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Sample records for integrated specificity comment

  1. In search of integrated specificity: comment on Denson, Spanovic, and Miller (2009).

    Science.gov (United States)

    Miller, Gregory E

    2009-11-01

    Psychologists have long been interested in the integrated specificity hypothesis, which maintains that stressors elicit fairly distinct behavioral, emotional, and biological responses that are molded by selective pressures to meet specific demands from the environment. This issue of Psychological Bulletin features a meta-analytic review of the evidence for this proposition by T. F. Denson, M. Spanovic, and N. Miller. Their review concluded that the meta-analytic findings support the "core concept behind the integrated specificity model" (p. 845) and reveal that "within the context of a stressful event, organisms produce an integrated and coordinated response at multiple levels (i.e., cognitive, emotional, physiological)" (p. 845). I argue that conclusions such as this are unwarranted, given the data. Aside from some effects for cortisol, little evidence of specificity was presented, and most of the significant findings reported would be expected by chance alone. I also contend that Denson et al. failed to consider some important sources of evidence bearing on the specificity hypothesis, particularly how appraisals and emotions couple with autonomic nervous system endpoints and functional indices of immune response. If selective pressures did give rise to an integrated stress response, such pathways almost certainly would have been involved. By omitting such outcomes from the meta-analysis, Denson et al. overlooked what are probably the most definitive tests of the specificity hypothesis. As a result, the field is back where it started: with a lot of affection for the concept of integrated specificity but little in the way of definitive evidence to refute or accept it.

  2. Management of comments on DOE's Site Characterization Plan (SCP) and integration with the planned geotechnical program

    International Nuclear Information System (INIS)

    Bjerstedt, T.W.; Gil, A.V.; Baird, F.A.

    1991-01-01

    The US DOE has committed to respond to comments on the SCP throughout the site characterization process. As of January 1990 DOE has received 4,574 comments on both the SCP/Consultation Draft and the statutory SCP. Of these, 2,662 responses have been completed and returned to the originators. Many comments are programmatic in nature and express diverse concerns beyond the scope of the SCP. DOE uses a three-tiered process in responding to comments that integrated technical and management responsibilities. The process defines specific roles in developing, reviewing, and concurring on responses. Commitments or open-items can be generated in DOE responses to comments, which are tracked on a relational database. Major changes reflected in the Secretary of Energy's 1989 reassessment of the high-level waste program were advocated in comments on the SCP. Most DOE commitments, however, deal with consideration of recommendations contained in SCP comments relevant to low-levels of technical planning detail (SCP Study Plans). Commitments are discharged when referred to the appropriate quality-affecting or management process whereupon their merits can be evaluated

  3. In Search of Integrated Specificity: Comment on Denson, Spanovic, and Miller (2009)

    Science.gov (United States)

    Miller, Gregory E.

    2009-01-01

    Psychologists have long been interested in the integrated specificity hypothesis, which maintains that stressors elicit fairly distinct behavioral, emotional, and biological responses that are molded by selective pressures to meet specific demands from the environment. This issue of "Psychological Bulletin" features a meta-analytic review of the…

  4. 78 FR 63170 - Integrated Postsecondary Education Data System (IPEDS) 2013-2016; Extension of Public Comment...

    Science.gov (United States)

    2013-10-23

    ... DEPARTMENT OF EDUCATION Integrated Postsecondary Education Data System (IPEDS) 2013-2016; Extension of Public Comment Period; Correction AGENCY: Department of Education. ACTION: Correction notice... entitled, ``Integrated Postsecondary Education Data System (IPEDS) 2013-2016''. The comment period for this...

  5. Comment on 'Path integral solution for a Mie-type potential'

    International Nuclear Information System (INIS)

    Steiner, F.

    1985-01-01

    We comment on several incorrect results given in a recent paper by Erkoc and Sever (ES). In particular, it is pointed out that their path integral formula for the one-dimensional Mie-Lennard-Jones potential is wrong, since a quantum correction proportional to (h/2π) 2 - which is a consequence of the stochastic nature of the Feynman paths - has been overlooked. The correct expression can be obtained from a general path integral formula, which we have derived in a previous paper. For the particular potential discussed in detail by ES, we give a complete path integral treatment, which allows us to derive the energies and normalized wave functions of the discrete spectrum. (orig.)

  6. 78 FR 16259 - Agency Information Collection Activities; Comment Request; Integrated Postsecondary Education...

    Science.gov (United States)

    2013-03-14

    ... collection system designed to collect basic data from all postsecondary institutions in the United States and...; Comment Request; Integrated Postsecondary Education Data System (IPEDS) 2013-2016 AGENCY: National Center... Postsecondary Education Data System (IPEDS) 2013-2016. OMB Control Number: 1850-0582. Type of Review: Revision...

  7. Integrating the avoided deforestation in a new agreement on climate. Comments on the current debate related to the reduction of emissions induced by deforestation and forest degradation (REDD) in developing countries

    International Nuclear Information System (INIS)

    Wertz-Kanounnikoff, S.; Tubiana, L.

    2007-01-01

    The authors propose some reflections about the current debate related to the reduction of emissions induced by deforestation and forest degradation (REDD) in developing countries. The author comments the two possibilities about one of the issues in this debate: to decide whether this mechanism must be financed by means of mandatory markets or voluntary funds. She also comments the issue on the institutional framework: to integrate REDD implementation in the framework foreseen by Kyoto beyond 2012, or to integrate it in a distinct agreement or protocol. She discusses the variety of national specificities and expectations, and tries to identify perspectives

  8. The Use of Non-Specific Comments in a Conversation Aid for Non-Speaking People.

    Science.gov (United States)

    Todman, John; Morrison, Zara

    1995-01-01

    TALK (Talk Aid using pre-Loaded Knowledge) is a computer system linked to a speech synthesizer which enables nonspeaking people to engage in real-time social conversation. TALK provides categories of general comments that can be used whenever a suitable specific response is unavailable. Results are reported of a study evaluating effectiveness of…

  9. Effective management of regulator RI/FS comments

    International Nuclear Information System (INIS)

    Wolinsky, S.M.; Lojek, D.; George, R.D.; Houser, S.M.; Strimbu, M.J.

    1995-01-01

    This paper describes a successful strategy that facilitates regulatory approval of CERCLA documents required by compliance agreement and CERCLA, based on the experience of Operable Unit 1, Waste Storage Area, of the Fernald Environmental Management Project (FEMP). This strategy, which has become the site standard at the FEMP, was instrumental in obtaining regulator approval of the OU1 RI and FS, and early approval of the Record of Decision during a very tight compliance agreement-driven schedule. This strategy can be applied at any DOE Superfund site, especially where there is need to recover lost schedule, an incentive to meet milestones early, a need to improve the relationship between the DOE and the regulators, or where the regulatory agencies have historically provided a large volume of comments on CERCLA documents. The strategy focuses on early identification and resolution of issues relating to draft RI/FS documents, as raised in regulatory agency review comments. This pro-active strategy has the potential for schedule and cost savings, as well as for improved communication between DOE and the regulators. The strategy includes preparation of a separate comment response document, integration of comment responses with RI/FS documents, development of a database of agency comments and their resolution, and sharing lessons learned with preparers of subsequent RI/FS documents. The paper provides background on the FEMP and describes the FEMP comment response strategy; DOE and regulator interface; the Sitewide Comment Database; networked electronic file management; the process for classifying, analyzing, and responding to comments; integration with base RI/FS documents; and a conclusion

  10. Effective management of regulator RI/FS comments

    Energy Technology Data Exchange (ETDEWEB)

    Wolinsky, S.M.; Lojek, D.; George, R.D.; Houser, S.M.; Strimbu, M.J.

    1995-12-31

    This paper describes a successful strategy that facilitates regulatory approval of CERCLA documents required by compliance agreement and CERCLA, based on the experience of Operable Unit 1, Waste Storage Area, of the Fernald Environmental Management Project (FEMP). This strategy, which has become the site standard at the FEMP, was instrumental in obtaining regulator approval of the OU1 RI and FS, and early approval of the Record of Decision during a very tight compliance agreement-driven schedule. This strategy can be applied at any DOE Superfund site, especially where there is need to recover lost schedule, an incentive to meet milestones early, a need to improve the relationship between the DOE and the regulators, or where the regulatory agencies have historically provided a large volume of comments on CERCLA documents. The strategy focuses on early identification and resolution of issues relating to draft RI/FS documents, as raised in regulatory agency review comments. This pro-active strategy has the potential for schedule and cost savings, as well as for improved communication between DOE and the regulators. The strategy includes preparation of a separate comment response document, integration of comment responses with RI/FS documents, development of a database of agency comments and their resolution, and sharing lessons learned with preparers of subsequent RI/FS documents. The paper provides background on the FEMP and describes the FEMP comment response strategy; DOE and regulator interface; the Sitewide Comment Database; networked electronic file management; the process for classifying, analyzing, and responding to comments; integration with base RI/FS documents; and a conclusion.

  11. Comment on 'Analytical results for a Bessel function times Legendre polynomials class integrals'

    International Nuclear Information System (INIS)

    Cregg, P J; Svedlindh, P

    2007-01-01

    A result is obtained, stemming from Gegenbauer, where the products of certain Bessel functions and exponentials are expressed in terms of an infinite series of spherical Bessel functions and products of associated Legendre functions. Closed form solutions for integrals involving Bessel functions times associated Legendre functions times exponentials, recently elucidated by Neves et al (J. Phys. A: Math. Gen. 39 L293), are then shown to result directly from the orthogonality properties of the associated Legendre functions. This result offers greater flexibility in the treatment of classical Heisenberg chains and may do so in other problems such as occur in electromagnetic diffraction theory. (comment)

  12. Summary of comments received at workshop on use of a Site Specific Advisory Board (SSAB) to facilitate public participation in decommissioning cases

    International Nuclear Information System (INIS)

    Caplin, J.; Padge, G.; Smith, D.; Wiblin, C.

    1995-06-01

    The Nuclear Regulatory Commission (NRC) is conducting an enhanced participatory rulemaking to establish radiological criteria for the decommissioning of NRC-licensed facilities. As part of this rulemaking, On August 20, 1994 the NRC published a proposed rule for public comment. Paragraph 20.1406(b) of the proposed rule would require that the licensee convene a Site Specific Advisory Board (SSAB) if the licensee proposed release of the site for restricted use after decommissioning. To encourage comment the NRC held a workshop on the subject of $SABs on December 6, 7, and 8, 1994. This report summarizes the 567 comments categorized from the transcript of the workshop. The commenters at the workshop generally supported public participation in decommissioning cases. Many participants favored promulgating requirements in the NRC's rules. Some industry participants favored relying on voluntary exchanges between the public and the licensees. Many participants indicated that a SSAB or something functionally equivalent is needed in controversial decommissioning cases, but that some lesser undertaking can achieve meaningful public participation in other cases. No analysis or response to the comments is included in this report

  13. 77 FR 35661 - Proposed Collection; Comment Request

    Science.gov (United States)

    2012-06-14

    ... annual financial statement certified by an independent Certified Public Accountant. No specific form is... extension of a public information collection and seeks public comment on the provisions thereof. Comments... policy for comments and other submissions from members of the public is to make these submissions...

  14. Electrophysiological evidence for speech-specific audiovisual integration

    NARCIS (Netherlands)

    Baart, M.; Stekelenburg, J.J.; Vroomen, J.

    2014-01-01

    Lip-read speech is integrated with heard speech at various neural levels. Here, we investigated the extent to which lip-read induced modulations of the auditory N1 and P2 (measured with EEG) are indicative of speech-specific audiovisual integration, and we explored to what extent the ERPs were

  15. Speech-specificity of two audiovisual integration effects

    DEFF Research Database (Denmark)

    Eskelund, Kasper; Tuomainen, Jyrki; Andersen, Tobias

    2010-01-01

    Seeing the talker’s articulatory mouth movements can influence the auditory speech percept both in speech identification and detection tasks. Here we show that these audiovisual integration effects also occur for sine wave speech (SWS), which is an impoverished speech signal that naïve observers...... often fail to perceive as speech. While audiovisual integration in the identification task only occurred when observers were informed of the speech-like nature of SWS, integration occurred in the detection task both for informed and naïve observers. This shows that both speech-specific and general...... mechanisms underlie audiovisual integration of speech....

  16. Multiloop Integral System Test (MIST): MIST Facility Functional Specification

    International Nuclear Information System (INIS)

    Habib, T.F.; Koksal, C.G.; Moskal, T.E.; Rush, G.C.; Gloudemans, J.R.

    1991-04-01

    The Multiloop Integral System Test (MIST) is part of a multiphase program started in 1983 to address small-break loss-of-coolant accidents (SBLOCAs) specific to Babcock and Wilcox designed plants. MIST is sponsored by the US Nuclear Regulatory Commission, the Babcock ampersand Wilcox Owners Group, the Electric Power Research Institute, and Babcock and Wilcox. The unique features of the Babcock and Wilcox design, specifically the hot leg U-bends and steam generators, prevented the use of existing integral system data or existing integral facilities to address the thermal-hydraulic SBLOCA questions. MIST was specifically designed and constructed for this program, and an existing facility -- the Once Through Integral System (OTIS) -- was also used. Data from MIST and OTIS are used to benchmark the adequacy of system codes, such as RELAP5 and TRAC, for predicting abnormal plant transients. The MIST Functional Specification documents as-built design features, dimensions, instrumentation, and test approach. It also presents the scaling basis for the facility and serves to define the scope of work for the facility design and construction. 13 refs., 112 figs., 38 tabs

  17. 76 FR 14840 - Extension of Comment Period: EPA's Plan for Retrospective Review Under Executive Order 13563

    Science.gov (United States)

    2011-03-18

    .... Integration and Innovation Submit a comment on ``Improving Regulations: Integration and Innovation'' at docket.... Economic Conditions/Market Submit a comment about ``Improving Regulations: Economic Conditions/Market'' at...

  18. Response to Niklasson's comment on Lin, et al. (2012) : "the relation between postural movement and bilateral motor integration".

    Science.gov (United States)

    Lin, Chin-Kai; Kuo, Bor-Chen; Wu, Huey-Min

    2014-10-01

    In the study of Lin, Wu, Lin, Wu, Wu, Kuo, and Yeung (2012 ), the relationship between the validity of postural movement and bilateral motor integration in terms of sensory integration theory was examined. Postural movement is the ability to use the antigravity postures required for stabilization of the neck, trunk and upper extremities via muscle co-contractions in the neck and upper extremities, and balance. Niklasson's (2013 ) comment argued that postural movement should include primitive reflexes in terms of the general abilities approach. Niklasson (2013 ) focused on the efficacy of the treatment rather than the theoretical frameworks implied in the therapeutic activities. For that purpose Lin, et al. (2012 ) used sensory integration as the theoretical foundation, and the relationship between postural movement and bilateral motor integration was assessed via empirical data. The result of Lin, et al. (2012 ) was offered as a theoretical reference for therapeutic activities.

  19. Electrophysiological evidence for speech-specific audiovisual integration.

    Science.gov (United States)

    Baart, Martijn; Stekelenburg, Jeroen J; Vroomen, Jean

    2014-01-01

    Lip-read speech is integrated with heard speech at various neural levels. Here, we investigated the extent to which lip-read induced modulations of the auditory N1 and P2 (measured with EEG) are indicative of speech-specific audiovisual integration, and we explored to what extent the ERPs were modulated by phonetic audiovisual congruency. In order to disentangle speech-specific (phonetic) integration from non-speech integration, we used Sine-Wave Speech (SWS) that was perceived as speech by half of the participants (they were in speech-mode), while the other half was in non-speech mode. Results showed that the N1 obtained with audiovisual stimuli peaked earlier than the N1 evoked by auditory-only stimuli. This lip-read induced speeding up of the N1 occurred for listeners in speech and non-speech mode. In contrast, if listeners were in speech-mode, lip-read speech also modulated the auditory P2, but not if listeners were in non-speech mode, thus revealing speech-specific audiovisual binding. Comparing ERPs for phonetically congruent audiovisual stimuli with ERPs for incongruent stimuli revealed an effect of phonetic stimulus congruency that started at ~200 ms after (in)congruence became apparent. Critically, akin to the P2 suppression, congruency effects were only observed if listeners were in speech mode, and not if they were in non-speech mode. Using identical stimuli, we thus confirm that audiovisual binding involves (partially) different neural mechanisms for sound processing in speech and non-speech mode. © 2013 Published by Elsevier Ltd.

  20. Integrated flight/propulsion control - Subsystem specifications for performance

    Science.gov (United States)

    Neighbors, W. K.; Rock, Stephen M.

    1993-01-01

    A procedure is presented for calculating multiple subsystem specifications given a number of performance requirements on the integrated system. This procedure applies to problems where the control design must be performed in a partitioned manner. It is based on a structured singular value analysis, and generates specifications as magnitude bounds on subsystem uncertainties. The performance requirements should be provided in the form of bounds on transfer functions of the integrated system. This form allows the expression of model following, command tracking, and disturbance rejection requirements. The procedure is demonstrated on a STOVL aircraft design.

  1. System specification for the integrated monitoring and surveillance system

    International Nuclear Information System (INIS)

    1997-09-01

    This System Specification establishes the requirements for the Plutonium Focus Area (PFA) Integrated Monitoring and Surveillance System (IMSS). In this document, ''Integrated Monitoring and Surveillance System'' is used to describe the concept of integrated sensors, computers, personnel, and systems that perform the functions of sensing conditions, acquiring data, monitoring environmental safety and health, controlling and accounting for materials, monitoring material stability, monitoring container integrity, transferring data, and analyzing, reporting, and storing data. This concept encompasses systems (e.g. sensors, personnel, databases, etc.) that are already in place at the sites but may require modifications or additions to meet all identified surveillance requirements. The purpose of this System Specification is to provide Department of Energy (DOE) sites that store plutonium materials with a consolidation of all known requirements for the storage and surveillance of 3013 packages of stabilized plutonium metals and oxides. This compilation may be used (1) as a baseline for surveillance system design specifications where 3013 packages of stabilized plutonium metals and oxides will be stored and monitored; (2) as a checklist for evaluating existing surveillance systems to ensure that all requirements are met for the storage and surveillance of 3013 packages of stabilized plutonium metals and oxides; and (3) as a baseline for preparing procurement specifications tailored for site specific storage and surveillance of 3013 packages of stabilized plutonium metals and oxides

  2. An Integrated Framework to Specify Domain-Specific Modeling Languages

    DEFF Research Database (Denmark)

    Zarrin, Bahram; Baumeister, Hubert

    2018-01-01

    , a logic-based specification language. The drawback of MS DSL Tools is it does not provide a formal and rigorous approach for semantics specifications. In this framework, we use Microsoft DSL Tools to define the metamodel and graphical notations of DSLs, and an extended version of ForSpec as a formal......In this paper, we propose an integrated framework that can be used by DSL designers to implement their desired graphical domain-specific languages. This framework relies on Microsoft DSL Tools, a meta-modeling framework to build graphical domain-specific languages, and an extension of ForSpec...... language to define their semantics. Integrating these technologies under the umbrella of Microsoft Visual Studio IDE allows DSL designers to utilize a single development environment for developing their desired domain-specific languages....

  3. USER SPECIFICATIONS FOR PRESSURE VESSELS AND TECHNICAL INTEGRITY

    Directory of Open Access Journals (Sweden)

    K.S. Johnston

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: Specifications translated from user requirements are prescribed in an attempt to capture and incorporate best practices with regards to the design, fabrication, testing, and operation of pressure vessels. The question as to whether these requirements affect the technical integrity of pressure vessels is often a subjective matter. This paper examines typical user requirement specifications against technical integrity of pressure vessels.
    The paper draws on a survey of a convenience sample of practising engineers in a diversified petrochemical company. When compared with failures on selected pressure vessels recorded by Phillips and Warwick, the respondent feedback confirms the user specifications that have the highest impact on technical integrity.

    AFRIKAANSE OPSOMMING: Gebruikersbehoeftes word saamgevat in spesifikasies wat lei tot goeie praktyk vir ontwerp, vervaarding, toetsing en bedryf van drukvate. Subjektiwiteit van die gebruikersbehoeftes mag soms die tegniese integriteit van ‘n drukvat beinvloed.
    Die navorsing maak by wyse van monsterneming gebruik van die kennis van ingenieurs wat werk in ‘n gediversifiseerde petrochemiese bedryf. Die terugvoering bevestig dat bogenoemde spesifikasies inderdaad die grootste invloed het op tegniese integriteit.

  4. Comments on management of radioactive wastes

    International Nuclear Information System (INIS)

    Kindness, T.N.

    1978-01-01

    A few comments are made concerning the recognized need for a management of radioactive wastes. The comment is made that perhaps a lack of a set of specific understandable goals is why the need hasn't been met. An outline is included that the author feels would lead to a filling of the need

  5. IRIS Toxicological Review of Tert-Butyl Alcohol (Tert-Butanol) (Public Comment Draft)

    Science.gov (United States)

    EPA is developing an Integrated Risk Information System (IRIS) assessment of tert-butyl Alcohol (tert-butanol) and has released the public comment draft assessment for public comment and external peer review. When final, the assessment will appear on the IRIS databa...

  6. Life sciences payload definition and integration study, task C and D. Volume 4: Preliminary equipment item specification catalog

    Science.gov (United States)

    1973-01-01

    A specification catalog to define the equipment to be used for conducting life sciences experiments in a space laboratory is presented. The specification sheets list the purpose of the equipment item, and any specific technical requirements which can be identified. The status of similar hardware for ground use is stated with comments regarding modifications required to achieve spaceflight qualified hardware. Pertinent sketches, commercial catalog sheets, or drawings of the applicable equipment are included.

  7. Selective pressures to maintain attachment site specificity of integrative and conjugative elements.

    Directory of Open Access Journals (Sweden)

    Kayla L Menard

    Full Text Available Integrative and conjugative elements (ICEs are widespread mobile genetic elements that are usually found integrated in bacterial chromosomes. They are important agents of evolution and contribute to the acquisition of new traits, including antibiotic resistances. ICEs can excise from the chromosome and transfer to recipients by conjugation. Many ICEs are site-specific in that they integrate preferentially into a primary attachment site in the bacterial genome. Site-specific ICEs can also integrate into secondary locations, particularly if the primary site is absent. However, little is known about the consequences of integration of ICEs into alternative attachment sites or what drives the apparent maintenance and prevalence of the many ICEs that use a single attachment site. Using ICEBs1, a site-specific ICE from Bacillus subtilis that integrates into a tRNA gene, we found that integration into secondary sites was detrimental to both ICEBs1 and the host cell. Excision of ICEBs1 from secondary sites was impaired either partially or completely, limiting the spread of ICEBs1. Furthermore, induction of ICEBs1 gene expression caused a substantial drop in proliferation and cell viability within three hours. This drop was dependent on rolling circle replication of ICEBs1 that was unable to excise from the chromosome. Together, these detrimental effects provide selective pressure against the survival and dissemination of ICEs that have integrated into alternative sites and may explain the maintenance of site-specific integration for many ICEs.

  8. Discussion of comments from a peer review of a technique for human event analysis (ATHEANA)

    International Nuclear Information System (INIS)

    Forester, J.A.; Ramey-Smith, A.; Bley, D.C.; Kolaczkowski, A.M.; Cooper, S.E.; Wreathall, J.

    1998-01-01

    In May of 1998, a technical basis and implementation guidelines document for A Technique for Human Event Analysis (ATHEANA) was issued as a draft report for public comment (NUREG-1624). In conjunction with the release of the draft NUREG, a paper review of the method, its documentation, and the results of an initial test of the method was held over a two-day period in Seattle, Washington, in June of 1998. Four internationally-known and respected experts in human reliability analysis (HRA) were selected to serve as the peer reviewers and were paid for their services. In addition, approximately 20 other individuals with an interest in HRA and ATHEANA also attended the peer review meeting and were invited to provide comments. The peer review team was asked to comment on any aspect of the method or the report in which improvements could be made and to discuss its strengths and weaknesses. All of the reviewers thought the ATEANA method had made significant contributions to the field of PRA/HRA, in particular by addressing the most important open questions and issues in HRA, by attempting to develop an integrated approach, and by developing a framework capable of identifying types of unsafe actions that generally have not been considered using existing methods. The reviewers had many concerns about specific aspects of the methodology and made many recommendations for ways to improve and extend the method, and to make its application more cost effective and useful to PRA in general. Details of the reviewers' comments and the ATHEANA team's responses to specific criticisms will be discussed

  9. Specific and Complete Local Integration of Patterns in Bayesian Networks

    Directory of Open Access Journals (Sweden)

    Martin Biehl

    2017-05-01

    Full Text Available We present a first formal analysis of specific and complete local integration. Complete local integration was previously proposed as a criterion for detecting entities or wholes in distributed dynamical systems. Such entities in turn were conceived to form the basis of a theory of emergence of agents within dynamical systems. Here, we give a more thorough account of the underlying formal measures. The main contribution is the disintegration theorem which reveals a special role of completely locally integrated patterns (what we call ι-entities within the trajectories they occur in. Apart from proving this theorem we introduce the disintegration hierarchy and its refinement-free version as a way to structure the patterns in a trajectory. Furthermore, we construct the least upper bound and provide a candidate for the greatest lower bound of specific local integration. Finally, we calculate the ι -entities in small example systems as a first sanity check and find that ι -entities largely fulfil simple expectations.

  10. RD53A Integrated Circuit Specifications

    OpenAIRE

    Garcia-Sciveres, Mauricio

    2015-01-01

    Specifications for the RD53 collaboration’s first engineering wafer run of an integrated circuit (IC) for hybrid pixel detector readout, called RD53A. RD53A is intended to demonstrate in a large format IC the suitability of the technology (including radiation tolerance), the stable low threshold operation, and the high hit and trigger rate capabilities, required for HL-LHC upgrades of ATLAS and CMS. The wafer scale production will permit the experiments to prototype bump bonding assembly with...

  11. Interpretative commenting.

    Science.gov (United States)

    Vasikaran, Samuel

    2008-08-01

    * Clinical laboratories should be able to offer interpretation of the results they produce. * At a minimum, contact details for interpretative advice should be available on laboratory reports.Interpretative comments may be verbal or written and printed. * Printed comments on reports should be offered judiciously, only where they would add value; no comment preferred to inappropriate or dangerous comment. * Interpretation should be based on locally agreed or nationally recognised clinical guidelines where available. * Standard tied comments ("canned" comments) can have some limited use.Individualised narrative comments may be particularly useful in the case of tests that are new, complex or unfamiliar to the requesting clinicians and where clinical details are available. * Interpretative commenting should only be provided by appropriately trained and credentialed personnel. * Audit of comments and continued professional development of personnel providing them are important for quality assurance.

  12. Final environmental impact statement: US Spent Fuel Policy. Comment letters on draft statements and major comments with DOE responses

    International Nuclear Information System (INIS)

    1980-05-01

    Notice of availability of the draft environmental impact statement for storage of US spent power reactor fuel was published by DOE in the Federal Register on September 6, 1978. A subsequent notice was published in the Federal Register on December 14, 1978, on the availability of the draft EISs on storage of foreign fuel, on charge for spent fuel storage, and a supplement to the draft EIS on storage of US fuel. Copies of the draft EISs were distributed for review and comment by appropriate Federal agencies, state governments, and other organizations and individuals who were known to have an interest in spent fuel storage activities and those who requested them. Comments and views concerning the draft EISs were requested from other interested agencies, organizations, and individuals by means of the Federal Register notices. Approximately 1600 copies each of the draft Domestic, Foreign, and Charge EISs were distributed for comment. The closing date for comments to be received on the draft EISs was February 15, 1979. Copies of the EISs (upon publication) and comment letters received were placed for public inspection in DOE public document rooms at 10 locations throughout the country. To the extent practicable, comments received after the closing date were also considered in the preparation of the final EIS. A total of 78 comment letters (some with supplements) were received. These comment letters are reproduced in their entirety in Section I of this volume. Approximately 600 specific comments were identified in these letters

  13. Comment on 'Integral cross sections for electron impact excitation of electronic states of N2'

    International Nuclear Information System (INIS)

    Cenian, A; Chernukho, A; Bogaerts, A; Gijbels, R

    2002-01-01

    Based on the existing experimental data and their statistical errors, it is not possible to make a sound recommendation of the cross-section set of Campbell et al (J. Phys. B: At. Mol. Opt. Phys. 34 (2001) 1185). We comment on this paper. (comment)

  14. Integrated safety assessment report: Integrated Safety Assessment Program: Millstone Nuclear Power Station, Unit 1 (Docket No. 50-245): Draft report

    International Nuclear Information System (INIS)

    1987-04-01

    The Integrated Safety Assessment Program (ISAP) was initiated in November 1984, by the US Nuclear Regulatory Commission to conduct integrated assessments for operating nuclear power reactors. The integrated assessment is conducted in a plant-specific basis to evaluate all licensing actions, licensee initiated plant improvements and selected unresolved generic/safety issues to establish implementation schedules for each item. In addition, procedures will be established to allow for a periodic updating of the schedules to account for licensing issues that arise in the future. This report documents the review of Millstone Nuclear Power Station, Unit No. 1, operated by Northeast Nuclear Energy Company (located in Waterford, Connecticut). Millstone Nuclear Power Station, Unit No. 1, is one of two plants being reviewed under the pilot program for ISAP. This report indicates how 85 topics selected for review were addressed. This report presents the staff's recommendations regarding the corrective actions to resolve the 85 topics and other actions to enhance plant safety. The report is being issued in draft form to obtain comments from the licensee, nuclear safety experts, and the Advisory Committee for Reactor Safeguards (ACRS). Once those comments have been resolved, the staff will present its positions, along with a long-term implementation schedule from the licensee, in the final version of this report

  15. 77 FR 35753 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-06-14

    ..., Public Law 104-13, on or after the date of publication of this notice. DATES: Comments should be received on or before July 16, 2012 to be assured of consideration. ADDRESSES: Send comments regarding the...-Contract Award Information. Abstract: Information requested of contractors is specific to each contract and...

  16. EPA scientific integrity policy draft

    Science.gov (United States)

    Showstack, Randy

    2011-08-01

    The U.S. Environmental Protection Agency (EPA) issued its draft scientific integrity policy on 5 August. The draft policy addresses scientific ethical standards, communications with the public, the use of advisory committees and peer review, and professional development. The draft policy was developed by an ad hoc group of EPA senior staff and scientists in response to a December 2010 memorandum on scientific integrity from the White House Office of Science and Technology Policy. The agency is accepting public comments on the draft through 6 September; comments should be sent to osa.staff@epa.gov. For more information, see http://www.epa.gov/stpc/pdfs/draft-scientific-integrity-policy-aug2011.pdf.

  17. Competencies "plus": the nature of written comments on internal medicine residents' evaluation forms.

    Science.gov (United States)

    Ginsburg, Shiphra; Gold, Wayne; Cavalcanti, Rodrigo B; Kurabi, Bochra; McDonald-Blumer, Heather

    2011-10-01

    Comments on residents' in-training evaluation reports (ITERs) may be more useful than scores in identifying trainees in difficulty. However, little is known about the nature of comments written by internal medicine faculty on residents' ITERs. Comments on 1,770 ITERs (from 180 residents in postgraduate years 1-3) were analyzed using constructivist grounded theory beginning with an existing framework. Ninety-three percent of ITERs contained comments, which were frequently easy to map onto traditional competencies, such as knowledge base (n = 1,075 comments) to the CanMEDs Medical Expert role. Many comments, however, could be linked to several overlapping competencies. Also common were comments completely unrelated to competencies, for instance, the resident's impact on staff (813), or personality issues (450). Residents' "trajectory" was a major theme (performance in relation to expected norms [494], improvement seen [286], or future predictions [286]). Faculty's assessments of residents are underpinned by factors related and unrelated to traditional competencies. Future evaluations should attempt to capture these holistic, integrated impressions.

  18. 78 FR 59086 - Proposed Agency Information Collection Activities; Comment Request

    Science.gov (United States)

    2013-09-25

    ... extension while it is determining the proper course of action to take to ensure that certain unattended... transporting hazardous materials, are properly secured against unintended movement. Before submitting these... soliciting public comment on specific aspects of the activities identified below. DATES: Comments must be...

  19. Public comments and responses to the 1989 Hanford cleanup five-year plan

    International Nuclear Information System (INIS)

    1991-06-01

    In April 1990 the US Department of Energy (DOE) issued a site- specific Five-Year Plan (DOE-RL 1989a) on Hanford's cleanup for public review and comment. The plan guides Hanford in carrying out DOE's national plan for environmental restoration and waste management. During the 90-day public comment period, DOE held nine public meetings to answer questions and gather comments on the plan. This report is in three main sections. The first presents consolidated public comments and responses. These were compiled from both verbal comments from public meetings and written comments. The second section contains comments not responded to in this plan. Those comments were outside this plan's scope, related to how we gathered public comments, or intended for and directed to DOE-Headquarters. In the appendixes are the written comment letters we received and a short glossary and list of special terms we use. The source of comments is shown in parentheses after the comment. The individual who made the comment, the city of the public meeting, or the organization name is generally used. When several sources gave the same comment, a source was not listed. 26 refs

  20. 78 FR 2960 - Request for Comments on Preparation of Patent Applications

    Science.gov (United States)

    2013-01-15

    ... seeking public comment on advantages and disadvantages of applicants employing the following practices... comments on advantages and disadvantages of applicants employing the following practices when preparing... the specification and/or claims, particularly for inventions related to certain technologies, such as...

  1. A comment on the infra-red problem in the AdS/CFT correspondence

    International Nuclear Information System (INIS)

    Gottschalk, Hanno; Thaler, Horst

    2008-01-01

    In this note we report on some recent progress in proving the AdS/CFT correspondence for quantum fields using rigorously defined Euclidean path integrals. We also comment on the infra-red problem in the AdS/CFT correspondence and argue that it is different from the usual IR problem in constructive quantum field theory. To illustrate this, a triviality proof based on hypercontractivity estimates is given for the case of an ultraviolet regularized potential of type: φ 4 :. We also give a brief discussion on possible renormalization strategies and the specific problems that arise in this context. (orig.)

  2. A comment on the infra-red problem in the AdS/CFT correspondence

    Energy Technology Data Exchange (ETDEWEB)

    Gottschalk, Hanno; Thaler, Horst

    2008-03-15

    In this note we report on some recent progress in proving the AdS/CFT correspondence for quantum fields using rigorously defined Euclidean path integrals. We also comment on the infra-red problem in the AdS/CFT correspondence and argue that it is different from the usual IR problem in constructive quantum field theory. To illustrate this, a triviality proof based on hypercontractivity estimates is given for the case of an ultraviolet regularized potential of type: {phi}{sup 4}:. We also give a brief discussion on possible renormalization strategies and the specific problems that arise in this context. (orig.)

  3. 76 FR 50726 - Integrated System Power Rates: Correction

    Science.gov (United States)

    2011-08-16

    ... DEPARTMENT OF ENERGY Southwestern Power Administration Integrated System Power Rates: Correction AGENCY: Southwestern Power Administration, DOE. ACTION: Notice of public review and comment; Correction... date listed for the combined Public Information and Comment Forum (Forum) was erroneously listed in the...

  4. 77 FR 20478 - Proposed Agency Information Collection Activities; Comment Request

    Science.gov (United States)

    2012-04-04

    ... soliciting public comment on specific aspects of the activities identified below. DATES: Comments must be... an accident or incident arising from the failure of a signal appliance, device, method, or [[Page... favorable aspect than intended or other condition hazardous to the movement of a train. Section 233.7 sets...

  5. System specification/system design document comment review: Plutonium Stabilization and Packaging System. Notes of conference

    International Nuclear Information System (INIS)

    1996-01-01

    A meeting was held between DOE personnel and the BNFL team to review the proposed resolutions to DOE comments on the initial issue of the system specification and system design document for the Plutonium Stabilization and Packaging System. The objectives of this project are to design, fabricate, install, and start up a glovebox system for the safe repackaging of plutonium oxide and metal, with a requirement of a 50-year storage period. The areas discussed at the meeting were: nitrogen in can; moisture instrumentation; glovebox atmosphere; can marking bar coding; weld quality; NFPA-101 references; inner can swabbing; ultimate storage environment; throughput; convenience can screw-top design; furnacetrays; authorization basis; compactor safety; schedule for DOE review actions; fire protection; criticality safety; applicable standards; approach to MC and A; homogeneous oxide; resistance welder power; and tray overfill. Revised resolutions were drafted and are presented

  6. Analysis of public comments on the proposed rule on nuclear power plant license renewal

    International Nuclear Information System (INIS)

    1991-12-01

    This report provides a summary and analysis of public comments on the proposed license renewal rule for the nuclear power plants (10 CFR Part 54) published in the Federal Register on 17 July 1990. It also documents the NRC's resolution of the issues raised by the commenters. Comments from 121 organizations and 76 individuals were reviewed and analyzed to identify the issues, including those pertaining to the adequacy of the licensing basis, the performance of an integrated plant assessment, backfit considerations, and need for public hearings. The analysis included grouping of commenters' views according to the issues raised. The public comments analyzed in this report were taken into consideration in the development of the final rule and revisions to the supporting documents

  7. 78 FR 12042 - Electric Grid Integration Technical Workshops

    Science.gov (United States)

    2013-02-21

    ... DEPARTMENT OF ENERGY Electric Grid Integration Technical Workshops AGENCY: Grid Tech Team, U.S. Department of Energy. ACTION: Notice of availability; request for comments. SUMMARY: Notice is hereby given that two documents are publicly available and the Department of Energy is requesting public comments...

  8. Comment response document for the Secretary of Energy's ''Report to Congress on Reassessment of the Civilian Radioactive Waste Management Program''

    International Nuclear Information System (INIS)

    1990-11-01

    On November 29, 1989, the Secretary of Energy published his ''Report to Congress on the Reassessment of the Civilian Radioactive Waste Management Program'' (Report), and sent copies to numerous interested parties for their review and comment. This document summarizes comments received on the Report and presents the DOE's current responses to those comments as a basis for further discussions. Included as appendixes are a list of commenters, a crosswalk showing where each comment is addressed, the comment letters themselves with specific comments delineated, and the DOE's response to those letters. Twenty-five individuals or organizations submitted comments on the Report. The DOE identified 130 individual comments and classified them into the following seven categories: Management, Institutional, Regulatory, Transportation, Monitored Retrievable Storage, Scheduling, and Yucca Mountain. For the responses, comments were than grouped into more specific topics under each of the major headings. The DOE attempted to respond to all comments

  9. Prespacer processing and specific integration in a Type I-A CRISPR system

    Science.gov (United States)

    Rollie, Clare; Graham, Shirley; Rouillon, Christophe

    2018-01-01

    Abstract The CRISPR–Cas system for prokaryotic adaptive immunity provides RNA-mediated protection from viruses and mobile genetic elements. Adaptation is dependent on the Cas1 and Cas2 proteins along with varying accessory proteins. Here we analyse the process in Sulfolobus solfataricus, showing that while Cas1 and Cas2 catalyze spacer integration in vitro, host factors are required for specificity. Specific integration also requires at least 400 bp of the leader sequence, and is dependent on the presence of hydrolysable ATP, suggestive of an active process that may involve DNA remodelling. Specific spacer integration is associated with processing of prespacer 3′ ends in a PAM-dependent manner. This is reflected in PAM-dependent processing of prespacer 3′ ends in vitro in the presence of cell lysate or the Cas4 nuclease, in a reaction consistent with PAM-directed binding and protection of prespacer DNA. These results highlight the diverse interplay between CRISPR–Cas elements and host proteins across CRISPR types. PMID:29228332

  10. Towards a synergy framework across neuroscience and robotics: Lessons learned and open questions. Reply to comments on: "Hand synergies: Integration of robotics and neuroscience for understanding the control of biological and artificial hands"

    Science.gov (United States)

    Santello, Marco; Bianchi, Matteo; Gabiccini, Marco; Ricciardi, Emiliano; Salvietti, Gionata; Prattichizzo, Domenico; Ernst, Marc; Moscatelli, Alessandro; Jorntell, Henrik; Kappers, Astrid M. L.; Kyriakopoulos, Kostas; Schaeffer, Alin Abu; Castellini, Claudio; Bicchi, Antonio

    2016-07-01

    We would like to thank all commentators for their insightful commentaries. Thanks to their diverse and complementary expertise in neuroscience and robotics, the commentators have provided us with the opportunity to further discuss state-of-the-art and gaps in the integration of neuroscience and robotics reviewed in our article. We organized our reply in two sections that capture the main points of all commentaries [1-9]: (1) Advantages and limitations of the synergy approach in neuroscience and robotics, and (2) Learning and role of sensory feedback in biological and robotics synergies.

  11. Comments on `A discrete optimal control problem for descriptor systems'

    DEFF Research Database (Denmark)

    Ravn, Hans

    1990-01-01

    In the above-mentioned work (see ibid., vol.34, p.177-81 (1989)), necessary and sufficient optimality conditions are derived for a discrete-time optimal problem, as well as other specific cases of implicit and explicit dynamic systems. The commenter corrects a mistake and demonstrates that there ......In the above-mentioned work (see ibid., vol.34, p.177-81 (1989)), necessary and sufficient optimality conditions are derived for a discrete-time optimal problem, as well as other specific cases of implicit and explicit dynamic systems. The commenter corrects a mistake and demonstrates...

  12. Comments on the NRC Safety Research Program Budget for Fiscal Years 1984 and 1985

    International Nuclear Information System (INIS)

    1982-07-01

    The comments are divided into three parts. Section 2 relates generally to programs for which greater effort or emphasis is needed. Section 3 provides specific comments on the proposed programs in each Decision Unit and, in most cases, for individual Subelements within each Decision Unit. Specific recommendations regarding the Research Program Support Budget are given in Section 4

  13. Sound specificity effects in spoken word recognition: The effect of integrality between words and sounds.

    Science.gov (United States)

    Strori, Dorina; Zaar, Johannes; Cooke, Martin; Mattys, Sven L

    2018-01-01

    Recent evidence has shown that nonlinguistic sounds co-occurring with spoken words may be retained in memory and affect later retrieval of the words. This sound-specificity effect shares many characteristics with the classic voice-specificity effect. In this study, we argue that the sound-specificity effect is conditional upon the context in which the word and sound coexist. Specifically, we argue that, besides co-occurrence, integrality between words and sounds is a crucial factor in the emergence of the effect. In two recognition-memory experiments, we compared the emergence of voice and sound specificity effects. In Experiment 1 , we examined two conditions where integrality is high. Namely, the classic voice-specificity effect (Exp. 1a) was compared with a condition in which the intensity envelope of a background sound was modulated along the intensity envelope of the accompanying spoken word (Exp. 1b). Results revealed a robust voice-specificity effect and, critically, a comparable sound-specificity effect: A change in the paired sound from exposure to test led to a decrease in word-recognition performance. In the second experiment, we sought to disentangle the contribution of integrality from a mere co-occurrence context effect by removing the intensity modulation. The absence of integrality led to the disappearance of the sound-specificity effect. Taken together, the results suggest that the assimilation of background sounds into memory cannot be reduced to a simple context effect. Rather, it is conditioned by the extent to which words and sounds are perceived as integral as opposed to distinct auditory objects.

  14. 75 FR 27346 - Agency Information Collection Request. 30-Day Public Comment Request

    Science.gov (United States)

    2010-05-14

    ... of a proposed collection for public comment. Interested persons are invited to send comments... plans, employers, and health care providers. We know very little about why consumers, and specifically... the newer, more robust Internet-based tools for tracking their health and health care services. This...

  15. 75 FR 7268 - Agency Information Collection Request; 60-Day Public Comment Request

    Science.gov (United States)

    2010-02-18

    ... information collection request for public comment. Interested persons are invited to send comments regarding... plans, employers, and health care providers. We know very little about why consumers, and specifically... the newer, more robust Internet-based tools for tracking their health and health care services. This...

  16. RD53A Integrated Circuit Specifications

    CERN Document Server

    Garcia-Sciveres, Mauricio

    2015-01-01

    Specifications for the RD53 collaboration’s first engineering wafer run of an integrated circuit (IC) for hybrid pixel detector readout, called RD53A. RD53A is intended to demonstrate in a large format IC the suitability of the technology (including radiation tolerance), the stable low threshold operation, and the high hit and trigger rate capabilities, required for HL-LHC upgrades of ATLAS and CMS. The wafer scale production will permit the experiments to prototype bump bonding assembly with realistic sensors in this new technology and to measure the performance of hybrid assemblies. RD53A is not intended to be a final production IC for use in an experiment, and will contain design variations for testing purposes, making the pixel matrix non-uniform.

  17. 77 FR 47835 - Agency Information Collection Activities; Proposed Collection; Comment Request; Consolidated...

    Science.gov (United States)

    2012-08-10

    ... Number 2050-0096 (National Oil and Hazardous Substance Pollution Contingency Plan (NCP)). The first ICR... or view public comments, access the index listing of the contents of the docket, and to access those... comments: 1. Explain your views as clearly as possible and provide specific examples. 2. Describe any...

  18. 78 FR 18576 - Agency Information Collection Activities; Comment Request; Experimental Sites Data Collection...

    Science.gov (United States)

    2013-03-27

    ... and provide the requested data in the desired format. ED is soliciting comments on the proposed... specific information/performance data for analysis of the experiments. This effort will assist the...; Comment Request; Experimental Sites Data Collection Instrument AGENCY: Department of Education (ED...

  19. State of Nevada comments on the US Department of Energy consultation draft site characterization plan, Yucca Mountain site, Nevada research and development area, Nevada

    International Nuclear Information System (INIS)

    1988-09-01

    The comments presented here represent a review effort by the Nevada Agency for Nuclear Projects and its Technical Support Contractors and advisors. Part I presents an overview of the comments contained in the document. The overview takes the form of general concerns and comments organized by specific areas of concern. The overview does not follow the format of the CD-SCP. Part II contains specific comments of the Nevada Agency for Nuclear Projects. These comments respond to specifics of the CD-SCP and do so in relation to the organizational format employed in the CD-SCP. Because of the way it is organized, the CD-SCP encouraged a certain degree of redundancy in our response. Part III of this document contains verbatim comments received from the Agency's Technical Contractors and advisors. These comments address issues and contain information not contained in Parts I and II. As such, these comments should be viewed as important in their own right -- not as appendices to the State's comment document

  20. Geographic specificity and positionality of public input in transportation: a rural transportation planning case from Central Texas

    Directory of Open Access Journals (Sweden)

    Greg P. Griffin

    2014-01-01

    Full Text Available Current transportation planning processes often incorporate public input, but the types of engagement techniques can affect the ability of practitioners to meaningfully include local ideas. This study incorporates literature integrating communicative rationality with participatory mapping, supported by a case study focusing on two public engagement techniques. A transportation planning process in Central Texas is evaluated in terms of the geographic specificity and positionality of comments received from open-ended responses on a questionnaire and a facilitated mapping session, and reviews this input for relevance to developing a transportation plan. Although all input received from the public can be valuable in the process, location-based comments may be more actionable by transportation planners. Participants’ perceived roles likely affect their level of engagement, which planners can facilitate to maximize the quality of involvement. Planners are advised to understand the positionality of project stakeholders and professionals, designing involvement methods considering geographic specificity appropriate for each project.

  1. 77 FR 42764 - Certain Integrated Circuits, Chipsets, & Products Containing Same Including Televisions; Notice...

    Science.gov (United States)

    2012-07-20

    ...Notice is hereby given that the presiding administrative law judge has issued a Final Initial Determination and Recommended Determination on Remedy and Bonding in the above-captioned investigation. The Commission is soliciting comments on public interest issues raised by the recommended relief, specifically a limited exclusion order against certain integrated circuits, chipsets, and products containing the same including televisions, imported by respondents MediaTek Inc. of Hsinchu City, Taiwan and Zoran Corporation of Sunnyvale, California.

  2. Public comments and responses to the 1993 Hanford cleanup five-year plan

    International Nuclear Information System (INIS)

    1993-08-01

    In March 1993, the US Department of Energy, Richland Operations Office (DOE-RL) published its annual Site-Specific Five-Year Plan. The Site-Specific Plan is published to inform the public about the background, status, and plans for Environmental Restoration (ER) and Waste Management (WM) activities at the Hanford site. It is the only document that seeks to bring all ER and WM elements together in one document. The Site-Specific Plan is a companion document to the National Five-Year Plan that deals with all the sites within the DOE complex on a summary level. This Response to Comments document does not try to address every question or concern raised during the public comment period. Some questions were outside the scope of the Five-Year Plan, some we could not decipher, others were variations of the same question. The initial round of public meetings was held in Portland, Oregon, and Seattle, Pasco, and Olympia, Washington. At the request of the Oregon Department of Energy (ODOE) and the Washington State Department of Ecology (Ecology), a second round of meetings was held in Portland and Olympia. Both agencies felt that the first two meetings were held with too little advance notice, and before the Plan could be distributed. Once the public meetings were over and the comment period closed, we then compiled the public comments, largely from audio tapes of the meetings. Individual functions within Hanford were asked to consider and respond to the comments

  3. Public comments and responses to the 1991 Hanford Cleanup Five-Year Plan

    International Nuclear Information System (INIS)

    1992-05-01

    The Department of Energy (DOE) Richland Field Office (RL) updated its Site-Specific Plan (DOE-RL 1991a) dealing with cleanup and operation of the Hanford Site in September 1991. The plan provides direction as to how DOE will carry out the national strategy for managing and cleaning up the Hanford Site wastes resulting from production of nuclear weapons. The plan is updated annually. We asked the public to comment on the plan during its 60-day public comment period. This report presents the comments and provides responses. The introduction explains how the comments were gathered and how we responded. This report is in four main sections: (1) comments and responses addressed locally; (2) comments forwarded to DOE-Headquarters for their response (these responses will appear in the National Five-Year Plan [DOE 1991a]); (3) comments we did not respond to here because they were outside the scope, or about how we gathered the public's comments; and (4) the appendices, which include a glossary, a list of acronyms used in the document, and the letters and cards we received reproduced in their entirety

  4. Comment

    DEFF Research Database (Denmark)

    Sørensen, Peter Birch

    1999-01-01

    Comment on: Alessandra Casella (1999) Tradable deficit permits: efficient implementation of the Stability Pact in the European Monetary Union. Economic Policy 14 (29), 321-362......Comment on: Alessandra Casella (1999) Tradable deficit permits: efficient implementation of the Stability Pact in the European Monetary Union. Economic Policy 14 (29), 321-362...

  5. 76 FR 50188 - Notice of Proposed Methodology for the Delaware River and Bay Integrated List Water Quality...

    Science.gov (United States)

    2011-08-12

    ... Integrated List Water Quality Assessment AGENCY: Delaware River Basin Commission. ACTION: Notice. SUMMARY... Integrated List Water Quality Assessment is available for review and comment. DATES: Comments must be... should have the phrase ``Water Quality Assessment 2012'' in the subject line and should include the name...

  6. Comment

    DEFF Research Database (Denmark)

    Sørensen, Peter Birch

    1999-01-01

    Comment on: Besley and Seabright (1999) The effects and policy implications of state aid to industry: an economic analysis. Economic Policy 14 (28), 13-53......Comment on: Besley and Seabright (1999) The effects and policy implications of state aid to industry: an economic analysis. Economic Policy 14 (28), 13-53...

  7. 78 FR 10002 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-02-12

    ... comments should be received on or before April 15, 2013 to be assured of consideration. ADDRESSES: Direct...: FI-59-91. Abstract: This regulation relates to the tax treatment of debt instruments that provide for... an integrated transaction. The regulation provides general rules, definitions, and reporting and...

  8. Asymptotic expansion of the Keesom integral

    International Nuclear Information System (INIS)

    Abbott, Paul C

    2007-01-01

    The asymptotic evaluation and expansion of the Keesom integral, K(a), is discussed at some length in Battezzati and Magnasco (2004 J. Phys. A: Math. Gen. 37 9677; 2005 J. Phys. A: Math. Gen. 38 6715). Here, using standard identities, it is shown that this triple integral can be reduced to a single integral from which the asymptotic behaviour is readily obtained using Laplace's method. (comment)

  9. Opinion Summarizationof CustomerComments

    Science.gov (United States)

    Fan, Miao; Wu, Guoshi

    Web 2.0 technologies have enabled more and more customers to freely comment on different kinds of entities, such as sellers, products and services. The large scale of information poses the need and challenge of automatic summarization. In many cases, each of the user-generated short comments implies the opinions which rate the target entity. In this paper, we aim to mine and to summarize all the customer comments of a product. The algorithm proposed in this researchis more reliable on opinion identification because it is unsupervised and the accuracy of the result improves as the number of comments increases. Our research is performed in four steps: (1) mining the frequent aspects of a product that have been commented on by customers; (2) mining the infrequent aspects of a product which have been commented by customers (3) identifying opinion words in each comment and deciding whether each opinion word is positive, negative or neutral; (4) summarizing the comments. This paper proposes several novel techniques to perform these tasks. Our experimental results using comments of a number of products sold online demonstrate the effectiveness of the techniques.

  10. PhD students and integrative research

    NARCIS (Netherlands)

    Fry, G.; Tress, B.; Tress, G.

    2006-01-01

    The training of PhD students is currently very dynamic and varies widely from place to place. We present some examples of this variation and comment on how it may affect the way PhD students cope with integrative studies. Our focus is on the training needs of PhD students studying integrative

  11. 76 FR 25331 - Agency Information Collection Activities; Proposed Collection; Comment Request; National Oil and...

    Science.gov (United States)

    2011-05-04

    ... Activities; Proposed Collection; Comment Request; National Oil and Hazardous Substance Pollution Contingency... http://www.regulations.gov to obtain a copy of the draft collection of information, submit or view... comments: 1. Explain your views as clearly as possible and provide specific examples. 2. Describe any...

  12. Environmental challenges and opportunities of the evolving North American electricity market : Government comments on Environmental Challenges and Opportunities of the evolving North American electricity market: Secretariat report to Council under article 13 of the North American Agreement on Environmental Cooperation : Canada, Mexico, United States

    International Nuclear Information System (INIS)

    2002-06-01

    Canada, Mexico, and the United States commented in turn on the issues related to the integration of the North American electricity market. Canada indicated that the report was based on on specific sets of data, analyses, and several assumptions. It provides a starting point for further discussions as information and analyses are further improved. Four categories of issues were identified: transboundary airshed management, innovative economic instruments, energy efficiency and renewable energy, and information planning and transboundary cumulative impact assessment. Some of those areas are already the subject of improved cooperation. Mexico mentioned that the major problem was one of pollution in geographically shared but jurisdictionally divided regions. This situation could lead to preferences in the selection of locations for power generation plants, as environmental rules differ. The suggestions made in the report do not always reflect the approaches being discussed in Mexico. Some specific comments about the various working papers were offered. The United States stated that the report provides a solid foundation for further discussions on the topic. The United States also indicated that further qualification, analysis, and/or discussion is required on some important issues. It felt that the future growth, continental-scale integration, and environmental impacts related to the electricity sector had been overestimated. More comprehensive comparisons between the three countries would benefit the entire process. More specific comments were included

  13. 77 FR 11115 - Mobility Fund Phase I Auction Limited Extension of Deadlines for Comments and Reply Comments on...

    Science.gov (United States)

    2012-02-24

    ... FEDERAL COMMUNICATIONS COMMISSION [AU Docket No. 12-25; DA 12-236] Mobility Fund Phase I Auction... the Mobility Fund Phase I Auction Limited Extension of Comment Deadlines Public Notice (Public Notice... respect to the potential eligibility of specific census blocks for Mobility Fund Phase I support by March...

  14. Neutrophil glycoprotein Mo1 is an integral membrane protein of plasma membranes and specific granules

    International Nuclear Information System (INIS)

    Stevenson, K.B.; Nauseef, W.M.; Clark, R.A.

    1987-01-01

    The glucoprotein Mo1 has previously been demonstrated to be on the cell surface and in the specific granule fraction of neutrophils and to be translocated to the cell surface during degranulation. It is not known, however, whether Mo1 is an integral membrane protein or a soluble, intragranular constituent loosely associated with the specific granule membrane. Purified neutrophils were disrupted by nitrogen cavitation and separated on Percoll density gradients into four fractions enriched for azurophilic granules, specific granules, plasma membrane, and cytosol, respectively. The glycoproteins in these fractions were labeled with 3 H-borohydride reduction, extracted with Triton X-114, and immunoprecipitated with 60.3, an anti-Mo1 monoclonal antibody. Mo1 was detected only in the specific granule and plasma membrane fractions and partitioned exclusively into the detergent-rich fraction consistent with Mo1 being an integral membrane protein. In addition, treatment of specific granule membranes with a high salt, high urea buffer to remove adsorbed or peripheral proteins failed to dissociate Mo1. These data support the hypothesis that Mo1 is an integral membrane protein of plasma and specific granule membranes in human neutrophils

  15. 75 FR 9275 - Proposed Collection; Comment Request

    Science.gov (United States)

    2010-03-01

    ... INFORMATION: Title: New Markets Tax Credit (NMTC) Allocation Tracking System. OMB Number: 1559-0024. Abstract... and recipients of tax credit authority allocations through New Markets Tax Credit (NMTC). The specific... comments should be received on or before April 30, 2010 to be assured of consideration. ADDRESSES: Direct...

  16. Comment on the Adler-Bardeen theorem and related problems

    International Nuclear Information System (INIS)

    Fujikawa, Kazuo

    1987-06-01

    Some aspects of the constructive proof of the Adler-Bardeen theorem in the sense of exact bare identities are discussed by using the higher derivative regularization. It is argued that the formal path integral derivation of chiral and scale (counting identity) anomalies is compatible with the construction of those regularized Green's functions. We also comment on the T*-product in the Lagrangian formalism and discuss how the complications associated with the (anomalous) symmetry charges in the operator approach are avoided in a suitably defined path integral formalism. (author)

  17. Response to state comments on the revised draft northeastern regional characterization reports for the Crystalline Repository Project

    International Nuclear Information System (INIS)

    1985-08-01

    The purpose of this document is to respond to the comments received from the States of the Northeastern Region on the revised draft Northeastern Regional Characterization Reports (RCRs). The responses in this document indicate the manner in which the suggestions or comments received have been considered in modifying the revised draft Northeastern RCRs. Both general comments related to the overall Crystalline Repository Project (CRP) and comments on specific sections of the RCRs are addressed. This document responds to Northeastern State comments on both the revised draft Northeastern Regional Geologic Characterization Report (RGCR) and the revised draft Northeastern Regional Environmental Characterization Report (RECR)

  18. Response to state comments on the revised draft Southeastern Regional Characterization Reports for the Crystalline Repository Project

    International Nuclear Information System (INIS)

    1985-08-01

    The purpose of this document is to respond to the comments received from the states of the Southeastern Region on the revised draft Southeastern Regional Characterization Reports (RCRs). The responses in this document indicate the manner in which the suggestions or comments received have been considered in modifying the revised draft Southeastern RCRs. Both general comments related to the overall Crystalline Repository Project (CRP) and comments on specific sections of the RCRs are addressed. This document responds to Southeastern State comments on both the revised draft Southeastern Regional Geologic Characterization Report (RGCR) and the revised draft Southeastern Regional Environmental Characterization Report (RECR)

  19. SELECTED REQUIREMENTS OF INTEGRATED MANAGEMENT SYSTEMS BASED ON PAS 99 SPECIFICATION

    Directory of Open Access Journals (Sweden)

    Paweł Nowicki

    2013-03-01

    Full Text Available The aim this research was to analyze the ways of integration of management systems in food sector. The study involved the documentation, audits, corrective and preventive actions and management's review phases described in the specification PAS 99, which is one of common elements of integrated management systems. Four organizations were selected for the study. The organizations had introduced and certified at least two standardized management systems. It was assumed that the investigated organizations should have implemented the HACCP system. Studies were conducted as a case study. The employees responsible for the functioning of management systems were interviewed in all four organizations. The study was conducted in the form of in-depth interviews based on pre-prepared script. The scenario was developed based on the PAS 99 guideline. The process of integration of management systems implemented in the studied companies reveals the full compliance of an integrated management system with PASS 99 in the policy area.

  20. Theory and Metatheory in the Study of Dual Processing: Reply to Comments.

    Science.gov (United States)

    Evans, Jonathan St B T; Stanovich, Keith E

    2013-05-01

    In this article, we respond to the four comments on our target article. Some of the commentators suggest that we have formulated our proposals in a way that renders our account of dual-process theory untestable and less interesting than the broad theory that has been critiqued in recent literature. Our response is that there is a confusion of levels. Falsifiable predictions occur not at the level of paradigm or metatheory-where this debate is taking place-but rather in the instantiation of such a broad framework in task level models. Our proposal that many dual-processing characteristics are only correlated features does not weaken the testability of task-level dual-processing accounts. We also respond to arguments that types of processing are not qualitatively distinct and discuss specific evidence disputed by the commentators. Finally, we welcome the constructive comments of one commentator who provides strong arguments for the reality of the dual-process distinction. © The Author(s) 2013.

  1. Integrating Occupational Therapy Specific Assessments in Practice: Exploring Practitioner Experiences

    Directory of Open Access Journals (Sweden)

    Eric Asaba

    2017-01-01

    Full Text Available Background. Occupational therapists sometimes find it challenging to integrate client-centered and occupational therapy specific assessments in practice. The aim of this study was to explore the use of occupational therapy specific assessments such as the Assessment of Motor and Process Skills (AMPS among occupational therapists in Sweden and Japan. Methods. Interviews and qualitative thematic analyses were utilized. Findings. Four themes are reported: (1 use it or lose it, (2 simply no space until after hours, (3 biggest barriers can be colleagues, and (4 being more specific: communication. Conclusion. In keeping with previous studies, occupational therapists often find it challenging to implement client-centered and occupation-based assessment tools into practice. However, more work is needed to understand how best practices can be incorporated into a changing occupational therapy daily practice.

  2. Attitudes towards chiropractic: an analysis of written comments from a survey of north american orthopaedic surgeons

    Directory of Open Access Journals (Sweden)

    Busse Jason W

    2011-10-01

    Full Text Available Abstract Background There is increasing interest by chiropractors in North America regarding integration into mainstream healthcare; however, there is limited information about attitudes towards the profession among conventional healthcare providers, including orthopaedic surgeons. Methods We administered a 43-item cross-sectional survey to 1000 Canadian and American orthopaedic surgeons that inquired about demographic variables and their attitudes towards chiropractic. Our survey included an option for respondants to include written comments, and our present analysis is restricted to these comments. Two reviewers, independantly and in duplicate, coded all written comments using thematic analysis. Results 487 surgeons completed the survey (response rate 49%, and 174 provided written comments. Our analysis revealed 8 themes and 24 sub-themes represented in surgeons' comments. Reported themes were: variability amongst chiropractors (n = 55; concerns with chiropractic treatment (n = 54; areas where chiropractic is perceived as effective (n = 43; unethical behavior (n = 43; patient interaction (n = 36; the scientific basis of chiropractic (n = 26; personal experiences with chiropractic (n = 21; and chiropractic training (n = 18. Common sub-themes endorsed by surgeon's were diversity within the chiropractic profession as a barrier to increased interprofessional collaboration, endorsement for chiropractic treatment of musculoskeletal complaints, criticism for treatment of non-musculoskeletal complaints, and concern over whether chiropractic care was evidence-based. Conclusions Our analysis identified a number of issues that will have to be considered by the chiropractic profession as part of its efforts to further integrate chiropractic into mainstream healthcare.

  3. Recommendations and comments on the report of the Ontario Nuclear Safety Review

    International Nuclear Information System (INIS)

    1988-12-01

    The report of the Ontario Nuclear Safety Review (ONSR) prepared by Dr. F. Kenneth Hare in March 1988, is reviewed by the Advisory Committee on Nuclear Safety (ACNS) to assess for the Atomic Energy Control Board the relevance and importance of the ONSR recommendations and comments. The ACNS conclusions from this study are embodied in nineteen recommendations, as well as several suggestions and some specific comments

  4. 76 FR 59399 - Proposed Information Collection Activity; Comment Request

    Science.gov (United States)

    2011-09-26

    ... organizations such as their organizational structure, program services, populations served, and specific... DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration for Children and Families Proposed Information Collection Activity; Comment Request Title: Responsible Fatherhood Reentry Strategies Study...

  5. Media brand loyalty through online audience integration?

    OpenAIRE

    Lischka, Juliane A

    2015-01-01

    This chapter discusses the question whether audience members become loyal toward a media brand when sharing, liking or commenting on online media content – or are loyal readers more inclined to write comments on online articles or to like and share them? The aim is to answer this chicken-egg causality dilemma on the audience integration-loyalty relation on a theoretical basis. Therefore, the concept of attitude-behavior consistency, the theory of reasoned action, involvement theory, uses and ...

  6. A CNN-Specific Integrated Processor

    Directory of Open Access Journals (Sweden)

    Suleyman Malki

    2009-01-01

    Full Text Available Integrated Processors (IP are algorithm-specific cores that either by programming or by configuration can be re-used within many microelectronic systems. This paper looks at Cellular Neural Networks (CNN to become realized as IP. First current digital implementations are reviewed, and the memoryprocessor bandwidth issues are analyzed. Then a generic view is taken on the structure of the network, and a new intra-communication protocol based on rotating wheels is proposed. It is shown that this provides for guaranteed high-performance with a minimal network interface. The resulting node is small and supports multi-level CNN designs, giving the system a 30-fold increase in capacity compared to classical designs. As it facilitates multiple operations on a single image, and single operations on multiple images, with minimal access to the external image memory, balancing the internal and external data transfer requirements optimizes the system operation. In conventional digital CNN designs, the treatment of boundary nodes requires additional logic to handle the CNN value propagation scheme. In the new architecture, only a slight modification of the existing cells is necessary to model the boundary effect. A typical prototype for visual pattern recognition will house 4096 CNN cells with a 2% overhead for making it an IP.

  7. ITER ISS system alternative specification study

    International Nuclear Information System (INIS)

    Kveton, O.K.

    1990-08-01

    Recent comments suggested that the fuel systems, in particular the ISS, could be simplified if the ITER specifications were relaxed from the data specified for ITER. This interim report addresses the first part of the analysis, which considers the impact of design specifications on fuel systems design

  8. Grand Theories of Personality Cannot Be Integrated

    Science.gov (United States)

    Wood, Alex; Joseph, Stephen

    2007-01-01

    Comments on the original article "A New Big Five: Fundamental Principles for an Integrative Science of Personality," by Dan P. McAdams and Jennifer L. Pals (see record 2006-03947-002). McAdams and Pals (April 2006) presented a new model to integrate the field of personality psychology. Cultural and evolutionary factors interact with an…

  9. Integrating Cloud-Computing-Specific Model into Aircraft Design

    Science.gov (United States)

    Zhimin, Tian; Qi, Lin; Guangwen, Yang

    Cloud Computing is becoming increasingly relevant, as it will enable companies involved in spreading this technology to open the door to Web 3.0. In the paper, the new categories of services introduced will slowly replace many types of computational resources currently used. In this perspective, grid computing, the basic element for the large scale supply of cloud services, will play a fundamental role in defining how those services will be provided. The paper tries to integrate cloud computing specific model into aircraft design. This work has acquired good results in sharing licenses of large scale and expensive software, such as CFD (Computational Fluid Dynamics), UG, CATIA, and so on.

  10. Site-Specific Integration of Exogenous Genes Using Genome Editing Technologies in Zebrafish

    Directory of Open Access Journals (Sweden)

    Atsuo Kawahara

    2016-05-01

    Full Text Available The zebrafish (Danio rerio is an ideal vertebrate model to investigate the developmental molecular mechanism of organogenesis and regeneration. Recent innovation in genome editing technologies, such as zinc finger nucleases (ZFNs, transcription activator-like effector nucleases (TALENs and the clustered regularly interspaced short palindromic repeats (CRISPR/CRISPR associated protein 9 (Cas9 system, have allowed researchers to generate diverse genomic modifications in whole animals and in cultured cells. The CRISPR/Cas9 and TALEN techniques frequently induce DNA double-strand breaks (DSBs at the targeted gene, resulting in frameshift-mediated gene disruption. As a useful application of genome editing technology, several groups have recently reported efficient site-specific integration of exogenous genes into targeted genomic loci. In this review, we provide an overview of TALEN- and CRISPR/Cas9-mediated site-specific integration of exogenous genes in zebrafish.

  11. Sound specificity effects in spoken word recognition: The effect of integrality between words and sounds

    DEFF Research Database (Denmark)

    Strori, Dorina; Zaar, Johannes; Cooke, Martin

    2017-01-01

    Recent evidence has shown that nonlinguistic sounds co-occurring with spoken words may be retained in memory and affect later retrieval of the words. This sound-specificity effect shares many characteristics with the classic voice-specificity effect. In this study, we argue that the sound......-specificity effect is conditional upon the context in which the word and sound coexist. Specifically, we argue that, besides co-occurrence, integrality between words and sounds is a crucial factor in the emergence of the effect. In two recognition-memory experiments, we compared the emergence of voice and sound...... from a mere co-occurrence context effect by removing the intensity modulation. The absence of integrality led to the disappearance of the sound-specificity effect. Taken together, the results suggest that the assimilation of background sounds into memory cannot be reduced to a simple context effect...

  12. Integrating place-specific livelihood and equity outcomes into global assessments of bioenergy deployment

    International Nuclear Information System (INIS)

    Creutzig, Felix; Corbera, Esteve; Bolwig, Simon; Hunsberger, Carol

    2013-01-01

    Integrated assessment models suggest that the large-scale deployment of bioenergy could contribute to ambitious climate change mitigation efforts. However, such a shift would intensify the global competition for land, with possible consequences for 1.5 billion smallholder livelihoods that these models do not consider. Maintaining and enhancing robust livelihoods upon bioenergy deployment is an equally important sustainability goal that warrants greater attention. The social implications of biofuel production are complex, varied and place-specific, difficult to model, operationalize and quantify. However, a rapidly developing body of social science literature is advancing the understanding of these interactions. In this letter we link human geography research on the interaction between biofuel crops and livelihoods in developing countries to integrated assessments on biofuels. We review case-study research focused on first-generation biofuel crops to demonstrate that food, income, land and other assets such as health are key livelihood dimensions that can be impacted by such crops and we highlight how place-specific and global dynamics influence both aggregate and distributional outcomes across these livelihood dimensions. We argue that place-specific production models and land tenure regimes mediate livelihood outcomes, which are also in turn affected by global and regional markets and their resulting equilibrium dynamics. The place-specific perspective suggests that distributional consequences are a crucial complement to aggregate outcomes; this has not been given enough weight in comprehensive assessments to date. By narrowing the gap between place-specific case studies and global models, our discussion offers a route towards integrating livelihood and equity considerations into scenarios of future bioenergy deployment, thus contributing to a key challenge in sustainability sciences. (letter)

  13. Integrating place-specific livelihood and equity outcomes into global assessments of bioenergy deployment

    Science.gov (United States)

    Creutzig, Felix; Corbera, Esteve; Bolwig, Simon; Hunsberger, Carol

    2013-09-01

    Integrated assessment models suggest that the large-scale deployment of bioenergy could contribute to ambitious climate change mitigation efforts. However, such a shift would intensify the global competition for land, with possible consequences for 1.5 billion smallholder livelihoods that these models do not consider. Maintaining and enhancing robust livelihoods upon bioenergy deployment is an equally important sustainability goal that warrants greater attention. The social implications of biofuel production are complex, varied and place-specific, difficult to model, operationalize and quantify. However, a rapidly developing body of social science literature is advancing the understanding of these interactions. In this letter we link human geography research on the interaction between biofuel crops and livelihoods in developing countries to integrated assessments on biofuels. We review case-study research focused on first-generation biofuel crops to demonstrate that food, income, land and other assets such as health are key livelihood dimensions that can be impacted by such crops and we highlight how place-specific and global dynamics influence both aggregate and distributional outcomes across these livelihood dimensions. We argue that place-specific production models and land tenure regimes mediate livelihood outcomes, which are also in turn affected by global and regional markets and their resulting equilibrium dynamics. The place-specific perspective suggests that distributional consequences are a crucial complement to aggregate outcomes; this has not been given enough weight in comprehensive assessments to date. By narrowing the gap between place-specific case studies and global models, our discussion offers a route towards integrating livelihood and equity considerations into scenarios of future bioenergy deployment, thus contributing to a key challenge in sustainability sciences.

  14. Safe genetic modification of cardiac stem cells using a site-specific integration technique.

    Science.gov (United States)

    Lan, Feng; Liu, Junwei; Narsinh, Kazim H; Hu, Shijun; Han, Leng; Lee, Andrew S; Karow, Marisa; Nguyen, Patricia K; Nag, Divya; Calos, Michele P; Robbins, Robert C; Wu, Joseph C

    2012-09-11

    Human cardiac progenitor cells (hCPCs) are a promising cell source for regenerative repair after myocardial infarction. Exploitation of their full therapeutic potential may require stable genetic modification of the cells ex vivo. Safe genetic engineering of stem cells, using facile methods for site-specific integration of transgenes into known genomic contexts, would significantly enhance the overall safety and efficacy of cellular therapy in a variety of clinical contexts. We used the phiC31 site-specific recombinase to achieve targeted integration of a triple fusion reporter gene into a known chromosomal context in hCPCs and human endothelial cells. Stable expression of the reporter gene from its unique chromosomal integration site resulted in no discernible genomic instability or adverse changes in cell phenotype. Namely, phiC31-modified hCPCs were unchanged in their differentiation propensity, cellular proliferative rate, and global gene expression profile when compared with unaltered control hCPCs. Expression of the triple fusion reporter gene enabled multimodal assessment of cell fate in vitro and in vivo using fluorescence microscopy, bioluminescence imaging, and positron emission tomography. Intramyocardial transplantation of genetically modified hCPCs resulted in significant improvement in myocardial function 2 weeks after cell delivery, as assessed by echocardiography (P=0.002) and MRI (P=0.001). We also demonstrated the feasibility and therapeutic efficacy of genetically modifying differentiated human endothelial cells, which enhanced hind limb perfusion (Pmodification system is a safe, efficient tool to enable site-specific integration of reporter transgenes in progenitor and differentiated cell types.

  15. Chemical Entity Semantic Specification: Knowledge representation for efficient semantic cheminformatics and facile data integration

    Science.gov (United States)

    2011-01-01

    Background Over the past several centuries, chemistry has permeated virtually every facet of human lifestyle, enriching fields as diverse as medicine, agriculture, manufacturing, warfare, and electronics, among numerous others. Unfortunately, application-specific, incompatible chemical information formats and representation strategies have emerged as a result of such diverse adoption of chemistry. Although a number of efforts have been dedicated to unifying the computational representation of chemical information, disparities between the various chemical databases still persist and stand in the way of cross-domain, interdisciplinary investigations. Through a common syntax and formal semantics, Semantic Web technology offers the ability to accurately represent, integrate, reason about and query across diverse chemical information. Results Here we specify and implement the Chemical Entity Semantic Specification (CHESS) for the representation of polyatomic chemical entities, their substructures, bonds, atoms, and reactions using Semantic Web technologies. CHESS provides means to capture aspects of their corresponding chemical descriptors, connectivity, functional composition, and geometric structure while specifying mechanisms for data provenance. We demonstrate that using our readily extensible specification, it is possible to efficiently integrate multiple disparate chemical data sources, while retaining appropriate correspondence of chemical descriptors, with very little additional effort. We demonstrate the impact of some of our representational decisions on the performance of chemically-aware knowledgebase searching and rudimentary reaction candidate selection. Finally, we provide access to the tools necessary to carry out chemical entity encoding in CHESS, along with a sample knowledgebase. Conclusions By harnessing the power of Semantic Web technologies with CHESS, it is possible to provide a means of facile cross-domain chemical knowledge integration with full

  16. Comments received on proposed rule on radiological criteria for decommissioning and related documents

    International Nuclear Information System (INIS)

    Page, G.; Caplin, J.; Smith, D.

    1996-03-01

    The Nuclear Regulatory Commission (NRC) is conducting an enhanced participatory rulemaking to establish radiological criteria for the decommissioning of NRC-licensed facilities. As a part of this action, the Commission published in the Federal Register (59 FR 43200), on August 22, 1994, a proposed rule on radiological criteria for decommissioning, soliciting comments both on the rule as proposed and on certain specific items as identified in its supplementary statement of considerations. A draft Generic Environmental Impact Statement (GEIS) in support of the rule, also published in August 1994 as NUREG-1496, along with its Appendix A (NUREG-1501), were also made available for comment. A staff working draft on regulatory guidance (NUREG-1500)was also made available. This report summarizes the 1,309 comments on the proposed rule and supplementary items and the 311 comments on the GEIS as excerpted from 101 docketed letters received associated in the Federal/Register notice. Comments from two NRC/Agreement-States meetings are also summarized

  17. Integrative Treatment of Personality Disorder. Part I: Psychotherapy.

    Science.gov (United States)

    Jovanovic, Mirjana Divac; Svrakic, Dragan

    2017-03-01

    In this paper, we outline the concept of integrative therapy of borderline personality, also referred to as fragmented personality, which we consider to be the core psychopathology underlying all clinical subtypes of personality disorder. Hence, the terms borderline personality, borderline disorder, fragmented personality, and personality disorder are used interchangeably, as synonyms. Our integrative approach combines pharmacotherapy and psychotherapy, each specifically tailored to accomplish a positive feedback modulation of their respective effects. We argue that pharmacotherapy and psychotherapy of personality disorder complement each other. Pharmacological control of disruptive affects clears the stage, in some cases builds the stage, for the psychotherapeutic process to take place. In turn, psychotherapy promotes integration of personality fragments into more cohesive structures of self and identity, ultimately establishing self-regulation of mood and anxiety. We introduce our original method of psychotherapy, called reconstructive interpersonal therapy (RIT). The RIT integrates humanistic-existential and psychodynamic paradigms, and is thereby designed to accomplish a deep reconstruction of core psychopathology within the setting of high structure. We review and comment the current literature on the strategies, goals, therapy process, priorities, and phases of psychotherapy of borderline disorders, and describe in detail the fundamental principles of RIT.

  18. 75 FR 81615 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2010-12-28

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration for Children and Families Submission for... Specific Consent. OMB No.: New Collection. Description: The William Wilberforce Trafficking Victims... effect if OMB receives it within 30 days of publication. Written comments and recommendations for the...

  19. Comment on 'Conservative discretizations of the Kepler motion'

    International Nuclear Information System (INIS)

    Cieslinski, Jan L

    2010-01-01

    We show that the exact integrator for the classical Kepler motion, recently found by Kozlov (2007 J. Phys. A: Math. Theor. 40 4529-39), can be derived in a simple natural way, using a well-known exact discretization of the harmonic oscillator. We also draw attention to important earlier references, where the exact discretization of the four-dimensional isotropic harmonic oscillator has been applied to the perturbed Kepler problem. (comments and replies)

  20. 78 FR 22277 - Notice of Proposed Information Collection: Comment Request Office of Sustainable Housing...

    Science.gov (United States)

    2013-04-15

    ... Information Collection: Comment Request Office of Sustainable Housing Communities Progress Report Template AGENCY: Office of Sustainable Housing and Communities (OSHC), HUD. ACTION: Notice. SUMMARY: The proposed... Sustainable Communities Initiative to improve regional planning efforts that integrate housing and...

  1. Response to state comments on the revised draft North Central Regional characterization reports for the Crystalline Repository Project

    International Nuclear Information System (INIS)

    1985-08-01

    The purpose of this document is to respond to the comments received from the states of the North Central Region on the revised draft North Central Regional Characterization Reports (RCRs). The responses in this document indicate the manner in which the suggestions or comments received have been considered in modifying the revised draft North Central RCRs. Both general comments related to the overall Crystalline Repository Project (CRP) and comments on specific sections of the RCRs are addressed. This document responds to North Central State comments on both the revised draft North Central Regional Geologic Characterization Report (RGCR) and the revised draft North Central Regional Environmental Characterization Report (RECR)

  2. INTEGRATING COUNTRY-SPECIFIC CULTURE IN THE BRANDING STRATEGY FOR BUILDING GLOBAL SUCCESS

    Directory of Open Access Journals (Sweden)

    Alexandra IOANID

    2014-11-01

    Full Text Available A strong brand is the one that integrates its cultural origins and values with the cultural values of the countries where it operates, building relationships based on trust with the local consumers. The chances for a company to gain share market when starting operations in a new country grows a lot if the management allows enough regional flexibility on how the brands are marketed, according to the cultural characteristics of the potential local customers. In the actual globalized business environment, the brand marketer has the choice to adopt a global or a local approach in the marketing strategy, that most of the times determines the success or the failure of the business in a specific country. An important challenge for any marketer is the integration of the brand-culture with the country-culture and in this context, the paper analyses different cultures and offers some branding strategies valid for both products and services. This paper aims to demonstrate the importance of the country-specific culture integration in the marketing strategy of a company for growing the effectiveness of all its operations. The ideas mentioned in this paper are based on literature research and also on authors’ experience with multicultural environments.

  3. 78 FR 24392 - Agency Information Collection Activities; Comment Request; Evaluation and Accountability Report...

    Science.gov (United States)

    2013-04-25

    ... integrating technology into curricula and instruction and improving student achievement. The purpose of this... positive impacts for student learning, and can be widely replicated by other State educational agencies and... respondents, including through the use of information technology. Please note that written comments received...

  4. Anatomy and history of an external quality assessment program for interpretative comments in clinical biochemistry.

    Science.gov (United States)

    Vasikaran, Samuel D

    2015-05-01

    The provision of clinical interpretation of results, either verbally or in the printed report, may be considered an integral part of clinical biochemistry diagnostic service. Proficiency testing or external quality assessment (EQA) of such activity may be useful in education, training, continuing professional development and ensuring the quality of such service. Details of the Patient Report Comments Program (RPCProgram) developed by the Royal College of Pathologists of Australasia (RCPA) Chemical Pathology Quality Assurance Programs Pty Ltd (QAP) is described in this review. The program is aimed at pathologists, clinical scientists and trainees. Registered participants are provided a report with case details and a set of clinical biochemistry results at monthly intervals and submit an interpretative comment for the report. Comments received are broken up into components that are translated into common key phrases. An expert panel evaluates the key phrases, classifies them according to appropriateness and drafts a suggested comment, a case summary and a rationale, which are included in a summary report returned to participants. There is considerable diversity in the quality of interpretative comments received from participants of the PRCProgram. The primary purpose of EQA of interpretative commenting is educational self-assessment, and they are recognized as a continuing professional development activity. Whilst there is some evidence for the utility of interpretative comments in improving patient outcomes, evidence for the utility of EQA in improving quality of comments is awaited. Copyright © 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  5. Application specific integrated circuits and hybrid micro circuits for nuclear instrumentation

    International Nuclear Information System (INIS)

    Chandratre, V.B.; Sukhwani, Menka; Mukhopadhyay, P.K.; Shastrakar, R.S.; Sudheer, M.; Shedam, V.; Keni, Anubha

    2009-01-01

    Rapid development in semiconductor technology, sensors, detectors and requirements of high energy physics experiments as well as advances in commercially available nuclear instruments have lead to challenges for instrumentation. These challenges are met with development of Application Specific Integrated Circuits and Hybrid Micro Circuits. This paper discusses various activities in ASIC and HMC development in Bhabha Atomic Research Centre. (author)

  6. Response to comments background document for the Third Third land-disposal restrictions proposed rule November 22, 1989 (54 FR 48372). Volume 2-2. Capacity-related comments

    International Nuclear Information System (INIS)

    1990-01-01

    On November 22, 1989, the Environmental Protection Agency (EPA, the Agency) proposed a rule to prohibit the land disposal of the final third of the schedule of restricted hazardous wastes, known as the Third Third (see 54 Federal Register 48372). The proposal outlined treatment standards and effective dates of prohibition for these wastes as well as for some First and Second Third soft hammer wastes, characteristic wastes, certain waste groups (e.g., multi-source leachate, radioactive mixed waste), and newly listed wastes. The proposed rule was issued pursuant to the 1984 Hazardous and Solid Waste Amendments (HSWA) to the Resource Conservation and Recovery Act (RCRA). The Agency requested public comment on the proposal. The regulated community, environmental organizations, trade associations, State and Federal agencies, and concerned citizens submitted over 300 written letters on the proposed rule. EPA developed three volumes of a comment response document. This document (Volume 2 of 3) presents a summary of and responses to capacity-related comments received by the EPA docket clerk in response to the proposed rule. The comments have been divided into 17 chapters, each addressing specific comment categories. This volume contains Chapters 8-12. These chapters discuss mercury wastes, other metals, F, K, U, and P wastes, KO48-KO52 wastes, and deepwell injected wastes

  7. 78 FR 47814 - Data Collection Available for Public Comments

    Science.gov (United States)

    2013-08-06

    ... only the relevant information to the audience member's specific needs, Information is also collected to... information, contribute information, and interact with SBA and other users of the site. Description of... approved information collection. DATES: Submit comments on or before October 7, 2013. ADDRESSES: Send all...

  8. 77 FR 189 - Federal Acquisition Regulation; Brand-Name Specifications

    Science.gov (United States)

    2012-01-03

    ... 2006-0020, Sequence 26] RIN 9000-AK55 Federal Acquisition Regulation; Brand-Name Specifications... Management and Budget memoranda on brand-name specifications. DATES: Effective Date: February 2, 2012. FOR... brand- name specifications. Eight respondents submitted 32 comments in response to the interim rule. The...

  9. Students' Responses to Teacher Comments

    Science.gov (United States)

    Gee, Thomas C.

    1972-01-01

    In an investigation of the effects of praise, negative comment and no comment on expository compositions of eleventh grade students, author hypothesized that praise might increase motivation more than criticism or no comment. He suggests an experiment to test this phypothesis. (NL)

  10. Comment and response document for the long-term surveillance plan for the Bodo Canyon Disposal Site, Durango, Colorado, Revision 0

    International Nuclear Information System (INIS)

    1995-11-01

    This report contains the comment and response document for the Draft Long-Term Surveillance Plan of the Bodo Canyon Site in Durango, California. This is a part of the Uranium Mill Tailings Remedial Action (UMTRA) Project. Questions and comments regarding specific sections or statements in the report are described and then a response to each review comment or question is provided

  11. 77 FR 10533 - Proposed Information Collection Activity; Comment Request

    Science.gov (United States)

    2012-02-22

    ... employment and public assistance. The guide will be used to interview respondents in order to learn about...; use of public benefit programs and reasons for using or not using specific benefits; their financial... technology. Consideration will be given to comments and suggestions submitted within 60 days of this...

  12. 78 FR 24151 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-04-24

    ... and clearance under the Paperwork Reduction Act of 1995, Public Law 104-13. Comments regarding (a... of information unless it displays a currently valid OMB control number. Forest Service Title: Bid for... appraised value; bidders meet specific criteria when submitting a bid; and anti-trust violations do not...

  13. 76 FR 57037 - Proposed Agency Information Collection Activities; Comment Request

    Science.gov (United States)

    2011-09-15

    ... two types of authentication mechanisms: dual-message transactions (those generally requiring a... specifically requests comment on the following: a. The best terms to use in identifying types of authentication... card programs that use two types of authentication mechanisms: Dual-message transactions (those...

  14. Recommendations for resolution of public comments on USI [Unresolved Safety Issues] A-40, ''Seismic Design Criteria''

    International Nuclear Information System (INIS)

    Philippacopoulos, A.J.

    1989-06-01

    In June 1988 the Nuclear Regulatory Commission (NRC) issued for public comment the proposed Revision 2 of the Standard Review Plan (SRP) Sections 2.5.2, 3.7.1, 3.7.2. and 3.7.3. Comments were received from six organizations. Brookhaven National Laboratory (BNL) was requested by NRC to provide expert consultation in the seismic and soil-structure interaction areas for the review and resolution of these comments. For this purpose, a panel of consultants was established to assist BNL with the review and evaluation of the public comments. This review was carried out during the period of October 1988 through January 1989. Many of the suggestions given in the public comments were found to be significant and a number of modifications to appropriate SRP sections are recommended. Other public comments were found to have no impact on the proposed Revision 2 of the SRP. Major changes are recommended to the SRP sections dealing with (a) Power Spectral Density (PSD) and ground motion requirements and (b) soil-structure interaction requirements. This report contains specific recommendations to NRC for resolution of the public comments made on the proposed Revision 2 of the SRP

  15. Integrating Hypnosis with Other Therapies for Treating Specific Phobias: A Case Series.

    Science.gov (United States)

    Hirsch, Joseph A

    2018-04-01

    There is a high prevalence of anxiety disorders including specific phobias and panic disorder in the United States and Europe. A variety of therapeutic modalities including pharmacotherapy, cognitive behavioral therapy, systematic desensitization, hypnosis, in vivo exposure, and virtual reality exposure therapy have been applied. No one modality has been entirely successful. There has been only a limited attempt to combine psychological therapies in the treatment of specific phobias and panic disorder and what has been done has been primarily with systematic desensitization or cognitive behavioral therapy along with hypnotherapy. I present two cases of multiple specific phobias that were successfully treated with hypnotherapy combined with virtual reality exposure therapy or in vivo exposure therapy. The rationale for this integrative therapy and the neurobiological constructs are considered.

  16. Reply to 'Comment on 'Secure direct communication with a quantum one-time-pad''

    International Nuclear Information System (INIS)

    Deng Fuguo; Long Guilu

    2005-01-01

    We reply to the preceding comment which focused on whether there exists a quantum privacy amplification technique for purifying the unknown single-photon states transmitted. In this Reply, we will show that quantum privacy amplification is principally possible, and a specific scheme for direct communication protocol based on single photons has been constructed and will be published elsewhere. Then the secure direct quantum communication is secure against the attack strategy in the preceding comment by using quantum privacy amplification directly

  17. THE INTEGRATED REPORTING FRAMEWORK: BETWEEN CHALLENGE AND INNOVATION

    Directory of Open Access Journals (Sweden)

    Tudor OPRIȘOR

    2014-06-01

    Full Text Available Integrated Reporting has lately shown a great amount of interest for the business community, as it can offer a greater information value to all types of users. Thus, creating a proper framework for this type of reporting has been a top priority for the regulating bodies, with significant input from other interested parties. This paper aims to analyze the comments submitted to the Consultation Draft and to determine which questions gained more focus. Moreover, through this paper, we intend to reveal which types of respondents were more interested in discussing the Framework and to split them into several groups of interest. Finally, the main goal of the paper is to provide an overview on the discussions leading to the Framework’s final form and to determine how the comment letters can provide further perspectives on the implementation of Integrated Reporting.

  18. Comment on integrability in Dijkgraaf-Vafa {beta}-ensembles

    Energy Technology Data Exchange (ETDEWEB)

    Mironov, A., E-mail: mironov@lpi.ru [Lebedev Physics Institute (Russian Federation); ITEP, Moscow (Russian Federation); Morozov, A., E-mail: morozov@itep.ru [ITEP, Moscow (Russian Federation); Zakirova, Z., E-mail: zolya_zakirova@mail.ru [Kazan Energy State University, Kazan (Russian Federation)

    2012-05-15

    We briefly discuss the recent claims that the ordinary KP/Toda integrability, which is a characteristic property of ordinary eigenvalue matrix models, persists also for the Dijkgraaf-Vafa (DV) partition functions and for the refined topological vertex. We emphasize that in both cases what is meant is a particular representation of partition functions: a peculiar sum over all DV phases in the first case and hiding the deformation parameters in a sophisticated potential in the second case, i.e. essentially a reformulation of some questions in the new theory in the language of the old one. It is at best obscure if this treatment can be made consistent with the AGT relations and even with the quantization of the underlying integrable systems in the Nekrasov-Shatashvili limit, which seem to require a full-scale {beta}-deformation of individual DV partition functions. Thus, it is unclear if the story of integrability is indeed closed by these recent considerations.

  19. Microwaves integrated circuits: hybrids and monolithics - fabrication technology

    International Nuclear Information System (INIS)

    Cunha Pinto, J.K. da

    1983-01-01

    Several types of microwave integrated circuits are presented together with comments about technologies and fabrication processes; advantages and disadvantages in their utilization are analysed. Basic structures, propagation modes, materials used and major steps in the construction of hybrid thin film and monolithic microwave integrated circuits are described. Important technological applications are revised and main activities of the microelectronics lab. of the University of Sao Paulo (Brazil) in the field of hybrid and monolithic microwave integrated circuits are summarized. (C.L.B.) [pt

  20. Field Assessment and Specification Review for Roller-Integrated Compaction Monitoring Technologies

    Directory of Open Access Journals (Sweden)

    David J. White

    2011-01-01

    Full Text Available Roller-integrated compaction monitoring (RICM technologies provide virtually 100-percent coverage of compacted areas with real-time display of the compaction measurement values. Although a few countries have developed quality control (QC and quality assurance (QA specifications, broader implementation of these technologies into earthwork construction operations still requires a thorough understanding of relationships between RICM values and traditional in situ point test measurements. The purpose of this paper is to provide: (a an overview of two technologies, namely, compaction meter value (CMV and machine drive power (MDP; (b a comprehensive review of field assessment studies, (c an overview of factors influencing statistical correlations, (d modeling for visualization and characterization of spatial nonuniformity; and (e a brief review of the current specifications.

  1. 76 FR 40731 - Agency Information Collection Activities; Proposed Collection; Comment Request

    Science.gov (United States)

    2011-07-11

    ... that your comment doesn't include any sensitive personal information, like anyone's Social Security..., media advertisements, as well as manufacturer specification sheets and product brochures, would contain... assumes advertising or promotions managers prepare the disclosures contained in product brochures and...

  2. 76 FR 34287 - Proposed Agency Information Collection Activities; Comment Request

    Science.gov (United States)

    2011-06-13

    ... the Office of Management and Budget (OMB), FRA is soliciting public comment on specific aspects of the........... 1 minute 350 Locomotives. 229.17--Accident Reports......... 744 Railroads...... 1 report 15 minutes... removal tags. 1 minute 17 Preserving Accident Data..... 744 Railroads...... 2,930 data reports. 15 minutes...

  3. Qualitative content analysis of online news media coverage of weight loss surgery and related reader comments.

    Science.gov (United States)

    Glenn, N M; Champion, C C; Spence, J C

    2012-10-01

    The media has the ability to affect public opinion and policy direction. Prevalence of morbid obesity in Canada is increasing; as is the only effective long-term treatment, weight loss surgery (WLS). Limited research has explored media re/presentations of WLS. The purpose of this study was to examine national online news coverage (and reader comments) of WLS using content analysis. We sought to understand the dominant messages being conveyed within the news texts and reader comments, specifically whose voice was represented, who was the intended audience and what was the overall tone. Articles and comments were retrieved from the Canadian Broadcasting Corporation news web site and analysed using line-by-line techniques. Articles were predominantly 'positive/supportive' (63%) in tone and frequently presented the voices and opinions of 'experts' conveying a biomedical perspective. Comments were overwhelmingly 'negative' (56%) and often derogatory including such language as 'piggy' and 'fatty'. Comments were almost exclusively anonymous (99%) and were frequently directed at other commenters (33%) and 'fat' people (6%). The potentially problematic nature of media framing and reader comments, particularly as they could relate to weight-based stigmatization and discrimination is discussed. © 2012 The Authors. Clinical Obesity © 2012 International Association for the Study of Obesity.

  4. 78 FR 33424 - Tobacco Product Analysis; Scientific Workshop; Request for Comments

    Science.gov (United States)

    2013-06-04

    ... different tobacco product types and strengths. 13. The specific method challenges and limitations when... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0212] Tobacco Product Analysis; Scientific Workshop; Request for Comments AGENCY: Food and Drug Administration...

  5. The Principles of Economics from Now until Then: A Comment.

    Science.gov (United States)

    Amacher, Ryan C.

    1988-01-01

    Comments on Bell's article "The Principles of Economics from Now until Then," responding to the author's two general premises as well as citing specific arguments. Concludes that Bell's premises are based on a small and unrepresentative number of textbooks. Many textbooks that present material according to the recommendations were…

  6. 76 FR 21742 - Wireless Telecommunications Bureau Extends Period for Filing Comments and Reply Comments on...

    Science.gov (United States)

    2011-04-18

    ...In this document, the Wireless Telecommunications Bureau extends the deadline for filing comments and reply comments in response to the Public Notice seeking comment on the December 3, 2010 petition for declaratory ruling (Petition) filed by CTIA--The Wireless Association (Petitioners). The Petitioners asked the Federal Communications Commission (Commission) to clarify ``the scope of Section 332(c)(3)(A)'s ban on state and local entry regulation.''

  7. 76 FR 76981 - Request for Public Comments Concerning U.S.-Canada Action Plan for Perimeter Security and...

    Science.gov (United States)

    2011-12-09

    ... Jobs; Integrated Cross-Border Law Enforcement; and Critical Infrastructure and Cybersecurity. Progress... comments submitted electronically containing business confidential information, the file name of the business confidential version should begin with the characters ``BC''. The top of any page containing...

  8. Telephone Flat Geothermal Development Project Environmental Impact Statement Environmental Impact Report. Final: Comments and Responses to Comments

    Energy Technology Data Exchange (ETDEWEB)

    None

    1999-02-01

    This document is the Comments and Responses to Comments volume of the Final Environmental Impact Statement and Environmental Impact Report prepared for the proposed Telephone Flat Geothermal Development Project (Final EIS/EIR). This volume of the Final EIS/EIR provides copies of the written comments received on the Draft EIS/EIR and the leady agency responses to those comments in conformance with the requirements of the National Environmental Policy Act (NEPA) and the California Environmental Quality Act (CEQA).

  9. Comments on EPA's LLW preproposal

    International Nuclear Information System (INIS)

    Littleton, B.K.; Weinstock, L.

    1995-01-01

    The Environmental Protection Agency (EPA) is currently developing standards for the management, storage, and disposal of Low-Level Radioactive Waste (LLW). The Atomic Energy Act delegated EPA, among other provisions, the authority to establish generally applicable standards for the disposal of radioactive waste to ensure that the public and the environment are adequately protected from potential radiation impacts. As an initial effort to open communications on a standard for LLW, the Agency developed a preproposal draft (Preproposal Draft of 40 CFR Part 193 - 30 Nov 94) and circulated it to interested parties for review and comment. The extended comment period ended April 12, 1995. A summary of the comments received and analyzed to date follows. After all comments have been analyzed, the rule will undergo an Agency clearance process and be sent to the Office of Management and Budget for review. After that review, the formal process of publication of the proposed rule in the Federal Register and the formal public comment period will begin

  10. On the complex interaction between mathematics and the sciences of living systems. Comment on "Move me, astonish me...delight my eyes and brain: The Vienna Integrated Model of top-down and bottom-up processes in Art Perception (VIMAP) and corresponding affective, evaluative, and neurophysiological correlates" by Matthew Pelowski et al.

    Science.gov (United States)

    Bellomo, Nicola; Outada, Nisrine

    2017-07-01

    Cultural framework: Our comment looks at the general framework given by the interactions between the so-called ;soft; and ;hard; sciences. Specifically, it looks at the development of a mathematics for living systems. Our comment aims at showing how the interesting survey [11] can contribute to the aforementioned challenging task.

  11. Database specification for the Worldwide Port System (WPS) Regional Integrated Cargo Database (ICDB)

    Energy Technology Data Exchange (ETDEWEB)

    Faby, E.Z.; Fluker, J.; Hancock, B.R.; Grubb, J.W.; Russell, D.L. [Univ. of Tennessee, Knoxville, TN (United States); Loftis, J.P.; Shipe, P.C.; Truett, L.F. [Oak Ridge National Lab., TN (United States)

    1994-03-01

    This Database Specification for the Worldwide Port System (WPS) Regional Integrated Cargo Database (ICDB) describes the database organization and storage allocation, provides the detailed data model of the logical and physical designs, and provides information for the construction of parts of the database such as tables, data elements, and associated dictionaries and diagrams.

  12. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Public Comment Draft)

    Science.gov (United States)

    EPA is developing an Integrated Risk Information System (IRIS) assessment of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and has released the draft assessment for public comment. When final, the assessment will appear on the IRIS database.

  13. Loaded Questions: Internet Commenters' Opinions on Physician-Patient Firearm Safety Conversations.

    Science.gov (United States)

    Knoepke, Christopher E; Allen, Amanda; Ranney, Megan L; Wintemute, Garen J; Matlock, Daniel D; Betz, Marian E

    2017-08-01

    Medical and public health societies advocate that healthcare providers (HCPs) counsel at-risk patients to reduce firearm injury risk. Anonymous online media comments often contain extreme viewpoints and may therefore help in understanding challenges of firearm safety counseling. To help inform injury prevention efforts, we sought to examine commenters' stated opinions regarding firearm safety counseling HCPs. Qualitative descriptive analysis of online comments posted following news items (in May-June, 2016) about a peer-reviewed publication addressing when and how HCPs should counsel patients regarding firearms. Among 871 comments posted by 522 individuals, most (57%) were generally negative toward firearm discussions, 17% were positive, and 26% were neutral/unclear. Two major categories and multiple themes emerged. "Areas of agreement" included that discussions may be valuable (1) when addressing risk of harm to self or others, (2) in pediatric injury prevention, and (3) as general safety education (without direct questioning), and that (4) HCPs lack gun safety and cultural knowledge. "Areas of tension" included whether (1) firearms are a public health issue, (2) counseling is effective prevention practice, (3) suicide could/should be prevented, and (4) firearm safety counseling is within HCPs' purview. Among this set of commenters with likely extreme viewpoints, opinions were generally negative toward firearm safety conversations, but with some support in specific situations. Providing education, counseling, or materials without asking about firearm ownership was encouraged. Engaging firearm advocates when developing materials may enhance the acceptability of prevention activities.

  14. Large-scale modeling of condition-specific gene regulatory networks by information integration and inference.

    Science.gov (United States)

    Ellwanger, Daniel Christian; Leonhardt, Jörn Florian; Mewes, Hans-Werner

    2014-12-01

    Understanding how regulatory networks globally coordinate the response of a cell to changing conditions, such as perturbations by shifting environments, is an elementary challenge in systems biology which has yet to be met. Genome-wide gene expression measurements are high dimensional as these are reflecting the condition-specific interplay of thousands of cellular components. The integration of prior biological knowledge into the modeling process of systems-wide gene regulation enables the large-scale interpretation of gene expression signals in the context of known regulatory relations. We developed COGERE (http://mips.helmholtz-muenchen.de/cogere), a method for the inference of condition-specific gene regulatory networks in human and mouse. We integrated existing knowledge of regulatory interactions from multiple sources to a comprehensive model of prior information. COGERE infers condition-specific regulation by evaluating the mutual dependency between regulator (transcription factor or miRNA) and target gene expression using prior information. This dependency is scored by the non-parametric, nonlinear correlation coefficient η(2) (eta squared) that is derived by a two-way analysis of variance. We show that COGERE significantly outperforms alternative methods in predicting condition-specific gene regulatory networks on simulated data sets. Furthermore, by inferring the cancer-specific gene regulatory network from the NCI-60 expression study, we demonstrate the utility of COGERE to promote hypothesis-driven clinical research. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  15. 76 FR 329 - Proposed Information Collection; Comment Request; Reporting Requirements for the Ocean Salmon...

    Science.gov (United States)

    2011-01-04

    ... Collection; Comment Request; Reporting Requirements for the Ocean Salmon Fishery Off the Coasts of Washington..., designated regulatory areas in the commercial ocean salmon fishery off the coasts of Washington, Oregon, and... requirements to land salmon within specific time frames and in specific areas may be implemented in the...

  16. Integration of aerial imaging and variable-rate technology for site-specific aerial herbicide application

    Science.gov (United States)

    As remote sensing and variable rate technology are becoming more available for aerial applicators, practical methodologies on effective integration of these technologies are needed for site-specific aerial applications of crop production and protection materials. The objectives of this study were to...

  17. Integrated data management for RODOS

    International Nuclear Information System (INIS)

    Abramowicz, K.; Koschel, A.; Rafat, M.; Wendelgass, R.

    1995-12-01

    The report presents the results of a feasibility study on an integrated data organisation and management in RODOS, the real-time on-line decision support system for off-site nuclear emergency management. The conceptual design of the functional components of the integrated data management are described taking account of the software components and the operation environment of the RODOS system. In particular, the scheme architecture of a database integration manager for accessing and updating a multi-database system is discussed in detail under a variety of database management aspects. Furthermore, the structural design of both a simple knowledge database and a real-time database are described. Finally, some short comments on the benefits and disadvantages of the proposed concept of data integration in RODOS are given. (orig.) [de

  18. 76 FR 22116 - Agency Information Collection Activities: Submission for OMB Review; Comment Request, OMB No...

    Science.gov (United States)

    2011-04-20

    ...-specific issues. Results are also shared with other Federal agencies that lend expertise in specific areas... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID: FEMA-2010-0070.... Comments should be addressed to the Desk Officer for the Department of Homeland Security, Federal Emergency...

  19. Integrating UML, the Q-model and a Multi-Agent Approach in Process Specifications and Behavioural Models of Organisations

    Directory of Open Access Journals (Sweden)

    Raul Savimaa

    2005-08-01

    Full Text Available Efficient estimation and representation of an organisation's behaviour requires specification of business processes and modelling of actors' behaviour. Therefore the existing classical approaches that concentrate only on planned processes are not suitable and an approach that integrates process specifications with behavioural models of actors should be used instead. The present research indicates that a suitable approach should be based on interactive computing. This paper examines the integration of UML diagrams for process specifications, the Q-model specifications for modelling timing criteria of existing and planned processes and a multi-agent approach for simulating non-deterministic behaviour of human actors in an organisation. The corresponding original methodology is introduced and some of its applications as case studies are reviewed.

  20. Medicaid program; premiums and cost sharing. Final rule; delay of effective date and reopening of comment period.

    Science.gov (United States)

    2009-03-27

    This action temporarily delays the effective date of the November 25, 2008 final rule entitled, Medicaid Program; Premiums and Cost Sharing" (73 FR 71828) until December 31, 2009. In addition, this action reopens the comment period on the policies set out in the November 25, 2008 final rule, and specifically solicits comments on the effect of certain provisions of the American Recovery and Reinvestment Act of 2009.

  1. 76 FR 59660 - Proposed Information Collection; Comment Request; National Marine Sanctuary Permits

    Science.gov (United States)

    2011-09-27

    ... Collection; Comment Request; National Marine Sanctuary Permits AGENCY: National Oceanic and Atmospheric... and extension of this information collection. National Marine Sanctuary regulations at 15 CFR part 922 list specific activities that are prohibited in national marine sanctuaries. These regulations also...

  2. The Lorentz integral transform and its inversion

    International Nuclear Information System (INIS)

    Barnea, N.; Efros, V.D.; Leidemann, W.; Orlandini, G.

    2010-01-01

    The Lorentz integral transform method is briefly reviewed. The issue of the inversion of the transform, and in particular its ill-posedness, is addressed. It is pointed out that the mathematical term ill-posed is misleading and merely due to a historical misconception. In this connection standard regularization procedures for the solution of the integral transform problem are presented. In particular a recent one is considered in detail and critical comments on it are provided. In addition a general remark concerning the concept of the Lorentz integral transform as a method with a controlled resolution is made. (author)

  3. Integrating place-specific livelihood and equity outcomes into global assessments of bioenergy deployment

    DEFF Research Database (Denmark)

    Creutzig, Felix; Corbera, Esteve; Bolwig, Simon

    2013-01-01

    -study research focused on first-generation biofuel crops to demonstrate that food, income, land and other assets such as health are key livelihood dimensions that can be impacted by such crops and we highlight how place-specific and global dynamics influence both aggregate and distributional outcomes across......Integrated assessment models suggest that the large-scale deployment of bioenergy could contribute to ambitious climate change mitigation efforts. However, such a shift would intensify the global competition for land, with possible consequences for 1.5 billion smallholder livelihoods...... these livelihood dimensions. We argue that place-specific production models and land tenure regimes mediate livelihood outcomes, which are also in turn affected by global and regional markets and their resulting equilibrium dynamics. The place-specific perspective suggests that distributional consequences...

  4. A resolvase-like protein is requered for the site-specific integration of the temperate lactococcal bacteriophage TP901-1

    DEFF Research Database (Denmark)

    Christiansen, Bettina; Brøndsted, Lone; Vogensen, Finn K.

    1996-01-01

    upstream of attP. The N-terminal 150 to 1180 amino acids of Orf1 showed 38 to 44% similarity to the resolvase group of site-specific integrases, while no similarity to know proteins was found in the C-terminal end. Bacteriophage 'TP901-1 therefore contains a unique integration system that does not resemble...... the Int class of site-specific integrases usually found in temperate bacteriophages. The constructed integration vector, pBC170, integrates into the chromosomal attachment site very efficiently and forms stable transformants with a frequency corresponding to 20% of the transformation efficiency....

  5. Feynman's path integrals and Bohm's particle paths

    International Nuclear Information System (INIS)

    Tumulka, Roderich

    2005-01-01

    Both Bohmian mechanics, a version of quantum mechanics with trajectories, and Feynman's path integral formalism have something to do with particle paths in space and time. The question thus arises how the two ideas relate to each other. In short, the answer is, path integrals provide a re-formulation of Schroedinger's equation, which is half of the defining equations of Bohmian mechanics. I try to give a clear and concise description of the various aspects of the situation. (letters and comments)

  6. Aesthetic emotions goals. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Perlovsky, Leonid

    2015-06-01

    Review by Koelsch et al. [10] presents an interdisciplinary theory of emotions, including a neurobiological emotion theory originating in four core emotional systems. The Quartet Theory (QT) includes specifically human emotions and considers the role of language for emotions. This comment considers questions about how the QT can address aesthetic emotions, what class of emotions they are, and what their function in cognition is. Can QT help defining aesthetic emotions neurally and functionally? Such a definition of aesthetic emotions would be necessary for their scientific exploration, because as widely used today there is no definition, aesthetics is defined through art, and art through aesthetics. Since contents of many art museums are not accepted as art by many artists and admirers of art, it is not clear what should be the subject of aesthetic emotions research.

  7. 76 FR 40918 - Proposed Data Collections Submitted for Public Comment and Recommendations

    Science.gov (United States)

    2011-07-12

    ... technology. Written comments should be received within 60 days of this notice. Proposed Project Validation of... United States has increased the demand for Spanish-language occupational safety and health training... into Spanish rather than developing new materials specifically designed for Latino immigrants. Critics...

  8. Incorporating and evaluating an integrated gender-specific medicine curriculum: a survey study in Dutch GP training

    Science.gov (United States)

    Dielissen, Patrick W; Bottema, Ben JAM; Verdonk, Petra; Lagro-Janssen, Toine LM

    2009-01-01

    Background We recently set standards for gender-specific medicine training as an integrated part of the GP training curriculum. This paper describes the programme and evaluation of this training. Methods The programme is designed for GP registrars throughout the 3-year GP training. The modules emphasize interaction, application, and clinically integrated learning and teaching methods in peer groups. In 2005 - 2008, after completion of each tutorial, GP registrars were asked to fill in a questionnaire on a 5-point Likert scale to assess the programme's methods and content. GP registrars were also asked to identify two learning points related to the programme. Results The teaching programme consists of five 3-hour modules that include gender themes related to and frequently seen by GPs such as in doctor-patient communication and cardiovascular disease. GP registrars evaluated the training course positively. The written learning points suggest that GP registrars have increased their awareness of why attention to gender-specific information is relevant. Conclusion In summary, gender-specific medicine training has been successfully integrated into an existing GP training curriculum. The modules and teaching methods are transferable to other training institutes for postgraduate training. The evaluation of the teaching programme shows a positive impact on GP registrars' gender awareness. PMID:19737396

  9. Incorporating and evaluating an integrated gender-specific medicine curriculum: a survey study in Dutch GP training

    Directory of Open Access Journals (Sweden)

    Lagro-Janssen Toine LM

    2009-09-01

    Full Text Available Abstract Background We recently set standards for gender-specific medicine training as an integrated part of the GP training curriculum. This paper describes the programme and evaluation of this training. Methods The programme is designed for GP registrars throughout the 3-year GP training. The modules emphasize interaction, application, and clinically integrated learning and teaching methods in peer groups. In 2005 - 2008, after completion of each tutorial, GP registrars were asked to fill in a questionnaire on a 5-point Likert scale to assess the programme's methods and content. GP registrars were also asked to identify two learning points related to the programme. Results The teaching programme consists of five 3-hour modules that include gender themes related to and frequently seen by GPs such as in doctor-patient communication and cardiovascular disease. GP registrars evaluated the training course positively. The written learning points suggest that GP registrars have increased their awareness of why attention to gender-specific information is relevant. Conclusion In summary, gender-specific medicine training has been successfully integrated into an existing GP training curriculum. The modules and teaching methods are transferable to other training institutes for postgraduate training. The evaluation of the teaching programme shows a positive impact on GP registrars' gender awareness.

  10. 76 FR 77052 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2011-12-09

    ... 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). The IRS is soliciting comments concerning... requires large banks to change from reserve method of accounting to the specific charge off method of accounting for bad debts. Section 1.585-8 of the regulation contains reporting requirements in cases in which...

  11. 76 FR 68791 - Notice of Availability for Public Comment on the Interagency Ocean Observing Committee Draft...

    Science.gov (United States)

    2011-11-07

    .... This criteria was developed in response to a requirement in the Integrated Coastal Ocean Observation....us . For the public unable to access the internet, printed copies can be requested by contacting the.... Comments may be submitted in writing to the Consortium for Ocean Leadership, Attention: IOOC Support Office...

  12. Head-up and head-down displays integration in automobiles

    Science.gov (United States)

    Betancur, J. Alejandro; Osorio-Gómez, Gilberto; Agudelo, J. David

    2014-06-01

    In automotive industry, the dashboard has been ergonomically developed in order to keep the driver focused on the horizon while driving, but the possibility to access external electronic devices constraints the driver to turn away his face, generating dangerous situations in spite of the short periods of time. Therefore, this work explores the integration of Head-Up Displays and Head-Down Displays in automobiles, proposing configurations that give to drivers the facility to driving focused. In this way, some of the main ergonomic comments about those configurations are proposed; and also, some technical comments regarding the implemented arrangements are given.

  13. Angular distributions of plasma edge velocity and integrated intensity: Update on specific impulse for Ablative Laser Propulsion

    Science.gov (United States)

    Lin, Jun; Pakhomov, Andrew V.

    2005-04-01

    This work concludes our discussion of the image processing technique developed earlier for determination of specific impulse (Isp) for Ablative Laser Propulsion (ALP). The plasma plumes are recorded with a time-resolved intensified charge-coupled device (ICCD) camera. The plasma was formed in vacuum (˜ 3×10-3 Torr) by focusing output pulses of a laser system (100-ps pulsewidth at 532 nm wavelength and ˜35 mJ energy) on surfaces of C (graphite), Al, Si, Fe, Cu, Zn, Sn, and Pb elements. Angular profiles for integrated intensity and plasma expansion velocity were determined for the tested elements. Such profiles were used further for assessment of specific impulse. Specific impulses derived from angular distributions of plasma expansion velocity and integral intensity appeared in excellent agreement with the data derived earlier from force measurements.

  14. Angular distributions of plasma edge velocity and integrated intensity: Update on specific impulse for Ablative Laser Propulsion

    International Nuclear Information System (INIS)

    Lin Jun; Pakhomov, Andrew V.

    2005-01-01

    This work concludes our discussion of the image processing technique developed earlier for determination of specific impulse (Isp) for Ablative Laser Propulsion (ALP). The plasma plumes are recorded with a time-resolved intensified charge-coupled device (ICCD) camera. The plasma was formed in vacuum (∼ 3x10-3 Torr) by focusing output pulses of a laser system (100-ps pulsewidth at 532 nm wavelength and ∼35 mJ energy) on surfaces of C (graphite), Al, Si, Fe, Cu, Zn, Sn, and Pb elements. Angular profiles for integrated intensity and plasma expansion velocity were determined for the tested elements. Such profiles were used further for assessment of specific impulse. Specific impulses derived from angular distributions of plasma expansion velocity and integral intensity appeared in excellent agreement with the data derived earlier from force measurements

  15. 12 CFR 516.130 - Where are comments filed?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Where are comments filed? 516.130 Section 516.130 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY APPLICATION PROCESSING PROCEDURES Comment Procedures § 516.130 Where are comments filed? A commenter must file with the appropriate...

  16. Integrating Iris and Signature Traits for Personal Authentication Using User-SpecificWeighting

    Directory of Open Access Journals (Sweden)

    Serestina Viriri

    2012-03-01

    Full Text Available Biometric systems based on uni-modal traits are characterized by noisy sensor data, restricted degrees of freedom, non-universality and are susceptible to spoof attacks. Multi-modal biometric systems seek to alleviate some of these drawbacks by providing multiple evidences of the same identity. In this paper, a user-score-based weighting technique for integrating the iris and signature traits is presented. This user-specific weighting technique has proved to be an efficient and effective fusion scheme which increases the authentication accuracy rate of multi-modal biometric systems. The weights are used to indicate the importance of matching scores output by each biometrics trait. The experimental results show that our biometric system based on the integration of iris and signature traits achieve a false rejection rate (FRR of 0.08% and a false acceptance rate (FAR of 0.01%.

  17. 14 CFR 11.89 - How much time do I have to submit comments to FAA on a petition for exemption?

    Science.gov (United States)

    2010-01-01

    ... to FAA on a petition for exemption? 11.89 Section 11.89 Aeronautics and Space FEDERAL AVIATION... Petitions for Rulemaking and for Exemption § 11.89 How much time do I have to submit comments to FAA on a petition for exemption? The FAA states the specific time allowed for comments in the Federal Register...

  18. Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase.

    Science.gov (United States)

    Nkrumah, Louis J; Muhle, Rebecca A; Moura, Pedro A; Ghosh, Pallavi; Hatfull, Graham F; Jacobs, William R; Fidock, David A

    2006-08-01

    Here we report an efficient, site-specific system of genetic integration into Plasmodium falciparum malaria parasite chromosomes. This is mediated by mycobacteriophage Bxb1 integrase, which catalyzes recombination between an incoming attP and a chromosomal attB site. We developed P. falciparum lines with the attB site integrated into the glutaredoxin-like cg6 gene. Transfection of these attB(+) lines with a dual-plasmid system, expressing a transgene on an attP-containing plasmid together with a drug resistance gene and the integrase on a separate plasmid, produced recombinant parasites within 2 to 4 weeks that were genetically uniform for single-copy plasmid integration. Integrase-mediated recombination resulted in proper targeting of parasite proteins to intra-erythrocytic compartments, including the apicoplast, a plastid-like organelle. Recombinant attB x attP parasites were genetically stable in the absence of drug and were phenotypically homogeneous. This system can be exploited for rapid genetic integration and complementation analyses at any stage of the P. falciparum life cycle, and it illustrates the utility of Bxb1-based integrative recombination for genetic studies of intracellular eukaryotic organisms.

  19. 75 FR 67666 - Use of Various Winemaking Terms on Wine Labels and in Advertisements; Request for Public Comment

    Science.gov (United States)

    2010-11-03

    ...The Alcohol and Tobacco Tax and Trade Bureau is considering amending the regulations concerning various winemaking terms commonly used on labels and in advertisements to provide consumers with information about the growing or bottling conditions of wine. We invite comments from industry members, consumers, and other interested parties as to whether and to what extent we should propose specific regulatory amendments for further public comment.

  20. Comment on: withdrawal of growth-promoting antibiotics in Europe and its effects in relation to human health

    DEFF Research Database (Denmark)

    Hammerum, Anette Marie; Heuer, Ole Eske; Lester, Camilla H.

    2007-01-01

    In response to a review titled 'Withdrawal of growth-promoting antibiotics in Europe and its effects in relation to human health', published in this Journal by Ian Phillips, we hereby comment on the review. Phillips makes use of data from the Danish Integrated Antimicrobial Resistance Monitoring...

  1. An Exploratory Study into Perceived Task Complexity, Topic Specificity and Usefulness for Integrated Search

    DEFF Research Database (Denmark)

    Ingwersen, Peter; Lioma, Christina; Larsen, Birger

    2012-01-01

    We investigate the relations between user perceptions of work task complexity, topic specificity, and usefulness of retrieved results. 23 academic researchers submitted detailed descriptions of 65 real-life work tasks in the physics domain, and assessed documents retrieved from an integrated...... collection consisting of full text research articles in PDF, abstracts, and bibliographic records [6]. Bibliographic records were found to be more precise than full text PDFs, regardless of task complexity and topic specificity. PDFs were found to be more useful. Overall, for higher task complexity and topic...

  2. Devices and Desires: Integrative Strategy Instruction from a Motivational Perspective.

    Science.gov (United States)

    Vauras, Marja; And Others

    1993-01-01

    This critique of Edwin Ellis's Integrative Strategy Instruction model comments that analyses are needed concerning the mutual social adaptations of differently disposed (cognitively, motivationally, and emotionally) students with learning disabilities and teachers within the social frames of learning environments. (JDD)

  3. 77 FR 24509 - Notice of Proposed Information Collection for Public Comment Emergency Comment Request; Single...

    Science.gov (United States)

    2012-04-24

    ... Information Collection for Public Comment Emergency Comment Request; Single Family Customer Satisfaction... information: Title of Proposal: Single Family Customer Satisfaction Survey. Description of Information... and changes in performance. In addition to the importance HUD management places on the information...

  4. NuSEE: an integrated environment of software specification and V and V for PLC based safety-critical systems

    International Nuclear Information System (INIS)

    Koo, Seo Ryong; Seong, Poong Hyun; Yoo, Jun Beom; Cha, Sung Deok; Youn, Cheong; Han, Hyun Chul

    2006-01-01

    As the use of digital systems becomes more prevalent, adequate techniques for software specification and analysis have become increasingly important in Nuclear Power Plant (NPP) safety-critical systems. Additionally, the importance of software Verification and Validation (V and V) based on adequate specification has received greater emphasis in view of improving software quality. For thorough V and V of safety-critical systems, V and V should be performed throughout the software lifecycle. However, systematic V and V is difficult as it involves many manual-oriented tasks. Tool support is needed in order to more conveniently perform software V and V. In response, we developed four kinds of Computer Aided Software Engineering (CASE) tools to support system specification for a formal-based analysis according to the software lifecycle. In this work, we achieved optimized integration of each tool. The toolset, NuSEE, is an integrated environment for software specification and V and V for PLC based safety-critical systems. In accordance with the software lifecycle, NuSEE consists of NuSISRT for the concept phase, NuSRS for the requirements phase, NuSDS for the design phase and NuSCM for configuration management. It is believed that after further development our integrated environment will be a unique and promising software specification and analysis toolset that will support the entire software lifecycle for the development of PLC based NPP safety-critical systems

  5. Maghreb: from the interconnection of power grids to energetic integration. Energy supply in Maghreb

    International Nuclear Information System (INIS)

    Keramane, Abdelnour

    2015-10-01

    In a first article, the author first comments the levels of electricity production and consumption in Maghreb, and how this production is distributed among different sources in Algeria, Morocco and Tunisia. He comments how electric power utilities in these countries decided to collaborate to create common bodies and to implement an interconnection between their power grids, but also with Libya and Spain. He outlines that the three countries aim at creating a common Maghreb market of electricity and then at being integrated into the European market. The author then discusses the planned evolution of the energy mix, and more particularly the role different energies (hydrocarbons, coal, nuclear, renewable energies) may have in the future. He finally discusses the challenges and issues associated with a passage from collaboration to integration. In the second article, the author proposes an overview of energy supply in Algeria, Morocco and Tunisia. He comments data related to primary energy consumption, to the prevalence of fossil energies, to the marginal share of renewable energies, to energy efficiency, and to carbon footprint. For some of these issues, data are given for 2000 and 2011, for each country, for the three countries together and for the world. The author comments trends, evolutions and perspectives for the different energy resources: hydrocarbons and renewable sources

  6. General guidelines about performance specifications for purchasing equipment for x-ray diagnostics, with comments

    International Nuclear Information System (INIS)

    1995-12-01

    These general guidelines are intended to be used as a basis for what requirements are reasonable from a radiation protection point of view and should be part of the contract in connection with the purchase of equipment for x-ray diagnostics. Technical performance requirements are addressed as well as items like documentation, instructions for use and education and training. The guidelines are also useful for the design of quality assurance programs. In the comments in addition to these guidelines legal aspects are noted, including a list of relevant laws, regulations and directives. Standards, both national and international, within the field are referred to with a short description of their content. 40 refs

  7. General guidelines about performance specifications for purchasing equipment for x-ray diagnostics, with comments

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-01

    These general guidelines are intended to be used as a basis for what requirements are reasonable from a radiation protection point of view and should be part of the contract in connection with the purchase of equipment for x-ray diagnostics. Technical performance requirements are addressed as well as items like documentation, instructions for use and education and training. The guidelines are also useful for the design of quality assurance programs. In the comments in addition to these guidelines legal aspects are noted, including a list of relevant laws, regulations and directives. Standards, both national and international, within the field are referred to with a short description of their content. 40 refs.

  8. 75 FR 77906 - Agency Information Collection Activities: Proposed Collection; Comments Requested: Drug...

    Science.gov (United States)

    2010-12-14

    ... Collection Activities: Proposed Collection; Comments Requested: Drug Questionnaire DEA Form 341 ACTION: 60...: Extension of a currently approved collection. (2) Title of the Form/Collection: Drug Questionnaire (DEA Form... specific questions about their personal history, if any, of illegal drug use. (5) An estimate of the total...

  9. Development and testing of a text-mining approach to analyse patients' comments on their experiences of colorectal cancer care.

    Science.gov (United States)

    Wagland, Richard; Recio-Saucedo, Alejandra; Simon, Michael; Bracher, Michael; Hunt, Katherine; Foster, Claire; Downing, Amy; Glaser, Adam; Corner, Jessica

    2016-08-01

    Quality of cancer care may greatly impact on patients' health-related quality of life (HRQoL). Free-text responses to patient-reported outcome measures (PROMs) provide rich data but analysis is time and resource-intensive. This study developed and tested a learning-based text-mining approach to facilitate analysis of patients' experiences of care and develop an explanatory model illustrating impact on HRQoL. Respondents to a population-based survey of colorectal cancer survivors provided free-text comments regarding their experience of living with and beyond cancer. An existing coding framework was tested and adapted, which informed learning-based text mining of the data. Machine-learning algorithms were trained to identify comments relating to patients' specific experiences of service quality, which were verified by manual qualitative analysis. Comparisons between coded retrieved comments and a HRQoL measure (EQ5D) were explored. The survey response rate was 63.3% (21 802/34 467), of which 25.8% (n=5634) participants provided free-text comments. Of retrieved comments on experiences of care (n=1688), over half (n=1045, 62%) described positive care experiences. Most negative experiences concerned a lack of post-treatment care (n=191, 11% of retrieved comments) and insufficient information concerning self-management strategies (n=135, 8%) or treatment side effects (n=160, 9%). Associations existed between HRQoL scores and coded algorithm-retrieved comments. Analysis indicated that the mechanism by which service quality impacted on HRQoL was the extent to which services prevented or alleviated challenges associated with disease and treatment burdens. Learning-based text mining techniques were found useful and practical tools to identify specific free-text comments within a large dataset, facilitating resource-efficient qualitative analysis. This method should be considered for future PROM analysis to inform policy and practice. Study findings indicated that

  10. Comments on the integrability of the loop-space chiral equations

    International Nuclear Information System (INIS)

    Gu, C.; Wang, L.L.C.

    1980-01-01

    A demonstration is given how the ordinary space chiral equations provide the existence conditions for the infinite number of conserved currents and how these currents are related to the so-called inverse-scattering equations, whose integrability is provided by the original chiral equations. Loop-space chiral equations are introduced. The integrability conditions of the non-local currents in two possible different situations are discussed. In the first case, the generating functions are functionals of the loop alone. The integrability conditions are not satisfied and higher order conserved non-local currents do not exist. In the second case, the generating functions are functionals of the loop as well as a parameter the integrability conditions at a restricted point of the parameter are satisfied, however there is an infinite fold of arbitrariness. It indicates that additional guiding principles are needed in addition to the original loop-space chiral equation in order to uniquely determine the infinite conserved non-local currents as functionals of the loop and the parameter

  11. Sentiment topic mining based on comment tags

    Science.gov (United States)

    Zhang, Daohai; Liu, Xue; Li, Juan; Fan, Mingyue

    2018-03-01

    With the development of e-commerce, various comments based on tags are generated, how to extract valuable information from these comment tags has become an important content of business management decisions. This study takes HUAWEI mobile phone tags as an example using the sentiment analysis and topic LDA mining method. The first step is data preprocessing and classification of comment tag topic mining. And then make the sentiment classification for comment tags. Finally, mine the comments again and analyze the emotional theme distribution under different sentiment classification. The results show that HUAWEI mobile phone has a good user experience in terms of fluency, cost performance, appearance, etc. Meanwhile, it should pay more attention to independent research and development, product design and development. In addition, battery and speed performance should be enhanced.

  12. Patient-specific cardiovascular progenitor cells derived from integration-free induced pluripotent stem cells for vascular tissue regeneration.

    Science.gov (United States)

    Hu, Jiang; Wang, Yongyu; Jiao, Jiao; Liu, Zhongning; Zhao, Chao; Zhou, Zhou; Zhang, Zhanpeng; Forde, Kaitlynn; Wang, Lunchang; Wang, Jiangang; Baylink, David J; Zhang, Xiao-Bing; Gao, Shaorong; Yang, Bo; Chen, Y Eugene; Ma, Peter X

    2015-12-01

    Tissue-engineered blood vessels (TEBVs) are promising in regenerating a live vascular replacement. However, the vascular cell source is limited, and it is crucial to develop a scaffold that accommodates new type of vascular progenitor cells and facilitates in vivo lineage specification of the cells into functional vascular smooth muscle cells (VSMCs) to regenerate vascular tissue. In the present study, integration-free human induced pluripotent stem cells (hiPSCs) were established from patient peripheral blood mononuclear cells through episomal vector nucleofection of reprogramming factors. The established hiPSCs were then induced into mesoderm-originated cardiovascular progenitor cells (CVPCs) with a highly efficient directed lineage specification method. The derived CVPCs were demonstrated to be able to differentiate into functional VSMCs. Subcutaneous implantation of CVPCs seeded on macroporous nanofibrous poly(l-lactide) scaffolds led to in vivo VSMC lineage specification and matrix deposition inside the scaffolds. In summary, we established integration-free patient-specific hiPSCs from peripheral blood mononuclear cells, derived CVPCs through directed lineage specification, and developed an advanced scaffold for these progenitor cells to further differentiate in vivo into VSMCs and regenerate vascular tissue in a subcutaneous implantation model. This study has established an efficient patient-specific approach towards in vivo regeneration of vascular tissue. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Independent peer review panel report on the integrated nonthermal treatment systems study and the comparison of integrated thermal and integrated nonthermal treatment systems for mixed low level waste

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    The US Department of Energy`s (DOE) Office of Environmental Management (EM) Office of Science and Technology (OST) has conducted studies of integrated thermal treatment systems and integrated nonthermal treatment systems (INTS) for treating contact handled, alpha and non-alpha mixed low level radioactive waste (MLLW). The MLLW in the DOE complex consists of a wide variety of organic and inorganic solids and liquids contaminated with radioactive substances. Treatment systems are needed to destroy organic material and stabilize residues prior to land disposal. In May 1996 the Deputy Assistant Secretary for OST appointed an Independent Peer Review Panel to: (1) review and comment on the INTS Study; (2) make recommendations on the most promising thermal and nonthermal treatment systems; (3) make recommendations on research and development necessary to prove the performance of nonthermal and thermal technologies; and (4) review and comment on the preliminary draft of the ITTS/INTS Comparison Report. This report presents the primary conclusions and recommendations based on the review of the INTS study and the comparison report. System selection, overviews, comparisons, cost estimations and sensitivity analyses, and recommended R and D engineering needs are then described and discussed.

  14. Independent peer review panel report on the integrated nonthermal treatment systems study and the comparison of integrated thermal and integrated nonthermal treatment systems for mixed low level waste

    International Nuclear Information System (INIS)

    1996-08-01

    The US Department of Energy's (DOE) Office of Environmental Management (EM) Office of Science and Technology (OST) has conducted studies of integrated thermal treatment systems and integrated nonthermal treatment systems (INTS) for treating contact handled, alpha and non-alpha mixed low level radioactive waste (MLLW). The MLLW in the DOE complex consists of a wide variety of organic and inorganic solids and liquids contaminated with radioactive substances. Treatment systems are needed to destroy organic material and stabilize residues prior to land disposal. In May 1996 the Deputy Assistant Secretary for OST appointed an Independent Peer Review Panel to: (1) review and comment on the INTS Study; (2) make recommendations on the most promising thermal and nonthermal treatment systems; (3) make recommendations on research and development necessary to prove the performance of nonthermal and thermal technologies; and (4) review and comment on the preliminary draft of the ITTS/INTS Comparison Report. This report presents the primary conclusions and recommendations based on the review of the INTS study and the comparison report. System selection, overviews, comparisons, cost estimations and sensitivity analyses, and recommended R and D engineering needs are then described and discussed

  15. 78 FR 52915 - Agency Information Collection Activities; Proposed Collection; Comment Request; Extension

    Science.gov (United States)

    2013-08-27

    ... requires that the disclosures be ``clear and prominent,'' as defined specific to the media used.\\6\\ \\6\\ See... advertising under trade names that resemble the names of legitimate government programs. Given that the... comment does not include any sensitive personal information, like anyone's Social Security number, date of...

  16. 77 FR 53887 - Proposed Data Collections Submitted for Public Comment and Recommendations

    Science.gov (United States)

    2012-09-04

    ... techniques or other forms of information technology. Written comments should be received within 60 days of.... Depending on the specific purpose, data collection methods may be conducted either in-person, by telephone, on paper, or online. Data may be collected in quantitative and/or qualitative forms. Each proposed...

  17. 78 FR 14515 - Extension of Comment Period for Request for Comments on a Patent Small Claims Proceeding in the...

    Science.gov (United States)

    2013-03-06

    ... be sent by email to ip[email protected] . Comments may also be submitted by postal mail addressed to... be submitted by postal mail, the USPTO prefers to receive comments via email. Written comments should be identified in the subject line of the email or postal mailing as ``Patent Small Claims.'' Because...

  18. 75 FR 60767 - Office of the Commissioner; Request for Comments on the Food and Drug Administration Fiscal Year...

    Science.gov (United States)

    2010-10-01

    ... Science and Innovation, (2) Strengthen the Safety and Integrity of the Global Supply Chain, (3) Strengthen... comments to the Division of Dockets Management (HFA- 305), Food and Drug Administration, 5630 Fishers Lane... strengthen the strategic management structure currently in place. For comparison purposes, the current FDA...

  19. Angry and Alone: Demographic Characteristics of Those Who Post to Online Comment Sections

    Directory of Open Access Journals (Sweden)

    Michael Artime

    2016-10-01

    Full Text Available The Internet and social media afford individuals the opportunity to post their thoughts instantaneously and largely without filters. While this has tremendous democratic potential, it also raises questions about the quality of the discourse these technological changes portend. Online comment sections may be a particularly unique form of communication within social media to investigate because of their ubiquitous and often anonymous nature. A longitudinal examination of Pew Center data over the course of 4 years suggests that there are demographic differences between people who post and those who do not post to online comment sections. Specifically, in 2008 and 2010 regression analysis demonstrates there is an increased likelihood of posting among men, the unmarried, and the unemployed. However, the 2012 data tells a different story and suggests the possibility that the nature of comment sections might be changing. The findings have important implications for understanding the character of online discourse as well as the vitriol undergirding the political attitudes of disaffected citizens.

  20. Stylistic Features of Comment in Arabic Blogosphere

    Directory of Open Access Journals (Sweden)

    Gabdulzyamil G. Zaynullin

    2017-11-01

    Full Text Available One of the most important issues in the study of the functioning of the Internet language is the definition of the features of each Internet genre presented in online communication, taking into account the linguocultural features of the language in question. This paper studies the genre of the Internet comments of the Arabic-speaking blogosphere and reveals its stylistic features. The most common goal of the comment is gratitude, followed by praise. We created a corpus of comments from blogs of various subjects, and then conducted the tagging, having identified the group to which we attributed a comment, depending on the subject and the communicative goal. With the help of the Lexico 3 software, the most frequent lexical units were identified, the lexical features of the comments were described, the main one being the widespread use of religionyms, and the relationship between the blog subject and the stylistic characteristics of communication was revealed. The article traces the correlation between the literary and colloquial functional style in the comments, and also draws a conclusion that the comments are of a conversational, informal character. The main devices of expressiveness that are characteristic for both network and pre-network communication were revealed, and the tendency of the analysts to observe in the comments a stable three-part composition (greeting, message, final formula. The influence of traditional Arabic rhetoric, as well as the epistolary genre, was preserved. The results of the paper can be used when studying other genres of Internet communication in Arabic and in comparative studies to create the linguistic software.

  1. Biomass Program 2007 Peer Review - Integrated Biorefinery Platform Summary

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-10-27

    This document discloses the comments provided by a review panel at the U.S. Department of Energy Office of the Biomass Program Peer Review held on November 15-16, 2007 in Baltimore, MD and the Integrated Biorefinery Platform Review held on August 13-15, 2007 in Golden, Colorado.

  2. 77 FR 55470 - Agency Information Collection Activities; Proposed Collection; Comment Request; Reporting and...

    Science.gov (United States)

    2012-09-10

    ... Internet. If you submit an electronic comment, EPA recommends that you include your name and other contact... exemptions for essential uses, critical uses, previously-used material, and material that is transformed... and restrictions on production, imports, and trades and specific exemptions from the phaseout for...

  3. Integrating English for Specific Purposes Courseware into Task-Based Learning in a Context of Preparing for International Trade Fairs

    Science.gov (United States)

    Tsai, Shu-Chiao

    2013-01-01

    This study reports on integrating courseware for participating in international trade fairs into English for specific purposes (ESP) instruction at a technical university in Taiwan. An Information and Communication Technology (ICT) approach combining courseware integration with Task Based Learning (TBL), was adopted. Evaluation of implementing…

  4. Context-specific effects of musical expertise on audiovisual integration

    Science.gov (United States)

    Bishop, Laura; Goebl, Werner

    2014-01-01

    Ensemble musicians exchange auditory and visual signals that can facilitate interpersonal synchronization. Musical expertise improves how precisely auditory and visual signals are perceptually integrated and increases sensitivity to asynchrony between them. Whether expertise improves sensitivity to audiovisual asynchrony in all instrumental contexts or only in those using sound-producing gestures that are within an observer's own motor repertoire is unclear. This study tested the hypothesis that musicians are more sensitive to audiovisual asynchrony in performances featuring their own instrument than in performances featuring other instruments. Short clips were extracted from audio-video recordings of clarinet, piano, and violin performances and presented to highly-skilled clarinetists, pianists, and violinists. Clips either maintained the audiovisual synchrony present in the original recording or were modified so that the video led or lagged behind the audio. Participants indicated whether the audio and video channels in each clip were synchronized. The range of asynchronies most often endorsed as synchronized was assessed as a measure of participants' sensitivities to audiovisual asynchrony. A positive relationship was observed between musical training and sensitivity, with data pooled across stimuli. While participants across expertise groups detected asynchronies most readily in piano stimuli and least readily in violin stimuli, pianists showed significantly better performance for piano stimuli than for either clarinet or violin. These findings suggest that, to an extent, the effects of expertise on audiovisual integration can be instrument-specific; however, the nature of the sound-producing gestures that are observed has a substantial effect on how readily asynchrony is detected as well. PMID:25324819

  5. Novel and successful free comments method for sensory characterization of chocolate ice cream: A comparative study between pivot profile and comment analysis.

    Science.gov (United States)

    Fonseca, Fernando G A; Esmerino, Erick A; Filho, Elson R Tavares; Ferraz, Juliana P; da Cruz, Adriano G; Bolini, Helena M A

    2016-05-01

    Rapid sensory profiling methods have gained space in the sensory evaluation field. Techniques using direct analysis of the terms generated by consumers are considered easy to perform, without specific training requirements, thus improving knowledge about consumer perceptions on various products. This study aimed to determine the sensory profile of different commercial samples of chocolate ice cream, labeled as conventional and light or diet, using the "comment analysis" and "pivot profile" methods, based on consumers' perceptions. In the comment analysis task, consumers responded to 2 separate open questions describing the sensory attributes they liked or disliked in each sample. In the pivot profile method, samples were served in pairs (consisting of a coded sample and pivot), and consumers indicated the higher and lower intensity attributes in the target sample compared with the pivot. We observed that both methods were able to characterize the different chocolate ice cream samples using consumer perception, with high correlation results and configurational similarity (regression vector coefficient=0.917) between them. However, it is worth emphasizing that comment analysis is performed intuitively by consumers, whereas the pivot profile method showed high analytical and discriminative power even using consumers, proving to be a promising technique for routine application when classical descriptive methods cannot be used. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  6. 78 FR 22801 - Request for Comments on Developing a Program To Provide Loan Guarantees to Small- or Medium-Sized...

    Science.gov (United States)

    2013-04-17

    ... manufacturing; manufacture an innovative technology product or an integral component of such a product; or, to... use or production of innovative technologies for manufacturing? Dated: April 10, 2013. Matt Erskine.... SUMMARY: The Economic Development Administration (EDA) seeks public comment on, how to design and...

  7. An integrated in silico approach to design specific inhibitors targeting human poly(a-specific ribonuclease.

    Directory of Open Access Journals (Sweden)

    Dimitrios Vlachakis

    Full Text Available Poly(A-specific ribonuclease (PARN is an exoribonuclease/deadenylase that degrades 3'-end poly(A tails in almost all eukaryotic organisms. Much of the biochemical and structural information on PARN comes from the human enzyme. However, the existence of PARN all along the eukaryotic evolutionary ladder requires further and thorough investigation. Although the complete structure of the full-length human PARN, as well as several aspects of the catalytic mechanism still remain elusive, many previous studies indicate that PARN can be used as potent and promising anti-cancer target. In the present study, we attempt to complement the existing structural information on PARN with in-depth bioinformatics analyses, in order to get a hologram of the molecular evolution of PARNs active site. In an effort to draw an outline, which allows specific drug design targeting PARN, an unequivocally specific platform was designed for the development of selective modulators focusing on the unique structural and catalytic features of the enzyme. Extensive phylogenetic analysis based on all the publicly available genomes indicated a broad distribution for PARN across eukaryotic species and revealed structurally important amino acids which could be assigned as potentially strong contributors to the regulation of the catalytic mechanism of PARN. Based on the above, we propose a comprehensive in silico model for the PARN's catalytic mechanism and moreover, we developed a 3D pharmacophore model, which was subsequently used for the introduction of DNP-poly(A amphipathic substrate analog as a potential inhibitor of PARN. Indeed, biochemical analysis revealed that DNP-poly(A inhibits PARN competitively. Our approach provides an efficient integrated platform for the rational design of pharmacophore models as well as novel modulators of PARN with therapeutic potential.

  8. Comments on "A closed-form solution to Tensor voting: theory and applications"

    OpenAIRE

    Maggiori, Emmanuel; Lotito, Pablo Andres; Manterola, Hugo Luis; del Fresno, Mariana

    2017-01-01

    We comment on a paper that describes a closed-form formulation to Tensor Voting, a technique to perceptually group clouds of points, usually applied to infer features in images. The authors proved an analytic solution to the technique, a highly relevant contribution considering that the original formulation required numerical integration, a time-consuming task. Their work constitutes the first closed-form expression for the Tensor Voting framework. In this work we first observe that the propo...

  9. Text mining analysis of public comments regarding high-level radioactive waste disposal

    International Nuclear Information System (INIS)

    Kugo, Akihide; Yoshikawa, Hidekazu; Shimoda, Hiroshi; Wakabayashi, Yasunaga

    2005-01-01

    In order to narrow the risk perception gap as seen in social investigations between the general public and people who are involved in nuclear industry, public comments on high-level radioactive waste (HLW) disposal have been conducted to find the significant talking points with the general public for constructing an effective risk communication model of social risk information regarding HLW disposal. Text mining was introduced to examine public comments to identify the core public interest underlying the comments. The utilized test mining method is to cluster specific groups of words with negative meanings and then to analyze public understanding by employing text structural analysis to extract words from subjective expressions. Using these procedures, it was found that the public does not trust the nuclear fuel cycle promotion policy and shows signs of anxiety about the long-lasting technological reliability of waste storage. To develop effective social risk communication of HLW issues, these findings are expected to help experts in the nuclear industry to communicate with the general public more effectively to obtain their trust. (author)

  10. Do Online Comments Influence the Public's Attitudes Toward an Organization? Effects of Online Comments Based on Individuals' Prior Attitudes.

    Science.gov (United States)

    Sung, Kang Hoon; Lee, Moon J

    2015-01-01

    The authors investigated the effects of reading different types of online comments about a company on people's attitude change based on individual's prior attitude toward the company. Based on Social Judgment Theory, several hypotheses were tested. The results showed that the effects of online comments interact with individuals' prior attitudes toward a corporation. People with a strong negative attitude toward a corporation were less influenced by other's online comments than people with a neutral attitude in general. However, people with a prior negative attitude were more affected by refutational two-sided comments than one-sided comments. The results suggest that the effects of user generated content should be studied in a holistic manner, not only by investigating the effects of online content itself, but also by examining how others' responses to the content shape or change individuals' attitudes based on their prior attitudes.

  11. The potential of the Internet for music perception research: A comment on lab-based versus Web-based studies

    NARCIS (Netherlands)

    Honing, H.; Ladinig, O.

    2008-01-01

    While the discussion on the integrity of data obtained from Web-delivered experiments is mainly about issues of method and control (Mehler, 1999; McGraw et al., 2000; Auditory, 2007), this comment stresses the potential that Web-based experiments might have for studies in music perception. It is

  12. Joint analyses of open comments and quantitative data: Added value in a job satisfaction survey of hospital professionals.

    Directory of Open Access Journals (Sweden)

    Ingrid Gilles

    Full Text Available To obtain a comprehensive understanding of the job opinions of hospital professionals by conducting qualitative analyses of the open comments included in a job satisfaction survey and combining these results with the quantitative results.A cross-sectional survey targeting all Lausanne University Hospital professionals was performed in the fall of 2013.The survey considered ten job satisfaction dimensions (e.g. self-fulfilment, workload, management, work-related burnout, organisational commitment, intent to stay and included an open comment section. Computer-assisted qualitative analyses were conducted on these comments. Satisfaction rates on the included dimensions and professional groups were entered as predictive variables in the qualitative analyses.Of 10 838 hospital professionals, 4978 participated in the survey and 1067 provided open comments. Data from 1045 respondents with usable comments constituted the analytic sample (133 physicians, 393 nurses, 135 laboratory technicians, 247 administrative staff, including researchers, 67 logistic staff, 44 psycho-social workers, and 26 unspecified.Almost a third of the comments addressed scheduling issues, mostly related to problems and exhaustion linked to shifts, work-life balance, and difficulties with colleagues' absences and the consequences for quality of care and patient safety. The other two-thirds related to classic themes included in job satisfaction surveys. Although some comments were provided equally by all professional groups, others were group specific: work and hierarchy pressures for physicians, healthcare quality and patient safety for nurses, skill recognition for administrative staff. Overall, respondents' comments were consistent with their job satisfaction ratings.Open comment analysis provides a comprehensive understanding of hospital professionals' job experiences, allowing better consideration of quality initiatives that match the needs of professionals with reality.

  13. Joint analyses of open comments and quantitative data: Added value in a job satisfaction survey of hospital professionals.

    Science.gov (United States)

    Gilles, Ingrid; Mayer, Mauro; Courvoisier, Nelly; Peytremann-Bridevaux, Isabelle

    2017-01-01

    To obtain a comprehensive understanding of the job opinions of hospital professionals by conducting qualitative analyses of the open comments included in a job satisfaction survey and combining these results with the quantitative results. A cross-sectional survey targeting all Lausanne University Hospital professionals was performed in the fall of 2013. The survey considered ten job satisfaction dimensions (e.g. self-fulfilment, workload, management, work-related burnout, organisational commitment, intent to stay) and included an open comment section. Computer-assisted qualitative analyses were conducted on these comments. Satisfaction rates on the included dimensions and professional groups were entered as predictive variables in the qualitative analyses. Of 10 838 hospital professionals, 4978 participated in the survey and 1067 provided open comments. Data from 1045 respondents with usable comments constituted the analytic sample (133 physicians, 393 nurses, 135 laboratory technicians, 247 administrative staff, including researchers, 67 logistic staff, 44 psycho-social workers, and 26 unspecified). Almost a third of the comments addressed scheduling issues, mostly related to problems and exhaustion linked to shifts, work-life balance, and difficulties with colleagues' absences and the consequences for quality of care and patient safety. The other two-thirds related to classic themes included in job satisfaction surveys. Although some comments were provided equally by all professional groups, others were group specific: work and hierarchy pressures for physicians, healthcare quality and patient safety for nurses, skill recognition for administrative staff. Overall, respondents' comments were consistent with their job satisfaction ratings. Open comment analysis provides a comprehensive understanding of hospital professionals' job experiences, allowing better consideration of quality initiatives that match the needs of professionals with reality.

  14. 77 FR 67678 - Content Specifications and Shielding Evaluations for Type B Transportation Packages

    Science.gov (United States)

    2012-11-13

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0270] Content Specifications and Shielding Evaluations for... Commission) is issuing for public comment Draft Regulatory Issue Summary (RIS) 2012-XX, ``Content... Material,'' for the review of content specifications and shielding evaluations included in the Certificates...

  15. 75 FR 65625 - Agency Information Collection Activities; Proposed Collection; Comment Request; Hazardous Waste...

    Science.gov (United States)

    2010-10-26

    ... Activities; Proposed Collection; Comment Request; Hazardous Waste Specific Unit Requirements, and Special Waste Processes and Types, EPA ICR Number 1572.08, OMB Control Number 2050-0050 AGENCY: Environmental..., and Special Waste Processes and Types. ICR numbers: EPA ICR No. 1572.08, OMB Control No. 2050-0050...

  16. 49 CFR 1110.5 - Consideration of comments received.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Consideration of comments received. 1110.5 Section 1110.5 Transportation Other Regulations Relating to Transportation (Continued) SURFACE TRANSPORTATION... PROCEEDINGS § 1110.5 Consideration of comments received. All timely comments will be considered before final...

  17. Are Final Comments in Web Survey Panels Associated with Next-Wave Attrition?

    Directory of Open Access Journals (Sweden)

    Cynthia McLauchlan

    2016-12-01

    Full Text Available Near the end of a web survey respondents are often asked whether they have further comments. Such final comments are usually ignored, in part because open-ended questions are challenging to analyse. We explored whether final comments are associated with next-wave attrition in survey panels. We categorized a random sample of final comments in the Longitudinal Studies for the Social Sciences (LISS panel and Dutch Immigrant panel into one of eight categories (neutral, positive, six subcategories of negative and regressed the indicator of next-wave attrition on comment length, comment category and socio-demographic variables. In the Immigrant panel we found shorter final comments (55 words with decreased next-wave attrition relative to making no comment. Comments about unclear survey questions quadruple the odds of attrition and “other” (uncategorized negative comments almost double the odds of attrition. In the LISS panel, making a comment (vs. not and comment length are not associated with attrition. However, when specifying individual comment categories, neutral comments are associated with half the odds of attrition relative to not making a comment.

  18. 78 FR 75947 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Welding...

    Science.gov (United States)

    2013-12-13

    ... for OMB Review; Comment Request; Welding, Cutting, and Brazing Standard ACTION: Notice. SUMMARY: The... information collection request (ICR) titled, ``Welding, Cutting, and Brazing Standard,'' to the Office of... the Welding, Cutting, and Brazing Standard, regulations 29 CFR part 1910, subpart Q. More specifically...

  19. Specification and Generation of Adapters for System Integration

    NARCIS (Netherlands)

    Mooij, A.J.; Voorhoeve, M.

    2013-01-01

    Large systems-of-systems are developed by integrating several smaller systems that have been developed independently. System integration often requires adaptation mechanisms for bridging any technical incompatibilities between the systems. In order to develop adapters in a faster way, we study ways

  20. IRSN's opinion on the 300-AQ-061 specification for packaging intermediate-activity effluents by vitrification

    International Nuclear Information System (INIS)

    2009-07-01

    This document comments a specification submitted by AREVA for the vitrification of rinsing effluents produced by shutting-down operations of the UP2-400 plant. After a description of the context created by the dismantling of this plant (decontamination operations, project of packaging effluents in an alumino-borosilicate matrix, contaminated compounds), this report discusses the assessment of the 300 AQ 61 specification proposed by AREVA. The quality of the process is related to the incorporation and to the homogeneous distribution of the radioactive material in a vitreous network. The report comments the specification with respect to the content assessed values for the different compounds and species, and with respect to the vitrification process parameters

  1. Human comment dynamics in on-line social systems

    Science.gov (United States)

    Wu, Ye; Zhou, Changsong; Chen, Maoying; Xiao, Jinghua; Kurths, Jürgen

    2010-12-01

    Human comment is studied using data from ‘tianya’ which is one of the most popular on-line social systems in China. We found that the time interval between two consecutive comments on the same topic, called inter-event time, follows a power-law distribution. This result shows that there is no characteristic decay time on a topic. It allows for very long periods without comments that separate bursts of intensive comments. Furthermore, the frequency of a different ID commenting on a topic also follows a power-law distribution. It indicates that there are some “hubs” in the topic who lead the direction of the public opinion. Based on the personal comments habit, a model is introduced to explain these phenomena. The numerical simulations of the model fit well with the empirical results. Our findings are helpful for discovering regular patterns of human behavior in on-line society and the evolution of the public opinion on the virtual as well as real society.

  2. Application-specific integrated circuit design for a typical pressurized water reactor pressure channel trip

    International Nuclear Information System (INIS)

    Battle, R.E.; Manges, W.W.; Emery, M.S.; Vendermolen, R.I.; Bhatt, S.

    1994-01-01

    This article discusses the use of application-specific integrated circuits (ASICs) in nuclear plant safety systems. ASICs have certain advantages over software-based systems because they can be simple enough to be thoroughly tested, and they can be tailored to replace existing equipment. An architecture to replace a pressurized water reactor pressure channel trip is presented. Methods of implementing digital algorithms are also discussed

  3. Does Mind Wandering Reflect Executive Function or Executive Failure? Comment on Smallwood and Schooler (2006) and Watkins (2008)

    Science.gov (United States)

    McVay, Jennifer C.; Kane, Michael J.

    2010-01-01

    In this comment, we contrast different conceptions of mind wandering that were presented in 2 recent theoretical reviews: Smallwood and Schooler (2006) and Watkins (2008). We also introduce a new perspective on the role of executive control in mind wandering by integrating empirical evidence presented in Smallwood and Schooler with 2 theoretical…

  4. 77 FR 36330 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

    Science.gov (United States)

    2012-06-18

    ... a specific investigation. That information is then provided to the FAA decision making authority to... the quality of the collected information. The agency will summarize and/or include your comments in... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Agency Information Collection...

  5. 77 FR 18804 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

    Science.gov (United States)

    2012-03-28

    ... Budget (OMB) for review and approval. This is a request to renew an existing approved collection. The ICR... and without change, unless the comment contains copyrighted material, confidential business... attitudes, beliefs, motivations and feelings regarding specific issues and will provide invaluable...

  6. Detecting spam comments on Indonesia’s Instagram posts

    Science.gov (United States)

    Septiandri, Ali Akbar; Wibisono, Okiriza

    2017-01-01

    In this paper we experimented with several feature sets for detecting spam comments in social media contents authored by Indonesian public figures. We define spam comments as comments which have promotional purposes (e.g. referring other users to products and services) and thus not related to the content to which the comments are posted. Three sets of features are evaluated for detecting spams: (1) hand-engineered features such as comment length, number of capital letters, and number of emojis, (2) keyword features such as whether the comment contains advertising words or product-related words, and (3) text features, namely, bag-of-words, TF-IDF, and fastText embeddings, each combined with latent semantic analysis. With 24,000 manually-annotated comments scraped from Instagram posts authored by more than 100 Indonesian public figures, we compared the performance of these feature sets and their combinations using 3 popular classification algorithms: Na¨ıve Bayes, SVM, and XGBoost. We find that using all three feature sets (with fastText embedding for the text features) gave the best F 1-score of 0.9601 on a holdout dataset. More interestingly, fastText embedding combined with hand-engineered features (i.e. without keyword features) yield similar F 1-score of 0.9523, and McNemar’s test failed to reject the hypothesis that the two results are not significantly different. This result is important as keyword features are largely dependent on the dataset and may not be as generalisable as the other feature sets when applied to new data. For future work, we hope to collect bigger and more diverse dataset of Indonesian spam comments, improve our model’s performance and generalisability, and publish a programming package for others to reliably detect spam comments.

  7. 75 FR 22577 - Proposed Notice and Comment Policy Version 2.0

    Science.gov (United States)

    2010-04-29

    ... Comment Policy 2.0. SUMMARY: The U.S. Election Assistance Commission (EAC) seeks public comment on the... notice for a period of public comment on all policies being considered for adoption by the EAC, that are.... EDT on June 1, 2010. Comments: Public comments are invited on the information contained in the policy...

  8. Theoretical Orientation and Psychotherapy Integration: Comment on Poznanski and McLennan.

    Science.gov (United States)

    Arnkoff, Diane B.

    1995-01-01

    Considers Poznanski and McLennan's (1995) discussion and proposals for measurement of theoretical orientation in light of recent interest in psychotherapy integration. Presents suggestions to allow better assessment of the orientation of counselors who espouse integrative theories or technical eclecticism. (JPS)

  9. 75 FR 57506 - Summary of Comments

    Science.gov (United States)

    2010-09-21

    ... on the environmental impact of the good or service produced or the production process used. Several... comment noted environmental impacts in this category, i.e., using fresh versus packaged food, reduces... activities in this category. One comment recommended moving nuclear energy to category 1, renewable energy...

  10. 78 FR 78341 - Extension of Comment Period for Public Comments on Department of Commerce Green Paper, Copyright...

    Science.gov (United States)

    2013-12-26

    ... policy issues critical to economic growth, job creation, and cultural development that were identified in...-meeting comments. DATES: To be ensured of consideration, post-meeting comments are due on or before... confidential business information or otherwise sensitive or protected information. The Task Force will accept...

  11. Responses to comments received on the draft final report of the Secretary of Energy Advisory Board Task Force on Radioactive Waste Management

    International Nuclear Information System (INIS)

    1994-01-01

    The Task Force solicited comments on its Draft Final Report from a variety of sources. Letters were sent to over 400 individuals who had expressed interest in the interest in the Department's radioactive waste, management programs, a notice was placed in the Federal Register, the morning session of the January 1993 meeting of the full Secretary of Energy Advisory Board was given over to discussion of the draft, and Task Force members and staff presented the effort at several professional meetings. Altogether 32 written comments were received. They are reproduced here, followed in each case by the Task Force's response to specific suggestions made to improve the draft. (The panel did not respond to comments that simply reflected policy preferences or that praised the group's effort.) With one exception, those specific suggestions are highlighted and given a letter designation from open-quotes Aclose quotes to open-quotes Zclose quotes. The Task Force's responses, written in the Fall 1993, are labeled in a like manner. For the one exception, a comments submitted by Judy Treichel, the Task Force's response is printed on copies of her annotated pages

  12. Responses to comments received on the draft final report of the Secretary of Energy Advisory Board Task Force on Radioactive Waste Management

    Energy Technology Data Exchange (ETDEWEB)

    1994-10-01

    The Task Force solicited comments on its Draft Final Report from a variety of sources. Letters were sent to over 400 individuals who had expressed interest in the interest in the Department`s radioactive waste, management programs, a notice was placed in the Federal Register, the morning session of the January 1993 meeting of the full Secretary of Energy Advisory Board was given over to discussion of the draft, and Task Force members and staff presented the effort at several professional meetings. Altogether 32 written comments were received. They are reproduced here, followed in each case by the Task Force`s response to specific suggestions made to improve the draft. (The panel did not respond to comments that simply reflected policy preferences or that praised the group`s effort.) With one exception, those specific suggestions are highlighted and given a letter designation from {open_quotes}A{close_quotes} to {open_quotes}Z{close_quotes}. The Task Force`s responses, written in the Fall 1993, are labeled in a like manner. For the one exception, a comments submitted by Judy Treichel, the Task Force`s response is printed on copies of her annotated pages.

  13. Online News Sites and Journalism 2.0: Reader Comments on Al Jazeera Arabic

    Directory of Open Access Journals (Sweden)

    Muhammad M. Abdul-Mageed

    2008-12-01

    Full Text Available The current paper investigates reader commenting on news sites as one facet of journalism 2.0. Specifically, the themes, frequency, and regional coverage of readers’ comments—and in general, their activity levels and distribution—are considered, with a goal to increase knowledge of convergent media and computer-mediated communication (CMC, as well as shed light on the interactivity strategies adopted by influential news producers. The corpus is collected from the Arabic news site of the controversial Middle East-based, bilingual network Al Jazeera. Reader commenting was found to be a regular occurrence on the site but distributed unevenly across stories. The stories focused mostly on themes related to military and political violence, politics, and foreign relations, and covered events related to the Arab world more than other regions. Also, patterns of commenting varied according to day of the week and position of the story on the web page. Overall, these findings suggest that citizen journalism—journalism is performed by lay persons—on Al Jazeera tends to be shaped by the coverage and layout of the news site. Moreover, citizen participation in online news sites such as Al Jazeera is still far from ideal, in that commenters are given neither the access nor the facilitation to use modalities other than written text. These limitations are critiqued in light of contemporary discourses about media convergence and journalism 2.0.

  14. 36 CFR 801.4 - Council comments.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Council comments. 801.4 Section 801.4 Parks, Forests, and Public Property ADVISORY COUNCIL ON HISTORIC PRESERVATION HISTORIC PRESERVATION REQUIREMENTS OF THE URBAN DEVELOPMENT ACTION GRANT PROGRAM § 801.4 Council comments. The following...

  15. Reactor protection system design using application specific integrated circuits

    International Nuclear Information System (INIS)

    Battle, R.E.; Bryan, W.L.; Kisner, R.A.; Wilson, T.L. Jr.

    1992-01-01

    Implementing reactor protection systems (RPS) or other engineering safeguard systems with application specific integrated circuits (ASICs) offers significant advantages over conventional analog or software based RPSs. Conventional analog RPSs suffer from setpoints drifts and large numbers of discrete analog electronics, hardware logic, and relays which reduce reliability because of the large number of potential failures of components or interconnections. To resolve problems associated with conventional discrete RPSs and proposed software based RPS systems, a hybrid analog and digital RPS system implemented with custom ASICs is proposed. The actual design of the ASIC RPS resembles a software based RPS but the programmable software portion of each channel is implemented in a fixed digital logic design including any input variable computations. Set point drifts are zero as in proposed software systems, but the verification and validation of the computations is made easier since the computational logic an be exhaustively tested. The functionality is assured fixed because there can be no future changes to the ASIC without redesign and fabrication. Subtle error conditions caused by out of order evaluation or time dependent evaluation of system variables against protection criteria are eliminated by implementing all evaluation computations in parallel for simultaneous results. On- chip redundancy within each RPS channel and continuous self-testing of all channels provided enhanced assurance that a particular channel is available and faults are identified as soon as possible for corrective actions. The use of highly integrated ASICs to implement channel electronics rather than the use of discrete electronics greatly reduces the total number of components and interconnections in the RPS to further increase system reliability. A prototype ASIC RPS channel design and the design environment used for ASIC RPS systems design is discussed

  16. Operational Excellence through Schedule Optimization and Production Simulation of Application Specific Integrated Circuits.

    Energy Technology Data Exchange (ETDEWEB)

    Flory, John Andrew [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Padilla, Denise D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gauthier, John H. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Zwerneman, April Marie [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Miller, Steven P [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-05-01

    Upcoming weapon programs require an aggressive increase in Application Specific Integrated Circuit (ASIC) production at Sandia National Laboratories (SNL). SNL has developed unique modeling and optimization tools that have been instrumental in improving ASIC production productivity and efficiency, identifying optimal operational and tactical execution plans under resource constraints, and providing confidence in successful mission execution. With ten products and unprecedented levels of demand, a single set of shared resources, highly variable processes, and the need for external supplier task synchronization, scheduling is an integral part of successful manufacturing. The scheduler uses an iterative multi-objective genetic algorithm and a multi-dimensional performance evaluator. Schedule feasibility is assessed using a discrete event simulation (DES) that incorporates operational uncertainty, variability, and resource availability. The tools provide rapid scenario assessments and responses to variances in the operational environment, and have been used to inform major equipment investments and workforce planning decisions in multiple SNL facilities.

  17. Site-specific integration of CAR gene into Jurkat T cells with a linear close-ended AAV-based DNA vector for CAR-T engineering.

    Science.gov (United States)

    Zhang, Yun; Liu, Xiaomei; Zhang, Jinju; Zhang, Chun

    2016-09-01

    To develop a site-specific integration strategy for CAR-T engineering by using a non-viral vector dependent on adeno-associated viral (AAV) genome, which tends to be integrated into AAVS1 site with the help of its Rep proteins. AAV-dependent vectors were produced in Sf9 cells. Structural analyses revealed the vector as covalently close-ended, linear duplex molecules, which was termed "CELiD" DNA. A plasmid CMV-Rep was constructed to express the integrases Rep78 and Rep68. Jurkat cells were co-electroporated with "CELiD" DNA and plasmid CMV-Rep in order to specifically integrate CAR gene into AAVS1 site. We examined 71 stably transfected Jurkat clones by nested PCR, sequencing and southern blotting, of which 30 clones bore CAR gene within AAVS1 site. The site-specific integration efficiency was nearly 42.2 %. The AAV-dependent vector preferentially integrated CAR into AAVS1 site, which could be further used in human T cell modification and enhance the security of CAR-T therapy.

  18. 76 FR 44048 - Agency Information Collection Activities: Comment Request

    Science.gov (United States)

    2011-07-22

    .../webcaspar . A public release file is also made available on the World Wide Web. Comment: On May 11, 2011 we... NATIONAL SCIENCE FOUNDATION Agency Information Collection Activities: Comment Request AGENCY: National Science Foundation. ACTION: Submission for OMB review; Request for Comments. SUMMARY: The National...

  19. Perfect discretization of reparametrization invariant path integrals

    International Nuclear Information System (INIS)

    Bahr, Benjamin; Dittrich, Bianca; Steinhaus, Sebastian

    2011-01-01

    To obtain a well-defined path integral one often employs discretizations. In the case of gravity and reparametrization-invariant systems, the latter of which we consider here as a toy example, discretizations generically break diffeomorphism and reparametrization symmetry, respectively. This has severe implications, as these symmetries determine the dynamics of the corresponding system. Indeed we will show that a discretized path integral with reparametrization-invariance is necessarily also discretization independent and therefore uniquely determined by the corresponding continuum quantum mechanical propagator. We use this insight to develop an iterative method for constructing such a discretized path integral, akin to a Wilsonian RG flow. This allows us to address the problem of discretization ambiguities and of an anomaly-free path integral measure for such systems. The latter is needed to obtain a path integral, that can act as a projector onto the physical states, satisfying the quantum constraints. We will comment on implications for discrete quantum gravity models, such as spin foams.

  20. Perfect discretization of reparametrization invariant path integrals

    Science.gov (United States)

    Bahr, Benjamin; Dittrich, Bianca; Steinhaus, Sebastian

    2011-05-01

    To obtain a well-defined path integral one often employs discretizations. In the case of gravity and reparametrization-invariant systems, the latter of which we consider here as a toy example, discretizations generically break diffeomorphism and reparametrization symmetry, respectively. This has severe implications, as these symmetries determine the dynamics of the corresponding system. Indeed we will show that a discretized path integral with reparametrization-invariance is necessarily also discretization independent and therefore uniquely determined by the corresponding continuum quantum mechanical propagator. We use this insight to develop an iterative method for constructing such a discretized path integral, akin to a Wilsonian RG flow. This allows us to address the problem of discretization ambiguities and of an anomaly-free path integral measure for such systems. The latter is needed to obtain a path integral, that can act as a projector onto the physical states, satisfying the quantum constraints. We will comment on implications for discrete quantum gravity models, such as spin foams.

  1. 77 FR 23238 - Guidelines for Home Energy Professionals: Standard Work Specifications for Single Family Energy...

    Science.gov (United States)

    2012-04-18

    ...: Comments on the Guidelines for Home Energy Professionals: Standard Work Specifications for Single Family... DEPARTMENT OF ENERGY Office of Energy Efficiency and Renewable Energy Guidelines for Home Energy Professionals: Standard Work Specifications for Single Family Energy Upgrades AGENCY: Office of Energy...

  2. Integration of Descending Command Systems for the Generation of Context-Specific Locomotor Behaviors

    Directory of Open Access Journals (Sweden)

    Linda H. Kim

    2017-10-01

    Full Text Available Over the past decade there has been a renaissance in our understanding of spinal cord circuits; new technologies are beginning to provide key insights into descending circuits which project onto spinal cord central pattern generators. By integrating work from both the locomotor and animal behavioral fields, we can now examine context-specific control of locomotion, with an emphasis on descending modulation arising from various regions of the brainstem. Here we examine approach and avoidance behaviors and the circuits that lead to the production and arrest of locomotion.

  3. First Steps Towards AN Integrated Citygml-Based 3d Model of Vienna

    Science.gov (United States)

    Agugiaro, G.

    2016-06-01

    This paper presents and discusses the results regarding the initial steps (selection, analysis, preparation and eventual integration of a number of datasets) for the creation of an integrated, semantic, three-dimensional, and CityGML-based virtual model of the city of Vienna. CityGML is an international standard conceived specifically as information and data model for semantic city models at urban and territorial scale. It is being adopted by more and more cities all over the world. The work described in this paper is embedded within the European Marie-Curie ITN project "Ci-nergy, Smart cities with sustainable energy systems", which aims, among the rest, at developing urban decision making and operational optimisation software tools to minimise non-renewable energy use in cities. Given the scope and scale of the project, it is therefore vital to set up a common, unique and spatio-semantically coherent urban model to be used as information hub for all applications being developed. This paper reports about the experiences done so far, it describes the test area and the available data sources, it shows and exemplifies the data integration issues, the strategies developed to solve them in order to obtain the integrated 3D city model. The first results as well as some comments about their quality and limitations are presented, together with the discussion regarding the next steps and some planned improvements.

  4. Integral transforms and their applications

    CERN Document Server

    Debnath, Lokenath

    2006-01-01

    Keeping the style, content, and focus that made the first edition a bestseller, Integral Transforms and their Applications, Second Edition stresses the development of analytical skills rather than the importance of more abstract formulation. The authors provide a working knowledge of the analytical methods required in pure and applied mathematics, physics, and engineering. The second edition includes many new applications, exercises, comments, and observations with some sections entirely rewritten. It contains more than 500 worked examples and exercises with answers as well as hints to selecte

  5. PENGEMBANGAN SUBJECT SPECIFIC PEDAGOGY (SSP IPA TERPADU UNTUK MENINGKATKAN HASIL BELAJAR SISWA

    Directory of Open Access Journals (Sweden)

    Fitri Yuliawati

    2016-05-01

    Full Text Available Background of this research is the analysis of the results of interviews some junior secondary schools in Yogyakarta and the conclusion that teachers do not use an integrated science teaching and teachers still find difficulties in the application of learning science in an integrated manner. It can be influenced by several factors, such as the lack of reference used by teachers in presenting the material Integrated Science relevantly, most of science teachers are from educational background of chemistry, physics, and biology instead of science education, so that teachers find difficulties to create an integrated learning of science. In addition, teachers feel difficulty in determining the depth of the material, limits of integration in integrated science teaching, and did not know the concept of integrated science teaching. This research is a development research. Learning tools developed included : student books, lesson plans, student activity sheets and evaluation tools. The development of the learning which is done in this study use the models of 4D development which includes the step of Define (definition which at this stage conducted a needs analysis. Design : it is the stage of Subject Specific Pedagogy (SSP software design. Development, it is the stage of development after the draft was made followed by a learning device validation by experts. This stage is also conducted to seek input from all the responses, reactions and comments from teachers, students, and observers so that it can be used for further improvement of science teaching later. The Disseminate, it is the stage of field tests are widely but not done. Data collection instruments used in this study include : test items and questionnaire. The conclusion of this development research are as follows : the results of the validation SSP integrated science by learning tools expert, material experts and media experts indicate the category of Very Good (SB so that SSP integrated

  6. Predicting the volume of comments on online news stories

    NARCIS (Netherlands)

    Tsagkias, M.; Weerkamp, W.; de Rijke, M.; Cheung, D.; Song, I.-Y.; Chu, W.; Hu, X.; Lin, J.; Li, J.; Peng, Z.

    2009-01-01

    On-line news agents provide commenting facilities for readers to express their views with regard to news stories. The number of user supplied comments on a news article may be indicative of its importance or impact. We report on exploratory work that predicts the comment volume of news articles

  7. The Continuing Evolution of Languages for Specific Purposes

    Science.gov (United States)

    Grosse, Christine Uber; Voght, Geoffrey M.

    2012-01-01

    This overview to "The Modern Language Journal"'s Focus Issue on Languages for Specific Purposes (LSP) takes a fresh look at issues examined in a 1991 article by Grosse and Voght. Reflecting on change drivers and growth in LSP, the authors comment on current challenges to the field and future research needs. Their remarks are based on new insights…

  8. 75 FR 38809 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

    Science.gov (United States)

    2010-07-06

    ... Management (OEM). EPA has established an effectiveness threshold for listing dispersants (40 CFR 300.920(a)(2... information collection and its estimated burden and cost. DATES: Additional comments may be submitted on or... manufacturer conduct specific toxicity and effectiveness tests and submit the corresponding technical product...

  9. Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library

    Directory of Open Access Journals (Sweden)

    Eddy Edward M

    2007-07-01

    Full Text Available Abstract Background The primary regulator of spermatogenesis, a highly ordered and tightly regulated developmental process, is an intrinsic genetic program involving male germ cell-specific genes. Results We analyzed the mouse spermatocyte UniGene library containing 2155 gene-oriented transcript clusters. We predict that 11% of these genes are testis-specific and systematically identified 24 authentic genes specifically and abundantly expressed in the testis via in silico and in vitro approaches. Northern blot analysis disclosed various transcript characteristics, such as expression level, size and the presence of isoform. Expression analysis revealed developmentally regulated and stage-specific expression patterns in all of the genes. We further analyzed the genes at the protein and cellular levels. Transfection assays performed using GC-2 cells provided information on the cellular characteristics of the gene products. In addition, antibodies were generated against proteins encoded by some of the genes to facilitate their identification and characterization in spermatogenic cells and sperm. Our data suggest that a number of the gene products are implicated in transcriptional regulation, nuclear integrity, sperm structure and motility, and fertilization. In particular, we found for the first time that Mm.333010, predicted to contain a trypsin-like serine protease domain, is a sperm acrosomal protein. Conclusion We identify 24 authentic genes with spermatogenic cell-specific expression, and provide comprehensive information about the genes. Our findings establish a new basis for future investigation into molecular mechanisms underlying male reproduction.

  10. NCPA No. 2: IX comments and responses to Draft JES

    International Nuclear Information System (INIS)

    1980-01-01

    Comments received from twenty-six separate entities are included. Following each letter or set of comments are staff responses. Sections of the draft environmental statement which have been revised in response to these comments are noted

  11. IDC System Specification Document Version 1.1.

    Energy Technology Data Exchange (ETDEWEB)

    Harris, James M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lober, Randall R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-02-01

    This document contains the system specifications derived to satisfy the system requirements found in the IDC System Requirements Document for the IDC Reengineering Phase 2 project. Revisions Version Date Author/Team Revision Description Authorized by V1.0 12/2014 IDC Reengineering Project Team Initial delivery M. Harris V1.1 2/2015 IDC Reengineering Project Team Iteration I2 Review Comments M. Harris

  12. Comments on Hanford 2012 Accelerating Clean Up and Shrinking the Site

    International Nuclear Information System (INIS)

    SHERMAN, Y.T.

    2001-01-01

    In the late summer of 2000, the Department of Energy Richland Operations Office (RL) Manager, Keith Klein, announced his approach to cleanup of the Hanford Site in a document called ''Done in a Decade.'' He asked for comments and suggestions to improve the plan from employees and stakeholders. We received over 300 individual comments. Several of the comments and the Hanford Advisory Board objected to the title of the plan, leading us to change it to ''Hanford 2012 Accelerating Cleanup and Shrinking the Site.'' We addressed virtually all substantive comments, i.e. those that recommended a change in the text, better understanding of an Issue, or consideration of a new Mea, and incorporated editorial comments where appropriate. We thank all those who took time to comment. The new plan, ''Hanford 2012'', is a much better document because you did so. You will notice some things about the table: Comments are not quoted verbatim--most were paraphrased to conserve space; Comments were separated into one of four sections: general, the River, the Plateau, the Future; Commenters are not identified by name or organization; Comments are generally listed in the order in which they were received, several comments were repetitive, but differed slightly so we made an effort to respond to each one, despite apparent repetition; There are many acronyms used at the Hanford Site, most of which can be found on the Web at http:/Ewww.hanford.gov/acronyml. We have attempted to spell out each acronym the first time it's used in a comment/response with the following exceptions: DOE--Department of Energy; RL--Department of Energy, Richland Operations Office; and ORP--Department of Energy, Office of River Protection

  13. Implications of the Vienna Integrated Model of Art Perception for art-based interventions in clinical populations: Comment on "Move me, astonish me... delight my eyes and brain: The Vienna Integrated Model of top-down and bottom-up processes in Art Perception (VIMAP) and corresponding affective, evaluative, and neurophysiological correlates" by Matthew Pelowski et al.

    Science.gov (United States)

    Taruffi, Liila; Koelsch, Stefan

    2017-07-01

    Pelowski et al. present a holistic framework within which the multiple processes underlying art viewing can be systematically organized [1]. The proposed model integrates a broad range of dynamic mechanisms, which can effectively account for empirical as well as humanistic perspectives on art perception. Particularly challenging is the final section of the article, where the authors draw a correspondence between behavioral and cognitive components and brain structures (as well as networks). Here, we comment on the implications of the Vienna Integrated Model of Art Perception for art therapy in clinical populations, particularly focusing on (1) expanding Pelowski et al.'s considerations of the Default Mode Network (DMN) into discussion of its relevance to mental diseases, and (2) elaborating on empathic resonance in aesthetic contexts and the capacity of art to build up empathic skills.

  14. 78 FR 64293 - Proposed Collection; Comment Request

    Science.gov (United States)

    2013-10-28

    ... Investment Companies. OMB Number: 1545-1010. Form Number: 1120-RIC. Abstract: Internal Revenue Code sections... DEPARTMENT OF THE TREASURY Internal Revenue Service [Form 1120-RIC] Proposed Collection; Comment Request AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments. SUMMARY...

  15. 78 FR 6152 - Proposed Collection; Comment Request

    Science.gov (United States)

    2013-01-29

    ... public comment on new or revised data collections, the Railroad Retirement Board (RRB) will [email protected] . Comments regarding the information collection should be addressed to Charles Mierzwa, Railroad Retirement Board, 844 North Rush Street, Chicago, Illinois 60611-2092 or emailed to Charles...

  16. 78 FR 38412 - Proposed Collection; Comment Request

    Science.gov (United States)

    2013-06-26

    ... public comment on new or revised data collections, the Railroad Retirement Board (RRB) will [email protected] . Comments regarding the information collection should be addressed to Charles Mierzwa, Railroad Retirement Board, 844 North Rush Street, Chicago, Illinois 60611-2092 or emailed to Charles...

  17. 77 FR 18794 - Proposed Collection; Comment Request

    Science.gov (United States)

    2012-03-28

    ... to the Bureau's authorities under the Dodd-Frank Wall Street Reform and Consumer Protection Act (Dodd... BUREAU OF CONSUMER FINANCIAL PROTECTION [Docket No. CFPB-2012-0011] Proposed Collection; Comment Request AGENCY: Bureau of Consumer Financial Protection. ACTION: Notice and request for public comment...

  18. 77 FR 8841 - Proposed Collection; Comment Request

    Science.gov (United States)

    2012-02-15

    ... Force Academy announces a proposed public information collection and seeks public comment on the...://www.regulations.gov . Follow the instructions for submitting comments. Mail: Federal Docket Management... Air Force Academy. Each student's background and aptitude is reviewed to determine eligibility. If the...

  19. 78 FR 10100 - Data Specifications for Collecting Study Area Boundaries

    Science.gov (United States)

    2013-02-13

    ... comment on a process to reduce support where such an unsubsidized competitor offers voice and broadband... to determine whether unsubsidized competitors offer service within all or a portion of an incumbent's... physical surveys in order to produce the degree of accuracy required by the data specification. Incumbent...

  20. [Comments on "A practical dictionary of Chinese medicine" by Wiseman].

    Science.gov (United States)

    Lan, Feng-li

    2006-02-01

    At least 24 Chinese-English dictionaries of Chinese Medicine have been published in China during the recent 24 years (1984-2003). This thesis comments on "A Practical Dictionary of Chinese Medicine" by Wiseman, agreeing on its establishing principles, sources and formation methods of the English system of Chinese medical terminology, and pointing out the defect. The author holds that study on the origin and development of TCM terms, standardization of Chinese medical terms in different layers, i.e. Chinese medical in classic, in commonly used modern TCM terms, and integrative medical texts, are prerequisites to the standardization of English translation of Chinese medical terms.

  1. Comment on Perry and Winne's "Learning from Learning Kits: gStudy Traces of Students' Self-Regulated Engagements with Computerized Content"

    Science.gov (United States)

    Nenniger, Peter

    2006-01-01

    The comment starts with a review of the authors' four phase model of SRL as metacognitive, motivated, and strategic where it is suggested to complete the model with aspects of motivation, emotion, and attribution. Furthermore, integrating theories about "online motivation" within the model's internal regulatory part and framing it with elements of…

  2. Evolutionary considerations on complex emotions and music-induced emotions. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Gingras, Bruno; Marin, Manuela M.

    2015-06-01

    Recent efforts to uncover the neural underpinnings of emotional experiences have provided a foundation for novel neurophysiological theories of emotions, adding to the existing body of psychophysiological, motivational, and evolutionary theories. Besides explicitly modeling human-specific emotions and considering the interactions between emotions and language, Koelsch et al.'s original contribution to this challenging endeavor is to identify four brain areas as distinct "affect systems" which differ in terms of emotional qualia and evolutionary pathways [1]. Here, we comment on some features of this promising Quartet Theory of Emotions, focusing particularly on evolutionary and biological aspects related to the four affect systems and their relation to prevailing emotion theories, as well as on the role of music-induced emotions.

  3. 76 FR 76434 - Certain Integrated Circuits, Chipsets, and Products Containing Same Including Televisions...

    Science.gov (United States)

    2011-12-07

    ...Notice is hereby given that the U.S. International Trade Commission has received a complaint entitled In Re Certain Integrated Circuits, Chipsets, And Products Containing Same including Televisions, DN 2860; the Commission is soliciting comments on any public interest issues raised by the complaint.

  4. 76 FR 72010 - Proposed Collection; Comment Request

    Science.gov (United States)

    2011-11-21

    ... public comment on new or revised data collections, the Railroad Retirement Board (RRB) will publish..., and/or supporting material, contact Charles Mierzwa, the RRB Clearance Officer, at (312) 751-3363 or Charles[email protected] . Comments regarding the information collection should be addressed to Patricia...

  5. 77 FR 71176 - Proposed Collection; Comment Request

    Science.gov (United States)

    2012-11-29

    ...; Comment Request AGENCY: TRICARE Management Activity, Office of Administration, Personnel Security Division... techniques or other forms of information technology. DATES: Consideration will be given to all comments... available for public viewing on the Internet at http://www.regulations.gov as they are received without...

  6. 78 FR 29205 - Proposed Collection; Comment Request for Form 4952

    Science.gov (United States)

    2013-05-17

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Form 4952 AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments. SUMMARY... 4952, Investment Interest Expense Deduction. DATES: Written comments should be received on or before...

  7. 76 FR 51126 - Proposed Collection; Comment Request for Notice; Notice

    Science.gov (United States)

    2011-08-17

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Notice; Notice AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... in electing investment partnership (EIP). DATES: Written comments should be received on or before...

  8. 78 FR 45616 - Proposed Collection; Comment Request for Form 8960

    Science.gov (United States)

    2013-07-29

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Form 8960 AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments. SUMMARY... 8960, Net Investment Income Tax-Individuals, Estates, and Trusts. DATES: Written comments should be...

  9. 75 FR 33380 - Proposed Collection; Comment Request for Form 4952

    Science.gov (United States)

    2010-06-11

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Form 4952 AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments. SUMMARY... 4952, Investment Interest Expense Deduction. DATES: Written comments should be received on or before...

  10. 75 FR 66165 - Information Collection Activities: Proposed Collection; Comment Request

    Science.gov (United States)

    2010-10-27

    ... additional information should be collected to further the aims of government transparency. DATES: Comments... OFFICE OF MANAGEMENT AND BUDGET Information Collection Activities: Proposed Collection; Comment... are warranted. We are particularly interested in comments on whether the information collected in the...

  11. Weight Stigma Goes Viral on the Internet: Systematic Assessment of YouTube Comments Attacking Overweight Men and Women.

    Science.gov (United States)

    Jeon, Yongwoog Andrew; Hale, Brent; Knackmuhs, Eric; Mackert, Michael

    2018-03-20

    Anonymous verbal attacks against overweight individuals on social media are common and widespread. These comments often use negative, misogynist, or derogatory words, which stigmatize the targeted individuals with obesity. These verbal attacks may cause depression in overweight individuals, which could subsequently promote unhealthy eating behavior (ie, binge eating) and further weight gain. To develop an intervention policy and strategies that tackle the anonymous, Web-based verbal attacks, a thorough understanding of the comments is necessary. This study aimed to examine how anonymous users verbally attack or defend overweight individuals in terms of 3 themes: (1) topic of verbal attack (ie, what aspects of overweight individuals are verbally attacked), (2) gender of commenters and targeted overweight individuals, and (3) intensity of derogation depending on the targeted gender (ie, the number of swear words used within comments). This study analyzed the content of YouTube comments that discuss overweight individuals or groups from 2 viral videos, titled "Fat Girl Tinder Date" and "Fat Guy Tinder Date." The twin videos provide an avenue through which to analyze discussions of obesity as they organically occurred in a contemporary setting. We randomly sampled and analyzed 320 comments based on a coding instrument developed for this study. First, there were twice as many comments verbally attacking overweight individuals (n=174) than comments defending them (n=89). Second, overweight women are attacked for their capacities (eg, laziness, maturity; 14/51, 28%), whereas overweight men are attacked for their heterosocial skills (eg, rudeness, annoyance; 24/29, 83%). Third, the majority of commenters who attacked overweight women are male (42/52, 81%). Fourth, attacking comments generated toward overweight women included more swear words (mean 0.44, SD 0.77) than those targeting men (mean 0.23, SD 0.48). Our data elucidate a worrying situation of frequent disinhibited

  12. Weight Stigma Goes Viral on the Internet: Systematic Assessment of YouTube Comments Attacking Overweight Men and Women

    Science.gov (United States)

    Hale, Brent; Knackmuhs, Eric; Mackert, Michael

    2018-01-01

    Background Anonymous verbal attacks against overweight individuals on social media are common and widespread. These comments often use negative, misogynist, or derogatory words, which stigmatize the targeted individuals with obesity. These verbal attacks may cause depression in overweight individuals, which could subsequently promote unhealthy eating behavior (ie, binge eating) and further weight gain. To develop an intervention policy and strategies that tackle the anonymous, Web-based verbal attacks, a thorough understanding of the comments is necessary. Objective This study aimed to examine how anonymous users verbally attack or defend overweight individuals in terms of 3 themes: (1) topic of verbal attack (ie, what aspects of overweight individuals are verbally attacked), (2) gender of commenters and targeted overweight individuals, and (3) intensity of derogation depending on the targeted gender (ie, the number of swear words used within comments). Methods This study analyzed the content of YouTube comments that discuss overweight individuals or groups from 2 viral videos, titled “Fat Girl Tinder Date” and “Fat Guy Tinder Date.” The twin videos provide an avenue through which to analyze discussions of obesity as they organically occurred in a contemporary setting. We randomly sampled and analyzed 320 comments based on a coding instrument developed for this study. Results First, there were twice as many comments verbally attacking overweight individuals (n=174) than comments defending them (n=89). Second, overweight women are attacked for their capacities (eg, laziness, maturity; 14/51, 28%), whereas overweight men are attacked for their heterosocial skills (eg, rudeness, annoyance; 24/29, 83%). Third, the majority of commenters who attacked overweight women are male (42/52, 81%). Fourth, attacking comments generated toward overweight women included more swear words (mean 0.44, SD 0.77) than those targeting men (mean 0.23, SD 0.48). Conclusions Our data

  13. Construction of an integrated database to support genomic sequence analysis

    Energy Technology Data Exchange (ETDEWEB)

    Gilbert, W.; Overbeek, R.

    1994-11-01

    The central goal of this project is to develop an integrated database to support comparative analysis of genomes including DNA sequence data, protein sequence data, gene expression data and metabolism data. In developing the logic-based system GenoBase, a broader integration of available data was achieved due to assistance from collaborators. Current goals are to easily include new forms of data as they become available and to easily navigate through the ensemble of objects described within the database. This report comments on progress made in these areas.

  14. Medicare program; revisions to payment policies under the physician fee schedule, clinical laboratory fee schedule & other revisions to Part B for CY 2014. Final rule with comment period.

    Science.gov (United States)

    2013-12-10

    This major final rule with comment period addresses changes to the physician fee schedule, clinical laboratory fee schedule, and other Medicare Part B payment policies to ensure that our payment systems are updated to reflect changes in medical practice and the relative value of services. This final rule with comment period also includes a discussion in the Supplementary Information regarding various programs. (See the Table of Contents for a listing of the specific issues addressed in the final rule with comment period.)

  15. Harmonization of renewable electricity feed-in laws: A comment

    International Nuclear Information System (INIS)

    Soederholm, Patrik

    2008-01-01

    This comment aims at critically analyzing some of the economic efficiency issues that are raised in the paper by Munoz et al. [2007. Harmonization of renewable electricity feed-in laws in the European Union. Energy Policy 35, 3104-3114] on the harmonization of feed-in law schemes for renewable electricity in the European Union. We comment on the choice between green certificate systems and feed-in laws, but pay particular attention to the implementation and design of a harmonized feed-in law scheme. In the comment we argue first that the approach suggested by Munoz et al. tends to downplay many of the practical difficulties in assessing the real costs facing investors in renewable electricity, not the least since the presence of regulatory uncertainty about the marginal costs of renewable electricity may be essential for the choice between different support systems. Concerning the benefit side of renewable electricity promotion, the Munoz et al. (2007) paper builds on an interpretation of the EU Renewables Directive that provides plenty of room for national priorities and that therefore essentially implies that harmonized support premiums per se are of little value. We argue instead that a harmonized system should primarily address the international spillover effects from renewable electricity promotion, not the least those related to improved security of supply in Europe. There exists then a strong case for disregarding the specific national benefits of renewable electricity production in the design of harmonized support systems, and for instead considering international-perhaps at the start bilateral-policy support coordination based on entirely uniform support levels

  16. 76 FR 62098 - Proposed Collection; Comment Request

    Science.gov (United States)

    2011-10-06

    ... public comment on new or revised data collections, the Railroad Retirement Board (RRB) will publish periodic summaries of proposed data collections. Comments are invited on: (a) Whether the proposed... that the information provided is correct and the applicant's agreement to sign the form by proxy. The...

  17. 77 FR 31898 - Proposed Collection; Comment Request

    Science.gov (United States)

    2012-05-30

    ... public comment on new or revised data collections, the Railroad Retirement Board (RRB) will publish... Charles Mierzwa, Railroad Retirement Board, 844 North Rush Street, Chicago, Illinois 60611-2092 or emailed to Charles[email protected] . Written comments should be received within 60 days of this notice...

  18. 78 FR 76336 - Proposed Collection; Comment Request

    Science.gov (United States)

    2013-12-17

    ... public comment on new or revised data collections, the Railroad Retirement Board (RRB) will publish... be addressed to Charles Mierzwa, Railroad Retirement Board, 844 North Rush Street, Chicago, Illinois 60611-2092 or emailed to Charles[email protected] . Written comments should be received within 60 days of...

  19. 78 FR 13914 - Proposed Collection; Comment Request

    Science.gov (United States)

    2013-03-01

    ... public comment on new or revised data collections, the Railroad Retirement Board (RRB) will publish... collection should be addressed to Charles Mierzwa, Railroad Retirement Board, 844 North Rush Street, Chicago, Illinois 60611-2092 or emailed to Charles[email protected] . Written comments should be received within 60...

  20. 77 FR 53936 - Proposed Collection; Comment Request

    Science.gov (United States)

    2012-09-04

    ... public comment on new or revised data collections, the Railroad Retirement Board (RRB) will publish... addressed to Charles Mierzwa, Railroad Retirement Board, 844 North Rush Street, Chicago, Illinois 60611-2092 or emailed to Charles.[email protected] . Written comments should be received within 60 days of this...

  1. 78 FR 41035 - Proposed Collection; Comment Request

    Science.gov (United States)

    2013-07-09

    ...; Comment Request AGENCY: Defense Finance and Accounting Service, DoD. ACTION: Notice. SUMMARY: In compliance with Section 3506(c)(2)(A) of the Paperwork Reduction Act of 1995, the Defense Finance and Accounting Service (DFAS) announces a proposed public information collection and seeks public comment on the...

  2. 78 FR 43864 - Proposed Collection; Comment Request

    Science.gov (United States)

    2013-07-22

    ...; Comment Request AGENCY: Defense Finance and Accounting Service, DoD. ACTION: Notice. SUMMARY: In compliance with Section 3506(c)(2)(A) of the Paperwork Reduction Act of 1995, the Defense Finance and Accounting Service announces a proposed public information collection and seeks public comment on the...

  3. Response to Commentators

    Directory of Open Access Journals (Sweden)

    Tomasello Michael

    2016-03-01

    Full Text Available This paper is a reply to the comments by Henrike Moll, Glenda Satne, Ladislav Koreň and Michael Schmitz on Michael Tomasello, A Natural History of Human Thinking (Harvard University Press, 2014.

  4. Review panel comments on geomedia specific research

    International Nuclear Information System (INIS)

    Heath, C.A.

    1984-01-01

    This includes remarks made by three panel members concerning geomedia-specific repository relevant research. The scientific work in the materials area has progressed significantly. Investigators are showing a better understanding of the importance of groundwater compositions. Significant attention is being paid to the importance of colloids and complexing agents. Good planning seems to be in evidence in the Nevada program. Much cooperation and planning in the materials program is needed. Requirements concerning the performance of waste management systems were included. Other topics discussed at the symposium were interactive testing of waste forms, canister materials, and repository rock. Characterization of the chemical and physical environment in the near-field was considered by several speakers. These papers and discussions were part of the Seventh International Symposium on the Scientific Ban's for Nuclear Waste Management

  5. Comment for nuclear data from the FNS integral experiments

    International Nuclear Information System (INIS)

    Maekawa, Hiroshi

    1983-01-01

    Among the integral experiments that were carried out during last one year at FNS, the following three experimental results and their analyses are discribed. 1) Tritium production-rate distribution in a Li 2 O-C assembly, 2) Angle dependent neutron leakage spectra from Li 2 O slab assemblies, 3) Induced activity of Type 316 stainless steel. (author)

  6. 75 FR 21685 - Proposed Collection; Comment Request

    Science.gov (United States)

    2010-04-26

    ... public comment on new or revised data collections, the Railroad Retirement Board (RRB) will publish...-mail request to Charles[email protected] . Comments regarding the information collection should be... days of this notice. Charles Mierzwa, Clearance Officer. [FR Doc. 2010-9531 Filed 4-23-10; 8:45 am...

  7. 75 FR 36451 - Proposed Collection; Comment Request

    Science.gov (United States)

    2010-06-25

    ... public comment on new or revised data collections, the Railroad Retirement Board (RRB) will publish... send an e-mail request to Charles[email protected] . Comments regarding the information collection... within 60 days of this notice. Charles Mierzwa, Clearance Officer. [FR Doc. 2010-15449 Filed 6-24-10; 8...

  8. 76 FR 15351 - Proposed Collection; Comment Request

    Science.gov (United States)

    2011-03-21

    ... public comment on new or revised data collections, the Railroad Retirement Board (RRB) will publish.../Password. Completion is voluntary, however, the RRB will be unable to provide a PRC or allow a requestor to... Charles[email protected] . Comments regarding the information collection should be sent to Patricia A...

  9. 28 CFR 302.1 - Public and private sector comment procedures.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Public and private sector comment procedures. 302.1 Section 302.1 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE COMMENTS ON UNICOR BUSINESS OPERATIONS § 302.1 Public and private sector comment procedures. (a...

  10. Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway

    DEFF Research Database (Denmark)

    Lee, Jae Seong; Beuchert Kallehauge, Thomas; Pedersen, Lasse Ebdrup

    2015-01-01

    gene integration into site-specific loci in CHO cells using CRISPR/Cas9 genome editing system and compatible donor plasmid harboring a gene of interest (GOI) and short homology arms. This strategy has enabled precise insertion of a 3.7-kb gene expression cassette at defined loci in CHO cells following...

  11. Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans.

    Science.gov (United States)

    Chen, Albert Tzong-Yang; Guo, Chunfang; Itani, Omar A; Budaitis, Breane G; Williams, Travis W; Hopkins, Christopher E; McEachin, Richard C; Pande, Manjusha; Grant, Ana R; Yoshina, Sawako; Mitani, Shohei; Hu, Patrick J

    2015-10-01

    FoxO transcription factors promote longevity across taxa. How they do so is poorly understood. In the nematode Caenorhabditis elegans, the A- and F-isoforms of the FoxO transcription factor DAF-16 extend life span in the context of reduced DAF-2 insulin-like growth factor receptor (IGFR) signaling. To elucidate the mechanistic basis for DAF-16/FoxO-dependent life span extension, we performed an integrative analysis of isoform-specific daf-16/FoxO mutants. In contrast to previous studies suggesting that DAF-16F plays a more prominent role in life span control than DAF-16A, isoform-specific daf-16/FoxO mutant phenotypes and whole transcriptome profiling revealed a predominant role for DAF-16A over DAF-16F in life span control, stress resistance, and target gene regulation. Integration of these datasets enabled the prioritization of a subset of 92 DAF-16/FoxO target genes for functional interrogation. Among 29 genes tested, two DAF-16A-specific target genes significantly influenced longevity. A loss-of-function mutation in the conserved gene gst-20, which is induced by DAF-16A, reduced life span extension in the context of daf-2/IGFR RNAi without influencing longevity in animals subjected to control RNAi. Therefore, gst-20 promotes DAF-16/FoxO-dependent longevity. Conversely, a loss-of-function mutation in srr-4, a gene encoding a seven-transmembrane-domain receptor family member that is repressed by DAF-16A, extended life span in control animals, indicating that DAF-16/FoxO may extend life span at least in part by reducing srr-4 expression. Our discovery of new longevity genes underscores the efficacy of our integrative strategy while providing a general framework for identifying specific downstream gene regulatory events that contribute substantially to transcription factor functions. As FoxO transcription factors have conserved functions in promoting longevity and may be dysregulated in aging-related diseases, these findings promise to illuminate fundamental

  12. 75 FR 21370 - Proposed Collection; Comment Request

    Science.gov (United States)

    2010-04-23

    ... public comment on new or revised data collections, the Railroad Retirement Board (RRB) will publish... Charles[email protected] . Comments regarding the information collection should be addressed to Patricia A.... Charles Mierzwa, Clearance Officer. [FR Doc. 2010-9435 Filed 4-22-10; 8:45 am] BILLING CODE 7905-01-P ...

  13. 75 FR 41557 - Proposed Collection; Comment Request

    Science.gov (United States)

    2010-07-16

    ... public comment on new or revised data collections, the Railroad Retirement Board (RRB) will publish...) 751-3363 or send an e-mail request to Charles[email protected] . Comments regarding the information... received within 60 days of this notice. Charles Mierzwa, RRB Clearance Officer. [FR Doc. 2010-17368 Filed 7...

  14. 76 FR 72923 - Pool Corporation; Analysis To Aid Public Comment

    Science.gov (United States)

    2011-11-28

    ... manufacturers, warehouse them, and then resell the products to pool retail stores, pool service companies and.... ADDRESSES: Interested parties may file a comment online or on paper, by following the instructions in the... 0115'' on your comment, and file your comment online at https://ftcpublic.commentworks.com/ftc...

  15. 12 CFR 516.120 - What information should a comment include?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false What information should a comment include? 516.120 Section 516.120 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY APPLICATION PROCESSING PROCEDURES Comment Procedures § 516.120 What information should a comment include? (a...

  16. Issues of verification and validation of application-specific integrated circuits in reactor trip systems

    International Nuclear Information System (INIS)

    Battle, R.E.; Alley, G.T.

    1993-01-01

    Concepts of using application-specific integrated circuits (ASICs) in nuclear reactor safety systems are evaluated. The motivation for this evaluation stems from the difficulty of proving that software-based protection systems are adequately reliable. Important issues concerning the reliability of computers and software are identified and used to evaluate features of ASICS. These concepts indicate that ASICs have several advantages over software for simple systems. The primary advantage of ASICs over software is that verification and validation (V ampersand V) of ASICs can be done with much higher confidence than can be done with software. A method of performing this V ampersand V on ASICS is being developed at Oak Ridge National Laboratory. The purpose of the method's being developed is to help eliminate design and fabrication errors. It will not solve problems with incorrect requirements or specifications

  17. 75 FR 55736 - Mark Twain National Forest; Missouri; Integrated Non-Native Invasive Plant Project

    Science.gov (United States)

    2010-09-14

    ... DEPARTMENT OF AGRICULTURE Forest Service Mark Twain National Forest; Missouri; Integrated Non... notice of intent initiates the scoping process, which guides the development of the environmental impact... information to MTNF world wide Web site. Four comment letters were received in response to that solicitation...

  18. 75 FR 60405 - Lincoln National Forest, New Mexico, Integrated Non-Native Invasive Plant Project

    Science.gov (United States)

    2010-09-30

    ... Environmental Impact Statement. SUMMARY: The Lincoln National Forest (LNF) proposes to implement an integrated... by November 29, 2010. The draft environmental impact statement is expected January 2011 and the final environmental impact statement is expected April 2011. ADDRESSES: Send written comments to NNIP Project, Lincoln...

  19. ACHP | News | ACHP Issues Program Comment to Streamline Communication

    Science.gov (United States)

    Program Comment to Streamline Communication Facilities Construction and Modification ACHP Issues Program Comment to Streamline Communication Facilities Construction and Modification The Advisory Council on

  20. Effects of Online Comments on Smokers' Perception of Anti-Smoking Public Service Announcements.

    Science.gov (United States)

    Shi, Rui; Messaris, Paul; Cappella, Joseph N

    2014-07-01

    On YouTube anti-smoking PSAs are widely viewed and uploaded; they also receive extensive commentary by viewers. This study examined whether such evaluative comments with or without uncivil expressions influence evaluations by subsequent viewers. Results showed PSAs with positive (i.e. anti-smoking) comments were perceived by smokers as more effective than PSAs with negative (pro smoking) comments. Smokers in the no comment condition gave the highest perceived effectiveness score to PSAs. Smokers' readiness to quit smoking moderated the effect of comments on PSA evaluation. Smokers reading negative uncivil comments reported more negative attitude toward quitting and a lower level of perceived risk of smoking than those reading negative civil comments but positive civil and positive uncivil comments didn't elicit different responses.

  1. Effects of Online Comments on Smokers’ Perception of Anti-Smoking Public Service Announcements

    Science.gov (United States)

    Shi, Rui; Messaris, Paul; Cappella, Joseph N.

    2014-01-01

    On YouTube anti-smoking PSAs are widely viewed and uploaded; they also receive extensive commentary by viewers. This study examined whether such evaluative comments with or without uncivil expressions influence evaluations by subsequent viewers. Results showed PSAs with positive (i.e. anti-smoking) comments were perceived by smokers as more effective than PSAs with negative (pro smoking) comments. Smokers in the no comment condition gave the highest perceived effectiveness score to PSAs. Smokers’ readiness to quit smoking moderated the effect of comments on PSA evaluation. Smokers reading negative uncivil comments reported more negative attitude toward quitting and a lower level of perceived risk of smoking than those reading negative civil comments but positive civil and positive uncivil comments didn't elicit different responses. PMID:25561825

  2. Test and verification of a reactor protection system application-specific integrated circuit

    International Nuclear Information System (INIS)

    Battle, R.E.; Turner, G.W.; Vandermolen, R.I.; Vitalbo, C.

    1997-01-01

    Application-specific integrated circuits (ASICs) were utilized in the design of nuclear plant safety systems because they have certain advantages over software-based systems and analog-based systems. An advantage they have over software-based systems is that an ASIC design can be simple enough to not include branch statements and also can be thoroughly tested. A circuit card on which an ASIC is mounted can be configured to replace various versions of older analog equipment with fewer design types required. The approach to design and testing of ASICs for safety system applications is discussed in this paper. Included are discussions of the ASIC architecture, how it is structured to assist testing, and of the functional and enhanced circuit testing

  3. Comments on the Joint Proposed Rulemaking to Establish Light-Duty Vehicle Greenhouse Gas Emission Standards and Corporate Average Fuel Economy Standards

    Energy Technology Data Exchange (ETDEWEB)

    Wenzel, Thomas P

    2009-10-27

    I appreciate the opportunity to provide comments on the joint rulemaking to establish greenhouse gas emission and fuel economy standards for light-duty vehicles. My comments are directed at the choice of vehicle footprint as the attribute by which to vary fuel economy and greenhouse gas emission standards, in the interest of protecting vehicle occupants from death or serious injury. I have made several of these points before when commenting on previous NHTSA rulemakings regarding CAFE standards and safety. The comments today are mine alone, and do not necessarily represent the views of the US Department of Energy, Lawrence Berkeley National Laboratory, or the University of California. My comments can be summarized as follows: (1) My updated analysis of casualty risk finds that, after accounting for drivers and crash location, there is a wide range in casualty risk for vehicles with the same weight or footprint. This suggests that reducing vehicle weight or footprint will not necessarily result in increased fatalities or serious injuries. (2) Indeed, the recent safety record of crossover SUVs indicates that weight reduction in this class of vehicles resulted in a reduction in fatality risks. (3) Computer crash simulations can pinpoint the effect of specific design changes on vehicle safety; these analyses are preferable to regression analyses, which rely on historical vehicle designs, and cannot fully isolate the effect of specific design changes, such as weight reduction, on crash outcomes. (4) There is evidence that automakers planned to build more large light trucks in response to the footprint-based light truck CAFE standards. Such an increase in the number of large light trucks on the road may decrease, rather than increase, overall safety.

  4. Immigrants in Slovenia: Integration Aspects

    Directory of Open Access Journals (Sweden)

    Janja Žitnik

    2004-09-01

    Full Text Available On the basis of the latest statistics, the author estimates the present share of first- and second-generation immigrants in Slovenia’s population. After examining the quantity and intensity of those public efforts in Slovenia that have been focused on unresolved problems of the immigrants’ social and cultural integration, she continues to question the equality of immigrant minorities in Slovenia, and the sufficiency of the existing programs aimed at facilitating their integration with Slovenian society at large. She explains her doubts about the general assumption that a very clear distinction should be made between the rights of the autochthonous minorities and those of the immigrant ones as far as their special protection is concerned. In the third section of this article, the author discusses the social-ethnic stratification of Slovenian society and tries to look into the psychological background of the nationality/ethnicity statistics. She presents some aspects of the immigrants’ daily experience in Slovenian social, cultural, educational and working milieu, and points to the authorities’ attitude toward them. She comments on the burning issue of the “deleted residents”, and illustrates it with the experience of one of the persons involved. The fourth section, in which the most regular symptoms of Slovenian xenophobia are presented, consists of first-hand observations and focuses on the daily human attitude of the national majority towards the immigrant minorities. Finally the author compares the nature of the specific needs of Slovenians as a “European national minority” with the needs of the immigrant minorities in Slovenia.

  5. The Impact of Teachers' Commenting Strategies on Children's Vocabulary Growth

    Science.gov (United States)

    Barnes, Erica M.; Dickinson, David K.

    2017-01-01

    We examined the relations between teachers' use of comments during book reading sessions in preschool classrooms and the vocabulary growth of children with low and moderately low language ability. Using data from a larger randomized controlled trial, we analyzed comments defined as utterances that give, explain, expand, or define. Comments were…

  6. Design and Verification of Application Specific Integrated Circuits in a Network of Online Labs

    Directory of Open Access Journals (Sweden)

    A.Y. Al-Zoubi

    2009-08-01

    Full Text Available A solution to implement a remote laboratory for testing and designing analog Application-Specific Integrated Circuits of the type (ispPAC10 is presented. The application allows electrical engineering students to access and perform measurements and conduct analog electronics experiments over the internet. PAC-Designer software, running on a Citrix server, is used in the circuit design in which the signals are generated and the responses are acquired by a data acquisition board controlled by LabVIEW. Three interconnected remote labs located in three different continents will be implementing the proposed system.

  7. Safety technology comments on Cattenom nuclear power station

    International Nuclear Information System (INIS)

    1986-01-01

    The comments are based on the safety report for the identical Flamanville plant, on the contract documents for the DUP and on results of consultancy by the DFK Working Party and on replies from the French side in the context of a German list of questions. The comments refer to the state in spring 1982. According to the agreement made for the catalogue of questions Cattenom/KKP 2, the 1300 MW Philippsburg II nuclear power station is used as a German comparable plant in these comments. Reference is made to the German comparable plant in the description and assessment of important parts of the plant. The main points of the safety technology comments are in the assessment of site characteristics; the safety technology concept; the derivation of radio-active materials and the radiation exposure in the adjacent German area. (orig./HP) [de

  8. 14 CFR 11.45 - Where and when do I file my comments?

    Science.gov (United States)

    2010-01-01

    ... you do not follow the electronic filing instructions at the Federal Docket Management System Web site... do I file my comments? (a) Send your comments to the location specified in the rulemaking document on which you are commenting. If you are asked to send your comments to the Federal Document Management...

  9. A comment on the viability of the allowance for corporate equity

    OpenAIRE

    John Isaac

    1997-01-01

    This article, acknowledging the potentially important general attractions of the allowance for corporate equity (ACE), looks at some of its more specific implications. On corporate taxes, the article looks at questions about the implied revenue-neutral rate of corporation tax (and redistribution of the tax burden); the effects on cash flow of both government and companies; and what would become a crucially important charge on capital gains. On income tax, the article comments on the implicati...

  10. 12 CFR 516.140 - How long is the comment period?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false How long is the comment period? 516.140 Section 516.140 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY APPLICATION PROCESSING PROCEDURES Comment Procedures § 516.140 How long is the comment period? (a) General. Except as...

  11. 12 CFR 516.110 - Who may submit a written comment?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Who may submit a written comment? 516.110 Section 516.110 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY APPLICATION PROCESSING PROCEDURES Comment Procedures § 516.110 Who may submit a written comment? Any person may submit a...

  12. 10 CFR 1045.22 - No comment policy.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false No comment policy. 1045.22 Section 1045.22 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Identification of Restricted Data and Formerly Restricted Data Information § 1045.22 No comment policy. (a) Authorized holders of RD and FRD shall not confirm or expand...

  13. Emotions and feelings as the body's comment to personal relationships:

    DEFF Research Database (Denmark)

    Willert, Søren

    as eflections of phylogenetically evolved, evaluative and apperceptively based action systems helping organisms to structure and relate in adaptive fashion to their species-specific Umwelt. One special feature of humans' emotional life, setting our species apart from all other, is that emotions not only guide...... describing - as the title does - emotions and feelings as the body's (subjectively experienced) comments to personal relationships. A model of human self- or second order consciousness, consistent with the described theoretical framework, will be presented. Implications of the model for the understanding...

  14. 77 FR 13175 - Proposed Collection: Comment Request

    Science.gov (United States)

    2012-03-05

    ... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the... written comments to Bureau of the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity to make comments online is also available at...

  15. 77 FR 65248 - Proposed Collection: Comment Request

    Science.gov (United States)

    2012-10-25

    ... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the... consideration. ADDRESSES: Direct all written comments to Bureau of the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity to make comments...

  16. 77 FR 43430 - Proposed Collection: Comment Request

    Science.gov (United States)

    2012-07-24

    ... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the... consideration. ADDRESSES: Direct all written comments to Bureau of the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity to make comments...

  17. 77 FR 19057 - Proposed Collection: Comment Request

    Science.gov (United States)

    2012-03-29

    ... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the... comments to Bureau of the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity to make comments online is also available at www...

  18. 78 FR 34161 - Proposed Collection: Comment Request

    Science.gov (United States)

    2013-06-06

    ... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the...: Direct all written comments to Bureau of the Fiscal Service, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity to make comments online is also...

  19. 77 FR 19058 - Proposed Collection: Comment Request

    Science.gov (United States)

    2012-03-29

    ... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the...: Direct all written comments to Bureau of the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity to make comments online is also...

  20. 77 FR 32178 - Proposed Collection: Comment Request

    Science.gov (United States)

    2012-05-31

    ... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the... comments to Bureau of the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity to make comments online is also available at www...

  1. 76 FR 61479 - Proposed Collection: Comment Request

    Science.gov (United States)

    2011-10-04

    ... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the... written comments to Bureau of the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity to make comments online is also available at...

  2. 77 FR 74053 - Proposed Collection: Comment Request

    Science.gov (United States)

    2012-12-12

    ... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the... consideration. ADDRESSES: Direct all written comments to Bureau of the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity to make comments...

  3. 77 FR 19754 - Proposed Collection: Comment Request

    Science.gov (United States)

    2012-04-02

    ... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the... all written comments to Bureau of the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity to make comments online is also...

  4. 78 FR 25535 - Proposed Collection; Comment Request

    Science.gov (United States)

    2013-05-01

    ... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the... written comments to Bureau of the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity to make comments online is also available at...

  5. 77 FR 5090 - Proposed Collection: Comment Request

    Science.gov (United States)

    2012-02-01

    ... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently the... all written comments to Bureau of the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity to make comments online is also...

  6. 78 FR 149 - Proposed Collection: Comment Request

    Science.gov (United States)

    2013-01-02

    ... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the... consideration. ADDRESSES: Direct all written comments to Bureau of the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity to make comments...

  7. Integrity evaluation of power plant components by fracture mechanics and related techniques

    International Nuclear Information System (INIS)

    Mukherjee, B.; Vanderglas, M.L.; Davies, P.H.

    1982-01-01

    Power plant components can be subject to unexpected failures with serious consequences, unless careful attention is paid to minute crack defects and their possible growth. The Linear Elastic Fracture Mechanics approach to structural integrity evaluation, as it appears in the ASME Code, is discussed. Projects related to material data generation and the development of structural analysis methods to make the above method usable are described. Several integrity-related questions outside the scope of the Code guidelines are documented, concluding with comments on possible future developments

  8. 78 FR 53195 - Proposed Information Collection (Dental Patient Satisfaction Survey) Activity: Comment Request

    Science.gov (United States)

    2013-08-28

    ... Patient Satisfaction Survey) Activity: Comment Request AGENCY: Veterans Health Administration, Department... notice solicits comments for information needed to measure patient satisfaction with VA's dental services... Patient Satisfaction Survey)'' in any correspondence. During the comment period, comments may be viewed...

  9. Final environmental impact statement for the Nevada test site and off-site locations in the State of Nevada. Public comment and response document, Volume 3, Part A comments

    International Nuclear Information System (INIS)

    1996-08-01

    On February 2, 1996, the U.S. Department of Energy (DOE) issued the Draft Environmental Impact Statement for the Nevada Test Site and Off-Site Locations in the State of Nevada (NTS EIS) for review by the state of Nevada, Indian tribes, local governments, other federal agencies, groups and organizations, and the general public. The formal comment period lasted 90 days, ending May 3, 1996. As part of the comment process, the DOE held public hearings in St. George, Utah, and in Pahrump, Reno, and Las Vegas, Nevada. Community Workshops were held in Caliente, Tonopah, Boulder City, and North Las Vegas, Nevada, in conjunction with the University of Nevada Las Vegas to discuss the Draft NTS EIS. Volume 3 of the Final NTS EIS contains 3 chapters. Chapter 1 summarizes the major issues raised by the public. Chapter 2 contains the full text of the public comments on the Draft NTS EIS received by the DOE; it includes public hearing transcripts, written comments, and comments received via a toll-free comment open-quotes hot line.close quotes Chapter 3 contains the DOE's responses to the public comments and describes how the comments were considered in the Final NTS EIS

  10. Online reputation systems: The effects of feedback comments and reactions on building and rebuilding trust in online auctions

    NARCIS (Netherlands)

    Utz, S.; Matzat, U.; Snijders, C.

    2009-01-01

    Previous research on reputation systems primarily focused on their trust-building function. The present research addresses their trust-rebuilding function-specifically, the role of the short text comments given in reaction to negative feedback. Rebuilding trust is often necessary because on-line

  11. TripAdvisor Comments: What are they talking about?

    Directory of Open Access Journals (Sweden)

    F. Amaral

    2015-12-01

    Full Text Available Social networks’ popularity has enabled new approaches in customer-business relationships, particularly in regard to tourism. Much of this is due to the global character of social networks, and the fact that tourists can freely discuss their experiences, making these comments available to others instantly. References found in literature considered the determinants, motivations and adoption of other tourists’ evaluations, and how they can be helpful to peers. These studies have been compiled based on quantitative information, particularly regarding rankings based on the number of comments and reviewers that companies have on content management sites. However, tourist evaluations go beyond just assigning a rating—there are also unstructured comments, and these have not been the object of much analysis. Thus, this work’s focus is on the analysis of the content of comments using the institutional Dineserv model, applied to restaurants and adapting it to social media.

  12. Grid connected integrated community energy system. Phase II: final stage 2 report. Outline specifications of cogeneration plant; continued

    Energy Technology Data Exchange (ETDEWEB)

    1978-03-22

    Specifications are presented for the electrical equipment, site preparation, building construction and mechanical systems for a dual-purpose power plant to be located on the University of Minnesota campus. This power plant will supply steam and electrical power to a grid-connected Integrated Community Energy System. (LCL)

  13. Integrated Mission Precision Attack Cockpit Technology (IMPACT). Phase 1: Identifying Technologies for Air-to-Ground Fighter Integration.

    Science.gov (United States)

    1994-10-31

    No comment S4: No comment 63 3. The HMD would my...released (i.e., not hung) without looking down on the PACS page is very good." S4: No comment 6. The HMD would my SITUATIONAL AWARENESS during the INGRESS...Substantially Degrade 0 (Subject 1: NO RATING) HOW? S 1: No comment S2: "Previous reasons, visibility REF # 2, 4" S3: No comment S4: No comment 65 7. The

  14. 78 FR 57639 - Request for Comments on Pediatric Planned Procedure Algorithm

    Science.gov (United States)

    2013-09-19

    ... Comments on Pediatric Planned Procedure Algorithm AGENCY: Agency for Healthcare Research and Quality (AHRQ), HHS. ACTION: Notice of request for comments on pediatric planned procedure algorithm from the members... Quality (AHRQ) is requesting comments from the public on an algorithm for identifying pediatric planned...

  15. 77 FR 69547 - Proposed Collection: Comment Request

    Science.gov (United States)

    2012-11-19

    ... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the.... ADDRESSES: Direct all written comments to Bureau of the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity to make comments online is also...

  16. 78 FR 25533 - Proposed Collection; Comment Request

    Science.gov (United States)

    2013-05-01

    ... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the.... ADDRESSES: Direct all written comments to Bureau of the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity to make comments online is also...

  17. 1647 comments.pmd

    African Journals Online (AJOL)

    driniev

    ask for fax line). Cell: +2772 40 59 561. E-mail: frank.winde@gmx.de. Comments on: “Gold tailings as a source of waterborne uranium contamination of streams – The Koekemoerspruit as a case study” published in Water SA 30 (2) 219-240.

  18. In science "there is no bad publicity": papers criticized in comments have high scientific impact.

    Science.gov (United States)

    Radicchi, Filippo

    2012-01-01

    Comments are special types of publications whose aim is to correct or criticize previously published papers. For this reason, comments are believed to make commented papers less worthy or trusty to the eyes of the scientific community, and thus predestined to have low scientific impact. Here, we show that such belief is not supported by empirical evidence. We consider thirteen major publication outlets in science, and perform systematic comparisons between the citations accumulated by commented and non commented articles. We find that (i) commented papers are, on average, much more cited than non commented papers, and (ii) commented papers are more likely to be among the most cited papers of a journal. Since comments are published soon after criticized papers, comments should be viewed as early indicators of the future impact of criticized papers.

  19. 75 FR 5855 - Proposed Collection; Comment Request for Form 8038-TC

    Science.gov (United States)

    2010-02-04

    ... 8038-TC AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... comments concerning Form 8038-TC, Information Return for Tax Credit Bonds. DATES: Written comments should...: Form 8038-TC. Abstract: Form 8038-TC will be used by issuers of qualified tax- exempt credit bonds...

  20. Cross-Cultural Career Psychology: Comment on Fouad, Harmon, and Borgen (1997) and Tracey, Watanabe, and Schneider (1997).

    Science.gov (United States)

    Leong, Frederick T. L.

    1997-01-01

    Uses the theoretical framework of cultural validity and cultural specificity in career psychology to comment on theoretical and methodological issues raised by two articles on cross-cultural career psychology. Discusses the distinction between etic and emic approaches to cross-cultural research and the role of cultural context in understanding…

  1. 78 FR 38041 - Agency Information Collection Activities; Submission for OMB review; Comment Request

    Science.gov (United States)

    2013-06-25

    ... parties may file a comment online or on paper, by following the instructions in the Request for Comment... your comment and file your comment online at https://ftcpublic.commentworks.com/ftc/tsrrulepra2 by...: Craig Tregillus, Attorney, Division of Marketing Practices, Bureau of Consumer Protection, Federal Trade...

  2. Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs.

    Directory of Open Access Journals (Sweden)

    Christopher D Brown

    Full Text Available Genetic variants in cis-regulatory elements or trans-acting regulators frequently influence the quantity and spatiotemporal distribution of gene transcription. Recent interest in expression quantitative trait locus (eQTL mapping has paralleled the adoption of genome-wide association studies (GWAS for the analysis of complex traits and disease in humans. Under the hypothesis that many GWAS associations tag non-coding SNPs with small effects, and that these SNPs exert phenotypic control by modifying gene expression, it has become common to interpret GWAS associations using eQTL data. To fully exploit the mechanistic interpretability of eQTL-GWAS comparisons, an improved understanding of the genetic architecture and causal mechanisms of cell type specificity of eQTLs is required. We address this need by performing an eQTL analysis in three parts: first we identified eQTLs from eleven studies on seven cell types; then we integrated eQTL data with cis-regulatory element (CRE data from the ENCODE project; finally we built a set of classifiers to predict the cell type specificity of eQTLs. The cell type specificity of eQTLs is associated with eQTL SNP overlap with hundreds of cell type specific CRE classes, including enhancer, promoter, and repressive chromatin marks, regions of open chromatin, and many classes of DNA binding proteins. These associations provide insight into the molecular mechanisms generating the cell type specificity of eQTLs and the mode of regulation of corresponding eQTLs. Using a random forest classifier with cell specific CRE-SNP overlap as features, we demonstrate the feasibility of predicting the cell type specificity of eQTLs. We then demonstrate that CREs from a trait-associated cell type can be used to annotate GWAS associations in the absence of eQTL data for that cell type. We anticipate that such integrative, predictive modeling of cell specificity will improve our ability to understand the mechanistic basis of human

  3. 78 FR 70046 - Agency Information Collection Activities; Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-11-22

    ... parties may file a comment online or on paper, by following the instructions in the Request for Comment... Gans, Attorney, Division of Marketing Practices, Bureau of Consumer Protection, Federal Trade...) = $480,189 Request for Comment You can file a comment online or on paper. For the Commission to consider...

  4. 2003 Employee Attitude Survey: Analysis of Employee Comments

    Science.gov (United States)

    2005-06-01

    171 --- Reporting Allegations Abuse of MWE Complaint Process (Excessive Complaints) 191 --- Satisfaction with Employee Assistance Program ( EAP ) 251...Satisfaction with Employee Assistance Program ( EAP ) --------------------------------------- General Comments about FAA Policies, Practices, and...contracting; understaffing; FAA policies, practices, and programs ; encouraging hard work; management concern for employees ; promotion equity; comments

  5. Rapid development of stable transgene CHO cell lines by CRISPR/Cas9-mediated site-specific integration into C12orf35.

    Science.gov (United States)

    Zhao, Menglin; Wang, Jiaxian; Luo, Manyu; Luo, Han; Zhao, Meiqi; Han, Lei; Zhang, Mengxiao; Yang, Hui; Xie, Yueqing; Jiang, Hua; Feng, Lei; Lu, Huili; Zhu, Jianwei

    2018-07-01

    Chinese hamster ovary (CHO) cells are the most widely used mammalian hosts for recombinant protein production. However, by conventional random integration strategy, development of a high-expressing and stable recombinant CHO cell line has always been a difficult task due to the heterogenic insertion and its caused requirement of multiple rounds of selection. Site-specific integration of transgenes into CHO hot spots is an ideal strategy to overcome these challenges since it can generate isogenic cell lines with consistent productivity and stability. In this study, we investigated three sites with potential high transcriptional activities: C12orf35, HPRT, and GRIK1, to determine the possible transcriptional hot spots in CHO cells, and further construct a reliable site-specific integration strategy to develop recombinant cell lines efficiently. Genes encoding representative proteins mCherry and anti-PD1 monoclonal antibody were targeted into these three loci respectively through CRISPR/Cas9 technology. Stable cell lines were generated successfully after a single round of selection. In comparison with a random integration control, all the targeted integration cell lines showed higher productivity, among which C12orf35 locus was the most advantageous in both productivity and cell line stability. Binding affinity and N-glycan analysis of the antibody revealed that all batches of product were of similar quality independent on integrated sites. Deep sequencing demonstrated that there was low level of off-target mutations caused by CRISPR/Cas9, but none of them contributed to the development process of transgene cell lines. Our results demonstrated the feasibility of C12orf35 as the target site for exogenous gene integration, and strongly suggested that C12orf35 targeted integration mediated by CRISPR/Cas9 is a reliable strategy for the rapid development of recombinant CHO cell lines.

  6. Comments on the Joint Proposed Rulemaking to Establish Light-Duty Vehicle Greenhouse Gas Emission Standards and Corporate Average Fuel Economy Standards

    Energy Technology Data Exchange (ETDEWEB)

    Wenzel, Tom [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2009-10-27

    Tom Wenzel of Lawrence Berkeley National Laboratory comments on the joint rulemaking to establish greenhouse gas emission and fuel economy standards for light-duty vehicle, specifically on the relationship between vehicle weight and vehicle safety.

  7. 77 FR 26020 - Ryan White HIV/AIDS Program Solicitation of Comments

    Science.gov (United States)

    2012-05-02

    ... HIV/AIDS Program Solicitation of Comments AGENCY: Health Resources and Services Administration (HRSA... solicits comments on Parts A through F of the Ryan White HIV/AIDS Program. Comments are solicited to inform... Public Health Service Act (PHS), as amended by the Ryan White HIV/AIDS Treatment Extension Act of 2009...

  8. The Social Dimension of Computer-Integrated Manufacturing: An Extended Comment.

    Science.gov (United States)

    Badham, Richard J.

    1991-01-01

    The effect of computer-integrated manufacturing (CIM) on working conditions depends on the way in which the technologies are designed to fit operator requirements, work organization, and organizational objectives. Recent attempts to promote skill-based human-centered approaches to CIM design are aimed at introducing humane working conditions…

  9. How to Make Friends and Influence People on the Internet: A Dissertation on Popular Comments on Blogs

    Science.gov (United States)

    Yucel, Ibrahim

    2011-01-01

    Blogs, specifically special-interest blogs, generate in-depth discussions. These discussions offer a new window for researching emerging trends in both consumer behavior and social-political attitudes. Many people try to influence these discussions and trends via participation, but making an impact is not guaranteed. Not all comments have the same…

  10. Response to a comment on Cullen K "From Squires Quest! II: A serious video game intervention": Methodological issues

    Science.gov (United States)

    In response to comments about our article, "Meal-specific dietary changes from Squires Quest! II: a serious video game intervention," we concur that studies on video game interventions are important. A future study with a control group receiving no video game intervention and the collection of poten...

  11. Weight comments by family and significant others in young adulthood.

    Science.gov (United States)

    Eisenberg, Marla E; Berge, Jerica M; Fulkerson, Jayne A; Neumark-Sztainer, Dianne

    2011-01-01

    Weight teasing is common among adolescents, but less is known about the continuation of this experience during young adulthood. The present study uses survey data from a diverse sample of 2287 young adults, who participated in a 10-year longitudinal study of weight-related issues to examine hurtful weight comments by family members or a significant other. Among young adults, 35.9% of females and 22.8% of males reported receiving hurtful weight-related comments by family members, and 21.2% of females and 23.8% of males with a significant other had received hurtful weight-related comments from this source. Hispanic and Asian young adults and overweight/obese young adults were more likely to report receiving comments than those in other groups. Weight teasing during adolescence predicted hurtful weight-related comments in young adulthood, with some differences by gender. Findings suggest that hurtful weight talk continues into young adulthood and is predicted by earlier weight teasing experiences. Copyright © 2010 Elsevier Ltd. All rights reserved.

  12. Summary of comments received from workshops on radiological criteria for decommissioning

    International Nuclear Information System (INIS)

    Caplin, J.; Page, G.; Smith, D.; Wiblin, C.

    1994-01-01

    The Nuclear Regulatory Commission (NRC) is conducting an enhanced participatory rulemaking to establish radiological criteria for site cleanup and decommissioning of NRC-licensed facilities. Open public meetings were held during 1993 in Chicago, IL, San Francisco, CA, Boston, MA, Dallas, TX, Philadelphia, PA, Atlanta, GA, and Washington, DC. Interested parties were invited to provide input on the rulemaking issues before the NRC staff develops a draft proposed rule. This report summarizes 3,635 comments categorized from transcripts of the seven workshops and 1,677 comments from 100 NRC docketed letters from individuals and organizations. No analysis or response to the comments is included. The comments reflect a broad spectrum of viewpoints on the issues related to radiological criteria for site cleanup and decommissioning. The NRC also held public meetings on the scope of the Generic Environmental Impact Statement (GEIS) during July 1993. The GEIS meetings were held in Washington, DC., San Francisco, CA, Oklahoma City, OK, and Cleveland, OH. Related comments from these meetings were reviewed and comments which differed substantially from those from the workshops are also summarized in the body of the report. A summary of the comments from the GEIS scoping meetings is included as an Appendix

  13. Summary of comments received from workshops on radiological criteria for decommissioning

    Energy Technology Data Exchange (ETDEWEB)

    Caplin, J.; Page, G.; Smith, D.; Wiblin, C. [Advanced Systems Technology, Inc., Atlanta, GA (United States)

    1994-01-01

    The Nuclear Regulatory Commission (NRC) is conducting an enhanced participatory rulemaking to establish radiological criteria for site cleanup and decommissioning of NRC-licensed facilities. Open public meetings were held during 1993 in Chicago, IL, San Francisco, CA, Boston, MA, Dallas, TX, Philadelphia, PA, Atlanta, GA, and Washington, DC. Interested parties were invited to provide input on the rulemaking issues before the NRC staff develops a draft proposed rule. This report summarizes 3,635 comments categorized from transcripts of the seven workshops and 1,677 comments from 100 NRC docketed letters from individuals and organizations. No analysis or response to the comments is included. The comments reflect a broad spectrum of viewpoints on the issues related to radiological criteria for site cleanup and decommissioning. The NRC also held public meetings on the scope of the Generic Environmental Impact Statement (GEIS) during July 1993. The GEIS meetings were held in Washington, DC., San Francisco, CA, Oklahoma City, OK, and Cleveland, OH. Related comments from these meetings were reviewed and comments which differed substantially from those from the workshops are also summarized in the body of the report. A summary of the comments from the GEIS scoping meetings is included as an Appendix.

  14. Experiences from the formal specification of the integration platform and the synthesis of SDT with the software bus

    International Nuclear Information System (INIS)

    Thunem, Harald; Mohn, Peter; Sandmark, Haakon; Stoelen, Ketil

    1999-04-01

    The three year programme 1997-1999 for the OECD Halden Reactor Project (HRP) identifies the need to gain experience from applying formal techniques in real-life system developments. This motivated the initiation of the HRP research activity Integration of Formal Specification in the Development of HAMMLAB 2000 (INT-FS). The principal objective was to experiment with formal techniques in system developments at the HRP; in particular, system developments connected to HAMMLAB 2000 - the computerised laboratory for man-machine-interaction experiments currently under construction. It was hoped that this experimentation with formal techniques should result in a better understanding of how such techniques should be utilised in a more industrial setting. To obtain more knowledge with respect to the practical effects and consequences of an increased level of formalization was another objective. This report summarises experiences, results and conclusions from a pre-study addressing INT-FS related issues connected to the development of the HAMMLAB 2000 Integration Platform (IP). The report starts by giving a brief overview of the IP. Then it describes and summarises experiences from the formalization of a top-level requirements specification for the IP. Finally, it discusses various approaches for the integration of applications generated automatically through the CASE-tool SDT and the Software Bus on which the communication within HAMMLAB 2000 will be based. The report concludes that the selected formalisms and tools are well-suited to describe IP-like systems. The report also concludes that the integration of SDT applications with the Software Bus will not be a major obstacle, and finally that a monitoring component for the IP is well-suited for development within INT-FS (author) (ml)

  15. Event-specific qualitative and quantitative PCR detection of the GMO carnation (Dianthus caryophyllus) variety Moonlite based upon the 5'-transgene integration sequence.

    Science.gov (United States)

    Li, P; Jia, J W; Jiang, L X; Zhu, H; Bai, L; Wang, J B; Tang, X M; Pan, A H

    2012-04-27

    To ensure the implementation of genetically modified organism (GMO)-labeling regulations, an event-specific detection method was developed based on the junction sequence of an exogenous integrant in the transgenic carnation variety Moonlite. The 5'-transgene integration sequence was isolated by thermal asymmetric interlaced PCR. Based upon the 5'-transgene integration sequence, the event-specific primers and TaqMan probe were designed to amplify the fragments, which spanned the exogenous DNA and carnation genomic DNA. Qualitative and quantitative PCR assays were developed employing the designed primers and probe. The detection limit of the qualitative PCR assay was 0.05% for Moonlite in 100 ng total carnation genomic DNA, corresponding to about 79 copies of the carnation haploid genome; the limit of detection and quantification of the quantitative PCR assay were estimated to be 38 and 190 copies of haploid carnation genomic DNA, respectively. Carnation samples with different contents of genetically modified components were quantified and the bias between the observed and true values of three samples were lower than the acceptance criterion (GMO detection method. These results indicated that these event-specific methods would be useful for the identification and quantification of the GMO carnation Moonlite.

  16. Testing Requirements to Manage Data Exchange Specifications in Enterprise Integration - A Schema Design Quality Focus.

    Energy Technology Data Exchange (ETDEWEB)

    Kulvatunyou, Boonserm [ORNL; Ivezic, Nenad [ORNL; Buhwan, Jeong [POSTECH University, South Korea

    2004-07-01

    In this paper, we describe the requirements to test W3C XML Schema usage when defining message schemas for data exchange in any large and evolving enterprise integration project. We then decompose the XML Schema testing into four (4) aspects including the message schema conformance to the XML Schema specification grammar, the message schema conformance to the XML Schema specification semantics, the message schema conformance to design quality testing, and canonical semantics testing of the message schema. We describe these four testing aspects in some detail and point to other related efforts. We further focus to provide some technical details for the message schema design quality testing. As a future work, we describe the requirements for canonical semantics testing and potential solution approaches. Finally, we describe an implementation architecture for the message schema design quality testing.

  17. 78 FR 60020 - Proposed Collection: Comment Request for Voluntary Customer Satisfaction Surveys

    Science.gov (United States)

    2013-09-30

    ... Voluntary Customer Satisfaction Surveys ACTION: Notice and request for comments. SUMMARY: The Department of... Treasury is soliciting comments concerning the Customer Satisfaction Survey. DATES: Written comments should..., WV 26106-1328, (304) 480- 8150. SUPPLEMENTARY INFORMATION: Title: Voluntary Customer Satisfaction...

  18. Hanford Integrated Planning Process: 1993 Hanford Site-specific science and technology plan

    International Nuclear Information System (INIS)

    1993-12-01

    This document is the FY 1993 report on Hanford Site-specific science and technology (S ampersand T) needs for cleanup of the Site as developed via the Hanford Integrated Planning Process (HIPP). It identifies cleanup problems that lack demonstrated technology solutions and technologies that require additional development. Recommendations are provided regarding allocation of funding to address Hanford's highest-priority technology improvement needs, technology development needs, and scientific research needs, all compiled from a Sitewide perspective. In the past, the S ampersand T agenda for Hanford Site cleanup was sometimes driven by scientists and technologists, with minimal input from the ''problem owners'' (i.e., Westinghouse Hanford Company [WHC] staff who are responsible for cleanup activities). At other times, the problem-owners made decisions to proceed with cleanup without adequate scientific and technological inputs. Under both of these scenarios, there was no significant stakeholder involvement in the decision-making process. One of the key objectives of HIPP is to develop an understanding of the integrated S ampersand T requirements to support the cleanup mission, (a) as defined by the needs of the problem owners, the values of the stakeholders, and the technology development expertise that exists at Hanford and elsewhere. This requires a periodic, systematic assessment of these needs and values to appropriately define a comprehensive technology development program and a complementary scientific research program. Basic to our success is a methodology that is defensible from a technical perspective and acceptable to the stakeholders

  19. 76 FR 49479 - Franchise Rule Information Collection Activities; Proposed Collection; Comment Request

    Science.gov (United States)

    2011-08-10

    ... FEDERAL TRADE COMMISSION Franchise Rule Information Collection Activities; Proposed Collection... Concerning Franchising (``Franchise Rule''). That clearance expires on December 31, 2011. DATES: Comments... INFORMATION section below. Write ``Franchise Rule, PRA Comment, FTC File No. P094400'' on your comment, and...

  20. A Domain Specific Embedded Language in C++ for Automatic Differentiation, Projection, Integration and Variational Formulations

    Directory of Open Access Journals (Sweden)

    Christophe Prud'homme

    2006-01-01

    Full Text Available In this article, we present a domain specific embedded language in C++ that can be used in various contexts such as numerical projection onto a functional space, numerical integration, variational formulations and automatic differentiation. Albeit these tools operate in different ways, the language overcomes this difficulty by decoupling expression constructions from evaluation. The language is implemented using expression templates and meta-programming techniques and uses various Boost libraries. The language is exercised on a number of non-trivial examples and a benchmark presents the performance behavior on a few test problems.

  1. CEO Appointments and the Loss of Firm-specific Knowledge - Putting Integrity Back into Hiring Decisions

    DEFF Research Database (Denmark)

    Rost, Katja; Salomo, Søren

    2008-01-01

    the last thirty years. Assuming that general managerial skills are becoming more important relative to firm-specific skills, the authors conclude that competition in the managerial labor market establishes optimal contracts. In our model and our empirical analysis we question this explanation by assuming...... that over the past decades the dishonesty of the predecessor has become relatively more important for the appointment decisions of firms. We conclude that outside hires are a suboptimal trend because external candidates even step up the regression of integrity in firms: As nobody has an incentive to invest...

  2. CEO Appointments and the Loss of Firm-Specific Knowledge - Putting Integrity Back into Hiring Decisions

    DEFF Research Database (Denmark)

    Rost, Katja; Salomo, Søren; Osterloh, Margit

    2008-01-01

    the last thirty years. Assuming that general managerial skills are becoming more important relative to firm-specific skills, the authors conclude that competition in the managerial labor market establishes optimal contracts. In our model and our empirical analysis we question this explanation by assuming...... that over the past decades the dishonesty of the predecessor has become relatively more important for the appointment decisions of firms. We conclude that outside hires are a suboptimal trend because external candidates even step up the regression of integrity in firms: As nobody has an incentive to invest...

  3. 75 FR 39583 - Agency Information Collection Activities: Comment Request

    Science.gov (United States)

    2010-07-09

    ... the World Wide Web. The survey is a fully automated web data collection effort and is handled... NATIONAL SCIENCE FOUNDATION Agency Information Collection Activities: Comment Request AGENCY: National Science Foundation. ACTION: Notice; Submission for OMB Review; Comment Request. SUMMARY: The...

  4. 75 FR 29368 - Agency Information Collection Activities: Comment Request

    Science.gov (United States)

    2010-05-25

    ... made available to researchers on CD-ROM and on the World Wide Web. Mathematica Policy Research will... NATIONAL SCIENCE FOUNDATION Agency Information Collection Activities: Comment Request AGENCY: National Science Foundation. ACTION: Submission for OMB review; comment request. SUMMARY: The National...

  5. 77 FR 33227 - Assessment Questionnaire-IP Sector Specific Agency Risk Self Assessment Tool (IP-SSARSAT)

    Science.gov (United States)

    2012-06-05

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0069] Assessment Questionnaire--IP Sector... comments concerning new Information Collection Request--Assessment Questionnaire--IP Sector Specific Agency... http://www.regulations.gov , including any personal information provided. OMB is particularly...

  6. 77 FR 33218 - Graco, Inc.; Analysis of Proposed Agreement Containing Consent Orders To Aid Public Comment

    Science.gov (United States)

    2012-06-05

    ... ``Graco, Dkt. No. 9350'' on your comment, and file your comment online at https://ftcpublic.commentworks... ``Graco, Dkt. No. 9350'' on your comment. Your comment--including your name and your state--will be placed... file a comment through that Web site. If you file your comment on paper, write ``Graco, Dkt. No. 9350...

  7. Some comments about the use of J1 integral criterion

    International Nuclear Information System (INIS)

    Roche, Roland.

    1977-01-01

    Use of J 1 integral criterion in Post Yield Fracture Mechanics is considered. If J 1 is path independent, it can be considered as a crack tip singularity characterization and then, as a good criterion for crack initiation. But it is not proved that J 1 is path independent in general case. The current practice is to consider a material with a mechanical potential energy, it is to say to suppose that strain energy W is only function of the state of strain, but not of the loading history. It is possible to introduce the defect vector concept (or driving force). The resultants of defect vectors included inside a volume are the surface integrals J vector and L vector. So the general condition for J 1 path indepedence can be written. It seems that J 1 is path independent for radial loading but the question is still open for more complex ways of loading. What is the effect of material memory on the J 1 path dependence [fr

  8. Closed expressions for specific massive multiloop self-energy integrals

    International Nuclear Information System (INIS)

    Berends, F.A.; Boehm, M.; Buza, M.; Scharf, R.

    1994-01-01

    In this paper the class of N loop massive scalar self-energy diagrams with N + 1 propagators is studied in an arbitrary number of dimensions. As it is known these integrals cannot be expressed in terms of polylogarithms. Here it is shown, however, that they can be described by generalized hypergeometric functions of several variables, namely Laricella functions. These results represent previous small and large momentum expansions in closed form. Numerical comparisons for the finite part in four dimensions with a two-dimensional integral representation show good agreement. (orig.)

  9. Proposed standby gasoline rationing plan: public comments

    Energy Technology Data Exchange (ETDEWEB)

    1978-12-01

    Under the proposed plan, DOE would allocate ration rights (rights to purchase gasoline) to owners of registered vehicles. All vehicles in a given class would receive the same entitlement. Essential services would receive supplemental allotments of ration rights as pririty firms. Once every 3 months, ration checks would be mailed out to all vehicle registrants, allotting them a certain amount of ration rights. These checks would then be cashed at Coupon Issuance Points, where the bearer would receive ration coupons to be used at gasoline stations. Large users of gasoline could deposit their allotment checks in accounts at ration banks. Coupons or checks would be freely exchangeable in a white market. A certain percentage of the gasoline supply would be set aside in reserve for use in national emergencies. When the plan was published in the Federal Register, public comments were requested. DOE also solicited comments from private citizens, public interest groups, business and industry, state and local governments. A total of 1126 responses were reveived and these are analyzed in this paper. The second part of the report describes how the comments were classified, and gives a statistical breakdown of the major responses. The last section is a discussion and analysis of theissue raised by commenting agencies, firms, associations, and individuals. (MCW)

  10. Comments by the Quebec Union for Nature Conservation (UQCN) regarding the proposed law on the security of dams

    International Nuclear Information System (INIS)

    Belanger, M.

    1998-09-01

    The Union quebecoise pour la conservation de la nature (UQCN) is an association of 5000 members that is active in the field of nature conservation and environmental protection. Comments made by the UQCN to the Parliamentary Commission on Transport and the Environment on the proposed law on the security of dams are summarized. A number of general and specific comments were made concerning access to information, the process of authorisation, and the definition of high-volume dams. Concern was also expressed about the lack of clear indication of how the plans for the management of dam security and water reservoirs will be coordinated among the various agencies that represent the various users of the river system

  11. Notes on integral identities for 3d supersymmetric dualities

    Science.gov (United States)

    Aghaei, Nezhla; Amariti, Antonio; Sekiguchi, Yuta

    2018-04-01

    Four dimensional N=2 Argyres-Douglas theories have been recently conjectured to be described by N=1 Lagrangian theories. Such models, once reduced to 3d, should be mirror dual to Lagrangian N=4 theories. This has been numerically checked through the matching of the partition functions on the three sphere. In this article, we provide an analytic derivation for this result in the A 2 n-1 case via hyperbolic hypergeometric integrals. We study the D 4 case as well, commenting on some open questions and possible resolutions. In the second part of the paper we discuss other integral identities leading to the matching of the partition functions in 3d dual pairs involving higher monopole superpotentials.

  12. Rehabilitation-specific challenges and advantages in the integration of migrant physicians in Germany: a multiperspective qualitative interview study in rehabilitative settings.

    Science.gov (United States)

    Jansen, E; Hänel, P; Klingler, C

    2018-07-01

    In Germany, rehabilitative healthcare institutions increasingly rely on migrant physicians to meet their staffing needs. Yet until now, research on the integration of migrant physicians has focussed entirely on the acute care setting. This study is the first to address the specific advantages and challenges to integration in the field of rehabilitative medicine where a high number of migrant physicians work. From the experiences of migrant physicians and their colleagues, we provide actionable suggestions to counteract potential sources of conflict and thereby improve the integration of migrant physicians in the German workforce. We conducted a qualitative interview study. We conducted 23 interviews with a total of 26 participants occupying a variety of roles in two different rehabilitation centres (maximum variation sampling). Interviews were recorded, transcribed verbatim and parsed through thematic analysis. Our research revealed advantages and challenges to integration in three distinct areas: rehabilitative care institutions, competencies of migrant professionals and interpersonal relations. The first set of issues hinges on the work processes within rehabilitative hospitals, professional prospects there and the location of the institutions themselves. Second, migrant physicians may encounter difficulties because of limited linguistic skills and country-specific knowledge. And finally, aspects of their interactions with care teams and patients may constitute barriers to integration. Some of the factors influencing the integration of migrant physicians are the same in both rehabilitative and acute medicine, but the rehabilitative setting presents distinct advantages and challenges that are worthy of study in their own right. We outline several measures which could help overcome challenges to the integration of migrant physicians, including those associated with professional relationships. Further research is needed to develop concrete support programmes

  13. 77 FR 33745 - Proposed Information Collection Activity; Comment Request

    Science.gov (United States)

    2012-06-07

    ... Information Collection Activity; Comment Request Proposed Projects Title: Native Employment Works (NEW) Program Plan Guidance and Report Requirements. OMB No.: 0970-0174. Description The Native Employment Works... collection techniques or other forms of information technology. Consideration will be given to comments and...

  14. 78 FR 21603 - Proposed Reporting Entity; Request for Comments

    Science.gov (United States)

    2013-04-11

    ... FEDERAL ACCOUNTING STANDARDS ADVISORY BOARD Proposed Reporting Entity; Request for Comments AGENCY... seeking input on a proposed Statement of Federal Financial Accounting Standards addressing the Reporting Entity. The Standard is available at http://www.fasab.gov/board-activities/documents-for-comment/exposure...

  15. 75 FR 29366 - Agency Information Collection Activities: Comment Request

    Science.gov (United States)

    2010-05-25

    ... researchers on CD-ROM and on the World Wide Web. The National Opinion Research Center (NORC) at the University... NATIONAL SCIENCE FOUNDATION Agency Information Collection Activities: Comment Request AGENCY: National Science Foundation. ACTION: Notice and request for comments. SUMMARY: The National Science...

  16. 78 FR 73872 - Agency Information Collection Activities: Proposed Collection; Comment Request; Logistics...

    Science.gov (United States)

    2013-12-09

    ...; Logistics Capability Assistance Tool (LCAT) AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice... Reduction Act of 1995, this notice seeks comments concerning the Logistics Capability Assistance Tool (LCAT... submitting comments. (2) Mail. Submit written comments to Docket Manager, Office of Chief Counsel, DHS/FEMA...

  17. 78 FR 35942 - Proposed Collection; Comment Request: Palliative Care: Conversations Matter Evaluation

    Science.gov (United States)

    2013-06-14

    ... of Management and Budget (OMB) for review and approval. Written comments and/or suggestions from the... instruments, submit comments in writing, or request more information on the proposed project, contact Ms...) 496-0256, or Email your request, including your address to: [email protected] . Comments...

  18. 78 FR 341 - Proposed Information Collection; Comment Request

    Science.gov (United States)

    2013-01-03

    ... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the... all written comments to Bureau of the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity to make comments online is also...

  19. On-line reputation systems : the effects of feedback comments and reactions on building and rebuilding trust in on-line auctions

    NARCIS (Netherlands)

    Utz, S.; Matzat, U.; Snijders, C.C.P.

    2009-01-01

    Previous research on reputation systems primarily focused on their trust-building function. The present research addresses their trust-rebuilding function-specifically, the role of the short text comments given in reaction to negative feedback. Rebuilding trust is often necessary because on-line

  20. 75 FR 64301 - Commission Information Collection Activities (FERC-537); Comment Request; Extension

    Science.gov (United States)

    2010-10-19

    ... receipt of eFiled comments. Commenters making an eFiling should not make a paper filing. Commenters that... engineering design verification and safety determination; Commercial and economic data presenting the basis... information on those who are to respond, including the use of appropriate automated, electronic, mechanical...

  1. 75 FR 52752 - Request for Comments on Synthetic Biology

    Science.gov (United States)

    2010-08-27

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Request for Comments on Synthetic Biology AGENCY... Bioethical Issues is requesting public comment on the emerging science of synthetic biology, including its... Commission has begun an inquiry into the emerging science of synthetic biology. The President asked the...

  2. 75 FR 29367 - Agency Information Collection Activities: Comment Request

    Science.gov (United States)

    2010-05-25

    ... researchers on CD-ROM and on the World Wide Web. The Bureau of the Census, as in the past, will conduct the... NATIONAL SCIENCE FOUNDATION Agency Information Collection Activities: Comment Request AGENCY: National Science Foundation. ACTION: Submission for OMB review; comment request. SUMMARY: The National...

  3. Extracting the Discussion Structure in Comments on News-Articles

    NARCIS (Netherlands)

    Schuth, A.; Marx, M.; de Rijke, M.

    2007-01-01

    Several on-line daily newspapers offer readers the opportunity to directly comment on articles. In the Netherlands this feature is used quite often and the quality (grammatically and content-wise) is surprisingly high. We develop techniques to collect, store, enrichand analyze these comments. After

  4. 77 FR 18247 - Request for Comments on Issues of Privacy and Access With Regard to Human Genome Sequence Data

    Science.gov (United States)

    2012-03-27

    ... regards genomic information and evolving notions of privacy, as evidenced and influenced by social media... Presidential Commission for the Study of Bioethical Issues is requesting public comment on the ethical issues.... Undertaking these duties, the Commission seeks to identify and examine specific bioethical, legal, and social...

  5. Development of Integral Effect Test Facility P and ID and Technical Specification for SMART Fluid System

    International Nuclear Information System (INIS)

    Lee, Sang Il; Jung, Y. H.; Yang, H. J.; Song, S. Y.; Han, O. J.; Lee, B. J.; Kim, Y. A.; Lim, J. H.; Park, K. W.; Kim, N. G.

    2010-01-01

    SMART integral test loop is the thermal hydraulic test facility with a high pressure and temperature for simulating the major systems of the prototype reactor, SMART-330. The objective of this project is to conduct the basic design for constructing SMART ITL. The major results of this project include a series of design documents, technical specifications and P and ID. The results can be used as the fundamental materials for making the detailed design which is essential for manufacturing and installing SMART ITL

  6. 76 FR 47183 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Extension

    Science.gov (United States)

    2011-08-04

    ... parties may file a comment online or on paper, by following the instructions in the Request for Comment... No. P084401'' on your comment, and file your comment online at https://ftcpublic.commentworks.com/ftc... Funeral Rule should be addressed to Craig Tregillus, Attorney, Division of Marketing Practices, Bureau of...

  7. 78 FR 22876 - Agency Information Collection Activities; Comment Request

    Science.gov (United States)

    2013-04-17

    ... EXPORT-IMPORT BANK [Public Notice 2013-0112] Agency Information Collection Activities; Comment Request AGENCY: Export-Import Bank of the United States. ACTION: Submission for OMB review and comments... Export-Import Bank of the United States (Ex-Im Bank), as a part of its continuing effort to reduce...

  8. 78 FR 1859 - Agency Information Collection Activities: Comment Request

    Science.gov (United States)

    2013-01-09

    ... EXPORT-IMPORT BANK [Public Notice 2013-0101] Agency Information Collection Activities: Comment Request AGENCY: Export-Import Bank of the United States. ACTION: Submission for OMB Review and Comments... Insurance Policy SUMMARY: The Export-Import Bank of the United States (Ex-Im Bank), as a part of its...

  9. 27 CFR 13.62 - Third-party comment on certificates.

    Science.gov (United States)

    2010-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING PROCEEDINGS Miscellaneous § 13.62 Third-party comment... agency, an industry association, a competitor of a certificate holder, a consumer or consumer group, or..., certificate of exemption from label approval, or distinctive liquor bottle approval, such comments should be...

  10. Comment on: Path integral solution of the Schroedinger equation in curvilinear coordinates: A straightforward procedure [J. Math. Phys. 37, 4310 endash 4319 (1996)

    International Nuclear Information System (INIS)

    Wurm, A.; LaChapelle, J.

    1997-01-01

    The authors comment on the paper by J. LaChapelle, J. Math. Phys. 37, 4310 (1996), and give explicit expressions for the parametrization, its solution, and the Lie derivatives of the Schroedinger equation for the case of n-dimensional spherical coordinates

  11. A data base processor semantics specification package

    Science.gov (United States)

    Fishwick, P. A.

    1983-01-01

    A Semantics Specification Package (DBPSSP) for the Intel Data Base Processor (DBP) is defined. DBPSSP serves as a collection of cross assembly tools that allow the analyst to assemble request blocks on the host computer for passage to the DBP. The assembly tools discussed in this report may be effectively used in conjunction with a DBP compatible data communications protocol to form a query processor, precompiler, or file management system for the database processor. The source modules representing the components of DBPSSP are fully commented and included.

  12. Optimisation of technical specifications using probabilistic methods

    International Nuclear Information System (INIS)

    Ericsson, G.; Knochenhauer, M.; Hultqvist, G.

    1986-01-01

    During the last few years the development of methods for modifying and optimising nuclear power plant Technical Specifications (TS) for plant operations has received increased attention. Probalistic methods in general, and the plant and system models of probabilistic safety assessment (PSA) in particular, seem to provide the most forceful tools for optimisation. This paper first gives some general comments on optimisation, identifying important parameters and then gives a description of recent Swedish experiences from the use of nuclear power plant PSA models and results for TS optimisation

  13. Spam comments prediction using stacking with ensemble learning

    Science.gov (United States)

    Mehmood, Arif; On, Byung-Won; Lee, Ingyu; Ashraf, Imran; Choi, Gyu Sang

    2018-01-01

    Illusive comments of product or services are misleading for people in decision making. The current methodologies to predict deceptive comments are concerned for feature designing with single training model. Indigenous features have ability to show some linguistic phenomena but are hard to reveal the latent semantic meaning of the comments. We propose a prediction model on general features of documents using stacking with ensemble learning. Term Frequency/Inverse Document Frequency (TF/IDF) features are inputs to stacking of Random Forest and Gradient Boosted Trees and the outputs of the base learners are encapsulated with decision tree to make final training of the model. The results exhibits that our approach gives the accuracy of 92.19% which outperform the state-of-the-art method.

  14. 77 FR 50106 - Agency Information Collection Activities; Proposed Collection; Comment Request; Extension

    Science.gov (United States)

    2012-08-20

    ..., 2015, by that time, nine years will have passed since the Commission received the data informing its.... ADDRESSES: Interested parties may file a comment online or on paper, by following the instructions in the... file your comment on paper, mail or deliver your comment to the following address: Federal Trade...

  15. Application specific integrated circuit (ASIC) readout technologies for future ion beam analytical instruments

    Energy Technology Data Exchange (ETDEWEB)

    Whitlow, Harry J. E-mail: harry_j.whitlow@nuclear.lu.se

    2000-03-01

    New possibilities for ion beam analysis (IBA) are afforded by recent developments in detector technology which facilitate the parallel collection of data from a large number of channels. Application specific integrated circuit (ASIC) technologies, which have been widely employed for multi-channel readout systems in nuclear and particle physics, are more net-cost effective (160/channel for 1000 channels) and a more rational solution for readout of a large number of channels than afforded by conventional electronics. Based on results from existing and on-going chip designs, the possibilities and issues of ASIC readout technology are considered from the IBA viewpoint. Consideration is given to readout chip architecture and how the stringent resolution, linearity and stability requirements for IBA may be met. In addition the implications of the restrictions imposed by ASIC technology are discussed.

  16. Sport Skill-Specific Expertise Biases Sensory Integration for Spatial Referencing and Postural Control.

    Science.gov (United States)

    Thalassinos, Michalis; Fotiadis, Giorgos; Arabatzi, Fotini; Isableu, Brice; Hatzitaki, Vassilia

    2017-09-15

    The authors asked how sport expertise modulates visual field dependence and sensory reweighting for controlling posture. Experienced soccer athletes, ballet dancers, and nonathletes performed (a) a Rod and Frame test and (b) a 100-s bipedal stance task during which vision and proprioception were successively or concurrently disrupted in 20-s blocks. Postural adaptation was assessed in the mean center of pressure displacement, root mean square of center of pressure velocity and ankle muscles integrated electromyography activity. Soccer athletes were more field dependent than were nonathletes. During standing, dancers were more destabilized by vibration and required more time to reweigh sensory information compared with the other 2 groups. These findings reveal a sport skill-specific bias in the reweighing of sensory inputs for spatial orientation and postural control.

  17. 76 FR 49836 - Proposed Collection; Comment Request for Form 8846

    Science.gov (United States)

    2011-08-11

    ... Actions: Lines 7 through 11 will be removed, since the passive activity limit and the carryover amounts... included in the request for OMB approval. All comments will become a matter of public record. Comments are...

  18. MUSI: an integrated system for identifying multiple specificity from very large peptide or nucleic acid data sets.

    Science.gov (United States)

    Kim, Taehyung; Tyndel, Marc S; Huang, Haiming; Sidhu, Sachdev S; Bader, Gary D; Gfeller, David; Kim, Philip M

    2012-03-01

    Peptide recognition domains and transcription factors play crucial roles in cellular signaling. They bind linear stretches of amino acids or nucleotides, respectively, with high specificity. Experimental techniques that assess the binding specificity of these domains, such as microarrays or phage display, can retrieve thousands of distinct ligands, providing detailed insight into binding specificity. In particular, the advent of next-generation sequencing has recently increased the throughput of such methods by several orders of magnitude. These advances have helped reveal the presence of distinct binding specificity classes that co-exist within a set of ligands interacting with the same target. Here, we introduce a software system called MUSI that can rapidly analyze very large data sets of binding sequences to determine the relevant binding specificity patterns. Our pipeline provides two major advances. First, it can detect previously unrecognized multiple specificity patterns in any data set. Second, it offers integrated processing of very large data sets from next-generation sequencing machines. The results are visualized as multiple sequence logos describing the different binding preferences of the protein under investigation. We demonstrate the performance of MUSI by analyzing recent phage display data for human SH3 domains as well as microarray data for mouse transcription factors.

  19. Student Practice Evaluation Form-Revised Edition online comment bank: development and reliability analysis.

    Science.gov (United States)

    Rodger, Sylvia; Turpin, Merrill; Copley, Jodie; Coleman, Allison; Chien, Chi-Wen; Caine, Anne-Maree; Brown, Ted

    2014-08-01

    The reliable evaluation of occupational therapy students completing practice education placements along with provision of appropriate feedback is critical for both students and for universities from a quality assurance perspective. This study describes the development of a comment bank for use with an online version of the Student Practice Evaluation Form-Revised Edition (SPEF-R Online) and investigates its reliability. A preliminary bank of 109 individual comments (based on previous students' placement performance) was developed via five stages. These comments reflected all 11 SPEF-R domains. A purpose-designed online survey was used to examine the reliability of the comment bank. A total of 37 practice educators returned surveys, 31 of which were fully completed. Participants were asked to rate each individual comment using the five-point SPEF-R rating scale. One hundred and two of 109 comments demonstrated satisfactory agreement with their respective default ratings that were determined by the development team. At each domain level, the intra-class correlation coefficients (ranging between 0.86 and 0.96) also demonstrated good to excellent inter-rater reliability. There were only seven items that required rewording prior to inclusion in the final SPEF-R Online comment bank. The development of the SPEF-R Online comment bank offers a source of reliable comments (consistent with the SPEF-R rating scale across different domains) and aims to assist practice educators in providing reliable and timely feedback to students in a user-friendly manner. © 2014 Occupational Therapy Australia.

  20. The convolution integral for the forward-backward asymmetry in e+e- annihilation

    International Nuclear Information System (INIS)

    Bardin, D.; Bilenky, M.; Chizhov, A.; Sazonov, A.; Sedykh, Yu.; Riemann, T.; Sachwitz, M.

    1989-01-01

    The complete convolution integral for the forward-backward asymmetry in A FB in e + e - annihilation is obtained in order O(α) with soft photon exponentiation. The influence of these QED corrections on A FB in the vicinity of the Z peak is discussed. The results are used to comment on a recent ad hoc ansatz using convolution weights derived for the total cross section. (orig.)

  1. 76 FR 5250 - Departmental Offices; Proposed Collection; Comment Request

    Science.gov (United States)

    2011-01-28

    ...: Notice and request for comments. SUMMARY: The Department of the Treasury, as part of its continuing... soliciting comments concerning Extension of Foreign Currency Form FC-1 (OMB No. 1505-0012) Weekly Consolidated Foreign Currency Report of Major Market Participants, Extension of Form FC-2 (OMB No. 1505-0010...

  2. 78 FR 13399 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-02-27

    ..., Public Law 104-13, on or after the date of publication of this notice. DATES: Comments should be received on or before March 29, 2013 to be assured of consideration. ADDRESSES: Send comments regarding the... information such as NAICS, contract and subcontract award information, and past performance. The information...

  3. 78 FR 59757 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-09-27

    ..., Public Law 104-13, on or after the date of publication of this notice. DATES: Comments should be received on or before October 28, 2013 to be assured of consideration. ADDRESSES: Send comments regarding the... carry out its contracts. Affected Public: Private Sector: Businesses or other for-profits. Estimated...

  4. Comment: Risk Allocation Norms of Civil Construction Contracts in ...

    African Journals Online (AJOL)

    This comment discusses risk allocation under Ethiopian construction law and examines risks in civil construction contracts. The comment highlights the gaps in risk allocation norms under the standard format of construction contract that was issued by the Ethiopian Ministry of Work and Urban Development (MoWUD) in 1994 ...

  5. Are biochemistry interpretative comments helpful? Results of a general practitioner and nurse practitioner survey.

    Science.gov (United States)

    Barlow, Ian M

    2008-01-01

    Adding or incorporating clinical interpretative comments on biochemistry results is widespread in UK laboratories; although this consumes considerable human resource, there is still little evidence to suggest that it is either effective or appreciated by our clinical colleagues. I therefore decided to survey our local general practitioners (GPs) and nurse practitioners to analyse whether they found biochemistry comments on reports helpful. A simple questionnaire was designed and sent to 159 GPs and 81 nurse practitioners asking them whether they found this activity useful for the limited range of test groups that we routinely comment on and also whether they would like to see commenting on more groups of tests. Overall, 49.6% of questionnaires were returned. Of these, there was overwhelming support for commenting on reports and 77% would like to see comments on a greater range of tests. Although adding clinical interpretative comments is very time-consuming for senior laboratory staff, there is overwhelming support of this activity among our GPs and nurse practitioner users; therefore, our local policy of routinely adding clinical comments will remain for the foreseeable future.

  6. Evaluation of personal integrating dosimeters

    International Nuclear Information System (INIS)

    Correa, C.A.; Bisauta, Mauricio A.

    2007-01-01

    The objective of this work is to analyze the different types of dosimeters present in the international market that are used to provide personal dose monitoring, specifically for external gamma and beta radiation, Hp(10) and Hp (0,07), as well as to add comments of advances in the field of passive and operative dosimetry, and the changes that are being produced in the regulating policy in other countries regarding the use of this devices. The technical specification of each dosimeter has been extracted of different catalogues of products. To conclude, the importance has been stressed in a proper selection of dosimeters with its advantages and disadvantages before its use. (author) [es

  7. Plasma cell-free DNA and its DNA integrity as biomarker to distinguish prostate cancer from benign prostatic hyperplasia in patients with increased serum prostate-specific antigen.

    Science.gov (United States)

    Feng, Jiang; Gang, Feng; Li, Xiao; Jin, Tang; Houbao, Huang; Yu, Cao; Guorong, Li

    2013-08-01

    To investigate whether plasma cell-free DNA (cfDNA) or its integrity could differentiate prostate cancer from benign prostate hyperplasia (BPH) in patients with serum prostate-specific antigen (PSA) ≥ 4 ng/ml. Ninety-six patients with prostate cancer and 112 patients with BPH were enrolled. cfDNA levels in plasma before prostate biopsy were quantified by real-time PCR amplification of ALU gene (product size of 115 bp), and quantitative ratio of ALU (247 bp) to ALU (115 bp) reflected the integrity of cfDNA. In patients with serum PSA ≥ 4 ng/ml, there were significant differences in plasma cfDNA or its integrity between the patients with prostate cancer (19.74 ± 4.43, 0.34 ± 0.05) and patients with BPH (7.36 ± 1.58, 0.19 ± 0.03; P Prostate cancer could be differentiated with a sensitivity of 73.2 % and a specificity of 72.7 % by cfDNA (AUC = 0.864). The integrity of cfDNA had a sensitivity of 81.7 % and a specificity of 78.8 % for the distinguishing prostate cancer from BPH (AUC = 0.910). cfDNA and its integrity could be applied to differentiate prostate cancer from BPH in patients with serum PSA ≥ 4 ng/ml.

  8. 76 FR 9025 - Agency Information Collection Activities; Proposed Collection; Comment Request; Good Laboratory...

    Science.gov (United States)

    2011-02-16

    ...; (3) equipment inspection, maintenance, calibration, and testing records; (4) documentation of feed...] Agency Information Collection Activities; Proposed Collection; Comment Request; Good Laboratory Practice... for public comment in response to the notice. This notice solicits comments on the good laboratory...

  9. A Comprehensive Definition for Integrative Oncology.

    Science.gov (United States)

    Witt, Claudia M; Balneaves, Lynda G; Cardoso, Maria J; Cohen, Lorenzo; Greenlee, Heather; Johnstone, Peter; Kücük, Ömer; Mailman, Josh; Mao, Jun J

    2017-11-01

    Integrative oncology, which is generally understood to refer to the use of a combination of complementary medicine therapies in conjunction with conventional cancer treatments, has been defined in different ways, but there is no widely accepted definition. We sought to develop and establish a consensus for a comprehensive definition of the field of integrative oncology. We used a mixed-methods approach that included a literature analysis and a consensus procedure, including an interdisciplinary expert panel and surveys, to develop a comprehensive and acceptable definition for the term "integrative oncology." The themes identified in the literature and from the expert discussion were condensed into a two-sentence definition. Survey respondents had very positive views on the draft definition, and their comments helped to shape the final version. The final definition for integrative oncology is: "Integrative oncology is a patient-centered, evidence-informed field of cancer care that utilizes mind and body practices, natural products, and/or lifestyle modifications from different traditions alongside conventional cancer treatments. Integrative oncology aims to optimize health, quality of life, and clinical outcomes across the cancer care continuum and to empower people to prevent cancer and become active participants before,during, and beyond cancer treatment." This short and comprehensive definition for the term integrative oncology will facilitate a better understanding and communication of this emerging field. This definition will also drive focused and cohesive effort to advance the field of integrative oncology. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  10. A comment on 'The Cauchy problem of f(R) gravity'

    International Nuclear Information System (INIS)

    Capozziello, S; Vignolo, S

    2009-01-01

    A critical comment on (N Lanahan-Tremblay and V Faraoni 2007 Class. Quantum Grav. 24 5667) is given discussing the well-formulation of the Chauchy problem for f(R)-gravity in metric-affine theories. (comments and replies)

  11. 77 FR 15456 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-03-15

    ..., Public Law 104-13, on or after the date of publication of this notice. DATES: Comments should be received on or before April 16, 2012 to be assured of consideration. ADDRESSES: Send comments regarding the... Transactions in, Financial Derivatives Contracts with Foreign Residents. Form: TIC Form D. Abstract: Form D is...

  12. 48 CFR 3401.501-2 - Opportunity for public comments.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Opportunity for public comments. 3401.501-2 Section 3401.501-2 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION GENERAL ED ACQUISITION REGULATION SYSTEM Agency and Public Participation 3401.501-2 Opportunity for public comments. Unless th...

  13. Confronting Prejudiced Comments: Effectiveness of a Role-Playing Exercise

    Science.gov (United States)

    Lawson, Timothy J.; McDonough, Tracy A.; Bodle, James H.

    2010-01-01

    We examined whether a role-playing exercise, similar to that developed by Plous (2000), increases students' ability to generate effective responses to prejudiced comments. We assessed social psychology students' (n = 23) ability to respond to prejudiced comments before and after the exercise, and compared their performance to that of 2 other…

  14. Understanding Public Perceptions of the HPV Vaccination Based on Online Comments to Canadian News Articles.

    Directory of Open Access Journals (Sweden)

    Yael Feinberg

    Full Text Available Given the variation in human papillomavirus (HPV vaccine coverage across Canada, and debate regarding delivery of HPV vaccines in Catholic schools, we studied online comments on Canadian news websites to understand public perceptions of HPV and HPV vaccine.We searched English- and French-language Canadian news websites for 2012 articles that contained the terms "HPV" or "human papillomavirus." Articles about HPV vaccinations that contained at least one comment were included. Two researchers independently coded comments, analyzing them for emerging themes.We identified 3073 comments from 1198 individuals in response to 71 news articles; 630 (52.6% individuals expressed positive sentiments about HPV vaccination (2.5 comments/individual, 404 (33.7% were negative (3.0 comments/individual, 34 (2.8% were mixed (1.5 comments/individual and 130 (10.8% were neutral (1.6 comments/individual. Vaccine-supportive commenters believed the vaccine is safe and effective. Common themes in negative comments included concerns regarding HPV vaccine safety and efficacy, distrust of pharmaceutical companies and government, and belief that school-age children are too young for HPV vaccine. Many comments focused on whether the Catholic Church has the right to inform health policy for students, and discussion often evolved into debates regarding HPV and sexual behaviour. We noted that many individuals doubted the credibility of vaccine safety information.The majority of commenters do not appear to be against HPV vaccination, but public health messaging that focuses on both the vaccine's safety profile, and its use as a means to prevent cancer rather than sexually transmitted HPV infection may facilitate its acceptance.

  15. 76 FR 34810 - Proposed Collection; Comment Request for Form 8810

    Science.gov (United States)

    2011-06-14

    ..., Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Form 8810, Corporate Passive Activity Loss and Credit Limitations. DATES: Written comments should be... [email protected] . [[Page 34811

  16. 78 FR 32652 - Agency Information Collections Activities: Proposed Collection; Comment Request

    Science.gov (United States)

    2013-05-31

    ... descriptive and inferential techniques appropriate to answering questions about outcomes and impacts..., Bureau of Labor Statistics. Request for Comments In accordance with the Paperwork Reduction Act, comments...

  17. 76 FR 2395 - Agency Information Collection Activities; Proposed Collection; Comment Request; Customer/Partner...

    Science.gov (United States)

    2011-01-13

    ... comment in response to the notice. This notice solicits comments on voluntary customer satisfaction...] Agency Information Collection Activities; Proposed Collection; Comment Request; Customer/Partner Service... collection of information they conduct or sponsor. ``Collection of information'' is defined in 44 U.S.C. 3502...

  18. 77 FR 8260 - Agency Information Collection Activities; Proposed Collection; Comment Request; Medical Device...

    Science.gov (United States)

    2012-02-14

    ... will be used to evaluate risks associated with medical devices which will enable FDA to take...] Agency Information Collection Activities; Proposed Collection; Comment Request; Medical Device Reporting... comment in response to the notice. This notice solicits comments on medical device reporting (MDR...

  19. Review of specific radiological accident considerations

    International Nuclear Information System (INIS)

    Elder, J.

    1984-01-01

    Specific points of guidance provided in the forthcoming document A Guide to Radiological Accident Considerations for Siting and Design of Nonreactor Nuclear Facilities are discussed. Of these, the following are considered of particular interest to analysts of hypothetical accidents: onsite dose limits; population dose, public health effects, and environmental contamination as accident consequences which should be addressed; risk analysis; natural phenomena as accident initiators; recommended dose models; multiple organ equivalent dose; and recommended methods and parameters for source terms and release amount calculations. Comments are being invited on this document, which is undergoing rewrite after the first stage of peer review

  20. 76 FR 43381 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2011-07-20

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... Financial Asset Securitization Investment Trusts; Real Estate Mortgage Investment Conduits (TD 9004 (final...

  1. 78 FR 39829 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-07-02

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments...: Title: Reporting of Nonpayroll Withheld Tax Liabilities. OMB Number: 1545-1413. Regulation Project...

  2. Comment on id-based remote data integrity checking with data privacy preserving

    Science.gov (United States)

    Zhang, Jianhong; Meng, Hongxin

    2017-09-01

    Recently, an ID-based remote data integrity checking protocol with perfect data privacy preserving (IEEE Transactions on Information Forensics and Security, doi: 10.1109/TIFS.2016.2615853) was proposed to achieve data privacy protection and integrity checking. Unfortunately, in this letter, we demonstrate that their protocol is insecure. An active hacker can modify the stored data without being detected by the verifier in the auditing. And we also show malicious cloud server can convince the verifier that the stored data are kept intact after the outsourced data blocks are deleted. Finally, the reasons to produce such attacks are given.

  3. Retroviral integration: Site matters

    Science.gov (United States)

    Demeulemeester, Jonas; De Rijck, Jan

    2015-01-01

    Here, we review genomic target site selection during retroviral integration as a multistep process in which specific biases are introduced at each level. The first asymmetries are introduced when the virus takes a specific route into the nucleus. Next, by co‐opting distinct host cofactors, the integration machinery is guided to particular chromatin contexts. As the viral integrase captures a local target nucleosome, specific contacts introduce fine‐grained biases in the integration site distribution. In vivo, the established population of proviruses is subject to both positive and negative selection, thereby continuously reshaping the integration site distribution. By affecting stochastic proviral expression as well as the mutagenic potential of the virus, integration site choice may be an inherent part of the evolutionary strategies used by different retroviruses to maximise reproductive success. PMID:26293289

  4. Comments on ‘Improving the speed of decimal division’

    DEFF Research Database (Denmark)

    Lang, T.; Nannarelli, Alberto

    2012-01-01

    For original article see Kaivani, et al., ibid, vol. 5, pp. 393-404 (2011). Lang and Nannarelli comment on the paper of Kaivani, et al., which reported a proposed unit ~46% faster than the unit from their study. Lang and Nannarelli show in this comment that the evaluation done by Kaivani, et al. ...

  5. B827 Chemical Synthhesis Project - Industrial Control System Integration - Statement of Work & Specification with Attachments 1-14

    Energy Technology Data Exchange (ETDEWEB)

    Wade, F. E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-04-21

    The Chemical Synthesis Pilot Process at the Lawrence Livermore National Laboratory (LLNL) Site 300 827 Complex will be used to synthesize small quantities of material to support research and development. The project will modernize and increase current capabilities for chemical synthesis at LLNL. The primary objective of this project is the conversion of a non-automated hands-on process to a remoteoperation process, while providing enhanced batch process step control, stored recipe-specific parameter sets, process variable visibility, monitoring, alarm and warning handling, and comprehensive batch record data logging. This Statement of Work and Specification provides the industrial-grade process control requirements for the chemical synthesis batching control system, hereafter referred to as the “Control System” to be delivered by the System Integrator.

  6. Superconducting Super Collider: Final environmental impact statement: Volume 2, Comment/response document: Summary and index

    International Nuclear Information System (INIS)

    1988-12-01

    This volume is divided into five parts as follows: Summary and Index; Letters submitted by commenters in response to the Draft Environmental Impact Statement (DEIS) from date of issue through October 17, 1988; Transcripts of testimony at the public hearings conducted by the DOE in the vicinity of each site alternative; Letters postmarked after October 17, 1988; and Comment responses to both the letters and the testimony. This summary and index is published as a guide to the reader in reviewing this document. The summary is of the approximately 7000 comments received by the DOE from a total of about 5700 commenters. It was prepared as a general reference and guide to the readers of this volume. The Index follows the summary. The first index is an alphabetical listing of commenters (of both letters and transcripts) and indicates the number each commenter was assigned. The commenter numbers guide the reader to DOE comment responses in Volume 2B which are in numerical order

  7. Comments on the Calculations of Specific Electricity and Fuel Consumption

    DEFF Research Database (Denmark)

    Jørgensen, Kaj

    1996-01-01

    Calculation of specific consumption of electricity and fuel for model electrical vehicles (passenger cars and vans). Both the present technological level and projected future technological developments. Used as background paper for a review of the scope for electrical vehicles in Denmark, carried...

  8. 78 FR 23975 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-04-23

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... definition of a controlled foreign corporation, foreign base company income and foreign personal holding...

  9. 78 FR 39830 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-07-02

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... the Ozone Layer and on Products Containing Such Chemicals. OMB Number: 1545-1153. Regulation Project...

  10. 78 FR 70100 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-11-22

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... Nuclear Power Plant. OMB Number: 1545-1378. Regulation Project Number: TD 8580. Abstract: This regulation...

  11. 78 FR 76893 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-12-19

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments.... Regulation Project Number: REG-209626-93 (TD 8796). Abstract: These regulations provide guidance concerning...

  12. 78 FR 45614 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-07-29

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... GST Deemed Allocations. OMB Number: 1545-1892. Regulation Project Number: REG-153841-02 (TD 9208...

  13. 76 FR 7220 - Medical Device Innovation Initiative; Request for Comments

    Science.gov (United States)

    2011-02-09

    ... medical device innovation. 6. Other actions CDRH should take to facilitate the development, assessment...] Medical Device Innovation Initiative; Request for Comments AGENCY: Food and Drug Administration, HHS... availability of a document for public comment entitled ``Medical Device Innovation Initiative'' (the report...

  14. Reply to 'Comment on 'Lorentz contraction and current-carrying wires''

    International Nuclear Information System (INIS)

    Van Kampen, Paul

    2010-01-01

    This reply answers the issues raised in the Comment on my paper (van Kampen 2008 Eur. J. Phys. 29 879-83). The error of applying a single Lorentz transformation to a wire segment is discussed in some detail. (letters and comments)

  15. 78 FR 21708 - Proposed Collection; Comment Request for Publication 1345

    Science.gov (United States)

    2013-04-11

    ... Publication 1345 AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... Publication 1345, Handbook for Authorized IRS e-file Providers. DATES: Written comments should be received on... [email protected] . SUPPLEMENTARY INFORMATION: Title: Publication 1345, Handbook for Authorized...

  16. 76 FR 9406 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2011-02-17

    ... comments concerning the existing proposed regulations, REG-100194-10, Specified Tax Return Preparers Required to File Individual Income Tax Returns Using Magnetic Media--Taxpayer Choice Statements. DATES...: Direct all written comments to Yvette Lawrence, Internal Revenue Service, Room 6129, 1111 Constitution...

  17. Quality specifications in postgraduate medical e-learning: an integrative literature review leading to a postgraduate medical e-learning model.

    Science.gov (United States)

    De Leeuw, R A; Westerman, Michiel; Nelson, E; Ket, J C F; Scheele, F

    2016-07-08

    E-learning is driving major shifts in medical education. Prioritizing learning theories and quality models improves the success of e-learning programs. Although many e-learning quality standards are available, few are focused on postgraduate medical education. We conducted an integrative review of the current postgraduate medical e-learning literature to identify quality specifications. The literature was thematically organized into a working model. Unique quality specifications (n = 72) were consolidated and re-organized into a six-domain model that we called the Postgraduate Medical E-learning Model (Postgraduate ME Model). This model was partially based on the ISO-19796 standard, and drew on cognitive load multimedia principles. The domains of the model are preparation, software design and system specifications, communication, content, assessment, and maintenance. This review clarified the current state of postgraduate medical e-learning standards and specifications. It also synthesized these specifications into a single working model. To validate our findings, the next-steps include testing the Postgraduate ME Model in controlled e-learning settings.

  18. The independent review group's comments on the MPC

    International Nuclear Information System (INIS)

    Vincent, J.A.

    1994-01-01

    This article presents comments from the Group (IRG) who independently reviewed the multipurpose canister system (MCS) Conceptual Design Report. The IRG determined that its efforts would be best directed toward providing the DOE with recommendations concerning the MPC system design and development. Comments also focused on applying lessons learned during the CSDP review to the MPC design and procurement. Topics highlighted are the programmatic review and the MPC design review

  19. System/subsystem specifications for the Worldwide Port System (WPS) Regional Integrated Cargo Database (ICDB)

    Energy Technology Data Exchange (ETDEWEB)

    Rollow, J.P.; Shipe, P.C.; Truett, L.F. [Oak Ridge National Lab., TN (United States); Faby, E.Z.; Fluker, J.; Grubb, J.; Hancock, B.R. [Univ. of Tennessee, Knoxville, TN (United States); Ferguson, R.A. [Science Applications International Corp., Oak Ridge, TN (United States)

    1995-11-20

    A system is being developed by the Military Traffic Management Command (MTMC) to provide data integration and worldwide management and tracking of surface cargo movements. The Integrated Cargo Database (ICDB) will be a data repository for the WPS terminal-level system, will be a primary source of queries and cargo traffic reports, will receive data from and provide data to other MTMC and non-MTMC systems, will provide capabilities for processing Advance Transportation Control and Movement Documents (ATCMDs), and will process and distribute manifests. This System/Subsystem Specifications for the Worldwide Port System Regional ICDB documents the system/subsystem functions, provides details of the system/subsystem analysis in order to provide a communication link between developers and operational personnel, and identifies interfaces with other systems and subsystems. It must be noted that this report is being produced near the end of the initial development phase of ICDB, while formal software testing is being done. Following the initial implementation of the ICDB system, maintenance contractors will be in charge of making changes and enhancing software modules. Formal testing and user reviews may indicate the need for additional software units or changes to existing ones. This report describes the software units that are components of this ICDB system as of August 1995.

  20. The quartet theory: Implications for autism spectrum disorder. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Pehrs, Corinna; Samson, Andrea C.; Gross, James J.

    2015-06-01

    Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by social and communication deficits as well as restricted and repetitive behaviors [1]. Specific deficits include failure to initiate reciprocal social interactions, verbal and non-verbal communication difficulties, decreased sensitivity to social and emotional cues, and limited perspective-taking abilities. Social withdrawal, avoidance or indifference to affection or physical contact, lack of eye contact, and decreased joint attention and facial responsiveness are also common [2]. In addition to these core features, there is a growing body of literature that describes problematic patterns of emotional reactivity (increased negative and decreased positive emotions) and emotion regulation (increased use of maladaptive and decreased use of adaptive emotion regulation strategies) [3-5]. The present comment seeks to link difficulties in socio-emotional domains to the Quartet Theory of Human Emotions by mapping characteristic ASD social deficits and emotion dysregulation onto two of the affect systems described in this theory: the hippocampal and orbitofrontal-centered systems.

  1. 78 FR 66350 - Commission Information Collection Activities (FERC-574); Comment Request

    Science.gov (United States)

    2013-11-05

    ... State Commission is exercising that jurisdiction. 18 CFR Part 152 specifies the data required to be... Cost per FTE, including salary + benefits. Comments: Comments are invited on: (1) Whether the...

  2. 77 FR 29391 - An Approach for Probabilistic Risk Assessment in Risk-Informed Decisions on Plant-Specific...

    Science.gov (United States)

    2012-05-17

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0110] An Approach for Probabilistic Risk Assessment in Risk-Informed Decisions on Plant-Specific Changes to the Licensing Basis AGENCY: Nuclear Regulatory Commission. ACTION: Draft regulatory guide; request for comment. SUMMARY: The U.S. Nuclear Regulatory...

  3. 14 CFR 11.75 - Does FAA invite public comment on petitions for rulemaking?

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Does FAA invite public comment on petitions... Rulemaking and for Exemption § 11.75 Does FAA invite public comment on petitions for rulemaking? Generally, FAA does not invite public comment on petitions for rulemaking. ...

  4. 78 FR 46347 - Agency Information Collection Activities; Proposed Collection; Comment Request; Medical Devices...

    Science.gov (United States)

    2013-07-31

    ... Good Manufacturing Practice Quality System Regulation AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing an opportunity for public comment... information, and to allow 60 days for public comment in response to the notice. This notice solicits comments...

  5. 78 FR 28851 - Agency Information Collection Activities; Proposed Collection; Comment Request; Guidance for...

    Science.gov (United States)

    2013-05-16

    ...: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing an opportunity for public comment... information, and to allow 60 days for public comment in response to the notice. This notice solicits comments... Submission System to Submit Information in Electronic Format using the FDA Electronic Submissions Gateway...

  6. 78 FR 73192 - Agency Information Collection Activities; Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-12-05

    ... the relationship continues. Staff's estimates assume that the affiliate marketing opt-out will be... collection requirements in its Affiliate Marketing Rule (or ``Rule''), which applies to certain motor vehicle... Marketing Disclosure Rule, PRA Comment: FTC File No. P0105411'' on your comment, and file your comment...

  7. Background Information for the Nevada National Security Site Integrated Sampling Plan, Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Farnham, Irene; Marutzky, Sam

    2014-12-01

    This document describes the process followed to develop the Nevada National Security Site (NNSS) Integrated Sampling Plan (referred to herein as the Plan). It provides the Plan’s purpose and objectives, and briefly describes the Underground Test Area (UGTA) Activity, including the conceptual model and regulatory requirements as they pertain to groundwater sampling. Background information on other NNSS groundwater monitoring programs—the Routine Radiological Environmental Monitoring Plan (RREMP) and Community Environmental Monitoring Program (CEMP)—and their integration with the Plan are presented. Descriptions of the evaluations, comments, and responses of two Sampling Plan topical committees are also included.

  8. 78 FR 24814 - Proposed Collection; Comment Request for Form 8612

    Science.gov (United States)

    2013-04-26

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Form 8612 AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments. SUMMARY... 8612, Return of Excise Tax on Undistributed Income of Real Estate Investment Trusts. DATES: Written...

  9. 75 FR 33887 - Proposed Collection; Comment Request for Form 8612

    Science.gov (United States)

    2010-06-15

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Form 8612 AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments. SUMMARY... 8612, Return of Excise Tax on Undistributed Income of Real Estate Investment Trusts. DATES: Written...

  10. 78 FR 26694 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-05-07

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments. SUMMARY: The Department of the Treasury, as part of its continuing effort to reduce paperwork and...

  11. 78 FR 76892 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-12-19

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... Liabilities for Pension Funding Purposes. OMB Number: 1545-2095. Regulation Project Number: REG-139236-07 (TD...

  12. 76 FR 74117 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2011-11-30

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... Number: 1545-0817. Regulation Project Number: EE-28-78 (TD 7845). Abstract: Internal Revenue Code section...

  13. 78 FR 39832 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-07-02

    ..., return requirements, definitions, and certain rules covering the generation-skipping transfer tax. The... generation-skipping transfer tax. DATES: Written comments should be received on or before September 3, 2013 to be assured of consideration. ADDRESSES: Direct all written comments to Yvette Lawrence, Internal...

  14. 75 FR 29817 - Proposed Collection; Comment Request for Publication 1345

    Science.gov (United States)

    2010-05-27

    ... Publication 1345 AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... Publication 1345, Handbook for Authorized IRS e-file Providers. DATES: Written comments should be received on....gov . SUPPLEMENTARY INFORMATION: Title: Publication 1345, Handbook for Authorized IRS e-file Providers...

  15. 75 FR 8315 - Submission for OMB Review; Comment Request; Correction

    Science.gov (United States)

    2010-02-24

    ..., a 30-day public comment period notice will be published. The Acting Director, Information Collection... published a 30-day comment period notice in the Federal Register (Page 7264, Column 3) seeking public.... James Hyler, Acting Director, Information Collection Clearance Division, Regulatory Information...

  16. 78 FR 17183 - Information Collection: Grey Towers Visitor Comment Card

    Science.gov (United States)

    2013-03-20

    ... DEPARTMENT OF AGRICULTURE Forest Service Information Collection: Grey Towers Visitor Comment Card... request: (1) An extension from the Office of Management and Budget; and (2) to merge the currently approved information collection 0596- 0222, ``Grey Towers Visitor Comment Card'' with 0596-0226, ``Forest...

  17. How to respond to referee comments for scientific articles?

    Science.gov (United States)

    Kalemci, Mustafa Serdar; Turna, Burak

    2013-09-01

    Currently, the increasing number of article submissions to scientific journals forces editors to be more selective in their acceptance of papers. Consequently, editors have increased the frequency of their use of scientific referee mechanisms. For many researchers, the publication of a scientific article in a high impact factor journal is a gradual and difficult process. After preparation and submission of a manuscript, one of the most important issue is responding to the comments of referees. However, there is a paucity of published reports in the literature describing how to respond to these comments. The aim of this review is to assist researchers/authors in responding to referee comments as part of the publication process for scientific articles.

  18. 75 FR 24501 - Fatigue Tolerance Evaluation of Metallic Structures; Extension of Comment Period

    Science.gov (United States)

    2010-05-05

    ... notice responds to a request from the European Aviation Safety Agency (EASA) to extend the comment period... comments to Docket Operations at 202-493-2251. Hand Delivery or Courier: Deliver comments to Docket... Federal holidays. FOR FURTHER INFORMATION CONTACT: Minh-Hai Tran-Lam, ARM-207, Office of Rulemaking...

  19. 77 FR 72830 - Request for Comments on Request for Continued Examination (RCE) Practice

    Science.gov (United States)

    2012-12-06

    ... submission of written comments by electronic mail message over the Internet or by postal mail; (2) through... February 4, 2013. ADDRESSES: Comments should be sent by electronic mail message over the Internet addressed... submitted by postal mail, the Office prefers to receive comments by electronic mail message over the...

  20. United Kingdom comments on INFCE/DEP./WG-4/72

    International Nuclear Information System (INIS)

    1978-11-01

    This document presents comments prepared by the UK delegation upon INFCE/DEP./WG-4/72. It details differences in approach to the ALARA concept between the US and the UK and comments on the figures presented for occupational and general public radiation exposure in the context of the THORP plant to be constructed at Windscale, UK

  1. Integrated power-saving motor for power-demands of less than one kilowatt; Integral-Sparmotor im Leistungsbereich < 1 kW

    Energy Technology Data Exchange (ETDEWEB)

    Lindegger, M.; Kreuzer, H.H.; Lischer, G.

    2005-10-15

    This annual report for the Swiss Federal Office of Energy (SFOE) takes a look at the results of the second phase of a project concerning the development of integrated energy-saving electrical motors in the power range less than one kilowatt. The search for industrial partners is commented on and the publishing of an initial functional prototype on the Internet is mentioned. Participation at various fairs and the publication of articles in the technical press are mentioned. Further work on the motor is described, as is development work done on the drive electronics and the associated software. Further work planned is described.

  2. They Came, They Liked, They Commented: Social Influence on Facebook News Channels.

    Science.gov (United States)

    Winter, Stephan; Brückner, Caroline; Krämer, Nicole C

    2015-08-01

    Due to the increasing importance of social networking sites as sources of information, news media organizations have set up Facebook channels in which they publish news stories or links to articles. This research investigated how journalistic texts are perceived in this new context and how reactions of other users change the influence of the main articles. In an online experiment (N=197), a Facebook posting of a reputable news site and the corresponding article were shown. The type of user comments and the number of likes were systematically varied. Negative comments diminished the persuasive influence of the article, while there were no strengthening effects of positive comments. When readers perceived the topic as personally relevant, comments including relevant arguments were more influential than comments with subjective opinions, which can be explained by higher levels of elaboration. However, against expectations of bandwagon perceptions, a high number of likes did not lead to conformity effects, which suggests that exemplifying comments are more influential than statistical user representations. Results are discussed with regard to effects of news media content and the mechanisms of social influence in Web 2.0.

  3. Technical specification for fabrication of HANARO pool cover

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Jeong Soo; Woo, Sang Ik

    2001-06-01

    This technical specification details the requirements and the acceptance criteria for design, seismic analysis, function test, installation and quality assurance for HANARO pool cover which will be installed at the top of reactor pool. The pool cover is classified as non-nuclear safety, seismic category II and quality class T. The basic design of the pool cover for increasing HANARO applications has been carried out for supporting the driving devices which can load, unload and rotate the irradiation targets in the in-core and out-core vertical irradiation holes under on-power operation. The comments of HANARO user group related with irradiation tests have optimally considered in the process of design. The interference between fuel handling and control absorber units in the reactor pool and activities to load, unload and rotate the irradiation targets at the top of the reactor pool have been minimized. The pool cover can be moved for maintenance and can protect the reactor pool from unexpected drop of foreign materials. It provides the space to vertical access of driving devices for NTD, CT/IR and OR4/OR5 under on-power operation. And the pool cover assembly must maintain its structural integrity under seismic load. Based on the above design concept, the HANARO pool cover has been proposed as supporting structure of driving devices for NTD, fission moly and RI production under on-power operation.

  4. 77 FR 64379 - Proposed Collection; Comment Request for Form 1000

    Science.gov (United States)

    2012-10-19

    ... 1000 AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments. SUMMARY... 1000, Ownership Certificate. DATES: Written comments should be received on or before December 18, 2012...: Ownership Certificate. OMB Number: 1545-0054. Form Number: 1000. Abstract: Form 1000 is used by citizens...

  5. 76 FR 24537 - Paperwork Reduction Act; Proposed Collection; Comment Request

    Science.gov (United States)

    2011-05-02

    ... President, Office of National Drug Control Policy, Drug-Free Communities (DFC) Support Program, 750 17th... OFFICE OF NATIONAL DRUG CONTROL POLICY Paperwork Reduction Act; Proposed Collection; Comment Request AGENCY: Office of National Drug Control Policy. ACTION: 60-Day notice and request for comments...

  6. 78 FR 41192 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-07-09

    ... definitions; excise tax returns. DATES: Written comments should be received on or before September 9, 2013 to be assured of consideration. ADDRESSES: Direct all written comments to Yvette Lawrence, Internal... definitions; excise tax returns. OMB Number: 1545-2193. Regulation Project Number: REG-155087-05. Abstract...

  7. 76 FR 77051 - Proposed Collection; Comment Request for Form 5452

    Science.gov (United States)

    2011-12-09

    ..., Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Form 5452, Corporate Report of Nondividend Distributions. DATES: Written comments should be received on or....gov . SUPPLEMENTARY INFORMATION: Title: Corporate Report of Nondividend Distributions. OMB Number...

  8. 75 FR 60508 - Proposed Collection: Comment Request for Regulation Project

    Science.gov (United States)

    2010-09-30

    ... ``direct rollover'' transaction. These provisions also require qualified pension plans and tax-sheltered... comments concerning an existing final regulation, EE-43-92 (TD 8619), Direct Rollovers and 20- Percent... November 29, 2010 to be assured of consideration. ADDRESSES: Direct all written comments to Gerald Shields...

  9. 76 FR 69329 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2011-11-08

    ... collection requirements related to Tax Shelter Regulations. DATES: Written comments should be received on or before January 9, 2012 to be assured of consideration. ADDRESSES: Direct all written comments to Yvette B... . SUPPLEMENTARY INFORMATION: Title: Tax Shelter Disclosure Regulations. OMB Number: 1545-1685. Regulation Project...

  10. 77 FR 21158 - VA Directive 0005 on Scientific Integrity: Availability for Review and Comment

    Science.gov (United States)

    2012-04-09

    ... Draft VA Directive 0005 on Scientific Integrity: [square] Fosters a culture of transparency, integrity, and ethical behavior in the development and application of scientific and technological findings in VA... information from inappropriate political or commercial influence; [square] Ensures that selection and...

  11. 77 FR 58585 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Science.gov (United States)

    2012-09-21

    ...: Electronic comments to: http://www.regulations.gov and search for Docket No. NRC-2012-0190. Mail comments to... time from each applicant or individual to enable the Department of the Treasury to process electronic...

  12. 78 FR 25083 - Pleading Cycle Established for Comment on Applications for State Certification for the Provision...

    Science.gov (United States)

    2013-04-29

    ... Comment on Applications for State Certification for the Provision of Telecommunications Relay Service... is being comment upon, by any of the following methods: Electronic Filers: Comments may be filed electronically using the Internet by accessing the Commission's Electronic Comment Filing System (ECFS), through...

  13. 78 FR 15722 - Pleading Cycle Established for Comment on Applications for State Certification for the Provision...

    Science.gov (United States)

    2013-03-12

    ... Comment on Applications for State Certification for the Provision of Telecommunications Relay Service... is being comment upon, by any of the following methods: Electronic Filers: Comments may be filed electronically using the Internet by accessing the Commission's Electronic Comment Filing System (ECFS), through...

  14. 78 FR 28703 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-05-15

    ... requirements that must be met for an investment to qualify under Internal Revenue code section 936(d)(4) as an... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments...

  15. 76 FR 81541 - Request for Comments Under E.O. 12898

    Science.gov (United States)

    2011-12-28

    ..., commits agencies to develop a final Environmental Justice Strategy. The purpose of this notice is to invite public comment on DOL's draft Environmental Justice Strategy. DATES: Comments must be received on... Federal agencies to put in place procedures and take actions to make achieving environmental justice part...

  16. 75 FR 5855 - Proposed Collection; Comment Request for Form 6197

    Science.gov (United States)

    2010-02-04

    ... 6197, Gas Guzzler Tax. DATES: Written comments should be received on or before April 5, 2010 to be assured of consideration. ADDRESSES: Direct all written comments to R. Joseph Durbala, Internal Revenue... Guzzler Tax. OMB Number: 1545-0242. Form Number: 6197. Abstract: Internal Revenue Code section 4064...

  17. 76 FR 34294 - Proposed Collection; Comment Request for Form 8827

    Science.gov (United States)

    2011-06-13

    ... 8827, Credit for Prior Year Minimum Tax-Corporations. DATES: Written comments should be received on or before August 12, 2011 to be assured of consideration. ADDRESSES: Direct all written comments to Yvette B....gov . SUPPLEMENTARY INFORMATION: Title: Credit for Prior Year Minimum Tax-Corporations. OMB Number...

  18. Article

    African Journals Online (AJOL)

    lifelong learners is another feature of these innovations. The University of .... Many of the positive comments related specifically to integration of theory and practice ... attention. Additional written assignments are often experienced by students.

  19. 76 FR 45799 - Agency Information Collection Activities; Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-08-01

    ... ``Consumer Fraud Survey, Project No. P105502'' on your comment, and file your comment online at: https... heightened security screening. As a result, we encourage you to submit your comments online. To make sure... advance its understanding of the prevalence of consumer fraud and to allow the FTC to better serve people...

  20. Using a database to manage resolution of comments on standards

    International Nuclear Information System (INIS)

    Holloran, R.W.; Kelley, R.P.

    1995-01-01

    Features of production systems that would enhance development and implementation of procedures and other standards were first suggested in 1988 described how a database could provide the features sought for managing the content of structured documents such as standards and procedures. This paper describes enhancements of the database that manage the more complex links associated with resolution of comments. Displaying the linked information on a computer display aids comment resolvers. A hardcopy report generated by the database permits others to independently evaluate the resolution of comments in context with the original text of the standard, the comment, and the revised text of the standard. Because the links are maintained by the database, consistency between the agreed-upon resolutions and the text of the standard can be maintained throughout the subsequent reviews of the standard. Each of the links is bidirectional; i.e., the relationships between any two documents can be viewed from the perspective of either document

  1. 75 FR 15437 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Science.gov (United States)

    2010-03-29

    ...) hours 500 1 1.5 750 Send comments to Summer King, SAMHSA Reports Clearance Officer, Room 7-1044, One Choke Cherry Road, Rockville, MD 20857. Written comments should be received within 60 days of this...

  2. 78 FR 4983 - Proposed Information Collection; Women Veterans Healthcare Barriers Survey Activity: Comment Request

    Science.gov (United States)

    2013-01-23

    ... Veterans Healthcare Barriers Survey Activity: Comment Request AGENCY: Veterans Health Administration... Healthcare Barriers Survey'' in any correspondence. During the comment period, comments may be viewed online... of automated collection techniques or the use of other forms of information technology. Title: Women...

  3. 77 FR 68790 - Program Comment Issued for Streamlining Section 106 Review for Actions Affecting Post-1945...

    Science.gov (United States)

    2012-11-16

    ... Program Comment including: Removing reinforced concrete rigid frames, metal rigid frames, and curved metal... culverts and reinforced concrete boxes among the common bridge types covered by the Program Comment. Two... Program Comment: Program Comment for Common Post-1945 Concrete and Steel Bridges I. Introduction Every...

  4. Simultaneous inference of phenotype-associated genes and relevant tissues from GWAS data via Bayesian integration of multiple tissue-specific gene networks.

    Science.gov (United States)

    Wu, Mengmeng; Lin, Zhixiang; Ma, Shining; Chen, Ting; Jiang, Rui; Wong, Wing Hung

    2017-12-01

    Although genome-wide association studies (GWAS) have successfully identified thousands of genomic loci associated with hundreds of complex traits in the past decade, the debate about such problems as missing heritability and weak interpretability has been appealing for effective computational methods to facilitate the advanced analysis of the vast volume of existing and anticipated genetic data. Towards this goal, gene-level integrative GWAS analysis with the assumption that genes associated with a phenotype tend to be enriched in biological gene sets or gene networks has recently attracted much attention, due to such advantages as straightforward interpretation, less multiple testing burdens, and robustness across studies. However, existing methods in this category usually exploit non-tissue-specific gene networks and thus lack the ability to utilize informative tissue-specific characteristics. To overcome this limitation, we proposed a Bayesian approach called SIGNET (Simultaneously Inference of GeNEs and Tissues) to integrate GWAS data and multiple tissue-specific gene networks for the simultaneous inference of phenotype-associated genes and relevant tissues. Through extensive simulation studies, we showed the effectiveness of our method in finding both associated genes and relevant tissues for a phenotype. In applications to real GWAS data of 14 complex phenotypes, we demonstrated the power of our method in both deciphering genetic basis and discovering biological insights of a phenotype. With this understanding, we expect to see SIGNET as a valuable tool for integrative GWAS analysis, thereby boosting the prevention, diagnosis, and treatment of human inherited diseases and eventually facilitating precision medicine.

  5. 14 CFR 11.85 - Does FAA invite public comment on petitions for exemption?

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Does FAA invite public comment on petitions... Rulemaking and for Exemption § 11.85 Does FAA invite public comment on petitions for exemption? Yes, FAA... the reasons for requesting it; and (e) A request for comments to assist FAA in evaluating the petition. ...

  6. Region-specific role for Pten in maintenance of epithelial phenotype and integrity

    Science.gov (United States)

    Flodby, Per; Sunohara, Mitsuhiro; Castillo, Dan R.; McConnell, Alicia M.; Krishnaveni, Manda S.; Banfalvi, Agnes; Li, Min; Stripp, Barry; Zhou, Beiyun; Crandall, Edward D.; Minoo, Parviz

    2017-01-01

    Previous studies have demonstrated resistance to naphthalene-induced injury in proximal airways of mice with lung epithelial-specific deletion of the tumor-suppressor gene Pten, attributed to increased proliferation of airway progenitors. We tested effects of Pten loss following bleomycin injury, a model typically used to study distal lung epithelial injury, in conditional PtenSFTPC-cre knockout mice. Pten-deficient airway epithelium exhibited marked hyperplasia, particularly in small bronchioles and at bronchoalveolar duct junctions, with reduced E-cadherin and β-catenin expression between cells toward the luminal aspect of the hyperplastic epithelium. Bronchiolar epithelial and alveolar epithelial type II (AT2) cells in PtenSFTPC-cre mice showed decreased expression of epithelial markers and increased expression of mesenchymal markers, suggesting at least partial epithelial-mesenchymal transition at baseline. Surprisingly, and in contrast to previous studies, mutant mice were exquisitely sensitive to bleomycin, manifesting rapid weight loss, respiratory distress, increased early mortality (by day 5), and reduced dynamic lung compliance. This was accompanied by sloughing of the hyperplastic airway epithelium with occlusion of small bronchioles by cellular debris, without evidence of increased parenchymal lung injury. Increased airway epithelial cell apoptosis due to loss of antioxidant defenses, reflected by decreased expression of superoxide dismutase 3, in combination with deficient intercellular adhesion, likely predisposed to airway sloughing in knockout mice. These findings demonstrate an important role for Pten in maintenance of airway epithelial phenotype integrity and indicate that responses to Pten deletion in respiratory epithelium following acute lung injury are highly context-dependent and region-specific. PMID:27864284

  7. Reply to ''Comment on 'Thermocouple temperature measurements in shock-compressed solids' ''

    International Nuclear Information System (INIS)

    Bloomquist, D.D.; Sheffield, S.A.

    1982-01-01

    We disagree with the interpretation offered in the above comment. The suggestion was made that the anomalously fast response of thin-foil thermocouples reported previously is the result of strain dependence of the thermocouple response and not shock enhanced thermal equilibration. Although the emplacement geometry has a profound effect on the response of embedded thin-foil temperature gauges as noted in the above comment, the evidence presented, along with recent results discussed in this reply, do not support the conclusions presented in the above comment

  8. 78 FR 10264 - Proposed Collection; Comment Request for Form 8870

    Science.gov (United States)

    2013-02-13

    ..., Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Form 8870, Information Return for Transfers Associated With Certain Personal Benefit Contracts. DATES: Written comments should be received on or before April 15, 2013 to be assured of consideration. ADDRESSES...

  9. 77 FR 58907 - Proposed Agency Information Collection Activities; Comment Request

    Science.gov (United States)

    2012-09-24

    ... hour 30 Inspector Training Reimbursement. 30 States 300 vouchers....... 1 hour 300 Annual Work Plan 30... hours 800 Quiet Zone. Authorities. --Diagnostic Team Rev........ 340 Public 2 team reviews..... 16 hours.... --Comments to FRA on Quiet 715 Railroads/State 20 comments........ 2.5 hours 30 Zone Application. Agencies...

  10. 76 FR 40774 - Proposed Collection; Comment Request for Form 8621

    Science.gov (United States)

    2011-07-11

    ... 8621, Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund. DATES... Passive Foreign Investment Company or Qualified Electing Fund. OMB Number: 1545-1002. Form Number: 8621... included in the request for OMB approval. All comments will become a matter of public record. Comments are...

  11. 76 FR 30432 - Proposed Collection; Comment Request for Form 3115

    Science.gov (United States)

    2011-05-25

    ..., Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Form 3115, Application for Change in Accounting Method. DATES: Written comments should be received on or....gov . SUPPLEMENTARY INFORMATION: Title: Application for Change in Accounting Method. OMB Number: 1545...

  12. 76 FR 27751 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2011-05-12

    ... 1995, Public Law 104-13(44 U.S.C. 3506(c)(2)(A)). The IRS is soliciting comments concerning information collection related to Limitations on Corporate Net Operating Loss. DATES: Written comments should be received... . SUPPLEMENTARY INFORMATION: Title: Limitations on Corporate Net Operating Loss. OMB Number: 1545-1381. [[Page...

  13. 78 FR 16047 - Proposed Collection; Comment Request for Form 966

    Science.gov (United States)

    2013-03-13

    ..., Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Form 966, Corporate Dissolution or Liquidation. DATES: Written comments should be received on or before May... . SUPPLEMENTARY INFORMATION: Title: Corporate Dissolution or Liquidation. OMB Number: 1545-0041. Form Number: 966...

  14. 75 FR 33670 - Proposed Collection; Comment Request for Form 2032

    Science.gov (United States)

    2010-06-14

    ..., Public Law 104-13(44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Form 2032, Contract Coverage Under Title II of the Social Security Act. DATES: Written comments should [email protected] . SUPPLEMENTARY INFORMATION: Title: Contract Coverage Under Title II of the Social...

  15. 78 FR 54512 - Proposed Collection; Comment Request for Form 720

    Science.gov (United States)

    2013-09-04

    ... 720, Quarterly Federal Excise Tax Return. DATES: Written comments should be received on or before November 4, 2013 to be assured of consideration. ADDRESSES: Direct all written comments to Yvette Lawrence...: Quarterly Federal Excise Tax Return. OMB Number: 1545-0023. Form Number: 720. Abstract: Form 720 is used to...

  16. 78 FR 35660 - Proposed Collection; Comment Request for Form 1116

    Science.gov (United States)

    2013-06-13

    ... 1116, Foreign Tax Credit. DATES: Written comments should be received on or before August 12, 2013 to be assured of consideration. ADDRESSES: Direct all written comments to Yvette Lawrence, Internal Revenue...: Foreign Tax Credit. OMB Number: 1545-0121. Form Number: 1116. Abstract: Form 1116 is used by individuals...

  17. COMTRANS, ENSDF Comment Font Case Translator

    International Nuclear Information System (INIS)

    KINSEY, Robert

    1996-01-01

    1 - Description of program or function: The program COMTRANS is a nuclear structure evaluator tool for translating comments in the Evaluated Nuclear Structures Data file (ENSDF) from the all upper case form into the currently approved upper/lower case form. Not only is the newer form easier to read but the comments no longer need to be used with a dictionary. 2 - Method of solution: The program asks for an input file name and an output file name. The input and output files may include a disk and directory path. 3 - Restrictions on the complexity of the problem: The nuclear structure data dictionary database must be in the directory from which the program is executed

  18. 77 FR 17479 - Star Pipe Products, Ltd.; Analysis of Proposed Consent Order To Aid Public Comment

    Science.gov (United States)

    2012-03-26

    ... FEDERAL TRADE COMMISSION [Docket No. 9351] Star Pipe Products, Ltd.; Analysis of Proposed Consent... ``Star Pipe, Docket No. 9351'' on your comment, and file your comment online at https://ftcpublic..., 2012. Write ``Star Pipe, Docket No. 9351'' on your comment. Your comment-- including your name and your...

  19. 76 FR 17423 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Science.gov (United States)

    2011-03-29

    ... Services Administration publishes summaries of proposed data collection projects for public comment... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Resources and Services Administration Agency Information Collection Activities: Proposed Collection; Comment Request In compliance with the requirements of...

  20. 78 FR 36197 - Request for Public Comment: 60-Day Proposed Information Collection: Application for Participation...

    Science.gov (United States)

    2013-06-17

    ... function; (b) whether the agency processes the information collected in a useful and timely fashion; (c... requests, comments, and return address to: [email protected] . Comment Due Date: Comments regarding this...

  1. The Cat and the Pigeons: Some General Comments on (TP) Tax Rulings and State Aid After the Starbucks and Fiat Decisions

    NARCIS (Netherlands)

    Wattel, P.J.; Richelle, I.; Schön, W.; Traversa, E.

    2016-01-01

    The Commission State aid decisions on individual tax rulings have created legal uncertainty, which may have been one of their goals. This article comments on their political and policy merits and effects, it wonders whether EU law requires member States to have—and apply in a certain manner—specific

  2. 77 FR 49818 - Agency Information Collection Activities; Proposed Collection; Comment Request; Bar Code Label...

    Science.gov (United States)

    2012-08-17

    ...] Agency Information Collection Activities; Proposed Collection; Comment Request; Bar Code Label... allow 60 days for public comment in response to the notice. This notice solicits comments on the bar... technology. Bar Code Label Requirement for Human Drug and Biological Products--(OMB Control Number 0910-0537...

  3. 78 FR 66670 - Housing Counseling Program: New Certification Requirements; Extension of Public Comment Period

    Science.gov (United States)

    2013-11-06

    ... Counseling Program: New Certification Requirements; Extension of Public Comment Period AGENCY: Office of the... inviting public comment on proposed changes to the Housing Counseling Program regulations for the purpose... housing counseling statute. This document announces that HUD is extending the public comment period, for...

  4. 75 FR 40031 - Proposed Collection; Comment Request for Form 3800

    Science.gov (United States)

    2010-07-13

    ..., Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Form 3800, General Business Credit. DATES: Written comments should be received on or before September 13... INFORMATION: Title: General Business Credit. OMB Number: 1545-0895. Form Number: Form 3800. Abstract: Internal...

  5. 76 FR 36620 - Proposed Collection; Comment Request for Form 4797

    Science.gov (United States)

    2011-06-22

    ..., Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Form 4797, Sales of Business Property. DATES: Written comments should be received on or before August [email protected] . SUPPLEMENTARY INFORMATION: Title: Sales of Business Property. OMB Number: 1545-0184. Form...

  6. 76 FR 9077 - Proposed Collection; Comment Request for Form 2553

    Science.gov (United States)

    2011-02-16

    ..., Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Form 2553, Election by a Small Business Corporation. DATES: Written comments should be received on or before... . SUPPLEMENTARY INFORMATION: Title: Election by a Small Business Corporation. OMB Number: 1545-0146. Form Number...

  7. 78 FR 39830 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-07-02

    ... Reduction Act of 1995, Public Law 104-13(44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments... separate transactions method of accounting (DASTM). DATES: Written comments should be received on or before... Dollar Approximate Separate Transactions Method of Accounting (DASTM). OMB Number: 1545-1051. Regulation...

  8. 77 FR 57196 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2012-09-17

    ... 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning limitations on corporate net operating loss carryforwards. DATES: Written comments should be received on or... Corporate Net Operating Loss Carryforwards. OMB Number: 1545-1260. Regulation Project Number: CO-62-89...

  9. 78 FR 8222 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-02-05

    ... Minimum Tax--Tax Benefit Rule. DATES: Written comments should be received on or before April 8, 2013 to be assured of consideration. ADDRESSES: Direct all written comments to Yvette Lawrence, Internal Revenue... Tax--Tax Benefit Rule. OMB Number: 1545-1093. Regulation Project Number: IA-56-87 and IA- 53-87 (TD...

  10. 77 FR 19032 - Certain Semiconductor Integrated Circuit Devices and Products Containing Same Notice of Receipt...

    Science.gov (United States)

    2012-03-29

    ...Notice is hereby given that the U.S. International Trade Commission has received a complaint entitled Certain Semiconductor Integrated Circuit Devices and Products Containing Same, DN 2888; the Commission is soliciting comments on any public interest issues raised by the complaint or complainant's filing under section 210.8(b) of the Commission's Rules of Practice and Procedure (19 CFR 210.8(b)).

  11. Statistical aspects of the 1980 solar flares. Part 3: Parametric comparison and final comments

    International Nuclear Information System (INIS)

    Wilson, R.M.

    1983-04-01

    The 1349 study flares are considered addressing relationships between pairs of specific study paremeters namely, H alpha rise time versus H alpha importance, X-ray class and H alpha decay time, H alpha decay time versus H alpha importance, and X-ray class, and H alpha importance versus X-ray class. Mean H alpha rise time and decay time versus X-ray class and H alpha importance will also be discussed, and some final comments regarding the study flares are given

  12. An application specific integrated circuit and data acquisition system for digital X-ray imaging

    Energy Technology Data Exchange (ETDEWEB)

    Beuville, E.; Cederstroem, B.; Danielsson, M.; Luo, L.; Nygren, D.; Oltman, E.; Vestlund, J. [Lawrence Berkeley National Lab., CA (United States)

    1998-04-01

    We have developed an application specific integrated circuit (ASIC) and data acquisition system for digital X-ray imaging. The chip consists of 16 parallel channels, each containing preamplifier, shaper, comparator and a 16 bit counter. We have demonstrated noiseless single-photon counting over a threshold of 7.2 keV using Silicon detectors and are presently capable of maximum counting rates of 2 MHz per channel. The ASIC is controlled by a personal computer through a commercial PCI card, which is also used for data acquisition. The content of the 16 bit counters are loaded into a shift register and transferred to the PC at any time at a rate of 20 MHz. The system is non-complicated, low cost and high performance and is optimised for digital X-ray imaging applications. (orig.). 11 refs.

  13. An application specific integrated circuit and data acquisition system for digital X-ray imaging

    International Nuclear Information System (INIS)

    Beuville, E.; Cederstroem, B.; Danielsson, M.; Luo, L.; Nygren, D.; Oltman, E.; Vestlund, J.

    1998-01-01

    We have developed an application specific integrated circuit (ASIC) and data acquisition system for digital X-ray imaging. The chip consists of 16 parallel channels, each containing preamplifier, shaper, comparator and a 16 bit counter. We have demonstrated noiseless single-photon counting over a threshold of 7.2 keV using Silicon detectors and are presently capable of maximum counting rates of 2 MHz per channel. The ASIC is controlled by a personal computer through a commercial PCI card, which is also used for data acquisition. The content of the 16 bit counters are loaded into a shift register and transferred to the PC at any time at a rate of 20 MHz. The system is non-complicated, low cost and high performance and is optimised for digital X-ray imaging applications. (orig.)

  14. Rule-based Information Integration

    NARCIS (Netherlands)

    de Keijzer, Ander; van Keulen, Maurice

    2005-01-01

    In this report, we show the process of information integration. We specifically discuss the language used for integration. We show that integration consists of two phases, the schema mapping phase and the data integration phase. We formally define transformation rules, conversion, evolution and

  15. 76 FR 9004 - Public Comment on Setting Achievement Levels in Writing

    Science.gov (United States)

    2011-02-16

    ... DEPARTMENT OF EDUCATION Public Comment on Setting Achievement Levels in Writing AGENCY: U.S... Achievement Levels in Writing. SUMMARY: The National Assessment Governing Board (Governing Board) is... for NAEP in writing. This notice provides opportunity for public comment and submitting...

  16. Comment on 'Energy in one-dimensional linear waves in a string'

    International Nuclear Information System (INIS)

    Butikov, Eugene I

    2011-01-01

    In this communication we comment on numerous erroneous statements in a recent letter to this journal by Burko (Eur. J. Phys. 2010 31 L71-7) concerning the energy transferred by transverse waves in a stretched string. (letters and comments)

  17. 78 FR 32691 - Proposed Collection; Comment Request; Certificate of Electrical Training

    Science.gov (United States)

    2013-05-31

    ... in the desired format, reporting burden (time and financial resources) is minimized, collection... with an opportunity to comment on proposed and continuing collections of information in accordance with..., 2013. ADDRESSES: Comments concerning the information collection requirements of this notice must be...

  18. 78 FR 24312 - Proposed Collection; Comment Request for Form 5308

    Science.gov (United States)

    2013-04-24

    ..., Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Form 5308, Request for Change in Plan/Trust Year. DATES: Written comments should be received on or before... . SUPPLEMENTARY INFORMATION: Title: Request for Change in Plan/Trust Year. OMB Number: 1545-0201. Form Number...

  19. 78 FR 70101 - Proposed Collection; Comment Request for Form 3800

    Science.gov (United States)

    2013-11-22

    ..., Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Form 3800, General Business Credit. DATES: Written comments should be received on or before January 21, 2014... Business Credit. OMB Number: 1545-0895. Form Number: Form 3800. Abstract: Internal Revenue Code section 38...

  20. 76 FR 55741 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2011-09-08

    ... 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Qualified Separate Lines of Business. DATES: Written comments should be received on or before November 7...: Title: Qualified Separate Lines of Business. OMB Number: 1545-1221. Regulation Project Number: EE-147-87...