WorldWideScience

Sample records for integrated biorefinery research

  1. Sustainability considerations for integrated biorefineries.

    Science.gov (United States)

    Azapagic, Adisa

    2014-01-01

    Integrated biorefineries have the potential to contribute towards sustainable production of transportation fuels, energy, and chemicals. However, because there are currently no commercial biorefining plants in operation, it is not clear how sustainable they really are. This paper sets out to examine key issues associated with biorefining that should be considered carefully along the whole supply chain to ensure sustainable development of the sector. Copyright © 2013 Elsevier Ltd. All rights reserved.

  2. Sapphire Energy - Integrated Algal Biorefinery

    Energy Technology Data Exchange (ETDEWEB)

    White, Rebecca L. [Sapphire Energy, Inc., Columbus, NM (United States). Columbus Algal Biomass Farm; Tyler, Mike [Sapphire Energy, Inc., San Diego, CA (United States)

    2015-07-22

    Sapphire Energy, Inc. (SEI) is a leader in large-scale photosynthetic algal biomass production, with a strongly cohesive research, development, and operations program. SEI takes a multidiscipline approach to integrate lab-based strain selection, cultivation and harvest and production scale, and extraction for the production of Green Crude oil, a drop in replacement for traditional crude oil.. SEI’s technical accomplishments since 2007 have produced a multifunctional platform that can address needs for fuel, feed, and other higher value products. Figure 1 outlines SEI’s commercialization process, including Green Crude production and refinement to drop in fuel replacements. The large scale algal biomass production facility, the SEI Integrated Algal Biorefinery (IABR), was built in Luna County near Columbus, New Mexico (see fig 2). The extraction unit was located at the existing SEI facility in Las Cruces, New Mexico, approximately 95 miles from the IABR. The IABR facility was constructed on time and on budget, and the extraction unit expansion to accommodate the biomass output from the IABR was completed in October 2012. The IABR facility uses open pond cultivation with a proprietary harvesting method to produce algal biomass; this biomass is then shipped to the extraction facility for conversion to Green Crude. The operation of the IABR and the extraction facilities has demonstrated the critical integration of traditional agricultural techniques with algae cultivation knowledge for algal biomass production, and the successful conversion of the biomass to Green Crude. All primary unit operations are de-risked, and at a scale suitable for process demonstration. The results are stable, reliable, and long-term cultivation of strains for year round algal biomass production. From June 2012 to November 2014, the IABR and extraction facilities produced 524 metric tons (MT) of biomass (on a dry weight basis), and 2,587 gallons of Green Crude. Additionally, the IABR

  3. Evaluating municipal energy efficiency in biorefinery integration

    International Nuclear Information System (INIS)

    Haikonen, Turo; Tuomaala, Mari; Holmberg, Henrik; Ahtila, Pekka

    2013-01-01

    In this study biomass-based energy production was introduced to an urban city area of Helsinki, Finland. The study compared two cases in integration with a municipality: (1) biomass fuelled small-scale CHP (combined heat and power)-plant and (2) a biorefinery. The comparison was made according to primary energy consumption, primary energy factors, CO 2 (carbon dioxide) emissions and the price of produced biowax. It was also studied how results are influenced by different assumptions. The results showed that the primary energy consumption and CO 2 emissions were higher in the biorefinery case in absolute amounts as more products i.e. biowax was produced. The results indicated the primary energy factors were almost the same for both cases. Additionally, the primary energy use was very low for district heat and electricity produced in the biorefinery, when the primary energy use of the biorefinery was allocated only to the biowax. The sensitivity analysis of biowax pricing showed that a biorefinery is a competitive alternative for a CHP-plant if the prices of biomass and market electricity are low and the price of CO 2 allowance is high. In terms of overall energy efficiency comparison, the comparison cannot be properly completed, because of the different end-products of the plants. - Highlights: • Primary energy consumption and CO 2 emissions in a municipality are studied. • Energy production in a biorefinery is compared to a conventional CHP-plant. • In the biorefinery CO 2 emission per produced energy unit (CO 2 /MWh) is the lowest. • The CHP-case benefits from low primary energy consumption and electricity demand. • More than one energy efficiency figure needs to be considered in analyses

  4. 2009 Integrated Biorefinery Platform Review Report

    Energy Technology Data Exchange (ETDEWEB)

    Ferrell, John [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2009-12-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the U.S. Department of Energy Biomass Program‘s Integrated Biorefinery (IBR) platform review meeting, held on February 18–19, 2009, at the Westin National Harbor, National Harbor, Maryland.

  5. Biorefineries to integrate fuel, energy and chemical production processes

    Directory of Open Access Journals (Sweden)

    Enrica Bargiacchi

    2007-12-01

    Full Text Available The world of renewable energies is in fast evolution and arouses political and public interests, especially as an opportunity to boost environmental sustainability by mitigation of greenhouse gas emissions. This work aims at examining the possibilities related to the development of biorefineries, where biomass conversion processes to produce biofuels, electricity and biochemicals are integrated. Particular interest is given to the production processes of biodiesel, bioethanol and biogas, for which present world situation, problems, and perspectives are drawn. Potential areas for agronomic and biotech researches are also discussed. Producing biomass for biorefinery processing will eventually lead to maximize yields, in the non food agriculture.

  6. Biorefinery and Hydrogen Fuel Cell Research

    Energy Technology Data Exchange (ETDEWEB)

    K.C. Das; Thomas T. Adams; Mark A. Eiteman; John Stickney; Joy Doran Peterson; James R. Kastner; Sudhagar Mani; Ryan Adolphson

    2012-06-12

    In this project we focused on several aspects of technology development that advances the formation of an integrated biorefinery. These focus areas include: [1] establishment of pyrolysis processing systems and characterization of the product oils for fuel applications, including engine testing of a preferred product and its pro forma economic analysis; [2] extraction of sugars through a novel hotwater extaction process, and the development of levoglucosan (a pyrolysis BioOil intermediate); [3] identification and testing of the use of biochar, the coproduct from pyrolysis, for soil applications; [4] developments in methods of atomic layer epitaxy (for efficient development of coatings as in fuel cells); [5] advancement in fermentation of lignocellulosics, [6] development of algal biomass as a potential substrate for the biorefinery, and [7] development of catalysts from coproducts. These advancements are intended to provide a diverse set of product choices within the biorefinery, thus improving the cost effectiveness of the system. Technical effectiveness was demonstrated in the pyrolysis biooil based diesel fuel supplement, sugar extraction from lignocelluose, use of biochar, production of algal biomass in wastewaters, and the development of catalysts. Economic feasibility of algal biomass production systems seems attractive, relative to the other options. However, further optimization in all paths, and testing/demonstration at larger scales are required to fully understand the economic viabilities. The various coproducts provide a clear picture that multiple streams of value can be generated within an integrated biorefinery, and these include fuels and products.

  7. Biorefinery and Carbon Cycling Research Project

    Energy Technology Data Exchange (ETDEWEB)

    Das, K. C., Adams; Thomas, T; Eiteman, Mark A; Kastner, James R; Mani, Sudhagar; Adolphson, Ryan

    2012-06-08

    In this project we focused on several aspects of technology development that advances the formation of an integrated biorefinery. These focus areas include: [ 1] pretreatment of biomass to enhance quality of products from thermochemical conversion; [2] characterization of and development of coproduct uses; [3] advancement in fermentation of lignocellulosics and particularly C5 and C6 sugars simultaneously, and [ 4] development of algal biomass as a potential substrate for the biorefinery. These advancements are intended to provide a diverse set of product choices within the biorefinery, thus improving the cost effectiveness of the system. Technical effectiveness was demonstrated in the thermochemical product quality in the form of lower tar production, simultaneous of use of multiple sugars in fermentation, use ofbiochar in environmental (ammonia adsorption) and agricultural applications, and production of algal biomass in wastewaters. Economic feasibility of algal biomass production systems seems attractive, relative to the other options. However, further optimization in all paths, and testing/demonstration at larger scales are required to fully understand the economic viabilities. The coproducts provide a clear picture that multiple streams of value can be generated within an integrated biorefinery, and these include fuels and products.

  8. Integrated Biorefinery for Biofuels Production

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Gabriel [Society for Energy and Environmental Research (SEER), New York, NY (United States)

    2011-09-02

    This project has focused on very low grade fats, oil and greases found in municipal, commercial and industrial facilities around the country. These wastes are often disposed in landfills, wastewater treatment plants or farm fields or are blended illegally into animal feeds. Using any of these waste fatty materials that are unfit for human or animal nutrition as a clean alternative fuel makes good sense. This project defines the aforementioned wastes in terms of quality and prevalence in the US, then builds on specific promising pathways for utilizing these carbon neutral wastes. These pathways are discussed and researched at bench-scale, and in one instance, at pilot-scale. The three primary pathways are as follows: The production of Renewable Diesel Oil (RDO) as a stand-alone fuel or blended with standard distillate or residual hydrocarbons; The production of RDO as a platform for the further manufacture of Biodiesel utilizing acid esterification; The production of RDO as a platform for the manufacture of an ASTM Diesel Fuel using one or more catalysts to effect a decarboxylation of the carboxylics present in RDO This study shows that Biodiesel and ASTM Diesel produced at bench-scale (utilizing RDO made from grease trap waste as an input) could not meet industry specifications utilizing the technologies that were selected by the investigators. Details of these investigations are discussed in this report and will hopefully provide a starting point for other researchers interested in these pathways in future studies. Although results were inconclusive in finding ways to utilize RDO technology, in effect, as a pretreatment for commonly discussed technologies such as Biodiesel and ASTM Diesel, this study does shed light on the properties, performance and cost of utilizing waste greases directly as a retail liquid fuel (RDO). The utilization as a retail RDO as a boiler fuel, or for other such applications, is the most important finding of the study.

  9. Development of hemicelluloses biorefineries for integration into kraft pulp mills

    Science.gov (United States)

    Ajao, Olumoye Abiodun

    implementation were designed to lower the energy consumption. The feasibility of the energy and material integration of the biorefinery was demonstrated and the utility demands can be met by the reference mill. A techno-economic evaluation of the developed process showed that it is economically feasible and a return on capital employed (ROCE) as high as 36 % can be obtained. The ethanol biorefinery process was shown to have a lower thermal energy requirement than the furfural process and can also be successfully integrated with the receptor mill. In the last phase of this research, the guideline for the implementation of hemicellulosic biorefineries in Canadian pulp and paper mills are proposed. It included analyses of the modifications required for different types of Kraft pulping processes prior to their conversion into a biorefinery, energy optimization approaches to address the increased energy demand after integration, factors that must be considered during bioproducts selection and types of collaboration that can be used to reduce risk and lower investment.

  10. UNCERTAINTY IN THE PROCESS INTEGRATION FOR THE BIOREFINERIES DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Meilyn González Cortés

    2015-07-01

    Full Text Available This paper presents how the design approaches with high level of flexibility can reduce the additional costs of the strategies that apply overdesign factors to consider parameters with uncertainty that impact on the economic feasibility of a project. The elements with associate uncertainties and that are important in the configurations of the process integration under a biorefinery scheme are: raw material, raw material technologies of conversion, and variety of products that can be obtained. From the analysis it is obtained that in the raw materials and products with potentialities in a biorefinery scheme, there are external uncertainties such as availability, demands and prices in the market. Those external uncertainties can determine their impact on the biorefinery and also in the product prices we can find minimum and maximum limits that can be identified in intervals which should be considered for the project economic evaluation and the sensibility analysis due to varied conditions.

  11. Biomass Program 2007 Peer Review - Integrated Biorefinery Platform Summary

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-10-27

    This document discloses the comments provided by a review panel at the U.S. Department of Energy Office of the Biomass Program Peer Review held on November 15-16, 2007 in Baltimore, MD and the Integrated Biorefinery Platform Review held on August 13-15, 2007 in Golden, Colorado.

  12. ClearFuels-Rentech Integrated Biorefinery Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Pearson, Joshua [Project Director

    2014-02-26

    The project Final Report describes the validation of the performance of the integration of two technologies that were proven individually on a pilot scale and were demonstrated as a pilot scale integrated biorefinery. The integrated technologies were a larger scale ClearFuels’ (CF) advanced flexible biomass to syngas thermochemical high efficiency hydrothermal reformer (HEHTR) technology with Rentech’s (RTK) existing synthetic gas to liquids (GTL) technology.

  13. Biorefineries--multi product processes.

    Science.gov (United States)

    Kamm, B; Kamm, M

    2007-01-01

    The development of biorefineries represents the key for access to an integrated production of food, feed, chemicals, materials, goods, and fuels of the future [1]. Biorefineries combine the necessary technologies of the biogenic raw materials with those of intermediates and final products. The main focus is directed at the precursors carbohydrates, lignin, oils, and proteins and the combination between biotechnological and chemical conversion of substances. Currently the lignocellulosic feedstock biorefinery, green biorefinery, whole corn biorefinery, and the so-called two-platform concept are favored in research, development, and industrial implementation.

  14. Assessing the environmental sustainability of ethanol from integrated biorefineries.

    Science.gov (United States)

    Falano, Temitope; Jeswani, Harish K; Azapagic, Adisa

    2014-06-01

    This paper considers the life cycle environmental sustainability of ethanol produced in integrated biorefineries together with chemicals and energy. Four types of second-generation feedstocks are considered: wheat straw, forest residue, poplar, and miscanthus. Seven out of 11 environmental impacts from ethanol are negative, including greenhouse gas (GHG) emissions, when the system is credited for the co-products, indicating environmental savings. Ethanol from poplar is the best and straw the worst option for most impacts. Land use change from forest to miscanthus increases the GHG emissions several-fold. For poplar, the effect is opposite: converting grassland to forest reduces the emissions by three-fold. Compared to fossil and first-generation ethanol, ethanol from integrated biorefineries is more sustainable for most impacts, with the exception of wheat straw. Pure ethanol saves up to 87% of GHG emissions compared to petrol per MJ of fuel. However, for the current 5% ethanol-petrol blends, the savings are much smaller (biorefineries to the reduction of GHG emissions will be insignificant. Yet, higher ethanol blends would lead to an increase in some impacts, notably terrestrial and freshwater toxicity as well as eutrophication for some feedstocks. © 2014 The Authors. Biotechnology Journal published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

  15. New Sustainable Model of Biorefineries: Biofactories and Challenges of Integrating Bio- and Solar Refineries.

    Science.gov (United States)

    Abate, Salvatore; Lanzafame, Paola; Perathoner, Siglinda; Centi, Gabriele

    2015-09-07

    The new scenario for sustainable (low-carbon) chemical and energy production drives the development of new biorefinery concepts (indicated as biofactories) with chemical production at the core, but flexible and small-scale production. An important element is also the integration of solar energy and CO2 use within biobased production. This concept paper, after shortly introducing the motivation and recent trends in this area, particularly at the industrial scale, and some of the possible models (olefin and intermediate/high-added-value chemicals production), discusses the opportunities and needs for research to address the challenge of integrating bio- and solar refineries. Aspects discussed regard the use of microalgae and CO2 valorization in biorefineries/biofactories by chemo- or biocatalysis, including possibilities for their synergetic cooperation and symbiosis, as well as integration within the agroenergy value chain. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. A novel biorefinery integration concept for lignocellulosic biomass

    International Nuclear Information System (INIS)

    Özdenkçi, Karhan; De Blasio, Cataldo; Muddassar, Hassan R.; Melin, Kristian; Oinas, Pekka; Koskinen, Jukka; Sarwar, Golam; Järvinen, Mika

    2017-01-01

    Highlights: • Wide review is provided on supply chain and biomass conversion processes. • The requirements for sustainable biorefinery are listed. • An enhanced version distributed-centralized network is proposed. • A novel hydrothermal process is proposed for biomass conversion. - Abstract: The concept of an integrated biorefinery has increasing importance regarding sustainability aspects. However, the typical concepts have techno-economic issues: limited replacement in co-processing with fossil sources and high investment costs in integration to a specific plant. These issues have directed the current investigations to supply-chain network systems. On the other hand, these studies have the scope of a specific product and/or a feedstock type. This paper proposes a novel biorefinery concept for lignocellulosic biomass: sectoral integration network and a new hydrothermal process for biomass conversion. The sectoral integration concept has the potential for sustainable production from biomass: pre-treatment at the biomass sites, regional distributed conversion of biomass from various sectors (e.g. black liquor, sawdust, straw) and centralized upgrading/separation of crude biofuels. On the other hand, the conversion processes compose the vital part of such a concept. The new conversion involves partial wet oxidation - or simultaneous dissolution with partial wet oxidation for solid biomass- followed by lignin recovery with acidification and a reactor that can perform either hydrothermal liquefaction or supercritical water gasification. The process can intake both liquid and solid biomass to produce lignin as biomaterial and syngas or bio-oil. The new concept can contribute social development of rural areas by utilizing waste as valuable raw material for the production of multiple products and reduce the net greenhouse gas emissions by replacing fossil-based production.

  17. Designing optimal bioethanol networks with purification for integrated biorefineries

    International Nuclear Information System (INIS)

    Shenoy, Akshay U.; Shenoy, Uday V.

    2014-01-01

    Highlights: • An analytical method is devised for bioethanol network integration with purification. • Minimum fresh bioethanol flow and pinch are found by the Unified Targeting Algorithm. • Optimal bioethanol networks are then synthesized by the Nearest Neighbors Algorithm. • Continuous targets and networks are developed over the purifier inlet flowrate range. • Case study of a biorefinery producing bioethanol from wheat shows large savings. - Abstract: Bioethanol networks with purification for processing pathways in integrated biorefineries are targeted and designed in this work by an analytical approach not requiring graphical constructions. The approach is based on six fundamental equations involving eight variables: two balance equations for the stream flowrate and the bioethanol load over the total network system; one equation for the above-pinch bioethanol load being picked up by the minimum fresh resource and the purified stream; and three equations for the purification unit. A solution strategy is devised by specifying the two variables associated with the purifier inlet stream. Importantly, continuous targeting is then possible over the entire purifier inlet flowrate range on deriving elegant formulae for the remaining six variables. The Unified Targeting Algorithm (UTA) is utilized to establish the minimum fresh bioethanol resource flowrate and identify the pinch purity. The fresh bioethanol resource flowrate target is shown to decrease linearly with purifier inlet flowrate provided the pinch is held by the same point. The Nearest Neighbors Algorithm (NNA) is used to methodically synthesize optimal networks matching bioethanol demands and sources. A case study of a biorefinery producing bioethanol from wheat with arabinoxylan (AX) coproduction is presented. It illustrates the versatility of the approach in generating superior practical designs with up to nearly 94% savings for integrated bioethanol networks, both with and without process

  18. Amyris, Inc. Integrated Biorefinery Project Summary Final Report - Public Version

    Energy Technology Data Exchange (ETDEWEB)

    Gray, David; Sato, Suzanne; Garcia, Fernando; Eppler, Ross; Cherry, Joel

    2014-03-12

    The Amyris pilot-scale Integrated Biorefinery (IBR) leveraged Amyris synthetic biology and process technology experience to upgrade Amyris’s existing Emeryville, California pilot plant and fermentation labs to enable development of US-based production capabilities for renewable diesel fuel and alternative chemical products. These products were derived semi-synthetically from high-impact biomass feedstocks via microbial fermentation to the 15-carbon intermediate farnesene, with subsequent chemical finishing to farnesane. The Amyris IBR team tested and provided methods for production of diesel and alternative chemical products from sweet sorghum, and other high-impact lignocellulosic feedstocks, at pilot scale. This enabled robust techno-economic analysis (TEA), regulatory approvals, and a basis for full-scale manufacturing processes and facility design.

  19. Carbon Sources for Polyhydroxyalkanoates and an Integrated Biorefinery

    Directory of Open Access Journals (Sweden)

    Guozhan Jiang

    2016-07-01

    Full Text Available Polyhydroxyalkanoates (PHAs are a group of bioplastics that have a wide range of applications. Extensive progress has been made in our understanding of PHAs’ biosynthesis, and currently, it is possible to engineer bacterial strains to produce PHAs with desired properties. The substrates for the fermentative production of PHAs are primarily derived from food-based carbon sources, raising concerns over the sustainability of their production in terms of their impact on food prices. This paper gives an overview of the current carbon sources used for PHA production and the methods used to transform these sources into fermentable forms. This allows us to identify the opportunities and restraints linked to future sustainable PHA production. Hemicellulose hydrolysates and crude glycerol are identified as two promising carbon sources for a sustainable production of PHAs. Hemicellulose hydrolysates and crude glycerol can be produced on a large scale during various second generation biofuels’ production. An integration of PHA production within a modern biorefinery is therefore proposed to produce biofuels and bioplastics simultaneously. This will create the potential to offset the production cost of biofuels and reduce the overall production cost of PHAs.

  20. Carbon Sources for Polyhydroxyalkanoates and an Integrated Biorefinery.

    Science.gov (United States)

    Jiang, Guozhan; Hill, David J; Kowalczuk, Marek; Johnston, Brian; Adamus, Grazyna; Irorere, Victor; Radecka, Iza

    2016-07-19

    Polyhydroxyalkanoates (PHAs) are a group of bioplastics that have a wide range of applications. Extensive progress has been made in our understanding of PHAs' biosynthesis, and currently, it is possible to engineer bacterial strains to produce PHAs with desired properties. The substrates for the fermentative production of PHAs are primarily derived from food-based carbon sources, raising concerns over the sustainability of their production in terms of their impact on food prices. This paper gives an overview of the current carbon sources used for PHA production and the methods used to transform these sources into fermentable forms. This allows us to identify the opportunities and restraints linked to future sustainable PHA production. Hemicellulose hydrolysates and crude glycerol are identified as two promising carbon sources for a sustainable production of PHAs. Hemicellulose hydrolysates and crude glycerol can be produced on a large scale during various second generation biofuels' production. An integration of PHA production within a modern biorefinery is therefore proposed to produce biofuels and bioplastics simultaneously. This will create the potential to offset the production cost of biofuels and reduce the overall production cost of PHAs.

  1. Waste biorefineries - integrating anaerobic digestion and microalgae cultivation for bioenergy production.

    Science.gov (United States)

    Chen, Yi-di; Ho, Shih-Hsin; Nagarajan, Dillirani; Ren, Nan-Qi; Chang, Jo-Shu

    2018-04-01

    Commercialization of microalgal cultivation has been well realized in recent decades with the use of effective strains that can yield the target products, but it is still challenged by the high costs arising from mass production, harvesting, and further processing. Recently, more interest has been directed towards the utilization of waste resources, such as sludge digestate, to enhance the economic feasibility and sustainability of microalgae production. Anaerobic digestion for waste disposal and phototrophic microalgal cultivation are well-characterized technologies in both fields. However, integration of anaerobic digestion and microalgal cultivation to achieve substantial economic and environmental benefits is extremely limited, and thus deserves more attention and research effort. In particular, combining these two makes possible an ideal 'waste biorefinery' model, as the C/N/P content in the anaerobic digestate can be used to produce microalgal biomass that serves as feedstock for biofuels, while biogas upgrading can simultaneously be performed by phototrophic CO 2 fixation during microalgal growth. This review is thus aimed at elucidating recent advances as well as challenges and future directions with regard to waste biorefineries associated with the integration of anaerobic waste treatment and microalgal cultivation for bioenergy production. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. The Green Integrated Forest Biorefinery: An innovative concept for the pulp and paper mills

    International Nuclear Information System (INIS)

    Rafione, Tatiana; Marinova, Mariya; Montastruc, Ludovic; Paris, Jean

    2014-01-01

    The Green Integrated Forest Biorefinery (GIFBR), a new concept suitable for implementation in pulp and paper mills is characterized by low greenhouse gases emissions, reduced water consumption and production of effluents. Its fossil fuel consumption must be nil. Several challenges have to be addressed to develop a sustainable GIFBR facility. An implementation strategy by phase is proposed to schedule the total capital investment over several years and to mitigate the economic risks associated with the transformation of an existing pulp and paper mill into a GIFBR. In the first phase of the methodology, the receptor mill and the biorefinery plant are selected. An intensive energy and material integration of the two plants is performed in the second phase, then a gasification unit is implemented and, finally a polygeneration unit is installed. The methodology is illustrated by application to a case study based on a reference Canadian Kraft mill. Each phase of the implementation strategy of the GIFBR is described. - Highlights: • The Green Integrated Forest Biorefinery (GIFBR) is a new biorefinery concept. • A GIFBR includes a pulp mill, a biorefinery, a gasification and a polygeneration units. • An implementation strategy by phase is proposed to successfully develop a GIFBR. • To determine achievable level of integration between the GIFBR constituents is crucial. • GIFBR concept technically and economically feasibility for pulp and paper mills

  3. Integration of Microbial Electrolysis Cells (MECs) in the Biorefinery for Production of Ethanol, H2 and Phenolics

    DEFF Research Database (Denmark)

    Thygesen, Anders; Thomsen, Anne Belinda; Possemiers, Sam

    2010-01-01

    production. The mass and energy balances as well as the economical evaluations, show that this strategy may be useful for additional generation of hydrogen and lignin, thereby increasing the final yield of this biorefinery. From one ton of straw, the yield of ethanol upon yeast fermentation is estimated......In a biorefinery, biomass is converted into a variety of chemicals, materials and energy. A typical example is the lignocellulosic ethanol biorefinery process, in which substrates such as wheat straw are used as a feedstock for production of ethanol. In this work, an integrated biorefinery...

  4. Development of efficient, integrated cellulosic biorefineries : LDRD final report.

    Energy Technology Data Exchange (ETDEWEB)

    Teh, Kwee-Yan; Hecht, Ethan S.; Shaddix, Christopher R.; Buffleben, George M.; Dibble, Dean C.; Lutz, Andrew E.

    2010-09-01

    Cellulosic ethanol, generated from lignocellulosic biomass sources such as grasses and trees, is a promising alternative to conventional starch- and sugar-based ethanol production in terms of potential production quantities, CO{sub 2} impact, and economic competitiveness. In addition, cellulosic ethanol can be generated (at least in principle) without competing with food production. However, approximately 1/3 of the lignocellulosic biomass material (including all of the lignin) cannot be converted to ethanol through biochemical means and must be extracted at some point in the biochemical process. In this project we gathered basic information on the prospects for utilizing this lignin residue material in thermochemical conversion processes to improve the overall energy efficiency or liquid fuel production capacity of cellulosic biorefineries. Two existing pretreatment approaches, soaking in aqueous ammonia (SAA) and the Arkenol (strong sulfuric acid) process, were implemented at Sandia and used to generated suitable quantities of residue material from corn stover and eucalyptus feedstocks for subsequent thermochemical research. A third, novel technique, using ionic liquids (IL) was investigated by Sandia researchers at the Joint Bioenergy Institute (JBEI), but was not successful in isolating sufficient lignin residue. Additional residue material for thermochemical research was supplied from the dilute-acid simultaneous saccharification/fermentation (SSF) pilot-scale process at the National Renewable Energy Laboratory (NREL). The high-temperature volatiles yields of the different residues were measured, as were the char combustion reactivities. The residue chars showed slightly lower reactivity than raw biomass char, except for the SSF residue, which had substantially lower reactivity. Exergy analysis was applied to the NREL standard process design model for thermochemical ethanol production and from a prototypical dedicated biochemical process, with process data

  5. Maximizing biofuel production in a thermochemical biorefinery by adding electrolytic hydrogen and by integrating torrefaction with entrained flow gasification

    DEFF Research Database (Denmark)

    Clausen, Lasse Røngaard

    2015-01-01

    double the biofuel production per biomass input by converting almost all of the carbon in the biomass feed to carbon stored in the biofuel product. Water or steam electrolysis can supply the hydrogen to the biorefinery and also the oxygen for the gasifier. This paper presents the design and thermodynamic...... analysis of two biorefineries integrating water electrolysis for the production of methanol. In both plants, torrefied woody biomass is supplied to an entrained flow gasifier, but in one of the plants, the torrefaction process occurs on-site, as it is integrated with the entrained flow gasification process....... The analysis shows that the biorefinery with integrated torrefaction has a higher biomass to methanol energy ratio (136% vs. 101%) as well as higher total energy efficiency (62% vs. 56%). By comparing with two identical biorefineries without electrolysis, it is concluded that the biorefinery with integrated...

  6. Integrated production of cellulosic bioethanol and succinic acid from industrial hemp in a biorefinery concept

    DEFF Research Database (Denmark)

    Kuglarz, Mariusz; Alvarado-Morales, Merlin; Karakashev, Dimitar Borisov

    2016-01-01

    The aim of this study was to develop integrated biofuel (cellulosic bioethanol) and biochemical (succinic acid) production from industrial hemp (Cannabis sativa L.) in a biorefinery concept. Two types of pretreatments were studied (dilute-acid and alkaline oxidative method). High cellulose recovery...... productivity. With respect to succinic acid production, the highest productivity was obtained after liquid fraction fermentation originated from steam treatment with 1.5% of acid. The mass balance calculations clearly showed that 149 kg of EtOH and 115 kg of succinic acid can be obtained per 1 ton of dry hemp....... Results obtained in this study clearly document the potential of industrial hemp for a biorefinery....

  7. Environmental and economic sustainability of integrated production in bio-refineries : The thistle case in Sardinia

    NARCIS (Netherlands)

    Yazan, Devrim; Mandras, Giovanni; Garau, Giorgio

    2016-01-01

    This paper aims at evaluating the environmental and economic sustainability of bio-refineries that produce multiple products through their supply chains (SCs). A physical enterprise input-output (EIO) model is used to quantify the material/energy/waste flows and integrated to the monetary EIO model

  8. Comparative techno-economic assessment and LCA of selected integrated sugarcane-based biorefineries.

    Science.gov (United States)

    Gnansounou, Edgard; Vaskan, Pavel; Pachón, Elia Ruiz

    2015-11-01

    This work addresses the economic and environmental performance of integrated biorefineries based on sugarcane juice and residues. Four multiproduct scenarios were considered; two from sugar mills and the others from ethanol distilleries. They are integrated biorefineries producing first (1G) and second (2G) generation ethanol, sugar, molasses (for animal feed) and electricity in the context of Brazil. The scenarios were analysed and compared using techno-economic value-based approach and LCA methodology. The results show that the best economic configuration is provided by a scenario with largest ethanol production while the best environmental performance is presented by a scenario with full integration sugar - 1G2G ethanol production. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. Principles of biorefineries.

    Science.gov (United States)

    Kamm, B; Kamm, M

    2004-04-01

    Sustainable economic growth requires safe, sustainable resources for industrial production. For the future re-arrangement of a substantial economy to biological raw materials, completely new approaches in research and development, production and economy are necessary. Biorefineries combine the necessary technologies between biological raw materials and industrial intermediates and final products. The principal goal in the development of biorefineries is defined by the following: (biomass) feedstock-mix + process-mix --> product-mix. Here, particularly the combination between biotechnological and chemical conversion of substances will play an important role. Currently the "whole-crop biorefinery", "green biorefinery" and "lignocellulose-feedstock biorefinery" systems are favored in research and development.

  10. Hydrothermal pretreatments of macroalgal biomass for biorefineries

    DEFF Research Database (Denmark)

    Ruiz, Héctor A.; Rodríguez-Jasso, Rosa M.; Aguedo, Mario

    2015-01-01

    in accordance with the integrated biorefineries. Furthermore, biorefinery concept requires processes that allow efficient utilization of all components of the biomass. The pretreatment step in a biorefinery is often based on hydrothermal principles of high temperatures in aqueous solution. Therefore...

  11. Novel heat–integrated and intensified biorefinery process for cellulosic ethanol production from lignocellulosic biomass

    International Nuclear Information System (INIS)

    Nhien, Le Cao; Long, Nguyen Van Duc; Lee, Moonyong

    2017-01-01

    Highlights: • A compact biorefinery design was proposed for cellulosic ethanol purification. • Actual fermentation broth from lignocellulosic biomass was considered. • Process integration and intensification achieves competitive biorefinery context. • The response surface method optimizes the complex column structure effectively. • The proposed process could save up to 47.6% of total annual cost. - Abstract: Biofuels have the most potential as an alternative to fossil fuels and overcoming global warming, which has become one of the most serious environmental issues over the past few decades. As the world confronts food shortages due to an increase in world population, the development of biofuels from inedible lignocellulosic feedstock may be more sustainable in the long term. Inspired by the NREL conventional process, this paper proposes a novel heat–integrated and intensified biorefinery design for cellulosic ethanol production from lignocellulosic biomass. For the preconcentration section, heat pump assisted distillation and double–effect heat integration were evaluated, while a combination of heat–integrated technique and intensified technique, extractive dividing wall column (EDWC), was applied to enhance the process energy and cost efficiency for the purification section. A biosolvent, glycerol, which can be produced from biodiesel production, was used as the extracting solvent in an EDWC to obtain a high degree of integration in a biorefinery context. All configuration alternatives were simulated rigorously using Aspen Plus were based on the energy requirements, total annual costs (TAC), and total carbon dioxide emissions (TCE). In addition, the structure of the EDWC was optimized using the reliable response surface method, which was carried out using Minitab statistical software. The simulation results showed that the proposed heat–integrated and intensified process can save up to 47.6% and 56.9% of the TAC and TCE for the purification

  12. Biomass pre-extraction, hydrolysis and conversion process improvements fro an integrated biorefinery

    Energy Technology Data Exchange (ETDEWEB)

    Jansen, Robert [Virdia, Inc., Danville, VA (United States)

    2014-12-23

    In this project, Virdia will show that it can improve the production of sugars suitable for the conversion into advanced biofuels from a range of woods. Several biomass feedstocks (Pine wood chips & Eucalyptus wood chips) will be tested on this new integrated biorefinery platform. The resultant drop-in biodiesel can be a cost-effective petroleum-replacement that can compete with projected market prices

  13. System visualization of integrated biofuels and high value chemicals developed within the MacroAlgaeBiorefinery (MAB3) project

    DEFF Research Database (Denmark)

    Seghetta, Michele; Hasler, Berit; Bastianoni, Simone

    MacroAlgaeBiorefinery (MAB3) may functions as production platform and raw material supplier for future sustainable production chains of biofuels and high value chemicals. Biofuels are interesting energy source but challenges in terms of the composition of the biomass and resulting energy...... efficiencies has to be compensated for to make the biofuel prices competitive in replacing fossil fuel. Since it is difficult to increase the yield of the single biorefinery, the overall system productivity can be improved integrating different sub-systems. In this study, macroalgae cultivation in Denmark...... is integrated with a biogas biorefinery, a bioethanol biorefinery and a fish feed industry. The modeled system is able to adapt itself to different amount and quality of feedstock and to maximize valuable outputs (e.g. bio-fuels and chemical). Macroalgae are harvested and utilized as feedstock in bioethanol...

  14. Design methodology for integrated downstream separation systems in an ethanol biorefinery

    Science.gov (United States)

    Mohammadzadeh Rohani, Navid

    and obtaining energy security. On the other hand, Process Integration (PI) as defined by Natural Resource Canada as the combination of activities which aim at improving process systems, their unit operations and their interactions in order to maximize the efficiency of using water, energy and raw materials can also help biorefineries lower their energy consumptions and improve their economics. Energy integration techniques such as pinch analysis adopted by different industries over the years have ensured using heat sources within a plant to supply the demand internally and decrease the external utility consumption. Therefore, adopting energy integration can be one of the ways biorefinery technology owners can consider in their process development as well as their business model in order to improve their overall economics. The objective of this thesis is to propose a methodology for designing integrated downstream separation in a biorefinery. This methodology is tested in an ethanol biorefinery case study. Several alternative separation techniques are evaluated in their energy consumption and economics in three different scenarios; stand-alone without energy integration, stand-alone with internal energy integration and integrated-with Kraft. The energy consumptions and capital costs of separation techniques are assessed in each scenario and the cost and benefit of integration are determined and finally the best alternative is found through techno-economic metrics. Another advantage of this methodology is the use of a graphical tool which provides insights on decreasing energy consumption by modifying the process condition. The pivot point of this work is the use of a novel energy integration method called Bridge analysis. This systematic method which originally is intended for retrofit situation is used here for integration with Kraft process. Integration potentials are identified through this method and savings are presented for each design. In stand-alone with

  15. Integrated torrefaction vs. external torrefaction – A thermodynamic analysis for the case of a thermochemical biorefinery

    International Nuclear Information System (INIS)

    Clausen, Lasse R.

    2014-01-01

    Integrated and external torrefaction is analyzed and compared via thermodynamic modeling. In this paper, integrated torrefaction is defined as torrefaction integrated with entrained flow gasification. External torrefaction is defined as the decentralized production of torrefied wood pellets and centralized conversion of the pellets by entrained flow gasification. First, the syngas production of the two methods was compared. Second, the two methods were compared by considering complete biorefineries with either integrated torrefaction or external torrefaction. The first part of the analysis showed that the biomass to syngas efficiency can be increased from 63% to 86% (LHV-dry) when switching from external torrefaction to integrated torrefaction. The second part of the analysis showed that the total energy efficiency (biomass to methanol + net electricity) could be increased from 53% to 63% when switching from external torrefaction to integrated torrefaction. The costs of this increase in energy efficiency are as follows: 1) more difficult transport, storage and handling of the biomass feedstock (wood chips vs. torrefied wood pellets); 2) reduced plant size; 3) no net electricity production; and 4) a more complex plant design. - Highlights: • Integrated torrefaction is compared with external torrefaction. • Biomass to syngas energy efficiencies of 63–86% are achieved. • Two thermochemical biorefinery are designed and analysed by thermodynamic modeling. • Biomass to fuel + electricity energy efficiencies of 53–63% are achieved. • The pros and cons of integrated torrefaction are described

  16. Pilot-Scale Biorefinery: Sustainable Transport Fuels from Biomass and Algal Residues via Integrated Pyrolysis, Catalytic Hydroconversion and Co-processing with Vacuum Gas Oil

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, Douglas [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Olarte, M. V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hart, T. R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-07-21

    Beginning in 2010, UOP, along with the Department of Energy and other project partners, designed a pathway for an integrated biorefinery to process solid biomass into transportation fuel blendstocks. The integrated biorefinery (IBR) would convert second generation feedstocks into pyrolysis oil which would then be upgraded into fuel blendstocks without the limitations of traditional biofuels.

  17. Life cycle assessment of biofuels from an integrated Brazilian algae-sugarcane biorefinery

    International Nuclear Information System (INIS)

    Souza, Simone P.; Gopal, Anand R.; Seabra, Joaquim E.A.

    2015-01-01

    Sugarcane ethanol biorefineries in Brazil produce carbon dioxide, electricity and heat as byproducts. These are essential inputs for algae biodiesel production. In this paper, we assessed ethanol's life cycle greenhouse gas emissions and fossil energy use produced in an integrated sugarcane and algae biorefinery where biodiesel replaces petroleum diesel for all agricultural operations. Carbon dioxide from cane juice fermentation is used as the carbon source for algae cultivation, and sugarcane bagasse is the sole source of energy for the entire facility. Glycerin produced from the biodiesel plant is consumed by algae during the mixotrophic growth phase. We assessed the uncertainties through a detailed Monte-Carlo analysis. We found that this integrated system can improve both the life cycle greenhouse gas emissions and the fossil energy use of sugarcane ethanol by around 10% and 50%, respectively, compared to a traditional Brazilian sugarcane ethanol distillery. - Highlights: • A high diesel consumption is associated to the ethanol sugarcane life-cycle. • Sugarcane industry can provide sources of carbon and energy for the algae growing. • The sugarcane-algae integration can improve the ethanol life-cycle performance. • This integration is a promising pathway for the deployment of algae biodiesel. • There are still significant techno-economic barriers associated with algae biodiesel

  18. How Does Alkali Aid Protein Extraction in Green Tea Leaf Residue: A Basis for Integrated Biorefinery of Leaves

    Science.gov (United States)

    Zhang, Chen; Sanders, Johan P. M.; Xiao, Ting T.; Bruins, Marieke E.

    2015-01-01

    Leaf protein can be obtained cost-efficiently by alkaline extraction, but overuse of chemicals and low quality of (denatured) protein limits its application. The research objective was to investigate how alkali aids protein extraction of green tea leaf residue, and use these results for further improvements in alkaline protein biorefinery. Protein extraction yield was studied for correlation to morphology of leaf tissue structure, protein solubility and hydrolysis degree, and yields of non-protein components obtained at various conditions. Alkaline protein extraction was not facilitated by increased solubility or hydrolysis of protein, but positively correlated to leaf tissue disruption. HG pectin, RGII pectin, and organic acids were extracted before protein extraction, which was followed by the extraction of cellulose and hemi-cellulose. RGI pectin and lignin were both linear to protein yield. The yields of these two components were 80% and 25% respectively when 95% protein was extracted, which indicated that RGI pectin is more likely to be the key limitation to leaf protein extraction. An integrated biorefinery was designed based on these results. PMID:26200774

  19. How Does Alkali Aid Protein Extraction in Green Tea Leaf Residue: A Basis for Integrated Biorefinery of Leaves.

    Directory of Open Access Journals (Sweden)

    Chen Zhang

    Full Text Available Leaf protein can be obtained cost-efficiently by alkaline extraction, but overuse of chemicals and low quality of (denatured protein limits its application. The research objective was to investigate how alkali aids protein extraction of green tea leaf residue, and use these results for further improvements in alkaline protein biorefinery. Protein extraction yield was studied for correlation to morphology of leaf tissue structure, protein solubility and hydrolysis degree, and yields of non-protein components obtained at various conditions. Alkaline protein extraction was not facilitated by increased solubility or hydrolysis of protein, but positively correlated to leaf tissue disruption. HG pectin, RGII pectin, and organic acids were extracted before protein extraction, which was followed by the extraction of cellulose and hemi-cellulose. RGI pectin and lignin were both linear to protein yield. The yields of these two components were 80% and 25% respectively when 95% protein was extracted, which indicated that RGI pectin is more likely to be the key limitation to leaf protein extraction. An integrated biorefinery was designed based on these results.

  20. Methodology for optimization of process integration schemes in a biorefinery under uncertainty

    International Nuclear Information System (INIS)

    Marta Abreu de las Villas (Cuba))" data-affiliation=" (Departamento de Ingeniería Química. Facultad de Química y Farmacia. Universidad Central Marta Abreu de las Villas (Cuba))" >González-Cortés, Meilyn; Marta Abreu de las Villas (Cuba))" data-affiliation=" (Departamento de Ingeniería Química. Facultad de Química y Farmacia. Universidad Central Marta Abreu de las Villas (Cuba))" >Martínez-Martínez, Yenisleidys; Marta Abreu de las Villas (Cuba))" data-affiliation=" (Departamento de Ingeniería Química. Facultad de Química y Farmacia. Universidad Central Marta Abreu de las Villas (Cuba))" >Albernas-Carvajal, Yailet; Marta Abreu de las Villas (Cuba))" data-affiliation=" (Departamento de Ingeniería Química. Facultad de Química y Farmacia. Universidad Central Marta Abreu de las Villas (Cuba))" >Pedraza-Garciga, Julio; Marta Abreu de las Villas (Cuba))" data-affiliation=" (Departamento de Ingeniería Química. Facultad de Química y Farmacia. Universidad Central Marta Abreu de las Villas (Cuba))" >Morales-Zamora, Marlen

    2017-01-01

    The uncertainty has a great impact in the investment decisions, operability of the plants and in the feasibility of integration opportunities in the chemical processes. This paper, presents the steps to consider the optimization of process investment in the processes integration under conditions of uncertainty. It is shown the potentialities of the biomass cane of sugar for the integration with several plants in a biorefinery scheme for the obtaining chemical products, thermal and electric energy. Among the factories with potentialities for this integration are the pulp and paper and sugar factories and other derivative processes. Theses factories have common resources and also have a variety of products that can be exchange between them so certain products generated in a one of them can be raw matter in another plant. The methodology developed guide to obtaining of feasible investment projects under uncertainty. As objective function was considered the maximization of net profitable value in different scenarios that are generated from the integration scheme. (author)

  1. Integrated torrefaction vs. external torrefaction - A thermodynamic analysis for the case of a thermochemical biorefinery

    DEFF Research Database (Denmark)

    Clausen, Lasse Røngaard

    2014-01-01

    Integrated and external torrefaction is analyzed and compared via thermodynamic modeling. In this paper, integrated torrefaction is defined as torrefaction integrated with entrained flow gasification. External torrefaction is defined as the decentralized production of torrefied wood pellets...... and centralized conversion of the pellets by entrained flow gasification. First, the syngas production of the two methods was compared. Second, the two methods were compared by considering complete biorefineries with either integrated torrefaction or external torrefaction. The first part of the analysis showed...... from external torrefaction to integrated torrefaction. The costs of this increase in energy efficiency are as follows: 1) more difficult transport, storage and handling of the biomass feedstock (wood chips vs. torrefied wood pellets); 2) reduced plant size; 3) no net electricity production; and 4...

  2. Integrated Biorefineries: Reducing Investment Risk in Novel Technologies

    Energy Technology Data Exchange (ETDEWEB)

    None

    2016-08-18

    Achieving national energy and climate goals will require a large, economically viable, and environmentally sustainable U.S. bioeconomy. The U.S. goal to build a diverse, robust, and resilient energy sector creates an urgent need to bridge the gap between promising research and pioneering large scale production of advanced biofuels.

  3. A model biorefinery for avocado (Persea americana mill.) processing.

    Science.gov (United States)

    Dávila, Javier A; Rosenberg, Moshe; Castro, Eulogio; Cardona, Carlos A

    2017-11-01

    This research investigated and evaluated a biorefinery for processing avocado Hass variety into microencapsulated phenolic compounds extract, ethanol, oil and xylitol. Avocado was first characterized for its potential valuable compounds; then, the techno-economic and environmental aspects of the biorefinery were developed and finally the total production costs and potential environmental impact of the proposed biorefinery were investigated. Four scenarios of the biorefinery were evaluated with different extent of mass and energy integration as well as the incorporation of a cogeneration system. Results indicated that the main fatty acid in the pulp of the investigated avocado variety was oleic acid (50.96%) and that this fruit contained significant amount of holocellulose (52.88% and 54.36% in the peel and seed, respectively). Techno-economic and environmental assessment suggested an attractive opportunity for a biorefinery for complete utilization of the avocado fruit as well the importance of the level of integration. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Integrated production of cellulosic bioethanol and succinic acid from industrial hemp in a biorefinery concept.

    Science.gov (United States)

    Kuglarz, Mariusz; Alvarado-Morales, Merlin; Karakashev, Dimitar; Angelidaki, Irini

    2016-01-01

    The aim of this study was to develop integrated biofuel (cellulosic bioethanol) and biochemical (succinic acid) production from industrial hemp (Cannabis sativa L.) in a biorefinery concept. Two types of pretreatments were studied (dilute-acid and alkaline oxidative method). High cellulose recovery (>95%) as well as significant hemicelluloses solubilization (49-59%) after acid-based method and lignin solubilization (35-41%) after alkaline H2O2 method were registered. Alkaline pretreatment showed to be superior over the acid-based method with respect to the rate of enzymatic hydrolysis and ethanol productivity. With respect to succinic acid production, the highest productivity was obtained after liquid fraction fermentation originated from steam treatment with 1.5% of acid. The mass balance calculations clearly showed that 149kg of EtOH and 115kg of succinic acid can be obtained per 1ton of dry hemp. Results obtained in this study clearly document the potential of industrial hemp for a biorefinery. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Conceptual design of sustainable integrated microalgae biorefineries: Parametric analysis of energy use, greenhouse gas emissions and techno-economics

    NARCIS (Netherlands)

    Posada, John; Brentner, Laura; Ramirez, Andrea; Patel, Martin

    2016-01-01

    This study covers four main aspects of the conceptual design of sustainable integrated microalgae-based biorefineries using flue gas from CO2-intensive industries (i.e. 100% CO2): i) screening of technologies (4 options for cultivation, 3 for culture dewatering, 3 for cell disruption, 4 for lipids

  6. Conceptual design of sustainable integrated microalgae biorefineries : Parametric analysis of energy use, greenhouse gas emissions and techno-economics

    NARCIS (Netherlands)

    Posada Duque, J.A.; Brentner, L.B.; Ramirez, A; Patel, MK

    2016-01-01

    This study covers four main aspects of the conceptual design of sustainable integrated microalgae-based biorefineries using flue gas from CO2-intensive industries (i.e. 100% CO2): i) screening of technologies (4 options for cultivation, 3 for culture dewatering, 3 for cell disruption, 4 for lipids

  7. Conceptual design of sustainable integrated microalgae biorefineries: Parametric analysis of energy use, greenhouse gas emissions and techno-economics

    NARCIS (Netherlands)

    Posada, John A.; Brentner, Laura B.; Ramirez, Andrea; Patel, Martin K.

    This study covers four main aspects of the conceptual design of sustainable integrated microalgae-based biorefineries using flue gas from CO2-intensive industries (i.e. 100% CO2): i) screening of technologies (4 options for cultivation, 3 for culture dewatering, 3 for cell disruption, 4 for lipids

  8. Solazyme Integrated Biorefinery (SzIBR): Diesel Fuels from Heterotrophic Algae

    Energy Technology Data Exchange (ETDEWEB)

    Brinkmann, David [Solazyme, Inc., South San Francisco, CA (United States)

    2014-12-23

    Under Department of Energy Award Number DE-EE0002877 (the “DOE Award”), Solazyme, Inc. (“Solazyme”) has built a demonstration scale “Solazyme Integrated Biorefinery (SzlBR).” The SzIBR was built to provide integrated scale-up of Solazyme’s novel heterotrophic algal oil biomanufacturing process, validate the projected commercial-scale economics of producing multiple algal oils, and to enable Solazyme to collect the data necessary to complete the design of its first commercial-scale facility. Solazyme’s technology enables it to convert a range of low-cost plant-based sugars into high-value oils. Solazyme’s renewable products replace or enhance oils derived from the world’s three existing sources—petroleum, plants, and animal fats. Solazyme tailors the composition of its oils to address specific customer requirements, offering superior performance characteristics and value. This report summarizes history and the results of the project.

  9. Towards integrated biorefinery from dried distillers grains: Selective extraction of pentoses using dilute acid hydrolysis

    International Nuclear Information System (INIS)

    Fonseca, Dania A.; Lupitskyy, Robert; Timmons, David; Gupta, Mayank; Satyavolu, Jagannadh

    2014-01-01

    The abundant availability and high level of hemicellulose content make dried distillers grains (DDG) an attractive feedstock for production of pentoses (C5) and conversion of C5 to bioproducts. One target of this work was to produce a C5 extract (hydrolyzate) with high yield and purity with a low concentration of C5 degradation products. A high selectivity towards pentoses was achieved using dilute acid hydrolysis of DDG in a percolation reactor with liquid recirculation. Pretreatment of starting material using screening and ultrasonication resulted in fractional increase of the pentose yield by 42%. A 94% yield of pentoses on the DDG (280.9 g kg −1 ) was obtained. Selective extraction of individual pentoses has been achieved by using a 2-stage hydrolysis process, resulting in arabinose-rich (arabinose 81.5%) and xylose-rich (xylose 85.2%) streams. A broader impact of this work is towards an Integrated Bio-Refinery based on DDG – for production of biofuels, biochemical intermediates, and other bioproducts. - Highlights: • A process for selective extraction of pentoses from DDG was presented as a part of integrated biorefinery approach. • The selectivity for pentoses was high using dilute acid hydrolysis in a percolation reactor with liquid recirculation. • Pretreatment of DDG using screening and ultrasonication resulted in fractional increase of the pentose yield by 42 %. • A 94% yield in pentoses (280.9 g kg −1 of DDG) was obtained. • A 2-stage hydrolysis process, developed to extract individual pentoses, resulted in arabinose and xylose rich streams

  10. Economic Analysis of an Integrated Annatto Seeds-Sugarcane Biorefinery Using Supercritical CO2 Extraction as a First Step

    Directory of Open Access Journals (Sweden)

    Juliana Q. Albarelli

    2016-06-01

    Full Text Available Recently, supercritical fluid extraction (SFE has been indicated to be utilized as part of a biorefinery, rather than as a stand-alone technology, since besides extracting added value compounds selectively it has been shown to have a positive effect on the downstream processing of biomass. To this extent, this work evaluates economically the encouraging experimental results regarding the use of SFE during annatto seeds valorization. Additionally, other features were discussed such as the benefits of enhancing the bioactive compounds concentration through physical processes and of integrating the proposed annatto seeds biorefinery to a hypothetical sugarcane biorefinery, which produces its essential inputs, e.g., CO2, ethanol, heat and electricity. For this, first, different configurations were modeled and simulated using the commercial simulator Aspen Plus® to determine the mass and energy balances. Next, each configuration was economically assessed using MATLAB. SFE proved to be decisive to the economic feasibility of the proposed annatto seeds-sugarcane biorefinery concept. SFE pretreatment associated with sequential fine particles separation process enabled higher bixin-rich extract production using low-pressure solvent extraction method employing ethanol, meanwhile tocotrienols-rich extract is obtained as a first product. Nevertheless, the economic evaluation showed that increasing tocotrienols-rich extract production has a more pronounced positive impact on the economic viability of the concept.

  11. Sustainability of algal biofuel production using integrated renewable energy park (IREP) and algal biorefinery approach

    International Nuclear Information System (INIS)

    Subhadra, Bobban G.

    2010-01-01

    Algal biomass can provide viable third generation feedstock for liquid transportation fuel. However, for a mature commercial industry to develop, sustainability as well as technological and economic issues pertinent to algal biofuel sector must be addressed first. This viewpoint focuses on three integrated approaches laid out to meet these challenges. Firstly, an integrated algal biorefinery for sequential biomass processing for multiple high-value products is delineated to bring in the financial sustainability to the algal biofuel production units. Secondly, an integrated renewable energy park (IREP) approach is proposed for amalgamating various renewable energy industries established in different locations. This would aid in synergistic and efficient electricity and liquid biofuel production with zero net carbon emissions while obviating numerous sustainability issues such as productive usage of agricultural land, water, and fossil fuel usage. A 'renewable energy corridor' rich in multiple energy sources needed for algal biofuel production for deploying IREPs in the United States is also illustrated. Finally, the integration of various industries with algal biofuel sector can bring a multitude of sustainable deliverables to society, such as renewable supply of cheap protein supplements, health products and aquafeed ingredients. The benefits, challenges, and policy needs of the IREP approach are also discussed.

  12. Field to fuel: developing sustainable biorefineries.

    Science.gov (United States)

    Jenkins, Robin; Alles, Carina

    2011-06-01

    Life-cycle assessment (LCA) can be used as a scientific decision support technique to quantify the environmental implications of various biorefinery process, feedstock, and integration options. The goal of DuPont's integrated corn biorefinery (ICBR) project, a cost-share project with the United States Department of Energy, was to demonstrate the feasibility of a cellulosic ethanol biorefinery concept. DuPont used LCA to guide research and development to the most sustainable cellulosic ethanol biorefinery design in its ICBR project and will continue to apply LCA in support of its ongoing effort with joint venture partners. Cellulosic ethanol is a biofuel which has the potential to provide a sustainable solution to the nation's growing concerns around energy supply and climate change. A successful biorefinery begins with sustainable removal of biomass from the field. Michigan State University (MSU) used LCA to estimate the environmental performance of corn grain, corn stover, and the corn cob portion of the stover, grown under various farming practices for several corn growing locations in the United States Corn Belt. In order to benchmark the future technology options for producing cellulosic ethanol with existing technologies, LCA results for fossil energy consumption and greenhouse gas (GHG) emissions are compared to alternative ethanol processes and conventional gasoline. Preliminary results show that the DuPont ICBR outperforms gasoline and other ethanol technologies in the life-cycle impact categories considered here.

  13. Biorefinery: from biomass to chemicals and fuels

    National Research Council Canada - National Science Library

    Aresta, M; Dibenedetto, Angela; Dumeignil, Franck

    2012-01-01

    ... to end-user requirements) of advanced biorefineries. This concept attempts to integrate the different scientific and industrial communities with the expectation to achieve a breakthrough beyond the "business as usual" scenario. DG Research has been frequently requested to work in closer coordination between its different Themes in order to better answer ...

  14. Fully Integrated Lignocellulosic Biorefinery with Onsite Production of Enzymes and Yeast

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Manoj [DSM Innovation, Incorporated, San Francisco, CA (United States)

    2010-06-14

    Lignocellulosic biomass is the most abundant, least expensive renewable natural biological resource for the production of biobased products and bioenergy is important for the sustainable development of human civilization in 21st century. For making the fermentable sugars from lignocellulosic biomass, a reduction in cellulase production cost, an improvement in cellulase performance, and an increase in sugar yields are all vital to reduce the processing costs of biorefineries. Improvements in specific cellulase activities for non-complexed cellulase mixtures can be implemented through cellulase engineering based on rational design or directed evolution for each cellulase component enzyme, as well as on the reconstitution of cellulase components. In this paper, we will provide DSM's efforts in cellulase research and developments and focus on limitations. Cellulase improvement strategies based on directed evolution using screening on relevant substrates, screening for higher thermal tolerance based on activity screening approaches such as continuous culture using insoluble cellulosic substrates as a powerful selection tool for enriching beneficial cellulase mutants from the large library. We will illustrate why and how thermostable cellulases are vital for economic delivery of bioproducts from cellulosic biomass using biochemical conversion approach.

  15. Integrated cellulosic enzymes hydrolysis and fermentative advanced yeast bioconversion solution ready for biomass biorefineries

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Manoj [DSM Innovation, Inc., San Francisco, CA (United States)

    2011-05-04

    These are slides from this conference. Lignocellulosic biomass is the most abundant, least expensive renewable natural biological resource for the production of biobased products and bioenergy is important for the sustainable development of human civilization in 21st century. For making the fermentable sugars from lignocellulosic biomass, a reduction in cellulase production cost, an improvement in cellulase performance, and an increase in sugar yields are all vital to reduce the processing costs of biorefineries. Improvements in specific cellulase activities for non-complexed cellulase mixtures can be implemented through cellulase engineering based on rational design or directed evolution for each cellulase component enzyme, as well as on the reconstitution of cellulase components. In this paper, we will provide DSM's efforts in cellulase research and developments and focus on limitations. Cellulase improvement strategies based on directed evolution using screening on relevant substrates, screening for higher thermal tolerance based on activity screening approaches such as continuous culture using insoluble cellulosic substrates as a powerful selection tool for enriching beneficial cellulase mutants from the large library. We will illustrate why and how thermostable cellulases are vital for economic delivery of bioproducts from cellulosic biomass using biochemical conversion approach.

  16. Vertical Integration of Biomass Saccharification of Enzymes for Sustainable Cellulosic Biofuel Production in a Biorefinery

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Manoj [DSM Innovation, Inc., San Francisco, CA (United States)

    2011-05-09

    These are a set of slides from this conference. Lignocellulosic biomass is the most abundant, least expensive renewable natural biological resource for the production of biobased products and bioenergy is important for the sustainable development of human civilization in 21st century. For making the fermentable sugars from lignocellulosic biomass, a reduction in cellulase production cost, an improvement in cellulase performance, and an increase in sugar yields are all vital to reduce the processing costs of biorefineries. Improvements in specific cellulase activities for non-complexed cellulase mixtures can be implemented through cellulase engineering based on rational design or directed evolution for each cellulase component enzyme, as well as on the reconstitution of cellulase components. In this paper, we will provide DSM's efforts in cellulase research and developments and focus on limitations. Cellulase improvement strategies based on directed evolution using screening on relevant substrates, screening for higher thermal tolerance based on activity screening approaches such as continuous culture using insoluble cellulosic substrates as a powerful selection tool for enriching beneficial cellulase mutants from the large library. We will illustrate why and how thermostable cellulases are vital for economic delivery of bioproducts from cellulosic biomass using biochemical conversion approach.

  17. The pros and cons of lignin valorisation in an integrated biorefinery

    NARCIS (Netherlands)

    Strassberger, Z.; Tanase, S.; Rothenberg, G.

    2014-01-01

    This short critical review outlines possible scenarios for using lignin as a feedstock in a biorefinery environment. We first explain the position of biomass with respect to fossil carbon sources and the possibilities of substituting these in tomorrow's transportation fuels, energy, and chemicals

  18. Recovery Act. Demonstration of a Pilot Integrated Biorefinery for the Efficient, Direct Conversion of Biomass to Diesel Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Schuetzle, Dennis [Renewable Energy Institute International, Sacramentao, CA (United States); Tamblyn, Greg [Renewable Energy Institute International, Sacramentao, CA (United States); Caldwell, Matt [Renewable Energy Institute International, Sacramentao, CA (United States); Hanbury, Orion [Renewable Energy Institute International, Sacramentao, CA (United States); Schuetzle, Robert [Greyrock Energy, Sacramento, CA (United States); Rodriguez, Ramer [Greyrock Energy, Sacramento, CA (United States); Johnson, Alex [Red Lion Bio-Energy, Toledo, OH (United States); Deichert, Fred [Red Lion Bio-Energy, Toledo, OH (United States); Jorgensen, Roger [Red Lion Bio-Energy, Toledo, OH (United States); Struble, Doug [Red Lion Bio-Energy, Toledo, OH (United States)

    2015-05-12

    The Renewable Energy Institute International, in collaboration with Greyrock Energy and Red Lion Bio-Energy (RLB) has successfully demonstrated operation of a 25 ton per day (tpd) nameplate capacity, pilot, pre-commercial-scale integrated biorefinery (IBR) plant for the direct production of premium, “drop-in”, synthetic fuels from agriculture and forest waste feedstocks using next-generation thermochemical and catalytic conversion technologies. The IBR plant was built and tested at the Energy Center, which is located in the University of Toledo Medical Campus in Toledo, Ohio.

  19. Case study: Preliminary assessment of integrated palm biomass biorefinery for bioethanol production utilizing non-food sugars from oil palm frond petiole

    International Nuclear Information System (INIS)

    Abdullah, Sharifah Soplah Syed; Shirai, Yoshihito; Ali, Ahmad Amiruddin Mohd; Mustapha, Mahfuzah; Hassan, Mohd Ali

    2016-01-01

    Highlights: • Fermentable sugars production from oil palm frond by integrated technology concept. • Bioethanol production from oil palm frond sugars in a biorefinery. • Palm oil mills have sufficient excess energy and steam to support biorefinery. • The net energy ratio of bioethanol from oil palm frond petiole is 7.48. - Abstract: In this case study, a preliminary assessment on the bioethanol production from oil palm frond (OPF) petiole sugars within an integrated palm biomass biorefinery was carried out. Based on the case study of 4 neighbouring palm oil mills, approximately 55,600 t/y of fermentable sugars could be obtained from OPF petiole. The integrated biorefinery will be located at one of the 4 mills. The mill has potential excess energy comprising 3.64 GW h/y of electricity and 177,000 t/y of steam which are sufficient to run the biorefinery. With 33.9 million litres/y of bioethanol production, the specific production cost of bioethanol is estimated at $ 0.52/l bioethanol, compared to $ 0.31–0.34/l bioethanol produced from sugarcane and $ 0.49–0.60/l bioethanol from other lignocellulosics. The net energy ratio of 7.48 for bioethanol production from OPF provides a promising alternative for OPF utilization as a non-food sugar feedstock.

  20. Sugarcane-Biorefinery.

    Science.gov (United States)

    Vaz, Sílvio

    2017-03-17

    Concepts such as biorefinery and green chemistry focus on the usage of biomass, as with the oil value chain. However, it can cause less negative impact on the environment. A biorefinery based on sugarcane (Saccharum spp.) as feedstock is an example, because it can integrate into the same physical space, of processes for obtaining biofuels (ethanol), chemicals (from sugars or ethanol), electricity, and heat.The use of sugarcane as feedstock for biorefineries is dictated by its potential to supply sugars, ethanol, natural polymers or macromolecules, organic matter, and other compounds and materials. By means of conversion processes (chemical, biochemical, and thermochemical), sugarcane biomass can be transformed into high-value bioproducts to replace petrochemicals, as a bioeconomy model.

  1. Pilot-Scale Biorefinery: Sustainable Transport Fuels from Biomass via Integrated Pyrolysis and Catalytic Hydroconversion - Wastewater Cleanup by Catalytic Hydrothermal Gasification

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, Douglas C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Olarte, Mariefel V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hart, Todd R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-06-19

    DOE-EE Bioenergy Technologies Office has set forth several goals to increase the use of bioenergy and bioproducts derived from renewable resources. One of these goals is to facilitate the implementation of the biorefinery. The biorefinery will include the production of liquid fuels, power and, in some cases, products. The integrated biorefinery should stand-alone from an economic perspective with fuels and power driving the economy of scale while the economics/profitability of the facility will be dependent on existing market conditions. UOP LLC proposed to demonstrate a fast pyrolysis based integrated biorefinery. Pacific Northwest National Laboratory (PNNL) has expertise in an important technology area of interest to UOP for use in their pyrolysis-based biorefinery. This CRADA project provides the supporting technology development and demonstration to allow incorporation of this technology into the biorefinery. PNNL developed catalytic hydrothermal gasification (CHG) for use with aqueous streams within the pyrolysis biorefinery. These aqueous streams included the aqueous phase separated from the fast pyrolysis bio-oil and the aqueous byproduct streams formed in the hydroprocessing of the bio-oil to finished products. The purpose of this project was to demonstrate a technically and economically viable technology for converting renewable biomass feedstocks to sustainable and fungible transportation fuels. To demonstrate the technology, UOP constructed and operated a pilot-scale biorefinery that processed one dry ton per day of biomass using fast pyrolysis. Specific objectives of the project were to: The anticipated outcomes of the project were a validated process technology, a range of validated feedstocks, product property and Life Cycle data, and technical and operating data upon which to base the design of a full-scale biorefinery. The anticipated long-term outcomes from successful commercialization of the technology were: (1) the replacement of a significant

  2. Environmental impacts of producing bioethanol and biobased lactic acid from standalone and integrated biorefineries using a consequential and an attributional life cycle assessment approach

    DEFF Research Database (Denmark)

    Parajuli, Ranjan; Knudsen, Marie Trydeman; Birkved, Morten

    2017-01-01

    : a standalone system producing bioethanol from winter wheat-straw (system A), a standalone system producing biobased lactic acid from alfalfa (system B), and an integrated biorefinery system (system C) combining the two standalone systems and producing both bioethanol and lactic acid. The synergy...

  3. Environmental impacts of producing bioethanol and biobased lactic acid from standalone and integrated biorefineries using a consequential and an attributional life cycle assessment approach.

    Science.gov (United States)

    Parajuli, Ranjan; Knudsen, Marie Trydeman; Birkved, Morten; Djomo, Sylvestre Njakou; Corona, Andrea; Dalgaard, Tommy

    2017-11-15

    This study evaluates the environmental impacts of biorefinery products using consequential (CLCA) and attributional (ALCA) life cycle assessment (LCA) approaches. Within ALCA, economic allocation method was used to distribute impacts among the main products and the coproducts, whereas within the CLCA system expansion was adopted to avoid allocation. The study seeks to answer the questions (i) what is the environmental impacts of process integration?, and (ii) do CLCA and ALCA lead to different conclusions when applied to biorefinery?. Three biorefinery systems were evaluated and compared: a standalone system producing bioethanol from winter wheat-straw (system A), a standalone system producing biobased lactic acid from alfalfa (system B), and an integrated biorefinery system (system C) combining the two standalone systems and producing both bioethanol and lactic acid. The synergy of the integration was the exchange of useful energy necessary for biomass processing in the two standalone systems. The systems were compared against a common reference flow: "1MJ EtOH +1kg LA ", which was set on the basis of products delivered by the system C. Function of the reference flow was to provide service of both fuel (bioethanol) at 99.9% concentration (wt. basis) and biochemical (biobased lactic acid) in food industries at 90% purity; both products delivered at biorefinery gate. The environmental impacts of interest were global warming potential (GWP 100 ), eutrophication potential (EP), non-renewable energy (NRE) use and the agricultural land occupation (ALO). Regardless of the LCA approach adopted, system C performed better in most of the impact categories than both standalone systems. The process wise contribution to the obtained environmental impacts also showed similar impact pattern in both approaches. The study also highlighted that the recirculation of intermediate materials, e.g. C 5 sugar to boost bioethanol yield and that the use of residual streams in the energy

  4. Integration of Biorefineries and Nuclear Cogeneration Power Plants - A Preliminary Analysis

    International Nuclear Information System (INIS)

    Greene, Sherrell R.; Flanagan, George F.; Borole, Abhijeet P.

    2009-01-01

    Biomass-based ethanol and nuclear power are two viable elements in the path to U.S. energy independence. Numerous studies suggest nuclear power could provide a practical carbon-free heat source alternative for the production of biomass-based ethanol. In order for this coupling to occur, it is necessary to examine the interfacial requirements of both nuclear power plants and bioethanol refineries. This report describes the proposed characteristics of a small cogeneration nuclear power plant, a biochemical process-based cellulosic bioethanol refinery, and a thermochemical process-based cellulosic biorefinery. Systemic and interfacial issues relating to the co-location of either type of bioethanol facility with a nuclear power plant are presented and discussed. Results indicate future co-location efforts will require a new optimized energy strategy focused on overcoming the interfacial challenges identified in the report.

  5. Integration of Biorefineries and Nuclear Cogeneration Power Plants - A Preliminary Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Greene, Sherrell R [ORNL; Flanagan, George F [ORNL; Borole, Abhijeet P [ORNL

    2009-03-01

    Biomass-based ethanol and nuclear power are two viable elements in the path to U.S. energy independence. Numerous studies suggest nuclear power could provide a practical carbon-free heat source alternative for the production of biomass-based ethanol. In order for this coupling to occur, it is necessary to examine the interfacial requirements of both nuclear power plants and bioethanol refineries. This report describes the proposed characteristics of a small cogeneration nuclear power plant, a biochemical process-based cellulosic bioethanol refinery, and a thermochemical process-based cellulosic biorefinery. Systemic and interfacial issues relating to the co-location of either type of bioethanol facility with a nuclear power plant are presented and discussed. Results indicate future co-location efforts will require a new optimized energy strategy focused on overcoming the interfacial challenges identified in the report.

  6. Supply Chain Optimization of Integrated Glycerol Biorefinery: GlyThink Model Development and Application

    DEFF Research Database (Denmark)

    Loureiro da Costa Lira Gargalo, Carina; Carvalho, Ana; Gernaey, Krist

    2017-01-01

    To further advance the development and implementation of glycerol-based biorefinery concepts, it is critical to analyze the glycerol conversion into high value-added products in a holistic manner, considering both production as well as the logistics aspects related to the supply chain structure...... is able to identify operational decisions, including locations, capacity levels, technologies, and product portfolio, as well as strategic decisions such as inventory levels, production amounts, and transportation to the final markets. Several technologies are considered for the glycerol valorization...... to high value-added products. Existing countries with major production and consumption of biodiesel in Europe are considered as candidates for the facility sites and demand markets, and their spatial distribution is also carefully studied. The results showed that (i) the optimal solution that provides...

  7. An integrated biorefinery concept for conversion of sugar beet pulp into value-added chemicals and pharmaceutical intermediates.

    Science.gov (United States)

    Cárdenas-Fernández, Max; Bawn, Maria; Hamley-Bennett, Charlotte; Bharat, Penumathsa K V; Subrizi, Fabiana; Suhaili, Nurashikin; Ward, David P; Bourdin, Sarah; Dalby, Paul A; Hailes, Helen C; Hewitson, Peter; Ignatova, Svetlana; Kontoravdi, Cleo; Leak, David J; Shah, Nilay; Sheppard, Tom D; Ward, John M; Lye, Gary J

    2017-09-21

    Over 8 million tonnes of sugar beet are grown annually in the UK. Sugar beet pulp (SBP) is the main by-product of sugar beet processing which is currently dried and sold as a low value animal feed. SBP is a rich source of carbohydrates, mainly in the form of cellulose and pectin, including d-glucose (Glu), l-arabinose (Ara) and d-galacturonic acid (GalAc). This work describes the technical feasibility of an integrated biorefinery concept for the fractionation of SBP and conversion of these monosaccharides into value-added products. SBP fractionation is initially carried out by steam explosion under mild conditions to yield soluble pectin and insoluble cellulose fractions. The cellulose is readily hydrolysed by cellulases to release Glu that can then be fermented by a commercial yeast strain to produce bioethanol at a high yield. The pectin fraction can be either fully hydrolysed, using physico-chemical methods, or selectively hydrolysed, using cloned arabinases and galacturonases, to yield Ara-rich and GalAc-rich streams. These monomers can be separated using either Centrifugal Partition Chromatography (CPC) or ultrafiltration into streams suitable for subsequent enzymatic upgrading. Building on our previous experience with transketolase (TK) and transaminase (TAm) enzymes, the conversion of Ara and GalAc into higher value products was explored. In particular the conversion of Ara into l-gluco-heptulose (GluHep), that has potential therapeutic applications in hypoglycaemia and cancer, using a mutant TK is described. Preliminary studies with TAm also suggest GluHep can be selectively aminated to the corresponding chiral aminopolyol. The current work is addressing the upgrading of the remaining SBP monomer, GalAc, and the modelling of the biorefinery concept to enable economic and Life Cycle Analysis (LCA).

  8. Biorefinery opportunities for the forest products industries

    Science.gov (United States)

    Alan W. Rudie

    2013-01-01

    Wood residues offer biorefinery opportunities for new products in our industries including fuel and chemicals. But industry must have two capabilities to succeed with biorefineries. Most forest products companies already have the first capability: knowing where the resource is, how to get it, and how much it will cost. They will need to integrate the acquisition of...

  9. Opportunities for Dutch Roadmap Biorefineries

    International Nuclear Information System (INIS)

    Annevelink, E.; Broeze, J.; Van Ree, R.

    2009-09-01

    This Dutch Roadmap Biorefinery forms the framework and knowledge basis for Research, Development and Demonstration (RD and D) activities, covering both technical and non-technical issues, necessary to develop biorefinery-based value chains to such an extend that large-scale market implementation as part of the future Bio-based Economy will become a reality. The Roadmap describes the broad landscape of biorefinery options in The Netherlands. The descriptions of possible initiatives within the so called Moonshots (general biorefinery strategies containing more specific biorefinery-based value chains that will become fully operational at industrial scale in the short and midterm to facilitate the transition to a Bio-based Economy in the longer-term) deliberately do not contain the names of parties that might be involved. However, many of the current initiatives have been described in another document, the 'Status Report Biorefinery 2007'. Also the exact economics of possible initiatives have not been specified yet. These will become clearer when proposals will be submitted by consortia of the stakeholders involved.

  10. Conceptual Biorefinery Design and Research Targeted for 2022: Hydrothermal Liquefacation Processing of Wet Waste to Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Snowden-Swan, Lesley J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zhu, Yunhua [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bearden, Mark D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Seiple, Timothy E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Jones, Susanne B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Schmidt, Andrew J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Billing, Justin M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hallen, Richard T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hart, Todd R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Liu, Jian [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Albrecht, Karl O. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fox, Samuel P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Maupin, Gary D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Elliott, Douglas C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2017-12-28

    represents a goal case for the pathway, targeting performance that is anticipated to be achievable by 2022 with further research and development. The year 2022 is BETO’s target year for verification of hydrocarbon biofuel pathways. As this analysis represents a goal case, assumed values of several design parameters represent improvements in the technology relative to what has currently been demonstrated in the laboratory. While HTL is fairly well developed and may therefore be ready for commercialization prior to 2022, there are specific advancements addressed in this analysis that are necessary to enhance performance compared to what has been demonstrated to date. In addition, an important aspect to the pathway is the upgrading of biocrude to fuel blendstock, an area that has received much less attention and requires significant research to validate the goal case performance parameters. The estimated plant gate minimum fuel selling price for fuel blendstock from sludge HTL and upgrading is $3.46/gasoline gallon equivalent (gge). This price is within the tolerance (+$0.49/gge) of BETO’s $3/gge programmatic cost target and illustrates that fuel blendstocks generated from HTL of sludge and centralized biocrude upgrading have the potential to be competitive with fossil fuels. This analysis illustrates the feasibility of HTL for point-of-generation conversion of waste feedstock at a scale 1/20th that of the standard lignocellulosic biorefinery scale typically used in BETO design cases. The relevance of this work reaches beyond wastewater treatment sludge to lay the groundwork for application to other distributed wet wastes and blends that together represent a significant resource of underutilized biomass.

  11. Recovery Act – Integrated Pilot-Scale Biorefinery for Producing Ethanol from Hybrid Algae

    Energy Technology Data Exchange (ETDEWEB)

    Legere, Ed [Algenol Biotech LLC, Ft. Myers, FL (United States); Roessler, Paul [Algenol Biotech LLC, Ft. Myers, FL (United States); Miller, Harlan [Algenol Biotech LLC, Ft. Myers, FL (United States); Belicka, Laura [Algenol Biotech LLC, Ft. Myers, FL (United States); Yuan, Yanhui [Algenol Biotech LLC, Ft. Myers, FL (United States); Chance, Ron [Algenol Biotech LLC, Ft. Myers, FL (United States); Dalrymple, Kofi [Algenol Biotech LLC, Ft. Myers, FL (United States); Porubsky, William [Algenol Biotech LLC, Ft. Myers, FL (United States); Coleman, John [Algenol Biotech LLC, Ft. Myers, FL (United States); Sweeney, Kevin [Algenol Biotech LLC, Ft. Myers, FL (United States); Ahlm, Pat [Algenol Biotech LLC, Ft. Myers, FL (United States); Ha, Quang [Algenol Biotech LLC, Ft. Myers, FL (United States)

    2017-05-26

    As a scientific and engineering endeavor, the Algenol IBR Biorefinery project has been a success by almost any measure. The vision for the system evolved significantly over the course of the project, always due to recognized opportunities for improved performance, lower energy consumption, and reduced costs. Our commitment to thorough, realistic, techno-economic and life cycle assessments has been an essential element for system innovation, technology guidance, and change management of the overall facility. The biological tools developed during this program for cyanobacteria are second to none, and are the primary reason for the remarkable improvements in organism performance. The breakthrough was the successful transformation of our most robust wild type organism (AB1) early in 2012. That was followed by a series of improvements over the next several years that produced strains wherein over 80% of the fixed carbon was converted into ethanol. At the same time, our expertise in cultivation, physiology, process engineering, CO2 management, and photobioreactor design and manufacturing grew at a comparable pace. We learned enormous amounts from the various upsets, weather variations, contamination events, and new technology related disappointments. We overcame those challenges to produce fuel grade ethanol with a low carbon footprint, and are within striking distance of economic viability even with the challenges of low fossil fuel prices.

  12. Biorefinery Analysis

    Energy Technology Data Exchange (ETDEWEB)

    2016-06-01

    Fact sheet summarizing NREL's techno-economic analysis and life-cycle assessment capabilities to connect research with future commercial process integration, a critical step in the scale-up of biomass conversion technologies.

  13. Anaerobic digestion in combination with 2nd generation ethanol production for maximizing biofuels yield from lignocellulosic biomass – testing in an integrated pilot-scale biorefinery plant

    DEFF Research Database (Denmark)

    Uellendahl, Hinrich; Ahring, Birgitte Kiær

    An integrated biorefinery concept for 2nd generation bioethanol production together with biogas production from the fermentation effluent was tested in pilot-scale. The pilot plant comprised pretreatment, enzymatic hydrolysis, hexose and pentose fermentation into ethanol and anaerobic digestion......-VS/(m3•d) a methane yield of 340 L/kg-VS was achieved for thermophilic operation while 270 L/kg-VS was obtained under mesophilic conditions. Thermophilic operation was, however, less robust towards further increase of the loading rate and for loading rates higher than 5 kg-VS/(m3•d) the yield was higher...... for mesophilic than for thermophilic operation. The effluent from the ethanol fermentation showed no signs of toxicity to the anaerobic microorganisms. Implementation of the biogas production from the fermentation effluent accounted for about 30% higher biofuels yield in the biorefinery compared to a system...

  14. Novel renewable products for biorefineries

    Science.gov (United States)

    A biorefinery integrates unit operations to convert biomass into a variety of biobased products, including fuels, chemicals, energy, and feed. Government policy initiatives over the last 1-2 decades have emphasized the production of biobased fuels, and consequently the number of dry-grind ethanol bi...

  15. Biorefineries: A Short Introduction.

    Science.gov (United States)

    Wagemann, Kurt; Tippkötter, Nils

    2018-04-13

    The terms bioeconomy and biorefineries are used for a variety of processes and developments. This short introduction is intended to provide a delimitation and clarification of the terminology as well as a classification of current biorefinery concepts. The basic process diagrams of the most important biorefinery types are shown.

  16. Ethanol Production by Soy Fiber Treatment and Simultaneous Saccharification and Co-Fermentation in an Integrated Corn-Soy Biorefinery

    Directory of Open Access Journals (Sweden)

    Jasreen K. Sekhon

    2018-05-01

    Full Text Available Insoluble fiber (IF recovered from the enzyme-assisted aqueous extraction process (EAEP of soybeans is a fraction rich in carbohydrates and proteins. It can be used to enhance ethanol production in an integrated corn-soy biorefinery, which combines EAEP with traditional corn-based ethanol processing. The present study evaluated IF as a substrate for ethanol production. The effects of treatment of IF (soaking in aqueous ammonia (SAA, liquid hot water (LHW, and enzymatic hydrolysis, primarily simultaneous saccharification and co-fermentation (SSCF, as well as scaling up (250 mL to 60 L on ethanol production from IF alone or a corn and IF slurry were investigated. Enzymatic hydrolysis (pectinase, cellulase, and xylanase, each added at 5% soy solids during simultaneous saccharification and fermentation/SSCF was the best treatment to maximize ethanol production from IF. Ethanol yield almost doubled when SSCF of IF was performed with Saccharomyces cerevisiae and Escherichia coli KO11. Addition of IF in dry-grind corn fermentation increased the ethanol production rate (~31%, but low ethanol tolerance of E. coli KO11 was a limiting factor for employing SSCF in combination corn and IF fermentation. Nonlinear Monod modeling accurately predicted the effect of ethanol concentration on E. coli KO11 growth kinetics by Hanes-Woolf linearization. Collectively, the results from this study suggest a potential of IF as a substrate, alone or in dry-grind corn fermentation, where it enhances the ethanol production rate. IF can be incorporated in the current bioethanol industry with no added capital investment, except enzymes.

  17. Biorefineries: Current activities and future developments

    Energy Technology Data Exchange (ETDEWEB)

    Demirbas, Ayhan [Sila Science, Trabzon (Turkey)

    2009-11-15

    This paper reviews the current refuel valorization facilities as well as the future importance of biorefineries. A biorefinery is a facility that integrates biomass conversion processes and equipment to produce fuels, power, and chemicals from biomass. Biorefineries combine the necessary technologies of the biorenewable raw materials with those of chemical intermediates and final products. Char production by pyrolysis, bio-oil production by pyrolysis, gaseous fuels from biomass, Fischer-Tropsch liquids from biomass, hydrothermal liquefaction of biomass, supercritical liquefaction, and biochemical processes of biomass are studied and concluded in this review. Upgraded bio-oil from biomass pyrolysis can be used in vehicle engines as fuel. (author)

  18. Biorefineries: Current activities and future developments

    International Nuclear Information System (INIS)

    Demirbas, Ayhan

    2009-01-01

    This paper reviews the current refuel valorization facilities as well as the future importance of biorefineries. A biorefinery is a facility that integrates biomass conversion processes and equipment to produce fuels, power, and chemicals from biomass. Biorefineries combine the necessary technologies of the biorenewable raw materials with those of chemical intermediates and final products. Char production by pyrolysis, bio-oil production by pyrolysis, gaseous fuels from biomass, Fischer-Tropsch liquids from biomass, hydrothermal liquefaction of biomass, supercritical liquefaction, and biochemical processes of biomass are studied and concluded in this review. Upgraded bio-oil from biomass pyrolysis can be used in vehicle engines as fuel.

  19. Integrating uncertainties to the combined environmental and economic assessment of algal biorefineries: A Monte Carlo approach.

    Science.gov (United States)

    Pérez-López, Paula; Montazeri, Mahdokht; Feijoo, Gumersindo; Moreira, María Teresa; Eckelman, Matthew J

    2018-06-01

    The economic and environmental performance of microalgal processes has been widely analyzed in recent years. However, few studies propose an integrated process-based approach to evaluate economic and environmental indicators simultaneously. Biodiesel is usually the single product and the effect of environmental benefits of co-products obtained in the process is rarely discussed. In addition, there is wide variation of the results due to inherent variability of some parameters as well as different assumptions in the models and limited knowledge about the processes. In this study, two standardized models were combined to provide an integrated simulation tool allowing the simultaneous estimation of economic and environmental indicators from a unique set of input parameters. First, a harmonized scenario was assessed to validate the joint environmental and techno-economic model. The findings were consistent with previous assessments. In a second stage, a Monte Carlo simulation was applied to evaluate the influence of variable and uncertain parameters in the model output, as well as the correlations between the different outputs. The simulation showed a high probability of achieving favorable environmental performance for the evaluated categories and a minimum selling price ranging from $11gal -1 to $106gal -1 . Greenhouse gas emissions and minimum selling price were found to have the strongest positive linear relationship, whereas eutrophication showed weak correlations with the other indicators (namely greenhouse gas emissions, cumulative energy demand and minimum selling price). Process parameters (especially biomass productivity and lipid content) were the main source of variation, whereas uncertainties linked to the characterization methods and economic parameters had limited effect on the results. Copyright © 2018 Elsevier B.V. All rights reserved.

  20. Economic and environmental assessment of n-butanol production in an integrated first and second generation sugarcane biorefinery: Fermentative versus catalytic routes

    International Nuclear Information System (INIS)

    Pereira, L.G.; Dias, M.O.S.; Mariano, A.P.; Maciel Filho, R.; Bonomi, A.

    2015-01-01

    Highlights: • Financial and environmental impacts of n-butanol production were investigated. • Analysis showed promising economic results for ABE fermentation scenarios. • Ethanol catalysis to butanol presented discouraging figures. • n-Butanol use as fuel demonstrated favorable GHG emissions results. - Abstract: n-Butanol produced from renewable resources has attracted increasing interest, mostly for its potential use as liquid biofuel for transportation. Process currently used in the industry (Acetone–Butanol–Ethanol fermentation – ABE) faces major technical challenges, which could be overcome by an alternative production through ethanol catalysis. In this study, both routes are evaluated by means of their financial viabilities and environmental performance assessed through the Virtual Sugarcane Biorefinery methodological framework. Comparative financial analysis of the routes integrated to a first and second generation sugarcane biorefinery shows that, despite the drawbacks, ABE process for fermentation of the pentoses liquor is more attractive than the catalysis of ethanol to n-butanol and co-products. n-Butanol use as fuel demonstrated favorable environmental results for climate change as figures showed over 50% reduction in greenhouse gas emission compared with gasoline.

  1. Forest biorefinery : the next century of innovation

    Science.gov (United States)

    Junyong Zhu

    2011-01-01

    The concept of producing cel¬lulosic biofuel, bioproducts, and chemicals using ligno¬celluloses in a biorefinery has been around for over a century. Renewed interest in the biorefinery concept has more recently arisen from concerns about climate change and the depletion of fossil fuels. Much research and progress has been made in the last three decades in the area of...

  2. Waste Biorefinery: A New Paradigm for a Sustainable Bioelectro Economy.

    Science.gov (United States)

    Mohan, S Venkata; Butti, Sai Kishore; Amulya, K; Dahiya, Shikha; Modestra, J Annie

    2016-11-01

    A waste biorefinery is a means to valorize waste as a renewable feedstock to recover biobased materials and energy through sustainable biotechnology. This approach holistically integrates remediation and resource recovery. Here we discuss the various technologies employable to construct a waste biorefinery platform and its place in a biobased economy. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Biorefineries: from concepts to reality?

    Energy Technology Data Exchange (ETDEWEB)

    Wagemann, K. [DECHEMA e.V., Frankfurt am Main (Germany)

    2007-07-01

    The concept of biorefineries addresses the conversion of plant biomass to fuels, materials and chemicals, waste streams being minimized and used for the production of electricity and heat. Four different types are presently discussed: - Sugar-based biorefineries - Whole-crop biorefineries - Green biorefineries - Lignocellulose biorefineries Besides the lack of existing technical solutions and limited land resources, competition with food production and, as a consequence, rising raw material prices considered. (orig.)

  4. Biorefineries. Prerequisite for the realization of a future bioeconomy

    Energy Technology Data Exchange (ETDEWEB)

    Wagemann, K. [DECHEMA e.V., Frankfurt am Main (Germany)

    2012-07-01

    The current discussion on how to establish a bioeconomy aims in particular at a significant increase of the share of renewable raw materials in the feedstock pool for the production of chemicals and materials; this share currently is around 12%. Such products can be intermediate chemicals, presently already produced from petroleum. Other chemicals, which can be components of new value chains, are also being discussed. In addition materials like biopolymers are already used directly in consumer goods. These considerations imply a higher demand on renewable raw materials especially from plants. Biorefineries will play an important role in meeting this demand. The German Government has decided to draw up a roadmap being established by a group of independent experts from industry and academia. This roadmap describes in a systematic way status and perspectives of the different biorefinery concepts. It takes economic and ecological aspects into considerations and analyses the R and D demand. The following definition is taken as a basis for the analysis: 'A biorefinery is characterised by having a dedicated, integrative overall approach, using biomass as a versatile raw material source for the sustainable production of a spectrum of different intermediates and marketable products (chemicals, materials, bioenergy and food/feed co-products) by using the biomass components as complete as possible.' The analysis considers the following promising concepts: - Sugar biorefinery and Starch biorefinery; - Plant oil biorefinery including Algae lipid biorefinery; - Lignocellulose (Cellulose/Hemicellulose/Lignin) biorefinery including Green (green fibre/green juice) biorefinery; - Synthesis gas biorefinery; - Biogas biorefinery. The roadmap analyses the strengths, weaknesses, opportunities and threats of the different concepts. For several specific examples preliminary economical and ecological assessment were carried out. The lecture will also give examples how these

  5. Fostering Integrity in Research

    Science.gov (United States)

    McNutt, M. K.

    2017-12-01

    The responsible conduct of research requires that all involved in the research enterprise - researchers, sponsors, reviewers, publishers, and communicators - adhere to a set of integrity principles to protect the public's investment. Given the increasing complexity and globalization of the research enterprise, the National Academies recently re-examined and updated its integrity recommendations for researchers in the report Fostering Integrity in Research, with sponsorship from the National Science Foundation. Major departures from the previous recommendations 25-years earlier are the recognition that practices that were previously classified as merely questionable are indeed detrimental to the responsible conduct of research. Furthermore, the report concludes that there has been insufficient effort to respond to the threats that lapses in research integrity pose to the quality of research products and the reputation of researchers as deserving of the public trust. It recommends the creation of an independent, non-profit entity dedicated to promoting research integrity by serving as a resource and clearing house for expertise, advice, materials, and best practices on fostering research integrity and responding to allegations of research misconduct.

  6. Grid Integration Research | Wind | NREL

    Science.gov (United States)

    Grid Integration Research Grid Integration Research Researchers study grid integration of wind three wind turbines with transmission lines in the background. Capabilities NREL's grid integration electric power system operators to more efficiently manage wind grid system integration. A photo of

  7. Bioproducts fro biorefineries

    Science.gov (United States)

    Biorefineries of the future may convert biomass to fuels, chemicals, and materials that are provided today by petroleum refineries. Bioproducts are attractive because they could offer benefits of renewability, environmental and personal safety, and biodegradability or recyclability. However, a gre...

  8. Waste biorefineries: Enabling circular economies in developing countries.

    Science.gov (United States)

    Nizami, A S; Rehan, M; Waqas, M; Naqvi, M; Ouda, O K M; Shahzad, K; Miandad, R; Khan, M Z; Syamsiro, M; Ismail, I M I; Pant, Deepak

    2017-10-01

    This paper aims to examine the potential of waste biorefineries in developing countries as a solution to current waste disposal problems and as facilities to produce fuels, power, heat, and value-added products. The waste in developing countries represents a significant source of biomass, recycled materials, chemicals, energy, and revenue if wisely managed and used as a potential feedstock in various biorefinery technologies such as fermentation, anaerobic digestion (AD), pyrolysis, incineration, and gasification. However, the selection or integration of biorefinery technologies in any developing country should be based on its waste characterization. Waste biorefineries if developed in developing countries could provide energy generation, land savings, new businesses and consequent job creation, savings of landfills costs, GHG emissions reduction, and savings of natural resources of land, soil, and groundwater. The challenges in route to successful implementation of biorefinery concept in the developing countries are also presented using life cycle assessment (LCA) studies. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Project Independence: Construction of an Integrated Biorefinery for Production of Renewable Biofuels at an Existing Pulp and Paper Mill

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, Douglas

    2012-06-01

    Project Independence proposed to construct a demonstration biomass-to-liquids (BTL) biorefinery in Wisconsin Rapids, isconsin. The biorefinery was to be co-located at the existing pulp and paper mill, NewPage Wisconsin System Incorporated’s Wisconsin Rapids Mill, and when in full operation would both generate renewable energy for Wisconsin Rapids Mill and produce liquid fuels from abundant and renewable lignocellulosic biomass. The biorefinery would serve to validate the thermochemical pathway and economic models for BTL production using forest residuals and wood waste, providing a basis for proliferating BTL conversion technologies throughout the United States. It was a project goal to create a compelling new business model for the pulp and paper industry, and support the nation’s goal for increasing renewable fuels production and reducing its dependence on foreign oil. NewPage Corporation planned to replicate this facility at other NewPage Corporation mills after this first demonstration scale plant was operational and had proven technical and economic feasibility. An overview of the process begins with biomass being harvested, sized, conditioned and fed into a ThermoChem Recovery International (TRI) steam reformer where it is converted to high quality synthetic gas (syngas). The syngas is then cleaned, compressed, scrubbed, polished and fed into the Fischer-Tropsch (F-T) catalytic reactors where the gas is converted into two, sulfur-free, clean crude products which will be marketed as revenue generating streams. Additionally, the Fischer-Tropsch products could be upgraded for use in automotive, aviation and chemical industries as valuable products, if desired. As the Project Independence project set out to prove forest products could be used to commercially produce biofuels, they planned to address and mitigate issues as they arose. In the early days of the Project Independence project, the plant was sized to process 500 dry tons of biomass per day but would

  10. [Promoting Research Integrity].

    Science.gov (United States)

    Suzuki, Hiromichi

    2018-01-01

     Japan Agency for Medical Research and Development (AMED) was launched in April 2015 to promote integrated medical research and development (R&D) ranging from basic research to practical applications, in order to smoothly achieve the nationwide application of research outcomes, and to establish an environment therefor. AMED consolidates budgets for R&D expenses, which had previously been allocated from different sources, such as the Ministry of Education, Culture, Sports, Science and Technology, the Ministry of Health, Labour and Welfare, and the Ministry of Economy, Trade and Industry. It provides funds strategically to universities, research institutions, etc. By promoting medical R&D, AMED aims to achieve the world's highest level of medical care/services to contribute to a society in which people live long and healthy lives. To achieve this mission, it is imperative that R&D funded by AMED is widely understood and supported. Maintaining and improving research integrity is a prerequisite to this end. AMED is taking various measures to ensure fair and appropriate R&D. It is asking researchers to participate in its responsible conduct in research (RCR) education program and to comply with its rules for managing conflicts of interest (COI). In addition, AMED also conducts a grant program to create and distribute a variety of educational materials on RCR and other matters. Further, AMED is establishing a platform that allows researchers to exchange information about research integrity, and it is undertaking additional measures, such as holding meetings and international symposia on research integrity.

  11. Engineering Cellulases for Biorefinery

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Manoj [Royal DSM, San Francisco, CA (United States)

    2010-06-27

    Lignocellulosic biomass is the most abundant, least expensive renewable natural biological resource for the production of biobased products and bioenergy is important for the sustainable development of human civilization in 21st century. For making the fermentable sugars from lignocellulosic biomass, a reduction in cellulase production cost, an improvement in cellulase performance, and an increase in sugar yields are all vital to reduce the processing costs of biorefineries. Improvements in specific cellulase activities for non-complexed cellulase mixtures can be implemented through cellulase engineering based on rational design or directed evolution for each cellulase component enzyme, as well as on the reconstitution of cellulase components. In this paper, we will provide DSM's efforts in cellulase research and developments and focus on limitations. Cellulase improvement strategies based on directed evolution using screening on relevant substrates, screening for higher thermal tolerance based on activity screening approaches such as continuous culture using insoluble cellulosic substrates as a powerful selection tool for enriching beneficial cellulase mutants from the large library. We will illustrate why and how thermostable cellulases are vital for economic delivery of bioproducts from cellulosic biomass using biochemical conversion approach.

  12. Product quality optimization in an integrated biorefinery: Conversion of pistachio nutshell biomass to biofuels and activated biochars via pyrolysis

    International Nuclear Information System (INIS)

    Işıtan, Seçil; Ceylan, Selim; Topcu, Yıldıray; Hintz, Chloe; Tefft, Juliann; Chellappa, Thiago; Guo, Jicheng; Goldfarb, Jillian L.

    2016-01-01

    Highlights: • Pyrolysis temperature key variable in manipulating biofuel quality. • Pyrolysis temperature does not impact activated biochar surface area. • Activation temperature key variable to optimize surface area of pistachio biochar. • Statistical model accurately predicts surface area of biochar, especially above 600 m"2/g. - Abstract: An economically viable transition to a renewable, sustainable energy future hinges on the ability to simultaneously produce multiple high value products from biomass precursors. Though there is considerable literature on the thermochemical conversion of biomass to biofuels and biochars, there are few holistic examinations that seek to understand trade-offs between biofuel quality and the associated pyrolysis conditions on activated carbons made from the resulting biochars. Using an Ordinary Least Squares regression analysis, this study probes the impact of pyrolysis and activation temperature on surface areas and pore volumes for 28 carbon dioxide-activated carbons. Activation temperature has the largest single impact of any other variable; increasing the temperature from 800 to 900 °C leads to an increase in surface area of more than 300 m"2/g. Contrary to some prior results, pyrolysis temperature has minimal effect on the resulting surface area and pore volume, suggesting that optimizing the temperature at which biofuels are extracted will have little impact on carbon dioxide-activated carbons. Increasing pyrolysis temperature increases methane formation but decreases gaseous hydrocarbons. Bio-oil obtained at lower pyrolysis temperatures shows fewer oxygenated compounds, indicating a greater stability, but higher pyrolysis temperatures maximize production of key biorefinery intermediaries such as furans. By analyzing data in such a holistic manner, it may be possible to optimize the production of biofuels and activated carbons from biomass by minimizing the amount of raw materials and energy necessary to maximize

  13. Biorefinery Sustainability Analysis

    DEFF Research Database (Denmark)

    J. S. M. Silva, Carla; Prunescu, Remus Mihail; Gernaey, Krist

    2017-01-01

    This chapter deals with sustainability analysis of biorefinery systems in terms of environmental and socio-economic indicators . Life cycle analysis has methodological issues related to the functional unit (FU), allocation , land use and biogenic carbon neutrality of the reference system and of t......This chapter deals with sustainability analysis of biorefinery systems in terms of environmental and socio-economic indicators . Life cycle analysis has methodological issues related to the functional unit (FU), allocation , land use and biogenic carbon neutrality of the reference system...... and of the biorefinery-based system. Socio-economic criteria and indicators used in sustainability frameworks assessment are presented and discussed. There is not one single methodology that can aptly cover the synergies of environmental, economic, social and governance issues required to assess the sustainable...

  14. Recovery Act: Beneficial CO{sub 2} Capture in an Integrated Algal Biorefinery for Renewable Generation and Transportation Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Lane, Christopher; Hampel, Kristin; Rismani-Yazdi, Hamid; Kessler, Ben; Moats, Kenneth; Park, Jonathan; Schwenk, Jacob; White, Nicholas; Bakhit, Anis; Bargiel, Jeff; Allnutt, F. C.

    2014-03-31

    DOE DE-FE0001888 Award, Phase 2, funded research, development, and deployment (RD&D) of Phycal’s pilot-scale, algae to biofuels, bioproducts, and processing facility in Hawai’i. Phycal’s algal-biofuel and bioproducts production system integrates several novel and mature technologies into a system that captures and reuses industrially produced carbon dioxide emissions, which would otherwise go directly to the atmosphere, for the manufacture of renewable energy products and bioproducts from algae (note that these algae are not genetically engineered). At the end of Phase 2, the project as proposed was to encompass 34 acres in Central Oahu and provide large open ponds for algal mass culturing, heterotrophic reactors for the Heteroboost™ process, processing facilities, water recycling facilities, anaerobic digestion facilities, and other integrated processes. The Phase 2 award was divided into two modules, Modules 1 & 2, where the Module 1 effort addressed critical scaling issues, tested highest risk technologies, and set the overall infrastructure needed for a Module 2. Phycal terminated the project prior to executing construction of the first Module. This Final Report covers the development research, detailed design, and the proposed operating strategy for Module 1 of Phase 2.

  15. Integration of a kraft pulping mill into a forest biorefinery: pre-extraction of hemicellulose by steam explosion versus steam treatment.

    Science.gov (United States)

    Martin-Sampedro, Raquel; Eugenio, Maria E; Moreno, Jassir A; Revilla, Esteban; Villar, Juan C

    2014-02-01

    Growing interest in alternative and renewable energy sources has brought increasing attention to the integration of a pulp mill into a forest biorefinery, where other products could be produced in addition to pulp. To achieve this goal, hemicelluloses were extracted, either by steam explosion or by steam treatment, from Eucalyptus globulus wood prior to pulping. The effects of both pre-treatments in the subsequent kraft pulping and paper strength were evaluated. Results showed a similar degree of hemicelluloses extraction with both options (32-67% of pentosans), which increased with the severity of the conditions applied. Although both pre-treatments increased delignification during pulping, steam explosion was significantly better: 12.9 kappa number vs 22.6 for similar steam unexploded pulps and 40.7 for control pulp. Finally, similar reductions in paper strength were found regardless of the type of treatment and conditions assayed, which is attributed to the increase of curled and kinked fibers. Copyright © 2013 Elsevier Ltd. All rights reserved.

  16. Strategy and design of Innovation Policy Road Mapping for a waste biorefinery.

    Science.gov (United States)

    Rama Mohan, S

    2016-09-01

    Looming energy crisis, climate change concerns coupled with decreasing fossil fuel resources has garnered significant global attention toward development of alternative, renewable, carbon-neutral and eco-friendly fuels to fulfil burgeoning energy demands. Waste utilization and its management are being pursued with renewed interest due to the gamut of biobased products it can offer apart from providing enough energy to meet a major fraction of the world's energy demand. Biorefining is the sustainable processing of biomass into a spectrum of marketable products and energy. Integrating all components of waste treatment culminating into biobased products and energy recovery in a single integrated waste biorefinery is self sufficient, highly sustainable and is very beneficial. Designing systematic innovation policies are essential for development and commercialization of new technologies in this important futuristic research area. This communication explores Innovation Policy Road Mapping (IPRM) methodology available in the literature and applies it to design integrated waste biorefinery. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. A sustainable woody biomass biorefinery.

    Science.gov (United States)

    Liu, Shijie; Lu, Houfang; Hu, Ruofei; Shupe, Alan; Lin, Lu; Liang, Bin

    2012-01-01

    Woody biomass is renewable only if sustainable production is imposed. An optimum and sustainable biomass stand production rate is found to be one with the incremental growth rate at harvest equal to the average overall growth rate. Utilization of woody biomass leads to a sustainable economy. Woody biomass is comprised of at least four components: extractives, hemicellulose, lignin and cellulose. While extractives and hemicellulose are least resistant to chemical and thermal degradation, cellulose is most resistant to chemical, thermal, and biological attack. The difference or heterogeneity in reactivity leads to the recalcitrance of woody biomass at conversion. A selection of processes is presented together as a biorefinery based on incremental sequential deconstruction, fractionation/conversion of woody biomass to achieve efficient separation of major components. A preference is given to a biorefinery absent of pretreatment and detoxification process that produce waste byproducts. While numerous biorefinery approaches are known, a focused review on the integrated studies of water-based biorefinery processes is presented. Hot-water extraction is the first process step to extract value from woody biomass while improving the quality of the remaining solid material. This first step removes extractives and hemicellulose fractions from woody biomass. While extractives and hemicellulose are largely removed in the extraction liquor, cellulose and lignin largely remain in the residual woody structure. Xylo-oligomers, aromatics and acetic acid in the hardwood extract are the major components having the greatest potential value for development. Higher temperature and longer residence time lead to higher mass removal. While high temperature (>200°C) can lead to nearly total dissolution, the amount of sugars present in the extraction liquor decreases rapidly with temperature. Dilute acid hydrolysis of concentrated wood extracts renders the wood extract with monomeric sugars

  18. Biorefineries for chemical and biofuel production

    DEFF Research Database (Denmark)

    Fjerbæk Søtoft, Lene

    crops for biofuel production is research in biorefineries using a whole-crop approach with the aim of having an optimal use of all the components of the specific crop. Looking at rape as a model crop, the components can be used for i.e. bioethanol, biodiesel, biogas, biohydrogen, feed, food and plant...

  19. Design and Analysis of Offshore Macroalgae Biorefineries.

    Science.gov (United States)

    Golberg, Alexander; Liberzon, Alexander; Vitkin, Edward; Yakhini, Zohar

    2018-03-15

    Displacing fossil fuels and their derivatives with renewables, and increasing sustainable food production are among the major challenges facing the world in the coming decades. A possible, sustainable direction for addressing this challenge is the production of biomass and the conversion of this biomass to the required products through a complex system coined biorefinery. Terrestrial biomass and microalgae are possible sources; however, concerns over net energy balance, potable water use, environmental hazards, and uncertainty in the processing technologies raise questions regarding their actual potential to meet the anticipated food, feed, and energy challenges in a sustainable way. Alternative sustainable sources for biorefineries are macroalgae grown and processed offshore. However, implementation of the offshore biorefineries requires detailed analysis of their technological, economic, and environmental performance. In this chapter, the basic principles of marine biorefineries design are shown. The methods to integrate thermodynamic efficiency, investment, and environmental aspects are discussed. The performance improvement by development of new cultivation methods that fit macroalgae physiology and development of new fermentation methods that address macroalgae unique chemical composition is shown.

  20. Biorefinery.nl 2006 : the results of the 1st year of the Dutch Network on Biorefinery, BioRef 0606

    NARCIS (Netherlands)

    Zwart, R.W.R.; Ree, van R.; Annevelink, E.; Jong, de E.

    2006-01-01

    The Dutch Network on Biorefinery (Biorefinery.nl) is a joint initiative of the Energy research Centre of the Netherlands (ECN) and Wageningen University and Research Centre (WUR). It is meant to inform industry, research institutes, universities, NGOs, governments and the general public about

  1. Biofuels and the biorefinery concept

    International Nuclear Information System (INIS)

    Taylor, Gail

    2008-01-01

    Liquid fuels can be made by refining a range of biomass materials, including oil-rich and sugar-rich crops such as oil-seed rape and sugar beet, biomass that consists mainly of plant cell walls (second generation lignocellulosics), macro- and micro-alga, or material that would now be discarded as waste. This can include animal bi-products as well as waste wood and other resources. In the medium-term, plant cell (lignocellulosic) material is likely to be favoured as the feedstock for biorefineries because of its availability. The UK may make use of a number of these options because of its complex agricultural landscape. There are now a range of targets for biofuel use in the UK, although their environmental effects are disputed. The technology of refining these materials is well known. Possible outputs include biodiesel and bioethanol, both of which can be used as transport fuel. Other potential products include hydrogen, polymers and a wide range of value-added chemicals, making this technology important in a post-petrochemical world. Biorefineries could use cogeneration to produce electricity. The paper identifies a range of research and development priorities which must be met if this opportunity is to be exploited fully

  2. Chemistry in forest biorefineries II - BIORAFF II

    Energy Technology Data Exchange (ETDEWEB)

    Hupa, M. (Aabo Akademi, Turku (Finland). Process Chemistry Centre), Email: mhupa@abo.fi; Auer, M. (Aabo Akademi, Turku (Finland). Process Chemistry Centre), Email: mauer@abo.fi

    2010-10-15

    The biorefinery concept may be compared to an oil refinery and petrochemical plant, where fuels and numerous intermediates are produced for further processing into high-value and speciality materials. In biorefineries, the raw material instead of mineral oil is biobased material. Biorefinery development at the US and European level mostly covers the use of annual crops and other bio-based materials. However, in this project focus is on non-food materials primarily in industrial pulp and paper processes and this project is limited to forest-based biorefineries. The aim of the project is also to preserve the molecular structures created by the nature as much as possible, to explore new separation and purification methods and look at new applications in the areas such as: functional food, nutritional additives, functional additives in paper making, antioxidants, new biobased materials and biobased energy. As the area, in spite of efforts to limit it, is very large, we have selected to focus on a limited number of concretised projects, which to our knowledge are complementary with other efforts for promoting biorefinery concepts. As highlights about promising results are studies on extraction of wood and derivatisations of hemicelluloses. The goals here are twofold; we are looking for the additional functionalities for hemicelluloses and searching for new applications. Hemicelluloses in many applications would benefit from the modification of the structure, especially to improve compatibility and solubility in some applications. Research on metals in trees and fuels, release of elements in combustion, pyrolysis and sorption studies have produced new knowledge. (orig.)

  3. Chemistry in forest biorefineries II - BIORAFF II

    Energy Technology Data Exchange (ETDEWEB)

    Hupa, M.; Auer, M. (Aabo Akademi University, Turku (Finland), Process Chemistry Centre), e-mail: mhupa@abo.fi, e-mail: mauer@abo.fi

    2011-11-15

    The biorefinery concept may be compared to an oil refinery and petrochemical plant, where fuels and numerous intermediates are produced for further processing into high-value and speciality materials. In biorefineries, the raw material instead of mineral oil is bio-based material. Biorefinery development at the US and European level mostly covers the use of annual crops and other bio-based materials. However, in this project focus is on non-food materials primarily in industrial pulp and paper processes and this project is limited to forest-based biorefineries. The aim of the project is also to preserve the molecular structures created by the nature as much as possible, to explore new separation and purification methods and look at new applications in the areas such as: functional food, nutritional additives, functional additives in paper making, antioxidants, new biobased materials and biobased energy. As the area, in spite of efforts to limit it, is very large, we have selected to focus on a limited number of concretised projects, which to our knowledge are complementary with other efforts for promoting biorefinery concepts. As highlights about promising results are studies on extraction of wood and derivatisations of hemicelluloses. The goals here are twofold; we are looking for the additional functionalities for hemicelluloses and search of new applications. Hemicelluloses in many applications would benefit from the modification of the structure, especially to improve compatibility and solubility in some applications. Research on metals in trees and fuels, release of elements in combustion, pyrolysis and sorption studies have produced new knowledge. (orig.)

  4. Process economics of renewable biorefineries: butanol and ethanol production in integrated bioprocesses from lignocellulosics and other industrial by-products

    Science.gov (United States)

    This chapter provides process economic details on production of butanol from lignocellulosic biomass and glycerol in integrated bioreactors where numerous unit operations are combined. In order to compare various processes, economic evaluations were performed using SuperPro Designer Software (versio...

  5. To The Biorefinery: Delivered Forestland and Agricultural Resources

    Energy Technology Data Exchange (ETDEWEB)

    None

    2016-06-01

    It can be challenging and costly to transport biomass feedstock supplies from the roadside, or farmgate, to a biorefinery. Given the geographic dispersion and lowbulk density of cellulosic feedstocks, cost effective scaling of commercial biorefinery operations requires overcoming many challenges. The Biomass Research and Development Board’s Feedstock Logistics Interagency Working Group identified four primary barriers related to biorefinery commercialization: • Capacity and efficiency of harvest and collection equipment • High-moisture content leading to degradation of biomass • Variable biomass quality upon arrival at the biorefinery • Costly transportation options.1 Further, feedstock supply systems do not currently mitigate risks such as low crop yield, fire, or competition for resource use. Delivery and preprocessing improvements will allow for the development of a commercial-scale bioenergy industry that achieves national production and cost targets.

  6. Valorization of lignin and cellulose in acid-steam-exploded corn stover by a moderate alkaline ethanol post-treatment based on an integrated biorefinery concept.

    Science.gov (United States)

    Yang, Sheng; Zhang, Yue; Yue, Wen; Wang, Wei; Wang, Yun-Yan; Yuan, Tong-Qi; Sun, Run-Cang

    2016-01-01

    Due to the unsustainable consumption of fossil resources, great efforts have been made to convert lignocellulose into bioethanol and commodity organic compounds through biological methods. The conversion of cellulose is impeded by the compactness of plant cell wall matrix and crystalline structure of the native cellulose. Therefore, appropriate pretreatment and even post-treatment are indispensable to overcome this problem. Additionally, an adequate utilization of coproduct lignin will be important for improving the economic viability of modern biorefinery industries. The effectiveness of moderate alkaline ethanol post-treatment on the bioconversion efficiency of cellulose in the acid-steam-exploded corn stover was investigated in this study. Results showed that an increase of the alcoholic sodium hydroxide (NaOH) concentration from 0.05 to 4% led to a decrease in the lignin content in the post-treated samples from 32.8 to 10.7%, while the cellulose digestibility consequently increased. The cellulose conversion of the 4% alcoholic NaOH integrally treated corn stover reached up to 99.3% after 72 h, which was significantly higher than that of the acid steam exploded corn stover without post-treatment (57.3%). In addition to the decrease in lignin content, an expansion of cellulose I lattice induced by the 4% alcoholic NaOH post-treatment played a significant role in promoting the enzymatic hydrolysis of corn stover. More importantly, the lignin fraction (AL) released during the 4% alcoholic NaOH post-treatment and the lignin-rich residue (EHR) remained after the enzymatic hydrolysis of the 4% alcoholic NaOH post-treated acid-steam-exploded corn stover were employed to synthesize lignin-phenol-formaldehyde (LPF) resins. The plywoods prepared with the resins exhibit satisfactory performances. An alkaline ethanol system with an appropriate NaOH concentration could improve the removal of lignin and modification of the crystalline structure of cellulose in acid

  7. University of Maine Integrated Forest Product Refinery (IFPR) Technology Research

    Energy Technology Data Exchange (ETDEWEB)

    Pendse, Hemant P.

    2010-11-23

    This project supported research on science and technology that forms a basis for integrated forest product refinery for co-production of chemicals, fuels and materials using existing forest products industry infrastructure. Clear systems view of an Integrated Forest Product Refinery (IFPR) allowed development of a compelling business case for a small scale technology demonstration in Old Town ME for co-production of biofuels using cellulosic sugars along with pulp for the new owners of the facility resulting in an active project on Integrated Bio-Refinery (IBR) at the Old Town Fuel & Fiber. Work on production of advanced materials from woody biomass has led to active projects in bioplastics and carbon nanofibers. A lease for 40,000 sq. ft. high-bay space has been obtained to establish a Technology Research Center for IFPR technology validation on industrially relevant scale. UMaine forest bioproducts research initiative that began in April 2006 has led to establishment of a formal research institute beginning in March 2010.

  8. Microalgae biorefineries: The Brazilian scenario in perspective.

    Science.gov (United States)

    Brasil, B S A F; Silva, F C P; Siqueira, F G

    2017-10-25

    Biorefineries have the potential to meet a significant part of the growing demand for energy, fuels, chemicals and materials worldwide. Indeed, the bio-based industry is expected to play a major role in energy security and climate change mitigation during the 21th century. Despite this, there are challenges related to resource consumption, processing optimization and waste minimization that still need to be overcome. In this context, microalgae appear as a promising non-edible feedstock with advantages over traditional land crops, such as high productivity, continuous harvesting throughout the year and minimal problems regarding land use. Importantly, both cultivation and microalgae processing can take place at the same site, which increases the possibilities for process integration and a reduction in logistic costs at biorefinery facilities. This review describes the actual scenario for microalgae biorefineries integration to the biofuels and petrochemical industries in Brazil, while highlighting the major challenges and recent advances in microalgae large-scale production. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. IEA Bioenergy Task 42 - Countries report. IEA Bioenergy Task 42 on biorefineries: Co-production of fuels, chemicals, power and materials from biomass. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Cherubini, F.; Jungmeier, G.; Mandl, M. (Joanneum Research, Graz (Austria)) (and others)

    2010-07-01

    This report has been developed by the members of IEA Bioenergy Task 42 on Biorefinery: Co-production of Fuels, Chemicals, Power and Materials from Biomass (www.biorefinery.nl/ieabioenergy-task42). IEA Bioenergy is a collaborative network under the auspices of the International Energy Agency (IEA) to improve international cooperation and information exchange between national bioenergy RD and D programs. IEA Bioenergy Task 42 on Biorefinery covers a new and very broad biomass-related field, with a very large application potential, and deals with a variety of market sectors with many interested stakeholders, a large number of biomass conversion technologies, and integrated concepts of both biochemical and thermochemical processes. This report contains an overview of the biomass, bioenergy and biorefinery situation, and activities, in the Task 42 member countries: Austria, Canada, Denmark, France, Germany, Ireland, and the Netherlands. The overview includes: national bioenergy production, non-energetic biomass use, bioenergy related policy goals, national oil refineries, biofuels capacity for transport purposes, existing biorefinery industries, pilot and demo plants, and other activities of research and development (such as main national projects and stakeholders). Data are provided by National Task Leaders (NTLs), whose contact details are listed at the end of the report. (author)

  10. From tiny microalgae to huge biorefineries

    OpenAIRE

    Gouveia, L.

    2014-01-01

    Microalgae are an emerging research field due to their high potential as a source of several biofuels in addition to the fact that they have a high-nutritional value and contain compounds that have health benefits. They are also highly used for water stream bioremediation and carbon dioxide mitigation. Therefore, the tiny microalgae could lead to a huge source of compounds and products, giving a good example of a real biorefinery approach. This work shows and presents examples of experimental...

  11. Process Intensification for Cellulosic Biorefineries.

    Science.gov (United States)

    Sadula, Sunitha; Athaley, Abhay; Zheng, Weiqing; Ierapetritou, Marianthi; Saha, Basudeb

    2017-06-22

    Utilization of renewable carbon source, especially non-food biomass is critical to address the climate change and future energy challenge. Current chemical and enzymatic processes for producing cellulosic sugars are multistep, and energy- and water-intensive. Techno-economic analysis (TEA) suggests that upstream lignocellulose processing is a major hurdle to the economic viability of the cellulosic biorefineries. Process intensification, which integrates processes and uses less water and energy, has the potential to overcome the aforementioned challenges. Here, we demonstrate a one-pot depolymerization and saccharification process of woody biomass, energy crops, and agricultural residues to produce soluble sugars with high yields. Lignin is separated as a solid for selective upgrading. Further integration of our upstream process with a reactive extraction step makes energy-efficient separation of sugars in the form of furans. TEA reveals that the process efficiency and integration enable, for the first time, economic production of feed streams that could profoundly improve process economics for downstream cellulosic bioproducts. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Biorefinery plant design, engineering and process optimisation

    DEFF Research Database (Denmark)

    Holm-Nielsen, Jens Bo; Ehimen, Ehiazesebhor Augustine

    2014-01-01

    Before new biorefinery systems can be implemented, or the modification of existing single product biomass processing units into biorefineries can be carried out, proper planning of the intended biorefinery scheme must be performed initially. This chapter outlines design and synthesis approaches...... applicable for the planning and upgrading of intended biorefinery systems, and includes discussions on the operation of an existing lignocellulosic-based biorefinery platform. Furthermore, technical considerations and tools (i.e., process analytical tools) which could be applied to optimise the operations...... of existing and potential biorefinery plants are elucidated....

  13. Sustainability assessment of sugarcane biorefinery and molasses ethanol production in Thailand using eco-efficiency indicator

    International Nuclear Information System (INIS)

    Silalertruksa, Thapat; Gheewala, Shabbir H.; Pongpat, Patcharaporn

    2015-01-01

    Highlights: • Sugarcane biorefinery in Thailand is evaluated using the eco-efficiency concept. • Green cane along with cane trash use for electricity yields highest eco-efficiency. • Proposed biorefinery system increases eco-efficiency by 20–70%. - Abstract: The study aims to evaluate the sugarcane biorefinery and molasses ethanol production in Thailand using the combined environmental and economic sustainability indicator, so called “Eco-efficiency”. Four sugarcane biorefinery scenarios in Thailand are evaluated. The total output values (US$) and the life cycle greenhouse gas (GHG) emissions (kg CO_2eq) are selected as the indicators for characterizing economic and environmental performance, respectively. The results show that the biorefinery system of mechanized farming along with cane trash utilization for power generation yields the highest eco-efficiency. The benefits come from the increased value added of the biorefinery together with the decreased GHG emissions of the biorefinery system. As compared to the base case scenario, the new systems proposed result in the eco-efficiency improvement by around 20–70%. The biorefinery concept induces reduction of GHG emissions attributed to molasses ethanol. Green cane production and harvesting results in further lowering of the GHG emissions. Integration of sugarcane biomass utilization across the entire sugarcane complex would enhance the sustainability of the sugarcane production system.

  14. A methodology to assess the contribution of biorefineries to a sustainable bio-based economy

    International Nuclear Information System (INIS)

    Maga, Daniel

    2015-01-01

    Within this thesis for the first time an integrative methodology to assess the sustainability of biorefineries and bio-based products has been developed which is based on a fundamental understanding of sustainability as presented in the Brundtland report. The applied integrative concept of sustainability as developed by the Institute for Technology Assessment and Systems Analysis (ITAS) overcomes the widespread thinking in three pillars of sustainability and opens up new perspectives. The methodology developed addresses innovative life cycle assessment evaluation methods on midpoint level as well as on the area of protection and adopts state-of-the-art assessment procedures e.g. to determine water deprivation. It goes far beyond the scope of conventional LCA studies and examines effects on human health, on the environment, on the development of knowledge and physical capital, and on regional development and acceptance. In order to validate the developed method it was applied to an algae biorefinery currently under development and construction in the south of Spain. For this assessment for the first time extensive process data was collected of a real algae biorefinery which uses municipal waste water as a culture medium for microalgae. The use of waste water allows to reduce the demand for fresh water and avoids additional fertilisation of microalgae. Moreover, the analysed algae biorefinery replaces conventional waste water treatment by a biological purification and produces biogas by an anaerobic pretreatment of waste water as well as by anaerobic digestion of algae. After several purification steps the biogas can be used as automotive fuel and thus contributes to further development and increased use of biofuels. On the one hand the sustainability assessment shows that this way of waste water treatment contributes to climate protection and to the conservation of fossil energy carrier. On the other hand approximately ten times more land is needed and twenty times

  15. A methodology to assess the contribution of biorefineries to a sustainable bio-based economy

    Energy Technology Data Exchange (ETDEWEB)

    Maga, Daniel

    2015-07-01

    Within this thesis for the first time an integrative methodology to assess the sustainability of biorefineries and bio-based products has been developed which is based on a fundamental understanding of sustainability as presented in the Brundtland report. The applied integrative concept of sustainability as developed by the Institute for Technology Assessment and Systems Analysis (ITAS) overcomes the widespread thinking in three pillars of sustainability and opens up new perspectives. The methodology developed addresses innovative life cycle assessment evaluation methods on midpoint level as well as on the area of protection and adopts state-of-the-art assessment procedures e.g. to determine water deprivation. It goes far beyond the scope of conventional LCA studies and examines effects on human health, on the environment, on the development of knowledge and physical capital, and on regional development and acceptance. In order to validate the developed method it was applied to an algae biorefinery currently under development and construction in the south of Spain. For this assessment for the first time extensive process data was collected of a real algae biorefinery which uses municipal waste water as a culture medium for microalgae. The use of waste water allows to reduce the demand for fresh water and avoids additional fertilisation of microalgae. Moreover, the analysed algae biorefinery replaces conventional waste water treatment by a biological purification and produces biogas by an anaerobic pretreatment of waste water as well as by anaerobic digestion of algae. After several purification steps the biogas can be used as automotive fuel and thus contributes to further development and increased use of biofuels. On the one hand the sustainability assessment shows that this way of waste water treatment contributes to climate protection and to the conservation of fossil energy carrier. On the other hand approximately ten times more land is needed and twenty times

  16. Nordic Migration and Integration Research

    OpenAIRE

    Pyrhönen, Niko; Martikainen, Tuomas; Leinonen, Johanna

    2017-01-01

    EXECUTIVE SUMMARY Migration and integration are currently highly contentious topics in political, public and scientific arenas, and will remain so in the near future. However, many common migration-related prejudices and inefficien¬cies in the integration of the migrant population are due to the lack of sound, tested and accessible scientific research. Therefore, the study of migration – by developing basic research and by properly resourcing novel methodological approaches and interventions ...

  17. A New Proposal Of Cellulosic Ethanol To Boost Sugarcane Biorefineries: Techno-economic Evaluation

    OpenAIRE

    Albarelli J.Q.; Ensinas A.V.; Silva M.A.

    2014-01-01

    Commercial simulator Aspen Plus was used to simulate a biorefinery producing ethanol from sugarcane juice and second generation ethanol production using bagasse fine fraction composed of parenchyma cells (P-fraction). Liquid hot water and steam explosion pretreatment technologies were evaluated. The processes were thermal and water integrated and compared to a biorefinery producing ethanol from juice and sugarcane bagasse. The results indicated that after thermal and water integration, the ev...

  18. Cell disruption for microalgae biorefineries.

    Science.gov (United States)

    Günerken, E; D'Hondt, E; Eppink, M H M; Garcia-Gonzalez, L; Elst, K; Wijffels, R H

    2015-01-01

    Microalgae are a potential source for various valuable chemicals for commercial applications ranging from nutraceuticals to fuels. Objective in a biorefinery is to utilize biomass ingredients efficiently similarly to petroleum refineries in which oil is fractionated in fuels and a variety of products with higher value. Downstream processes in microalgae biorefineries consist of different steps whereof cell disruption is the most crucial part. To maintain the functionality of algae biochemicals during cell disruption while obtaining high disruption yields is an important challenge. Despite this need, studies on mild disruption of microalgae cells are limited. This review article focuses on the evaluation of conventional and emerging cell disruption technologies, and a comparison thereof with respect to their potential for the future microalgae biorefineries. The discussed techniques are bead milling, high pressure homogenization, high speed homogenization, ultrasonication, microwave treatment, pulsed electric field treatment, non-mechanical cell disruption and some emerging technologies. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. Unconventional biomasses as feedstocks for production of biofuels and succinic acid in a biorefinery concept

    DEFF Research Database (Denmark)

    Gunnarsson, Ingólfur Bragi

    composition of the specific biomass feedstock, as well as which pretreatment, saccharification, fermentation and extraction techniques are used. Furthermore, integrating biological processes into the biorefinery that effectively consume CO2 will become increasingly important. Such process integration could...... significantly improve the sustainability indicators of the overall biorefinery process. In this study, unconventional lignocellulosic- and aquatic biomasses were investigated as biorefinery feedstocks. The studied biomasses were Jerusalem artichoke, industrial hemp and macroalgae species Laminaria digitata....... The chemical composition of biomasses was determined in order to demonstrate their biorefinery potential. Bioethanol and biogas along with succinic acid production were the explored bioconversion routes, while potential production of other compounds was also investigated. Differences and changes in biomass...

  20. Assessment of a novel alder biorefinery concept to meet demands of economic feasibility, energy production and long term environmental sustainability

    DEFF Research Database (Denmark)

    Thomsen, Tobias; Ahrenfeldt, Jesper; Thomsen, Sune Tjalfe

    2013-01-01

    A biorefinery concept based on alder tree plantations on degenerated soil is developed to comply with indicators of economic feasibility, fossil fuel depletion concerns, and long term sustainability issues. The potential performance of feedstock and biorefinery has been assessed through a literat......A biorefinery concept based on alder tree plantations on degenerated soil is developed to comply with indicators of economic feasibility, fossil fuel depletion concerns, and long term sustainability issues. The potential performance of feedstock and biorefinery has been assessed through...... degenerated soils. Integrating a biomass handling system, an LTCFB gasifier, a diarylheptanoids production chain, an anaerobic digestion facility, a slow pyrolysis unit, gas upgrading and various system integration units, the biorefinery could obtain the following production characteristics accounted...

  1. Design of an Optimal Biorefinery

    DEFF Research Database (Denmark)

    Nawaz, Muhammad; Zondervan, Edwin; Woodley, John

    2011-01-01

    In this paper we propose a biorefinery optimization model that can be used to find the optimal processing route for the production of ethanol, butanol, succinic acid and blends of these chemicals with fossil fuel based gasoline. The approach unites transshipment models with a superstructure...

  2. Cell disruption for microalgae biorefineries

    NARCIS (Netherlands)

    Günerken, E.; Hondt, d' E.; Eppink, M.H.M.; Garcia-Gonzalez, L.; Elst, K.; Wijffels, R.H.

    2015-01-01

    Microalgae are a potential source for various valuable chemicals for commercial applications ranging from nutraceuticals to fuels. Objective in a biorefinery is to utilize biomass ingredients efficiently similarly to petroleum refineries in which oil is fractionated in fuels and a variety of

  3. Multi-Product Microalgae Biorefineries

    NARCIS (Netherlands)

    Lam, 't G.P.; Vermuë, M.H.; Eppink, M.H.M.; Wijffels, R.H.; Berg, van den C.

    2018-01-01

    Although microalgae are a promising biobased feedstock, industrial scale production is still far off. To enhance the economic viability of large-scale microalgae processes, all biomass components need to be valorized, requiring a multi-product biorefinery. However, this concept is still too

  4. Food waste biorefinery: Sustainable strategy for circular bioeconomy.

    Science.gov (United States)

    Dahiya, Shikha; Kumar, A Naresh; Shanthi Sravan, J; Chatterjee, Sulogna; Sarkar, Omprakash; Mohan, S Venkata

    2018-01-01

    Enormous quantity of food waste (FW) is becoming a global concern. To address this persistent problem, sustainable interventions with green technologies are essential. FW can be used as potential feedstock in biological processes for the generation of various biobased products along with its remediation. Enabling bioprocesses like acidogenesis, fermentation, methanogenesis, solventogenesis, photosynthesis, oleaginous process, bio-electrogenesis, etc., that yields various products like biofuels, platform chemicals, bioelectricity, biomaterial, biofertilizers, animal feed, etc can be utilized for FW valorisation. Integrating these bioprocesses further enhances the process efficiency and resource recovery sustainably. Adapting biorefinery strategy with integrated approach can lead to the development of circular bioeconomy. The present review highlights the various enabling bioprocesses that can be employed for the generation of energy and various commodity chemicals in an integrated approach addressing sustainability. The waste biorefinery approach for FW needs optimization of the cascade of the individual bioprocesses for the transformation of linear economy to circular bioeconomy. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Coproducts performances in biorefineries: Development of Claiming-based allocation models for environmental policy.

    Science.gov (United States)

    Gnansounou, Edgard

    2018-04-01

    This study revisited the fundamentals of allocation to joint products and proposed new models for allocating common greenhouse gases emissions among coproducts of biorefineries. These emissions may account for more than 80% of the total emissions of greenhouse gases of the biorefineries. The proposed models optimize the reward of coproducts for their compliance to environmental requirements. They were illustrated by a case study of wheat straw biorefinery built on the literature. Several scenarios were considered with regard to the grain yield, field emissions of greenhouse gases, allocation between grain and straw and policy requirements. The results conform to the expectations and are sensitive to the policy targets and to the environmental performance of the counterpart system. Further research works are necessary to achieve a full application to complex processes. However, the proposed models are promising towards assessing the simultaneous compliance of coproducts of a biorefinery to environment policy requirements. Copyright © 2018 Elsevier Ltd. All rights reserved.

  6. Separation Technology - Making a difference in biorefineries

    NARCIS (Netherlands)

    Kiss, Anton Alexandru; Lange, Jean Paul; Schuur, Boelo; Brilman, Derk Willem Frederik; van der Ham, Aloysius G.J.; Kersten, Sascha R.A.

    2016-01-01

    In the quest for a sustainable bio-based economy, biorefineries play a central role as they involve the sustainable processing of biomass into marketable products and energy. This paper aims to provide a perspective on applications of separations that can make a great difference in biorefineries, by

  7. Pretreatment techniques for biofuels and biorefineries

    Energy Technology Data Exchange (ETDEWEB)

    Fang, Zhen (ed.) [Chinese Academy of Sciences, Kunming, YN (China). Xishuangbanna Tropical Botonical Garden

    2013-02-01

    The first book focused on pretreatment techniques for biofuels contributed by the world's leading experts. Extensively covers the different types of biomass, various pretreatment approaches and methods that show the subsequent production of biofuels and chemicals. In addition to traditional pretreatment methods, novel techniques are also introduced and discussed. An accessible reference work for students, researchers, academicians and industrialists in biorefineries. This book includes 19 chapters contributed by the world's leading experts on pretreatment methods for biomass. It extensively covers the different types of biomass (e.g. molasses, sugar beet pulp, cheese whey, sugarcane residues, palm waste, vegetable oil, straws, stalks and wood), various pretreatment approaches (e.g. physical, thermal, chemical, physicochemical and biological) and methods that show the subsequent production of biofuels and chemicals such as sugars, ethanol, extracellular polysaccharides, biodiesel, gas and oil. In addition to traditional methods such as steam, hot-water, hydrothermal, diluted-acid, organosolv, ozonolysis, sulfite, milling, fungal and bacterial, microwave, ultrasonic, plasma, torrefaction, pelletization, gasification (including biogas) and liquefaction pretreatments, it also introduces and discusses novel techniques such as nano and solid catalysts, organic electrolyte solutions and ionic liquids. This book offers a review of state-of-the-art research and provides guidance for the future paths of developing pretreatment techniques of biomass for biofuels, especially in the fields of biotechnology, microbiology, chemistry, materials science and engineering. It intends to provide a systematic introduction of pretreatment techniques. It is an accessible reference work for students, researchers, academicians and industrialists in biorefineries.

  8. Synthesis and design of optimal biorefinery

    DEFF Research Database (Denmark)

    Cheali, Peam

    analysed to enable risk-aware decision making. Theapplication of the developed analysis and decision support toolbox is highlightedthrough relevant biorefinery case studies: bioethanol, biogasoline or biodiesel production; algal biorefinery; and bioethanol-upgrading concepts are presented. This development...... environment. These challenges motivate thedevelopment of sustainable technologies for processing renewable feedstock for the production of fuels, chemicals and materials in what is commonly known as a biorefinery. The biorefinery concept is a term to describe one or more processes whichproduce various...... products from bio-based feedstock. Since there are several bio-basedfeedstock sources, this has motivated development of different conversion concepts producing various desired products. This results in a number of challenges for the synthesis and design of the optimal biorefinery concept at the early...

  9. Systems Integration | Photovoltaic Research | NREL

    Science.gov (United States)

    Integration Systems Integration The National Center for Photovoltaics (NCPV) at NREL provides grid integration support, system-level testing, and systems analysis for the Department of Energy's solar distributed grid integration projects supported by the SunShot Initiative. These projects address technical

  10. High impact biowastes from South European agro-industries as feedstock for second-generation biorefineries.

    Science.gov (United States)

    Scoma, Alberto; Rebecchi, Stefano; Bertin, Lorenzo; Fava, Fabio

    2016-01-01

    Availability of bio-based chemicals, materials and energy at reasonable cost will be one of the forthcoming issues for the EU economy. In particular, the development of technologies making use of alternative resources to fossil fuels is encouraged by the current European research and innovation strategy to face the societal challenge of natural resource scarcity, fossil resource dependence and sustainable economic growth. In this respect, second- generation biorefineries, i.e. biorefineries fed with biowastes, appear to be good candidates to substitute and replace the present downstream processing scheme. Contrary to first-generation biorefineries, which make use of dedicated crops or primary cultivations to achieve such a goal, the former employ agricultural, industrial, zootechnical, fishery and forestry biowastes as the main feedstock. This leaves aside any ethical and social issue generated by first-generation approaches, and concomitantly prevents environmental and economical issues associated with the disposal of the aforementioned leftovers. Unfortunately, to date, a comprehensive and updated mapping of the availability and potential use of bioresources for second-generation biorefineries in Europe is missing. This is a lack that severely limits R&D and industrial applications in the sector. On the other hand, attempts at valorizing the most diverse biowastes dates back to the nineteenth century and plenty of information in the literature on their sustainable exploitation is available. However, the large majority of these investigations have been focused on single fractions of biowastes or single steps of biowaste processing, preventing considerations on an integrated and modular (cascade) approach for the whole valorization of organic leftovers. This review aims at addressing these issues by gathering recent data on (a) some of the main high-impact biowastes located in Europe and in particular in its Southern part, and (b) the bio-based chemicals, materials

  11. Water-based woody biorefinery.

    Science.gov (United States)

    Amidon, Thomas E; Liu, Shijie

    2009-01-01

    The conversion of biomass into chemicals and energy is essential in order to sustain our present way of life. Fossil fuels are currently the predominant energy source, but fossil deposits are limited and not renewable. Biomass is a reliable potential source of materials, chemicals and energy that can be replenished to keep pace with our needs. A biorefinery is a concept for the collection of processes used to convert biomass into materials, chemicals and energy. The biorefinery is a "catch and release" method for using carbon that is beneficial to both the environment and the economy. In this study, we discuss three elements of a wood-based biorefinery, as proposed by the SUNY College of Environmental Science and Forestry (ESF): hot-water extraction, hydrolysis, and membrane separation/concentration. Hemicelluloses are the most easily separable main component of woody biomass and thus form the bulk of the extracts obtained by hot-water extraction of woody biomass. Hot-water extraction is an important step in the processes of woody biomass and product generation, replacing alternative costly pre-treatment methods. The hydrolysis of hemicelluloses produces 5-carbon sugars (mainly xylose), 6-carbon sugars (mainly glucose and mannose), and acetic acid. The use of nano-filtration membranes is an efficient technology that can be employed to fractionate hot-water extracts and wood hydrolysate. The residual solid mass after hot-water extraction has a higher energy content and contains fewer easily degradable components. This allows for more efficient subsequent processing to convert cellulose and lignin into conventional products.

  12. Early‐Stage Capital Cost Estimation of Biorefinery Processes: A Comparative Study of Heuristic Techniques

    Science.gov (United States)

    Couturier, Jean‐Luc; Kokossis, Antonis; Dubois, Jean‐Luc

    2016-01-01

    Abstract Biorefineries offer a promising alternative to fossil‐based processing industries and have undergone rapid development in recent years. Limited financial resources and stringent company budgets necessitate quick capital estimation of pioneering biorefinery projects at the early stages of their conception to screen process alternatives, decide on project viability, and allocate resources to the most promising cases. Biorefineries are capital‐intensive projects that involve state‐of‐the‐art technologies for which there is no prior experience or sufficient historical data. This work reviews existing rapid cost estimation practices, which can be used by researchers with no previous cost estimating experience. It also comprises a comparative study of six cost methods on three well‐documented biorefinery processes to evaluate their accuracy and precision. The results illustrate discrepancies among the methods because their extrapolation on biorefinery data often violates inherent assumptions. This study recommends the most appropriate rapid cost methods and urges the development of an improved early‐stage capital cost estimation tool suitable for biorefinery processes. PMID:27484398

  13. Thermochemical biorefinery based on dimethyl ether as intermediate: Technoeconomic assessment

    International Nuclear Information System (INIS)

    Haro, P.; Ollero, P.; Villanueva Perales, A.L.; Gómez-Barea, A.

    2013-01-01

    Highlights: ► A thermochemical biorefinery based on bio-DME as intermediate is studied. ► The assessed concepts (12) lead to multi-product generation (polygeneration). ► In all concepts DME is converted by carbonylation or hydrocarbonylation. ► Rates of return are similar to or higher than plants producing a single product. -- Abstract: Thermochemical biorefinery based on dimethyl ether (DME) as an intermediate is studied. DME is converted into methyl acetate, which can either be hydrogenated to ethanol or sold as a co-product. Considering this option together with a variety of technologies for syngas upgrading, 12 different process concepts are analyzed. The considered products are ethanol, methyl acetate, H 2 , DME and electricity. The assessment of each alternative includes biomass pretreatment, gasification, syngas clean-up and conditioning, DME synthesis and conversion, product separation, and heat and power integration. A plant size of 500 MW th processing poplar chips is taken as a basis. The resulting energy efficiency to products ranges from 34.9% to 50.2%. The largest internal rate of return (28.74%) corresponds to a concept which produces methyl acetate, DME and electricity (exported to grid). A sensitivity analysis with respect to total plant investment (TPI), total operation costs (TOC) and market price of products was carried out. The overall conclusion is that, despite its greater complexity, this kind of thermochemical biorefinery is more profitable than thermochemical bioprocesses oriented to a single product.

  14. Energy and environmental analysis of a rapeseed biorefinery conversion process

    DEFF Research Database (Denmark)

    Boldrin, Alessio; Balzan, Alberto; Astrup, Thomas Fruergaard

    2013-01-01

    )-based environmental assessment of a Danish biorefinery system was carried out to thoroughly analyze and optimize the concept and address future research. The LCA study was based on case-specific mass and energy balances and inventory data, and was conducted using consequential LCA approach to take into account market...... mechanisms determining the fate of products, lost opportunities and marginal productions. The results show that introduction of enzymatic transesterification and improved oil extraction procedure result in environmental benefits compared to a traditional process. Utilization of rapeseed straw seems to have...... positive effects on the greenhouse gases (GHG) footprint of the biorefinery system, with improvements in the range of 9 % to 29 %, depending on the considered alternative. The mass and energy balances showed the potential for improvement of straw treatment processes (hydrothermal pre-treatment and dark...

  15. Recovery of agricultural nutrients from biorefineries.

    Science.gov (United States)

    Carey, Daniel E; Yang, Yu; McNamara, Patrick J; Mayer, Brooke K

    2016-09-01

    This review lays the foundation for why nutrient recovery must be a key consideration in design and operation of biorefineries and comprehensively reviews technologies that can be used to recover an array of nitrogen, phosphorus, and/or potassium-rich products of relevance to agricultural applications. Recovery of these products using combinations of physical, chemical, and biological operations will promote sustainability at biorefineries by converting low-value biomass (particularly waste material) into a portfolio of higher-value products. These products can include a natural partnering of traditional biorefinery outputs such as biofuels and chemicals together with nutrient-rich fertilizers. Nutrient recovery not only adds an additional marketable biorefinery product, but also avoids the negative consequences of eutrophication, and helps to close anthropogenic nutrient cycles, thereby providing an alternative to current unsustainable approaches to fertilizer production, which are energy-intensive and reliant on nonrenewable natural resource extraction. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Integrative NMR for biomolecular research

    International Nuclear Information System (INIS)

    Lee, Woonghee; Cornilescu, Gabriel; Dashti, Hesam; Eghbalnia, Hamid R.; Tonelli, Marco; Westler, William M.; Butcher, Samuel E.; Henzler-Wildman, Katherine A.; Markley, John L.

    2016-01-01

    NMR spectroscopy is a powerful technique for determining structural and functional features of biomolecules in physiological solution as well as for observing their intermolecular interactions in real-time. However, complex steps associated with its practice have made the approach daunting for non-specialists. We introduce an NMR platform that makes biomolecular NMR spectroscopy much more accessible by integrating tools, databases, web services, and video tutorials that can be launched by simple installation of NMRFAM software packages or using a cross-platform virtual machine that can be run on any standard laptop or desktop computer. The software package can be downloaded freely from the NMRFAM software download page ( http://pine.nmrfam.wisc.edu/download-packages.html http://pine.nmrfam.wisc.edu/download_packages.html ), and detailed instructions are available from the Integrative NMR Video Tutorial page ( http://pine.nmrfam.wisc.edu/integrative.html http://pine.nmrfam.wisc.edu/integrative.html ).

  17. Integrative NMR for biomolecular research

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Woonghee, E-mail: whlee@nmrfam.wisc.edu; Cornilescu, Gabriel; Dashti, Hesam; Eghbalnia, Hamid R.; Tonelli, Marco; Westler, William M.; Butcher, Samuel E.; Henzler-Wildman, Katherine A.; Markley, John L., E-mail: markley@nmrfam.wisc.edu [University of Wisconsin-Madison, National Magnetic Resonance Facility at Madison and Biochemistry Department (United States)

    2016-04-15

    NMR spectroscopy is a powerful technique for determining structural and functional features of biomolecules in physiological solution as well as for observing their intermolecular interactions in real-time. However, complex steps associated with its practice have made the approach daunting for non-specialists. We introduce an NMR platform that makes biomolecular NMR spectroscopy much more accessible by integrating tools, databases, web services, and video tutorials that can be launched by simple installation of NMRFAM software packages or using a cross-platform virtual machine that can be run on any standard laptop or desktop computer. The software package can be downloaded freely from the NMRFAM software download page ( http://pine.nmrfam.wisc.edu/download-packages.html http://pine.nmrfam.wisc.edu/download{sub p}ackages.html ), and detailed instructions are available from the Integrative NMR Video Tutorial page ( http://pine.nmrfam.wisc.edu/integrative.html http://pine.nmrfam.wisc.edu/integrative.html ).

  18. Building Technologies Research and Integration Center (BTRIC)

    Data.gov (United States)

    Federal Laboratory Consortium — The Building Technologies Research and Integration Center (BTRIC), in the Energy and Transportation Science Division (ETSD) of Oak Ridge National Laboratory (ORNL),...

  19. Biofilm based attached cultivation technology for microalgal biorefineries-A review.

    Science.gov (United States)

    Wang, Junfeng; Liu, Wen; Liu, Tianzhong

    2017-11-01

    The attached cultivation for microalga has many superiorities over the conventional aqua-suspend methods, which make it a promising pathway to supply feedstock for microalgae based bio-refinery attempts. In this review, the current reports on bioreactor, application, modeling, substratum material and engineering aspects were summarized and the future research and developments should be focused on the following aspects: 1) Build principles and guidelines for rational structure design by studying the relationship of physiological properties with typical structures and light regimes; 2) Set up theory foundation of substratum material selection by studying the physic-chemical properties of algal cells and substratum materials; 3) Further understanding the mass transfer behaviors of both CO 2 and nutrients in biofilm for enhanced growth rate and products accumulation; 4) New equipment and machines for inoculation, harvesting and moisture keeping should be developed and integrated with bioreactor structure. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Sugarcane biorefineries: Case studies applied to the Brazilian sugar–alcohol industry

    International Nuclear Information System (INIS)

    Renó, Maria Luiza Grillo; Olmo, Oscar Almazán del; Palacio, José Carlos Escobar; Lora, Electo Eduardo Silva; Venturini, Osvaldo José

    2014-01-01

    Highlights: • Advanced system of co-generation improves the energy performance of biorefineries. • Sugarcane straw as additional source of fuel in the biorefinery resulted positive. • The farming and transport of sugarcane cause the main environmental impacts. - Abstract: The use of biomasses is becoming increasingly appealing alternative, to give an partial solution lack of energy, with an ecofriendly approach, having on sugarcane a solid fundament; that receives the new and valuable complement of the innovative concept of the biorefineries it is productive installations, that can be summarized as to reach the higher overall yield from the raw materials, with the lowest environmental impact, at minimum energy input and giving the maximum of the energy output. The biorefinery is the true valuable option of a wide diversification, with by-products like the single cell protein and biogas from the distillery vinasse, new oxidants like methanol, second generation biofuels, biobutanol, etc. In this context this paper presents a study of five different configurations of biorefineries. Each case study being a system based on an autonomous distillery or sugar mill with an annexed distillery and coproduction of methanol from bagasse. The paper includes the use of sugarcane harvest residues (mainly straw) and a BIG–GT plant (Biomass Integrated Gasification–Gas Turbine) as alternatives to fulfill the energy demands of the complex

  1. Swedish Pulp Mill Biorefineries. A vision of future possibilities

    Energy Technology Data Exchange (ETDEWEB)

    Berntsson, Thore (Chamers Univ. of Technology, Goeteborg (Sweden)); Axegaard, Peter; Backlund, Birgit; Samuelsson, Aasa; Berglin, Niklas; Lindgren, Karin (STFI-Packforsk, Stockholm (Sweden))

    2008-07-01

    Today, modern science could make it possible to develop techniques for refining almost the whole wood-matter, pulp mill side streams and bark compounds into platform chemicals, electricity, high quality fuels and structured feed-stock for chemicals and materials. The major challenge is to convert the state of basic scientific knowledge into industrial practise. Our definition of an integrated biorefinery is: 'Full utilization of the incoming biomass and other raw materials for simultaneous and economically optimized production of fibres, chemicals and energy'. Examples of products from a pulp mill biorefinery are: Chemicals and Materials (Phenols, adhesives, carbon fibres, activated carbon, binders, barriers, adhesives, antioxidants, surfactants, chelants, solvents, adhesives surfactants, descaling agents, specialty polymers, pharmaceuticals, nutraceuticals, cosmetics etc., Biofuels (pellets, lignin fuel, methanol, DME, ethanol etc), Electricity (BLGCC, condensing power etc.). The new or increased amounts of traditional products can be made from internal and/or external biomass. Three different levels can be identified: A high degree of energy saving in future mills, especially chemical pulp mills, will lead to large amounts of excess internal biomass which can be transferred to products mentioned above, Components in e.g. the black liquor, forest residues and bark can be upgraded to more valuable ones and the energy balance of the mill is kept through fuel import, wholly or partly depending on the level of mill energy efficiency. This imported fuel can be biomass or other types. External (imported) biomass (in some cases together with excess internal biomass) can be upgraded using synergy effects of docking this upgrading to a pulp mill. Electricity has been included as one of the possible biorefinery products. The electricity production in a mill can be increased in several ways which cannot be directly considered as biorefineries, e.g. recovery boiler

  2. Integrating Reflexivity in Livelihoods Research

    DEFF Research Database (Denmark)

    Prowse, Martin

    2010-01-01

    Much poverty and development research is not explicit about its methodology or philosophical foundations. Based on the extended case method of Burawoy and the epistemological standpoint of critical realism, this paper discusses a methodological approach for reflexive inductive livelihoods research...... that overcomes the unproductive social science dualism of positivism and social constructivism. The approach is linked to a conceptual framework and a menu of research methods that can be sequenced and iterated in light of research questions....

  3. Strategic Integration: The Practical Politics of Integrated Research in Context

    Directory of Open Access Journals (Sweden)

    Lorrae van Kerkhoff

    2005-01-01

    Full Text Available Designing an integrative research program requires that research leaders negotiate a balance between the scientific interest of research and the practical interests of non-scientific partners. This paper examines the ways integrated research is formally categorised, and analyses the tangible expressions of the practical politics involved in reconciling scientific and practical interests. Drawing on a comparative study of two Australian Cooperative Research Centres, I argue that categories used by the research leaders to describe the research programs embody three different strategies for structuring the relationships between researchers and their partners. These include matching research program categories to partners’ implementation program categories, reproducing existing integrative partnership models, and filling gaps in understanding with new technical approaches. These strategies offer different advantages and disadvantages. The cases suggest that the integrative approach favoured by each Centre depended on issues such as the geographic scope of policy arenas, sources of scientific credibility, and the political risks facing partners. The practical politics of research organisation offers a new lens for understanding both the practice and theory of integrated research.

  4. Multitasking mesoporous nanomaterials for biorefinery applications

    Energy Technology Data Exchange (ETDEWEB)

    Kandel, Kapil [Iowa State Univ., Ames, IA (United States)

    2013-01-01

    in microalgae biorefinery. Two different integrated biorefinery systems are highlighted. (i) OM-MSNs are used to harvest microalgae and selectively sequester free fatty acids (FFAs). (ii) OM-MSNs are shown to selectively sequester FFAs and convert them into diesel-range liquid hydrocarbon fuels. A similar MSN supported metal nanoparticle catalyst is demonstrated to transform FFAs into green diesel with even greater activity and selectivity. The incorporation of a different organic functional group into MSN provides a selective adsorbent for separation and purification of α-tocopherol from microalgae oil. The functional group with electron deficient aromatic rings demonstrated high sequestration capacity and selectivity of {alpha}-tocopherol.

  5. Biological processes for advancing lignocellulosic waste biorefinery by advocating circular economy.

    Science.gov (United States)

    Liguori, Rossana; Faraco, Vincenza

    2016-09-01

    The actualization of a circular economy through the use of lignocellulosic wastes as renewable resources can lead to reduce the dependence from fossil-based resources and contribute to a sustainable waste management. The integrated biorefineries, exploiting the overall lignocellulosic waste components to generate fuels, chemicals and energy, are the pillar of the circular economy. The biological treatment is receiving great attention for the biorefinery development since it is considered an eco-friendly alternative to the physico-chemical strategies to increase the biobased product recovery from wastes and improve saccharification and fermentation yields. This paper reviews the last advances in the biological treatments aimed at upgrading lignocellulosic wastes, implementing the biorefinery concept and advocating circular economy. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Modelling of the biorefinery scenarios - Bioscen

    Energy Technology Data Exchange (ETDEWEB)

    Pitkanen, J.-P. [VTT Technical Research Centre of Finland, Espoo (Finland)], email: juha-pekka.pitkanen@vtt.fi

    2012-07-01

    The purpose of the BioScen project was to develop quantitative modelling approaches for the future biomass based processes producing fuels and chemicals. The aim of the project was in developing methods to estimate the necessary material properties for phase and reaction equilibria, for the calculation of unit processes and their integration to biorefining production plant simulations. Additional focus was laid on model optimisation and product life cycle analysis. As the biorefining technologies possess an extensive range from thermal pyrolysis to biochemical processing at ambient temperatures, a most generic thermodynamically based approach was selected to enable usage of the methods to the wide variety of possible applications. The methods were then applied to a number of case studies including modelling of flash condensation of pyrolysis oil, hydrolysis of cellulosic biomass and its product recovery and the subsequent fermentation processes for bioethanol and biobutanol, for which also a comparative life cycle analysis was performed. Flowsheet process simulation was applied to a conceptual wood bark biorefinery. Metamodelling techniques were used for both model and parameter optimisation, including their sensitivity analysis.

  7. Containment integrity research program plan

    International Nuclear Information System (INIS)

    1987-08-01

    This report presents a plan for research on the question of containment performance in postulated severe accident scenarios. It focuses on the research being performed by the Structural and Seismic Engineering Branch, Division of Engineering, Office of Nuclear Regulatory Research. Summaries of the plans for this work have previously been published in the ''Nuclear Power Plant Severe Accident Research Plan'' (NUREG-0900). This report provides an update to reflect current status. This plan provides a summary of results to date as well as an outline of planned activities and milestones to the contemplated completion of the program in FY 1989

  8. Toward a common classification approach for biorefinery systems

    NARCIS (Netherlands)

    Cherubini, F.; Jungmeier, G.; Wellisch, M.; Wilke, T.; Skiadas, I.; Ree, van R.; Jong, de E.

    2009-01-01

    This paper deals with a biorefinery classification approach developed within International Energy Agency (IEA) Bioenergy Task 42. Since production of transportation biofuels is seen as the driving force for future biorefinery developments, a selection of the most interesting transportation biofuels

  9. Can organic crops increase the economic potential for biorefineries?

    OpenAIRE

    Gylling, Morten; Jakobsen, Anders B.

    2017-01-01

    With the current cost and price relations, the profitability of biorefineries is still challenged. The use of organic crops, such as grass, in biorefineries can increase the profitability because organic products can be sold at higher prices.

  10. Alternative use of grassland biomass for biorefinery in Ireland: a scoping study

    NARCIS (Netherlands)

    O'Keeffe, S.

    2010-01-01

    The need to reduce greenhouse gas emissions and dependency on fossil fuels has been one of the main driving forces to use renewable resources for energy and chemicals. The integrated use of grassland biomass for the production of chemicals and energy, also known as Green Biorefinery (GBR), has

  11. Research System Integration Laboratory (SIL)

    Data.gov (United States)

    Federal Laboratory Consortium — The VEA Research SIL (VRS) is essential to the success of the TARDEC 30-Year Strategy. The vast majority of the TARDEC Capability Sets face challenging electronics...

  12. Integrated 1st and 2nd generation sugarcane bio-refinery for jet fuel production in Brazil: Techno-economic and greenhouse gas emissions assessment

    DEFF Research Database (Denmark)

    Santos, Catarina I.; Silva, Constança C.; Mussatto, Solange I.

    2017-01-01

    ). Although, the MJSP calculated for all scenarios are higher than those of the fossil jet fuel reference, the significant potential for environmental impacts reduction (in terms of GHG emissions and primary energy use) are encouraging for further research in costs reduction and technology development....... (i.e. co-generation). From the combination of these key features, 81 scenarios are selected and compared. Furthermore, three potential technological improvements were analysed for selected scenarios: i) recovery of acetic acid and furfural (for cases with bagasse pretreatment); ii) production.......e. greenhouse gas (GHG) emissions and non-renewable energy use (NREU)). Among the scenarios considering biomass pretreatment, the lower MJSP are obtained when 1G/2G sugars are upgraded via ethanol fermentation (ETJ) (i.e. SO2 steam explosion: 3409 US $.ton−1, and wet oxidation: 3230 US $.ton−1). Additional...

  13. Estimating Hydrogen Production Potential in Biorefineries Using Microbial Electrolysis Cell Technology

    Energy Technology Data Exchange (ETDEWEB)

    Borole, Abhijeet P [ORNL; Mielenz, Jonathan R [ORNL

    2011-01-01

    Microbial electrolysis cells (MECs) are devices that use a hybrid biocatalysis-electrolysis process for production of hydrogen from organic matter. Future biofuel and bioproducts industries are expected to generate significant volumes of waste streams containing easily degradable organic matter. The emerging MEC technology has potential to derive added- value from these waste streams via production of hydrogen. Biorefinery process streams, particularly the stillage or distillation bottoms contain underutilized sugars as well as fermentation and pretreatment byproducts. In a lignocellulosic biorefinery designed for producing 70 million gallons of ethanol per year, up to 7200 m3/hr of hydrogen can be generated. The hydrogen can either be used as an energy source or a chemical reagent for upgrading and other reactions. The energy content of the hydrogen generated is sufficient to meet 57% of the distillation energy needs. We also report on the potential for hydrogen production in existing corn mills and sugar-based biorefineries. Removal of the organics from stillage has potential to facilitate water recycle. Pretreatment and fermentation byproducts generated in lignocellulosic biorefinery processes can accumulate to highly inhibitory levels in the process streams, if water is recycled. The byproducts of concern including sugar- and lignin- degradation products such as furans and phenolics can also be converted to hydrogen in MECs. We evaluate hydrogen production from various inhibitory byproducts generated during pretreatment of various types of biomass. Finally, the research needs for development of the MEC technology and aspects particularly relevant to the biorefineries are discussed.

  14. Biorefinery systems – potential contributors to sustainable innovation

    NARCIS (Netherlands)

    Wellisch, M.; Jungmeier, G.; Karbowski, A.; Patel, M.K.; Rogulska, M.

    2010-01-01

    Sustainable biorefineries have a critical role to play in our common future. The need to provide more goods using renewable resources, combined with advances in science and technology, has provided a receptive environment for biorefinery systems development. Biorefineries offer the promise of using

  15. Biorefineries – factories of the future

    Directory of Open Access Journals (Sweden)

    Kołtuniewicz Andrzej B.

    2016-03-01

    Full Text Available Efforts were made to demonstrate that in biorefineries it is possible to manufacture all the commodities required for maintaining human civilisation on the current level. Biorefineries are based on processing biomass resulting from photosynthesis. From sugars, oils and proteins, a variety of food, feed, nutrients, pharmaceuticals, polymers, chemicals and fuels can further be produced. Production in biorefineries must be based on a few rules to fulfil sustainable development: all raw materials are derived from biomass, all products are biodegradable and production methods are in accordance with the principles of Green Chemistry and Clean Technology. The paper presents a summary of state-of-the-art concerning biorefineries, production methods and product range of leading companies in the world that are already implemented. Potential risks caused by the development of biorefineries, such as: insecurities of food and feed production, uncontrolled changes in global production profiles, monocultures, eutrophication, etc., were also highlighted in this paper. It was stressed that the sustainable development is not only an alternative point of view but is our condition to survive.

  16. Chemistry in forest biorefineries 2 - BIORAFF 2

    Energy Technology Data Exchange (ETDEWEB)

    Hupa, M. (Aabo Akademi, Process Chemistry Centre, Turku (Finland)), email: mhupa@abo.fi; Auer, M. (Aabo Akademi, Process Chemistry Centre, Turku (Finland); VTT Technical Research Centre of Finland, Espoo (Finland)), email: mauer@abo.fi

    2009-10-15

    The biorefinery concept may be compared to an oil refinery and petrochemical plant, where fuels and numerous intermediates are produced for further processing into high-value and speciality materials. In biorefineries, the raw material instead of mineral oil is bio-based materials. Biorefinery development at the US and European level mostly covers the use of annual crops and other bio-based materials. However, in this project focus is on non-food materials primarily in industrial pulp and paper processes and this project is limited to forest-based biorefineries. The aim of the project is also to preserve the molecular structures created by the nature as much as possible, to explore new separation and purification methods and look at new applications in the areas such as: functional food, nutritional additives, functional additives in paper making, antioxidants, new biobased materials and biobased energy. As the area, in spite of efforts to limit it, is very large, we have selected to focus on a limited number of concretized projects, which to our knowledge are complementary with other efforts for promoting biorefinery concepts. (orig.)

  17. Integration of operational research and environmental management

    NARCIS (Netherlands)

    Bloemhof - Ruwaard, J.M.

    1996-01-01


    The subject of this thesis is the integration of Operational Research and Environmental Management. Both sciences play an important role in the research of environmental issues. Part I describes a framework for the interactions between Operational Research and Environmental Management.

  18. Modelling, synthesis and analysis of biorefinery networks

    DEFF Research Database (Denmark)

    Bertran, Maria-Ona

    for the conversion of biomass into chemicals, fuels and energy, because they have the potential to maximize biomass value while reducing emissions. The design of biorefinery networks is a complex decisionmaking problem that involves the selection of feedstocks, processing technologies, products, geographical...... locations, and operating conditions, among others. Unlike petroleumbased processing networks, biorefineries rely on feedstocks that are nonhomogeneous across geographical areas in terms of their availability, type and properties. For this reason, the performance of biorefinery networks depends...... of reactions to convert available biomassbased feedstocks into desired products, the selection of processing routes and technologies from a large set of alternatives, or the generation of hybrid technologies through process intensification. Systematic process synthesis and design methods have been developed...

  19. Supporting Theory Building in Integrated Services Research

    Science.gov (United States)

    Robinson, Mark; Atkinson, Mary; Downing, Dick

    2008-01-01

    This literature review was commissioned by the National Foundation for Educational Research (NFER) to draw together current and recent studies of integrated working, in order to build an overview of the theories and models of such working. The review is important for current work on evaluating the early impact of integrated children's services and…

  20. Integration: An Agenda for Developmental Research.

    Science.gov (United States)

    Scholnick, Ellin Kofsky

    2001-01-01

    Finds Bloom and Tinker's description and measurement of active, integrated, and situated children to be a credible scientifically rigorous paradigm for language acquisition research. Highlights their use of the naturalistic, observational method to understand the changing patterns of integration and use of multifaceted abilities in child language…

  1. Promoting research integrity in the geosciences

    Science.gov (United States)

    Mayer, Tony

    2015-04-01

    Conducting research in a responsible manner in compliance with codes of research integrity is essential. The geosciences, as with all other areas of research endeavour, has its fair share of misconduct cases and causes celebres. As research becomes more global, more collaborative and more cross-disciplinary, the need for all concerned to work to the same high standards becomes imperative. Modern technology makes it far easier to 'cut and paste', to use Photoshop to manipulate imagery to falsify results at the same time as making research easier and more meaningful. So we need to promote the highest standards of research integrity and the responsible conduct of research. While ultimately, responsibility for misconduct rests with the individual, institutions and the academic research system have to take steps to alleviate the pressure on researchers and promote good practice through training programmes and mentoring. The role of the World Conferences on Research Integrity in promoting the importance of research integrity and statements about good practice will be presented and the need for training and mentoring programmes will be discussed

  2. Integrated Food studies education and research:

    DEFF Research Database (Denmark)

    Hansen, Mette Weinreich; Hansen, Stine Rosenlund

    2018-01-01

    The research group Foodscapes Innovation and Networks has addressed integrated food studies issues in re-search and education since 2010. Based on experiences in the group, this paper aims at discussing the chal-lenges, learning outcomes and potentials for pushing an integrated thinking into rese......The research group Foodscapes Innovation and Networks has addressed integrated food studies issues in re-search and education since 2010. Based on experiences in the group, this paper aims at discussing the chal-lenges, learning outcomes and potentials for pushing an integrated thinking...... into research and education. It also addresses the challenges in integration when the methodological approaches and theoretical frameworks chosen are ontologically and epistemologically different. A discussion of the limitations of integration is thus also part of the paper. The conceptual framework...... of ontonorms (Mol, 2013) is suggested as a common point of departure for a further development of integration. This is suggested relevant due to the fact that it forces different traditions to reflect their own value-related basis and discuss implications of this approach in a broader sense. The common values...

  3. The European structural integrity research programme

    International Nuclear Information System (INIS)

    Townley, C.H.A.; Acker, D.; Laue, H.

    1990-01-01

    A thermal hydraulics evaluation of the European Fast Reactor (EFR) design followed by structural analysis is presented in this article to assess the structural integrity research programme to date. Improved design methods are being achieved as a result of the structural integrity programme for the EFR. Excellent collaboration between the nationally based research organizations and the design and construction companies has been important in achieving these improvements. (UK)

  4. Data integration in biological research: an overview.

    Science.gov (United States)

    Lapatas, Vasileios; Stefanidakis, Michalis; Jimenez, Rafael C; Via, Allegra; Schneider, Maria Victoria

    2015-12-01

    Data sharing, integration and annotation are essential to ensure the reproducibility of the analysis and interpretation of the experimental findings. Often these activities are perceived as a role that bioinformaticians and computer scientists have to take with no or little input from the experimental biologist. On the contrary, biological researchers, being the producers and often the end users of such data, have a big role in enabling biological data integration. The quality and usefulness of data integration depend on the existence and adoption of standards, shared formats, and mechanisms that are suitable for biological researchers to submit and annotate the data, so it can be easily searchable, conveniently linked and consequently used for further biological analysis and discovery. Here, we provide background on what is data integration from a computational science point of view, how it has been applied to biological research, which key aspects contributed to its success and future directions.

  5. Forest biorefinery: Potential of poplar phytochemicals as value-added co-products.

    Science.gov (United States)

    Devappa, Rakshit K; Rakshit, Sudip K; Dekker, Robert F H

    2015-11-01

    The global forestry industry after experiencing a market downturn during the past decade has now aimed its vision towards the integrated biorefinery. New business models and strategies are constantly being explored to re-invent the global wood and pulp/paper industry through sustainable resource exploitation. The goal is to produce diversified, innovative and revenue generating product lines using on-site bioresources (wood and tree residues). The most popular product lines are generally produced from wood fibers (biofuels, pulp/paper, biomaterials, and bio/chemicals). However, the bark and other tree residues like foliage that constitute forest wastes, still remain largely an underexploited resource from which extractives and phytochemicals can be harnessed as by-products (biopharmaceuticals, food additives and nutraceuticals, biopesticides, cosmetics). Commercially, Populus (poplar) tree species including hybrid varieties are cultivated as a fast growing bioenergy crop, but can also be utilized to produce bio-based chemicals. This review identifies and underlines the potential of natural products (phytochemicals) from Populus species that could lead to new business ventures in biorefineries and contribute to the bioeconomy. In brief, this review highlights the importance of by-products/co-products in forest industries, methods that can be employed to extract and purify poplar phytochemicals, the potential pharmaceutical and other uses of >160 phytochemicals identified from poplar species - their chemical structures, properties and bioactivities, the challenges and limitations of utilizing poplar phytochemicals, and potential commercial opportunities. Finally, the overall discussion and conclusion are made considering the recent biotechnological advances in phytochemical research to indicate the areas for future commercial applications from poplar tree species. Crown Copyright © 2015. Published by Elsevier Inc. All rights reserved.

  6. Impact of trucking network flow on preferred biorefinery locations in the southern United States

    Science.gov (United States)

    Timothy M. Young; Lee D. Han; James H. Perdue; Stephanie R. Hargrove; Frank M. Guess; Xia Huang; Chung-Hao Chen

    2017-01-01

    The impact of the trucking transportation network flow was modeled for the southern United States. The study addresses a gap in existing research by applying a Bayesian logistic regression and Geographic Information System (GIS) geospatial analysis to predict biorefinery site locations. A one-way trucking cost assuming a 128.8 km (80-mile) haul distance was estimated...

  7. Energy Opportunities from Lignocellulosic Biomass for a Biorefinery Case Study

    Directory of Open Access Journals (Sweden)

    Franco Cotana

    2016-09-01

    Full Text Available This work presents some energy considerations concerning a biorefinery case study that has been carried out by the CRB/CIRIAF of the University of Perugia. The biorefinery is the case study of the BIT3G project, a national funded research project, and it uses the lignocellulosic biomass that is available in the territory as input materials for biochemical purposes, such as cardoon and carthamus. The whole plant is composed of several sections: the cardoon and carthamus seed milling, the oil refinement facilities, and the production section of some high quality biochemicals, i.e., bio-oils and fatty acids. The main goal of the research is to demonstrate energy autonomy of the latter section of the biorefinery, while only recovering energy from the residues resulting from the collection of the biomass. To this aim, this work presents the quantification of the energy requirements to be supplied to the considered biorefinery section, the mass flow, and the energy and chemical characterization of the biomass. Afterwards, some sustainability strategies have been qualitatively investigated in order to identify the best one to be used in this case study; the combined heat and power (CHP technology. Two scenarios have been defined and presented: the first with 6 MWt thermal input and 1.2 MWe electrical power as an output and the second with 9 MWt thermal input and 1.8 MWe electrical power as an output. The first scenario showed that 11,000 tons of residual biomass could ensure the annual production of about 34,000 MWht, equal to about the 72% of the requirements, and about 9600 MWhe, equal to approximately 60% of the electricity demand. The second scenario showed that 18,000 tons of the residual biomass could ensure the total annual production of about 56,000 MWht, corresponding to more than 100% of the requirements, and about 14,400 MWhe, equal to approximately 90% of the electricity demand. In addition, the CO2 emissions from the energy valorization

  8. Lignin pyrolysis for profitable lignocellulosic biorefineries

    NARCIS (Netherlands)

    Wild, de P.J.; Gosselink, R.J.A.; Huijgen, W.J.J.

    2014-01-01

    Bio-based industries (pulp and paper and biorefineries) produce > 50 Mt/yr of lignin that results from fractionation of lignocellulosic biomass. Lignin is world's second biopolymer and a major potential source for production of performance materials and aromatic chemicals. Lignin valorization is

  9. Location-dependent optimal biorefinery synthesis

    DEFF Research Database (Denmark)

    Bertran, Maria-Ona; Woodley, John M.; Gani, Rafiqul

    2017-01-01

    In this paper, we present an extended framework for synthesis of biorefinery networks. The extension of the framework responds to the needs of: automatically generating problem-specific superstructures from an in-house database in an efficient and reliable way, as well as obtaining and analysing...

  10. The biorefinery concept: Using biomass instead of oil for producing energy and chemicals

    International Nuclear Information System (INIS)

    Cherubini, Francesco

    2010-01-01

    A great fraction of worldwide energy carriers and material products come from fossil fuel refinery. Because of the on-going price increase of fossil resources, their uncertain availability, and their environmental concerns, the feasibility of oil exploitation is predicted to decrease in the near future. Therefore, alternative solutions able to mitigate climate change and reduce the consumption of fossil fuels should be promoted. The replacement of oil with biomass as raw material for fuel and chemical production is an interesting option and is the driving force for the development of biorefinery complexes. In biorefinery, almost all the types of biomass feedstocks can be converted to different classes of biofuels and biochemicals through jointly applied conversion technologies. This paper provides a description of the emerging biorefinery concept, in comparison with the current oil refinery. The focus is on the state of the art in biofuel and biochemical production, as well as discussion of the most important biomass feedstocks, conversion technologies and final products. Through the integration of green chemistry into biorefineries, and the use of low environmental impact technologies, future sustainable production chains of biofuels and high value chemicals from biomass can be established. The aim of this bio-industry is to be competitive in the market and lead to the progressive replacement of oil refinery products. (author)

  11. Carbon dioxide utilization in a microalga-based biorefinery: Efficiency of carbon removal and economic performance under carbon taxation.

    Science.gov (United States)

    Wiesberg, Igor Lapenda; Brigagão, George Victor; de Medeiros, José Luiz; de Queiroz Fernandes Araújo, Ofélia

    2017-12-01

    Coal-fired power plants are major stationary sources of carbon dioxide and environmental constraints demand technologies for abatement. Although Carbon Capture and Storage is the most mature route, it poses severe economic penalty to power generation. Alternatively, this penalty is potentially reduced by Carbon Capture and Utilization, which converts carbon dioxide to valuable products, monetizing it. This work evaluates a route consisting of carbon dioxide bio-capture by Chlorella pyrenoidosa and use of the resulting biomass as feedstock to a microalgae-based biorefinery; Carbon Capture and Storage route is evaluated as a reference technology. The integrated arrangement comprises: (a) carbon dioxide biocapture in a photobioreactor, (b) oil extraction from part of the produced biomass, (b) gasification of remaining biomass to obtain bio-syngas, and (c) conversion of bio-syngas to methanol. Calculation of capital and operational expenditures are estimated based on mass and energy balances obtained by process simulation for both routes (Carbon Capture and Storage and the biorefinery). Capital expenditure for the biorefinery is higher by a factor of 6.7, while operational expenditure is lower by a factor of 0.45 and revenues occur only for this route, with a ratio revenue/operational expenditure of 1.6. The photobioreactor is responsible for one fifth of the biorefinery capital expenditure, with footprint of about 1000 ha, posing the most significant barrier for technical and economic feasibility of the proposed biorefinery. The Biorefinery and Carbon Capture and Storage routes show carbon dioxide capture efficiency of 73% and 48%, respectively, with capture cost of 139$/t and 304$/t. Additionally, the biorefinery has superior performance in all evaluated metrics of environmental impacts. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Data-Intensive Science and Research Integrity.

    Science.gov (United States)

    Resnik, David B; Elliott, Kevin C; Soranno, Patricia A; Smith, Elise M

    2017-01-01

    In this commentary, we consider questions related to research integrity in data-intensive science and argue that there is no need to create a distinct category of misconduct that applies to deception related to processing, analyzing, or interpreting data. The best way to promote integrity in data-intensive science is to maintain a firm commitment to epistemological and ethical values, such as honesty, openness, transparency, and objectivity, which apply to all types of research, and to promote education, policy development, and scholarly debate concerning appropriate uses of statistics.

  13. UTILIZATION OF AGROINDUSTRIALES RESIDUES AS BIOFUELS AND BIOREFINERY

    Directory of Open Access Journals (Sweden)

    Deyanira Muñoz-Muñoz

    2014-12-01

    Full Text Available The use of residues generated in the process agro-industrials are interest worldwide. At present, research is this in lignocellulosic biomass for energy, fuels, chemicals and biomaterials through clean technologies and closed systems that conserve the environment. In this research, based on the characteristics of the typical agro-industrial residues of Cauca Department, sugarcane bagasse, sisal dust, cassava bran and the mixtures, was evaluated use as biorefinery. Were determined the thermal, physical chemical and morphologic properties in seven samples of residues, were performed exploratory tests, were determined pretreatments and applications and the possible use were identified. We conclude that the sample M6 with 9,93 % moisture, 4,12% ash, 43,97% carbon, 5,86% hydrogen, 0,43% nitrogen, 15 MJ/kg of lower heating value and 22,25%of cellulose, 9,30% of hemicellulose and 4,56% lignin, presents characteristics appropriate to be used in furnaces and boilers less power for the rural sector by the amount of ash, which keeps the low heating power stable and reduces the emission of particulate matter. For the thermal, physical, chemical and morphological characteristics, all the samples of M1 to M7, they can be hydrolyzed, densified and taken advantage like biofuel and / or biorefinery

  14. Rethinking global health research: towards integrative expertise

    Directory of Open Access Journals (Sweden)

    MacLachlan Malcolm

    2009-07-01

    Full Text Available Abstract The Bamako Call for Action on Research for Health stresses the importance of inter-disciplinary, inter-ministerial and inter-sectoral working. This challenges much of our current research and postgraduate research training in health, which mostly seeks to produce narrowly focused content specialists. We now need to compliment this type of research and research training, by offering alternative pathways that seek to create expertise, not only in specific narrow content areas, but also in the process and context of research, as well as in the interaction of these different facets of knowledge. Such an approach, developing 'integrative expertise', could greatly facilitate better research utilisation, helping policy makers and practitioners work through more evidence-based practice and across traditional research boundaries.

  15. The epistemic integrity of scientific research.

    Science.gov (United States)

    De Winter, Jan; Kosolosky, Laszlo

    2013-09-01

    We live in a world in which scientific expertise and its epistemic authority become more important. On the other hand, the financial interests in research, which could potentially corrupt science, are increasing. Due to these two tendencies, a concern for the integrity of scientific research becomes increasingly vital. This concern is, however, hollow if we do not have a clear account of research integrity. Therefore, it is important that we explicate this concept. Following Rudolf Carnap's characterization of the task of explication, this means that we should develop a concept that is (1) similar to our common sense notion of research integrity, (2) exact, (3) fruitful, and (4) as simple as possible. Since existing concepts do not meet these four requirements, we develop a new concept in this article. We describe a concept of epistemic integrity that is based on the property of deceptiveness, and argue that this concept does meet Carnap's four requirements of explication. To illustrate and support our claims we use several examples from scientific practice, mainly from biomedical research.

  16. Integrating meteorology into research on migration.

    Science.gov (United States)

    Shamoun-Baranes, Judy; Bouten, Willem; van Loon, E Emiel

    2010-09-01

    Atmospheric dynamics strongly influence the migration of flying organisms. They affect, among others, the onset, duration and cost of migration, migratory routes, stop-over decisions, and flight speeds en-route. Animals move through a heterogeneous environment and have to react to atmospheric dynamics at different spatial and temporal scales. Integrating meteorology into research on migration is not only challenging but it is also important, especially when trying to understand the variability of the various aspects of migratory behavior observed in nature. In this article, we give an overview of some different modeling approaches and we show how these have been incorporated into migration research. We provide a more detailed description of the development and application of two dynamic, individual-based models, one for waders and one for soaring migrants, as examples of how and why to integrate meteorology into research on migration. We use these models to help understand underlying mechanisms of individual response to atmospheric conditions en-route and to explain emergent patterns. This type of models can be used to study the impact of variability in atmospheric dynamics on migration along a migratory trajectory, between seasons and between years. We conclude by providing some basic guidelines to help researchers towards finding the right modeling approach and the meteorological data needed to integrate meteorology into their own research. © The Author 2010. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved.

  17. Fostering Collaborations towards Integrative Research Development

    Directory of Open Access Journals (Sweden)

    Leonie Valentine

    2013-05-01

    Full Text Available The complex problems associated with global change processes calls for close collaboration between science disciplines to create new, integrated knowledge. In the wake of global change processes, forests and other natural environments have been rapidly changing, highlighting the need for collaboration and integrative research development. Few tools are available to explore the potential for collaborations in research ventures that are just starting up. This study presents a useful approach for exploring and fostering collaborations between academics working in research teams and organizations comprising multiple science disciplines (i.e., multi-disciplinary. The research aim was to reveal potential barriers, common ground, and research strengths between academics working in a new centre focused on forest and climate change research. This aim was based on the premise that raising awareness and working with this acquired knowledge fosters collaborations and integrative research development. An email survey was deployed amongst the academics to obtain: (i their understanding of common themes (e.g., climate change, scale of investigation, woodland/forest health/decline; (ii descriptions of the spatial and temporal scales of their research; and (iii their approach and perceived contributions to climate change research. These data were analysed using a semi-quantitative content analysis approach. We found that the main potential barriers were likely to be related to differences in understanding of the common research themes, whilst similarities and disciplinary strengths provided critical elements to foster collaborations. These findings were presented and discussed amongst the centre academics to raise awareness and create a dialogue around these issues. This process resulted in the development of four additional research projects involving multiple disciplines. The approach used in this study provides a useful methodology of broader benefit to

  18. An Integrated Extravehicular Activity Research Plan

    Science.gov (United States)

    Abercromby, Andrew F. J.; Ross, Amy J.; Cupples, J. Scott

    2016-01-01

    Multiple organizations within NASA and outside of NASA fund and participate in research related to extravehicular activity (EVA). In October 2015, representatives of the EVA Office, the Crew and Thermal Systems Division (CTSD), and the Human Research Program (HRP) at NASA Johnson Space Center agreed on a formal framework to improve multi-year coordination and collaboration in EVA research. At the core of the framework is an Integrated EVA Research Plan and a process by which it will be annually reviewed and updated. The over-arching objective of the collaborative framework is to conduct multi-disciplinary cost-effective research that will enable humans to perform EVAs safely, effectively, comfortably, and efficiently, as needed to enable and enhance human space exploration missions. Research activities must be defined, prioritized, planned and executed to comprehensively address the right questions, avoid duplication, leverage other complementary activities where possible, and ultimately provide actionable evidence-based results in time to inform subsequent tests, developments and/or research activities. Representation of all appropriate stakeholders in the definition, prioritization, planning and execution of research activities is essential to accomplishing the over-arching objective. A formal review of the Integrated EVA Research Plan will be conducted annually. External peer review of all HRP EVA research activities including compilation and review of published literature in the EVA Evidence Book is already performed annually. Coordination with stakeholders outside of the EVA Office, CTSD, and HRP is already in effect on a study-by-study basis; closer coordination on multi-year planning with other EVA stakeholders including academia is being actively pursued. Details of the current Integrated EVA Research Plan are presented including description of ongoing and planned research activities in the areas of: Benchmarking; Anthropometry and Suit Fit; Sensors; Human

  19. The production of pigments and hydrogen through a Spirogyra sp. biorefinery

    International Nuclear Information System (INIS)

    Pacheco, R.; Ferreira, A.F.; Pinto, T.; Nobre, B.P.; Loureiro, D.; Moura, P.; Gouveia, L.; Silva, C.M.

    2015-01-01

    Highlights: • Sugar content of microalgae must increase to increase H 2 yield. • Electrocoagulation and solar dryer reduce 90% the harvesting-drying energy demand. • Paddle wheels contribute 5% to culture energy demand when using ideal 0.1 kW/m 2 . • Pigment extraction increases 2 times the biorefinery economic benefits. • Pigment energy demand account for 62% and must be reduced significantly. - Abstract: This paper discusses the overall energy consumption and greenhouse gas emissions when extracting pigments and producing hydrogen from Spirogyra sp. microalga biomass. The energy evaluation from the biomass leftovers was also included in this work. The influence of the functional unit and different allocation criteria on the biorefinery assessments is also shown. The study consists of laboratory tests showing Spirogyra sp. growth, harvesting, drying, pigment extraction and fermentation by Clostridium butyricum. Electrocoagulation and solar drying were tested and compared to conventional centrifugation and electrical dewatering in terms of their energy consumption for harvesting and dewatering, respectively. To discuss the biorefinery viability, the pigments and biohydrogen (bioH 2 ) retail costs are considered against operational costs according to electricity needs. The low yield of biochemical hydrogen and the high energy requirements for the pigment extraction were identified as main topics for further research. This research hopefully contributes to highlight the importance of energy and emission balances in order to decide on feasibility of the biorefinery

  20. Undergraduate courses with an integral research year

    International Nuclear Information System (INIS)

    Clough, A S; Regan, P H

    2003-01-01

    We present the details of the four year MPhys undergraduate degree provided by the University of Surrey. Integral to this course is a full year spent on a research placement, which in most cases takes place external to the university at a North American or European research centre. This paper outlines the basic rationale underlying the course and, by including a number of research student profiles, we discuss the triple benefits of this course for the students, the University of Surrey and the host institutions where the students spend their research year

  1. Commercializing Biorefinery Technology: A Case for the Multi-Product Pathway to a Viable Biorefinery

    Directory of Open Access Journals (Sweden)

    Shijie Liu

    2011-11-01

    Full Text Available While there may be many reasons why very interesting science ideas never reach commercial practice, one of the more prevalent is that the reaction or process, which is scientifically possible, cannot be made efficient enough to achieve economic viability. One pathway to economic viability for many business sectors is the multi-product portfolio. Research, development, and deployment of viable biorefinery technology must meld sound science with engineering and business economics. It is virtually axiomatic that increased value can be generated by isolating relatively pure substances from heterogeneous raw materials. Woody biomass is a heterogeneous raw material consisting of the major structural components, cellulose, lignin, and hemicelluloses, as well as minor components, such as extractives and ash. Cellulose is a linear homopolymer of D-glucopyrano-units with β-D(1®4 connections and is the wood component most resistant to chemical and biological degradation. Lignin is a macromolecule of phenylpropanoid units, second to cellulose in bio-resistance, and is the key component that is sought for removal from woody biomass in chemical pulping. Hemicelluloses are a collection of heteropolysaccharides, comprised mainly of 5- and 6-carbon sugars. Extractives, some of which have high commercial value, are a collection of low molecular weight organic and inorganic woody materials that can be removed, to some extent, under mild conditions. Applied Biorefinery Sciences, LLC (a private, New York, USA based company is commercializing a value-optimization pathway (the ABS Process™ for generating a multi-product portfolio by isolating and recovering homogeneous substances from each of the above mentioned major and minor woody biomass components. The ABS Process™ incorporates the patent pending, core biorefinery technology, “hot water extraction”, as developed at the State University of New York College of Environmental Science and Forestry (SUNY

  2. Integrated Pest Management Research Symposium: The Proceedings

    Science.gov (United States)

    Susan J. Branham; Robert C. Thatcher; [Editors

    1985-01-01

    Thirty-seven papers are presented that summarize the findings from research and development work conducted as a part of the Integrated Pest Management RD&A Program for Bark Beetles of Southern Pines during the 5-year period 1980-85. Presentations cover the areas of sampling and impact assessment, bark beetle biology and ecology, host susceptibility, host/pest...

  3. Integrating Research Competencies in Massage Therapy Education.

    Science.gov (United States)

    Hymel, Glenn M.

    The massage therapy profession is currently engaged in a competency-based education movement that includes an emphasis on promoting massage therapy research competencies (MTRCs). A systems-based model for integrating MTRCs into massage therapy education was therefore proposed. The model and an accompanying checklist describe an approach to…

  4. Valorization of cereal based biorefinery byproducts: reality and expectations.

    Science.gov (United States)

    Elmekawy, Ahmed; Diels, Ludo; De Wever, Heleen; Pant, Deepak

    2013-08-20

    The growth of the biobased economy will lead to an increase in new biorefinery activities. All biorefineries face the regular challenges of efficiently and economically treating their effluent to be compatible with local discharge requirements and to minimize net water consumption. The amount of wastes resulting from biorefineries industry is exponentially growing. The valorization of such wastes has drawn considerable attention with respect to resources with an observable economic and environmental concern. This has been a promising field which shows great prospective toward byproduct usage and increasing value obtained from the biorefinery. However, full-scale realization of biorefinery wastes valorization is not straightforward because several microbiological, technological and economic challenges need to be resolved. In this review we considered valorization options for cereals based biorefineries wastes while identifying their challenges and exploring the opportunities for future process.

  5. Leading with integrity: a qualitative research study.

    Science.gov (United States)

    Storr, Loma

    2004-01-01

    This research paper gives an account of a study into the relationship between leadership and integrity. There is a critical analysis of the current literature for effective, successful and ethical leadership particularly, integrity. The purpose and aim of this paper is to build on the current notions of leadership within the literature, debate contemporary approaches, focussing specifically on practices within the UK National Health Service in the early 21st century. This leads to a discussion of the literature on ethical leadership theory, which includes public service values, ethical relationships and leading with integrity. A small study was undertaken consisting of 18 interviews with leaders and managers within a District General HospitaL Using the Repertory Grid technique and analysis 15 themes emerged from the constructs elicited, which were compared to the literature for leadership and integrity and other studies. As well as finding areas of overlap, a number of additional constructs were elicited which suggested that effective leadership correlates with integrity and the presence of integrity will improve organisational effectiveness. The study identified that perceptions of leadership character and behaviour are used to judge the effectiveness and integrity of a leader. However, the ethical implications and consequences of leaders' scope of power and influence such as policy and strategy are somewhat neglected and lacking in debate. The findings suggest that leaders are not judged according to the ethical nature of decision making, and leading and managing complex change but that the importance of integrity and ethical leadership correlated with higher levels of hierarchical status and that it is assumed by virtue of status and success that leaders lead with integrity. Finally, the findings of this study seem to suggest that nurse leadership capability is developing as a consequence of recent national investment.

  6. The Civilisation Biorefinery - A Future Approach for Material and Energy Recovery from Regional Organic Waste

    International Nuclear Information System (INIS)

    Koerner, I.

    2010-01-01

    The future shortage of energy and raw materials as well as the problems on climate protection are challenges for which a solution is imperative. For efficient utilizing organic liquid and solid wastes which are generated in a city, a city itself could become a civilisation biorefinery. The output will be various energetic and material products, which can be used in the city or in the surrounding of the city. Depending on the nature of the various urban input materials, they need to be fed in to biorefineries adapted to the substrate type. The separate substrate-specific biorefineries may be at central or decentralised locations within the city. Moreover, since the residues from one system can be used in others as input, mutual networking is of importance. To facilitate efficient valorification, bioresources and the type of biorefinery need to be optimally matched. That also means that at the collection stage already, the material properties of the bioresource must be taken into account and where appropriate, new collection systems introduced, or consideration should be given to technical processes for separation of mixtures of materials. Extremely differing cascades will be appropriate for the various regional situations. For this reason, the evaluation of alternative schemes will be seen as very significant. Additional important points are the suitability of new measures or processes for integration into existing regional structures, as well as the logistics aspects, including the question of whether bioconversion processes should be conducted centrally or in decentralised locations. In Germany, considerable amounts of biowaste are available today and in the future which, until now, were almost entirely composted. The possibilities of anaerobic fermentation are gaining more and more in importance. Aerobic and anaerobic treatments of biowaste are more and more combined within the scope of a win-win situation. These technologies will be important parts of a

  7. CLARA: an integrated clinical research administration system

    Science.gov (United States)

    Bian, Jiang; Xie, Mengjun; Hogan, William; Hutchins, Laura; Topaloglu, Umit; Lane, Cheryl; Holland, Jennifer; Wells, Thomas

    2014-01-01

    Administration of human subject research is complex, involving not only the institutional review board but also many other regulatory and compliance entities within a research enterprise. Its efficiency has a direct and substantial impact on the conduct and management of clinical research. In this paper, we report on the Clinical Research Administration (CLARA) platform developed at the University of Arkansas for Medical Sciences. CLARA is a comprehensive web-based system that can streamline research administrative tasks such as submissions, reviews, and approval processes for both investigators and different review committees on a single integrated platform. CLARA not only helps investigators to meet regulatory requirements but also provides tools for managing other clinical research activities including budgeting, contracting, and participant schedule planning. PMID:24778201

  8. Human Research Program Integrated Research Plan. Revision A January 2009

    Science.gov (United States)

    2009-01-01

    The Integrated Research Plan (IRP) describes the portfolio of Human Research Program (HRP) research and technology tasks. The IRP is the HRP strategic and tactical plan for research necessary to meet HRP requirements. The need to produce an IRP is established in HRP-47052, Human Research Program - Program Plan, and is under configuration management control of the Human Research Program Control Board (HRPCB). Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) is essential to enabling extended periods of space exploration because it provides knowledge and tools to mitigate risks to human health and performance. Risks include physiological and behavioral effects from radiation and hypogravity environments, as well as unique challenges in medical support, human factors, and behavioral or psychological factors. The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies and tools to enable safe, reliable, and productive human space exploration. Without HRP results, NASA will face unknown and unacceptable risks for mission success and post-mission crew health. This Integrated Research Plan (IRP) describes HRP s approach and research activities that are intended to address the needs of human space exploration and serve HRP customers and how they are integrated to provide a risk mitigation tool. The scope of the IRP is limited to the activities that can be conducted with the resources available to the HRP; it does not contain activities that would be performed if additional resources were available. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration.

  9. Liquefaction of Biorefinery Lignin for Fuel Production

    DEFF Research Database (Denmark)

    Jensen, Anders

    at higher loadings. The effect of increased reaction time was found to be beneficial for oil yields but also caused an increase in solvent consumption and so there is a trade-off where a compromise has to be found in the event of an up scaled reaction. The reactions that cause solvent consumption during......Lignocellulosic biorefineries can be an important piece of the puzzle in fighting climate change. Present, biorefineries that produce ethanol from lignocellulose are challenged in working on market terms as the two product streams ethanol and lignin are low value products. The aim of this project...... has been to increase the value of the lignin stream. Recent regulations on shipping exhaust gasses in coastal waters dictate lower sulfur emissions which require ships to use low sulfur fuels for propulsion. This opens or expands a very large market for low sulfur fuels because a shift from...

  10. Fumaric Acid Production: A Biorefinery Perspective

    Directory of Open Access Journals (Sweden)

    Victor Martin-Dominguez

    2018-05-01

    Full Text Available The increasing scarcity of fossil raw materials, together with the need to develop new processes and technology based on renewable sources, and the need to dispose of an increasing amount of biomass-derived waste, have boosted the concept of biorefineries. Both 1G and 2G biorefineries are focused on the obtention of biofuels, chemicals, materials, food and feed from biomass, a renewable resource. Fumaric acid, and most compounds involved in the Kreb cycle, are considered key platform chemicals, not only for being acidulants and additives in the food industry, but also for their prospective use as monomers. This review is focused on the biotechnological processes based on fungi, mainly of the Rhizopus genus, whose main product is fumaric acid, on the process conditions, the bioreactors and modes of operation and on the purification of the acid once it is produced.

  11. Valorization of Sargassum muticum Biomass According to the Biorefinery Concept

    Directory of Open Access Journals (Sweden)

    Elena M. Balboa

    2015-06-01

    Full Text Available The biorefinery concept integrates processes and technologies for an efficient biomass conversion using all components of a feedstock. Sargassum muticum is an invasive brown algae which could be regarded as a renewable resource susceptible of individual valorization of the constituent fractions into high added-value compounds. Microwave drying technology can be proposed before conventional ethanol extraction of algal biomass, and supercritical fluid extraction with CO2 was useful to extract fucoxanthin and for the fractionation of crude ethanol extracts. Hydrothermal processing is proposed to fractionate the algal biomass and to solubilize the fucoidan and phlorotannin fractions. Membrane technology was proposed to concentrate these fractions and obtain salt- and arsenic-free saccharidic fractions. Based on these technologies, this study presents a multipurpose process to obtain six different products with potential applications for nutraceutical, cosmetic and pharmaceutical industries.

  12. Planning for an Integrated Research Experiment

    International Nuclear Information System (INIS)

    Barnard, J.J.; Ahle, L.E.; Bangerter, R.O.; Bieniosek, F.M.; Celata, C.M.; Faltens, A.; Friedman, A.; Grote, D.P.; Haber, I.; Henestroza, E.; Kishek, R.A.; Hoon, M.J.L. de; Karpenko, V.P.; Kwan, J.W.; Lee, E.P.; Logan, B.G.; Lund, S.M.; Meier, W.R.; Molvik, A.W.; Sangster, T.C.; Seidl, P.A.; Sharp, W.M.

    2000-01-01

    The authors describe the goals and research program leading to the Heavy Ion Integrated Research Experiment (IRE). They review the basic constraints which lead to a design and give examples of parameters and capabilities of an IRE. We also show design tradeoffs generated by the systems code IBEAM. A multi-pronged Phase 1 research effort is laying the groundwork for the Integrated Research Experiment. Experiment, technology development, theory, simulation, and systems studies are all playing major roles in this Phase I research. The key research areas are: (1) Source and injector (for investigation of a high brightness, multiple beam, low cost injector); (2) High current transport (to examine effects at full driver-scale line charge density, including the maximization of the beam filling-factor and control of electrons); (3) Enabling technology development (low cost and high performance magnetic core material, superconducting magnetic quadrupole arrays, insulators, and pulsers); and (4) Beam simulations and theory (for investigations of beam matching, specification of accelerator errors, studies of emittance growth, halo, and bunch compression, in the accelerator, and neutralization methods, stripping effects, spot size minimization in the chamber); and (5) Systems optimization (minimization of cost and maximization of pulse energy and beam intensity). They have begun the process of designing, simulating, and optimizing the next major heavy-ion induction accelerator, the IRE. This accelerator facility will, in turn, help provide the basis to proceed to the next step in the development of IFE as an attractive source of fusion energy

  13. Integrated Project Delivery (IPD Research Trends.

    Directory of Open Access Journals (Sweden)

    Kahvandi, Z.

    2017-07-01

    Full Text Available Integrated Project Delivery (IPD is introduced as a vibrant approach to enhance project implementation, having particular position in recent studies among construction researchers. This study analyzes the research trends on the field of IPD to provide an appropriate vision for future researchers in this specialized field. While so far no comprehensive research has been done in this field, this study provides a comprehensive review of existing studies through in-depth literature review method. This research evaluates studies conducted in the field of IPD, which is a basis for future researchers to improve conditions of IPD implementation in different countries. For that this study Using library studies, the trend of researches conducted on various concepts and domains during various years, has been investigated. Future studies can simply use the outputs of this research to shape their research flow on establishing continuing progress of IPD. The data obtained from descriptive analyses are illustrated quantitatively, followed by comprehensive analyses and discussion of the results. Moreover, this study concluded that during recent years, the trend of studies conducted about IPD has increased, particularly articles examined challenges. In the next step, more studies have been performed in the field of construction. Those articles are preferred that have evaluated principles, challenges, and solutions for resolving barriers. Proper IPD implementation facilitates enhanced share of information and early identification of stakeholders through a proper timing as vital keys to realize objectives of the construction projects, reduce risks, and increase the chance of project success.

  14. Physics Research Integrated Development Environment (PRIDE)

    International Nuclear Information System (INIS)

    Burton, J.; Cormell, L.

    1993-12-01

    Past efforts to implement a Software Engineering approach to High Energy Physics computing have been met with significant resistance and have been, in many cases, only marginally successful. At least a portion of the problem has been the Lick of an integrated development environment, tailored to High Energy Physics and incorporating a suite of Computer Aided Software Engineering tools. The Superconducting Super Collider Physics Research Division Computing Department is implementing pilot projects to develop just such an environment

  15. Toward a Computer-Aided Synthesis and Design of Biorefinery Networks: Data Collection and Management Using a Generic Modeling Approach

    DEFF Research Database (Denmark)

    Cheali, Peam; Gernaey, Krist; Sin, Gürkan

    2014-01-01

    that are needed among others to support the superstructure-based optimization studies. To this end, we first formulate an integrated thermochemical and biochemical biorefinery superstructure and then use a generic modeling approach to represent each processing technology in the superstructure. The generic model...

  16. Organosolv Fractionation of Softwood Biomass for Biofuel and Biorefinery Applications

    Directory of Open Access Journals (Sweden)

    Christos Nitsos

    2017-12-01

    Full Text Available Softwoods represent a significant fraction of the available lignocellulosic biomass for conversion into a variety of bio-based products. Its inherent recalcitrance, however, makes its successful utilization an ongoing challenge. In the current work the research efforts for the fractionation and utilization of softwood biomass with the organosolv process are reviewed. A short introduction into the specific challenges of softwood utilization, the development of the biorefinery concept, as well as the initial efforts for the development of organosolv as a pulping method is also provided for better understanding of the related research framework. The effect of organosolv pretreatment at various conditions, in the fractionation efficiency of wood components, enzymatic hydrolysis and bioethanol production yields is then discussed. Specific attention is given in the effect of the pretreated biomass properties such as residual lignin on enzymatic hydrolysis. Finally, the valorization of organosolv lignin via the production of biofuels, chemicals, and materials is also described.

  17. Early-Stage Design and Analysis of Biorefinery Networks

    DEFF Research Database (Denmark)

    Cheali, Peam; Quaglia, Alberto; Loureiro da Costa Lira Gargalo, Carina

    2016-01-01

    for the production of fuel, chemicals, and materials from renewable feedstock instead of fossil fuel. An emerging technology in response to these challenges is the biorefinery concept. The biorefinery is defined as the set of processes converting a bio‐based feedstock into products such as fuels, chemicals...

  18. Using product driven process synthesis in the biorefinery

    NARCIS (Netherlands)

    Kiskini, A.; Zondervan, E.; Wierenga, P.A.; Poiesz, E.; Gruppen, H.

    2015-01-01

    In this work, we propose the use of the product-driven process synthesis (PDPS) methodology for the product and process design stage in biorefinery. The aim of the biorefinery is to optimize the total use of the whole feedstock – with focus being on various products simultaneously – rather than to

  19. Superstructure-based optimization of biorefinery networks: Production of biodiesel

    DEFF Research Database (Denmark)

    Bertran, Maria-Ona; Orsi, Albert; Gani, Rafiqul

    2015-01-01

    through a practical case study for the production biodiesel from a variety of feedstock. The different biorefinery processing alternatives are represented in a superstructure and the associated data is collected and stored in a database. Once a specific biorefinery synthesis problem is formulated...

  20. Downstream processing of Isochrysis galbana: a step towards microalgal biorefinery

    NARCIS (Netherlands)

    Gilbert-López, B.; Mendiola, J.A.; Fontecha, J.; Broek, van den L.A.M.; Sijtsma, L.; Cifuentes, A.; Herrero, M.; Ibáñez, E.

    2015-01-01

    An algae-based biorefinery relies on the efficient use of algae biomass through its fractionation of several valuable/bioactive compounds that can be used in industry. If this biorefinery includes green platforms as downstream processing technologies able to fulfill the requirements of green

  1. Algal biorefinery-based industry: an approach to address fuel and food insecurity for a carbon-smart world.

    Science.gov (United States)

    Subhadra, Bobban

    2011-01-15

    Food and fuel production are intricately interconnected. In a carbon-smart society, it is imperative to produce both food and fuel sustainably. Integration of the emerging biorefinery concept with other industries can bring many environmental deliverables while mitigating several sustainability-related issues with respect to greenhouse gas emissions, fossil fuel usage, land use change for fuel production and future food insufficiency. A new biorefinery-based integrated industrial ecology encompasses the different value chain of products, coproducts, and services from the biorefinery industries. This paper discusses a framework to integrate the algal biofuel-based biorefinery, a booming biofuel sector, with other industries such as livestock, lignocellulosic and aquaculture. Using the USA as an example, this paper also illustrates the benefits associated with sustainable production of fuel and food. Policy and regulatory initiatives for synergistic development of the algal biofuel sector with other industries can bring many sustainable solutions for the future existence of mankind. Copyright © 2010 Society of Chemical Industry.

  2. Integration Research for Shaping Sustainable Regional Landscapes

    Directory of Open Access Journals (Sweden)

    David J. Brunckhorst

    2005-01-01

    Full Text Available Ecological and social systems are complex and entwined. Complex social-ecological systems interact in a multitude of ways at many spatial scales across time. Their interactions can contribute both positive and negative consequences in terms of sustainability and the context in which they exist affecting future landscape change. Non-metropolitan landscapes are the major theatre of interactions where large-scale alteration occurs precipitated by local to global forces of economic, social, and environmental change. Such regional landscape effects are critical also to local natural resource and social sustainability. The institutions contributing pressures and responses consequently shape future landscapes and in turn influence how social systems, resource users, governments, and policy makers perceive those landscapes and their future. Science and policy for “sustainable” futures need to be integrated at the applied “on-ground” level where products and effects of system interactions are fully included, even if unobserved. Government agencies and funding bodies often consider such research as “high-risk.” This paper provides some examples of interdisciplinary research that has provided a level of holistic integration through close engagement with landholders and communities or through deliberately implementing integrative and innovative on-ground experimental models. In retrospect, such projects have to some degree integrated through spatial (if not temporal synthesis, policy analysis, and (new or changed institutional arrangements that are relevant locally and acceptable in business, as well as at broader levels of government and geography. This has provided transferable outcomes that can contribute real options and adaptive capacity for suitable positive futures.

  3. 76 FR 13349 - Notice of Funding Availability (NOFA) for Repowering Assistance Payments to Eligible Biorefineries

    Science.gov (United States)

    2011-03-11

    ... Funding Availability (NOFA) for Repowering Assistance Payments to Eligible Biorefineries AGENCY: Rural... announces the acceptance of applications for payments to eligible biorefineries to encourage the use of... operation of these eligible biorefineries. To be eligible for payments, biorefineries must have been in...

  4. Biomass supply chain optimisation for Organosolv-based biorefineries.

    Science.gov (United States)

    Giarola, Sara; Patel, Mayank; Shah, Nilay

    2014-05-01

    This work aims at providing a Mixed Integer Linear Programming modelling framework to help define planning strategies for the development of sustainable biorefineries. The up-scaling of an Organosolv biorefinery was addressed via optimisation of the whole system economics. Three real world case studies were addressed to show the high-level flexibility and wide applicability of the tool to model different biomass typologies (i.e. forest fellings, cereal residues and energy crops) and supply strategies. Model outcomes have revealed how supply chain optimisation techniques could help shed light on the development of sustainable biorefineries. Feedstock quality, quantity, temporal and geographical availability are crucial to determine biorefinery location and the cost-efficient way to supply the feedstock to the plant. Storage costs are relevant for biorefineries based on cereal stubble, while wood supply chains present dominant pretreatment operations costs. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Biorefinery of microalgae - opportunities and constraints for different production scenarios.

    Science.gov (United States)

    Hariskos, Ioanna; Posten, Clemens

    2014-06-01

    In order to design economically feasible production processes it is necessary, as part of the biorefinery concept, to valorize all constituents of the microalgal biomass. Such an approach requires appropriate biorefinery side-process strategies to be adapted to production of the primary product. These strategies are particularly valid for microalgae, since the composition and amount of residual biomass can vary significantly depending on cell stoichiometry and cultivation techniques. This review investigates opportunities and constraints for biorefinery concepts in production scenarios for four different products from microalgae with different market volumes, including high- and medium-value products, whole cells and biodiesel. Approaches to close material and energy balances, as well as to adapt the biorefinery according to biological potential, process routes, and market needs are presented, which will further contribute to making the biorefinery concept a success. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. A New Proposal of Cellulosic Ethanol to Boost Sugarcane Biorefineries: Techno-Economic Evaluation

    Directory of Open Access Journals (Sweden)

    Juliana Q. Albarelli

    2014-01-01

    Full Text Available Commercial simulator Aspen Plus was used to simulate a biorefinery producing ethanol from sugarcane juice and second generation ethanol production using bagasse fine fraction composed of parenchyma cells (P-fraction. Liquid hot water and steam explosion pretreatment technologies were evaluated. The processes were thermal and water integrated and compared to a biorefinery producing ethanol from juice and sugarcane bagasse. The results indicated that after thermal and water integration, the evaluated processes were self-sufficient in energy demand, being able to sell the surplus electricity to the grid, and presented water intake inside the environmental limit for São Paulo State, Brazil. The processes that evaluated the use of the bagasse fine fraction presented higher economic results compared with the use of the entire bagasse. Even though, due to the high enzyme costs, the payback calculated for the biorefineries were higher than 8 years for all cases that considered second generation ethanol and the net present value for the investment was negative. The reduction on the enzyme load, in a way that the conversion rates could be maintained, is the limiting factor to make second generation ethanol competitive with the most immediate uses of bagasse: fuel for the cogeneration system to surplus electricity production.

  7. Cell disruption and lipid extraction for microalgal biorefineries: A review.

    Science.gov (United States)

    Lee, Soo Youn; Cho, Jun Muk; Chang, Yong Keun; Oh, You-Kwan

    2017-11-01

    The microalgae-based biorefinement process has attracted much attention from academic and industrial researchers attracted to its biofuel, food and nutraceutical applications. In this paper, recent developments in cell-disruption and lipid-extraction methods, focusing on four biotechnologically important microalgal species (namely, Chlamydomonas, Haematococcus, Chlorella, and Nannochloropsis spp.), are reviewed. The structural diversity and rigidity of microalgal cell walls complicate the development of efficient downstream processing methods for cell-disruption and subsequent recovery of intracellular lipid and pigment components. Various mechanical, chemical and biological cell-disruption methods are discussed in detail and compared based on microalgal species and status (wet/dried), scale, energy consumption, efficiency, solvent extraction, and synergistic combinations. The challenges and prospects of the downstream processes for the future development of eco-friendly and economical microalgal biorefineries also are outlined herein. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Integrating spaceflight human system risk research

    Science.gov (United States)

    Mindock, Jennifer; Lumpkins, Sarah; Anton, Wilma; Havenhill, Maria; Shelhamer, Mark; Canga, Michael

    2017-10-01

    NASA is working to increase the likelihood of exploration mission success and to maintain crew health, both during exploration missions and long term after return to Earth. To manage the risks in achieving these goals, a system modelled after a Continuous Risk Management framework is in place. ;Human System Risks; (Risks) have been identified, and 32 are currently being actively addressed by NASA's Human Research Program (HRP). Research plans for each of HRP's Risks have been developed and are being executed. Inter-disciplinary ties between the research efforts supporting each Risk have been identified; however, efforts to identify and benefit from these connections have been mostly ad hoc. There is growing recognition that solutions developed to address the full set of Risks covering medical, physiological, behavioural, vehicle, and organizational aspects of exploration missions must be integrated across Risks and disciplines. This paper discusses how a framework of factors influencing human health and performance in space is being applied as the backbone for bringing together sometimes disparate information relevant to the individual Risks. The resulting interrelated information enables identification and visualization of connections between Risks and research efforts in a systematic and standardized manner. This paper also discusses the applications of the visualizations and insights into research planning, solicitation, and decision-making processes.

  9. Fusion Ignition Research Experiment System Integration

    International Nuclear Information System (INIS)

    Brown, T.

    1999-01-01

    The FIRE (Fusion Ignition Research Experiment) configuration has been designed to meet the physics objectives and subsystem requirements in an arrangement that allows remote maintenance of in-vessel components and hands-on maintenance of components outside the TF (toroidal-field) boundary. The general arrangement consists of sixteen wedged-shaped TF coils that surround a free-standing central solenoid (CS), a double-wall vacuum vessel and internal plasma-facing components. A center tie rod is used to help support the vertical magnetic loads and a compression ring is used to maintain wedge pressure in the inboard corners of the TF coils. The magnets are liquid nitrogen cooled and the entire device is surrounded by a thermal enclosure. The double-wall vacuum vessel integrates cooling and shielding in a shape that maximizes shielding of ex-vessel components. The FIRE configuration development and integration process has evolved from an early stage of concept selection to a higher level of machine definition and component details. This paper describes the status of the configuration development and the integration of the major subsystem components

  10. Integrating body movement into attractiveness research.

    Science.gov (United States)

    Fink, Bernhard; Weege, Bettina; Neave, Nick; Pham, Michael N; Shackelford, Todd K

    2015-01-01

    People judge attractiveness and make trait inferences from the physical appearance of others, and research reveals high agreement among observers making such judgments. Evolutionary psychologists have argued that interest in physical appearance and beauty reflects adaptations that motivate the search for desirable qualities in a potential partner. Although men more than women value the physical appearance of a partner, appearance universally affects social perception in both sexes. Most studies of attractiveness perceptions have focused on third party assessments of static representations of the face and body. Corroborating evidence suggests that body movement, such as dance, also conveys information about mate quality. Here we review evidence that dynamic cues (e.g., gait, dance) also influence perceptions of mate quality, including personality traits, strength, and overall attractiveness. We recommend that attractiveness research considers the informational value of body movement in addition to static cues, to present an integrated perspective on human social perception.

  11. Techno-economic feasibility of waste biorefinery

    DEFF Research Database (Denmark)

    Shahzad, Khurram; Narodoslawsky, Michael; Sagir, Muhammad

    2017-01-01

    elaborated a process for the production of polyhydroxyalkanoate (PHA) biopolymers starting from diverse waste streams of the animal processing industry. This article provides a detailed economic analysis of PHA production from this waste biorefinery concept, encompassing the utilization of low......-quality biodiesel, offal material and meat and bone meal (MBM). Techno-economic analysis reveals that PHA production cost varies from 1.41 €/kg to 1.64 €/kg when considering offal on the one hand as waste, or, on the other hand, accounting its market price, while calculating with fixed costs for the co...

  12. Environmental impacts of a lignocellulose feedstock biorefinery system: An assessment

    International Nuclear Information System (INIS)

    Uihlein, Andreas; Schebek, Liselotte

    2009-01-01

    Biomass is a sustainable alternative to fossil energy carriers which are used to produce fuels, electricity, chemicals, and other goods. At the moment, the main biobased products are obtained by the conversion of biomass to basic products like starch, oil, and cellulose. In addition, some single chemicals and fuels are produced. Presently, concepts of biorefineries which will produce a multitude of biomass-derived products are discussed. Biorefineries are supposed to contribute to a more sustainable resource supply and to a reduction in greenhouse gas emissions. However, biobased products and fuels may also be associated with environmental disadvantages due to, e.g. land use or eutrophication of water. We performed a Life Cycle Assessment of a lignocellulose feedstock biorefinery system and compared it to conventional product alternatives. The biorefinery was found to have the greatest environmental impacts in the three categories: fossil fuel use, respiratory effects, and carcinogenics. The environmental impacts predominantly result from the provision of hydrochloric acid and to a smaller extent also from the provision of process heat. As the final configuration of the biorefinery cannot be determined yet, various variants of the biorefinery system were analysed. The optimum variant (acid and heat recoveries) yields better results than the fossil alternatives, with the total environmental impacts being approx. 41% lower than those of the fossil counterparts. For most biorefinery variants analysed, the environmental performance in some impact categories is better than that of the fossil counterparts while disadvantages can be seen in other categories.

  13. Researchers' experiences, positive and negative, in integrative landscape projects

    NARCIS (Netherlands)

    Tress, B.; Tress, G.; Fry, G.

    2005-01-01

    Integrative (interdisciplinary and transdisciplinary) landscape research projects are becoming increasingly common. As a result, researchers are spending a larger proportion of their professional careers doing integrative work, participating in shifting interdisciplinary teams, and cooperating

  14. Utilization of Ionic Liquids in Lignocellulose Biorefineries as Agents for Separation, Derivatization, Fractionation, or Pretreatment.

    Science.gov (United States)

    Peleteiro, Susana; Rivas, Sandra; Alonso, José L; Santos, Valentín; Parajó, Juan C

    2015-09-23

    Ionic liquids (ILs) can play multiple roles in lignocellulose biorefineries, including utilization as agents for the separation of selected compounds or as reaction media for processing lignocellulosic materials (LCM). Imidazolium-based ILs have been proposed for separating target components from LCM biorefinery streams, for example, the dehydration of ethanol-water mixtures or the extractive separation of biofuels (ethanol, butanol) or lactic acid from the respective fermentation broths. As in other industries, ILs are potentially suitable for removing volatile organic compounds or carbon dioxide from gaseous biorefinery effluents. On the other hand, cellulose dissolution in ILs allows homogeneous derivatization reactions to be carried out, opening new ways for product design or for improving the quality of the products. Imidazolium-based ILs are also suitable for processing native LCM, allowing the integral benefit of the feedstocks via separation of polysaccharides and lignin. Even strongly lignified materials can yield cellulose-enriched substrates highly susceptible to enzymatic hydrolysis upon ILs processing. Recent developments in enzymatic hydrolysis include the identification of ILs causing limited enzyme inhibition and the utilization of enzymes with improved performance in the presence of ILs.

  15. Biodiesel biorefinery: opportunities and challenges for microbial production of fuels and chemicals from glycerol waste.

    Science.gov (United States)

    Almeida, João R M; Fávaro, Léia C L; Quirino, Betania F

    2012-07-18

    The considerable increase in biodiesel production worldwide in the last 5 years resulted in a stoichiometric increased coproduction of crude glycerol. As an excess of crude glycerol has been produced, its value on market was reduced and it is becoming a "waste-stream" instead of a valuable "coproduct". The development of biorefineries, i.e. production of chemicals and power integrated with conversion processes of biomass into biofuels, has been singled out as a way to achieve economically viable production chains, valorize residues and coproducts, and reduce industrial waste disposal. In this sense, several alternatives aimed at the use of crude glycerol to produce fuels and chemicals by microbial fermentation have been evaluated. This review summarizes different strategies employed to produce biofuels and chemicals (1,3-propanediol, 2,3-butanediol, ethanol, n-butanol, organic acids, polyols and others) by microbial fermentation of glycerol. Initially, the industrial use of each chemical is briefly presented; then we systematically summarize and discuss the different strategies to produce each chemical, including selection and genetic engineering of producers, and optimization of process conditions to improve yield and productivity. Finally, the impact of the developments obtained until now are placed in perspective and opportunities and challenges for using crude glycerol to the development of biodiesel-based biorefineries are considered. In conclusion, the microbial fermentation of glycerol represents a remarkable alternative to add value to the biodiesel production chain helping the development of biorefineries, which will allow this biofuel to be more competitive.

  16. Recent advances in yeast cell-surface display technologies for waste biorefineries.

    Science.gov (United States)

    Liu, Zhuo; Ho, Shih-Hsin; Hasunuma, Tomohisa; Chang, Jo-Shu; Ren, Nan-Qi; Kondo, Akihiko

    2016-09-01

    Waste biorefinery aims to maximize the output of value-added products from various artificial/agricultural wastes by using integrated bioprocesses. To make waste biorefinery economically feasible, it is thus necessary to develop a low-cost, environment-friendly technique to perform simultaneous biodegradation and bioconversion of waste materials. Cell-surface display engineering is a novel, cost-effective technique that can auto-immobilize proteins on the cell exterior of microorganisms, and has been applied for use with waste biofinery. Through tethering different enzymes (e.g., cellulase, lipase, and protease) or metal-binding peptides on cell surfaces, various yeast strains can effectively produce biofuels and biochemicals from sugar/protein-rich waste materials, catalyze waste oils into biodiesels, or retrieve heavy metals from wastewater. This review critically summarizes recent applications of yeast cell-surface display on various types of waste biorefineries, highlighting its potential and future challenges with regard to commercializing this technology. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Techno-economic comparison of centralized versus decentralized biorefineries for two alkaline pretreatment processes.

    Science.gov (United States)

    Stoklosa, Ryan J; Del Pilar Orjuela, Andrea; da Costa Sousa, Leonardo; Uppugundla, Nirmal; Williams, Daniel L; Dale, Bruce E; Hodge, David B; Balan, Venkatesh

    2017-02-01

    In this work, corn stover subjected to ammonia fiber expansion (AFEX™) 1 pretreatment or alkaline pre-extraction followed by hydrogen peroxide post-treatment (AHP pretreatment) were compared for their enzymatic hydrolysis yields over a range of solids loadings, enzymes loadings, and enzyme combinations. Process techno-economic models were compared for cellulosic ethanol production for a biorefinery that handles 2000tons per day of corn stover employing a centralized biorefinery approach with AHP or a de-centralized AFEX pretreatment followed by biomass densification feeding a centralized biorefinery. A techno-economic analysis (TEA) of these scenarios shows that the AFEX process resulted in the highest capital investment but also has the lowest minimum ethanol selling price (MESP) at $2.09/gal, primarily due to good energy integration and an efficient ammonia recovery system. The economics of AHP could be made more competitive if oxidant loadings were reduced and the alkali and sugar losses were also decreased. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Towards lactic acid bacteria-based biorefineries.

    Science.gov (United States)

    Mazzoli, Roberto; Bosco, Francesca; Mizrahi, Itzhak; Bayer, Edward A; Pessione, Enrica

    2014-11-15

    Lactic acid bacteria (LAB) have long been used in industrial applications mainly as starters for food fermentation or as biocontrol agents or as probiotics. However, LAB possess several characteristics that render them among the most promising candidates for use in future biorefineries in converting plant-derived biomass-either from dedicated crops or from municipal/industrial solid wastes-into biofuels and high value-added products. Lactic acid, their main fermentation product, is an attractive building block extensively used by the chemical industry, owing to the potential for production of polylactides as biodegradable and biocompatible plastic alternative to polymers derived from petrochemicals. LA is but one of many high-value compounds which can be produced by LAB fermentation, which also include biofuels such as ethanol and butanol, biodegradable plastic polymers, exopolysaccharides, antimicrobial agents, health-promoting substances and nutraceuticals. Furthermore, several LAB strains have ascertained probiotic properties, and their biomass can be considered a high-value product. The present contribution aims to provide an extensive overview of the main industrial applications of LAB and future perspectives concerning their utilization in biorefineries. Strategies will be described in detail for developing LAB strains with broader substrate metabolic capacity for fermentation of cheaper biomass. Copyright © 2014 Elsevier Inc. All rights reserved.

  19. Biorefinery Demonstration Project Final Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, David [University of Georgia Research Foundation, Inc., Athens, GA (United States)

    2015-10-20

    In this project we focused on various aspects of biorefinery technology development including algal-biorefinery technology, thermochemical conversion of biomass to bio-oils and biochar; we tested characteristics and applications of biochars and evaluated nutrient cycling with wastewater treatment by the coupling of algal culture systems and anaerobic digestion. Key results include a method for reducing water content of bio-oil through atomized alcohol addition. The effect included increasing the pH and reducing the viscosity and cloud point of the bio-oil. Low input biochar production systems were evaluated via literature reviews and direct experimental work. Additionally, emissions were evaluated and three biochar systems were compared via a life cycle analysis. Attached growth systems for both algal cultivation and algal harvesting were found to be superior to suspended growth cultures. Nutrient requirements for algal cultivation could be obtained by the recycling of anaerobic digester effluents, thus experimentally showing that these two systems could be directly coupled. Twenty-two journal articles and six intellectual property applications resulted from the cumulative work that this project contributed to programmatically.

  20. Quantifying Supply Risk at a Cellulosic Biorefinery

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Jason K [Idaho National Laboratory; Jacobson, Jacob Jordan [Idaho National Laboratory; Cafferty, Kara Grace [Idaho National Laboratory; Lamers, Patrick [Idaho National Laboratory; Roni, MD S [Idaho National Laboratory

    2015-03-01

    In order to increase the sustainability and security of the nation’s energy supply, the U.S. Department of Energy through its Bioenergy Technology Office has set a vision for one billion tons of biomass to be processed for renewable energy and bioproducts annually by the year 2030. The Renewable Fuels Standard limits the amount of corn grain that can be used in ethanol conversion sold in the U.S, which is already at its maximum. Therefore making the DOE’s vision a reality requires significant growth in the advanced biofuels industry where currently three cellulosic biorefineries convert cellulosic biomass to ethanol. Risk mitigation is central to growing the industry beyond its infancy to a level necessary to achieve the DOE vision. This paper focuses on reducing the supply risk that faces a firm that owns a cellulosic biorefinery. It uses risk theory and simulation modeling to build a risk assessment model based on causal relationships of underlying, uncertain, supply driving variables. Using the model the paper quantifies supply risk reduction achieved by converting the supply chain from a conventional supply system (bales and trucks) to an advanced supply system (depots, pellets, and trains). Results imply that the advanced supply system reduces supply system risk, defined as the probability of a unit cost overrun, from 83% in the conventional system to 4% in the advanced system. Reducing cost risk in this nascent industry improves the odds of realizing desired growth.

  1. Quantifying Supply Risk at a Cellulosic Biorefinery

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Jason K.; Jacobson, Jacob J.; Cafferty, Kara G.; Lamers, Patrick; Roni, Mohammad S.

    2015-07-01

    In order to increase the sustainability and security of the nation’s energy supply, the U.S. Department of Energy through its Bioenergy Technology Office has set a vision for one billion tons of biomass to be processed for renewable energy and bioproducts annually by the year 2030. The Renewable Fuels Standard limits the amount of corn grain that can be used in ethanol conversion sold in the U.S, which is already at its maximum. Therefore making the DOE’s vision a reality requires significant growth in the advanced biofuels industry where currently three cellulosic biorefineries convert cellulosic biomass to ethanol. Risk mitigation is central to growing the industry beyond its infancy to a level necessary to achieve the DOE vision. This paper focuses on reducing the supply risk that faces a firm that owns a cellulosic biorefinery. It uses risk theory and simulation modeling to build a risk assessment model based on causal relationships of underlying, uncertain, supply driving variables. Using the model the paper quantifies supply risk reduction achieved by converting the supply chain from a conventional supply system (bales and trucks) to an advanced supply system (depots, pellets, and trains). Results imply that the advanced supply system reduces supply system risk, defined as the probability of a unit cost overrun, from 83% in the conventional system to 4% in the advanced system. Reducing cost risk in this nascent industry improves the odds of realizing desired growth.

  2. Preprocessing Moist Lignocellulosic Biomass for Biorefinery Feedstocks

    Energy Technology Data Exchange (ETDEWEB)

    Neal Yancey; Christopher T. Wright; Craig Conner; J. Richard Hess

    2009-06-01

    Biomass preprocessing is one of the primary operations in the feedstock assembly system of a lignocellulosic biorefinery. Preprocessing is generally accomplished using industrial grinders to format biomass materials into a suitable biorefinery feedstock for conversion to ethanol and other bioproducts. Many factors affect machine efficiency and the physical characteristics of preprocessed biomass. For example, moisture content of the biomass as received from the point of production has a significant impact on overall system efficiency and can significantly affect the characteristics (particle size distribution, flowability, storability, etc.) of the size-reduced biomass. Many different grinder configurations are available on the market, each with advantages under specific conditions. Ultimately, the capacity and/or efficiency of the grinding process can be enhanced by selecting the grinder configuration that optimizes grinder performance based on moisture content and screen size. This paper discusses the relationships of biomass moisture with respect to preprocessing system performance and product physical characteristics and compares data obtained on corn stover, switchgrass, and wheat straw as model feedstocks during Vermeer HG 200 grinder testing. During the tests, grinder screen configuration and biomass moisture content were varied and tested to provide a better understanding of their relative impact on machine performance and the resulting feedstock physical characteristics and uniformity relative to each crop tested.

  3. Synthesis of Optimal Processing Pathway for Microalgae-based Biorefinery under Uncertainty

    DEFF Research Database (Denmark)

    Rizwan, Muhammad; Lee, Jay H.; Gani, Rafiqul

    2015-01-01

    decision making, we propose a systematic framework for the synthesis and optimal design of microalgae-based processing network under uncertainty. By incorporating major uncertainties into the biorefinery superstructure model we developed previously, a stochastic mixed integer nonlinear programming (s......The research in the field of microalgae-based biofuels and chemicals is in early phase of the development, and therefore a wide range of uncertainties exist due to inconsistencies among and shortage of technical information. In order to handle and address these uncertainties to ensure robust......MINLP) problem is formulated for determining the optimal biorefinery structure under given parameter uncertainties modelled as sampled scenarios. The solution to the sMINLP problem determines the optimal decisions with respect to processing technologies, material flows, and product portfolio in the presence...

  4. Bridging the gap between feedstock growers and users: the study of a coppice poplar-based biorefinery.

    Science.gov (United States)

    Dou, Chang; Gustafson, Rick; Bura, Renata

    2018-01-01

    In the biofuel industry, land productivity is important to feedstock growers and conversion process product yield is important to the biorefinery. The crop productivity, however, may not positively correlate with bioconversion yield. Therefore, it is important to evaluate sugar yield and biomass productivity. In this study, 2-year-old poplar trees harvested in the first coppice cycle, including one low-productivity hybrid and one high-productivity hybrid, were collected from two poplar tree farms. Through steam pretreatment and enzymatic hydrolysis, the bioconversion yields of low- and high-productivity poplar hybrids were compared for both sites. The low-productivity hybrids had 9-19% higher sugar yields than the high-productivity hybrids, although they have the similar chemical composition. Economic calculations show the impact on the plantation and biorefinery of using the two feedstocks. Growing a high-productivity hybrid means the land owner would use 11-26% less land (which could be used for other crops) or collect $2.53-$3.46 MM/year extra revenue from the surplus feedstock. On the other side, the biorefinery would receive 5-10% additional revenue using the low-productivity hybrid. We propose a business model based on the integration of the plantation and the biorefinery. In this model, different feedstocks are assessed using a metric of product tonnage per unit land per year. Use of this new economic metric bridges the gap between feedstock growers and users to maximize the overall production efficiency.

  5. Enzyme recycling in lignocellulosic biorefineries

    DEFF Research Database (Denmark)

    Jørgensen, Henning; Pinelo, Manuel

    2017-01-01

    platform. Cellulases are the most important enzymes required in this process, but the complex nature of lignocellulose requires several other enzymes (hemicellulases and auxiliary enzymes) for efficient hydrolysis. Enzyme recycling increases the catalytic productivity of the enzymes by reusing them...... for several batches of hydrolysis, and thereby reduces the overall cost associated with the hydrolysis. Research on this subject has been ongoing for many years and several promising technologies and methods have been developed and demonstrated. But only in a very few cases have these technologies been...... upscaled and tested in industrial settings, mainly because of many difficulties with recycling of enzymes from the complex lignocellulose hydrolyzate at industrially relevant conditions, i.e., high solids loadings. The challenges are associated with the large number of different enzymes required...

  6. Research integrity and misconduct: a clarification of the concepts.

    Science.gov (United States)

    Khanyile, T D; Duma, S; Fakude, L P; Mbombo, N; Daniels, F; Sabone, M S

    2006-03-01

    The commercialization of research and the ever changing scientific environment has led scholars to shift the focus from promoting research integrity to regulating misconduct. As a result, most literature explains research integrity in terms of avoidance of misconduct. The purpose of the paper is to stimulate reflection and discussion on research integrity and research misconduct. This article explores the meaning of research integrity and research misconduct, and how research integrity can be promoted to ensure safer research and scholarship. We believe that the discussion can help clarify some hazy areas in the research and publication processes, and appreciate some crucial aspects that they may have seen taken for granted. The purpose of this article is to share with the readers some clarification or analysis of the two concepts namely: research integrity and misconduct. The objectives are: (1) To explore and analyse the concepts of research integrity and research misconduct from the educational or developmental perspective and not the legal perspective as others in literature have done. (2) To stimulate the reflection and discussion on strategies to promote research integrity and thus prevent research misconduct Literature review and concept analysis was undertaken to clarify the two concepts. We argue that the two concepts can be viewed along a continuum, i.e. where research integrity ends, research misconduct starts. We also argue that it is the responsibility of the research community at large to always ensure that the scientific ethics balance is maintained throughout the research process to ensure research integrity and avoid research misconduct. We also argue that research integrity is interlinked with morality while misconduct is interlinked with immorality.

  7. The integrated system of research quality (quality of the research and research quality

    Directory of Open Access Journals (Sweden)

    M. V. Yurasova

    2014-01-01

    Full Text Available The necessity of the use of research for decision-making on the information received, are considered typical examples of the use of integrated systems research in the practice of the organization, approaches and assess the quality of research and study quality as a subject of study.

  8. Economic risk analysis and critical comparison of optimal biorefinery concepts

    DEFF Research Database (Denmark)

    Cheali, Peam; Posada, John A.; Gernaey, Krist

    2016-01-01

    In this paper, eight optimal biorefinery concepts for biofuels and biochemicals production are critically analyzed and compared in terms of their techno-economic performance and associated economic risks against historical market fluctuations. The investigated biorefinery concepts consider...... different combinations of biomass feedstock (lignocellulosic versus algal) and conversion technologies (biochemical versus thermochemical). In addition, the economic performance of each biorefinery concept is tested assuming a sudden drop in oil prices in order to compare the fitness/survival of each...... concept under extreme market disturbances. The analyses reveal amongst others that: (i) lignocellulosic bioethanol production is not economically feasible considering a drop in oil prices (a negative internal rate of return); (ii) a multi-product biorefinery concept, where bioethanol is upgraded to higher...

  9. Early stage design and analysis of biorefinery networks

    DEFF Research Database (Denmark)

    Sin, Gürkan

    2013-01-01

    Recent work regarding biorefineries resulted in many competing concepts and technologies for conversion of renewable bio-based feedstock into many promising products including fuels, chemicals, materials, etc. The design of a biorefinery process requires, at its earlier stages, the selection...... of the process configuration which exhibits the best performances, for a given set of economical, technical and environmental criteria. To this end, we formulate a computer-aided framework as an enabling technology for early stage design and analysis of biorefineries. The tool represents different raw materials......, different products and different available technologies and proposes a conceptual (early stage) biorefinery network. This network can then be the basis for further detailed and rigorous model-based studies. In this talk, we demonstrate the application of the tool for generating an early stage optimal...

  10. Integrative Role Of Cinematography In Biomechanics Research

    Science.gov (United States)

    Zernicke, Ronald F.; Gregor, Robert J.

    1982-02-01

    Cinematography is an integral element in the interdisciplinary biomechanics research conducted in the Department of Kinesiology at the University of California, Los Angeles. For either an isolated recording of a movement phenomenon or as a recording component which is synchronized with additional transducers and recording equipment, high speed motion picture film has been effectively incorporated into resr'arch projects ranging from two and three dimensional analyses of human movements, locomotor mechanics of cursorial mammals and primates, to the structural responses and dynamic geometries of skeletal muscles, tendons, and ligaments. The basic equipment used in these studies includes three, 16 mm high speed, pin-registered cameras which have the capacity for electronic phase-locking. Crystal oscillators provide the generator pulses to synchronize the timing lights of the cameras and the analog-to-digital recording equipment. A rear-projection system with a sonic digitizer permits quantification of film coordinates which are stored on computer disks. The capacity for synchronizing the high speed films with additional recording equipment provides an effective means of obtaining not only position-time data from film, but also electromyographic, force platform, tendon force transducer, and strain gauge recordings from tissues or moving organisms. During the past few years, biomechanics research which comprised human studies has used both planar and three-dimensional cinematographic techniques. The studies included planar analyses which range from the gait characteristics of lower extremity child amputees to the running kinematics and kinetics of highly skilled sprinters and long-distance runners. The dynamics of race cycling and kinetics of gymnastic maneuvers were studied with cinematography and either a multi-dimensional force platform or a bicycle pedal with strain gauges to determine the time histories of the applied forces. The three-dimensional technique

  11. Optimizing Biorefinery Design and Operations via Linear Programming Models

    Energy Technology Data Exchange (ETDEWEB)

    Talmadge, Michael; Batan, Liaw; Lamers, Patrick; Hartley, Damon; Biddy, Mary; Tao, Ling; Tan, Eric

    2017-03-28

    The ability to assess and optimize economics of biomass resource utilization for the production of fuels, chemicals and power is essential for the ultimate success of a bioenergy industry. The team of authors, consisting of members from the National Renewable Energy Laboratory (NREL) and the Idaho National Laboratory (INL), has developed simple biorefinery linear programming (LP) models to enable the optimization of theoretical or existing biorefineries. The goal of this analysis is to demonstrate how such models can benefit the developing biorefining industry. It focuses on a theoretical multi-pathway, thermochemical biorefinery configuration and demonstrates how the biorefinery can use LP models for operations planning and optimization in comparable ways to the petroleum refining industry. Using LP modeling tools developed under U.S. Department of Energy's Bioenergy Technologies Office (DOE-BETO) funded efforts, the authors investigate optimization challenges for the theoretical biorefineries such as (1) optimal feedstock slate based on available biomass and prices, (2) breakeven price analysis for available feedstocks, (3) impact analysis for changes in feedstock costs and product prices, (4) optimal biorefinery operations during unit shutdowns / turnarounds, and (5) incentives for increased processing capacity. These biorefinery examples are comparable to crude oil purchasing and operational optimization studies that petroleum refiners perform routinely using LPs and other optimization models. It is important to note that the analyses presented in this article are strictly theoretical and they are not based on current energy market prices. The pricing structure assigned for this demonstrative analysis is consistent with $4 per gallon gasoline, which clearly assumes an economic environment that would favor the construction and operation of biorefineries. The analysis approach and examples provide valuable insights into the usefulness of analysis tools for

  12. European biorefineries: Implications for land, trade and employment

    International Nuclear Information System (INIS)

    Thornley, Patricia; Chong, Katie; Bridgwater, Tony

    2014-01-01

    Highlights: • Five diverse European member states could support around 30 biorefineries. • The facilities would create around 2 million man-years of employment. • Biorefineries create more jobs per unit of feedstock than bioelectricity plants. • Contribution to national GDP is very small; but agriculturally significant. • Increased straw demand could indirectly increase greenhouse gas emissions. - Abstract: Biorefineries are expected to play a major role in a future low carbon economy and substantial investments are being made to support this vision. However, it is important to consider the wider socio-economic impacts of such a transition. This paper quantifies the potential trade, employment and land impacts of economically viable European biorefinery options based on indigenous straw and wood feedstocks. It illustrates how there could be potential for 70–80 European biorefineries, but not hundreds. A single facility could generate tens of thousands of man-years of employment and employment creation per unit of feedstock is higher than for biomass power plants. However, contribution to national GDP is unlikely to exceed 1% in European member states, although contributions to national agricultural productivity may be more significant, particularly with straw feedstocks. There is also a risk that biorefinery development could result in reduced rates of straw incorporation into soil, raising concerns that economically rational decisions to sell rather than reincorporate straw could result in increased agricultural land-use or greenhouse gas emissions

  13. Electric Vehicle Grid Integration | Transportation Research | NREL

    Science.gov (United States)

    Electric Vehicle Grid Integration Electric Vehicle Grid Integration Illustration of a house with a in the garage, is connected via a power cord to a household outlet. A sustainable transportation sustainable transportation technologies to increase the capacity, efficiency, and stability of the grid

  14. PhD students and integrative research

    NARCIS (Netherlands)

    Fry, G.; Tress, B.; Tress, G.

    2006-01-01

    The training of PhD students is currently very dynamic and varies widely from place to place. We present some examples of this variation and comment on how it may affect the way PhD students cope with integrative studies. Our focus is on the training needs of PhD students studying integrative

  15. The brave new researcher of doctoral integrity training

    DEFF Research Database (Denmark)

    Sarauw, Laura Louise; Degn, Lise; Ørberg, Jakob Williams

    2018-01-01

    Research integrity has become a major concern for both higher education institutions and research policy makers in the recent decades, and since 2000 there has been an explosive boom of national and international codes and agreements on ‘responsible conduct of research’ and ’research integrity...... are constructed and negotiated within the courses. The field of research integrity teaching is still emergent and course leaders and teachers are often key actors in framing and promoting certain understandings of research integrity in their discipline. Hence, the four research integrity courses explored...... the following questions: 1) What attitudes, behaviors, and notions of the ‘ideal researcher’ aree constructed and promoted in the local research integrity training for PhD fellows? 2) How do these ideals relate to other concerns and pressures among the course leaders, teachers and PhD fellows? 3) Are other...

  16. Enzymatic cell disruption of microalgae biomass in biorefinery processes.

    Science.gov (United States)

    Demuez, Marie; Mahdy, Ahmed; Tomás-Pejó, Elia; González-Fernández, Cristina; Ballesteros, Mercedes

    2015-10-01

    When employing biotechnological processes for the procurement of biofuels and bio-products from microalgae, one of the most critical steps affecting economy and yields is the "cell disruption" stage. Currently, enzymatic cell disruption has delivered effective and cost competitive results when compared to mechanical and chemical cell disruption methods. However, the introduction of enzymes implies additional associated cost within the overall process. In order to reduce this cost, autolysis of microalgae is proposed as alternative enzymatic cell disruption method. This review aims to provide the state of the art of enzymatic cell disruption treatments employed in biorefinery processes and highlights the use of endopeptidases. During the enzymatic processes of microalgae life cycle, some lytic enzymes involved in cell division and programmed cell death have been proven useful in performing cell lysis. In this context, the role of endopeptidases is emphasized. Mirroring these natural events, an alternative cell disruption approach is proposed and described with the potential to induce the autolysis process using intrinsic cell enzymes. Integrating induced autolysis within biofuel production processes offers a promising approach to reduce overall global costs and energetic input associated with those of current cell disruption methods. A number of options for further inquiry are also discussed. © 2015 Wiley Periodicals, Inc.

  17. Knowledge management in a waste based biorefinery in the QbD paradigm.

    Science.gov (United States)

    Rathore, Anurag S; Chopda, Viki R; Gomes, James

    2016-09-01

    Shifting resource base from fossil feedstock to renewable raw materials for production of chemical products has opened up an area of novel applications of industrial biotechnology-based process tools. This review aims to provide a concise and focused discussion on recent advances in knowledge management to facilitate efficient and optimal operation of a biorefinery. Application of quality by design (QbD) and process analytical technology (PAT) as tools for knowledge creation and management at different levels has been highlighted. Role of process integration, government policies, knowledge exchange through collaboration, and use of databases and computational tools have also been touched upon. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Dual purpose microalgae-bacteria-based systems that treat wastewater and produce biodiesel and chemical products within a biorefinery.

    Science.gov (United States)

    Olguín, Eugenia J

    2012-01-01

    , are highlighted as very relevant fields of research. The species selection may depend on various factors, such as the biomass and lipid productivity of each strain, the characteristics of the wastewater, the original habitat of the strain and the climatic conditions in the treatment plant, among others. Some alternative technologies aimed at harvesting biomass at a low cost, such as cell immobilization, biofilm formation, flocculation and bio-flocculation, are also reviewed. Finally, a Biorefinery design is presented that integrates the treatment of municipal wastewater with the recovery of oleaginous microalgae, together with the use of seawater supplemented with anaerobically digested piggery waste for cultivating Arthrospira (Spirulina) and producing biogas, biodiesel, hydrogen and other high added value products. Such strategies offer new opportunities for the cost-effective and competitive production of biofuels along with valuable non-fuel products. Copyright © 2012 Elsevier Inc. All rights reserved.

  19. Research | Integral geometry and advanced stereology

    DEFF Research Database (Denmark)

    Christensen, Sabrina Tang; Plessis, Andrew du

    2015-01-01

    This contribution to the journal CSGB annual report summarises my research on topology and digital image analysis until 2014.......This contribution to the journal CSGB annual report summarises my research on topology and digital image analysis until 2014....

  20. Research | Integral geometry and advanced stereology

    DEFF Research Database (Denmark)

    Christensen, Sabrina Tang; Plessis, Andrew du

    2014-01-01

    This contribution to the journal CSGB annual report summarises my research on topology and digital image analysis until 2013.......This contribution to the journal CSGB annual report summarises my research on topology and digital image analysis until 2013....

  1. Recovery Act: Alpena Biorefinery and Alpena Biorefinery Lignin Separation Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Retsina, Theodora [American Process Inc., Atlanta, GA (United States)

    2016-12-19

    The Alpena Biorefinery (AB) was constructed in Alpena, Michigan, at the Decorative Panels International hardboard manufacturing facility. The goal of the AB was to demonstrate a modular, technically successful, and financially viable process of making cellulosic ethanol from woody biomass extract at wood processing facilities. At full capacity, the AB can produce 894,200 gallons per year of cellulosic ethanol and 696,000 gallons per year of aqueous potassium acetate, using extract from northern hardwood and aspen woodchips feedstock. The project objectives and the value proposition of AB promote the national goals of energy independence, greenhouse gas reduction, and green job creation and retention. A successful outcome of the Alpena Biorefinery project has been commercial sales of the first ever cellulosic ethanol RINS generated from woody biomass in the US, under the EPA’s Renewable Fuels Standard Program. We believe that American Process is also likely the first company in the world to produce commercial quantities of cellulosic ethanol from mixed forest residue. Life Cycle Analysis performed by Michigan Institute of Technology found that the entire life cycle greenhouse gas emissions from the plant’s cellulosic ethanol were only 25 percent that of petroleum-based gasoline. They found the potassium acetate runway de-icer coproduct generates up to 45 percent less greenhouse gases than the production of conventional potassium acetate. The Alpena Biorefinery project created 31 permanent jobs for direct employees and helped retain 200 jobs associated with the existing Decorative Panels International facility, by increasing its economic viability through significant savings in waste water treatment costs. The AB project has been declared a Michigan Center of Energy Excellence and was awarded a $4 million State of Michigan grant. The project also received New Market Tax Credit financing for locating in an economically distressed community. All other equity funds

  2. Toward an Integrative Framework of Indigenous Research

    DEFF Research Database (Denmark)

    Li, Peter Ping

    2012-01-01

    It has long been recognized that indigenous research should be helpful, if not essential, for an adequate understanding of local phenomena. The indigenous approach is consistent with, but extends beyond, the repeated calls for contextualizing management and organization research. However, the cha......It has long been recognized that indigenous research should be helpful, if not essential, for an adequate understanding of local phenomena. The indigenous approach is consistent with, but extends beyond, the repeated calls for contextualizing management and organization research. However...

  3. Integrating Mediators and Moderators in Research Design

    Science.gov (United States)

    MacKinnon, David P.

    2011-01-01

    The purpose of this article is to describe mediating variables and moderating variables and provide reasons for integrating them in outcome studies. Separate sections describe examples of moderating and mediating variables and the simplest statistical model for investigating each variable. The strengths and limitations of incorporating mediating…

  4. Research ethics and integrity for social scientists beyond regulatory compliance

    CERN Document Server

    Israel, Mark

    2014-01-01

    This book explores recent developments and debates around researching ethically and with integrity, and complying with ethical requirements, and has been updated and expanded to now cover issues relating to international, indigenous, interdisciplinary and internet research.  

  5. 76 FR 13351 - Notice of Funds Availability (NOFA) Inviting Applications for the Biorefinery Assistance Program

    Science.gov (United States)

    2011-03-11

    ... commercial-scale biorefineries or for the retrofitting of existing facilities using eligible technology for... biorefineries and the retrofitting of existing facilities using eligible technology for the development of... provide for the development, construction, and/or retrofitting of commercial biorefineries using eligible...

  6. European Universities' Guidance on Research Integrity and Misconduct.

    Science.gov (United States)

    Aubert Bonn, Noémie; Godecharle, Simon; Dierickx, Kris

    2017-02-01

    Research integrity is imperative to good science. Nonetheless, many countries and institutions develop their own integrity guidance, thereby risking incompatibilities with guidance of collaborating institutions. We retrieved guidance for academic integrity and misconduct of 18 universities from 10 European countries and investigated accessibility, general content, principles endorsed, and definitions of misconduct. Accessibility and content differ substantially between institutions. There are general trends of common principles of integrity and definitions of misconduct, yet differences remain. Parallel with previous research, we distinguish different approaches in integrity guidance; one emphasizes broad values of integrity, and the other details negative behaviors of misconduct. We propose that a balance between both approaches is necessary to preserve trust, meaning, and realism of guidance on research integrity.

  7. Lignocellulosic biorefinery as a model for sustainable development of biofuels and value added products.

    Science.gov (United States)

    De Bhowmick, Goldy; Sarmah, Ajit K; Sen, Ramkrishna

    2018-01-01

    A constant shift of society's dependence from petroleum-based energy resources towards renewable biomass-based has been the key to tackle the greenhouse gas emissions. Effective use of biomass feedstock, particularly lignocellulosic, has gained worldwide attention lately. Lignocellulosic biomass as a potent bioresource, however, cannot be a sustainable alternative if the production cost is too high and/ or the availability is limited. Recycling the lignocellulosic biomass from various sources into value added products such as bio-oil, biochar or other biobased chemicals in a bio-refinery model is a sensible idea. Combination of integrated conversion techniques along with process integration is suggested as a sustainable approach. Introducing 'series concept' accompanying intermittent dark/photo fermentation with co-cultivation of microalgae is conceptualised. While the cost of downstream processing for a single type of feedstock would be high, combining different feedstocks and integrating them in a bio-refinery model would lessen the production cost and reduce CO 2 emission. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Sustainability Assessment of a Biorefinery Complex in Thailand

    Directory of Open Access Journals (Sweden)

    Pariyapat Nilsalab

    2011-03-01

    Full Text Available In this paper, a biorefinery complex in Thailand was assessed vis-à-vis sustainability. The complex studied includes plantations of sugarcane and a biorefinery system composed of several units including, a sugar mill, power plant, ethanol factory and fertilizer plant. The assessment aimed at evaluating the environmental and socio-economic implications relating to molasses-based ethanol production and use, and maximized utilization of the biomass materials produced as part of the biorefinery complex. Global warming potential, human development index and total value added are the three indicators that were selected to perform the assessment. The results obtained revealed that the maximization of biomass utilization at the level of the biorefinery complex provide greenhouse gases emissions reduction benefits, enhanced living conditions for sugarcane farmers and employees of the biorefinery, and economic benefits, particularly with regard to profit and income generation. These results could serve as a first step to further improve and design indicators for sustainability assessment of biomass utilization.

  9. The territorial biorefinery as a new business model

    Directory of Open Access Journals (Sweden)

    Ion Lucian Ceapraz

    2016-05-01

    Full Text Available The transition toward more sustainable industries opens the way for alternative solutions based upon new economic models using agricultural inputs or biomass to substitute oil-based inputs. In this context different generations of biorefinery complexes are evolving rapidly and highlight the numerous possibilities for the organization of processing activities, from supply to final markets. The evolution of these biorefineries has followed two main business models, the port biorefinery, based on the import of raw materials, and the territorial biorefinery, based on strong relationships with local (or regional supply bases. In this article we focus on the concept of the ‘territorial biorefinery’, seen as a new business model. We develop the idea of a link between the biorefinery and its territory through several relevant theoretical approaches and demonstrate that the definition of ‘territorial biorefinery’ does not achieve, from these theoretical backgrounds, a consensus. More importantly, we emphasise that the theoretical assumptions underlying the different definitions used should be made explicit in order to facilitate the manner in which practioners study, develop and set up businesses of this kind.

  10. Using Action Research Projects to Examine Teacher Technology Integration Practices

    Science.gov (United States)

    Dawson, Kara

    2012-01-01

    This study examined the technology integration practices of teachers involved in a statewide initiative via one cycle of action research. It differs from other studies of teacher technology integration practices because it simultaneously involved and provided direct benefits to teachers and researchers. The study used thematic analysis to provide…

  11. Integrating Research Skills Training into Non--Research Methods Courses

    Science.gov (United States)

    Woolf, Jules

    2014-01-01

    Research skills are a valued commodity by industry and university administrators. Despite the importance placed on these skills students typically dislike taking research method courses where these skills are learned. However, training in research skills does not necessarily have to be confined to these courses. In this study participants at a…

  12. Biorefinery of instant noodle waste to biofuels.

    Science.gov (United States)

    Yang, Xiaoguang; Lee, Sang Jun; Yoo, Hah Young; Choi, Han Suk; Park, Chulhwan; Kim, Seung Wook

    2014-05-01

    Instant noodle waste, one of the main residues of the modern food industry, was employed as feedstock to convert to valuable biofuels. After isolation of used oil from the instant noodle waste surface, the starch residue was converted to bioethanol by Saccharomyces cerevisiae K35 with simultaneous saccharification and fermentation (SSF). The maximum ethanol concentration and productivity was 61.1g/l and 1.7 g/lh, respectively. After the optimization of fermentation, ethanol conversion rate of 96.8% was achieved within 36 h. The extracted oil was utilized as feedstock for high quality biodiesel conversion with typical chemical catalysts (KOH and H2SO4). The optimum conversion conditions for these two catalysts were estimated; and the highest biodiesel conversion rates were achieved 98.5% and 97.8%, within 2 and 3h, respectively. The high conversion rates of both bioethanol and biodiesel demonstrate that novel substrate instant noodle waste can be an attractive biorefinery feedstock in the biofuels industry. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. Integration of Social Sciences in Nuclear Research

    International Nuclear Information System (INIS)

    Bovy, M.; Eggermont, G.

    2002-01-01

    In 1998, SCK-CEN initiated a programme to integrate social sciences into its scientific and technological projects. Activities were started on the following issues: (1) sustainable development; (2) ethics and decision making in nuclear waste management (transgenerational ethics/retrievability; socio-psychological aspect and local involvement); (3) law and liability (medical applications and the basic safety standards implementation); (4) decision making (emergency management); safety culture; ALARA and ethical choices in protection). Two working groups were created to discuss two broad items: (1) ethical choices in radiation protection; and (2) the role and culture of the expert. Progress and major achievements in SCK-CEN's social science programme in 2001 are summarised

  14. Clarifying the Imperative of Integration Research for Sustainable Environmental Management

    Directory of Open Access Journals (Sweden)

    Stephen Dovers

    2005-01-01

    Full Text Available This paper discusses why integration is important in doing research for developing policy and practice of sustainable environmental management. The imperative of integration includes environmental, social, economic, and other disciplinary considerations, as well as stakeholder interests. However, what is meant by integration is not always clear. While the imperative is being increasingly enunciated, the challenges it presents are difficult and indicate a long term pursuit. This paper clarifies the different dimensions of integration, as an important preliminary step toward advancing mutual understanding and the development of approaches. The paper identifies the driving forces for integration, discusses when integration is required, categorises forms of integration, and proposes principles to inform research programs and projects.

  15. Fusion Ignition Research Experiment System Integration

    International Nuclear Information System (INIS)

    Brown, T.

    2000-01-01

    This paper describes the current status of the FIRE configuration and the integration of the major subsystem components. FIRE has a major radius of 2 m, a field on axis of 10T, a plasma current of 6.4 MA. It is capable of 18 second pulses when operated with DT and 26 s when operated with DD. The general arrangement consists of sixteen wedged TF coils that surround a free standing central solenoid, a double wall vacuum vessel and internal plasma facing components that are segmented for maintenance through horizontal ports. Large rings located outside the TF coils are used to obtain a load balance between wedging of the intercoil case structure and wedging at the upper/lower inboard corners of the TF coil winding. The magnets are liquid nitrogen cooled and the entire device is surrounded by a thermal enclosure. The double wall vacuum vessel integrates cooling and shielding in a shape that maximizes shielding of ex-vessel components. Within the vacuum vessel, plasma-facing components frame the plasma. First wall tiles are attached directly to inboard and outboard vacuum vessel walls. The divertor is designed for a high triangularity, double-null plasma with a short inner null point-to-wall distance and near vertical outer divertor flux line. The FIRE configuration has been developed to meet the physics objectives and subsystem requirements in an arrangement that allows remote maintenance of in-vessel components and hands-on maintenance of components outside the TF boundary

  16. Tracking Research Data Footprints via Integration with Research Graph

    Science.gov (United States)

    Evans, B. J. K.; Wang, J.; Aryani, A.; Conlon, M.; Wyborn, L. A.; Choudhury, S. A.

    2017-12-01

    The researcher of today is likely to be part of a team that will use subsets of data from at least one, if not more external repositories, and that same data could be used by multiple researchers for many different purposes. At best, the repositories that host this data will know who is accessing their data, but rarely what they are using it for, resulting in funders of data collecting programs and data repositories that store the data unlikely to know: 1) which research funding contributed to the collection and preservation of a dataset, and 2) which data contributed to high impact research and publications. In days of funding shortages there is a growing need to be able to trace the footprint a data set from the originator that collected the data to the repository that stores the data and ultimately to any derived publications. The Research Data Alliance's Data Description Registry Interoperability Working Group (DDRIWG) has addressed this problem through the development of a distributed graph, called Research Graph that can map each piece of the research interaction puzzle by building aggregated graphs. It can connect datasets on the basis of co-authorship or other collaboration models such as joint funding and grants and can connect research datasets, publications, grants and researcher profiles across research repositories and infrastructures such as DataCite and ORCID. National Computational Infrastructure (NCI) in Australia is one of the early adopters of Research Graph. The graphic view and quantitative analysis helps NCI track the usage of their National reference data collections thus quantifying the role that these NCI-hosted data assets play within the funding-researcher-data-publication-cycle. The graph can unlock the complex interactions of the research projects by tracking the contribution of datasets, the various funding bodies and the downstream data users. RMap Project is a similar initiative which aims to solve complex relationships among

  17. Controlling accumulation of fermentation inhibitors in biorefinery recycle water using microbial fuel cells

    Directory of Open Access Journals (Sweden)

    Vishnivetskaya Tatiana A

    2009-04-01

    Full Text Available Abstract Background Microbial fuel cells (MFC and microbial electrolysis cells are electrical devices that treat water using microorganisms and convert soluble organic matter into electricity and hydrogen, respectively. Emerging cellulosic biorefineries are expected to use large amounts of water during production of ethanol. Pretreatment of cellulosic biomass results in production of fermentation inhibitors which accumulate in process water and make the water recycle process difficult. Use of MFCs to remove the inhibitory sugar and lignin degradation products from recycle water is investigated in this study. Results Use of an MFC to reduce the levels of furfural, 5-hydroxymethylfurfural, vanillic acid, 4-hydroxybenzaldehyde and 4-hydroxyacetophenone while simultaneously producing electricity is demonstrated here. An integrated MFC design approach was used which resulted in high power densities for the MFC, reaching up to 3700 mW/m2 (356 W/m3 net anode volume and a coulombic efficiency of 69%. The exoelectrogenic microbial consortium enriched in the anode was characterized using a 16S rRNA clone library method. A unique exoelectrogenic microbial consortium dominated by δ-Proteobacteria (50%, along with β-Proteobacteria (28%, α-Proteobacteria (14%, γ-Proteobacteria (6% and others was identified. The consortium demonstrated broad substrate specificity, ability to handle high inhibitor concentrations (5 to 20 mM with near complete removal, while maintaining long-term stability with respect to power production. Conclusion Use of MFCs for removing fermentation inhibitors has implications for: 1 enabling higher ethanol yields at high biomass loading in cellulosic ethanol biorefineries, 2 improved water recycle and 3 electricity production up to 25% of total biorefinery power needs.

  18. Biodiesel biorefinery: opportunities and challenges for microbial production of fuels and chemicals from glycerol waste

    Directory of Open Access Journals (Sweden)

    Almeida João R M

    2012-07-01

    Full Text Available Abstract The considerable increase in biodiesel production worldwide in the last 5 years resulted in a stoichiometric increased coproduction of crude glycerol. As an excess of crude glycerol has been produced, its value on market was reduced and it is becoming a “waste-stream” instead of a valuable “coproduct”. The development of biorefineries, i.e. production of chemicals and power integrated with conversion processes of biomass into biofuels, has been singled out as a way to achieve economically viable production chains, valorize residues and coproducts, and reduce industrial waste disposal. In this sense, several alternatives aimed at the use of crude glycerol to produce fuels and chemicals by microbial fermentation have been evaluated. This review summarizes different strategies employed to produce biofuels and chemicals (1,3-propanediol, 2,3-butanediol, ethanol, n-butanol, organic acids, polyols and others by microbial fermentation of glycerol. Initially, the industrial use of each chemical is briefly presented; then we systematically summarize and discuss the different strategies to produce each chemical, including selection and genetic engineering of producers, and optimization of process conditions to improve yield and productivity. Finally, the impact of the developments obtained until now are placed in perspective and opportunities and challenges for using crude glycerol to the development of biodiesel-based biorefineries are considered. In conclusion, the microbial fermentation of glycerol represents a remarkable alternative to add value to the biodiesel production chain helping the development of biorefineries, which will allow this biofuel to be more competitive.

  19. Integrated fundamental research on current collection

    Science.gov (United States)

    Kuhlmann-Wilsdorf, Doris; Tran, Leo

    1993-06-01

    The aim of our research was to add to the basic understanding in the area of current collection with particular emphasis on topics likely to benefit practical objectives. Under sponsorship of this contract, 23 papers were published in the international literature. Additionally, 13 invited lectures and 11 contributed lectures on various aspects of this research were delivered at universities, research laboratories, and international conferences by the principal investigator and co-workers. The development of a novel metal fiber material for sliding electrical contacts was continued with much success. This is expected to become very useful for making metal fiber brushed for homopolar motors/generators, as well as for EML armatures. Included in this report are title pages (and abstracts) for the 23 published papers.

  20. Perspectives on the production of polyhydroxyalkanoates in biorefineries associated with the production of sugar and ethanol.

    Science.gov (United States)

    Silva, Luiziana Ferreira; Taciro, Marilda Keico; Raicher, Gil; Piccoli, Rosane Aparecida Moniz; Mendonça, Thatiane Teixeira; Lopes, Mateus Schreiner Garcez; Gomez, José Gregório Cabrera

    2014-11-01

    Polyhydroxyalkanoates (PHA) are biodegradable and biocompatible bacterial thermoplastic polymers that can be obtained from renewable resources. The high impact of the carbon source in the final cost of this polymer has been one of the major limiting factors for PHA production and agricultural residues, mainly lignocellulosic materials, have gained attention to overcome this problem. In Brazil, production of 2nd generation ethanol from the glucose fraction, derived from sugarcane bagasse hydrolysate has been studied. The huge amounts of remaining xylose will create an opportunity for the development of other bioprocesses, generating new products to be introduced into a biorefinery model. Although PHA production from sucrose integrated to a 1G ethanol and sugar mill has been proposed in the past, the integration of the process of 2G ethanol in the context of a biorefinery will provide enormous amounts of xylose, which could be applied to produce PHA, establishing a second-generation of PHA production process. Those aspects and perspectives are presented in this article. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Integration of Social Sciences in Nuclear Research

    Energy Technology Data Exchange (ETDEWEB)

    Bovy, M.; Eggermont, G

    2002-04-01

    In 1998, SCK-CEN initiated a programme to integrate social sciences into its scientific and technological projects. Activities were started on the following issues: (1) sustainable development; (2) ethics and decision making in nuclear waste management (transgenerational ethics/retrievability; socio-psychological aspect and local involvement); (3) law and liability (medical applications and the basic safety standards implementation); (4) decision making (emergency management); safety culture; ALARA and ethical choices in protection). Two working groups were created to discuss two broad items: (1) ethical choices in radiation protection; and (2) the role and culture of the expert. Progress and major achievements in SCK-CEN's social science programme in 2001 are summarised.

  2. Integrating Qualitative and Quantitative Research in Organizations.

    Science.gov (United States)

    1981-07-01

    Lofland, lq76), symbolic interactionism (Blumer, 1969), ethnomethodology (Turner, 1974), existentialism (Douglas & Johnson, 1977), and phenomenology...influenced greatly by this ethnomethodology or perhaps symbolic interactionism , many others will have bcen influenced by a variety of the other...approach, qualitatitve research is based on a variety of philosophical orien- tations including natural science, symbolic interactionism , and existential

  3. High school science fair and research integrity

    Science.gov (United States)

    Dalley, Simon; Shepherd, Karen; Reisch, Joan

    2017-01-01

    Research misconduct has become an important matter of concern in the scientific community. The extent to which such behavior occurs early in science education has received little attention. In the current study, using the web-based data collection program REDCap, we obtained responses to an anonymous and voluntary survey about science fair from 65 high school students who recently competed in the Dallas Regional Science and Engineering Fair and from 237 STEM-track, post-high school students (undergraduates, 1st year medical students, and 1st year biomedical graduate students) doing research at UT Southwestern Medical Center. Of the post-high school students, 24% had competed in science fair during their high school education. Science fair experience was similar overall for the local cohort of Dallas regional students and the more diverse state/national cohort of post-high school students. Only one student out of 122 reported research misconduct, in his case making up the data. Unexpectedly, post-high school students who did not participate in science fair anticipated that carrying out science fair would be much more difficult than actually was the case, and 22% of the post-high school students anticipated that science fair participants would resort to research misconduct to overcome obstacles. No gender-based differences between students’ science fair experiences or expectations were evident. PMID:28328976

  4. Integrating Current Meteorological Research Through Club Fundraising

    Science.gov (United States)

    Gill, S. S.; Kauffman, C. M.

    2003-12-01

    Earth science programs whose focus is primarily an undergraduate education do not often have the funding to take students to very many conferences which could expose the student to new research as well as possible graduate programs and employment opportunities. Conferences also give the more enthusiastic and hardworking students a venue in which to present their research to the meteorological community. In addition, the California University services largely lower income counties, which make student attendance at conferences even more difficult even though the student in SW PA may be individually motivated. This issue is compounded by the fact that the Meteorology Concentration within the Earth Science department at Cal U is composed of only two full-time Professors, which limits the amount of research students can be exposed to within a classroom setting. New research ideas presented at conferences are thus an important mechanism for broadening what could be an isolated program. One way in which the meteorology program has circumvented the funding problem to a certain extent is through an active student club. With nearly 60 majors (3/4 of which are active in club activities, the meteorology club is able to execute a variety of fundraising activities. Money that is raised can then request from student services matching funds. Further money is given to clubs, which are very active not only in fundraising, but using that money for academic related activities. For the last 3 years the club budget has been in the neighborhood of \\$4500. The money has then been used to partially finance student registration and accommodation costs making conference attendance much more affordable. Normally 8-16 students attend conferences that they would otherwise not be able to attend without great expense. There are times when more than 16 students wish to attend, but travel arrangements prohibit more than 16. Moreover club money is also use to supplement student costs on a summer

  5. Supply Chain Management and Sustainability: Procrastinating Integration in Mainstream Research

    Directory of Open Access Journals (Sweden)

    Marisa P. de Brito

    2010-03-01

    Full Text Available Research has pointed out opportunities and research agendas to integrate sustainability issues with supply chain and operations management. However, we find that it is still not mainstream practice to systematically take a sustainability approach in tackling supply chain and operations management issues. In this paper, we make use of behavioral theory to explain the current lack of integration. We conclude through abductive reasoning that the reasons for procrastinating integration of sustainability in supply chain and operations management research are the conflicting nature of the task and the inherent context, which is the focus on operations rather than environmental or social issues.

  6. Reactor pressure vessel structural integrity research

    International Nuclear Information System (INIS)

    Pennell, W.E.; Corwin, W.R.

    1994-01-01

    Development continues on the technology used to assess the safety of irradiation-embrittled nuclear reactor pressure vessels (RPVs) containing flaws. Fracture mechanics tests on RPV steel, coupled with detailed elastic-plastic finite-element analyses of the crack-tip stress fields, have shown that (1) constraint relaxation at the crack tip of shallow surface flaws results in increased data scatter but no increase in the lower-bound fracture toughness, (2) the nil ductility temperature (NDT) performs better than the reference temperature for nil ductility transition (RT NDT ) as a normalizing parameter for shallow-flaw fracture toughness data, (3) biaxial loading can reduce the shallow-flaw fracture toughness, (4) stress-based dual-parameter fracture toughness correlations cannot predict the effect of biaxial loading on shallow-flaw fracture toughness because in-plane stresses at the crack tip are not influenced by biaxial loading, and (5) an implicit strain-based dual-parameter fracture toughness correlation can predict the effect of biaxial loading on shallow-flaw fracture toughness. Experimental irradiation investigations have shown that (1) the irradiation-induced shift in Charpy V-notch vs temperature behavior may not be adequate to conservatively assess fracture toughness shifts due to embrittlement, and (2) the wide global variations of initial chemistry and fracture properties of a nominally uniform material within a pressure vessel may confound accurate integrity assessments that require baseline properties

  7. Integrating intersectionality and biomedicine in health disparities research.

    Science.gov (United States)

    Kelly, Ursula A

    2009-01-01

    Persisting health disparities have lead to calls for an increase in health research to address them. Biomedical scientists call for research that stratifies individual indicators associated with health disparities, for example, ethnicity. Feminist social scientists recommend feminist intersectionality research. Intersectionality is the multiplicative effect of inequalities experienced by nondominant marginalized groups, for example, ethnic minorities, women, and the poor. The elimination of health disparities necessitates integration of both paradigms in health research. This study provides a practical application of the integration of biomedical and feminist intersectionality paradigms in nursing research, using a psychiatric intervention study with battered Latino women as an example.

  8. Scientific misconduct and research integrity for the bench scientist.

    Science.gov (United States)

    Pascal, C B

    2000-09-01

    This paper describes the role of the Office of Research Integrity (ORI), a component of the Public Health Service (PHS), in defining scientific misconduct in research supported with PHS funds and in establishing standards for responding to allegations of misconduct. The principal methods by which ORI exercises its responsibilities in this area are defining what types of behaviors undertaken by research investigators constitute misconduct, overseeing institutional efforts to investigate and report misconduct, and recommending to the Assistant Secretary for Health (ASH) PHS administrative actions when misconduct is identified. ORI also takes affirmative steps to promote research integrity through education, training, and other initiatives. The role of the research institution in responding to misconduct and promoting research integrity is complementary and overlapping with ORI's efforts but, as the employer of research investigators and front-line manager of the research, the institution has a greater opportunity to promote the highest standards of integrity in the day-to-day conduct of research. Finally, legal precedent established through civil litigation has played an important role in defining the standards that apply in determining when a breach of research integrity has occurred.

  9. Integral Methodological Pluralism in Science Education Research: Valuing Multiple Perspectives

    Science.gov (United States)

    Davis, Nancy T.; Callihan, Laurie P.

    2013-01-01

    This article examines the multiple methodologies used in educational research and proposes a model that includes all of them as contributing to understanding educational contexts and research from multiple perspectives. The model, based on integral theory (Wilber in a theory of everything. Shambhala, Boston, 2000) values all forms of research as…

  10. A Translational Model of Research-Practice Integration

    Science.gov (United States)

    Vivian, Dina; Hershenberg, Rachel; Teachman, Bethany A.; Drabick, Deborah A. G.; Goldfried, Marvin R.; Wolfe, Barry

    2013-01-01

    We propose a four-level, recursive Research-Practice Integration framework as a heuristic to (a) integrate and reflect on the articles in this Special Section as contributing to a bidirectional bridge between research and practice, and (b) consider additional opportunities to address the research–practice gap. Level 1 addresses Treatment Validation studies and includes an article by Lochman and colleagues concerning the programmatic adaptation, implementation, and dissemination of the empirically supported Coping Power treatment program for youth aggression. Level 2 translation, Training in Evidence-Based Practice, includes a paper by Hershenberg, Drabick, and Vivian, which focuses on the critical role that predoctoral training plays in bridging the research–practice gap. Level 3 addresses the Assessment of Clinical Utility and Feedback to Research aspects of translation. The articles by Lambert and Youn, Kraus, and Castonguay illustrate the use of commercial outcome packages that enable psychotherapists to integrate ongoing client assessment, thus enhancing the effectiveness of treatment implementation and providing data that can be fed back to researchers. Lastly, Level 4 translation, the Cross-Level Integrative Research and Communication, concerns research efforts that integrate data from clinical practice and all other levels of translation, as well as communication efforts among all stakeholders, such as researchers, psychotherapists, and clients. Using a two-chair technique as a framework for his discussion, Wolfe's article depicts the struggle inherent in research–practice integration efforts and proposes a rapprochement that highlights advancements in the field. PMID:22642522

  11. European Research Reloaded : Cooperation and Integration Among Europeanized States

    NARCIS (Netherlands)

    Holzhacker, Ron; Haverland, Markus

    2006-01-01

    European integration has had an ever deepening impact on the member states. The first wave of research concerned the process of institution building and policy developments at the European Union (EU) level. The second wave, on Europeanization used the resulting integration as an explanatory factor

  12. Integrating research with management: The case of Katavi National ...

    African Journals Online (AJOL)

    Integrating research with management: The case of Katavi National Park, Tanzania. ... national park: (i) reduced water flow caused by local damming of the Katuma River, ... to both management and policy makers for tackling these problems.

  13. Development of an integrated data acquision system for research vessels

    Digital Repository Service at National Institute of Oceanography (India)

    Mehra, P.; Desai, R.G.P.

    This article describes an integrated data acquisition system (IDAS) designed and developed for multi-oceanographic research vessels. The prime motivation was to provide a flexible system, which could be used in the context of ocean related...

  14. Considerations for future education in integrative landscape research

    NARCIS (Netherlands)

    Tress, G.; Tress, B.; Fry, G.; Opdam, P.F.M.; Ahern, J.F.; Antrop, M.; Hartig, T.; Hobbs, R.; Miller, D.; Silbernagel, J.M.; Winder, N.

    2006-01-01

    This chapter discusses challenges for PhD students involved in integrative landscape research. These challenges include terminology, epistemology, expectations, stakeholder involvement, organizational barriers, communicating and publishing, as well as career development. The chapter presents

  15. Research Ethics and Commercial Drug Development: When Integrity Threatens Profitability

    Directory of Open Access Journals (Sweden)

    Bélisle Pipon, Jean-Christophe

    2016-05-01

    Full Text Available This case, based on personal experiences and on those found in the literature, highlights the delicate tension faced by drug development companies having to balance research integrity and their profitability.

  16. Panafrican Research Agenda on the Integration of ICTs in Education ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Panafrican Research Agenda on the Integration of ICTs in Education - Phase I ... and communication technologies (ICTs), particularly the Internet, in education ... by taking inventory (policies, infrastructure, teacher training, uses, impact, etc.) ...

  17. Multi-product biorefineries from lignocelluloses: a pathway to revitalisation of the sugar industry?

    Science.gov (United States)

    Farzad, Somayeh; Mandegari, Mohsen Ali; Guo, Miao; Haigh, Kathleen F; Shah, Nilay; Görgens, Johann F

    2017-01-01

    Driven by a range of sustainability challenges, e.g. climate change, resource depletion and expanding populations, a circular bioeconomy is emerging and expected to evolve progressively in the coming decades. South Africa along with other BRICS countries (Brazil, Russia, India and China) represents the emerging bioeconomy and contributes significantly to global sugar market. In our research, South Africa is used as a case study to demonstrate the sustainable design for the future biorefineries annexed to existing sugar industry. Detailed techno-economic evaluation and Life Cycle Assessment (LCA) were applied to model alternative routes for converting sugarcane residues (bagasse and trash) to selected biofuel and/or biochemicals (ethanol, ethanol and lactic acid, ethanol and furfural, butanol, methanol and Fischer-Tropsch synthesis, with co-production of surplus electricity) in an energy self-sufficient biorefinery system. Economic assessment indicated that methanol synthesis with an internal rate of return (IRR) of 16.7% and ethanol-lactic acid co-production (20.5%) met the minimum investment criteria of 15%, while the latter had the lowest sensitivity to market price amongst all the scenarios. LCA results demonstrated that sugarcane cultivation was the most significant contributor to environmental impacts in all of the scenarios, other than the furfural production scenario in which a key step, a biphasic process with tetrahydrofuran solvent, had the most significant contribution. Overall, the thermochemical routes presented environmental advantages over biochemical pathways on most of the impact categories, except for acidification and eutrophication. Of the investigated scenarios, furfural production delivered the inferior environmental performance, while methanol production performed best due to its low reagent consumption. The combined techno-economic and environmental assessments identified the performance-limiting steps in the 2G biorefinery design for

  18. Mediator infrastructure for information integration and semantic data integration environment for biomedical research.

    Science.gov (United States)

    Grethe, Jeffrey S; Ross, Edward; Little, David; Sanders, Brian; Gupta, Amarnath; Astakhov, Vadim

    2009-01-01

    This paper presents current progress in the development of semantic data integration environment which is a part of the Biomedical Informatics Research Network (BIRN; http://www.nbirn.net) project. BIRN is sponsored by the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH). A goal is the development of a cyberinfrastructure for biomedical research that supports advance data acquisition, data storage, data management, data integration, data mining, data visualization, and other computing and information processing services over the Internet. Each participating institution maintains storage of their experimental or computationally derived data. Mediator-based data integration system performs semantic integration over the databases to enable researchers to perform analyses based on larger and broader datasets than would be available from any single institution's data. This paper describes recent revision of the system architecture, implementation, and capabilities of the semantically based data integration environment for BIRN.

  19. Optimal design of a multi-product biorefinery system

    DEFF Research Database (Denmark)

    Zondervan, E.; Nawaz, Mehboob; de Haan, André B.

    2011-01-01

    In this paper we propose a biorefinery optimization model that can be used to find the optimal processing route for the production of ethanol, butanol, succinic acid and blends of these chemicals with fossil fuel based gasoline. The approach unites transshipment models with a superstructure...

  20. Sugar beet leaves: from biorefinery to techno-functionality

    NARCIS (Netherlands)

    Kiskini, Alexandra

    2017-01-01

    Sugar beet leaves (SBL), which are a side stream of the sugar beets cultivation, are currently left unexploited after sugar beets have been harvested. The general aim of this thesis was to study the biorefinery of SBL, with a special focus on the isolation of proteins. To reach this aim the

  1. Catalysis for biorefineries-performance criteria for industrial operation

    NARCIS (Netherlands)

    Lange, Jean Paul

    2016-01-01

    Past analyses of industrial processes for fuel and chemical manufacturing led to a few performance criteria that are critical for viable industrial operation. The present paper reviews these factors and provides a target window for each of them. It then illustrates their relevance for biorefineries

  2. Techno-economical evaluation of protein extraction for microalgae biorefinery

    NARCIS (Netherlands)

    Sari, Y.W.; Sanders, J.P.M.; Bruins, M.

    2016-01-01

    Due to scarcity of fossil feedstocks, there is an increasing demand for biobased fuels. Microalgae are considered as promising biobased feedstocks. However, microalgae based fuels are not yet produced at large scale at present. Applying biorefinery, not only for oil, but also for other

  3. NASA Guidelines for Promoting Scientific and Research Integrity

    Science.gov (United States)

    Kaminski, Amy P.; Neogi, Natasha A.

    2017-01-01

    This guidebook provides an overarching summary of existing policies, activities, and guiding principles for scientific and research integrity with which NASA's workforce and affiliates must conform. This document addresses NASA's obligations as both a research institution and as a funder of research, NASA's use of federal advisory committees, NASA's public communication of research results, and professional development of NASA's workforce. This guidebook is intended to provide a single resource for NASA researchers, NASA research program administrators and project managers, external entities who do or might receive funding from NASA for research or technical projects, evaluators of NASA research proposals, NASA advisory committee members, NASA communications specialists, and members of the general public so that they can understand NASA's commitment to and expectations for scientific and integrity across the agency.

  4. Can We Integrate Qualitative and Quantitative Research in Science Education?

    Science.gov (United States)

    Niaz, Mansoor

    The main objective of this paper is to emphasize the importance of integrating qualitative and quantitative research methodologies in science education. It is argued that the Kuhnian in commensurability thesis (a major source of inspiration for qualitative researchers) represents an obstacle for this integration. A major thesis of the paper is that qualitative researchers have interpreted the increased popularity of their paradigm (research programme) as a revolutionary break through in the Kuhnian sense. A review of the literature in areas relevant to science education shows that researchers are far from advocating qualitative research as the only methodology. It is concluded that competition between divergent approaches to research in science education (cf. Lakatos, 1970) would provide a better forum for a productive sharing of research experiences.

  5. Psychotherapy, psychopathology, research and practice: pathways of connections and integration.

    Science.gov (United States)

    Castonguay, Louis G

    2011-03-01

    This paper describes three pathways of connections between different communities of knowledge seekers: integration of psychotherapeutic approaches, integration of psychotherapy and psychopathology, and integration of science and practice. Some of the issues discussed involve the delineation and investigation of common factors (e.g., principles of change), improvement of major forms of psychotherapy, clinical implications of psychopathology research, as well as current and future directions related to practice-research networks. The aim of this paper is to suggest that building bridges across theoretical orientations, scientific fields, professional experiences, and epistemological views may be a fruitful strategy to improve our understanding and the impact of psychotherapy.

  6. [Phenolic foam prepared by lignin from a steam-explosion derived biorefinery of corn stalk].

    Science.gov (United States)

    Wang, Guanhua; Chen, Hongzhang

    2014-06-01

    To increase the integral economic effectiveness, biorefineries of lignocellulosic materials should not only utilize carbohydrates hydrolyzed from cellulose and hemicellulose but also use lignin. We used steam-exploded corn stalk as raw materials and optimized the temperature and alkali concentration in the lignin extraction process to obtain lignin liquor with higher yield and purity. Then the concentrated lignin liquor was used directly to substitute phenol for phenolic foam preparation and the performances of phenolic foam were characterized by microscopic structure analysis, FTIR, compression strength and thermal conductivity detection. The results indicated that, when steam-exploded corn stalk was extracted at 120 degrees C for 2 h by 1% NaOH with a solid to liquid ratio of 1:10, the extraction yield of lignin was 79.67%. The phenolic foam prepared from the concentrated lignin liquor showed higher apparent density and compression strength with the increasing substitution rate of lignin liquor. However, there were not significant differences of thermal conductivity and flame retardant properties by the addition of lignin, which meant that the phenolic foam substituted by lignin liquor was approved for commercial application. This study, which uses alkali-extracted lignin liquor directly for phenolic foam preparation, provides a relatively simple way for utilization of lignin and finally increases the overall commercial operability ofa lignocellulosic biorefinery derived by steam explosion.

  7. Critical analysis of emerging forest biorefinery (FBR) technologies for ethanol production

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, J.; Janssen, M.; Chambost, V.; Stuart, P. [Ecole Polytechnique, Montreal, PQ (Canada). Dept. de Genie Chimique. Design Engineering Chair in Process Integration

    2010-05-15

    This article provided a literature review of emerging technologies for ethanol production in Canada. A multi-criteria decision making (MCDM) panel was used to weigh critical metrics for evaluating the potential of emerging forest biorefinery technologies for bio-ethanol production. The 3-step methodology identified key factors for evaluating technology pathways. Key factors were applied to a group of selected technologies in order to collect data. All previous criteria were weighted through the MCDM panel in order to rank the technologies, which included biochemical pathway and thermochemical pathway production processes. Criteria included return on investment; feedstock flexibility; technology risk; energy and integration; products and revenue diversification; potential for additional products; and potential environmental impact. The study showed that techno-economic criteria are the most important barriers to the implementation of ethanol biorefineries. While thermochemical processes are economically feasible and provide greater flexibility, biochemical refining processes may provide for the development of other value-added products. 21 refs., 3 tabs., 7 figs.

  8. Critical analysis of emerging forest biorefinery (FBR) technologies for ethanol production

    International Nuclear Information System (INIS)

    Cohen, J.; Janssen, M.; Chambost, V.; Stuart, P.

    2010-01-01

    This article provided a literature review of emerging technologies for ethanol production in Canada. A multi-criteria decision making (MCDM) panel was used to weigh critical metrics for evaluating the potential of emerging forest biorefinery technologies for bio-ethanol production. The 3-step methodology identified key factors for evaluating technology pathways. Key factors were applied to a group of selected technologies in order to collect data. All previous criteria were weighted through the MCDM panel in order to rank the technologies, which included biochemical pathway and thermochemical pathway production processes. Criteria included return on investment; feedstock flexibility; technology risk; energy and integration; products and revenue diversification; potential for additional products; and potential environmental impact. The study showed that techno-economic criteria are the most important barriers to the implementation of ethanol biorefineries. While thermochemical processes are economically feasible and provide greater flexibility, biochemical refining processes may provide for the development of other value-added products. 21 refs., 3 tabs., 7 figs.

  9. Sustainable and Efficient Pathways for Bioenergy Recovery from Low-Value Process Streams via Bioelectrochemical Systems in Biorefineries

    Directory of Open Access Journals (Sweden)

    Abhijeet P. Borole

    2015-08-01

    Full Text Available Conversion of biomass into bioenergy is possible via multiple pathways resulting in the production of biofuels, bioproducts, and biopower. Efficient and sustainable conversion of biomass, however, requires consideration of many environmental and societal parameters in order to minimize negative impacts. Integration of multiple conversion technologies and inclusion of upcoming alternatives, such as bioelectrochemical systems, can minimize these impacts via production of hydrogen, electricity or other forms of energy from the low value streams and improve conservation of resources, such as water and nutrients via recycle and reuse. This report outlines alternate pathways integrating microbial electrolysis in biorefinery schemes to improve energy efficiency, while evaluating environmental sustainability parameters.

  10. BER-Myriant Succinic Acid Biorefinery

    Energy Technology Data Exchange (ETDEWEB)

    Shmorhun, Mark [Myriant Lake Providence, Inc., Lake Providence, LA (United States)

    2015-12-31

    Myriant Corporation (Myriant) has successfully produced the bioproduct succinic acid by the fermentation of glucose at a commercial scale operation in Lake Providence, Louisiana. The MySAB facility (Myriant Succinic Acid Biorefinery) came on stream in May 2013 and has been producing product since then. The MySAB facility is a demonstration-scale plant, capable of utilizing sorghum grits and commercially available dextrose, to ferment glucose into succinic acid. A downstream processing train has demonstrated the ability to produce an industrial, a standard and a polymer grade product. It consists of cell separation, membrane filtration, continuous chromatography, polishing to remove ionic and color bodies impurities, and final evaporation and crystallization. A by-product of the process is ammonium sulfate which is sold as a liquid fertilizer product. Since 2007 when development work began in the Woburn, Massachusetts R&D laboratories, the succinic acid bio-process has evolved through: Process development (microbiology, fermentation, and downstream) – R&D development laboratories; Piloting efforts at Fermic S.A. de C.V., Mexico City, Mexico – upstream and downstream processes; Design, construction, commissioning, and commercial production operations at the MySAB facility Additionally, Myriant became a wholly-owned subsidiary of the PTT Global Chemical Plc., Thailand, in late 2015, their investment into and support of Myriant goes back to 2011. The support of PTT Global Chemical Plc. helped to improve the upstream and downstream processes, and produce significant metric ton quantities of high quality bio-based succinic acid. The product has gone into a number of commercial markets worldwide for customer applications, development and production. The experience base gained via operations at the MySAB facility since May 2013, along with continued R&D development efforts involving Microbiology, Fermentation, and Downstream processes, at both the Woburn, Massachusetts

  11. The Role of Integrated Knowledge Translation in Intervention Research.

    Science.gov (United States)

    Wathen, C Nadine; MacMillan, Harriet L

    2018-04-01

    There is widespread recognition across the full range of applied research disciplines, including health and social services, about the challenges of integrating scientifically derived research evidence into policy and/or practice decisions. These "disconnects" or "knowledge-practice gaps" between research production and use have spawned a new research field, most commonly known as either "implementation science" or "knowledge translation." The present paper will review key concepts in this area, with a particular focus on "integrated knowledge translation" (IKT)-which focuses on researcher-knowledge user partnership-in the area of mental health and prevention of violence against women and children using case examples from completed and ongoing work. A key distinction is made between the practice of KT (disseminating, communicating, etc.), and the science of KT, i.e., research regarding effective KT approaches. We conclude with a discussion of the relevance of IKT for mental health intervention research with children and adolescents.

  12. Working with Research Integrity-Guidance for Research Performing Organisations: The Bonn PRINTEGER Statement.

    Science.gov (United States)

    Forsberg, Ellen-Marie; Anthun, Frank O; Bailey, Sharon; Birchley, Giles; Bout, Henriette; Casonato, Carlo; Fuster, Gloria González; Heinrichs, Bert; Horbach, Serge; Jacobsen, Ingrid Skjæggestad; Janssen, Jacques; Kaiser, Matthias; Lerouge, Inge; van der Meulen, Barend; de Rijcke, Sarah; Saretzki, Thomas; Sutrop, Margit; Tazewell, Marta; Varantola, Krista; Vie, Knut Jørgen; Zwart, Hub; Zöller, Mira

    2018-05-31

    This document presents the Bonn PRINTEGER Consensus Statement: Working with Research Integrity-Guidance for research performing organisations. The aim of the statement is to complement existing instruments by focusing specifically on institutional responsibilities for strengthening integrity. It takes into account the daily challenges and organisational contexts of most researchers. The statement intends to make research integrity challenges recognisable from the work-floor perspective, providing concrete advice on organisational measures to strengthen integrity. The statement, which was concluded February 7th 2018, provides guidance on the following key issues: § 1. Providing information about research integrity § 2. Providing education, training and mentoring § 3. Strengthening a research integrity culture § 4. Facilitating open dialogue § 5. Wise incentive management § 6. Implementing quality assurance procedures § 7. Improving the work environment and work satisfaction § 8. Increasing transparency of misconduct cases § 9. Opening up research § 10. Implementing safe and effective whistle-blowing channels § 11. Protecting the alleged perpetrators § 12. Establishing a research integrity committee and appointing an ombudsperson § 13. Making explicit the applicable standards for research integrity.

  13. Trends and Features of Student Research Integration in Educational Program

    Science.gov (United States)

    Grinenko, Svetlana; Makarova, Elena; Andreassen, John-Erik

    2016-01-01

    This study examines trends and features of student research integration in educational program during international cooperation between Østfold University College in Norway and Southern Federal University in Russia. According to research and education approach the international project is aimed to use four education models, which linked student…

  14. Supply Chain Management and Sustainability: Procrastinating Integration in Mainstream Research

    NARCIS (Netherlands)

    M.P. de Brito (Marisa); E.A. van der Laan (Erwin)

    2010-01-01

    textabstractResearch has pointed out opportunities and research agendas to integrate sustainability issues with supply chain and operations management. However, we find that it is still not mainstream practice to systematically take a sustainability approach in tackling supply chain and operations

  15. Supply Chain Management and Sustainability : Procrastinating Integration in Mainstream Research

    NARCIS (Netherlands)

    De Brito, M.P.; Van der Laan, E.A.

    2010-01-01

    Research has pointed out opportunities and research agendas to integrate sustainability issues with supply chain and operations management. However, we find that it is still not mainstream practice to systematically take a sustainability approach in tackling supply chain and operations management

  16. Connecting Practice and Research: Integrated Reading and Writing Instruction Assessment

    Science.gov (United States)

    Caverly, David C.; Taylor, Judi Salsburg; Dimino, Renee K.; Lampi, Jodi P.

    2016-01-01

    The first "Connecting Practice and Research" column (Lampi, Dimino, & Salsburg Taylor, 2015), introduced a Research-to-Practice partnership (Coburn & Penuel, 2016) between two faculty from a community college and a university professor who were aiming to develop effective integrated reading and writing (IRW) instruction through a…

  17. TEAM 1 Integrated Research Partnerships for Malaria Control ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC CRDI

    TEAM 1 Integrated Research Partnerships for Malaria Control through an Ecohealth Approach in. East Africa. Abstract: Representing East Africa, the National Institute for Medical Research (NIMR, Tanzania), icipe, the. Kigali Health Institute (Rwanda) and the Kamuli local government district authority in Uganda form.

  18. Brazilian Science and Research Integrity: Where are We? What Next?

    Directory of Open Access Journals (Sweden)

    Sonia M.R. Vasconcelos

    2015-06-01

    Full Text Available Building a world-class scientific community requires first-class ingredients at many different levels: funding, training, management, international collaborations, creativity, ethics, and an understanding of research integrity practices. All over the world, addressing these practices has been high on the science policy agenda of major research systems. Universities have a central role in fostering a culture of research integrity, which has posed additional challenges for faculty, students and administrators - but also opportunities. In Brazil, the leading universities and governmental funding agencies are collaborating on this project, but much remains to be done.

  19. Brazilian Science and Research Integrity: Where are We? What Next?

    Science.gov (United States)

    Vasconcelos, Sonia M R; Sorenson, Martha M; Watanabe, Edson H; Foguel, Debora; Palácios, Marisa

    2015-01-01

    Building a world-class scientific community requires first-class ingredients at many different levels: funding, training, management, international collaborations, creativity, ethics, and an understanding of research integrity practices. All over the world, addressing these practices has been high on the science policy agenda of major research systems. Universities have a central role in fostering a culture of research integrity, which has posed additional challenges for faculty, students and administrators - but also opportunities. In Brazil, the leading universities and governmental funding agencies are collaborating on this project, but much remains to be done.

  20. Barriers to Implementing Treatment Integrity Procedures in School Psychology Research: Survey of Treatment Outcome Researchers

    Science.gov (United States)

    Sanetti, Lisa M. Hagermoser; DiGennaro Reed, Florence D.

    2012-01-01

    Treatment integrity data are essential to drawing valid conclusions in treatment outcome studies. Such data, however, are not always included in peer-reviewed research articles in school psychology or related fields. To gain a better understanding of why treatment integrity data are lacking in the school psychology research, we surveyed the…

  1. Integration of clinical research documentation in electronic health records.

    Science.gov (United States)

    Broach, Debra

    2015-04-01

    Clinical trials of investigational drugs and devices are often conducted within healthcare facilities concurrently with clinical care. With implementation of electronic health records, new communication methods are required to notify nonresearch clinicians of research participation. This article reviews clinical research source documentation, the electronic health record and the medical record, areas in which the research record and electronic health record overlap, and implications for the research nurse coordinator in documentation of the care of the patient/subject. Incorporation of clinical research documentation in the electronic health record will lead to a more complete patient/subject medical record in compliance with both research and medical records regulations. A literature search provided little information about the inclusion of clinical research documentation within the electronic health record. Although regulations and guidelines define both source documentation and the medical record, integration of research documentation in the electronic health record is not clearly defined. At minimum, the signed informed consent(s), investigational drug or device usage, and research team contact information should be documented within the electronic health record. Institutional policies should define a standardized process for this integration in the absence federal guidance. Nurses coordinating clinical trials are in an ideal position to define this integration.

  2. The GEOSS solution for enabling data interoperability and integrative research.

    Science.gov (United States)

    Nativi, Stefano; Mazzetti, Paolo; Craglia, Max; Pirrone, Nicola

    2014-03-01

    Global sustainability research requires an integrative research effort underpinned by digital infrastructures (systems) able to harness data and heterogeneous information across disciplines. Digital data and information sharing across systems and applications is achieved by implementing interoperability: a property of a product or system to work with other products or systems, present or future. There are at least three main interoperability challenges a digital infrastructure must address: technological, semantic, and organizational. In recent years, important international programs and initiatives are focusing on such an ambitious objective. This manuscript presents and combines the studies and the experiences carried out by three relevant projects, focusing on the heavy metal domain: Global Mercury Observation System, Global Earth Observation System of Systems (GEOSS), and INSPIRE. This research work recognized a valuable interoperability service bus (i.e., a set of standards models, interfaces, and good practices) proposed to characterize the integrative research cyber-infrastructure of the heavy metal research community. In the paper, the GEOSS common infrastructure is discussed implementing a multidisciplinary and participatory research infrastructure, introducing a possible roadmap for the heavy metal pollution research community to join GEOSS as a new Group on Earth Observation community of practice and develop a research infrastructure for carrying out integrative research in its specific domain.

  3. Recent trends on techno-economic assessment (TEA of sugarcane biorefineries

    Directory of Open Access Journals (Sweden)

    Mohsen Ali Mandegari

    2017-09-01

    Full Text Available Sustainability challenges, e.g., climate change, resource depletion, and expanding populations, have triggered a swift move towards a circular bio-economy which is expected to evolve progressively in the coming decades. However, the transition from a fossil fuel-based economy to a bio-based economy requires the exploitation of scientific innovations and step changes in the infrastructure of chemical industry. Biorefineries have been extensively investigated for biofuel production from first and second generation feedstocks, whereas some research activities have been conducted on production of biochemical and biopolymers from renewable resources. Techno-economic evaluation of diverse technologies for production of biofuels and biochemical is a crucial step for decision making in the development of bio-economy. This contribution focuses on the economic studies carried out on biorefineries converting sugarcane bagasse, due to its availability and importance in the South African context, into value-added products. Recent studies on biofuel production via biochemical pathway, e.g., ethanol, butanol, or thermochemical pathway, e.g., methanol and bio jet fuel as well as production of biochemicals with high market demands and diverse applications such as lactic acid, succinic acid, and xylitol have been briefly reviewed. In addition, an overview on the production of biopolymers such as polyl-lactic acid and bio-based monomers, i.e., butanediol, from sugarcane bagasse is reported.

  4. Methods in Entrepreneurship Education Research: A Review and Integrative Framework

    DEFF Research Database (Denmark)

    Blenker, Per; Trolle Elmholdt, Stine; Frederiksen, Signe Hedeboe

    2014-01-01

    is fragmented both conceptually and methodologically. Findings suggest that the methods applied in entrepreneurship education research cluster in two groups: 1. quantitative studies of the extent and effect of entrepreneurship education, and 2. qualitative single case studies of different courses and programmes....... It integrates qualitative and quantitative techniques, the use of research teams consisting of insiders (teachers studying their own teaching) and outsiders (research collaborators studying the education) as well as multiple types of data. To gain both in-depth and analytically generalizable studies...... a variety of helpful methods, explore the potential relation between insiders and outsiders in the research process, and discuss how different types of data can be combined. The integrated framework urges researchers to extend investments in methodological efforts and to enhance the in-depth understanding...

  5. 2011 Biomass Program Platform Peer Review. Integrated Biorefineries

    Energy Technology Data Exchange (ETDEWEB)

    Rossmeissl, Neil [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2012-02-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the 2011 U.S. Department of Energy Biomass Program’s IBR Platform Review meeting.

  6. Integrating Ecological and Social Knowledge: Learning from CHANS Research

    Directory of Open Access Journals (Sweden)

    Bruce Shindler

    2017-03-01

    Full Text Available Scientists are increasingly called upon to integrate across ecological and social disciplines to tackle complex coupled human and natural system (CHANS problems. Integration of these disciplines is challenging and many scientists do not have experience with large integrated research projects. However, much can be learned about the complicated process of integration from such efforts. We document some of these lessons from a National Science Foundation-funded CHANS project (Forests, People, Fire and present considerations for developing and engaging in coupled human and natural system projects. Certainly we are not the first to undertake this endeavor, and many of our findings complement those of other research teams. We focus here on the process of coming together, learning to work as an integrated science team, and describe the challenges and opportunities of engaging stakeholders (agency personnel and citizen communities of interests in our efforts. Throughout this project our intention was to foster dialogue among diverse interests and, thus, incorporate this knowledge into uncovering primary social and ecological drivers of change. A primary tool was an agent-based model, Envision, that used this information in landscape simulation, visualization models, and scenario development. Although integration can be an end in itself, the proof of value in the approach can be the degree to which it provides new insights or tools to CHANS, including closer interaction among multiple stakeholders, that could not have been reached without it.

  7. Integrative Mental Health (IMH): paradigm, research, and clinical practice.

    Science.gov (United States)

    Lake, James; Helgason, Chanel; Sarris, Jerome

    2012-01-01

    This paper provides an overview of the rapidly evolving paradigm of "Integrative Mental Health (IMH)." The paradigm of contemporary biomedical psychiatry and its contrast to non-allopathic systems of medicine is initially reviewed, followed by an exploration of the emerging paradigm of IMH, which aims to reconcile the bio-psycho-socio-spiritual model with evidence-based methods from traditional healing practices. IMH is rapidly transforming conventional understandings of mental illness and has significant positive implications for the day-to-day practice of mental health care. IMH incorporates mainstream interventions such as pharmacologic treatments, psychotherapy, and psychosocial interventions, as well as alternative therapies such as acupuncture, herbal and nutritional medicine, dietary modification, meditation, etc. Two recent international conferences in Europe and the United States show that interest in integrative mental health care is growing rapidly. In response, the International Network of Integrative Mental Health (INIMH: www.INIMH.org) was established in 2010 with the objective of creating an international network of clinicians, researchers, and public health advocates to advance a global agenda for research, education, and clinical practice of evidence-based integrative mental health care. The paper concludes with a discussion of emerging opportunities for research in IMH, and an exploration of potential clinical applications of integrative mental health care. Copyright © 2012 Elsevier Inc. All rights reserved.

  8. Multi-Product Microalgae Biorefineries: From Concept Towards Reality.

    Science.gov (United States)

    't Lam, G P; Vermuë, M H; Eppink, M H M; Wijffels, R H; van den Berg, C

    2018-02-01

    Although microalgae are a promising biobased feedstock, industrial scale production is still far off. To enhance the economic viability of large-scale microalgae processes, all biomass components need to be valorized, requiring a multi-product biorefinery. However, this concept is still too expensive. Typically, downstream processing of industrial biotechnological bulk products accounts for 20-40% of the total production costs, while for a microalgae multi-product biorefinery the costs are substantially higher (50-60%). These costs are high due to the lack of appropriate and mild technologies to access the different product fractions such as proteins, carbohydrates, and lipids. To reduce the costs, simplified processes need to be developed for the main unit operations including harvesting, cell disruption, extraction, and possibly fractionation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Bio-refinery approach for spent coffee grounds valorization.

    Science.gov (United States)

    Mata, Teresa M; Martins, António A; Caetano, Nídia S

    2018-01-01

    Although normally seen as a problem, current policies and strategic plans concur that if adequately managed, waste can be a source of the most interesting and valuable products, among which metals, oils and fats, lignin, cellulose and hemicelluloses, tannins, antioxidants, caffeine, polyphenols, pigments, flavonoids, through recycling, compound recovery or energy valorization, following the waste hierarchy. Besides contributing to more sustainable and circular economies, those products also have high commercial value when compared to the ones obtained by currently used waste treatment methods. In this paper, it is shown how the bio-refinery framework can be used to obtain high value products from organic waste. With spent coffee grounds as a case study, a sequential process is used to obtain first the most valuable, and then other products, allowing proper valorization of residues and increased sustainability of the whole process. Challenges facing full development and implementation of waste based bio-refineries are highlighted. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Algal Biomass for Bioenergy and Bioproducts Production in Biorefinery Concepts

    DEFF Research Database (Denmark)

    D'Este, Martina

    industry. The macroalgae used in this work were Laminaria digitata and Saccharina latissima, while the microalgae were Chlorella sorokiniana, Chlorella vulgaris and Chlorella protothecoides. Moreover, an evaluation of the effect of the harvesting season and location on the composition of high value...... feedstocks. Biorefinery represents an important tool towards the development of a sustainable economy. Within the biorefinery framework several bioproducts, such as food, feed and biofuels, can be produced from biomass. The specific composition of the biomass feedstock determines the potential final product...... heterotrophically in the macroalgae L. digitata hydrolyzed. The final composition of the microalgal biomass showed that the protein content was increased from 0.07 ± 0.01 gProtein gDM-1 to 0.44 ± 0.04 gProtein DM-1. The results obtained show that this solution may represent an interesting strategy to be applied...

  11. BIOREFINERIES – NEW GREEN STRATEGY FOR DEVELOPMENT OF SMART AND INNOVATIVE INDUSTRY

    Directory of Open Access Journals (Sweden)

    Grażyna A. PŁAZA

    2016-07-01

    Full Text Available Ecological engineering or ecotechnology is defined as the design of sustainable production that integrate human society with the natural environment for the benefit of both. In order to reach the goal of sustainability therefore important that bioproduct production systems are converted from to natural cycle oriented. In natural cycles there are not waste, but products are generated at different stages of the cycle. The ecotechnology creates a sustainable bioeconomy using biomass in a smart and efficient way. The biorefining sector, which uses smart, innovative and efficient technologies to convert biomass feedstocks into a range of bio-based products including fuels, chemicals, power, food, and renewable oils, currently presents the innovative and efficient bio-based production can revitalize existing industries. The paper presents the concept of biorefinery as the ecotechnological approach for creating a sustainable bioeconomy using biomass in a smart and efficient way.

  12. Biorefineries - New Green Strategy For Development Of Smart And Innovative Industry

    Science.gov (United States)

    Płaza, Grażyna A.; Wandzich, Dorota

    2016-09-01

    Ecological engineering or ecotechnology is defined as the design of sustainable production that integrate human society with the natural environment for the benefit of both. In order to reach the goal of sustainability therefore important that bioproduct production systems are converted from to natural cycle oriented. In natural cycles there are not waste, but products are generated at different stages of the cycle. The ecotechnology creates a sustainable bioeconomy using biomass in a smart and efficient way. The biorefining sector, which uses smart, innovative and efficient technologies to convert biomass feedstocks into a range of bio-based products including fuels, chemicals, power, food, and renewable oils, currently presents the innovative and efficient bio-based production can revitalize existing industries. The paper presents the concept of biorefinery as the ecotechnological approach for creating a sustainable bioeconomy using biomass in a smart and efficient way.

  13. Chapter 17: Adding Value to the Biorefinery with Lignin: An Engineer's Perspective

    Energy Technology Data Exchange (ETDEWEB)

    Biddy, Mary J [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2018-04-03

    There is a long-standing belief that 'you can make anything out of lignin...except money.' This chapter serves to highlight that opportunities for making money from biomass-derived lignin exist both with current technology in the production of steam and power to new emerging areas of R&D focused on value-added chemical and material coproducts from lignin. To understand and quantify the economic potential for lignin valorization, the techno-economic analysis methodology is first described in detail. As demonstrated in the provided case study, these types of economic evaluations serve not only to estimate the economic impacts that lignin conversion could have for an integrated biorefinery and outline drivers for further cost reduction but also identify data gaps and R&D needs for improving the design basis and reducing the risk for process scale-up.

  14. Biorefineries: Relocating Biomass Refineries to the Rural Area

    Directory of Open Access Journals (Sweden)

    Franka Papendiek

    2012-07-01

    Full Text Available The field for application of biomass is rising. The demand for food and feeding stuff rises while at the same time energy, chemicals and other materials also need to be produced from biomass because of decreasing fossil resources. However, the biorefinery ideas and concepts can help to use the limited renewable raw materials more efficiently than today. With biorefineries, valuable products, such as platform chemicals, can be produced from agricultural feedstock, which can subsequently be further processed into a variety of substances by the chemical industry. Due to the role they play as producers of biomass, rural areas will grow in importance in the decades to come. Parts of the biorefinery process can be relocated to the rural areas to bring a high added value to these regions. By refining biomass at the place of production, new economic opportunities may arise for agriculturists, and the industry gets high-grade pre-products. Additionally, an on-farm refining can increase the quality of the products because of the instant processing. To reduce competition with the food production and to find new possibilities of utilisation for these habitats, the focus for new agricultural biomass should be on grasslands. But also croplands can provide more renewable raw materials without endangering a sustainable agriculture, e.g. by implementing legumes in the crop rotation. To decide if a region can provide adequate amounts of raw material for a biorefinery, new raw material assessment procedures have to be developed. In doing so, involvement of farmers is inevitable to generate a reliable study of the biomass refinery potentials.

  15. Integration and Physical Education: A Review of Research

    Science.gov (United States)

    Marttinen, Risto Harri Juhani; McLoughlin, Gabriella; Fredrick, Ray, III; Novak, Dario

    2017-01-01

    The Common Core State Standards Initiative has placed an increased focus on mathematics and English language arts. A relationship between physical activity and academic achievement is evident, but research on integration of academic subjects with physical education is still unclear. This literature review examined databases for the years…

  16. Advantages of Integrative Data Analysis for Developmental Research

    Science.gov (United States)

    Bainter, Sierra A.; Curran, Patrick J.

    2015-01-01

    Amid recent progress in cognitive development research, high-quality data resources are accumulating, and data sharing and secondary data analysis are becoming increasingly valuable tools. Integrative data analysis (IDA) is an exciting analytical framework that can enhance secondary data analysis in powerful ways. IDA pools item-level data across…

  17. An Integrated Approach to Research Methods and Capstone

    Science.gov (United States)

    Postic, Robert; McCandless, Ray; Stewart, Beth

    2014-01-01

    In 1991, the AACU issued a report on improving undergraduate education suggesting, in part, that a curriculum should be both comprehensive and cohesive. Since 2008, we have systematically integrated our research methods course with our capstone course in an attempt to accomplish the twin goals of comprehensiveness and cohesion. By taking this…

  18. Integrating research into teaching: Needs assessment for staff ...

    African Journals Online (AJOL)

    Background. The scholarship of teaching involves the integration of research into teaching activities, critical reflection of practice, and communication, and dissemination of the practice of one's subject. However, it is not clear what the needs of academics in the Faculty of Community and Health Sciences at the University of ...

  19. Where's the LGBT in integrated care research? A systematic review.

    Science.gov (United States)

    Hughes, Rachel L; Damin, Catherine; Heiden-Rootes, Katie

    2017-09-01

    Lesbian, gay, bisexual, and transgender (LGBT) individuals experience more negative health outcomes compared with their heterosexual peers. The health disparities are often related to family and social rejection of the LGBT individuals. Integrated care, and Medical Family Therapy in particular, may aid in addressing the systemic nature of the negative health outcomes. To better understand the current state of the integrated care literature on addressing the health needs of LGBT individuals, a systematic review of the research literature was conducted from January 2000 to January 2016 for articles including integrated health care interventions for LGBT populations. Independent reviewers coded identified articles. Only 8 research articles met criteria for inclusion out of the 2,553 initially identified articles in the search. Results indicated a lack of integrated care research on health care and health needs of LGBT individuals, and none of the articles addressed the use of family or systemic-level interventions. Implications for future research and the need for better education training are discussed. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  20. Panafrican Research Agenda on the Integration of ICTs in Education ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    PanAf Edu : newsletter of the Panafrican research agenda on the pedagogical integration of ICTs; year 1, no. 1, September 2007. Documents. PanAf Edu : bulletin d'information de l'Agenda panafricain de recherche sur l'intégration pédagogique des TIC; no. 2, janvier 2008. Documents. PanAf Edu : newsletter of the ...

  1. Panafrican Research Agenda on the Integration of ICTs in Education ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Rapports. Qualité de l'enseignement et de l'apprentissage sur ordinateur dans les écoles sénégalaises. Rapports. Ready to change gears? an analysis of how issues of concern influences lecturers rate of adoption of e-learning. Rapports. PanAfrican research agenda on the pedagogical integration of ICTs. Rapports.

  2. Handbook of Research on Innovative Technology Integration in Higher Education

    Science.gov (United States)

    Nafukho, Fredrick Muyia, Ed.; Irby, Beverly J., Ed.

    2015-01-01

    Our increasingly globalized world is driven by shared knowledge, and nowhere is that knowledge more important than in education. Now more than ever, there is a demand for technology that will assist in the spread of knowledge through customized, self-paced, and on-demand learning. The Handbook of Research on Innovative Technology Integration in…

  3. Hawaii Integrated Biofuels Research Program: Final Subcontract Report, Phase III

    Energy Technology Data Exchange (ETDEWEB)

    1992-05-01

    This report is a compilation of studies done to develop an integrated set of strategies for the production of energy from renewable resources in Hawaii. Because of the close coordination between this program and other ongoing DOE research, the work will have broad-based applicability to the entire United States.

  4. Drivers and barriers for implementation of the biorefinery

    International Nuclear Information System (INIS)

    Janssen, M.; Stuart, P.

    2010-01-01

    This paper discussed the barriers and drivers for the implementation of biorefinery technology in the forestry industry. A multi-criteria decision making (MCDM) methodology was used by a panel of industry experts. The objective, drivers and barriers, and the decision structure and weighting procedure were established during a pre-panel phase. An analytic hierarchy process (AHP) was then applied to compare qualitative criteria. Pair-wise criteria were used to determine the importance of each driver and barrier. Drivers for the implementation of biorefineries included the opportunity to ensure short-term profitability; the provision of raw materials at competitive prices; potential financial incentives; and the opportunity to transform the forestry business model and increase its market value. Barriers included uncertainty in relation to government policies for biorefineries; high technology risks; the need for partnerships; and the fact that many industry members favour short-term decision-making. Results of the study showed that the most significant barrier was related to risk. 5 refs., 3 tabs., 3 figs.

  5. Development of an Energy Biorefinery Model for Chestnut (Castanea sativa Mill. Shells

    Directory of Open Access Journals (Sweden)

    Alessandra Morana

    2017-09-01

    Full Text Available Chestnut shells (CS are an agronomic waste generated from the peeling process of the chestnut fruit, which contain 2.7–5.2% (w/w phenolic compounds and approximately 36% (w/w polysaccharides. In contrast with current shell waste burning practices, this study proposes a CS biorefinery that integrates biomass pretreatment, recovery of bioactive molecules, and bioconversion of the lignocellulosic hydrolyzate, while optimizing materials reuse. The CS delignification and saccharification produced a crude hydrolyzate with 12.9 g/L of glucose and xylose, and 682 mg/L of gallic acid equivalents. The detoxification of the crude CS hydrolyzate with 5% (w/v activated charcoal (AC and repeated adsorption, desorption and AC reuse enabled 70.3% (w/w of phenolic compounds recovery, whilst simultaneously retaining the soluble sugars in the detoxified hydrolyzate. The phenols radical scavenging activity (RSA of the first AC eluate reached 51.8 ± 1.6%, which is significantly higher than that of the crude CS hydrolyzate (21.0 ± 1.1%. The fermentation of the detoxified hydrolyzate by C. butyricum produced 10.7 ± 0.2 mM butyrate and 63.9 mL H2/g of CS. Based on the obtained results, the CS biorefinery integrating two energy products (H2 and calorific power from spent CS, two bioproducts (phenolic compounds and butyrate and one material reuse (AC reuse constitutes a valuable upgrading approach for this yet unexploited waste biomass.

  6. Stakeholder integrated research (STIR): a new approach tested in climate change adaptation research

    NARCIS (Netherlands)

    Gramberger, M.; Zellmer, K.; Kok, K.; Metzger, M.J.

    2015-01-01

    Ensuring active participation of stakeholders in scientific projects faces many challenges. These range from adequately selecting stakeholders, overcoming stakeholder fatigue, and dealing with the limited time available for stakeholder engagement, to interacting with, and integrating, the research

  7. Promoting Ethics and Integrity in Management Academic Research: Retraction Initiative.

    Science.gov (United States)

    Ayodele, Freida Ozavize; Yao, Liu; Haron, Hasnah

    2018-02-13

    In the management academic research, academic advancement, job security, and the securing of research funds at one's university are judged mainly by one's output of publications in high impact journals. With bogus resumes filled with published journal articles, universities and other allied institutions are keen to recruit or sustain the appointment of such academics. This often places undue pressure on aspiring academics and on those already recruited to engage in research misconduct which often leads to research integrity. This structured review focuses on the ethics and integrity of management research through an analysis of retracted articles published from 2005 to 2016. The study employs a structured literature review methodology whereby retracted articles published between 2005 and 2016 in the field of management science were found using Crossref and Google Scholar. The searched articles were then streamlined by selecting articles based on their relevance and content in accordance with the inclusion criteria. Based on the analysed retracted articles, the study shows evidence of ethical misconduct among researchers of management science. Such misconduct includes data falsification, the duplication of submitted articles, plagiarism, data irregularity and incomplete citation practices. Interestingly, the analysed results indicate that the field of knowledge management includes the highest number of retracted articles, with plagiarism constituting the most significant ethical issue. Furthermore, the findings of this study show that ethical misconduct is not restricted to a particular geographic location; it occurs in numerous countries. In turn, avenues of further study on research misconduct in management research are proposed.

  8. Report Focuses on Integrity and Accessibility of Research Data

    Science.gov (United States)

    Showstack, Randy

    2009-08-01

    Rapid advances in digital technologies and enormous increases in the amount of data generated by research projects and a variety of instruments and sensors are providing new research opportunities. These advances, however, also can present challenges for ensuring that digital technologies are not used inappropriately and for managing an increasing amount of data, according to a new report issued by the U.S. National Academy of Sciences, National Academy of Engineering, and Institute of Medicine on 22 July. The new report, entitled “Ensuring the integrity, accessibility, and stewardship of research data in the digital age,” provides general principles and recommendations about the handling of research data. The report notes that the development of policies, standards, and infrastructure “is a critically important task” that will require a sustained effort from stakeholders including researchers, research institutions and sponsors, and professional societies and journals.

  9. Utilizing an integrated infrastructure for outcomes research: a systematic review.

    Science.gov (United States)

    Dixon, Brian E; Whipple, Elizabeth C; Lajiness, John M; Murray, Michael D

    2016-03-01

    To explore the ability of an integrated health information infrastructure to support outcomes research. A systematic review of articles published from 1983 to 2012 by Regenstrief Institute investigators using data from an integrated electronic health record infrastructure involving multiple provider organisations was performed. Articles were independently assessed and classified by study design, disease and other metadata including bibliometrics. A total of 190 articles were identified. Diseases included cognitive, (16) cardiovascular, (16) infectious, (15) chronic illness (14) and cancer (12). Publications grew steadily (26 in the first decade vs. 100 in the last) as did the number of investigators (from 15 in 1983 to 62 in 2012). The proportion of articles involving non-Regenstrief authors also expanded from 54% in the first decade to 72% in the last decade. During this period, the infrastructure grew from a single health system into a health information exchange network covering more than 6 million patients. Analysis of journal and article metrics reveals high impact for clinical trials and comparative effectiveness research studies that utilised data available in the integrated infrastructure. Integrated information infrastructures support growth in high quality observational studies and diverse collaboration consistent with the goals for the learning health system. More recent publications demonstrate growing external collaborations facilitated by greater access to the infrastructure and improved opportunities to study broader disease and health outcomes. Integrated information infrastructures can stimulate learning from electronic data captured during routine clinical care but require time and collaboration to reach full potential. © 2015 Health Libraries Group.

  10. Statistical Methodologies to Integrate Experimental and Computational Research

    Science.gov (United States)

    Parker, P. A.; Johnson, R. T.; Montgomery, D. C.

    2008-01-01

    Development of advanced algorithms for simulating engine flow paths requires the integration of fundamental experiments with the validation of enhanced mathematical models. In this paper, we provide an overview of statistical methods to strategically and efficiently conduct experiments and computational model refinement. Moreover, the integration of experimental and computational research efforts is emphasized. With a statistical engineering perspective, scientific and engineering expertise is combined with statistical sciences to gain deeper insights into experimental phenomenon and code development performance; supporting the overall research objectives. The particular statistical methods discussed are design of experiments, response surface methodology, and uncertainty analysis and planning. Their application is illustrated with a coaxial free jet experiment and a turbulence model refinement investigation. Our goal is to provide an overview, focusing on concepts rather than practice, to demonstrate the benefits of using statistical methods in research and development, thereby encouraging their broader and more systematic application.

  11. Integrating social sciences and humanities in interdisciplinary research

    DEFF Research Database (Denmark)

    Pedersen, David Budtz

    2016-01-01

    drivers for embedding SSH research in interdisciplinary research. By analysing recent policy initiatives, the article shows how policymakers across the world continue to be ambivalent regarding the role of the SSH. While many stakeholders acknowledge the need to integrate SSH research in solving key...... societal challenges, such as climate change, migration or national security, funding for SSH is limited and tends to focus on strategic interventions and instrumental solutions. By accounting for the diversity of interdisciplinary collaborations the article recommends a more context-sensitive approach...

  12. Value-Added Products Derived from Waste Activated Sludge: A Biorefinery Perspective

    Directory of Open Access Journals (Sweden)

    Wei Zhang

    2018-04-01

    Full Text Available Substantial research has been carried out on sustainable waste activated sludge (WAS management in the last decade. In addition to the traditional approach to reduce its production volume, considering WAS as a feedstock to produce bio-products such as amino acids, proteins, short chain fatty acids, enzymes, bio-pesticides, bio-plastics, bio-flocculants and bio-surfactants represents a key component in the transformation of wastewater treatment plants into biorefineries. The quality of these bio-products is a key factor with respect to the feasibility of non-conventional WAS-based production processes. This review provides a critical assessment of the production process routes of a wide range of value-added products from WAS, their current limitations, and recommendations for future research to help promote more sustainable management of this under-utilised and ever-growing waste stream.

  13. Research and Development Needs for Building-Integrated Solar Technologies

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-01-01

    The Building Technologies Office (BTO) has identified Building Integrated Solar Technologies (BIST) as a potentially valuable piece of the comprehensive pathway to help achieve its goal of reducing energy consumption in residential and commercial buildings by 50% by the year 2030. This report helps to identify the key research and development (R&D) needs that will be required for BIST to make a substantial contribution toward that goal. BIST include technologies for space heating and cooling, water heating, hybrid photovoltaic-thermal systems (PV/T), active solar lighting, and building-integrated photovoltaics (BIPV).

  14. Social research design: framework for integrating philosophical and practical elements.

    Science.gov (United States)

    Cunningham, Kathryn Burns

    2014-09-01

    To provide and elucidate a comprehensible framework for the design of social research. An abundance of information exists concerning the process of designing social research. The overall message that can be gleaned is that numerable elements - both philosophical (ontological and epistemological assumptions and theoretical perspective) and practical (issue to be addressed, purpose, aims and research questions) - are influential in the process of selecting a research methodology and methods, and that these elements and their inter-relationships must be considered and explicated to ensure a coherent research design that enables well-founded and meaningful conclusions. There is a lack of guidance concerning the integration of practical and philosophical elements, hindering their consideration and explication. The author's PhD research into loneliness and cancer. This is a methodology paper. A guiding framework that incorporates all of the philosophical and practical elements influential in social research design is presented. The chronological and informative relationships between the elements are discussed. The framework presented can be used by social researchers to consider and explicate the practical and philosophical elements influential in the selection of a methodology and methods. It is hoped that the framework presented will aid social researchers with the design and the explication of the design of their research, thereby enhancing the credibility of their projects and enabling their research to establish well-founded and meaningful conclusions.

  15. Biological potential of microalgae in China for biorefinery-based production of biofuels and high value compounds.

    Science.gov (United States)

    Li, Jingjing; Liu, Ying; Cheng, Jay J; Mos, Michal; Daroch, Maurycy

    2015-12-25

    Microalgae abundance and diversity in China shows promise for identifying suitable strains for developing algal biorefinery. Numerous strains of microalgae have already been assessed as feedstocks for bioethanol and biodiesel production, but commercial scale algal biofuel production is yet to be demonstrated, most likely due to huge energy costs associated with algae cultivation, harvesting and processing. Biorefining, integrated processes for the conversion of biomass into a variety of products, can improve the prospects of microalgal biofuels by combining them with the production of high value co-products. Numerous microalgal strains in China have been identified as producers of various high value by-products with wide application in the medicine, food, and cosmetics industries. This paper reviews microalgae resources in China and their potential in producing liquid biofuels (bioethanol and biodiesel) and high value products in an integrated biorefinery approach. Implementation of a 'high value product first' principle should make the integrated process of fuels and chemicals production economically feasible and will ensure that public and private interest in the development of microalgal biotechnology is maintained. Copyright © 2015 Elsevier B.V. All rights reserved.

  16. Southern Pine Based on Biorefinery Center

    Energy Technology Data Exchange (ETDEWEB)

    Ragauskas, Arthur J. [Georgia Inst. of Technology, Atlanta, GA (United States); Singh, Preet [Georgia Inst. of Technology, Atlanta, GA (United States)

    2013-12-20

    This program seeks to develop an integrated southern pine wood to biofuels/biomaterials processing facility on the Recipient’s campus, that will test advanced integrated wood processing technologies at the laboratory scale, including: The generation of the bioethanol from pines residues and hemicelluloses extracted from pine woodchips; The conversion of extracted woodchips to linerboard and bleach grade pulps; and the efficient conversion of pine residues, bark and kraft cooking liquor into a useful pyrolysis oil.

  17. Current state of seagrass ecosystem services: Research and policy integration

    KAUST Repository

    Ruiz-Frau, A.

    2017-10-12

    Seagrasses contribute to the maintenance of human wellbeing. However certain aspects of their role as ecosystem service (ES) providers remain understudied. Here, we synthesise the state of seagrass ES (SGES) research and policy implications. Additionally, we recommend ways in which SGES research can be integrated in to policy design, by drawing lessons from the case of Blue Carbon (BC). SGES research suffers from three main biases: a geographical bias, SGES has been restricted to chartered seagrass areas; a type of service research bias, provisioning and regulating services have received extensive attention while cultural services remain understudied; a type of discipline bias, the ecological aspects of SGES have been well documented while economic and social aspects remain in comparison understudied. These are particularly important, as an understanding of the social and economic considerations of the provision of ES is fundamental to facilitate its integration into policy frameworks. Lessons drawn from the operationalization process of BC show the reoccurrence of certain aspects that have enabled the integration of BC into policy. These aspects are grouped under 4 different categories. From the analysis of these elements we draw lessons that could facilitate the operationalization of other ecosystem services and their incorporation into management policy frameworks.

  18. Integrated Management System, Configuration and Document Control for Research Reactors

    International Nuclear Information System (INIS)

    Steynberg, B.J.; Bruyn, J.F. du

    2017-01-01

    An integrated management system is a single management framework establishing all the processes necessary for the organisation to address all its goals and objectives. Very often only quality, environment and health & safety goals are included when referred to an integrated management system. However, within the research reactor environment such system should include goals pertinent to economic, environmental, health, operational, quality, safeguards, safety, security, and social considerations. One of the important objectives of an integrated management is to create the environment for a healthy safety culture. Configuration management is a disciplined process that involves both management and technical direction to establish and document the design requirements and the physical configuration of the research reactor and to ensure that they remain consistent with each other and the documentation. Configuration is the combination of the physical, functional, and operational characteristics of the structures, systems, and components (SSCs) or parts of the research reactor, operation, or activity. The basic objectives and general principles of configuration management are the same for all research reactors. The objectives of configuration management are to: a) Establish consistency among design requirements, physical configuration, and documentation (including analyses, drawings, and procedures) for the research reactor; b) Maintain this consistency throughout the life of the research reactor, particularly as changes are being made; and c) Retain confidence in the safety of the research reactor. The key elements needed to manage the configuration of research reactors are design requirements, work control, change control, document control, and configuration management assessments. The objective of document control is to ensure that only the most recently approved versions of documents are used in the process of operating, maintaining, and modifying the research reactor

  19. Qualitative case study methodology in nursing research: an integrative review.

    Science.gov (United States)

    Anthony, Susan; Jack, Susan

    2009-06-01

    This paper is a report of an integrative review conducted to critically analyse the contemporary use of qualitative case study methodology in nursing research. Increasing complexity in health care and increasing use of case study in nursing research support the need for current examination of this methodology. In 2007, a search for case study research (published 2005-2007) indexed in the CINAHL, MEDLINE, EMBASE, PsychINFO, Sociological Abstracts and SCOPUS databases was conducted. A sample of 42 case study research papers met the inclusion criteria. Whittemore and Knafl's integrative review method guided the analysis. Confusion exists about the name, nature and use of case study. This methodology, including terminology and concepts, is often invisible in qualitative study titles and abstracts. Case study is an exclusive methodology and an adjunct to exploring particular aspects of phenomena under investigation in larger or mixed-methods studies. A high quality of case study exists in nursing research. Judicious selection and diligent application of literature review methods promote the development of nursing science. Case study is becoming entrenched in the nursing research lexicon as a well-accepted methodology for studying phenomena in health and social care, and its growing use warrants continued appraisal to promote nursing knowledge development. Attention to all case study elements, process and publication is important in promoting authenticity, methodological quality and visibility.

  20. Biorefinery of the brown seaweed Saccharina latissima for fuels and chemicals

    NARCIS (Netherlands)

    Lopez Contreras, A.M.; Harmsen, P.F.H.; Blaauw, R.; Houweling-Tan, G.B.N.; Wal, van der H.; Huijgen, W.J.J.; Hal, van J.W.

    2014-01-01

    Seaweeds (also called macroalgae) are considered a potential biomass feedstock for biorefineries for production of energy and chemicals. In this study, a biorefinery strategy for the brown seaweed Saccharina latissima is described. Fresh S. latissima harvested at the Irish coast contained glucose

  1. Economically viable biochemical processes for the advanced rural biorefinery and downstream recovery operations

    Science.gov (United States)

    Rural biorefineries offer an alternative to traditional ethanol production by providing the opportunity to produce fuel on site to reduce costs associated with biomass transportation thus making the fuel economically viable. Widespread installation of rural biorefineries could lead to increased upt...

  2. Jobs and Economic Development Impact (JEDI) User Reference Guide: Fast Pyrolysis Biorefinery Model

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yimin [National Renewable Energy Lab. (NREL), Golden, CO (United States); Goldberg, Marshall [MRG and Associates, Nevada City, CA (United States)

    2015-02-01

    This guide -- the JEDI Fast Pyrolysis Biorefinery Model User Reference Guide -- was developed to assist users in operating and understanding the JEDI Fast Pyrolysis Biorefinery Model. The guide provides information on the model's underlying methodology, as well as the parameters and data sources used to develop the cost data utilized in the model. This guide also provides basic instruction on model add-in features and a discussion of how the results should be interpreted. Based on project-specific inputs from the user, the JEDI Fast Pyrolysis Biorefinery Model estimates local (e.g., county- or state-level) job creation, earnings, and output from total economic activity for a given fast pyrolysis biorefinery. These estimates include the direct, indirect and induced economic impacts to the local economy associated with the construction and operation phases of biorefinery projects.Local revenue and supply chain impacts as well as induced impacts are estimated using economic multipliers derived from the IMPLAN software program. By determining the local economic impacts and job creation for a proposed biorefinery, the JEDI Fast Pyrolysis Biorefinery Model can be used to field questions about the added value biorefineries might bring to a local community.

  3. Advanced tokamak research with integrated modeling in JT-60 Upgrade

    International Nuclear Information System (INIS)

    Hayashi, N.

    2010-01-01

    Researches on advanced tokamak (AT) have progressed with integrated modeling in JT-60 Upgrade [N. Oyama et al., Nucl. Fusion 49, 104007 (2009)]. Based on JT-60U experimental analyses and first principle simulations, new models were developed and integrated into core, rotation, edge/pedestal, and scrape-off-layer (SOL)/divertor codes. The integrated models clarified complex and autonomous features in AT. An integrated core model was implemented to take account of an anomalous radial transport of alpha particles caused by Alfven eigenmodes. It showed the reduction in the fusion gain by the anomalous radial transport and further escape of alpha particles. Integrated rotation model showed mechanisms of rotation driven by the magnetic-field-ripple loss of fast ions and the charge separation due to fast-ion drift. An inward pinch model of high-Z impurity due to the atomic process was developed and indicated that the pinch velocity increases with the toroidal rotation. Integrated edge/pedestal model clarified causes of collisionality dependence of energy loss due to the edge localized mode and the enhancement of energy loss by steepening a core pressure gradient just inside the pedestal top. An ideal magnetohydrodynamics stability code was developed to take account of toroidal rotation and clarified a destabilizing effect of rotation on the pedestal. Integrated SOL/divertor model clarified a mechanism of X-point multifaceted asymmetric radiation from edge. A model of the SOL flow driven by core particle orbits which partially enter the SOL was developed by introducing the ion-orbit-induced flow to fluid equations.

  4. Interdisciplinarity, Qualitative Research, and the Complex Phenomenon: Toward an Integrative Approach to Intercultural Research

    Science.gov (United States)

    Ryan, Phillip; Kurtz, Jill Sornsen; Carter, Deanne; Pester, Danielle

    2014-01-01

    This article is a collaboration by the lead faculty member in a Masters program in Intercultural Studies and students who completed the program under his aegis. This article presents the program's approach to its research course sequence, an approach involving the integration of interdisciplinary and qualitative research. The authors first provide…

  5. Panafrican Research Agenda on the Integration of ICTs in Education ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Panafrican Research Agenda on the Pedagogical Integration of Information and Communication Technologies (PanAf). Études. Solutions camerounaises aux problèmes d'infrastructure et d'accès aux T.I.C dans les lycées et collèges. Études. Qualité de l'enseignement et de l'apprentissage sur ordinateur dans les écoles ...

  6. Danish integrated antimicrobial in resistance monitoring and research program

    DEFF Research Database (Denmark)

    Hammerum, Anette Marie; Heuer, Ole Eske; Emborg, Hanne-Dorthe

    2007-01-01

    a systematic and continuous monitoring program of antimicrobial drug consumption and antimicrobial agent resistance in animals, food, and humans, the Danish Integrated Antimicrobial Resistance Monitoring and Research Program (DANMAP). Monitoring of antimicrobial drug resistance and a range of research......Resistance to antimicrobial agents is an emerging problem worldwide. Awareness of the undesirable consequences of its widespread occurrence has led to the initiation of antimicrobial agent resistance monitoring programs in several countries. In 1995, Denmark was the first country to establish...... activities related to DANMAP have contributed to restrictions or bans of use of several antimicrobial agents in food animals in Denmark and other European Union countries....

  7. Research Developments on Power System Integration of Wind Power

    DEFF Research Database (Denmark)

    Chen, Zhe; Hansen, Jens Carsten; Wu, Qiuwei

    2011-01-01

    variability and prediction, wind power plant ancillary services, grid connection and operation, Smart grids and demand side management under market functionality. The topics of the first group of PhD program starting 2011 under the wind energy Sino-Danish Centre for Education & Research (SDC) are also......This paper presents an overview on the recent research activities and tendencies regarding grid integration of wind power in Denmark and some related European activities, including power electronics for enhancing wind power controllability, wind turbines and wind farms modeling, wind power...

  8. Bio-Refineries Bioprocess Technologies for Waste-Water Treatment, Energy and Product Valorization

    Science.gov (United States)

    Keith Cowan, A.

    2010-04-01

    Increasing pressure is being exerted on communities and nations to source energy from forms other than fossil fuels. Also, potable water is becoming a scarce resource in many parts of the world, and there remains a large divide in the demand and utilization of plant products derived from genetically modified organisms (GMOs) and non-GMOs. The most extensive user and manager of terrestrial ecosystems is agriculture which is also the de facto steward of natural resources. As stated by Miller (2008) no other industry or institution comes close to the comparative advantage held for this vital responsibility while simultaneously providing food, fiber, and other biology-based products, including energy. Since modern commercial agriculture is transitioning from the production of bulk commodities to the provision of standardized products and specific-attribute raw materials for differentiated markets, we can argue that processes such as mass cultivation of microalgae and the concept of bio-refineries be seen as part of a `new' agronomy. EBRU is currently exploring the integration of bioprocess technologies using microalgae as biocatalysts to achieve waste-water treatment, water polishing and endocrine disruptor (EDC) removal, sustainable energy production, and exploitation of the resultant biomass in agriculture as foliar fertilizer and seed coatings, and for commercial extraction of bulk commodities such as bio-oils and lecithin. This presentation will address efforts to establish a fully operational solar-driven microalgae bio-refinery for use not only in waste remediation but to transform waste and biomass to energy, fuels, and other useful materials (valorisation), with particular focus on environmental quality and sustainability goals.

  9. Science and Society: Integrity and honesty in research

    CERN Multimedia

    2003-01-01

    Results that contradict known physics, data manipulated, lack of vigilance by co-authors, failures in the system for scientific publication... Last September a US Committee of Enquiry unveiled one of the most serious frauds in the history of physics. Over a two year period, a young researcher at Bell Laboratories had published a large number of articles with exciting results for solid state physics, but which, alas, were fraudulent! Obviously a fraud of this magnitude is exceptional. However, it did serve to focus attention on the problem of integrity and honesty in research practices. This subject, crucial to the well-being and credibility of scientific research, will be the central theme of the lecture given by Nicholas Steneck, Professor of History at the University of Michigan. A leading expert on this issue, on which he has published extensively, he is a consultant to the Office of Research Integrity in the US, and has been closely involved in public policy-making in relation to questions of research int...

  10. Quantifying complexity in translational research: an integrated approach.

    Science.gov (United States)

    Munoz, David A; Nembhard, Harriet Black; Kraschnewski, Jennifer L

    2014-01-01

    The purpose of this paper is to quantify complexity in translational research. The impact of major operational steps and technical requirements is calculated with respect to their ability to accelerate moving new discoveries into clinical practice. A three-phase integrated quality function deployment (QFD) and analytic hierarchy process (AHP) method was used to quantify complexity in translational research. A case study in obesity was used to usability. Generally, the evidence generated was valuable for understanding various components in translational research. Particularly, the authors found that collaboration networks, multidisciplinary team capacity and community engagement are crucial for translating new discoveries into practice. As the method is mainly based on subjective opinion, some argue that the results may be biased. However, a consistency ratio is calculated and used as a guide to subjectivity. Alternatively, a larger sample may be incorporated to reduce bias. The integrated QFD-AHP framework provides evidence that could be helpful to generate agreement, develop guidelines, allocate resources wisely, identify benchmarks and enhance collaboration among similar projects. Current conceptual models in translational research provide little or no clue to assess complexity. The proposed method aimed to fill this gap. Additionally, the literature review includes various features that have not been explored in translational research.

  11. Integrating research evidence and physical activity policy making

    DEFF Research Database (Denmark)

    Aro, Arja R.; Bertram, Maja; Hämäläinen, Riitta-Maija

    2016-01-01

    Evidence shows that regular physical activity is enhanced by supporting environment. Studies are needed to integrate research evidence into health enhancing, cross-sector physical activity (HEPA) policy making. This article presents the rationale, study design, measurement procedures...... and the initial results of the first phase of six European countries in a five-year research project (2011-2016), REsearch into POlicy to enhance Physical Activity (REPOPA). REPOPA is programmatic research; it consists of linked studies; the first phase studied the use of evidence in 21 policies in implementation...... to learn more in depth from the policy making process and carried out 86 qualitative stakeholder interviews. The second, ongoing phase builds on the central findings of the first phase in each country; it consists of two sets of interventions: game simulations to study cross-sector collaboration...

  12. Integrating climate change into agricultural research for development in Africa

    Energy Technology Data Exchange (ETDEWEB)

    Chambwera, Muyeye; Anderson, Simon

    2011-09-15

    African agriculture is already struggling to meet increasing demand for food. Climate change, which will alter agroecological conditions and looks set to arrest and decrease agricultural yields on the continent, will make it even harder to achieve food security. Boosting agricultural productivity in Africa, especially in the face of climate change, cannot be achieved without the benefits of cutting edge science. Advances in technology development and transfer, capacity building and policy research must be harnessed by developing and disseminating relevant strategies and technologies, and improving policy environments. The European Initiative for Agricultural Research for Development (EIARD), which facilitates and coordinates European policy and support for agricultural research for development, must integrate climate change into its activities and ensure that agricultural research for development and climate change adaptation are not disjointed. This demands a more strategic and coordinated approach from the initiative — one that reflects African realities, responds to African priorities for adaptation and development, and makes the best use of limited resources.

  13. Production of a generic microbial feedstock for lignocellulose biorefineries through sequential bioprocessing.

    Science.gov (United States)

    Chang, Chen-Wei; Webb, Colin

    2017-03-01

    Lignocellulosic materials, mostly from agricultural and forestry residues, provide a potential renewable resource for sustainable biorefineries. Reducing sugars can be produced only after a pre-treatment stage, which normally involves chemicals but can be biological. In this case, two steps are usually necessary: solid-state cultivation of fungi for deconstruction, followed by enzymatic hydrolysis using cellulolytic enzymes. In this research, the utilisation of solid-state bioprocessing using the fungus Trichoderma longibrachiatum was implemented as a simultaneous microbial pretreatment and in-situ enzyme production method for fungal autolysis and further enzyme hydrolysis of fermented solids. Suspending the fermented solids in water at 50°C led to the highest hydrolysis yields of 226mg/g reducing sugar and 7.7mg/g free amino nitrogen (FAN). The resultant feedstock was shown to be suitable for the production of various products including ethanol. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Research Integrity and Research Ethics in Professional Codes of Ethics: Survey of Terminology Used by Professional Organizations across Research Disciplines.

    Science.gov (United States)

    Komić, Dubravka; Marušić, Stjepan Ljudevit; Marušić, Ana

    2015-01-01

    Professional codes of ethics are social contracts among members of a professional group, which aim to instigate, encourage and nurture ethical behaviour and prevent professional misconduct, including research and publication. Despite the existence of codes of ethics, research misconduct remains a serious problem. A survey of codes of ethics from 795 professional organizations from the Illinois Institute of Technology's Codes of Ethics Collection showed that 182 of them (23%) used research integrity and research ethics terminology in their codes, with differences across disciplines: while the terminology was common in professional organizations in social sciences (82%), mental health (71%), sciences (61%), other organizations had no statements (construction trades, fraternal social organizations, real estate) or a few of them (management, media, engineering). A subsample of 158 professional organizations we judged to be directly involved in research significantly more often had statements on research integrity/ethics terminology than the whole sample: an average of 10.4% of organizations with a statement (95% CI = 10.4-23-5%) on any of the 27 research integrity/ethics terms compared to 3.3% (95% CI = 2.1-4.6%), respectively (Porganizations should define research integrity and research ethics issues in their ethics codes and collaborate within and across disciplines to adequately address responsible conduct of research and meet contemporary needs of their communities.

  15. Research Integrity and Research Ethics in Professional Codes of Ethics: Survey of Terminology Used by Professional Organizations across Research Disciplines

    Science.gov (United States)

    Komić, Dubravka; Marušić, Stjepan Ljudevit; Marušić, Ana

    2015-01-01

    Professional codes of ethics are social contracts among members of a professional group, which aim to instigate, encourage and nurture ethical behaviour and prevent professional misconduct, including research and publication. Despite the existence of codes of ethics, research misconduct remains a serious problem. A survey of codes of ethics from 795 professional organizations from the Illinois Institute of Technology’s Codes of Ethics Collection showed that 182 of them (23%) used research integrity and research ethics terminology in their codes, with differences across disciplines: while the terminology was common in professional organizations in social sciences (82%), mental health (71%), sciences (61%), other organizations had no statements (construction trades, fraternal social organizations, real estate) or a few of them (management, media, engineering). A subsample of 158 professional organizations we judged to be directly involved in research significantly more often had statements on research integrity/ethics terminology than the whole sample: an average of 10.4% of organizations with a statement (95% CI = 10.4-23-5%) on any of the 27 research integrity/ethics terms compared to 3.3% (95% CI = 2.1–4.6%), respectively (Pethics concepts used prescriptive language in describing the standard of practice. Professional organizations should define research integrity and research ethics issues in their ethics codes and collaborate within and across disciplines to adequately address responsible conduct of research and meet contemporary needs of their communities. PMID:26192805

  16. Integrated modelling of ecosystem services and energy systems research

    Science.gov (United States)

    Agarwala, Matthew; Lovett, Andrew; Bateman, Ian; Day, Brett; Agnolucci, Paolo; Ziv, Guy

    2016-04-01

    The UK Government is formally committed to reducing carbon emissions and protecting and improving natural capital and the environment. However, actually delivering on these objectives requires an integrated approach to addressing two parallel challenges: de-carbonising future energy system pathways; and safeguarding natural capital to ensure the continued flow of ecosystem services. Although both emphasise benefiting from natural resources, efforts to connect natural capital and energy systems research have been limited, meaning opportunities to improve management of natural resources and meet society's energy needs could be missed. The ecosystem services paradigm provides a consistent conceptual framework that applies in multiple disciplines across the natural and economic sciences, and facilitates collaboration between them. At the forefront of the field, integrated ecosystem service - economy models have guided public- and private-sector decision making at all levels. Models vary in sophistication from simple spreadsheet tools to complex software packages integrating biophysical, GIS and economic models and draw upon many fields, including ecology, hydrology, geography, systems theory, economics and the social sciences. They also differ in their ability to value changes in natural capital and ecosystem services at various spatial and temporal scales. Despite these differences, current models share a common feature: their treatment of energy systems is superficial at best. In contrast, energy systems research has no widely adopted, unifying conceptual framework that organises thinking about key system components and interactions. Instead, the literature is organised around modelling approaches, including life cycle analyses, econometric investigations, linear programming and computable general equilibrium models. However, some consistencies do emerge. First, often contain a linear set of steps, from exploration to resource supply, fuel processing, conversion

  17. Overview of Dynamics Integration Research (DIR) program at Langley Research Center

    Science.gov (United States)

    Sliwa, Steven M.; Abel, Irving

    1989-01-01

    Research goals and objectives for an ongoing activity at Langley Research Center (LaRC) are described. The activity is aimed principally at dynamics optimization for aircraft. The effort involves active participation by the Flight Systems, Structures, and Electronics directorates at LaRC. The Functional Integration Technology (FIT) team has been pursuing related goals since 1985. A prime goal has been the integration and optimization of vehicle dynamics through collaboration at the basic principles or equation level. Some significant technical progress has been accomplished since then and is reflected here. An augmentation for this activity, Dynamics Integration Research (DIR), has been proposed to NASA Headquarters and is being considered for funding in FY 1990 or FY 1991.

  18. Integrated and Gender-Affirming Transgender Clinical Care and Research

    Science.gov (United States)

    Radix, Asa; Deutsch, Madeline B.

    2016-01-01

    Abstract: Transgender (trans) communities worldwide, particularly those on the trans feminine spectrum, are disproportionately burdened by HIV infection and at risk for HIV acquisition/transmission. Trans individuals represent an underserved, highly stigmatized, and under-resourced population not only in HIV prevention efforts but also in delivery of general primary medical and clinical care that is gender affirming. We offer a model of gender-affirmative integrated clinical care and community research to address and intervene on disparities in HIV infection for transgender people. We define trans terminology, briefly review the social epidemiology of HIV infection among trans individuals, highlight gender affirmation as a key social determinant of health, describe exemplar models of gender-affirmative clinical care in Boston MA, New York, NY, and San Francisco, CA, and offer suggested “best practices” for how to integrate clinical care and research for the field of HIV prevention. Holistic and culturally responsive HIV prevention interventions must be grounded in the lived realities the trans community faces to reduce disparities in HIV infection. HIV prevention interventions will be most effective if they use a structural approach and integrate primary concerns of transgender people (eg, gender-affirmative care and management of gender transition) alongside delivery of HIV-related services (eg, biobehavioral prevention, HIV testing, linkage to care, and treatment). PMID:27429189

  19. Strengthening integrated research and capacity development within the Caribbean region

    Directory of Open Access Journals (Sweden)

    Dewailly Eric

    2011-11-01

    Full Text Available Abstract Background The Caribbean region, like other developing regions of the world, faces significant challenges in conducting research, especially in the context of limited resource capacities and capabilities. Further, due to its diverse and multiple island states, research capacity is scattered and unevenly spread within the region. The Caribbean EcoHealth Programme (CEHP is a research program that is structured to improve the capacity and capability of health professionals in the Caribbean region to respond in integrative and innovative ways to on-going and emerging environmental health challenges by means of multi-sectoral interventions. Methods Core parts of the CEHP’s mission are to (1 conduct collaborative research in areas that the region has identified as critical; (2 build and strengthening integrated approaches to research; and (3 develop and enhance basic research capacity within the Caribbean region. Fundamental to the success of the CEHP’s human and resource development mission has been its use of the Atlantis Mobile Laboratory (AML. The AML has allowed the CEHP program to move throughout the Caribbean and be able to respond to calls for specific research and capacity building opportunities. Results The CEHP’s five main research projects have generated the following results: (1 the Persistent Organic Pollutants (POPs study has evaluated human exposures to POPs, heavy metals, pesticides, and zoonotic infections; (2 the Burden of Illness (BOI studies have developed protocols for the testing of foodborne microorganisms, strengthen laboratory analytical capabilities, and determined the prevalence and incidence of food-borne illness; (3 the Rainwater Harvesting (RWH study has evaluated the microbial and chemical quality of rainwater harvesting systems; (4 the Ecotoxicology Water (ETW studies have provided much needed data on the quality of recreational and drinking water supplies, and (5 the Food Safety Training Program has

  20. An integrative review of Reiki touch therapy research.

    Science.gov (United States)

    Vitale, Anne

    2007-01-01

    Reiki touch therapy is a complementary biofield energy therapy that involves the use of hands to help strengthen the body's ability to heal. There is growing interest among nurses to use Reiki in patient care and as a self-care treatment, however, with little supportive empirical research and evidence to substantiate these practices. The purpose of this integrative review is to begin the systematic process of evaluating the findings of published Reiki research. Selected investigations using Reiki for effects on stress, relaxation, depression, pain, and wound healing management, among others is reviewed and summarized. A summary of Reiki studies table illustrates the study descriptions and Reiki treatment protocols specified in the investigations. Synthesis of findings for clinical practice and implications for future research are explored.

  1. Knowledge Integration and Inter-Disciplinary Communication in Action Research

    Directory of Open Access Journals (Sweden)

    Hahn Heidi Ann

    2014-08-01

    Full Text Available In a plenary talk at WMSCI 2012 entitled "Planning for Action Research: Looking at Practice through a Different Lens," this author asserted that behavioral science practitioners, often "back into" action research – they start out doing a process improvement or intervention and discover something along the way, i.e., generalizable knowledge, that seems worthwhile to share with their community of practice. It was further asserted that, had the efforts been conceived of as research from the outset, the contributions to the body of knowledge would be more robust and the utility of the projects would improve as well. This paper continues on that theme. Action research and process improvement methods are briefly described and compared. A comparison of two Los Alamos National Laboratory engineering ethics training projects – one developed using a process improvement framework, the other using an action research framework – is put forth to provide evidence that use of a research "lens" can enhance behavioral science interventions and the knowledge that may result from them. The linkage between the Specifying Learning and Diagnosing stages of the Action Research Cycle provides one mechanism for integrating the knowledge gained into the product or process being studied and should provide a reinforcing loop that leads to continual improvement. The collaborative relationships among researchers and the individual, group, or organization that is the subject of the imp rovement op p ortunity (the "client", who are likely from very different backgrounds, and the interpretive epistemology that are among the hallmarks of action research also contribute to the quality of the knowledge gained. This paper closes with a discussion of how Inter-Disciplinary Communication is embedded within the action research paradigm and how this likely also enriches the knowledge gained.

  2. Valorization of lignin from biorefineries for fuels and chemicals

    DEFF Research Database (Denmark)

    Nielsen, Joachim Bachmann

    Direct lignin liquefaction is a promising process for lignin valorization in which ligninis treated in a solvent at elevated temperature and pressure. Liquefaction of sulfur freelignin obtained as a waste product from 2nd generation bio-ethanol production canprovide a sulfur free bio-oil which may...... substitute fossil fuel.In this Ph.D. study the direct liquefaction of a biorefinery lignin (hydrothermallypretreated enzymatic hydrolysis lignin) is explored. The goal is to provide a bio-crude which can substitute marine diesel as the engines found aboard large ships are adapted to more crude fuels. A novel...

  3. From Landscape Research to Landscape Planning : Aspects of Integration, Education and Application

    NARCIS (Netherlands)

    Tress, B.; Tress, G.; Fry, G.; Opdam, P.F.M.

    2006-01-01

    Research policy favours projects that integrate disciplinary knowledge and involve non-academic stakeholders. Consequently, integrative concepts - interdisciplinarity and transdisciplinarity - are gaining currency in landscape research and planning. Researchers are excited by the prospect of merging

  4. Integrated Risk Research. Case of Study: Motozintla, Chiapas, Mexico

    Science.gov (United States)

    Novelo-Casanova, D. A.; Jaimes, M.

    2015-12-01

    This integrated risk research include the analysis of all components of individual constituents of risk such hazard identification, hazard exposure, and vulnerability. We determined risk to natural hazards in the community of Motozintla located in southern Mexico in the state of Chiapas (15.37ºN, 92.25ºW. Due to its geographical and geological location, this community is continuously exposed mainly to earthquakes, landslides and floods. We developed integrated studies and analysis of seismic zonation, landslides and flood susceptibility using standard methodologies. Vulnerability was quantified from data collected from local families interviews considering five social variables: characteristics of housing construction, availability of basic public services, family economic conditions, existing community plans for disaster preparedness, and risk perception. Local families surveyed were randomly selected considering a sample statistically significant. Our results were spatially represented using a Geographical Information System (GIS). Structural vulnerability curves were generated for typical housing constructions. Our integrated risk analysis demonstrates that the community of Motozintla has a high level of structural and socio-economical risk to floods and earthquakes. More than half of the population does not know any existing Civil Protection Plan and perceive that they are in high risk to landslides and floods. Although the community is located in a high seismic risk zone, most of the local people believe that cannot be impacted by a large earthquake. These natural and social conditions indicate that the community of Motozintla has a very high level of risk to natural hazards. This research will support local decision makers in developing an integrated comprehensive natural hazards mitigation and prevention program.

  5. Sustainable bioethanol production combining biorefinery principles and intercropping strategies

    Energy Technology Data Exchange (ETDEWEB)

    Thomsen, M.H.; Haugaard-Nielsen, H.; Petersson, A.; Thomsen, A.B.; Jensen, E.S. [Risoe National Lab., DTU, Biosystems Dept., Roskilde (Denmark)

    2007-05-15

    Ethanol produced from pretreatment and microbial fermentation of biomass has great potential to become a sustainable transportation fuel in the near future. First generation biofuel focus on starch (from grain) fermentation, but in the present study that is regarded as a too important food source. In recent years 2nd generation technologies are developed utilizing bulk residues like wheat straw, woody materials, and corn stover. However, there is a need for integrating the biomass starting point into the energy manufacturing steps to secure that bioenergy is produced from local adapted raw materials with limited use of non-renewable fossil fuels. Produced crops can be transformed into a number of useful products using the concept of biorefining, where no waste streams are produced. An advantage of intercropping is that the intercrop components composition can be designed to produce a medium (for microbial fermentation) containing all essential nutrients. Thereby addition of e.g. urea and other fermentation nutrients produced from fossil fuels can be avoided. Intercropping, defined as the growing of two or more species simultaneously on the same area of land, is a cropping strategy based on the manipulation of plant interactions in time and space to maximize growth and productivity. Cereal-legume intercropping data from field trials show the possibility to improve the use of nitrogen resources, because the non fixing species (e.g. wheat) efficiently exploits soil mineral N sources while at the same time atmospheric N from the N{sub 2}-fixing species (e.g. pea) enter the cropping system reducing the need for N fertilizer application. Nitrogen fertilization is responsible for more than 85 % of the greenhouse gas emissions from wheat grain production in Denmark. Increase of fertilizer N supply promotes the growth of wheat and results in a decreased pea N accumulation and a different proportion of intercrop components. Intercropping introduce a dynamic change of plant

  6. Integrated technology rotor/flight research rotor hub concept definition

    Science.gov (United States)

    Dixon, P. G. C.

    1983-01-01

    Two variations of the helicopter bearingless main rotor hub concept are proposed as bases for further development in the preliminary design phase of the Integrated Technology Rotor/Flight Research Rotor (ITR/FRR) program. This selection was the result of an evaluation of three bearingless hub concepts and two articulated hub concepts with elastomeric bearings. The characteristics of each concept were evaluated by means of simplified methodology. These characteristics included the assessment of stability, vulnerability, weight, drag, cost, stiffness, fatigue life, maintainability, and reliability.

  7. Nurses' hospital orientation and future research challenges: an integrative review.

    Science.gov (United States)

    Peltokoski, J; Vehviläinen-Julkunen, K; Miettinen, M

    2016-03-01

    This study aimed to describe the research on registered nurses' orientation processes in specialized hospital settings in order to illustrate directions for future research. The complex healthcare environment and the impact of nursing shortage and turnover make the hospital orientation process imperative. There is a growing recognition regarding research interests to meet the needs for evidence-based, effective and economically sound hospital orientation strategies. An integrative literature review was performed on publications from the period 2000 to 2013 included in the CINAHL and PubMed databases. English-language studies were included. Themes guiding the analysis were definition of the hospital orientation process, research topics, data collection and instruments and research evidence. Narrative synthesis was used. Eleven papers met the inclusion criteria. The conceptualization of orientation process reflected the complexity of the phenomenon. Less attention has been paid to designs to establish correlations or relationships between selected variables and hospital orientation process. The outcomes of hospital orientation programmes were limited primarily to retention and job satisfaction. The research evidence therefore cannot be evaluated as strong. The lack of an evidence-based approach makes it difficult to develop a comprehensive orientation process. Further research should explore interventions that will enhance the quality of hospital orientation practices to improve nurses' retention and job satisfaction. To provide a comprehensive hospital orientation process, hospital administrators have to put in place human resource development strategies along with practice implications and research efforts. Comprehensive hospital orientation benefits and outcomes should be visible to policy makers. © 2016 International Council of Nurses.

  8. Glass-based integrated optical splitters: engineering oriented research

    Science.gov (United States)

    Hao, Yinlei; Zheng, Weiwei; Yang, Jianyi; Jiang, Xiaoqing; Wang, Minghua

    2010-10-01

    Optical splitter is one of most typical device heavily demanded in implementation of Fiber To The Home (FTTH) system. Due to its compatibility with optical fibers, low propagation loss, flexibility, and most distinguishingly, potentially costeffectiveness, glass-based integrated optical splitters made by ion-exchange technology promise to be very attractive in application of optical communication networks. Aiming at integrated optical splitters applied in optical communication network, glass ion-exchange waveguide process is developed, which includes two steps: thermal salts ion-exchange and field-assisted ion-diffusion. By this process, high performance optical splitters are fabricated in specially melted glass substrate. Main performance parameters of these splitters, including maximum insertion loss (IL), polarization dependence loss (PDL), and IL uniformity are all in accordance with corresponding specifications in generic requirements for optic branching components (GR-1209-CORE). In this paper, glass based integrated optical splitters manufacturing is demonstrated, after which, engineering-oriented research work results on glass-based optical splitter are presented.

  9. Women's career advancement in organisations: Integrative framework for research

    Directory of Open Access Journals (Sweden)

    Mišić-Andrić Marijana

    2015-01-01

    Full Text Available Contemporary organisations, caught in the middle of global economic and social crisis, are facing different business challenges, having to respond to quick changes in business environment and demographic changes in workforce composed by increasing number of women. Although the number of women in workforce is on the rise, they are still underrepresented in manager positions, especially higher management. This implies that certain barriers are in place which makes difficult for women to develop their careers, especially in reaching manager positions. The aim of this paper is to analyse and present a theoretical framework for further study of professional carrier advancement for women. The paper especially analyse integrative theoretical framework which stresses the equal importance of researching individual factors (personal influence and organisational factors (social inclusion, having in mind how the organisational context can improve or deter women's carrier. The paper presents possible directions for future research based on the analysis of the theoretical framework and especially individual and organisational factors.

  10. Rater cognition: review and integration of research findings.

    Science.gov (United States)

    Gauthier, Geneviève; St-Onge, Christina; Tavares, Walter

    2016-05-01

    Given the complexity of competency frameworks, associated skills and abilities, and contexts in which they are to be assessed in competency-based education (CBE), there is an increased reliance on rater judgements when considering trainee performance. This increased dependence on rater-based assessment has led to the emergence of rater cognition as a field of research in health professions education. The topic, however, is often conceptualised and ultimately investigated using many different perspectives and theoretical frameworks. Critically analysing how researchers think about, study and discuss rater cognition or the judgement processes in assessment frameworks may provide meaningful and efficient directions in how the field continues to explore the topic. We conducted a critical and integrative review of the literature to explore common conceptualisations and unified terminology associated with rater cognition research. We identified 1045 articles on rater-based assessment in health professions education using Scorpus, Medline and ERIC and 78 articles were included in our review. We propose a three-phase framework of observation, processing and integration. We situate nine specific mechanisms and sub-mechanisms described across the literature within these phases: (i) generating automatic impressions about the person; (ii) formulating high-level inferences; (iii) focusing on different dimensions of competencies; (iv) categorising through well-developed schemata based on (a) personal concept of competence, (b) comparison with various exemplars and (c) task and context specificity; (v) weighting and synthesising information differently, (vi) producing narrative judgements; and (vii) translating narrative judgements into scales. Our review has allowed us to identify common underlying conceptualisations of observed rater mechanisms and subsequently propose a comprehensive, although complex, framework for the dynamic and contextual nature of the rating process

  11. Microwave-Assisted Extraction for Microalgae: From Biofuels to Biorefinery

    Directory of Open Access Journals (Sweden)

    Rahul Vijay Kapoore

    2018-02-01

    Full Text Available The commercial reality of bioactive compounds and oil production from microalgal species is constrained by the high cost of production. Downstream processing, which includes harvesting and extraction, can account for 70–80% of the total cost of production. Consequently, from an economic perspective extraction technologies need to be improved. Microalgal cells are difficult to disrupt due to polymers within their cell wall such as algaenan and sporopollenin. Consequently, solvents and disruption devices are required to obtain products of interest from within the cells. Conventional techniques used for cell disruption and extraction are expensive and are often hindered by low efficiencies. Microwave-assisted extraction offers a possibility for extraction of biochemical components including lipids, pigments, carbohydrates, vitamins and proteins, individually and as part of a biorefinery. Microwave technology has advanced since its use in the 1970s. It can cut down working times and result in higher yields and purity of products. In this review, the ability and challenges in using microwave technology are discussed for the extraction of bioactive products individually and as part of a biorefinery approach.

  12. Spatially and Temporally Optimal Biomass Procurement Contracting for Biorefineries

    Directory of Open Access Journals (Sweden)

    Subbu Kumarappan

    2014-02-01

    Full Text Available This paper evaluates the optimal composition of annual and perennial biomass feedstocks for a biorefinery. A generic optimization model is built to minimize costs – harvest, transport, storage, seasonal, and environmental costs – subject to various constraints on land availability, feedstock availability, processing capacity, contract terms, and storage losses. The model results are demonstrated through a case study for a midwestern U.S. location, focusing on bioethanol as the likely product. The results suggest that high-yielding energy crops feature prominently (70 to 80% in the feedstock mix in spite of the higher establishment costs. The cost of biomass ranges from 0.16 to 0.20 $ l-1 (US$ 0.60 to $0.75 per gallon of biofuel. The harvest shed shows that high-yielding energy crops are preferably grown in fields closer to the biorefinery. Low-yielding agricultural residues primarily serve as a buffer crop to meet the shortfall in biomass requirement. For the case study parameters, the model results estimated a price premium for energy crops (2 to 4 $ t-1 within a 16 km (10-mile radius and agricultural residues (5 to 17 $ t-1 in a 16 to 20 km (10 to 20 mile radius.

  13. Systematic approach for synthesis of palm oil-based biorefinery

    Energy Technology Data Exchange (ETDEWEB)

    NG, Rex T. L.; NG, Denny K. S.; LAM, Hon Loong [Dept. of Chemical and Environmental Engineering, Centre of Excellence for Green Technologies, Univ. of Nottingham, Selangor, (Malaysia); TAY, Douglas H. S.; LIM, Joseph H. E. [2GGS Eco Solutions Sdn Bhd, Kuala Lumpur (Malaysia)

    2012-11-01

    Various types of palm oil biomasses are generated from palm oil mill when crude palm oil (CPO) is produced from fresh fruit bunch (FFB). In the current practice, palm oil biomasses are used as the main source of energy input in the palm oil mill to produce steam and electricity. Moreover, those biomasses are regarded as by-products and can be reclaimed easily. Therefore, there is a continuous increasing interest concerning biomasses generated from the palm oil mill as a source of renewable energy. Although various technologies have been exploited to produce bio-fuel (i.e., briquette, pellet, etc.) as well as heat and power generation, however, no systematic approach which can analyse and optimise the synthesise biorefinery is presented. In this work, a systematic approach for synthesis and optimisation of palm oil-based biorefinery which including palm oil mill and refinery with maximum economic performance is developed. The optimised network configuration with achieves the maximum economic performance can also be determined. To illustrate the proposed approach, a case study is solved in this work.

  14. Integrated design optimization research and development in an industrial environment

    Science.gov (United States)

    Kumar, V.; German, Marjorie D.; Lee, S.-J.

    1989-01-01

    An overview is given of a design optimization project that is in progress at the GE Research and Development Center for the past few years. The objective of this project is to develop a methodology and a software system for design automation and optimization of structural/mechanical components and systems. The effort focuses on research and development issues and also on optimization applications that can be related to real-life industrial design problems. The overall technical approach is based on integration of numerical optimization techniques, finite element methods, CAE and software engineering, and artificial intelligence/expert systems (AI/ES) concepts. The role of each of these engineering technologies in the development of a unified design methodology is illustrated. A software system DESIGN-OPT has been developed for both size and shape optimization of structural components subjected to static as well as dynamic loadings. By integrating this software with an automatic mesh generator, a geometric modeler and an attribute specification computer code, a software module SHAPE-OPT has been developed for shape optimization. Details of these software packages together with their applications to some 2- and 3-dimensional design problems are described.

  15. Clinical and Outcome Research in oncology The need for integration

    Directory of Open Access Journals (Sweden)

    Apolone Giovanni

    2003-04-01

    the availability of specific knowledge, methods, instruments and resources and upon their appropriate integration in the mainstream of clinical research. In the USA specific interdisciplinary projects have been launched by the NCI. In Europe there is a lack of such initiatives. The correct placement of OR in the anti-cancer drug development process will guarantee the highest possible standard of validity and reliability of OR at European level and better integration of both translational and outcome research in the mainstream of clinical research into anti-cancer drugs, thus speeding up the introduction of the results of patient-oriented translational clinical research into clinical practice.

  16. The Future of Nearshore Processes Research: U.S. Integrated Coastal Research Program

    Science.gov (United States)

    Elko, N.; Feddersen, F.; Foster, D. L.; Hapke, C. J.; Holman, R. A.; McNinch, J.; Mulligan, R. P.; Ozkan-Haller, H. T.; Plant, N. G.; Raubenheimer, B.

    2016-02-01

    The authors, representing the acting Nearshore Advisory Council, have developed an implementation plan for a U.S. Nearshore Research Program based on the 2015 Future of Nearshore Processes report that was authored by the nearshore community. The objectives of the plan are to link research programs across federal agencies, NGOs, industry, and academia into an integrated national program and to increase academic and NGO participation in federal agency nearshore processes research. A primary recommendation is interagency collaboration to build a research program that will coordinate and fund U.S. nearshore processes research across three broad research themes: 1) long-term coastal evolution due to natural and anthropogenic processes; 2) extreme events; and 3) physical, biological and chemical processes impacting human and ecosystem health. The plan calls for a new program to be developed by an executive committee of federal agency leaders, NGOs, and an academic representative, created similarly to the existing NOPP program. This leadership will be established prior to the 2016 Ocean Sciences meeting and will have agreed on responsibilities and a schedule for development of the research program. To begin to understand the scope of today's U.S. coastal research investment, a survey was distributed to ten federal agency R&D program heads. Six of the ten agencies indicated that they fund coastal research, with a combined annual coastal research budget of nearly 100 million (NSF has not responded). The priority of the three research themes were ranked nearly equally and potential research support ranged from 15-19 million for each theme, with approximately 12 million as direct contribution to academic research. Beyond addressing our fundamental science questions, it is critical that the nearshore community stay organized to represent academic interests on the new executive committee. The program goal is the integration of academic, NGO, and federal agencies.

  17. Economically Viable Components from Jerusalem Artichoke (Helianthus tuberosus L.) in a Biorefinery Concept

    DEFF Research Database (Denmark)

    Johansson, Eva; Prade, Thomas; Angelidaki, Irini

    2015-01-01

    Biorefinery applications are receiving growing interest due to climatic and waste disposal issues and lack of petroleum resources. Jerusalem artichoke (Helianthus tuberosus L.) is suitable for biorefinery applications due to high biomass production and limited cultivation requirements. This paper...... focuses on the potential of Jerusalem artichoke as a biorefinery crop and the most viable products in such a case. The carbohydrates in the tubers were found to have potential for production of platform chemicals, e.g., succinic acid. However, economic analysis showed that production of platform chemicals...

  18. Electroporation in food processing and biorefinery.

    Science.gov (United States)

    Mahnič-Kalamiza, Samo; Vorobiev, Eugène; Miklavčič, Damijan

    2014-12-01

    Electroporation is a method of treatment of plant tissue that due to its nonthermal nature enables preservation of the natural quality, colour and vitamin composition of food products. The range of processes where electroporation was shown to preserve quality, increase extract yield or optimize energy input into the process is overwhelming, though not exhausted; e.g. extraction of valuable compounds and juices, dehydration, cryopreservation, etc. Electroporation is--due to its antimicrobial action--a subject of research as one stage of the pasteurization or sterilization process, as well as a method of plant metabolism stimulation. This paper provides an overview of electroporation as applied to plant materials and electroporation applications in food processing, a quick summary of the basic technical aspects on the topic, and a brief discussion on perspectives for future research and development in the field. The paper is a review in the very broadest sense of the word, written with the purpose of orienting the interested newcomer to the field of electroporation applications in food technology towards the pertinent, highly relevant and more in-depth literature from the respective subdomains of electroporation research.

  19. Collaborative Action Research on Technology Integration for Science Learning

    Science.gov (United States)

    Wang, Chien-Hsing; Ke, Yi-Ting; Wu, Jin-Tong; Hsu, Wen-Hua

    2012-02-01

    This paper briefly reports the outcomes of an action research inquiry on the use of blogs, MS PowerPoint [PPT], and the Internet as learning tools with a science class of sixth graders for project-based learning. Multiple sources of data were essential to triangulate the key findings articulated in this paper. Corresponding to previous studies, the incorporation of technology and project-based learning could motivate students in self-directed exploration. The students were excited about the autonomy over what to learn and the use of PPT to express what they learned. Differing from previous studies, the findings pointed to the lack information literacy among students. The students lacked information evaluation skills, note-taking and information synthesis. All these findings imply the importance of teaching students about information literacy and visual literacy when introducing information technology into the classroom. The authors suggest that further research should focus on how to break the culture of "copy-and-paste" by teaching the skills of note-taking and synthesis through inquiry projects for science learning. Also, further research on teacher professional development should focus on using collaboration action research as a framework for re-designing graduate courses for science teachers in order to enhance classroom technology integration.

  20. Bioenergy research advances and applications

    CERN Document Server

    Gupta, Vijai G; Kubicek, Christian P; Saddler, Jack; Xu, Feng

    2014-01-01

    Bioenergy Research: Advances and Applications brings biology and engineering together to address the challenges of future energy needs. The book consolidates the most recent research on current technologies, concepts, and commercial developments in various types of widely used biofuels and integrated biorefineries, across the disciplines of biochemistry, biotechnology, phytology, and microbiology. All the chapters in the book are derived from international scientific experts in their respective research areas. They provide you with clear and concise information on both standard and more recent bioenergy production methods, including hydrolysis and microbial fermentation. Chapters are also designed to facilitate early stage researchers, and enables you to easily grasp the concepts, methodologies and application of bioenergy technologies. Each chapter in the book describes the merits and drawbacks of each technology as well as its usefulness. The book provides information on recent approaches to graduates, post...

  1. Legacy model integration for enhancing hydrologic interdisciplinary research

    Science.gov (United States)

    Dozier, A.; Arabi, M.; David, O.

    2013-12-01

    Many challenges are introduced to interdisciplinary research in and around the hydrologic science community due to advances in computing technology and modeling capabilities in different programming languages, across different platforms and frameworks by researchers in a variety of fields with a variety of experience in computer programming. Many new hydrologic models as well as optimization, parameter estimation, and uncertainty characterization techniques are developed in scripting languages such as Matlab, R, Python, or in newer languages such as Java and the .Net languages, whereas many legacy models have been written in FORTRAN and C, which complicates inter-model communication for two-way feedbacks. However, most hydrologic researchers and industry personnel have little knowledge of the computing technologies that are available to address the model integration process. Therefore, the goal of this study is to address these new challenges by utilizing a novel approach based on a publish-subscribe-type system to enhance modeling capabilities of legacy socio-economic, hydrologic, and ecologic software. Enhancements include massive parallelization of executions and access to legacy model variables at any point during the simulation process by another program without having to compile all the models together into an inseparable 'super-model'. Thus, this study provides two-way feedback mechanisms between multiple different process models that can be written in various programming languages and can run on different machines and operating systems. Additionally, a level of abstraction is given to the model integration process that allows researchers and other technical personnel to perform more detailed and interactive modeling, visualization, optimization, calibration, and uncertainty analysis without requiring deep understanding of inter-process communication. To be compatible, a program must be written in a programming language with bindings to a common

  2. Cultural unconscious in research: integrating multicultural and depth paradigms in qualitative research.

    Science.gov (United States)

    Yakushko, Oksana; Miles, Pekti; Rajan, Indhushree; Bujko, Biljana; Thomas, Douglas

    2016-11-01

    Culturally focused research has gained momentum in many disciplines, including psychology. However, much of this research fails to pay attention to the unconscious dynamics that underlie the study of culture and culturally influenced human beings. Such dynamics may be especially significant when issues of marginalization and oppression are present. Therefore, this paper seeks to contribute a framework for understanding cultural dynamics, especially unconscious cultural dynamics, within depth psychological qualitative research influenced by Jungian and post-Jungian scholarship. Inquiry that is approached with a commitment to making the unconscious conscious seeks to empower and liberate not only the subject/object studied but also the researchers themselves. Following a brief review of multiculturalism in the context of analytically informed psychology, this paper offers several case examples that focus on researchers' integration of awareness of the cultural unconscious in their study of cultural beings and topics. © 2016, The Society of Analytical Psychology.

  3. Thermospheric Density and Composition: an Integrated Research Approach

    Science.gov (United States)

    Richmond, A. D.; Akmaev, R.; Anderson, P. C.; Crowley, G.; Drob, D. P.; Lummerzheim, D.; Solomon, S. C.; Tobiska, W.

    2006-12-01

    The thermosphere, at altitudes of approximately 90-500 km, affects human technological systems through the drag it exerts on low-Earth-orbit spacecraft and debris, and through its influence on the embedded ionosphere, affecting radio-wave transmissions, and, consequently, communications and geolocation. We have formed a team under the NASA Living With a Star Targeted Research and Technology program to carry out an integrated research program on the focused science topic of thermospheric density and composition. Our goal is to improve scientific understanding of the thermosphere-ionosphere system, leading to improved first-principles models that accurately specify the variations of thermospheric density and composition with latitude, longitude, local time, solar flux, season, magnetic activity level, and orientation of the interplanetary magnetic field. We are developing improved quantitative models of solar and magnetospheric inputs to the thermosphere and improved physical parameterizations in the first-principles global models; we are analyzing thermospheric responses to solar and magnetospheric inputs on time scales from minutes to the length of the solar cycle; and we are developing an improved empirical model of thermospheric winds. These research products will be made available to the scientific community. This work is helping to clarify critical problem areas in thermospheric physics for planned NASA missions like the Ionosphere-Thermosphere Storm Probes, Geospace Electrodynamics Connections, and the Global-scale Observation of the Limb and Disk.

  4. The importance of organizational justice in ensuring research integrity.

    Science.gov (United States)

    Martinson, Brian C; Crain, A Lauren; De Vries, Raymond; Anderson, Melissa S

    2010-09-01

    The professional behavior of scientists, for good or ill, is likely associated with their perceptions of whether they are treated fairly in their work environments, including their academic department and university and by relevant regulatory bodies. These relationships may also be influenced by their own personal characteristics, such as being overcommitted to their work, and by the interactions between these factors. Theory also suggests that such associations may be mediated by negative or positive affect. We examined these issues using data from a national, mail-based survey administered in 2006 and 2007 to 5,000 randomly selected faculty from biomedical and social science departments at 50 top-tier research universities in the United States. We found that perceptions of justice in one's workplace (organizational justice) are positively associated with self-report of "ideal" behaviors and negatively associated with self-report of misbehavior and misconduct. By contrast, researchers who perceive that they are being unfairly treated are less likely to report engaging in "ideal" behaviors and more likely to report misbehavior and misconduct. Overcommitment to one's work is also associated with negative affect and interacts with perceptions of unfair treatment in ways that are associated with higher self-report of misbehavior. Thus, perceptions of fair treatment in the work environment appear to play important roles in fostering-or undermining-research integrity.

  5. Integrated research training program of excellence in radiochemistry

    Energy Technology Data Exchange (ETDEWEB)

    Lapi, Suzanne [Washington Univ., St. Louis, MO (United States)

    2015-09-18

    The overall goal of this “Integrated Research Training Program of Excellence in Radiochemistry” is to provide a rich and deep research experience in state-of-the-art radiochemistry and in the fundamentals of radioisotopic labeling and tracer methodology to develop researchers who are capable of meeting the challenges of designing and preparing radiotracers of broad applicability for monitoring and imaging diverse biological systems and environmental processes. This program was based in the Departments of Radiology and Radiation Oncology at Washington University Medical School and the Department of Chemistry at the University of Illinois at Urbana Champaign, and it was initially directed by Professor Michael J. Welch as Principal Investigator. After his passing in 2012, the program was led by Professor Suzanne E. Lapi. Programmatic content and participant progress was overseen by an Internal Advisory Committee of senior investigators consisting of the PIs, Professor Mach from the Department of Radiology at Washington University and Professor John A. Katzenellenbogen of the Department of Chemistry at the University of Illinois. A small External Advisory Committee to give overall program guidance was also constituted of experts in radiolabeled compounds and in their applications in environmental and plant science.

  6. Reactor core materials research and integrated material database establishment

    International Nuclear Information System (INIS)

    Ryu, Woo Seog; Jang, J. S.; Kim, D. W.

    2002-03-01

    Mainly two research areas were covered in this project. One is to establish the integrated database of nuclear materials, and the other is to study the behavior of reactor core materials, which are usually under the most severe condition in the operating plants. During the stage I of the project (for three years since 1999) in- and out of reactor properties of stainless steel, the major structural material for the core structures of PWR (Pressurized Water Reactor), were evaluated and specification of nuclear grade material was established. And the damaged core components from domestic power plants, e.g. orifice of CVCS, support pin of CRGT, etc. were investigated and the causes were revealed. To acquire more resistant materials to the nuclear environments, development of the alternative alloys was also conducted. For the integrated DB establishment, a task force team was set up including director of nuclear materials technology team, and projector leaders and relevant members from each project. The DB is now opened in public through the Internet

  7. International Piping Integrity Research Group (IPIRG) Program. Final report

    International Nuclear Information System (INIS)

    Wilkowski, G.; Schmidt, R.; Scott, P.

    1997-06-01

    This is the final report of the International Piping Integrity Research Group (IPIRG) Program. The IPIRG Program was an international group program managed by the U.S. Nuclear Regulatory Commission and funded by a consortium of organizations from nine nations: Canada, France, Italy, Japan, Sweden, Switzerland, Taiwan, the United Kingdom, and the United States. The program objective was to develop data needed to verify engineering methods for assessing the integrity of circumferentially-cracked nuclear power plant piping. The primary focus was an experimental task that investigated the behavior of circumferentially flawed piping systems subjected to high-rate loadings typical of seismic events. To accomplish these objectives a pipe system fabricated as an expansion loop with over 30 meters of 16-inch diameter pipe and five long radius elbows was constructed. Five dynamic, cyclic, flawed piping experiments were conducted using this facility. This report: (1) provides background information on leak-before-break and flaw evaluation procedures for piping, (2) summarizes technical results of the program, (3) gives a relatively detailed assessment of the results from the pipe fracture experiments and complementary analyses, and (4) summarizes advances in the state-of-the-art of pipe fracture technology resulting from the IPIRG program

  8. Integrating uncertainty into public energy research and development decisions

    Science.gov (United States)

    Anadón, Laura Díaz; Baker, Erin; Bosetti, Valentina

    2017-05-01

    Public energy research and development (R&D) is recognized as a key policy tool for transforming the world's energy system in a cost-effective way. However, managing the uncertainty surrounding technological change is a critical challenge for designing robust and cost-effective energy policies. The design of such policies is particularly important if countries are going to both meet the ambitious greenhouse-gas emissions reductions goals set by the Paris Agreement and achieve the required harmonization with the broader set of objectives dictated by the Sustainable Development Goals. The complexity of informing energy technology policy requires, and is producing, a growing collaboration between different academic disciplines and practitioners. Three analytical components have emerged to support the integration of technological uncertainty into energy policy: expert elicitations, integrated assessment models, and decision frameworks. Here we review efforts to incorporate all three approaches to facilitate public energy R&D decision-making under uncertainty. We highlight emerging insights that are robust across elicitations, models, and frameworks, relating to the allocation of public R&D investments, and identify gaps and challenges that remain.

  9. International piping integrity research group (IPIRG) program final report

    International Nuclear Information System (INIS)

    Schmidt, R.; Wilkowski, G.; Scott, P.; Olsen, R.; Marschall, C.; Vieth, P.; Paul, D.

    1992-04-01

    This is the final report of the International Piping Integrity Research Group (IPIRG) Programme. The IPIRG Programme was an international group programme managed by the U.S. Nuclear Regulatory Commission and funded by a consortium of organizations from nine nations: Canada, France, Italy, Japan, Sweden, Switzerland, Taiwan, the United Kingdom, and the United states. The objective of the programme was to develop data needed to verify engineering methods for assessing the integrity of nuclear power plant piping that contains circumferential defects. The primary focus was an experimental task that investigated the behaviour of circumferentially flawed piping and piping systems to high-rate loading typical of seismic events. To accomplish these objectives a unique pipe loop test facility was designed and constructed. The pipe system was an expansion loop with over 30 m of 406-mm diameter pipe and five long radius elbows. Five experiments on flawed piping were conducted to failure in this facility with dynamic excitation. The report: provides background information on leak-before-break and flaw evaluation procedures in piping; summarizes the technical results of the programme; gives a relatively detailed assessment of the results from the various pipe fracture experiments and complementary analyses; and, summarizes the advances in the state-of-the-art of pipe fracture technology resulting from the IPIRG Program

  10. International Piping Integrity Research Group (IPIRG) Program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Wilkowski, G.; Schmidt, R.; Scott, P. [and others

    1997-06-01

    This is the final report of the International Piping Integrity Research Group (IPIRG) Program. The IPIRG Program was an international group program managed by the U.S. Nuclear Regulatory Commission and funded by a consortium of organizations from nine nations: Canada, France, Italy, Japan, Sweden, Switzerland, Taiwan, the United Kingdom, and the United States. The program objective was to develop data needed to verify engineering methods for assessing the integrity of circumferentially-cracked nuclear power plant piping. The primary focus was an experimental task that investigated the behavior of circumferentially flawed piping systems subjected to high-rate loadings typical of seismic events. To accomplish these objectives a pipe system fabricated as an expansion loop with over 30 meters of 16-inch diameter pipe and five long radius elbows was constructed. Five dynamic, cyclic, flawed piping experiments were conducted using this facility. This report: (1) provides background information on leak-before-break and flaw evaluation procedures for piping, (2) summarizes technical results of the program, (3) gives a relatively detailed assessment of the results from the pipe fracture experiments and complementary analyses, and (4) summarizes advances in the state-of-the-art of pipe fracture technology resulting from the IPIRG program.

  11. Integrated deterministic and probabilistic safety assessment: Concepts, challenges, research directions

    International Nuclear Information System (INIS)

    Zio, Enrico

    2014-01-01

    Highlights: • IDPSA contributes to robust risk-informed decision making in nuclear safety. • IDPSA considers time-dependent interactions among component failures and system process. • Also, IDPSA considers time-dependent interactions among control and operator actions. • Computational efficiency by advanced Monte Carlo and meta-modelling simulations. • Efficient post-processing of IDPSA output by clustering and data mining. - Abstract: Integrated deterministic and probabilistic safety assessment (IDPSA) is conceived as a way to analyze the evolution of accident scenarios in complex dynamic systems, like nuclear, aerospace and process ones, accounting for the mutual interactions between the failure and recovery of system components, the evolving physical processes, the control and operator actions, the software and firmware. In spite of the potential offered by IDPSA, several challenges need to be effectively addressed for its development and practical deployment. In this paper, we give an overview of these and discuss the related implications in terms of research perspectives

  12. IMMIGRANTS’ INTEGRATION IN GREEK SOCIETY: AN EMPIRICAL RESEARCH

    Directory of Open Access Journals (Sweden)

    Anastasios Karasavvoglou

    2011-01-01

    Full Text Available Since the beginning of the 90s, Greece has rapidly become a reception country of a significant number of immigrants. It is estimated that, nowadays, the number of immigrants, both legal and illegal, is approximately 1,2 million. At the same time, Greece is, moreover, being used as an intermediate, temporary station in the immigrants’ effort to reach the countries of the central Europe. Consequently, the existing migration stock of Greece is too significant to be left unexamined, especially since various previous researches indicate that a considerable number of immigrants express their intention to make Greece their place of permanent residence. Therefore, the application of an integration immigration policy in Greek society is considered to be a necessity and the examination of the parameters that will support its effectiveness rises as an important practical issue.

  13. Research and development - an integral part of the business

    Energy Technology Data Exchange (ETDEWEB)

    Clerehugh, G

    1987-02-01

    The overall objectives of British Gas Research and Development Division are outlined together with the customer-contractor relationship between the operating divisions and R and D division which integrates the R and D programme with the needs of the business. Implementation of the results of the R and D programme may be in-house, by a joint venture with a manufacturer or by licensing one or more manufacturers. These methods of implementation are illustrated by description of the development of equipment for on-line inspection of pipelines, the Pegasus computer program for analysis of gas distribution networks and the regenerative burner for recovery of high temperature heat from furnace flue gases.

  14. Networks as integrated in research methodologies in PER

    DEFF Research Database (Denmark)

    Bruun, Jesper

    2016-01-01

    of using networks to create insightful maps of learning discussions. To conclude, I argue that conceptual blending is a powerful framework for constructing "mixed methods" methodologies that may integrate diverse theories and other methodologies with network methodologies.......In recent years a number of researchers within the PER community have started using network analysis as a new methodology to extend our understanding of teaching and learning physics by viewing these as complex systems. In this paper, I give examples of social, cognitive, and action mapping...... networks and how they can be analyzed. In so doing I show how a network can be methodologically described as a set of relations between a set of entities, and how a network can be characterized and analyzed as a mathematical object. Then, as an illustrative example, I discuss a relatively new example...

  15. An integrative approach to research of deforestation under concession management

    International Nuclear Information System (INIS)

    Hepner, G.F.; Walker, R.T.

    1991-01-01

    A methodological approach integrating questionnaire research of tropical foresters with analyses of the actual patterns of concession logging and land use activities portrayed on various types of satellite imagery is discussed. The imagery analysis is necessary to: document the location place and magnitude of forest utilization and change in concession areas; confirm that responses vis-a-vis deforestation in the questionnaire correspond to observable behaviors as evidenced by the actual patterns of logging activities; and document the postharvest land utilization and conversion to other land uses. It is argued that this approach will link the process and pattern of logging activities to reveal the main factors leading to deforestation under the concession system of management. 20 refs

  16. Integrated deterministic and probabilistic safety assessment: Concepts, challenges, research directions

    Energy Technology Data Exchange (ETDEWEB)

    Zio, Enrico, E-mail: enrico.zio@ecp.fr [Ecole Centrale Paris and Supelec, Chair on System Science and the Energetic Challenge, European Foundation for New Energy – Electricite de France (EDF), Grande Voie des Vignes, 92295 Chatenay-Malabry Cedex (France); Dipartimento di Energia, Politecnico di Milano, Via Ponzio 34/3, 20133 Milano (Italy)

    2014-12-15

    Highlights: • IDPSA contributes to robust risk-informed decision making in nuclear safety. • IDPSA considers time-dependent interactions among component failures and system process. • Also, IDPSA considers time-dependent interactions among control and operator actions. • Computational efficiency by advanced Monte Carlo and meta-modelling simulations. • Efficient post-processing of IDPSA output by clustering and data mining. - Abstract: Integrated deterministic and probabilistic safety assessment (IDPSA) is conceived as a way to analyze the evolution of accident scenarios in complex dynamic systems, like nuclear, aerospace and process ones, accounting for the mutual interactions between the failure and recovery of system components, the evolving physical processes, the control and operator actions, the software and firmware. In spite of the potential offered by IDPSA, several challenges need to be effectively addressed for its development and practical deployment. In this paper, we give an overview of these and discuss the related implications in terms of research perspectives.

  17. Carbon recovery by fermentation of CO-rich off gases - Turning steel mills into biorefineries.

    Science.gov (United States)

    Molitor, Bastian; Richter, Hanno; Martin, Michael E; Jensen, Rasmus O; Juminaga, Alex; Mihalcea, Christophe; Angenent, Largus T

    2016-09-01

    Technological solutions to reduce greenhouse gas (GHG) emissions from anthropogenic sources are required. Heavy industrial processes, such as steel making, contribute considerably to GHG emissions. Fermentation of carbon monoxide (CO)-rich off gases with wild-type acetogenic bacteria can be used to produce ethanol, acetate, and 2,3-butanediol, thereby, reducing the carbon footprint of heavy industries. Here, the processes for the production of ethanol from CO-rich off gases are discussed and a perspective on further routes towards an integrated biorefinery at a steel mill is given. Recent achievements in genetic engineering as well as integration of other biotechnology platforms to increase the product portfolio are summarized. Already, yields have been increased and the portfolio of products broadened. To develop a commercially viable process, however, the extraction from dilute product streams is a critical step and alternatives to distillation are discussed. Finally, another critical step is waste(water) treatment with the possibility to recover resources. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. A plan for safety and integrity of research reactor components

    International Nuclear Information System (INIS)

    Moatty, Mona S. Abdel; Khattab, M.S.

    2013-01-01

    Highlights: ► A plan for in-service inspection of research reactor components is put. ► Section XI of the ASME Code requirements is applied. ► Components subjected to inspection and their classes are defined. ► Flaw evaluation and its acceptance–rejection criteria are reviewed. ► A plan of repair or replacement is prepared. -- Abstract: Safety and integrity of a research reactor that has been operated over 40 years requires frequent and thorough inspection of all the safety-related components of the facility. The need of increasing the safety is the need of improving the reliability of its systems. Diligent and extensive planning of in-service inspection (ISI) of all reactor components has been imposed for satisfying the most stringent safety requirements. The Safeguards Officer's responsibilities of Section XI of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code ASME Code have been applied. These represent the most extensive and time-consuming part of ISI program, and identify the components subjected to inspection and testing, methods of component classification, inspection and testing techniques, acceptance/rejection criteria, and the responsibilities. The paper focuses on ISI planning requirements for welded systems such as vessels, piping, valve bodies, pump casings, and control rod-housing parts. The weld in integral attachments for piping, pumps, and valves are considered too. These are taken in consideration of safety class (1, 2, 3, etc.), reactor age, and weld type. The parts involve in the frequency of inspection, the examination requirements for each inspection, the examination method are included. Moreover the flaw evaluation, the plan of repair or replacement, and the qualification of nondestructive examination personnel are considered

  19. Balance and saving of GHG emissions in thermochemical biorefineries

    International Nuclear Information System (INIS)

    Haro, Pedro; Aracil, Cristina; Vidal-Barrero, Fernando; Ollero, Pedro

    2015-01-01

    Highlights: • A simplified methodology for the balance and saving of GHG emissions is provided. • The GHG balance has a physical meaning and does not depend on the fossil reference. • The GHG saving depends on regulation of energy carriers. • The impact of Bio-CCS incorporation and multiproduction is analyzed. • The co-production of chemicals needs to be included in future regulation. - Abstract: In this study, a simplified methodology for the calculation of the balance of greenhouse gas (GHG) emissions and corresponding saving compared with the fossil reference is presented. The proposed methodology allows the estimation of the anthropogenic GHG emissions of thermochemical biorefineries (net emitted to the atmosphere). In the calculation of the GHG balance, all relevant factors have been identified and analyzed including multiproduction, emissions from biogenic carbon capture and storage (Bio-CCS), co-feeding of fossil fuels (secondary feedstock) and possible carbon storage in biomass-derived products (chemicals). Therefore, it is possible to calculate the balance of GHG emissions of a hypothetical thermochemical biorefinery considering different alternatives of land-use, biomass feedstock, co-feeding of fossil fuels, Bio-CCS incorporation and final use of the products. The comparison of the estimated GHG balance with the corresponding fossil reference for each product is of special relevance in the methodology since it is the parameter used in European regulation for the fulfillment of sustainability criteria in biomass-derived fuels and liquids. The proposed methodology is tested using a previously assessed set of different process concepts of thermochemical biorefineries (techno-economic analysis). The resulting GHG balance and saving are analyzed to identify uncertainties and provide recommendations for future regulation. In all process concepts, the GHG savings are above the minimum requirement of GHG emissions for 2018. In the case of incorporating

  20. Pyrolysis based bio-refinery for the production of bioethanol from demineralized ligno-cellulosic biomass

    NARCIS (Netherlands)

    Luque, L.; Westerhof, Roel Johannes Maria; van Rossum, G.; Oudenhoven, Stijn; Kersten, Sascha R.A.; Berruti, F.; Rehmann, L.

    2014-01-01

    This paper evaluates a novel biorefinery approach for the conversion of lignocellulosic biomass from pinewood. A combination of thermochemical and biochemical conversion was chosen with the main product being ethanol. Fast pyrolysis of lignocellulosic biomasss with fractional condensation of the

  1. Ethanol production from rape straw: Part of an oilseed rape biorefinery

    DEFF Research Database (Denmark)

    Arvaniti, Efthalia

    The aim of this study was 1) present an oilseed rape whole crop biorefinery; 2) to investigate the best available experimental conditions for production of cellulosic ethanol from rape straw, and included the processes of thermo-chemical pretreatment, enzymatic hydrolysis, and C6 fermentation......, and 3) to couple cellulosic ethanol production to production of cellulolytic enzymes that are needed for cellulosic ethanol production, inside a rape straw biorefinery. For the first is based less on available experiments, and more on literature review. The second and third study conclusions were drawn...... rapeseed biodiesel plant of Europe to an oilseed rape whole-crop biorefinery by 2020 is envisioned and discussed. The description and discussion of this biorefinery is based partly on literature review, and partly on own experimental data, especially on pretreatment of rape straw, and production...

  2. Journal club: Integrating research awareness into postgraduate nurse training

    Directory of Open Access Journals (Sweden)

    Clare Davis

    2014-12-01

    Full Text Available Background: Evidence-based nursing requires nurses to maintain an awareness of recently published research findings to integrate into their clinical practice. In the South African setting keeping up with recent literature has additional challenges, including the diversity of nurses’ home language, geographically foreign origins of published work, and limited economic resources. Students enrolled in a postgraduate programme came from various paediatric settings and displayed limited awareness of nursing literature as an evidence base for practice. Objectives: The study aimed to design and introduce a journal club as an educational strategy into the postgraduate programmes in children’s nursing at the University of Cape Town (UCT, and then to refine the way it is used to best serve programme outcomes and facilitate student learning whilst still being an enjoyable activity. Method: An action research methodology using successive cycles of ‘assess-plan-act-observe’ was used to design, implement and refine the structure of a journal club within the postgraduate diploma programme over four academic years. Six educators actively tracked and reflected on journal club sessions, and then analysed findings during and after each annual cycle to plan improvement and increasing programme alignment. Results: Considerable refinement of the intervention included changing how it was structured, the preparation required by both students and educators, the article selection process and the intervention’s alignment with other learning activities in the programme. Conclusion: Journal club facilitated an increase in student awareness and reading of nursing literature, offering the opportunity to consider application of published research to current nursing practice. Another benefit was enabling students to become familiar with the specialised and technical language of research, children’s nursing and the critical care of children and neonates, by speaking

  3. Possibilities for sustainable biorefineries based on agricultural residues – A case study of potential straw-based ethanol production in Sweden

    International Nuclear Information System (INIS)

    Ekman, Anna; Wallberg, Ola; Joelsson, Elisabeth; Börjesson, Pål

    2013-01-01

    Highlights: ► Biorefineries can produce ethanol, biogas, heat and power efficiently with profit. ► Location of plant is decided by raw material supply in the region. ► Increased production of high value compounds affects profitability. ► Energy efficiency is increased by availability of heat sinks. ► Several locations may be suitable for construction of a biorefinery plant. -- Abstract: This study presents a survey of the most important techno-economic factors for the implementation of biorefineries based on agricultural residues, in the form of straw, and biochemical conversion into ethanol and biogas, together with production of electricity and heat. The paper suggests locations where the necessary conditions can be met in Sweden. The requirements identified are regional availability of feedstock, the possibility to integrate with external heat sinks, appropriate process design and the scale of the plant. The scale of the plant should be adapted to the potential, regional, raw-material supply, but still be large enough to give economies of scale. The integration with heat sinks proved to be most important to achieve high energy-efficiency, but it was of somewhat less importance for the profitability. Development of pentose fermentation, leading to higher ethanol yields, was important to gain high profitability. Promising locations were identified in the county of Östergötland where integration with an existing 1st generation ethanol plant and district heating systems (DHSs) is possible, and in the county of Skåne where both a significant, potential straw supply and integration potential with DHSs are available.

  4. Research capacity building integrated into PHIT projects: leveraging research and research funding to build national capacity.

    Science.gov (United States)

    Hedt-Gauthier, Bethany L; Chilengi, Roma; Jackson, Elizabeth; Michel, Cathy; Napua, Manuel; Odhiambo, Jackline; Bawah, Ayaga

    2017-12-21

    Inadequate research capacity impedes the development of evidence-based health programming in sub-Saharan Africa. However, funding for research capacity building (RCB) is often insufficient and restricted, limiting institutions' ability to address current RCB needs. The Doris Duke Charitable Foundation's African Health Initiative (AHI) funded Population Health Implementation and Training (PHIT) partnership projects in five African countries (Ghana, Mozambique, Rwanda, Tanzania and Zambia) to implement health systems strengthening initiatives inclusive of RCB. Using Cooke's framework for RCB, RCB activity leaders from each country reported on RCB priorities, activities, program metrics, ongoing challenges and solutions. These were synthesized by the authorship team, identifying common challenges and lessons learned. For most countries, each of the RCB domains from Cooke's framework was a high priority. In about half of the countries, domain specific activities happened prior to PHIT. During PHIT, specific RCB activities varied across countries. However, all five countries used AHI funding to improve research administrative support and infrastructure, implement research trainings and support mentorship activities and research dissemination. While outcomes data were not systematically collected, countries reported holding 54 research trainings, forming 56 mentor-mentee relationships, training 201 individuals and awarding 22 PhD and Masters-level scholarships. Over the 5 years, 116 manuscripts were developed. Of the 59 manuscripts published in peer-reviewed journals, 29 had national first authors and 18 had national senior authors. Trainees participated in 99 conferences and projects held 37 forums with policy makers to facilitate research translation into policy. All five PHIT projects strongly reported an increase in RCB activities and commended the Doris Duke Charitable Foundation for prioritizing RCB, funding RCB at adequate levels and time frames and for allowing

  5. [Integrity].

    Science.gov (United States)

    Gómez Rodríguez, Rafael Ángel

    2014-01-01

    To say that someone possesses integrity is to claim that that person is almost predictable about responses to specific situations, that he or she can prudentially judge and to act correctly. There is a closed interrelationship between integrity and autonomy, and the autonomy rests on the deeper moral claim of all humans to integrity of the person. Integrity has two senses of significance for medical ethic: one sense refers to the integrity of the person in the bodily, psychosocial and intellectual elements; and in the second sense, the integrity is the virtue. Another facet of integrity of the person is la integrity of values we cherish and espouse. The physician must be a person of integrity if the integrity of the patient is to be safeguarded. The autonomy has reduced the violations in the past, but the character and virtues of the physician are the ultimate safeguard of autonomy of patient. A field very important in medicine is the scientific research. It is the character of the investigator that determines the moral quality of research. The problem arises when legitimate self-interests are replaced by selfish, particularly when human subjects are involved. The final safeguard of moral quality of research is the character and conscience of the investigator. Teaching must be relevant in the scientific field, but the most effective way to teach virtue ethics is through the example of the a respected scientist.

  6. Uncertainties in Early Stage Capital Cost Estimation of Process Design – A case study on biorefinery design

    Directory of Open Access Journals (Sweden)

    Gurkan eSin

    2015-02-01

    Full Text Available Capital investment, next to the product demand, sales and production costs, is one of the key metrics commonly used for project evaluation and feasibility assessment. Estimating the investment costs of a new product/process alternative during early stage design is a challenging task. This is especially important in biorefinery research, where available information and experiences with new technologies is limited. A systematic methodology for uncertainty analysis of cost data is proposed that employs (a Bootstrapping as a regression method when cost data is available and (b the Monte Carlo technique as an error propagation method based on expert input when cost data is not available. Four well-known models for early stage cost estimation are reviewed an analyzed using the methodology. The significance of uncertainties of cost data for early stage process design is highlighted using the synthesis and design of a biorefinery as a case study. The impact of uncertainties in cost estimation on the identification of optimal processing paths is found to be profound. To tackle this challenge, a comprehensive techno-economic risk analysis framework is presented to enable robust decision making under uncertainties. One of the results using an order-of-magnitude estimate shows that the production of diethyl ether and 1,3-butadiene are the most promising with economic risks of 0.24 MM$/a and 4.6 MM$/a due to uncertainties in cost estimations, respectively.

  7. Uncertainties in Early-Stage Capital Cost Estimation of Process Design – A Case Study on Biorefinery Design

    International Nuclear Information System (INIS)

    Cheali, Peam; Gernaey, Krist V.; Sin, Gürkan

    2015-01-01

    Capital investment, next to the product demand, sales, and production costs, is one of the key metrics commonly used for project evaluation and feasibility assessment. Estimating the investment costs of a new product/process alternative during early-stage design is a challenging task, which is especially relevant in biorefinery research where information about new technologies and experience with new technologies is limited. A systematic methodology for uncertainty analysis of cost data is proposed that employs: (a) bootstrapping as a regression method when cost data are available; and, (b) the Monte Carlo technique as an error propagation method based on expert input when cost data are not available. Four well-known models for early-stage cost estimation are reviewed and analyzed using the methodology. The significance of uncertainties of cost data for early-stage process design is highlighted using the synthesis and design of a biorefinery as a case study. The impact of uncertainties in cost estimation on the identification of optimal processing paths is indeed found to be profound. To tackle this challenge, a comprehensive techno-economic risk analysis framework is presented to enable robust decision-making under uncertainties. One of the results using order-of-magnitude estimates shows that the production of diethyl ether and 1,3-butadiene are the most promising with the lowest economic risks (among the alternatives considered) of 0.24 MM$/a and 4.6 MM$/a, respectively.

  8. Uncertainties in Early-Stage Capital Cost Estimation of Process Design – A Case Study on Biorefinery Design

    Energy Technology Data Exchange (ETDEWEB)

    Cheali, Peam; Gernaey, Krist V.; Sin, Gürkan, E-mail: gsi@kt.dtu.dk [Department of Chemical and Biochemical Engineering, Technical University of Denmark, Lyngby (Denmark)

    2015-02-06

    Capital investment, next to the product demand, sales, and production costs, is one of the key metrics commonly used for project evaluation and feasibility assessment. Estimating the investment costs of a new product/process alternative during early-stage design is a challenging task, which is especially relevant in biorefinery research where information about new technologies and experience with new technologies is limited. A systematic methodology for uncertainty analysis of cost data is proposed that employs: (a) bootstrapping as a regression method when cost data are available; and, (b) the Monte Carlo technique as an error propagation method based on expert input when cost data are not available. Four well-known models for early-stage cost estimation are reviewed and analyzed using the methodology. The significance of uncertainties of cost data for early-stage process design is highlighted using the synthesis and design of a biorefinery as a case study. The impact of uncertainties in cost estimation on the identification of optimal processing paths is indeed found to be profound. To tackle this challenge, a comprehensive techno-economic risk analysis framework is presented to enable robust decision-making under uncertainties. One of the results using order-of-magnitude estimates shows that the production of diethyl ether and 1,3-butadiene are the most promising with the lowest economic risks (among the alternatives considered) of 0.24 MM$/a and 4.6 MM$/a, respectively.

  9. Research on Integration of NPP Operational Safety Management Performance Systems

    International Nuclear Information System (INIS)

    Chi, Miao; Shi, Liping

    2014-01-01

    The operational safety management of Nuclear Power Plants demands systematic planning and integrated control. NPPs are following the well-developed safety indicator systems proposed by IAEA Operational Safety Performance Indicator Programme, NRC Reactor Oversight Process or the other institutions. Integration of the systems is proposed to benefiting from the advantages of both systems and avoiding improper application into the real world. The authors analyzed the possibility and necessity for system integration, and propose an indicator system integrating method

  10. Top chemical opportunities from carbohydrate biomass: a chemist's view of the Biorefinery.

    Science.gov (United States)

    Dusselier, Michiel; Mascal, Mark; Sels, Bert F

    2014-01-01

    Cheap fossil oil resources are becoming depleted and crude oil prices are rising. In this context, alternatives to fossil fuel-derived carbon are examined in an effort to improve the security of carbon resources through the development of novel technologies for the production of chemicals, fuels, and materials from renewable feedstocks such as biomass. The general concept unifying the conversion processes for raw biomass is that of the biorefinery, which integrates biofuels with a selection of pivot points towards value-added chemical end products via so-called "platform chemicals". While the concept of biorefining is not new, now more than ever there is the motivation to investigate its true potential for the production of carbon-based products. A variety of renewable chemicals have been proposed by many research groups, many of them being categorized as drop-ins, while others are novel chemicals with the potential to displace petrochemicals across several markets. To be competitive with petrochemicals, carbohydrate-derived products should have advantageous chemical properties that can be profitably exploited, and/or their production should offer cost-effective benefits. The production of drop-ins will likely proceed in short term since the markets are familiar, while the commercial introduction of novel chemicals takes longer and demands more technological and marketing effort.Rather than describing elaborate catalytic routes and giving exhaustive lists of reactions, a large part of this review is devoted to creating a guideline for the selection of the most promising (platform) chemicals derived via chemical-catalytic reaction routes from lignocellulosic biomass. The major rationale behind our recommendations is a maximum conservation of functionality, alongside a high atom economy. Nature provides us with complex molecules like cellulose and hemicellulose, and it should be possible to transform them into chemical products while maintaining aspects of their

  11. Integrating authentic scientific research in a conservation course–based undergraduate research experience

    Science.gov (United States)

    Sorensen, Amanda E.; Corral, Lucia; Dauer, Jenny M.; Fontaine, Joseph J.

    2018-01-01

    Course-based undergraduate research experiences (CUREs) have been developed to overcome barriers including students in research. However, there are few examples of CUREs that take place in a conservation and natural resource context with students engaging in field research. Here, we highlight the development of a conservation-focused CURE integrated to a research program, research benefits, student self-assessment of learning, and perception of the CURE. With the additional data, researchers were able to refine species distribution models and facilitate management decisions. Most students reported gains in their scientific skills, felt they had engaged in meaningful, real-world research. In student reflections on how this experience helped clarify their professional intentions, many reported being more likely to enroll in graduate programs and seek employment related to science. Also interesting was all students reported being more likely to talk with friends, family, or the public about wildlife conservation issues after participating, indicating that courses like this can have effects beyond the classroom, empowering students to be advocates and translators of science. Field-based, conservation-focused CUREs can create meaningful conservation and natural resource experiences with authentic scientific teaching practices.

  12. Current Research at the Endeavour Ridge 2000 Integrated Studies Site

    Science.gov (United States)

    Butterfield, D. A.; Kelley, D. S.; Ridge 2000 Community, R.

    2004-12-01

    Integrated geophysical, geological, chemical, and biological studies are being conducted on the Endeavour segment with primary support from NSF, the W.M. Keck Foundation, and NSERC (Canada). The research includes a seismic network, physical and chemical sensors, high-precision mapping and time-series sampling. Several research expeditions have taken place at the Endeavour ISS in the past year. In June 2003, an NSF-sponsored cruise with R.V. al T.G.Thompson/ROV al Jason2 installed microbial incubators in drill-holes in the sides of active sulfide chimneys and sampled rocks, fluids, and microbes in the Mothra and Main Endeavour Field (MEF). In July 2003, with al Thompson/Jason2, an NSF-LEXEN project at Baby Bare on Endeavour east flank conducted sampling through seafloor-penetrating probes, plus time-series sampling of fluids, microbes, and rocks at the MEF. In September 2003, with al Thompson/ROV al ROPOS, the Keck Proto-Neptune project installed a seismic network consisting of 1 broadband and 7 short-period seismometers, installation of chemical/physical sensors and time-series samplers for chemistry and microbiology in the MEF and Clam Bed sites, collection of rocks, fluids, animals, and microbes. In May/June 2004, an NSF-sponsored al Atlantis/Alvin cruise recovered sulfide incubators installed in 2003, redeployed a sulfide incubator, mapped MEF and Mothra vent fields with high-resolution Imagenix sonar, sampled fluids from MEF, Mothra, and Clam Bed, recovered year-long time-series fluid and microbial samplers from MEF and Clam Bed, recovered and installed hot vent temperature-resistivity monitors, cleaned up the MEF and deployed new markers at major sulfide structures. In August 2004, there were two MBARI/Keck-sponsored cruises with R.V. al Western Flyer/ROV al Tiburon. The first cruise completed the seismic network with addition of two more broadband seismometers and serviced all 7 short-period seismometers. al Tiburon then performed microbial and chemical

  13. Environmental governance in Latin America: Towards an integrative research agenda

    Directory of Open Access Journals (Sweden)

    Michiel Baud

    2011-04-01

    Full Text Available Latin America plays an important international role with regard to environmental governance. Knowledge generated by empirical and theoretical studies on environmental challenges can support the renewed efforts to achieve equitable and sustainable natural resource use in the region. Although linkages between social and environmental dimensions have been academically explored since the 1990s, new trends in environmental governance in Latin America deserve a comprehensive analytical approach. This Exploration presents relevant emerging research topics and provides a brief overview of relevant elements and ‘cross-overs’ for an integrative analysis. The authors argue that in order to enhance ‘Latin American perspectives’ to solving socioenvironmental dilemmas, several research streams need to be brought together in integrative frameworks that can address complex questions related to interactions between state, civil society and market actors at multiple scales. With a consortium of ten Latin American and European institutions, they aim to contribute to the development of such frameworks through the project Environmental Governance in Latin America and the Caribbean: Developing Frameworks for Sustainable and Equitable Natural Resource Use (ENGOV.Resumen: Gobernanza ambiental en América Latina: Hacia un programa integrado de investigaciónAmérica Latina juega un importante papel internacional en el ámbito de la gobernanza ambiental. El conocimiento generado por estudios teóricos y empíricos sobre retos ambientales puede sostener renovados esfuerzos por llegar a un uso equitativo y sostenible de los recursos naturales en la región. Aunque las conexiones entre las dimensiones social y ambiental han sido estudiadas en la academia desde los años noventa, nuevas tendencias en gobernanza ambiental en América Latina merecen un enfoque analítico comprehensivo. Esta Exploración presenta nuevos y relevantes temas de investigación y ofrece una

  14. State-of-the-Art Report on Ethics of Research Integrity

    International Nuclear Information System (INIS)

    Kwon, Hyuk; Hahn, K. W.; Nam, Y. M.; You, B. H.; Min, B. J.

    2006-04-01

    The report briefly considers the generous ethical issues such as the background of philosophy, the issues of research ethics, the research integrity, the role of citation, the program and the code of research ethics. The report introduces the background of philosophy of science and elements of research ethics. It also considers the precedents of misconduct in research ethics and the ingredients to preserve the research integrity. Especially, the citation with obscure boundary between proper citation and plagiarism is carefully explored through several examples. Finally, the domestic ethics conditions are investigated on the research integrity and educational program on the responsible conduct of research. To compare the domestic situation, the educational program and the system of research integrity in EU and USA are deeply searched in Ch. 6 and Appendix III and V. To develop an educational program of research ethics and integrity, Nuclear Training Centre(NTC) collects and arranges the material and resource for research ethics

  15. State-of-the-Art Report on Ethics of Research Integrity

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Hyuk; Hahn, K. W.; Nam, Y. M.; You, B. H.; Min, B. J

    2006-04-15

    The report briefly considers the generous ethical issues such as the background of philosophy, the issues of research ethics, the research integrity, the role of citation, the program and the code of research ethics. The report introduces the background of philosophy of science and elements of research ethics. It also considers the precedents of misconduct in research ethics and the ingredients to preserve the research integrity. Especially, the citation with obscure boundary between proper citation and plagiarism is carefully explored through several examples. Finally, the domestic ethics conditions are investigated on the research integrity and educational program on the responsible conduct of research. To compare the domestic situation, the educational program and the system of research integrity in EU and USA are deeply searched in Ch. 6 and Appendix III and V. To develop an educational program of research ethics and integrity, Nuclear Training Centre(NTC) collects and arranges the material and resource for research ethics.

  16. Integrating Global Hydrology Into Graduate Engineering Education and Research

    Science.gov (United States)

    Griffis, V. W.

    2007-12-01

    Worldwide, polluted water affects the health of 1.2 billion people and contributes to the death of 15 million children under five every year. In addition poor environmental quality contributes to 25 per cent of all preventable ill health in the world. To address some of these problems, at the 2002 World Summit on Sustainable Development, the world community set the goal of halving, by the year 2015, the proportion of people without access to safe drinking water and basic sanitation. Solving sanitation and water resource management problems in any part of the world presents an interdisciplinary, complex challenge. However, when we attempt to solve these problems in an international context, our technical approaches must be tempered with cultural sensitivity and extraordinary management strategies. To meet this challenge, Michigan Tech has developed a unique global partnership with the U.S. Peace Corps to address our acknowledgement of the importance of placing engineering solutions in a global context. The program has graduated 30 students. Program enrollment is now over 30 and over 20 countries have hosted our students. The objective of this presentation is to demonstrate how this unique partnership can be integrated with graduate engineering education and research and also show how such a program may attract a more diverse student population into engineering. All graduate students enrolled in our Master's International Program in Civil and Environmental Engineering must complete specific coursework requirements before departing for their international experience. In CE5993 (Field Engineering in the Developing World) students learn to apply concepts of sustainable development and appropriate technology in the developing world. In FW5770 (Rural Community Development Planning and Analysis) students learn how one involves a community in the decision making process. A common theme in both courses is the role of woman in successful development projects. Technical

  17. Translational toxicology: a developmental focus for integrated research strategies.

    Science.gov (United States)

    Hughes, Claude; Waters, Michael; Allen, David; Obasanjo, Iyabo

    2013-09-30

    Given that toxicology studies the potential adverse effects of environmental exposures on various forms of life and that clinical toxicology typically focuses on human health effects, what can and should the relatively new term of "translational toxicology" be taken to mean? Our assertion is that the core concept of translational toxicology must incorporate existing principles of toxicology and epidemiology, but be driven by the aim of developing safe and effective interventions beyond simple reduction or avoidance of exposure to prevent, mitigate or reverse adverse human health effects of exposures.The field of toxicology has now reached a point where advances in multiple areas of biomedical research and information technologies empower us to make fundamental transitions in directly impacting human health. Translational toxicology must encompass four action elements as follows: 1) Assessing human exposures in critical windows across the lifespan; 2) Defining modes of action and relevance of data from animal models; 3) Use of mathematical models to develop plausible predictions as the basis for: 4) Protective and restorative human health interventions. The discussion focuses on the critical window of in-utero development. Exposure assessment, basic toxicology and development of certain categories of mathematical models are not new areas of research; however overtly integrating these in order to conceive, assess and validate effective interventions to mitigate or reverse adverse effects of environmental exposures is our novel opportunity. This is what we should do in translational toxicology so that we have a portfolio of interventional options to improve human health that include both minimizing exposures and specific preventative/restorative/mitigative therapeutics.

  18. Integrated technology rotor/flight research rotor concept definition study

    Science.gov (United States)

    Carlson, R. G.; Beno, E. A.; Ulisnik, H. D.

    1983-01-01

    As part of the Integrated Technology Rotor/Flight Research Rotor (ITR/FRR) Program a number of advanced rotor system designs were conceived and investigated. From these, several were chosen that best meet the started ITR goals with emphasis on stability, reduced weight and hub drag, simplicity, low head moment stiffness, and adequate strength and fatigue life. It was concluded that obtaining low hub moment stiffness was difficult when only the blade flexibility of bearingless rotor blades is considered, unacceptably low fatigue life being the primary problem. Achieving a moderate hub moment stiffness somewhat higher than state of the art articulated rotors in production today is possible within the fatigue life constraint. Alternatively, low stiffness is possible when additional rotor elements, besides the blades themselves, provide part of the rotor flexibility. Two primary designs evolved as best meeting the general ITR requirements that presently exist. An I shaped flexbeam with an external torque tube can satisfy the general goals but would have either higher stiffness or reduced fatigue life. The elastic gimbal rotor can achieve a better combination of low stiffness and high fatigue life but would be a somewhat heavier design and possibly exhibit a higher risk of aeromechanical instability.

  19. Making the Move: A Mixed Research Integrative Review

    Directory of Open Access Journals (Sweden)

    Sarah Gilbert

    2015-08-01

    Full Text Available The purpose of this mixed research integrative review is to determine factors that influence relocation transitions for older adults who are considering a move from independent living to supervised housing, such as assisted living, using the Theory of Planned Behavior as a conceptual guide. PubMED, CINAHL, and PsychInfo databases were queried using key words: relocation, transition, older adults, and, elderly and time limited from 1992 to 2014. Sixteen articles were retained for review. The majority of articles, qualitative in design, reveal that older adults who comprehend the need to move and participate in the decision-making process of a relocation adjust to new living environments with fewer negative outcomes than older adults who experience a forced relocation. The few quantitative articles examined the elements of impending relocation using a variety of instruments but support the necessity for older adults to recognize the possibility of a future move and contribute to the relocation process. Additionally, the influence of family, friends, and health care providers provides the older adult with support and guidance throughout the process.

  20. Phase 2 of the International Piping Integrity Research Group programme

    International Nuclear Information System (INIS)

    Darlaston, B.J.

    1994-01-01

    The results of phase 1 of the International Piping Integrity Research Group (IPIRG-1) programme have been widely reported. The significance of the results is reviewed briefly, in order to put the phase 2 programme into perspective. The success of phase 1 led the participants to consider further development and validation of pipe and pipe component fracture analysis technology as part of another international group programme (IPIRG-2). The benefits of combined funding and of the technical exchanges and interactions are considered to be of significant advantage and value. The phase 2 programme has been designed with the overall objective of developing and experimentally validating methods of predicting the fracture behaviour of nuclear reactor safety-related piping, to both normal operating and accident loads. The programme will add to the engineering estimation analysis methods that have been developed for straight pipes. The pipe system tests will expand the database to include seismic loadings and flaws in fittings, such as bends, elbows and tees, as well as ''short'' cracks. The results will be used to validate further the analytical methods, expand the capability to make fittings and extend the quasi-static results for the USNRC's new programme on short cracks in piping and piping welds. The IPIRG-2 programme is described to provide a clear understanding of the content, strategy, potential benefits and likely significance of the work. ((orig.))

  1. Research integrity: the experience of a doubting Thomas.

    Science.gov (United States)

    Hettinger, Thomas P

    2014-04-01

    The sensational "reactome array" paper published in Science in 2009 was investigated in Spain by the Ethics Committee of Consejo Superior de Investigaciones Cientificas (CSIC) after Science issued an editorial expression of concern. The paper was retracted in 2010 because of "skepticism" due to "errors" in chemistry. The "errors" were so profound that many readers expressed doubt that they were really errors, but part of an elaborate hoax. I conducted a forensic analysis of mass spectrometry data in the paper's Supporting Online Material (SOM) and was able to prove that thousands of data values were in fact fabricated. The SOM contains signatures of improper extensive spreadsheet manipulations of incorrect atomic and molecular mass values as well as impossibly repetitive deviations of found molecular mass values from their expected values. No evidence of real mass spectrometry data was detected. Both CSIC and Science have been content to retract the paper without acknowledging the fabrications or assigning responsibility for them. Neither CSIC nor Science has expressed interest in having an independent investigation determining how the paper came to be written, reviewed and published. Their weak response to this episode is a daunting signal that there is an impending crisis in research integrity and science journalism.

  2. Gender integration in coeducational classrooms: Advancing educational research and practice.

    Science.gov (United States)

    Fabes, Richard A; Martin, Carol Lynn; Hanish, Laura D; DeLay, Dawn

    2018-06-01

    Despite the fact that most boys and girls are in classrooms together, there is considerable variation in the degree to which their classrooms reflect gender integration (GI). In some classrooms, boys' and girls' relationships with each other are generally positive and harmonious. However, in other classes, students tend to only work with classmates of the same gender (i.e., gender segregation, GS), and cross-gender interactions seldom occur or, when they do, they may not be positive. As such, the coeducational context of schools provides no assurance that boys and girls work effectively together to learn, solve academic problems, and support one another in their academic efforts. The purpose of this perspective paper is to call attention to the importance of studying and understanding the role of GI in contemporary U.S. coeducational classrooms. Some of the costs associated with the failure to consider GI also are identified, as are implications for future research and educational practice. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  3. Brazilian research about prevention of cervical neoplasia: an integrative review

    Directory of Open Access Journals (Sweden)

    Jaqueline Apolônio de Freitas Guimarães

    2012-04-01

    Full Text Available This is an integrative review that aimed to synthesize the scientific knowledge published in national nursing journals about the prevention of cervical cancer. It was made a literature review in May 2009 in BIREME, covering the national nursing publications, from 1999 to 2009. We identified 15 articles that comprised the study sample. Of these, 11 addressed the nursing care, 6 were about prevention of cancer and 5 were about risk factors for such disease. In 4 articles the studies were accomplished in the Family Health Care Unit (UBASF which was the most prevalent place. It was found out that 6 of the articles used the qualitative method. The most studied population was formed by users of the Family Health Care Unit, in 3 studies. It was so concluded that the national research about this topic was related to the problems identified in health places, either in the effectiveness of the examination, in the knowledge of users or in conducted health education.

  4. Integrated Knowledge Translation and Grant Development: Addressing the Research Practice Gap through Stakeholder-informed Research.

    Science.gov (United States)

    Henderson, Joanna; Brownlie, Elizabeth; Rosenkranz, Susan; Chaim, Gloria; Beitchman, Joseph

    2013-11-01

    We describe our stakeholder engagement process for grant application development that occurred as part of our integrated knowledge translation plan and make recommendations for researchers. In phase 1, a stakeholder consultation group was developed. In phase 2, surveys regarding knowledge gathering, research agenda, and research collaboration preferences were sent to 333 cross-sectoral youth-serving organizations in Ontario, including family and consumer organizations. In phase 1, 28 stakeholders from six sectors participated in the consultation group and provided input on multiple aspects of the proposal. Through this process, 19 stakeholders adopted formal roles within the project. In phase 2, 206 surveys were received (response rate = 62%). Survey responses supported the grant focus (concurrent youth mental health and substance use problems). Respondents also prioritized project goals and provided specific feedback on research and knowledge translation. Finally, although some stakeholders chose greater involvement, most survey respondents indicated a preference for a moderate level of participation in research rather than full team membership. Despite short timelines and feasibility challenges, stakeholders can be meaningfully engaged in and contribute to the grant proposal development process. Consideration is needed for the practical challenges that stakeholder organizations face in supporting and participating in research.

  5. Wallowa County Integrated Biomass Energy Center

    Energy Technology Data Exchange (ETDEWEB)

    Christoffersen, Nils [Wallowa Resources Community Solutions Inc., Wallowa, OR (United States)

    2014-05-02

    The Integrated Biomass Energy Center (IBEC) is an approximately 0.1 MW CHP integrated biorefinery in Northeastern Oregon which will demonstrate and validate small-scale combined heat and power from lignin intermediates/residues. IBEC will be co-located with feedstock suppliers and thermal and power customers for distributed generation. The project was developed by Wallowa Resources Community Solutions Inc.

  6. Succinic Acid as a Byproduct in a Corn-based Ethanol Biorefinery

    Energy Technology Data Exchange (ETDEWEB)

    MBI International

    2007-12-31

    MBI endeavored to develop a process for succinic acid production suitable for integration into a corn-based ethanol biorefinery. The project investigated the fermentative production of succinic acid using byproducts of corn mill operations. The fermentation process was attuned to include raw starch, endosperm, as the sugar source. A clean-not-sterile process was established to treat the endosperm and release the monomeric sugars. We developed the fermentation process to utilize a byproduct of corn ethanol fermentations, thin stillage, as the source of complex nitrogen and vitamin components needed to support succinic acid production in A. succinogenes. Further supplementations were eliminated without lowering titers and yields and a productivity above 0.6 g l-1 hr-1was achieved. Strain development was accomplished through generation of a recombinant strain that increased yields of succinic acid production. Isolation of additional strains with improved features was also pursued and frozen stocks were prepared from enriched, characterized cultures. Two recovery processes were evaluated at pilot scale and data obtained was incorporated into our economic analyses.

  7. Status of integrated multidisciplinary rotorcraft optimization research at the Langley Research Center

    Science.gov (United States)

    Mantay, Wayne R.; Adelman, Howard M.

    1990-01-01

    This paper describes a joint NASA/Army research activity at the Langley Research Center to develop optimization procedures aimed at improving the rotor blade design process by integrating appropriate disciplines and accounting for important interactions among the disciplines. The activity is being guided by a Steering Committee made up of key NASA and Army researchers and managers. The paper describes the optimization formulation in terms of the objective function, design variables, and constraints. The analysis aspects are discussed, and the interdisciplinary interactions are defined in terms of the information that must be transferred among disciplinary analyses as well as the trade-offs between disciplines in determining the details of the design. At this writing, some significant progress has been made. Results given in the paper represent accomplishments in rotor aerodynamic performance optimization for minimum horsepower, rotor dynamic optimization for vibration reduction, approximate analysis of frequencies and mode shapes, rotor structural optimization for minimum weight, and integrated aerodynamic load/dynamics optimization for minimum vibration and weight.

  8. Differing Perceptions Concerning Research Integrity Between Universities and Industry: A Qualitative Study.

    Science.gov (United States)

    Godecharle, Simon; Nemery, Benoit; Dierickx, Kris

    2017-09-14

    Despite the ever increasing collaboration between industry and universities, the previous empirical studies on research integrity and misconduct excluded participants of biomedical industry. Hence, there is a lack of empirical data on how research managers and biomedical researchers active in industry perceive the issues of research integrity and misconduct, and whether or not their perspectives differ from those of researchers and research managers active in universities. If various standards concerning research integrity and misconduct are upheld between industry and universities, this might undermine research collaborations. Therefore we performed a qualitative study by conducting 22 semi-structured interviews in order to investigate and compare the perspectives and attitudes concerning the issues of research integrity and misconduct of research managers and biomedical researchers active in industry and universities. Our study showed clear discrepancies between both groups. Diverse strategies in order to manage research misconduct and to stimulate research integrity were observed. Different definitions of research misconduct were given, indicating that similar actions are judged heterogeneously. There were also differences at an individual level, whether the interviewees were active in industry or universities. Overall, the management of research integrity proves to be a difficult exercise, due to many diverse perspectives on several essential elements connected to research integrity and misconduct. A management policy that is not in line with the vision of the biomedical researchers and research managers is at risk of being inefficient.

  9. Potential of bioethanol as a chemical building block for biorefineries: preliminary sustainability assessment of 12 bioethanol-based products.

    Science.gov (United States)

    Posada, John A; Patel, Akshay D; Roes, Alexander; Blok, Kornelis; Faaij, André P C; Patel, Martin K

    2013-05-01

    The aim of this study is to present and apply a quick screening method and to identify the most promising bioethanol derivatives using an early-stage sustainability assessment method that compares a bioethanol-based conversion route to its respective petrochemical counterpart. The method combines, by means of a multi-criteria approach, quantitative and qualitative proxy indicators describing economic, environmental, health and safety and operational aspects. Of twelve derivatives considered, five were categorized as favorable (diethyl ether, 1,3-butadiene, ethyl acetate, propylene and ethylene), two as promising (acetaldehyde and ethylene oxide) and five as unfavorable derivatives (acetic acid, n-butanol, isobutylene, hydrogen and acetone) for an integrated biorefinery concept. Copyright © 2012 Elsevier Ltd. All rights reserved.

  10. Investigation of uncertainties associated with the production of n-butanol through ethanol catalysis in sugarcane biorefineries.

    Science.gov (United States)

    Pereira, Lucas G; Dias, Marina O S; MacLean, Heather L; Bonomi, Antonio

    2015-08-01

    This study evaluated the viability of n-butanol production integrated within a first and second generation sugarcane biorefinery. The evaluation included a deterministic analysis as well as a stochastic approach, the latter using Monte Carlo simulation. Results were promising for n-butanol production in terms of revenues per tonne of processed sugarcane, but discouraging with respect to internal rate of return (IRR). The uncertainty analysis determined there was high risk involved in producing n-butanol and co-products from ethanol catalysis. It is unlikely that these products and associated production route will be financially attractive in the short term without lower investment costs, supportive public policies and tax incentives coupled with biofuels' production strategies. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Fostering integrity in postgraduate research: an evidence-based policy and support framework.

    Science.gov (United States)

    Mahmud, Saadia; Bretag, Tracey

    2014-01-01

    Postgraduate research students have a unique position in the debate on integrity in research as students and novice researchers. To assess how far policies for integrity in postgraduate research meet the needs of students as "research trainees," we reviewed online policies for integrity in postgraduate research at nine particular Australian universities against the Australian Code for Responsible Conduct of Research (the Code) and the five core elements of exemplary academic integrity policy identified by Bretag et al. (2011 ), i.e., access, approach, responsibility, detail, and support. We found inconsistency with the Code in the definition of research misconduct and a lack of adequate detail and support. Based on our analysis, previous research, and the literature, we propose a framework for policy and support for postgraduate research that encompasses a consistent and educative approach to integrity maintained across the university at all levels of scholarship and for all stakeholders.

  12. A Triangular Approach to Integrate Research, Education and Practice in Higher Engineering Education

    Science.gov (United States)

    Heikkinen, Eetu-Pekka; Jaako, Juha; Hiltunen, Jukka

    2017-01-01

    Separate approaches in engineering education, research and practice are not very useful when preparing students for working life; instead, integration of education, research and industrial practices is needed. A triangular approach (TA) as a method to accomplish this integration and as a method to provide students with integrated expertise is…

  13. Perceptions That Influence the Maintenance of Scientific Integrity in Community-Based Participatory Research

    Science.gov (United States)

    Kraemer Diaz, Anne E.; Spears Johnson, Chaya R.; Arcury, Thomas A.

    2015-01-01

    Scientific integrity is necessary for strong science; yet many variables can influence scientific integrity. In traditional research, some common threats are the pressure to publish, competition for funds, and career advancement. Community-based participatory research (CBPR) provides a different context for scientific integrity with additional and…

  14. Design of a biomass-to-biorefinery logistics system through bio-inspired metaheuristic optimization considering multiple types of feedstocks

    Science.gov (United States)

    Trueba, Isidoro

    fossil fuels to biofuels. In many ways biomass is a unique renewable resource. It can be stored and transported relatively easily in contrast to renewable options such as wind and solar, which create intermittent electrical power that requires immediate consumption and a connection to the grid. This thesis presents two different models for the design optimization of a biomass-to-biorefinery logistics system through bio-inspired metaheuristic optimization considering multiple types of feedstocks. This work compares the performance and solutions obtained by two types of metaheuristic approaches; genetic algorithm and ant colony optimization. Compared to rigorous mathematical optimization methods or iterative algorithms, metaheuristics do not guarantee that a global optimal solution can be found on some class of problems. Problems with similar characteristics to the one presented in this thesis have been previously solved using linear programming, integer programming and mixed integer programming methods. However, depending on the type of problem, these mathematical or complete methods might need exponential computation time in the worst-case. This often leads to computation times too high for practical purposes. Therefore, this thesis develops two types of metaheuristic approaches for the design optimization of a biomass-to-biorefinery logistics system considering multiple types of feedstocks and shows that metaheuristics are highly suitable to solve hard combinatorial optimization problems such as the one addressed in this research work.

  15. Integrative Genomics Viewer (IGV) | Informatics Technology for Cancer Research (ITCR)

    Science.gov (United States)

    The Integrative Genomics Viewer (IGV) is a high-performance visualization tool for interactive exploration of large, integrated genomic datasets. It supports a wide variety of data types, including array-based and next-generation sequence data, and genomic annotations.

  16. Integrated Marketing in Higher Education. Research Report 01-01.

    Science.gov (United States)

    Morris, L. Michelle; Cejda, Brent D.

    Integrated marketing deals with aspects often referred to as the "4 Ps": product, price, place, and promotion. These aspects have also been described as the "4 Cs": customer, cost, convenience, and communication. Integrated marketing has been defined as "a listening-first, database-dependent approach to marketing that includes both a willingness…

  17. An exploration of knowledge integration problems in interdisciplinary research teams

    NARCIS (Netherlands)

    Bayerl, P.S.; Steinheider, B.

    2009-01-01

    The integration of function-specific expertise into a shared knowledge base is a crucial, but complex process for success in interdisciplinary teams. This paper presents an empirically derived typology of knowledge integration problems and links their occurrence to degree of heterogeneity and

  18. Fuel tank integrity research : fuel tank analyses and test plans

    Science.gov (United States)

    2013-04-15

    The Federal Railroad Administrations Office of Research : and Development is conducting research into fuel tank : crashworthiness. Fuel tank research is being performed to : determine strategies for increasing the fuel tank impact : resistance to ...

  19. Conversion of Indigenous Agricultural Waste Feedstocks to Fuel Ethanol. Cooperative Research and Development Final Report, CRADA Number CRD-13-504

    Energy Technology Data Exchange (ETDEWEB)

    Elander, Richard [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-03-27

    This Cooperative Research and Development Agreement (CRADA) is between the National Renewable Energy Laboratory (NREL), a world leader in biomass conversion research and Ecopetrol American Inc., Ecopetrol S.A.'s U.S. subsidiary. The research and development efforts described in the Joint Work Statement (JWS) will take advantage of the strengths of both parties. NREL will use its Integrated Biorefinery Facility and vast experience in the conversion of lignocellulosic feedstocks to fuel ethanol to develop processes for the conversion of Ecopetrol's feedstocks. Ecopetrol will establish the infrastructure in Columbia to commercialize the conversion process.

  20. Methylation Integration (Mint) | Informatics Technology for Cancer Research (ITCR)

    Science.gov (United States)

    A comprehensive software pipeline and set of Galaxy tools/workflows for integrative analysis of genome-wide DNA methylation and hydroxymethylation data. Data types can be either bisulfite sequencing and/or pull-down methods.

  1. Improving Energy Efficiency and Enabling Water Recycle in Biorefineries Using Bioelectrochemical Cells

    International Nuclear Information System (INIS)

    Borole, Abhijeet P.

    2010-01-01

    Improving biofuel yield and water reuse are two important issues in further development of biorefineries. The total energy content of liquid fuels (including ethanol and hydrocarbon) produced from cellulosic biomass via biochemical or hybrid bio-thermochemical routes can vary from 49% to 70% of the biomass entering the biorefinery, on an energy basis. Use of boiler for combustion of residual organics and lignin results in significant energy and water losses. An alternate process to improve energy recovery from the residual organic streams is via use of bioelectrochemical systems such as microbial fuel cells (MFCs) microbial electrolysis cells (MECs). The potential advantages of this alternative scheme in a biorefinery include minimization of heat loss and generation of a higher value product, hydrogen. The need for 5-15 gallons of water per gallon of ethanol can be reduced significantly via recycle of water after MEC treatment. Removal of inhibitory byproducts such as furans, phenolics and acetate in MFC/MECs to generate energy, thus, has dual advantages including improvements in energy efficiency and ability to recycle water. Conversion of the sugar- and lignin- degradation products to hydrogen is synergistic with biorefinery hydrogen requirements for upgrading F-T liquids and other byproducts to high-octane fuels and/or high value products. Some of these products include sorbitol, succinic acid, furan and levulinate derivatives, glycols, polyols, 1,4-butenadiol, phenolics polymers, etc. Potential process alternatives utilizing MECs in biorefineries capable of improving energy efficiency by up to 30% are discussed.

  2. Research on psychotherapy integration: building on the past, looking to the future.

    Science.gov (United States)

    Castonguay, Louis G; Eubanks, Catherine F; Goldfried, Marvin R; Muran, J Christopher; Lutz, Wolfgang

    2015-01-01

    Integration has become an important and influential movement within psychotherapy practice, reflected by the fact that many treatment providers now identify as integrative. However, integration has not had as great an influence on psychotherapy research. The goal of this paper is to highlight the growing body of research on psychotherapy integration, and to identify future directions for research that may strengthen the integration movement as well as the field of psychotherapy as a whole. We first summarize the past 25 years of research on integration, with a focus on four approaches to integration: theoretical integration, technical eclectic, common factors, and assimilative integration. Next, we identify directions of research within these four areas that could strengthen and support integrative practice. We then propose ways in which the perspective of integrationists could contribute to psychotherapy research in the critical areas of harmful effects, therapist effects, practice-oriented research, and training. We end this paper by suggesting that a greater collaboration between integrationists and psychotherapy researchers will help to create a unified landscape of knowledge and action that will benefit all participants and advance the field.

  3. A GENERIC TACTICAL PLANNING MODEL TO SUPPLY A BIOREFINERY WITH BIOMASS

    Directory of Open Access Journals (Sweden)

    Birome Holo Ba

    Full Text Available ABSTRACT The supply chains which bring biomass to biorefineries play a critical role in biofuel production. Optimization models can help decision makers to design more efficient chains and minimize the cost of biomass delivered to the refineries. This article based on a French national research project on biomass logistics considers one refinery, able to process several crops and several parts of the same crop, over a one-year horizon divided into days or weeks. A network model and a data model are first developed to let the decision maker describe the supply chain structure and its data, without affecting the underlying mathematical model. The latter is a mixed integer linear program which combines for the first time various features, either original or tackled separately in the literature. Knowing the refinery demands, it determines the activity levels in the network (amounts harvested, baled, transported, stored, etc. and the required equipment, in order to minimize a total cost including harvesting costs, transport costs and storage costs. Numerical evaluations based on real data show that the proposed model can optimize large supply chains in reasonable running times.

  4. From gene to biorefinery: microbial β-etherases as promising biocatalysts for lignin valorization

    Directory of Open Access Journals (Sweden)

    Pere ePicart

    2015-09-01

    Full Text Available The set-up of biorefineries for the valorization of lignocellulosic biomass will be core in the future to reach sustainability targets. In this area, biomass-degrading enzymes are attracting significant research interest for their potential in the production of chemicals and biofuels from renewable feedstock. Gluthatione-dependent β-etherases are emerging enzymes for the biocatalytic depolymerization of lignin, a heterogeneous aromatic polymer abundant in Nature. They selectively catalyze the reductive cleavage of β-O-4 aryl-ether bonds which account for 45-60% of linkages present in lignin. Hence, application of β-etherases in lignin depolymerization would enable a specific lignin breakdown, selectively yielding (valuable low-molecular-mass aromatics. Albeit β-etherases have been biochemically known for decades, only very recently novel β-etherases have been identified and thoroughly characterized for lignin valorization, expanding the enzyme toolbox for efficient β-O-4 aryl-ether bond cleavage. Given their emerging importance and potential, this mini-review discusses recent developments in the field of β-etherase biocatalysis covering all aspects from enzyme identification to biocatalytic applications with real lignin samples.

  5. From gene to biorefinery: microbial β-etherases as promising biocatalysts for lignin valorization.

    Science.gov (United States)

    Picart, Pere; de María, Pablo Domínguez; Schallmey, Anett

    2015-01-01

    The set-up of biorefineries for the valorization of lignocellulosic biomass will be core in the future to reach sustainability targets. In this area, biomass-degrading enzymes are attracting significant research interest for their potential in the production of chemicals and biofuels from renewable feedstock. Glutathione-dependent β-etherases are emerging enzymes for the biocatalytic depolymerization of lignin, a heterogeneous aromatic polymer abundant in nature. They selectively catalyze the reductive cleavage of β-O-4 aryl-ether bonds which account for 45-60% of linkages present in lignin. Hence, application of β-etherases in lignin depolymerization would enable a specific lignin breakdown, selectively yielding (valuable) low-molecular-mass aromatics. Albeit β-etherases have been biochemically known for decades, only very recently novel β-etherases have been identified and thoroughly characterized for lignin valorization, expanding the enzyme toolbox for efficient β-O-4 aryl-ether bond cleavage. Given their emerging importance and potential, this mini-review discusses recent developments in the field of β-etherase biocatalysis covering all aspects from enzyme identification to biocatalytic applications with real lignin samples.

  6. Hydrothermal Liquefaction of Agricultural and Biorefinery Residues Final Report – CRADA #PNNL/277

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, Douglas C.; Neuenschwander, Gary G.; Hart, Todd R.; Rotness, Leslie J.; Zacher, Alan H.; Fjare, K. A.; Dunn, B. C.; McDonald, S. L.; Dassor, G.

    2010-07-28

    This project was performed as a Cooperative Research and Development Agreement (CRADA) with the participants: Archer-Daniels-Midland Company (ADM), ConocoPhillips (COP), and Pacific Northwest National Laboratory (PNNL). Funding from the federal government was provided by the Office of the Biomass Program within the Energy Efficiency and Renewable Energy assistant secretariat as part of the Thermochemical Conversion Platform. The three-year project was initiated in August 2007 with formal signing of the CRADA (#PNNL/277) in March 3, 2008 with subsequent amendments approved in November of 2008 and August of 2009. This report describes the results of the work performed by PNNL and the CRADA partners ADM and COP. It is considered Protected CRADA Information and is not available for public disclosure. The work conducted during this project involved developing process technology at PNNL for hydrothermal liquefaction (HTL) of agricultural and biorefinery residues and catalytic hydrothermal gasification (CHG) of the aqueous byproduct from the liquefaction step. Related work performed by the partners included assessment of aqueous phase byproducts, hydroprocessing of the bio-oil product and process analysis and economic modeling of the technology.

  7. Variation in the Interpretation of Scientific Integrity in Community-based Participatory Health Research

    Science.gov (United States)

    Kraemer Diaz, Anne E.; Spears Johnson, Chaya R.; Arcury, Thomas A.

    2013-01-01

    Community-based participatory research (CBPR) has become essential in health disparities and environmental justice research; however, the scientific integrity of CBPR projects has become a concern. Some concerns, such as appropriate research training, lack of access to resources and finances, have been discussed as possibly limiting the scientific integrity of a project. Prior to understanding what threatens scientific integrity in CBPR, it is vital to understand what scientific integrity means for the professional and community investigators who are involved in CBPR. This analysis explores the interpretation of scientific integrity in CBPR among 74 professional and community research team members from of 25 CBPR projects in nine states in the southeastern United States in 2012. It describes the basic definition for scientific integrity and then explores variations in the interpretation of scientific integrity in CBPR. Variations in the interpretations were associated with team member identity as professional or community investigators. Professional investigators understood scientific integrity in CBPR as either conceptually or logistically flexible, as challenging to balance with community needs, or no different than traditional scientific integrity. Community investigators interpret other factors as important in scientific integrity, such as trust, accountability, and overall benefit to the community. This research demonstrates that the variations in the interpretation of scientific integrity in CBPR call for a new definition of scientific integrity in CBPR that takes into account the understanding and needs of all investigators. PMID:24161098

  8. The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging.

    Science.gov (United States)

    Ladiges, Warren; Ikeno, Yuji; Niedernhofer, Laura; McIndoe, Richard A; Ciol, Marcia A; Ritchey, Jerry; Liggitt, Denny

    2016-04-01

    Geropathology is the study of aging and age-related lesions and diseases in the form of whole necropsies/autopsies, surgical biopsies, histology, and molecular biomarkers. It encompasses multiple subspecialties of geriatrics, anatomic pathology, molecular pathology, clinical pathology, and gerontology. In order to increase the consistency and scope of communication in the histologic and molecular pathology assessment of tissues from preclinical and clinical aging studies, a Geropathology Research Network has been established consisting of pathologists and scientists with expertise in the comparative pathology of aging, the design of aging research studies, biostatistical methods for analysis of aging data, and bioinformatics for compiling and annotating large sets of data generated from aging studies. The network provides an environment to promote learning and exchange of scientific information and ideas for the aging research community through a series of symposia, the development of uniform ways of integrating pathology into aging studies, and the statistical analysis of pathology data. The efforts of the network are ultimately expected to lead to a refined set of sentinel biomarkers of molecular and anatomic pathology that could be incorporated into preclinical and clinical aging intervention studies to increase the relevance and productivity of these types of investigations. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  9. Prospective evaluation for the sugar cane factory transformation in biorefinery

    International Nuclear Information System (INIS)

    Rodríguez Plaza, Rocío; Armas Martínez, Ana Celia de; Rodríguez Carvajal, Lily Elena; García Orozco, Yamila; Torres, Alfredo

    2015-01-01

    The present work has as goal to evaluate prospectively alternative of transformation in the '5 de Septiembre' sugar industry, located in Cienfuegos, for a superfine alcohol biorefinery. Two alternatives were taking into account; the first one was the installation of a distillery for a capacity of 500 hl/d of superfine alcohol, using the molasses and 10% of the filters juice coming from the sugar mill, as complement of the stage of fermentation, and also a plant of biodiesel production starting from microalgae biomass and of mud separated in the sugar mill and another installation of a distillery for a similar capacity of 500 Hl/d of superfine ethanol using molasses, the filters juices and microalgae hydrolysate. For the second alternative, it intends a distillery where saving of 67 % for the molasses, and 22.73 % for the water, these results are experimentally obtained. The most feasible alternative obtain 5 years of payback period, 21 % of an IRR and U$D 37104 419.21 of NPV. (author)

  10. Ionizing radiation and a wood-based biorefinery

    International Nuclear Information System (INIS)

    Driscoll, Mark S.; Stipanovic, Arthur J.; Cheng, Kun; Barber, Vincent A.; Manning, Mellony; Smith, Jennifer L.; Sundar, Smith

    2014-01-01

    Woody biomass is widely available around the world. Cellulose is the major structural component of woody biomass and is the most abundant polymer synthesized by nature, with hemicellulose and lignin being second and third. Despite this great abundance, woody biomass has seen limited application outside of the paper and lumber industries. Its use as a feedstock for fuels and chemicals has been limited because of its highly crystalline structure, inaccessible morphology, and limited solubility (recalcitrance). Any economic use of woody biomass for the production of fuels and chemicals requires a “pretreatment” process to enhance the accessibility of the biomass to enzymes and/or chemical reagents. Electron beams (EB), X-rays, and gamma rays produce ions in a material which can then initiate chemical reactions and cleavage of chemical bonds. Such ionizing radiation predominantly scissions and degrades or depolymerizes both cellulose and hemicelluloses, less is known about its effects on lignin. This paper discusses how ionizing radiation can be used to make a wood-based biorefinery more environmentally friendly and profitable for its operators. - Highlights: • Ionizing radiation reduces the crystallinity of cellulose. • Ionizing radiation reduces cellulose's degree of polymerization. • The amount and rate of enzymatic hydrolysis of lignocellulosic materials, including wood, are increased with increasing radiation dose. • Wood and other lignocellulosic materials have the potential to be a renewable material for the production of chemicals and fuels

  11. Effects of Disruption Risks on Biorefinery Location Design

    Directory of Open Access Journals (Sweden)

    Yun Bai

    2015-02-01

    Full Text Available While ever-growing bio-ethanol production poses considerable challenges to the bioenergy supply chain, the risk of refinery operation disruptions further compromises the efficiency and reliability of the energy supply system. This paper applies discrete and continuous reliable facility location models to the design of reliable bio-ethanol supply chains so that the system can hedge against potential operational disruptions. The discrete model is shown to be suitable for obtaining the exact optimality for small or moderate instances, while the continuous model has superior computational tractability for large-scale applications. The impacts of both site-independent and dependent disruptions (i.e., due to flooding are analyzed in empirical case study for the State of Illinois (one of the main biomass supply states in the U.S.. The reliable solution is compared with a deterministic solution under the same setting. It is found that refinery disruptions, especially those site-dependent ones, affect both optimal refinery deployment and the supply chain cost. Sensitivity analysis is also conducted to show how refinery failure probability and fixed cost (for building biorefineries affect optimal supply chain configuration and the total expected system cost.

  12. Reviving the carbohydrate economy via multi-product lignocellulose biorefineries.

    Science.gov (United States)

    Zhang, Y-H Percival

    2008-05-01

    Before the industrial revolution, the global economy was largely based on living carbon from plants. Now the economy is mainly dependent on fossil fuels (dead carbon). Biomass is the only sustainable bioresource that can provide sufficient transportation fuels and renewable materials at the same time. Cellulosic ethanol production from less costly and most abundant lignocellulose is confronted with three main obstacles: (1) high processing costs (dollars /gallon of ethanol), (2) huge capital investment (dollars approximately 4-10/gallon of annual ethanol production capacity), and (3) a narrow margin between feedstock and product prices. Both lignocellulose fractionation technology and effective co-utilization of acetic acid, lignin and hemicellulose will be vital to the realization of profitable lignocellulose biorefineries, since co-product revenues would increase the margin up to 6.2-fold, where all purified lignocellulose co-components have higher selling prices (> approximately 1.0/kg) than ethanol ( approximately 0.5/kg of ethanol). Isolation of large amounts of lignocellulose components through lignocellulose fractionation would stimulate R&D in lignin and hemicellulose applications, as well as promote new markets for lignin- and hemicellulose-derivative products. Lignocellulose resource would be sufficient to replace significant fractionations (e.g., 30%) of transportation fuels through liquid biofuels, internal combustion engines in the short term, and would provide 100% transportation fuels by sugar-hydrogen-fuel cell systems in the long term.

  13. Zymomonas mobilis: a novel platform for future biorefineries.

    Science.gov (United States)

    He, Ming Xiong; Wu, Bo; Qin, Han; Ruan, Zhi Yong; Tan, Fu Rong; Wang, Jing Li; Shui, Zong Xia; Dai, Li Chun; Zhu, Qi Li; Pan, Ke; Tang, Xiao Yu; Wang, Wen Guo; Hu, Qi Chun

    2014-01-01

    Biosynthesis of liquid fuels and biomass-based building block chemicals from microorganisms have been regarded as a competitive alternative route to traditional. Zymomonas mobilis possesses a number of desirable characteristics for its special Entner-Doudoroff pathway, which makes it an ideal platform for both metabolic engineering and commercial-scale production of desirable bio-products as the same as Escherichia coli and Saccharomyces cerevisiae based on consideration of future biomass biorefinery. Z. mobilis has been studied extensively on both fundamental and applied level, which will provide a basis for industrial biotechnology in the future. Furthermore, metabolic engineering of Z. mobilis for enhancing bio-ethanol production from biomass resources has been significantly promoted by different methods (i.e. mutagenesis, adaptive laboratory evolution, specific gene knock-out, and metabolic engineering). In addition, the feasibility of representative metabolites, i.e. sorbitol, bionic acid, levan, succinic acid, isobutanol, and isobutanol produced by Z. mobilis and the strategies for strain improvements are also discussed or highlighted in this paper. Moreover, this review will present some guidelines for future developments in the bio-based chemical production using Z. mobilis as a novel industrial platform for future biofineries.

  14. PROSPECTIVE EVALUATION FOR THE SUGAR CANE FACTORY TRANSFORMATION IN BIOREFINERY

    Directory of Open Access Journals (Sweden)

    Rocío Rodríguez Plaza

    2015-10-01

    Full Text Available The present work has as goal to evaluate prospectively alternative of transformation in the "5 de Septiembre" sugar industry, located in Cienfuegos, for a superfine alcohol biorefinery. Two alternatives were taking into account; the first one was the installation of a distillery for a capacity of 500 hl/d of superfine alcohol, using the molasses and 10% of the filters juice coming from the sugar mill, as complement of the stage of fermentation, and also a plant of biodiesel production starting from microalgae biomass and of mud separated in the sugar mill and another installation of a distillery for a similar capacity of 500 Hl/d of superfine ethanol using molasses, the filters juices and microalgae hydrolysate. For the second alternative, it intends a distillery where saving of 67 % for the molasses, and 22.73 % for the water, these results are experimentally obtained. The most feasible alternative obtain 5 years of payback period, 21 % of an IRR and U$D 37104 419.21 of NPV.

  15. Dilute alkali pretreatment of softwood pine: A biorefinery approach.

    Science.gov (United States)

    Safari, Ali; Karimi, Keikhosro; Shafiei, Marzieh

    2017-06-01

    Dilute alkali pretreatment was performed on softwood pine to maximize ethanol and biogas production via a biorefinery approach. Alkali pretreatments were performed with 0-2% w/v NaOH at 100-180°C for 1-5h. The liquid fraction of the pretreated substrates was subjected to anaerobic digestion. The solid fraction of the pretreatment was used for separate enzymatic hydrolysis and fermentation. High ethanol yields of 76.9‒78.0% were achieved by pretreatment with 2% (w/v) NaOH at 180°C. The highest biogas yield of 244mL/g volatile solid (at 25°C, 1bar) was achieved by the pretreatment with 1% (w/v) NaOH at 180°C. The highest gasoline equivalent (sum of ethanol and methane) of 197L per ton of pinewood and the lowest ethanol manufacturing cost of 0.75€/L was obtained after pretreatment with 1% NaOH at 180°C for 5h. The manufacturing cost of ethanol from untreated wood was 4.12€/L. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. A biorefinery concept using the green macroalgae Chaetomorpha linum for the coproduction of bioethanol and biogas

    International Nuclear Information System (INIS)

    Ben Yahmed, Nesrine; Jmel, Mohamed Amine; Ben Alaya, Monia; Bouallagui, Hassib; Marzouki, M. Nejib; Smaali, Issam

    2016-01-01

    Highlights: • Chaetomorpha linum was used as sustainable feedstock for co-production of bioethanol and biomethane. • An eco-friendly process was developed, only generating 0.3 ± 0.01 g/g of waste. • Ethanol yield obtained was 0.41 g/g reducing sugar. • Methane yield obtained was 0.26 ± 0.045 L/gVS. - Abstract: An innovative integrated biorefinery approach using the green macroalgae Chaetomorpha linum was investigated in the present study for the co-production of bioethanol and biogas. Among three pretreatments of C. linum biomass, consisting of acidic, neutral and alkali ones, 3% NaOH pretreatment gave the best result in terms of thallus disintegration, biomass recovery and enzymatic digestibility as demonstrated by scanning electron microscopy and saccharification tests. The hydrolysis of C. linum feedstock with a crude specific enzyme preparation, locally produced from fermentation of Aspergillus awamori, at 45 °C, pH 5 for 30 h gave the maximum yield of fermentable sugar of 0.22 ± 0.02 g/g dry substrate. An ethanol yield of 0.41 g/g reducing sugar corresponding to about 0.093 g/g pretreated algae was obtained after alcoholic fermentation by Saccharomyces cerevisiae. In the integrated proposed process, mycelium issued from the fungal fermentation, liquid issued from alkali pretreatment, residual from the non-hydrolysable biomass and all effluents and co-products represent a heterogeneous substrate that feed an anaerobic digester for biogas production. GC-analysis of this later showed that the biomethane yield reached 0.26 ± 0.045 L/gVS. This study presents therefore an eco-friendly biorefining process, which efficiently coproduce bioethanol and biomethane and generate only a single waste (0.3 ± 0.01 g/g) allowing an almost complete conversion of the algal biomass.

  17. Residual biomass potential in olive tree cultivation and olive oil industry in Spain: valorization proposal in a biorefinery context

    Directory of Open Access Journals (Sweden)

    Paloma Manzanares

    2017-12-01

    Full Text Available Olive crop and olive oil industry generates several residues, i.e., olive tree pruning biomass (OTPB, extracted olive pomace (EOP and olive leaves (OL that could be used to produce high-added value products in an integrated biorefinery. OTPB is generated in the field as a result of pruning operation to remove old branches; EOP is the main residue of the pomace olive oil extracting industry after extraction with hexane of residual oil contained in olive pomace; and OL comes from the olive cleaning process carried out at olive mills, where small branches and leaves are separated by density. In this work, an analysis of the potential of OTPB, EOP and OL residues was addressed by estimating the production volumes at national level and the spatial distribution of these residues using geographic information system software. Information provided by public institutions and personal surveys to the industries was evaluated. Moreover, chemical analysis of the residues was undertaken and the results used to make a first assessment of valorization into biofuels such as bioethanol and bio based chemicals. Results show that close to 4.2 million tons/year of EOP, OL and OTPB derived from olive oil industry and olive tree cultivation in Spain could be available as a raw material for biorefineries in Spain. The analysis of the chemical characteristics indicates the relevant potential of these feedstocks for the production of bioethanol and other compounds such as phenols based on suitable processing and conversion routes, although techno-economic evaluations must be tackled to refine this approach.

  18. Residual biomass potential in olive tree cultivation and olive oil industry in Spain: valorization proposal in a biorefinery contex

    Energy Technology Data Exchange (ETDEWEB)

    Manzanares, P.; Ruiz, E.; Ballesteros, M.; Negro, M.J.; Gallego, F.J.; López-Linares, J.C.; Castro, E.

    2017-07-01

    Olive crop and olive oil industry generates several residues, i.e., olive tree pruning biomass (OTPB), extracted olive pomace (EOP) and olive leaves (OL) that could be used to produce high-added value products in an integrated biorefinery. OTPB is generated in the field as a result of pruning operation to remove old branches; EOP is the main residue of the pomace olive oil extracting industry after extraction with hexane of residual oil contained in olive pomace; and OL comes from the olive cleaning process carried out at olive mills, where small branches and leaves are separated by density. In this work, an analysis of the potential of OTPB, EOP and OL residues was addressed by estimating the production volumes at national level and the spatial distribution of these residues using geographic information system software. Information provided by public institutions and personal surveys to the industries was evaluated. Moreover, chemical analysis of the residues was undertaken and the results used to make a first assessment of valorization into biofuels such as bioethanol and bio based chemicals. Results show that close to 4.2 million tons/year of EOP, OL and OTPB derived from olive oil industry and olive tree cultivation in Spain could be available as a raw material for biorefineries in Spain. The analysis of the chemical characteristics indicates the relevant potential of these feedstocks for the production of bioethanol and other compounds such as phenols based on suitable processing and conversion routes, although techno-economic evaluations must be tackled to refine this approach.

  19. Longitudinal Omics Modelling and Integration in Clinical Metabonomics Research: challenges in childhood metabolic health research

    Directory of Open Access Journals (Sweden)

    Peter eSperisen

    2015-08-01

    Full Text Available Systems biology is an important approach for deciphering the complex processes in health maintenance and the etiology of metabolic diseases. Such integrative methodologies will help better understand the molecular mechanisms involved in growth and development throughout childhood, and consequently will result in new insights about metabolic and nutritional requirements of infants, children and adults. To achieve this, a better understanding of the physiological processes at anthropometric, cellular and molecular level for any given individual is needed. In this respect, novel omics technologies in combination with sophisticated data modelling techniques are key. Due to the highly complex network of influential factors determining individual trajectories, it becomes imperative to develop proper tools and solutions that will comprehensively model biological information related to growth and maturation of our body functions. The aim of this review and perspective is to evaluate, succinctly, promising data analysis approaches to enable data integration for clinical research, with an emphasis on the longitudinal component. Approaches based on empirical and mechanistic modelling of omics data are essential to leverage findings from high dimensional omics datasets and enable biological interpretation and clinical translation. On the one hand, empirical methods, which provide quantitative descriptions of patterns in the data, are mostly used for exploring and mining datasets. On the other hand, mechanistic models are based on an understanding of the behavior of a system’s components and condense information about the known functions, allowing robust and reliable analyses to be performed by bioinformatics pipelines and similar tools. Herein, we will illustrate current examples, challenges and perspectives in the applications of empirical and mechanistic modelling in the context of childhood metabolic health research.

  20. Silicon integrated circuits advances in materials and device research

    CERN Document Server

    Kahng, Dawon

    1981-01-01

    Silicon Integrated Circuits, Part B covers the special considerations needed to achieve high-power Si-integrated circuits. The book presents articles about the most important operations needed for the high-power circuitry, namely impurity diffusion and oxidation; crystal defects under thermal equilibrium in silicon and the development of high-power device physics; and associated technology. The text also describes the ever-evolving processing technology and the most promising approaches, along with the understanding of processing-related areas of physics and chemistry. Physicists, chemists, an

  1. The simulation research for the dynamic performance of integrated PWR

    International Nuclear Information System (INIS)

    Yuan Jiandong; Xia Guoqing; Fu Mingyu

    2005-01-01

    The mathematical model of the reactor core of integrated PWR has been studied and simplified properly. With the lumped parameter method, authors have established the mathematical model of the reactor core, including the neutron dynamic equation, the feedback reactivities model and the thermo-hydraulic model of the reactor. Based on the above equations and models, the incremental transfer functions of the reactor core model have been built. By simulation experimentation, authors have compared the dynamic characteristics of the integrated PWR with the traditional dispersed PWR. The simulation results show that the mathematical models and equations are correct. (authors)

  2. General support for integrated assessment research. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Dowlatabadi, Hadi

    2001-03-01

    The climate change problem spans an extraordinarily large number of disciplines from earth sciences to social and political sciences. The interaction of processes described by these different fields is why climate change is such a complex issue. Keeping track of these interactions and bringing coherence to the assumptions underlying each disciplinary insight on the climate problem is a massive undertaking. Integrated assessment is an interdisciplinary approach designed to provide systematic evaluations of technically complex problems such as the analysis of environmental change challenges facing humanity. Ph.D. theses stemming from this application are summarized. Then some aspects of Integrated Climate Assessment Models are described.

  3. On a novel strategy for water recovery and recirculation in biorefineries through application of forward osmosis membranes

    DEFF Research Database (Denmark)

    Kalafatakis, Stavros; Braekevelt, Sylvie; Carlsen, Vilhelmsen

    2017-01-01

    A great amount of research has been performed during the last 10 years focusing on forward osmosis (FO)processes. The main driving force is to find an effective and low energy demanding methodology for water recovery as well as up-concentration of valuable products. Nevertheless, the energetic...... and financial benefits of this technology can be undermined from the fact that FO should be usually coupled with reverse osmosis (RO) for subsequent water purification and draw solution regeneration. Hence, a different approach was applied in order to omit the RO step. Crude glycerol and enzymatically...... pretreated wheat straw, which are common 2nd generation biorefinery feedstocks, have been evaluated as possible draw solution. In this way, water can be directly recovered and transferred back into the fermentation loop without further purification. Applying the Aquaporin InsideTM Forward Osmosis system...

  4. Improving the Integration of Young African Researchers into ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The freeze on recruitment in many research institutions and universities has resulted in an aging cohort of teaching and research personnel. Many young researchers work in the precarious situation of teaching assistants or temporary replacements, without the necessary scientific sponsorship to allow them to evolve in their ...

  5. Upgrading of lignocellulosic biorefinery to value-added chemicals: Sustainability and economics of bioethanol-derivatives

    DEFF Research Database (Denmark)

    Cheali, Peam; Posada, John A.; Gernaey, Krist

    2015-01-01

    with a sustainability assessment method is used as evaluation tool. First, an existing superstructure representing the lignocellulosic biorefinery design network is extended to include the options for catalytic conversion of bioethanol to value-added derivatives. Second, the optimization problem for process upgrade...... of operating profit for biorefineries producing bioethanol-derived chemicals (247 MM$/a and 241 MM$/a for diethyl ether and 1,3-butadiene, respectively). Second, the optimal designs for upgrading bioethanol (i.e. production of 1,3-butadiene and diethyl ether) performed also better with respect...... to sustainability compared with the petroleum-based processes. In both cases, the effects of the market price uncertainties were also analyzed by performing quantitative economic risk analysis and presented a significant risk of investment for a lignocellulosic biorefinery (12 MM$/a and 92 MM$/a for diethyl ether...

  6. Application of CAPEC Lipid Property Databases in the Synthesis and Design of Biorefinery Networks

    DEFF Research Database (Denmark)

    Bertran, Maria-Ona; Cunico, Larissa; Gani, Rafiqul

    Petroleum is currently the primary raw material for the production of fuels and chemicals. Consequently, our society is highly dependent on fossil non-renewable resources. However, renewable raw materials are recently receiving increasing interest for the production of chemicals and fuels, so a n...... of biorefinery networks. The objective of this work is to show the application of databases of physical and thermodynamic properties of lipid components to the synthesis and design of biorefinery networks.......]. The wide variety and complex nature of components in biorefineries poses a challenge with respect to the synthesis and design of these types of processes. Whereas physical and thermodynamic property data or models for petroleum-based processes are widely available, most data and models for biobased...

  7. Synthesis and Design of Biorefinery Processing Networks with Uncertainty and Sustainability analysis

    DEFF Research Database (Denmark)

    Cheali, Peam; Gernaey, Krist; Sin, Gürkan

    combinations of processing networks. The optimization of the network is formulated as a mixed integer nonlinear programming type of problem and solved in GAMS. The methodology was applied for designing optimal biorefinery networks considering biochemical routes. Furthermore, the methodology has also been...... for processing renewable feedstocks, with the aim of bridging the gap for fuel, chemical and material production. This project is focusing on biorefinery network design, in particular for early stage design and development studies. Optimal biorefinery design is a challenging problem. It is a multi......-objective decision-making problem not only with respect to technical and economic feasibility but also with respect to environmental impacts, sustainability constraints and limited availability & uncertainties of input data at the early design stage. It is therefore useful to develop a systematic methodology...

  8. Integrative research on environmental and landscape change: PhD students' motivations and challenges.

    Science.gov (United States)

    Tress, Bärbel; Tress, Gunther; Fry, Gary

    2009-07-01

    The growing demand for integrative (interdisciplinary or transdisciplinary) approaches in the field of environmental and landscape change has increased the number of PhD students working in this area. Yet, the motivations to join integrative projects and the challenges for PhD students have so far not been investigated. The aims of this paper were to identify the understanding of PhD students with regard to integrative research, their motivations to join integrative projects, their expectations in terms of integration and results, and to reveal the challenges they face in integrative projects. We collected data by a questionnaire survey of 104 PhD students attending five PhD Master Classes held from 2003 to 2006. We used manual content analysis to analyse the free-text answers. The results revealed that students lack a differentiated understanding of integrative approaches. The main motivations to join integrative projects were the dissertation subject, the practical relevance of the project, the intellectual stimulation of working with different disciplines, and the belief that integrative research is more innovative. Expectations in terms of integration were high. Core challenges for integration included intellectual and external challenges such as lack of knowledge of other disciplines, knowledge transfer, reaching depth, supervision, lack of exchange with other students and time demands. To improve the situation for PhD students, we suggest improving knowledge on integrative approaches, balancing practical applicability with theoretical advancement, providing formal introductions to other fields of research, and enhancing institutional support for integrative PhD projects.

  9. Integrating Biopsychosocial Intervention Research in a Changing Health Care Landscape

    Science.gov (United States)

    Ell, Kathleen; Oh, Hyunsung; Wu, Shinyi

    2016-01-01

    Objective: Safety net care systems are experiencing unprecedented change from the "Affordable Care Act," Patient-Centered Medical Home (PCMH) uptake, health information technology application, and growing of mental health care integration within primary care. This article provides a review of previous and current efforts in which social…

  10. Integration of Women into Management Positions: A Research Review.

    Science.gov (United States)

    Terborg, James R.

    This paper reviews the literature on the psychological and social processes involved in the integration of women into management positions. The author concentrates on two areas. First is the entry of women into management (including women's career choices, choice of organization, and the effects of these choices on the organization. These effects…

  11. Out of the fog: Catalyzing integrative capacity in interdisciplinary research.

    Science.gov (United States)

    Piso, Zachary; O'Rourke, Michael; Weathers, Kathleen C

    2016-04-01

    Social studies of interdisciplinary science investigate how scientific collaborations approach complex challenges that require multiple disciplinary perspectives. In order for collaborators to meet these complex challenges, interdisciplinary collaborations must develop and maintain integrative capacity, understood as the ability to anticipate and weigh tradeoffs in the employment of different disciplinary approaches. Here we provide an account of how one group of interdisciplinary fog scientists intentionally catalyzed integrative capacity. Through conversation, collaborators negotiated their commitments regarding the ontology of fog systems and the methodologies appropriate to studying fog systems, thereby enhancing capabilities which we take to constitute integrative capacity. On the ontological front, collaborators negotiated their commitments by setting boundaries to and within the system, layering different subsystems, focusing on key intersections of these subsystems, and agreeing on goals that would direct further investigation. On the methodological front, collaborators sequenced various methods, anchored methods at different scales, validated one method with another, standardized the outputs of related methods, and coordinated methods to fit a common model. By observing the process and form of collaborator conversations, this case study demonstrates that social studies of science can bring into critical focus how interdisciplinary collaborators work toward an integrated conceptualization of study systems. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Vertical Integration at Junior and Intermediate Levels. School Research Newsletter.

    Science.gov (United States)

    Marklund, Inger, Ed.; Hanse, Mona-Britt, Ed.

    1984-01-01

    In recent years, there has been a rapid growth of interest in Sweden in vertically integrated classes in compulsory schools, especially at junior high school and intermediate grade levels. This development is supported in various ways by the curriculum, partly because it puts more emphasis than previous curricula on the occurrence of teaching…

  13. Using Research to Design Integrated Education and Training Programs

    Science.gov (United States)

    Pappalardo, Michele; Schaffer, William R.

    2016-01-01

    With the passage of the Workforce Innovation and Opportunity Act (WIOA) of 2014, Northampton Community College began the creation of Integrated Education and Training (IE&T) programs in October 2015. After a needs assessment was conducted with the partners, programs were created to address the needs in the hospitality and healthcare sectors.…

  14. The Value of ERP Curriculum Integration: Perspectives from the Research

    Science.gov (United States)

    Hepner, Michelle; Dickson, Warren

    2013-01-01

    In the current economic conditions, many institutions face dwindling budgets and an increased focus on proving the value of the education provided. The effort and costs required to integrate Enterprise Resource Planning systems into course curricula are a significant investment of resources for any university. This paper examines the expense of…

  15. Leading Integrated Health and Social Care Systems: Perspectives from Research and Practice.

    Science.gov (United States)

    Evans, Jenna M; Daub, Stacey; Goldhar, Jodeme; Wojtak, Anne; Purbhoo, Dipti

    2016-01-01

    As the research evidence on integrated care has evolved over the past two decades, so too has the critical role leaders have for the implementation, effectiveness and sustainability of integrated care. This paper explores what it means to be an effective leader of integrated care initiatives by drawing from the experiences of a leadership team in implementing an award-winning integrated care program in Toronto, Canada. Lessons learned are described and assessed against existing theory and research to identify which skills and behaviours facilitate effective leadership of integrated care initiatives.

  16. Building a Foundation for Effective Technology Transfer through Integration with the Research Process : a Primer.

    Science.gov (United States)

    2016-03-01

    This primer aims to increase the effectiveness of T2 activity in transportation by describing how T2 practices can be successfully integrated into : the research process to capture the potential real-world benefits of our communitys research inves...

  17. Improving brain computer interface research through user involvement - The transformative potential of integrating civil society organisations in research projects

    Science.gov (United States)

    Wakunuma, Kutoma; Rainey, Stephen; Hansen, Christian

    2017-01-01

    Research on Brain Computer Interfaces (BCI) often aims to provide solutions for vulnerable populations, such as individuals with diseases, conditions or disabilities that keep them from using traditional interfaces. Such research thereby contributes to the public good. This contribution to the public good corresponds to a broader drive of research and funding policy that focuses on promoting beneficial societal impact. One way of achieving this is to engage with the public. In practical terms this can be done by integrating civil society organisations (CSOs) in research. The open question at the heart of this paper is whether and how such CSO integration can transform the research and contribute to the public good. To answer this question the paper describes five detailed qualitative case studies of research projects including CSOs. The paper finds that transformative impact of CSO integration is possible but by no means assured. It provides recommendations on how transformative impact can be promoted. PMID:28207882

  18. Improving brain computer interface research through user involvement - The transformative potential of integrating civil society organisations in research projects.

    Science.gov (United States)

    Stahl, Bernd Carsten; Wakunuma, Kutoma; Rainey, Stephen; Hansen, Christian

    2017-01-01

    Research on Brain Computer Interfaces (BCI) often aims to provide solutions for vulnerable populations, such as individuals with diseases, conditions or disabilities that keep them from using traditional interfaces. Such research thereby contributes to the public good. This contribution to the public good corresponds to a broader drive of research and funding policy that focuses on promoting beneficial societal impact. One way of achieving this is to engage with the public. In practical terms this can be done by integrating civil society organisations (CSOs) in research. The open question at the heart of this paper is whether and how such CSO integration can transform the research and contribute to the public good. To answer this question the paper describes five detailed qualitative case studies of research projects including CSOs. The paper finds that transformative impact of CSO integration is possible but by no means assured. It provides recommendations on how transformative impact can be promoted.

  19. A Belief-Space Approach to Integrated Intelligence - Research Area 10.3: Intelligent Networks

    Science.gov (United States)

    2017-12-05

    A Belief-Space Approach to Integrated Intelligence- Research Area 10.3: Intelligent Networks The views, opinions and/or findings contained in this...Technology (MIT) Title: A Belief-Space Approach to Integrated Intelligence- Research Area 10.3: Intelligent Networks Report Term: 0-Other Email: tlp...students presented progress and received feedback from the research group . o wrote papers on their research and submitted them to leading conferences

  20. Research network on capital markets and financial integration in Europe : results and experience after two years

    OpenAIRE

    European Central Bank ; Center for Financial Studies (CFS)

    2008-01-01

    In April 2002 the European Central Bank (ECB) and the Center for Financial Studies (CFS) launched the ECB-CFS Research Network to promote research on “Capital Markets and Financial Integration in Europe”. The ECB-CFS research network aims at stimulating top-level and policy-relevant research, significantly contributing to the understanding of the current and future structure and integration of the financial system in Europe and its international linkages with the United States and Japan. This...

  1. FACILITATING INTEGRATED SPATIO-TEMPORAL VISUALIZATION AND ANALYSIS OF HETEROGENEOUS ARCHAEOLOGICAL AND PALAEOENVIRONMENTAL RESEARCH DATA

    Directory of Open Access Journals (Sweden)

    C. Willmes

    2012-07-01

    Full Text Available In the context of the Collaborative Research Centre 806 "Our way to Europe" (CRC806, a research database is developed for integrating data from the disciplines of archaeology, the geosciences and the cultural sciences to facilitate integrated access to heterogeneous data sources. A practice-oriented data integration concept and its implementation is presented in this contribution. The data integration approach is based on the application of Semantic Web Technology and is applied to the domains of archaeological and palaeoenvironmental data. The aim is to provide integrated spatio-temporal access to an existing wealth of data to facilitate research on the integrated data basis. For the web portal of the CRC806 research database (CRC806-Database, a number of interfaces and applications have been evaluated, developed and implemented for exposing the data to interactive analysis and visualizations.

  2. Techno-economic risk analysis of glycerol biorefinery concepts against market price fluctuation

    DEFF Research Database (Denmark)

    Gargalo, Carina L.; Cheali, Peam; Gernaey, Krist

    . The high-value added bio-products boost profitability, the high-volume fuel helps meet national energy targets, and the power production cuts costs and dodges greenhouse-gas emissions [1] [2] [3]. The increasing amount of biodiesel production worldwide (e.g. from vegetable oils, palm oil, animal fats......) and the associated economic risks against historical market fluctuations when assessing the economics of competing glycerol biorefinery concepts. The aim is to compare the fitness/survival of the biorefinery concepts under extreme market disturbances. To perform this analysis, we used a superstructure based...

  3. Crop residues as raw materials for biorefinery systems - A LCA case study

    International Nuclear Information System (INIS)

    Cherubini, Francesco; Ulgiati, Sergio

    2010-01-01

    Our strong dependence on fossil fuels results from the intensive use and consumption of petroleum derivatives which, combined with diminishing oil resources, causes environmental and political concerns. The utilization of agricultural residues as raw materials in a biorefinery is a promising alternative to fossil resources for production of energy carriers and chemicals, thus mitigating climate change and enhancing energy security. This paper focuses on a biorefinery concept which produces bioethanol, bioenergy and biochemicals from two types of agricultural residues, corn stover and wheat straw. These biorefinery systems are investigated using a Life Cycle Assessment (LCA) approach, which takes into account all the input and output flows occurring along the production chain. This approach can be applied to almost all the other patterns that convert lignocellulosic residues into bioenergy and biochemicals. The analysis elaborates on land use change aspects, i.e. the effects of crop residue removal (like decrease in grain yields, change in soil N 2 O emissions and decrease of soil organic carbon). The biorefinery systems are compared with the respective fossil reference systems producing the same amount of products/services from fossils instead of biomass. Since climate change mitigation and energy security are the two most important driving forces for biorefinery development, the assessment focuses on greenhouse gas (GHG) emissions and cumulative primary energy demand, but other environmental categories are evaluated as well. Results show that the use of crop residues in a biorefinery saves GHG emissions and reduces fossil energy demand. For instance, GHG emissions are reduced by about 50% and more than 80% of non-renewable energy is saved. Land use change effects have a strong influence in the final GHG balance (about 50%), and their uncertainty is discussed in a sensitivity analysis. Concerning the investigation of the other impact categories, biorefinery systems

  4. BIOREFINE-2G — Result In Brief: Novel biopolymers from biorefinery waste-streams

    DEFF Research Database (Denmark)

    Stovicek, Vratislav; Chen, Xiao; Borodina, Irina

    Second generation biorefineries are all about creating value from waste, so it seems only right that the ideal plant should leave nothing behind. With this in mind, the BIOREFINE-2G project has developed novel processes to convert pentose-rich side-streams into biopolymers.......Second generation biorefineries are all about creating value from waste, so it seems only right that the ideal plant should leave nothing behind. With this in mind, the BIOREFINE-2G project has developed novel processes to convert pentose-rich side-streams into biopolymers....

  5. Optimal processing pathway selection for microalgae-based biorefinery under uncertainty

    DEFF Research Database (Denmark)

    Rizwan, Muhammad; Zaman, Muhammad; Lee, Jay H.

    2015-01-01

    We propose a systematic framework for the selection of optimal processing pathways for a microalgaebased biorefinery under techno-economic uncertainty. The proposed framework promotes robust decision making by taking into account the uncertainties that arise due to inconsistencies among...... and shortage in the available technical information. A stochastic mixed integer nonlinear programming (sMINLP) problem is formulated for determining the optimal biorefinery configurations based on a superstructure model where parameter uncertainties are modeled and included as sampled scenarios. The solution...... the accounting of uncertainty are compared with respect to different objectives. (C) 2015 Elsevier Ltd. All rights reserved....

  6. Integrative Research on Organic Matter Cycling Across Aquatic Gradients

    Energy Technology Data Exchange (ETDEWEB)

    Ward, Nicholas D.; Bianchi, Thomas S.; Medeiros, Patricia M.; Seidel, Michael; Keil, Richard G.; Robinson, Carol

    2017-07-04

    The goal of this research topic was to motivate innovative research that blurs traditional disciplinary and geographical boundaries. As the scientific community continues to gain momentum and knowledge about how the natural world functions, it is increasingly important that we recognize the interconnected nature of earth systems and embrace the complexities of ecosystem transitions. We are pleased to present this body of work, which embodies the spirit of research spanning across the terrestrial-aquatic continuum, from mountains to the sea.

  7. Solar Radiation Research Laboratory | Energy Systems Integration Facility |

    Science.gov (United States)

    Solar Radiation Research Laboratory (SRRL) has been collecting continuous measurements of basic solar continuous operation. More than 75 instruments contribute to the Baseline Measurement System by recording

  8. Cultivating Perspectival Acuity: The Value and Cost of Integrating Theory, Craft, Research, and Practice

    Directory of Open Access Journals (Sweden)

    Joe Manganelli

    2016-10-01

    Full Text Available This paper presents reflections on integrating theory, craft, research, and practice to improve the accuracy and resiliency of each. The reflections build toward a set of statements about the value and the cost of integrating theory, craft, research, and practice. Specifically, the authors offer the Privileged Work / Non-Privileged Work Framework and concept of cultivating Perspectival Acuity.

  9. The Integrated Multi-Level Bilingual Teaching of "Social Research Methods"

    Science.gov (United States)

    Zhu, Yanhan; Ye, Jian

    2012-01-01

    "Social Research Methods," as a methodology course, combines theories and practices closely. Based on the synergy theory, this paper tries to establish an integrated multi-level bilingual teaching mode. Starting from the transformation of teaching concepts, we should integrate interactions, experiences, and researches together and focus…

  10. INTEGRAL CRITERIA FOR EVALUATION OF SCIENTIFIC AND TECHNICAL RESEARCH

    Directory of Open Access Journals (Sweden)

    Stanislav Nazarevich

    2015-09-01

    Full Text Available In the paper, we develop approaches to the estimation of production enterprises based on the criteria of classification of products, goods and services to innovative products. Developed their qualitative scale for interpreting the results of the evaluation, blind spots, which were not included in the intervals, are compensated by the use of fuzzy sets. In the presented method uses integral criterion based on fuzzy accessory products specific form. The obtained numerical values of the integral criterion reflect the adequacy of the technical characteristics to determine the form of new products, as well as identifying the characteristics of the gap to peers and benchmarks. The technique is applicable to the assessment processes of innovation and competitiveness of new and current products, as well as in dealing with the definition of the innovative features of the new products.

  11. Producing software by integration: challenges and research directions (keynote)

    OpenAIRE

    Inverardi , Paola; Autili , Marco; Di Ruscio , Davide; Pelliccione , Patrizio; Tivoli , Massimo

    2013-01-01

    International audience; Software is increasingly produced according to a certain goal and by integrating existing software produced by third-parties, typically black-box, and often provided without a machine readable documentation. This implies that development processes of the next future have to explicitly deal with an inherent incompleteness of information about existing software, notably on its behaviour. Therefore, on one side a software producer will less and less know the precise behav...

  12. Coastal remote sensing – towards integrated coastal research and management

    CSIR Research Space (South Africa)

    Lück-Vogel, Melanie

    2012-10-01

    Full Text Available coastal resources and anthropogenic infrastructure for a safer future. What is the role of remote sensing? The coastal zone connects terrestrial biophysical systems with marine systems. Some marine ecosystems cannot function without intact inland... for the development of sound integrated management solutions. To date, however, remote sensing applications usually focus on areas landward from the highwater line (?terrestrial? remote sensing), while ?marine? remote sensing does not pay attention to the shallow...

  13. Integrative review of international nursing research in Mainland China.

    Science.gov (United States)

    Li, M; Wei, L; Liu, H; Tang, L

    2009-03-01

    Nursing research in Mainland China is divided into two parts: domestic nursing research, comprising all publications in Chinese; and international nursing research, comprising all publications in English. Domestic nursing research has been developing rapidly, demonstrated by the increase in new national or regional journals and publications. However, little is known about the extent of international research. To outline the development of international nursing research publications in Mainland China and to provide suggestions for future development. All of the papers were retrieved from PubMed. The key search phase was 'China or P.R.China NOT Hong Kong NOT Taiwan NOT Macao [AD]', with the limits of 'English', 'nursing journals' as well as the published date up to '2007/09/30'. PubMed recorded 57 English papers that were originally conducted in Mainland China during the search period from 1989 to 30 September 2007. Thirty-seven of the total 57 (65%) publications were contributed by Beijing, Shanghai and Hubei. Forty-four of the 57 publications were conducted with collaborators from Hong Kong, the USA, the UK and Canada. Thirteen publications were funded by international societies, while only three were funded by the Chinese government. The research topics mainly focused on clinical research, nursing education and nursing management. This study indicates that international nursing research has been growing slowly in Mainland China along with provincial variations. The suggestions to improve nursing research include the reform of nursing education, the enhancement of the collaboration with the international societies and the establishment of research priorities.

  14. Qualitative Audience Research: Toward an Integrative Approach to Reception.

    Science.gov (United States)

    Jensen, Klaus Bruhn

    1987-01-01

    Analyzes research about the mass communication audience and describes a theoretical and methodological framework for further empirical studies. Discusses the (1) explanatory value of qualitative research; (2) social and cultural implications of the reception process, with special reference to television; and (3) applications and social relevance…

  15. Integrating Interdisciplinary Research-Based Experiences in Biotechnology Laboratories

    Science.gov (United States)

    Iyer, Rupa S.; Wales, Melinda E.

    2012-01-01

    The increasingly interdisciplinary nature of today's scientific research is leading to the transformation of undergraduate education. In addressing these needs, the University of Houston's College of Technology has developed a new interdisciplinary research-based biotechnology laboratory curriculum. Using the pesticide degrading bacterium,…

  16. Panafrican Research Agenda on the Integration of ICTs in Education ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    of ICTs in education. Training and educational research institutions in 10 countries (Cameroon, Congo, Egypt, Kenya, Mali, Morocco, Mozambique, Uganda, Sénégal and South Africa) will participate and strengthen their research capacity at the same time. An Observatory will be put in place to organize the collection, ...

  17. An Integrative Conceptual Framework of Disability: New Directions for Research.

    Science.gov (United States)

    Tate, Denise G.; Pledger, Constance

    2003-01-01

    Examines various disability paradigms across time, assessing the relative contribution of the socioecological perspective in guiding research designed to improve the lives of people with disabilities. Recommends new research directions that include a focus on life span issues, biomedicine, biotechnology, the efficacy and effectiveness of current…

  18. An integrative approach of the marketing research and benchmarking

    Directory of Open Access Journals (Sweden)

    Moraru Gina-Maria

    2017-01-01

    Full Text Available The accuracy of the manager’s actions in a firm depends, among other things, on the accuracy of his/her information about all processes. At this issue, developing a marketing research is essential, because it provides information that represents the current situation in organization and on the market. Although specialists devote the marketing research exclusively to the organizational marketing function, practice has shown that it can be used in any other function of the company: production, finance, human resources, research and development. Firstly, the paper presents the opportunities to use the marketing research as a management tool in various stages of creative thinking. Secondly, based on a study made from secondary sources of economic literature, the paper draws a parallel between marketing research and benchmarking. Finally, the paper shows that creative benchmarking closes the management - marketing - creativity circle for the benefit of the organization and community.

  19. An integrative conceptual framework of disability. New directions for research.

    Science.gov (United States)

    Tate, Denise G; Pledger, Constance

    2003-04-01

    Advances in research on disability and rehabilitation are essential to creating equal opportunity, economic self-sufficiency, and full participation for persons with disabilities. Historically, such initiatives have focused on separate and specific areas, including neuroscience, molecular biology and genetics, gerontology, engineering and physical sciences, and social and behavioral sciences. Research on persons with disabilities should examine the broader context and trends of society that affect the total environment of persons with disabilities. This article examines the various disability paradigms across time, assessing the relative contribution of the socioecological perspective in guiding research designed to improve the lives of persons with disabilities. The authors recommend new research directions that include a focus on life span issues, biomedicine, biotechnology, the efficacy and effectiveness of current interventions, an emphasis on consumer-driven investigations within a socioecological perspective of disability, and the implications for research and practice.

  20. Techno-economical evaluation of protein extraction for microalgae biorefinery

    Science.gov (United States)

    Sari, Y. W.; Sanders, J. P. M.; Bruins, M. E.

    2016-01-01

    Due to scarcity of fossil feedstocks, there is an increasing demand for biobased fuels. Microalgae are considered as promising biobased feedstocks. However, microalgae based fuels are not yet produced at large scale at present. Applying biorefinery, not only for oil, but also for other components, such as carbohydrates and protein, may lead to the sustainable and economical microalgae-based fuels. This paper discusses two relatively mild conditions for microalgal protein extraction, based on alkali and enzymes. Green microalgae (Chlorella fusca) with and without prior lipid removal were used as feedstocks. Under mild conditions, more protein could be extracted using proteases, with the highest yields for microalgae meal (without lipids). The data on protein extraction yields were used to calculate the costs for producing 1 ton of microalgal protein. The processing cost for the alkaline method was € 2448 /ton protein. Enzymatic method performed better from an economic point of view with € 1367 /ton protein on processing costs. However, this is still far from industrially feasible. For both extraction methods, biomass cost per ton of produced product were high. A higher protein extraction yield can partially solve this problem, lowering processing cost to €620 and 1180 /ton protein product, using alkali and enzyme, respectively. Although alkaline method has lower processing cost, optimization appears to be better achievable using enzymes. If the enzymatic method can be optimized by lowering the amount of alkali added, leading to processing cost of € 633/ton protein product. Higher revenue can be generated when the residue after protein extraction can be sold as fuel, or better as a highly digestible feed for cattle.