WorldWideScience

Sample records for integrated primer designing

  1. Primer3_masker: integrating masking of template sequence with primer design software.

    Science.gov (United States)

    Kõressaar, Triinu; Lepamets, Maarja; Kaplinski, Lauris; Raime, Kairi; Andreson, Reidar; Remm, Maido

    2018-06-01

    Designing PCR primers for amplifying regions of eukaryotic genomes is a complicated task because the genomes contain a large number of repeat sequences and other regions unsuitable for amplification by PCR. We have developed a novel k-mer based masking method that uses a statistical model to detect and mask failure-prone regions on the DNA template prior to primer design. We implemented the software as a standalone software primer3_masker and integrated it into the primer design program Primer3. The standalone version of primer3_masker is implemented in C. The source code is freely available at https://github.com/bioinfo-ut/primer3_masker/ (standalone version for Linux and macOS) and at https://github.com/primer3-org/primer3/ (integrated version). Primer3 web application that allows masking sequences of 196 animal and plant genomes is available at http://primer3.ut.ee/. maido.remm@ut.ee. Supplementary data are available at Bioinformatics online.

  2. Integrating PCR Theory and Bioinformatics into a Research-oriented Primer Design Exercise

    OpenAIRE

    Robertson, Amber L.; Phillips, Allison R.

    2008-01-01

    Polymerase chain reaction (PCR) is a conceptually difficult technique that embodies many fundamental biological processes. Traditionally, students have struggled to analyze PCR results due to an incomplete understanding of the biological concepts (theory) of DNA replication and strand complementarity. Here we describe the design of a novel research-oriented exercise that prepares students to design DNA primers for PCR. Our exercise design includes broad and specific learning goals and assessm...

  3. MethPrimer: designing primers for methylation PCRs.

    Science.gov (United States)

    Li, Long-Cheng; Dahiya, Rajvir

    2002-11-01

    DNA methylation is an epigenetic mechanism of gene regulation. Bisulfite- conversion-based PCR methods, such as bisulfite sequencing PCR (BSP) and methylation specific PCR (MSP), remain the most commonly used techniques for methylation mapping. Existing primer design programs developed for standard PCR cannot handle primer design for bisulfite-conversion-based PCRs due to changes in DNA sequence context caused by bisulfite treatment and many special constraints both on the primers and the region to be amplified for such experiments. Therefore, the present study was designed to develop a program for such applications. MethPrimer, based on Primer 3, is a program for designing PCR primers for methylation mapping. It first takes a DNA sequence as its input and searches the sequence for potential CpG islands. Primers are then picked around the predicted CpG islands or around regions specified by users. MethPrimer can design primers for BSP and MSP. Results of primer selection are delivered through a web browser in text and in graphic view.

  4. Bioinformatic tools for PCR Primer design

    African Journals Online (AJOL)

    ES

    reaction (PCR), oligo hybridization and DNA sequencing. Proper primer design is actually one of the most important factors/steps in successful DNA sequencing. Various bioinformatics programs are available for selection of primer pairs from a template sequence. The plethora programs for PCR primer design reflects the.

  5. UniPrimer: A Web-Based Primer Design Tool for Comparative Analyses of Primate Genomes

    Directory of Open Access Journals (Sweden)

    Nomin Batnyam

    2012-01-01

    Full Text Available Whole genome sequences of various primates have been released due to advanced DNA-sequencing technology. A combination of computational data mining and the polymerase chain reaction (PCR assay to validate the data is an excellent method for conducting comparative genomics. Thus, designing primers for PCR is an essential procedure for a comparative analysis of primate genomes. Here, we developed and introduced UniPrimer for use in those studies. UniPrimer is a web-based tool that designs PCR- and DNA-sequencing primers. It compares the sequences from six different primates (human, chimpanzee, gorilla, orangutan, gibbon, and rhesus macaque and designs primers on the conserved region across species. UniPrimer is linked to RepeatMasker, Primer3Plus, and OligoCalc softwares to produce primers with high accuracy and UCSC In-Silico PCR to confirm whether the designed primers work. To test the performance of UniPrimer, we designed primers on sample sequences using UniPrimer and manually designed primers for the same sequences. The comparison of the two processes showed that UniPrimer was more effective than manual work in terms of saving time and reducing errors.

  6. Scrimer: designing primers from transcriptome data

    Czech Academy of Sciences Publication Activity Database

    Mořkovský, Libor; Pačes, Jan; Rídl, Jakub; Reifová, R.

    2015-01-01

    Roč. 15, č. 6 (2015), s. 1415-1420 ISSN 1755-098X R&D Projects: GA MŠk EE2.3.20.0303 Institutional support: RVO:68081766 ; RVO:68378050 Keywords : next-generation sequencing * primer design * SNaPshot * SNP genotyping * transcriptome Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 5.298, year: 2015

  7. PHUSER (Primer Help for USER): a novel tool for USER fusion primer design

    DEFF Research Database (Denmark)

    Olsen, Lars Rønn; Hansen, Niels Bjørn; Bonde, Mads

    2011-01-01

    containing a customizable USER cassette. Designing primers using PHUSER ensures that the primers have similar annealing temperature (Tm), which is essential for efficient PCR. PHUSER also avoids identical overhangs, thereby ensuring correct order of assembly of DNA fragments. All possible primers...

  8. CRISPR Primer Designer: Design primers for knockout and chromosome imaging CRISPR-Cas system.

    Science.gov (United States)

    Yan, Meng; Zhou, Shi-Rong; Xue, Hong-Wei

    2015-07-01

    The clustered regularly interspaced short palindromic repeats (CRISPR)-associated system enables biologists to edit genomes precisely and provides a powerful tool for perturbing endogenous gene regulation, modulation of epigenetic markers, and genome architecture. However, there are concerns about the specificity of the system, especially the usages of knocking out a gene. Previous designing tools either were mostly built-in websites or ran as command-line programs, and none of them ran locally and acquired a user-friendly interface. In addition, with the development of CRISPR-derived systems, such as chromosome imaging, there were still no tools helping users to generate specific end-user spacers. We herein present CRISPR Primer Designer for researchers to design primers for CRISPR applications. The program has a user-friendly interface, can analyze the BLAST results by using multiple parameters, score for each candidate spacer, and generate the primers when using a certain plasmid. In addition, CRISPR Primer Designer runs locally and can be used to search spacer clusters, and exports primers for the CRISPR-Cas system-based chromosome imaging system. © 2014 Institute of Botany, Chinese Academy of Sciences.

  9. VizPrimer: a web server for visualized PCR primer design based on known gene structure.

    Science.gov (United States)

    Zhou, Yang; Qu, Wubin; Lu, Yiming; Zhang, Yanchun; Wang, Xiaolei; Zhao, Dongsheng; Yang, Yi; Zhang, Chenggang

    2011-12-15

    The visualization of gene structure plays an important role in polymerase chain reaction (PCR) primer design, especially for eukaryotic genes with a number of splice variants that users need to distinguish between via PCR. Here, we describe a visualized web server for primer design named VizPrimer. It utilizes the new information technology (IT) tools, HTML5 to display gene structure and JavaScript to interact with the users. In VizPrimer, the users can focus their attention on the gene structure and primer design strategy, without wasting time calculating the exon positions of splice variants or manually configuring complicated parameters. In addition, VizPrimer is also suitable for the design of PCR primers for amplifying open reading frames and detecting single nucleotide polymorphisms (SNPs). VizPrimer is freely available at http://biocompute.bmi.ac.cn/CZlab/VizPrimer/. The web server supported browsers: Chrome (≥5.0), Firefox (≥3.0), Safari (≥4.0) and Opera (≥10.0). zhangcg@bmi.ac.cn; yangyi528@vip.sina.com.

  10. Bioinformatic tools and guideline for PCR primer design | Abd ...

    African Journals Online (AJOL)

    Bioinformatics has become an essential tool not only for basic research but also for applied research in biotechnology and biomedical sciences. Optimal primer sequence and appropriate primer concentration are essential for maximal specificity and efficiency of PCR. A poorly designed primer can result in little or no ...

  11. MPprimer: a program for reliable multiplex PCR primer design

    Directory of Open Access Journals (Sweden)

    Wang Xiaolei

    2010-03-01

    Full Text Available Abstract Background Multiplex PCR, defined as the simultaneous amplification of multiple regions of a DNA template or multiple DNA templates using more than one primer set (comprising a forward primer and a reverse primer in one tube, has been widely used in diagnostic applications of clinical and environmental microbiology studies. However, primer design for multiplex PCR is still a challenging problem and several factors need to be considered. These problems include mis-priming due to nonspecific binding to non-target DNA templates, primer dimerization, and the inability to separate and purify DNA amplicons with similar electrophoretic mobility. Results A program named MPprimer was developed to help users for reliable multiplex PCR primer design. It employs the widely used primer design program Primer3 and the primer specificity evaluation program MFEprimer to design and evaluate the candidate primers based on genomic or transcript DNA database, followed by careful examination to avoid primer dimerization. The graph-expanding algorithm derived from the greedy algorithm was used to determine the optimal primer set combinations (PSCs for multiplex PCR assay. In addition, MPprimer provides a virtual electrophotogram to help users choose the best PSC. The experimental validation from 2× to 5× plex PCR demonstrates the reliability of MPprimer. As another example, MPprimer is able to design the multiplex PCR primers for DMD (dystrophin gene which caused Duchenne Muscular Dystrophy, which has 79 exons, for 20×, 20×, 20×, 14×, and 5× plex PCR reactions in five tubes to detect underlying exon deletions. Conclusions MPprimer is a valuable tool for designing specific, non-dimerizing primer set combinations with constrained amplicons size for multiplex PCR assays.

  12. Designing for transportation management and operations : a primer.

    Science.gov (United States)

    2013-02-01

    This primer is focused on the collaborative and systematic consideration of management and operations during transportation : project design and development. This is termed designing for operations. Effectively designing for operations involves...

  13. Tools for Ultraspecific Probe/Primer Design

    National Research Council Canada - National Science Library

    Fofanov, Yurly

    2006-01-01

    .... Our approach will deliver DNA probes and PCR primers that have an unprecedentedly low probability of false positives or confusion by environmental background, and which resist evasion by threat agent engineering...

  14. Bioinformatic tools for PCR Primer design

    African Journals Online (AJOL)

    ES

    Bioinformatics is an emerging scientific discipline that uses information ... complex biological questions. ... and computer programs for various purposes of primer ..... polymerase chain reaction: Human Immunodeficiency Virus 1 model studies.

  15. MSP-HTPrimer: a high-throughput primer design tool to improve assay design for DNA methylation analysis in epigenetics.

    Science.gov (United States)

    Pandey, Ram Vinay; Pulverer, Walter; Kallmeyer, Rainer; Beikircher, Gabriel; Pabinger, Stephan; Kriegner, Albert; Weinhäusel, Andreas

    2016-01-01

    Bisulfite (BS) conversion-based and methylation-sensitive restriction enzyme (MSRE)-based PCR methods have been the most commonly used techniques for locus-specific DNA methylation analysis. However, both methods have advantages and limitations. Thus, an integrated approach would be extremely useful to quantify the DNA methylation status successfully with great sensitivity and specificity. Designing specific and optimized primers for target regions is the most critical and challenging step in obtaining the adequate DNA methylation results using PCR-based methods. Currently, no integrated, optimized, and high-throughput methylation-specific primer design software methods are available for both BS- and MSRE-based methods. Therefore an integrated, powerful, and easy-to-use methylation-specific primer design pipeline with great accuracy and success rate will be very useful. We have developed a new web-based pipeline, called MSP-HTPrimer, to design primers pairs for MSP, BSP, pyrosequencing, COBRA, and MSRE assays on both genomic strands. First, our pipeline converts all target sequences into bisulfite-treated templates for both forward and reverse strand and designs all possible primer pairs, followed by filtering for single nucleotide polymorphisms (SNPs) and known repeat regions. Next, each primer pairs are annotated with the upstream and downstream RefSeq genes, CpG island, and cut sites (for COBRA and MSRE). Finally, MSP-HTPrimer selects specific primers from both strands based on custom and user-defined hierarchical selection criteria. MSP-HTPrimer produces a primer pair summary output table in TXT and HTML format for display and UCSC custom tracks for resulting primer pairs in GTF format. MSP-HTPrimer is an integrated, web-based, and high-throughput pipeline and has no limitation on the number and size of target sequences and designs MSP, BSP, pyrosequencing, COBRA, and MSRE assays. It is the only pipeline, which automatically designs primers on both genomic

  16. Primer on gas integrated resource planning

    Energy Technology Data Exchange (ETDEWEB)

    Goldman, C.; Comnes, G.A.; Busch, J.; Wiel, S. [Lawrence Berkeley Lab., CA (United States)

    1993-12-01

    This report discusses the following topics: gas resource planning: need for IRP; gas integrated resource planning: methods and models; supply and capacity planning for gas utilities; methods for estimating gas avoided costs; economic analysis of gas utility DSM programs: benefit-cost tests; gas DSM technologies and programs; end-use fuel substitution; and financial aspects of gas demand-side management programs.

  17. A Primer on Autonomous Aerial Vehicle Design.

    Science.gov (United States)

    Coppejans, Hugo H G; Myburgh, Herman C

    2015-12-02

    There is a large amount of research currently being done on autonomous micro-aerial vehicles (MAV), such as quadrotor helicopters or quadcopters. The ability to create a working autonomous MAV depends mainly on integrating a simultaneous localization and mapping (SLAM) solution with the rest of the system. This paper provides an introduction for creating an autonomous MAV for enclosed environments, aimed at students and professionals alike. The standard autonomous system and MAV automation are discussed, while we focus on the core concepts of SLAM systems and trajectory planning algorithms. The advantages and disadvantages of using remote processing are evaluated, and recommendations are made regarding the viability of on-board processing. Recommendations are made regarding best practices to serve as a guideline for aspirant MAV designers.

  18. A Primer on Autonomous Aerial Vehicle Design

    Directory of Open Access Journals (Sweden)

    Hugo H. G. Coppejans

    2015-12-01

    Full Text Available There is a large amount of research currently being done on autonomous micro-aerial vehicles (MAV, such as quadrotor helicopters or quadcopters. The ability to create a working autonomous MAV depends mainly on integrating a simultaneous localization and mapping (SLAM solution with the rest of the system. This paper provides an introduction for creating an autonomous MAV for enclosed environments, aimed at students and professionals alike. The standard autonomous system and MAV automation are discussed, while we focus on the core concepts of SLAM systems and trajectory planning algorithms. The advantages and disadvantages of using remote processing are evaluated, and recommendations are made regarding the viability of on-board processing. Recommendations are made regarding best practices to serve as a guideline for aspirant MAV designers.

  19. Integrated Design

    DEFF Research Database (Denmark)

    Lenau, Torben Anker

    1999-01-01

    A homepage on the internet with course material, lecture plan, student exercises, etc. Continuesly updated during the course Integrated Design (80402, 80403)......A homepage on the internet with course material, lecture plan, student exercises, etc. Continuesly updated during the course Integrated Design (80402, 80403)...

  20. UniPrime2: a web service providing easier Universal Primer design.

    Science.gov (United States)

    Boutros, Robin; Stokes, Nicola; Bekaert, Michaël; Teeling, Emma C

    2009-07-01

    The UniPrime2 web server is a publicly available online resource which automatically designs large sets of universal primers when given a gene reference ID or Fasta sequence input by a user. UniPrime2 works by automatically retrieving and aligning homologous sequences from GenBank, identifying regions of conservation within the alignment, and generating suitable primers that can be used to amplify variable genomic regions. In essence, UniPrime2 is a suite of publicly available software packages (Blastn, T-Coffee, GramAlign, Primer3), which reduces the laborious process of primer design, by integrating these programs into a single software pipeline. Hence, UniPrime2 differs from previous primer design web services in that all steps are automated, linked, saved and phylogenetically delimited, only requiring a single user-defined gene reference ID or input sequence. We provide an overview of the web service and wet-laboratory validation of the primers generated. The system is freely accessible at: http://uniprime.batlab.eu. UniPrime2 is licenced under a Creative Commons Attribution Noncommercial-Share Alike 3.0 Licence.

  1. Integrated Design

    DEFF Research Database (Denmark)

    Jørgensen, Michael; Nielsen, M. W.; Strømann-Andersen, Jakob Bjørn

    2011-01-01

    and describe the decision process. Specific attention is given to how the engineering input was presented and how it was able to facilitate the design development. Site and context, building shape, organization of functions and HVAC-systems were all included to obtain a complete picture of the building......, low-energy consumption, and high-quality indoor environment. We use this case study to investigate how technical knowledge about building performance can be integrated into the conceptual design stage. We have selected certain points during the design process that represented design challenges...

  2. MCMC-ODPR: Primer design optimization using Markov Chain Monte Carlo sampling

    Directory of Open Access Journals (Sweden)

    Kitchen James L

    2012-11-01

    Full Text Available Abstract Background Next generation sequencing technologies often require numerous primer designs that require good target coverage that can be financially costly. We aimed to develop a system that would implement primer reuse to design degenerate primers that could be designed around SNPs, thus find the fewest necessary primers and the lowest cost whilst maintaining an acceptable coverage and provide a cost effective solution. We have implemented Metropolis-Hastings Markov Chain Monte Carlo for optimizing primer reuse. We call it the Markov Chain Monte Carlo Optimized Degenerate Primer Reuse (MCMC-ODPR algorithm. Results After repeating the program 1020 times to assess the variance, an average of 17.14% fewer primers were found to be necessary using MCMC-ODPR for an equivalent coverage without implementing primer reuse. The algorithm was able to reuse primers up to five times. We compared MCMC-ODPR with single sequence primer design programs Primer3 and Primer-BLAST and achieved a lower primer cost per amplicon base covered of 0.21 and 0.19 and 0.18 primer nucleotides on three separate gene sequences, respectively. With multiple sequences, MCMC-ODPR achieved a lower cost per base covered of 0.19 than programs BatchPrimer3 and PAMPS, which achieved 0.25 and 0.64 primer nucleotides, respectively. Conclusions MCMC-ODPR is a useful tool for designing primers at various melting temperatures at good target coverage. By combining degeneracy with optimal primer reuse the user may increase coverage of sequences amplified by the designed primers at significantly lower costs. Our analyses showed that overall MCMC-ODPR outperformed the other primer-design programs in our study in terms of cost per covered base.

  3. MCMC-ODPR: primer design optimization using Markov Chain Monte Carlo sampling.

    Science.gov (United States)

    Kitchen, James L; Moore, Jonathan D; Palmer, Sarah A; Allaby, Robin G

    2012-11-05

    Next generation sequencing technologies often require numerous primer designs that require good target coverage that can be financially costly. We aimed to develop a system that would implement primer reuse to design degenerate primers that could be designed around SNPs, thus find the fewest necessary primers and the lowest cost whilst maintaining an acceptable coverage and provide a cost effective solution. We have implemented Metropolis-Hastings Markov Chain Monte Carlo for optimizing primer reuse. We call it the Markov Chain Monte Carlo Optimized Degenerate Primer Reuse (MCMC-ODPR) algorithm. After repeating the program 1020 times to assess the variance, an average of 17.14% fewer primers were found to be necessary using MCMC-ODPR for an equivalent coverage without implementing primer reuse. The algorithm was able to reuse primers up to five times. We compared MCMC-ODPR with single sequence primer design programs Primer3 and Primer-BLAST and achieved a lower primer cost per amplicon base covered of 0.21 and 0.19 and 0.18 primer nucleotides on three separate gene sequences, respectively. With multiple sequences, MCMC-ODPR achieved a lower cost per base covered of 0.19 than programs BatchPrimer3 and PAMPS, which achieved 0.25 and 0.64 primer nucleotides, respectively. MCMC-ODPR is a useful tool for designing primers at various melting temperatures at good target coverage. By combining degeneracy with optimal primer reuse the user may increase coverage of sequences amplified by the designed primers at significantly lower costs. Our analyses showed that overall MCMC-ODPR outperformed the other primer-design programs in our study in terms of cost per covered base.

  4. Hydrologic design methodologies for small-scale hydro at ungauged sites. Phase 2A, British Columbia. Primer for Integrated Method for Power Analysis (IMP)

    Energy Technology Data Exchange (ETDEWEB)

    1986-01-01

    This report provides a user's manual for the Integrated Method for Power Analysis (IMP) series of programs, developed to aid in evaluating small-scale hydroelectric power sites in British Columbia. The primary objective of IMP is to address the problem posed by hydroelectric development at sites completely lacking in streamflow records. The province's mountainous terrain, with numerous microclimates, precluded methods of regional analysis based on regression or comparisons with gauged streams; instead, a conceptual model of physical processes on the land and in the atmosphere was used as a basis for developing IMP. The IMP package consists of five basic components: an atmospheric model of annual precipitation and 1-in-10-year 24-h maximum rainfall; a watershed model that will generate a daily series of streamflow data; a flood frequency analysis system that uses site-specific topographical information and information from the atmospheric model to generate the flood frequency curve; a hydroelectric power simulation program which determines the daily energy output for a run-of-river or reservoir storage site; and a graphics analysis package which provides direct visualization of atmospheric and streamflow data, and the results of watershed and power simulation modelling. Within each component of the program, the program requirements and capabilities are discussed. A series of sample screens are shown, illustrating the use of the IMP package for a particular simulation. 18 figs., 2 tabs.

  5. FullSSR: Microsatellite Finder and Primer Designer

    Directory of Open Access Journals (Sweden)

    Sebastián Metz

    2016-01-01

    Full Text Available Microsatellites are genomic sequences comprised of tandem repeats of short nucleotide motifs widely used as molecular markers in population genetics. FullSSR is a new bioinformatic tool for microsatellite (SSR loci detection and primer design using genomic data from NGS assay. The software was tested with 2000 sequences of Oryza sativa shotgun sequencing project from the National Center of Biotechnology Information Trace Archive and with partial genome sequencing with ROCHE 454® from Caiman latirostris, Salvator merianae, Aegla platensis, and Zilchiopsis collastinensis. FullSSR performance was compared against other similar SSR search programs. The results of the use of this kind of approach depend on the parameters set by the user. In addition, results can be affected by the analyzed sequences because of differences among the genomes. FullSSR simplifies the detection of SSRs and primer design on a big data set. The command line interface of FullSSR was intended to be used as part of genomic analysis tools pipeline; however, it can be used as a stand-alone program because the results are easily interpreted for a nonexpert user.

  6. Conserved PCR primer set designing for closely-related species to complete mitochondrial genome sequencing using a sliding window-based PSO algorithm.

    Directory of Open Access Journals (Sweden)

    Cheng-Hong Yang

    Full Text Available BACKGROUND: Complete mitochondrial (mt genome sequencing is becoming increasingly common for phylogenetic reconstruction and as a model for genome evolution. For long template sequencing, i.e., like the entire mtDNA, it is essential to design primers for Polymerase Chain Reaction (PCR amplicons which are partly overlapping each other. The presented chromosome walking strategy provides the overlapping design to solve the problem for unreliable sequencing data at the 5' end and provides the effective sequencing. However, current algorithms and tools are mostly focused on the primer design for a local region in the genomic sequence. Accordingly, it is still challenging to provide the primer sets for the entire mtDNA. METHODOLOGY/PRINCIPAL FINDINGS: The purpose of this study is to develop an integrated primer design algorithm for entire mt genome in general, and for the common primer sets for closely-related species in particular. We introduce ClustalW to generate the multiple sequence alignment needed to find the conserved sequences in closely-related species. These conserved sequences are suitable for designing the common primers for the entire mtDNA. Using a heuristic algorithm particle swarm optimization (PSO, all the designed primers were computationally validated to fit the common primer design constraints, such as the melting temperature, primer length and GC content, PCR product length, secondary structure, specificity, and terminal limitation. The overlap requirement for PCR amplicons in the entire mtDNA is satisfied by defining the overlapping region with the sliding window technology. Finally, primer sets were designed within the overlapping region. The primer sets for the entire mtDNA sequences were successfully demonstrated in the example of two closely-related fish species. The pseudo code for the primer design algorithm is provided. CONCLUSIONS/SIGNIFICANCE: In conclusion, it can be said that our proposed sliding window-based PSO

  7. Integrated STEM: A New Primer for Teaching Technology Education

    Science.gov (United States)

    Asunda, Paul A.; Mativo, John

    2017-01-01

    Part One of this article ("Technology and Engineering Teacher," 75(4), December/January, 2016) presented a process that science, math, engineering, and technology teachers could use to collaborate and design integrated STEM courses. A conceptual framework was discussed that could provide a premise that educators interested in delivery of…

  8. Building a Foundation for Effective Technology Transfer through Integration with the Research Process : a Primer.

    Science.gov (United States)

    2016-03-01

    This primer aims to increase the effectiveness of T2 activity in transportation by describing how T2 practices can be successfully integrated into : the research process to capture the potential real-world benefits of our communitys research inves...

  9. Primer design for a prokaryotic differential display RT-PCR.

    Science.gov (United States)

    Fislage, R; Berceanu, M; Humboldt, Y; Wendt, M; Oberender, H

    1997-05-01

    We have developed a primer set for a prokaryotic differential display of mRNA in the Enterobacteriaceae group. Each combination of ten 10mer and ten 11mer primers generates up to 85 bands from total Escherichia coli RNA, thus covering expressed sequences of a complete bacterial genome. Due to the lack of polyadenylation in prokaryotic RNA the type T11VN anchored oligonucleotides for the reverse transcriptase reaction had to be replaced with respect to the original method described by Liang and Pardee [ Science , 257, 967-971 (1992)]. Therefore, the sequences of both the 10mer and the new 11mer oligonucleotides were determined by a statistical evaluation of species-specific coding regions extracted from the EMBL database. The 11mer primers used for reverse transcription were selected for localization in the 3'-region of the bacterial RNA. The 10mer primers preferentially bind to the 5'-end of the RNA. None of the primers show homology to rRNA or other abundant small RNA species. Randomly sampled cDNA bands were checked for their bacterial origin either by re-amplification, cloning and sequencing or by re-amplification and direct sequencing with 10mer and 11mer primers after asymmetric PCR.

  10. Design of a Percussion and Electric Primer Gun Firing Power Supply

    Science.gov (United States)

    2014-07-01

    solenoid failure. As new instrumentation techniques such as high-speed video and laser interferometry have been introduced into our gun testing...to drive a solenoid into a percussion primer or ignite the M52A3B1 electric primer. To reduce power requirements, it uses charged capacitor banks to...drive the solenoid or ignite the primer. This report details the design and construction of the power supplies. 15. SUBJECT TERMS power supply

  11. Automated degenerate PCR primer design for high-throughput sequencing improves efficiency of viral sequencing

    Directory of Open Access Journals (Sweden)

    Li Kelvin

    2012-11-01

    Full Text Available Abstract Background In a high-throughput environment, to PCR amplify and sequence a large set of viral isolates from populations that are potentially heterogeneous and continuously evolving, the use of degenerate PCR primers is an important strategy. Degenerate primers allow for the PCR amplification of a wider range of viral isolates with only one set of pre-mixed primers, thus increasing amplification success rates and minimizing the necessity for genome finishing activities. To successfully select a large set of degenerate PCR primers necessary to tile across an entire viral genome and maximize their success, this process is best performed computationally. Results We have developed a fully automated degenerate PCR primer design system that plays a key role in the J. Craig Venter Institute’s (JCVI high-throughput viral sequencing pipeline. A consensus viral genome, or a set of consensus segment sequences in the case of a segmented virus, is specified using IUPAC ambiguity codes in the consensus template sequence to represent the allelic diversity of the target population. PCR primer pairs are then selected computationally to produce a minimal amplicon set capable of tiling across the full length of the specified target region. As part of the tiling process, primer pairs are computationally screened to meet the criteria for successful PCR with one of two described amplification protocols. The actual sequencing success rates for designed primers for measles virus, mumps virus, human parainfluenza virus 1 and 3, human respiratory syncytial virus A and B and human metapneumovirus are described, where >90% of designed primer pairs were able to consistently successfully amplify >75% of the isolates. Conclusions Augmenting our previously developed and published JCVI Primer Design Pipeline, we achieved similarly high sequencing success rates with only minor software modifications. The recommended methodology for the construction of the consensus

  12. Specific primer design of mitochondrial 12S rRNA for species identification in raw meats

    Science.gov (United States)

    Cahyadi, M.; Puruhita; Barido, F. H.; Hertanto, B. S.

    2018-01-01

    Polymerase chain reaction (PCR) is a molecular technique that widely used in agriculture area including species identification in animal-based products for halalness and food safety reasons. Amplification of DNA using PCR needs a primer pair (forward and reverse primers) to isolate specific DNA fragment in the genome. This objective of this study was to design specific primer from mitochondrial 12S rRNA region for species identification in raw beef, pork and chicken meat. Three published sequences, HQ184045, JN601075, and KT626857, were downloaded from National Center for Biotechnology Information (NCBI) website. Furthermore, those reference sequences were used to design specific primer for bovine, pig, and chicken species using primer3 v.0.4.0. A total of 15 primer pairs were picked up from primer3 software. Of these, an universal forward primer and three reverse primers which are specific for bovine, pig, and chicken species were selected to be optimized using multiplex-PCR technique. The selected primers were namely UNIF (5’-ACC GCG GTC ATA CGA TTA AC-3’), SPR (5’-AGT GCG TCG GCT ATT GTA GG-3’), BBR (5’-GAA TTG GCA AGG GTT GGT AA-3’), and AR (5’-CGG TAT GTA CGT GCC TCA GA-3’). In addition, the PCR products were visualized using 2% agarose gels under the UV light and sequenced to be aligned with reference sequences using Clustal Omega. The result showed that those primers were specifically amplified mitochondrial 12S rRNA regions from bovine, pig, and chicken using PCR. It was indicated by the existence of 155, 357, and 611 bp of DNA bands for bovine, pig, and chicken species, respectively. Moreover, sequence analysis revealed that our sequences were identically similar with reference sequences. It can be concluded that mitochondrial 12S rRNA may be used as a genetic marker for species identification in meat products.

  13. A tool for design of primers for microRNA-specific quantitative RT-qPCR. BMC Bioinformatics

    DEFF Research Database (Denmark)

    Busk, Peter Kamp

    2014-01-01

    of formation of secondary structures and primer dimers. Testing of the primers showed that 76 out of 79 primers (96%) worked for quantification of microRNAs by miR-specific RT-qPCR of mammalian RNA samples. This success rate corresponds to the success rate of manual primer design. Furthermore, primers designed......Background MicroRNAs are small but biologically important RNA molecules. Although different methods can be used for quantification of microRNAs, quantitative PCR is regarded as the reference that is used to validate other methods. Several commercial qPCR assays are available but they often come...... at a high price and the sequences of the primers are not disclosed. An alternative to commercial assays is to manually design primers but this work is tedious and, hence, not practical for the design of primers for a larger number of targets. Results I have developed the software miRprimer for automatic...

  14. PRIMEGENSw3: a web-based tool for high-throughput primer and probe design.

    Science.gov (United States)

    Kushwaha, Garima; Srivastava, Gyan Prakash; Xu, Dong

    2015-01-01

    Highly specific and efficient primer and probe design has been a major hurdle in many high-throughput techniques. Successful implementation of any PCR or probe hybridization technique depends on the quality of primers and probes used in terms of their specificity and cross-hybridization. Here we describe PRIMEGENSw3, a set of web-based utilities for high-throughput primer and probe design. These utilities allow users to select genomic regions and to design primer/probe for selected regions in an interactive, user-friendly, and automatic fashion. The system runs the PRIMEGENS algorithm in the back-end on the high-performance server with the stored genomic database or user-provided custom database for cross-hybridization check. Cross-hybridization is checked not only using BLAST but also by checking mismatch positions and energy calculation of potential hybridization hits. The results can be visualized online and also can be downloaded. The average success rate of primer design using PRIMEGENSw3 is ~90 %. The web server also supports primer design for methylated sequences, which is used in epigenetic studies. Stand-alone version of the software is also available for download at the website.

  15. [Design of primers to DNA of lactic acid bacteria].

    Science.gov (United States)

    Lashchevskiĭ, V V; Kovalenko, N K

    2003-01-01

    Primers LP1-LP2 to the gene 16S rRNA have been developed, which permit to differentiate lactic acid bacteria: Lactobacillus plantarum, L. delbrueckii subsp. bulgaricus and Streptococcus salivarius subsp. thermophilus. The strain-specific and species-specific differentiations are possible under different annealing temperature. Additional fragments, which are synthesized outside the framework of gene 16S rRNA reading, provide for the strain-specific type of differentiation, and the fragment F864 read in the gene 16S rRNA permits identifying L. plantarum.

  16. Real-time PCR (qPCR) primer design using free online software.

    Science.gov (United States)

    Thornton, Brenda; Basu, Chhandak

    2011-01-01

    Real-time PCR (quantitative PCR or qPCR) has become the preferred method for validating results obtained from assays which measure gene expression profiles. The process uses reverse transcription polymerase chain reaction (RT-PCR), coupled with fluorescent chemistry, to measure variations in transcriptome levels between samples. The four most commonly used fluorescent chemistries are SYBR® Green dyes and TaqMan®, Molecular Beacon or Scorpion probes. SYBR® Green is very simple to use and cost efficient. As SYBR® Green dye binds to any double-stranded DNA product, its success depends greatly on proper primer design. Many types of online primer design software are available, which can be used free of charge to design desirable SYBR® Green-based qPCR primers. This laboratory exercise is intended for those who have a fundamental background in PCR. It addresses the basic fluorescent chemistries of real-time PCR, the basic rules and pitfalls of primer design, and provides a step-by-step protocol for designing SYBR® Green-based primers with free, online software. Copyright © 2010 Wiley Periodicals, Inc.

  17. GST-PRIME: an algorithm for genome-wide primer design.

    Science.gov (United States)

    Leister, Dario; Varotto, Claudio

    2007-01-01

    The profiling of mRNA expression based on DNA arrays has become a powerful tool to study genome-wide transcription of genes in a number of organisms. GST-PRIME is a software package created to facilitate large-scale primer design for the amplification of probes to be immobilized on arrays for transcriptome analyses, even though it can be also applied in low-throughput approaches. GST-PRIME allows highly efficient, direct amplification of gene-sequence tags (GSTs) from genomic DNA (gDNA), starting from annotated genome or transcript sequences. GST-PRIME provides a customer-friendly platform for automatic primer design, and despite the relative simplicity of the algorithm, experimental tests in the model plant species Arabidopsis thaliana confirmed the reliability of the software. This chapter describes the algorithm used for primer design, its input and output files, and the installation of the standalone package and its use.

  18. Designing universal primers for the isolation of DNA sequences encoding Proanthocyanidins biosynthetic enzymes in Crataegus aronia

    Directory of Open Access Journals (Sweden)

    Zuiter Afnan

    2012-08-01

    Full Text Available Abstract Background Hawthorn is the common name of all plant species in the genus Crataegus, which belongs to the Rosaceae family. Crataegus are considered useful medicinal plants because of their high content of proanthocyanidins (PAs and other related compounds. To improve PAs production in Crataegus tissues, the sequences of genes encoding PAs biosynthetic enzymes are required. Findings Different bioinformatics tools, including BLAST, multiple sequence alignment and alignment PCR analysis were used to design primers suitable for the amplification of DNA fragments from 10 candidate genes encoding enzymes involved in PAs biosynthesis in C. aronia. DNA sequencing results proved the utility of the designed primers. The primers were used successfully to amplify DNA fragments of different PAs biosynthesis genes in different Rosaceae plants. Conclusion To the best of our knowledge, this is the first use of the alignment PCR approach to isolate DNA sequences encoding PAs biosynthetic enzymes in Rosaceae plants.

  19. MOS integrated circuit design

    CERN Document Server

    Wolfendale, E

    2013-01-01

    MOS Integral Circuit Design aims to help in the design of integrated circuits, especially large-scale ones, using MOS Technology through teaching of techniques, practical applications, and examples. The book covers topics such as design equation and process parameters; MOS static and dynamic circuits; logic design techniques, system partitioning, and layout techniques. Also featured are computer aids such as logic simulation and mask layout, as well as examples on simple MOS design. The text is recommended for electrical engineers who would like to know how to use MOS for integral circuit desi

  20. Implementing Clinical Research Using Factorial Designs: A Primer.

    Science.gov (United States)

    Baker, Timothy B; Smith, Stevens S; Bolt, Daniel M; Loh, Wei-Yin; Mermelstein, Robin; Fiore, Michael C; Piper, Megan E; Collins, Linda M

    2017-07-01

    Factorial experiments have rarely been used in the development or evaluation of clinical interventions. However, factorial designs offer advantages over randomized controlled trial designs, the latter being much more frequently used in such research. Factorial designs are highly efficient (permitting evaluation of multiple intervention components with good statistical power) and present the opportunity to detect interactions amongst intervention components. Such advantages have led methodologists to advocate for the greater use of factorial designs in research on clinical interventions (Collins, Dziak, & Li, 2009). However, researchers considering the use of such designs in clinical research face a series of choices that have consequential implications for the interpretability and value of the experimental results. These choices include: whether to use a factorial design, selection of the number and type of factors to include, how to address the compatibility of the different factors included, whether and how to avoid confounds between the type and number of interventions a participant receives, and how to interpret interactions. The use of factorial designs in clinical intervention research poses choices that differ from those typically considered in randomized clinical trial designs. However, the great information yield of the former encourages clinical researchers' increased and careful execution of such designs. Copyright © 2017. Published by Elsevier Ltd.

  1. HTP-OligoDesigner: An Online Primer Design Tool for High-Throughput Gene Cloning and Site-Directed Mutagenesis.

    Science.gov (United States)

    Camilo, Cesar M; Lima, Gustavo M A; Maluf, Fernando V; Guido, Rafael V C; Polikarpov, Igor

    2016-01-01

    Following burgeoning genomic and transcriptomic sequencing data, biochemical and molecular biology groups worldwide are implementing high-throughput cloning and mutagenesis facilities in order to obtain a large number of soluble proteins for structural and functional characterization. Since manual primer design can be a time-consuming and error-generating step, particularly when working with hundreds of targets, the automation of primer design process becomes highly desirable. HTP-OligoDesigner was created to provide the scientific community with a simple and intuitive online primer design tool for both laboratory-scale and high-throughput projects of sequence-independent gene cloning and site-directed mutagenesis and a Tm calculator for quick queries.

  2. A Web-Based Adaptive Tutor to Teach PCR Primer Design

    Science.gov (United States)

    van Seters, Janneke R.; Wellink, Joan; Tramper, Johannes; Goedhart, Martin J.; Ossevoort, Miriam A.

    2012-01-01

    When students have varying prior knowledge, personalized instruction is desirable. One way to personalize instruction is by using adaptive e-learning to offer training of varying complexity. In this study, we developed a web-based adaptive tutor to teach PCR primer design: the PCR Tutor. We used part of the Taxonomy of Educational Objectives (the…

  3. A web-based adaptive tutor to teach PCR primer design

    NARCIS (Netherlands)

    van Seters, Janneke R.; Wellink, Joan; Tramper, Johannes; Goedhart, Martin J.; Ossevoort, Miriam A.

    2012-01-01

    When students have varying prior knowledge, personalized instruction is desirable. One way to personalize instruction is by using adaptive e-learning to offer training of varying complexity. In this study, we developed a web-based adaptive tutor to teach PCR primer design: the PCR Tutor. We used

  4. A Web-based Adaptive Tutor to Teach PCR Primer Design

    NARCIS (Netherlands)

    Seters, van J.R.; Wellink, J.; Tramper, J.; Goedhart, M.J.; Ossevoort, M.A.

    2012-01-01

    When students have varying prior knowledge, personalized instruction is desirable. One way to personalize instruction is by using adaptive e-learning to offer training of varying complexity. In this study, we developed a web-based adaptive tutor to teach PCR primer design: the PCR Tutor. We used

  5. Designing Polymerase Chain Reaction (PCR) Primer Multiplexes in the Forensic Laboratory

    Science.gov (United States)

    Elkins, Kelly M.

    2011-01-01

    The polymerase chain reaction (PCR) is a common experiment in upper-level undergraduate biochemistry, molecular biology, and forensic laboratory courses as reagents and thermocyclers have become more affordable for institutions. Typically, instructors design PCR primers to amplify the region of interest and the students prepare their samples for…

  6. Integrated Structural Design Education

    DEFF Research Database (Denmark)

    Bjerregaard Jensen, Lotte; Almegaard, Henrik

    2011-01-01

    to EU legislation. And a successful engineering student must be prepared to work in the open-ended, multidisciplinary environment necessary to produce structures which comply with EIA demands. This paper describes an innovative course developed at the Technical University of Denmark which integrates...... landscaping and structural design. The integrated courses create a setting for learning about the design of large-scale structures and involve geometry, statics, computer simulation, graphical design and landscape architecture. Together, they educate engineers who can take part in the early design phases...... of a project, function well in design teams, and comply with EU EIA demands....

  7. Integrated design of MEMS

    DEFF Research Database (Denmark)

    De Grave, Arnaud; Brissaud, Daniel

    2007-01-01

    Emerging technologies of Micro-Electromechanical Systems (MEMS) are applications such as airbag accelerometers. Micro-products present many physical differences from macro-products. Moreover, there is a high level of integration in multiple fields of physics with strongly coupled effects...... industrial immersion to propose a socio-technological description of the design process and MEMS design tools....

  8. indCAPS: A tool for designing screening primers for CRISPR/Cas9 mutagenesis events.

    Science.gov (United States)

    Hodgens, Charles; Nimchuk, Zachary L; Kieber, Joseph J

    2017-01-01

    Genetic manipulation of organisms using CRISPR/Cas9 technology generally produces small insertions/deletions (indels) that can be difficult to detect. Here, we describe a technique to easily and rapidly identify such indels. Sequence-identified mutations that alter a restriction enzyme recognition site can be readily distinguished from wild-type alleles using a cleaved amplified polymorphic sequence (CAPS) technique. If a restriction site is created or altered by the mutation such that only one allele contains the restriction site, a polymerase chain reaction (PCR) followed by a restriction digest can be used to distinguish the two alleles. However, in the case of most CRISPR-induced alleles, no such restriction sites are present in the target sequences. In this case, a derived CAPS (dCAPS) approach can be used in which mismatches are purposefully introduced in the oligonucleotide primers to create a restriction site in one, but not both, of the amplified templates. Web-based tools exist to aid dCAPS primer design, but when supplied sequences that include indels, the current tools often fail to suggest appropriate primers. Here, we report the development of a Python-based, species-agnostic web tool, called indCAPS, suitable for the design of PCR primers used in dCAPS assays that is compatible with indels. This tool should have wide utility for screening editing events following CRISPR/Cas9 mutagenesis as well as for identifying specific editing events in a pool of CRISPR-mediated mutagenesis events. This tool was field-tested in a CRISPR mutagenesis experiment targeting a cytokinin receptor (AHK3) in Arabidopsis thaliana. The tool suggested primers that successfully distinguished between wild-type and edited alleles of a target locus and facilitated the isolation of two novel ahk3 null alleles. Users can access indCAPS and design PCR primers to employ dCAPS to identify CRISPR/Cas9 alleles at http://indcaps.kieber.cloudapps.unc.edu/.

  9. An Integrated Design Process

    DEFF Research Database (Denmark)

    Petersen, Mads Dines; Knudstrup, Mary-Ann

    2010-01-01

    Present paper is placed in the discussion about how sustainable measures are integrated in the design process by architectural offices. It presents results from interviews with four leading Danish architectural offices working with sustainable architecture and their experiences with it, as well...... as the requirements they meet in terms of how to approach the design process – especially focused on the early stages like a competition. The interviews focus on their experiences with working in multidisciplinary teams and using digital tools to support their work with sustainable issues. The interviews show...... the environmental measures cannot be discarded due to extra costs....

  10. Integrated Energy Design

    DEFF Research Database (Denmark)

    Brunsgaard, Camilla; Dvořáková, Pavla; Wyckmans, Annemie

    2014-01-01

    the development, it is essential that educational institutions foster professionals with such knowledge, skills and competences. An initiative toward this direction is the EUproject of IDES-EDU: “Master and Post-Graduate education and training in multi-disciplinary teams”. The paper describes the necessity...... of more integrated and cross-disciplinary approaches to building design through state-of-the-art of the building sector and educational initiatives in the participating countries in the project, and through theory of design processes. The paper also communicates the results of newly developed cross...

  11. Fusion primer and nested integrated PCR (FPNI-PCR: a new high-efficiency strategy for rapid chromosome walking or flanking sequence cloning

    Directory of Open Access Journals (Sweden)

    Wang Zhen

    2011-11-01

    Full Text Available Abstract Background The advent of genomics-based technologies has revolutionized many fields of biological enquiry. However, chromosome walking or flanking sequence cloning is still a necessary and important procedure to determining gene structure. Such methods are used to identify T-DNA insertion sites and so are especially relevant for organisms where large T-DNA insertion libraries have been created, such as rice and Arabidopsis. The currently available methods for flanking sequence cloning, including the popular TAIL-PCR technique, are relatively laborious and slow. Results Here, we report a simple and effective fusion primer and nested integrated PCR method (FPNI-PCR for the identification and cloning of unknown genomic regions flanked known sequences. In brief, a set of universal primers was designed that consisted of various 15-16 base arbitrary degenerate oligonucleotides. These arbitrary degenerate primers were fused to the 3' end of an adaptor oligonucleotide which provided a known sequence without degenerate nucleotides, thereby forming the fusion primers (FPs. These fusion primers are employed in the first step of an integrated nested PCR strategy which defines the overall FPNI-PCR protocol. In order to demonstrate the efficacy of this novel strategy, we have successfully used it to isolate multiple genomic sequences namely, 21 orthologs of genes in various species of Rosaceace, 4 MYB genes of Rosa rugosa, 3 promoters of transcription factors of Petunia hybrida, and 4 flanking sequences of T-DNA insertion sites in transgenic tobacco lines and 6 specific genes from sequenced genome of rice and Arabidopsis. Conclusions The successful amplification of target products through FPNI-PCR verified that this novel strategy is an effective, low cost and simple procedure. Furthermore, FPNI-PCR represents a more sensitive, rapid and accurate technique than the established TAIL-PCR and hiTAIL-PCR procedures.

  12. GLobal Integrated Design Environment

    Science.gov (United States)

    Kunkel, Matthew; McGuire, Melissa; Smith, David A.; Gefert, Leon P.

    2011-01-01

    The GLobal Integrated Design Environment (GLIDE) is a collaborative engineering application built to resolve the design session issues of real-time passing of data between multiple discipline experts in a collaborative environment. Utilizing Web protocols and multiple programming languages, GLIDE allows engineers to use the applications to which they are accustomed in this case, Excel to send and receive datasets via the Internet to a database-driven Web server. Traditionally, a collaborative design session consists of one or more engineers representing each discipline meeting together in a single location. The discipline leads exchange parameters and iterate through their respective processes to converge on an acceptable dataset. In cases in which the engineers are unable to meet, their parameters are passed via e-mail, telephone, facsimile, or even postal mail. The result of this slow process of data exchange would elongate a design session to weeks or even months. While the iterative process remains in place, software can now exchange parameters securely and efficiently, while at the same time allowing for much more information about a design session to be made available. GLIDE is written in a compilation of several programming languages, including REALbasic, PHP, and Microsoft Visual Basic. GLIDE client installers are available to download for both Microsoft Windows and Macintosh systems. The GLIDE client software is compatible with Microsoft Excel 2000 or later on Windows systems, and with Microsoft Excel X or later on Macintosh systems. GLIDE follows the Client-Server paradigm, transferring encrypted and compressed data via standard Web protocols. Currently, the engineers use Excel as a front end to the GLIDE Client, as many of their custom tools run in Excel.

  13. New primers for amplification of cytochrome c oxidase subunit I barcode region designed for species of Decapoda (Crustacea

    Directory of Open Access Journals (Sweden)

    Fernando L. Mantelatto

    Full Text Available Abstract We designed 14 new primers for amplification of the COI barcode region of decapod crustacean species. We tested, with high level of success, the generation of ~ 640 ± 49 base-pair sequences in selected groups of decapods (hermit crabs, squat lobsters, marine and freshwater crabs and shrimps, encompassing representatives of 27 genera of 15 families, 11 of Pleocyemata (Anomura, Brachyura, and Caridea and 4 of Dendrobranchiata. Based on the results we expect the applicability of these primers for several studies with different taxa within Decapoda.

  14. Future integrated design environments

    DEFF Research Database (Denmark)

    Christiansson, Per; Svidt, Kjeld; Sørensen, Kristian Birch

    2009-01-01

    and modeling of explicit and implicit end-user needs and requirements on both the building to be designed and the supporting design tools. The paper provides grounds to higher success rate in capture of explicit and implicit end user needs and requirements on functional performance in use and re...

  15. Computational Design Tools for Integrated Design

    DEFF Research Database (Denmark)

    Holst, Malene Kirstine; Kirkegaard, Poul Henning

    2010-01-01

    In an architectural conceptual sketching process, where an architect is working with the initial ideas for a design, the process is characterized by three phases: sketching, evaluation and modification. Basically the architect needs to address three areas in the conceptual sketching phase......: aesthetical, functional and technical requirements. The aim of the present paper is to address the problem of a vague or not existing link between digital conceptual design tools used by architects and designers and engineering analysis and simulation tools. Based on an analysis of the architectural design...... process different digital design methods are related to tasks in an integrated design process....

  16. Employment of Near Full-Length Ribosome Gene TA-Cloning and Primer-Blast to Detect Multiple Species in a Natural Complex Microbial Community Using Species-Specific Primers Designed with Their Genome Sequences.

    Science.gov (United States)

    Zhang, Huimin; He, Hongkui; Yu, Xiujuan; Xu, Zhaohui; Zhang, Zhizhou

    2016-11-01

    It remains an unsolved problem to quantify a natural microbial community by rapidly and conveniently measuring multiple species with functional significance. Most widely used high throughput next-generation sequencing methods can only generate information mainly for genus-level taxonomic identification and quantification, and detection of multiple species in a complex microbial community is still heavily dependent on approaches based on near full-length ribosome RNA gene or genome sequence information. In this study, we used near full-length rRNA gene library sequencing plus Primer-Blast to design species-specific primers based on whole microbial genome sequences. The primers were intended to be specific at the species level within relevant microbial communities, i.e., a defined genomics background. The primers were tested with samples collected from the Daqu (also called fermentation starters) and pit mud of a traditional Chinese liquor production plant. Sixteen pairs of primers were found to be suitable for identification of individual species. Among them, seven pairs were chosen to measure the abundance of microbial species through quantitative PCR. The combination of near full-length ribosome RNA gene library sequencing and Primer-Blast may represent a broadly useful protocol to quantify multiple species in complex microbial population samples with species-specific primers.

  17. Designing of primers for detection of salmonella typhimirium and enteritidis by heminested PCR

    International Nuclear Information System (INIS)

    Ben salem, Issam

    2007-01-01

    Salmonella are the main responsible agent for the frequent food borne gastrointestinal diseases. In Tunisia, this pathogen is considered one of the most important causes of toxiinfections and its detection using classical methods is laborious and requires a large amount of time for revelation. To solve this problem, we developed a rapid molecular technique for the detection of the invA virulence gene sequence which is found in the majority of Salmonella spp. This technique is a hemi nested PCR amplification using specific primers designed and by bioinformatics tools. The detection method consisted of pre-enrichment of the sample in buffered peptone water (BPW), followed by a total DNA extraction step prior to single tube hemi nested PCR amplification. This method was found highly specific and sensitive to detect low levels of salmonella typhimurium and salmonella enteritidis (1cfu/ 25g) in naturally contaminated spicy sausage (merguez) samples. These results can benefit the public health agencies concerning microbiological and quality aspects of the commercial and traditional merguez meat production in Tunisia. (Author)

  18. Integrated circuit design using design automation

    International Nuclear Information System (INIS)

    Gwyn, C.W.

    1976-09-01

    Although the use of computer aids to develop integrated circuits is relatively new at Sandia, the program has been very successful. The results have verified the utility of the in-house CAD design capability. Custom IC's have been developed in much shorter times than available through semiconductor device manufacturers. In addition, security problems were minimized and a saving was realized in circuit cost. The custom CMOS IC's were designed at less than half the cost of designing with conventional techniques. In addition to the computer aided design, the prototype fabrication and testing capability provided by the semiconductor development laboratory and microelectronics computer network allows the circuits to be fabricated and evaluated before the designs are transferred to the commercial semiconductor manufacturers for production. The Sandia design and prototype fabrication facilities provide the capability of complete custom integrated circuit development entirely within the ERDA laboratories

  19. Applying Instructional Design Theories to Bioinformatics Education in Microarray Analysis and Primer Design Workshops

    Science.gov (United States)

    Shachak, Aviv; Ophir, Ron; Rubin, Eitan

    2005-01-01

    The need to support bioinformatics training has been widely recognized by scientists, industry, and government institutions. However, the discussion of instructional methods for teaching bioinformatics is only beginning. Here we report on a systematic attempt to design two bioinformatics workshops for graduate biology students on the basis of…

  20. Bridging the Gap: A Manual Primer into Design Computing in the Context of Basic Design Education

    Science.gov (United States)

    Uysal, V. Safak; Topaloglu, Fulden

    2017-01-01

    Design education is in need of a wider restructuring to accommodate new developments and paradigmatic shifts brought forth by the information age, all of which capitalise a move towards complexity theory, systems science and digital technologies. The intention of this article is to approach one particular aspect of this need: that is, how basic…

  1. Integrated Safety in Design

    DEFF Research Database (Denmark)

    Schultz, Casper Siebken; Jørgensen, Kirsten

    2014-01-01

    An on-going research project investigates the inclusion of health and safety considerations in the design phase as a means to achieve a higher level of health and safety in the construction industry. Moreover, the approach is coupled to the overall quality efforts. Two architectural firms and two...... consulting engineering firms are project participants. The hypothesis is that health and safety problems in execution can be prevented through better planning in the early stages of the construction processes and that accidents are prevented by providing safety. In the first stage of the research project...... a theoretical framework is developed from a combination of existing literature on health and safety and a mapping of existing practices based on interviews in all four companies. The interviews revealed that the basic knowledge on OHS among architects and engineers is limited. Also currently designers typically...

  2. Integrated Building Design

    DEFF Research Database (Denmark)

    Heiselberg, Per

    In the first half of the 20th century, HVAC systems and artificial lighting were developed to meet indoor comfort needs. Before the introduction of mechanical systems, climate - not building style or appearance - was the major determinant of building form. Comfort was achieved through passive means...... and architectural features built into the design. However, with the advent of new technologies, architects were no longer constrained by the need to ensure that buildings had ample daylighting, remained airy and cool in the summer and warm in the winter. Since HVAC systems and artificial lighting could satisfy...

  3. Beneath sci-fi sound: primer, science fiction sound design, and American independent cinema

    OpenAIRE

    Johnston, Nessa

    2012-01-01

    Primer is a very low budget science-fiction film that deals with the subject of time travel; however, it looks and sounds quite distinctively different from other films associated with the genre. While Hollywood blockbuster sci-fi relies on “sound spectacle” as a key attraction, in contrast Primer sounds “lo-fi” and screen-centred, mixed to two channel stereo rather than the now industry-standard 5.1 surround sound. Although this is partly a consequence of the economics of its production, the...

  4. Design Integration of Facilities Management

    DEFF Research Database (Denmark)

    Jensen, Per Anker

    2009-01-01

    One of the problems in the building industry is a limited degree of learning from experiences of use and operation of existing buildings. Development of professional facilities management (FM) can be seen as the missing link to bridge the gap between building operation and building design....... Strategies, methods and barriers for the transfer and integration of operational knowledge into the design process are discussed. Multiple strategies are needed to improve the integration of FM in design. Building clients must take on a leading role in defining and setting up requirements and procedures...... on literature studies and case studies from the Nordic countries in Europe, including research reflections on experiences from a main case study, where the author, before becoming a university researcher, was engaged in the client organization as deputy project director with responsibility for the integration...

  5. Integration of design and inspection

    Science.gov (United States)

    Simmonds, William H.

    1990-08-01

    Developments in advanced computer integrated manufacturing technology, coupled with the emphasis on Total Quality Management, are exposing needs for new techniques to integrate all functions from design through to support of the delivered product. One critical functional area that must be integrated into design is that embracing the measurement, inspection and test activities necessary for validation of the delivered product. This area is being tackled by a collaborative project supported by the UK Government Department of Trade and Industry. The project is aimed at developing techniques for analysing validation needs and for planning validation methods. Within the project an experimental Computer Aided Validation Expert system (CAVE) is being constructed. This operates with a generalised model of the validation process and helps with all design stages: specification of product requirements; analysis of the assurance provided by a proposed design and method of manufacture; development of the inspection and test strategy; and analysis of feedback data. The kernel of the system is a knowledge base containing knowledge of the manufacturing process capabilities and of the available inspection and test facilities. The CAVE system is being integrated into a real life advanced computer integrated manufacturing facility for demonstration and evaluation.

  6. The Integrated Design Process (IDP)

    DEFF Research Database (Denmark)

    Hansen, Hanne Tine Ring; Knudstrup, Mary-Ann

    2005-01-01

    the different parameters and products can interact, and which consequences this would have on a project. The IDP does not ensure aesthetic or sustainable solutions, but it enables the designer to control the many parameters that must be considered and integrated in the project when creating more holistic...

  7. Man-machine design integration

    Energy Technology Data Exchange (ETDEWEB)

    Carrera, J.P. [Westinghouse Electric Corp., Monroeville, PA (United States). Nuclear Technology Div.; Haentjens, J. [Westinghouse Electric Corp., Brussels (Belgium). Nuclear Technology Div.

    1995-12-31

    The presentation overviews the bases for Man-Machine Interface (MMI) designs that are part of three other presentations during the same conference: Advanced Alarm Management System, Functional Displays and System for Emergency Procedure Execution Monitoring. The MMD group history, team and goals are summarized to give some context to the core of the MMD philosophy and integration. (10 refs., 5 figs.).

  8. An integrability primer for the gauge-gravity correspondence. An introduction

    International Nuclear Information System (INIS)

    Bombardelli, Diego; Cagnazzo, Alessandra; Stockholm Univ.; KTH Royal Institute of Technology, Stockholm; Frassek, Rouven; Szecsenyi, I.M.; Levkovich-Maslyuk, Fedor; Loebbert, F.; Negro, Stefano; Sfondrini, A.; Tongeren, S.J. van; Humboldt-Univ., Berlin; Torrielli, A.

    2016-12-01

    We introduce a series of articles reviewing various aspects of integrable models relevant to the AdS/CFT correspondence. Topics covered in these reviews are: classical integrability, Yangian symmetry, factorized scattering, the Bethe ansatz, the thermodynamic Bethe ansatz, and integrable structures in (conformal) quantum field theory. In the present article we highlight how these concepts have found application in AdS/CFT, and provide a brief overview of the material contained in this series.

  9. An integrability primer for the gauge-gravity correspondence. An introduction

    Energy Technology Data Exchange (ETDEWEB)

    Bombardelli, Diego [Torino Univ. (Italy). Dipartimento di Fisica; Bologna Univ. (Italy). Dipt. die Fisica e Astronomia; INFN, Torino (Italy); INFN, Bologna (Italy); Cagnazzo, Alessandra [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Gruppe Theorie; Stockholm Univ. (Sweden); KTH Royal Institute of Technology, Stockholm (Sweden). Nordita; Frassek, Rouven; Szecsenyi, I.M. [Durham Univ. (United Kingdom). Dept. of Mathematical Sciences; Levkovich-Maslyuk, Fedor [King' s College London (United Kingdom). Mathematics Dept.; Loebbert, F. [Humboldt-Univ., Berlin (Germany). Inst. fuer Physik; Negro, Stefano [Paris 06 Univ., Sorbonne Univs., PSL Research Univ., CNRS UMR 8549 (France). LPTENS, Ecole Normale Superieure; Sfondrini, A. [ETH Zuerich (Switzerland). Inst. fuer Theoretische Physik; Tongeren, S.J. van [Humboldt-Univ., Berlin (Germany). Inst. fuer Physik; Humboldt-Univ., Berlin (Germany). Inst. fuer Mathematik; Torrielli, A. [Surrey Univ., Guildford (United Kingdom). Dept. of Mathematics

    2016-12-15

    We introduce a series of articles reviewing various aspects of integrable models relevant to the AdS/CFT correspondence. Topics covered in these reviews are: classical integrability, Yangian symmetry, factorized scattering, the Bethe ansatz, the thermodynamic Bethe ansatz, and integrable structures in (conformal) quantum field theory. In the present article we highlight how these concepts have found application in AdS/CFT, and provide a brief overview of the material contained in this series.

  10. Human Integration Design Processes (HIDP)

    Science.gov (United States)

    Boyer, Jennifer

    2014-01-01

    The purpose of the Human Integration Design Processes (HIDP) document is to provide human-systems integration design processes, including methodologies and best practices that NASA has used to meet human systems and human rating requirements for developing crewed spacecraft. HIDP content is framed around human-centered design methodologies and processes in support of human-system integration requirements and human rating. NASA-STD-3001, Space Flight Human-System Standard, is a two-volume set of National Aeronautics and Space Administration (NASA) Agency-level standards established by the Office of the Chief Health and Medical Officer, directed at minimizing health and performance risks for flight crews in human space flight programs. Volume 1 of NASA-STD-3001, Crew Health, sets standards for fitness for duty, space flight permissible exposure limits, permissible outcome limits, levels of medical care, medical diagnosis, intervention, treatment and care, and countermeasures. Volume 2 of NASASTD- 3001, Human Factors, Habitability, and Environmental Health, focuses on human physical and cognitive capabilities and limitations and defines standards for spacecraft (including orbiters, habitats, and suits), internal environments, facilities, payloads, and related equipment, hardware, and software with which the crew interfaces during space operations. The NASA Procedural Requirements (NPR) 8705.2B, Human-Rating Requirements for Space Systems, specifies the Agency's human-rating processes, procedures, and requirements. The HIDP was written to share NASA's knowledge of processes directed toward achieving human certification of a spacecraft through implementation of human-systems integration requirements. Although the HIDP speaks directly to implementation of NASA-STD-3001 and NPR 8705.2B requirements, the human-centered design, evaluation, and design processes described in this document can be applied to any set of human-systems requirements and are independent of reference

  11. QDD: a user-friendly program to select microsatellite markers and design primers from large sequencing projects.

    Science.gov (United States)

    Meglécz, Emese; Costedoat, Caroline; Dubut, Vincent; Gilles, André; Malausa, Thibaut; Pech, Nicolas; Martin, Jean-François

    2010-02-01

    QDD is an open access program providing a user-friendly tool for microsatellite detection and primer design from large sets of DNA sequences. The program is designed to deal with all steps of treatment of raw sequences obtained from pyrosequencing of enriched DNA libraries, but it is also applicable to data obtained through other sequencing methods, using FASTA files as input. The following tasks are completed by QDD: tag sorting, adapter/vector removal, elimination of redundant sequences, detection of possible genomic multicopies (duplicated loci or transposable elements), stringent selection of target microsatellites and customizable primer design. It can treat up to one million sequences of a few hundred base pairs in the tag-sorting step, and up to 50,000 sequences in a single input file for the steps involving estimation of sequence similarity. QDD is freely available under the GPL licence for Windows and Linux from the following web site: http://www.univ-provence.fr/gsite/Local/egee/dir/meglecz/QDD.html. Supplementary data are available at Bioinformatics online.

  12. Radiological controls integrated into design

    Energy Technology Data Exchange (ETDEWEB)

    Kindred, G.W. [Cleveland Electric Illuminating Co., Perry, OH (United States)

    1995-03-01

    Radiological controls are required by law in the design of commercial nuclear power reactor facilities. These controls can be relatively minor or significant, relative to cost. To ensure that radiological controls are designed into a project, the health physicist (radiological engineer) must be involved from the beginning. This is especially true regarding keeping costs down. For every radiological engineer at a nuclear power plant there must be fifty engineers of other disciplines. The radiological engineer cannot be an expert on every discipline of engineering. However, he must be knowledgeable to the degree of how a design will impact the facility from a radiological perspective. This paper will address how to effectively perform radiological analyses with the goal of radiological controls integrated into the design package.

  13. Integrated project delivery : The designer as integrator

    NARCIS (Netherlands)

    Wamelink, J.W.F.; Koolwijk, J.S.J.; van Doorn, A.J.

    2012-01-01

    Process innovation related to integrated project delivery is an important topic in the building industry. Studies on process innovation through the use of integrated contracts usually focus on contractors, and particularly on the possibility of forward integration into the building process. Three

  14. Effects of three silane primers and five adhesive agents on the bond strength of composite material for a computer-aided design and manufacturing system.

    Science.gov (United States)

    Shinohara, Ayano; Taira, Yohsuke; Sakihara, Michino; Sawase, Takashi

    2018-01-01

    Objective The objective of this study was to evaluate the effects of combinations of silane primers and adhesive agents on the bond strength of a composite block for a computer-aided design and manufacturing system. Material and Methods Three silane primers [Clearfil Ceramic Primer (CP), Super-Bond PZ Primer (PZ), and GC Ceramic Primer II (GP)] were used in conjunction with five adhesive agents [G-Premio Bond (P-Bond), Repair Adhe Adhesive (R-Adhesive), Super-Bond D-Liner Dual (SB-Dual), Super-Bond C&B (SB-Self), and SB-Dual without tributylborane derivative (SB-Light)]. The surface of a composite block (Gradia Block) was ground with silicon carbide paper. After treatment with a silane primer, a adhesive agent was applied to each testing specimen. The specimens were then bonded with a light-curing resin composite. After 24 h, the shear bond strength values were determined and compared using a post hoc test (α=0.05, n=8/group). We also prepared control specimens without primer (No primer) and/or without adhesive agent (No adhesive). Results PZ/SB-Dual and GP/SB-Dual presented the highest bond strength, followed by GP/P-Bond, CP/SB-Dual, CP/R-Adhesive, No primer/SB-Dual, GP/R-Adhesive, CP/P-Bond, No primer/R-Adhesive, PZ/R-Adhesive, CP/SB-Self, PZ/P-Bond, PZ/SB-Self, and GP/SB-Self in descending order of bond strength. No primer/P-Bond, No primer/SB-Self, and all specimens in the SB-Light and No adhesive groups presented the lowest bond strengths. Conclusion A dual-curing adhesive agent (SB-Dual) containing a tributylborane derivative in combination with a silane primer (GP or PZ) presents a greater bond strength between the composite block and the repairing resin composite than the comparators used in the study.

  15. MRI Primer

    International Nuclear Information System (INIS)

    Oldendorf, W.; Oldendorf, W. Jr.

    1991-01-01

    Designed for studies, radiologists, and clinicians at all levels of training, this book provides a basic introduction to the principles, physics, and instrumentation of magnetic resonance imaging. The fundamental concepts that are essential for the optimal clinical use of MRI are thoroughly explained in easily accessible terms. To facilitate the reader's comprehension, the material is presented nonmathematically, using no equations and a minimum of symbols and abbreviations. MRI Primer presents a clear account of the phenomenon of nuclear magnetic resonance and the use of gradient magnetic fields to create clinically useful images of cross-sectional slices. Close attention is given to the magnetization vector as a means of expressing nuclear behavior, the role of T 1 and T 2 weighing in imaging, the use of contrast agents, and the pulse sequences most often used in clinical practice, as well as to the relative capabilities and limitations of MRI and CT. The basic hardware components of an MRI scanner are described in detail. Sample MRI scans illustrate how MRI characterizes tissue. An appendix provides a brief introduction to quantum processes in MRI

  16. Optimal control of a double integrator a primer on maximum principle

    CERN Document Server

    Locatelli, Arturo

    2017-01-01

    This book provides an introductory yet rigorous treatment of Pontryagin’s Maximum Principle and its application to optimal control problems when simple and complex constraints act on state and control variables, the two classes of variable in such problems. The achievements resulting from first-order variational methods are illustrated with reference to a large number of problems that, almost universally, relate to a particular second-order, linear and time-invariant dynamical system, referred to as the double integrator. The book is ideal for students who have some knowledge of the basics of system and control theory and possess the calculus background typically taught in undergraduate curricula in engineering. Optimal control theory, of which the Maximum Principle must be considered a cornerstone, has been very popular ever since the late 1950s. However, the possibly excessive initial enthusiasm engendered by its perceived capability to solve any kind of problem gave way to its equally unjustified rejecti...

  17. Designing Critique for Knowledge Integration

    Science.gov (United States)

    Sato, Mie Elissa

    Generating explanations is central to science and has the potential to have a powerful impact on students' conceptual understanding in science instruction. However, improving conceptual understanding by generating explanations is a fraught affair: students may struggle with the sense of false clarity that may arise from generating explanations, fail to detect gaps in their understanding, and dismiss salient information that contradict their beliefs. Critiquing explanations has the potential to counteract these pitfalls by exposing students to alternative ideas to contrast with their own. This dissertation seeks to clarify how to design critique in technology-enhanced science instruction to support students in revising their explanations about scientific phenomena, and in doing so, refining their conceptual understanding. Using the Knowledge Integration framework, I revised two technology-enhanced curriculum units, Plate Tectonics and Global Climate Change, in a design partnership between teachers, researchers, and technologists. I conducted a series of studies with sixth-grade students to investigate the conditions under which guided critique of explanations can support revision. The pilot critique study investigated the impact of the revised Plate Tectonics unit on students' understanding of convection, as well as of a preliminary design of critique where students generated and applied their own criteria for what makes a good explanation in science. The guidance study explored how incorporating a complex selection task that features meta-explanatory criteria into critique supports students in distinguishing among different criteria, as well as how students use peer or expert guidance on their initial explanation during revision. The critique study investigated how designing critique with a complex selection task that features plausible alternative ideas and giving guidance on students' critiques support students in distinguishing among a range of relevant ideas

  18. High Integrity Can Design Interfaces

    International Nuclear Information System (INIS)

    Shaber, E.L.

    1998-01-01

    The National Spent Nuclear Fuel Program is chartered with facilitating the disposition of DOE-owned spent nuclear fuel to allow disposal at a geologic repository. This is done through coordination with the repository program and by assisting DOE Site owners of SNF with needed information, standardized requirements, packaging approaches, etc. The High Integrity Can (HIC) will be manufactured to provide a substitute or barrier enhancement for normal fuel geometry and cladding. The can would be nested inside the DOE standardized canister which is designed to interface with the repository waste package. The HIC approach may provide the following benefits over typical canning approaches for DOE SNF. (a) It allows ready calculation and management of criticality issues for miscellaneous. (b) It segments and further isolates damaged or otherwise problem materials from normal SNF in the repository package. (c) It provides a very long term corrosion barrier. (d) It provides an extra internal pressure barrier for particulates, gaseous fission products, hydrogen, and water vapor. (e) It delays any potential release of fission products to the repository environment. (f) It maintains an additional level of fuel geometry control during design basis accidents, rock-fall, and seismic events. (g) When seal welded, it could provide the additional containment required for shipments involving plutonium content in excess of 20 Ci. (10 CFR 71.63.b) if integrated with an appropriate cask design. Long term corrosion protection is central to the HIC concept. The material selected for the HIC (Hastelloy C-22) has undergone extensive testing for repository service. The most severe theoretical interactions between iron, repository water containing chlorides and other repository construction materials have been tested. These expected chemical species have not been shown capable of corroding the selected HIC material. Therefore, the HIC should provide a significant barrier to DOE SNF dispersal

  19. Academic Primer Series: Five Key Papers about Study Designs in Medical Education.

    Science.gov (United States)

    Gottlieb, Michael; Chan, Teresa M; Fredette, Jenna; Messman, Anne; Robinson, Daniel W; Cooney, Robert; Boysen-Osborn, Megan; Sherbino, Jonathan

    2017-06-01

    A proper understanding of study design is essential to creating successful studies. This is also important when reading or peer reviewing publications. In this article, we aimed to identify and summarize key papers that would be helpful for faculty members interested in learning more about study design in medical education research. The online discussions of the 2016-2017 Academic Life in Emergency Medicine Faculty Incubator program included a robust and vigorous discussion about education study design, which highlighted a number of papers on that topic. We augmented this list of papers with further suggestions by expert mentors. Via this process, we created a list of 29 papers in total on the topic of medical education study design. After gathering these papers, our authorship group engaged in a modified Delphi approach to build consensus on the papers that were most valuable for the understanding of proper study design in medical education. We selected the top five most highly rated papers on the topic domain of study design as determined by our study group. We subsequently summarized these papers with respect to their relevance to junior faculty members and to faculty developers. This article summarizes five key papers addressing study design in medical education with discussions and applications for junior faculty members and faculty developers. These papers provide a basis upon which junior faculty members might build for developing and analyzing studies.

  20. Protein folding and non-conventional drug design: a primer for nuclear structure physicists

    International Nuclear Information System (INIS)

    Broglia, R.A.; Tiana, G.; Provasi, D.

    2004-01-01

    Some of the paradigms emerging from the study of the phenomena of phase transitions in finite many-body systems, like e.g. the atomic nucleus can be used at profit to solve the protein folding problem within the framework of simple (although not oversimplified) models. From this solution a paradigm emerges for the design of non-conventional drugs, which inhibit enzymatic action without inducing resistance (mutations). The application of these concepts to the design of an inhibitor to the HIV-protease central in the life cycle of the HIV virus is discussed

  1. Integrated Radiation Analysis and Design Tools

    Data.gov (United States)

    National Aeronautics and Space Administration — The Integrated Radiation Analysis and Design Tools (IRADT) Project develops and maintains an integrated tool set that collects the current best practices, databases,...

  2. Understanding the internet, website design and intranet development: a primer for radiologists

    Energy Technology Data Exchange (ETDEWEB)

    Perriss, R.W. [Department of Radiology, John Radcliffe Hospital, Headington, Oxford (United Kingdom); Graham, R.N.J. [Department of Radiology, John Radcliffe Hospital, Headington, Oxford (United Kingdom); Scarsbrook, A.F. [Department of Radiology, John Radcliffe Hospital, Headington, Oxford (United Kingdom)]. E-mail: andyscarsbrook1@aol.com

    2006-05-15

    The internet has become an essential part of daily life for almost all radiologists and yet few fully understand how this works or how best to harness the technology within the workplace. This article will explore the basics of computer networking which has allowed the internet to become a valuable resource. In addition, the process of designing and implementing a website or intranet site for the benefit of radiology departmental administration and education will be discussed. The options of how to develop a website, what to include, and how to achieve this using easy to use, freely available and low-cost software will also be explored.

  3. Understanding the internet, website design and intranet development: a primer for radiologists

    International Nuclear Information System (INIS)

    Perriss, R.W.; Graham, R.N.J.; Scarsbrook, A.F.

    2006-01-01

    The internet has become an essential part of daily life for almost all radiologists and yet few fully understand how this works or how best to harness the technology within the workplace. This article will explore the basics of computer networking which has allowed the internet to become a valuable resource. In addition, the process of designing and implementing a website or intranet site for the benefit of radiology departmental administration and education will be discussed. The options of how to develop a website, what to include, and how to achieve this using easy to use, freely available and low-cost software will also be explored

  4. Assessment of SCAR markers to design real-time PCR primers for rhizosphere quantification of Azospirillum brasilense phytostimulatory inoculants of maize.

    Science.gov (United States)

    Couillerot, O; Poirier, M-A; Prigent-Combaret, C; Mavingui, P; Caballero-Mellado, J; Moënne-Loccoz, Y

    2010-08-01

    To assess the applicability of sequence characterized amplified region (SCAR) markers obtained from BOX, ERIC and RAPD fragments to design primers for real-time PCR quantification of the phytostimulatory maize inoculants Azospirillum brasilense UAP-154 and CFN-535 in the rhizosphere. Primers were designed based on strain-specific SCAR markers and were screened for successful amplification of target strain and absence of cross-reaction with other Azospirillum strains. The specificity of primers thus selected was verified under real-time PCR conditions using genomic DNA from strain collection and DNA from rhizosphere samples. The detection limit was 60 fg DNA with pure cultures and 4 x 10(3) (for UAP-154) and 4 x 10(4) CFU g(-1) (for CFN-535) in the maize rhizosphere. Inoculant quantification was effective from 10(4) to 10(8) CFU g(-1) soil. BOX-based SCAR markers were useful to find primers for strain-specific real-time PCR quantification of each A. brasilense inoculant in the maize rhizosphere. Effective root colonization is a prerequisite for successful Azospirillum phytostimulation, but cultivation-independent monitoring methods were lacking. The real-time PCR methods developed here will help understand the effect of environmental conditions on root colonization and phytostimulation by A. brasilense UAP-154 and CFN-535.

  5. Integrating reliability analysis and design

    International Nuclear Information System (INIS)

    Rasmuson, D.M.

    1980-10-01

    This report describes the Interactive Reliability Analysis Project and demonstrates the advantages of using computer-aided design systems (CADS) in reliability analysis. Common cause failure problems require presentations of systems, analysis of fault trees, and evaluation of solutions to these. Results have to be communicated between the reliability analyst and the system designer. Using a computer-aided design system saves time and money in the analysis of design. Computer-aided design systems lend themselves to cable routing, valve and switch lists, pipe routing, and other component studies. At EG and G Idaho, Inc., the Applicon CADS is being applied to the study of water reactor safety systems

  6. Integrated design for space transportation system

    CERN Document Server

    Suresh, B N

    2015-01-01

    The book addresses the overall integrated design aspects of a space transportation system involving several disciplines like propulsion, vehicle structures, aerodynamics, flight mechanics, navigation, guidance and control systems, stage auxiliary systems, thermal systems etc. and discusses the system approach for design, trade off analysis, system life cycle considerations, important aspects in mission management, the risk assessment, etc. There are several books authored to describe the design aspects of various areas, viz., propulsion, aerodynamics, structures, control, etc., but there is no book which presents space transportation system (STS) design in an integrated manner. This book attempts to fill this gap by addressing systems approach for STS design, highlighting the integrated design aspects, interactions between various subsystems and interdependencies. The main focus is towards the complex integrated design to arrive at an optimum, robust and cost effective space transportation system. The orbit...

  7. Challenges of Aircraft Design Integration

    Science.gov (United States)

    2003-03-01

    predicted by the conceptual stick model and the full FEM of the Challenger wing without winglets . Advanced aerodynamic wing design methods To design wings...Piperni, E. Laurendeau Advanced Aerodynamics Bombardier Aerospace 400 CMte Vertu Road Dorval, Quebec, Canada, H4S 1Y9 Fassi.Kafyeke @notes.canadair.ca Tel...514) 855-7186 Abstract The design of a modern airplane brings together many disciplines: structures, aerodynamics , controls, systems, propulsion

  8. Passive solar offices: integrated design

    Energy Technology Data Exchange (ETDEWEB)

    Evans, B

    1992-05-06

    Passive solar design in out-of-town offices can remove the need for air-conditioning by making greater use of daylight and natural ventilation. To promote the use of passive solar energy a series of design studies are being run by the Energy Technology Support Unit on behalf of the Department of Energy. The three reported here are designs for out-of-town business buildings. Each is a hypothetical building designed to a realistic brief for an organisation taking the role of real client. (author).

  9. Laser and photonic systems design and integration

    CERN Document Server

    Nof, Shimon Y; Cheng, Gary J

    2014-01-01

    New, significant scientific discoveries in laser and photonic technologies, systems perspectives, and integrated design approaches can improve even further the impact in critical areas of challenge. Yet this knowledge is dispersed across several disciplines and research arenas. Laser and Photonic Systems: Design and Integration brings together a multidisciplinary group of experts to increase understanding of the ways in which systems perspectives may influence laser and photonic innovations and application integration.By bringing together chapters from leading scientists and technologists, ind

  10. Integrating product design into the supply chain

    DEFF Research Database (Denmark)

    Khan, Omera; Stolte, Terje; Creazza, Alessandro

    2016-01-01

    Purpose: The aim of the research is to illustrate how companies can create competitive capabilities through integration of product design into the supply chain. In doing so the paper reveals the challenges and the opportunities that companies face when integrating product design and supply chain...... of opportunities and challenges when integrating product design and the supply chain and subsequently a step-by-step guide is developed to address these. Practical Implications: The research provides key recommendations to companies on how to create competitive capabilities by integrating product design...... into the supply chain. Originality/Value: This paper provides novel insights to both practitioners and researchers. For practitioners detailed recommendations are given on how they can maximise benefits through integrating product design into the supply chain. The RBV has been harnessed to highlight how...

  11. Integrating product design into the supply chain

    DEFF Research Database (Denmark)

    Khan, Omera; Stolte, Terje; Creazza, Alessandro

    2016-01-01

    into the supply chain. Originality/Value: This paper provides novel insights to both practitioners and researchers. For practitioners detailed recommendations are given on how they can maximise benefits through integrating product design into the supply chain. The RBV has been harnessed to highlight how......Purpose: The aim of the research is to illustrate how companies can create competitive capabilities through integration of product design into the supply chain. In doing so the paper reveals the challenges and the opportunities that companies face when integrating product design and supply chain...... of opportunities and challenges when integrating product design and the supply chain and subsequently a step-by-step guide is developed to address these. Practical Implications: The research provides key recommendations to companies on how to create competitive capabilities by integrating product design...

  12. Integrating ergonomic knowledge into engineering design processes

    DEFF Research Database (Denmark)

    Hall-Andersen, Lene Bjerg

    Integrating ergonomic knowledge into engineering design processes has been shown to contribute to healthy and effective designs of workplaces. However, it is also well-recognized that, in practice, ergonomists often have difficulties gaining access to and impacting engineering design processes...... employed in the same company, constituted a supporting factor for the possibilities to integrate ergonomic knowledge into the engineering design processes. However, the integration activities remained discrete and only happened in some of the design projects. A major barrier was related to the business...... to the ergonomic ambitions of the clients. The ergonomists’ ability to navigate, act strategically, and compromise on ergonomic inputs is also important in relation to having an impact in the engineering design processes. Familiarity with the engineering design terminology and the setup of design projects seems...

  13. Estimates of abundance and diversity of Shewanella genus in natural and engineered aqueous environments with newly designed primers.

    Science.gov (United States)

    Li, Bing-Bing; Cheng, Yuan-Yuan; Fan, Yang-Yang; Liu, Dong-Feng; Fang, Cai-Yun; Wu, Chao; Li, Wen-Wei; Yang, Zong-Chuang; Yu, Han-Qing

    2018-05-12

    Shewanella species have a diverse respiratory ability and wide distribution in environments and play an important role in bioremediation and the biogeochemical cycles of elements. Primers with more accuracy and broader coverage are required with consideration of the increasing number of Shewanella species and evaluation of their roles in various environments. In this work, a new primer set of 640F/815R was developed to quantify the abundance of Shewanella species in natural and engineered environments. In silico tools for primer evaluation, quantitative polymerase chain reaction (qPCR) and clone library results showed that 640F/815R had a higher specificity and coverage than the previous primers in quantitative analysis of Shewanella. Another newly developed primer pair of 211F/815cR was also adopted to analyze the Shewanella diversity and demonstrated to be the best candidate in terms of specificity and coverage. We detected more Shewanella-related species in freshwater environments and found them to be substantially different from those in marine environments. Abundance and diversity of Shewanella species in wastewater treatment plants were largely affected by the process and operating conditions. Overall, this study suggests that investigations of abundance and diversity of Shewanella in various environments are of great importance to evaluate their ecophysiology and potential ecological roles. Copyright © 2018 Elsevier B.V. All rights reserved.

  14. Simple sequence repeat marker loci discovery using SSR primer.

    Science.gov (United States)

    Robinson, Andrew J; Love, Christopher G; Batley, Jacqueline; Barker, Gary; Edwards, David

    2004-06-12

    Simple sequence repeats (SSRs) have become important molecular markers for a broad range of applications, such as genome mapping and characterization, phenotype mapping, marker assisted selection of crop plants and a range of molecular ecology and diversity studies. With the increase in the availability of DNA sequence information, an automated process to identify and design PCR primers for amplification of SSR loci would be a useful tool in plant breeding programs. We report an application that integrates SPUTNIK, an SSR repeat finder, with Primer3, a PCR primer design program, into one pipeline tool, SSR Primer. On submission of multiple FASTA formatted sequences, the script screens each sequence for SSRs using SPUTNIK. The results are parsed to Primer3 for locus-specific primer design. The script makes use of a Web-based interface, enabling remote use. This program has been written in PERL and is freely available for non-commercial users by request from the authors. The Web-based version may be accessed at http://hornbill.cspp.latrobe.edu.au/

  15. Efectos de una metodología integral en el aprendizaje de la geometría en alumnos de primer semestre de ingenierías

    OpenAIRE

    Rojas, Carlos

    2007-01-01

    El presente estudio tuvo como objetivo determinar el efecto de una metodología, que se denominó integral, sobre el aprendizaje de la geometría en dos grupos de alumnos de primer semestre de ingenierías de la Universidad del Norte. Dicha metodología consistió en: los sistemas de representación de Bruner, como estrategia en el aprendizaje de conceptos y teoremas; los mentefactos, como instrumento en el aprendizaje conceptual; la argumentación deductiva en la respuesta a preguntas, y un heurísti...

  16. Decision-Based Design Integrating Consumer Preferences into Engineering Design

    CERN Document Server

    Chen, Wei; Wassenaar, Henk Jan

    2013-01-01

    Building upon the fundamental principles of decision theory, Decision-Based Design: Integrating Consumer Preferences into Engineering Design presents an analytical approach to enterprise-driven Decision-Based Design (DBD) as a rigorous framework for decision making in engineering design.  Once the related fundamentals of decision theory, economic analysis, and econometrics modelling are established, the remaining chapters describe the entire process, the associated analytical techniques, and the design case studies for integrating consumer preference modeling into the enterprise-driven DBD framework. Methods for identifying key attributes, optimal design of human appraisal experiments, data collection, data analysis, and demand model estimation are presented and illustrated using engineering design case studies. The scope of the chapters also provides: •A rigorous framework of integrating the interests from both producer and consumers in engineering design, •Analytical techniques of consumer choice model...

  17. Simulation Integrated Design for Logistics

    NARCIS (Netherlands)

    Veeke, H.P.M.

    2003-01-01

    The design of an innovative logistic system is a complex problem in the solution of which many disciplines are involved. Each discipline developed its own way of conceptual modeling for a logistic system based on a mono disciplinary perception. In essence this leads to a communication problem

  18. Semiconductors integrated circuit design for manufacturability

    CERN Document Server

    Balasinki, Artur

    2011-01-01

    Because of the continuous evolution of integrated circuit manufacturing (ICM) and design for manufacturability (DfM), most books on the subject are obsolete before they even go to press. That's why the field requires a reference that takes the focus off of numbers and concentrates more on larger economic concepts than on technical details. Semiconductors: Integrated Circuit Design for Manufacturability covers the gradual evolution of integrated circuit design (ICD) as a basis to propose strategies for improving return-on-investment (ROI) for ICD in manufacturing. Where most books put the spotl

  19. Three Course Connections: Integrated Event Design

    Science.gov (United States)

    Johnson, Corey W.; Pate, Joseph A.

    2013-01-01

    Integrated Event Design (IED) capitalizes on three distinct courses to achieve a blended course delivery: Event Management, Research and Evaluation (for undergraduate students), and Experiential Education (for graduate students). Through the use of an event management company metaphor that fully integrates the diverse curricular concepts, course…

  20. Integrated NTP Vehicle Radiation Design

    Science.gov (United States)

    Caffrey, Jarvis; Rodriquez, Mitchell

    2018-01-01

    The development of a nuclear thermal propulsion stage requires consideration for radiation emitted from the nuclear reactor core. Applying shielding mass is an effective mitigating solution, but a better alternative is to incorporate some mitigation strategies into the propulsion stage and crew habitat. In this way, the required additional mass is minimized and the mass that must be applied may in some cases be able to serve multiple purposes. Strategies for crew compartment shielding are discussed that reduce dose from both engine and cosmic sources, and in some cases may also serve to reduce life support risks by permitting abundant water reserves. Early consideration for integrated mitigation solutions in a crewed nuclear thermal propulsion (NTP) vehicle will enable reduced radiation burden from both cosmic and nuclear sources, improved thrust-to-weight ratio or payload capacity by reducing 'dead mass' of shielding, and generally support a more robust risk posture for a NTP-powered Mars mission by permitting shorter trip times and increased water reserves

  1. Integrated NTP Vehicle Radiation Design

    Science.gov (United States)

    Caffrey, Jarvis A.; Rodriquez, Mitchell A.

    2018-01-01

    The development of a nuclear thermal propulsion stage requires consideration for radiation emitted from the nuclear reactor core. Applying shielding mass is an effective mitigating solution, but a better alternative is to incorporate some mitigation strategies into the propulsion stage and crew habitat. In this way, the required additional mass is minimized and the mass that must be applied may in some cases be able to serve multiple purposes. Strategies for crew compartment shielding are discussed that reduce dose from both engine and cosmic sources, and in some cases may also serve to reduce life support risks by permitting abundant water reserves. Early consideration for integrated mitigation solutions in a crewed nuclear thermal propulsion (NTP) vehicle will enable reduced radiation burden from both cosmic and nuclear sources, improved thrust-to-weight ratio or payload capacity by reducing 'dead mass' of shielding, and generally support a more robust risk posture for a NTP-powered Mars mission by permitting shorter trip times and increased water reserves.

  2. An analog integrated circuit design laboratory

    OpenAIRE

    Mondragon-Torres, A.F.; Mayhugh, Jr.; Pineda de Gyvez, J.; Silva-Martinez, J.; Sanchez-Sinencio, E.

    2003-01-01

    We present the structure of an analog integrated circuit design laboratory to instruct at both, senior undergraduate and entry graduate levels. The teaching material includes: a laboratory manual with analog circuit design theory, pre-laboratory exercises and circuit design specifications; a reference web page with step by step instructions and examples; the use of mathematical tools for automation and analysis; and state of the art CAD design tools in use by industry. Upon completion of the ...

  3. Innovative Comparison of Transient Ignition Temperature at the Booster Interface, New Stainless Steel Pyrovalve Primer Chamber Assembly "V" (PCA) Design Versus the Current Aluminum "Y" PCA Design

    Science.gov (United States)

    Saulsberry, Regor L.; McDougle, Stephen H.; Garcia,Roberto; Johnson, Kenneth L.; Sipes, William; Rickman, Steven; Hosangadi, Ashvin

    2011-01-01

    An assessment of four spacecraft pyrovalve anomalies that occurred during ground testing was conducted by the NASA Engineering & Safety Center (NESC) in 2008. In all four cases, a common aluminum (Al) primer chamber assembly (PCA) was used with dual NASA Standard Initiators (NSIs) and the nearly simultaneous (separated by less than 80 microseconds) firing of both initiators failed to ignite the booster charge. The results of the assessment and associated test program were reported in AIAA Paper AIAA-2008-4798, NESC Independent Assessment of Pyrovalve Ground Test Anomalies. As a result of the four Al PCA anomalies, and the test results and findings of the NESC assessment, the Mars Science Laboratory (MSL) project team decided to make changes to the PCA. The material for the PCA body was changed from aluminum (Al) to stainless steel (SS) to avoid melting, distortion, and potential leakage of the NSI flow passages when the device functioned. The flow passages, which were interconnected in a Y-shaped configuration (Y-PCA) in the original design, were changed to a V-shaped configuration (V-PCA). The V-shape was used to more efficiently transfer energy from the NSIs to the booster. Development and qualification testing of the new design clearly demonstrated faster booster ignition times compared to the legacy AL Y-PCA design. However, the final NESC assessment report recommended that the SS V-PCA be experimentally characterized and quantitatively compared to the Al Y-PCA design. This data was deemed important for properly evaluating the design options for future NASA projects. This test program has successfully quantified the improvement of the SS V-PCA over the Al Y-PCA. A phase B of the project was also conducted and evaluated the effect of firing command skew and enlargement of flame channels to further assist spacecraft applications.

  4. Aircraft System Design and Integration

    Directory of Open Access Journals (Sweden)

    D. P. Coldbeck

    2000-01-01

    Full Text Available In the 1980's the British aircraft industry changed its approach to the management of projects from a system where a project office would manage a project and rely on a series of specialist departments to support them to a more process oriented method, using systems engineering models, whose most outwardly visible signs were the introduction of multidisciplinary product teams. One of the problems with the old method was that the individual departments often had different priorities and projects would get uneven support. The change in the system was only made possible for complex designs by the electronic distribution of data giving instantaneous access to all involved in the project. In 1997 the Defence and Aerospace Foresight Panel emphasised the need for a system engineering approach if British industry was to remain competitive. The Royal Academy of Engineering recognised that the change in working practices also changed what was required of a chartered engineer and redefined their requirements in 1997 [1]. The result of this is that engineering degree courses are now judged against new criteria with more emphasis placed on the relevance to industry rather than on purely academic content. At the University of Glasgow it was realized that the students ought to be made aware of current working practices and that there ought to be a review to ensure that the degrees give students the skills required by industry. It was decided to produce a one week introduction course in systems engineering for Masters of Engineering (MEng students to be taught by both university lecturers and practitioners from a range of companies in the aerospace industry with the hope of expanding the course into a module. The reaction of the students was favourable in terms of the content but it seems ironic that the main criticism was that there was not enough discussion involving the students. This paper briefly describes the individual teaching modules and discusses the

  5. Teaching Process Design through Integrated Process Synthesis

    Science.gov (United States)

    Metzger, Matthew J.; Glasser, Benjamin J.; Patel, Bilal; Hildebrandt, Diane; Glasser, David

    2012-01-01

    The design course is an integral part of chemical engineering education. A novel approach to the design course was recently introduced at the University of the Witwatersrand, Johannesburg, South Africa. The course aimed to introduce students to systematic tools and techniques for setting and evaluating performance targets for processes, as well as…

  6. Integrating sustainability in interior design studio

    OpenAIRE

    Karslı, Umut Tuğlu

    2013-01-01

    Teaching methods on concept of sustainability are frequently searched in the interior architecture education. The purpose of this study is to propose a model for integrating sustainability in interior design studio. In this context, the first part of the research defines relationship between sustainability and interior architecture and determines sustainable interior design principles. In the second part, an interior design studio model is proposed and principles determined in the first part ...

  7. Behavioural design: A process for integrating behaviour change and design

    DEFF Research Database (Denmark)

    Cash, Philip; Hartlev, Charlotte Gram; Durazo, Christine Boysen

    2017-01-01

    Nudge, persuasion, and the influencing of human behaviour through design are increasingly important topics in design research and in the wider public consciousness. However, current theoretical approaches to behaviour change have yet to be operationalized this in design process support....... Specifically, there are few empirically grounded processes supporting designers in realising behaviour change projects. In response to this, 20 design projects from a case company are analysed in order to distil a core process for behavioural design. Results show a number of process stages and activities...... associated with project success, pointing to a new perspective on the traditional design process, and allowing designers to integrate key insights from behaviour change theory. Using this foundation we propose the Behavioural Design process....

  8. Power management techniques for integrated circuit design

    CERN Document Server

    Chen, Ke-Horng

    2016-01-01

    This book begins with the premise that energy demands are directing scientists towards ever-greener methods of power management, so highly integrated power control ICs (integrated chip/circuit) are increasingly in demand for further reducing power consumption. * A timely and comprehensive reference guide for IC designers dealing with the increasingly widespread demand for integrated low power management * Includes new topics such as LED lighting, fast transient response, DVS-tracking and design with advanced technology nodes * Leading author (Chen) is an active and renowned contributor to the power management IC design field, and has extensive industry experience * Accompanying website includes presentation files with book illustrations, lecture notes, simulation circuits, solution manuals, instructors manuals, and program downloads.

  9. Integrated plant information technology design support functionality

    International Nuclear Information System (INIS)

    Kim, Yeon Seung; Kim, Dae Jin; Barber, P. W.; Goland, D.

    1996-06-01

    This technical report was written as a result of Integrated Plant Information System (IPIS) feasibility study on CANDU 9 project which had been carried out from January, 1994 to March, 1994 at AECL (Atomic Energy Canada Limited) in Canada. From 1987, AECL had done endeavour to change engineering work process from paper based work process to computer based work process through CANDU 3 project. Even though AECL had a lot of good results form computerizing the Process Engineering, Instrumentation Control and Electrical Engineering, Mechanical Engineering, Computer Aided Design and Drafting, and Document Management System, but there remains the problem of information isolation and integration. On this feasibility study, IPIS design support functionality guideline was suggested by evaluating current AECL CAE tools, analyzing computer aided engineering task and work flow, investigating request for implementing integrated computer aided engineering and describing Korean request for future CANDU design including CANDU 9. 6 figs. (Author)

  10. Integrated plant information technology design support functionality

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yeon Seung; Kim, Dae Jin [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); Barber, P W; Goland, D [Atomic Energy Canada Ltd., (Canada)

    1996-06-01

    This technical report was written as a result of Integrated Plant Information System (IPIS) feasibility study on CANDU 9 project which had been carried out from January, 1994 to March, 1994 at AECL (Atomic Energy Canada Limited) in Canada. From 1987, AECL had done endeavour to change engineering work process from paper based work process to computer based work process through CANDU 3 project. Even though AECL had a lot of good results form computerizing the Process Engineering, Instrumentation Control and Electrical Engineering, Mechanical Engineering, Computer Aided Design and Drafting, and Document Management System, but there remains the problem of information isolation and integration. On this feasibility study, IPIS design support functionality guideline was suggested by evaluating current AECL CAE tools, analyzing computer aided engineering task and work flow, investigating request for implementing integrated computer aided engineering and describing Korean request for future CANDU design including CANDU 9. 6 figs. (Author).

  11. Design of analog integrated circuits and systems

    CERN Document Server

    Laker, Kenneth R

    1994-01-01

    This text is designed for senior or graduate level courses in analog integrated circuits or design of analog integrated circuits. This book combines consideration of CMOS and bipolar circuits into a unified treatment. Also included are CMOS-bipolar circuits made possible by BiCMOS technology. The text progresses from MOS and bipolar device modelling to simple one and two transistor building block circuits. The final two chapters present a unified coverage of sample-data and continuous-time signal processing systems.

  12. SUBSURFACE REPOSITORY INTEGRATED CONTROL SYSTEM DESIGN

    International Nuclear Information System (INIS)

    Randle, D.C.

    2000-01-01

    The primary purpose of this document is to develop a preliminary high-level functional and physical control system architecture for the potential repository at Yucca Mountain. This document outlines an overall control system concept that encompasses and integrates the many diverse process and communication systems being developed for the subsurface repository design. This document presents integrated design concepts for monitoring and controlling the diverse set of subsurface operations. The Subsurface Repository Integrated Control System design will be composed of a series of diverse process systems and communication networks. The subsurface repository design contains many systems related to instrumentation and control (I andC) for both repository development and waste emplacement operations. These systems include waste emplacement, waste retrieval, ventilation, radiological and air monitoring, rail transportation, construction development, utility systems (electrical, lighting, water, compressed air, etc.), fire protection, backfill emplacement, and performance confirmation. Each of these systems involves some level of I andC and will typically be integrated over a data communications network throughout the subsurface facility. The subsurface I andC systems will also interface with multiple surface-based systems such as site operations, rail transportation, security and safeguards, and electrical/piped utilities. In addition to the I andC systems, the subsurface repository design also contains systems related to voice and video communications. The components for each of these systems will be distributed and linked over voice and video communication networks throughout the subsurface facility. The scope and primary objectives of this design analysis are to: (1) Identify preliminary system-level functions and interfaces (Section 6.2). (2) Examine the overall system complexity and determine how and on what levels the engineered process systems will be monitored

  13. Coal Bed Methane Primer

    Energy Technology Data Exchange (ETDEWEB)

    Dan Arthur; Bruce Langhus; Jon Seekins

    2005-05-25

    During the second half of the 1990's Coal Bed Methane (CBM) production increased dramatically nationwide to represent a significant new source of income and natural gas for many independent and established producers. Matching these soaring production rates during this period was a heightened public awareness of environmental concerns. These concerns left unexplained and under-addressed have created a significant growth in public involvement generating literally thousands of unfocused project comments for various regional NEPA efforts resulting in the delayed development of public and fee lands. The accelerating interest in CBM development coupled to the growth in public involvement has prompted the conceptualization of this project for the development of a CBM Primer. The Primer is designed to serve as a summary document, which introduces and encapsulates information pertinent to the development of Coal Bed Methane (CBM), including focused discussions of coal deposits, methane as a natural formed gas, split mineral estates, development techniques, operational issues, producing methods, applicable regulatory frameworks, land and resource management, mitigation measures, preparation of project plans, data availability, Indian Trust issues and relevant environmental technologies. An important aspect of gaining access to federal, state, tribal, or fee lands involves education of a broad array of stakeholders, including land and mineral owners, regulators, conservationists, tribal governments, special interest groups, and numerous others that could be impacted by the development of coal bed methane. Perhaps the most crucial aspect of successfully developing CBM resources is stakeholder education. Currently, an inconsistent picture of CBM exists. There is a significant lack of understanding on the parts of nearly all stakeholders, including industry, government, special interest groups, and land owners. It is envisioned the Primer would being used by a variety of

  14. Predictive maintenance primer

    International Nuclear Information System (INIS)

    Flude, J.W.; Nicholas, J.R.

    1991-04-01

    This Predictive Maintenance Primer provides utility plant personnel with a single-source reference to predictive maintenance analysis methods and technologies used successfully by utilities and other industries. It is intended to be a ready reference to personnel considering starting, expanding or improving a predictive maintenance program. This Primer includes a discussion of various analysis methods and how they overlap and interrelate. Additionally, eighteen predictive maintenance technologies are discussed in sufficient detail for the user to evaluate the potential of each technology for specific applications. This document is designed to allow inclusion of additional technologies in the future. To gather the information necessary to create this initial Primer the Nuclear Maintenance Applications Center (NMAC) collected experience data from eighteen utilities plus other industry and government sources. NMAC also contacted equipment manufacturers for information pertaining to equipment utilization, maintenance, and technical specifications. The Primer includes a discussion of six methods used by analysts to study predictive maintenance data. These are: trend analysis; pattern recognition; correlation; test against limits or ranges; relative comparison data; and statistical process analysis. Following the analysis methods discussions are detailed descriptions for eighteen technologies analysts have found useful for predictive maintenance programs at power plants and other industrial facilities. Each technology subchapter has a description of the operating principles involved in the technology, a listing of plant equipment where the technology can be applied, and a general description of the monitoring equipment. Additionally, these descriptions include a discussion of results obtained from actual equipment users and preferred analysis techniques to be used on data obtained from the technology. 5 refs., 30 figs

  15. Design Creativity: Future Directions for Integrated Visualisation

    Directory of Open Access Journals (Sweden)

    Jack Steven Goulding

    2015-11-01

    Full Text Available The Architecture, Engineering and Construction (AEC sectors are facing unprecedented challenges, not just with increased complexity of projects per se, but design-related integration. This requires stakeholders to radically re-think their existing business models (and thinking that underpins them, but also the technological challenges and skills required to deliver these projects. Whilst opponents will no doubt cite that this is nothing new as the sector as a whole has always had to respond to change; the counter to this is that design ‘creativity’ is now much more dependent on integration from day one. Given this, collaborative processes embedded in Building Information Modelling (BIM models have been proffered as a panacea solution to embrace this change and deliver streamlined integration. The veracity of design teams’ “project data” is increasingly becoming paramount - not only for the coordination of design, processes, engineering services, fabrication, construction, and maintenance; but more importantly, facilitate ‘true’ project integration and interchange – the actualisation of which will require firm consensus and commitment. This Special Issue envisions some of these issues, challenges and opportunities (from a future landscape perspective, by highlighting a raft of concomitant factors, which include: technological challenges, design visualisation and integration, future digital tools, new and anticipated operating environments, and training requirements needed to deliver these aspirations. A fundamental part of this Special Issue’s ‘call’ was to capture best practice in order to demonstrate how design, visualisation and delivery processes (and technologies affect the finished product viz: design outcome, design procedures, production methodologies and construction implementation. In this respect, the use of virtual environments are now particularly effective at supporting the design and delivery processes. In

  16. High-frequency analog integrated circuit design

    CERN Document Server

    1995-01-01

    To learn more about designing analog integrated circuits (ICs) at microwave frequencies using GaAs materials, turn to this text and reference. It addresses GaAs MESFET-based IC processing. Describes the newfound ability to apply silicon analog design techniques to reliable GaAs materials and devices which, until now, was only available through technical papers scattered throughout hundred of articles in dozens of professional journals.

  17. Integrated computer aided design simulation and manufacture

    OpenAIRE

    Diko, Faek

    1989-01-01

    Computer Aided Design (CAD) and Computer Aided Manufacture (CAM) have been investigated and developed since twenty years as standalone systems. A large number of very powerful but independent packages have been developed for Computer Aided Design,Aanlysis and Manufacture. However, in most cases these packages have poor facility for communicating with other packages. Recently attempts have been made to develop integrated CAD/CAM systems and many software companies a...

  18. EZCA primer

    International Nuclear Information System (INIS)

    Karonis, N.T.

    1995-01-01

    This document provides a quick introduction to EZCA, a library that was designed to provide an easy to use interface to Channel Access (CA). As such, this document is not a user's manual, where a more detailed explanation of EZCA can be found. In short, this document is designed to get users to a state where they can be writing EZCA code as quickly as possible. It is not a document that answers all EZCA questions

  19. Integrated Energy Design of the Building Envelope

    DEFF Research Database (Denmark)

    Nielsen, Martin Vraa

    This thesis describes the outcome of the PhD project Integrated energy design of the building envelope carried out through a combination of scientific dissemination reported through peer-reviewed journals and a wide range of affiliated projects involved in at an architectural firm. The research...

  20. A new integrated microwave SQUID circuit design

    International Nuclear Information System (INIS)

    Erne, S.N.; Finnegan, T.F.

    1980-01-01

    In this paper we consider the design and operation of a planar thin-film rf-SQUID circuit which can be realized via microwave-integrated-circuit (MIC) techniques and which differs substantially from pervious microwave SQUID configurations involving either mechanical point-contact or cylindrical thin-film micro-bridge geometries. (orig.)

  1. Design Considerations for Proposed Fermilab Integrable RCS

    Energy Technology Data Exchange (ETDEWEB)

    Eldred, Jeffrey [Fermilab; Valishev, Alexander

    2017-03-02

    Integrable optics is an innovation in particle accelerator design that provides strong nonlinear focusing while avoiding parametric resonances. One promising application of integrable optics is to overcome the traditional limits on accelerator intensity imposed by betatron tune-spread and collective instabilities. The efficacy of high-intensity integrable accelerators will be undergo comprehensive testing over the next several years at the Fermilab Integrable Optics Test Accelerator (IOTA) and the University of Maryland Electron Ring (UMER). We propose an integrable Rapid-Cycling Synchrotron (iRCS) as a replacement for the Fermilab Booster to achieve multi-MW beam power for the Fermilab high-energy neutrino program. We provide a overview of the machine parameters and discuss an approach to lattice optimization. Integrable optics requires arcs with integer-pi phase advance followed by drifts with matched beta functions. We provide an example integrable lattice with features of a modern RCS - long dispersion-free drifts, low momentum compaction, superperiodicity, chromaticity correction, separate-function magnets, and bounded beta functions.

  2. Three-dimensional integrated circuit design

    CERN Document Server

    Xie, Yuan; Sapatnekar, Sachin S

    2009-01-01

    This book presents an overview of the field of 3D IC design, with an emphasis on electronic design automation (EDA) tools and algorithms that can enable the adoption of 3D ICs, and the architectural implementation and potential for future 3D system design. The aim of this book is to provide the reader with a complete understanding of: the promise of 3D ICs in building novel systems that enable the chip industry to continue along the path of performance scaling, the state of the art in fabrication technologies for 3D integration, the most prominent 3D-specific EDA challenges, along with solutio

  3. SUBSURFACE REPOSITORY INTEGRATED CONTROL SYSTEM DESIGN

    International Nuclear Information System (INIS)

    C.J. Fernado

    1998-01-01

    The purpose of this document is to develop preliminary high-level functional and physical control system architectures for the proposed subsurface repository at Yucca Mountain. This document outlines overall control system concepts that encompass and integrate the many diverse systems being considered for use within the subsurface repository. This document presents integrated design concepts for monitoring and controlling the diverse set of subsurface operations. The subsurface repository design will be composed of a series of diverse systems that will be integrated to accomplish a set of overall functions and objectives. The subsurface repository contains several Instrumentation and Control (I andC) related systems including: waste emplacement systems, ventilation systems, communication systems, radiation monitoring systems, rail transportation systems, ground control monitoring systems, utility monitoring systems (electrical, lighting, water, compressed air, etc.), fire detection and protection systems, retrieval systems, and performance confirmation systems. Each of these systems involve some level of I andC and will typically be integrated over a data communication network. The subsurface I andC systems will also integrate with multiple surface-based site-wide systems such as emergency response, health physics, security and safeguards, communications, utilities and others. The scope and primary objectives of this analysis are to: (1) Identify preliminary system level functions and interface needs (Presented in the functional diagrams in Section 7.2). (2) Examine the overall system complexity and determine how and on what levels these control systems will be controlled and integrated (Presented in Section 7.2). (3) Develop a preliminary subsurface facility-wide design for an overall control system architecture, and depict this design by a series of control system functional block diagrams (Presented in Section 7.2). (4) Develop a series of physical architectures

  4. SUBSURFACE REPOSITORY INTEGRATED CONTROL SYSTEM DESIGN

    Energy Technology Data Exchange (ETDEWEB)

    C.J. Fernado

    1998-09-17

    The purpose of this document is to develop preliminary high-level functional and physical control system architectures for the proposed subsurface repository at Yucca Mountain. This document outlines overall control system concepts that encompass and integrate the many diverse systems being considered for use within the subsurface repository. This document presents integrated design concepts for monitoring and controlling the diverse set of subsurface operations. The subsurface repository design will be composed of a series of diverse systems that will be integrated to accomplish a set of overall functions and objectives. The subsurface repository contains several Instrumentation and Control (I&C) related systems including: waste emplacement systems, ventilation systems, communication systems, radiation monitoring systems, rail transportation systems, ground control monitoring systems, utility monitoring systems (electrical, lighting, water, compressed air, etc.), fire detection and protection systems, retrieval systems, and performance confirmation systems. Each of these systems involve some level of I&C and will typically be integrated over a data communication network. The subsurface I&C systems will also integrate with multiple surface-based site-wide systems such as emergency response, health physics, security and safeguards, communications, utilities and others. The scope and primary objectives of this analysis are to: (1) Identify preliminary system level functions and interface needs (Presented in the functional diagrams in Section 7.2). (2) Examine the overall system complexity and determine how and on what levels these control systems will be controlled and integrated (Presented in Section 7.2). (3) Develop a preliminary subsurface facility-wide design for an overall control system architecture, and depict this design by a series of control system functional block diagrams (Presented in Section 7.2). (4) Develop a series of physical architectures that

  5. VGRAF primer

    Energy Technology Data Exchange (ETDEWEB)

    Padilla, G.C.; Thompson, S.L.

    1980-10-01

    VGRAF is a powerful FORTRAN program which is designed to produce professional-quality color slides, viewgraphs, posters, and data plots for presentations or reports. The program is easy to use and requires no a priori knowledge of a programming language and little or no previous programming experience. This report describes a subset of the VGRAF commands which will enable the user to make very simple plots. For enhanced plotting, the user is referred to SAND79-2147.

  6. Approaches to Integrated Building Design Environments

    DEFF Research Database (Denmark)

    Bagger-Petersen, Susanne C; Andersen, Tom

    1996-01-01

    This report discusses functional requirements and specification which needs to be defined and fulfilled to initiate development of an integrated building design environment. The purpose is to outline specifications for further discussion and development. The report documents the first phase...... in an ongoing project at the Technical University of Denmark. The overall project objective is to provide a theoretically well-founded prototype of an integrated IT-system which can serve as a device of feedback from practice and as a test-bed for the developed concept and architecture....

  7. Nuclear integrated database and design advancement system

    International Nuclear Information System (INIS)

    Ha, Jae Joo; Jeong, Kwang Sub; Kim, Seung Hwan; Choi, Sun Young.

    1997-01-01

    The objective of NuIDEAS is to computerize design processes through an integrated database by eliminating the current work style of delivering hardcopy documents and drawings. The major research contents of NuIDEAS are the advancement of design processes by computerization, the establishment of design database and 3 dimensional visualization of design data. KSNP (Korea Standard Nuclear Power Plant) is the target of legacy database and 3 dimensional model, so that can be utilized in the next plant design. In the first year, the blueprint of NuIDEAS is proposed, and its prototype is developed by applying the rapidly revolutionizing computer technology. The major results of the first year research were to establish the architecture of the integrated database ensuring data consistency, and to build design database of reactor coolant system and heavy components. Also various softwares were developed to search, share and utilize the data through networks, and the detailed 3 dimensional CAD models of nuclear fuel and heavy components were constructed, and walk-through simulation using the models are developed. This report contains the major additions and modifications to the object oriented database and associated program, using methods and Javascript.. (author). 36 refs., 1 tab., 32 figs

  8. AP1000 design and construction integration

    International Nuclear Information System (INIS)

    Winters, James W.; Clelland, Jill A.

    2004-01-01

    Construction costs of commercial nuclear generating plants must be reduced in order to expand the future use of nuclear energy. Two of the drivers of plant construction costs are the cost of financing during the construction duration and the substantial amount of skilled craft labor hours needed on site during construction. The application of information technology (IT) has been used to understand and reduce both of these drivers by establishing parallel construction paths using modules and integrating construction sequence review into the design process. In a program sponsored by EPRI, Westinghouse has modeled the construction of AP1000 in '4D' to show its viability, to improve its logic, to improve the plant design for constructibility and overall to reduce time and risk in the construction schedule. The design of most of AP1000 was constrained to be a duplicate of AP600 except where components required expansion for the higher power level. As a result, the construction schedule for AP1000 is as mature and as robust as that for AP600. Two areas important to the construction of AP1000 did require some design work because they could not remain the same as AP1000. First, the turbine building had to be redesigned to accommodate the larger turbine and its support systems. Again, as much of the AP600 design and philosophy as possible was retained. The building required enlargement and the basemat, foundations, steel structure and structural modules required modification. As concrete, steel, and equipment were defined by the designers, they were matched to the original AP600 turbine building schedule. This forced designers to assemble files to be consistent with building assembly activities and to think about constructibility as they defined the final design. Second, the reinforcement structure within the concrete under and supporting the containment vessel required detail design. Westinghouse was fortunate to have the constructor Obayashi of Japan recommend a detailed

  9. Simulation of integrated beam experiment designs

    International Nuclear Information System (INIS)

    Grote, D.P.; Sharp, W.M.

    2004-01-01

    Simulation of designs of an Integrated Beam Experiment (IBX) class accelerator have been carried out. These simulations are an important tool for validating such designs. Issues such as envelope mismatch and emittance growth can be examined in a self-consistent manner, including the details of injection, accelerator transitions, long-term transport, and longitudinal compression. The simulations are three-dimensional and time-dependent, and begin at the source. They continue up through the end of the acceleration region, at which point the data is passed on to a separate simulation of the drift compression. Results are be presented

  10. An integral design of NHR-200

    International Nuclear Information System (INIS)

    Xue Dazhi; Li Jicai; Chang Dafeng

    1997-01-01

    Nuclear heating application has received a wide attention in China due to the favourable economic and environmental aspects. The Nuclear Heating Plant NHR-200 is seen to provide the required energy for district heating, industrial processes and seawater desalination for many sites in China and possibly abroad. The paper summarizes the technical description of the plant and give its main characteristics related to the integral design approach. (author)

  11. TOWARDS TOTAL INTEGRATION IN DESIGN STUDIO

    Directory of Open Access Journals (Sweden)

    Shireesh A Deshpande

    2010-07-01

    Full Text Available Transmission of knowledge has been defined as “bringing the right knowledge by the right route at the right time to the right places.” In this context there is need to analyze the various pedagogical shifts associated with the decisive process of transmission and transaction of knowledge in design studio. Critical understanding of the importance of tangential knowledge and its integration within the design studio, leading to a comprehensive whole, is a significant aspect to be properly evolved and nourished in the studio. It can be argued that knowledge is not a substitute for architectural imagination but inadequate knowledge would handicap the general level of design. Being satisfied to manipulate formal configurations does not provide insights into the human experience. If the different types of knowledge that architecture requires are ignored, the profession will lose its credibility in the eyes of society. With the body of knowledge expanding diversely with the escalating wants of the user, and to further sustain the built environment with further progression, it’s quite certain to have an innovative design process that has a feel of antecedents yet is nourished by rationalism. Architectural Design is to an extent the yield of a creative process brought out through a refined approach, skill, and dexterity to suit the purpose. The assessors, the jury, or the teacher has created an aura of mystique around good design, without much explaining what good design is. Architectural education involves application of a theory of knowledge – what is known and how it is to be known. Nothing is taught unless it is learnt (Bono. Does the key to these issues lie in shifting from conventional mode to Total Integration Mode of Education?

  12. Integrated energy design of the building envelope

    Energy Technology Data Exchange (ETDEWEB)

    Vraa Nielsen, M.

    2012-07-01

    This thesis describes the outcome of the PhD project Integrated energy design of the building envelope carried out through a combination of scientific dissemination reported through peer-reviewed journals and a wide range of affiliated projects involved in at an architectural firm. The research project analysed how the implementation of technical knowledge early in the building design process can quantify the effect of a building's facades on its energy efficiency and indoor climate and thereby facilitate a more qualified design development. The project was structured in the following way: 1) the importance of integrating knowledge in the early stages of design, and how it can be done; 2) understanding the facade's typology; and 3) the complex notion of comfort. The project touched not only on the technical capabilities and requirements governing facade design, but also the process by which it takes place. This was done by applying the methodology of Integrated Energy Design (IED) and analysing its applicability in the design of facades. A major part of the project was an actual engagement in the architectural process to test out incorporating a consciousness about energy and comfort as part of a more holistic performance evaluation. The research project illustrates the great potential in taking passive properties into account through a geometrical optimisation inherent in the development of the architectural concept. It demonstrates that integration of technical knowledge at the early stages of design not only can qualify the geometrical processing, but also facilitate the design development of the facade. Thereby a more holistic performance optimisation can be obtained through parameters such as overall facade geometry and orientation, functional organisation, room height and depth, facade layout, window geometry and transparency, design of the window aperture, etc. Through the wide range of affiliated project involved in at the architectural firm over

  13. Integration of Airfoil Design during the design of new blades

    Energy Technology Data Exchange (ETDEWEB)

    Sartori, L.; Bottasso, L.; Croce, A. [Politecnico di Milano, Milan (Italy); Grasso, F. [ECN Wind Power, Petten (Netherlands)

    2013-09-15

    Despite the fact that the design of a new blade is a multidisciplinary task, often the different disciplines are combined together at later stage. Looking at the aerodynamic design, it is common practice design/select the airfoils first and then design the blade in terms of chord and twist based on the initial selection of the airfoils. Although this approach is quite diffused, it limits the potentialities of obtaining optimal performance. The present work is focused on investigating the benefits of designing the external shape of the blade including the airfoil shapes together with chord and twist. To accomplish this, a design approach has been developed, where an advanced gradient based optimization algorithm is able to control the shape of the blade. The airfoils described in the work are the NACA 4 digits, while the chord distribution and the twist distribution are described through Bezier curves. In this way, the complexity of the problem is limited while a versatile geometrical description is kept. After the details of the optimization scheme are illustrated, several numerical examples are shown, demonstrating the advantages in terms of performance and development time of integrating the design of the airfoils during the optimization of the blade.

  14. Conservative fragments in bacterial 16S rRNA genes and primer design for 16S ribosomal DNA amplicons in metagenomic studies

    KAUST Repository

    Wang, Yong

    2009-10-09

    Bacterial 16S ribosomal DNA (rDNA) amplicons have been widely used in the classification of uncultured bacteria inhabiting environmental niches. Primers targeting conservative regions of the rDNAs are used to generate amplicons of variant regions that are informative in taxonomic assignment. One problem is that the percentage coverage and application scope of the primers used in previous studies are largely unknown. In this study, conservative fragments of available rDNA sequences were first mined and then used to search for candidate primers within the fragments by measuring the coverage rate defined as the percentage of bacterial sequences containing the target. Thirty predicted primers with a high coverage rate (>90%) were identified, which were basically located in the same conservative regions as known primers in previous reports, whereas 30% of the known primers were associated with a coverage rate of <90%. The application scope of the primers was also examined by calculating the percentages of failed detections in bacterial phyla. Primers A519-539, E969- 983, E1063-1081, U515 and E517, are highly recommended because of their high coverage in almost all phyla. As expected, the three predominant phyla, Firmicutes, Gemmatimonadetes and Proteobacteria, are best covered by the predicted primers. The primers recommended in this report shall facilitate a comprehensive and reliable survey of bacterial diversity in metagenomic studies. © 2009 Wang, Qian.

  15. Design of integral magnetic field sensor

    International Nuclear Information System (INIS)

    Ma Liang; Cheng Yinhui; Wu Wei; Li Baozhong; Zhou Hui; Li Jinxi; Zhu Meng

    2010-01-01

    Magnetic field is one of the important physical parameters in the measuring process of pulsed EMP. We researched on anti-interference and high-sensitivity measurement technique of magnetic field in this report. Semi rigid cables were to bent into ringed antenna so that the antenna was shielded from electric-field interference and had little inductance; In order to have high sensitivity, operational transconductance amplifier was used to produce an active integrator; We designed an optical-electronic transferring module to upgrade anti-interference capability of the magnetic-field measurement system. A measurement system of magnetic field was accomplished. The measurement system was composed of antenna, integrator, and optical-electric transferring module and so on. We calibrated the measurement system in coaxial TEM cell. It indicates that, the measurement system's respondence of rise time is up to 2.5 ns, and output width at 90%-maximum of the pulse is wider than 200 ns. (authors)

  16. A Hearing Aid Primer 1

    Science.gov (United States)

    Yetter, Carol J.

    2009-01-01

    This hearing aid primer is designed to define the differences among the three levels of hearing instrument technology: conventional analog circuit technology (most basic), digitally programmable/analog circuit technology (moderately advanced), and fully digital technology (most advanced). Both moderate and advanced technologies mean that hearing…

  17. Conceptual design of inherently safe integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J. I.; Chang, M. H.; Lee, D. J. and others

    1999-03-01

    The design concept of a 300 MWt inherently safe integral reactor(ISIR) for the propulsion of extra large and superhigh speed container ship was developed in this report. The scope and contents of this report are as follows : 1. The state of the art of the technology for ship-mounted reactor 2. Design requirements for ISIR 3. Fuel and core design 4. Conceptual design of fluid system 5. Conceptual design of reactor vessel assembly and primary components 6. Performance analyses and safety analyses. Installation of two ISIRs with total thermal power of 600MWt and efficiency of 21% is capable of generating shaft power of 126,000kW which is sufficient to power a container ship of 8,000TEU with 30knot cruise speed. Larger and speedier ship can be considered by installing 4 ISIRs. Even though the ISIR was developed for ship propulsion, it can be used also for a multi-purpose nuclear power plant for electricity generation, local heating, or seawater desalination by mounting on a movable floating barge. (author)

  18. Integrated design of the SSC linac injector

    International Nuclear Information System (INIS)

    Evans, D.; Valiecnti, R.; Wood, F.

    1992-01-01

    The Ion Source, Low Energy Beam Transport (LEBT), and Radio Frequency Quadrupole (RFQ) of the Superconducting Super Collider (SSC) Linac act as a unit (referred to as the Linac Injector), the Ion Source and LEBT being cantilevered off of the RFQ. Immediately adjacent to both ends of the RFQ cavity proper are endwall chambers containing beam instrumentation and independently-operated vacuum isolation valves. The Linac Injector delivers 30 mA of H - beam at 2.5 MeV. This paper describes the design constraints imposed on the endwalls, aspects of the integration of the Ion Source and LEBT including attachment to the RFQ, maintainability and interchangeability of LEBTs, vacuum systems for each component, and the design of necessary support structure. (Author) 2 tab

  19. Integrated safeguards and facility design and operations

    International Nuclear Information System (INIS)

    Tape, J.W.; Coulter, C.A.; Markin, J.T.; Thomas, K.E.

    1987-01-01

    The integration of safeguards functions to deter or detect unauthorized actions by an insider requires the careful communication and management of safeguards-relevant information on a timely basis. The traditional separation of safeguards functions into physical protection, materials control, and materials accounting often inhibits important information flows. Redefining the major safeguards functions as authorization, enforcement, and verification, and careful attention to management of information from acquisition to organization, to analysis, to decision making can result in effective safeguards integration. The careful inclusion of these ideas in facility designs and operations will lead to cost-effective safeguards systems. The safeguards authorization function defines, for example, personnel access requirements, processing activities, and materials movements/locations that are permitted to accomplish the mission of the facility. Minimizing the number of authorized personnel, limiting the processing flexibility, and maintaining up-to-date flow sheets will facilitate the detection of unauthorized activities. Enforcement of the authorized activities can be achieved in part through the use of barriers, access control systems, process sensors, and health and safety information. Consideration of safeguards requirements during facility design can improve the enforcement function. Verification includes the familiar materials accounting activities as well as auditing and testing of the other functions

  20. Designing TSVs for 3D Integrated Circuits

    CERN Document Server

    Khan, Nauman

    2013-01-01

    This book explores the challenges and presents best strategies for designing Through-Silicon Vias (TSVs) for 3D integrated circuits.  It describes a novel technique to mitigate TSV-induced noise, the GND Plug, which is superior to others adapted from 2-D planar technologies, such as a backside ground plane and traditional substrate contacts. The book also investigates, in the form of a comparative study, the impact of TSV size and granularity, spacing of C4 connectors, off-chip power delivery network, shared and dedicated TSVs, and coaxial TSVs on the quality of power delivery in 3-D ICs. The authors provide detailed best design practices for designing 3-D power delivery networks.  Since TSVs occupy silicon real-estate and impact device density, this book provides four iterative algorithms to minimize the number of TSVs in a power delivery network. Unlike other existing methods, these algorithms can be applied in early design stages when only functional block- level behaviors and a floorplan are available....

  1. Applied Integrated Design in Composite UAV Development

    Science.gov (United States)

    Vasić, Zoran; Maksimović, Stevan; Georgijević, Dragutin

    2018-04-01

    This paper presents a modern approach to integrated development of Unmanned Aerial Vehicle made of laminated composite materials from conceptual design, through detail design, strength and stiffness analyses, definition and management of design and production data, detailed tests results and other activities related to development of laminated composite structures with main of its particularities in comparison to metal structures. Special attention in this work is focused to management processes of product data during life cycle of an UAV and experimental tests of its composite wing. Experience shows that the automation management processes of product data during life cycle, as well as processes of manufacturing, are inevitable if a company wants to get cheaper and quality composite aircraft structures. One of the most effective ways of successful management of product data today is Product Life cycle Management (PLM). In terms of the PLM, a spectrum of special measures and provisions has to be implemented when defining fiber-reinforced composite material structures in comparison to designing with metals which is elaborated in the paper.

  2. Integrated computer-aided design using minicomputers

    Science.gov (United States)

    Storaasli, O. O.

    1980-01-01

    Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM), a highly interactive software, has been implemented on minicomputers at the NASA Langley Research Center. CAD/CAM software integrates many formerly fragmented programs and procedures into one cohesive system; it also includes finite element modeling and analysis, and has been interfaced via a computer network to a relational data base management system and offline plotting devices on mainframe computers. The CAD/CAM software system requires interactive graphics terminals operating at a minimum of 4800 bits/sec transfer rate to a computer. The system is portable and introduces 'interactive graphics', which permits the creation and modification of models interactively. The CAD/CAM system has already produced designs for a large area space platform, a national transonic facility fan blade, and a laminar flow control wind tunnel model. Besides the design/drafting element analysis capability, CAD/CAM provides options to produce an automatic program tooling code to drive a numerically controlled (N/C) machine. Reductions in time for design, engineering, drawing, finite element modeling, and N/C machining will benefit productivity through reduced costs, fewer errors, and a wider range of configuration.

  3. Primers-4-Yeast: a comprehensive web tool for planning primers for Saccharomyces cerevisiae.

    Science.gov (United States)

    Yofe, Ido; Schuldiner, Maya

    2014-02-01

    The budding yeast Saccharomyces cerevisiae is a key model organism of functional genomics, due to its ease and speed of genetic manipulations. In fact, in this yeast, the requirement for homologous sequences for recombination purposes is so small that 40 base pairs (bp) are sufficient. Hence, an enormous variety of genetic manipulations can be performed by simply planning primers with the correct homology, using a defined set of transformation plasmids. Although designing primers for yeast transformations and for the verification of their correct insertion is a common task in all yeast laboratories, primer planning is usually done manually and a tool that would enable easy, automated primer planning for the yeast research community is still lacking. Here we introduce Primers-4-Yeast, a web tool that allows primers to be designed in batches for S. cerevisiae gene-targeting transformations, and for the validation of correct insertions. This novel tool enables fast, automated, accurate primer planning for large sets of genes, introduces consistency in primer planning and is therefore suggested to serve as a standard in yeast research. Primers-4-Yeast is available at: http://www.weizmann.ac.il/Primers-4-Yeast Copyright © 2013 John Wiley & Sons, Ltd.

  4. Integrating conceptualizations of experience into the interaction design process

    DEFF Research Database (Denmark)

    Dalsgaard, Peter

    2010-01-01

    From a design perspective, the increasing awareness of experiential aspects of interactive systems prompts the question of how conceptualizations of experience can inform and potentially be integrated into the interaction design process. This paper presents one approach to integrating theoretical...

  5. Integrated design of SIGMA uranium enrichment plants

    International Nuclear Information System (INIS)

    Rivarola, Martin E.; Brasnarof, Daniel O.

    1999-01-01

    In the present work, we describe a preliminary analysis of the design feedbacks in a Uranium Enrichment Plant, using the SIGMA concept. Starting from the result of this analysis, a computer code has been generated, which allows finding the optimal configurations of plants, for a fixed production rate. The computer code developed includes the model of the Thermohydraulic loop of a SIGMA module. The model contains numerical calculations of the main components of the circuit. During the calculations, the main components are dimensioned, for a posterior cost compute. The program also makes an estimation of the enrichment gain of the porous membrane, for each separation stage. Once the dimensions of the main components are known, using the enrichment cascade calculation, the capital and operation costs of the plant could be determined. At this point it is simple to calculate a leveled cost of the Separative Work Unit (SWU). A numerical optimizer is also included in the program. This optimizer finds the optimal cascade configuration, for a given set of design parameters. The whole-integrated program permits to investigate in detail the feedback in the component design. Therefore, the sensibility of the more relevant parameters can be computed, with respect of the economical variables of the plant. (author)

  6. Polyacid macromolecule primers

    Science.gov (United States)

    Sugama, Toshifumi.

    1989-12-26

    Hydrophilic polyacids are described, such as macromolecules of polyitaconic acid and polyacrylic acid, where such macromolecules have molecular weights >50,000 as primers between a polymeric top coating, such as polyurethane, and an oxidized aluminum or aluminum alloy. A near monolayer of primer is used in polymeric adhesive/oxidized aluminum adhered joint systems in 0.05% primer concentration to give superior results in standard peel tests. 2 figs.

  7. Design of primers for pertussis diagnosis by Real Time PCR and determination of its sensitivity and specificity in comparison with commercial kits.

    Directory of Open Access Journals (Sweden)

    Hamidreza Monavari

    2013-12-01

    Results: Performance of our home made primers for detecting pertussis using Real Time PCR in comparison with those by commercial kit was acceptable based on diagnostic classical guidance (WHO and the (CDC. Conclusions: Real time PCR test with new primers in comparison with culture techniques is more suitable, high sensitivity and can provide more informative values for pertussis detection.

  8. Toward integrated design of waste management technologies

    International Nuclear Information System (INIS)

    Carnes, S.A.; Wolfe, A.K.

    1994-01-01

    Implementation of waste management technologies has been hindered by the intervention of diverse interests. Relying on a perceived history of inadequate and improper management, operations, and technological design, critics have stymied the implementation of scientifically and governmentally approved technologies and facilities, leading to a critical shortage of hazardous, mixed, and radioactive waste management capacity. The research and development (R ampersand D) required to identify technologies that are simultaneously (1) scientifically valid, (2) economically sound, and (3) publicly acceptable must necessarily address, in an integrated and interdisciplinary manner, these three criteria and how best to achieve the integration of stakeholders early in the technology implementation process (i.e., R ampersand D, demonstration, and commercialization). The goal of this paper is to initiate an identification of factors likely to render radioactive and hazardous waste management technologies publicly acceptable and to provide guidance on how technological R ampersand D might be revised to enhance the acceptability of alternative waste management technologies. Principal among these factors are the equitable distribution of costs, risks, and benefits of waste management policies and technologies, the equitable distribution of authority for making waste management policy and selecting technologies for implementation, and the equitable distribution of responsibility for resolving waste management problems. Stakeholder participation in assessing the likely distribution of these factors and mitigative mechanisms to enhance their equitable distribution, together with stakeholder participation in policy and technology R ampersand D, as informed by stakeholder assessments, should enhance the identification of acceptable policies and technologies

  9. DEMO port plug design and integration studies

    Science.gov (United States)

    Grossetti, G.; Boccaccini, L. V.; Cismondi, F.; Del Nevo, A.; Fischer, U.; Franke, T.; Granucci, G.; Hernández, F.; Mozzillo, R.; Strauß, D.; Tran, M. Q.; Vaccaro, A.; Villari, R.

    2017-11-01

    The EUROfusion Consortium established in 2014 and composed by European Fusion Laboratories, and in particular the Power Plant Physics and Technology department aims to develop a conceptual design for the Fusion DEMOnstration Power Plant, DEMO. With respect to present experimental machines and ITER, the main goals of DEMO are to produce electricity continuously for a period of about 2 h, with a net electrical power output of a few hundreds of MW, and to allow tritium self-sufficient breeding with an adequately high margin in order to guarantee its planned operational schedule, including all planned maintenance intervals. This will eliminate the need to import tritium fuel from external sources during operations. In order to achieve these goals, extensive engineering efforts as well as physics studies are required to develop a design that can ensure a high level of plant reliability and availability. In particular, interfaces between systems must be addressed at a very early phase of the project, in order to proceed consistently. In this paper we present a preliminary design and integration study, based on physics assessments for the EU DEMO1 Baseline 2015 with an aspect ratio of 3.1 and 18 toroidal field coils, for the DEMO port plugs. These aim to host systems like electron cyclotron heating launchers currently developed within the Work Package Heating and Current Drive that need an external radial access to the plasma and through in-vessel systems like the breeder blanket. A similar approach shown here could be in principle followed by other systems, e.g. other heating and current drive systems or diagnostics. The work addresses the interfaces between the port plug and the blanket considering the helium-cooled pebble bed and the water cooled lithium lead which are two of four breeding blanket concepts under investigation in Europe within the Power Plant Physics and Technology Programme: the required openings will be evaluated in terms of their impact onto the

  10. Architectures for Green-Field Supply Chain Integration: Supply Chain Integration Design

    OpenAIRE

    Radanliev, Petar

    2015-01-01

    This paper applied case study research to design architectures for green-field supply chain integration. The integration design is based on a case study of a supply chain integration of 5 companies, operating in different, but supply chain complimenting industry sectors. The case study research is applied to design and validate the architectures in a real world scenario. The supply\\ud chain integration architectures enable the conversion of individual into integrated strategies. The architect...

  11. Design integration of liquid surface divertors

    International Nuclear Information System (INIS)

    Nygren, R.E.; Cowgill, D.F.; Ulrickson, M.A.; Nelson, B.E.; Fogarty, P.J.; Rognlien, T.D.; Rensink, M.E.; Hassanein, A.; Smolentsev, S.S.; Kotschenreuther, M.

    2004-01-01

    The US Enabling Technology Program in fusion is investigating the use of free flowing liquid surfaces facing the plasma. We have been studying the issues in integrating a liquid surface divertor into a configuration based upon an advanced tokamak, specifically the ARIES-RS configuration. The simplest form of such a divertor is to extend the flow of the liquid first wall into the divertor and thereby avoid introducing additional fluid streams. In this case, one can modify the flow above the divertor to enhance thermal mixing. For divertors with flowing liquid metals (or other electrically conductive fluids) MHD (magneto-hydrodynamics) effects are a major concern and can produce forces that redirect flow and suppress turbulence. An evaluation of Flibe (a molten salt) as a working fluid was done to assess a case in which the MHD forces could be largely neglected. Initial studies indicate that, for a tokamak with high power density, an integrated Flibe first wall and divertor does not seem workable. We have continued work with molten salts and replaced Flibe with Flinabe, a mixture of lithium, sodium and beryllium fluorides, that has some potential because of its lower melting temperature. Sn and Sn-Li have also been considered, and the initial evaluations on heat removal with minimal plasma contamination show promise, although the complicated 3D MHD flows cannot yet be fully modeled. Particle pumping in these design concepts is accomplished by conventional means (ports and pumps). However, trapping of hydrogen in these flowing liquids seems plausible and novel concepts for entrapping helium are also being studied

  12. A versatile method to design stem-loop primer-based quantitative PCR assays for detecting small regulatory RNA molecules.

    Directory of Open Access Journals (Sweden)

    Zsolt Czimmerer

    Full Text Available Short regulatory RNA-s have been identified as key regulators of gene expression in eukaryotes. They have been involved in the regulation of both physiological and pathological processes such as embryonal development, immunoregulation and cancer. One of their relevant characteristics is their high stability, which makes them excellent candidates for use as biomarkers. Their number is constantly increasing as next generation sequencing methods reveal more and more details of their synthesis. These novel findings aim for new detection methods for the individual short regulatory RNA-s in order to be able to confirm the primary data and characterize newly identified subtypes in different biological conditions. We have developed a flexible method to design RT-qPCR assays that are very sensitive and robust. The newly designed assays were tested extensively in samples from plant, mouse and even human formalin fixed paraffin embedded tissues. Moreover, we have shown that these assays are able to quantify endogenously generated shRNA molecules. The assay design method is freely available for anyone who wishes to use a robust and flexible system for the quantitative analysis of matured regulatory RNA-s.

  13. A one-step reaction for the rapid identification of Lactobacillus mindensis, Lactobacillus panis, Lactobacillus paralimentarius, Lactobacillus pontis and Lactobacillus frumenti using oligonucleotide primers designed from the 16S-23S rRNA intergenic sequences.

    Science.gov (United States)

    Ferchichi, M; Valcheva, R; Prévost, H; Onno, B; Dousset, X

    2008-06-01

    Species-specific primers targeting the 16S-23S ribosomal DNA (rDNA) intergenic spacer region (ISR) were designed to rapidly discriminate between Lactobacillus mindensis, Lactobacillus panis, Lactobacillus paralimentarius, Lactobacillus pontis and Lactobacillus frumenti species recently isolated from French sourdough. The 16S-23S ISRs were amplified using primers 16S/p2 and 23S/p7, which anneal to positions 1388-1406 of the 16S rRNA gene and to positions 207-189 of the 23S rRNA gene respectively, Escherichia coli numbering (GenBank accession number V00331). Clone libraries of the resulting amplicons were constructed using a pCR2.1 TA cloning kit and sequenced. Species-specific primers were designed based on the sequences obtained and were used to amplify the 16S-23S ISR in the Lactobacillus species considered. For all of them, two PCR amplicons, designated as small ISR (S-ISR) and large ISR (L-ISR), were obtained. The L-ISR is composed of the corresponding S-ISR, interrupted by a sequence containing tRNA(Ile) and tRNA(Ala) genes. Based on these sequences, species-specific primers were designed and proved to identify accurately the species considered among 30 reference Lactobacillus species tested. Designed species-specific primers enable a rapid and accurate identification of L. mindensis, L. paralimentarius, L. panis, L. pontis and L. frumenti species among other lactobacilli. The proposed method provides a powerful and convenient means of rapidly identifying some sourdough lactobacilli, which could be of help in large starter culture surveys.

  14. Ground Vehicle System Integration (GVSI) and Design Optimization Model

    National Research Council Canada - National Science Library

    Horton, William

    1996-01-01

    This report documents the Ground Vehicle System Integration (GVSI) and Design Optimization Model GVSI is a top-level analysis tool designed to support engineering tradeoff studies and vehicle design optimization efforts...

  15. Integration of design applications with building models

    DEFF Research Database (Denmark)

    Eastman, C. M.; Jeng, T. S.; Chowdbury, R.

    1997-01-01

    This paper reviews various issues in the integration of applications with a building model... (Truncated.)......This paper reviews various issues in the integration of applications with a building model... (Truncated.)...

  16. Analysis and meta-analysis of single-case designs with a standardized mean difference statistic: a primer and applications.

    Science.gov (United States)

    Shadish, William R; Hedges, Larry V; Pustejovsky, James E

    2014-04-01

    This article presents a d-statistic for single-case designs that is in the same metric as the d-statistic used in between-subjects designs such as randomized experiments and offers some reasons why such a statistic would be useful in SCD research. The d has a formal statistical development, is accompanied by appropriate power analyses, and can be estimated using user-friendly SPSS macros. We discuss both advantages and disadvantages of d compared to other approaches such as previous d-statistics, overlap statistics, and multilevel modeling. It requires at least three cases for computation and assumes normally distributed outcomes and stationarity, assumptions that are discussed in some detail. We also show how to test these assumptions. The core of the article then demonstrates in depth how to compute d for one study, including estimation of the autocorrelation and the ratio of between case variance to total variance (between case plus within case variance), how to compute power using a macro, and how to use the d to conduct a meta-analysis of studies using single-case designs in the free program R, including syntax in an appendix. This syntax includes how to read data, compute fixed and random effect average effect sizes, prepare a forest plot and a cumulative meta-analysis, estimate various influence statistics to identify studies contributing to heterogeneity and effect size, and do various kinds of publication bias analyses. This d may prove useful for both the analysis and meta-analysis of data from SCDs. Copyright © 2013 Society for the Study of School Psychology. Published by Elsevier Ltd. All rights reserved.

  17. Designing interaction behaviour in service-oriented enterprise application integration

    NARCIS (Netherlands)

    Dirgahayu, T.; Quartel, Dick; van Sinderen, Marten J.

    In this paper we present an approach for designing interaction behaviour in service-oriented enterprise application integration. The approach enables business analysts to actively participate in the design of an integration solution. In this way, we expect that the solution meets its integration

  18. Integral Design methodology for Industrial Collaboration Design of Sustainable Industrial Flexible Demountable buildings

    NARCIS (Netherlands)

    Zeiler, W.; Quanjel, E.M.C.J.; Bauer, M.; Lima, C.

    2007-01-01

    Starting in 1998 from developing and designing their own office Kropman, a major Dutch Building Services contractor, developed a new methodology for structuring and documenting integral design processes. Integral design is meant to integrate the different disciplines involved in the building design

  19. Integrated network design and scheduling problems :

    Energy Technology Data Exchange (ETDEWEB)

    Nurre, Sarah G.; Carlson, Jeffrey J.

    2014-01-01

    We consider the class of integrated network design and scheduling problems. These problems focus on selecting and scheduling operations that will change the characteristics of a network, while being speci cally concerned with the performance of the network over time. Motivating applications of INDS problems include infrastructure restoration after extreme events and building humanitarian distribution supply chains. While similar models have been proposed, no one has performed an extensive review of INDS problems from their complexity, network and scheduling characteristics, information, and solution methods. We examine INDS problems under a parallel identical machine scheduling environment where the performance of the network is evaluated by solving classic network optimization problems. We classify that all considered INDS problems as NP-Hard and propose a novel heuristic dispatching rule algorithm that selects and schedules sets of arcs based on their interactions in the network. We present computational analysis based on realistic data sets representing the infrastructures of coastal New Hanover County, North Carolina, lower Manhattan, New York, and a realistic arti cial community CLARC County. These tests demonstrate the importance of a dispatching rule to arrive at near-optimal solutions during real-time decision making activities. We extend INDS problems to incorporate release dates which represent the earliest an operation can be performed and exible release dates through the introduction of specialized machine(s) that can perform work to move the release date earlier in time. An online optimization setting is explored where the release date of a component is not known.

  20. Flexible heat pipes with integrated bioinspired design

    Directory of Open Access Journals (Sweden)

    Chao Yang

    2015-02-01

    Full Text Available In this work we report the facile fabrication and performance evaluation of flexible heat pipes that have integrated bioinspired wick structures and flexible polyurethane polymer connector design between the copper condenser and evaporator. Inside the heat pipe, a bioinspired superhydrophilic strong-base-oxidized copper mesh with multi-scale micro/nano-structures was used as the wicking material and deionized water was selected as working fluid. Thermal resistances of the fabricated flexible heat pipes charged with different filling ratios were measured under thermal power inputs ranging from 2 W to 12 W while the device was bent at different angles. The fabricated heat pipes with a 30% filling ratio demonstrated a low thermal resistance less than 0.01 K/W. Compared with the vertically oriented straight heat pipes, bending from 30° up to 120° has negligible influence on the heat-transfer performance. Furthermore, repeated heating tests indicated that the fabricated flexible heat pipes have consistent and reliable heat-transfer performance, thus would have important applications for advanced thermal management in three dimensional and flexible electronic devices.

  1. Conservative fragments in bacterial 16S rRNA genes and primer design for 16S ribosomal DNA amplicons in metagenomic studies

    KAUST Repository

    Wang, Yong; Qian, Pei-Yuan

    2009-01-01

    Bacterial 16S ribosomal DNA (rDNA) amplicons have been widely used in the classification of uncultured bacteria inhabiting environmental niches. Primers targeting conservative regions of the rDNAs are used to generate amplicons of variant regions

  2. Bayesian methodology for the design and interpretation of clinical trials in critical care medicine: a primer for clinicians.

    Science.gov (United States)

    Kalil, Andre C; Sun, Junfeng

    2014-10-01

    To review Bayesian methodology and its utility to clinical decision making and research in the critical care field. Clinical, epidemiological, and biostatistical studies on Bayesian methods in PubMed and Embase from their inception to December 2013. Bayesian methods have been extensively used by a wide range of scientific fields, including astronomy, engineering, chemistry, genetics, physics, geology, paleontology, climatology, cryptography, linguistics, ecology, and computational sciences. The application of medical knowledge in clinical research is analogous to the application of medical knowledge in clinical practice. Bedside physicians have to make most diagnostic and treatment decisions on critically ill patients every day without clear-cut evidence-based medicine (more subjective than objective evidence). Similarly, clinical researchers have to make most decisions about trial design with limited available data. Bayesian methodology allows both subjective and objective aspects of knowledge to be formally measured and transparently incorporated into the design, execution, and interpretation of clinical trials. In addition, various degrees of knowledge and several hypotheses can be tested at the same time in a single clinical trial without the risk of multiplicity. Notably, the Bayesian technology is naturally suited for the interpretation of clinical trial findings for the individualized care of critically ill patients and for the optimization of public health policies. We propose that the application of the versatile Bayesian methodology in conjunction with the conventional statistical methods is not only ripe for actual use in critical care clinical research but it is also a necessary step to maximize the performance of clinical trials and its translation to the practice of critical care medicine.

  3. Integral Design workshops: organization, structure and testing

    OpenAIRE

    Zeiler, W Wim; Savanovic, P Perica

    2010-01-01

    The purpose of this paper is to achieve an understanding of design activities in the context of building design. The starting point is an overview of design research and design methodology. From the insights gained by this analysis of design in this specific context, we present an 'organization structure and design' workshop approach for collaborative multi-discipline design management. The workshops set-up, used to implement and to test the approach, are presented as well as the experiences ...

  4. High occurrence of Bathyarchaeota (MCG) in the deep-sea sediments of South China Sea quantified using newly designed PCR primers.

    Science.gov (United States)

    Yu, Tiantian; Liang, Qianyong; Niu, Mingyang; Wang, Fengping

    2017-08-01

    The archaeal phylum Bathyarchaeota, which is composed of a large number of diverse lineages, is widespread and abundant in marine sediments. Environmental factors that control the distribution, abundance and evolution of this largely diversified archaeal phylum are currently unclear. In this study, a new pair of specific primers that target the major marine subgroups of bathyarchaeotal 16S rRNA genes was designed and evaluated to investigate the distribution and abundance of Bathyarchaeota in marine sediments. The abundance of Bathyarchaeota along two sediment cores from the deep-sea sediments of South China Sea (SCS, each from the Dongsha and Shenhu area) was determined. A strong correlation was found between the bathyarchaeotal abundance and the content of total organic carbon (TOC), suggesting an important role of Bathyarchaeota in organic matter remineralisation in the sediments of SCS. Furthermore, diversity analysis revealed that subgroups Bathy-2, Bathy-8 and Bathy-10 were dominant bathyarchaeotal members of the deep-sea sediments in the SCS. Bathy-8 was found predominantly within the reducing and deeper sediment layers, while Bathy-10 occurred preferentially in the oxidizing and shallower sediment layers. Our study lays a foundation for the further understanding of the ecological functions and niche differentiation of the important but not well-understood sedimentary archaeal group. © 2017 Society for Applied Microbiology and John Wiley & Sons Ltd.

  5. Integral Design workshops: organization, structure and testing

    NARCIS (Netherlands)

    Zeiler, W.; Savanovic, P.

    2010-01-01

    The purpose of this paper is to achieve an understanding of design activities in the context of building design. The starting point is an overview of design research and design methodology. From the insights gained by this analysis of design in this specific context, we present an ‘organization

  6. Designing Integrated Product- Service System Solutions in Manufacturing Industries

    DEFF Research Database (Denmark)

    Costa, Nina; Patrício, Lia; Morelli, Nicola

    2015-01-01

    Manufacturing firms are increasingly evolving towards the design of integrated product-service solutions but servitization literature does not provide specific guidance on how to design these integrated solutions. Building upon ProductService System (PSS) and Service Design (SD) approaches...... how it brings new insights to manufacturing companies moving to a service, value cocreation perspective....

  7. Building Integrated Design Practice under the Concept of Sustainable Development

    Science.gov (United States)

    Liu, Xuexin

    2018-03-01

    With the continuous development of social economy, people are more demanding for architecture. Some advanced design concepts are gradually applied to the design of buildings. Under the concept of sustainable development, building integration design has also been widely used to promote the rapid development of architectural design. Integrated design concepts and sustainable development concepts play an important role to meet people’s requirements. This article will explore the concept of sustainable development under the concept of integrated architectural design and practice analysis, propose appropriate measures.

  8. Quick spacecraft charging primer

    International Nuclear Information System (INIS)

    Larsen, Brian Arthur

    2014-01-01

    This is a presentation in PDF format which is a quick spacecraft charging primer, meant to be used for program training. It goes into detail about charging physics, RBSP examples, and how to identify charging.

  9. Integrated Intelligent Modeling, Design and Control of Crystal Growth Processes

    National Research Council Canada - National Science Library

    Prasad, V

    2000-01-01

    .... This MURI program took an integrated approach towards modeling, design and control of crystal growth processes and in conjunction with growth and characterization experiments developed much better...

  10. Strategic Mobility 21: Integrated Tracking System Analysis and Concept Design

    National Research Council Canada - National Science Library

    Mallon, Lawrence G; Savacool, Edwin

    2007-01-01

    ... (ITS). This ITS design document identifies the technical and functional requirements for developing, procuring, and integrating components of an ITS capable of supporting an inland regional port, multi...

  11. Nanotechnology: A Policy Primer

    Science.gov (United States)

    2013-06-24

    savings in the United States of 24 million barrels of oil.4 • Universal access to clean water. Nanotechnology water desalination and filtration...CRS Report for Congress Prepared for Members and Committees of Congress Nanotechnology : A Policy Primer John F. Sargent Jr. Specialist...COVERED 00-00-2013 to 00-00-2013 4. TITLE AND SUBTITLE Nanotechnology : A Policy Primer 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT

  12. Primer to Design Safe School Projects in Case of Terrorist Attacks and School Shootings. Buildings and Infrastructure Protection Series. FEMA-428/BIPS-07/January 2012. Edition 2

    Science.gov (United States)

    Chipley, Michael; Lyon, Wesley; Smilowitz, Robert; Williams, Pax; Arnold, Christopher; Blewett, William; Hazen, Lee; Krimgold, Fred

    2012-01-01

    This publication, part of the new Building and Infrastructure Protection Series (BIPS) published by the Department of Homeland Security (DHS) Science and Technology Directorate (S&T) Infrastructure Protection and Disaster Management Division (IDD), serves to advance high performance and integrated design for buildings and infrastructure. This…

  13. Hermeneutics framework: integration of design rationale and optimizing software modules

    NARCIS (Netherlands)

    Aksit, Mehmet; Malakuti Khah Olun Abadi, Somayeh

    To tackle the evolution challenges of adaptive systems, this paper argues on the necessity of hermeneutic approaches that help to avoid too early elimination of design alternatives. This visionary paper proposes the Hermeneutics Framework, which computationally integrates a design rationale

  14. Process Variations and Probabilistic Integrated Circuit Design

    CERN Document Server

    Haase, Joachim

    2012-01-01

    Uncertainty in key parameters within a chip and between different chips in the deep sub micron era plays a more and more important role. As a result, manufacturing process spreads need to be considered during the design process.  Quantitative methodology is needed to ensure faultless functionality, despite existing process variations within given bounds, during product development.   This book presents the technological, physical, and mathematical fundamentals for a design paradigm shift, from a deterministic process to a probability-orientated design process for microelectronic circuits.  Readers will learn to evaluate the different sources of variations in the design flow in order to establish different design variants, while applying appropriate methods and tools to evaluate and optimize their design.  Trains IC designers to recognize problems caused by parameter variations during manufacturing and to choose the best methods available to mitigate these issues during the design process; Offers both qual...

  15. Collaborative integral design of active roofs

    NARCIS (Netherlands)

    Zeiler, W.; Quanjel, E.M.C.J.; Borsboom, W.A.

    2009-01-01

    The application of photo-voltaic elements is the most economical on the roof. Still this often leads to severe problems due to poor coordination of all the design and practical aspects involved. This paper describes the research methodology, based on Methodical Design, as used in a design approach

  16. Global design of an active integrated antenna for millimeter wave

    OpenAIRE

    Marzolf, Eric; Drissi, M’hamed

    2001-01-01

    An active integrated antenna working in the millimeter wave has been realized in a monolithic process. The concept of active integrated antenna is first introduced, then the design of the integrated circuit based on a global approach, following electromagnetic and circuit simulations, is presented. The obtained performances of the active antenna are discussed and compared to a passive one.

  17. Multiplexing Short Primers for Viral Family PCR

    Energy Technology Data Exchange (ETDEWEB)

    Gardner, S N; Hiddessen, A L; Hara, C A; Williams, P L; Wagner, M; Colston, B W

    2008-06-26

    We describe a Multiplex Primer Prediction (MPP) algorithm to build multiplex compatible primer sets for large, diverse, and unalignable sets of target sequences. The MPP algorithm is scalable to larger target sets than other available software, and it does not require a multiple sequence alignment. We applied it to questions in viral detection, and demonstrated that there are no universally conserved priming sequences among viruses and that it could require an unfeasibly large number of primers ({approx}3700 18-mers or {approx}2000 10-mers) to generate amplicons from all sequenced viruses. We then designed primer sets separately for each viral family, and for several diverse species such as foot-and-mouth disease virus, hemagglutinin and neuraminidase segments of influenza A virus, Norwalk virus, and HIV-1.

  18. Design of 3D integrated circuits and systems

    CERN Document Server

    Sharma, Rohit

    2014-01-01

    Three-dimensional (3D) integration of microsystems and subsystems has become essential to the future of semiconductor technology development. 3D integration requires a greater understanding of several interconnected systems stacked over each other. While this vertical growth profoundly increases the system functionality, it also exponentially increases the design complexity. Design of 3D Integrated Circuits and Systems tackles all aspects of 3D integration, including 3D circuit and system design, new processes and simulation techniques, alternative communication schemes for 3D circuits and sys

  19. Advanced Concept Architecture Design and Integrated Analysis (ACADIA)

    Science.gov (United States)

    2017-11-03

    1 Advanced Concept Architecture Design and Integrated Analysis (ACADIA) Submitted to the National Institute of Aerospace (NIA) on...Research Report 20161001 - 20161030 Advanced Concept Architecture Design and Integrated Analysis (ACADIA) W911NF-16-2-0229 8504Cedric Justin, Youngjun

  20. The Exploration of Green Architecture Design Integration Teaching Mode

    Science.gov (United States)

    Shuang, Liang; Yibin, Han

    2016-01-01

    With the deepening of the concept of green building design, the course of university education gradually exposed many problems in the teaching of architectural design theory; based on the existing mode of teaching and combined with the needs of architectural design practice it proposed the "integrated" method of green building design. It…

  1. EPR design tools. Integrated data processing tools

    International Nuclear Information System (INIS)

    Kern, R.

    1997-01-01

    In all technical areas, planning and design have been supported by electronic data processing for many years. New data processing tools had to be developed for the European Pressurized Water Reactor (EPR). The work to be performed was split between KWU and Framatome and laid down in the Basic Design contract. The entire plant was reduced to a logical data structure; the circuit diagrams and flowsheets of the systems were drafted, the central data pool was established, the outlines of building structures were defined, the layout of plant components was planned, and the electrical systems were documented. Also building construction engineering was supported by data processing. The tasks laid down in the Basic Design were completed as so-called milestones. Additional data processing tools also based on the central data pool are required for the phases following after the Basic Design phase, i.e Basic Design Optimization; Detailed Design; Management; Construction, and Commissioning. (orig.) [de

  2. Integrated Design as an Evolutive Transdisciplinary Strategy

    OpenAIRE

    Bujar Bajçinovci; Florina Jerliu

    2016-01-01

    New challenges should stimulate new research, in order to provide better and higher quality of life. The essence of transdisciplinary design consists of different professions closely related to architectural design aiming for better and qualitative solutions, which with new findings exceed the usual and conventional disciplinary boundaries. Incentive mechanism for lateral thinking in the design process is accomplished when all the team members overcome a conventional barrier, in creating fund...

  3. Design of Integrated Circuits Approaching Terahertz Frequencies

    DEFF Research Database (Denmark)

    Yan, Lei

    In this thesis, monolithic microwave integrated circuits(MMICs) are presented for millimeter-wave and submillimeter-wave or terahertz(THz) applications. Millimeter-wave power generation from solid state devices is not only crucial for the emerging high data rate wireless communications but also...... heterodyne receivers with requirements of room temperature operation, low system complexity, and high sensitivity, monolithic integrated Schottky diode technology is chosen for the implementation of submillimeterwave components. The corresponding subharmonic mixer and multiplier for a THz radiometer system...

  4. Integrated magnetics design for HF-link power converters

    Energy Technology Data Exchange (ETDEWEB)

    Ljusev, P.; Andersen, Michael A.E.

    2005-07-01

    This paper deals with the design of integrated magnetics for HF-link converters, where the two integrated magnetic components on the same core do not necessarily belong to the same voltage loop. Depending on the specific HF-link converter topology, the proposed integrated magnetics can either alleviate the derivation of independent auxiliary supply voltages from the main transformer or integrate other magnetic structures, thus saving board space and cutting costs. (au)

  5. Integrating Mediators and Moderators in Research Design

    Science.gov (United States)

    MacKinnon, David P.

    2011-01-01

    The purpose of this article is to describe mediating variables and moderating variables and provide reasons for integrating them in outcome studies. Separate sections describe examples of moderating and mediating variables and the simplest statistical model for investigating each variable. The strengths and limitations of incorporating mediating…

  6. Integrated Design Tools for Embedded Control Systems

    NARCIS (Netherlands)

    Jovanovic, D.S.; Hilderink, G.H.; Broenink, Johannes F.; Karelse, F.

    2001-01-01

    Currently, computer-based control systems are still being implemented using the same techniques as 10 years ago. The purpose of this project is the development of a design framework, consisting of tools and libraries, which allows the designer to build high reliable heterogeneous real-time embedded

  7. An iterative method for selecting degenerate multiplex PCR primers.

    Science.gov (United States)

    Souvenir, Richard; Buhler, Jeremy; Stormo, Gary; Zhang, Weixiong

    2007-01-01

    Single-nucleotide polymorphism (SNP) genotyping is an important molecular genetics process, which can produce results that will be useful in the medical field. Because of inherent complexities in DNA manipulation and analysis, many different methods have been proposed for a standard assay. One of the proposed techniques for performing SNP genotyping requires amplifying regions of DNA surrounding a large number of SNP loci. To automate a portion of this particular method, it is necessary to select a set of primers for the experiment. Selecting these primers can be formulated as the Multiple Degenerate Primer Design (MDPD) problem. The Multiple, Iterative Primer Selector (MIPS) is an iterative beam-search algorithm for MDPD. Theoretical and experimental analyses show that this algorithm performs well compared with the limits of degenerate primer design. Furthermore, MIPS outperforms an existing algorithm that was designed for a related degenerate primer selection problem.

  8. The Los Alamos primer

    CERN Document Server

    Serber, Robert

    2018-01-01

    Unabridged declassified value reproduction of The Los Alamos Primer by Robert Serber, in full color with all censor markings. This is the booklet given to new workers at Los Alamos during World War II, to catch them up on how to build a practical fission bomb. The Primer was driven by Robert Oppenheimer asking his protégé Robert Serber to summarize all knowledge and possible solutions known as of April 1943 in a series of lectures. Serber did such an excellent job that the notes from the series was turned into The Los Alamos Primer. Serber was known as an expert that bridged theory and reality, and so was also chosen to be one of the first Americans to enter Hiroshima and Nagasaki to assess the atomic damage in 1945.

  9. Cooling water systems design using process integration

    CSIR Research Space (South Africa)

    Gololo, KV

    2010-09-01

    Full Text Available Cooling water systems are generally designed with a set of heat exchangers arranged in parallel. This arrangement results in higher cooling water flowrate and low cooling water return temperature thus reducing cooling tower efficiency. Previous...

  10. Design Tools for Integrated Asynchronous Electronic Circuits

    National Research Council Canada - National Science Library

    Martin, Alain

    2003-01-01

    ..., simulation, verification, at the logical and physical levels. Situs has developed a business model for the commercialization of the CAD tools, and has designed the prototype of the tool suite based on this business model and the Caltech approach...

  11. Integrated Approach to Industrial Packaging Design

    Science.gov (United States)

    Vorobeva, O.

    2017-11-01

    The article reviews studies in the field of industrial packaging design. The major factors which influence technological, ergonomic, economic and ecological features of packaging are established. The main modern trends in packaging design are defined, the principles of marketing communications and their influence on consumers’ consciousness are indicated, and the function of packaging as a transmitter of brand values is specified. Peculiarities of packaging technology and printing techniques in modern printing industry are considered. The role of designers in the stage-by-stage development of the construction, form and graphic design concept of packaging is defined. The examples of authentic packaging are given and the mention of the tetrahedron packaging history is made. At the end of the article, conclusions on the key research aspects are made.

  12. Integration of MGDS design into the licensing process

    International Nuclear Information System (INIS)

    1997-12-01

    This paper presents an overview of how the Mined Geologic Disposal System (MGDS) design for a potential repository is integrated into the licensing process. The integration process employs a two-told approach: (1) ensure that the MGDS design complies with applicable Nuclear Regulatory Commission (NRC) licensing requirements, and (2) ensure that the MGDS design is appropriately reflected in a license application that is acceptable to the NRC for performing acceptance and compliance reviews

  13. Design of Integrated Circuits Approaching Terahertz Frequencies

    OpenAIRE

    Yan, Lei; Johansen, Tom Keinicke

    2013-01-01

    In this thesis, monolithic microwave integrated circuits(MMICs) are presented for millimeter-wave and submillimeter-wave or terahertz(THz) applications. Millimeter-wave power generation from solid state devices is not only crucial for the emerging high data rate wireless communications but also important for driving THz signal sources. To meet the requirement of high output power, amplifiers based on InP double heterojunction bipolar transistor (DHBT) devices from the III-V Lab in Marcoussic,...

  14. Integrated circuits, and design and manufacture thereof

    Science.gov (United States)

    Auracher, Stefan; Pribbernow, Claus; Hils, Andreas

    2006-04-18

    A representation of a macro for an integrated circuit layout. The representation may define sub-circuit cells of a module. The module may have a predefined functionality. The sub-circuit cells may include at least one reusable circuit cell. The reusable circuit cell may be configured such that when the predefined functionality of the module is not used, the reusable circuit cell is available for re-use.

  15. Integrated Design Tools for Embedded Control Systems

    OpenAIRE

    Jovanovic, D.S.; Hilderink, G.H.; Broenink, Johannes F.; Karelse, F.

    2001-01-01

    Currently, computer-based control systems are still being implemented using the same techniques as 10 years ago. The purpose of this project is the development of a design framework, consisting of tools and libraries, which allows the designer to build high reliable heterogeneous real-time embedded systems in a very short time at a fraction of the present day costs. The ultimate focus of current research is on transformation control laws to efficient concurrent algorithms, with concerns about...

  16. Safety design integrated in the building delivery system

    DEFF Research Database (Denmark)

    Jørgensen, Kirsten

    2013-01-01

    . The purpose of this article is to demonstrate how safety and health can be integrated in the design phases integrated in the management delivery systems within construction, The method for the research was to go through the building delivery system step by step and create a normative description of what, when......In construction, it is important to view safety and health as an integrated part of the way that “designers” are working. The designers cowers architects, constructors, engineers and others who carry out their consulting services in the design phase of a construction project. The philosophy...... and how to fully integrate safety in each part of the process. The result is a concept and guideline including control forms for how to integrate safety design in the Building Delivery System plus what to do and when. The concept has been tested in an educational context. The practical value...

  17. China Energy Primer

    Energy Technology Data Exchange (ETDEWEB)

    Ni, Chun Chun

    2009-11-16

    Based on extensive analysis of the 'China Energy Databook Version 7' (October 2008) this Primer for China's Energy Industry draws a broad picture of China's energy industry with the two goals of helping users read and interpret the data presented in the 'China Energy Databook' and understand the historical evolution of China's energy inustry. Primer provides comprehensive historical reviews of China's energy industry including its supply and demand, exports and imports, investments, environment, and most importantly, its complicated pricing system, a key element in the analysis of China's energy sector.

  18. Novel integrated design framework for radio frequency quadrupoles

    International Nuclear Information System (INIS)

    Jolly, Simon; Easton, Matthew; Lawrie, Scott; Letchford, Alan; Pozimski, Jürgen; Savage, Peter

    2014-01-01

    A novel design framework for Radio Frequency Quadrupoles (RFQs), developed as part of the design of the FETS RFQ, is presented. This framework integrates several previously disparate steps in the design of RFQs, including the beam dynamics design, mechanical design, electromagnetic, thermal and mechanical modelling and beam dynamics simulations. Each stage of the design process is described in detail, including the various software options and reasons for the final software suite selected. Results are given for each of these steps, describing how each stage affects the overall design process, with an emphasis on the resulting design choices for the FETS RFQ

  19. Integrating 3D modeling, photogrammetry and design

    CERN Document Server

    Foster, Shaun

    2014-01-01

    This book looks at the convergent nature of technology and its relationship to the field of photogrammetry and 3D design. This is a facet of a broader discussion of the nature of technology itself and the relationship of technology to art, as well as an examination of the educational process. In the field of technology-influenced design-based education it is natural to push for advanced technology, yet within a larger institution the constraints of budget and adherence to tradition must be accepted. These opposing forces create a natural balance; in some cases constraints lead to greater creat

  20. Integrated Energy Design in Master Planning

    DEFF Research Database (Denmark)

    Strømann-Andersen, Jakob Bjørn

    This PhD thesis considers urban structure and buildings in an energy correlation and use the knowledge to design energy- and comfort-optimized cities and buildings. The parameters are: the structure of nature, the city and the landscape, both in terms of geometry and interrelationships and in terms...... in character as daylight is taken into account. Furthermore the results suggest that there are limits to urban densification (200-300%) as an energy optimization strategy. The solar energy and daylight potential should be considered, and indeed protected, as a common resource in urban design. The most...

  1. On the Integration of Digital Design and Analysis Tools

    DEFF Research Database (Denmark)

    Klitgaard, Jens; Kirkegaard, Poul Henning

    2006-01-01

    The aim of this research is to look into integrated digital design and analysis tools in order to find out if it is suited for use by architects and designers or only by specialists and technicians - and if not, then to look at what can be done to make them more available to architects and design...

  2. High School Engineering and Technology Education Integration through Design Challenges

    Science.gov (United States)

    Mentzer, Nathan

    2011-01-01

    This study contextualized the use of the engineering design process by providing descriptions of how each element in a design process was integrated in an eleventh grade industry and engineering systems course. The guiding research question for this inquiry was: How do students engage in the engineering design process in a course where technology…

  3. Model reduction in integrated controls-structures design

    Science.gov (United States)

    Maghami, Peiman G.

    1993-01-01

    It is the objective of this paper to present a model reduction technique developed for the integrated controls-structures design of flexible structures. Integrated controls-structures design problems are typically posed as nonlinear mathematical programming problems, where the design variables consist of both structural and control parameters. In the solution process, both structural and control design variables are constantly changing; therefore, the dynamic characteristics of the structure are also changing. This presents a problem in obtaining a reduced-order model for active control design and analysis which will be valid for all design points within the design space. In other words, the frequency and number of the significant modes of the structure (modes that should be included) may vary considerably throughout the design process. This is also true as the locations and/or masses of the sensors and actuators change. Moreover, since the number of design evaluations in the integrated design process could easily run into thousands, any feasible order-reduction method should not require model reduction analysis at every design iteration. In this paper a novel and efficient technique for model reduction in the integrated controls-structures design process, which addresses these issues, is presented.

  4. Food product design. An integrated approach

    NARCIS (Netherlands)

    Linnemann, A.R.; Boekel, van M.A.J.S.

    2007-01-01

    This book explains how to apply barrier technology in food production to improve product stability and the possibilities of modelling and statistics in food product design are elaborated. Attention is given to Life Cycle Assessment as a method to determine the environmental impact of a food from

  5. Thinking Tracks for Integrated Systems Design

    NARCIS (Netherlands)

    Bonnema, Gerrit Maarten; Denkena, B.; Gausemeijer, J.; Scholz-Reiter, B.

    2012-01-01

    The paper investigates systems thinking and systems engineering. After a short literature review, the paper presents, as a means for systems thinking, twelve thinking tracks. The tracks can be used as creativity starter, checklist, and as means to investigate effects of design decisions taken early

  6. Integration of Design and Control through Model Analysis

    DEFF Research Database (Denmark)

    Russel, Boris Mariboe; Henriksen, Jens Peter; Jørgensen, Sten Bay

    2002-01-01

    A systematic computer aided analysis of the process model is proposed as a pre-solution step for integration of design and control problems. The process model equations are classified in terms of balance equations, constitutive equations and conditional equations. Analysis of the phenomena models...... (structure selection) issues for the integrated problems are considered. (C) 2002 Elsevier Science Ltd. All rights reserved....... representing the constitutive equations identify the relationships between the important process and design variables, which help to understand, define and address some of the issues related to integration of design and control. Furthermore, the analysis is able to identify a set of process (control) variables...

  7. Designing primers and evaluation of the efficiency of propidium monoazide - Quantitative polymerase chain reaction for counting the viable cells of Lactobacillus gasseri and Lactobacillus salivarius.

    Science.gov (United States)

    Lai, Chieh-Hsien; Wu, Sih-Rong; Pang, Jen-Chieh; Ramireddy, Latha; Chiang, Yu-Cheng; Lin, Chien-Ku; Tsen, Hau-Yang

    2017-07-01

    The purpose of this study is to evaluate the efficiency of using propidium monoazide (PMA) real-time quantitative polymerase chain reaction (qPCR) to count the viable cells of Lactobacillus gasseri and Lactobacillus salivarius in probiotic products. Based on the internal transcription spacer and 23S rRNA genes, two primer sets specific for these two Lactobacillus species were designed. For a probiotic product, the total deMan Rogosa Sharpe plate count was 8.65±0.69 log CFU/g, while for qPCR, the cell counts of L. gasseri and L. salivarius were 8.39±0.14 log CFU/g and 8.57±0.24 log CFU/g, respectively. Under the same conditions, for its heat-killed product, qPCR counts for L. gasseri and L. salivarius were 6.70±0.16 log cells/g and 7.67±0.20 log cells/g, while PMA-qPCR counts were 5.33±0.18 log cells/g and 5.05±0.23 log cells/g, respectively. For cell dilutions with a viable cell count of 8.5 log CFU/mL for L. gasseri and L. salivarius, after heat killing, the PMA-qPCR count for both Lactobacillus species was near 5.5 log cells/mL. When the PMA-qPCR counts of these cell dilutions were compared before and after heat killing, although some DNA might be lost during the heat killing, significant qPCR signals from dead cells, i.e., about 4-5 log cells/mL, could not be reduced by PMA treatment. Increasing PMA concentrations from 100 μM to 200 μM or light exposure time from 5 minutes to 15 minutes had no or, if any, only minor effect on the reduction of qPCR signals from their dead cells. Thus, to differentiate viable lactic acid bacterial cells from dead cells using the PMA-qPCR method, the efficiency of PMA to reduce the qPCR signals from dead cells should be notable. Copyright © 2016. Published by Elsevier B.V.

  8. Designing primers and evaluation of the efficiency of propidium monoazide – Quantitative polymerase chain reaction for counting the viable cells of Lactobacillus gasseri and Lactobacillus salivarius

    Directory of Open Access Journals (Sweden)

    Chieh-Hsien Lai

    2017-07-01

    Full Text Available The purpose of this study is to evaluate the efficiency of using propidium monoazide (PMA real-time quantitative polymerase chain reaction (qPCR to count the viable cells of Lactobacillus gasseri and Lactobacillus salivarius in probiotic products. Based on the internal transcription spacer and 23S rRNA genes, two primer sets specific for these two Lactobacillus species were designed. For a probiotic product, the total deMan Rogosa Sharpe plate count was 8.65±0.69 log CFU/g, while for qPCR, the cell counts of L. gasseri and L. salivarius were 8.39±0.14 log CFU/g and 8.57±0.24 log CFU/g, respectively. Under the same conditions, for its heat-killed product, qPCR counts for L. gasseri and L. salivarius were 6.70±0.16 log cells/g and 7.67±0.20 log cells/g, while PMA-qPCR counts were 5.33±0.18 log cells/g and 5.05±0.23 log cells/g, respectively. For cell dilutions with a viable cell count of 8.5 log CFU/mL for L. gasseri and L. salivarius, after heat killing, the PMA-qPCR count for both Lactobacillus species was near 5.5 log cells/mL. When the PMA-qPCR counts of these cell dilutions were compared before and after heat killing, although some DNA might be lost during the heat killing, significant qPCR signals from dead cells, i.e., about 4–5 log cells/mL, could not be reduced by PMA treatment. Increasing PMA concentrations from 100 μM to 200 μM or light exposure time from 5 minutes to 15 minutes had no or, if any, only minor effect on the reduction of qPCR signals from their dead cells. Thus, to differentiate viable lactic acid bacterial cells from dead cells using the PMA-qPCR method, the efficiency of PMA to reduce the qPCR signals from dead cells should be notable.

  9. Workspace design: Integrating ergonomics into the design of production systems

    DEFF Research Database (Denmark)

    Broberg, Ole

    2006-01-01

    The work practice of ergonomists in workplace-making processes was studied by a socio-technical framework. This resulted in the term ‘political reflective navigator’ as a conceptualization of the identified work practice and competencies. In order to strengthen the impact of ergonomists it was fo......The work practice of ergonomists in workplace-making processes was studied by a socio-technical framework. This resulted in the term ‘political reflective navigator’ as a conceptualization of the identified work practice and competencies. In order to strengthen the impact of ergonomists...... it was found that new ways and tools for influencing the design of production systems are needed. The concept of workspace design and ‘staging the workspace design’ is suggested as a new framework for seeing and guiding ergonomists when taking part in design of workplaces and production systems....

  10. Semantic Web Primer

    NARCIS (Netherlands)

    Antoniou, Grigoris; Harmelen, Frank van

    2004-01-01

    The development of the Semantic Web, with machine-readable content, has the potential to revolutionize the World Wide Web and its use. A Semantic Web Primer provides an introduction and guide to this still emerging field, describing its key ideas, languages, and technologies. Suitable for use as a

  11. Blue green component and integrated urban design

    Directory of Open Access Journals (Sweden)

    Stanković Srđan M.

    2016-01-01

    Full Text Available This paper aims to demonstrate the hidden potential of blue green components, in a synergetic network, not as separate systems, like used in past. The innovative methodology of the project Blue Green Dream is presented through examples of good practice. A new approach in the project initiate thoughtful planning and remodeling of the settlement for the modern man. Professional and scientific public is looking for way to create more healthy and stimulating place for living. However, offered integrative solutions still remain out of urban and architectural practice. Tested technologies in current projects confirmed measurability of innovative approaches and lessons learned. Scientific and professional contributions are summarized in master's and doctoral theses that have been completed or are in process of writing.

  12. Slide layout and integrated design (SLIDE) program

    International Nuclear Information System (INIS)

    Roberts, S.G.

    1975-01-01

    SLIDE is a FORTRAN IV program for producing 35 mm color slides on the Control Data CYBER-74. SLIDE interfaces with the graphics package, DISSPLA, on the CYBER-74. It was designed so that persons with no previous computer experience can easily and quickly generate their own textual 35 mm color slides for verbal presentations. SLIDE's features include seven different colors, five text sizes, ten tab positions, and two page sizes. As many slides as desired may be produced during any one run of the program. Each slide is designed to represent an 8 1 / 2 in. x 11 in. or an 11 in. x 8 1 / 2 in. page. The input data cards required to run the SLIDE program and the program output are described. Appendixes contain a sample program run showing input, output, and the resulting slides produced and a FORTRAN listing of the SLIDE program. (U.S.)

  13. Designing with ethnography : an integrative approach to CSCW design

    NARCIS (Netherlands)

    Iqbal, Rahat; James, A.; Gatward, R.

    2005-01-01

    This paper presents a part of wider research endeavor within the field of Computer Supported Cooperative Work (CSCW) to leverage the use of ethnography for systems design. It investigates the role of ethnography in the development of CSCW systems and its relevance to real world problems,

  14. Strategic Mobility 21: Integrated Tracking System Analysis and Concept Design

    National Research Council Canada - National Science Library

    Mallon, Lawrence G; Savacool, Edwin

    2007-01-01

    .... This design document supports the SM21 efforts in developing a dual-use multi-modal node at the Southern California Logistics Airport in Victorville, CA that will be supported by an Integrated Tracking System...

  15. Sensitivity Analysis for Design Optimization Integrated Software Tools, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of this proposed project is to provide a new set of sensitivity analysis theory and codes, the Sensitivity Analysis for Design Optimization Integrated...

  16. On the logistics effects of integrated product and package design

    DEFF Research Database (Denmark)

    Bramklev, Caroline; Hansen, Claus Thorp

    2007-01-01

    obtaining error-free deliveries, saving costs and avoiding quality problems. Thus, the authors of this paper see a challenge in developing the theory and methodology for Integrated Product and Package Design. In this paper we take a first step in this direction. Firstly, we have carried out a broad review...... of literature, which shows that there is a need for research into Integrated Product and Package Design. Secondly, we have analysed three cases from industrial practice, which show that a conscious and integrated design of product and package has positive logistics effects, whereas neglecting this issue might...... result in higher costs and quality problems. On the basis of these cases we have made an initial cross-case analysis, which indicates that it is possible to develop the terminology and methodology for Integrated Product and Package Design....

  17. Integration of case study approach, project design and computer ...

    African Journals Online (AJOL)

    Integration of case study approach, project design and computer modeling in managerial accounting education ... Journal of Fundamental and Applied Sciences ... in the Laboratory of Management Accounting and Controlling Systems at the ...

  18. Conceptual design of main coolant pump for integral reactor SMART

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jin Seok; Kim, Jong In; Kim, Min Hwan [Korea Atomic Energy Research Institute, Taejon (Korea)

    1999-12-01

    The conceptual design for MCP to be installed in the integral reactor SMART was carried out. Canned motor pump was adopted in the conceptual design of MCP. Three-dimensional modeling was performed to visualize the conceptual design of the MCP and to check interferences between the parts. The theoretical design procedure for the impeller was developed. The procedures for the flow field and structural analysis of impeller was also developed to assess the design validity and to verify its structural integrity. A computer program to analyze the dynamic characteristics of the rotor shaft of MCP was developed. The rotational speed sensor was designed and its performance test was conducted to verify the possibility of operation. A prototypes of the canned motor was manufactured and tested to confirm the validity of the design concept. The MCP design concept was also investigated for fabricability by establishing the manufacturing procedures. 41 refs., 96 figs., 10 tabs. (Author)

  19. Integrating computer programs for engineering analysis and design

    Science.gov (United States)

    Wilhite, A. W.; Crisp, V. K.; Johnson, S. C.

    1983-01-01

    The design of a third-generation system for integrating computer programs for engineering and design has been developed for the Aerospace Vehicle Interactive Design (AVID) system. This system consists of an engineering data management system, program interface software, a user interface, and a geometry system. A relational information system (ARIS) was developed specifically for the computer-aided engineering system. It is used for a repository of design data that are communicated between analysis programs, for a dictionary that describes these design data, for a directory that describes the analysis programs, and for other system functions. A method is described for interfacing independent analysis programs into a loosely-coupled design system. This method emphasizes an interactive extension of analysis techniques and manipulation of design data. Also, integrity mechanisms exist to maintain database correctness for multidisciplinary design tasks by an individual or a team of specialists. Finally, a prototype user interface program has been developed to aid in system utilization.

  20. Design dis-integration Silent, Partial, and Disparate Design

    OpenAIRE

    Stevens, John; Moultrie, James; Crilly, Nathan

    2009-01-01

    Michael Porter’s frameworks for analysing and planning competitive differentiation (Porter 1980, 1985) are established ‘textbook’ tools, widely taught to business students today. As the claim of design’s strategic importance is increasingly heard, we ask where does design fit in established strategy thinking? This paper documents a proposed conceptual model based on Porter’s value chain model for strategic planning. The concept outlined is the result of the first stage of a larger study of ...

  1. Implementing Integrated Multicultural Instructional Design in Management Education

    Science.gov (United States)

    Schultz, Jennifer L.; Higbee, Jeanne L.

    2011-01-01

    This purpose of this paper is to summarize the principles of integrated multicultural instructional design (IMID; Higbee, Goff, & Schultz, in press; Higbee, Schultz, & Goff, 2010) and present specific strategies for incorporating IMID in management education. The primary goal of IMID is to promote the integration of multicultural content…

  2. Integrated structure/control design - Present methodology and future opportunities

    Science.gov (United States)

    Weisshaar, T. A.; Newsom, J. R.; Zeiler, T. A.; Gilbert, M. G.

    1986-01-01

    Attention is given to current methodology applied to the integration of the optimal design process for structures and controls. Multilevel linear decomposition techniques proved to be most effective in organizing the computational efforts necessary for ISCD (integrated structures and control design) tasks. With the development of large orbiting space structures and actively controlled, high performance aircraft, there will be more situations in which this concept can be applied.

  3. Study on integrated design and analysis platform of NPP

    International Nuclear Information System (INIS)

    Lu Dongsen; Gao Zuying; Zhou Zhiwei

    2001-01-01

    Many calculation software have been developed to nuclear system's design and safety analysis, such as structure design software, fuel design and manage software, thermal hydraulic analysis software, severe accident simulation software, etc. This study integrates those software to a platform, develops visual modeling tool for Retran, NGFM90. And in this platform, a distribution calculation method is also provided for couple calculation between different software. The study will improve the design and analysis of NPP

  4. Engineering and industrial design : an integrated interdisciplinary design theory

    OpenAIRE

    Brezing, Alexander Nikolaus; Löwer, Manuel

    2009-01-01

    It is generally accepted that superior products result from a balanced consideration of both “technology” and “aesthetic design”. Nonetheless, the gap between the two professions of the “design engineer“ and the “industrial designer“ has not been bridged since their origination in the course of industrialization [7]. One possible approach to enhance the collaboration of both disciplines is to teach the basics of the respective other’s. In Germany, the main work following this approach of tryi...

  5. Design and Evaluation of Illumina MiSeq-Compatible, 18S rRNA Gene-Specific Primers for Improved Characterization of Mixed Phototrophic Communities.

    Science.gov (United States)

    Bradley, Ian M; Pinto, Ameet J; Guest, Jeremy S

    2016-10-01

    The use of high-throughput sequencing technologies with the 16S rRNA gene for characterization of bacterial and archaeal communities has become routine. However, the adoption of sequencing methods for eukaryotes has been slow, despite their significance to natural and engineered systems. There are large variations among the target genes used for amplicon sequencing, and for the 18S rRNA gene, there is no consensus on which hypervariable region provides the most suitable representation of diversity. Additionally, it is unclear how much PCR/sequencing bias affects the depiction of community structure using current primers. The present study amplified the V4 and V8-V9 regions from seven microalgal mock communities as well as eukaryotic communities from freshwater, coastal, and wastewater samples to examine the effect of PCR/sequencing bias on community structure and membership. We found that degeneracies on the 3' end of the current V4-specific primers impact read length and mean relative abundance. Furthermore, the PCR/sequencing error is markedly higher for GC-rich members than for communities with balanced GC content. Importantly, the V4 region failed to reliably capture 2 of the 12 mock community members, and the V8-V9 hypervariable region more accurately represents mean relative abundance and alpha and beta diversity. Overall, the V4 and V8-V9 regions show similar community representations over freshwater, coastal, and wastewater environments, but specific samples show markedly different communities. These results indicate that multiple primer sets may be advantageous for gaining a more complete understanding of community structure and highlight the importance of including mock communities composed of species of interest. The quantification of error associated with community representation by amplicon sequencing is a critical challenge that is often ignored. When target genes are amplified using currently available primers, differential amplification efficiencies

  6. Integration of rocket turbine design and analysis through computer graphics

    Science.gov (United States)

    Hsu, Wayne; Boynton, Jim

    1988-01-01

    An interactive approach with engineering computer graphics is used to integrate the design and analysis processes of a rocket engine turbine into a progressive and iterative design procedure. The processes are interconnected through pre- and postprocessors. The graphics are used to generate the blade profiles, their stacking, finite element generation, and analysis presentation through color graphics. Steps of the design process discussed include pitch-line design, axisymmetric hub-to-tip meridional design, and quasi-three-dimensional analysis. The viscous two- and three-dimensional analysis codes are executed after acceptable designs are achieved and estimates of initial losses are confirmed.

  7. Integral design small nuclear power plant UNITHERM

    International Nuclear Information System (INIS)

    Adamovich, L. A.; Grechko, G. I.; Ulasevich, V. K.; Shishkin, V. A.

    1995-01-01

    The need to erect expensive energy transmission lines to these places demands to use independent local energy sources. Therefore, a reasonable alternative to the plants fired fossil fuel, mostly hydrocarbon fuel, may come from the nuclear power plants (NPP) of relatively small capacity which are nonattended, shipped to the site by large-assembled modules and completely withdrawable from the site during decommissioning. Application of NPPs for power and heat supply may prove to be cost-efficient and rather positive from social and ecological point of view. UNITHERM NPP belongs to such energy sources and may be used for heat and power supply. Heat can be provided both as hot water and superheated steam. The consumers are able to specify heat/energy supply ratio. NPP design provides for independent energy supply to the consumers and the possibility to disconnect each of them without disruption of operation of the others. Thermal hydraulic diagram of UNITHERM NPP provides for the use of three interconnected, process circuits. The consumers of thermal energy (turbogenerator unit and boilers of the central heating unit) are arranged in the last circuit

  8. Implications of intelligent, integrated microsystems for product design and development

    International Nuclear Information System (INIS)

    MYERS, DAVID R.; MCWHORTER, PAUL J.

    2000-01-01

    Intelligent, integrated microsystems combine some or all of the functions of sensing, processing information, actuation, and communication within a single integrated package, and preferably upon a single silicon chip. As the elements of these highly integrated solutions interact strongly with each other, the microsystem can be neither designed nor fabricated piecemeal, in contrast to the more familiar assembled products. Driven by technological imperatives, microsystems will best be developed by multi-disciplinary teams, most likely within the flatter, less hierarchical organizations. Standardization of design and process tools around a single, dominant technology will expedite economically viable operation under a common production infrastructure. The production base for intelligent, integrated microsystems has elements in common with the mathematical theory of chaos. Similar to chaos theory, the development of microsystems technology will be strongly dependent on, and optimized to, the initial product requirements that will drive standardization--thereby further rewarding early entrants to integrated microsystem technology

  9. Development of integrated platform for computational material design

    Energy Technology Data Exchange (ETDEWEB)

    Kiyoshi, Matsubara; Kumi, Itai; Nobutaka, Nishikawa; Akifumi, Kato [Center for Computational Science and Engineering, Fuji Research Institute Corporation (Japan); Hideaki, Koike [Advance Soft Corporation (Japan)

    2003-07-01

    The goal of our project is to design and develop a problem-solving environment (PSE) that will help computational scientists and engineers develop large complicated application software and simulate complex phenomena by using networking and parallel computing. The integrated platform, which is designed for PSE in the Japanese national project of Frontier Simulation Software for Industrial Science, is defined by supporting the entire range of problem solving activity from program formulation and data setup to numerical simulation, data management, and visualization. A special feature of our integrated platform is based on a new architecture called TASK FLOW. It integrates the computational resources such as hardware and software on the network and supports complex and large-scale simulation. This concept is applied to computational material design and the project 'comprehensive research for modeling, analysis, control, and design of large-scale complex system considering properties of human being'. Moreover this system will provide the best solution for developing large and complicated software and simulating complex and large-scaled phenomena in computational science and engineering. A prototype has already been developed and the validation and verification of an integrated platform will be scheduled by using the prototype in 2003. In the validation and verification, fluid-structure coupling analysis system for designing an industrial machine will be developed on the integrated platform. As other examples of validation and verification, integrated platform for quantum chemistry and bio-mechanical system are planned.

  10. Development of integrated platform for computational material design

    International Nuclear Information System (INIS)

    Kiyoshi, Matsubara; Kumi, Itai; Nobutaka, Nishikawa; Akifumi, Kato; Hideaki, Koike

    2003-01-01

    The goal of our project is to design and develop a problem-solving environment (PSE) that will help computational scientists and engineers develop large complicated application software and simulate complex phenomena by using networking and parallel computing. The integrated platform, which is designed for PSE in the Japanese national project of Frontier Simulation Software for Industrial Science, is defined by supporting the entire range of problem solving activity from program formulation and data setup to numerical simulation, data management, and visualization. A special feature of our integrated platform is based on a new architecture called TASK FLOW. It integrates the computational resources such as hardware and software on the network and supports complex and large-scale simulation. This concept is applied to computational material design and the project 'comprehensive research for modeling, analysis, control, and design of large-scale complex system considering properties of human being'. Moreover this system will provide the best solution for developing large and complicated software and simulating complex and large-scaled phenomena in computational science and engineering. A prototype has already been developed and the validation and verification of an integrated platform will be scheduled by using the prototype in 2003. In the validation and verification, fluid-structure coupling analysis system for designing an industrial machine will be developed on the integrated platform. As other examples of validation and verification, integrated platform for quantum chemistry and bio-mechanical system are planned

  11. The Application of Integrated Design System for HTR-PM Design

    International Nuclear Information System (INIS)

    Qi Shi; Xiaojing Kang

    2014-01-01

    SmartPlant Enterprise(SPE) developed by Intergraph from America is a new generation integrated solution for engineering design. Combined with the application in a nuclear engineering, this paper introduced the composition and the data flow of Integrated Design System established by SPE, analyzed the advantages and the insufficiency, and provided the direction of continuous improvement. (author)

  12. Formative Assessment Design for PDA Integrated Ecology Observation

    Science.gov (United States)

    Hung, Pi-Hsia; Lin, Yu-Fen; Hwang, Gwo-Jen

    2010-01-01

    Ubiquitous computing and mobile technologies provide a new perspective for designing innovative outdoor learning experiences. The purpose of this study is to propose a formative assessment design for integrating PDAs into ecology observations. Three learning activities were conducted in this study. An action research approach was applied to…

  13. Integrating ergonomics into engineering design: The role of objects

    DEFF Research Database (Denmark)

    Hall-Andersen, Lene Bjerg; Broberg, Ole

    2014-01-01

    The objective of this study was to explore the role of objects in integrating ergonomic knowledge in engineering design processes. An engineering design case was analyzed using the theoretical concepts of boundary objects and intermediary objects: Boundary objects facilitate collaboration between...

  14. Developing an Integrated Design Strategy for Chip Layout Optimization

    NARCIS (Netherlands)

    Wits, Wessel Willems; Jauregui Becker, Juan Manuel; van Vliet, Frank Edward; te Riele, G.J.

    2011-01-01

    This paper presents an integrated design strategy for chip layout optimization. The strategy couples both electric and thermal aspects during the conceptual design phase to improve chip performances; thermal management being one of the major topics. The layout of the chip circuitry is optimized

  15. Integration of Design and Control Through Model Analysis

    DEFF Research Database (Denmark)

    Russel, Boris Mariboe; Henriksen, Jens Peter; Jørgensen, Sten Bay

    2000-01-01

    of the phenomena models representing the process model identify the relationships between the important process and design variables, which help to understand, define and address some of the issues related to integration of design and control issues. The model analysis is highlighted through examples involving...... processes with mass and/or energy recycle. (C) 2000 Elsevier Science Ltd. All rights reserved....

  16. Defense Primer: DOD Contractors

    Science.gov (United States)

    2017-02-10

    functions, from intelligence analysis or software development to landscaping or food service. Why does DOD use individual contractors? Going back to...that provide professional services, from research to management support. The bulk of contractors—more than 70%—provide products, and these include...10 U.S.C. Part IV: Service, Supply, and Procurement. CRS Products CRS In Focus IF10548, Defense Primer: U.S. Defense Industrial Base, by Daniel

  17. Design Process for Integrated Concepts with Responsive Building Elements

    DEFF Research Database (Denmark)

    Aa, Van der A.; Heiselberg, Per

    2008-01-01

    An integrated building concept is a prerequisite to come to an energy efficient building with a good and healthy IAQ indoor comfort. A design process that defines the targets and boundary conditions in the very first stage of the design and guarantees them until the building is finished and used...... is needed. The hard question is however: how to make the right choice of the combination of individual measures from building components and building services elements. Within the framework of IEA-ECBCS Annex 44 research has been conducted about the design process for integrated building concepts...

  18. Consequence Based Design. An approach for integrating computational collaborative models (Integrated Dynamic Models) in the building design phase

    DEFF Research Database (Denmark)

    Negendahl, Kristoffer

    relies on various advancements in the area of integrated dynamic models. It also relies on the application and test of the approach in practice to evaluate the Consequence based design and the use of integrated dynamic models. As a result, the Consequence based design approach has been applied in five...... and define new ways to implement integrated dynamic models for the following project. In parallel, seven different developments of new methods, tools and algorithms have been performed to support the application of the approach. The developments concern: Decision diagrams – to clarify goals and the ability...... affect the design process and collaboration between building designers and simulationists. Within the limits of applying the approach of Consequence based design to five case studies, followed by documentation based on interviews, surveys and project related documentations derived from internal reports...

  19. A design approach for integrating thermoelectric devices using topology optimization

    International Nuclear Information System (INIS)

    Soprani, S.; Haertel, J.H.K.; Lazarov, B.S.; Sigmund, O.; Engelbrecht, K.

    2016-01-01

    Highlights: • The integration of a thermoelectric (TE) cooler into a robotic tool is optimized. • Topology optimization is suggested as design tool for TE integrated systems. • A 3D optimization technique using temperature dependent TE properties is presented. • The sensitivity of the optimization process to the boundary conditions is studied. • A working prototype is constructed and compared to the model results. - Abstract: Efficient operation of thermoelectric devices strongly relies on the thermal integration into the energy conversion system in which they operate. Effective thermal integration reduces the temperature differences between the thermoelectric module and its thermal reservoirs, allowing the system to operate more efficiently. This work proposes and experimentally demonstrates a topology optimization approach as a design tool for efficient integration of thermoelectric modules into systems with specific design constraints. The approach allows thermal layout optimization of thermoelectric systems for different operating conditions and objective functions, such as temperature span, efficiency, and power recovery rate. As a specific application, the integration of a thermoelectric cooler into the electronics section of a downhole oil well intervention tool is investigated, with the objective of minimizing the temperature of the cooled electronics. Several challenges are addressed: ensuring effective heat transfer from the load, minimizing the thermal resistances within the integrated system, maximizing the thermal protection of the cooled zone, and enhancing the conduction of the rejected heat to the oil well. The design method incorporates temperature dependent properties of the thermoelectric device and other materials. The 3D topology optimization model developed in this work was used to design a thermoelectric system, complete with insulation and heat sink, that was produced and tested. Good agreement between experimental results and

  20. Development of SCAR marker specific to non-toxic Jatropha curcas L. and designing a novel multiplexing PCR along with nrDNA ITS primers to circumvent the false negative detection

    KAUST Repository

    Mastan, Shaik G.

    2011-05-10

    Jatropha curcas L., a multipurpose shrub, has acquired significant economic importance for its seed oil which can be converted to biodiesel an emerging alternative to petro-diesel. In addition to the commercial value, it is also having medicinal and even high nutritional value to use as animal fodder which is limited due to the toxicity. Development of molecular marker will enable to differentiate non-toxic from toxic variety of J. curcas in a mixed population and also for quality control since the toxic components of J. curcas has deleterious effect on animals. In the present study, the efforts were made to generate the specific SCAR marker for toxic and/or non-toxic J. curcas from RAPD markers. Among the markers specific for toxic and non-toxic varieties, four were selected, purified, cloned, sequenced, and designed primers out of which one set of primers NT-JC/SCAR I/OPQ15-F and R could able to discriminate the non-toxic with toxic Jatropha by giving expected 430 bp size amplification in non-toxic variety. Furthermore, novel multiplex PCR was designed using the nrDNA ITS primers to overcome the false negatives. Present work also demonstrates utility of the conserved regions of nrDNA coding genes in ruling out the artifacts in PCR-like false negatives frequently occur in SCAR due to various reasons. The specific SCAR markers generated in the present investigation will help to distinguish non-toxic from toxic varieties of J. curcas or vice versa, and isolated marker along with designed multiplex protocol has applications in quality control for selective cultivation of non-toxic variety and will also assist in breeding and molecular mapping studies. © 2011 Springer Science+Business Media, LLC.

  1. System 80+ integrated design of a complete plant

    International Nuclear Information System (INIS)

    Turk, R.S.; Stamm, S.L.; Fox, W.A.

    1992-01-01

    In 1985, ABB-Combustion Engineering Nuclear Power (ABB-CENP) and elements of Duke Power Company [now Duke Engineering ampersand Services (DE ampersand S)] joined forces under the aegis of the Electric Power Research Institute (EPRI) Advanced Light Water Reactor (ALWR) Program to develop, with the sponsoring utilities, the design requirements for the next generation of nuclear power plants. With support from the US Department of Energy, ABB-CENP and DE ampersand S again teamed up the following year to initiate a project to design and license the System 80+ standard plant design, an advanced pressurized water reactor that meets these utility requirements. A distinguishing feature of the System 80+ standard design is that it is an essentially complete plant, predesigned and prelicensed to ensure rapid and economical construction. This is in stark contrast to typical prior conduct, where the reactor vendor offered only the nuclear steam supply system and the plant was built on a design-as-you-go basis with constant pressure to release individual elements of the plant design for construction or procurement as soon as possible. Now, however, the design process can be integrated over the total plant, ensuring that the goals set for ALWRs can be met. This integrated design process is manifested in several ways: (1) broad-based participation during the design process by involving designers, analysts, suppliers, constructors, and operators; (2) use of probabilistic risk assessment (PRA) as a design tool to aid in evaluating design features on a total-plant basis; (3) application of human factors engineering methods to a total plant distributed control system to improve the human-machine interface in the design; and (4) use of computer-aided design to enhance assessment of interactions and impacts of all aspects of the total plant. Each of these aspects of integrated plant design is discussed in this paper

  2. Development of core design and analyses technology for integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Zee, Sung Quun; Lee, C. C.; Song, J. S. and others

    1999-03-01

    Integral reactors are developed for the applications such as sea water desalination, heat energy for various industries, and power sources for large container ships. In order to enhance the inherent and passive safety features, low power density concept is chosen for the integral reactor SMART. Moreover, ultra-longer cycle and boron-free operation concepts are reviewed for better plant economy and simple design of reactor system. Especially, boron-free operation concept brings about large difference in core configurations and reactivity controls from those of the existing large size commercial nuclear power plants and also causes many differences in the safety aspects. The ultimate objectives of this study include detailed core design of a integral reactor, development of the core design system and technology, and finally acquisition of the system design certificate. The goal of the first stage is the conceptual core design, that is, to establish the design bases and requirements suitable for the boron-free concept, to develop a core loading pattern, to analyze the nuclear, thermal and hydraulic characteristics of the core and to perform the core shielding design. Interface data for safety and performance analyses including fuel design data are produced for the relevant design analysis groups. Nuclear, thermal and hydraulic, shielding design and analysis code systems necessary for the core conceptual design are established through modification of the existing design tools and newly developed methodology and code modules. Core safety and performance can be improved by the technology development such as boron-free core optimization, advaned core monitoring and operational aid system. Feasiblity study on the improvement of the core protection and monitoring system will also contribute toward core safety and performance. Both the conceptual core design study and the related technology will provide concrete basis for the next design phase. This study will also

  3. Development of core design and analyses technology for integral reactor

    International Nuclear Information System (INIS)

    Zee, Sung Quun; Lee, C. C.; Song, J. S. and others

    1999-03-01

    Integral reactors are developed for the applications such as sea water desalination, heat energy for various industries, and power sources for large container ships. In order to enhance the inherent and passive safety features, low power density concept is chosen for the integral reactor SMART. Moreover, ultra-longer cycle and boron-free operation concepts are reviewed for better plant economy and simple design of reactor system. Especially, boron-free operation concept brings about large difference in core configurations and reactivity controls from those of the existing large size commercial nuclear power plants and also causes many differences in the safety aspects. The ultimate objectives of this study include detailed core design of a integral reactor, development of the core design system and technology, and finally acquisition of the system design certificate. The goal of the first stage is the conceptual core design, that is, to establish the design bases and requirements suitable for the boron-free concept, to develop a core loading pattern, to analyze the nuclear, thermal and hydraulic characteristics of the core and to perform the core shielding design. Interface data for safety and performance analyses including fuel design data are produced for the relevant design analysis groups. Nuclear, thermal and hydraulic, shielding design and analysis code systems necessary for the core conceptual design are established through modification of the existing design tools and newly developed methodology and code modules. Core safety and performance can be improved by the technology development such as boron-free core optimization, advaned core monitoring and operational aid system. Feasiblity study on the improvement of the core protection and monitoring system will also contribute toward core safety and performance. Both the conceptual core design study and the related technology will provide concrete basis for the next design phase. This study will also

  4. Spacecraft System Integration and Test: SSTI Lewis critical design audit

    Science.gov (United States)

    Brooks, R. P.; Cha, K. K.

    1995-01-01

    The Critical Design Audit package is the final detailed design package which provides a comprehensive description of the SSTI mission. This package includes the program overview, the system requirements, the science and applications activities, the ground segment development, the assembly, integration and test description, the payload and technology demonstrations, and the spacecraft bus subsystems. Publication and presentation of this document marks the final requirements and design freeze for SSTI.

  5. Integral Monitored Retrievable Storage (MRS) Facility conceptual basis for design

    International Nuclear Information System (INIS)

    1985-10-01

    The purpose of the Conceptual Basis for Design is to provide a control document that establishes the basis for executing the conceptual design of the Integral Monitored Retrievable Storage (MRS) Facility. This conceptual design shall provide the basis for preparation of a proposal to Congress by the Department of Energy (DOE) for construction of one or more MRS Facilities for storage of spent nuclear fuel, high-level radioactive waste, and transuranic (TRU) waste. 4 figs., 25 tabs

  6. A Primer on Observational Measurement.

    Science.gov (United States)

    Girard, Jeffrey M; Cohn, Jeffrey F

    2016-08-01

    Observational measurement plays an integral role in a variety of scientific endeavors within biology, psychology, sociology, education, medicine, and marketing. The current article provides an interdisciplinary primer on observational measurement; in particular, it highlights recent advances in observational methodology and the challenges that accompany such growth. First, we detail the various types of instrument that can be used to standardize measurements across observers. Second, we argue for the importance of validity in observational measurement and provide several approaches to validation based on contemporary validity theory. Third, we outline the challenges currently faced by observational researchers pertaining to measurement drift, observer reactivity, reliability analysis, and time/expense. Fourth, we describe recent advances in computer-assisted measurement, fully automated measurement, and statistical data analysis. Finally, we identify several key directions for future observational research to explore.

  7. Digital integrated circuit design using Verilog and SystemVerilog

    CERN Document Server

    Mehler, Ronald W

    2014-01-01

    For those with a basic understanding of digital design, this book teaches the essential skills to design digital integrated circuits using Verilog and the relevant extensions of SystemVerilog. In addition to covering the syntax of Verilog and SystemVerilog, the author provides an appreciation of design challenges and solutions for producing working circuits. The book covers not only the syntax and limitations of HDL coding, but deals extensively with design problems such as partitioning and synchronization, helping you to produce designs that are not only logically correct, but will actually

  8. Parametric design and analysis framework with integrated dynamic models

    DEFF Research Database (Denmark)

    Negendahl, Kristoffer

    2014-01-01

    of building energy and indoor environment, are generally confined to late in the design process. Consequence based design is a framework intended for the early design stage. It involves interdisciplinary expertise that secures validity and quality assurance with a simulationist while sustaining autonomous...... control with the building designer. Consequence based design is defined by the specific use of integrated dynamic modeling, which includes the parametric capabilities of a scripting tool and building simulation features of a building performance simulation tool. The framework can lead to enhanced...

  9. Integrated Design Process in Problem-Based Learning

    DEFF Research Database (Denmark)

    Knudstrup, Mary-Ann

    2004-01-01

    This article reports and reflects on the learning achievements and the educational experiences in connection with the first years of the curriculum in Architecture at Aalborg University ?s Civil Engineer Education in Architecture & Design. In the article I will focus on the learning activity and ...... the students need in order to concentrate, mobilize creativity and find the personal design language which is a precondition for making good architecture....... and the method that are developed during the semester when working with an Integrated Design Process combining architecture, design, functional aspects, energy consumption, indoor environment, technology, and construction. I will emphasize the importance of working with different tools in the design process, e...

  10. Cryogenic propellant management: Integration of design, performance and operational requirements

    Science.gov (United States)

    Worlund, A. L.; Jamieson, J. R., Jr.; Cole, T. W.; Lak, T. I.

    1985-01-01

    The integration of the design features of the Shuttle elements into a cryogenic propellant management system is described. The implementation and verification of the design/operational changes resulting from design deficiencies and/or element incompatibilities encountered subsequent to the critical design reviews are emphasized. Major topics include: subsystem designs to provide liquid oxygen (LO2) tank pressure stabilization, LO2 facility vent for ice prevention, liquid hydrogen (LH2) feedline high point bleed, pogo suppression on the Space Shuttle Main Engine (SSME), LO2 low level cutoff, Orbiter/engine propellant dump, and LO2 main feedline helium injection for geyser prevention.

  11. Integrating Thermal Tools Into the Mechanical Design Process

    Science.gov (United States)

    Tsuyuki, Glenn T.; Siebes, Georg; Novak, Keith S.; Kinsella, Gary M.

    1999-01-01

    The intent of mechanical design is to deliver a hardware product that meets or exceeds customer expectations, while reducing cycle time and cost. To this end, an integrated mechanical design process enables the idea of parallel development (concurrent engineering). This represents a shift from the traditional mechanical design process. With such a concurrent process, there are significant issues that have to be identified and addressed before re-engineering the mechanical design process to facilitate concurrent engineering. These issues also assist in the integration and re-engineering of the thermal design sub-process since it resides within the entire mechanical design process. With these issues in mind, a thermal design sub-process can be re-defined in a manner that has a higher probability of acceptance, thus enabling an integrated mechanical design process. However, the actual implementation is not always problem-free. Experience in applying the thermal design sub-process to actual situations provides the evidence for improvement, but more importantly, for judging the viability and feasibility of the sub-process.

  12. Development of mechanical design technology for integral reactor

    International Nuclear Information System (INIS)

    Park, Keun Bae; Choi, Suhn; Kim, Kang Soo; Kim, Tae Wan; Jeong, Kyeong Hoon; Lee, Gyu Mahn

    1999-03-01

    While Korean nuclear reactor strategy seems to remain focused on the large capacity power generation, it is expected that demand of small and medium size reactor will arise for multi-purpose application such as small capacity power generation, co-generation and sea water desalination. With this in mind, an integral reactor SMART is under development. Design concepts, system layout and types of equipment of integral reactor are significantly different from those of loop type reactor. Conceptual design development of mechanical structures of integral reactor SMART is completed through the first stage of the project. Efforts were endeavored for the establishment of design basis and evaluation of applicable codes and standards. Design and functional requirements of major structural components were set up, and three dimensional structural modelling of SMART reactor vessel assembly was prepared. Also, maintenance and repair scheme as well as preliminary fabricability evaluation were carried out. Since small integral reactor technology includes sensitive technologies and know-how's, it is hard to achieve systematic and comprehensive technology transfer from nuclear-advanced countries. Thus, it is necessary to develop the related design technology and to verify the adopted methodologies through test and experiments in order to assure the structural integrity of reactor system. (author)

  13. Development of mechanical design technology for integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Park, Keun Bae; Choi, Suhn; Kim, Kang Soo; Kim, Tae Wan; Jeong, Kyeong Hoon; Lee, Gyu Mahn

    1999-03-01

    While Korean nuclear reactor strategy seems to remain focused on the large capacity power generation, it is expected that demand of small and medium size reactor will arise for multi-purpose application such as small capacity power generation, co-generation and sea water desalination. With this in mind, an integral reactor SMART is under development. Design concepts, system layout and types of equipment of integral reactor are significantly different from those of loop type reactor. Conceptual design development of mechanical structures of integral reactor SMART is completed through the first stage of the project. Efforts were endeavored for the establishment of design basis and evaluation of applicable codes and standards. Design and functional requirements of major structural components were setup, and three dimensional structural modelling of SMART reactor vessel assembly was prepared. Also, maintenance and repair scheme as well as preliminary fabricability evaluation were carried out. Since small integral reactor technology includes sensitive technologies and know-how's, it is hard to achieve systematic and comprehensive technology transfer from nuclear-advanced countries. Thus, it is necessary to develop the related design technology and to verify the adopted methodologies through test and experiments in order to assure the structural integrity of reactor system. (author)

  14. Integrating Safeguards and Security with Safety into Design

    International Nuclear Information System (INIS)

    Bean, Robert S.; Hockert, John W.; Hebditch, David J.

    2009-01-01

    There is a need to minimize security risks, proliferation hazards, and safety risks in the design of new nuclear facilities in a global environment of nuclear power expansion, while improving the synergy of major design features and raising operational efficiency. In 2008, the U.S. Department of Energy (DOE), National Nuclear Security Administration (NNSA) launched the Next Generation Safeguards Initiative (NGSI) covering many safeguards areas. One of these, launched by NNSA with support of the DOE Office of Nuclear Energy, was a multi-laboratory project, led by the Idaho National Laboratory (INL), to develop safeguards by design. The proposed Safeguards-by-Design (SBD) process has been developed as a structured approach to ensure the timely, efficient, and cost effective integration of international safeguards and other nonproliferation barriers with national material control and accountability, physical security, and safety objectives into the overall design process for the nuclear facility lifecycle. A graded, iterative process was developed to integrate these areas throughout the project phases. It identified activities, deliverables, interfaces, and hold points covering both domestic regulatory requirements and international safeguards using the DOE regulatory environment as exemplar to provide a framework and guidance for project management and integration of safety with security during design. Further work, reported in this paper, created a generalized SBD process which could also be employed within the licensed nuclear industry and internationally for design of new facilities. Several tools for integrating safeguards, safety, and security into design are discussed here. SBD appears complementary to the EFCOG TROSSI process for security and safety integration created in 2006, which focuses on standardized upgrades to enable existing DOE facilities to meet a more severe design basis threat. A collaborative approach is suggested.

  15. Design of an integrated I and C system

    International Nuclear Information System (INIS)

    Lee, C. K.; Oh, I. S.; Kim, D. H.

    2004-08-01

    The final goal of this project is to develop an integrated I and C systems, and through this project the localized equipment and systems being developed should secure the safety, the reliability, their applicability and technical competitiveness. As well, the technical interfaces among sub-projects should be maintained for integration. The results of this project are as following ; 1. Development of an integrated I and C system architecture: Development of the design concepts for KNICS and the design requirements for each I and C system, Development of the design requirements of control systems based on DCS, Design of the communication systems, Design of the interface signals among systems and analysis of traffic load for networks, Conceptual design of measuring and monitoring systems, Review of the structure of computer systems for information processing, Development of architectures for each system and KOICS 2. Technological integration and management of projects: Development of evaluation criteria for DCS and network systems, Evaluation of the DCS prototype, Design review of KNICS protection system, Review of the functions and design requirements of I and C systems in NPP, Analysis of the I and C system H/W in NPP and the APR1400 I and C system design, Review of the technology criteria and the regulatory trend for licensing issues, Extracting items for preparing the technical description of I and C systems, a part of proposal to invitation to bid (ITB), Planning for KNICS to be of practical use The results of this project will be applied as design bases during the development of 2nd phase KNICS. As well it is expected that the results of this project will be finally applied for the technical self-reliance of component design and manufacturing of NPP I and C systems

  16. CopperCore Service Integration, Integrating IMS Learning Design and IMS Question and Test Interoperability

    NARCIS (Netherlands)

    Vogten, Hubert; Martens, Harrie; Nadolski, Rob; Tattersall, Colin; Van Rosmalen, Peter; Koper, Rob

    2006-01-01

    Vogten, H., Martens, H., Nadolski, R., Tattersall, C., Rosmalen, van, P., Koper, R., (2006). CopperCore Service Integration, Integrating IMS Learning Design and IMS Question and Test Interoperability. Proceedings of the 6th IEEE International Conference on Advanced Learning Technologies (pp.

  17. Integrating IMS Learning Design and IMS Question and Test Interoperability using CopperCore Service Integration

    NARCIS (Netherlands)

    Vogten, Hubert; Martens, Harrie; Nadolski, Rob; Tattersall, Colin; Van Rosmalen, Peter; Koper, Rob

    2006-01-01

    Please, cite this publication as: Vogten, H., Martens, H., Nadolski, R., Tattersall, C., van Rosmalen, P., & Koper, R. (2006). Integrating IMS Learning Design and IMS Question and Test Interoperability using CopperCore Service Integration. Proceedings of International Workshop in Learning Networks

  18. Suspended Integrated Strip-line Transition Design for Highly Integrated Radar Systems

    Science.gov (United States)

    2017-03-01

    technology. The measured results show good correlation to the simulated results with a return loss and insertion loss of less than 10 dB and greater...SSS); Suspended Integrated Strip-line (SISL) RF packaging; Ultra-wideband (UWB). Introduction The next generation of highly integrated radar...RF Circuit Design,” Second Edition, Pearson Education, 2009. 3. B. Ma, A. Chousseaud, and S. Toutain, “A new design of compact planar microstrip

  19. Requirements of Integrated Design Teams While Evaluating Advanced Energy Retrofit Design Options in Immersive Virtual Environments

    Directory of Open Access Journals (Sweden)

    Xue Yang

    2015-12-01

    Full Text Available One of the significant ways to save energy use in buildings is to implement advanced energy retrofits in existing buildings. Improving energy performance of buildings through advanced energy retrofitting requires a clear understanding of the cost and energy implications of design alternatives from various engineering disciplines when different retrofit options are considered. The communication of retrofit design alternatives and their energy implications is essential in the decision-making process, as it affects the final retrofit selections and hence the energy efficiency of the retrofitted buildings. The objective of the research presented here was to identify a generic list of information requirements that are needed to be shared and collectively analyzed by integrated design teams during advanced energy retrofit design review meetings held in immersive settings. While identifying such requirements, the authors used an immersive environment based iterative requirements elicitation approach. The technology was used as a means to better identify the information requirements of integrated design teams to be analyzed as a group. This paper provides findings on information requirements of integrated design teams when evaluating retrofit options in immersive virtual environments. The information requirements were identified through interactions with sixteen experts in design and energy modeling domain, and validated with another group of participants consisting of six design experts who were experienced in integrated design processes. Industry practitioners can use the findings in deciding on what information to share with integrated design team members during design review meetings that utilize immersive virtual environments.

  20. A design approach for integrating thermoelectric devices using topology optimization

    DEFF Research Database (Denmark)

    Soprani, Stefano; Haertel, Jan Hendrik Klaas; Lazarov, Boyan Stefanov

    2016-01-01

    Efficient operation of thermoelectric devices strongly relies on the thermal integration into the energy conversion system in which they operate. Effective thermal integration reduces the temperature differences between the thermoelectric module and its thermal reservoirs, allowing the system...... to operate more efficiently. This work proposes and experimentally demonstrates a topology optimization approach as a design tool for efficient integration of thermoelectric modules into systems with specific design constraints. The approach allows thermal layout optimization of thermoelectric systems...... for different operating conditions and objective functions, such as temperature span, efficiency, and power recoveryrate. As a specific application, the integration of a thermoelectric cooler into the electronics section ofa downhole oil well intervention tool is investigated, with the objective of minimizing...

  1. DESIGN OF INFORMATION MANAGEMENT SYSTEM OF VERTICALLY INTEGRATED AGRICULTURAL HOLDINGS

    Directory of Open Access Journals (Sweden)

    Александр Витальевич ШМАТКО

    2015-05-01

    Full Text Available The paper deals with an approach to the design and development of information systems for the management and optimization of the organizational structure of vertically integrated agricultural holdings. A review of the problems of building and improving the organizational structure of vertically integrated agricultural holding is made. A method of constructing a discrete model management structure agricultural holding, which minimizes the costs associated with attracting applicants to work, is proposed.

  2. Grid integration impacts on wind turbine design and development

    DEFF Research Database (Denmark)

    Hansen, Anca Daniela; Cutululis, Nicolaos Antonio; Sørensen, Poul Ejnar

    2009-01-01

    This paper presents an overall perspective on contemporary issues like wind power plants and grid integration. The purpose is to present and discuss the impacts of emerging new grid connection requirements on modern wind turbines. The grid integration issue has caused several new challenges......, the grid integration aspect has also an effect on wind turbines' role in the power system, on wind turbine technologies' survival on the market, as well as on the wind turbines' loads. Over the last years, it became obviously, that there it is an increasing need for design and research of wind turbines...... to the wind turbine design and development. The survival of different wind turbine concepts and controls is strongly conditioned by their ability to comply with stringent grid connection requirements, imposed by utility companies. Beside its impact on the mechanical design and control of wind turbines...

  3. Availability objectives integration to design. The CIDEM approach

    International Nuclear Information System (INIS)

    Degrave, C.; Martin-Onraet, M.

    1994-01-01

    Considering the operation experience feedback from its nuclear park and from foreign parks, and considering new approaches and design tools such as concurrent engineering, total quality, etc., EDF (Electricite de France) has decided to start the CIDEM approach (integration of availability, operating experience feedback and maintenance into design), an analytical and systematical study process for new projects (REP2000 (or PWR2000)), in order to optimize as much as possible the design phase while integrating maintenance, availability and safety objectives, with the view of a minimized kWh cost. This process, already used in other industries, employs concepts such as RAM (Reliability Availability Maintainability), RCM (Reliability Centered Maintenance) and ILS (Integrated Logistic Support). The availability and maintenance scheduling studies for the REP2000 project are detailed. 10 fig., 6 tab

  4. Design and evaluation of an integrated safeguards system: principles

    International Nuclear Information System (INIS)

    Markin, J.T.; Coulter, C.A.; Gutmacher, R.G.; Whitty, W.J.

    1984-07-01

    An integrated safeguards system is defined as a collection of safeguards activities in which system components are coordinated to meet safeguards objectives efficiently within constraints imposed by safeguards resources, facility operations, potential adversaries, and regulatory requirements. This paper describes principles for designing and evaluating an integrated safeguards system that consists of four parts: (1) a problem definition phase that specifies resources and constraints composing the problem boundary values; (2) a system analysis/synthesis phase that describes how to select and integrate safeguards activities for efficient attainment of system objectives; (3) a system evaluation/optimization phase that defines measures of safeguards performance and develops methods for evaluating them; and (4) a decision-making phase that develops principles for selecting admissible designs and preference-ordering designs. 6 references, 4 figures, 5 tables

  5. Design and evaluation of an integrated safeguards system: principles

    International Nuclear Information System (INIS)

    Markin, J.T.; Coulter, C.A.; Gutmacher, R.G.; Whitty, W.J.

    1984-01-01

    An integrated safeguards system is defined as a collection of safeguards activities in which system components are coordinated to meet safeguards objectives efficiently within constraints imposed by safeguards resources, facility operations, potential adversaries, and regulatory requirements. This paper describes principles for designing and evaluating an integrated safeguards system that consists of four parts: a problem definition phase that specifies resources and constraints composing the problem boundary values, a system analysis/synthesis phase that describes how to select and integrate safeguards activities for efficient attainment of system objectives, a system evaluation/optimization phase that defines measures of safeguards performance and develops methods for evaluating them, and a decision-making phase that develops principles for selecting admissible designs and preference-ordering designs

  6. The computational design of Geological Disposal Technology Integration System

    International Nuclear Information System (INIS)

    Ishihara, Yoshinao; Iwamoto, Hiroshi; Kobayashi, Shigeki; Neyama, Atsushi; Endo, Shuji; Shindo, Tomonori

    2002-03-01

    In order to develop 'Geological Disposal Technology Integration System' that is intended to systematize as knowledge base for fundamental study, the computational design of an indispensable database and image processing function to 'Geological Disposal Technology Integration System' was done, the prototype was made for trial purposes, and the function was confirmed. (1) Database of Integration System which systematized necessary information and relating information as an examination of a whole of repository composition and managed were constructed, and the system function was constructed as a system composed of image processing, analytical information management, the repository component management, and the system security function. (2) The range of the data treated with this system and information was examined, the design examination of the database structure was done, and the design examination of the image processing function of the data preserved in an integrated database was done. (3) The prototype of the database concerning a basic function, the system operation interface, and the image processing function was manufactured to verify the feasibility of the 'Geological Disposal Technology Integration System' based on the result of the design examination and the function was confirmed. (author)

  7. Design and control of integrated chromatography column sequences.

    Science.gov (United States)

    Andersson, Niklas; Löfgren, Anton; Olofsson, Marianne; Sellberg, Anton; Nilsson, Bernt; Tiainen, Peter

    2017-07-01

    To increase the productivity in biopharmaceutical production, a natural step is to introduce integrated continuous biomanufacturing which leads to fewer buffer and storage tanks, smaller sizes of integrated unit operations, and full automation of the operation. The main contribution of this work is to illustrate a methodology for design and control of a downstream process based on integrated column sequences. For small scale production, for example, pre-clinical studies, integrated column sequences can be implemented on a single chromatography system. This makes for a very efficient drug development platform. The proposed methodology is composed of four steps and is governed by a set of tools, that is presented, that makes the transition from batch separations to a complete integrated separation sequence as easy as possible. This methodology, its associated tools and the physical implementation is presented and illustrated on a case study where the target protein is separated from impurities through an integrated four column sequence. This article shows that the design and control of an integrated column sequence was successfully implemented for a tertiary protein separation problem. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 33:923-930, 2017. © 2017 American Institute of Chemical Engineers.

  8. Integral Monitored Retrievable Storage (MRS) Facility conceptual design report

    International Nuclear Information System (INIS)

    1985-09-01

    This report presents a summary design description of the Conceptual Design for an Integral Monitored Retrievable Storage (MRS) Facility, as prepared by The Ralph M. Parsons Company under an A-E services contract with the Richland Operations Office of the Department of Energy. More detailed design requirements and design data are set forth in the Basis for Design and Design Report, bound under separate cover and available for reference by those desiring such information. The design data provided in this Design Report Executive Summary, the Basis for Design, and the Design Report include contributions by the Waste Technology Services Division of Westinghouse Electric Corporation (WEC), which was responsible for the development of the waste receiving, packaging, and storage systems, and Golder Associates Incorporated (GAI), which supported the design development with program studies. The MRS Facility design requirements, which formed the basis for the design effort, were prepared by Pacific Northwest Laboratory for the US Department of Energy, Richland Operations Office, in the form of a Functional Design Criteria (FDC) document, Rev. 4, August 1985. 9 figs., 6 tabs

  9. Challenges and opportunities in integration of design and control

    DEFF Research Database (Denmark)

    Huusom, Jakob Kjøbsted

    2015-01-01

    Process synthesis and design of plant operation are related topics but current industrial practice solves these problems sequentially. The implication of this sequential strategy may result in design of processing systems which are very hard to control. This paper presents a discussion on drivers...... for an integrated approach and outlines the challenges in formulation of such a multi-objective synthesis problem. This discussion is viewed in relation to some of the changing trends in the industry. Significant results have been published which in different ways seek to handle the integrated problem. Further...

  10. A Novel Analog Integrated Circuit Design Course Covering Design, Layout, and Resulting Chip Measurement

    Science.gov (United States)

    Lin, Wei-Liang; Cheng, Wang-Chuan; Wu, Chen-Hao; Wu, Hai-Ming; Wu, Chang-Yu; Ho, Kuan-Hsuan; Chan, Chueh-An

    2010-01-01

    This work describes a novel, first-year graduate-level analog integrated circuit (IC) design course. The course teaches students analog circuit design; an external manufacturer then produces their designs in three different silicon chips. The students, working in pairs, then test these chips to verify their success. All work is completed within…

  11. Design criteria of integrated reactors based on transients

    International Nuclear Information System (INIS)

    Zanocco, P.; Gimenez, M.; Delmastro, D.

    1999-01-01

    A new tendency in integrated reactors conceptual design is to include safety criteria through accident analysis. In this work, the effect of design parameters in a Loss of Heat Sink transient using design maps is analyzed. Particularly, geometry related parameters and reactivity coefficients are studied. Also the effect of primary relief/safety valve during the transient is evaluated. A design map for valve area vs. coolant density reactivity coefficient is obtained. A computer code (HUARPE) is developed in order to simulate these transients. Coolant, steam dome, pressure vessel structures and core models are implemented. This code is checked against TRAC with satisfactory results. (author)

  12. Toshiba integrated information system for design of nuclear power plants

    International Nuclear Information System (INIS)

    Abe, Yoko; Kawamura, Hirobumi; Sasaki, Norio; Takasaka, Kiyoshi

    1993-01-01

    TOSHIBA aims to secure safety, increase reliability and improve efficiency through the engineering for nuclear power plants and has been introducing Computer Aided Engineering (CAE). Up to the present, TOSHIBA has been developing computer systems which support each field of design and applying them to the design of nuclear power plants. The new design support system has been developed to integrate each of those systems in order to realize much greater improvement in accuracy and increase of reliability in design using state-of-the-art computer technology

  13. Integrating design and purchasing [in nuclear engineering] with Ingecad

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    Ingecad was developed by the Ingevision division of Framatome to overcome deficiencies in traditional computer-aided design. It was developed for nuclear power project engineering around the principle of the shared management of a common database, thus making it possible to integrate several engineering disciplines. The multiuser database is managed and accessed by the different application softwares, corresponding to particular aspects of the engineering task: electrical and process control schematics; plant piping design; pressurized equipment design etc. The use of a common database ensures coherence between the different engineering disciplines, particularly between the process engineering, the plant layout design, the piping, and the instrumentation and control engineering. (author)

  14. A Quantum Groups Primer

    Science.gov (United States)

    Majid, Shahn

    2002-05-01

    Here is a self-contained introduction to quantum groups as algebraic objects. Based on the author's lecture notes for the Part III pure mathematics course at Cambridge University, the book is suitable as a primary text for graduate courses in quantum groups or supplementary reading for modern courses in advanced algebra. The material assumes knowledge of basic and linear algebra. Some familiarity with semisimple Lie algebras would also be helpful. The volume is a primer for mathematicians but it will also be useful for mathematical physicists.

  15. The R primer

    CERN Document Server

    Ekstrom, Claus Thorn

    2011-01-01

    Newcomers to R are often intimidated by the command-line interface, the vast number of functions and packages, or the processes of importing data and performing a simple statistical analysis. The R Primer provides a collection of concise examples and solutions to R problems frequently encountered by new users of this statistical software.Rather than explore the many options available for every command as well as the ever-increasing number of packages, the book focuses on the basics of data preparation and analysis and gives examples that can be used as a starting point. The numerous examples i

  16. Primer on Health Surveys

    Directory of Open Access Journals (Sweden)

    David L Nordstrom

    2012-06-01

    Full Text Available The aim of this paper is to introduce novice researchers to surveys as a method of data collection. It starts with the definition of a survey, its major purposes and types as well as changes in the goals surveys have helped to achieve over time. Advantages and disadvantages of surveys over population censuses and medical examinations are discussed. Approaches to questionnaire construction are introduced along with properties that questionnaires are evaluated for. Modes of administration, sample size issues, and data analysis approaches are also introduced. The primer is illustrated with examples of surveys conducted in different countries with various public health purposes.

  17. Math primer for engineers

    CERN Document Server

    Cryer, CW

    2014-01-01

    Mathematics and engineering are inevitably interrelated, and this interaction will steadily increase as the use of mathematical modelling grows. Although mathematicians and engineers often misunderstand one another, their basic approach is quite similar, as is the historical development of their respective disciplines. The purpose of this Math Primer is to provide a brief introduction to those parts of mathematics which are, or could be, useful in engineering, especially bioengineering. The aim is to summarize the ideas covered in each subject area without going into exhaustive detail. Formula

  18. RUCS: Rapid identification of PCR primers for unique core sequences

    DEFF Research Database (Denmark)

    Thomsen, Martin Christen Frølund; Hasman, Henrik; Westh, Henrik

    2017-01-01

    Designing PCR primers to target a specific selection of whole genome sequenced strains can be a long, arduous, and sometimes impractical task. Such tasks would benefit greatly from an automated tool to both identify unique targets, and to validate the vast number of potential primer pairs...... for the targets in silico . Here we present RUCS, a program that will find PCR primer pairs and probes for the unique core sequences of a positive genome dataset complement to a negative genome dataset. The resulting primer pairs and probes are in addition to simple selection also validated through a complex...... in silico PCR simulation. We compared our method, which identifies the unique core sequences, against an existing tool called ssGeneFinder, and found that our method was 6.5-20 times more sensitive. We used RUCS to design primer pairs that would target a set of genomes known to contain the mcr-1 colistin...

  19. Integrated airfoil and blade design method for large wind turbines

    DEFF Research Database (Denmark)

    Zhu, Wei Jun; Shen, Wen Zhong; Sørensen, Jens Nørkær

    2014-01-01

    This paper presents an integrated method for designing airfoil families of large wind turbine blades. For a given rotor diameter and a tip speed ratio, optimal airfoils are designed based on the local speed ratios. To achieve a high power performance at low cost, the airfoils are designed...... with the objectives of high Cp and small chord length. When the airfoils are obtained, the optimum flow angle and rotor solidity are calculated which forms the basic input to the blade design. The new airfoils are designed based on a previous in-house designed airfoil family which was optimized at a Reynolds number...... of 3 million. A novel shape perturbation function is introduced to optimize the geometry based on the existing airfoils which simplifies the design procedure. The viscous/inviscid interactive code XFOIL is used as the aerodynamic tool for airfoil optimization at a Reynolds number of 16 million...

  20. Landing Gear Integration in Aircraft Conceptual Design. Revision

    Science.gov (United States)

    Chai, Sonny T.; Mason, William H.

    1997-01-01

    The design of the landing gear is one of the more fundamental aspects of aircraft design. The design and integration process encompasses numerous engineering disciplines, e.g., structure, weights, runway design, and economics, and has become extremely sophisticated in the last few decades. Although the design process is well-documented, no attempt has been made until now in the development of a design methodology that can be used within an automated environment. As a result, the process remains to be a key responsibility for the configuration designer and is largely experience-based and graphically-oriented. However, as industry and government try to incorporate multidisciplinary design optimization (MDO) methods in the conceptual design phase, the need for a more systematic procedure has become apparent. The development of an MDO-capable design methodology as described in this work is focused on providing the conceptual designer with tools to help automate the disciplinary analyses, i.e., geometry, kinematics, flotation, and weight. Documented design procedures and analyses were examined to determine their applicability, and to ensure compliance with current practices and regulations. Using the latest information as obtained from industry during initial industry survey, the analyses were in terms modified and expanded to accommodate the design criteria associated with the advanced large subsonic transports. Algorithms were then developed based on the updated analysis procedures to be incorporated into existing MDO codes.

  1. The challenge of integrating evidence-based design.

    Science.gov (United States)

    Martin, Caren S

    2009-01-01

    This paper discusses the integration of evidence-based design (EBD) into the design process as an innovation, illuminates the significance and progress of the diffusion of this innovation, and identifies EBD advocates and the consequences of meeting the EBD challenge. A free tool for engaging in EBD is explored. Healthcare designers are leading the EBD charge, because their clients depend on it. But not all designers engage in EBD, because it may be beyond the resources of a firm or outside its culture. However, as with other meaningful design innovations, designers who do not practice EBD could fall by the wayside. EBD is a product of the diffusion of the innovation of evidence-based medicine. The academy (i.e., the collective of institutions of higher education), design organizations, design communities, and the media all contribute to the diffusion of EBD. However, the quantity, quality, and understandability of evidence continue to challenge its broad adoption. InformeDesign®, a free, Internet-based tool, presents information to designers in a concise, understandable way. Firms must invest in EBD incrementally as a value-added component of design to meet current and future challenges. It is important for designers to realize that engaging in EBD is not a rejection of creativity, but a means by which to elevate their design solutions. ©2009 VENDOME GROUP, LLC

  2. Barriers and Challenges in the Integrated Design Process Approcach

    DEFF Research Database (Denmark)

    Knudstrup, Mary-Ann

    2006-01-01

    ABSTRACT: In the future, it will be a huge challenge to make sustainable building design by using a more holistic and innovative approach in order to be able to decrease or reduce the use of energy for heating and cooling in new building projects. This is seen in the perspective of the Kyoto agre....... It also describes the barriers and the challenges that must be overcome when trying to cross the borders between the two fields of engineering and architecture to design sustainable architecture....... agreement for reducing the global heating. This paper will briefly present the method of the Integrated Design Process, IDP [1]. It describes the background and means for developing a new method for designing integrated architecture in an interdisciplinary approach between architecture and engineering...

  3. Analog integrated circuits design for processing physiological signals.

    Science.gov (United States)

    Li, Yan; Poon, Carmen C Y; Zhang, Yuan-Ting

    2010-01-01

    Analog integrated circuits (ICs) designed for processing physiological signals are important building blocks of wearable and implantable medical devices used for health monitoring or restoring lost body functions. Due to the nature of physiological signals and the corresponding application scenarios, the ICs designed for these applications should have low power consumption, low cutoff frequency, and low input-referred noise. In this paper, techniques for designing the analog front-end circuits with these three characteristics will be reviewed, including subthreshold circuits, bulk-driven MOSFETs, floating gate MOSFETs, and log-domain circuits to reduce power consumption; methods for designing fully integrated low cutoff frequency circuits; as well as chopper stabilization (CHS) and other techniques that can be used to achieve a high signal-to-noise performance. Novel applications using these techniques will also be discussed.

  4. Design and development of small and medium integral reactor core

    International Nuclear Information System (INIS)

    Zee, Sung Quun; Chang, M. H.; Lee, C. C.; Song, J. S.; Cho, B. O.; Kim, K. Y.; Kim, S. J.; Park, S. Y.; Lee, K. B.; Lee, C. H.; Chun, T. H.; Oh, D. S.; In, W. K.; Kim, H. K.; Lee, C. B.; Kang, H. S.; Song, K. N.

    1997-07-01

    Recently, the role of small and medium size integral reactors is remarkable in the heat applications rather than the electrical generations. Such a range of possible applications requires extensive used of inherent safety features and passive safety systems. It also requires ultra-longer cycle operations for better plant economy. Innovative and evolutionary designs such as boron-free operations and related reactor control methods that are necessary for simple reactor system design are demanded for the small and medium reactor (SMR) design, which are harder for engineers to implement in the current large size nuclear power plants. The goals of this study are to establish preliminary design criteria, to perform the preliminary conceptual design and to develop core specific technology for the core design and analysis for System-integrated Modular Advanced ReacTor (SMART) of 330 MWt power. Based on the design criteria of the commercial PWR's, preliminary design criteria will be set up. Preliminary core design concept is going to be developed for the ultra-longer cycle and boron-free operation and core analysis code system is constructed for SMART. (author). 100 refs., 40 tabs., 92 figs

  5. A primer on pseudorandom generators

    CERN Document Server

    Goldreich, Oded

    2010-01-01

    A fresh look at the question of randomness was taken in the theory of computing: A distribution is pseudorandom if it cannot be distinguished from the uniform distribution by any efficient procedure. This paradigm, originally associating efficient procedures with polynomial-time algorithms, has been applied with respect to a variety of natural classes of distinguishing procedures. The resulting theory of pseudorandomness is relevant to science at large and is closely related to central areas of computer science, such as algorithmic design, complexity theory, and cryptography. This primer surveys the theory of pseudorandomness, starting with the general paradigm, and discussing various incarnations while emphasizing the case of general-purpose pseudorandom generators (withstanding any polynomial-time distinguisher). Additional topics include the "derandomization" of arbitrary probabilistic polynomial-time algorithms, pseudorandom generators withstanding space-bounded distinguishers, and several natural notions...

  6. Integral Engine Inlet Particle Separator. Volume 2. Design Guide

    Science.gov (United States)

    1975-08-01

    herein will be used in the design of integral inlet particle separators for future Army aircraft gas turbine engines. Apprupriate technical personnel...into the comprensor at some future date. 5. A typical scavenge vane design Js; shown in Figures 85 and 86. The important features of the scavenge...service passageweys, for cooling of oil, and for directing sand and air into the scroll. Orientetion of the vanes is set by collection efficiency

  7. Development of core design and analyses technology for integral reactor

    International Nuclear Information System (INIS)

    Zee, Sung Quun; Lee, C. C.; Kim, K. Y.

    2002-03-01

    In general, small and medium-sized integral reactors adopt new technology such as passive and inherent safety concepts to minimize the necessity of power source and operator actions, and to provide the automatic measures to cope with any accidents. Specifically, such reactors are often designed with a lower core power density and with soluble boron free concept for system simplification. Those reactors require ultra long cycle operation for higher economical efficiency. This cycle length requirement is one of the important factors in the design of burnable absorbers as well as assurance of shutdown margin. Hence, both computer code system and design methodology based on the today's design technology for the current commercial reactor cores require intensive improvement for the small and medium-sized soluble boron free reactors. New database is also required for the development of this type of reactor core. Under these technical requirements, conceptual design of small integral reactor SMART has been performed since July 1997, and recently completed under the long term nuclear R and D program. Thus, the final objectives of this work is design and development of an integral reactor core and development of necessary indigenous design technology. To reach the goal of the 2nd stage R and D program for basic design of SMART, design bases and requirements adequate for ultra long cycle and soluble boron free concept are established. These bases and requirements are satisfied by the core loading pattern. Based on the core loading pattern, nuclear, and thermal and hydraulic characteristics are analyzed. Also included are fuel performance analysis and development of a core protection and monitoring system that is adequate for the soluble boron free core of an integral reactor. Core shielding design analysis is accomplished, too. Moreover, full scope interface data are produced for reactor safety and performance analyses and other design activities. Nuclear, thermal and

  8. El primer virreinato americano

    Directory of Open Access Journals (Sweden)

    Cassá, Roberto

    2006-12-01

    Full Text Available This article explores the government of viceroy Christopher Columbus in the American territories. We return to the first Spanish settlement in Santo Domingo and the contradictions inherent to this expansionist proyect. The contradictions were part of the logic of the absolutist state and Columbus’ reaction against the controls imposed by the monarchs. Secondly, we look into the dificulties that the Admiral encountered to develop a mercantilist model. In this context, we examine the rationale behind the first government of the Indies and the features that defined the new West Indian society.

    El artículo trata sobre el gobierno de Cristóbal Colón en tierras americanas. Retomamos el tema del primer emplazamiento español en Santo Domingo y las contradicciones que tuvo aquel proyecto debido a la lógica del estado absolutista, a la ambición desmedida del descubridor y a su reacción ante los controles que desde un principio impusieron los monarcas. En un segundo momento analizamos las dificultades que encontró el Almirante para desarrollar un modelo mercantilista acorde a sus ideas y a los acuerdos a que llegó con la Corona. En ese contexto analizamos la lógica del primer gobierno colombinista en las Indias y los rasgos que definieron la nueva sociedad antillana.

  9. First large-scale DNA barcoding assessment of reptiles in the biodiversity hotspot of Madagascar, based on newly designed COI primers.

    Science.gov (United States)

    Nagy, Zoltán T; Sonet, Gontran; Glaw, Frank; Vences, Miguel

    2012-01-01

    DNA barcoding of non-avian reptiles based on the cytochrome oxidase subunit I (COI) gene is still in a very early stage, mainly due to technical problems. Using a newly developed set of reptile-specific primers for COI we present the first comprehensive study targeting the entire reptile fauna of the fourth-largest island in the world, the biodiversity hotspot of Madagascar. Representatives of the majority of Madagascan non-avian reptile species (including Squamata and Testudines) were sampled and successfully DNA barcoded. The new primer pair achieved a constantly high success rate (72.7-100%) for most squamates. More than 250 species of reptiles (out of the 393 described ones; representing around 64% of the known diversity of species) were barcoded. The average interspecific genetic distance within families ranged from a low of 13.4% in the Boidae to a high of 29.8% in the Gekkonidae. Using the average genetic divergence between sister species as a threshold, 41-48 new candidate (undescribed) species were identified. Simulations were used to evaluate the performance of DNA barcoding as a function of completeness of taxon sampling and fragment length. Compared with available multi-gene phylogenies, DNA barcoding correctly assigned most samples to species, genus and family with high confidence and the analysis of fewer taxa resulted in an increased number of well supported lineages. Shorter marker-lengths generally decreased the number of well supported nodes, but even mini-barcodes of 100 bp correctly assigned many samples to genus and family. The new protocols might help to promote DNA barcoding of reptiles and the established library of reference DNA barcodes will facilitate the molecular identification of Madagascan reptiles. Our results might be useful to easily recognize undescribed diversity (i.e. novel taxa), to resolve taxonomic problems, and to monitor the international pet trade without specialized expert knowledge.

  10. First Large-Scale DNA Barcoding Assessment of Reptiles in the Biodiversity Hotspot of Madagascar, Based on Newly Designed COI Primers

    Science.gov (United States)

    Nagy, Zoltán T.; Sonet, Gontran; Glaw, Frank; Vences, Miguel

    2012-01-01

    Background DNA barcoding of non-avian reptiles based on the cytochrome oxidase subunit I (COI) gene is still in a very early stage, mainly due to technical problems. Using a newly developed set of reptile-specific primers for COI we present the first comprehensive study targeting the entire reptile fauna of the fourth-largest island in the world, the biodiversity hotspot of Madagascar. Methodology/Principal Findings Representatives of the majority of Madagascan non-avian reptile species (including Squamata and Testudines) were sampled and successfully DNA barcoded. The new primer pair achieved a constantly high success rate (72.7–100%) for most squamates. More than 250 species of reptiles (out of the 393 described ones; representing around 64% of the known diversity of species) were barcoded. The average interspecific genetic distance within families ranged from a low of 13.4% in the Boidae to a high of 29.8% in the Gekkonidae. Using the average genetic divergence between sister species as a threshold, 41–48 new candidate (undescribed) species were identified. Simulations were used to evaluate the performance of DNA barcoding as a function of completeness of taxon sampling and fragment length. Compared with available multi-gene phylogenies, DNA barcoding correctly assigned most samples to species, genus and family with high confidence and the analysis of fewer taxa resulted in an increased number of well supported lineages. Shorter marker-lengths generally decreased the number of well supported nodes, but even mini-barcodes of 100 bp correctly assigned many samples to genus and family. Conclusions/Significance The new protocols might help to promote DNA barcoding of reptiles and the established library of reference DNA barcodes will facilitate the molecular identification of Madagascan reptiles. Our results might be useful to easily recognize undescribed diversity (i.e. novel taxa), to resolve taxonomic problems, and to monitor the international pet trade

  11. Integrating rock mechanics issues with repository design through design process principles and methodology

    International Nuclear Information System (INIS)

    Bieniawski, Z.T.

    1996-01-01

    A good designer needs not only knowledge for designing (technical know-how that is used to generate alternative design solutions) but also must have knowledge about designing (appropriate principles and systematic methodology to follow). Concepts such as open-quotes design for manufactureclose quotes or open-quotes concurrent engineeringclose quotes are widely used in the industry. In the field of rock engineering, only limited attention has been paid to the design process because design of structures in rock masses presents unique challenges to the designers as a result of the uncertainties inherent in characterization of geologic media. However, a stage has now been reached where we are be able to sufficiently characterize rock masses for engineering purposes and identify the rock mechanics issues involved but are still lacking engineering design principles and methodology to maximize our design performance. This paper discusses the principles and methodology of the engineering design process directed to integrating site characterization activities with design, construction and performance of an underground repository. Using the latest information from the Yucca Mountain Project on geology, rock mechanics and starter tunnel design, the current lack of integration is pointed out and it is shown how rock mechanics issues can be effectively interwoven with repository design through a systematic design process methodology leading to improved repository performance. In essence, the design process is seen as the use of design principles within an integrating design methodology, leading to innovative problem solving. In particular, a new concept of open-quotes Design for Constructibility and Performanceclose quotes is introduced. This is discussed with respect to ten rock mechanics issues identified for repository design and performance

  12. Achieving integration in mixed methods designs-principles and practices.

    Science.gov (United States)

    Fetters, Michael D; Curry, Leslie A; Creswell, John W

    2013-12-01

    Mixed methods research offers powerful tools for investigating complex processes and systems in health and health care. This article describes integration principles and practices at three levels in mixed methods research and provides illustrative examples. Integration at the study design level occurs through three basic mixed method designs-exploratory sequential, explanatory sequential, and convergent-and through four advanced frameworks-multistage, intervention, case study, and participatory. Integration at the methods level occurs through four approaches. In connecting, one database links to the other through sampling. With building, one database informs the data collection approach of the other. When merging, the two databases are brought together for analysis. With embedding, data collection and analysis link at multiple points. Integration at the interpretation and reporting level occurs through narrative, data transformation, and joint display. The fit of integration describes the extent the qualitative and quantitative findings cohere. Understanding these principles and practices of integration can help health services researchers leverage the strengths of mixed methods. © Health Research and Educational Trust.

  13. Integrated design and manufacturing for the high speed civil transport

    Science.gov (United States)

    1993-01-01

    In June 1992, Georgia Tech's School of Aerospace Engineering was awarded a NASA University Space Research Association (USRA) Advanced Design Program (ADP) to address 'Integrated Design and Manufacturing for the High Speed Civil Transport (HSCT)' in its graduate aerospace systems design courses. This report summarizes the results of the five courses incorporated into the Georgia Tech's USRA ADP program. It covers AE8113: Introduction to Concurrent Engineering, AE4360: Introduction to CAE/CAD, AE4353: Design for Life Cycle Cost, AE6351: Aerospace Systems Design One, and AE6352: Aerospace Systems Design Two. AE8113: Introduction to Concurrent Engineering was an introductory course addressing the basic principles of concurrent engineering (CE) or integrated product development (IPD). The design of a total system was not the objective of this course. The goal was to understand and define the 'up-front' customer requirements, their decomposition, and determine the value objectives for a complex product, such as the high speed civil transport (HSCT). A generic CE methodology developed at Georgia Tech was used for this purpose. AE4353: Design for Life Cycle Cost addressed the basic economic issues for an HSCT using a robust design technique, Taguchi's parameter design optimization method (PDOM). An HSCT economic sensitivity assessment was conducted using a Taguchi PDOM approach to address the robustness of the basic HSCT design. AE4360: Introduction to CAE/CAD permitted students to develop and utilize CAE/CAD/CAM knowledge and skills using CATIA and CADAM as the basic geometric tools. AE6351: Aerospace Systems Design One focused on the conceptual design refinement of a baseline HSCT configuration as defined by Boeing, Douglas, and NASA in their system studies. It required the use of NASA's synthesis codes FLOPS and ACSYNT. A criterion called the productivity index (P.I.) was used to evaluate disciplinary sensitivities and provide refinements of the baseline HSCT

  14. The GOTTHARD charge integrating readout detector: design and characterization

    International Nuclear Information System (INIS)

    Mozzanica, A; Bergamaschi, A; Dinapoli, R; Greiffenberg, D; Henrich, B; Johnson, I; Valeria, R; Schmitt, B; Xintian, S; Graafsma, H; Lohmann, M

    2012-01-01

    A charge integrating readout ASIC (Application Specific Integrated Circuit) for silicon strip sensors has been developed at PSI in collaboration with DESY. The goal of the project is to provide a charge integrating readout system able to cope with the pulsed beam of XFEL machines and at the same time to retain the high dynamic range and single photon resolution performances typical for photon counting systems. The ASIC, designed in IBM 130 nm CMOS technology, takes advantage of its three gain stages with automatic stage selection to achieve a dynamic range of 10000 12 keV photons and a noise better than 300 e.n.c.. The 4 analog outputs of the ASIC are optimized for speed, allowing frame rates higher than 1 MHz, without compromises on linearity and noise performances. This work presents the design features of the ASIC, and reports the characterization results of the chip itself.

  15. Integrated seismic design of structure and control systems

    CERN Document Server

    Castaldo, Paolo

    2014-01-01

    The structural optimization procedure presented in this book makes it possible to achieve seismic protection through integrated structural/control system design. In particular, it is explained how slender structural systems with a high seismic performance can be achieved through inclusion of viscous and viscoelastic dampers as an integral part of the system. Readers are provided with essential introductory information on passive structural control and passive energy dissipation systems. Dynamic analyses of both single and multiple degree of freedom systems are performed in order to verify the achievement of pre-assigned performance targets, and it is explained how the optimal integrated design methodology, also relevant to retrofitting of existing buildings, should be applied. The book illustrates how structural control research is opening up new possibilities in structural forms and configurations without compromising structural performance.

  16. On CAD-integrated Structural Topology and Design Optimization

    DEFF Research Database (Denmark)

    Olhoff, Niels; Bendsøe, M.P.; Rasmussen, John

    1991-01-01

    Concepts underlying an interactive CAD-based engineering design optimization system are developed, and methods of optimizing the topology, shape and sizing of mechanical components are presented. These methods are integrated in the system, and the method for determining the optimal topology is used...

  17. Designing the Distributed Model Integration Framework – DMIF

    NARCIS (Netherlands)

    Belete, Getachew F.; Voinov, Alexey; Morales, Javier

    2017-01-01

    We describe and discuss the design and prototype of the Distributed Model Integration Framework (DMIF) that links models deployed on different hardware and software platforms. We used distributed computing and service-oriented development approaches to address the different aspects of

  18. Overview of design issues in product-integrated Photovoltaics

    NARCIS (Netherlands)

    Apostolou, G.; Reinders, Angelina H.M.E.

    2014-01-01

    This paper presents an overview of the design features and characteristics of photovoltaic (PV)-powered products based on a literature study on product-integrated PV and an analysis of 90 PV-powered products executed during 2011–2013. The aim of this paper is to provide insight into the current

  19. Design and control of integrated styrene aniline production plant

    NARCIS (Netherlands)

    Partenie, O.; Van der Last, V.; Sorin Bildea, C.; Altimari, P.

    2009-01-01

    This paper illustrates the operational difficulties arising from simultaneously performing exothermic and endothermic reactions, and demonstrates that a plant can be built and safely operated by integrating the design and plantwide control issues. The behaviour of reactor – separation – recycle

  20. The design of high performance weak current integrated amplifier

    International Nuclear Information System (INIS)

    Chen Guojie; Cao Hui

    2005-01-01

    A design method of high performance weak current integrated amplifier using ICL7650 operational amplifier is introduced. The operating principle of circuits and the step of improving amplifier's performance are illustrated. Finally, the experimental results are given. The amplifier has programmable measurement range of 10 -9 -10 -12 A, automatic zero-correction, accurate measurement, and good stability. (authors)

  1. Human-Centered Design as an Integrating Discipline

    Directory of Open Access Journals (Sweden)

    Guy André Boy

    2017-02-01

    Full Text Available What is research today? Good research has to be indexed within appropriate mechanisms to be visible, considered and finally useful. These mechanisms are based on quantitative research methods and codes that are often very academic. Consequently, they impose rigorous constraints on the way results should be obtained and presented. In addition, everything people learn in academia needs to be graded. This leads to standard packaging of what should be learned and results in making people executants and not creators nor inventors. In other words, this academic standardization precludes freedom for innovation. This paper proposes Human-Centered Design (HCD as a solution to override these limitations and roadblocks. HCD involves expertise, experience, participation, modeling and simulation, complexity analysis and qualitative research. What is education today? Education is organized in silos with little attempt to integrate individual academic disciplines. Large system integration is almost never learned in engineering schools, and Human- Systems Integration (HSI even less. Instead, real-life problemsolving requires integration skills. What is design research? We often hear that design has nothing to do with research, and conversely. Putting design and research together, as complementary disciplines, contributes to combine creativity, rigorous demonstration and validation. This is somehow what HCD is about.

  2. Optical System Design and Integration of the Mercury Laser Altimeter

    Science.gov (United States)

    Ramos-Izquierdo, Luis; Scott, V. Stanley, III; Schmidt, Stephen; Britt, Jamie; Mamakos, William; Trunzo, Raymond; Cavanaugh, John; Miller, Roger

    2005-01-01

    The Mercury Laser Altimeter (MLA). developed for the 2004 MESSENGER mission to Mercury, is designed to measure the planet's topography via laser ranging. A description of the MLA optical system and its measured optical performance during instrument-level and spacecraft-level integration and testing are presented.

  3. Integrating ergonomics into engineering design: the role of objects.

    Science.gov (United States)

    Hall-Andersen, Lene Bjerg; Broberg, Ole

    2014-05-01

    The objective of this study was to explore the role of objects in integrating ergonomic knowledge in engineering design processes. An engineering design case was analyzed using the theoretical concepts of boundary objects and intermediary objects: Boundary objects facilitate collaboration between different knowledge domains, while the aim of an intermediary object is to circulate knowledge and thus produce a distant effect. Adjustable layout drawings served as boundary objects and had a positive impact on the dialog between an ergonomist and designers. An ergonomic guideline document was identified as an intermediary object. However, when the ergonomic guidelines were circulated in the design process, only some of the guidelines were transferred to the design of the sterile processing plant. Based on these findings, recommendations for working with objects in design processes are included. Copyright © 2013 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  4. Integrated airfoil and blade design method for large wind turbines

    DEFF Research Database (Denmark)

    Zhu, Wei Jun; Shen, Wen Zhong

    2013-01-01

    This paper presents an integrated method for designing airfoil families of large wind turbine blades. For a given rotor diameter and tip speed ratio, the optimal airfoils are designed based on the local speed ratios. To achieve high power performance at low cost, the airfoils are designed...... with an objective of high Cp and small chord length. When the airfoils are obtained, the optimum flow angle and rotor solidity are calculated which forms the basic input to the blade design. The new airfoils are designed based on the previous in-house airfoil family which were optimized at a Reynolds number of 3...... million. A novel shape perturbation function is introduced to optimize the geometry on the existing airfoils and thus simplify the design procedure. The viscos/inviscid code Xfoil is used as the aerodynamic tool for airfoil optimization where the Reynolds number is set at 16 million with a free...

  5. ITER design, integration and assembly studies assisted by virtual reality

    Energy Technology Data Exchange (ETDEWEB)

    Keller, D., E-mail: delphine.keller@cea.fr [CEA, IRFM, F-13108 St-Paul-Lez-Durance (France); ITER Organization, Route de Vinon-sur-Verdon, F-13115 St-Paul-Lez-Durance (France); Doceul, L.; Ferlay, F.; Jiolat, G. [CEA, IRFM, F-13108 St-Paul-Lez-Durance (France); Cordier, J.J.; Kuehn, I.; Manfreo, B.; Reich, J. [ITER Organization, Route de Vinon-sur-Verdon, F-13115 St-Paul-Lez-Durance (France)

    2013-10-15

    Highlights: ► VR technologies applied to Fusion enable to better and faster understand integration issues. ► Problems are solved and validated on a numerical mock up. ► Integration and accessibility issues can be identified in the earliest design. ► VR technologies are very helpful for assembly and maintenance operation simulations. ► New tools for real time simulations of hands-on operations are currently under development. -- Abstract: In a project like ITER where schedule, resources and cost is continuously optimized, emphasis has to be put on developing long lead items first while keeping other designs very low in definition. Hence, at a particular stage of the project, several components have to coexist in the integrated system while handling different level of maturity. Therefore, all the difficulty consists in managing the interfaces between all these components and to minimize the risk of design changes on the most advanced components. As a future exploitant, ITER is in charge of managing these interfaces and to ensure that maintenance of especially safety important class components (SIC) is feasible. These operation and maintenance constraints have to be taken into account since the earliest design of the components itselves. In this context, CEA IRFM is taking the benefit of using its virtual reality (VR) platform and simulation tools to assist ITER Organization in improving the efficiency of the inconsistencies identification and the machine sub-system design optimization. Currently, two contracts are on-going: the first one concerns the cryostat and in-vessel components; the second one concerns the overall Tokamak (TKM) and diagnostic buildings. This paper describes how VR tools applied to fusion and especially to ITER can help design and Integration with taking into account assembly and maintenance requirements at early stage in the design of complex systems.

  6. ITER design, integration and assembly studies assisted by virtual reality

    International Nuclear Information System (INIS)

    Keller, D.; Doceul, L.; Ferlay, F.; Jiolat, G.; Cordier, J.J.; Kuehn, I.; Manfreo, B.; Reich, J.

    2013-01-01

    Highlights: ► VR technologies applied to Fusion enable to better and faster understand integration issues. ► Problems are solved and validated on a numerical mock up. ► Integration and accessibility issues can be identified in the earliest design. ► VR technologies are very helpful for assembly and maintenance operation simulations. ► New tools for real time simulations of hands-on operations are currently under development. -- Abstract: In a project like ITER where schedule, resources and cost is continuously optimized, emphasis has to be put on developing long lead items first while keeping other designs very low in definition. Hence, at a particular stage of the project, several components have to coexist in the integrated system while handling different level of maturity. Therefore, all the difficulty consists in managing the interfaces between all these components and to minimize the risk of design changes on the most advanced components. As a future exploitant, ITER is in charge of managing these interfaces and to ensure that maintenance of especially safety important class components (SIC) is feasible. These operation and maintenance constraints have to be taken into account since the earliest design of the components itselves. In this context, CEA IRFM is taking the benefit of using its virtual reality (VR) platform and simulation tools to assist ITER Organization in improving the efficiency of the inconsistencies identification and the machine sub-system design optimization. Currently, two contracts are on-going: the first one concerns the cryostat and in-vessel components; the second one concerns the overall Tokamak (TKM) and diagnostic buildings. This paper describes how VR tools applied to fusion and especially to ITER can help design and Integration with taking into account assembly and maintenance requirements at early stage in the design of complex systems

  7. The design of a compact integral medium size PWR

    International Nuclear Information System (INIS)

    Shirvan, Koroush; Hejzlar, Pavel; Kazimi, Mujid S.

    2012-01-01

    Highlights: ► We model the IRIS reactor in RELAP5 and VIPRE codes. ► We use Printed Circuit Heat Exchangers and internally and externally cooled fuel pins in IRIS. ► We increase the IRIS power by 50% and demonstrate adequate safety performance. ► We show significant potential gain in economics for any integral PWR reactor design. - Abstract: Integral reactors have been proposed in recent years as a means to eliminate loss of coolant events, and reduce the number of large vessels of a nuclear power plant. In this paper the focus on how to further increase the power that can be derived from a given vessel volume. The example is applied to the International Reactor Innovative and Secure (IRIS), a medium size, light water reactor rated at 1000 MWt. The IRIS is an integral design containing all pumps and steam generators along with a traditional PWR core inside the reactor vessel. IRIS was designed with 8 Once-Through Helically Coiled Steam Generators (OTHSG), located above the core, in an annular region between the riser and the pressure vessel wall. This work examines ideas to increase its power output in the same vessel size while maintaining or improving the safety margins. The combination of Printed Circuit Heat Exchangers (PCHE) and Internally and EXternally cooled Annular Fuel (IXAF) is proposed to implement such improvement in otherwise the reference IRIS design. Safety implications of such steam generator and fuel design changes for the same reactor size are examined, under both steady state and transients, using the RELAP5 and VIPRE codes. It is found that the IRIS reactor power can be increased by 50% by using the PCHE and IXAF. The proposed design is found to be less expensive per unit electric power produced, these improvements and analyses can be applied to any integral reactor design.

  8. Biomedical data integration in computational drug design and bioinformatics.

    Science.gov (United States)

    Seoane, Jose A; Aguiar-Pulido, Vanessa; Munteanu, Cristian R; Rivero, Daniel; Rabunal, Juan R; Dorado, Julian; Pazos, Alejandro

    2013-03-01

    In recent years, in the post genomic era, more and more data is being generated by biological high throughput technologies, such as proteomics and transcriptomics. This omics data can be very useful, but the real challenge is to analyze all this data, as a whole, after integrating it. Biomedical data integration enables making queries to different, heterogeneous and distributed biomedical data sources. Data integration solutions can be very useful not only in the context of drug design, but also in biomedical information retrieval, clinical diagnosis, system biology, etc. In this review, we analyze the most common approaches to biomedical data integration, such as federated databases, data warehousing, multi-agent systems and semantic technology, as well as the solutions developed using these approaches in the past few years.

  9. Ship Design and Construction. An Integrated University Course

    DEFF Research Database (Denmark)

    Andersen, Poul; Jensen, Jørgen Juncher

    1996-01-01

    This paper describes an integrated course in design and construction of merchant ships taught at the Department of Naval Architecture andOffshore Engineering, the Technical University of Denmark. During the course, the students make a preliminary design of a ship of selected type and also design...... its engine room. The teaching combines lectures with laboratory work at the drawing tables and computer terminals. During the summer holiday, sea time on board ships of the relevant types are offered. Experienced naval architects from shipyards and ship consultancies give lectures and instructions...

  10. NSSS Component Control System Design of Integral Reactor

    International Nuclear Information System (INIS)

    Lee, Joon Koo; Kwon, Ho Je; Jeong, Kwong Il; Park, Heui Youn; Koo, In Soo

    2005-01-01

    MMIS(Man Machine Interface System) of an integral reactor is composed of a Control Room, Plant Protection System, Control System and Monitoring System which are related with the overall plant operation. MMIS is being developed with a new design concept and digital technology to reduce the Human Factor Error and improve the systems' safety, reliability and availability. And CCS(component control system) is also being developed with a new design concept and digital hardware technology A fully digitalized system and design concept are introduced in the NSSS CCS

  11. Preliminary design concepts of an advanced integral reactor

    International Nuclear Information System (INIS)

    Moon, Kap S.; Lee, Doo J.; Kim, Keung K.; Chang, Moon H.; Kim, Si H.

    1997-01-01

    An integral reactor on the basis of PWR technology is being conceptually developed at KAERI. Advanced technologies such as intrinsic and passive safety features are implemented in establishing the design concepts of the reactor to enhance the safety and performance. Research and development including laboratory-scale tests are concurrently underway for confirming the technical adoption of those concepts to the rector design. The power output of the reactor will be in the range of 100MWe to 600MWe which is relatively small compared to the existing loop type reactors. The detailed analysis to assure the design concepts is in progress. (author). 3 figs, 1 tab

  12. Integral Monitored Retrievable Storage (MRS) Facility conceptual design report

    International Nuclear Information System (INIS)

    1985-09-01

    The Basis for Design established the functional requirements and design criteria for an Integral Monitored Retrievable Storage (MRS) facility. The MRS Facility design, described in this report, is based on those requirements and includes all infrastructure, facilities, and equipment required to routinely receive, unload, prepare for storage, and store spent fuel (SF), high-level waste (HLW), and transuranic waste (TRU), and to decontaminate and return shipping casks received by both rail and truck. The facility is complete with all supporting facilities to make the MRS Facility a self-sufficient installation

  13. Analysis and Evaluation of Statistical Models for Integrated Circuits Design

    Directory of Open Access Journals (Sweden)

    Sáenz-Noval J.J.

    2011-10-01

    Full Text Available Statistical models for integrated circuits (IC allow us to estimate the percentage of acceptable devices in the batch before fabrication. Actually, Pelgrom is the statistical model most accepted in the industry; however it was derived from a micrometer technology, which does not guarantee reliability in nanometric manufacturing processes. This work considers three of the most relevant statistical models in the industry and evaluates their limitations and advantages in analog design, so that the designer has a better criterion to make a choice. Moreover, it shows how several statistical models can be used for each one of the stages and design purposes.

  14. Computer-integrated design and information management for nuclear projects

    International Nuclear Information System (INIS)

    Gonzalez, A.; Martin-Guirado, L.; Nebrera, F.

    1987-01-01

    Over the past seven years, Empresarios Agrupados has been developing a comprehensive, computer-integrated system to perform the majority of the engineering, design, procurement and construction management activities in nuclear, fossil-fired as well as hydro power plant projects. This system, which is already in a production environment, comprises a large number of computer programs and data bases designed using a modular approach. Each software module, dedicated to meeting the needs of a particular design group or project discipline, facilitates the performance of functional tasks characteristic of the power plant engineering process

  15. Strategically Integrated Design – Helping Brands to Keep Their Promises

    Directory of Open Access Journals (Sweden)

    Krohn Michael

    2015-11-01

    Full Text Available Many companies incorporate design into their processes much too late and work sequentially instead of in an integrated manner. If, however, the important conceptual, technical or market-relevant decisions have already been made and the product or service is almost ready for launch, then design “cosmetics” will not help much. Design creates images that stick in your mind, and if these images are thought out at the last minute, there’s a risk that they will not optimally promote the overall brand image.

  16. Design Development and Verification of a System Integrated Modular PWR

    International Nuclear Information System (INIS)

    Kim, S.-H.; Kim, K. K.; Chang, M. H.; Kang, C. S.; Park, G.-C.

    2002-01-01

    An advanced PWR with a rated thermal power of 330 MW has been developed at the Korea Atomic Energy Research Institute (KAERI) for a dual purpose: seawater desalination and electricity generation. The conceptual design of SMART ( System-Integrated Modular Advanced ReacTor) with a desalination system was already completed in March of 1999. The basic design for the integrated nuclear desalination system is currently underway and will be finished by March of 2002. The SMART co-generation plant with the MED seawater desalination process is designed to supply forty thousand (40,000) tons of fresh water per day and ninety (90) MW of electricity to an area with approximately a ten thousand (100,000) population or an industrialized complex. This paper describes advanced design features adopted in the SMART design and also introduces the design and engineering verification program. In the beginning stage of the SMART development, top-level requirements for safety and economics were imposed for the SMART design features. To meet the requirements, highly advanced design features enhancing the safety, reliability, performance, and operability are introduced in the SMART design. The SMART consists of proven KOFA (Korea Optimized Fuel Assembly), helical once-through steam generators, a self-controlled pressurizer, control element drive mechanisms, and main coolant pumps in a single pressure vessel. In order to enhance safety characteristics, innovative design features adopted in the SMART system are low core power density, large negative Moderator Temperature Coefficient (MTC), high natural circulation capability and integral arrangement to eliminate large break loss of coolant accident, etc. The progression of emergency situations into accidents is prevented with a number of advanced engineered safety features such as passive residual heat removal system, passive emergency core cooling system, safeguard vessel, and passive containment over-pressure protection. The preliminary

  17. Development of mechanical design technology for integral reactor

    International Nuclear Information System (INIS)

    Park, Keun Bae; Choi, Suhn; Kim, Kang Soo; Kim, Tae Wan; Jeong, Kyeong Hoon; Lee, Gyu Mahn; Kim, Jong Wook; Choi, Woo Seok

    2002-03-01

    This report is the final documentation of the 'Development of Mechanical Design Technology for Integral Reactor' which describes the design activities including reactor vessel assembly structural modelling, normal operation and transient analysis, preparation of design specification, major component stress analysis, evaluation of structural integrity, review of fabricability, maintenance and repair scheme, etc. To establish the design requirements and applicable codes and standards, each GDC criterion was reviewed regarding the SMART structural characteristics and design status, and then the applicability and point of issues were evaluated. To accomodate the result of the core optimization program, modification of pressure vessel and reactor internal components were carried out. SG nozzles were rearranged to penetrate the pressure vessel wall instead of the annular cover. Coolant flow path through the MCP impeller was revised and the adjacent structures were modified. Dynamic analysis model was developed reflecting all the structural changes to perform the seismic and BLPB analysis. Fracture mechanics evaluation on the structural integrity of the reactor pressure vessel was also conducted. Besides, equipment maintenance and replacement plan including the refueling scheme was discussed to confirm the embodiment of SMART through construction and operation

  18. A primer on water

    Science.gov (United States)

    Leopold, Luna Bergere; Langbein, Walter Basil

    1960-01-01

    When you open the faucet you expect water to flow. And you expect it to flow night or day, summer or winter, whether you want to fill a glass or water the lawn. It should be clean and pure, without any odor.You have seen or read about places where the water doesn't have these qualities. You may have lived in a city where you were allowed to water the lawn only during a few hours of certain days. We know a large town where the water turns brown after every big rainstorm.Beginning shortly after World War II, large areas in the Southwestern United States had a 10-year drought, and newspapers published a lot of information about its effects. Some people say that the growing demand for water will cause serious shortages over much of the country in the next 10 to 40 years. But it has always been true that while water wells and springs dry up in some places, floods may be occurring in other places at the same time.Nearly every month news stories are published describing floods somewhere in the country. In fact, every year, on the average, 75,000 persons are forced from their homes by floods. In some years, as in 1951 when the lower Kansas River experienced a great flood, half a million people are affected. To understand the reasons for such recurring distress, it is necessary to know something about rivers and about the flat land or flood plain that borders the river.Interest in water and related problems is growing as our population increases and as the use of water becomes steadily greater. To help meet this heightened interest in general information about water and its use and control is the reason this primer was written. The primer is in two parts. The first part tells about hydrology, or the science that concerns the relation of water to our earth, and the second part describes the development of water supplies and the use of water. The Geological Survey is publishing this primer in nontechnical language in the hope that it will enable the general reader to

  19. Integrated Design Validation: Combining Simulation and Formal Verification for Digital Integrated Circuits

    Directory of Open Access Journals (Sweden)

    Lun Li

    2006-04-01

    Full Text Available The correct design of complex hardware continues to challenge engineers. Bugs in a design that are not uncovered in early design stages can be extremely expensive. Simulation is a predominantly used tool to validate a design in industry. Formal verification overcomes the weakness of exhaustive simulation by applying mathematical methodologies to validate a design. The work described here focuses upon a technique that integrates the best characteristics of both simulation and formal verification methods to provide an effective design validation tool, referred as Integrated Design Validation (IDV. The novelty in this approach consists of three components, circuit complexity analysis, partitioning based on design hierarchy, and coverage analysis. The circuit complexity analyzer and partitioning decompose a large design into sub-components and feed sub-components to different verification and/or simulation tools based upon known existing strengths of modern verification and simulation tools. The coverage analysis unit computes the coverage of design validation and improves the coverage by further partitioning. Various simulation and verification tools comprising IDV are evaluated and an example is used to illustrate the overall validation process. The overall process successfully validates the example to a high coverage rate within a short time. The experimental result shows that our approach is a very promising design validation method.

  20. An Integrated Methodology for Emulsified Formulated Product Design

    DEFF Research Database (Denmark)

    Mattei, Michele

    are mixed together to determine the desired emulsified product. They are still mainly designed and analysed through trial - and - error based exper- imental techniques, therefore a systematic approach , integrating model-based as well a s experiment - based techniques, for design of these products could......The consumer oriented chemical based products are used every day by millions of people. They are structured products constituted of numerous chemicals, and many of them, especially household and personal care products, are emulsions where active ingredients, solvents, additives and surfactants...... significantly reduce both time and cost connected to product development by doing only the necessary experi- ments , and ensuring chances for innovation . The main contribution of this project i s the development of an integrated methodology for the design of emulsified formulated products. The methodology...

  1. Safety design integrated in the Building Delivery System

    DEFF Research Database (Denmark)

    Jørgensen, Kirsten

    2012-01-01

    phases of the building delivery system by using the principle of the lean construction modelling. The method for the research was to go through the lean construction building delivery system step by step and create a normative description of what to do, when to do and how to do to fully integration...... of safety in each process. The group of participants who created the description had a high experience in a combination of research, safety and health in general and especial in construction and knowledge of the lean construction processes both from the clients perspective as well as from the designers...... and the consultants. The result is a concept and guideline including control schemes for how to integrate safety design in the lean construction building delivery system including what to do and when. The concept has been tested in an educational context and found useful by the designers. The practical value...

  2. An integrated computer aided system for integrated design of chemical processes

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Hytoft, Glen; Jaksland, Cecilia

    1997-01-01

    In this paper, an Integrated Computer Aided System (ICAS), which is particularly suitable for solving problems related to integrated design of chemical processes; is presented. ICAS features include a model generator (generation of problem specific models including model simplification and model ...... form the basis for the toolboxes. The available features of ICAS are highlighted through a case study involving the separation of binary azeotropic mixtures. (C) 1997 Elsevier Science Ltd....

  3. Promotion primer. Foerderfibel

    Energy Technology Data Exchange (ETDEWEB)

    1981-01-01

    This revised edition of the promotion primer is to serve as a topical orientation aid for industrial firms, unions, boards and other bodies interested where the actions of governmental R and D and innovation policy are compiled and clearly arranged. It is important for the success of governmental aids that the institutions concerned are informed about all possibilities of the promotion, financing and advisory programme. Beyond the presentation of the research promotion sectors, the fiscal measures and the contractual as well as the joint research this revised edition focussess on the fields of consultative services for innovation and information. For many firms the access to qualified information and guidance is of particular importance. That is why this brochure points out the ways towards governmental research promotion. The BMFT has provided a remarkable contribution to research promotion by establishing information and consultative services for trade and industry.

  4. Metabolomics: A Primer.

    Science.gov (United States)

    Liu, Xiaojing; Locasale, Jason W

    2017-04-01

    Metabolomics generates a profile of small molecules that are derived from cellular metabolism and can directly reflect the outcome of complex networks of biochemical reactions, thus providing insights into multiple aspects of cellular physiology. Technological advances have enabled rapid and increasingly expansive data acquisition with samples as small as single cells; however, substantial challenges in the field remain. In this primer we provide an overview of metabolomics, especially mass spectrometry (MS)-based metabolomics, which uses liquid chromatography (LC) for separation, and discuss its utilities and limitations. We identify and discuss several areas at the frontier of metabolomics. Our goal is to give the reader a sense of what might be accomplished when conducting a metabolomics experiment, now and in the near future. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. A Brief Taxometrics Primer

    Science.gov (United States)

    Beauchaine, Theodore P.

    2009-01-01

    Taxometric procedures provide an empirical means of determining which psychiatric disorders are typologically distinct from normal behavioral functioning. Although most disorders reflect extremes along continuously distributed behavioral traits, identifying those that are discrete has important implications for accurate diagnosis, effective treatment, early identification of risk, and improved understanding of etiology. This article provides (a) brief descriptions of the conceptual bases of several taxometric procedures, (b) example analyses using simulated data, and (c) strategies for avoiding common pitfalls that are often observed in taxometrics research. To date, most taxometrics studies have appeared in the adult psychopathology literature. It is hoped that this primer will encourage interested readers to extend taxometrics research to child and adolescent populations. PMID:18088222

  6. New ways of integrating material knowledge into the design process

    DEFF Research Database (Denmark)

    Højris, Anders; Nielsen, Louise Møller

    2013-01-01

    – based on technical performance, no longer apply. Accordingly the approach in this paper is to view information and knowledge about materials through the perspective of organizational memory and technology brokering. This paper is build upon two cases from the German based design studio: designaffairs...... libraries and thereby access to information on new material possibilities has also changed the way designers integrate knowledge about materials into the design process. This means that the traditional design process model, where the selection of materials takes place after the design of form and function...... in order to help clients to find the right material among hundreds of samples. Furthermore a number of material libraries have also been developed into online database, which provides detailed information about new material and makes the information accessible from almost everywhere. The access to material...

  7. Argentinean integrated small reactor design and scale economy analysis of integrated reactor

    International Nuclear Information System (INIS)

    Florido, P. C.; Bergallo, J. E.; Ishida, M. V.

    2000-01-01

    This paper describes the design of CAREM, which is Argentinean integrated small reactor project and the scale economy analysis results of integrated reactor. CAREM project consists on the development, design and construction of a small nuclear power plant. CAREM is an advanced reactor conceived with new generation design solutions and standing on the large experience accumulated in the safe operation of Light Water Reactors. The CAREM is an indirect cycle reactor with some distinctive and characteristic features that greatly simplify the reactor and also contribute to a highly level of safety: integrated primary cooling system, self pressurized, primary cooling by natural circulation and safety system relying on passive features. For a fully doupled economic evaluation of integrated reactors done by IREP (Integrated Reactor Evaluation Program) code transferred to IAEA, CAREM have been used as a reference point. The results shows that integrated reactors become competitive with power larger than 200MWe with Argentinean cheapest electricity option. Due to reactor pressure vessel construction limit, low pressure drop steam generator are used to reach power output of 200MWe for natural circulation. For forced circulation, 300MWe can be achieved. (author)

  8. Sustainable Design Re-Examined: Integrated Approach to Knowledge Creation for Sustainable Interior Design

    Science.gov (United States)

    Lee, Young S.

    2014-01-01

    The article focuses on a systematic approach to the instructional framework to incorporate three aspects of sustainable design. It also aims to provide an instruction model for sustainable design stressing a collective effort to advance knowledge creation as a community. It develops a framework conjoining the concept of integrated process in…

  9. Criticality calculations with MCNP trademark: A primer

    International Nuclear Information System (INIS)

    Harmon, C.D. II; Busch, R.D.; Briesmeister, J.F.; Forster, R.A.

    1994-01-01

    With the closure of many experimental facilities, the nuclear criticality safety analyst increasingly is required to rely on computer calculations to identify safe limits for the handling and storage of fissile materials. However, in many cases, the analyst has little experience with the specific codes available at his/her facility. This primer will help you, the analyst, understand and use the MCNP Monte Carlo code for nuclear criticality safety analyses. It assumes that you have a college education in a technical field. There is no assumption of familiarity with Monte Carlo codes in general or with MCNP in particular. Appendix A gives an introduction to Monte Carlo techniques. The primer is designed to teach by example, with each example illustrating two or three features of MCNP that are useful in criticality analyses. Beginning with a Quickstart chapter, the primer gives an overview of the basic requirements for MCNP input and allows you to run a simple criticality problem with MCNP. This chapter is not designed to explain either the input or the MCNP options in detail; but rather it introduces basic concepts that are further explained in following chapters. Each chapter begins with a list of basic objectives that identify the goal of the chapter, and a list of the individual MCNP features that are covered in detail in the unique chapter example problems. It is expected that on completion of the primer you will be comfortable using MCNP in criticality calculations and will be capable of handling 80 to 90 percent of the situations that normally arise in a facility. The primer provides a set of basic input files that you can selectively modify to fit the particular problem at hand

  10. Design optimization of radiation-hardened CMOS integrated circuits

    International Nuclear Information System (INIS)

    1975-01-01

    Ionizing-radiation-induced threshold voltage shifts in CMOS integrated circuits will drastically degrade circuit performance unless the design parameters related to the fabrication process are properly chosen. To formulate an approach to CMOS design optimization, experimentally observed analytical relationships showing strong dependences between threshold voltage shifts and silicon dioxide thickness are utilized. These measurements were made using radiation-hardened aluminum-gate CMOS inverter circuits and have been corroborated by independent data taken from MOS capacitor structures. Knowledge of these relationships allows one to define ranges of acceptable CMOS design parameters based upon radiation-hardening capabilities and post-irradiation performance specifications. Furthermore, they permit actual design optimization of CMOS integrated circuits which results in optimum pre- and post-irradiation performance with respect to speed, noise margins, and quiescent power consumption. Theoretical and experimental results of these procedures, the applications of which can mean the difference between failure and success of a CMOS integrated circuit in a radiation environment, are presented

  11. Lightweight structure design for wind energy by integrating nanostructured materials

    International Nuclear Information System (INIS)

    Li, Ying; Lu, Jian

    2014-01-01

    Highlights: • Integrate high-strength nano-materials into lightweight design. • Lightweight design scheme for wind turbine tower application. • Expand the bending formulae for tapered tubular structures with varying thickness. • We rewrite the Secant Formula for a tapered beam under eccentric compression. - Abstract: Wind power develops very fast nowadays with high expectation. Although at the mean time, the use of taller towers, however, smacks head-on into the issue of transportability. The engineering base and computational tools have to be developed to match machine size and volume. Consequently the research on the light weight structures of tower is carrying out in the main countries which are actively developing wind energy. This paper reports a new design scheme of light weight structure for wind turbine tower. This design scheme is based on the integration of the nanostructured materials produced by the Surface Mechanical Attrition Treatment (SMAT) process. The objective of this study is to accomplish the weight reduction by optimizing the wall thickness of the tapered tubular structure. The basic methods include the identification of the critical zones and the distribution of the high strength materials according to different necessities. The equivalent strength or stiffness design method and the high strength material properties after SMAT process are combined together. Bending and buckling are two main kinds of static loads concerned in consideration. The study results reveal that there is still enough margin for weight reduction in the traditional wind turbine tower design

  12. Integrated design optimization research and development in an industrial environment

    Science.gov (United States)

    Kumar, V.; German, Marjorie D.; Lee, S.-J.

    1989-01-01

    An overview is given of a design optimization project that is in progress at the GE Research and Development Center for the past few years. The objective of this project is to develop a methodology and a software system for design automation and optimization of structural/mechanical components and systems. The effort focuses on research and development issues and also on optimization applications that can be related to real-life industrial design problems. The overall technical approach is based on integration of numerical optimization techniques, finite element methods, CAE and software engineering, and artificial intelligence/expert systems (AI/ES) concepts. The role of each of these engineering technologies in the development of a unified design methodology is illustrated. A software system DESIGN-OPT has been developed for both size and shape optimization of structural components subjected to static as well as dynamic loadings. By integrating this software with an automatic mesh generator, a geometric modeler and an attribute specification computer code, a software module SHAPE-OPT has been developed for shape optimization. Details of these software packages together with their applications to some 2- and 3-dimensional design problems are described.

  13. Bringing service design to manufacturing companies: integrating PSS and service design approaches

    DEFF Research Database (Denmark)

    Costa, Nina; Patrício, Lia; Morelli, Nicola

    2018-01-01

    in a manufacturing industry. This paper details how the application supports the design of product–service system solutions from the exploration to the implementation stages, highlighting the physical evidence of service, and contributes to advance design research at the intersection of PSS and Service Design.......Manufacturing companies increasingly try to innovate in their offers to consumers by creating more complete solutions that combine product and service components. However, shifting from a product-centric perspective to a solution-oriented perspective is challenging. The present study adopted...... a design research methodology and built on Service-Dominant logic, integrating the human-oriented perspective of Service Design with an organizational network-oriented perspective of Product–Service System. It creates a new Integrative PSS approach, evolves design models, and provides an application...

  14. Design Integration - a theroretical and empirical study of design integration in small and medium sized Danish companies

    DEFF Research Database (Denmark)

    Erichsen, Pia Geisby

    er drivkræft. Afhandlingen bidrager til design management feltet med en ny måde at tale om og forstå design integration. Yderligere bidrager den med ny viden omkring dynamikken omkring design integration. Sidst men ikke mindst biddrager den til, at designledelseskonsulenter samt små og mellemstore...... organisatorisk kontekst?’ - blev søgt besvaret gennem to litteraturstudier af henholdsvis design management og design. Litteraturstudiet af design management gav imidlertid kun begrænsede svar på spørgsmålet ’hvad er design?’. Designfeltet derimod kunne give et mere nuanceret svar, hvilket resulterede i en ny...... blev det identificeret, at det var relevant, at se på barrierer og drivkræfter et dynamisk perspektiv. Via observationsstudiet blev designtrappen identificeret som relevant i forhold til forskningsspørgsmålet, men modellen havde også nogle indbyggede barrierer, hvorfor der blev søgt efter andre...

  15. Concise Review: Organ Engineering: Design, Technology, and Integration.

    Science.gov (United States)

    Kaushik, Gaurav; Leijten, Jeroen; Khademhosseini, Ali

    2017-01-01

    Engineering complex tissues and whole organs has the potential to dramatically impact translational medicine in several avenues. Organ engineering is a discipline that integrates biological knowledge of embryological development, anatomy, physiology, and cellular interactions with enabling technologies including biocompatible biomaterials and biofabrication platforms such as three-dimensional bioprinting. When engineering complex tissues and organs, core design principles must be taken into account, such as the structure-function relationship, biochemical signaling, mechanics, gradients, and spatial constraints. Technological advances in biomaterials, biofabrication, and biomedical imaging allow for in vitro control of these factors to recreate in vivo phenomena. Finally, organ engineering emerges as an integration of biological design and technical rigor. An overall workflow for organ engineering and guiding technology to advance biology as well as a perspective on necessary future iterations in the field is discussed. Stem Cells 2017;35:51-60. © 2016 AlphaMed Press.

  16. Computer graphics application in the engineering design integration system

    Science.gov (United States)

    Glatt, C. R.; Abel, R. W.; Hirsch, G. N.; Alford, G. E.; Colquitt, W. N.; Stewart, W. A.

    1975-01-01

    The computer graphics aspect of the Engineering Design Integration (EDIN) system and its application to design problems were discussed. Three basic types of computer graphics may be used with the EDIN system for the evaluation of aerospace vehicles preliminary designs: offline graphics systems using vellum-inking or photographic processes, online graphics systems characterized by direct coupled low cost storage tube terminals with limited interactive capabilities, and a minicomputer based refresh terminal offering highly interactive capabilities. The offline line systems are characterized by high quality (resolution better than 0.254 mm) and slow turnaround (one to four days). The online systems are characterized by low cost, instant visualization of the computer results, slow line speed (300 BAUD), poor hard copy, and the early limitations on vector graphic input capabilities. The recent acquisition of the Adage 330 Graphic Display system has greatly enhanced the potential for interactive computer aided design.

  17. Integrating chemical engineering fundamentals in the capstone process design project

    DEFF Research Database (Denmark)

    von Solms, Nicolas; Woodley, John; Johnsson, Jan Erik

    2010-01-01

    Reaction Engineering. In order to incorporate reactor design into process design in a meaningful way, the teachers of the respective courses need to collaborate (Standard 9 – Enhancement of Faculty CDIO skills). The students also see that different components of the chemical engineering curriculum relate......All B.Eng. courses offered at the Technical University of Denmark (DTU) must now follow CDIO standards. The final “capstone” course in the B.Eng. education is Process Design, which for many years has been typical of chemical engineering curricula worldwide. The course at DTU typically has about 30...... of the CDIO standards – especially standard 3 – Integrated Curriculum - means that the course projects must draw on competences provided in other subjects which the students are taking in parallel with Process Design – specifically Process Control and Reaction Engineering. In each semester of the B...

  18. Integrated Human Factors Design Guidelines for Sound Interface

    International Nuclear Information System (INIS)

    Lee, Jung Woon; Lee, Yong Hee; Oh, In Seok; Lee, Hyun Chul; Cha, Woo Chang

    2004-05-01

    Digital MMI, such as CRT, LCD etc., has been used increasingly in the design of main control room of the Korean standard nuclear power plants following the YGN units 3 and 4. The utilization of digital MMI may introduce various kind of sound interface into the control room design. In this project, for five top-level guideline items, including Sound Formats, Alarms, Sound Controls, Communications, and Environments, a total of 147 detail guidelines were developed and a database system for these guidelines was developed. The integrated human factors design guidelines for sound interface and the database system developed in this project will be useful for the design of sound interface of digital MMI in Korean NPPs

  19. Integrated Human Factors Design Guidelines for Sound Interface

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jung Woon; Lee, Yong Hee; Oh, In Seok; Lee, Hyun Chul [KAERI, Daejeon (Korea, Republic of); Cha, Woo Chang [Kumoh National Univ. of Technology, Gumi (Korea, Republic of)

    2004-05-15

    Digital MMI, such as CRT, LCD etc., has been used increasingly in the design of main control room of the Korean standard nuclear power plants following the YGN units 3 and 4. The utilization of digital MMI may introduce various kind of sound interface into the control room design. In this project, for five top-level guideline items, including Sound Formats, Alarms, Sound Controls, Communications, and Environments, a total of 147 detail guidelines were developed and a database system for these guidelines was developed. The integrated human factors design guidelines for sound interface and the database system developed in this project will be useful for the design of sound interface of digital MMI in Korean NPPs.

  20. Trends in integrated circuit design for particle physics experiments

    International Nuclear Information System (INIS)

    Atkin, E V

    2017-01-01

    Integrated circuits are one of the key complex units available to designers of multichannel detector setups. A whole number of factors makes Application Specific Integrated Circuits (ASICs) valuable for Particle Physics and Astrophysics experiments. Among them the most important ones are: integration scale, low power dissipation, radiation tolerance. In order to make possible future experiments in the intensity, cosmic, and energy frontiers today ASICs should provide new level of functionality at a new set of constraints and trade-offs, like low-noise high-dynamic range amplification and pulse shaping, high-speed waveform sampling, low power digitization, fast digital data processing, serialization and data transmission. All integrated circuits, necessary for physical instrumentation, should be radiation tolerant at an earlier not reached level (hundreds of Mrad) of total ionizing dose and allow minute almost 3D assemblies. The paper is based on literary source analysis and presents an overview of the state of the art and trends in nowadays chip design, using partially own ASIC lab experience. That shows a next stage of ising micro- and nanoelectronics in physical instrumentation. (paper)

  1. Integrated design approach of the pebble bed modular using models

    International Nuclear Information System (INIS)

    Venter, P.J.

    2005-01-01

    The Pebble Bed Modular Reactor (PBMR) is the first pebble bed reactor that will be utilised in a high temperature direct Brayton cycle configuration. This implies that there are a number of unique features in the PBMR that extend from the German experience base. One of the challenges in the design of the PBMR is managing the integrated design process between the designers, the physicists and the analysts. This integrated design process is managed through model-based development work. Three-dimensional CAD models are constructed of the components and parts in the reactor. From the CAD models, CFD models, neutronic models, shielding models, FEM models and other thermodynamic models are derived. These models range from very simple models to extremely detailed and complex models. The models are used in legacy software as well as commercial off-the-shelf software. The different models are also used in code-to-code comparisons to verify the results. This paper will briefly discuss the different models and the interaction between the models, showing the iterative design process that is used in the development of the reactor at PBMR. (author)

  2. DESIGN ANALYSIS OF ELECTRICAL MACHINES THROUGH INTEGRATED NUMERICAL APPROACH

    Directory of Open Access Journals (Sweden)

    ARAVIND C.V.

    2016-02-01

    Full Text Available An integrated design platform for the newer type of machines is presented in this work. The machine parameters are evaluated out using developed modelling tool. With the machine parameters, the machine is modelled using computer aided tool. The designed machine is brought to simulation tool to perform electromagnetic and electromechanical analysis. In the simulation, conditions setting are performed to setup the materials, meshes, rotational speed and the excitation circuit. Electromagnetic analysis is carried out to predict the behavior of the machine based on the movement of flux in the machines. Besides, electromechanical analysis is carried out to analyse the speed-torque characteristic, the current-torque characteristic and the phase angle-torque characteristic. After all the results are analysed, the designed machine is used to generate S block function that is compatible with MATLAB/SIMULINK tool for the dynamic operational characteristics. This allows the integration of existing drive system into the new machines designed in the modelling tool. An example of the machine design is presented to validate the usage of such a tool.

  3. Supplier integration for new product developments: antecedents for supplier integration in modular product designs

    NARCIS (Netherlands)

    Eggers, Justus Erich

    2016-01-01

    Original equipment manufacturers (OEMs) increasingly integrate supplier resources in new product developments (NPD) to overcome bottlenecks of resource and to create competitive advantages. At the same time, OEMs react to the new market challenges by implementing modular product designs. Despite the

  4. Integration of distributed system simulation tools for a holistic approach to integrated building and system design

    NARCIS (Netherlands)

    Radosevic, M.; Hensen, J.L.M.; Wijsman, A.J.T.M.; Hensen, J.L.M.; Lain, M.

    2004-01-01

    Advanced architectural developments require an integrated approach to design where simulation tools available today deal. only with a small subset of the overall problem. The aim of this study is to enable run time exchange of necessary data at suitable frequency between different simulation

  5. The design features of integrated modular water reactor (IMR)

    International Nuclear Information System (INIS)

    Kanagawa, T.; Goto, M.; Usui, S.; Suzuta, T.; Serizawa, A.; Kunugi, T.; Yamauchi, T.; Itoh, G.; Matsumura, T.

    2004-01-01

    Small-to-medium-sized (300-600 MWe) reactors are required for the electric power market in the near future (2010-2030). The main theme in the development of small-to-medium-sized reactor is how to realize competitive cost against other energy sources. As measures to this disadvantage, greatly simplified and small-scale design is needed. From such point of view, Integrated Modular Water Reactor (IMR), whose electric output power is 350 MWe, adopts integrated and high temperature two-phase natural circulation system for the primary system. In this design, main coolant pipes, a pressurizer, and reactor coolant pumps are not needed, and the sizes of the reactor vessel and steam generators are minimized. Additionally, to enhance the economy of the whole plant, fluid systems, and Instrumentation and Control systems of IMR have also been reviewed to make them simplest and smallest taking the advantage of the IMR concept and the state of the art technologies. For example, the integrated primary system and the stand-alone direct heat removal system make the safety system very simple, i.e., no injection, no containment spray, no emergency AC power, etc. The chemical and volume control system is also simplified by eliminating the boron control system and the seal water system of reactor coolant pumps. In this paper, the status of the IMR development and the outline of the IMR design efforts to achieve the simplest and smallest plant are presented. (authors)

  6. Safeguards-by-Design: An Element of 3S Integration

    International Nuclear Information System (INIS)

    Bean, R.S.; Bjornard, T.A.; Hebdich, D.J.

    2009-01-01

    In 2008, the '20/20 Vision for the Future' background report by the IAEA Director General identified the possibility of integrating certain activities related to safeguards, safety, and security. Later in the year, the independent Commission report prepared at the request of the IAEA Director General noted that the Agency's's roles in nuclear safeguards, safety, and security (3S) complement and can mutually reinforce each other. Safeguards-by-design (SBD) is a practical measure that strengthens 3S integration, especially for the stage of nuclear facility design and construction, but also with ramifications for other stages of the facility life-cycle. This paper describes the SBD concept, with examples for diverse regulatory environments, being developed in the U.S under the U.S. Department of Energy (DOE) Next Generation Safeguards Initiative and the Advanced Fuel Cycle Initiative. This is compared with related international SBD work performed in the recent IAEA workshop on 'Facility Design and Plant Operation Features that Facilitate the Implementation of IAEA Safeguards'. Potential future directions for further development of SBD and its integration within 3S are identified.

  7. Designing to target cost: one approach to design/construction integration

    DEFF Research Database (Denmark)

    Jørgensen, Bo

    2005-01-01

    One approach to a more integrated construction delivery process is the concept of ‘designing to target cost’ of which the first examples of application within a lean construction framework have recently been seen. This paper introduces the main principles of the design to target cost method...... and discusses the applicability of this approach to construction. The low degree of organizational and technical continuity from one construction project to the next limits the applicability of the design for target cost approach when compared to its origin in product development of mass manufactured artefacts....... It can be argued that design to target cost may also provide a frame for developing the supply chain towards better coordination and collaboration. Thus methods of design to target cost may serve to facilitate the development of a more integrated supply chain....

  8. Examining the process of de novo gene birth: an educational primer on "integration of new genes into cellular networks, and their structural maturation".

    Science.gov (United States)

    Frietze, Seth; Leatherman, Judith

    2014-03-01

    New genes that arise from modification of the noncoding portion of a genome rather than being duplicated from parent genes are called de novo genes. These genes, identified by their brief evolution and lack of parent genes, provide an opportunity to study the timeframe in which emerging genes integrate into cellular networks, and how the characteristics of these genes change as they mature into bona fide genes. An article by G. Abrusán provides an opportunity to introduce students to fundamental concepts in evolutionary and comparative genetics and to provide a technical background by which to discuss systems biology approaches when studying the evolutionary process of gene birth. Basic background needed to understand the Abrusán study and details on comparative genomic concepts tailored for a classroom discussion are provided, including discussion questions and a supplemental exercise on navigating a genome database.

  9. Operative integration to the first collective agreement 1998-2003; De la Integracion operativa al primer convenio colectivo 1998-2003

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    The article describes the process followed from the time of Operational Integration of the two AIEs-ANA and CNV II-which operated the Asco-I and II and Vandellos-II nuclear power plants, and and the merger of these two ventures up to the signing of a single Collective Agreement that, in the framework of labor-relations, allowed for a process of consolidation that gave rise to unified corporate regulation and planning of human resources. In 1998 , the year in which the process began, there were two companies-ANA and CNV II-with two Collective Agreements, two Pension Plans and two Corporate Headquarters located in Barcelona. Now there is only one company-ANAV-with a single Collective Agreement a single Pension Plan with two sub-plans, and generational changeover in its final phase with the target staff and no excess. (Author)

  10. Radiation protection primer

    International Nuclear Information System (INIS)

    Aigner, R.; Melzer, E.; Seissler, H.

    1986-01-01

    This 'radiation protection primer' does not pretend to give absolute, final answers to the many questions that have been arising after the Chernobyl accident. What it is intended to supply, as a schematic overview of problems resulting from nuclear accidents, and a likewise systematic outline of possible solutions and sensible reactions to such an event. The book takes up questions such as: What has happened to the soil. Will future harvests be 'clean' again. What does radioactivity to our drinking water and other waters. What are the effects of a radioactive fallout on food. What may we eat or drink. What happens to the human body after intake of radioactive air, or - even only slightly - contaminated food or water. What can we do to protect our health, and the health of our children. Is there anything else we can do in order to avoid such a disaster in future, except from shutting-off all reactors. The book itself presents some answers and advice, along with a list of terms and explanations, and addresses to apply to for further advice and information. (orig./HP) [de

  11. Primers for phylogeny reconstruction in Bignonieae (Bignoniaceae) using herbarium samples.

    Science.gov (United States)

    Zuntini, Alexandre R; Fonseca, Luiz Henrique M; Lohmann, Lúcia G

    2013-09-01

    New primers were developed for Bignonieae to enable phylogenetic studies within this clade using herbarium samples. • Internal primers were designed based on available sequences of the plastid ndhF gene and the rpl32-trnL intergenic spacer region, and the nuclear gene PepC. The resulting primers were used to amplify DNA extracted from herbarium materials. High-quality data were obtained from herbarium samples up to 53 yr old. • The standardized methodology allows the inclusion of herbarium materials as alternative sources of DNA for phylogenetic studies in Bignonieae.

  12. Primers for Phylogeny Reconstruction in Bignonieae (Bignoniaceae Using Herbarium Samples

    Directory of Open Access Journals (Sweden)

    Alexandre R. Zuntini

    2013-08-01

    Full Text Available Premise of the study: New primers were developed for Bignonieae to enable phylogenetic studies within this clade using herbarium samples. Methods and Results: Internal primers were designed based on available sequences of the plastid ndhF gene and the rpl32-trnL intergenic spacer region, and the nuclear gene PepC. The resulting primers were used to amplify DNA extracted from herbarium materials. High-quality data were obtained from herbarium samples up to 53 yr old. Conclusions: The standardized methodology allows the inclusion of herbarium materials as alternative sources of DNA for phylogenetic studies in Bignonieae.

  13. Stochastic simulation and robust design optimization of integrated photonic filters

    Directory of Open Access Journals (Sweden)

    Weng Tsui-Wei

    2016-07-01

    Full Text Available Manufacturing variations are becoming an unavoidable issue in modern fabrication processes; therefore, it is crucial to be able to include stochastic uncertainties in the design phase. In this paper, integrated photonic coupled ring resonator filters are considered as an example of significant interest. The sparsity structure in photonic circuits is exploited to construct a sparse combined generalized polynomial chaos model, which is then used to analyze related statistics and perform robust design optimization. Simulation results show that the optimized circuits are more robust to fabrication process variations and achieve a reduction of 11%–35% in the mean square errors of the 3 dB bandwidth compared to unoptimized nominal designs.

  14. Integrating Emotional Attachment and Sustainability in Electronic Product Design

    Directory of Open Access Journals (Sweden)

    Alex Lobos

    2013-03-01

    Full Text Available Current models for Information and Communication Technology (ICT products encourage frequent product replacement with newer versions that offer only minor incremental improvements. This pattern, named planned obsolescence, diminishes user experience and shortens product lifespan. This paper presents the conceptual basis for a two-part integrated approach to combating planned obsolescence in ICT devices. First, design for emotional attachment, which creates products that users enjoy, value, and use for longer. Second, technological adaptability, which anticipates product upgrades and repairs as new technologies emerge. A model interdisciplinary design course in industrial design and sustainability, also described herein, trains students to apply this approach to create innovative ICT products with smaller environmental footprints.

  15. How can design approaches be integrated into entrepreneurship education?

    DEFF Research Database (Denmark)

    Færgemann, Helle Meibom; Nørgård, Rikke Toft; Robinson, Sarah

    reflection about the intention and how the elements fit with the entrepreneurship field. The proposed process model presented (Fig 3) primarily has potential to strengthen the awareness of the need to alternate between divergence and convergence many times through an entrepreneurial process. Apart from......Questions we care about: When educating students through entrepreneurship we are interested in how can design approaches and processes be integrated into Entrepreneurship Education and what effect does this have on entrepreneurial learning? Approach: This is a conceptual paper which draws on data...... from a classic entrepreneurship course (mix of for- and through-approach) as well as a classic design course. Furthermore data from the iterative development of an entrepreneurship course with substantial design elements is a key data source. Overall, products and processes in the course have been...

  16. Software features and applications in process design, integration and operation

    Energy Technology Data Exchange (ETDEWEB)

    Dhole, V. [Aspen Tech Limited, Warrington (United Kingdom)

    1999-02-01

    Process engineering technologies and tools have evolved rapidly over the last twenty years. Process simulation/modeling, advanced process control, on-line optimisation, production planning and supply chain management are some of the examples of technologies that have rapidly matured from early commercial prototypes and concepts to established tools with significant impact on profitability of process industry today. Process Synthesis or Process Integration (PI) in comparison is yet to create its impact and still remains largely in the domain of few expert users. One of the key reasons as to why PI has not taken off is because the PI tools have not become integral components of the standard process engineering environments. On the last 15 years AspenTech has grown from a small process simulation tool provider to a large multinational company providing a complete suite of process engineering technologies and services covering process design, operation, planning and supply chain management. Throughout this period, AspenTech has acquired experience in rapidly evolving technologies from their early prototype stage to mature products and services. The paper outlines AspenTech`s strategy of integrating PI with other more established process design and operational improvement technologies. The paper illustrates the key elements of AspenTech`s strategy via examples of software development initiatives and services projects. The paper also outlines AspenTech`s future vision of the role of PI in process engineering. (au)

  17. Development of fluid system design technology for integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lee, D. J.; Chang, M. H.; Kang, D. J. and others

    1999-03-01

    This study presents the technology development of the system design concepts of SMART, a multi-purposed integral reactor with enhanced safety and operability, for use in diverse usages and applications of the nuclear energy. This report contains the following; - Design characteristics - Performance and safety related design criteria - System description: Primary system, Secondary system, Residual heat removal system, Make-up system, Component cooling system, Safety system - Development of design computer code: Steam generator performance(ONCESG), Pressurizer performance(COLDPZR), Steam generator flow instability(SGINS) - Development of component module and modeling using MMS computer code - Design calculation: Steam generator thermal sizing, Analysis of feed-water temperature increase at a low flow rate, Evaluation of thermal efficiency in the secondary system, Inlet orifice throttling coefficient for the prevention of steam generator flow instability, Analysis of Nitrogen gas temperature in the pressurizer during heat-up process, evaluation of water chemistry and erosion etc. The results of this study can be utilized not only for the foundation technology of the next phase basic system design of the SMART but also for the basic model in optimizing the system concepts for future advanced reactors. (author)

  18. Accurate Complex Systems Design: Integrating Serious Games with Petri Nets

    Directory of Open Access Journals (Sweden)

    Kirsten Sinclair

    2016-03-01

    Full Text Available Difficulty understanding the large number of interactions involved in complex systems makes their successful engineering a problem. Petri Nets are one graphical modelling technique used to describe and check proposed designs of complex systems thoroughly. While automatic analysis capabilities of Petri Nets are useful, their visual form is less so, particularly for communicating the design they represent. In engineering projects, this can lead to a gap in communications between people with different areas of expertise, negatively impacting achieving accurate designs.In contrast, although capable of representing a variety of real and imaginary objects effectively, behaviour of serious games can only be analysed manually through interactive simulation. This paper examines combining the complementary strengths of Petri Nets and serious games. The novel contribution of this work is a serious game prototype of a complex system design that has been checked thoroughly. Underpinned by Petri Net analysis, the serious game can be used as a high-level interface to communicate and refine the design.Improvement of a complex system design is demonstrated by applying the integration to a proof-of-concept case study.   

  19. Social research design: framework for integrating philosophical and practical elements.

    Science.gov (United States)

    Cunningham, Kathryn Burns

    2014-09-01

    To provide and elucidate a comprehensible framework for the design of social research. An abundance of information exists concerning the process of designing social research. The overall message that can be gleaned is that numerable elements - both philosophical (ontological and epistemological assumptions and theoretical perspective) and practical (issue to be addressed, purpose, aims and research questions) - are influential in the process of selecting a research methodology and methods, and that these elements and their inter-relationships must be considered and explicated to ensure a coherent research design that enables well-founded and meaningful conclusions. There is a lack of guidance concerning the integration of practical and philosophical elements, hindering their consideration and explication. The author's PhD research into loneliness and cancer. This is a methodology paper. A guiding framework that incorporates all of the philosophical and practical elements influential in social research design is presented. The chronological and informative relationships between the elements are discussed. The framework presented can be used by social researchers to consider and explicate the practical and philosophical elements influential in the selection of a methodology and methods. It is hoped that the framework presented will aid social researchers with the design and the explication of the design of their research, thereby enhancing the credibility of their projects and enabling their research to establish well-founded and meaningful conclusions.

  20. Designing neutral-atom nanotraps with integrated optical waveguides

    International Nuclear Information System (INIS)

    Burke, James P. Jr.; Chu, S.-T.; Bryant, Garnett W.; Williams, C.J.; Julienne, P.S.

    2002-01-01

    Integrated optical structures offer the intriguing potential of compact, reproducible waveguide arrays, rings, Y junctions, etc., that could be used to design evanescent field traps to transport, store, and interact atoms in networks as complicated as any integrated optical waveguide circuit. We theoretically investigate three approaches to trapping atoms above linear integrated optical waveguides. A two-color scheme balances the decaying evanescent fields of red- and blue-detuned light to produce a potential minimum above the guide. A one-color surface trap proposal uses blue-detuned light and the attractive surface interaction to provide a potential minimum. A third proposal uses blue-detuned light in two guides positioned above and below one another. The atoms are confined to the 'dark' spot in the vacuum gap between the guides. We find that all three approaches can be used to trap atoms in two or three dimensions with approximately 100 mW of laser power. We show that the dark spot guide is robust to light scatter and provides the most viable approach for constructing integrated optical circuits that could be used to transport and manipulate atoms in a controlled manner

  1. Design automation for integrated nonlinear logic circuits (Conference Presentation)

    Science.gov (United States)

    Van Vaerenbergh, Thomas; Pelc, Jason; Santori, Charles; Bose, Ranojoy; Kielpinski, Dave; Beausoleil, Raymond G.

    2016-05-01

    A key enabler of the IT revolution of the late 20th century was the development of electronic design automation (EDA) tools allowing engineers to manage the complexity of electronic circuits with transistor counts now reaching into the billions. Recently, we have been developing large-scale nonlinear photonic integrated logic circuits for next generation all-optical information processing. At this time a sufficiently powerful EDA-style software tool chain to design this type of complex circuits does not yet exist. Here we describe a hierarchical approach to automating the design and validation of photonic integrated circuits, which can scale to several orders of magnitude higher complexity than the state of the art. Most photonic integrated circuits developed today consist of a small number of components, and only limited hierarchy. For example, a simple photonic transceiver may contain on the order of 10 building-block components, consisting of grating couplers for photonic I/O, modulators, and signal splitters/combiners. Because this is relatively easy to lay out by hand (or simple script) existing photonic design tools have relatively little automation in comparison to electronics tools. But demonstrating all-optical logic will require significantly more complex photonic circuits containing up to 1,000 components, hence becoming infeasible to design manually. Our design framework is based off Python-based software from Luceda Photonics which provides an environment to describe components, simulate their behavior, and export design files (GDS) to foundries for fabrication. At a fundamental level, a photonic component is described as a parametric cell (PCell) similarly to electronics design. PCells are described by geometric characteristics of their layout. A critical part of the design framework is the implementation of PCells as Python objects. PCell objects can then use inheritance to simplify design, and hierarchical designs can be made by creating composite

  2. Multi-disciplinary coupling for integrated design of propulsion systems

    Science.gov (United States)

    Chamis, C. C.; Singhal, S. N.

    1993-01-01

    Effective computational simulation procedures are described for modeling the inherent multi-disciplinary interactions for determining the true response of propulsion systems. Results are presented for propulsion system responses including multi-discipline coupling effects via (1) coupled multi-discipline tailoring, (2) an integrated system of multidisciplinary simulators, (3) coupled material-behavior/fabrication-process tailoring, (4) sensitivities using a probabilistic simulator, and (5) coupled materials/structures/fracture/probabilistic behavior simulator. The results show that the best designs can be determined if the analysis/tailoring methods account for the multi-disciplinary coupling effects. The coupling across disciplines can be used to develop an integrated interactive multi-discipline numerical propulsion system simulator.

  3. Design and Integration of Wearable Devices in Textiles

    Directory of Open Access Journals (Sweden)

    Isabel G. TRINDADE

    2014-12-01

    Full Text Available In this article, the design, production method, integration and characterization of textile sensors for the continuous monitoring of cardiac and respiration vital signals are presented. Textile electrodes, capacitive and piezoresistive sensors and respective interconnect plate were developed and integrated in elastic and adjustable chest bands, using a 6-needle digital embroidery machine and electrically conductive commercial threads. The signal's waveforms were recorded via PC with a data acquisition module and a LabView program. The signal to noise ratio of textile electrodes, having distinctive surface morphologies, that were either textured or smooth accordingly with the embroidery pattern used, were analyzed with Matlab. The quantitative method indicated differences between the two types of textile electrodes but performances comparable to standard Ag/AgCl gel electrodes. The sensors and interconnect plate were fully realized with the embroidery stitching method with textile fabrics and threads, and have a compact design, are lightweight and washable. The method offers great versatility for custom demand, in terms of sensor design and materials.

  4. Integrated heat exchanger design for a cryogenic storage tank

    Energy Technology Data Exchange (ETDEWEB)

    Fesmire, J. E.; Bonner, T.; Oliveira, J. M.; Johnson, W. L.; Notardonato, W. U. [NASA Kennedy Space Center, Cryogenics Test Laboratory, NE-F6, KSC, FL 32899 (United States); Tomsik, T. M. [NASA Glenn Research Center, 21000 Brookpark Road, Cleveland, OH 44135 (United States); Conyers, H. J. [NASA Stennis Space Center, Building 3225, SSC, MS 39529 (United States)

    2014-01-29

    Field demonstrations of liquid hydrogen technology will be undertaken for the proliferation of advanced methods and applications in the use of cryofuels. Advancements in the use of cryofuels for transportation on Earth, from Earth, or in space are envisioned for automobiles, aircraft, rockets, and spacecraft. These advancements rely on practical ways of storage, transfer, and handling of liquid hydrogen. Focusing on storage, an integrated heat exchanger system has been designed for incorporation with an existing storage tank and a reverse Brayton cycle helium refrigerator of capacity 850 watts at 20 K. The storage tank is a 125,000-liter capacity horizontal cylindrical tank, with vacuum jacket and multilayer insulation, and a small 0.6-meter diameter manway opening. Addressed are the specific design challenges associated with the small opening, complete modularity, pressure systems re-certification for lower temperature and pressure service associated with hydrogen densification, and a large 8:1 length-to-diameter ratio for distribution of the cryogenic refrigeration. The approach, problem solving, and system design and analysis for integrated heat exchanger are detailed and discussed. Implications for future space launch facilities are also identified. The objective of the field demonstration will be to test various zero-loss and densified cryofuel handling concepts for future transportation applications.

  5. Design and Fabrication of Vertically-Integrated CMOS Image Sensors

    Science.gov (United States)

    Skorka, Orit; Joseph, Dileepan

    2011-01-01

    Technologies to fabricate integrated circuits (IC) with 3D structures are an emerging trend in IC design. They are based on vertical stacking of active components to form heterogeneous microsystems. Electronic image sensors will benefit from these technologies because they allow increased pixel-level data processing and device optimization. This paper covers general principles in the design of vertically-integrated (VI) CMOS image sensors that are fabricated by flip-chip bonding. These sensors are composed of a CMOS die and a photodetector die. As a specific example, the paper presents a VI-CMOS image sensor that was designed at the University of Alberta, and fabricated with the help of CMC Microsystems and Micralyne Inc. To realize prototypes, CMOS dies with logarithmic active pixels were prepared in a commercial process, and photodetector dies with metal-semiconductor-metal devices were prepared in a custom process using hydrogenated amorphous silicon. The paper also describes a digital camera that was developed to test the prototype. In this camera, scenes captured by the image sensor are read using an FPGA board, and sent in real time to a PC over USB for data processing and display. Experimental results show that the VI-CMOS prototype has a higher dynamic range and a lower dark limit than conventional electronic image sensors. PMID:22163860

  6. Reactor protection system design using application specific integrated circuits

    International Nuclear Information System (INIS)

    Battle, R.E.; Bryan, W.L.; Kisner, R.A.; Wilson, T.L. Jr.

    1992-01-01

    Implementing reactor protection systems (RPS) or other engineering safeguard systems with application specific integrated circuits (ASICs) offers significant advantages over conventional analog or software based RPSs. Conventional analog RPSs suffer from setpoints drifts and large numbers of discrete analog electronics, hardware logic, and relays which reduce reliability because of the large number of potential failures of components or interconnections. To resolve problems associated with conventional discrete RPSs and proposed software based RPS systems, a hybrid analog and digital RPS system implemented with custom ASICs is proposed. The actual design of the ASIC RPS resembles a software based RPS but the programmable software portion of each channel is implemented in a fixed digital logic design including any input variable computations. Set point drifts are zero as in proposed software systems, but the verification and validation of the computations is made easier since the computational logic an be exhaustively tested. The functionality is assured fixed because there can be no future changes to the ASIC without redesign and fabrication. Subtle error conditions caused by out of order evaluation or time dependent evaluation of system variables against protection criteria are eliminated by implementing all evaluation computations in parallel for simultaneous results. On- chip redundancy within each RPS channel and continuous self-testing of all channels provided enhanced assurance that a particular channel is available and faults are identified as soon as possible for corrective actions. The use of highly integrated ASICs to implement channel electronics rather than the use of discrete electronics greatly reduces the total number of components and interconnections in the RPS to further increase system reliability. A prototype ASIC RPS channel design and the design environment used for ASIC RPS systems design is discussed

  7. Model-Based Integrated Process Design and Controller Design of Chemical Processes

    DEFF Research Database (Denmark)

    Abd Hamid, Mohd Kamaruddin Bin

    that is typically formulated as a mathematical programming (optimization with constraints) problem is solved by the so-called reverse approach by decomposing it into four sequential hierarchical sub-problems: (i) pre-analysis, (ii) design analysis, (iii) controller design analysis, and (iv) final selection......This thesis describes the development and application of a new systematic modelbased methodology for performing integrated process design and controller design (IPDC) of chemical processes. The new methodology is simple to apply, easy to visualize and efficient to solve. Here, the IPDC problem...... are ordered according to the defined performance criteria (objective function). The final selected design is then verified through rigorous simulation. In the pre-analysis sub-problem, the concepts of attainable region and driving force are used to locate the optimal process-controller design solution...

  8. The Integration Method of Ceramic Arts in the Product Design

    Science.gov (United States)

    Shuxin, Wang

    2018-03-01

    As one of the four ancient civilization countries, the firing technology of ceramic invented by China has made a great contribution to the progress and development of human society. In modern life, even the development of technology still needs the ceramics, there are large number of artists who take the ceramics as carrier active in the field of contemporary art. The ceramics can be seen everywhere in our daily life, this paper mainly discusses the integration means of ceramic art in the product design.

  9. An engineering approach to an integrated value proposition design framework

    Directory of Open Access Journals (Sweden)

    Van Der Merwe, Carmen

    2015-05-01

    Full Text Available Numerous problems with product quality and time-to-market launches can be traced back to how the product lifecycle process is managed within the organisation. This article provides insight into how an integrated value proposition design framework shifts product lifecycle management from a product-centric view to a customer-centric view, through the use of good engineering practices as found in the systems engineering discipline. Combining this with methods and tools such as the Refined Kano model, Blue Ocean strategy, and the Generalised Bass model enables the organisation to enhance product and service quality while reducing the time-to-market for new value proposition launches.

  10. Integrating Cloud-Computing-Specific Model into Aircraft Design

    Science.gov (United States)

    Zhimin, Tian; Qi, Lin; Guangwen, Yang

    Cloud Computing is becoming increasingly relevant, as it will enable companies involved in spreading this technology to open the door to Web 3.0. In the paper, the new categories of services introduced will slowly replace many types of computational resources currently used. In this perspective, grid computing, the basic element for the large scale supply of cloud services, will play a fundamental role in defining how those services will be provided. The paper tries to integrate cloud computing specific model into aircraft design. This work has acquired good results in sharing licenses of large scale and expensive software, such as CFD (Computational Fluid Dynamics), UG, CATIA, and so on.

  11. Design of an integrated non-destructive plutonium assay facility

    International Nuclear Information System (INIS)

    Moore, C.B.

    1984-01-01

    The Department of Energy requires improved technology for nuclear materials accounting as an essential part of new plutonium processing facilities. New facilities are being constructed at the Savannah River Plant by the Du Pont Company, Operating Contractor, to recover plutonium from scrap and waste material generated at SRP and other DOE contract processing facilities. This paper covers design concepts and planning required to incorporate state-of-the-art plutonium assay instruments developed at several national laboratories into an integrated, at-line nuclear material accounting facility operating in the production area. 3 figures

  12. Integrated design support systems for conceptual design of a space power reactor

    International Nuclear Information System (INIS)

    Shimoda, Hiroshi; Yoshikawa, Hidekazu; Takahashi, Makoto; Takeoka, Satoshi; Nagamatsu, Takashi; Ishizaki, Hiroaki

    1999-01-01

    In the process of conceptual design of large and complex engineering systems such as a nuclear power reactor, there must be various human works by several fields of engineers on each stage of design, analysis and evaluation. In this study, we have rearranged the design information to reduce the human workloads and have studied an efficient method to support the conceptual design works by new information technologies. For this purpose, we have developed two design support environments for conceptual design of a space power reactor as a concrete design target. When constructing an integrated design support environment, VINDS, which employs virtual reality(VR) technology, we focused on visualization of physical structure, functional organization and analysis calculation with full usage of easy perception and direct manipulation of VR. On the other hand, when constructing another asynchronous and distributed design support environment, WINDS, which employs WWW technology, we improved the support functions for cooperative design works among various fields of experts. In this paper, the basic concepts, configurations and functions of the design support environments are first described, then the future improvement is surveyed by their intercomparison. (author)

  13. An integrated reliability-based design optimization of offshore towers

    International Nuclear Information System (INIS)

    Karadeniz, Halil; Togan, Vedat; Vrouwenvelder, Ton

    2009-01-01

    After recognizing the uncertainty in the parameters such as material, loading, geometry and so on in contrast with the conventional optimization, the reliability-based design optimization (RBDO) concept has become more meaningful to perform an economical design implementation, which includes a reliability analysis and an optimization algorithm. RBDO procedures include structural analysis, reliability analysis and sensitivity analysis both for optimization and for reliability. The efficiency of the RBDO system depends on the mentioned numerical algorithms. In this work, an integrated algorithms system is proposed to implement the RBDO of the offshore towers, which are subjected to the extreme wave loading. The numerical strategies interacting with each other to fulfill the RBDO of towers are as follows: (a) a structural analysis program, SAPOS, (b) an optimization program, SQP and (c) a reliability analysis program based on FORM. A demonstration of an example tripod tower under the reliability constraints based on limit states of the critical stress, buckling and the natural frequency is presented.

  14. The integration between Business Model Canvas and Manufacturing System Design

    Science.gov (United States)

    Prasetyawan, Y.; Maulida, N.; Lutvitasari, M. R.

    2018-04-01

    Business Model Canvas (BMC) is an increasingly popular business design tool especially for a start-up business and new business player. In general, BMC seeks a balance between effective working patterns with suppliers, good relation with customers and ability to understand and manage internal resources. This balance will expedite the implementation of Manufacturing System Design (MSD). The existing use of BMC and MSD is frequently applied separately at various business levels. BMC business plan is primarily to have engagement with customers and explore potential revenue to increase profits, while MSD primarily aims to meet production targets with available resources. The purpose of this research is to provide a roadmap to align BMC and MSD. A series of simple mathematical (modified) and integration models are created to connect BMC and MSD. Several results in various industries (new, developed and mature) are presented and used as examples of implementation.

  15. An integrated reliability-based design optimization of offshore towers

    Energy Technology Data Exchange (ETDEWEB)

    Karadeniz, Halil [Faculty of Civil Engineering and Geosciences, Delft University of Technology, Delft (Netherlands)], E-mail: h.karadeniz@tudelft.nl; Togan, Vedat [Department of Civil Engineering, Karadeniz Technical University, Trabzon (Turkey); Vrouwenvelder, Ton [Faculty of Civil Engineering and Geosciences, Delft University of Technology, Delft (Netherlands)

    2009-10-15

    After recognizing the uncertainty in the parameters such as material, loading, geometry and so on in contrast with the conventional optimization, the reliability-based design optimization (RBDO) concept has become more meaningful to perform an economical design implementation, which includes a reliability analysis and an optimization algorithm. RBDO procedures include structural analysis, reliability analysis and sensitivity analysis both for optimization and for reliability. The efficiency of the RBDO system depends on the mentioned numerical algorithms. In this work, an integrated algorithms system is proposed to implement the RBDO of the offshore towers, which are subjected to the extreme wave loading. The numerical strategies interacting with each other to fulfill the RBDO of towers are as follows: (a) a structural analysis program, SAPOS, (b) an optimization program, SQP and (c) a reliability analysis program based on FORM. A demonstration of an example tripod tower under the reliability constraints based on limit states of the critical stress, buckling and the natural frequency is presented.

  16. Designing a Fuzzy Strategic Integrated Multiechelon Agile Supply Chain Network

    Directory of Open Access Journals (Sweden)

    Morteza Abbasi

    2013-01-01

    Full Text Available This paper integrates production, distribution and logistics activities at the strategic decision making level, where the objective is to design a multiechelon supply chain network considering agility as a key design criterion. A network with five echelons of supply chains including suppliers, plants, distribution centers, cross-docks, and customer zones is addressed in this paper. The problem has been mathematically formulated as a biobjective optimization model that aims to minimize the cost (fixed and variable and maximize the plant flexibility and volume flexibility. A novel multiobjective parallel simulating annealing algorithm (MOPSA is proposed to obtain the Pareto-optimal solutions of the problem. The performance of the proposed solution algorithm is compared with two well-known metaheuristics, namely, nondominated sorting genetic algorithm (NSGA-II and Pareto archive evolution strategy (PAES. Computational results show that MOPSA outperforms the other metaheuristics.

  17. Design principles for achieving integrated healthcare information systems.

    Science.gov (United States)

    Jensen, Tina Blegind

    2013-03-01

    Achieving integrated healthcare information systems has become a common goal for many countries in their pursuit of obtaining coordinated and comprehensive healthcare services. This article focuses on how a small local project termed 'Standardized pull of patient data' expanded and is now used on a large scale providing a majority of hospitals, general practitioners and citizens across Denmark with the possibility of accessing healthcare data from different electronic patient record systems and other systems. I build on design theory for information infrastructures, as presented by Hanseth and Lyytinen, to examine the design principles that facilitated this smallscale project to expand and become widespread. As a result of my findings, I outline three lessons learned that emphasize: (i) principles of flexibility, (ii) expansion from the installed base through modular strategies and (iii) identification of key healthcare actors to provide them with immediate benefits.

  18. Integrated and Modular Design of an Optimized Process Architecture

    Directory of Open Access Journals (Sweden)

    Colin Raßfeld

    2013-07-01

    Full Text Available Global economic integration increased the complexity of business activities, so organizations are forced to become more efficient each day. Process organization is a very useful way of aligning organizational systems towards business processes. However, an organization must do more than just focus its attention and efforts on processes. The layout design has also a significant impact on the system performance.. We contribute to this field by developing a tailored process-oriented organizational structure and new layout design for the quality assurance of a leading German automotive manufacturer. The target concept we developed was evaluated by process owners and an IT-based process simulation. Our results provide solid empirical back-up in which the performance and effects are  assessed from a qualitative and quantitative perspective

  19. Design and testing of integrated circuits for reactor protection channels

    International Nuclear Information System (INIS)

    Battle, R.E.; Vandermolen, R.I.; Jagadish, U.; Swail, B.K.; Naser, J.

    1995-01-01

    Custom and semicustom application-specific integrated circuit design and testing methods are investigated for use in research and commercial nuclear reactor safety systems. The Electric Power Research Institute and Oak Ridge National Laboratory are working together through a cooperative research and development agreement to apply modern technology to a nuclear reactor protection system. The purpose of this project is to demonstrate to the nuclear industry an alternative approach for new or upgrade reactor protection and safety system signal processing and voting logic. Motivation for this project stems from (1) the difficulty of proving that software-based protection systems are adequately reliable, (2) the obsolescence of the original equipment, and (3) the improved performance of digital processing. A demonstration model for protection system of PWR reactor has been designed and built

  20. Design and integration of lower ports for ITER diagnostic systems

    Energy Technology Data Exchange (ETDEWEB)

    Casal, Natalia, E-mail: Natalia.casal@iter.org [ITER Organization, Route de Vinon-sur-Verdon – CS 90 046 – 13067 St Paul Lez Durance Cedex (France); Bertalot, Luciano; Cheng, Hao; Drevon, Jean Marc; Duckworth, Philip; Giacomin, Thibaud; Guirao, Julio; Iglesias, Silvia [ITER Organization, Route de Vinon-sur-Verdon – CS 90 046 – 13067 St Paul Lez Durance Cedex (France); Kochergin, Mikhail [IOFFE Institute, Saint Petersburg (Russian Federation); Martin, Alex [ITER Organization, Route de Vinon-sur-Verdon – CS 90 046 – 13067 St Paul Lez Durance Cedex (France); McCarron, Eddie [Oxford Technologies Ltd., Abingdon (United Kingdom); Mokeev, Alexander [Russian Federation Domestic Agency, Moscow (Russian Federation); Mota, Fernando [CIEMAT, Madrid (Spain); Penot, Christophe; Portales, Mickael [ITER Organization, Route de Vinon-sur-Verdon – CS 90 046 – 13067 St Paul Lez Durance Cedex (France); Kitazawa, Sin-iti [Japanese Domestic Agency, Naka (Japan); Sky, Jack [Oxford Technologies Ltd., Abingdon (United Kingdom); Suarez, Alejandro; Udintsev, Victor; Utin, Yuri [ITER Organization, Route de Vinon-sur-Verdon – CS 90 046 – 13067 St Paul Lez Durance Cedex (France); and others

    2015-10-15

    Highlights: • Lower port structures are in its conceptual design phase. • Electromagnetic and seismic loads, will dominate all other mechanical loads. • Design allows diagnostics support, neutron shielding while and signals transmission. • Installation and maintenance operations are fully remote handling compatible. - Abstract: All around the ITER vacuum vessel, forty-four ports will provide access to the vacuum vessel for remote handling operations, diagnostic systems, heating, and vacuum systems: 18 upper ports, 17 equatorial ports, and 9 lower ports. Among the lower ports, three of them will be used for the remote handling installation of the ITER divertor. Once the divertor is in place, these ports will host various diagnostic systems mounted in the so-called diagnostic racks. The diagnostic racks must allow the support and cooling of the diagnostics, extraction of the required diagnostic signals, and providing access and maintainability while minimizing the leakage of radiation toward the back of the port where the humans are allowed to enter. A fully integrated inner rack, carrying the near plasma diagnostic components, will be an stainless steel structure, 4.2 m long, with a maximum weight of 10 t. This structure brings water for cooling and baking at maximum temperature of 240 °C and provides connection with gas, vacuum and electric services. Additional racks (placed away from plasma and not requiring cooling) may be required for the support of some particular diagnostic components. The diagnostics racks and its associated ex vessel structures, which are in its conceptual design phase, are being designed to survive the lifetime of ITER of 20 years. This paper presents the current state of development including interfaces, diagnostic integration, operation and maintenance, shielding requirements, remote handling, loads cases and discussion of the main challenges coming from the severe environment and engineering requirements.

  1. Design and Development of an Integrated Workstation Automation Hub

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Andrew; Ghatikar, Girish; Sartor, Dale; Lanzisera, Steven

    2015-03-30

    Miscellaneous Electronic Loads (MELs) account for one third of all electricity consumption in U.S. commercial buildings, and are drivers for a significant energy use in India. Many of the MEL-specific plug-load devices are concentrated at workstations in offices. The use of intelligence, and integrated controls and communications at the workstation for an Office Automation Hub – offers the opportunity to improve both energy efficiency and occupant comfort, along with services for Smart Grid operations. Software and hardware solutions are available from a wide array of vendors for the different components, but an integrated system with interoperable communications is yet to be developed and deployed. In this study, we propose system- and component-level specifications for the Office Automation Hub, their functions, and a prioritized list for the design of a proof-of-concept system. Leveraging the strength of both the U.S. and India technology sectors, this specification serves as a guide for researchers and industry in both countries to support the development, testing, and evaluation of a prototype product. Further evaluation of such integrated technologies for performance and cost is necessary to identify the potential to reduce energy consumptions in MELs and to improve occupant comfort.

  2. Peculiarities of designing Holistic Electronic Government Services Integration Model

    Directory of Open Access Journals (Sweden)

    Tadas Limba

    2011-12-01

    Full Text Available Purpos– the aim ok this paper is to develop a Holistic Electronic Government Services Integration Model which could ensure the efficient integration of electronic government services in the local self-government level.Methodolog– the following analyses have been carried out in thirkpaper: theoretical-systematic; normative and conceptual comparative analysis of the researcha A method of modeling has also been applied.Finding– the scientific work analyzes the improvement opportunities of the models of electronic government services and their application alternatives in Lithuanian municipalities. The newly developed model of electronic government services that has been designed basng on the principle of integrating online expert consultation is primarily targeted at improvement of inside processes’ changes of an organization. Practicing the application of that model in the local self-government level starting with improvement of inside processes of an organization should help adapt more accurately and efficiently to the changing needs of the society while providing electronic government services, thus establishing a higher public value.Practical implication– the practical novelty of work is reflected not only through the integration opportunities’ assessment of the principle of online expert consultation services into the theoretical models of electronic government services that have already been developed by the scientists, but also on the basis of this principle there has been created a “Holistic Electronic Government Services Integration Model” in accordance with “E-Diamond” model basis and its practical application realization with the design of “The project of implementing the principle of online expert consultation on the model of electronic government services” for the future investigations.Originalit– the systematic, comparative analysis of the models of electronic government services carried out in the scientific

  3. A Supply Chain Design Problem Integrated Facility Unavailabilities Management

    Directory of Open Access Journals (Sweden)

    Fouad Maliki

    2016-08-01

    Full Text Available A supply chain is a set of facilities connected together in order to provide products to customers. The supply chain is subject to random failures caused by different factors which cause the unavailability of some sites. Given the current economic context, the management of these unavailabilities is becoming a strategic choice to ensure the desired reliability and availability levels of the different supply chain facilities. In this work, we treat two problems related to the field of supply chain, namely the design and unavailabilities management of logistics facilities. Specifically, we consider a stochastic distribution network with consideration of suppliers' selection, distribution centres location (DCs decisions and DCs’ unavailabilities management. Two resolution approaches are proposed. The first approach called non-integrated consists on define the optimal supply chain structure using an optimization approach based on genetic algorithms (GA, then to simulate the supply chain performance with the presence of DCs failures. The second approach called integrated approach is to consider the design of the supply chain problem and unavailabilities management of DCs in the same model. Note that, we replace each unavailable DC by performing a reallocation using GA in the two approaches. The obtained results of the two approaches are detailed and compared showing their effectiveness.

  4. Integrating availability and maintenance objectives in plant design. EDF approach

    International Nuclear Information System (INIS)

    Degrave, Claude; Martin-Onraet, Michel

    1995-01-01

    Energy self sufficiency is a major strategic necessity for France. Regarding the fossil fuels power, competitiveness of nuclear energy is a key goal for Electricite de France. Accordingly, for future nuclear power plants to remain competitive, it is necessary to maintain the kWh production costs of the future units at a level close to those of the latest units under construction (N4 series), while raising the safety level. EDF therefore decided to implement an analytical and systematic process for study of the new projects to optimize the design by integration of the maintenance (durations, costs), availability and radiation exposure goals from the related operating experience. This approach, CIDEM (French acronym for Design Integrating Availability, operating Experience and Maintenance) aims at a single goal: to minimize the kWh production cost incorporating investment, operation and fuel costs, allowing for the operating experience from French and foreign units. The implementation of the CIDEM process constitutes for EDF a new approach to the study of the new Nuclear Power Plant projects. The competitivity of nuclear energy greatly depends on the success of such an approach. The studies conducted in the availability field have already highlighted a number of critical points and have made it possible to define the corresponding goal allocations and to establish a first series of structuring specifications for the project. (J.P.N.)

  5. Design and integration of a hydrogen storage on metallic hydrides

    International Nuclear Information System (INIS)

    Botzung, M.

    2008-01-01

    This work presents a hydrogen storage system using metal hydrides for a Combined Heat and Power (CHP) system. Hydride storage technology has been chosen due to project specifications: high volumetric capacity, low pressures (≤ 3.5 bar) and low temperatures (≤ 75 C: fuel cell temperature). During absorption, heat from hydride generation is dissipated by fluid circulation. An integrated plate-fin type heat exchanger has been designed to obtain good compactness and to reach high absorption/desorption rates. At first, the storage system has been tested in accordance with project specifications (absorption 3.5 bar, desorption 1.5 bar). Then, the hydrogen charge/discharge times have been decreased to reach system limits. System design has been used to simulate thermal and mass comportment of the storage tank. The model is based on the software Fluent. We take in consideration heat and mass transfers in the porous media during absorption/desorption. The hydride thermal and mass behaviour has been integrated in the software. The heat and mass transfers experimentally obtained have been compared to results calculated by the model. The influence of experimental and numerical parameters on the model behaviour has also been explored. (author) [fr

  6. Radio frequency integrated circuit design for cognitive radio systems

    CERN Document Server

    Fahim, Amr

    2015-01-01

    This book fills a disconnect in the literature between Cognitive Radio systems and a detailed account of the circuit implementation and architectures required to implement such systems.  Throughout the book, requirements and constraints imposed by cognitive radio systems are emphasized when discussing the circuit implementation details.  In addition, this book details several novel concepts that advance state-of-the-art cognitive radio systems.  This is a valuable reference for anybody with background in analog and radio frequency (RF) integrated circuit design, needing to learn more about integrated circuits requirements and implementation for cognitive radio systems. ·         Describes in detail cognitive radio systems, as well as the circuit implementation and architectures required to implement them; ·         Serves as an excellent reference to state-of-the-art wideband transceiver design; ·         Emphasizes practical requirements and constraints imposed by cognitive radi...

  7. Integrated design of castings: effect of porosity on mechanical performance

    International Nuclear Information System (INIS)

    Hardin, R A; Beckermann, C

    2012-01-01

    Porosity can significantly reduce the strength and durability of castings in service. An integrated design approach has been developed where casting simulation is combined with mechanical performance simulations. Predictions of the porosity distribution from the casting process simulation are transferred to and used in stress and fatigue life simulations. Thus, the effect of casting quality on service performance can be evaluated. Results of a study are presented where the measured porosity distribution in cast steel specimens is transferred to an elasto-plastic finite-element stress analysis model. Methods are developed to locally reduce the mechanical properties according to the porosity present, without having to resolve individual pores. Plastic deformation is modeled using porous metal plasticity theory. The predictions are compared to tensile measurements performed on the specimens. The complex deformations and the reductions in the ductility of the specimens due to porosity are predicted well. The predicted stresses are transferred to a fatigue analysis code that takes the porosity distribution into account as well. The measured and predicted fatigue lives are also in good agreement. Finally, the results of a case study are presented that illustrate the utility of the present integrated approach in optimizing the design of a steel casting.

  8. Two-dimensional integrated Z-pinch ICF design simulations

    Energy Technology Data Exchange (ETDEWEB)

    Lash, J.S.

    1999-07-01

    The dynamic hohlraum ICF concept for a Z-pinch driver utilizes the imploding wire array collision with a target to produce a radiation history suitable for driving an embedded inertial confinement fusion (ICF) capsule. This target may consist of various shaped layers of low-density foams or solid-density materials. The use of detailed radiation magneto-hydrodynamic (RMHD) modeling is required for understanding and designing these complex systems. Critical to producing credible simulations and designs is inclusion of the Rayleigh-Taylor unstable wire-array dynamics; the bubble and spike structure of the collapsing sheath may yield regions of low-opacity enhancing radiation loss as well as introduce non-uniformities in the capsule's radiation drive. Recent improvements in LASNEX have allowed significant progress to be made in the modeling of unstable z-pinch implosions. Combining this with the proven ICF capsule design capabilities of LASNEX, the authors now have the modeling tools to produce credible, fully-integrated ICF dynamic hohlraum simulations. They present detailed two-dimensional RMHD simulations of recent ICF dynamic hohlraum experiments on the Sandia Z-machine as well as design simulations for the next-generation Z-pinch facility and future high-yield facility.

  9. Two-dimensional integrated Z-pinch ICF design simulations

    International Nuclear Information System (INIS)

    Lash, J.S.

    1999-01-01

    The dynamic hohlraum ICF concept for a Z-pinch driver utilizes the imploding wire array collision with a target to produce a radiation history suitable for driving an embedded inertial confinement fusion (ICF) capsule. This target may consist of various shaped layers of low-density foams or solid-density materials. The use of detailed radiation magneto-hydrodynamic (RMHD) modeling is required for understanding and designing these complex systems. Critical to producing credible simulations and designs is inclusion of the Rayleigh-Taylor unstable wire-array dynamics; the bubble and spike structure of the collapsing sheath may yield regions of low-opacity enhancing radiation loss as well as introduce non-uniformities in the capsule's radiation drive. Recent improvements in LASNEX have allowed significant progress to be made in the modeling of unstable z-pinch implosions. Combining this with the proven ICF capsule design capabilities of LASNEX, the authors now have the modeling tools to produce credible, fully-integrated ICF dynamic hohlraum simulations. They present detailed two-dimensional RMHD simulations of recent ICF dynamic hohlraum experiments on the Sandia Z-machine as well as design simulations for the next-generation Z-pinch facility and future high-yield facility

  10. Integrated Circuit Design in US High-Energy Physics

    Energy Technology Data Exchange (ETDEWEB)

    Geronimo, G. D. [Brookhaven National Lab. (BNL), Upton, NY (United States); Christian, D. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Bebek, C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Garcia-Sciveres, M. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Lippe, H. V. D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Haller, G. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Grillo, AA [Univ. of California, Santa Cruz, CA (United States); Newcomer, M [Univ. of Pennsylvania, Philadelphia, PA (United States)

    2013-07-10

    This whitepaper summarizes the status, plans, and challenges in the area of integrated circuit design in the United States for future High Energy Physics (HEP) experiments. It has been submitted to CPAD (Coordinating Panel for Advanced Detectors) and the HEP Community Summer Study 2013(Snowmass on the Mississippi) held in Minnesota July 29 to August 6, 2013. A workshop titled: US Workshop on IC Design for High Energy Physics, HEPIC2013 was held May 30 to June 1, 2013 at Lawrence Berkeley National Laboratory (LBNL). A draft of the whitepaper was distributed to the attendees before the workshop, the content was discussed at the meeting, and this document is the resulting final product. The scope of the whitepaper includes the following topics: Needs for IC technologies to enable future experiments in the three HEP frontiers Energy, Cosmic and Intensity Frontiers; Challenges in the different technology and circuit design areas and the related R&D needs; Motivation for using different fabrication technologies; Outlook of future technologies including 2.5D and 3D; Survey of ICs used in current experiments and ICs targeted for approved or proposed experiments; IC design at US institutes and recommendations for collaboration in the future.

  11. The design rationale of the Integral Fast Reactor (IFR)

    International Nuclear Information System (INIS)

    Wade, D.C.; Hill, R.N.

    1997-01-01

    The Integral Fast Reactor (IFR) concept has been developed over the last ten years to provide technical solutions to perceptual concerns associated with nuclear power. Beyond the traditional advanced reactor objectives of increased safety, improved economy and more efficient fuel utilization, the IFR is designed to simplify waste disposal and increase resistance to proliferation. Only a fast reactor with an efficient recycle technology can provide for total consumption of actinides. The basic physics governing reactor design dictates that, for efficient recycle, the fuel form should be limited in burnup only by radiation damage to fuel cladding. The recycle technology must recover essentially all actinides. In a fast reactor, not all fission products need to be removed from the recycled fuel, and there is no need to produce pure plutonium. Recovery, recycle, and ultimate consumption of all actinides resolves several waste-disposal concerns. The IFR can be configured to achieve safe passive response to any of the traditional postulated reactor accident initiators, and can be configured for a variety of power output levels. Passive heat removal is achieved by use of a large inventory sodium coolant and a physical configuration that emphasizes natural circulation. An IFR can be designed to consume excess fissile material, to produce a surplus, or to maintain inventory. It appears that commercial designs should be economically competitive with other available alternatives. (author)

  12. IT Requirements Integration in High-Rise Construction Design Projects

    Science.gov (United States)

    Levina, Anastasia; Ilin, Igor; Esedulaev, Rustam

    2018-03-01

    The paper discusses the growing role of IT support for the operation of modern high-rise buildings, due to the complexity of managing engineering systems of buildings and the requirements of consumers for the IT infrastructure. The existing regulatory framework for the development of design documentation for construction, including high-rise buildings, is analyzed, and the lack of coherence in the development of this documentation with the requirements for the creation of an automated management system and the corresponding IT infrastructure is stated. The lack of integration between these areas is the cause of delays and inefficiencies both at the design stage and at the stage of putting the building into operation. The paper proposes an approach to coordinate the requirements of the IT infrastructure of high-rise buildings and design documentation for construction. The solution to this problem is possible within the framework of the enterprise architecture concept by coordinating the requirements of the IT and technological layers at the design stage of the construction.

  13. Integrated design strategy for product life-cycle management

    Science.gov (United States)

    Johnson, G. Patrick

    2001-02-01

    Two major trends suggest new considerations for environmentally conscious manufacturing (ECM) -- the continuation of dematerialization and the growing trend toward goods becoming services. A diversity of existing research could be integrated around those trends in ways that can enhance ECM. Major research-based achievements in information, computation, and communications systems, sophisticated and inexpensive sensing capabilities, highly automated and precise manufacturing technologies, and new materials continue to drive the phenomenon of dematerialization - the reduction of the material and energy content of per capita GDP. Knowledge is also growing about the sociology, economics, mathematics, management and organization of complex socio-economic systems. And that has driven a trend towards goods evolving into services. But even with these significant trends, the value of material, energy, information and human resources incorporated into the manufacture, use and disposal of modern products and services often far exceeds the benefits realized. Multi-disciplinary research integrating these drivers with advances in ECM concepts could be the basis for a new strategy of production. It is argued that a strategy of integrating information resources with physical and human resources over product life cycles, together with considering products as streams of service over time, could lead to significant economic payoff. That strategy leads to an overall design concept to minimize costs of all resources over the product life cycle to more fully capture benefits of all resources incorporated into modern products. It is possible by including life cycle monitoring, periodic component replacement, re-manufacture, salvage and human factor skill enhancement into initial design.

  14. Designing optimal bioethanol networks with purification for integrated biorefineries

    International Nuclear Information System (INIS)

    Shenoy, Akshay U.; Shenoy, Uday V.

    2014-01-01

    Highlights: • An analytical method is devised for bioethanol network integration with purification. • Minimum fresh bioethanol flow and pinch are found by the Unified Targeting Algorithm. • Optimal bioethanol networks are then synthesized by the Nearest Neighbors Algorithm. • Continuous targets and networks are developed over the purifier inlet flowrate range. • Case study of a biorefinery producing bioethanol from wheat shows large savings. - Abstract: Bioethanol networks with purification for processing pathways in integrated biorefineries are targeted and designed in this work by an analytical approach not requiring graphical constructions. The approach is based on six fundamental equations involving eight variables: two balance equations for the stream flowrate and the bioethanol load over the total network system; one equation for the above-pinch bioethanol load being picked up by the minimum fresh resource and the purified stream; and three equations for the purification unit. A solution strategy is devised by specifying the two variables associated with the purifier inlet stream. Importantly, continuous targeting is then possible over the entire purifier inlet flowrate range on deriving elegant formulae for the remaining six variables. The Unified Targeting Algorithm (UTA) is utilized to establish the minimum fresh bioethanol resource flowrate and identify the pinch purity. The fresh bioethanol resource flowrate target is shown to decrease linearly with purifier inlet flowrate provided the pinch is held by the same point. The Nearest Neighbors Algorithm (NNA) is used to methodically synthesize optimal networks matching bioethanol demands and sources. A case study of a biorefinery producing bioethanol from wheat with arabinoxylan (AX) coproduction is presented. It illustrates the versatility of the approach in generating superior practical designs with up to nearly 94% savings for integrated bioethanol networks, both with and without process

  15. Understanding Creative Design Processes by Integrating Sketching and CAD Modelling Design Environments: A Preliminary Protocol Result from Architectural Designers

    Directory of Open Access Journals (Sweden)

    Yi Teng Shih

    2015-11-01

    Full Text Available This paper presents the results of a preliminary protocol study of the cognitive behaviour of architectural designers during the design process. The aim is to better understand the similarities and differences in cognitive behaviour using Sequential Mixed Media (SMM and Alternative Mixed Media (AMM approaches, and how switching between media may impact on design processes. Two participants with at least one-year’s professional design experience and a Bachelor of Design degree, and competence in both sketching and computer-aid design (CAD modelling participated in the study. Video recordings of participants working on different projects were coded using the Function-Behaviour-Structure (FBS coding scheme. Participants were also interviewed and their explanations about their switching behaviours were categorised into three types: S→C, S/C↹R and C→S. Preliminary results indicate that switching between media may influence how designers identify problems and develop solutions. In particular, two design issues were identified.  These relate to the FBS coding scheme, where structure (S and behaviour derived from structure (Bs, change to documentation (D after switching from sketching to CAD modelling (S→C. These switches make it possible for designers to integrate both approaches into one design medium and facilitate their design processes in AMM design environments.

  16. Inviscid/Boundary-Layer Aeroheating Approach for Integrated Vehicle Design

    Science.gov (United States)

    Lee, Esther; Wurster, Kathryn E.

    2017-01-01

    A typical entry vehicle design depends on the synthesis of many essential subsystems, including thermal protection system (TPS), structures, payload, avionics, and propulsion, among others. The ability to incorporate aerothermodynamic considerations and TPS design into the early design phase is crucial, as both are closely coupled to the vehicle's aerodynamics, shape and mass. In the preliminary design stage, reasonably accurate results with rapid turn-representative entry envelope was explored. Initial results suggest that for Mach numbers ranging from 9-20, a few inviscid solutions could reasonably sup- port surface heating predictions at Mach numbers variation of +/-2, altitudes variation of +/-10 to 20 kft, and angle-of-attack variation of +/- 5. Agreement with Navier-Stokes solutions was generally found to be within 10-15% for Mach number and altitude, and 20% for angle of attack. A smaller angle-of-attack increment than the 5 deg around times for parametric studies and quickly evolving configurations are necessary to steer design decisions. This investigation considers the use of an unstructured 3D inviscid code in conjunction with an integral boundary-layer method; the former providing the flow field solution and the latter the surface heating. Sensitivity studies for Mach number, angle of attack, and altitude, examine the feasibility of using this approach to populate a representative entry flight envelope based on a limited set of inviscid solutions. Each inviscid solution is used to generate surface heating over the nearby trajectory space. A subset of a considered in this study is recommended. Results of the angle-of-attack sensitivity studies show that smaller increments may be needed for better heating predictions. The approach is well suited for application to conceptual multidisciplinary design and analysis studies where transient aeroheating environments are critical for vehicle TPS and thermal design. Concurrent prediction of aeroheating

  17. Integrated predictive modelling simulations of burning plasma experiment designs

    International Nuclear Information System (INIS)

    Bateman, Glenn; Onjun, Thawatchai; Kritz, Arnold H

    2003-01-01

    Models for the height of the pedestal at the edge of H-mode plasmas (Onjun T et al 2002 Phys. Plasmas 9 5018) are used together with the Multi-Mode core transport model (Bateman G et al 1998 Phys. Plasmas 5 1793) in the BALDUR integrated predictive modelling code to predict the performance of the ITER (Aymar A et al 2002 Plasma Phys. Control. Fusion 44 519), FIRE (Meade D M et al 2001 Fusion Technol. 39 336), and IGNITOR (Coppi B et al 2001 Nucl. Fusion 41 1253) fusion reactor designs. The simulation protocol used in this paper is tested by comparing predicted temperature and density profiles against experimental data from 33 H-mode discharges in the JET (Rebut P H et al 1985 Nucl. Fusion 25 1011) and DIII-D (Luxon J L et al 1985 Fusion Technol. 8 441) tokamaks. The sensitivities of the predictions are evaluated for the burning plasma experimental designs by using variations of the pedestal temperature model that are one standard deviation above and below the standard model. Simulations of the fusion reactor designs are carried out for scans in which the plasma density and auxiliary heating power are varied

  18. Development of a one-step RT-PCR assay for detection of pancoronaviruses (α-, β-, γ-, and δ-coronaviruses) using newly designed degenerate primers for porcine and avian `fecal samples.

    Science.gov (United States)

    Hu, Hui; Jung, Kwonil; Wang, Qiuhong; Saif, Linda J; Vlasova, Anastasia N

    2018-06-01

    Coronaviruses (CoVs) are critical human and animal pathogens because of their potential to cause severe epidemics of respiratory or enteric diseases. In pigs, the newly emerged porcine deltacoronavirus (PDCoV) and re-emerged porcine epidemic diarrhea virus (PEDV) reported in the US and Asia, as well as the discovery of novel CoVs in wild bats or birds, has necessitated development of improved detection and control measures for these CoVs. Because the previous pancoronavirus (panCoV) RT-PCR established in our laboratory in 2007-2011 did not detect deltacoronaviruses (δ-CoVs) in swine fecal and serum samples, our goal was to develop a new panCoV RT-PCR assay to detect known human and animal CoVs, including δ-CoVs. In this study, we designed a new primer set to amplify a 668 bp-region within the RNA-dependent RNA polymerase (RdRP) gene that encodes the most conserved protein domain of α-, β-, γ-, and δ-CoVs. We established a one-step panCoV RT-PCR assay and standardized the assay conditions. The newly established panCoV RT-PCR assay was demonstrated to have a high sensitivity and specificity. Using a panel of 60 swine biological samples (feces, intestinal contents, and sera) characterized by PEDV, PDCoV and transmissible gastroenteritis virus-specific RT-PCR assays, we demonstrated that sensitivity and specificity of the newly established panCoV RT-PCR assay were 100%. 400 avian fecal (RNA) samples were further tested simultaneously for CoV by the new panCoV RT-PCR and a one-step RT-PCR assay with the δ-CoV nucleocapsid-specific universal primers. Four of 400 avian samples were positive for CoV, three of which were positive for δ-CoV by the conventional RT-PCR. PanCoV RT-PCR fragments for 3 of the 4 CoVs were sequenced. Phylogenetic analysis revealed the presence of one γ-CoV and two δ-CoV in the sequenced samples. The newly designed panCoV RT-PCR assay should be useful for the detection of currently known CoVs in animal biological samples. Copyright © 2018

  19. Design and testing of integrated circuits for reactor protection channels

    International Nuclear Information System (INIS)

    Battle, R.E.; Vandermolen, R.I.; Jagadish, U.; Swail, B.K.; Naser, J.; Rana, I.

    1995-01-01

    Custom and semicustom application-specific integrated circuit design and testing methods are investigated for use in research and commercial nuclear reactor safety systems. The Electric Power Research Institute and Oak Ridge National Laboratory are working together through a cooperative research and development agreement to apply modern technology to a nuclear reactor protection system. Purpose of this project is to demonstrate to the nuclear industry an alternative approach for new or upgrade reactor protection and safety system signal processing and voting logic. Motivation for this project stems from (1) the difficulty of proving that software-based protection systems are adequately reliable, (2) the obsolescence of the original equipment, and (3) the improved performance of digital processing

  20. Integrated Box Interrogation System (IBIS) Preliminary Design Study

    CERN Document Server

    Croft, S; Chard-Mj, P; Estop, J R; Martancik, D; Sheila-Melton; Young, B

    2003-01-01

    Canberra Industries has won the tendered solicitation, INEEL/EST-99-00121 for boxed waste Nondestructive Assay Development and Demonstration. Canberra will provide the Integrated Box Interrogation System (IBIS) which is a suite of assay instrumentation and a data reduction system that addresses the measurement needs for Boxed Wastes identified in the solicitation and facilitates the associated experimental program and demonstration of system capability. The IBIS system will consist of the next generation CWAM system, i.e. CWAM II, which is a Scanning Passive/Active Neutron interrogation system which we will call a Box Segmented Neutron Scanner (BSNS), combined with a physically separate Box Segmented Gamma-ray Scanning (BSGS) system. These systems are based on existing hardware designs but will be tailored to the large sample size and enhanced to allow the program to evaluate the following measurement criteria:Characterization and correction for matrix heterogeneity Characterization of non-uniform radio-nucli...

  1. Brayton Isotope Power System, Design Integrity Checklist (BIPS-DIC)

    Energy Technology Data Exchange (ETDEWEB)

    Miller, L.G.

    1976-06-10

    A preliminary Failure Modes, Effects and Criticality Analysis (FMECA) for the BIPS Flight System (FS) was published as AiResearch Report 76-311709 dated January 12, 1976. The FMECA presented a thorough review of the conceptual BIPS FS to identify areas of concern and activities necessary to avoid premature failures. In order to assure that the actions recommended by the FMECA are effected in both the FS and the Ground Demonstration System (GDS), a checklist (the BIPS-DIC) was prepared for the probability of occurrence of those failure modes that rated highest in criticality ranking. This checklist was circulated as an attachment to AiResearch Coordination Memo No. BIPS-GDS-A0106 dated January 23, 1976. The Brayton Isotope Power System-Design Integrity Checklist (BIPS-DIC) has been revised and is presented. Additional entries have been added that reference failure modes determined to rank highest in criticality ranking. The checklist will be updated periodically.

  2. Information delivery manuals to integrate building product information into design

    DEFF Research Database (Denmark)

    Berard, Ole Bengt; Karlshøj, Jan

    2011-01-01

    Despite continuing BIM progress, professionals in the AEC industry often lack the information they need to perform their work. Although this problem could be alleviated by information systems similar to those in other industries, companies struggle to model processes and information needs...... them in information systems. BIM implies that objects are bearers of information and logic. The present study has three main aims: (1) to explore IDMs capability to capture all four perspectives, (2) to determine whether an IDM’s collaborative methodology is valid for developing standardized processes......, and (3) to ascertain whether IDM’s business rules can support the development of information and logic-bearing BIM objects. The research is based on a case study of re-engineering the bidding process for a design-build project to integrate building product manufacturers, subcontractors...

  3. Using Multilayered Substrate Integrated Waveguide to Design Microwave Gain Equalizer

    Directory of Open Access Journals (Sweden)

    Yongfei Wang

    2014-01-01

    Full Text Available This paper presents the design and experiment of a novel microwave gain equalizer based on the substrate integrated waveguide (SIW technique. The proposed equalizer is formed by an SIW loaded by SIW resonators, which has very compact structure and can compensate for gain slope of microwave systems. Equivalent circuit analysis is given about the proposed structure for a better insight into the structure’s response. A Ku-Band equalizer with four SIW resonators is simulated and fabricated with a multilayer printed circuit board process. The measured results show good performance and agreement with the simulated results; an attenuation slope of −4.5 dB over 12.5–13.5 GHz is reached with a size reduction of 76%.

  4. INTEGRATED PRODUCT AND ENTERPRISE DESIGN FOR GLOBAL COMPETITIVENESS

    Directory of Open Access Journals (Sweden)

    N.D. Du Preez

    2012-01-01

    Full Text Available This paper presentsan overview of the challenge to integrate product and process life cycles in maintaining global competitiveness of an enterprise and proposes IEKOS as a possible solution . It provides the reader with a framework of two virtual life cycles which create a problem solving matrix for the industrial engineer. In this matrix, bordered by the virtual enterprise life cycle and the virtual product life cycles, the business functions of analyze, design deploy and operate are predominantly functions executed by the, industrial engineer. The different phases of each life cycle serves as a framework to a virtual industrial engineering toolkit providing access to detailed functions, formats, examples and a series of software and other "tools" available to the industrial engineer.
    In conclusion a brief overview is provided of the progress of the IEKOS toolkit which is under development at the department of Industrial Engineering at Stellenbosch University.

  5. Integrating protein engineering with process design for biocatalysis

    DEFF Research Database (Denmark)

    Woodley, John M.

    2017-01-01

    Biocatalysis uses enzymes for chemical synthesis and production, offering selective, safe and sustainable catalysis. While today the majority of applications are in the pharmaceutical sector, new opportunities are arising every day in other industry sectors, where production costs become a more...... important driver. In the early applications of the technology, it was necessary to design processes to match the properties of the biocatalyst. With the advent of protein engineering, organic chemists started to develop and improve enzymes to suit their needs. Likewise in industry, although not widespread......, a new paradigm was already implemented several years ago to engineer enzymes to suit process needs. Today, a new era is entered, where the effectiveness with which such integrated protein and process engineering is achieved becomes critical to implementation. In this paper, the development of a tool...

  6. An integrated approach to route selection in slurry pipeline design

    Energy Technology Data Exchange (ETDEWEB)

    Betinol, Roy G.; Altmann, Nara [Brass Chile S.A., Santiago (Chile)

    2009-12-19

    The pressure to get engineering projects done and constructed as fast as possible in order to take advantage of the high prices in metals and petrochemicals has been driving companies to skip the conceptual phase and go straight into basic engineering with cost estimates in the level of 15% accuracy. By-passing early engineering and demanding higher cost estimating accuracy is a contradiction. In most cases, savings made on capital investment is much higher had money been spent in conceptual studies which allow for the optimal solution to be found. This paper reviews one of the key aspects in conceptual engineering of slurry pipeline designs: route selection. This activity is often overlooked, causing capital cost and operating difficulties to rise unnecessarily. This paper describes and gives example on how an integrated client/engineering company's approach to route selection can produce significant savings in pipeline construction and operating costs. (author)

  7. Integrating Multibody Simulation and CFD: toward Complex Multidisciplinary Design Optimization

    Science.gov (United States)

    Pieri, Stefano; Poloni, Carlo; Mühlmeier, Martin

    This paper describes the use of integrated multidisciplinary analysis and optimization of a race car model on a predefined circuit. The objective is the definition of the most efficient geometric configuration that can guarantee the lowest lap time. In order to carry out this study it has been necessary to interface the design optimization software modeFRONTIER with the following softwares: CATIA v5, a three dimensional CAD software, used for the definition of the parametric geometry; A.D.A.M.S./Motorsport, a multi-body dynamic simulation software; IcemCFD, a mesh generator, for the automatic generation of the CFD grid; CFX, a Navier-Stokes code, for the fluid-dynamic forces prediction. The process integration gives the possibility to compute, for each geometrical configuration, a set of aerodynamic coefficients that are then used in the multiboby simulation for the computation of the lap time. Finally an automatic optimization procedure is started and the lap-time minimized. The whole process is executed on a Linux cluster running CFD simulations in parallel.

  8. Design of pressure vessels using shape optimization: An integrated approach

    Energy Technology Data Exchange (ETDEWEB)

    Carbonari, R.C., E-mail: ronny@usp.br [Department of Mechatronic Engineering, Escola Politecnica da Universidade de Sao Paulo, Av. Prof. Mello Moraes, 2231 Sao Paulo, SP 05508-900 (Brazil); Munoz-Rojas, P.A., E-mail: pablo@joinville.udesc.br [Department of Mechanical Engineering, Universidade do Estado de Santa Catarina, Bom Retiro, Joinville, SC 89223-100 (Brazil); Andrade, E.Q., E-mail: edmundoq@petrobras.com.br [CENPES, PDP/Metodos Cientificos, Petrobras (Brazil); Paulino, G.H., E-mail: paulino@uiuc.edu [Newmark Laboratory, Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, 205 North Mathews Av., Urbana, IL 61801 (United States); Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, 158 Mechanical Engineering Building, 1206 West Green Street, Urbana, IL 61801-2906 (United States); Nishimoto, K., E-mail: knishimo@usp.br [Department of Naval Architecture and Ocean Engineering, Escola Politecnica da Universidade de Sao Paulo, Av. Prof. Mello Moraes, 2231 Sao Paulo, SP 05508-900 (Brazil); Silva, E.C.N., E-mail: ecnsilva@usp.br [Department of Mechatronic Engineering, Escola Politecnica da Universidade de Sao Paulo, Av. Prof. Mello Moraes, 2231 Sao Paulo, SP 05508-900 (Brazil)

    2011-05-15

    Previous papers related to the optimization of pressure vessels have considered the optimization of the nozzle independently from the dished end. This approach generates problems such as thickness variation from nozzle to dished end (coupling cylindrical region) and, as a consequence, it reduces the optimality of the final result which may also be influenced by the boundary conditions. Thus, this work discusses shape optimization of axisymmetric pressure vessels considering an integrated approach in which the entire pressure vessel model is used in conjunction with a multi-objective function that aims to minimize the von-Mises mechanical stress from nozzle to head. Representative examples are examined and solutions obtained for the entire vessel considering temperature and pressure loading. It is noteworthy that different shapes from the usual ones are obtained. Even though such different shapes may not be profitable considering present manufacturing processes, they may be competitive for future manufacturing technologies, and contribute to a better understanding of the actual influence of shape in the behavior of pressure vessels. - Highlights: > Shape optimization of entire pressure vessel considering an integrated approach. > By increasing the number of spline knots, the convergence stability is improved. > The null angle condition gives lower stress values resulting in a better design. > The cylinder stresses are very sensitive to the cylinder length. > The shape optimization of the entire vessel must be considered for cylinder length.

  9. A High Integrity Can Design for Degraded Nuclear Fuel

    International Nuclear Information System (INIS)

    Holmes, P.A.

    1999-01-01

    A high integrity can (HIC), designed to meet the ASME Boiler and Pressure Vessel Code (Section III, Div. 3, static conditions) is proposed for the interim storage and repository disposal of Department of Energy (DOE) spent nuclear fuel. The HIC will be approximately 5 3/8 inches (134.38mm) in outside diameter with 1/4 inch (6.35mm) thick walls, and have a removable lid with a metallic seal that is capable of being welded shut. The opening of the can is approximately 4 3/8 inches (111.13mm). The HIC is primarily designed to contain items in the DOE SNF inventory that do not meet acceptance standards for direct disposal in a geologic repository. This includes fuel in the form of particulate dusts, sectioned pieces of fuel, core rubble, melted or degraded (non-intact) fuel elements, unclad uranium alloys, metallurgical specimens, and chemically reactive fuel components. The HIC is intended to act as a substitute cladding for the spent nuclear fuel, further isolate problematic materials, provide a long-term corrosion barrier, and add an extra internal pressure barrier to the waste package. The HIC will also delay potential fission product release and maintain geometry control for extended periods of time. For the entire disposal package to be licensed by the Nuclear Regulatory Commission, a HIC must effectively eliminate the disposal problems associated with problem SNF including the release of radioactive and/or reactive material and over pressurization of the HIC due to chemical reactions within the can. Two HICs were analyzed to envelop a range of can lengths between 42 and 101 inches. Using Abacus software, the HIC's were analyzed for end, side, and corner drops. Hastelloy C-22 was chosen based upon structural integrity, corrosion resistance, and neutron adsorption properties

  10. The calculus primer

    CERN Document Server

    Schaaf, William L

    2011-01-01

    Comprehensive but concise, this introduction to differential and integral calculus covers all the topics usually included in a first course. The straightforward development places less emphasis on mathematical rigor, and the informal manner of presentation sets students at ease. Many carefully worked-out examples illuminate the text, in addition to numerous diagrams, problems, and answers.Bearing the needs of beginners constantly in mind, the treatment covers all the basic concepts of calculus: functions, derivatives, differentiation of algebraic and transcendental functions, partial different

  11. IFMIF target and test cell - design and integration

    International Nuclear Information System (INIS)

    Heinzel, V.

    2007-01-01

    and shielding and material mutations - Pressure loss and heat transfer for helium cooling in mini channels like in the HFTM and jet cooling for the MFTM - Code for an automatic transfer of the CAD designs to the Monte Carlo code - Calculation for the lithium flow within the nozzle and the target During the 6 years ''Engineering Validation Engineering Design Activity'' phase carried out within the frame of the Broader Approach, FZK has major responsibilities in the design of TTC, in the validation of the helium cooling systems and in various design integration activities. The presentation will give an overview on the design tools, the state of the art of the miniaturised specimens and the design integration during EVEDA. (orig.)

  12. A LAN Primer.

    Science.gov (United States)

    Hazari, Sunil I.

    1991-01-01

    Local area networks (LANs) are systems of computers and peripherals connected together for the purposes of electronic mail and the convenience of sharing information and expensive resources. In planning the design of such a system, the components to consider are hardware, software, transmission media, topology, operating systems, and protocols.…

  13. Universal primers that amplify RNA from all three flavivirus subgroups

    Directory of Open Access Journals (Sweden)

    Barnard Ross T

    2008-01-01

    Full Text Available Abstract Background Species within the Flavivirus genus pose public health problems around the world. Increasing cases of Dengue and Japanese encephalitis virus in Asia, frequent outbreaks of Yellow fever virus in Africa and South America, and the ongoing spread of West Nile virus throughout the Americas, show the geographical burden of flavivirus diseases. Flavivirus infections are often indistinct from and confused with other febrile illnesses. Here we review the specificity of published primers, and describe a new universal primer pair that can detect a wide range of flaviviruses, including viruses from each of the recognised subgroups. Results Bioinformatic analysis of 257 published full-length Flavivirus genomes revealed conserved regions not previously targeted by primers. Two degenerate primers, Flav100F and Flav200R were designed from these regions and used to generate an 800 base pair cDNA product. The region amplified encoded part of the methyltransferase and most of the RNA-dependent-RNA-polymerase (NS5 coding sequence. One-step RT-PCR testing was successful using standard conditions with RNA from over 60 different flavivirus strains representing about 50 species. The cDNA from each virus isolate was sequenced then used in phylogenetic analyses and database searches to confirm the identity of the template RNA. Conclusion Comprehensive testing has revealed the broad specificity of these primers. We briefly discuss the advantages and uses of these universal primers.

  14. Integrated Design and Implementation of Embedded Control Systems with Scilab.

    Science.gov (United States)

    Ma, Longhua; Xia, Feng; Peng, Zhe

    2008-09-05

    Embedded systems are playing an increasingly important role in control engineering. Despite their popularity, embedded systems are generally subject to resource constraints and it is therefore difficult to build complex control systems on embedded platforms. Traditionally, the design and implementation of control systems are often separated, which causes the development of embedded control systems to be highly timeconsuming and costly. To address these problems, this paper presents a low-cost, reusable, reconfigurable platform that enables integrated design and implementation of embedded control systems. To minimize the cost, free and open source software packages such as Linux and Scilab are used. Scilab is ported to the embedded ARM-Linux system. The drivers for interfacing Scilab with several communication protocols including serial, Ethernet, and Modbus are developed. Experiments are conducted to test the developed embedded platform. The use of Scilab enables implementation of complex control algorithms on embedded platforms. With the developed platform, it is possible to perform all phases of the development cycle of embedded control systems in a unified environment, thus facilitating the reduction of development time and cost.

  15. Integrated Design and Implementation of Embedded Control Systems with Scilab

    Directory of Open Access Journals (Sweden)

    Zhe Peng

    2008-09-01

    Full Text Available Embedded systems are playing an increasingly important role in control engineering. Despite their popularity, embedded systems are generally subject to resource constraints and it is therefore difficult to build complex control systems on embedded platforms. Traditionally, the design and implementation of control systems are often separated, which causes the development of embedded control systems to be highly timeconsuming and costly. To address these problems, this paper presents a low-cost, reusable, reconfigurable platform that enables integrated design and implementation of embedded control systems. To minimize the cost, free and open source software packages such as Linux and Scilab are used. Scilab is ported to the embedded ARM-Linux system. The drivers for interfacing Scilab with several communication protocols including serial, Ethernet, and Modbus are developed. Experiments are conducted to test the developed embedded platform. The use of Scilab enables implementation of complex control algorithms on embedded platforms. With the developed platform, it is possible to perform all phases of the development cycle of embedded control systems in a unified environment, thus facilitating the reduction of development time and cost.

  16. Integrated Box Interrogation System (IBIS) Preliminary Design Study

    Energy Technology Data Exchange (ETDEWEB)

    DR. Stephen Croft; Mr. David Martancik; Dr. Brian Young; Dr. Patrick MJ Chard; Dr. Robert J Estop; Sheila Melton; Gaetano J. Arnone

    2003-01-13

    Canberra Industries has won the tendered solicitation, INEEL/EST-99-00121 for boxed waste Nondestructive Assay Development and Demonstration. Canberra will provide the Integrated Box Interrogation System (IBIS) which is a suite of assay instrumentation and a data reduction system that addresses the measurement needs for Boxed Wastes identified in the solicitation and facilitates the associated experimental program and demonstration of system capability. The IBIS system will consist of the next generation CWAM system, i.e. CWAM II, which is a Scanning Passive/Active Neutron interrogation system which we will call a Box Segmented Neutron Scanner (BSNS), combined with a physically separate Box Segmented Gamma-ray Scanning (BSGS) system. These systems are based on existing hardware designs but will be tailored to the large sample size and enhanced to allow the program to evaluate the following measurement criteria:Characterization and correction for matrix heterogeneity Characterization of non-uniform radio-nuclide and isotopic compositions Assay of high density matrices (both high-Z and high moderator contents)Correction for radioactive material physical form - such as self shielding or multiplication effects due to large accumulations of radioactive materials.Calibration with a minimal set of reference standards and representative matrices.THis document summarizes the conceptual design parameters of the IBIS and indicates areas key to the success of the project where development is to be centered. The work presented here is a collaborative effort between scientific staff within Canberra and within the NIS-6 group at LANL.

  17. Integrated Box Interrogation System (IBIS) Preliminary Design Study

    International Nuclear Information System (INIS)

    Croft, Stephen; Martancik, David; Young, Brian; Chard MJ, Patrick; Estop J, Robert; Sheila Melton; Arnone, Gaetano J.

    2003-01-01

    Canberra Industries has won the tendered solicitation, INEEL/EST-99-00121 for boxed waste Nondestructive Assay Development and Demonstration. Canberra will provide the Integrated Box Interrogation System (IBIS) which is a suite of assay instrumentation and a data reduction system that addresses the measurement needs for Boxed Wastes identified in the solicitation and facilitates the associated experimental program and demonstration of system capability. The IBIS system will consist of the next generation CWAM system, i.e. CWAM II, which is a Scanning Passive/Active Neutron interrogation system which we will call a Box Segmented Neutron Scanner (BSNS), combined with a physically separate Box Segmented Gamma-ray Scanning (BSGS) system. These systems are based on existing hardware designs but will be tailored to the large sample size and enhanced to allow the program to evaluate the following measurement criteria:Characterization and correction for matrix heterogeneity Characterization of non-uniform radio-nuclide and isotopic compositions Assay of high density matrices (both high-Z and high moderator contents)Correction for radioactive material physical form - such as self shielding or multiplication effects due to large accumulations of radioactive materials.Calibration with a minimal set of reference standards and representative matrices.THis document summarizes the conceptual design parameters of the IBIS and indicates areas key to the success of the project where development is to be centered. The work presented here is a collaborative effort between scientific staff within Canberra and within the NIS-6 group at LANL

  18. Integral Design Methodology of Photocatalytic Reactors for Air Pollution Remediation

    Directory of Open Access Journals (Sweden)

    Claudio Passalía

    2017-06-01

    Full Text Available An integral reactor design methodology was developed to address the optimal design of photocatalytic wall reactors to be used in air pollution control. For a target pollutant to be eliminated from an air stream, the proposed methodology is initiated with a mechanistic derived reaction rate. The determination of intrinsic kinetic parameters is associated with the use of a simple geometry laboratory scale reactor, operation under kinetic control and a uniform incident radiation flux, which allows computing the local superficial rate of photon absorption. Thus, a simple model can describe the mass balance and a solution may be obtained. The kinetic parameters may be estimated by the combination of the mathematical model and the experimental results. The validated intrinsic kinetics obtained may be directly used in the scaling-up of any reactor configuration and size. The bench scale reactor may require the use of complex computational software to obtain the fields of velocity, radiation absorption and species concentration. The complete methodology was successfully applied to the elimination of airborne formaldehyde. The kinetic parameters were determined in a flat plate reactor, whilst a bench scale corrugated wall reactor was used to illustrate the scaling-up methodology. In addition, an optimal folding angle of the corrugated reactor was found using computational fluid dynamics tools.

  19. GLobal Integrated Design Environment (GLIDE): A Concurrent Engineering Application

    Science.gov (United States)

    McGuire, Melissa L.; Kunkel, Matthew R.; Smith, David A.

    2010-01-01

    The GLobal Integrated Design Environment (GLIDE) is a client-server software application purpose-built to mitigate issues associated with real time data sharing in concurrent engineering environments and to facilitate discipline-to-discipline interaction between multiple engineers and researchers. GLIDE is implemented in multiple programming languages utilizing standardized web protocols to enable secure parameter data sharing between engineers and researchers across the Internet in closed and/or widely distributed working environments. A well defined, HyperText Transfer Protocol (HTTP) based Application Programming Interface (API) to the GLIDE client/server environment enables users to interact with GLIDE, and each other, within common and familiar tools. One such common tool, Microsoft Excel (Microsoft Corporation), paired with its add-in API for GLIDE, is discussed in this paper. The top-level examples given demonstrate how this interface improves the efficiency of the design process of a concurrent engineering study while reducing potential errors associated with manually sharing information between study participants.

  20. Integrated learning in practical machine element design course: a case study of V-pulley design

    Science.gov (United States)

    Tantrabandit, Manop

    2014-06-01

    To achieve an effective integrated learning in Machine Element Design course, it is of importance to bridge the basic knowledge and skills of element designs. The multiple core learning leads the pathway which consists of two main parts. The first part involves teaching documents of which the contents are number of V-groove formulae, standard of V-grooved pulleys, and parallel key dimension's formulae. The second part relates to the subjects that the students have studied prior to participating in this integrated learning course, namely Material Selection, Manufacturing Process, Applied Engineering Drawing, CAD (Computer Aided Design) animation software. Moreover, an intensive cooperation between a lecturer and students is another key factor to fulfill the success of integrated learning. Last but not least, the students need to share their knowledge within the group and among the other groups aiming to gain knowledge of and skills in 1) the application of CAD-software to build up manufacture part drawings, 2) assembly drawing, 3) simulation to verify the strength of loaded pulley by method of Finite Element Analysis (FEA), 4) the software to create animation of mounting and dismounting of a pulley to a shaft, and 5) an instruction manual. The end product of this integrated learning, as a result of the above 1 to 5 knowledge and skills obtained, the participating students can create an assembly derived from manufacture part drawings and a video presentation with bilingual (English-Thai) audio description of Vpulley with datum diameter of 250 mm, 4 grooves, and type of groove: SPA.

  1. Data Integration and Mining for Synthetic Biology Design.

    Science.gov (United States)

    Mısırlı, Göksel; Hallinan, Jennifer; Pocock, Matthew; Lord, Phillip; McLaughlin, James Alastair; Sauro, Herbert; Wipat, Anil

    2016-10-21

    One aim of synthetic biologists is to create novel and predictable biological systems from simpler modular parts. This approach is currently hampered by a lack of well-defined and characterized parts and devices. However, there is a wealth of existing biological information, which can be used to identify and characterize biological parts, and their design constraints in the literature and numerous biological databases. However, this information is spread among these databases in many different formats. New computational approaches are required to make this information available in an integrated format that is more amenable to data mining. A tried and tested approach to this problem is to map disparate data sources into a single data set, with common syntax and semantics, to produce a data warehouse or knowledge base. Ontologies have been used extensively in the life sciences, providing this common syntax and semantics as a model for a given biological domain, in a fashion that is amenable to computational analysis and reasoning. Here, we present an ontology for applications in synthetic biology design, SyBiOnt, which facilitates the modeling of information about biological parts and their relationships. SyBiOnt was used to create the SyBiOntKB knowledge base, incorporating and building upon existing life sciences ontologies and standards. The reasoning capabilities of ontologies were then applied to automate the mining of biological parts from this knowledge base. We propose that this approach will be useful to speed up synthetic biology design and ultimately help facilitate the automation of the biological engineering life cycle.

  2. A Cobit primer.

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, Philip LaRoche

    2005-06-01

    COBIT is a set of documents that provides guidance for computer security. This report introduces COBIT by answering the following questions, after first defining acronyms and presenting definitions: 1. Why is COBIT valuable? 2. What is COBIT?, and 3. What documents are related to COBIT? (The answer to the last question constitutes the bulk of this report.) This report also provides more detailed review of three documents. The first two documents--COBIT Security Baseline{trademark} and COBIT Quickstart{trademark}--are initial documents, designed to get people started. The third document-Control Practices-is a ''final'' document, so to speak, designed to take people all the way down into the details. Control Practices is the detail.

  3. A primer of statistical methods for correlating parameters and properties of electrospun poly(L-lactide) scaffolds for tissue engineering--PART 1: design of experiments.

    Science.gov (United States)

    Seyedmahmoud, Rasoul; Rainer, Alberto; Mozetic, Pamela; Maria Giannitelli, Sara; Trombetta, Marcella; Traversa, Enrico; Licoccia, Silvia; Rinaldi, Antonio

    2015-01-01

    Tissue engineering scaffolds produced by electrospinning are of enormous interest, but still lack a true understanding about the fundamental connection between the outstanding functional properties, the architecture, the mechanical properties, and the process parameters. Fragmentary results from several parametric studies only render some partial insights that are hard to compare and generally miss the role of parameters interactions. To bridge this gap, this article (Part-1 of 2) features a case study on poly-L-lactide scaffolds to demonstrate how statistical methods such as design of experiments can quantitatively identify the correlations existing between key scaffold properties and control parameters, in a systematic, consistent, and comprehensive manner disentangling main effects from interactions. The morphological properties (i.e., fiber distribution and porosity) and mechanical properties (Young's modulus) are "charted" as a function of molecular weight (MW) and other electrospinning process parameters (the Xs), considering the single effect as well as interactions between Xs. For the first time, the major role of the MW emerges clearly in controlling all scaffold properties. The correlation between mechanical and morphological properties is also addressed. © 2014 Wiley Periodicals, Inc.

  4. A primer of statistical methods for correlating parameters and properties of electrospun poly(l -lactide) scaffolds for tissue engineering-PART 1: Design of experiments

    KAUST Repository

    Seyedmahmoud, Rasoul

    2014-03-20

    Tissue engineering scaffolds produced by electrospinning are of enormous interest, but still lack a true understanding about the fundamental connection between the outstanding functional properties, the architecture, the mechanical properties, and the process parameters. Fragmentary results from several parametric studies only render some partial insights that are hard to compare and generally miss the role of parameters interactions. To bridge this gap, this article (Part-1 of 2) features a case study on poly-l-lactide scaffolds to demonstrate how statistical methods such as design of experiments can quantitatively identify the correlations existing between key scaffold properties and control parameters, in a systematic, consistent, and comprehensive manner disentangling main effects from interactions. The morphological properties (i.e., fiber distribution and porosity) and mechanical properties (Young\\'s modulus) are "charted" as a function of molecular weight (MW) and other electrospinning process parameters (the Xs), considering the single effect as well as interactions between Xs. For the first time, the major role of the MW emerges clearly in controlling all scaffold properties. The correlation between mechanical and morphological properties is also addressed.

  5. Blockchain: A Graph Primer

    OpenAIRE

    Akcora, Cuneyt Gurcan; Gel, Yulia R.; Kantarcioglu, Murat

    2017-01-01

    Bitcoin and its underlying technology Blockchain have become popular in recent years. Designed to facilitate a secure distributed platform without central authorities, Blockchain is heralded as a paradigm that will be as powerful as Big Data, Cloud Computing and Machine learning. Blockchain incorporates novel ideas from various fields such as public key encryption and distributed systems. As such, a reader often comes across resources that explain the Blockchain technology from a certain pers...

  6. Computer Aided Product Service Systems Design : Service CAD and Its integration with Life Cycle Simulation

    NARCIS (Netherlands)

    Komoto, H.

    2009-01-01

    Integration of product design into service design, or vice versa, is considered to bring more efficient and effective value addition. Besides EcoDesign tools and methods, a methodology to design such an integration of products and services from a systemic perspective, or product-service systems

  7. Freshwater Wetlands: A Citizen's Primer.

    Science.gov (United States)

    Catskill Center for Conservation and Development, Inc., Hobart, NY.

    The purpose of this "primer" for the general public is to describe the general characteristics of wetlands and how wetland alteration adversely affects the well-being of humans. Particular emphasis is placed on wetlands in New York State and the northeast. Topics discussed include wetland values, destruction of wetlands, the costs of…

  8. DNA Extraction and Primer Selection

    DEFF Research Database (Denmark)

    Karst, Søren Michael; Nielsen, Per Halkjær; Albertsen, Mads

    Talk regarding pitfalls in DNA extraction and 16S amplicon primer choice when performing community analysis of complex microbial communities. The talk was a part of Workshop 2 "Principles, Potential, and Limitations of Novel Molecular Methods in Water Engineering; from Amplicon Sequencing to -omics...

  9. A classical primer for QCD

    International Nuclear Information System (INIS)

    Moriyasu, K.

    1981-01-01

    A basic primer for QCD is presented using a semiclassical approach to the colour Maxwell equations. The non-Abelian nature of colour symmetry and the violation of superposition by colour fields is compared with QED. A simple discussion of asymptotic freedom is also presented. (author)

  10. Primer on hardware prefetching

    CERN Document Server

    Falsafi, Babak

    2014-01-01

    Since the 1970's, microprocessor-based digital platforms have been riding Moore's law, allowing for doubling of density for the same area roughly every two years. However, whereas microprocessor fabrication has focused on increasing instruction execution rate, memory fabrication technologies have focused primarily on an increase in capacity with negligible increase in speed. This divergent trend in performance between the processors and memory has led to a phenomenon referred to as the "Memory Wall."To overcome the memory wall, designers have resorted to a hierarchy of cache memory levels, whi

  11. A plastome primer set for comprehensive quantitative real time RT-PCR analysis of Zea mays: a starter primer set for other Poaceae species

    Directory of Open Access Journals (Sweden)

    Dunn Sade N

    2008-06-01

    Full Text Available Abstract Background Quantitative Real Time RT-PCR (q2(RTPCR is a maturing technique which gives researchers the ability to quantify and compare very small amounts of nucleic acids. Primer design and optimization is an essential yet time consuming aspect of using q2(RTPCR. In this paper we describe the design and empirical optimization of primers to amplify and quantify plastid RNAs from Zea mays that are robust enough to use with other closely related species. Results Primers were designed and successfully optimized for 57 of the 104 reported genes in the maize plastome plus two nuclear genes. All 59 primer pairs produced single amplicons after end-point reverse transcriptase polymerase chain reactions (RT-PCR as visualized on agarose gels and subsequently verified by q2(RTPCR. Primer pairs were divided into several categories based on the optimization requirements or the uniqueness of the target gene. An in silico test suggested the majority of the primer sets should work with other members of the Poaceae family. An in vitro test of the primer set on two unsequenced species (Panicum virgatum and Miscanthus sinensis supported this assumption by successfully producing single amplicons for each primer pair. Conclusion Due to the highly conserved chloroplast genome in plant families it is possible to utilize primer pairs designed against one genomic sequence to detect the presence and abundance of plastid genes or transcripts from genomes that have yet to be sequenced. Analysis of steady state transcription of vital system genes is a necessary requirement to comprehensively elucidate gene expression in any organism. The primer pairs reported in this paper were designed for q2(RTPCR of maize chloroplast genes but should be useful for other members of the Poaceae family. Both in silico and in vitro data are presented to support this assumption.

  12. National Ignition Facility sub-system design requirements integrated timing system SSDR 1.5.3

    International Nuclear Information System (INIS)

    Wiedwald, J.; Van Aersau, P.; Bliss, E.

    1996-01-01

    This System Design Requirement document establishes the performance, design, development, and test requirements for the Integrated Timing System, WBS 1.5.3 which is part of the NIF Integrated Computer Control System (ICCS). The Integrated Timing System provides all temporally-critical hardware triggers to components and equipment in other NIF systems

  13. Design And Implementation Of Integrated Vision-Based Robotic Workcells

    Science.gov (United States)

    Chen, Michael J.

    1985-01-01

    Reports have been sparse on large-scale, intelligent integration of complete robotic systems for automating the microelectronics industry. This paper describes the application of state-of-the-art computer-vision technology for manufacturing of miniaturized electronic components. The concepts of FMS - Flexible Manufacturing Systems, work cells, and work stations and their control hierarchy are illustrated in this paper. Several computer-controlled work cells used in the production of thin-film magnetic heads are described. These cells use vision for in-process control of head-fixture alignment and real-time inspection of production parameters. The vision sensor and other optoelectronic sensors, coupled with transport mechanisms such as steppers, x-y-z tables, and robots, have created complete sensorimotor systems. These systems greatly increase the manufacturing throughput as well as the quality of the final product. This paper uses these automated work cells as examples to exemplify the underlying design philosophy and principles in the fabrication of vision-based robotic systems.

  14. Active noise control primer

    CERN Document Server

    Snyder, Scott D

    2000-01-01

    Active noise control - the reduction of noise by generating an acoustic signal that actively interferes with the noise - has become an active area of basic research and engineering applications. The aim of this book is to present all of the basic knowledge one needs for assessing how useful active noise control will be for a given problem and then to provide some guidance for designing, setting up, and tuning an active noise-control system. Written for students who have no prior knowledge of acoustics, signal processing, or noise control but who do have a reasonable grasp of basic physics and mathematics, the book is short and descriptive. It leaves for more advanced texts or research monographs all mathematical details and proofs concerning vibrations, signal processing and the like. The book can thus be used in independent study, in a classroom with laboratories, or in conjunction with a kit for experiment or demonstration. Topics covered include: basic acoustics; human perception and sound; sound intensity...

  15. Design of a miniaturized integrated spectrometer for spectral tissue sensing

    Science.gov (United States)

    Belay, Gebirie Yizengaw; Hoving, Willem; Ottevaere, Heidi; van der Put, Arthur; Weltjens, Wim; Thienpont, Hugo

    2016-04-01

    Minimally-invasive image-guided procedures become increasingly used by physicians to obtain real-time characterization feedback from the tissue at the tip of their interventional device (needle, catheter, endoscopic or laparoscopic probes, etc…) which can significantly improve the outcome of diagnosis and treatment, and ultimately reduce cost of the medical treatment. Spectral tissue sensing using compact photonic probes has the potential to be a valuable tool for screening and diagnostic purposes, e.g. for discriminating between healthy and tumorous tissue. However, this technique requires a low-cost broadband miniature spectrometer so that it is commercially viable for screening at point-of-care locations such as physicians' offices and outpatient centers. Our goal is therefore to develop a miniaturized spectrometer based on diffractive optics that combines the functionalities of a visible/near-infrared (VIS/NIR) and shortwave-infrared (SWIR) spectrometer in one very compact housing. A second goal is that the hardware can be produced in high volume at low cost without expensive time consuming alignment and calibration steps. We have designed a miniaturized spectrometer which operates both in the visible/near-infrared and shortwave-infrared wavelength regions ranging from 400 nm to 1700 nm. The visible/near-infrared part of the spectrometer is designed for wavelengths from 400 nm to 800 nm whereas the shortwave-infrared segment ranges from 850 nm to 1700 nm. The spectrometer has a resolution of 6 nm in the visible/near-infrared wavelength region and 10 nm in the shortwave-infrared. The minimum SNR of the spectrometer for the intended application is about 151 in the VIS/NIR range and 6000 for SWIR. In this paper, the modelling and design, and power budget analysis of the miniaturized spectrometer are presented. Our work opens a door for future affordable micro- spectrometers which can be integrated with smartphones and tablets, and used for point

  16. Integrated Task And Data Parallel Programming: Language Design

    Science.gov (United States)

    Grimshaw, Andrew S.; West, Emily A.

    1998-01-01

    his research investigates the combination of task and data parallel language constructs within a single programming language. There are an number of applications that exhibit properties which would be well served by such an integrated language. Examples include global climate models, aircraft design problems, and multidisciplinary design optimization problems. Our approach incorporates data parallel language constructs into an existing, object oriented, task parallel language. The language will support creation and manipulation of parallel classes and objects of both types (task parallel and data parallel). Ultimately, the language will allow data parallel and task parallel classes to be used either as building blocks or managers of parallel objects of either type, thus allowing the development of single and multi-paradigm parallel applications. 1995 Research Accomplishments In February I presented a paper at Frontiers '95 describing the design of the data parallel language subset. During the spring I wrote and defended my dissertation proposal. Since that time I have developed a runtime model for the language subset. I have begun implementing the model and hand-coding simple examples which demonstrate the language subset. I have identified an astrophysical fluid flow application which will validate the data parallel language subset. 1996 Research Agenda Milestones for the coming year include implementing a significant portion of the data parallel language subset over the Legion system. Using simple hand-coded methods, I plan to demonstrate (1) concurrent task and data parallel objects and (2) task parallel objects managing both task and data parallel objects. My next steps will focus on constructing a compiler and implementing the fluid flow application with the language. Concurrently, I will conduct a search for a real-world application exhibiting both task and data parallelism within the same program m. Additional 1995 Activities During the fall I collaborated

  17. The Mixed Waste Management Facility. Design basis integrated operations plan (Title I design)

    International Nuclear Information System (INIS)

    1994-12-01

    The Mixed Waste Management Facility (MWMF) will be a fully integrated, pilotscale facility for the demonstration of low-level, organic-matrix mixed waste treatment technologies. It will provide the bridge from bench-scale demonstrated technologies to the deployment and operation of full-scale treatment facilities. The MWMF is a key element in reducing the risk in deployment of effective and environmentally acceptable treatment processes for organic mixed-waste streams. The MWMF will provide the engineering test data, formal evaluation, and operating experience that will be required for these demonstration systems to become accepted by EPA and deployable in waste treatment facilities. The deployment will also demonstrate how to approach the permitting process with the regulatory agencies and how to operate and maintain the processes in a safe manner. This document describes, at a high level, how the facility will be designed and operated to achieve this mission. It frequently refers the reader to additional documentation that provides more detail in specific areas. Effective evaluation of a technology consists of a variety of informal and formal demonstrations involving individual technology systems or subsystems, integrated technology system combinations, or complete integrated treatment trains. Informal demonstrations will typically be used to gather general operating information and to establish a basis for development of formal demonstration plans. Formal demonstrations consist of a specific series of tests that are used to rigorously demonstrate the operation or performance of a specific system configuration

  18. 30 CFR 56.6304 - Primer protection.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Primer protection. 56.6304 Section 56.6304 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Primer protection. (a) Tamping shall not be done directly on a primer. (b) Rigid cartridges of explosives...

  19. Complexity management in engineering design a primer

    CERN Document Server

    Maurer, Maik

    2017-01-01

    The treatise supports understanding the phenomena of complexity in engineering, distinguishes complexity from other challenges and presents an overview of definitions and applied approaches. The historical background of complexity management is explained by highlighting the important epochs, their key actors and their discoveries, findings and developments. Knowing about the appearance of early system awareness in ancient Greece, the creation of mechanical philosophy in the 17th century and the discovery of classic physics enables the reader to better comprehend modern system sciences and management approaches. A classification of complexity management approaches by research fields indicates current focus areas and starting points for future discussions. In a comprehensive map, the classification points out mutual overlaps between engineering disciplines in terms of similar complexity management approaches. Finally, the treatise introduces a generic complexity management framework, which is based on structura...

  20. Design of an Integrated Methodology for Analytical Design of Complex Supply Chains

    Directory of Open Access Journals (Sweden)

    Shahid Rashid

    2012-01-01

    Full Text Available A literature review and gap analysis indentifies key limitations of industry best practice when modelling of supply chains. To address these limitations the paper reports on the conception and development of an integrated modelling methodology designed to underpin the analytical design of complex supply chains. The methodology is based upon a systematic deployment of EM, CLD, and SM techniques; the integration of which is achieved via common modelling concepts and decomposition principles. Thereby the methodology facilitates: (i graphical representation and description of key “processing”, “resourcing” and “work flow” properties of supply chain configurations; (ii behavioural exploration of currently configured supply chains, to facilitate reasoning about uncertain demand impacts on supply, make, delivery, and return processes; (iii predictive quantification about relative performances of alternative complex supply chain configurations, including risk assessments. Guidelines for the application of each step of the methodology are described. Also described are recommended data collection methods and expected modelling outcomes for each step. The methodology is being extensively case tested to quantify potential benefits & costs relative to current best industry practice. The paper reflects on preliminary benefits gained during industry based case study modelling and identifies areas of potential improvement.

  1. Integrated aerodynamic-structural design of a forward-swept transport wing

    Science.gov (United States)

    Haftka, Raphael T.; Grossman, Bernard; Kao, Pi-Jen; Polen, David M.; Sobieszczanski-Sobieski, Jaroslaw

    1989-01-01

    The introduction of composite materials is having a profound effect on aircraft design. Since these materials permit the designer to tailor material properties to improve structural, aerodynamic and acoustic performance, they require an integrated multidisciplinary design process. Futhermore, because of the complexity of the design process, numerical optimization methods are required. The utilization of integrated multidisciplinary design procedures for improving aircraft design is not currently feasible because of software coordination problems and the enormous computational burden. Even with the expected rapid growth of supercomputers and parallel architectures, these tasks will not be practical without the development of efficient methods for cross-disciplinary sensitivities and efficient optimization procedures. The present research is part of an on-going effort which is focused on the processes of simultaneous aerodynamic and structural wing design as a prototype for design integration. A sequence of integrated wing design procedures has been developed in order to investigate various aspects of the design process.

  2. National Ignition Facility system design requirements NIF integrated computer controls SDR004

    International Nuclear Information System (INIS)

    Bliss, E.

    1996-01-01

    This System Design Requirement document establishes the performance, design, development, and test requirements for the NIF Integrated Computer Control System. The Integrated Computer Control System (ICCS) is covered in NIF WBS element 1.5. This document responds directly to the requirements detailed in the NIF Functional Requirements/Primary Criteria, and is supported by subsystem design requirements documents for each major ICCS Subsystem

  3. A service platform architecture design towards a light integration of heterogeneous systems in the wellbeing domain.

    Science.gov (United States)

    Yang, Yaojin; Ahtinen, Aino; Lahteenmaki, Jaakko; Nyman, Petri; Paajanen, Henrik; Peltoniemi, Teijo; Quiroz, Carlos

    2007-01-01

    System integration is one of the major challenges for building wellbeing or healthcare related information systems. In this paper, we are going to share our experiences on how to design a service platform called Nuadu service platform, for providing integrated services in occupational health promotion and health risk management through two heterogeneous systems. Our design aims for a light integration covering the layers, from data through service up to presentation, while maintaining the integrity of the underlying systems.

  4. A Primer to Slow Light

    OpenAIRE

    Leonhardt, U.

    2001-01-01

    Laboratory-based optical analogs of astronomical objects such as black holes rely on the creation of light with an extremely low or even vanishing group velocity (slow light). These brief notes represent a pedagogical attempt towards elucidating this extraordinary form of light. This paper is a contribution to the book Artificial Black Holes edited by Mario Novello, Matt Visser and Grigori Volovik. The paper is intended as a primer, an introduction to the subject for non-experts, not as a det...

  5. An environmentally acceptable primer for galvanized steel: Formulation and evaluation by SVET

    Energy Technology Data Exchange (ETDEWEB)

    Simoes, A.M.P., E-mail: alda.simoes@ist.utl.p [CIDEPINT - Centro de Investigacion y Desarrollo en Tecnologia de Pinturas (CIC-CONICET), Calle 52 e/121 y 122, 1900 La Plata (Argentina); TULisbon, Instituto Superior Tecnico, DEQB, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Carbonari, R.O.; Di Sarli, A.R.; Amo, B. del [CIDEPINT - Centro de Investigacion y Desarrollo en Tecnologia de Pinturas (CIC-CONICET), Calle 52 e/121 y 122, 1900 La Plata (Argentina); TULisbon, Instituto Superior Tecnico, DEQB, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Romagnoli, R., E-mail: estelectro@cidepint.gov.a [CIDEPINT - Centro de Investigacion y Desarrollo en Tecnologia de Pinturas (CIC-CONICET), Calle 52 e/121 y 122, 1900 La Plata (Argentina); TULisbon, Instituto Superior Tecnico, DEQB, Av. Rovisco Pais, 1049-001 Lisboa (Portugal)

    2011-01-15

    Research highlights: {yields} Chromates can be replaced successfully by aluminium phosphosilicate in paint systems. {yields} The solvents of the primer are eco-friendly ones. {yields} The primer adheres on galvanized steel and allows top-coating. {yields} The binder of the primer is compatible with other binders for top-coating. - Abstract: The object of this paper was to formulate a two-pack wash primer employing aluminium phosphosilicate as active anticorrosive pigment instead of basic zinc chromate. The anticorrosive action of the primer was evaluated by the polarization technique and the scanning vibrating electrode technique (SVET). The exposed surface was then examined by scanning electron microscopy (SEM) and the surface composition determined by energy dispersive X-ray (EDX) analysis. The primer was finally integrated in a complete paint scheme whose anticorrosive performance was evaluated by the salt spray chamber and electrochemical impedance spectroscopy. The adhesion of the primer plus a painting system was also evaluated by standard ASTM D 3359-90 test method. The wash primer pigmented with zinc chromate was used as reference. Results indicated that basic zinc chromate could be replaced by the more eco-friendly wash-primer containing aluminium phosphosilicate.

  6. A comprehensive collection of experimentally validated primers for Polymerase Chain Reaction quantitation of murine transcript abundance

    Directory of Open Access Journals (Sweden)

    Wang Xiaowei

    2008-12-01

    Full Text Available Abstract Background Quantitative polymerase chain reaction (QPCR is a widely applied analytical method for the accurate determination of transcript abundance. Primers for QPCR have been designed on a genomic scale but non-specific amplification of non-target genes has frequently been a problem. Although several online databases have been created for the storage and retrieval of experimentally validated primers, only a few thousand primer pairs are currently present in existing databases and the primers are not designed for use under a common PCR thermal profile. Results We previously reported the implementation of an algorithm to predict PCR primers for most known human and mouse genes. We now report the use of that resource to identify 17483 pairs of primers that have been experimentally verified to amplify unique sequences corresponding to distinct murine transcripts. The primer pairs have been validated by gel electrophoresis, DNA sequence analysis and thermal denaturation profile. In addition to the validation studies, we have determined the uniformity of amplification using the primers and the technical reproducibility of the QPCR reaction using the popular and inexpensive SYBR Green I detection method. Conclusion We have identified an experimentally validated collection of murine primer pairs for PCR and QPCR which can be used under a common PCR thermal profile, allowing the evaluation of transcript abundance of a large number of genes in parallel. This feature is increasingly attractive for confirming and/or making more precise data trends observed from experiments performed with DNA microarrays.

  7. WASP: a Web-based Allele-Specific PCR assay designing tool for detecting SNPs and mutations

    Directory of Open Access Journals (Sweden)

    Assawamakin Anunchai

    2007-08-01

    Full Text Available Abstract Background Allele-specific (AS Polymerase Chain Reaction is a convenient and inexpensive method for genotyping Single Nucleotide Polymorphisms (SNPs and mutations. It is applied in many recent studies including population genetics, molecular genetics and pharmacogenomics. Using known AS primer design tools to create primers leads to cumbersome process to inexperience users since information about SNP/mutation must be acquired from public databases prior to the design. Furthermore, most of these tools do not offer the mismatch enhancement to designed primers. The available web applications do not provide user-friendly graphical input interface and intuitive visualization of their primer results. Results This work presents a web-based AS primer design application called WASP. This tool can efficiently design AS primers for human SNPs as well as mutations. To assist scientists with collecting necessary information about target polymorphisms, this tool provides a local SNP database containing over 10 million SNPs of various populations from public domain databases, namely NCBI dbSNP, HapMap and JSNP respectively. This database is tightly integrated with the tool so that users can perform the design for existing SNPs without going off the site. To guarantee specificity of AS primers, the proposed system incorporates a primer specificity enhancement technique widely used in experiment protocol. In particular, WASP makes use of different destabilizing effects by introducing one deliberate 'mismatch' at the penultimate (second to last of the 3'-end base of AS primers to improve the resulting AS primers. Furthermore, WASP offers graphical user interface through scalable vector graphic (SVG draw that allow users to select SNPs and graphically visualize designed primers and their conditions. Conclusion WASP offers a tool for designing AS primers for both SNPs and mutations. By integrating the database for known SNPs (using gene ID or rs number

  8. Integrating Design Decision Management with Model-based Software Development

    DEFF Research Database (Denmark)

    Könemann, Patrick

    Design decisions are continuously made during the development of software systems and are important artifacts for design documentation. Dedicated decision management systems are often used to capture such design knowledge. Most such systems are, however, separated from the design artifacts...... of the system. In model-based software development, where design models are used to develop a software system, outcomes of many design decisions have big impact on design models. The realization of design decisions is often manual and tedious work on design models. Moreover, keeping design models consistent......, or by ignoring the causes. This substitutes manual reviews to some extent. The concepts, implemented in a tool, have been validated with design patterns, refactorings, and domain level tests that comprise a replay of a real project. This proves the applicability of the solution to realistic examples...

  9. Integration process of theoretical courses with design studios in undergraduate education: Case studies of architecture and interior design studios

    Directory of Open Access Journals (Sweden)

    Ozmehmet Ecehan

    2016-01-01

    Full Text Available The formulations of studios are the most critical problem of design studies, because the foundation of further architectural education is based on these design studios. This paper focuses on discussions of studiobased design learning systems and curriculum developments on integral design studios that aims significant and innovative frameworks. In this context, integrated design studios are the newest approaches of architectural education. In this education system every studio has its own integral course. Integral courses give support to the design studios. This support can be either theoretical or practical. Knowledge that is related with the context of the design studio can be explained in this integrated course in some cases, in some cases as simulation program can be explained in some parts of the course. The support of the integral courses to the studios must be evaluated deeply. This paper presents the positive parts and negative parts of the new integral studio approach in this context. By this way, strong and weak parts of this education system is put forward.

  10. CMOS analog integrated circuit design technology; CMOS anarogu IC sekkei gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    Fujimoto, H.; Fujisawa, A. [Fuji Electric Co. Ltd., Tokyo (Japan)

    2000-08-10

    In the field of the LSI (large scale integrated circuit) in rapid progress toward high integration and advanced functions, CAD (computer-aided design) technology has become indispensable to LSI development within a short period. Fuji Electric has developed design technologies and automatic design system to develop high-quality analog ICs (integrated circuits), including power supply ICs. within a short period. This paper describes CMOS (complementary metal-oxide semiconductor) analog macro cell, circuit simulation, automatic routing, and backannotation technologies. (author)

  11. Finite volume method room acoustic simulations integrated into the architectural design process

    DEFF Research Database (Denmark)

    Pind Jörgensson, Finnur Kári; Jeong, Cheol-Ho; Engsig-Karup, Allan Peter

    2017-01-01

    with the architectural design from the earliest design stage, as a part of a holistic design process. A new procedure to integrate room acoustics into architectural design is being developed in a Ph.D. project, with the aim of promoting this early stage holistic design process. This project aims to develop a new hybrid...

  12. Design, Fabrication, Characterization and Modeling of Integrated Functional Materials

    Science.gov (United States)

    2015-12-01

    activities is expected to lead to new devices/ systems /composite materials useful for the USAMRMC. 15. SUBJECT TERMS Functional materials, integrated...fabrication, nanobiotechnology, multifunctional, dimensional integration, nanocomposites, sensor technology, thermoelectrics, solar cells, photovoltaics ...loop measured in the presence of an AC field, and can be increased by tuning several parameters, such as the nanoparticles’ size , saturation

  13. Integrating SAP to Information Systems Curriculum: Design and Delivery

    Science.gov (United States)

    Wang, Ming

    2011-01-01

    Information Systems (IS) education is being transformed from the segmented applications toward the integrated enterprise-wide system software Enterprise Resource Planning (ERP). ERP is a platform that integrates all business functions with its centralized data repository shared by all the business operations in the enterprise. This tremendous…

  14. Integration in design and manufacturing of polymer smart devices

    NARCIS (Netherlands)

    Bolt, P.J.; Zwart, R.M. de; Tacken, R.A.; Rendering, H.

    2009-01-01

    Integration of functions in single components is pursued in order to manufacture smaller and smarter polymer micro devices at less cost, through e.g. less assembly steps. It requires integration on both product and production side. This paper addresses the use of molded interconnect device (MID)

  15. Designing Indoor Climate. A Thesis on the Integration of Indoor Climate Analysis in Architectural Design

    Energy Technology Data Exchange (ETDEWEB)

    Den Hartog, J.P.

    2003-12-01

    In contemporary architecture education, indoor climate and building installations suffer from a lack of popularity. Students of architecture, filled with great expectations and awe for the famous designers of the 20th century, find inspiration in examples such as Le Corbusier's Villa Savoy, Lloyd Wright's falling water or the Rietveld's Schroder house. Recognizable as this may be, great aesthetics constitute only a small part of creating architecture. The process of designing and constructing buildings comprises the involvement of a multitude of skills such as creating clear functional layouts, designing solid structures and taking care of healthy indoor climates. Most textbooks and magazines contemporary architecture do not cover the less attractive aspects of the indoor climate such as heating, ventilation and cooling unless these services form an important part of the buildings aesthetic identity. Recent examples regarding the integration of second skin facades and natural ventilation in indoor climate, sometimes fail to convince as a result of the lack of thorough evaluations and detailed information.

  16. Taxon-specific PCR primers to detect two inconspicuous arbuscular mycorrhizal fungi from temperate agricultural grassland

    NARCIS (Netherlands)

    Gamper, H.A.; Leuchtmann, A.

    2007-01-01

    Taxon-specific polymerase chain reaction (PCR) primers enable detection of arbuscular mycorrhizal fungi (AMF, Glomeromycota) in plant roots where the fungi lack discriminative morphological and biochemical characters. We designed and validated pairs of new PCR primers targeted to the flanking

  17. Implementación modelo de acompañamiento a estudiantes de primer año que ingresan vía cupo pace a la Universidad Alberto Hurtado para disminuir el abandono: tutores de acompañamiento integral

    OpenAIRE

    Fernández, Natalia; Alvarado, Carol; Barría, Gonzalo; Macho, Natalia

    2017-01-01

    En el presente trabajo se comparte la experiencia de un modelo de acompañamiento a estudiantes de primer año a través de tutores de acompañamiento integral (TAI). Esta propuesta se enmarca en el Programa de Acompañamiento y Acceso Efectivo a la Educación Superior PACE del Ministerio de Educación de Chile, específicamente en la Universidad Alberto Hurtado (UAH) y en su componente Acompañamiento en la Educación Superior (AES). Se realiza un acompañamiento académico y psicoeducativo a este grupo...

  18. The design of integrated cooling processes in district heating systems; Kylprocessers design i fjaerrvaermesystem

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Viktoria [Royal Inst. of Technology, Stockholm (SE). Dept. of Chemical Engineering and Technology; Setterwall, Fredrik [Fredrik Setterwall Konsult AB, Sollentuna (Sweden); Andersson, Mikael [AB Berglunds Rostfria, Boden (Sweden)

    2005-07-01

    This report presents the results from an investigation regarding the design of integrated cooling processes in district heating systems. Increasing investment levels in district heating networks combined with expanding comfort cooling demand makes heat-driven cooling processes extremely interesting. This solution has a great potential tbe cost effective. At the same time, the problem with the environmentally harmful refrigerants used in conventional vapor compression chillers is avoided. In many cases it is beneficial for the district heating provider to lower the supply and/or return temperatures in the network, at least for part of the year. In combined heat and power generation (CHP) a lower supply temperature means that the electricity yield increases. In this context, it is important to consider that conventional absorption chillers are designed to run on 120 deg C heat. However,they can work on heat with temperature as low as 80 deg C if a chiller with a large enough generator area is used, although this has a negative impact on the dimensions of other components and leads ta lower coefficient of performance. For these reasons low temperature driven absorption chillers have been developed in recent years. Two concepts (from different manufacturers) are now available on the market. Factors that affect the choice of district heat-integrated cooling processes have been investigated in this study. Key system aspects that embody a holistic view on the production of heating, cooling and power are especially highlighted. Important tasks have been: To quantify the following effects on the design of an integrated cooling process: the temperatures in the district heating net, available cooling water temperature (to cool the absorber and condenser), electricity price, and the composition of the energy system (e.g. fuel and CHP or power-only mode of operation). To analyze the potential of the low temperature driven chiller concept with regards to energy and cost

  19. Primer on CDM programme of activities

    Energy Technology Data Exchange (ETDEWEB)

    Hinostroza, M. (UNEP Risoe Centre, Roskilde (Denmark)); Lescano, A.D. (A2G Carbon Partners (Peru)); Alvarez, J.M. (Ministerio del Ambiente del Peru (Peru)); Avendano, F.M. (EEA Fund Management Ltd. (United Kingdom)

    2009-07-01

    As an advanced modality introduced in 2005, the Programmatic CDM (POA) is expected to address asymmetries of participation, especially of very small-scale project activities in certain areas, key sectors and many countries with considerable potential for greenhouse gas emission reductions, not reached by the traditional single-project-based CDM. Latest experiences with POAs and the recently finalized official guidance governing the Programmatic CDM are the grassroots of this Primer, which has the purpose of supporting the fully understanding of rules and procedures of POAs by interpreting them and analyzing real POA cases. Professional and experts from the public and private entities have contributed to the development of this Primer, produced by the UNEP Risoe Centre, as part of knowledge support activities for the Capacity Development for the CDM (CD4CDM) project. The overall objective of the CD4CDM is to develop the capacities of host countries to identify, design, approve, finance, implement CDM projects and commercialize CERs in participating countries. The CDM4CDM is funded by the Netherlands Ministry of Foreign Affairs. (author)

  20. KENO-VI Primer: A Primer for Criticality Calculations with SCALE/KENO-VI Using GeeWiz

    International Nuclear Information System (INIS)

    Bowman, Stephen M.

    2008-01-01

    The SCALE (Standardized Computer Analyses for Licensing Evaluation) computer software system developed at Oak Ridge National Laboratory is widely used and accepted around the world for criticality safety analyses. The well-known KENO-VI three-dimensional Monte Carlo criticality computer code is one of the primary criticality safety analysis tools in SCALE. The KENO-VI primer is designed to help a new user understand and use the SCALE/KENO-VI Monte Carlo code for nuclear criticality safety analyses. It assumes that the user has a college education in a technical field. There is no assumption of familiarity with Monte Carlo codes in general or with SCALE/KENO-VI in particular. The primer is designed to teach by example, with each example illustrating two or three features of SCALE/KENO-VI that are useful in criticality analyses. The primer is based on SCALE 6, which includes the Graphically Enhanced Editing Wizard (GeeWiz) Windows user interface. Each example uses GeeWiz to provide the framework for preparing input data and viewing output results. Starting with a Quickstart section, the primer gives an overview of the basic requirements for SCALE/KENO-VI input and allows the user to quickly run a simple criticality problem with SCALE/KENO-VI. The sections that follow Quickstart include a list of basic objectives at the beginning that identifies the goal of the section and the individual SCALE/KENO-VI features that are covered in detail in the sample problems in that section. Upon completion of the primer, a new user should be comfortable using GeeWiz to set up criticality problems in SCALE/KENO-VI. The primer provides a starting point for the criticality safety analyst who uses SCALE/KENO-VI. Complete descriptions are provided in the SCALE/KENO-VI manual. Although the primer is self-contained, it is intended as a companion volume to the SCALE/KENO-VI documentation. (The SCALE manual is provided on the SCALE installation DVD.) The primer provides specific examples of

  1. Power of design - the future of building-integrated PV

    International Nuclear Information System (INIS)

    Abbate, Cinzia

    2001-01-01

    This paper discusses strategies to make building integrated photovoltaic (PV) systems more acceptable and to allow PV material to compete with conventional construction material. The history of developments in building integration and difficulties encountered by architects wishing to use PV products are explored, and the Dutch Amersfoot project in Utrecht involving a new suburb of 501 house covered with PV panels is described. Questions raised regarding architectural integration of PV systems, and PV systems and the construction market are discussed. The Italian PV programme, financial and political constraints, and the positioning of PV on existing structures are reported

  2. Design and application of multilayer monolithic microwave integrated circuit transformers

    Energy Technology Data Exchange (ETDEWEB)

    Economides, S.B

    1999-07-01

    The design and performance of planar spiral transformers, using multilayer GaAs and silicon MMIC technology, are presented. This multilayer technology gives new opportunities for improving the performance of planar transformers, couplers and baluns. Planar transformers have high parasitic resistance and capacitance and low levels of coupling. Using multilayer technology these problems are overcome by applying a multilayer structure of three metal layers separated by two polyimide dielectric layers. The improvements gained by placing the conductors on different metal layers, and using conductors raised on polyimide layers for low capacitance, have been investigated. The circuits were fabricated using a novel experimental fabrication process, which uses entirely standard materials and techniques and is compatible with BJT's and silicon-germanium HBT's. The transformers were all characterised up to 20 GHz using RF-on-wafer measurements. They demonstrated good performance, considering the experimental nature of in-house multilayer technology and the difficulties in simulating these three-dimensional new geometries. With high resistivity substrates, the silicon components achieved virtually the same performance as their gallium arsenide counterparts. The transformers were then used in simulations of transformer-coupled HBT amplifier circuits, to demonstrate their capabilities. It was shown that these circuits present good performance compared to standard off-the shelf component circuits and are very promising for use in most multilayer MMIC applications. The structures were further used in coupling configurations, and applied in balun circuits and pushpull amplifiers. The spiral transformer coupler can operate at low frequencies without using up much chip area. In a balun configuration, the balun can compensate for coupling and phase imbalance and operates over 5 to 15 GHz. The spiral coupler does not always need multilayer processing, so the balun may be

  3. Automated Design Tools for Integrated Mixed-Signal Microsystems (NeoCAD)

    National Research Council Canada - National Science Library

    Petre, P; Visher, J; Shringarpure, R; Valley, F; Swaminathan, M

    2005-01-01

    Automated design tools and integrated design flow methodologies were developed that demonstrated more than an order- of-magnitude reduction in cycle time and cost for mixed signal (digital/analoglRF...

  4. Risk Informed Design Using Integrated Vehicle Rapid Assessment Tools

    Data.gov (United States)

    National Aeronautics and Space Administration — A successful proof of concept was performed in FY 2012 integrating the Envision tool for parametric estimates of vehicle mass and the Rapid Response Risk Assessment...

  5. Integrated design of intelligent surveillance systems and their user interface

    NARCIS (Netherlands)

    Toet, A.

    2005-01-01

    Modern complex surveillance systems consisting of multiple and heterogeneous sensors, automatic information registration and data analysis techniques, and decision support tools should provide the human operator an integrated, transparent and easily comprehensible view of the surveyed scene.

  6. Concise Review: Organ Engineering: Design, Technology, and Integration

    NARCIS (Netherlands)

    Kaushik, G.; Leijten, Jeroen Christianus Hermanus; Khademhosseini, A.

    Engineering complex tissues and whole organs has the potential to dramatically impact translational medicine in several avenues. Organ engineering is a discipline that integrates biological knowledge of embryological development, anatomy, physiology, and cellular interactions with enabling

  7. Advanced integrated spectrometer designs for miniaturized optical coherence tomography systems

    NARCIS (Netherlands)

    Akça, B.I.; Povazay, B.; Chang, Lantian; Alex, A.; Worhoff, Kerstin; de Ridder, R.M.; Drexler, W.; Pollnau, Markus

    Optical coherence tomography (OCT) has enabled clinical applications that revolutionized in vivo medical diagnostics. Nevertheless, its current limitations owing to cost, size, complexity, and the need for accurate alignment must be overcome by radically novel approaches. Exploiting integrated

  8. Microwave integrated circuit mask design, using computer aided microfilm techniques

    Energy Technology Data Exchange (ETDEWEB)

    Reymond, J.M.; Batliwala, E.R.; Ajose, S.O.

    1977-01-01

    This paper examines the possibility of using a computer interfaced with a precision film C.R.T. information retrieval system, to produce photomasks suitable for the production of microwave integrated circuits.

  9. System integration design in MEMS – A case study of ...

    Indian Academy of Sciences (India)

    solutions in MEMS technology is very much felt that combine single chip integration .... chip are being used for temperature compensation and to balance the bridge configuration. ..... to the offset voltage, which reduces the span of the sensor.

  10. Integrated Design for Geoscience Education with Upward Bound Students

    Science.gov (United States)

    Cartwright, T. J.; Hogsett, M.; Ensign, T. I.; Hemler, D.

    2009-05-01

    Capturing the interest of our students is imperative to expand the conduit of future Earth scientists in the United States. According to the Rising Above the Gathering Storm report (2005), we must increase America's talent pool by improving K-12 mathematics and science education. Geoscience education is uniquely suited to accomplish this goal, as we have become acutely aware of our sensitivity to the destructive forces of nature. The educational community must take advantage of this heightened awareness to educate our students and ensure the next generation rebuilds the scientific and technological base on which our society rests. In response to these concerns, the National Science Foundation advocates initiatives in Geoscience Education such as IDGE (Integrated Design for Geoscience Education), which is an inquiry-based geoscience program for Upward Bound (UB) students at Marshall University in Huntington, West Virginia. The UB program targets low-income under-represented students for a summer academic-enrichment program. IDGE builds on the mission of UB by encouraging underprivileged students to investigate science and scientific careers. During the two year project, high school students participated in an Environmental Inquiry course utilizing GLOBE program materials and on-line learning modules developed by geoscience specialists in land cover, soils, hydrology, phenology, and meteorology. Students continued to an advanced course which required IDGE students to collaborate with GLOBE students from Costa Rica. The culmination of this project was an educational expedition in Costa Rica to complete ecological field studies, providing first-hand knowledge of the international responsibility we have as scientists and citizens of our planet. IDGE was designed to continuously serve educators and students. By coordinating initiatives with GLOBE headquarters and the GLOBE country community, IDGE's efforts have yielded multiple ways in which to optimize positive

  11. Integrated Design of Semi-Displacement Patrol Crafts

    National Research Council Canada - National Science Library

    Gillespy, Andrew J

    2008-01-01

    ... of any one change on the entire system. The initial design of smaller patrol craft is especially difficult due to the lack of design tools able to deal with ships of small size operating in the semi-planing region...

  12. Improving Building Performance through Integrating Constructability in the Design Process

    OpenAIRE

    Ezzat Othman, Ayman Ahmed

    2011-01-01

    The traditional procurment approaches commonly adopted in construction projects and the involvement of multitude of various project participants with diverse objectives, skills and interests tended to separate design from construction.This separation obstructs contractors from providing designers with construction feedback and suggestions for design improvement, which ultimately hampers the improvement of building performance. Because of the importance of the design phase and the vit...

  13. Design and Potential of Non-Integrating Lentiviral Vectors

    Directory of Open Access Journals (Sweden)

    Aaron Shaw

    2014-01-01

    Full Text Available Lentiviral vectors have demonstrated promising results in clinical trials that target cells of the hematopoietic system. For these applications, they are the vectors of choice since they provide stable integration into cells that will undergo extensive expansion in vivo. Unfortunately, integration can have unintended consequences including dysregulated cell growth. Therefore, lentiviral vectors that do not integrate are predicted to have a safer profile compared to integrating vectors and should be considered for applications where transient expression is required or for sustained episomal expression such as in quiescent cells. In this review, the system for generating lentiviral vectors will be described and used to illustrate how alterations in the viral integrase or vector Long Terminal Repeats have been used to generate vectors that lack the ability to integrate. In addition to their safety advantages, these non-integrating lentiviral vectors can be used when persistent expression would have adverse consequences. Vectors are currently in development for use in vaccinations, cancer therapy, site-directed gene insertions, gene disruption strategies, and cell reprogramming. Preclinical work will be described that illustrates the potential of this unique vector system in human gene therapy.

  14. Interactive urban design using integrated planning requirements control

    NARCIS (Netherlands)

    Vries, de B.; Tabak, V.; Achten, H.H.

    2005-01-01

    Urban planning and urban design are separated disciplines. As a consequence, there is hardly any feedback from the urban design process to the urban planning process. To improve interaction between these two, an interactive urban design (IUD) tool has been developed. The tool is implemented in a

  15. Enhancing user experience design with an integrated storytelling method

    NARCIS (Netherlands)

    Peng, Qiong; Matterns, Jean Bernard; Marcus, A.

    2016-01-01

    Storytelling has been known as a service design method and been used broadly not only in service design but also in the context of user experience design. However, practitioners cannot yet fully appreciate the benefits of storytelling, and often confuse storytelling with storyboarding and scenarios.

  16. Integration of educational methods and physical settings: Design ...

    African Journals Online (AJOL)

    ... setting without having an architectural background. The theoretical framework of the research allows designers to consider key features and users' possible activities in High/ Scope settings and shape their designs accordingly. Keywords: daily activity; design; High/Scope education; interior space; teaching method ...

  17. Meta 2: Lingua Franca Design and Integration Language

    Science.gov (United States)

    2011-08-01

    Banca Intesa/San Paolo. He was the founder and Scientific Director of the Project on Advanced Research on Architectures and Design of Electronic...34Platform-Based Design and Frameworks: Metropolis and Metro II" in Model-Based Design for Embedded Systems, Boca Raton, Fl: CRC Press , Taylor and

  18. Inclusive E-Learning - Towards an Integrated System Design.

    Science.gov (United States)

    Patzer, Yasmin; Pinkwart, Niels

    2017-01-01

    At first sight there seem to be issues combining technical accessibility guidelines and educational needs when designing inclusive E-Learning. Furthermore Universal Design for Learning seems to contradict individualization. In this paper we address both issues with an inclusive E-Learning design for the LAYA system, which targets disabled and non-disabled learners.

  19. Product integrated PV: the future is design and styling

    NARCIS (Netherlands)

    Eggink, Wouter; Reinders, Angelina H.M.E.

    2016-01-01

    In this paper we explore how PV powered products have been designed in the past. For this purpose we have drawn a historical time line of the design features of PV powered products in the context of main stream design and styling. Our time frame is 1970 till 2016, focusing in first instance on

  20. Design of a semi-custom integrated circuit for the SLAC SLC timing control system

    International Nuclear Information System (INIS)

    Linstadt, E.

    1984-10-01

    A semi-custom (gate array) integrated circuit has been designed for use in the SLAC Linear Collider timing and control system. The design process and SLAC's experiences during the phases of the design cycle are described. Issues concerning the partitioning of the design into semi-custom and standard components are discussed. Functional descriptions of the semi-custom integrated circuit and the timing module in which it is used are given

  1. Quantitative Experimental Determination of Primer-Dimer Formation Risk by Free-Solution Conjugate Electrophoresis

    Science.gov (United States)

    Desmarais, Samantha M.; Leitner, Thomas; Barron, Annelise E.

    2012-01-01

    DNA barcodes are short, unique ssDNA primers that “mark” individual biomolecules. To gain better understanding of biophysical parameters constraining primer-dimer formation between primers that incorporate barcode sequences, we have developed a capillary electrophoresis method that utilizes drag-tag-DNA conjugates to quantify dimerization risk between primer-barcode pairs. Results obtained with this unique free-solution conjugate electrophoresis (FSCE) approach are useful as quantitatively precise input data to parameterize computation models of dimerization risk. A set of fluorescently labeled, model primer-barcode conjugates were designed with complementary regions of differing lengths to quantify heterodimerization as a function of temperature. Primer-dimer cases comprised two 30-mer primers, one of which was covalently conjugated to a lab-made, chemically synthesized poly-N-methoxyethylglycine drag-tag, which reduced electrophoretic mobility of ssDNA to distinguish it from ds primer-dimers. The drag-tags also provided a shift in mobility for the dsDNA species, which allowed us to quantitate primer-dimer formation. In the experimental studies, pairs of oligonucleotide primer-barcodes with fully or partially complementary sequences were annealed, and then separated by free-solution conjugate CE at different temperatures, to assess effects on primer-dimer formation. When less than 30 out of 30 basepairs were bonded, dimerization was inversely correlated to temperature. Dimerization occurred when more than 15 consecutive basepairs formed, yet non-consecutive basepairs did not create stable dimers even when 20 out of 30 possible basepairs bonded. The use of free-solution electrophoresis in combination with a peptoid drag-tag and different fluorophores enabled precise separation of short DNA fragments to establish a new mobility shift assay for detection of primer-dimer formation. PMID:22331820

  2. Optimal pcr primers for rapid and accurate detection of Aspergillus flavus isolates.

    Science.gov (United States)

    Al-Shuhaib, Mohammed Baqur S; Albakri, Ali H; Alwan, Sabah H; Almandil, Noor B; AbdulAzeez, Sayed; Borgio, J Francis

    2018-03-01

    Aspergillus flavus is among the most devastating opportunistic pathogens of several food crops including rice, due to its high production of carcinogenic aflatoxins. The presence of these organisms in economically important rice strip farming is a serious food safety concern. Several polymerase chain reaction (PCR) primers have been designed to detect this species; however, a comparative assessment of their accuracy has not been conducted. This study aims to identify the optimal diagnostic PCR primers for the identification of A. flavus, among widely available primers. We isolated 122 A. flavus native isolates from randomly collected rice strips (N = 300). We identified 109 isolates to the genus level using universal fungal PCR primer pairs. Nine pairs of primers were examined for their PCR diagnostic specificity on the 109 isolates. FLA PCR was found to be the optimal PCR primer pair for specific identification of the native isolates, over aflP(1), aflM, aflA, aflD, aflP(3), aflP(2), and aflR. The PEP primer pair was found to be the most unsuitable for A. flavus identification. In conclusion, the present study indicates the powerful specificity of the FLA PCR primer over other commonly available diagnostic primers for accurate, rapid, and large-scale identification of A. flavus native isolates. This study provides the first simple, practical comparative guide to PCR-based screening of A. flavus infection in rice strips. Copyright © 2018 Elsevier Ltd. All rights reserved.

  3. Research and Application of Integration Design Environment Faced to CSCD

    Institute of Scientific and Technical Information of China (English)

    ZHAO Han; LI Yanfeng; DONG Yude

    2006-01-01

    Computer supported collaborative design(CSCD) technology has been applied extensively with intensive market competition. The key technologies and problems of CSCD are analyzed and a CSCD design frame faced to product design is established. Then a CSCD system faced to radar key components is founded with Pro/INTRALINK software and re-exploiting technology. Some key processes are also designed, such as database management, workflow programming, information communication, file release, conflict identification and safety management. These will provide a reference for constructing a cooperative design environment.

  4. A database of PCR primers for the chloroplast genomes of higher plants

    Science.gov (United States)

    Heinze, Berthold

    2007-01-01

    Background Chloroplast genomes evolve slowly and many primers for PCR amplification and analysis of chloroplast sequences can be used across a wide array of genera. In some cases 'universal' primers have been designed for the purpose of working across species boundaries. However, the essential information on these primer sequences is scattered throughout the literature. Results A database is presented here which assembles published primer information for chloroplast DNA. Additional primers were designed to fill gaps where little or no primer information could be found. Amplicons are either the genes themselves (typically useful in studies of sequence variation in higher-order phylogeny) or they are spacers, introns, and intergenic regions (for studies of phylogeographic patterns within and among species). The current list of 'generic' primers consists of more than 700 sequences. Wherever possible, we give the locations of the primers in the thirteen fully sequenced chloroplast genomes (Nicotiana tabacum, Atropa belladonna, Spinacia oleracea, Arabidopsis thaliana, Populus trichocarpa, Oryza sativa, Pinus thunbergii, Marchantia polymorpha, Zea mays, Oenothera elata, Acorus calamus, Eucalyptus globulus, Medicago trunculata). Conclusion The database described here is designed to serve as a resource for researchers who are venturing into the study of poorly described chloroplast genomes, whether for large- or small-scale DNA sequencing projects, to study molecular variation or to investigate chloroplast evolution. PMID:17326828

  5. A database of PCR primers for the chloroplast genomes of higher plants

    Directory of Open Access Journals (Sweden)

    Heinze Berthold

    2007-02-01

    Full Text Available Abstract Background Chloroplast genomes evolve slowly and many primers for PCR amplification and analysis of chloroplast sequences can be used across a wide array of genera. In some cases 'universal' primers have been designed for the purpose of working across species boundaries. However, the essential information on these primer sequences is scattered throughout the literature. Results A database is presented here which assembles published primer information for chloroplast DNA. Additional primers were designed to fill gaps where little or no primer information could be found. Amplicons are either the genes themselves (typically useful in studies of sequence variation in higher-order phylogeny or they are spacers, introns, and intergenic regions (for studies of phylogeographic patterns within and among species. The current list of 'generic' primers consists of more than 700 sequences. Wherever possible, we give the locations of the primers in the thirteen fully sequenced chloroplast genomes (Nicotiana tabacum, Atropa belladonna, Spinacia oleracea, Arabidopsis thaliana, Populus trichocarpa, Oryza sativa, Pinus thunbergii, Marchantia polymorpha, Zea mays, Oenothera elata, Acorus calamus, Eucalyptus globulus, Medicago trunculata. Conclusion The database described here is designed to serve as a resource for researchers who are venturing into the study of poorly described chloroplast genomes, whether for large- or small-scale DNA sequencing projects, to study molecular variation or to investigate chloroplast evolution.

  6. Analog Integrated Circuit Design for Spike Time Dependent Encoder and Reservoir in Reservoir Computing Processors

    Science.gov (United States)

    2018-01-01

    HAS BEEN REVIEWED AND IS APPROVED FOR PUBLICATION IN ACCORDANCE WITH ASSIGNED DISTRIBUTION STATEMENT. FOR THE CHIEF ENGINEER : / S / / S...bridged high-performance computing, nanotechnology , and integrated circuits & systems. 15. SUBJECT TERMS neuromorphic computing, neuron design, spike...multidisciplinary effort encompassed high-performance computing, nanotechnology , integrated circuits, and integrated systems. The project’s architecture was

  7. Ultrafast all-optical integrator based on a fiber Bragg grating: proposal and design.

    Science.gov (United States)

    Preciado, Miguel A; Muriel, Miguel A

    2008-06-15

    We demonstrate a simple technique for the implementation of an all-optical integrator based on a uniform-period fiber Bragg grating (FBG) in reflection that is designed to present a decreasing exponential impulse response. The proposed FBG integrator is readily feasible and can perform close to ideal integration of few-picosecond and subpicosecond pulses.

  8. A primer of multivariate statistics

    CERN Document Server

    Harris, Richard J

    2014-01-01

    Drawing upon more than 30 years of experience in working with statistics, Dr. Richard J. Harris has updated A Primer of Multivariate Statistics to provide a model of balance between how-to and why. This classic text covers multivariate techniques with a taste of latent variable approaches. Throughout the book there is a focus on the importance of describing and testing one's interpretations of the emergent variables that are produced by multivariate analysis. This edition retains its conversational writing style while focusing on classical techniques. The book gives the reader a feel for why

  9. Packaging for consumer electronic products : The need for integrating design and engineering

    NARCIS (Netherlands)

    Wever, R.; Boks, C.; Stevels, A.

    2008-01-01

    From the perspective of a multinational corporation producing durable consumer goods sustainable packaging is packaging that fulfils the right functionalities in the most efficient way. In order to achieve this, an integral design process is required. Such an integral approach to the design of

  10. 3D Integration of MEMS and IC: Design, technology and simulations

    OpenAIRE

    Schjølberg-Henriksen, Kari

    2009-01-01

    * 3D integration: Opportunities and trends* e-CUBES: Tire pressure monitoring system (TPMS)* Package design including thermo-mechanical modeling* Technology development* Sensor packaging concept* Gold stud bump bonding* Device characterization and testing* Summary and outlook 3D Integration of MEMS and IC: Design, technology and simulations

  11. Conditions for the Successful Implementation of Teacher Educator Design Teams for ICT Integration: A Delphi Study

    Science.gov (United States)

    Becuwe, Heleen; Roblin, Natalie Pareja; Tondeur, Jo; Thys, Jeroen; Castelein, Els; Voogt, Joke

    2017-01-01

    Teacher educators often struggle to model effective integration of technology. Several studies suggest that the involvement of teacher educators in collaborative design is effective in developing the competences necessary for integrating information and communication technology (ICT) in teaching. In a teacher educator design team (TeDT), two or…

  12. An approach to integrated design based componet software and OLE-technology

    DEFF Research Database (Denmark)

    Bagger-Petersen, Susanne C; Emborg, Jørgen; Andersen, Tom

    1996-01-01

    The paper reports on a prototype developed as to demonstrate the (dis)abilities of the OLE-standard to integrate different design-applications to a CAD-syste.......The paper reports on a prototype developed as to demonstrate the (dis)abilities of the OLE-standard to integrate different design-applications to a CAD-syste....

  13. Integrated Computer-aided Framework for Sustainable Chemical Product Design and Evaluation

    DEFF Research Database (Denmark)

    Kalakul, Sawitree; Cignitti, Stefano; Zhang, Lei

    2016-01-01

    This work proposes an integrated model-based framework for chemical product design and evaluation based on which the software, VPPD-Lab (The Virtual Product-Process Design Laboratory) has been developed. The framework allows the following options: (1) design a product using design templates...

  14. Design of Smart Multi-Functional Integrated Aviation Photoelectric Payload

    Science.gov (United States)

    Zhang, X.

    2018-04-01

    To coordinate with the small UAV at reconnaissance mission, we've developed a smart multi-functional integrated aviation photoelectric payload. The payload weighs only 1kg, and has a two-axis stabilized platform with visible task payload, infrared task payload, laser pointers and video tracker. The photoelectric payload could complete the reconnaissance tasks above the target area (including visible and infrared). Because of its light weight, small size, full-featured, high integrated, the constraints of the UAV platform carrying the payload will be reduced a lot, which helps the payload suit for more extensive using occasions. So all users of this type of smart multi-functional integrated aviation photoelectric payload will do better works on completion of the ground to better pinpoint targets, artillery calibration, assessment of observe strike damage, customs officials and other tasks.

  15. Design of Sustainable Blended Products using an Integrated Methodology

    DEFF Research Database (Denmark)

    Yunus, Nor Alafiza Binti; Gernaey, Krist; Woodley, John

    2013-01-01

    This paper presents a systematic methodology for designing blended products consisting of three stages; product design, process identification and experimental verification. The product design stage is considered in this paper. The objective of this stage is to screen and select suitable chemicals...... to be used as building blocks in the mixture design, and then to propose the blend formulations that fulfill the desired product attributes. The result is a set of blends that match the constraints, the compositions, values of the target properties and information about their miscibility. The methodology has...... been applied to design several blended products. A case study on design of blended lubricants is highlighted. The objective is to identify blended products that satisfy the product attributes with at least similar or better performance compared to conventional products....

  16. Integrated topology and shape optimization in structural design

    Science.gov (United States)

    Bremicker, M.; Chirehdast, M.; Kikuchi, N.; Papalambros, P. Y.

    1990-01-01

    Structural optimization procedures usually start from a given design topology and vary its proportions or boundary shapes to achieve optimality under various constraints. Two different categories of structural optimization are distinguished in the literature, namely sizing and shape optimization. A major restriction in both cases is that the design topology is considered fixed and given. Questions concerning the general layout of a design (such as whether a truss or a solid structure should be used) as well as more detailed topology features (e.g., the number and connectivities of bars in a truss or the number of holes in a solid) have to be resolved by design experience before formulating the structural optimization model. Design quality of an optimized structure still depends strongly on engineering intuition. This article presents a novel approach for initiating formal structural optimization at an earlier stage, where the design topology is rigorously generated in addition to selecting shape and size dimensions. A three-phase design process is discussed: an optimal initial topology is created by a homogenization method as a gray level image, which is then transformed to a realizable design using computer vision techniques; this design is then parameterized and treated in detail by sizing and shape optimization. A fully automated process is described for trusses. Optimization of two dimensional solid structures is also discussed. Several application-oriented examples illustrate the usefulness of the proposed methodology.

  17. Secure Voice System Integrated Conferencing Analysis and Interoperation Design.

    Science.gov (United States)

    1987-02-17

    8217 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . r~ . DEFENSE~~~ ~ ~ COMNCAIN ENIERNGCNE 4f* ’co.t. SECUE VOCE SSTE COMUCTSCECSROAION CNEOPRATIO DESIGN4C-0 UNCLASSIFIED

  18. Combining Critical Reflection and Design Thinking to Develop Integrative Learners

    Science.gov (United States)

    Welsh, M. Ann; Dehler, Gordon E.

    2013-01-01

    In this article, we argue for advancing grounded curricula, which explicitly link theory and pedagogy, and executing them in authentic and multidisciplinary settings as a means to facilitate student growth into integrative learners. We describe the development of a student-centered learning experience that combines elements of critical management…

  19. Using Research to Design Integrated Education and Training Programs

    Science.gov (United States)

    Pappalardo, Michele; Schaffer, William R.

    2016-01-01

    With the passage of the Workforce Innovation and Opportunity Act (WIOA) of 2014, Northampton Community College began the creation of Integrated Education and Training (IE&T) programs in October 2015. After a needs assessment was conducted with the partners, programs were created to address the needs in the hospitality and healthcare sectors.…

  20. Design of model based LQG control for integrated building systems

    NARCIS (Netherlands)

    Yahiaoui, A.; Hensen, J.L.M.; Soethout, L.L.; Paassen, van A.H.C.

    2006-01-01

    The automation of the operation of integrated building systems requires using modern control techniques to enhance the quality of the building indoor environments. This paper describes the theatrical base and practical application of an optimal dynamic regulator using modelbased Linear Quadratic