11. Economic competitiveness of fuel cell onsite integrated energy systems

    Science.gov (United States)

    Bollenbacher, G.

    1983-01-01

    The economic competitiveness of fuel cell onsite integrated energy systems (OS/IES) in residential and commercial buildings is examined. The analysis is carried out for three different buildings with each building assumed to be at three geographic locations spanning a range of climatic conditions. Numerous design options and operating strategies are evaluated and two economic criteria are used to measure economic performance. In general the results show that fuel cell OS/IES's are competitive in most regions of the country if the OS/IES is properly designed. The preferred design is grid connected, makes effective use of the fuel cell's thermal output, and has a fuel cell powerplant sized for the building's base electrical load.

  12. Integration of nanoparticle cell lysis and microchip PCR for one-step rapid detection of bacteria.

    Science.gov (United States)

    Wan, Weijie; Yeow, John T W

    2012-04-01

    This paper describes an integrated microchip system as an efficient and cost-effective solution involving Nanotechnology and Lab-on-a-Chip technology for the rapid detection of bacteria. The system is based on using surface-modified gold nanoparticles for efficient cell lysis followed by microchip PCR without having to remove the nanoparticles from the PCR solution. Poly(quaternary ammonium) modified gold nanoparticles are used to provide a novel and efficient cell lysis method without the need to go through time-consuming, expensive and complicated microfabrication processes as most of current cell lysis methods for Lab-on-a-Chip applications do. It also facilitates the integration of cell lysis and PCR by sharing the same reaction chamber as PCR uses. It is integrated with a prototype microchip PCR system consisting of a physical microchip PCR device and an automated temperature control mechanism. The research work explores solutions for the problem of PCR inhibition caused by gold nanoparticles as well as for the problem of non-specific PCR amplification in the integrated microchip system. It also explores the possibility of greatly reducing PCR cycling time to achieve the same result compared to the protocol for a regular PCR machine. The simplicity of the setup makes it easy to be integrated with other Lab-on-a-Chip functional modules to create customized solutions for target applications.

  13. Integrated HLW Conceptual Process Flowsheet(s) for the Crystalline Silicotitanate Process SRDF-98-04

    International Nuclear Information System (INIS)

    Jacobs, R.A.

    1998-01-01

    The Strategic Research and Development Fund (SRDF) provided funds to develop integrated conceptual flowsheets and material balances for a CST process as a potential replacement for, or second generation to, the ITP process. This task directly supports another SRDF task: Glass Form for HLW Sludge with CST, SRDF-98-01, by M. K. Andrews which seeks to further develop sludge/CST glasses that could be used if the ITP process were replaced by CST ion exchange. The objective of the proposal was to provide flowsheet support for development and evaluation of a High Level Waste Division process to replace ITP. The flowsheets would provide a conceptual integrated material balance showing the impact on the HLW division. The evaluation would incorporate information to be developed by Andrews and Harbour on CST/DWPF glass formulations and provide the bases for evaluating the economic impact of the proposed replacement process. Coincident with this study, the Salt Disposition Team began its evaluation of alternatives for disposition of the HLW salts in the SRS waste tanks. During that time, the CST IX process was selected as one of four alternatives (of eighteen Phase II alternatives) for further evaluation during Phase III

  14. Prespacer processing and specific integration in a Type I-A CRISPR system

    Science.gov (United States)

    Rollie, Clare; Graham, Shirley; Rouillon, Christophe

    2018-01-01

    Abstract The CRISPR–Cas system for prokaryotic adaptive immunity provides RNA-mediated protection from viruses and mobile genetic elements. Adaptation is dependent on the Cas1 and Cas2 proteins along with varying accessory proteins. Here we analyse the process in Sulfolobus solfataricus, showing that while Cas1 and Cas2 catalyze spacer integration in vitro, host factors are required for specificity. Specific integration also requires at least 400 bp of the leader sequence, and is dependent on the presence of hydrolysable ATP, suggestive of an active process that may involve DNA remodelling. Specific spacer integration is associated with processing of prespacer 3′ ends in a PAM-dependent manner. This is reflected in PAM-dependent processing of prespacer 3′ ends in vitro in the presence of cell lysate or the Cas4 nuclease, in a reaction consistent with PAM-directed binding and protection of prespacer DNA. These results highlight the diverse interplay between CRISPR–Cas elements and host proteins across CRISPR types. PMID:29228332

  15. Application of the Hydroecological Integrity Assessment Process for Missouri Streams

    Science.gov (United States)

    Kennen, Jonathan G.; Henriksen, James A.; Heasley, John; Cade, Brian S.; Terrell, James W.

    2009-01-01

    Natural flow regime concepts and theories have established the justification for maintaining or restoring the range of natural hydrologic variability so that physiochemical processes, native biodiversity, and the evolutionary potential of aquatic and riparian assemblages can be sustained. A synthesis of recent research advances in hydroecology, coupled with stream classification using hydroecologically relevant indices, has produced the Hydroecological Integrity Assessment Process (HIP). HIP consists of (1) a regional classification of streams into hydrologic stream types based on flow data from long-term gaging-station records for relatively unmodified streams, (2) an identification of stream-type specific indices that address 11 subcomponents of the flow regime, (3) an ability to establish environmental flow standards, (4) an evaluation of hydrologic alteration, and (5) a capacity to conduct alternative analyses. The process starts with the identification of a hydrologic baseline (reference condition) for selected locations, uses flow data from a stream-gage network, and proceeds to classify streams into hydrologic stream types. Concurrently, the analysis identifies a set of non-redundant and ecologically relevant hydrologic indices for 11 subcomponents of flow for each stream type. Furthermore, regional hydrologic models for synthesizing flow conditions across a region and the development of flow-ecology response relations for each stream type can be added to further enhance the process. The application of HIP to Missouri streams identified five stream types ((1) intermittent, (2) perennial runoff-flashy, (3) perennial runoff-moderate baseflow, (4) perennial groundwater-stable, and (5) perennial groundwater-super stable). Two Missouri-specific computer software programs were developed: (1) a Missouri Hydrologic Assessment Tool (MOHAT) which is used to establish a hydrologic baseline, provide options for setting environmental flow standards, and compare past and

  16. Integrated coastal monitoring of a gas processing plant using native and caged mussels

    Energy Technology Data Exchange (ETDEWEB)

    Brooks, Steven, E-mail: sbr@niva.no [Norwegian Institute for Water Research (NIVA), Gaustadalleen 21, NO-0349 Oslo (Norway); Harman, Christopher [Norwegian Institute for Water Research (NIVA), Gaustadalleen 21, NO-0349 Oslo (Norway); Soto, Manu; Cancio, Ibon [CBET Res Grp, R and D Centre for Experimental Marine Biology and Biotechnology (PIE), Univ Basque Country, Areatza Z/G, Plentzia-Bizkaia, E-48620 Basque Country (Spain); Glette, Tormod [Det Norske Veritas (DNV), Veritasveien 1, 1363 Hovik (Norway); Marigomez, Ionan [CBET Res Grp, R and D Centre for Experimental Marine Biology and Biotechnology (PIE), Univ Basque Country, Areatza Z/G, Plentzia-Bizkaia, E-48620 Basque Country (Spain)

    2012-06-01

    The biological effects of a coastal process water (PW) discharge on native and caged mussels (Mytilus edulis) were assessed. Chemical analyses of mussel tissues and semi permeable membrane devices, along with a suite of biomarkers of different levels of biological complexity were measured. These were lysosomal membrane stability in haemocytes and digestive cells; micronuclei formation in haemocytes; changes in cell-type composition in the digestive gland epithelium; integrity of digestive gland tissue; peroxisome proliferation; and oxidative stress. Additionally the Integrative Biological Response (IBR/n) index was calculated. This integrative biomarker approach distinguished mussels, both native and caged, exhibiting different stress conditions not identified from the contaminant exposure. Mussels exhibiting higher stress responses were found with increased proximity to the PW discharge outlet. However, the biological effects reported could not be entirely attributed to the PW discharge based on the chemicals measured, but were likely due to either other chemicals in the discharge that were not measured, the general impact of the processing plant and or other activities in the local vicinity. - Highlights: Black-Right-Pointing-Pointer Good agreement between biomarkers for the different mussel groups. Black-Right-Pointing-Pointer IBR/n was able to differentiate between exposed and reference mussels. Black-Right-Pointing-Pointer Mussels closest to the PW outlet were in poorest health. Black-Right-Pointing-Pointer Chemical concentrations were low or undetected in all SPMD and mussel samples. Black-Right-Pointing-Pointer Biomarker responses could not be entirely attributed to the PW discharge.

  17. High temperature induced disruption of the cell wall integrity and structure in Pleurotus ostreatus mycelia.

    Science.gov (United States)

    Qiu, Zhiheng; Wu, Xiangli; Gao, Wei; Zhang, Jinxia; Huang, Chenyang

    2018-05-30

    Fungal cells are surrounded by a tight cell wall to protect them from harmful environmental conditions and to resist lysis. The synthesis and assembly determine the shape, structure, and integrity of the cell wall during the process of mycelial growth and development. High temperature is an important abiotic stress, which affects the synthesis and assembly of cell walls. In the present study, the chitin and β-1,3-glucan concentrations in the cell wall of Pleurotus ostreatus mycelia were changed after high-temperature treatment. Significantly higher chitin and β-1,3-glucan concentrations were detected at 36 °C than those incubated at 28 °C. With the increased temperature, many aberrant chitin deposition patches occurred, and the distribution of chitin in the cell wall was uneven. Moreover, high temperature disrupts the cell wall integrity, and P. ostreatus mycelia became hypersensitive to cell wall-perturbing agents at 36 °C. The cell wall structure tended to shrink or distorted after high temperature. The cell walls were observed to be thicker and looser by using transmission electron microscopy. High temperature can decrease the mannose content in the cell wall and increase the relative cell wall porosity. According to infrared absorption spectrum, high temperature broke or decreased the glycosidic linkages. Finally, P. ostreatus mycelial cell wall was easily degraded by lysing enzymes after high-temperature treatment. In other words, the cell wall destruction caused by high temperature may be a breakthrough for P. ostreatus to be easily infected by Trichoderma.

  18. Integrative Modeling of Electrical Properties of Pacemaker Cardiac Cells

    Science.gov (United States)

    Grigoriev, M.; Babich, L.

    2016-06-01

    This work represents modeling of electrical properties of pacemaker (sinus) cardiac cells. Special attention is paid to electrical potential arising from transmembrane current of Na+, K+ and Ca2+ ions. This potential is calculated using the NaCaX model. In this respect, molar concentration of ions in the intercellular space which is calculated on the basis of the GENTEX model is essential. Combined use of two different models allows referring this approach to integrative modeling.

  19. Label-free single-cell separation and imaging of cancer cells using an integrated microfluidic system

    DEFF Research Database (Denmark)

    Antfolk, Maria; Kim, Soo Hyeon; Koizumi, Saori

    2017-01-01

    , an integrated system is presented that efficiently eliminates this risk by integrating label-free separation with single cell arraying of the target cell population, enabling direct on-chip tumor cell identification and enumeration. Prostate cancer cells (DU145) spiked into a sample with whole blood...... a fully integrated system for rapid label-free separation and on-chip phenotypic characterization of circulating tumor cells from peripheral venous blood in clinical practice....

  20. Integrated Process Design and Control of Multi-element Reactive Distillation Processes

    DEFF Research Database (Denmark)

    Mansouri, Seyed Soheil; Sales-Cruz, Mauricio; Huusom, Jakob Kjøbsted

    2016-01-01

    In this work, integrated process design and control of reactive distillation processes involving multi-elements is presented. The reactive distillation column is designed using methods and tools which are similar in concept to non-reactive distillation design methods, such as driving force approach....... The methods employed in this work are based on equivalent element concept. This concept facilitates the representation of a multi-element reactive system as equivalent binary light and heavy key elements. First, the reactive distillation column is designed at the maximum driving force where through steady...

  1. Process for integrating surface drainage constraints on mine planning

    Energy Technology Data Exchange (ETDEWEB)

    Sawatsky, L.F; Ade, F.L.; McDonald, D.M.; Pullman, B.J. [Golder Associates Ltd., Calgary, AB (Canada)

    2009-07-01

    Surface drainage for mine closures must be considered during all phases of mine planning and design in order to minimize environmental impacts and reduce costs. This paper discussed methods of integrating mine drainage criteria and associated mine planning constraints into the mine planning process. Drainage constraints included stream diversions; fish compensation channels; collection receptacles for the re-use of process water; separation of closed circuit water from fresh water; and the provision of storage ponds. The geomorphic approach replicated the ability of natural channels to respond to local and regional changes in hydrology as well as channel disturbances from extreme flood events, sedimentation, debris, ice jams, and beaver activity. The approach was designed to enable a sustainable system and provide conveyance capacity for extreme floods without spillage to adjacent watersheds. Channel dimensions, bank and bed materials, sediment loads, bed material supplies and the hydrologic conditions of the analogue stream were considered. Hydrologic analyses were conducted to determine design flood flow. Channel routes, valley slopes, sinuosity, width, and depth were established. It was concluded that by incorporating the geomorphic technique, mine operators and designers can construct self-sustaining drainage systems that require little or no maintenance in the long-term. 7 refs.

  2. Integrating Process Mining and Cognitive Analysis to Study EHR Workflow.

    Science.gov (United States)

    Furniss, Stephanie K; Burton, Matthew M; Grando, Adela; Larson, David W; Kaufman, David R

    2016-01-01

    There are numerous methods to study workflow. However, few produce the kinds of in-depth analyses needed to understand EHR-mediated workflow. Here we investigated variations in clinicians' EHR workflow by integrating quantitative analysis of patterns of users' EHR-interactions with in-depth qualitative analysis of user performance. We characterized 6 clinicians' patterns of information-gathering using a sequential process-mining approach. The analysis revealed 519 different screen transition patterns performed across 1569 patient cases. No one pattern was followed for more than 10% of patient cases, the 15 most frequent patterns accounted for over half ofpatient cases (53%), and 27% of cases exhibited unique patterns. By triangulating quantitative and qualitative analyses, we found that participants' EHR-interactive behavior was associated with their routine processes, patient case complexity, and EHR default settings. The proposed approach has significant potential to inform resource allocation for observation and training. In-depth observations helped us to explain variation across users.

  3. Integrative techniques related to positive processes in psychotherapy.

    Science.gov (United States)

    Cromer, Thomas D

    2013-09-01

    This review compiles and evaluates a number of therapist interventions that have been found to significantly contribute to positive psychotherapy processes (i.e., increased alliance, patient engagement/satisfaction, and symptomatic improvement). Four forms of intervention are presented: Affect-focused, Supportive, Exploratory, and Patient-Therapist Interaction. The intention of this review is to link specific interventions to applied practice so that integrative clinicians can potentially use these techniques to improve their clinical work. To this end, there is the inclusion of theory and empirical studies from a range of orientations including Emotionally Focused, Psychodynamic, Client-Centered, Cognitive-Behavioral, Interpersonal, Eclectic, and Motivational Interviewing. Each of the four sections will include the theoretical basis and proposed mechanism of change for the intervention, research that supports its positive impact on psychotherapy processes, and conclude with examples demonstrating its use in actual practice. Clinical implications and considerations regarding the use of these interventions will also be presented. 2013 APA, all rights reserved

  4. Social networks in nursing work processes: an integrative literature review

    Directory of Open Access Journals (Sweden)

    Ana Cláudia Mesquita

    Full Text Available Abstract OBJECTIVE To identify and analyze the available evidence in the literature on the use of social networks in nursing work processes. METHOD An integrative review of the literature conducted in PubMed, CINAHL, EMBASE and LILACS databases in January 2016, using the descriptors social media, social networking, nursing, enfermagem, redes sociais, mídias sociais, and the keyword nursing practice, without year restriction. RESULTS The sample consisted of 27 international articles which were published between 2011 and 2016. The social networks used were Facebook (66.5%, Twitter (30% and WhatsApp (3.5%. In 70.5% of the studies, social networks were used for research purposes, in 18.5% they were used as a tool aimed to assist students in academic activities, and in 11% for executing interventions via the internet. CONCLUSION Nurses have used social networks in their work processes such as Facebook, Twitter and WhatsApp to research, teach and watch. The articles show several benefits in using such tools in the nursing profession; however, ethical considerations regarding the use of social networks deserve further discussion.

  5. Development of post-decontamination process after integrated EPN treatment

    International Nuclear Information System (INIS)

    Park, J. H.; Chung, U. S.; Lee, K. W.; Hwang, D. S.; Kim, T. J.; Hong, S. B.; Hwang, S. T.

    2010-02-01

    It is desirable to recycle or reuse the waste generated from nuclear facilities for the better economy of the nuclear industry. Metal shares a large portion of the waste and its reuse becomes a world wide interest. It is well known that the measurement of such a low radioactivity that is lower than the release criteria is not easy. It becomes more difficult when the contamination is not homogenous and the shape of metal waste is complex. In order to get the more accurate results of the measurement of low radioactivity, a melting process was proposed for homogenizing the residual contaminants and for not missing of hot spots of contamination. A induction furnace system was selected after evaluation of the processes and a furnace of 15 kg/batch scale with cooling water supply, inverter for high frequency electricity source and off gas treatment system was installed and operated. The homogeneity of the ingot was verified by using an experiment of the metal tracers and chemical tracers. The volume radioactivity limit of each nuclide was calculated. From these calculation results and comparison study with the limits valued defined in other countries and recommended by the IAEA, the criteria of volume radioactivity for the release of metal waste were proposed. In order to determine the target radioactivity in the integrated EPN decontamination, a correlation between the residual radioactivity and the public radiation dose was proposed

  6. Case Study: Accelerating Process Improvement by Integrating the TSP and CMMI

    National Research Council Canada - National Science Library

    Wall, Daniel S; McHale, James; Pomeroy-Huff, Marsha

    2005-01-01

    .... This case study describes the process improvement efforts of both NAVAIR divisions and how they integrated the two SEI technologies to accelerate process improvement within their organizations...

  7. Optically induced dielectropheresis sorting with automated medium exchange in an integrated optofluidic device resulting in higher cell viability.

    Science.gov (United States)

    Lee, Gwo-Bin; Wu, Huan-Chun; Yang, Po-Fu; Mai, John D

    2014-08-07

    We demonstrated the integration of a microfluidic device with an optically induced dielectrophoresis (ODEP) device such that the critical medium replacement process was performed automatically and the cells could be subsequently manipulated by using digitally projected optical images. ODEP has been demonstrated to generate sufficient forces for manipulating particles/cells by projecting a light pattern onto photoconductive materials which creates virtual electrodes. The production of the ODEP force usually requires a medium that has a suitable electrical conductivity and an appropriate dielectric constant. Therefore, a 0.2 M sucrose solution is commonly used. However, this requires a complicated medium replacement process before one is able to manipulate cells. Furthermore, the 0.2 M sucrose solution is not suitable for the long-term viability of cells. In comparison to conventional manual processes, our automated medium replacement process only took 25 minutes. Experimental data showed that there was up to a 96.2% recovery rate for the manipulated cells. More importantly, the survival rate of the cells was greatly enhanced due to this faster automated process. This newly developed microfluidic chip provided a promising platform for the rapid replacement of the cell medium and this was also the first time that an ODEP device was integrated with other active flow control components in a microfluidic device. By improving cell viability after cell manipulation, this design may contribute to the practical integration of ODEP modules into other lab-on-a-chip devices and biomedical applications in the future.

  8. Finite Element Analysis of Single Cell Stiffness Measurements Using PZT-Integrated Buckling Nanoneedles.

    Science.gov (United States)

    Rad, Maryam Alsadat; Tijjani, Auwal Shehu; Ahmad, Mohd Ridzuan; Auwal, Shehu Muhammad

    2016-12-23

    This paper proposes a new technique for real-time single cell stiffness measurement using lead zirconate titanate (PZT)-integrated buckling nanoneedles. The PZT and the buckling part of the nanoneedle have been modelled and validated using the ABAQUS software. The two parts are integrated together to function as a single unit. After calibration, the stiffness, Young's modulus, Poisson's ratio and sensitivity of the PZT-integrated buckling nanoneedle have been determined to be 0.7100 N·m -1 , 123.4700 GPa, 0.3000 and 0.0693 V·m·N -1 , respectively. Three Saccharomyces cerevisiae cells have been modelled and validated based on compression tests. The average global stiffness and Young's modulus of the cells are determined to be 10.8867 ± 0.0094 N·m -1 and 110.7033 ± 0.0081 MPa, respectively. The nanoneedle and the cell have been assembled to measure the local stiffness of the single Saccharomyces cerevisiae cells The local stiffness, Young's modulus and PZT output voltage of the three different size Saccharomyces cerevisiae have been determined at different environmental conditions. We investigated that, at low temperature the stiffness value is low to adapt to the change in the environmental condition. As a result, Saccharomyces cerevisiae becomes vulnerable to viral and bacterial attacks. Therefore, the proposed technique will serve as a quick and accurate process to diagnose diseases at early stage in a cell for effective treatment.

  9. CONSIDERATIONS FOR THE MASS AND ENERGY INTEGRATION IN THE SUGAR PROCESS PRODUCTION AND DERIVATIVE PROCESS

    Directory of Open Access Journals (Sweden)

    Dennis Abel Clavelo Sierra

    2015-04-01

    Full Text Available The current society needs now more than ever of industries that create new forms and methods where the saving of energy and materials is a fundamental aspect. For this reason, in the present investigation we present an outline with the considerations for the integration of the processes of sugar and other derived products, in an outline of bio refinery with the objective of achieving efficient processes with an appropriate use of the material resources and an efficient use of the energy, with minimum operation costs and investment. In the outline we take as base for the study, it is considered that the integrated complex has as basic input the sugarcane; it is also considered the variation of the prices of the products in the market. In the article we make an outline with the precise steps for the development of a methodology that allows analyzing the processes involved in the biorefinery outline and in this way to identify the common material and energy resources that the processes exchange. A heuristic diagram is presented that guides the strategy to continue for it.

  10. High titer oncolytic measles virus production process by integration of dielectric spectroscopy as online monitoring system.

    Science.gov (United States)

    Grein, Tanja A; Loewe, Daniel; Dieken, Hauke; Salzig, Denise; Weidner, Tobias; Czermak, Peter

    2018-05-01

    Oncolytic viruses offer new hope to millions of patients with incurable cancer. One promising class of oncolytic viruses is Measles virus, but its broad administration to cancer patients is currently hampered by the inability to produce the large amounts of virus needed for treatment (10 10 -10 12 virus particles per dose). Measles virus is unstable, leading to very low virus titers during production. The time of infection and time of harvest are therefore critical parameters in a Measles virus production process, and their optimization requires an accurate online monitoring system. We integrated a probe based on dielectric spectroscopy (DS) into a stirred tank reactor to characterize the Measles virus production process in adherent growing Vero cells. We found that DS could be used to monitor cell adhesion on the microcarrier and that the optimal virus harvest time correlated with the global maximum permittivity signal. In 16 independent bioreactor runs, the maximum Measles virus titer was achieved approximately 40 hr after the permittivity maximum. Compared to an uncontrolled Measles virus production process, the integration of DS increased the maximum virus concentration by more than three orders of magnitude. This was sufficient to achieve an active Measles virus concentration of > 10 10 TCID 50 ml -1 . © 2017 Wiley Periodicals, Inc.

  11. Optimization of a High Temperature PEMFC micro-CHP System by Formulation and Application of a Process Integration Methodology

    DEFF Research Database (Denmark)

    Arsalis, Alexandros; Nielsen, Mads Pagh; Kær, Søren Knudsen

    2013-01-01

    A 1 kWe micro combined heat and power (CHP) system based on high temperature proton exchange membrane fuel cell (PEMFC) technology is modeled and optimized by formulation and application of a process integration methodology. The system can provide heat and electricity for a singlefamily household...

  12. Development of integrated control system for smart factory in the injection molding process

    Science.gov (United States)

    Chung, M. J.; Kim, C. Y.

    2018-03-01

    In this study, we proposed integrated control system for automation of injection molding process required for construction of smart factory. The injection molding process consists of heating, tool close, injection, cooling, tool open, and take-out. Take-out robot controller, image processing module, and process data acquisition interface module are developed and assembled to integrated control system. By adoption of integrated control system, the injection molding process can be simplified and the cost for construction of smart factory can be inexpensive.

  13. Systematic Integrated Process Design and Control of Binary Element Reactive Distillation Processes

    DEFF Research Database (Denmark)

    Mansouri, Seyed Soheil; Sales-Cruz, Mauricio; Huusom, Jakob Kjøbsted

    2016-01-01

    In this work, integrated process design and control of reactive distillation processes is considered through a computer-aided framework. First, a set of simple design methods for reactive distillation column that are similar in concept to non-reactive distillation design methods are extended...... to design-control of reactive distillation columns. These methods are based on the element concept where the reacting system of compounds is represented as elements. When only two elements are needed to represent the reacting system of more than two compounds, a binary element system is identified....... It is shown that the same design-control principles that apply to a non-reacting binary system of compounds are also valid for a reactive binary system of elements for distillation columns. Application of this framework shows that designing the reactive distillation process at the maximum driving force...

  14. Model-Based Integrated Process Design and Controller Design of Chemical Processes

    DEFF Research Database (Denmark)

    Abd Hamid, Mohd Kamaruddin Bin

    that is typically formulated as a mathematical programming (optimization with constraints) problem is solved by the so-called reverse approach by decomposing it into four sequential hierarchical sub-problems: (i) pre-analysis, (ii) design analysis, (iii) controller design analysis, and (iv) final selection......This thesis describes the development and application of a new systematic modelbased methodology for performing integrated process design and controller design (IPDC) of chemical processes. The new methodology is simple to apply, easy to visualize and efficient to solve. Here, the IPDC problem...... are ordered according to the defined performance criteria (objective function). The final selected design is then verified through rigorous simulation. In the pre-analysis sub-problem, the concepts of attainable region and driving force are used to locate the optimal process-controller design solution...

  15. A Multi-Objective Optimization Method to integrate Heat Pumps in Industrial Processes

    OpenAIRE

    Becker, Helen; Spinato, Giulia; Maréchal, François

    2011-01-01

    Aim of process integration methods is to increase the efficiency of industrial processes by using pinch analysis combined with process design methods. In this context, appropriate integrated utilities offer promising opportunities to reduce energy consumption, operating costs and pollutants emissions. Energy integration methods are able to integrate any type of predefined utility, but so far there is no systematic approach to generate potential utilities models based on their technology limit...

  16. Process development for high-efficiency silicon solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Gee, J.M.; Basore, P.A.; Buck, M.E.; Ruby, D.S.; Schubert, W.K.; Silva, B.L.; Tingley, J.W.

    1991-12-31

    Fabrication of high-efficiency silicon solar cells in an industrial environment requires a different optimization than in a laboratory environment. Strategies are presented for process development of high-efficiency silicon solar cells, with a goal of simplifying technology transfer into an industrial setting. The strategies emphasize the use of statistical experimental design for process optimization, and the use of baseline processes and cells for process monitoring and quality control. 8 refs.

  17. Using CORBA to integrate manufacturing cells to a virtual enterprise

    Science.gov (United States)

    Pancerella, Carmen M.; Whiteside, Robert A.

    1997-01-01

    It is critical in today's enterprises that manufacturing facilities are not isolated from design, planning, and other business activities and that information flows easily and bidirectionally between these activities. It is also important and cost-effective that COTS software, databases, and corporate legacy codes are well integrated in the information architecture. Further, much of the information generated during manufacturing must be dynamically accessible to engineering and business operations both in a restricted corporate intranet and on the internet. The software integration strategy in the Sandia Agile Manufacturing Testbed supports these enterprise requirements. We are developing a CORBA-based distributed object software system for manufacturing. Each physical machining device is a CORBA object and exports a common IDL interface to allow for rapid and dynamic insertion, deletion, and upgrading within the manufacturing cell. Cell management CORBA components access manufacturing devices without knowledge of any device-specific implementation. To support information flow from design to planning data is accessible to machinists on the shop floor. CORBA allows manufacturing components to be easily accessible to the enterprise. Dynamic clients can be created using web browsers and portable Java GUI's. A CORBA-OLE adapter allows integration to PC desktop applications. Other commercial software can access CORBA network objects in the information architecture through vendor API's.

  18. Integrable dissipative exclusion process: Correlation functions and physical properties

    Science.gov (United States)

    Crampe, N.; Ragoucy, E.; Rittenberg, V.; Vanicat, M.

    2016-09-01

    We study a one-parameter generalization of the symmetric simple exclusion process on a one-dimensional lattice. In addition to the usual dynamics (where particles can hop with equal rates to the left or to the right with an exclusion constraint), annihilation and creation of pairs can occur. The system is driven out of equilibrium by two reservoirs at the boundaries. In this setting the model is still integrable: it is related to the open XXZ spin chain through a gauge transformation. This allows us to compute the full spectrum of the Markov matrix using Bethe equations. We also show that the stationary state can be expressed in a matrix product form permitting to compute the multipoints correlation functions as well as the mean value of the lattice and the creation-annihilation currents. Finally, the variance of the lattice current is computed for a finite-size system. In the thermodynamic limit, it matches the value obtained from the associated macroscopic fluctuation theory.

  19. BEHAVIOR OF MERCURY DURING DWPF CHEMICAL PROCESS CELL PROCESSING

    Energy Technology Data Exchange (ETDEWEB)

    Zamecnik, J.; Koopman, D.

    2012-04-09

    The Defense Waste Processing Facility has experienced significant issues with the stripping and recovery of mercury in the Chemical Processing Cell (CPC). The stripping rate has been inconsistent, often resulting in extended processing times to remove mercury to the required endpoint concentration. The recovery of mercury in the Mercury Water Wash Tank has never been high, and has decreased significantly since the Mercury Water Wash Tank was replaced after the seventh batch of Sludge Batch 5. Since this time, essentially no recovery of mercury has been seen. Pertinent literature was reviewed, previous lab-scale data on mercury stripping and recovery was examined, and new lab-scale CPC Sludge Receipt and Adjustment Tank (SRAT) runs were conducted. For previous lab-scale data, many of the runs with sufficient mercury recovery data were examined to determine what factors affect the stripping and recovery of mercury and to improve closure of the mercury material balance. Ten new lab-scale SRAT runs (HG runs) were performed to examine the effects of acid stoichiometry, sludge solids concentration, antifoam concentration, form of mercury added to simulant, presence of a SRAT heel, operation of the SRAT condenser at higher than prototypic temperature, varying noble metals from none to very high concentrations, and higher agitation rate. Data from simulant runs from SB6, SB7a, glycolic/formic, and the HG tests showed that a significant amount of Hg metal was found on the vessel bottom at the end of tests. Material balance closure improved from 12-71% to 48-93% when this segregated Hg was considered. The amount of Hg segregated as elemental Hg on the vessel bottom was 4-77% of the amount added. The highest recovery of mercury in the offgas system generally correlated with the highest retention of Hg in the slurry. Low retention in the slurry (high segregation on the vessel bottom) resulted in low recovery in the offgas system. High agitation rates appear to result in lower

  20. Magnetic manipulation device for the optimization of cell processing conditions.

    Science.gov (United States)

    Ito, Hiroshi; Kato, Ryuji; Ino, Kosuke; Honda, Hiroyuki

    2010-02-01

    Variability in human cell phenotypes make it's advancements in optimized cell processing necessary for personalized cell therapy. Here we propose a strategy of palm-top sized device to assist physically manipulating cells for optimizing cell preparations. For the design of such a device, we combined two conventional approaches: multi-well plate formatting and magnetic cell handling using magnetite cationic liposomes (MCLs). From our previous works, we showed the labeling applications of MCL on adhesive cells for various tissue engineering approaches. To feasibly transfer cells in multi-well plate, we here evaluated the magnetic response of MCL-labeled suspension type cells. The cell handling performance of Jurkat cells proved to be faster and more robust compared to MACS (Magnetic Cell Sorting) bead methods. To further confirm our strategy, prototype palm-top sized device "magnetic manipulation device (MMD)" was designed. In the device, the actual cell transportation efficacy of Jurkat cells was satisfying. Moreover, as a model of the most distributed clinical cell processing, primary peripheral blood mononuclear cells (PBMCs) from different volunteers were evaluated. By MMD, individual PBMCs indicated to have optimum Interleukin-2 (IL-2) concentrations for the expansion. Such huge differences of individual cells indicated that MMD, our proposing efficient and self-contained support tool, could assist the feasible and cost-effective optimization of cell processing in clinical facilities. Copyright (c) 2009 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  1. Jenkins-CI, an Open-Source Continuous Integration System, as a Scientific Data and Image-Processing Platform

    Science.gov (United States)

    Moutsatsos, Ioannis K.; Hossain, Imtiaz; Agarinis, Claudia; Harbinski, Fred; Abraham, Yann; Dobler, Luc; Zhang, Xian; Wilson, Christopher J.; Jenkins, Jeremy L.; Holway, Nicholas; Tallarico, John; Parker, Christian N.

    2016-01-01

    High-throughput screening generates large volumes of heterogeneous data that require a diverse set of computational tools for management, processing, and analysis. Building integrated, scalable, and robust computational workflows for such applications is challenging but highly valuable. Scientific data integration and pipelining facilitate standardized data processing, collaboration, and reuse of best practices. We describe how Jenkins-CI, an “off-the-shelf,” open-source, continuous integration system, is used to build pipelines for processing images and associated data from high-content screening (HCS). Jenkins-CI provides numerous plugins for standard compute tasks, and its design allows the quick integration of external scientific applications. Using Jenkins-CI, we integrated CellProfiler, an open-source image-processing platform, with various HCS utilities and a high-performance Linux cluster. The platform is web-accessible, facilitates access and sharing of high-performance compute resources, and automates previously cumbersome data and image-processing tasks. Imaging pipelines developed using the desktop CellProfiler client can be managed and shared through a centralized Jenkins-CI repository. Pipelines and managed data are annotated to facilitate collaboration and reuse. Limitations with Jenkins-CI (primarily around the user interface) were addressed through the selection of helper plugins from the Jenkins-CI community. PMID:27899692

  2. Jenkins-CI, an Open-Source Continuous Integration System, as a Scientific Data and Image-Processing Platform.

    Science.gov (United States)

    Moutsatsos, Ioannis K; Hossain, Imtiaz; Agarinis, Claudia; Harbinski, Fred; Abraham, Yann; Dobler, Luc; Zhang, Xian; Wilson, Christopher J; Jenkins, Jeremy L; Holway, Nicholas; Tallarico, John; Parker, Christian N

    2017-03-01

    High-throughput screening generates large volumes of heterogeneous data that require a diverse set of computational tools for management, processing, and analysis. Building integrated, scalable, and robust computational workflows for such applications is challenging but highly valuable. Scientific data integration and pipelining facilitate standardized data processing, collaboration, and reuse of best practices. We describe how Jenkins-CI, an "off-the-shelf," open-source, continuous integration system, is used to build pipelines for processing images and associated data from high-content screening (HCS). Jenkins-CI provides numerous plugins for standard compute tasks, and its design allows the quick integration of external scientific applications. Using Jenkins-CI, we integrated CellProfiler, an open-source image-processing platform, with various HCS utilities and a high-performance Linux cluster. The platform is web-accessible, facilitates access and sharing of high-performance compute resources, and automates previously cumbersome data and image-processing tasks. Imaging pipelines developed using the desktop CellProfiler client can be managed and shared through a centralized Jenkins-CI repository. Pipelines and managed data are annotated to facilitate collaboration and reuse. Limitations with Jenkins-CI (primarily around the user interface) were addressed through the selection of helper plugins from the Jenkins-CI community.

  3. Optimization of an integrated electrodisinfection/electrocoagulation process with Al bipolar electrodes for urban wastewater reclamation.

    Science.gov (United States)

    Cotillas, Salvador; Llanos, Javier; Cañizares, Pablo; Mateo, Sara; Rodrigo, Manuel A

    2013-04-01

    In this work, a novel integrated electrochemical process for urban wastewater regeneration is described. The electrochemical cell consists in a Boron Doped Diamond (BDD) or a Dimensionally Stable Anode (DSA) as anode, a Stainless Steel (SS) as cathode and a perforated aluminum plate, which behaves as bipolar electrode, between anode and cathode. Thus, in this cell, it is possible to carry out, at the same time, two different electrochemical processes: electrodisinfection (ED) and electrocoagulation (EC). The treatment of urban wastewater with different anodes and different operating conditions is studied. First of all, in order to check the process performance, experiments with synthetic wastewaters were carried out, showing that it is possible to achieve a 100% of turbidity removal by the electrodissolution of the bipolar electrode. Next, the effect of the current density and the anode material are studied during the ED-EC process of actual effluents. Results show that it is possible to remove Escherichia coli and turbidity simultaneously of an actual effluent from a WasteWater Treatment Facility (WWTF). The use of BDD anodes allows to remove the E. coli completely at an applied electric charge of 0.0077 A h dm(-3) when working with a current density of 6.65 A m(-2). On the other hand, with DSA anodes, the current density necessary to achieve the total removal of E. coli is higher (11.12 A m(-2)) than that required with BDD anodes. Finally, the influence of cell flow path and flow rate have been studied. Results show that the performance of the process strongly depends on the characteristics of the initial effluent (E. coli concentration and Cl(-)/NH(4)(+) initial ratio) and that a cell configuration cathode (inlet)-anode (outlet) and a higher flow rate enhance the removal of the turbidity from the treated effluent. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. An analysis of the perceived difficulties arising during the process of integrating management systems

    Directory of Open Access Journals (Sweden)

    Jesus Abad

    2016-09-01

    Originality/value: Most research emphasises the benefits of integrated management systems. By analysing the difficulties that arise during the integration process, this study contributes to fill a gap in the literature on the problems associated with processes of organisational change, in our case the integration of management systems.

  5. On stochastic integration for volatility modulated Brownian-driven Volterra processes via white noise analysis

    DEFF Research Database (Denmark)

    E. Barndorff-Nielsen, Ole; Benth, Fred Espen; Szozda, Benedykt

    This paper generalizes the integration theory for volatility modulated Brownian-driven Volterra processes onto the space G* of Potthoff-Timpel distributions. Sufficient conditions for integrability of generalized processes are given, regularity results and properties of the integral are discussed...

  6. On stochastic integration for volatility modulated Brownian-driven Volterra processes via white noise analysis

    DEFF Research Database (Denmark)

    Barndorff-Nielsen, Ole E.; Benth, Fred Espen; Szozda, Benedykt

    This paper generalizes the integration theory for volatility modulated Brownian-driven Volterra processes onto the space G∗ of Potthoff--Timpel distributions. Sufficient conditions for integrability of generalized processes are given, regularity results and properties of the integral are discusse...

  7. Pericellular oxygen monitoring with integrated sensor chips for reproducible cell culture experiments.

    Science.gov (United States)

    Kieninger, J; Aravindalochanan, K; Sandvik, J A; Pettersen, E O; Urban, G A

    2014-04-01

    Here we present an application, in two tumour cell lines, based on the Sensing Cell Culture Flask system as a cell culture monitoring tool for pericellular oxygen sensing. T-47D (human breast cancer) and T98G (human brain cancer) cells were cultured either in atmospheric air or in a glove-box set at 4% oxygen, in both cases with 5% CO2 in the gas phase. Pericellular oxygen tension was measured with the help of an integrated sensor chip comprising oxygen sensor arrays. Obtained results illustrate variation of pericellular oxygen tension in attached cells covered by stagnant medium. Independent of incubation conditions, low pericellular oxygen concentration levels, usually associated with hypoxia, were found in dense cell cultures. Respiration alone brought pericellular oxygen concentration down to levels which could activate hypoxia-sensing regulatory processes in cultures believed to be aerobic. Cells in culture believed to experience conditions of mild hypoxia may, in reality, experience severe hypoxia. This would lead to incorrect assumptions and suggests that pericellular oxygen concentration readings are of great importance to obtain reproducible results when dealing with hypoxic and normoxic (aerobic) incubation conditions. The Sensing Cell Culture Flask system allows continuous monitoring of pericellular oxygen concentration with outstanding long-term stability and no need for recalibration during cell culture experiments. The sensor is integrated into the flask bottom, thus in direct contact with attached cells. No additional equipment needs to be inserted into the flask during culturing. Transparency of the electrochemical sensor chip allows optical inspection of cells attached on top of the sensor. © 2014 John Wiley & Sons Ltd.

  8. An integrated domain specific language for post-processing and visualizing electrophysiological signals in Java.

    Science.gov (United States)

    Strasser, T; Peters, T; Jagle, H; Zrenner, E; Wilke, R

    2010-01-01

    Electrophysiology of vision - especially the electroretinogram (ERG) - is used as a non-invasive way for functional testing of the visual system. The ERG is a combined electrical response generated by neural and non-neuronal cells in the retina in response to light stimulation. This response can be recorded and used for diagnosis of numerous disorders. For both clinical practice and clinical trials it is important to process those signals in an accurate and fast way and to provide the results as structured, consistent reports. Therefore, we developed a freely available and open-source framework in Java (http://www.eye.uni-tuebingen.de/project/idsI4sigproc). The framework is focused on an easy integration with existing applications. By leveraging well-established software patterns like pipes-and-filters and fluent interfaces as well as by designing the application programming interfaces (API) as an integrated domain specific language (DSL) the overall framework provides a smooth learning curve. Additionally, it already contains several processing methods and visualization features and can be extended easily by implementing the provided interfaces. In this way, not only can new processing methods be added but the framework can also be adopted for other areas of signal processing. This article describes in detail the structure and implementation of the framework and demonstrate its application through the software package used in clinical practice and clinical trials at the University Eye Hospital Tuebingen one of the largest departments in the field of visual electrophysiology in Europe.

  9. Science Integrating Learning Objectives: A Cooperative Learning Group Process

    Science.gov (United States)

    Spindler, Matt

    2015-01-01

    The integration of agricultural and science curricular content that capitalizes on natural and inherent connections represents a challenge for secondary agricultural educators. The purpose of this case study was to create information about the employment of Cooperative Learning Groups (CLG) to enhance the science integrating learning objectives…

  10. Integrated management of information inside maintenance processes. From the building registry to BIM systems

    Directory of Open Access Journals (Sweden)

    Cinzia Talamo

    2014-10-01

    Full Text Available The paper presents objec- tives, methods and results of two researches dealing with the improvement of integrated information management within maintenance processes. Focusing on information needs regarding the last phases of the building process, the two researches draft approaches characterizing a path of progressive improve- ment of strategies for integration: from a building registry, unique for the whole construction process, to an integrated management of the building process with the support of BIM systems.

  11. Fuel Cell Stations Automate Processes, Catalyst Testing

    Science.gov (United States)

    2010-01-01

    Glenn Research Center looks for ways to improve fuel cells, which are an important source of power for space missions, as well as the equipment used to test fuel cells. With Small Business Innovation Research (SBIR) awards from Glenn, Lynntech Inc., of College Station, Texas, addressed a major limitation of fuel cell testing equipment. Five years later, the company obtained a patent and provided the equipment to the commercial world. Now offered through TesSol Inc., of Battle Ground, Washington, the technology is used for fuel cell work, catalyst testing, sensor testing, gas blending, and other applications. It can be found at universities, national laboratories, and businesses around the world.

  12. Life-cycle analysis of product integrated polymer solar cells

    DEFF Research Database (Denmark)

    Espinosa Martinez, Nieves; García-Valverde, Rafael; Krebs, Frederik C

    2011-01-01

    A life cycle analysis (LCA) on a product integrated polymer solar module is carried out in this study. These assessments are well-known to be useful in developmental stages of a product in order to identify the bottlenecks for the up-scaling in its production phase for several aspects spanning from...... economics through design to functionality. An LCA study was performed to quantify the energy use and greenhouse gas (GHG) emissions from electricity use in the manufacture of a light-weight lamp based on a plastic foil, a lithium-polymer battery, a polymer solar cell, printed circuitry, blocking diode......, switch and a white light emitting semiconductor diode. The polymer solar cell employed in this prototype presents a power conversion efficiency in the range of 2 to 3% yielding energy payback times (EPBT) in the range of 1.3–2 years. Based on this it is worthwhile to undertake a life-cycle study...

  13. Recombinant Protein Production and Insect Cell Culture and Process

    Science.gov (United States)

    Spaulding, Glenn F. (Inventor); Goodwin, Thomas J. (Inventor); OConnor, Kim C. (Inventor); Francis, Karen M. (Inventor); Andrews, Angela D. (Inventor); Prewett, Tracey L. (Inventor)

    1997-01-01

    A process has been developed for recombinant production of selected polypeptides using transformed insect cells cultured in a horizontally rotating culture vessel modulated to create low shear conditions. A metabolically transformed insect cell line is produced using the culture procedure regardless of genetic transformation. The recombinant polypeptide can be produced by an alternative process using virtually infected or stably transformed insect cells containing a gene encoding the described polypeptide. The insect cells can also be a host for viral production.

  14. Integrated Transcriptomic and Epigenomic Analysis of Primary Human Lung Epithelial Cell Differentiation

    Science.gov (United States)

    Marconett, Crystal N.; Zhou, Beiyun; Rieger, Megan E.; Selamat, Suhaida A.; Dubourd, Mickael; Fang, Xiaohui; Lynch, Sean K.; Stueve, Theresa Ryan; Siegmund, Kimberly D.; Berman, Benjamin P.

    2013-01-01

    Elucidation of the epigenetic basis for cell-type specific gene regulation is key to gaining a full understanding of how the distinct phenotypes of differentiated cells are achieved and maintained. Here we examined how epigenetic changes are integrated with transcriptional activation to determine cell phenotype during differentiation. We performed epigenomic profiling in conjunction with transcriptomic profiling using in vitro differentiation of human primary alveolar epithelial cells (AEC). This model recapitulates an in vivo process in which AEC transition from one differentiated cell type to another during regeneration following lung injury. Interrogation of histone marks over time revealed enrichment of specific transcription factor binding motifs within regions of changing chromatin structure. Cross-referencing of these motifs with pathways showing transcriptional changes revealed known regulatory pathways of distal alveolar differentiation, such as the WNT and transforming growth factor beta (TGFB) pathways, and putative novel regulators of adult AEC differentiation including hepatocyte nuclear factor 4 alpha (HNF4A), and the retinoid X receptor (RXR) signaling pathways. Inhibition of the RXR pathway confirmed its functional relevance for alveolar differentiation. Our incorporation of epigenetic data allowed specific identification of transcription factors that are potential direct upstream regulators of the differentiation process, demonstrating the power of this approach. Integration of epigenomic data with transcriptomic profiling has broad application for the identification of regulatory pathways in other models of differentiation. PMID:23818859

  15. Social networks in nursing work processes: an integrative literature review.

    Science.gov (United States)

    Mesquita, Ana Cláudia; Zamarioli, Cristina Mara; Fulquini, Francine Lima; Carvalho, Emilia Campos de; Angerami, Emilia Luigia Saporiti

    2017-03-20

    To identify and analyze the available evidence in the literature on the use of social networks in nursing work processes. An integrative review of the literature conducted in PubMed, CINAHL, EMBASE and LILACS databases in January 2016, using the descriptors social media, social networking, nursing, enfermagem, redes sociais, mídias sociais, and the keyword nursing practice, without year restriction. The sample consisted of 27 international articles which were published between 2011 and 2016. The social networks used were Facebook (66.5%), Twitter (30%) and WhatsApp (3.5%). In 70.5% of the studies, social networks were used for research purposes, in 18.5% they were used as a tool aimed to assist students in academic activities, and in 11% for executing interventions via the internet. Nurses have used social networks in their work processes such as Facebook, Twitter and WhatsApp to research, teach and watch. The articles show several benefits in using such tools in the nursing profession; however, ethical considerations regarding the use of social networks deserve further discussion. Identificar e analisar as evidências disponíveis na literatura sobre a utilização de redes sociais nos processos de trabalho em enfermagem. Revisão integrativa da literatura realizada em janeiro de 2016, nas bases de dados PubMed, CINAHL, EMBASE e LILACS, com os descritores social media, social networking, nursing, enfermagem, redes sociais, mídias sociais e a palavra-chave nursing practice, sem restrição de ano. A amostra foi composta por 27 artigos, os quais foram publicados entre 2011 e 2016, todos internacionais. As redes sociais utilizadas foram o Facebook (66,5%), o Twitter (30%) e o WhatsApp (3,5%). Em 70,5% dos estudos as redes sociais foram utilizadas para fins de pesquisa, em 18,5% como ferramenta para auxiliar estudantes nas atividades acadêmicas, e em 11% para a realização de intervenções via internet. Em seus processos de trabalho, os enfermeiros têm utilizado

  16. Towards an Evaluation Framework for Business Process Integration and Management

    NARCIS (Netherlands)

    Mutschler, B.B.; Reichert, M.U.; Bumiller, J.

    2005-01-01

    Process-awareness in enterprise computing is a must in order to adequately support business processes. Particularly the interoperability of the (process-oriented) business information systems and the management of a company’s process map are difficult to handle. Process-oriented approaches (like

  17. Gallium Phosphide Integrated with Silicon Heterojunction Solar Cells

    Science.gov (United States)

    Zhang, Chaomin

    It has been a long-standing goal to epitaxially integrate III-V alloys with Si substrates which can enable low-cost microelectronic and optoelectronic systems. Among the III-V alloys, gallium phosphide (GaP) is a strong candidate, especially for solar cells applications. Gallium phosphide with small lattice mismatch ( 0.4%) to Si enables coherent/pseudomorphic epitaxial growth with little crystalline defect creation. The band offset between Si and GaP suggests that GaP can function as an electron-selective contact, and it has been theoretically shown that GaP/Si integrated solar cells have the potential to overcome the limitations of common a-Si based heterojunction (SHJ) solar cells. Despite the promising potential of GaP/Si heterojunction solar cells, there are two main obstacles to realize high performance photovoltaic devices from this structure. First, the growth of the polar material (GaP) on the non-polar material (Si) is a challenge in how to suppress the formation of structural defects, such as anti-phase domains (APD). Further, it is widely observed that the minority-carrier lifetime of the Si substrates is significantly decreased during epitaxially growth of GaP on Si. In this dissertation, two different GaP growth methods were compared and analyzed, including migration-enhanced epitaxy (MEE) and traditional molecular beam epitaxy (MBE). High quality GaP can be realized on precisely oriented (001) Si substrates by MBE growth, and the investigation of structural defect creation in the GaP/Si epitaxial structures was conducted using high resolution X-ray diffraction (HRXRD) and high resolution transmission electron microscopy (HRTEM). The mechanisms responsible for lifetime degradation were further investigated, and it was found that external fast diffusors are the origin for the degradation. Two practical approaches including the use of both a SiNx diffusion barrier layer and P-diffused layers, to suppress the Si minority-carrier lifetime degradation

  18. An integrated architecture for shallow and deep processing

    OpenAIRE

    Crysmann, Berthold; Frank, Anette; Kiefer, Bernd; Müller, Stefan; Neumann, Günter; Piskorski, Jakub; Schäfer, Ulrich; Siegel, Melanie; Uszkoreit, Hans; Xu, Feiyu; Becker, Markus; Krieger, Hans-Ulrich

    2011-01-01

    We present an architecture for the integration of shallow and deep NLP components which is aimed at flexible combination of different language technologies for a range of practical current and future applications. In particular, we describe the integration of a high-level HPSG parsing system with different high-performance shallow components, ranging from named entity recognition to chunk parsing and shallow clause recognition. The NLP components enrich a representation of natural language te...

  19. Periodic nanostructures on unpolished substrates and their integration in solar cells

    International Nuclear Information System (INIS)

    Cornago, I; Dominguez, S; Bravo, J; Ezquer, M; Rodríguez, M J; Lagunas, A R; Pérez-Conde, J; Rodriguez, R

    2015-01-01

    We present a novel fabrication process based on laser interference lithography, lift-off and reactive ion etching, which allows us to fabricate periodic nanostructures on photovoltaic substrates with an average root mean square (RMS) roughness of 750 nm. We fabricate nanostructures on unpolished crystalline silicon substrates, which reduces their reflectance 30% as fabricated. When an additional passivation layer is deposited, the light trapping grows, achieving a reflectance reduction of 60%. In addition, we have successfully integrated the nanostructured substrates in silicon wafer–based solar cells following standard processes, achieving a final efficiency of 15.56%. (paper)

  20. Advanced laser processing for industrial solar cell manufacturing (ALPINISM)

    Energy Technology Data Exchange (ETDEWEB)

    Mason, N.B.; Fieret, J. [Exitech Ltd. (United Kingdom)

    2006-05-04

    The study was aimed at improving methods for the manufacture of high efficiency solar cells and thereby increase production rates. The project focused on the laser grooved buried contact solar cell (LGBC) which is produced by high-speed laser machining. The specific objectives were (i) to optimise the laser technology for high speed processing; (ii) to optimise the solar cell process conditions for high speed processing; (iii) to produce a prototype tool and demonstrate high throughput; and (iv) to demonstrate increased cell efficiency using laser processing of rear contact. Essentially, all the objectives were met and Exitech have already sold six production tools and one research tool developed in this study. In addition, it was found that laser processing at the rear cell surface offers the prospect of LGBC solar cells with an efficiency of 20 per cent. BP Solar Limited carried out this work under contract to the DTI.

  1. SYSTEM AND PROCESS FOR PRODUCTION OF METHANOL FROM COMBINED WIND TURBINE AND FUEL CELL POWER

    Science.gov (United States)

    The paper examines an integrated use of ultra-clean wind turbines and high temperature fuel cells to produce methanol, especially for transportation purposes. The principal utility and application of the process is the production of transportation fuel from domestic resources to ...

  2. Trends And Economic Assessment Of Integration Processes At The Metal Market

    Directory of Open Access Journals (Sweden)

    Olga Aleksandrovna Romanova

    2015-03-01

    Full Text Available The article discussed the integration process from the perspective of three dimensions that characterize the corresponding increase in the number and appearance of new relationships; strength, character, and stability of emerging communications; dynamics and the appropriate form of the process. In the article, trends of development of integration processes in metallurgy are identified, identification of five stages of development in Russian metal trading are justified. We propose a step by step way to implement the integration process, developed a methodical approach to assessing the feasibility of economic integration processes steel producers and steel traders, including three consecutive stages of its implementing respectively, the principles of reflexive control, entropy approach, the traditional assessment of mergers and acquisitions. The algorithm for the practical realization of the author’s approach, which allows to identify the optimal trajectory of the integration process as a series of horizontal and vertical integration steps is developed.

  3. The Integration of Extrarational and Rational Learning Processes: Moving Towards the Whole Learner.

    Science.gov (United States)

    Puk, Tom

    1996-01-01

    Discusses the dichotomy between rational and nonrational learning processes, arguing for an integration of both. Reviews information processing theory and related learning strategies. Presents a model instructional strategy that fully integrates rational and nonrational processes. Describes implications for teaching and learning of the learning…

  4. Integration Processes of Delay Differential Equation Based on Modified Laguerre Functions

    Directory of Open Access Journals (Sweden)

    Yeguo Sun

    2012-01-01

    Full Text Available We propose long-time convergent numerical integration processes for delay differential equations. We first construct an integration process based on modified Laguerre functions. Then we establish its global convergence in certain weighted Sobolev space. The proposed numerical integration processes can also be used for systems of delay differential equations. We also developed a technique for refinement of modified Laguerre-Radau interpolations. Lastly, numerical results demonstrate the spectral accuracy of the proposed method and coincide well with analysis.

  5. Integrating deep and shallow natural language processing components : representations and hybrid architectures

    OpenAIRE

    Schäfer, Ulrich

    2006-01-01

    We describe basic concepts and software architectures for the integration of shallow and deep (linguistics-based, semantics-oriented) natural language processing (NLP) components. The main goal of this novel, hybrid integration paradigm is improving robustness of deep processing. After an introduction to constraint-based natural language parsing, we give an overview of typical shallow processing tasks. We introduce XML standoff markup as an additional abstraction layer that eases integration ...

  6. Cell kinetics, DNA integrity, differentiation, and lipid fingerprinting analysis of rabbit adipose-derived stem cells.

    Science.gov (United States)

    Barretto, Letícia Siqueira de Sá; Lessio, Camila; Sawaki e Nakamura, Ahy Natally; Lo Turco, Edson Guimarães; da Silva, Camila Gonzaga; Zambon, João Paulo; Gozzo, Fábio César; Pilau, Eduardo Jorge; de Almeida, Fernando Gonçalves

    2014-10-01

    Human adipose tissue has been described as a potential alternative reservoir for stem cells. Although studies have been performed in rabbits using autologous adipose-derived stem cells (ADSC), these cells have not been well characterized. The primary objectives of this study were to demonstrate the presence of adipose-derived stem cells isolated from rabbit inguinal fat pads and to characterize them through osteogenic and adipogenic in vitro differentiation and lipid fingerprinting analysis. The secondary objective was to evaluate cell behavior through growth kinetics, cell viability, and DNA integrity. Rabbit ADSCs were isolated to determine the in vitro growth kinetics and cell viability. DNA integrity was assessed by an alkaline Comet assay in passages 0 and 5. The osteogenic differentiation was evaluated by Von Kossa, and Alizarin Red S staining and adipogenic differentiation were assessed by Oil Red O staining. Lipid fingerprinting analyses of control, adipogenic, and osteogenic differentiated cells were performed by MALDI-TOF/MS. We demonstrate that rabbit ADSC have a constant growth rate at the early passages, with increased DNA fragmentation at or after passage 5. Rabbit ADSC viability was similar in passages 2 and 5 (90.7% and 86.6%, respectively), but there was a tendency to decreased cellular growth rate after passage 3. The ADSC were characterized by the expression of surface markers such as CD29 (67.4%) and CD44 (89.4%), using CD 45 (0.77%) as a negative control. ADSC from rabbits were successfully isolated form the inguinal region. These cells were capable to differentiate into osteogenic and adipogenic tissue when they were placed in inductive media. After each passage, there was a trend towards decreased cell growth. On the other hand, DNA fragmentation increased at each passage. ADSC had a different lipid profile when placed in control, adipogenic, or osteogenic media.

  7. Integrated fuel cell energy system for modern buildings

    Energy Technology Data Exchange (ETDEWEB)

    Moard, D.M.; Cuzens, J.E.

    1998-07-01

    Energy deregulation, building design efficiency standards and competitive pressures all encourage the incorporation of distributed fuel cell cogeneration packages into modern buildings. The building marketplace segments to which these systems apply include office buildings, retail stores, hospitals, hotels, food service and multifamily residences. These applications represent approximately 60% of the commercial building sector's energy use plus a portion of the residential sector's energy use. While there are several potential manufacturers of fuel cells on the verge of marketing equipment, most are currently using commercial hydrogen gas to fuel them. There are few suppliers of equipment, which convert conventional fuels into hydrogen. Hydrogen Burner Technology, Inc. (HBT) is one of the few companies with a proven under-oxidized-burner (UOB) technology, patented and already proven in commercial use for industrial applications. HBT is developing a subsystem based on the UOB technology that can produce a hydrogen rich product gas using natural gas, propane or liquid fuels as the feed stock, which may be directly useable by proton exchange membrane (PEM) fuel cells for conversion into electricity. The combined thermal output can also be used for space heating/cooling, water heating or steam generation applications. HBT is currently analyzing the commercial building market, integrated system designs and marketplace motivations which will allow the best overall subsystem to be designed, tested and introduced commercially in the shortest time possible. HBT is also actively involved in combined subsystem designs for use in automotive and small residential services.

  8. Analysis of Fleet Readiness Center Southwest Concept Integration: New-Employee Orientation and Communication Processes

    National Research Council Canada - National Science Library

    Clemmons, Francini R; Falconieri, Holly M

    2007-01-01

    Fleet Readiness Center Southwest has embraced integration of personnel and processes from Aircraft Intermediate Maintenance Departments and Naval Aviation Depots supporting Naval Aviation Maintenance...

  9. SYSTEMS FOR IMPROVEMENT OF BUSINESS INTEGRATED MANAGEMENT PROCESSES IN PORTS

    Directory of Open Access Journals (Sweden)

    Pavle Popovic

    2017-03-01

    Full Text Available Based on test results obtained so far, the objective relating to modern scientific methods and approaches has been defined with the intention to develop model which defines new management system integration model, by adopting necessary practical terms of real systems that most frequently circulate in maritime practice in the field of integrated management systems (IMS in terms of safety and security of vessels and ports. The subject of research is maritime, particularly port services, by way of defining internal and external advantages through adopting integrated management systems. The research will be conducted through theoretical and applied assessments of case study analyses using example of the Port of Kotor H.Co.

  10. Transient processes in cell proliferation kinetics

    CERN Document Server

    Yakovlev, Andrej Yu

    1989-01-01

    A mathematician who has taken the romantic decision to devote himself to biology will doubtlessly look upon cell kinetics as the most simple and natural field of application for his knowledge and skills. Indeed, the thesaurus he is to master is not so complicated as, say, in molecular biology, the structural elements of the system, i. e. ceils, have been segregated by Nature itself, simple considerations of balance may be used for deducing basic equations, and numerous analogies in other areas of science also superficial add to one"s confidence. Generally speaking, this number of impression is correct, as evidenced by the very great theoretical studies on population kinetics, unmatched in other branches of mathematical biology. This, however, does not mean that mathematical theory of cell systems has traversed in its development a pathway free of difficulties or errors. The seeming ease of formalizing the phenomena of cell kinetics not infrequently led to the appearance of mathematical models lacking in adequ...

  11. Integration of solid oxide fuel cell (SOFC) and chemical looping combustion (CLC) for ultra-high efficiency power generation and CO2 production

    NARCIS (Netherlands)

    Spallina, Vincenzo; Nocerino, Pasquale; Romano, Matteo C.; van Sint Annaland, Martin; Campanari, Stefano; Gallucci, Fausto

    2018-01-01

    This work presents a thermodynamic analysis of the integration of solid oxide fuel cells (SOFCs) with chemical looping combustion (CLC) in natural gas power plants. The fundamental idea of the proposed process integration is to use a dual fluidized-bed CLC process to complete the oxidation of the

  12. Integrating statistical and process-based models to produce probabilistic landslide hazard at regional scale

    Science.gov (United States)

    Strauch, R. L.; Istanbulluoglu, E.

    2017-12-01

    We develop a landslide hazard modeling approach that integrates a data-driven statistical model and a probabilistic process-based shallow landslide model for mapping probability of landslide initiation, transport, and deposition at regional scales. The empirical model integrates the influence of seven site attribute (SA) classes: elevation, slope, curvature, aspect, land use-land cover, lithology, and topographic wetness index, on over 1,600 observed landslides using a frequency ratio (FR) approach. A susceptibility index is calculated by adding FRs for each SA on a grid-cell basis. Using landslide observations we relate susceptibility index to an empirically-derived probability of landslide impact. This probability is combined with results from a physically-based model to produce an integrated probabilistic map. Slope was key in landslide initiation while deposition was linked to lithology and elevation. Vegetation transition from forest to alpine vegetation and barren land cover with lower root cohesion leads to higher frequency of initiation. Aspect effects are likely linked to differences in root cohesion and moisture controlled by solar insulation and snow. We demonstrate the model in the North Cascades of Washington, USA and identify locations of high and low probability of landslide impacts that can be used by land managers in their design, planning, and maintenance.

  13. Managing uncertainty in fishing and processing of an integrated ...

    African Journals Online (AJOL)

    trawler scheduling, catch quota, processing and labour allocation, and inventory control. .... of trawlers, a number of processing plants and market requirements. ...... Norwegian University of Science and Technology, Trondheim, Norway.

  14. Impact of cell culture process changes on endogenous retrovirus expression.

    Science.gov (United States)

    Brorson, Kurt; De Wit, Christina; Hamilton, Elizabeth; Mustafa, Mehnaz; Swann, Patrick G; Kiss, Robert; Taticek, Ron; Polastri, Gian; Stein, Kathryn E; Xu, Yuan

    2002-11-05

    Cell culture process changes (e.g., changes in scale, medium formulation, operational conditions) and cell line changes are common during the development life cycle of a therapeutic protein. To ensure that the impact of such process changes on product quality and safety is minimal, it is standard practice to compare critical product quality and safety attributes before and after the changes. One potential concern introduced by cell culture process improvements is the possibility of increased endogenous retrovirus expression to a level above the clearance capability of the subsequent purification process. To address this, retrovirus expression was measured in scaled down and full production scaled Chinese hamster ovary (CHO) cell cultures of four monoclonal antibodies and one recombinant protein before and after process changes. Two highly sensitive, quantitative (Q)-PCR-based assays were used to measure endogenous retroviruses. It is shown that cell culture process changes that primarily alter media components, nutrient feed volume, seed density, cell bank source (i.e., master cell bank vs. working cell bank), and vial size, or culture scale, singly or in combination, do not impact the rate of retrovirus expression to an extent greater than the variability of the Q-PCR assays (0.2-0.5 log(10)). Cell culture changes that significantly alter the metabolic state of the cells and/or rates of protein expression (e.g., pH and temperature shifts, NaButyrate addition) measurably impact the rate of retrovirus synthesis (up to 2 log(10)). The greatest degree of variation in endogenous retrovirus expression was observed between individual cell lines (up to 3 log(10)). These data support the practice of measuring endogenous retrovirus output for each new cell line introduced into manufacturing or after process changes that significantly increase product-specific productivity or alter the metabolic state, but suggest that reassessment of retrovirus expression after other

  15. 324 Facility B-Cell quality process plan

    International Nuclear Information System (INIS)

    Carlson, J.L.

    1998-01-01

    This report documents the quality process plan for the restart of a hot cell in the B Plant, originally a bismuth phosphate processing facility, but later converted to a waste fractionation plant. B-Cell is currently being cleaned out and deactivated. TPA Milestone M-89-02 dictates that all mixed waste and equipment be removed from B-Cell by 5/31/1999. This report describes the major activities that remain for completion of the TPA milestone

  16. Deficits in Thematic Integration Processes in Broca's and Wernicke's Aphasia

    Science.gov (United States)

    Nakano, Hiroko; Blumstein, Sheila E.

    2004-01-01

    This study investigated how normal subjects and Broca's and Wernicke's aphasics integrate thematic information incrementally using syntax, lexical-semantics, and pragmatics in a simple active declarative sentence. Three priming experiments were conducted using an auditory lexical decision task in which subjects made a lexical decision on a…

  17. Mechanical integrity of PFHE in LNG liquefaction process

    NARCIS (Netherlands)

    Ligterink, N.E.; Hageraats-Ponomareva, S.V.; Velthuis, J.F.M.

    2012-01-01

    The mechanical integrity of heat exchangers is the result of an interplay of many physical phenomena. A full, albeit simple, model, that covers mixture phase thermodynamics, heat transfer, flow dynamics, and the thermal and pressure stresses has been created. Using this simulation model it is now

  18. Empathy: An Integral Model in the Counseling Process

    Science.gov (United States)

    Clark, Arthur J.

    2010-01-01

    Expanding on a framework introduced by Carl Rogers, an integral model of empathy in counseling uses empathic understanding through 3 ways of knowing: Subjective empathy enables a counselor to momentarily experience what it is like to be a client, interpersonal empathy relates to understanding a client's phenomenological experiencing, and objective…

  19. beta1 integrin maintains integrity of the embryonic neocortical stem cell niche.

    Directory of Open Access Journals (Sweden)

    Karine Loulier

    2009-08-01

    Full Text Available During embryogenesis, the neural stem cells (NSC of the developing cerebral cortex are located in the ventricular zone (VZ lining the cerebral ventricles. They exhibit apical and basal processes that contact the ventricular surface and the pial basement membrane, respectively. This unique architecture is important for VZ physical integrity and fate determination of NSC daughter cells. In addition, the shorter apical process is critical for interkinetic nuclear migration (INM, which enables VZ cell mitoses at the ventricular surface. Despite their importance, the mechanisms required for NSC adhesion to the ventricle are poorly understood. We have shown previously that one class of candidate adhesion molecules, laminins, are present in the ventricular region and that their integrin receptors are expressed by NSC. However, prior studies only demonstrate a role for their interaction in the attachment of the basal process to the overlying pial basement membrane. Here we use antibody-blocking and genetic experiments to reveal an additional and novel requirement for laminin/integrin interactions in apical process adhesion and NSC regulation. Transient abrogation of integrin binding and signalling using blocking antibodies to specifically target the ventricular region in utero results in abnormal INM and alterations in the orientation of NSC divisions. We found that these defects were also observed in laminin alpha2 deficient mice. More detailed analyses using a multidisciplinary approach to analyse stem cell behaviour by expression of fluorescent transgenes and multiphoton time-lapse imaging revealed that the transient embryonic disruption of laminin/integrin signalling at the VZ surface resulted in apical process detachment from the ventricular surface, dystrophic radial glia fibers, and substantial layering defects in the postnatal neocortex. Collectively, these data reveal novel roles for the laminin/integrin interaction in anchoring embryonic NSCs

  20. Integrating Copper Nanowire Electrodes for Low Temperature Perovskite Photovoltaic Cells

    Science.gov (United States)

    Mankowski, Trent

    Recent advances in third generation photovoltaics, particularly the rapid increase in perovskite power conversion efficiencies, may provide a cheap alternative to silicon solar cells in the near future. A key component to these devices is the transparent front electrode, and in the case of Dye Sensitized Solar Cells, it is the most expensive part. A lightweight, cost-effective, robust, and easy-to-fabricate new generation TCE is required to enable competition with silicon. Indium Tin Oxide, commonly used in touchscreen devices, Organic Light Emitting Diodes (OLEDs), and thin film photovoltaics, is widely used and commonly referred to as the industry standard. As the global supply of indium decreases and the demand for this TCE increases, a similar alternative TCE is required to accompany the next generation solar cells that promise energy with lighter and significantly cheaper modules. This alternative TCE needs to provide similar sheet resistance and optical transmittance to ITO, while also being mechanically and chemically robust. The work in this thesis begins with an exploration of several synthesized ITO replacement materials, such as copper nanowires, conductive polymer PEDOT:PSS, zinc oxide thin films, reduced graphene oxide and combinations of the above. A guiding philosophy to this work was prioritizing cheap, easy deposition methods and overall scalability. Shortcomings of these TCEs were investigated and different materials were hybridized to take advantage of each layers strengths for development of an ideal ITO replacement. For CuNW-based composite electrodes, 85% optical transmittance and 25 O/sq were observed and characterized to understand the underlying mechanisms for optimization. The second half of this work is an examination of many different perovskite synthesis methods first to achieve highest performance, and then to integrate compatible methods with our CuNW TCEs. Several literature methods investigated were irreproducible, and those that

  1. Electrical Impedance Spectroscopy for Detection of Cells in Suspensions Using Microfluidic Device with Integrated Microneedles

    Directory of Open Access Journals (Sweden)

    Muhammad Asraf Mansor

    2017-02-01

    Full Text Available In this study, we introduce novel method of flow cytometry for cell detection based on impedance measurements. The state of the art method for impedance flow cytometry detection utilizes an embedded electrode in the microfluidic to perform measurement of electrical impedance of the presence of cells at the sensing area. Nonetheless, this method requires an expensive and complicated electrode fabrication process. Furthermore, reuse of the fabricated electrode also requires an intensive and tedious cleaning process. Due to that, we present a microfluidic device with integrated microneedles. The two microneedles are placed at the half height of the microchannel for cell detection and electrical measurement. A commercially-available Tungsten needle was utilized for the microneedles. The microneedles are easily removed from the disposable PDMS (Polydimethylsiloxane microchannel and can be reused with a simple cleaning process, such as washing by ultrasonic cleaning. Although this device was low cost, it preserves the core functionality of the sensor, which is capable of detecting passing cells at the sensing area. Therefore, this device is suitable for low-cost medical and food safety screening and testing process in developing countries.

  2. Numerical evaluation of path-integral solutions to Fokker-Planck equations. II. Restricted stochastic processes

    International Nuclear Information System (INIS)

    Wehner, M.F.

    1983-01-01

    A path-integral solution is derived for processes described by nonlinear Fokker-Plank equations together with externally imposed boundary conditions. This path-integral solution is written in the form of a path sum for small time steps and contains, in addition to the conventional volume integral, a surface integral which incorporates the boundary conditions. A previously developed numerical method, based on a histogram representation of the probability distribution, is extended to a trapezoidal representation. This improved numerical approach is combined with the present path-integral formalism for restricted processes and is show t give accurate results. 35 refs., 5 figs

  3. Finite Element Analysis of Single Cell Stiffness Measurements Using PZT-Integrated Buckling Nanoneedles

    Directory of Open Access Journals (Sweden)

    Maryam Alsadat Rad

    2016-12-01

    Full Text Available This paper proposes a new technique for real-time single cell stiffness measurement using lead zirconate titanate (PZT-integrated buckling nanoneedles. The PZT and the buckling part of the nanoneedle have been modelled and validated using the ABAQUS software. The two parts are integrated together to function as a single unit. After calibration, the stiffness, Young’s modulus, Poisson’s ratio and sensitivity of the PZT-integrated buckling nanoneedle have been determined to be 0.7100 N·m−1, 123.4700 GPa, 0.3000 and 0.0693 V·m·N−1, respectively. Three Saccharomyces cerevisiae cells have been modelled and validated based on compression tests. The average global stiffness and Young’s modulus of the cells are determined to be 10.8867 ± 0.0094 N·m−1 and 110.7033 ± 0.0081 MPa, respectively. The nanoneedle and the cell have been assembled to measure the local stiffness of the single Saccharomyces cerevisiae cells The local stiffness, Young’s modulus and PZT output voltage of the three different size Saccharomyces cerevisiae have been determined at different environmental conditions. We investigated that, at low temperature the stiffness value is low to adapt to the change in the environmental condition. As a result, Saccharomyces cerevisiae becomes vulnerable to viral and bacterial attacks. Therefore, the proposed technique will serve as a quick and accurate process to diagnose diseases at early stage in a cell for effective treatment.

  4. INTEGRATION OF COST MODELS AND PROCESS SIMULATION TOOLS FOR OPTIMUM COMPOSITE MANUFACTURING PROCESS

    Energy Technology Data Exchange (ETDEWEB)

    Pack, Seongchan [General Motors; Wilson, Daniel [General Motors; Aitharaju, Venkat [General Motors; Kia, Hamid [General Motors; Yu, Hang [ESI, Group.; Doroudian, Mark [ESI Group

    2017-09-05

    Manufacturing cost of resin transfer molded composite parts is significantly influenced by the cycle time, which is strongly related to the time for both filling and curing of the resin in the mold. The time for filling can be optimized by various injection strategies, and by suitably reducing the length of the resin flow distance during the injection. The curing time can be reduced by the usage of faster curing resins, but it requires a high pressure injection equipment, which is capital intensive. Predictive manufacturing simulation tools that are being developed recently for composite materials are able to provide various scenarios of processing conditions virtually well in advance of manufacturing the parts. In the present study, we integrate the cost models with process simulation tools to study the influence of various parameters such as injection strategies, injection pressure, compression control to minimize high pressure injection, resin curing rate, and demold time on the manufacturing cost as affected by the annual part volume. A representative automotive component was selected for the study and the results are presented in this paper

  5. Integrating Effectiveness, Transparency and Fairness into a Value Elicitation Process

    International Nuclear Information System (INIS)

    Fortier, Michael; Sheng, Grant

    2001-01-01

    As part of the evaluation of Canada's proposed nuclear fuel waste disposal concept, the Federal Environmental Assessment and Review Panel (FEARP) undertook an extensive, nation-wide public hearing process. The hearing process itself was contentious and has been criticized on numerous grounds. It is our contention that the fundamental weakness of the FEARP process was that it was designed as an information-based forum, as opposed to a value-based forum.' Our observations and analyses of these hearings indicate that the FEARP envisioned a different purpose and a different outcome of this process than the public in general. As a result, public acceptability for the Concept or even the assessment process itself was not garnered due to a failure in the process to identify, address and incorporate values. To address this, we proposed a seven-step value elicitation process specifically designed to assess public acceptability of the disposal concept. An unfortunate consequence of the flawed public consultation process employed by the FEARP is that it is unclear exactly what it is the public finds unacceptable. Both from discussions and observations, it is difficult to ascertain whether the unacceptability lies with the Concept itself and/or the process by which the Concept was to be assessed. As a result, there is uncertainty as to what questions should be asked and how should the 'unacceptability' be addressed. In other words, does Canada need a new concept? Does Canada need to develop a mechanism for assessing the public acceptability of the Concept? Or both? The inability of the current process to answer such fundamental questions demonstrates the importance of developing an effective public acceptability and consultation process. We submit that, to create an acceptable Public Participation mechanism, it is necessary to found the construction of such a mechanism on the principles of effectiveness, transparency and fairness. Moreover, we believe that the larger decision

  6. Integrating Effectiveness, Transparency and Fairness into a Value Elicitation Process

    Energy Technology Data Exchange (ETDEWEB)

    Fortier, Michael; Sheng, Grant [York Univ., Toronto, ON (Canada). Faculty of Environmental Studies; Collins, Alison [York Centre for Applied Sustainability, Toronto, ON (Canada)

    2001-07-01

    As part of the evaluation of Canada's proposed nuclear fuel waste disposal concept, the Federal Environmental Assessment and Review Panel (FEARP) undertook an extensive, nation-wide public hearing process. The hearing process itself was contentious and has been criticized on numerous grounds. It is our contention that the fundamental weakness of the FEARP process was that it was designed as an information-based forum, as opposed to a value-based forum.' Our observations and analyses of these hearings indicate that the FEARP envisioned a different purpose and a different outcome of this process than the public in general. As a result, public acceptability for the Concept or even the assessment process itself was not garnered due to a failure in the process to identify, address and incorporate values. To address this, we proposed a seven-step value elicitation process specifically designed to assess public acceptability of the disposal concept. An unfortunate consequence of the flawed public consultation process employed by the FEARP is that it is unclear exactly what it is the public finds unacceptable. Both from discussions and observations, it is difficult to ascertain whether the unacceptability lies with the Concept itself and/or the process by which the Concept was to be assessed. As a result, there is uncertainty as to what questions should be asked and how should the 'unacceptability' be addressed. In other words, does Canada need a new concept? Does Canada need to develop a mechanism for assessing the public acceptability of the Concept? Or both? The inability of the current process to answer such fundamental questions demonstrates the importance of developing an effective public acceptability and consultation process. We submit that, to create an acceptable Public Participation mechanism, it is necessary to found the construction of such a mechanism on the principles of effectiveness, transparency and fairness. Moreover, we believe that

  7. Current efficiency in the chlorate cell process

    Directory of Open Access Journals (Sweden)

    Spasojević Miroslav D.

    2014-01-01

    Full Text Available A mathematical model has been set up for current efficiency in a chlorate cell acting as an ideal electrochemical tubular reactor with a linear increase in hypochlorite concentration from the entrance to the exit. Good agreement was found between the results on current efficiency experimentally obtained under simulated industrial chlorate production conditions and the theoretical values provided by the mathematical model. [Projekat Ministarstva nauke Republike Srbije, br. 172057 i br. 172062

  8. Supporting BPMN choreography with system integration artefacts for enterprise process collaboration

    NARCIS (Netherlands)

    Nie, H.; Lu, X.; Duan, H.

    2014-01-01

    Business Process Model and Notation (BPMN) choreography modelling depicts externally visible message exchanges between collaborating processes of enterprise information systems. Implementation of choreography relies on designing system integration solutions to realise message exchanges between

  9. Knowledge Integrated Business Process Management for Third Party Logistics Companies

    OpenAIRE

    Zhang, Hongyan

    2013-01-01

    The growing importance of logistics as well as the increasing dynamic complexity of markets, technologies, and customer needs has brought great challenges to logistics. In order to focus on their core competency in such a competitive environment, more and more companies have outsourced a part or the entirety of the logistics process to third party logistics (3PL) service providers. 3PL has played a crucial role in managing logistics processes within supply chain management. Logistics processe...

  10. Integrative Dynamic Reconfiguration in a Parallel Stream Processing Engine

    DEFF Research Database (Denmark)

    Madsen, Kasper Grud Skat; Zhou, Yongluan; Cao, Jianneng

    2017-01-01

    Load balancing, operator instance collocations and horizontal scaling are critical issues in Parallel Stream Processing Engines to achieve low data processing latency, optimized cluster utilization and minimized communication cost respectively. In previous work, these issues are typically tackled...... solution called ALBIC, which support general jobs. We implement the proposed techniques on top of Apache Storm, an open-source Parallel Stream Processing Engine. The extensive experimental results over both synthetic and real datasets show that our techniques clearly outperform existing approaches....

  11. "COUPLED PROCESSES" AS DYNAMIC CAPABILITIES IN SYSTEMS INTEGRATION

    OpenAIRE

    Chagas Jr, Milton de Freitas; Leite, Dinah Eluze Sales; Jesus, Gabriel Torres de

    2017-01-01

    ABSTRACT The dynamics of innovation in complex systems industries is becoming an independent research stream. Apart from conventional uncertainties related to commerce and technology, complex-system industries must cope with systemic uncertainty. This paper's objective is to analyze evolving technological paths from one product generation to the next through two case studies in the Brazilian aerospace industry, considering systems integration as an empirical instantiation of dynamic capabilit...

  12. Hypoxia-elicited impairment of cell wall integrity, glycosylation precursor synthesis, and growth in scaled-up high-cell density fed-batch cultures of Saccharomyces cerevisiae.

    Science.gov (United States)

    Aon, Juan C; Sun, Jianxin; Leighton, Julie M; Appelbaum, Edward R

    2016-08-15

    In this study we examine the integrity of the cell wall during scale up of a yeast fermentation process from laboratory scale (10 L) to industrial scale (10,000 L). In a previous study we observed a clear difference in the volume fraction occupied by yeast cells as revealed by wet cell weight (WCW) measurements between these scales. That study also included metabolite analysis which suggested hypoxia during scale up. Here we hypothesize that hypoxia weakens the yeast cell wall during the scale up, leading to changes in cell permeability, and/or cell mechanical resistance, which in turn may lead to the observed difference in WCW. We tested the cell wall integrity by probing the cell wall sensitivity to Zymolyase. Also exometabolomics data showed changes in supply of precursors for the glycosylation pathway. The results show a more sensitive cell wall later in the production process at industrial scale, while the sensitivity at early time points was similar at both scales. We also report exometabolomics data, in particular a link with the protein glycosylation pathway. Significantly lower levels of Man6P and progressively higher GDP-mannose indicated partially impaired incorporation of this sugar nucleotide during co- or post-translational protein glycosylation pathways at the 10,000 L compared to the 10 L scale. This impairment in glycosylation would be expected to affect cell wall integrity. Although cell viability from samples obtained at both scales were similar, cells harvested from 10 L bioreactors were able to re-initiate growth faster in fresh shake flask media than those harvested from the industrial scale. The results obtained help explain the WCW differences observed at both scales by hypoxia-triggered weakening of the yeast cell wall during the scale up.

  13. Simple processing of high efficiency silicon solar cells

    International Nuclear Information System (INIS)

    Hamammu, I.M.; Ibrahim, K.

    2006-01-01

    Cost effective photovoltaic devices have been an area research since the development of the first solar cells, as cost is the major factor in their usage. Silicon solar cells have the biggest share in the photovoltaic market, though silicon os not the optimal material for solar cells. This work introduces a simplified approach for high efficiency silicon solar cell processing, by minimizing the processing steps and thereby reducing cost. The suggested procedure might also allow for the usage of lower quality materials compared to the one used today. The main features of the present work fall into: simplifying the diffusion process, edge shunt isolation and using acidic texturing instead of the standard alkaline processing. Solar cells of 17% efficiency have been produced using this procedure. Investigations on the possibility of improving the efficiency and using less quality material are still underway

  14. Enhancing Student Learning of Enterprise Integration and Business Process Orientation through an ERP Business Simulation Game

    Science.gov (United States)

    Seethamraju, Ravi

    2011-01-01

    The sophistication of the integrated world of work and increased recognition of business processes as critical corporate assets require graduates to develop "process orientation" and an "integrated view" of business. Responding to these dynamic changes in business organizations, business schools are also continuing to modify…

  15. Career-Oriented Performance Tasks in Chemistry: Effects on Students Integrated Science Process Skills

    OpenAIRE

    Allen A. Espinosa; Sheryl Lyn C. Monterola; Amelia E. Punzalan

    2013-01-01

    The study was conducted to assess the effectiveness of Career-Oriented Performance Task (COPT) approach against the traditional teaching approach (TTA) in enhancing students’ integrated science process skills. Specifically, it sought to find out if students exposed to COPT have higher integrated science process skills than those students exposed to the traditional teaching approach (TTA). Career-Oriented Performance Task (COPT) approach aims to integrate career-oriented examples and inquiry-b...

  16. Integrated process for the removal of emulsified oils from effluents in the steel industry

    Energy Technology Data Exchange (ETDEWEB)

    Benito, J.M.; Rios, G.; Gutierrez, B.; Pazos, C.; Coca, J.

    1999-11-01

    Emulsified oils contained in aqueous effluents from cold-rolling mills of the steel industry can be effectively removed via an integrated process consisting of a coagulation/flocculation stage followed by ultrafiltration of the resulting aqueous phase. The effects of CaCl{sub 2}, NaOH, and lime on the stability of different industrial effluents were studied in the coagulation experiments. The flocculants tested were inorganic prehydrolyzed aluminum salts and quaternary polyamines. Ultrafiltration of the aqueous phase from the coagulation/flocculation stage was carried out in a stirred cell using Amicon PM30 and XM300 organic membranes. Permeate fluxes were measured for industrial effluents to which the indicated coagulants and flocculants had been added. Oil concentrations in the permeate were 75% lower than the limits established by all European Union countries. Complete regeneration of the membrane was accomplished with an aqueous solution of a commercial detergent.

  17. Integrating system safety into the basic systems engineering process

    Science.gov (United States)

    Griswold, J. W.

    1971-01-01

    The basic elements of a systems engineering process are given along with a detailed description of what the safety system requires from the systems engineering process. Also discussed is the safety that the system provides to other subfunctions of systems engineering.

  18. Business process compliance management : an integrated proactive approach

    NARCIS (Netherlands)

    Elgammal, A.; Sebahi, S.; Turetken, O.; Hacid, M.-S.; Papazoglou, M.; van den Heuvel, W.; Soliman, K.S.

    2014-01-01

    Today’s enterprises demand a high degree of compliance of business processes to meet regulations, such as Sarbanes-Oxley and Basel I-III. To ensure continuous guaranteed compliance, compliance management should be considered during all phases of the business process lifecycle; from the analysis and

  19. Integrating ICT applications for farm business collaboration processes using FIspace

    NARCIS (Netherlands)

    Kruize, J.W.; Wolfert, J.; Goense, D.; Scholten, H.; Beulens, A.J.M.; Veenstra, T.

    2014-01-01

    Agri-Food Supply Chain Networks are required to increase production and to be transparent while reducing environmental impact. This challenges farm enterprises to innovate their production processes. These processes need to be supported by advanced ICT components that are developed by multiple

  20. Manufacturing Squares: An Integrative Statistical Process Control Exercise

    Science.gov (United States)

    Coy, Steven P.

    2016-01-01

    In the exercise, students in a junior-level operations management class are asked to manufacture a simple product. Given product specifications, they must design a production process, create roles and design jobs for each team member, and develop a statistical process control plan that efficiently and effectively controls quality during…

  1. IDEAS, for integral logistics in centralized wood processing

    NARCIS (Netherlands)

    Reinders, M.P.

    1989-01-01

    A decision support system (DSS) is developed to improve the quality of decision making in wood processing companies. Wood processing companies are businesses that import (buy, harvest) raw materials, stems and logs, and export (deliver) products, assortments and boards, after a multi-step

  2. Purifier-integrated methanol reformer for fuel cell vehicles

    Science.gov (United States)

    Han, Jaesung; Kim, Il-soo; Choi, Keun-Sup

    We developed a compact, 3-kW, purifier-integrated modular reformer which becomes the building block of full-scale 30-kW or 50-kW methanol fuel processors for fuel cell vehicles. Our proprietary technologies regarding hydrogen purification by composite metal membrane and catalytic combustion by washcoated wire-mesh catalyst were combined with the conventional methanol steam-reforming technology, resulting in higher conversion, excellent quality of product hydrogen, and better thermal efficiency than any other systems using preferential oxidation. In this system, steam reforming, hydrogen purification, and catalytic combustion all take place in a single reactor so that the whole system is compact and easy to operate. Hydrogen from the module is ultrahigh pure (99.9999% or better), hence there is no power degradation of PEMFC stack due to contamination by CO. Also, since only pure hydrogen is supplied to the anode of the PEMFC stack, 100% hydrogen utilization is possible in the stack. The module produces 2.3 Nm 3/h of hydrogen, which is equivalent to 3 kW when PEMFC has 43% efficiency. Thermal efficiency (HHV of product H 2/HHV of MeOH in) of the module is 89% and the power density of the module is 0.77 kW/l. This work was conducted in cooperation with Hyundai Motor Company in the form of a Korean national project. Currently the module is under test with an actual fuel cell stack in order to verify its performance. Sooner or later a full-scale 30-kW system will be constructed by connecting these modules in series and parallel and will serve as the fuel processor for the Korean first fuel cell hybrid vehicle.

  3. Processes for chalcopyrite-based solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Lux-Steiner, M.C.; Ennaoui, A.; Fischer, C.-H.; Jaeger-Waldau, A.; Klaer, J.; Klenk, R.; Koenenkamp, R.; Matthes, T.; Scheer, R.; Siebentritt, S.; Weidinger, A. [Hahn-Meitner-Institut Berlin GmbH (Germany)

    2000-02-21

    This contribution deals with the investigations of chalcopyrite solar cells. Main attention is paid to absorber materials with band gaps larger than 1.5 eV. Besides the different efforts to modify and optimise stoichiometric CuInS{sub 2} films, novel deposition technologies for CuGaSe{sub 2} films and buffer layers as well as alternative buffer layers were studied and compared. With ZnSe as alternative buffer layer on Cu(InGa)(S,Se){sub 2} absorbers developed by SSI Camarillo and Siemens Solar, Munich, total area efficiencies up to 13.7% and active area efficiencies up to 15.7% could be reached, respectively. For CuInS{sub 2} two important results were achieved. The efficiency of Cu-poor CuInS{sub 2} cells could be increased to 8.3%. Standard Cu-rich prepared devices led to a new record efficiency of 12.5%. (orig.)

  4. Effect of different machining processes on the tool surface integrity and fatigue life

    Energy Technology Data Exchange (ETDEWEB)

    Cao, Chuan Liang [College of Mechanical and Electrical Engineering, Nanchang University, Nanchang (China); Zhang, Xianglin [School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan (China)

    2016-08-15

    Ultra-precision grinding, wire-cut electro discharge machining and lapping are often used to machine the tools in fine blanking industry. And the surface integrity from these machining processes causes great concerns in the research field. To study the effect of processing surface integrity on the fine blanking tool life, the surface integrity of different tool materials under different processing conditions and its influence on fatigue life were thoroughly analyzed in the present study. The result shows that the surface integrity of different materials was quite different on the same processing condition. For the same tool material, the surface integrity on varying processing conditions was quite different too and deeply influenced the fatigue life.

  5. Integrating artificial and human intelligence into tablet production process.

    Science.gov (United States)

    Gams, Matjaž; Horvat, Matej; Ožek, Matej; Luštrek, Mitja; Gradišek, Anton

    2014-12-01

    We developed a new machine learning-based method in order to facilitate the manufacturing processes of pharmaceutical products, such as tablets, in accordance with the Process Analytical Technology (PAT) and Quality by Design (QbD) initiatives. Our approach combines the data, available from prior production runs, with machine learning algorithms that are assisted by a human operator with expert knowledge of the production process. The process parameters encompass those that relate to the attributes of the precursor raw materials and those that relate to the manufacturing process itself. During manufacturing, our method allows production operator to inspect the impacts of various settings of process parameters within their proven acceptable range with the purpose of choosing the most promising values in advance of the actual batch manufacture. The interaction between the human operator and the artificial intelligence system provides improved performance and quality. We successfully implemented the method on data provided by a pharmaceutical company for a particular product, a tablet, under development. We tested the accuracy of the method in comparison with some other machine learning approaches. The method is especially suitable for analyzing manufacturing processes characterized by a limited amount of data.

  6. Cell-assembly coding in several memory processes.

    Science.gov (United States)

    Sakurai, Y

    1998-01-01

    The present paper discusses why the cell assembly, i.e., an ensemble population of neurons with flexible functional connections, is a tenable view of the basic code for information processes in the brain. The main properties indicating the reality of cell-assembly coding are neurons overlaps among different assemblies and connection dynamics within and among the assemblies. The former can be detected as multiple functions of individual neurons in processing different kinds of information. Individual neurons appear to be involved in multiple information processes. The latter can be detected as changes of functional synaptic connections in processing different kinds of information. Correlations of activity among some of the recorded neurons appear to change in multiple information processes. Recent experiments have compared several different memory processes (tasks) and detected these two main properties, indicating cell-assembly coding of memory in the working brain. The first experiment compared different types of processing of identical stimuli, i.e., working memory and reference memory of auditory stimuli. The second experiment compared identical processes of different types of stimuli, i.e., discriminations of simple auditory, simple visual, and configural auditory-visual stimuli. The third experiment compared identical processes of different types of stimuli with or without temporal processing of stimuli, i.e., discriminations of elemental auditory, configural auditory-visual, and sequential auditory-visual stimuli. Some possible features of the cell-assembly coding, especially "dual coding" by individual neurons and cell assemblies, are discussed for future experimental approaches. Copyright 1998 Academic Press.

  7. Analysis of the Growth Process of Neural Cells in Culture Environment Using Image Processing Techniques

    Science.gov (United States)

    Mirsafianf, Atefeh S.; Isfahani, Shirin N.; Kasaei, Shohreh; Mobasheri, Hamid

    Here we present an approach for processing neural cells images to analyze their growth process in culture environment. We have applied several image processing techniques for: 1- Environmental noise reduction, 2- Neural cells segmentation, 3- Neural cells classification based on their dendrites' growth conditions, and 4- neurons' features Extraction and measurement (e.g., like cell body area, number of dendrites, axon's length, and so on). Due to the large amount of noise in the images, we have used feed forward artificial neural networks to detect edges more precisely.

  8. Roll-to-roll processed polymer tandem solar cells partially processed from water

    DEFF Research Database (Denmark)

    Larsen-Olsen, Thue Trofod; Andersen, Thomas Rieks; Andreasen, Birgitta

    2012-01-01

    Large area polymer tandem solar cells completely processed using roll-to-roll (R2R) coating and printing techniques are demonstrated. A stable tandem structure was achieved by the use of orthogonal ink solvents for the coating of all layers, including both active layers. Processing solvents...... included water, alcohols and chlorobenzene. Open-circuit voltages close to the expected sum of sub cell voltages were achieved, while the overall efficiency of the tandem cells was found to be limited by the low yielding back cell, which was processed from water based ink. Many of the challenges associated...

  9. Parallel and convergent processing in grid cell, head-direction cell, boundary cell, and place cell networks.

    Science.gov (United States)

    Brandon, Mark P; Koenig, Julie; Leutgeb, Stefan

    2014-03-01

    The brain is able to construct internal representations that correspond to external spatial coordinates. Such brain maps of the external spatial topography may support a number of cognitive functions, including navigation and memory. The neuronal building block of brain maps are place cells, which are found throughout the hippocampus of rodents and, in a lower proportion, primates. Place cells typically fire in one or few restricted areas of space, and each area where a cell fires can range, along the dorsoventral axis of the hippocampus, from 30 cm to at least several meters. The sensory processing streams that give rise to hippocampal place cells are not fully understood, but substantial progress has been made in characterizing the entorhinal cortex, which is the gateway between neocortical areas and the hippocampus. Entorhinal neurons have diverse spatial firing characteristics, and the different entorhinal cell types converge in the hippocampus to give rise to a single, spatially modulated cell type-the place cell. We therefore suggest that parallel information processing in different classes of cells-as is typically observed at lower levels of sensory processing-continues up into higher level association cortices, including those that provide the inputs to hippocampus. WIREs Cogn Sci 2014, 5:207-219. doi: 10.1002/wcs.1272 Conflict of interest: The authors have declared no conflicts of interest for this article. For further resources related to this article, please visit the WIREs website. © 2013 John Wiley & Sons, Ltd.

  10. Integrated Modeling of Process, Structures and Performance in Cast Parts

    DEFF Research Database (Denmark)

    Kotas, Petr

    This thesis deals with numerical simulations of gravity sand casting processes for the production of large steel parts. The entire manufacturing process is numerically modeled and evaluated, taking into consideration mould filling, solidification, solid state cooling and the subsequent stress build...... and to defects occurrence. In other words, it is desired to eliminate all of the potential casting defects and at the same time to maximize the casting yield. The numerical optimization algorithm then takes these objectives and searches for a set of the investigated process, design or material parameters e.......g. chill design, riser design, gating system design, etc., which would satisfy these objectives the most. The first step in the numerical casting process simulation is to analyze mould filling where the emphasis is put on the gating system design. There are still a lot of foundry specialists who ignore...

  11. Dosimetry as an integral part of radiation processing

    International Nuclear Information System (INIS)

    Zagorski, Z.P.

    1999-01-01

    Different connections between high-dose dosimetry and radiation processing are discussed. Radiation processing cannot be performed without proper dosimetry. Accurate high dose and high dose rate dosimetry exhibits several aspects: first of all it is the preservation of the quality of the product, then fulfillment of legal aspects and last but not the least the safety of processing. Further, seldom discussed topics are as follow: dosimetric problems occurring with double-side EB irradiations, discussed in connection with the deposition of electric charge during electron beam irradiation. Although dosimetry for basic research and for medical purposes are treated here only shortly, some conclusions reached from these fields are considered in dosimetry for radiation processing. High-dose dosimetry of radiation has become a separate field, with many papers published every year, but applied dosimetric projects are usually initiated by a necessity of particular application. (author)

  12. Synthesis and Design of Integrated Process and Water Networks

    DEFF Research Database (Denmark)

    Handani, Zainatul B.; Quaglia, Alberto; Gani, Rafiqul

    2015-01-01

    This work presents the development of a systematic framework for a simultaneous synthesis and design of process and water networks using the superstructure-based optimization approach. In this framework, a new superstructure combining both networks is developed by attempting to consider all...... possible options with respect to the topology of the process and water networks, leading to Mixed Integer Non Linear Programming (MINLP) problem. A solution strategy to solve the multi-network problem accounts explicitly the interactions between the networks by selecting suitable technologies in order...... to transform raw materials into products and produce clean water to be reused in the process at the early stage of design. Since the connection between the process network and the wastewater treatment network is not a straight forward connection, a new converter interval is introduced in order to convert...

  13. Integration of distributed computing into the drug discovery process.

    Science.gov (United States)

    von Korff, Modest; Rufener, Christian; Stritt, Manuel; Freyss, Joel; Bär, Roman; Sander, Thomas

    2011-02-01

    Grid computing offers an opportunity to gain massive computing power at low costs. We give a short introduction into the drug discovery process and exemplify the use of grid computing for image processing, docking and 3D pharmacophore descriptor calculations. The principle of a grid and its architecture are briefly explained. More emphasis is laid on the issues related to a company-wide grid installation and embedding the grid into the research process. The future of grid computing in drug discovery is discussed in the expert opinion section. Most needed, besides reliable algorithms to predict compound properties, is embedding the grid seamlessly into the discovery process. User friendly access to powerful algorithms without any restrictions, that is, by a limited number of licenses, has to be the goal of grid computing in drug discovery.

  14. FUNDAMENTAL TUNNELING PROCESSES IN MOSa SOLAR CELLS

    OpenAIRE

    Balberg , I.; Hanak , J.; Weakliem , H.; Gal , E.

    1981-01-01

    In previous studies of tunneling through a MOSa tunnel junction, where Sa was a-Si : H, it was shown that their characteristics resemble those of MOSc devices where Sc was crystalline silicon. In the present work we would like to report a demonstration of fundamental tunneling processes in such tunnel junctions. In particular, the transition from semiconductor controlled regime to tunneling controlled regime can be clearly distinguished. The present results represent one of the rare cases whe...

  15. Heat Integration and Renewable Energy in Meat Processing Plants

    OpenAIRE

    Colley, Tracey Anne

    2016-01-01

    This thesis aims to optimise energy efficiency at meat processing plants and minimise their carbon footprint, as a way of reducing operating costs and minimising the potential negative impacts of a carbon price on the red meat industry. In the context of the export meat industry, there is continual competition with the live export trade. Therefore, there is a risk that a carbon price could increase the live export trade over domestic processing of meat, thereby exporti...

  16. Manufacturing of tailored tubes with a process integrated heat treatment

    Science.gov (United States)

    Hordych, Illia; Boiarkin, Viacheslav; Rodman, Dmytro; Nürnberger, Florian

    2017-10-01

    The usage of work-pieces with tailored properties allows for reducing costs and materials. One example are tailored tubes that can be used as end parts e.g. in the automotive industry or in domestic applications as well as semi-finished products for subsequent controlled deformation processes. An innovative technology to manufacture tubes is roll forming with a subsequent inductive heating and adapted quenching to obtain tailored properties in the longitudinal direction. This processing offers a great potential for the production of tubes with a wide range of properties, although this novel approach still requires a suited process design. Based on experimental data, a process simulation is being developed. The simulation shall be suitable for a virtual design of the tubes and allows for gaining a deeper understanding of the required processing. The model proposed shall predict microstructural and mechanical tube properties by considering process parameters, different geometries, batch-related influences etc. A validation is carried out using experimental data of tubes manufactured from various steel grades.

  17. Applications of Laser Precisely Processing Technology in Solar Cells

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    According to the design method of laser resonator cavity, we optimized the primary parameters of resonator and utilized LD arrays symmetrically pumping manner to implementing output of the high-brightness laser in our laser cutter, then which was applied to precisely cutting the conductive film of CuInSe2 solar cells, the buried contact silicon solar cells' electrode groove, and perforating in wafer which is used to the emitter wrap through silicon solar cells. Laser processing precision was less than 40μm, the results have met solar cell's fabrication technology, and made finally the buried cells' conversion efficiency be improved from 18% to 21% .

  18. The integration process of immigrants: limits and new contributions for a more comprehensive study

    Directory of Open Access Journals (Sweden)

    Yolanda González- Rábago

    2014-02-01

    Full Text Available The integration process of immigrants is a complex issue of conceptualization and extensive discussion both in the field of public policy and from the academia. The alleged European consensus about integration has only been in the comfortable speech of bidirectionality and the study of the integration process in host societies has been raised ever from quantifier and objectivist parameters that are not able to grasp the diversity of thereof. Furthermore, the study of integration has overlooked the importance of the society of origin and the link that immigrants remain with them, focusing only on the host society as a place of integration. In this paper I propose the extension of the look on the integration by incorporating the perspective of origin and the subjectivity of the immigrants as an actor with the capacity to question, decide and change the patterns and contexts in which integration occurs.

  19. Machine Learning Based Single-Frame Super-Resolution Processing for Lensless Blood Cell Counting

    Directory of Open Access Journals (Sweden)

    Xiwei Huang

    2016-11-01

    Full Text Available A lensless blood cell counting system integrating microfluidic channel and a complementary metal oxide semiconductor (CMOS image sensor is a promising technique to miniaturize the conventional optical lens based imaging system for point-of-care testing (POCT. However, such a system has limited resolution, making it imperative to improve resolution from the system-level using super-resolution (SR processing. Yet, how to improve resolution towards better cell detection and recognition with low cost of processing resources and without degrading system throughput is still a challenge. In this article, two machine learning based single-frame SR processing types are proposed and compared for lensless blood cell counting, namely the Extreme Learning Machine based SR (ELMSR and Convolutional Neural Network based SR (CNNSR. Moreover, lensless blood cell counting prototypes using commercial CMOS image sensors and custom designed backside-illuminated CMOS image sensors are demonstrated with ELMSR and CNNSR. When one captured low-resolution lensless cell image is input, an improved high-resolution cell image will be output. The experimental results show that the cell resolution is improved by 4×, and CNNSR has 9.5% improvement over the ELMSR on resolution enhancing performance. The cell counting results also match well with a commercial flow cytometer. Such ELMSR and CNNSR therefore have the potential for efficient resolution improvement in lensless blood cell counting systems towards POCT applications.

  20. New design for photonic temporal integration with combined high processing speed and long operation time window.

    Science.gov (United States)

    Asghari, Mohammad H; Park, Yongwoo; Azaña, José

    2011-01-17

    We propose and experimentally prove a novel design for implementing photonic temporal integrators simultaneously offering a high processing bandwidth and a long operation time window, namely a large time-bandwidth product. The proposed scheme is based on concatenating in series a time-limited ultrafast photonic temporal integrator, e.g. implemented using a fiber Bragg grating (FBG), with a discrete-time (bandwidth limited) optical integrator, e.g. implemented using an optical resonant cavity. This design combines the advantages of these two previously demonstrated photonic integrator solutions, providing a processing speed as high as that of the time-limited ultrafast integrator and an operation time window fixed by the discrete-time integrator. Proof-of-concept experiments are reported using a uniform fiber Bragg grating (as the original time-limited integrator) connected in series with a bulk-optics coherent interferometers' system (as a passive 4-points discrete-time photonic temporal integrator). Using this setup, we demonstrate accurate temporal integration of complex-field optical signals with time-features as fast as ~6 ps, only limited by the processing bandwidth of the FBG integrator, over time durations as long as ~200 ps, which represents a 4-fold improvement over the operation time window (~50 ps) of the original FBG integrator.

  1. Sequenced Integration and the Identification of a Problem-Solving Approach through a Learning Process

    Science.gov (United States)

    Cormas, Peter C.

    2016-01-01

    Preservice teachers (N = 27) in two sections of a sequenced, methodological and process integrated mathematics/science course solved a levers problem with three similar learning processes and a problem-solving approach, and identified a problem-solving approach through one different learning process. Similar learning processes used included:…

  2. An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development

    Science.gov (United States)

    Benitez, Cecil M.; Qu, Kun; Sugiyama, Takuya; Pauerstein, Philip T.; Liu, Yinghua; Tsai, Jennifer; Gu, Xueying; Ghodasara, Amar; Arda, H. Efsun; Zhang, Jiajing; Dekker, Joseph D.; Tucker, Haley O.; Chang, Howard Y.; Kim, Seung K.

    2014-01-01

    The regulatory logic underlying global transcriptional programs controlling development of visceral organs like the pancreas remains undiscovered. Here, we profiled gene expression in 12 purified populations of fetal and adult pancreatic epithelial cells representing crucial progenitor cell subsets, and their endocrine or exocrine progeny. Using probabilistic models to decode the general programs organizing gene expression, we identified co-expressed gene sets in cell subsets that revealed patterns and processes governing progenitor cell development, lineage specification, and endocrine cell maturation. Purification of Neurog3 mutant cells and module network analysis linked established regulators such as Neurog3 to unrecognized gene targets and roles in pancreas development. Iterative module network analysis nominated and prioritized transcriptional regulators, including diabetes risk genes. Functional validation of a subset of candidate regulators with corresponding mutant mice revealed that the transcription factors Etv1, Prdm16, Runx1t1 and Bcl11a are essential for pancreas development. Our integrated approach provides a unique framework for identifying regulatory genes and functional gene sets underlying pancreas development and associated diseases such as diabetes mellitus. PMID:25330008

  3. An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development.

    Directory of Open Access Journals (Sweden)

    Cecil M Benitez

    2014-10-01

    Full Text Available The regulatory logic underlying global transcriptional programs controlling development of visceral organs like the pancreas remains undiscovered. Here, we profiled gene expression in 12 purified populations of fetal and adult pancreatic epithelial cells representing crucial progenitor cell subsets, and their endocrine or exocrine progeny. Using probabilistic models to decode the general programs organizing gene expression, we identified co-expressed gene sets in cell subsets that revealed patterns and processes governing progenitor cell development, lineage specification, and endocrine cell maturation. Purification of Neurog3 mutant cells and module network analysis linked established regulators such as Neurog3 to unrecognized gene targets and roles in pancreas development. Iterative module network analysis nominated and prioritized transcriptional regulators, including diabetes risk genes. Functional validation of a subset of candidate regulators with corresponding mutant mice revealed that the transcription factors Etv1, Prdm16, Runx1t1 and Bcl11a are essential for pancreas development. Our integrated approach provides a unique framework for identifying regulatory genes and functional gene sets underlying pancreas development and associated diseases such as diabetes mellitus.

  4. An integrative approach to knowledge transfer and integration: Spanning boundaries through objects, people and processes

    NARCIS (Netherlands)

    Duijn, M.; Rijnveld, M.

    2008-01-01

    Knowledge transfer and integration is the main challenge in many knowledge management projects. This challenge follows from the observation that it is difficult to determine how and what knowledge may transfer from one person to another, from one team to another and from one network or organization

  5. Silicon Solar Cell Process Development, Fabrication and Analysis, Phase 1

    Science.gov (United States)

    Yoo, H. I.; Iles, P. A.; Tanner, D. P.

    1979-01-01

    Solar cells from RTR ribbons, EFG (RF and RH) ribbons, dendritic webs, Silso wafers, cast silicon by HEM, silicon on ceramic, and continuous Czochralski ingots were fabricated using a standard process typical of those used currently in the silicon solar cell industry. Back surface field (BSF) processing and other process modifications were included to give preliminary indications of possible improved performance. The parameters measured included open circuit voltage, short circuit current, curve fill factor, and conversion efficiency (all taken under AM0 illumination). Also measured for typical cells were spectral response, dark I-V characteristics, minority carrier diffusion length, and photoresponse by fine light spot scanning. the results were compared to the properties of cells made from conventional single crystalline Czochralski silicon with an emphasis on statistical evaluation. Limited efforts were made to identify growth defects which will influence solar cell performance.

  6. A solution process for inverted tandem solar cells

    DEFF Research Database (Denmark)

    Larsen-Olsen, Thue Trofod; Bundgaard, Eva; Sylvester-Hvid, Kristian O.

    2011-01-01

    Tandem solar cells with normal and inverted device geometries were prepared by a solution process. Both device types were based on the use of zinc(II)oxide as the electron transporting layer (ETL). The hole transporting layer (HTL) was either PEDOT:PSS for normal geometry tandem solar cells...... or vanadium(V)oxide in the case of inverted tandem cells. It was found that the inverted tandem solar cells performed comparable or better than the normal geometry devices, showing that the connection structure of vanadium(V)oxide, Ag nanoparticles and zinc(II)oxide functions both as a good recombination...... layer, ensuring serial connection, and as a solvent barrier, protecting the first photoactive layer from processing of the second layer. This successfully demonstrates a tandem solar cell fabrication process fully compatible with state-of-the-art solution based automated production procedures....

  7. Two multichannel integrated circuits for neural recording and signal processing.

    Science.gov (United States)

    Obeid, Iyad; Morizio, James C; Moxon, Karen A; Nicolelis, Miguel A L; Wolf, Patrick D

    2003-02-01

    We have developed, manufactured, and tested two analog CMOS integrated circuit "neurochips" for recording from arrays of densely packed neural electrodes. Device A is a 16-channel buffer consisting of parallel noninverting amplifiers with a gain of 2 V/V. Device B is a 16-channel two-stage analog signal processor with differential amplification and high-pass filtering. It features selectable gains of 250 and 500 V/V as well as reference channel selection. The resulting amplifiers on Device A had a mean gain of 1.99 V/V with an equivalent input noise of 10 microV(rms). Those on Device B had mean gains of 53.4 and 47.4 dB with a high-pass filter pole at 211 Hz and an equivalent input noise of 4.4 microV(rms). Both devices were tested in vivo with electrode arrays implanted in the somatosensory cortex.

  8. Serbia’s EU integration process: The momentum of 2008

    Directory of Open Access Journals (Sweden)

    Ristić Irena

    2009-01-01

    Full Text Available After four years of ambivalence, the relationship between the European Union and Serbia is again gaining a new opportunity to flourish. The new Serbian government is formed by parties which are strongly committed to Serbia’s EU integration and hence ready to carry out reforms and fully cooperate with the International Crime Tribunal for the former Yugoslavia. This paper presents the current relationship between Brussels and Belgrade and its main obstacles. It emphasizes both internal and external problems of this relationship and their interdependency. In this regard the author argues that only by a mutual commitment of both Serbia and the EU lasting peace will be achieved in the Western Balkans and the region stabilized.

  9. Treatment of atrazine by integrating photocatalytic and biological processes

    International Nuclear Information System (INIS)

    Chan, C.Y.; Tao, S.; Dawson, R.; Wong, P.K.

    2004-01-01

    This research examines the degradation of atrazine by photocatalytic oxidation (PCO) under different experimental conditions. Deisopropylatrazine, deethylatrazine and deethyldeisopropylatrazine were formed as major intermediates based on gas chromatography-mass spectrometry. The reaction mixture was found to be toxic towards two bioassays, i.e. the Microtox[reg] and amphipods survival tests even when atrazine was completely degraded by PCO within 2 h under optimized conditions. The results indicate that adding H 2 O 2 could significantly enhance the degradation of atrazine by PCO. Ammeline, ammelide and cyanuric acid (CA) became the major intermediates/products as detected by high performance liquid chromatography from 6th to the 40th h of PCO treatment. After 72 h PCO treatment, only CA was detectable in the reaction mixture. Further degradation of CA was carried out by a newly isolated CA-degrading bacterium, Sphingomonas capsulata. The photochemical pretreatment integrated with microbial degradation lead to the complete degradation and detoxification of atrazine

  10. Asymmetries: a fuzzy topic in the process of integration

    Directory of Open Access Journals (Sweden)

    Jaime Alberto Rendón Acevedo

    2012-12-01

    Full Text Available FTAs have gained prominence in the trade policy of Latin American countries to the detriment of other forms of economic integration. In this trend there is a predominance of south-north schemes, where all kinds of asymmetries are evident. The aim of this paper is to demonstrate that the reduction of asymmetries should be a primary goal of the FTAs. The methodology is a review of literature on Latin American FTAs with the United States, particularly those signed by Mexico, Chile and Colombia. As a result, we see that an appropriate treatment of the differences between involved economies is not only desirable for the development of Latin American countries but also it is possible through monetary and industrial policy adjusted to the reality of these countries.

  11. Integrated System Technologies for Modular Trapped Ion Quantum Information Processing

    Science.gov (United States)

    Crain, Stephen G.

    Although trapped ion technology is well-suited for quantum information science, scalability of the system remains one of the main challenges. One of the challenges associated with scaling the ion trap quantum computer is the ability to individually manipulate the increasing number of qubits. Using micro-mirrors fabricated with micro-electromechanical systems (MEMS) technology, laser beams are focused on individual ions in a linear chain and steer the focal point in two dimensions. Multiple single qubit gates are demonstrated on trapped 171Yb+ qubits and the gate performance is characterized using quantum state tomography. The system features negligible crosstalk to neighboring ions (technologies demonstrated in this thesis can be integrated to form a single quantum register with all of the necessary resources to perform local gates as well as high fidelity readout and provide a photon link to other systems.

  12. Processing bimodal stimuli: Integrality/separability of colour and orientation

    Directory of Open Access Journals (Sweden)

    David eBimler

    2013-10-01

    Full Text Available We examined how two distinct stimulus features, orientation and colour, interact as contributions to global stimulus dissimilarity. Five subjects rated dissimilarity between pairs of bars (N = 30 varying in colour (four cardinal hues, plus white and orientation (six angles at 30° intervals. An exploratory analysis with individual-differences multidimensional scaling resulted in a 5D solution, with two dimensions required to accommodate the circular sequence of the angular attribute, and red-green, blue-yellow and achromatic axes for the colour attribute. Weights of the orientation subspace relative to the colour subspace varied among the subjects, from a 0.32:0.61 ratio to 0.53:0.44, emphasis shifting between colour and orientation. In addition to Euclidean metric, we modelled the interaction of colour and orientation using Minkowski power metrics across a range of Minkowski exponents p, including the city-block (p = 1, Euclidean (p = 2 and Dominance metric (p à ¥ as special cases. For averaged data, p ~ 1.3 provided the best fit, i.e. intermediate between separable and integral features. For individual subjects, however, the metric exponent varied significantly from p = 0.7 to p = 3.1, indicating a subject-specific rule for combining colour and orientation, as in Tversky and Gati’s variable-weights model. No relationship was apparent between dimensional weights and individual p exponents. Factors affecting dimensional integrality are discussed, including possible underlying neural mechanisms where the interaction of the low-level vision attributes orientation and colour might shift between uncorrelated (p =1 or correlated (p ³ 2 forms.

  13. Optimal operation of integrated processes. Studies on heat recovery systems

    Energy Technology Data Exchange (ETDEWEB)

    Glemmestad, Bjoern

    1997-12-31

    Separators, reactors and a heat exchanger network (HEN) for heat recovery are important parts of an integrated plant. This thesis deals with the operation of HENs, in particular, optimal operation. The purpose of heat integration is to save energy, but the HEN also introduces new interactions and feedback into the overall plant. A prerequisite for optimisation is that there are extra degrees of freedom left after regulatory control is implemented. It is shown that extra degrees of freedom may not always be utilized for energy optimisation, and a quantitative expression for the degrees of freedom that can be so utilized are presented. A simplified expression that is often valid is also deduced. The thesis presents some improvements and generalisations of a structure based method that has been proposed earlier. Structural information is used to divide possible manipulations into three categories depending on how each manipulation affects the utility consumption. By means of these categories and two heuristic rules for operability, the possible manipulations are ordered in a priority table. This table is used to determine which manipulation should be preferred and which manipulation should be selected if an active manipulation is saturated. It is shown that the method may correspond to split-range control. A method that uses parametric information in addition to structural information is proposed. In this method, the optimal control structure is found through solving an integer programming problem. The thesis also proposes a method that combines the use of steady state optimisation and optimal selection of measurements. 86 refs., 46 figs., 8 tabs.

  14. Integrated systems for real time data acquisition and processing

    International Nuclear Information System (INIS)

    Oprea, I.; Oprea, M.

    1995-01-01

    The continuous measuring of all the nuclear and dosimetric parameters in a nuclear facility is essential for personnel and environment protection. Considering the vast amount of information and data required to keep an updated overview of a situation the need for an efficient acquisition processing and information system is evident. The paper analyses the special requirements as concerning the real time inter-process communication and proposes a modern concept based on the last trends existing in the field of computer technology and operating systems. (author)

  15. Integrated Ion Exchange Regeneration Process for Drinking Water

    Science.gov (United States)

    2010-04-01

    Nitrate - Destruction 123 5.7.3.3 Sulfate- destruction unit process 125 5.7.3.4 NDMA , NDEA, and NDPA in destruction unit process 127 5.7.3.5 pH...Sampling Results 139 5.7.4.1 Free Chlorine 140 5.7.4.2 Total Organic Halides 141 5.7.4.3 Haloacetic Acids 141 5.7.4.4 Trihalomethane 141 5.7.4.5 NDMA ...Typical Destruction Reactor Nitrate Effluent Profile during First Destruction Cycle Parametric Tests 124 Figure 6-1: Washout of NDMA from Virgin IX

  16. Silicon analog components device design, process integration, characterization, and reliability

    CERN Document Server

    El-Kareh, Badih

    2015-01-01

    This book covers modern analog components, their characteristics, and interactions with process parameters. It serves as a comprehensive guide, addressing both the theoretical and practical aspects of modern silicon devices and the relationship between their electrical properties and processing conditions. Based on the authors’ extensive experience in the development of analog devices, this book is intended for engineers and scientists in semiconductor research, development and manufacturing. The problems at the end of each chapter and the numerous charts, figures and tables also make it appropriate for use as a text in graduate and advanced undergraduate courses in electrical engineering and materials science.

  17. Preliminary paper - Integrated control process for the development of the mined geologic disposal system

    International Nuclear Information System (INIS)

    Daniel, Russell B.; Harbert, Kevin R.; Calloway, David E.

    1997-01-01

    The US Department of Energy (DOE) Order 430.1, Life Cycle Asset Management, begins to focus DOE Programs and Projects on the total system life cycle instead of looking at project execution or operation as individual components. As DOE begins to implement this order, the DOE Management and Operating contractors must develop a process to control not only the contract baseline but also the overall life cycle baseline. This paper presents an integrated process that is currently being developed on the Yucca Mountain Project for DOE. The process integrates the current contract/project baseline management process with the management control process for design and the configuration management change control process

  18. The Effect of Information Security Management on Organizational Processes Integration in Supply Chain

    Directory of Open Access Journals (Sweden)

    Mohsen Shafiei Nikabadi

    2012-03-01

    Full Text Available : The major purpose of this article was that how information security management has effect on supply chain integration and the effect of implementing "information security management system" on enhancing supplies chain integration. In this respect, current research was seeking a combination overview to these tow approaches (Information Security Management and Organizational Processes Integration by Enterprise Resources Planning System and after that determined factors of these two important issue by factor analysis. Researchers using a series of comments in the automotive experts (production planning and management and supply chain experts and caregivers car makers and suppliers in the first level and second level supply chain industry. In this way, it has been done that impact on how information security management processes enterprise supply chain integration with the help of statistical correlation analysis. The results of this investigation indicated effect of "information security management system" various dimensions that were coordination of information, prevent human errors and hardware, the accuracy of information and education for users on two dimensions of internal and external integration of business processes, supply chain and finally, it can increased integration of business processes in supply chain. At the end owing to quite these results, deployment of "information security management system" increased the integration of organizational processes in supply chain. It could be demonstrate with the consideration of relation of organizational integration processes whit the level of coordination of information, prevent errors and accuracy of information throughout the supply chain.

  19. Conceptual information processing: A robust approach to KBS-DBMS integration

    Science.gov (United States)

    Lazzara, Allen V.; Tepfenhart, William; White, Richard C.; Liuzzi, Raymond

    1987-01-01

    Integrating the respective functionality and architectural features of knowledge base and data base management systems is a topic of considerable interest. Several aspects of this topic and associated issues are addressed. The significance of integration and the problems associated with accomplishing that integration are discussed. The shortcomings of current approaches to integration and the need to fuse the capabilities of both knowledge base and data base management systems motivates the investigation of information processing paradigms. One such paradigm is concept based processing, i.e., processing based on concepts and conceptual relations. An approach to robust knowledge and data base system integration is discussed by addressing progress made in the development of an experimental model for conceptual information processing.

  20. Methodology for optimization of process integration schemes in a biorefinery under uncertainty

    International Nuclear Information System (INIS)

    Marta Abreu de las Villas (Cuba))" data-affiliation=" (Departamento de Ingeniería Química. Facultad de Química y Farmacia. Universidad Central Marta Abreu de las Villas (Cuba))" >González-Cortés, Meilyn; Marta Abreu de las Villas (Cuba))" data-affiliation=" (Departamento de Ingeniería Química. Facultad de Química y Farmacia. Universidad Central Marta Abreu de las Villas (Cuba))" >Martínez-Martínez, Yenisleidys; Marta Abreu de las Villas (Cuba))" data-affiliation=" (Departamento de Ingeniería Química. Facultad de Química y Farmacia. Universidad Central Marta Abreu de las Villas (Cuba))" >Albernas-Carvajal, Yailet; Marta Abreu de las Villas (Cuba))" data-affiliation=" (Departamento de Ingeniería Química. Facultad de Química y Farmacia. Universidad Central Marta Abreu de las Villas (Cuba))" >Pedraza-Garciga, Julio; Marta Abreu de las Villas (Cuba))" data-affiliation=" (Departamento de Ingeniería Química. Facultad de Química y Farmacia. Universidad Central Marta Abreu de las Villas (Cuba))" >Morales-Zamora, Marlen

    2017-01-01

    The uncertainty has a great impact in the investment decisions, operability of the plants and in the feasibility of integration opportunities in the chemical processes. This paper, presents the steps to consider the optimization of process investment in the processes integration under conditions of uncertainty. It is shown the potentialities of the biomass cane of sugar for the integration with several plants in a biorefinery scheme for the obtaining chemical products, thermal and electric energy. Among the factories with potentialities for this integration are the pulp and paper and sugar factories and other derivative processes. Theses factories have common resources and also have a variety of products that can be exchange between them so certain products generated in a one of them can be raw matter in another plant. The methodology developed guide to obtaining of feasible investment projects under uncertainty. As objective function was considered the maximization of net profitable value in different scenarios that are generated from the integration scheme. (author)

  1. Economic Benefit from Progressive Integration of Scheduling and Control for Continuous Chemical Processes

    Directory of Open Access Journals (Sweden)

    Logan D. R. Beal

    2017-12-01

    Full Text Available Performance of integrated production scheduling and advanced process control with disturbances is summarized and reviewed with four progressive stages of scheduling and control integration and responsiveness to disturbances: open-loop segregated scheduling and control, closed-loop segregated scheduling and control, open-loop scheduling with consideration of process dynamics, and closed-loop integrated scheduling and control responsive to process disturbances and market fluctuations. Progressive economic benefit from dynamic rescheduling and integrating scheduling and control is shown on a continuously stirred tank reactor (CSTR benchmark application in closed-loop simulations over 24 h. A fixed horizon integrated scheduling and control formulation for multi-product, continuous chemical processes is utilized, in which nonlinear model predictive control (NMPC and continuous-time scheduling are combined.

  2. Review of Exploration Systems Development (ESD) Integrated Hazard Development Process. Appendices; Volume 2

    Science.gov (United States)

    Smiles, Michael D.; Blythe, Michael P.; Bejmuk, Bohdan; Currie, Nancy J.; Doremus, Robert C.; Franzo, Jennifer C.; Gordon, Mark W.; Johnson, Tracy D.; Kowaleski, Mark M.; Laube, Jeffrey R.

    2015-01-01

    The Chief Engineer of the Exploration Systems Development (ESD) Office requested that the NASA Engineering and Safety Center (NESC) perform an independent assessment of the ESD's integrated hazard development process. The focus of the assessment was to review the integrated hazard analysis (IHA) process and identify any gaps/improvements in the process (e.g. missed causes, cause tree completeness, missed hazards). This document contains the outcome of the NESC assessment.

  3. Review of Exploration Systems Development (ESD) Integrated Hazard Development Process. Volume 1; Appendices

    Science.gov (United States)

    Smiles, Michael D.; Blythe, Michael P.; Bejmuk, Bohdan; Currie, Nancy J.; Doremus, Robert C.; Franzo, Jennifer C.; Gordon, Mark W.; Johnson, Tracy D.; Kowaleski, Mark M.; Laube, Jeffrey R.

    2015-01-01

    The Chief Engineer of the Exploration Systems Development (ESD) Office requested that the NASA Engineering and Safety Center (NESC) perform an independent assessment of the ESD's integrated hazard development process. The focus of the assessment was to review the integrated hazard analysis (IHA) process and identify any gaps/improvements in the process (e.g., missed causes, cause tree completeness, missed hazards). This document contains the outcome of the NESC assessment.

  4. Trends And Economic Assessment Of Integration Processes At The Metal Market

    OpenAIRE

    Olga Aleksandrovna Romanova; Eduard Vyacheslavovich Makarov

    2015-01-01

    The article discussed the integration process from the perspective of three dimensions that characterize the corresponding increase in the number and appearance of new relationships; strength, character, and stability of emerging communications; dynamics and the appropriate form of the process. In the article, trends of development of integration processes in metallurgy are identified, identification of five stages of development in Russian metal trading are justified. We propose a s...

  5. Development Trends And Economic Assessment Of The Integration Processes On The Metals Market

    OpenAIRE

    Romanova, Olga A.; Makarov, Eduard V.

    2018-01-01

    The article examines the integration process from the perspective of three dimensions, which characterize the increase in quantity and appearance of new relationships; strength, character and stability of emerging communications; dynamics and the proper form of the process. The authors identify the development trends of the integration processes in the metals market and provide justification for the breaking of the period of Russian metal trading for 1991–2016 into five stages of development....

  6. Power up your plant - An introduction to integrated process and power automation

    Energy Technology Data Exchange (ETDEWEB)

    Vasel, Jeffrey

    2010-09-15

    This paper discusses how a single integrated system can increase energy efficiency, improve plant uptime, and lower life cycle costs. Integrated Process and Power Automation is a new system integration architecture and power strategy that addresses the needs of the process and power generation industries. The architecture is based on Industrial Ethernet standards such as IEC 61850 and Profinet as well as Fieldbus technologies. The energy efficiency gains from integration are discussed in a power generation use case. A power management system success story from a major oil and gas company, Petrobras, is also discussed.

  7. Integrated Gis-remote sensing processing applied to vegetation ...

    African Journals Online (AJOL)

    A remotely sensed digital image of SPOT by its linear enhancement on a large memory, high speed, and digital electronic computer revealed from false colour composite that vegetation is expressed as red. Further processing of SPOT digital image for arithmetic banding of Normalized Differential Vegetation Index (NDVI) ...

  8. Bologna Process Principles Integrated into Education System of Kazakhstan

    Science.gov (United States)

    Nessipbayeva, Olga

    2013-01-01

    The purpose of this paper is to analyze the fulfillment of the parameters of the Bologna Process in the education system of Kazakhstan. The author gives short review of higher education system of the Republic of Kazakhstan with necessary data. And the weaknesses of the system of higher education are identified. Moreover, implementing…

  9. A General Representation Theorem for Integrated Vector Autoregressive Processes

    DEFF Research Database (Denmark)

    Franchi, Massimo

    We study the algebraic structure of an I(d) vector autoregressive process, where d is restricted to be an integer. This is useful to characterize its polynomial cointegrating relations and its moving average representation, that is to prove a version of the Granger representation theorem valid...

  10. Employee Selection Process: Integrating Employee Needs and Employer Motivators.

    Science.gov (United States)

    Carroll, Brian J.

    1989-01-01

    Offers suggestions for managers relative to the employee selection process, focusing on the identification of a potential employee's needs and the employer's motivators that affect employee productivity. Discusses the use of a preemployment survey and offers a questionnaire that allows matching of the employee's needs with employment…

  11. Poisson processes on groups and Feynamn path integrals

    International Nuclear Information System (INIS)

    Combe, P.; Rodriguez, R.; Aix-Marseille-2 Univ., 13 - Marseille; Sirugue, M.; Sirugue-Collin, M.; Centre National de la Recherche Scientifique, 13 - Marseille; Hoegh-Krohn, R.

    1980-01-01

    We give an expression for the perturbed evolution of a free evolution by gentle, possibly velocity dependent, potential, in terms of the expectation with respect to a Poisson process on a group. Various applications are given in particular to usual quantum mechanics but also to Fermi and spin systems. (orig.)

  12. Poisson processes on groups and Feynman path integrals

    International Nuclear Information System (INIS)

    Combe, P.; Rodriguez, R.; Sirugue-Collin, M.; Centre National de la Recherche Scientifique, 13 - Marseille; Sirugue, M.

    1979-09-01

    An expression is given for the perturbed evolution of a free evolution by gentle, possibly velocity dependent, potential, in terms of the expectation with respect to a Poisson process on a group. Various applications are given in particular to usual quantum mechanics but also to Fermi and spin systems

  13. Thermochemical Process Integration, Scale-Up, and Piloting Publications |

    Science.gov (United States)

    ) Material and Energy Balances Capital and Operating Cost Estimates Discounted Cash Flow Analysis Minimal Estimates; and Project Financing Assumptions Discounted Cash Flow Analysis. Enlarge image Process Design and model at lower alcohol synthesis pressure with respect to the design case. Costs include Capital

  14. Integrating reuse measurement practices into the ERP requirements engineering process

    NARCIS (Netherlands)

    Daneva, Maia; Münich, Jürgen; Vierimaa, Matias

    2006-01-01

    The management and deployment of reuse-driven and architecturecentric requirements engineering processes have become common in many organizations adopting Enterprise Resource Planning solutions. Yet, little is known about the variety of reusability aspects in ERP projects at the level of

  15. Why wait? : Organizing integrated processes in cancer care

    NARCIS (Netherlands)

    Leeftink, Anne Greetje

    2017-01-01

    The access to cancer diagnostics and cancer treatment is not the same for all types of cancer patients. Furthermore, the resources involved in these processes are costly and scarce. Long access and waiting times to diagnostics and treatment can cause increased anxiety of patients. The goal of this

  16. Water-integrated scheduling of batch process plants

    NARCIS (Netherlands)

    Pulluru, Sai Jishna; Akkerman, Renzo

    2017-01-01

    Efficient water management is becoming increasingly important in production systems, but companies often do not have any concrete strategies to implement. While there are numerous technological options for improving water efficiency in process plants, there is a lack of effective decision support to

  17. Water-integrated scheduling of batch process plants

    NARCIS (Netherlands)

    Pulluru, Sai Jishna; Akkerman, Renzo

    2018-01-01

    Efficient water management is becoming increasingly important in production systems, but companies often do not have any concrete strategies to implement. While there are numerous technological options for improving water efficiency in process plants, there is a lack of effective decision support to

  18. The Development and Application of an Integrated VAR Process Model

    Science.gov (United States)

    Ballantyne, A. Stewart

    2016-07-01

    The VAR ingot has been the focus of several modelling efforts over the years with the result that the thermal regime in the ingot can be simulated quite realistically. Such models provide important insight into solidification of the ingot but present some significant challenges to the casual user such as a process engineer. To provide the process engineer with a tool to assist in the development of a melt practice, a comprehensive model of the complete VAR process has been developed. A radiation heat transfer simulation of the arc has been combined with electrode and ingot models to develop a platform which accepts typical operating variables (voltage, current, and gap) together with process parameters (electrode size, crucible size, orientation, water flow, etc.) as input data. The output consists of heat flow distributions and solidification parameters in the form of text, comma-separated value, and visual toolkit files. The resulting model has been used to examine the relationship between the assumed energy distribution in the arc and the actual energy flux which arrives at the ingot top surface. Utilizing heat balance information generated by the model, the effects of electrode-crucible orientation and arc gap have been explored with regard to the formation of ingot segregation defects.

  19. Managing uncertainty in fi shing and processing of an integrated ...

    African Journals Online (AJOL)

    The firm attempts to manage this uncertainty through planning co-ordination of fishing trawler scheduling, catch quota, processing and labour allocation, and inventory control. Schedules must necessarily be determined over some finite planning time horizon, and the trawler schedule itself introduces man-made variability, ...

  20. DEMONSTRATION OF AN INTEGRATED, PASSIVE BIOLOGICAL TREATMENT PROCESS FOR AMD

    Science.gov (United States)

    An innovative, cost-effective, biological treatment process has been designed by MSE Technology Applications, Inc. to treat acid mine drainage (AMD). A pilot-scale demonstration is being conducted under the Mine Waste Technology Program using water flowing from an abandoned mine ...

  1. Process cells dismantling of EUREX pant: previous activities

    International Nuclear Information System (INIS)

    Gili, M.

    1998-01-01

    In the '98-'99 period some process cells of the EUREX pant will be dismantled, in order to place there the liquid wastes conditioning plant 'CORA'. This report resumes the previous activities (plant rinsing campaigns and inactive Cell 014 dismantling), run in the past three years and the drawn experience [it

  2. Repair processes for photochemical damage in mammalian cells

    International Nuclear Information System (INIS)

    Cleaver, J.E.

    1974-01-01

    Repair processes for photochemical damage in cells following uv irradiation are reviewed. Cultured fibroblast cells from human patients with xeroderma pigmentosum were used as an example to illustrate aspects of repair of injuries to DNA and proteins. (250 references) (U.S.)

  3. Integrating textual and model-based process descriptions for comprehensive process search

    NARCIS (Netherlands)

    Leopold, Henrik; van der Aa, Han; Pittke, Fabian; Raffel, Manuel; Mendling, Jan; Reijers, Hajo A.

    2016-01-01

    Documenting business processes using process models is common practice in many organizations. However, not all process information is best captured in process models. Hence, many organizations complement these models with textual descriptions that specify additional details. The problem with this

  4. Hydrogen and fuel cell research: Institute for Integrated Energy Systems (IESVic)

    International Nuclear Information System (INIS)

    Pitt, L.

    2006-01-01

    Vision: IESVic's mission is to chart feasible paths to sustainable energy. Current research areas of investigation: 1. Energy system analysis 2. Computational fuel cell engineering; Fuel cell parameter measurement; Microscale fuel cells 3. Hydrogen dispersion studies for safety codes 4. Active magnetic refrigeration for hydrogen liquifaction and heat transfer in metal hydrides 5. Hydrogen and fuel cell system integration (author)

  5. Pectic arabinan side chains are essential for pollen cell wall integrity during pollen development

    DEFF Research Database (Denmark)

    Cankar, Katarina; Kortstee, Anne; Toonen, Marcel A.J.

    2014-01-01

    Pectin is a complex polysaccharide and an integral part of the primary plant cell wall and middle lamella, contributing to cell wall mechanical strength and cell adhesion. To understand the structure-function relationships of pectin in the cell wall, a set of transgenic potato lines with altered...

  6. Hydrogen, fuel cells and renewable energy integration in islands

    International Nuclear Information System (INIS)

    Bauen, A.; Hart, D.; Foradini, F.; Hart, D.

    2002-01-01

    Remote areas such as islands rely on costly and highly polluting diesel and heavy fuel oil for their electricity supply. This paper explored the opportunities for exploiting economically and environmentally viable renewable energy sources, in particular hydrogen storage, on such islands. In particular, this study focused on addressing the challenge of matching energy supply with demand and with technical issues regarding weak grids that are hindered with high steady state voltage levels and voltage fluctuations. The main technical characteristics of integrated renewable energy and hydrogen systems were determined by modelling a case study for the island of El Hierro (Canary Islands). The paper referred to the challenges regarding the technical and economic viability of such systems and their contribution to the economic development of remote communities. It was noted that energy storage plays an important role in addressing supply and demand issues by offering a way to control voltage and using surplus electricity at times of low load. Electrical energy can be stored in the form of potential or chemical energy. New decentralized generation technologies have also played a role in improving the energy efficiency of renewable energy sources. The feasibility of using hydrogen for energy storage was examined with particular reference to fuel-cell based energy supply in isolated island communities. 4 refs., 5 figs

  7. Performance analysis of solar energy integrated with natural-gas-to-methanol process

    International Nuclear Information System (INIS)

    Yang, Sheng; Liu, Zhiqiang; Tang, Zhiyong; Wang, Yifan; Chen, Qianqian; Sun, Yuhan

    2017-01-01

    Highlights: • Solar energy integrated with natural-gas-to-methanol process is proposed. • The two processes are modeled and simulated. • Performance analysis of the two processes are conducted. • The proposed process can cut down the greenhouse gas emission. • The proposed process can save natural gas consumption. - Abstract: Methanol is an important platform chemical. Methanol production using natural gas as raw material has short processing route and well developed equipment and technology. However, natural gas reserves are not large in China. Solar energy power generation system integrated with natural-gas-to-methanol (NGTM) process is developed, which may provide a technical routine for methanol production in the future. The solar energy power generation produces electricity for reforming unit and system consumption in solar energy integrated natural-gas-to-methanol system (SGTM). Performance analysis of conventional natural-gas-to-methanol process and solar energy integrated with natural-gas-to-methanol process are presented based on simulation results. Performance analysis was conducted considering carbon efficiency, production cost, solar energy price, natural gas price, and carbon tax. Results indicate that solar energy integrated with natural-gas-to-methanol process is able to cut down the greenhouse gas (GHG) emission. In addition, solar energy can replace natural gas as fuel. This can reduce the consumption of natural gas, which equals to 9.2% of the total consumed natural gas. However, it is not economical considering the current technology readiness level, compared with conventional natural-gas-to-methanol process.

  8. Enhancing Business Process Automation by Integrating RFID Data and Events

    Science.gov (United States)

    Zhao, Xiaohui; Liu, Chengfei; Lin, Tao

    Business process automation is one of the major benefits for utilising Radio Frequency Identification (RFID) technology. Through readers to RFID middleware systems, the information and the movements of tagged objects can be used to trigger business transactions. These features change the way of business applications for dealing with the physical world from mostly quantity-based to object-based. Aiming to facilitate business process automation, this paper introduces a new method to model and incorporate business logics into RFID edge systems from an object-oriented perspective with emphasises on RFID's event-driven characteristics. A framework covering business rule modelling, event handling and system operation invocations is presented on the basis of the event calculus. In regard to the identified delayed effects in RFID-enabled applications, a two-block buffering mechanism is proposed to improve RFID query efficiency within the framework. The performance improvements are analysed with related experiments.

  9. Virtual Welded - Joint Design Integrating Advanced Materials and Processing Technology

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Zhishang; Ludewig, Howard W.; Babu, S. Suresh

    2005-06-30

    Virtual Welede-Joint Design, a systematic modeling approach, has been developed in this project to predict the relationship of welding process, microstructure, properties, residual stress, and the ultimate weld fatique strength. This systematic modeling approach was applied in the welding of high strength steel. A special welding wire was developed in this project to introduce compressive residual stress at weld toe. The results from both modeling and experiments demonstrated that more than 10x fatique life improvement can be acheived in high strength steel welds by the combination of compressive residual stress from the special welding wire and the desired weld bead shape from a unique welding process. The results indicate a technology breakthrough in the design of lightweight and high fatique performance welded structures using high strength steels.

  10. About Hydrodynamic Limit of Some Exclusion Processes via Functional Integration

    OpenAIRE

    Fayolle , Guy; Furtlehner , Cyril

    2011-01-01

    Proceedings on CD. ISBN 978-5-901158-15-9; International audience; This article considers some classes of models dealing with the dynamics of discrete curves subjected to stochastic deformations. It turns out that the problems of interest can be set in terms of interacting exclusion processes, the ultimate goal being to derive hydrodynamic limits after proper scalings. A seemingly new method is proposed, which relies on the analysis of specific partial differential operators, involving variat...

  11. Surviving security how to integrate people, process, and technology

    CERN Document Server

    Andress, Amanda

    2003-01-01

    WHY DO I NEED SECURITY? Introduction The Importance of an Effective Security Infrastructure People, Process, and Technology What Are You Protecting Against? Types of Attacks Types of Attackers Security as a Competitive Advantage Choosing a Solution Finding Security Employees The Layered Approach UNDERSTANDING REQUIREMENTS AND RISK What Is Risk? Embracing Risk Information Security Risk Assessment Assessing Risk Insurance SECURITY POLICIES AND PROCEDURES Internal Focus Is Key Security Awareness and Education Policy Life Cycle Developing Policies Components of a Security Policy Sample Security Po

  12. Integration of Environmental Planning Into the Army Master Planning Process

    Science.gov (United States)

    1992-10-01

    the issues specific to the later assessment (ETL 1110-3-407, pp 1-9 to 1-10). Under the : estructured master planning process discussed in this report...Lisa~m 0111utHars M143 AMW PRO*b LAMM~e 0)3. AMW uaides, Uso ~ow (M Port RJ." 21719 7%s pubhicaton was repfodaaced on moycled V&Mp. /| / 121 DATEI:

  13. Integrated copper-containing wastewater treatment using xanthate process.

    Science.gov (United States)

    Chang, Yi-Kuo; Chang, Juu-En; Lin, Tzong-Tzeng; Hsu, Yu-Ming

    2002-09-02

    Although, the xanthate process has been shown to be an effective method for heavy metal removal from contaminated water, a heavy metal contaminated residual sludge is produced by the treatment process and the metal-xanthate sludge must be handled in accordance with the Taiwan EPA's waste disposal requirements. This work employed potassium ethyl xanthate (KEX) to remove copper ions from wastewater. The toxicity characteristic leaching procedure (TCLP) and semi-dynamic leaching test (SDLT) were used to determine the leaching potential and stability characteristics of the residual copper xanthate (Cu-EX) complexes. Results from metal removal experiments showed that KEX was suitable for the treatment of copper-containing wastewater over a wide copper concentration range (50, 100, 500, and 1000 mg/l) to the level that meets the Taiwan EPA's effluent regulations (3mg/l). The TCLP results of the residual Cu-EX complexes could meet the current regulations and thus the Cu-EX complexes could be treated as a non-hazardous material. Besides, the results of SDLT indicated that the complexes exhibited an excellent performance for stabilizing metals under acidic conditions, even slight chemical changes of the complexes occurred during extraction. The xanthate process, mixing KEX with copper-bearing solution to form Cu-EX precipitates, offered a comprehensive strategy for solving both copper-containing wastewater problems and subsequent sludge disposal requirements.

  14. Processing horizontal networks measured by integrated terrestrial and GPS technologies

    Directory of Open Access Journals (Sweden)

    Vincent Jakub

    2003-09-01

    Full Text Available Local horizontal networks in which GPS and terrestrial measurements (TER are done are often established at present. Iin other networks, the previous terrestrial measurements can be completed with quantities from contemporary GPS observations (tunnel nets, mining nets with surface and underground parts and other long-shaped nets.The processing of such heterobeneous (GPS, TER networks whose terrestrial measurements are performed as point coordinate measurements (∆X, ∆Y using (geodetic total stationIn is presented in this paper. In such network structures it is then available:- the values ∆X, ∆Y from TER observations which are transformed in the plane of S-JTSK for adjustement,- the values ∆X, ∆Y in the plane S-JTSK that can be obtained by 3D transformation of WGS84 netpoint coordinates from GPS observations to corresponding coordinates S-JTSK.For common adjusting all the ∆X, ∆Y, some elements of the network geometry (e.g. distances should be measured by both methods (GPS, TER. This approach makes possible an effective homogenisation of both network parts what is equivalent to saying that an expressive influence reduction on local frame realizations of S-JTSK in the whole network can be made.Results of network processing obtained in proposed manner are acceptable in general and they are equivalent (accuracy, reliability to results of another processing methods.

  15. Evaluation of integrated biotreatment processes for in situ application

    International Nuclear Information System (INIS)

    Maher, A.; Lamptey, J.C.; Kennel, N.D.

    1994-01-01

    Petroleum hydrocarbon contamination of soils and groundwater associated with Underground Storage Tanks (UST) and aboveground fuel spills has become the focus of many bioremediation efforts. Two case studies in the application of in situ bioremediation to degrade petroleum hydrocarbons are presented. Site A has a history of fuel-handling practices associated with bulk petroleum storage and railroad yard activities. The majority of the hydrocarbon contamination appeared to be the result of past surface spills. Pre-treatment investigation indicated the presence of both volatile and semi- or non-volatile hydrocarbons in the soil. About 3,000 cubic yards of highly contaminated soils was excavated and is being treated in 2, lined, closed loop treatment cells. Groundwater is treated in situ with addition of nutritional cofactors and oxygen introduced through 3 infiltration galleries that are placed 6 feet deep and are each 100 feet in length. Groundwater is also recovered from 3 extraction wells placed 80 to 100 feet from each other, and subsequently treated in a bioreactor. Site B has a history of leaking underground gasoline storage tanks and spills from aboveground diesel fuel associated with county maintenance shed activities. One hundred cubic yards of soil contaminated with diesel components were excavated and treated aboveground in a lined cell. Gasoline contaminated groundwater and soil is being treated in situ by the addition of nutritional cofactors and oxygen through an infiltration gallery 4 feet below surface. The groundwater is recovered from an extraction gallery 92.5 feet down gradient of the infiltration gallery. Nutritional cofactors are introduced on a daily basis with on-site controls. Hydrocarbon reduction, up to 76%, was observed within 3 months of treatment startup in monitoring wells

  16. Integrating technology into complex intervention trial processes: a case study.

    Science.gov (United States)

    Drew, Cheney J G; Poile, Vincent; Trubey, Rob; Watson, Gareth; Kelson, Mark; Townson, Julia; Rosser, Anne; Hood, Kerenza; Quinn, Lori; Busse, Monica

    2016-11-17

    Trials of complex interventions are associated with high costs and burdens in terms of paperwork, management, data collection, validation, and intervention fidelity assessment occurring across multiple sites. Traditional data collection methods rely on paper-based forms, where processing can be time-consuming and error rates high. Electronic source data collection can potentially address many of these inefficiencies, but has not routinely been used in complex intervention trials. Here we present the use of an on-line system for managing all aspects of data handling and for the monitoring of trial processes in a multicentre trial of a complex intervention. We custom built a web-accessible software application for the delivery of ENGAGE-HD, a multicentre trial of a complex physical therapy intervention. The software incorporated functionality for participant randomisation, data collection and assessment of intervention fidelity. It was accessible to multiple users with differing levels of access depending on required usage or to maintain blinding. Each site was supplied with a 4G-enabled iPad for accessing the system. The impact of this system was quantified through review of data quality and collation of feedback from site coordinators and assessors through structured process interviews. The custom-built system was an efficient tool for collecting data and managing trial processes. Although the set-up time required was significant, using the system resulted in an overall data completion rate of 98.5% with a data query rate of 0.1%, the majority of which were resolved in under a week. Feedback from research staff indicated that the system was highly acceptable for use in a research environment. This was a reflection of the portability and accessibility of the system when using the iPad and its usefulness in aiding accurate data collection, intervention fidelity and general administration. A combination of commercially available hardware and a bespoke online database

  17. Thermochemical production of liquid fuels from biomass: Thermo-economic modeling, process design and process integration analysis

    International Nuclear Information System (INIS)

    Tock, Laurence; Gassner, Martin; Marechal, Francois

    2010-01-01

    A detailed thermo-economic model combining thermodynamics with economic analysis and considering different technological alternatives for the thermochemical production of liquid fuels from lignocellulosic biomass is presented. Energetic and economic models for the production of Fischer-Tropsch fuel (FT), methanol (MeOH) and dimethyl ether (DME) by means of biomass drying with steam or flue gas, directly or indirectly heated fluidized bed or entrained flow gasification, hot or cold gas cleaning, fuel synthesis and upgrading are reviewed and developed. The process is integrated and the optimal utility system is computed. The competitiveness of the different process options is compared systematically with regard to energetic, economic and environmental considerations. At several examples, it is highlighted that process integration is a key element that allows for considerably increasing the performance by optimal utility integration and energy conversion. The performance computations of some exemplary technology scenarios of integrated plants yield overall energy efficiencies of 59.8% (crude FT-fuel), 52.5% (MeOH) and 53.5% (DME), and production costs of 89, 128 and 113 Euro MWh -1 on fuel basis. The applied process design approach allows to evaluate the economic competitiveness compared to fossil fuels, to study the influence of the biomass and electricity price and to project for different plant capacities. Process integration reveals in particular potential energy savings and waste heat valorization. Based on this work, the most promising options for the polygeneration of fuel, power and heat will be determined in a future thermo-economic optimization.

  18. On controllability of an integrated bioreactor and periodically operated membrane separation process

    DEFF Research Database (Denmark)

    Prado Rubio, Oscar Andres; Jørgensen, Sten Bay; Jonsson, Gunnar Eigil

    the influence of membrane fouling. Previously, the REED and fermentation processes have been modeled and investigated separately (Prado- Rubio et al., 2011a; Boonmee, 2003). Additionally, a simple quasi-sequential strategy for integrated process design and control structure development has been proposed (Prado...... to understand the controlled operation of the integrated process, it is convenient to use a model based approach supported by experimental evidence. Recently, an integrated bioreactor and electrically driven membrane separation process (Reverse Electro- Enhanced Dialysis - REED) has been proposed as a method...... at a certain lactate concentration level. Hence, productivity can be enhanced by the in situ lactate removal from the cultivation broth during pH controlled fermentation. This can be done by means of ion exchange membranes and electrical potential gradients. The novelty of the integrated process lies...

  19. Integrating ergonomics in design processes: a case study within an engineering consultancy firm.

    Science.gov (United States)

    Sørensen, Lene Bjerg; Broberg, Ole

    2012-01-01

    This paper reports on a case study within an engineering consultancy firm, where engineering designers and ergonomists were working together on the design of a new hospital sterile processing plant. The objective of the paper is to gain a better understanding of the premises for integrating ergonomics into engineering design processes and how different factors either promote or limit the integration. Based on a grounded theory approach a model illustrating these factors is developed and different hypotheses about how these factors either promote and/or limit the integration of ergonomics into design processes is presented along with the model.

  20. The process of the electric integration in Europe and the lessons for Latin America

    International Nuclear Information System (INIS)

    Orjuela Velez, Jaime A

    2007-01-01

    With the objective of extracting some lessons that serve from reference to the Latin American process of electric integration in course, this article of academic character presents a brief description and analysis of the case of the integration of the electric industry in Europe in the mark of the process of energy integration in that region, starting from the study of three fundamental aspects of this process: the institutional evolution, the macro economic context and the regional politics in energy matter, from the years 50 up to the 90

  1. Galvanic cell for processing of used nuclear fuel

    Science.gov (United States)

    Garcia-Diaz, Brenda L.; Martinez-Rodriguez, Michael J.; Gray, Joshua R.; Olson, Luke C.

    2017-02-07

    A galvanic cell and methods of using the galvanic cell is described for the recovery of uranium from used nuclear fuel according to an electrofluorination process. The galvanic cell requires no input energy and can utilize relatively benign gaseous fluorinating agents. Uranium can be recovered from used nuclear fuel in the form of gaseous uranium compound such as uranium hexafluoride, which can then be converted to metallic uranium or UO.sub.2 and processed according to known methodology to form a useful product, e.g., fuel pellets for use in a commercial energy production system.

  2. A Rapid Cell Expansion Process for Production of Engineered Autologous CAR-T Cell Therapies.

    Science.gov (United States)

    Lu, Tangying Lily; Pugach, Omar; Somerville, Robert; Rosenberg, Steven A; Kochenderfer, James N; Better, Marc; Feldman, Steven A

    2016-12-01

    The treatment of B-cell malignancies by adoptive cell transfer (ACT) of anti-CD19 chimeric antigen receptor T cells (CD19 CAR-T) has proven to be a highly successful therapeutic modality in several clinical trials. 1-6 The anti-CD19 CAR-T cell production method used to support initial trials relied on numerous manual, open process steps, human serum, and 10 days of cell culture to achieve a clinical dose. 7 This approach limited the ability to support large multicenter clinical trials, as well as scale up for commercial cell production. Therefore, studies were completed to streamline and optimize the original National Cancer Institute production process by removing human serum from the process in order to minimize the risk of viral contamination, moving process steps from an open system to functionally closed system operations in order to minimize the risk of microbial contamination, and standardizing additional process steps in order to maximize process consistency. This study reports a procedure for generating CD19 CAR-T cells in 6 days, using a functionally closed manufacturing process and defined, serum-free medium. This method is able to produce CD19 CAR-T cells that are phenotypically and functionally indistinguishable from cells produced for clinical trials by the previously described production process.

  3. Process Improvement Through Tool Integration in Aero-Mechanical Design

    Science.gov (United States)

    Briggs, Clark

    2010-01-01

    Emerging capabilities in commercial design tools promise to significantly improve the multi-disciplinary and inter-disciplinary design and analysis coverage for aerospace mechanical engineers. This paper explores the analysis process for two example problems of a wing and flap mechanical drive system and an aircraft landing gear door panel. The examples begin with the design solid models and include various analysis disciplines such as structural stress and aerodynamic loads. Analytical methods include CFD, multi-body dynamics with flexible bodies and structural analysis. Elements of analysis data management, data visualization and collaboration are also included.

  4. Integrated electronic device for processing impulses from neutron detectors

    International Nuclear Information System (INIS)

    Stoica, Mihai; Pirvu, Ion

    2009-01-01

    The developing of nuclear power is a key factor in decreasing energy Romania's dependence on imports of fossil fuels (oil, natural gas). An important point in achieving this goal is to use the experience acquired in the design and use of the equipment produced with the participation of INR specialists for Cernavoda NPP, Units 1 and 2. The design based on Surface Mount Technology (SMT) and the implementation of electronic interface modules of computer processing and detectors of radiation or nuclear particles contribute both to modernize and increase the performance of equipment. (authors)

  5. Thermodynamic analysis and optimization of IT-SOFC-based integrated coal gasification fuel cell power plants

    NARCIS (Netherlands)

    Romano, M.C.; Campanari, S.; Spallina, V.; Lozza, G.

    2011-01-01

    This work discusses the thermodynamic analysis of integrated gasification fuel cell plants, where a simple cycle gas turbine works in a hybrid cycle with a pressurized intermediate temperature–solid oxide fuel cell (SOFC), integrated with a coal gasification and syngas cleanup island and a bottoming

  6. Heat and work integration: Fundamental insights and applications to carbon dioxide capture processes

    International Nuclear Information System (INIS)

    Fu, Chao; Gundersen, Truls

    2016-01-01

    Highlights: • The problem definition of heat and work integration is introduced. • The fundamental insights of heat and work integration are presented. • The design methodology is illustrated with two small test examples. • Applications of to three carbon dioxide capture processes are presented. - Abstract: The integration of heat has achieved a notable success in the past decades. Pinch Analysis is a well-established methodology for heat integration. Work is an equally important thermodynamic parameter. The enthalpy of a process stream can be changed by the transfer of heat and/or work. Heat and work are actually interchangeable and can thus be integrated. For example, compression processes consume more work at higher temperatures, however, the compression heat may be upgraded and utilized; expansion processes produce more work at higher temperatures, however, more heat may be required. The classical heat integration problem is thus extended to a new research topic about the integration of both heat and work. The aim of this paper is to present the problem definition, fundamental thermodynamic insights and industrial applications of heat and work integration. The results from studies on the three carbon dioxide capture processes show that significant energy savings can be achieved by proper heat and work integration. In the oxy-combustion process, the work consumption for cryogenic air separation is reduced by 10.1%. In the post-combustion membrane separation process, the specific work consumption for carbon dioxide separation is reduced by 12.9%. In the membrane air separation process, the net work consumption (excluding heat consumption) is reduced by 90%.

  7. Integrating anammox with the autotrophic denitrification process via electrochemistry technology.

    Science.gov (United States)

    Qiao, Sen; Yin, Xin; Zhou, Jiti; Wei, Li'e; Zhong, Jiayou

    2018-03-01

    In this study, an autotrophic denitrification process was successfully coupled with anammox to remove the nitrate by-product via electrochemical technology. When the voltage applied to the combined electrode reactor was 1.5 V, the electrode reaction removed nitrate by using the autotrophic denitrification biomass without affecting the anammox biomass. The nitrogen removal efficiency of the combined electrode reactor reached 99.1% without detectable nitrate at an influent NO 2 - -N/NH 4 + -N ratio of 1.5. On day 223, using the model calculations based on reaction equations, 19.7% of total nitrogen was removed via the autotrophic denitrification process, while the majority of nitrogen removal (approximately 79.4%) was attributed to the anammox reaction. Small variations of the population numbers and community structure of artificial bacteria according to electron microscopy predicted that the anammox and autotrophic denitrifying biomasses could coexist in the electrode reactor. Then, 16S rRNA analysis determined that the anammox biomass group was always dominant in mixed flora during continuous cultivation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. The Integrity of Process: Is Inner Transition Sufficient?

    Directory of Open Access Journals (Sweden)

    Clare Power

    2016-05-01

    Full Text Available The Transition movement is based on the notion that peak oil, climate change and the precarious economic situation cause the greatest potential disruptions to human society and therefore require a pre-emptive response. As such its focus is on proactively creating a future in local communities that meets people‘s psychological and physical needs rather than reacting to the crises that seem imminent. This paper draws on research into the Transition movement in the Australian context that considers the role of inner Transition which is one of the features that differentiates Transition from other movements for change. However, inner Transition has tended to be marginalised in the movement, because ultimately, action oriented outcomes take precedence over the often difficult work associated with group dynamics and relational experiences associated with inner Transition, even though they can affect the carriage and outcomes of activities and projects. The privileging of outer over inner Transition and action over process is a reflection of broader society’s grappling with the human dynamics inherent in any process of change. Where such concerns are unproblematised, this raises questions about the extent to which movements replicate existing paradigms and structures or take a prefigurative approach and challenge and re-imagine them in their practice.

  9. Process and data fragmentation-oriented enterprise network integration with collaboration modelling and collaboration agents

    Science.gov (United States)

    Li, Qing; Wang, Ze-yuan; Cao, Zhi-chao; Du, Rui-yang; Luo, Hao

    2015-08-01

    With the process of globalisation and the development of management models and information technology, enterprise cooperation and collaboration has developed from intra-enterprise integration, outsourcing and inter-enterprise integration, and supply chain management, to virtual enterprises and enterprise networks. Some midfielder enterprises begin to serve for different supply chains. Therefore, they combine related supply chains into a complex enterprise network. The main challenges for enterprise network's integration and collaboration are business process and data fragmentation beyond organisational boundaries. This paper reviews the requirements of enterprise network's integration and collaboration, as well as the development of new information technologies. Based on service-oriented architecture (SOA), collaboration modelling and collaboration agents are introduced to solve problems of collaborative management for service convergence under the condition of process and data fragmentation. A model-driven methodology is developed to design and deploy the integrating framework. An industrial experiment is designed and implemented to illustrate the usage of developed technologies in this paper.

  10. Business process integration between European manufacturers and transport and logistics service providers

    DEFF Research Database (Denmark)

    Mortensen, Ole; Lemoine, W

    2005-01-01

    The goal of the Supply Chain Management process is to create value for customers, stakeholders and all supply chain members, through the integration of disparate processes like manufacturing flow management, customer service and order fulfillment. However, many firms fail in the path of achieving...... a total integration. This study illustrates, from an empirical point of view, the problems associated to SC integration among European firms operating in global/international markets. The focus is on the relationship between two echelons in the supply chain: manufacturers and their transport and logistics...... service providers (TLSPs). The paper examines (1) the characteristics of the collaborative partnerships established between manufacturers and their TLSPs; (2) to what extent manufacturers and their TLSPs have integrated SC business processes; (3) the IT used to support the SC cooperation and integration...

  11. Vacuolar processing enzyme: an executor of plant cell death.

    Science.gov (United States)

    Hara-Nishimura, Ikuko; Hatsugai, Noriyuki; Nakaune, Satoru; Kuroyanagi, Miwa; Nishimura, Mikio

    2005-08-01

    Apoptotic cell death in animals is regulated by cysteine proteinases called caspases. Recently, vacuolar processing enzyme (VPE) was identified as a plant caspase. VPE deficiency prevents cell death during hypersensitive response and cell death of limited cell layers at the early stage of embryogenesis. Because plants do not have macrophages, dying cells must degrade their materials by themselves. VPE plays an essential role in the regulation of the lytic system of plants during the processes of defense and development. VPE is localized in the vacuoles, unlike animal caspases, which are localized in the cytosol. Thus, plants might have evolved a regulated cellular suicide strategy that, unlike animal apoptosis, is mediated by VPE and the vacuoles.

  12. The Effect of Information Security Management on Organizational Processes Integration in Supply Chain

    OpenAIRE

    Mohsen Shafiei Nikabadi; Ahmad Jafarian; Azam Jalili Bolhasani

    2012-01-01

    : The major purpose of this article was that how information security management has effect on supply chain integration and the effect of implementing "information security management system" on enhancing supplies chain integration. In this respect, current research was seeking a combination overview to these tow approaches (Information Security Management and Organizational Processes Integration by Enterprise Resources Planning System) and after that determined factors of these two import...

  13. Integrated circuit for processing a low-frequency signal from a seismic detector

    Energy Technology Data Exchange (ETDEWEB)

    Malashevich, N. I.; Roslyakov, A. S.; Polomoshnov, S. A., E-mail: S.Polomoshnov@tsen.ru; Fedorov, R. A. [Research and Production Complex ' Technological Center' of the Moscow Institute of Electronic Technology (Russian Federation)

    2011-12-15

    Specific features for the detection and processing of a low-frequency signal from a seismic detector are considered in terms of an integrated circuit based on a large matrix crystal of the 5507 series. This integrated circuit is designed for the detection of human movements. The specific features of the information signal, obtained at the output of the seismic detector, and the main characteristics of the integrated circuit and its structure are reported.

  14. The use of artificial intelligence techniques to improve the multiple payload integration process

    Science.gov (United States)

    Cutts, Dannie E.; Widgren, Brian K.

    1992-01-01

    A maximum return of science and products with a minimum expenditure of time and resources is a major goal of mission payload integration. A critical component then, in successful mission payload integration is the acquisition and analysis of experiment requirements from the principal investigator and payload element developer teams. One effort to use artificial intelligence techniques to improve the acquisition and analysis of experiment requirements within the payload integration process is described.

  15. Integrating best evidence into patient care: a process facilitated by a seamless integration with informatics tools.

    Science.gov (United States)

    Giuse, Nunzia B; Williams, Annette M; Giuse, Dario A

    2010-07-01

    The Vanderbilt University paper discusses how the Eskind Biomedical Library at Vanderbilt University Medical Center transitioned from a simplistic approach that linked resources to the institutional electronic medical record system, StarPanel, to a value-added service that is designed to deliver highly relevant information. Clinical teams formulate complex patient-specific questions via an evidence-based medicine literature request basket linked to individual patient records. The paper transitions into discussing how the StarPanel approach acted as a springboard for two additional projects that use highly trained knowledge management librarians with informatics expertise to integrate evidence into both order sets and a patient portal, MyHealth@Vanderbilt.

  16. The design, construction, and operation of the Integrated Radwaste Treatment System (IRTS) Drum Cell

    International Nuclear Information System (INIS)

    Landau, B.; Russillo, A.; Frank, D.; Garland, D.

    1989-12-01

    This report describes the design, construction, and the operation of the Integrated Radwaste Treatment Systems (IRTS) Drum Cell at the West Valley Demonstration Project (WVDP), West Valley, New York. The IRTS Drum Cell was designed to provide a shielded, secure storage area for the remote handling and placement of low-level Class C radioactive waste produced in the IRTS. The Drum Cell was designed to contain up to approximately 8,804 drums from decontaminated supernatant processing. This waste is to be poured into 0.27m 3 in a temperature controlled environment to ensure the cement will not be subjected to freezing and thawing cycles. A Temporary Weather Structure (TWS), a pre-engineered building, now encloses the Drum Cell and associated equipment so that remote waste-handling and placement operations can continue without regard to weather conditions. The Drum Cell was designed so that this TWS could be removed and the low-level waste entombed in place. Final disposition of this low-level waste is currently being evaluated in an Environmental Impact Statement (EIS). 10 refs., 11 figs., 1 tab

  17. High-throughput miniaturized bioreactors for cell culture process development: reproducibility, scalability, and control.

    Science.gov (United States)

    Rameez, Shahid; Mostafa, Sigma S; Miller, Christopher; Shukla, Abhinav A

    2014-01-01

    Decreasing the timeframe for cell culture process development has been a key goal toward accelerating biopharmaceutical development. Advanced Microscale Bioreactors (ambr™) is an automated micro-bioreactor system with miniature single-use bioreactors with a 10-15 mL working volume controlled by an automated workstation. This system was compared to conventional bioreactor systems in terms of its performance for the production of a monoclonal antibody in a recombinant Chinese Hamster Ovary cell line. The miniaturized bioreactor system was found to produce cell culture profiles that matched across scales to 3 L, 15 L, and 200 L stirred tank bioreactors. The processes used in this article involve complex feed formulations, perturbations, and strict process control within the design space, which are in-line with processes used for commercial scale manufacturing of biopharmaceuticals. Changes to important process parameters in ambr™ resulted in predictable cell growth, viability and titer changes, which were in good agreement to data from the conventional larger scale bioreactors. ambr™ was found to successfully reproduce variations in temperature, dissolved oxygen (DO), and pH conditions similar to the larger bioreactor systems. Additionally, the miniature bioreactors were found to react well to perturbations in pH and DO through adjustments to the Proportional and Integral control loop. The data presented here demonstrates the utility of the ambr™ system as a high throughput system for cell culture process development. © 2014 American Institute of Chemical Engineers.

  18. Low energy production processes in manufacturing of silicon solar cells

    Science.gov (United States)

    Kirkpatrick, A. R.

    1976-01-01

    Ion implantation and pulsed energy techniques are being combined for fabrication of silicon solar cells totally under vacuum and at room temperature. Simplified sequences allow very short processing times with small process energy consumption. Economic projections for fully automated production are excellent.

  19. Drosophila Sld5 is essential for normal cell cycle progression and maintenance of genomic integrity

    Energy Technology Data Exchange (ETDEWEB)

    Gouge, Catherine A. [Department of Biology, East Carolina University East Carolina University, Greenville, NC 27858 (United States); Christensen, Tim W., E-mail: christensent@ecu.edu [Department of Biology, East Carolina University East Carolina University, Greenville, NC 27858 (United States)

    2010-09-10

    Research highlights: {yields} Drosophila Sld5 interacts with Psf1, PPsf2, and Mcm10. {yields} Haploinsufficiency of Sld5 leads to M-phase delay and genomic instability. {yields} Sld5 is also required for normal S phase progression. -- Abstract: Essential for the normal functioning of a cell is the maintenance of genomic integrity. Failure in this process is often catastrophic for the organism, leading to cell death or mis-proliferation. Central to genomic integrity is the faithful replication of DNA during S phase. The GINS complex has recently come to light as a critical player in DNA replication through stabilization of MCM2-7 and Cdc45 as a member of the CMG complex which is likely responsible for the processivity of helicase activity during S phase. The GINS complex is made up of 4 members in a 1:1:1:1 ratio: Psf1, Psf2, Psf3, And Sld5. Here we present the first analysis of the function of the Sld5 subunit in a multicellular organism. We show that Drosophila Sld5 interacts with Psf1, Psf2, and Mcm10 and that mutations in Sld5 lead to M and S phase delays with chromosomes exhibiting hallmarks of genomic instability.

  20. Improving the Document Development Process: Integrating Relational Data and Statistical Process Control.

    Science.gov (United States)

    Miller, John

    1994-01-01

    Presents an approach to document numbering, document titling, and process measurement which, when used with fundamental techniques of statistical process control, reveals meaningful process-element variation as well as nominal productivity models. (SR)