WorldWideScience

Sample records for integrated biomedical solutions

  1. Integrated Biomaterials for Biomedical Technology

    CERN Document Server

    Ramalingam, Murugan; Ramakrishna, Seeram; Kobayashi, Hisatoshi

    2012-01-01

    This cutting edge book provides all the important aspects dealing with the basic science involved in materials in biomedical technology, especially structure and properties, techniques and technological innovations in material processing and characterizations, as well as the applications. The volume consists of 12 chapters written by acknowledged experts of the biomaterials field and covers a wide range of topics and applications.

  2. Integrating systems biology models and biomedical ontologies

    Directory of Open Access Journals (Sweden)

    de Bono Bernard

    2011-08-01

    Full Text Available Abstract Background Systems biology is an approach to biology that emphasizes the structure and dynamic behavior of biological systems and the interactions that occur within them. To succeed, systems biology crucially depends on the accessibility and integration of data across domains and levels of granularity. Biomedical ontologies were developed to facilitate such an integration of data and are often used to annotate biosimulation models in systems biology. Results We provide a framework to integrate representations of in silico systems biology with those of in vivo biology as described by biomedical ontologies and demonstrate this framework using the Systems Biology Markup Language. We developed the SBML Harvester software that automatically converts annotated SBML models into OWL and we apply our software to those biosimulation models that are contained in the BioModels Database. We utilize the resulting knowledge base for complex biological queries that can bridge levels of granularity, verify models based on the biological phenomenon they represent and provide a means to establish a basic qualitative layer on which to express the semantics of biosimulation models. Conclusions We establish an information flow between biomedical ontologies and biosimulation models and we demonstrate that the integration of annotated biosimulation models and biomedical ontologies enables the verification of models as well as expressive queries. Establishing a bi-directional information flow between systems biology and biomedical ontologies has the potential to enable large-scale analyses of biological systems that span levels of granularity from molecules to organisms.

  3. Integrating systems biology models and biomedical ontologies

    Science.gov (United States)

    2011-01-01

    Background Systems biology is an approach to biology that emphasizes the structure and dynamic behavior of biological systems and the interactions that occur within them. To succeed, systems biology crucially depends on the accessibility and integration of data across domains and levels of granularity. Biomedical ontologies were developed to facilitate such an integration of data and are often used to annotate biosimulation models in systems biology. Results We provide a framework to integrate representations of in silico systems biology with those of in vivo biology as described by biomedical ontologies and demonstrate this framework using the Systems Biology Markup Language. We developed the SBML Harvester software that automatically converts annotated SBML models into OWL and we apply our software to those biosimulation models that are contained in the BioModels Database. We utilize the resulting knowledge base for complex biological queries that can bridge levels of granularity, verify models based on the biological phenomenon they represent and provide a means to establish a basic qualitative layer on which to express the semantics of biosimulation models. Conclusions We establish an information flow between biomedical ontologies and biosimulation models and we demonstrate that the integration of annotated biosimulation models and biomedical ontologies enables the verification of models as well as expressive queries. Establishing a bi-directional information flow between systems biology and biomedical ontologies has the potential to enable large-scale analyses of biological systems that span levels of granularity from molecules to organisms. PMID:21835028

  4. Polydopamine Integrated Nanomaterials and Their Biomedical Applications.

    Science.gov (United States)

    Chen, Xiaoping; Huang, Yongshun; Yang, Gang; Li, Jiaxing; Wang, Tingting; Schulz, Olaf H; Jennings, Lisa K

    2015-01-01

    In the past few decades, the applications of nanomaterials in biologic systems have become one of the most studied areas. Many novel syntheses and processing methods have been developed to generate nanomaterials to enhance biomedical applications. Among those methods, polydopamine (PDA) integrated nanomaterials have attracted considerable interest for various types of biomedical applications. This concise review outlines the basic chemistry and material science regarding PDA and discusses its successful applications in drug delivery, biosensing, antifouling and antimicrobial activities, as well as its interaction with cells.

  5. Integrating image data into biomedical text categorization.

    Science.gov (United States)

    Shatkay, Hagit; Chen, Nawei; Blostein, Dorothea

    2006-07-15

    Categorization of biomedical articles is a central task for supporting various curation efforts. It can also form the basis for effective biomedical text mining. Automatic text classification in the biomedical domain is thus an active research area. Contests organized by the KDD Cup (2002) and the TREC Genomics track (since 2003) defined several annotation tasks that involved document classification, and provided training and test data sets. So far, these efforts focused on analyzing only the text content of documents. However, as was noted in the KDD'02 text mining contest-where figure-captions proved to be an invaluable feature for identifying documents of interest-images often provide curators with critical information. We examine the possibility of using information derived directly from image data, and of integrating it with text-based classification, for biomedical document categorization. We present a method for obtaining features from images and for using them-both alone and in combination with text-to perform the triage task introduced in the TREC Genomics track 2004. The task was to determine which documents are relevant to a given annotation task performed by the Mouse Genome Database curators. We show preliminary results, demonstrating that the method has a strong potential to enhance and complement traditional text-based categorization methods.

  6. KaBOB: ontology-based semantic integration of biomedical databases.

    Science.gov (United States)

    Livingston, Kevin M; Bada, Michael; Baumgartner, William A; Hunter, Lawrence E

    2015-04-23

    The ability to query many independent biological databases using a common ontology-based semantic model would facilitate deeper integration and more effective utilization of these diverse and rapidly growing resources. Despite ongoing work moving toward shared data formats and linked identifiers, significant problems persist in semantic data integration in order to establish shared identity and shared meaning across heterogeneous biomedical data sources. We present five processes for semantic data integration that, when applied collectively, solve seven key problems. These processes include making explicit the differences between biomedical concepts and database records, aggregating sets of identifiers denoting the same biomedical concepts across data sources, and using declaratively represented forward-chaining rules to take information that is variably represented in source databases and integrating it into a consistent biomedical representation. We demonstrate these processes and solutions by presenting KaBOB (the Knowledge Base Of Biomedicine), a knowledge base of semantically integrated data from 18 prominent biomedical databases using common representations grounded in Open Biomedical Ontologies. An instance of KaBOB with data about humans and seven major model organisms can be built using on the order of 500 million RDF triples. All source code for building KaBOB is available under an open-source license. KaBOB is an integrated knowledge base of biomedical data representationally based in prominent, actively maintained Open Biomedical Ontologies, thus enabling queries of the underlying data in terms of biomedical concepts (e.g., genes and gene products, interactions and processes) rather than features of source-specific data schemas or file formats. KaBOB resolves many of the issues that routinely plague biomedical researchers intending to work with data from multiple data sources and provides a platform for ongoing data integration and development and for

  7. Electrical circuits in biomedical engineering problems with solutions

    CERN Document Server

    Keskin, Ali Ümit

    2017-01-01

    This authored monograph presents a comprehensive and in-depth analysis of electrical circuit theory in biomedical engineering, ideally suited as textbook for a course program. The book contains methods and theory, but the topical focus is placed on practical applications of circuit theory, including problems, solutions and case studies. The target audience primarily comprises researchers and experts in electrical engineering who intend to embark on biomedical applications. The book is also very well suited for graduate students in the field. .

  8. Integrated Care Model Developed by the Rwanda Biomedical ...

    African Journals Online (AJOL)

    Integrated Care Model Developed by the Rwanda Biomedical Center for Decentralization of ... Global and national burden of mental disorders has been increasingly ... was reactive, centralized, and overwhelmed by the need for their services.

  9. The Washington Academy of Biomedical Engineering (WABME) Quarterly Workshops: Clinical Problems and Engineering Solutions

    Science.gov (United States)

    2005-01-01

    The Washington Academy of Biomedical Engineering (WABME) is an interdisciplinary and multi-institutional effort to promote research, technology...transfer, and education in biomedical engineering in the national capital region. The core members of WABME are faculty from the biomedical engineering /bioengineering...solution-rich engineering and scientific disciplines. These workshops build connections within the local biomedical engineering community and enable

  10. Enclosing Solutions of Integral Equations

    DEFF Research Database (Denmark)

    Madsen, Kaj; NA NA NA Caprani, Ole; Stauning, Ole

    1996-01-01

    We present a method for enclosing the solution of an integral equation. It is assumed that a solution exists and that the corresponding integral operator T is a contraction near y. When solving the integral equation by iteration we obtain a result which is normally different from y because...

  11. Enclosing Solutions of Integral Equations

    DEFF Research Database (Denmark)

    Madsen, Kaj; NA NA NA Caprani, Ole; Stauning, Ole

    1996-01-01

    We present a method for enclosing the solution of an integral equation. It is assumed that a solution exists and that the corresponding integral operator T is a contraction near y. When solving the integral equation by iteration we obtain a result which is normally different from y because...

  12. Integration and Querying of Genomic and Proteomic Semantic Annotations for Biomedical Knowledge Extraction.

    Science.gov (United States)

    Masseroli, Marco; Canakoglu, Arif; Ceri, Stefano

    2016-01-01

    Understanding complex biological phenomena involves answering complex biomedical questions on multiple biomolecular information simultaneously, which are expressed through multiple genomic and proteomic semantic annotations scattered in many distributed and heterogeneous data sources; such heterogeneity and dispersion hamper the biologists' ability of asking global queries and performing global evaluations. To overcome this problem, we developed a software architecture to create and maintain a Genomic and Proteomic Knowledge Base (GPKB), which integrates several of the most relevant sources of such dispersed information (including Entrez Gene, UniProt, IntAct, Expasy Enzyme, GO, GOA, BioCyc, KEGG, Reactome, and OMIM). Our solution is general, as it uses a flexible, modular, and multilevel global data schema based on abstraction and generalization of integrated data features, and a set of automatic procedures for easing data integration and maintenance, also when the integrated data sources evolve in data content, structure, and number. These procedures also assure consistency, quality, and provenance tracking of all integrated data, and perform the semantic closure of the hierarchical relationships of the integrated biomedical ontologies. At http://www.bioinformatics.deib.polimi.it/GPKB/, a Web interface allows graphical easy composition of queries, although complex, on the knowledge base, supporting also semantic query expansion and comprehensive explorative search of the integrated data to better sustain biomedical knowledge extraction.

  13. The Theory of Biomedical Knowledge Integration(Ⅳ)

    Institute of Scientific and Technical Information of China (English)

    BAO Han-fei

    2005-01-01

    This paper presented some philosophic viewpoints of the Theory of BMKI (The Theory of Biomedical Knowledge Integration), a new exploration in BioMedical Informatics. It discussed an evolutional relation from propositional calculus, predicate calculus, through framework, to neural network.. The differences in exclusivity and other natures were explored for physical systems (the real world), quasi-physical systems (the copies of the real world) and mental systems(the abstracts of the real world). Based on their behaviours in cognitive sciences and knowledge engineering, the new concepts quasi-infinity or -infinitesimal,potential knowledge,dynamic knowledge were introduced. This paper has also described so called "big-or" space which is the base of scientific understanding or association. Furthermore the paper put forward the viewpoint that "reasoning only can implement in an axiomatic space" and then outlined the building processes of such kind of space. At last so called "beacon-andcompass strategy" in BMKI was introduced.

  14. Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics.

    Science.gov (United States)

    Ahmadraji, Termeh; Gonzalez-Macia, Laura; Ritvonen, Tapio; Willert, Andreas; Ylimaula, Satu; Donaghy, David; Tuurala, Saara; Suhonen, Mika; Smart, Dave; Morrin, Aoife; Efremov, Vitaly; Baumann, Reinhard R; Raja, Munira; Kemppainen, Antti; Killard, Anthony J

    2017-07-18

    Organic and printed electronics integration has the potential to revolutionize many technologies, including biomedical diagnostics. This work demonstrates the successful integration of multiple printed electronic functionalities into a single device capable of the measurement of hydrogen peroxide and total cholesterol. The single-use device employed printed electrochemical sensors for hydrogen peroxide electroreduction integrated with printed electrochromic display and battery. The system was driven by a conventional electronic circuit designed to illustrate the complete integration of silicon integrated circuits via pick and place or using organic electronic circuits. The device was capable of measuring 8 μL samples of both hydrogen peroxide (0-5 mM, 2.72 × 10(-6) A·mM(-1)) and total cholesterol in serum from 0 to 9 mM (1.34 × 10(-8) A·mM(-1), r(2) = 0.99, RSD < 10%, n = 3), and the result was output on a semiquantitative linear bar display. The device could operate for 10 min via a printed battery, and display the result for many hours or days. A mobile phone "app" was also capable of reading the test result and transmitting this to a remote health care provider. Such a technology could allow improved management of conditions such as hypercholesterolemia.

  15. Hybrid Solution for Integrated Trading

    Directory of Open Access Journals (Sweden)

    Vlad DIACONITA

    2010-01-01

    Full Text Available Integrated applications are complex solutions, whose complexity are determined by the economic processes they implement, the amount of data employed (millions of records grouped in hundreds of tables, databases, hundreds of GB and the number of users. Service oriented architecture (SOA, is now the most talked-about integration solution in mainstream journals, addressing both simple applications, for a department but also at enterprise level. SOA can refer to software architecture or to a way of standardizing the technical architecture of an enterprise and it shows its value when operating in several distinct and heterogeneous environments.

  16. Integrated Filters for Short Range Wireless and Biomedical Applications

    CERN Document Server

    Laoudias, Costas

    2012-01-01

    This book describes the design of low-voltage analog integrated filters using current mirrors, one of the most common building blocks both in analog and mixed-signal VLSI circuits, offering the advantages of low-voltage operation, derivation of resistorless topologies and electronic adjustment capability of their frequency characteristics.  Several design examples are described, using current mirrors that fulfill the requirements of modern low-power wireless and biomedical applications, such as universal biquadratic filter topologies, complex filters for Bluetooth/ZigBee low-IF receivers and Wavelet filters for cardiac signal detection. The experimental results from the fabricated chips will also be presented, showing their utility in modern low-voltage low-power portable devices.

  17. Integrating behavioral and biomedical research in HIV interventions: challenges and opportunities.

    Science.gov (United States)

    Rausch, Dianne M; Grossman, Cynthia I; Erbelding, Emily J

    2013-06-01

    Recent clinical trials have demonstrated overwhelming success of biomedical tools to prevent the spread of HIV infection. However, the complex and somewhat disparate results of some of these trials have highlighted the need for effective integration of biomedical and behavioral sciences in the design and implementation of any future intervention trial. Integrating behavioral and biomedical sciences will require appropriate behavioral theories that can be used in the context of biomedical clinical trials and multidisciplinary teams working together from the earliest stages of trial design through to completion. It is also clear that integration of behavioral science will be necessary to implement prevention at the population level and reverse the HIV epidemic.

  18. A Semantic Web management model for integrative biomedical informatics.

    Directory of Open Access Journals (Sweden)

    Helena F Deus

    Full Text Available BACKGROUND: Data, data everywhere. The diversity and magnitude of the data generated in the Life Sciences defies automated articulation among complementary efforts. The additional need in this field for managing property and access permissions compounds the difficulty very significantly. This is particularly the case when the integration involves multiple domains and disciplines, even more so when it includes clinical and high throughput molecular data. METHODOLOGY/PRINCIPAL FINDINGS: The emergence of Semantic Web technologies brings the promise of meaningful interoperation between data and analysis resources. In this report we identify a core model for biomedical Knowledge Engineering applications and demonstrate how this new technology can be used to weave a management model where multiple intertwined data structures can be hosted and managed by multiple authorities in a distributed management infrastructure. Specifically, the demonstration is performed by linking data sources associated with the Lung Cancer SPORE awarded to The University of Texas MD Anderson Cancer Center at Houston and the Southwestern Medical Center at Dallas. A software prototype, available with open source at www.s3db.org, was developed and its proposed design has been made publicly available as an open source instrument for shared, distributed data management. CONCLUSIONS/SIGNIFICANCE: The Semantic Web technologies have the potential to addresses the need for distributed and evolvable representations that are critical for systems Biology and translational biomedical research. As this technology is incorporated into application development we can expect that both general purpose productivity software and domain specific software installed on our personal computers will become increasingly integrated with the relevant remote resources. In this scenario, the acquisition of a new dataset should automatically trigger the delegation of its analysis.

  19. Combinatorial solutions to integrable hierarchies

    OpenAIRE

    Kazarian, M.; Lando, S.

    2015-01-01

    We give a review of modern approaches to constructing formal solutions to integrable hierarchies of mathematical physics, whose coefficients are answers to various enumerative problems. The relationship between these approaches and combinatorics of symmetric groups and their representations is explained. Applications of the results to constructing efficient computations in problems related to models of quantum field theories are given.

  20. Combinatorial solutions to integrable hierarchies

    Science.gov (United States)

    Kazarian, M. E.; Lando, S. K.

    2015-06-01

    This paper reviews modern approaches to the construction of formal solutions to integrable hierarchies of mathematical physics whose coefficients are answers to various enumerative problems. The relationship between these approaches and the combinatorics of symmetric groups and their representations is explained. Applications of the results to the construction of efficient computations in problems related to models of quantum field theories are described. Bibliography: 34 titles.

  1. Biomedical scientist training officers' evaluation of integrated (co-terminus) Applied Biomedical Science BSc programmes: a multicentre study.

    Science.gov (United States)

    Pitt, S J; Cunningham, J M

    2011-01-01

    The introduction of the Institute of Biomedical Science (IBMS) portfolio for pre-registration training in 2003 allowed universities to develop integrated (co-terminus) biomedical science BSc programmes. Students undertake structured placements within clinical pathology laboratories as part of their degree. The clinical training and professional development of students is undertaken by training officers (TOs), who are experienced Health Professions Council (HPC)-registered biomedical scientists and usually also members of the IBMS. This study aims to evaluate TOs' perceptions of these integrated degrees as a means of delivering pre-registration training for biomedical scientists. A questionnaire to collect quantitative data and be completed anonymously was sent to TOs, via staff at participating universities. Items considered TOs' perceptions in four categories: how well students fitted into the laboratory team, their professional and scientific development, the impact of delivering integrated degrees on service delivery, and the commitment to training students. Surveys took place in 2007, 2008 and 2009 and involved TOs taking students from 10, 14 and 17 universities each year, respectively. The response rates to the survey were 60% in 2007, 34% in 2008 and 12% in 2009. Participants were representative in terms of age, gender and pathology discipline and had a broad range of experience with students. The overall mean score for TOs perceptions was 3.38 in 2007 which increased significantly to 3.99 in 2009 (Kruskall Wallis test chi2 = 21.13, P<0.01). Mean scores in three of the four categories were positive in 2007, although the impact on service delivery was perceived negatively. In all areas, means were significantly greater in 2009. The results indicate that TOs view the integrated degrees favourably and are happy with the scientific and professional development of students. Although designing training sessions suitable for undergraduates took extra work initially

  2. Microfluidic devices with integrated biosensors for biomedical applications

    OpenAIRE

    2014-01-01

    [eng] In recent years, the LOC community has focused most of its research in the biomedical and biotechnology fields, due to the need of portable, low power consumption and low cost theranostics microdevices. Some developing countries do not have suitable medical diagnostics technologies and the supply and storage of the reagents is in many cases limited as well as the access to energy. Furthermore, developed countries are experimenting population aging needing novel low cost efficient diseas...

  3. Renewable energy integration challenges and solutions

    CERN Document Server

    Hossain, Jahangir

    2014-01-01

    This book examines challenges involved in the integration of renewable energy into existing electricity grids. It provides models of power systems to show how the integration will effect conventional grids and various solutions to minimize the impacts.

  4. Wafer-scale integrated micro-supercapacitors on an ultrathin and highly flexible biomedical platform.

    Science.gov (United States)

    Maeng, Jimin; Meng, Chuizhou; Irazoqui, Pedro P

    2015-02-01

    We present wafer-scale integrated micro-supercapacitors on an ultrathin and highly flexible parylene platform, as progress toward sustainably powering biomedical microsystems suitable for implantable and wearable applications. All-solid-state, low-profile (RF) rectifying circuit is achieved on a single parylene platform, yielding a complete RF energy harvesting microsystem. The system discharging rate is shown to improve by ~17 times in the presence of the integrated micro-supercapacitors. This result suggests that the integrated micro-supercapacitor technology described herein is a promising strategy for sustainably powering biomedical microsystems dedicated to implantable and wearable applications.

  5. Generation of open biomedical datasets through ontology-driven transformation and integration processes.

    Science.gov (United States)

    Carmen Legaz-García, María Del; Miñarro-Giménez, José Antonio; Menárguez-Tortosa, Marcos; Fernández-Breis, Jesualdo Tomás

    2016-06-03

    Biomedical research usually requires combining large volumes of data from multiple heterogeneous sources, which makes difficult the integrated exploitation of such data. The Semantic Web paradigm offers a natural technological space for data integration and exploitation by generating content readable by machines. Linked Open Data is a Semantic Web initiative that promotes the publication and sharing of data in machine readable semantic formats. We present an approach for the transformation and integration of heterogeneous biomedical data with the objective of generating open biomedical datasets in Semantic Web formats. The transformation of the data is based on the mappings between the entities of the data schema and the ontological infrastructure that provides the meaning to the content. Our approach permits different types of mappings and includes the possibility of defining complex transformation patterns. Once the mappings are defined, they can be automatically applied to datasets to generate logically consistent content and the mappings can be reused in further transformation processes. The results of our research are (1) a common transformation and integration process for heterogeneous biomedical data; (2) the application of Linked Open Data principles to generate interoperable, open, biomedical datasets; (3) a software tool, called SWIT, that implements the approach. In this paper we also describe how we have applied SWIT in different biomedical scenarios and some lessons learned. We have presented an approach that is able to generate open biomedical repositories in Semantic Web formats. SWIT is able to apply the Linked Open Data principles in the generation of the datasets, so allowing for linking their content to external repositories and creating linked open datasets. SWIT datasets may contain data from multiple sources and schemas, thus becoming integrated datasets.

  6. Integrated LTCC packaging for use in biomedical devices.

    Science.gov (United States)

    Chlebowski, Arthur L; Chow, Eric Y; Ellison, Casey; Irazoqui, Pedro P

    2012-01-01

    As implantable devices gain more widespread use, medical device manufacturers are constantly looking for novel materials that increase and improve capability and functionality. The packaging needs to be biocompatible, but it is also highly desirable for it to be radio transparent to facilitate wireless telemetry and remote powering. Low temperature co-fired ceramics (LTCC) provide a viable solution that meets these desired specifications while also having characteristics that support ease of manufacturing such as the ability for molding, shaping, and even embedding components within the material. In this work, inductor coils used for wireless telemetry and powering are integrated into the walls of the LTCC-based package to maximize the size of the passive component while optimizing the miniaturization of the implant. The package designed and fabricated in this work consisted of inductors approximating 20 mH with a quality factor of 7.8 at 2 MHz. When compared to similar devices in the literature the LTCC inductor out performed these devices when a power-link figure of merit is used for comparison.

  7. Asymptotically periodic solutions of Volterra integral equations

    Directory of Open Access Journals (Sweden)

    Muhammad N. Islam

    2016-03-01

    Full Text Available We study the existence of asymptotically periodic solutions of a nonlinear Volterra integral equation. In the process, we obtain the existence of periodic solutions of an associated nonlinear integral equation with infinite delay. Schauder's fixed point theorem is used in the analysis.

  8. Combination HIV prevention interventions: the potential of integrated behavioral and biomedical approaches.

    Science.gov (United States)

    Brown, Jennifer L; Sales, Jessica M; DiClemente, Ralph J

    2014-12-01

    Combination HIV prevention interventions that integrate efficacious behavioral and biomedical strategies offer the potential to reduce new HIV infections. We overview the efficacy data for three biomedical HIV prevention approaches, namely microbicides, pre-exposure prophylaxis (PrEP), and HIV vaccination; review factors associated with differential acceptability and uptake of these methods; and suggest strategies to optimize the effectiveness and dissemination of combination HIV prevention approaches. A narrative review was conducted highlighting key efficacy data for microbicides, PrEP, and an HIV vaccination and summarizing acceptability data for each of the three biomedical HIV prevention approaches. Recommendations for the integration and dissemination of combined behavioral and biomedical HIV prevention approaches are provided. To date, microbicides and an HIV vaccination have demonstrated limited efficacy for the prevention of HIV. However, PrEP has demonstrated efficacy in reducing HIV incident infections. A diverse array of factors influences both hypothetical willingness and actual usage of each biomedical prevention method. Strategies to effectively integrate and evaluate combination HIV prevention interventions are urgently needed.

  9. The Theory of Bio-Medical Knowledge Integration(Ⅵ)

    Institute of Scientific and Technical Information of China (English)

    BAO Han-fei

    2006-01-01

    This paper introduced the following new concepts:the cognitive goal, the cognitive goal for the declarative data of the patient records (PRs), The basic attributes of PR's data at the sides of generation, construction and cognition, the generalized data creator (GDC), type Ⅰ to Ⅵ+ of GDC, the cognitive directions of data: forward direction and backward direction, the apparent cognitive orientation and inapparent cognitive orientation, the cognitive granularity difference principle between the natural intelligence and the artificial intelligence, the generalized variable(GVAR) and the generalized value(GVAL), the variable and value transitivity law(V-V transitivity law), the attribute-combination irreversibility between the concept abstracting and embodying, an open model of the launching engine of bio-medical cognition, etc

  10. Integrated Confocal and Scanning Probe Microscopy for Biomedical Research

    Directory of Open Access Journals (Sweden)

    B.J. Haupt

    2006-01-01

    Full Text Available Atomic force microscopy (AFM continues to be developed, not only in design, but also in application. The new focus of using AFM is changing from pure material to biomedical studies. More frequently, it is being used in combination with other optical imaging methods, such as confocal laser scanning microscopy (CLSM and fluorescent imaging, to provide a more comprehensive understanding of biological systems. To date, AFM has been used increasingly as a precise micromanipulator, probing and altering the mechanobiological characteristics of living cells and tissues, in order to examine specific, receptor-ligand interactions, material properties, and cell behavior. In this review, we discuss the development of this new hybrid AFM, current research, and potential applications in diagnosis and the detection of disease.

  11. Export channel pricing management for integrated solutions

    OpenAIRE

    Roine, Henna; Sainio, Liisa-Maija; Saarenketo, Sami

    2012-01-01

    This article studies systems integrators' export channel pricing management for integrated solutions. We find support from our empirical case study for the notion that a systems integrator's export channel pricing strategy is multidimensional and dependent on international pricing environment and partner characteristics and that export partnerships have unique implications on a systems integrator's pricing process. The results show that giving up pricing control in export channel context may ...

  12. Export channel pricing management for integrated solutions

    OpenAIRE

    Roine, Henna; Sainio, Liisa-Maija; Saarenketo, Sami

    2012-01-01

    This article studies systems integrators' export channel pricing management for integrated solutions. We find support from our empirical case study for the notion that a systems integrator's export channel pricing strategy is multidimensional and dependent on international pricing environment and partner characteristics and that export partnerships have unique implications on a systems integrator's pricing process. The results show that giving up pricing control in export channel context may ...

  13. Integrating Heterogeneous Biomedical Data for Cancer Research: the CARPEM infrastructure

    OpenAIRE

    2016-01-01

    Summary Cancer research involves numerous disciplines. The multiplicity of data sources and their heterogeneous nature render the integration and the exploration of the data more and more complex. Translational research platforms are a promising way to assist scientists in these tasks. In this article, we identify a set of scientific and technical principles needed to build a translational research platform compatible with ethical requirements, data protection and data-integration problems. W...

  14. Integration of heterogeneous biomedical sensors into an ISO/IEEE 11073 compliant application.

    Science.gov (United States)

    Fioravanti, A; Fico, G; Arredondo, M T; Salvi, D; Villalar, J L

    2010-01-01

    Current trends in healthcare technology include mobile-based applications. Relevant advances in the integration of vital signs monitoring devices with mobile platforms are widely reported nowadays. In this context, conceiving and designing an interoperable application is essential due to the growing necessity of integrating a huge and heterogeneous amount of biomedical data, coming from a wide range of devices and sensors. In this paper the key research issues associated with such integration are presented as well as a specific proposal to solve these problems. It is based on a middleware architecture for the integration of biomedical sensors with mobile devices, derived from the ISO/IEEE 11073 standards family. The application has been developed in the framework of an EU-funded R&D project called METABO.

  15. The fully integrated biomedical engineering programme at Eindhoven University of Technology.

    Science.gov (United States)

    Slaaf, D W; van Genderen, M H P

    2009-05-01

    The development of a fully integrated biomedical engineering programme (life sciences included from the start) is described. Details are provided about background, implementation, and didactic concept: design centred learning combined with courses. The curriculum has developed into a bachelor-master's programme with two different master's degrees: Master's Degree in Biomedical Engineering and Master's Degree in Medical Engineering. Recently, the programme has adopted semester programming, has included a major and minor in the bachelor's degree phase, and a true bachelor's degree final project. Details about the programme and data about where graduates find jobs are provided in this paper.

  16. Biomedical text mining for research rigor and integrity: tasks, challenges, directions.

    Science.gov (United States)

    Kilicoglu, Halil

    2017-06-13

    An estimated quarter of a trillion US dollars is invested in the biomedical research enterprise annually. There is growing alarm that a significant portion of this investment is wasted because of problems in reproducibility of research findings and in the rigor and integrity of research conduct and reporting. Recent years have seen a flurry of activities focusing on standardization and guideline development to enhance the reproducibility and rigor of biomedical research. Research activity is primarily communicated via textual artifacts, ranging from grant applications to journal publications. These artifacts can be both the source and the manifestation of practices leading to research waste. For example, an article may describe a poorly designed experiment, or the authors may reach conclusions not supported by the evidence presented. In this article, we pose the question of whether biomedical text mining techniques can assist the stakeholders in the biomedical research enterprise in doing their part toward enhancing research integrity and rigor. In particular, we identify four key areas in which text mining techniques can make a significant contribution: plagiarism/fraud detection, ensuring adherence to reporting guidelines, managing information overload and accurate citation/enhanced bibliometrics. We review the existing methods and tools for specific tasks, if they exist, or discuss relevant research that can provide guidance for future work. With the exponential increase in biomedical research output and the ability of text mining approaches to perform automatic tasks at large scale, we propose that such approaches can support tools that promote responsible research practices, providing significant benefits for the biomedical research enterprise. Published by Oxford University Press 2017. This work is written by a US Government employee and is in the public domain in the US.

  17. Biomedical Diagnostics Using Manmade Nanostructures Integrated With Biomolecules

    Science.gov (United States)

    Wu, Tsai-Chin

    There has been extensive research done on the bioengineering applications of nanoparticles. This thesis extended that work and focused on the application of semiconductor nanoparticles specifically as nano-scale detectors. By integrating two novel nanomaterial components, quantum dots and aptamers, nano-scale detectors may be fabricated. These nano-scale detectors make systematic studies on the molecular level possible and have other advantages described in the thesis. The analytes for such nanobiosensors include ions, cells, oligonucleotides, peptides or proteins. In this research, foodborne pathogens and potassium ions were chosen as the primary targets in the development of the nanosensors described in this thesis; due to their importance in the food industry and the biological sciences, respectively. More specifically, quantum dots were conjugated with short single-stranded nucleic acids and their fluorescence response was studied and evaluated to determine the viability of using them in nanoscale detector applications. To optimize the nanosensors, nano-scale spacer molecules are introduced at selected locations near the active regions of the nanosensors, and nanosensors synthesized with two different aptamer sequences were performed. The nanosensors were then tested with different ions and in real biological fluids; the results indicated that these nanosensors have promising potential applications in both self-diagnostics devices and molecular biological science research. The electrophoresis behavior and Raman spectra of these conjugations were also studied to examine these conjugations, in efforts to achieve better control over the proportional compositions of the entities that form these nanostructures. Several electrokinetic behavior dependencies on the nanoconjugations were observed and examined with double layer theory. This thesis investigated this novel nanobiosensor thoroughly from probe construction, performance evaluation, optical property

  18. An Integrated Playful Music Learning Solution

    DEFF Research Database (Denmark)

    Jensen, Karl Kristoffer; Frimodt-Møller, Søren

    2015-01-01

    This paper presents an integrated solution using IT technologies to help a (young) musician learn a piece of music, or learn how to play an instru- ment. The rehearsal process is organized in sequences, consisting of various ac- tivities to be 'passed'. Several games are investigated that help...... in learning espe- cially difficult parts, or in the learning of an instrument. The integrated solution, demonstrated on a tablet, proposed in this paper also includes tools that assist the musician in the rehearsal process. Feedback consists of computer tracking that supports self-assessment of rehearsal...

  19. An Approach to Integrating Health Disparities within Undergraduate Biomedical Engineering Education.

    Science.gov (United States)

    Vazquez, Maribel; Marte, Otto; Barba, Joseph; Hubbard, Karen

    2017-08-28

    Health disparities are preventable differences in the incidence, prevalence and burden of disease among communities targeted by gender, geographic location, ethnicity and/or socio-economic status. While biomedical research has identified partial origin(s) of divergent burden and impact of disease, the innovation needed to eradicate health disparities in the United States requires unique engagement from biomedical engineers. Increasing awareness of the prevalence and consequences of health disparities is particularly attractive to today's undergraduates, who have undauntedly challenged paradigms believed to foster inequality. Here, the Department of Biomedical Engineering at The City College of New York (CCNY) has leveraged its historical mission of access-and-excellence to integrate the study of health disparities into undergraduate BME curricula. This article describes our novel approach in a multiyear study that: (i) Integrated health disparities modules at all levels of the required undergraduate BME curriculum; (ii) Developed opportunities to include impacts of health disparities into undergraduate BME research projects and mentored High School summer STEM training; and (iii) Established health disparities-based challenges as BME capstone design and/or independent entrepreneurship projects. Results illustrate the rising awareness of health disparities among the youngest BMEs-to-be, as well as abundant undergraduate desire to integrate health disparities within BME education and training.

  20. Integration of Multi-Modal Biomedical Data to Predict Cancer Grade and Patient Survival.

    Science.gov (United States)

    Phan, John H; Hoffman, Ryan; Kothari, Sonal; Wu, Po-Yen; Wang, May D

    2016-02-01

    The Big Data era in Biomedical research has resulted in large-cohort data repositories such as The Cancer Genome Atlas (TCGA). These repositories routinely contain hundreds of matched patient samples for genomic, proteomic, imaging, and clinical data modalities, enabling holistic and multi-modal integrative analysis of human disease. Using TCGA renal and ovarian cancer data, we conducted a novel investigation of multi-modal data integration by combining histopathological image and RNA-seq data. We compared the performances of two integrative prediction methods: majority vote and stacked generalization. Results indicate that integration of multiple data modalities improves prediction of cancer grade and outcome. Specifically, stacked generalization, a method that integrates multiple data modalities to produce a single prediction result, outperforms both single-data-modality prediction and majority vote. Moreover, stacked generalization reveals the contribution of each data modality (and specific features within each data modality) to the final prediction result and may provide biological insights to explain prediction performance.

  1. An Integrated Dashboard and Balanced Scorecard Solution

    Directory of Open Access Journals (Sweden)

    Gianina MIHAI

    2014-11-01

    Full Text Available Access to information has always been a stringent necessity for any organization. This necessity has become more stringent in the actual economic context, as decisions must be taken in the shortest time. That is why since, the early sixties, the Decision Support Systems appeared. These have evolved together with the client-server technology, during the eighties, towards the today’s Executive Support Systems. Nowadays, these systems tend to be replaced by Dashboards and Balanced Scorecards (BSC, which fulfill the more and more sophisticated and growing information needs of the decision factors. In this article, we shall present an integrated solution for creating dashboards and scorecards using an enterprise portal. In the same time, we will analyze the advantages and disadvantages of a such integrated solution vs. independent solution.

  2. Informatics Solutions for Smart Metering Systems Integration

    Directory of Open Access Journals (Sweden)

    Simona-Vasilica OPREA

    2015-01-01

    Full Text Available In this paper different aspects regarding smart metering systems integration have been depicted. Smart metering systems, renewable energy sources integration and advanced tariff systems implementation require informatics solution that could automatically collect and process data, forecast the behavior of electricity consumers, analyze trends regarding electricity prices, optimize the consumption of consumers, provide friendly interfaces, etc. They are advanced technologies that represent solutions for insufficient conventional primary energy sources, gas emissions, dependency on energy sources located outside European Union and issues related to energy efficiency. This paper mainly describes several informatics solutions correlated with operational requirements for smart metering system and our proposal for simplified architecture of smart metering systems, with three distinct levels (base level, middle level and top level and load profile calculation methods.

  3. Periodic solutions of Volterra integral equations

    Directory of Open Access Journals (Sweden)

    M. N. Islam

    1988-01-01

    Full Text Available Consider the system of equationsx(t=f(t+∫−∞tk(t,sx(sds,           (1andx(t=f(t+∫−∞tk(t,sg(s,x(sds.       (2Existence of continuous periodic solutions of (1 is shown using the resolvent function of the kernel k. Some important properties of the resolvent function including its uniqueness are obtained in the process. In obtaining periodic solutions of (1 it is necessary that the resolvent of k is integrable in some sense. For a scalar convolution kernel k some explicit conditions are derived to determine whether or not the resolvent of k is integrable. Finally, the existence and uniqueness of continuous periodic solutions of (1 and (2 are btained using the contraction mapping principle as the basic tool.

  4. Survey of biomedical and environental data bases, models, and integrated computer systems at Argonne National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Murarka, I.P.; Bodeau, D.J.; Scott, J.M.; Huebner, R.H.

    1978-08-01

    This document contains an inventory (index) of information resources pertaining to biomedical and environmental projects at Argonne National Laboratory--the information resources include a data base, model, or integrated computer system. Entries are categorized as models, numeric data bases, bibliographic data bases, or integrated hardware/software systems. Descriptions of the Information Coordination Focal Point (ICFP) program, the system for compiling this inventory, and the plans for continuing and expanding it are given, and suggestions for utilizing the services of the ICFP are outlined.

  5. Vlasov moments, integrable systems and singular solutions

    Energy Technology Data Exchange (ETDEWEB)

    Gibbons, John [Department of Mathematics, Imperial College London, London SW7 2AZ (United Kingdom); Holm, Darryl D. [Department of Mathematics, Imperial College London, London SW7 2AZ (United Kingdom); Computer and Computational Science Division, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)], E-mail: d.holm@ic.ac.uk; Tronci, Cesare [Department of Mathematics, Imperial College London, London SW7 2AZ (United Kingdom); TERA Foundation for Oncological Hadrontherapy, 11 V. Puccini, Novara 28100 (Italy)

    2008-02-11

    The Vlasov equation governs the evolution of the single-particle probability distribution function (PDF) for a system of particles interacting without dissipation. Its singular solutions correspond to the individual particle motions. The operation of taking the moments of the Vlasov equation is a Poisson map. The resulting Lie-Poisson Hamiltonian dynamics of the Vlasov moments is found to be integrable is several cases. For example, the dynamics for coasting beams in particle accelerators is associated by a hodograph transformation to the known integrable Benney shallow-water equation. After setting the context, the Letter focuses on geodesic Vlasov moment equations. Continuum closures of these equations at two different orders are found to be integrable systems whose singular solutions characterize the geodesic motion of the individual particles.

  6. Integrating Variable Renewable Energy: Challenges and Solutions

    Energy Technology Data Exchange (ETDEWEB)

    Bird, L.; Milligan, M.; Lew, D.

    2013-09-01

    In the U.S., a number of utilities are adopting higher penetrations of renewables, driven in part by state policies. While power systems have been designed to handle the variable nature of loads, the additional supply-side variability and uncertainty can pose new challenges for utilities and system operators. However, a variety of operational and technical solutions exist to help integrate higher penetrations of wind and solar generation. This paper explores renewable energy integration challenges and mitigation strategies that have been implemented in the U.S. and internationally, including forecasting, demand response, flexible generation, larger balancing areas or balancing area cooperation, and operational practices such as fast scheduling and dispatch.

  7. Supply Chain Integration: Challenges and Solutions

    OpenAIRE

    Sweeney, Edward

    2011-01-01

    Rapid changes in technological development are forcing businesses to continuously innovate to improve their competitiveness, which is particularly evident in logistics and supply chain management (SCM), where innovation impacts both the strategic and operational levels. Supply Chain Innovation for Competing in Highly Dynamic Markets: Challenges and Solutions investigates the role of innovation in the management of supply chains of today. This book focuses on supply chain integration from both...

  8. Silicon-on-insulator-based complementary metal oxide semiconductor integrated optoelectronic platform for biomedical applications

    Science.gov (United States)

    Mujeeb-U-Rahman, Muhammad; Scherer, Axel

    2016-12-01

    Microscale optical devices enabled by wireless power harvesting and telemetry facilitate manipulation and testing of localized biological environments (e.g., neural recording and stimulation, targeted delivery to cancer cells). Design of integrated microsystems utilizing optical power harvesting and telemetry will enable complex in vivo applications like actuating a single nerve, without the difficult requirement of extreme optical focusing or use of nanoparticles. Silicon-on-insulator (SOI)-based platforms provide a very powerful architecture for such miniaturized platforms as these can be used to fabricate both optoelectronic and microelectronic devices on the same substrate. Near-infrared biomedical optics can be effectively utilized for optical power harvesting to generate optimal results compared with other methods (e.g., RF and acoustic) at submillimeter size scales intended for such designs. We present design and integration techniques of optical power harvesting structures with complementary metal oxide semiconductor platforms using SOI technologies along with monolithically integrated electronics. Such platforms can become the basis of optoelectronic biomedical systems including implants and lab-on-chip systems.

  9. Solution methods for very highly integrated circuits.

    Energy Technology Data Exchange (ETDEWEB)

    Nong, Ryan; Thornquist, Heidi K.; Chen, Yao; Mei, Ting; Santarelli, Keith R.; Tuminaro, Raymond Stephen

    2010-12-01

    While advances in manufacturing enable the fabrication of integrated circuits containing tens-to-hundreds of millions of devices, the time-sensitive modeling and simulation necessary to design these circuits poses a significant computational challenge. This is especially true for mixed-signal integrated circuits where detailed performance analyses are necessary for the individual analog/digital circuit components as well as the full system. When the integrated circuit has millions of devices, performing a full system simulation is practically infeasible using currently available Electrical Design Automation (EDA) tools. The principal reason for this is the time required for the nonlinear solver to compute the solutions of large linearized systems during the simulation of these circuits. The research presented in this report aims to address the computational difficulties introduced by these large linearized systems by using Model Order Reduction (MOR) to (i) generate specialized preconditioners that accelerate the computation of the linear system solution and (ii) reduce the overall dynamical system size. MOR techniques attempt to produce macromodels that capture the desired input-output behavior of larger dynamical systems and enable substantial speedups in simulation time. Several MOR techniques that have been developed under the LDRD on 'Solution Methods for Very Highly Integrated Circuits' will be presented in this report. Among those presented are techniques for linear time-invariant dynamical systems that either extend current approaches or improve the time-domain performance of the reduced model using novel error bounds and a new approach for linear time-varying dynamical systems that guarantees dimension reduction, which has not been proven before. Progress on preconditioning power grid systems using multi-grid techniques will be presented as well as a framework for delivering MOR techniques to the user community using Trilinos and the Xyce circuit

  10. Critically engaging: integrating the social and the biomedical in international microbicides research.

    Science.gov (United States)

    Montgomery, Catherine M; Pool, Robert

    2011-09-27

    Randomized controlled trials and critical social theory are known not to be happy bedfellows. Such trials are embedded in a positivist view of the world, seeking definitive answers to testable questions; critical social theory questions the methods by which we deem the world knowable and may consider experiments in the biomedical sciences as social artifacts. Yet both of these epistemologically and methodologically divergent fields offer potentially important advances in HIV research. In this paper, we describe collaboration between social and biomedical researchers on a large, publicly funded programme to develop vaginal microbicides for HIV prevention. In terms of critical engagement, having integrated and qualitative social science components in the protocol meant potentially nesting alternative epistemologies at the heart of the randomized controlled trial. The social science research highlighted the fallibility and fragility of trial data by demonstrating inconsistencies in key behavioural measurements. It also foregrounded the disjuncture between biomedical conceptions of microbicides and the meanings and uses of the study gel in the context of users' everyday lives. These findings were communicated to the clinical and epidemiological members of the team on an ongoing basis via a feedback loop, through which new issues of concern could also be debated and, in theory, data collection adjusted to the changing needs of the programme. Although critical findings were taken on board by the trialists, a hierarchy of evidence nonetheless remained that limited the utility of some social science findings. This was in spite of mutual respect between clinical epidemiologists and social scientists, equal representation in management and coordination bodies, and equity in funding for the different disciplines. We discuss the positive role that social science integrated into an HIV prevention trial can play, but nonetheless highlight tensions that remain where a hierarchy

  11. Critically engaging: integrating the social and the biomedical in international microbicides research

    Science.gov (United States)

    2011-01-01

    Randomized controlled trials and critical social theory are known not to be happy bedfellows. Such trials are embedded in a positivist view of the world, seeking definitive answers to testable questions; critical social theory questions the methods by which we deem the world knowable and may consider experiments in the biomedical sciences as social artifacts. Yet both of these epistemologically and methodologically divergent fields offer potentially important advances in HIV research. In this paper, we describe collaboration between social and biomedical researchers on a large, publicly funded programme to develop vaginal microbicides for HIV prevention. In terms of critical engagement, having integrated and qualitative social science components in the protocol meant potentially nesting alternative epistemologies at the heart of the randomized controlled trial. The social science research highlighted the fallibility and fragility of trial data by demonstrating inconsistencies in key behavioural measurements. It also foregrounded the disjuncture between biomedical conceptions of microbicides and the meanings and uses of the study gel in the context of users’ everyday lives. These findings were communicated to the clinical and epidemiological members of the team on an ongoing basis via a feedback loop, through which new issues of concern could also be debated and, in theory, data collection adjusted to the changing needs of the programme. Although critical findings were taken on board by the trialists, a hierarchy of evidence nonetheless remained that limited the utility of some social science findings. This was in spite of mutual respect between clinical epidemiologists and social scientists, equal representation in management and coordination bodies, and equity in funding for the different disciplines. We discuss the positive role that social science integrated into an HIV prevention trial can play, but nonetheless highlight tensions that remain where a hierarchy

  12. Integration of extracellular RNA profiling data using metadata, biomedical ontologies and Linked Data technologies

    Directory of Open Access Journals (Sweden)

    Sai Lakshmi Subramanian

    2015-08-01

    Full Text Available The large diversity and volume of extracellular RNA (exRNA data that will form the basis of the exRNA Atlas generated by the Extracellular RNA Communication Consortium pose a substantial data integration challenge. We here present the strategy that is being implemented by the exRNA Data Management and Resource Repository, which employs metadata, biomedical ontologies and Linked Data technologies, such as Resource Description Framework to integrate a diverse set of exRNA profiles into an exRNA Atlas and enable integrative exRNA analysis. We focus on the following three specific data integration tasks: (a selection of samples from a virtual biorepository for exRNA profiling and for inclusion in the exRNA Atlas; (b retrieval of a data slice from the exRNA Atlas for integrative analysis and (c interpretation of exRNA analysis results in the context of pathways and networks. As exRNA profiling gains wide adoption in the research community, we anticipate that the strategies discussed here will increasingly be required to enable data reuse and to facilitate integrative analysis of exRNA data.

  13. Integration of extracellular RNA profiling data using metadata, biomedical ontologies and Linked Data technologies.

    Science.gov (United States)

    Subramanian, Sai Lakshmi; Kitchen, Robert R; Alexander, Roger; Carter, Bob S; Cheung, Kei-Hoi; Laurent, Louise C; Pico, Alexander; Roberts, Lewis R; Roth, Matthew E; Rozowsky, Joel S; Su, Andrew I; Gerstein, Mark B; Milosavljevic, Aleksandar

    2015-01-01

    The large diversity and volume of extracellular RNA (exRNA) data that will form the basis of the exRNA Atlas generated by the Extracellular RNA Communication Consortium pose a substantial data integration challenge. We here present the strategy that is being implemented by the exRNA Data Management and Resource Repository, which employs metadata, biomedical ontologies and Linked Data technologies, such as Resource Description Framework to integrate a diverse set of exRNA profiles into an exRNA Atlas and enable integrative exRNA analysis. We focus on the following three specific data integration tasks: (a) selection of samples from a virtual biorepository for exRNA profiling and for inclusion in the exRNA Atlas; (b) retrieval of a data slice from the exRNA Atlas for integrative analysis and (c) interpretation of exRNA analysis results in the context of pathways and networks. As exRNA profiling gains wide adoption in the research community, we anticipate that the strategies discussed here will increasingly be required to enable data reuse and to facilitate integrative analysis of exRNA data.

  14. The Semanticscience Integrated Ontology (SIO) for biomedical research and knowledge discovery.

    Science.gov (United States)

    Dumontier, Michel; Baker, Christopher Jo; Baran, Joachim; Callahan, Alison; Chepelev, Leonid; Cruz-Toledo, José; Del Rio, Nicholas R; Duck, Geraint; Furlong, Laura I; Keath, Nichealla; Klassen, Dana; McCusker, James P; Queralt-Rosinach, Núria; Samwald, Matthias; Villanueva-Rosales, Natalia; Wilkinson, Mark D; Hoehndorf, Robert

    2014-03-06

    The Semanticscience Integrated Ontology (SIO) is an ontology to facilitate biomedical knowledge discovery. SIO features a simple upper level comprised of essential types and relations for the rich description of arbitrary (real, hypothesized, virtual, fictional) objects, processes and their attributes. SIO specifies simple design patterns to describe and associate qualities, capabilities, functions, quantities, and informational entities including textual, geometrical, and mathematical entities, and provides specific extensions in the domains of chemistry, biology, biochemistry, and bioinformatics. SIO provides an ontological foundation for the Bio2RDF linked data for the life sciences project and is used for semantic integration and discovery for SADI-based semantic web services. SIO is freely available to all users under a creative commons by attribution license. See website for further information: http://sio.semanticscience.org.

  15. Integral solutions of fractional evolution equations with nondense domain

    Directory of Open Access Journals (Sweden)

    Haibo Gu

    2017-06-01

    Full Text Available In this article, we study the existence of integral solutions for two classes of fractional order evolution equations with nondensely defined linear operators. First, we consider the nonhomogeneous fractional order evolution equation and obtain its integral solution by Laplace transform and probability density function. Subsequently, based on the form of integral solution for nonhomogeneous fractional order evolution equation, we investigate the existence of integral solution for nonlinear fractional order evolution equation by noncompact measure method.

  16. 75 FR 9455 - U.S. Biomedical Corp., (f/k/a United Textiles & Toys, Inc.), U.S. Environmental Solutions, Inc...

    Science.gov (United States)

    2010-03-02

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION U.S. Biomedical Corp., (f/k/a United Textiles & Toys, Inc.), U.S. Environmental Solutions, Inc. (n... accurate information concerning the securities of U.S. Biomedical Corp. (f/k/a United Textiles & Toys,...

  17. An integrated solution for remote data access

    Science.gov (United States)

    Sapunenko, Vladimir; D'Urso, Domenico; dell'Agnello, Luca; Vagnoni, Vincenzo; Duranti, Matteo

    2015-12-01

    Data management constitutes one of the major challenges that a geographically- distributed e-Infrastructure has to face, especially when remote data access is involved. We discuss an integrated solution which enables transparent and efficient access to on-line and near-line data through high latency networks. The solution is based on the joint use of the General Parallel File System (GPFS) and of the Tivoli Storage Manager (TSM). Both products, developed by IBM, are well known and extensively used in the HEP computing community. Owing to a new feature introduced in GPFS 3.5, so-called Active File Management (AFM), the definition of a single, geographically-distributed namespace, characterised by automated data flow management between different locations, becomes possible. As a practical example, we present the implementation of AFM-based remote data access between two data centres located in Bologna and Rome, demonstrating the validity of the solution for the use case of the AMS experiment, an astro-particle experiment supported by the INFN CNAF data centre with the large disk space requirements (more than 1.5 PB).

  18. Down syndrome screening information in midwifery practices in the Netherlands: Strategies to integrate biomedical information.

    Science.gov (United States)

    Rosman, Sophia

    2016-03-01

    The aim of this qualitative study was to analyse counselling with regard to prenatal screening in midwifery consultations in the Netherlands where a national prenatal screening programme has only existed since 2007, after years of social and political debates. The methodology is based on in situ observations of 25 counselling consultations in four midwifery practices in two main cities in the Netherlands. The results of this study show that, since midwives are obliged to offer information on Down syndrome screening to all pregnant women (2007), they have to deal with the communication of medical screening information using biostatistical concepts to explain risks, calculations, probabilities and chromosomal anomalies. In order to avoid the risk of medicalization of their consultation, midwives develop strategies that allow them to integrate this new biomedical discourse while maintaining their low medicalized approach of midwife-led care. One of their main strategies is to switch from 'alarming' biomedical messages to 'reassuring words' in order to manage the anxiety induced by the information and to keep the control over their low medicalized consultation. They also tend to distance themselves from the obligation to talk about screening. The way midwives handle these counselling consultations allows them to respect their obligation to propose information, and to remain faithful to their struggle to protect the natural process of pregnancy as well as their professional autonomy.

  19. Hot topics in biomedical ultrasound: ultrasound therapy and its integration with ultrasonic imaging

    Science.gov (United States)

    Everbach, E. Carr

    2005-09-01

    Since the development of biomedical ultrasound imaging from sonar after WWII, there has been a clear divide between ultrasonic imaging and ultrasound therapy. While imaging techniques are designed to cause as little change as possible in the tissues through which ultrasound propagates, ultrasound therapy typically relies upon heating or acoustic cavitation to produce a desirable therapeutic effect. Concerns over the increasingly high acoustic outputs of diagnostic ultrasound scanners prompted the adoption of the Mechanical Index (MI) and Thermal Index (TI) in the early 1990s. Therapeutic applications of ultrasound, meanwhile, have evolved from deep tissue heating in sports medicine to include targeted drug delivery, tumor and plaque ablation, cauterization via high intensity focused ultrasound (HIFU), and accelerated dissolution of blood clots. The integration of ultrasonic imaging and therapy in one device is just beginning, but the promise of improved patient outcomes is balanced by regulatory and practical impediments.

  20. Automatic solution for detection, identification and biomedical monitoring of a cow using remote sensing for optimised treatment of cattle

    Directory of Open Access Journals (Sweden)

    Yevgeny Beiderman

    2014-12-01

    Full Text Available In this paper we show how a novel photonic remote sensing system assembled on a robotic platform can extract vital biomedical parameters from cattle including their heart beating, breathing and chewing activity. The sensor is based upon a camera and a laser using selfinterference phenomena. The whole system intends to provide an automatic solution for detection, identification and biomedical monitoring of a cow. The detection algorithm is based upon image processing involving probability map construction. The identification algorithms involve well known image pattern recognition techniques. The sensor is used on top of an automated robotic platform in order to support animal decision making. Field tests and computer simulated results are presented.

  1. eClims: An Extensible and Dynamic Integration Framework for Biomedical Information Systems.

    Science.gov (United States)

    Savonnet, Marinette; Leclercq, Eric; Naubourg, Pierre

    2016-11-01

    Biomedical information systems (BIS) require consideration of three types of variability: data variability induced by new high throughput technologies, schema or model variability induced by large scale studies or new fields of research, and knowledge variability resulting from new discoveries. Beyond data heterogeneity, managing variabilities in the context of BIS requires extensible and dynamic integration process. In this paper, we focus on data and schema variabilities and we propose an integration framework based on ontologies, master data, and semantic annotations. The framework addresses issues related to: 1) collaborative work through a dynamic integration process; 2) variability among studies using an annotation mechanism; and 3) quality control over data and semantic annotations. Our approach relies on two levels of knowledge: BIS-related knowledge is modeled using an application ontology coupled with UML models that allow controlling data completeness and consistency, and domain knowledge is described by a domain ontology, which ensures data coherence. A system build with the eClims framework has been implemented and evaluated in the context of a proteomic platform.

  2. Biomedical photonics handbook biomedical diagnostics

    CERN Document Server

    Vo-Dinh, Tuan

    2014-01-01

    Shaped by Quantum Theory, Technology, and the Genomics RevolutionThe integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, studen

  3. [An integral chip for the multiphase pulse-duration modulation used for voltage changer in biomedical microprocessor systems].

    Science.gov (United States)

    Balashov, A M; Selishchev, S V

    2004-01-01

    An integral chip (IC) was designed for controlling the step-down pulse voltage converter, which is based on the multiphase pulse-duration modulation, for use in biomedical microprocessor systems. The CMOS technology was an optimal basis for the IC designing. An additional feedback circuit diminishes the output voltage dispersion at dynamically changing loads.

  4. A Domino Game Developed To Integrate Basic Disciplines Of Graduation Courses In The Biomedical Area

    Directory of Open Access Journals (Sweden)

    J. D. Gonçalves

    2009-05-01

    Full Text Available Undergraduate students of the biomedical area, such as Medicine, Odontology, Biomedicine,  show considerable difficulty in learni ng basic disciplines, which contributes to the high degree of failure shown in these disciplines. Among them, Biochemistry is “accused” of being the most difficult one and integration of its contents with other  disciplines is still not fully achieved, despite the new technological tools available nowadays. Considering this, some Odontology students produced a domino game to exercise biochemistry knowledge while integrating it with microbiology, but keeping the fun of the original game. In this version of the classic game the number on the pieces were changed to specific subjects in biochemistry or microbiology. Associating the pieces require not only the ordinary strategies of the classic game, but also the academic experience on the related areas. The  students involved in the  development of this game acknowledged it as a helpful tool to better understanding biochemistry as well as microbiology. The formal presentation of the game to the others students of our class brought up similar considerations. The production and distribution of this kind of games might help young students of their career beginnings.

  5. Using Interactive 3D PDF for Exploring Complex Biomedical Data: Experiences and Solutions.

    Science.gov (United States)

    Newe, Axel; Becker, Linda

    2016-01-01

    The Portable Document Format (PDF) is the most commonly used file format for the exchange of electronic documents. A lesser-known feature of PDF is the possibility to embed three-dimensional models and to display these models interactively with a qualified reader. This technology is well suited to present, to explore and to communicate complex biomedical data. This applies in particular for data which would suffer from a loss of information if it was reduced to a static two-dimensional projection. In this article, we present applications of 3D PDF for selected scholarly and clinical use cases in the biomedical domain. Furthermore, we present a sophisticated tool for the generation of respective PDF documents.

  6. Bounded solutions for fuzzy differential and integral equations

    Energy Technology Data Exchange (ETDEWEB)

    Nieto, Juan J. [Departamento de Analisis Matematico Facultad de Matematicas Universidad de Santiago de Compostela, 15782 (Spain)] e-mail: amnieto@usc.es; Rodriguez-Lopez, Rosana [Departamento de Analisis Matematico Facultad de Matematicas Universidad de Santiago de Compostela, 15782 (Spain)] e-mail: amrosana@usc.es

    2006-03-01

    We find sufficient conditions for the boundness of every solution of first-order fuzzy differential equations as well as certain fuzzy integral equations. Our results are based on several theorems concerning crisp differential and integral inequalities.

  7. Multicomponent integrable wave equations: II. Soliton solutions

    Energy Technology Data Exchange (ETDEWEB)

    Degasperis, A [Dipartimento di Fisica, Universita di Roma ' La Sapienza' , and Istituto Nazionale di Fisica Nucleare, Sezione di Roma, Rome (Italy); Lombardo, S [School of Mathematics, University of Manchester, Alan Turing Building, Upper Brook Street, Manchester M13 9EP (United Kingdom)], E-mail: antonio.degasperis@roma1.infn.it, E-mail: sara.lombardo@manchester.ac.uk, E-mail: sara@few.vu.nl

    2009-09-25

    The Darboux-dressing transformations developed in Degasperis and Lombardo (2007 J. Phys. A: Math. Theor. 40 961-77) are here applied to construct soliton solutions for a class of boomeronic-type equations. The vacuum (i.e. vanishing) solution and the generic plane wave solution are both dressed to yield one-soliton solutions. The formulae are specialized to the particularly interesting case of the resonant interaction of three waves, a well-known model which is of boomeronic type. For this equation a novel solution which describes three locked dark pulses (simulton) is introduced.

  8. Integrable KP Coupling and Its Exact Solution

    Institute of Scientific and Technical Information of China (English)

    彭凌; 杨旭东; 楼森岳

    2012-01-01

    The integrable coupling is one of the most important topics in the nonlinear physics. This paper creates a novel integrable KP coupling and solves it via a recently-developed dark parameterization procedure.

  9. A Single-Chip Solar Energy Harvesting IC Using Integrated Photodiodes for Biomedical Implant Applications.

    Science.gov (United States)

    Chen, Zhiyuan; Law, Man-Kay; Mak, Pui-In; Martins, Rui P

    2017-02-01

    In this paper, an ultra-compact single-chip solar energy harvesting IC using on-chip solar cell for biomedical implant applications is presented. By employing an on-chip charge pump with parallel connected photodiodes, a 3.5 × efficiency improvement can be achieved when compared with the conventional stacked photodiode approach to boost the harvested voltage while preserving a single-chip solution. A photodiode-assisted dual startup circuit (PDSC) is also proposed to improve the area efficiency and increase the startup speed by 77%. By employing an auxiliary charge pump (AQP) using zero threshold voltage (ZVT) devices in parallel with the main charge pump, a low startup voltage of 0.25 V is obtained while minimizing the reversion loss. A 4 Vin gate drive voltage is utilized to reduce the conduction loss. Systematic charge pump and solar cell area optimization is also introduced to improve the energy harvesting efficiency. The proposed system is implemented in a standard 0.18- [Formula: see text] CMOS technology and occupies an active area of 1.54 [Formula: see text]. Measurement results show that the on-chip charge pump can achieve a maximum efficiency of 67%. With an incident power of 1.22 [Formula: see text] from a halogen light source, the proposed energy harvesting IC can deliver an output power of 1.65 [Formula: see text] at 64% charge pump efficiency. The chip prototype is also verified using in-vitro experiment.

  10. A case study: semantic integration of gene-disease associations for type 2 diabetes mellitus from literature and biomedical data resources.

    Science.gov (United States)

    Rebholz-Schuhmann, Dietrich; Grabmüller, Christoph; Kavaliauskas, Silvestras; Croset, Samuel; Woollard, Peter; Backofen, Rolf; Filsell, Wendy; Clark, Dominic

    2014-07-01

    In the Semantic Enrichment of the Scientific Literature (SESL) project, researchers from academia and from life science and publishing companies collaborated in a pre-competitive way to integrate and share information for type 2 diabetes mellitus (T2DM) in adults. This case study exposes benefits from semantic interoperability after integrating the scientific literature with biomedical data resources, such as UniProt Knowledgebase (UniProtKB) and the Gene Expression Atlas (GXA). We annotated scientific documents in a standardized way, by applying public terminological resources for diseases and proteins, and other text-mining approaches. Eventually, we compared the genetic causes of T2DM across the data resources to demonstrate the benefits from the SESL triple store. Our solution enables publishers to distribute their content with little overhead into remote data infrastructures, such as into any Virtual Knowledge Broker.

  11. Integrating semantic information into multiple kernels for protein-protein interaction extraction from biomedical literatures.

    Directory of Open Access Journals (Sweden)

    Lishuang Li

    Full Text Available Protein-Protein Interaction (PPI extraction is an important task in the biomedical information extraction. Presently, many machine learning methods for PPI extraction have achieved promising results. However, the performance is still not satisfactory. One reason is that the semantic resources were basically ignored. In this paper, we propose a multiple-kernel learning-based approach to extract PPIs, combining the feature-based kernel, tree kernel and semantic kernel. Particularly, we extend the shortest path-enclosed tree kernel (SPT by a dynamic extended strategy to retrieve the richer syntactic information. Our semantic kernel calculates the protein-protein pair similarity and the context similarity based on two semantic resources: WordNet and Medical Subject Heading (MeSH. We evaluate our method with Support Vector Machine (SVM and achieve an F-score of 69.40% and an AUC of 92.00%, which show that our method outperforms most of the state-of-the-art systems by integrating semantic information.

  12. An integrated biomedical knowledge extraction and analysis platform: using federated search and document clustering technology.

    Science.gov (United States)

    Taylor, Donald P

    2007-01-01

    High content screening (HCS) requires time-consuming and often complex iterative information retrieval and assessment approaches to optimally conduct drug discovery programs and biomedical research. Pre- and post-HCS experimentation both require the retrieval of information from public as well as proprietary literature in addition to structured information assets such as compound libraries and projects databases. Unfortunately, this information is typically scattered across a plethora of proprietary bioinformatics tools and databases and public domain sources. Consequently, single search requests must be presented to each information repository, forcing the results to be manually integrated for a meaningful result set. Furthermore, these bioinformatics tools and data repositories are becoming increasingly complex to use; typically they fail to allow for more natural query interfaces. Vivisimo has developed an enterprise software platform to bridge disparate silos of information. The platform automatically categorizes search results into descriptive folders without the use of taxonomies to drive the categorization. A new approach to information retrieval for HCS experimentation is proposed.

  13. Designing Integrated Product- Service System Solutions in Manufacturing Industries

    DEFF Research Database (Denmark)

    Costa, Nina; Patrício, Lia; Morelli, Nicola

    2015-01-01

    Manufacturing firms are increasingly evolving towards the design of integrated product-service solutions but servitization literature does not provide specific guidance on how to design these integrated solutions. Building upon ProductService System (PSS) and Service Design (SD) approaches...... how it brings new insights to manufacturing companies moving to a service, value cocreation perspective....

  14. Designing Integrated Product- Service System Solutions in Manufacturing Industries

    DEFF Research Database (Denmark)

    Costa, Nina; Patrício, Lia; Morelli, Nicola

    2015-01-01

    Manufacturing firms are increasingly evolving towards the design of integrated product-service solutions but servitization literature does not provide specific guidance on how to design these integrated solutions. Building upon ProductService System (PSS) and Service Design (SD) approaches......, this paper proposes an integrative method that joins PSS’s systems and network approach with the creative, human-centered, value cocreation approach of SD. The paper also describes the development and application of this method to the creation of integrated solutions for the laboratory industry, highlighting...

  15. Electrochemical behavior of near-beta titanium biomedical alloys in phosphate buffer saline solution.

    Science.gov (United States)

    Dalmau, A; Guiñón Pina, V; Devesa, F; Amigó, V; Igual Muñoz, A

    2015-03-01

    The electrochemical behavior of three different near-β titanium alloys (composed by Ti, Nb and Sn) obtained by powder metallurgy for biomedical applications has been investigated. Different electrochemical and microscopy techniques were used to study the influence of the chemical composition (Sn content) and the applied potential on the microstructure and the corrosion mechanisms of those titanium alloys. The addition of Sn below 4wt.% to the titanium powder improves the microstructural homogeneity and generates an alloy with high corrosion resistance with low elastic modulus, being more suitable as a biomaterial. When the Sn content is above 4%, the corrosion resistance considerably decreases by increasing the passive dissolution rate; this effect is enhanced with the applied potential.

  16. Tribocorrosion behavior of beta titanium biomedical alloys in phosphate buffer saline solution.

    Science.gov (United States)

    Pina, V Guiñón; Dalmau, A; Devesa, F; Amigó, V; Muñoz, A Igual

    2015-06-01

    The tribo-electrochemical behavior of different β titanium alloys for biomedical applications sintered by powder metallurgy has been investigated. Different mechanical, electrochemical and optical techniques were used to study the influence of the chemical composition, Sn content, and the electrochemical conditions on the tribocorrosion behavior of those alloys Ti30NbxSn alloys (where "x" is the weight percentage of Sn content, 2% and 4%). Sn content increases the active and passive dissolution rate of the titanium alloys, thus increasing the mechanically activated corrosion under tribocorrosion conditions. It also increases the mechanical wear of the alloy. Prevailing electrochemical conditions between -1 and 2V influences the wear accelerated corrosion by increasing it with the applied potential and slightly increases the mechanical wear of Ti30Nb4Sn. Wear accelerated corrosion can be predicted by existing models as a function of electrochemical and mechanical parameters of the titanium alloys.

  17. PubFocus: semantic MEDLINE/PubMed citations analytics through integration of controlled biomedical dictionaries and ranking algorithm

    Directory of Open Access Journals (Sweden)

    Chuong Cheng-Ming

    2006-10-01

    Full Text Available Abstract Background Understanding research activity within any given biomedical field is important. Search outputs generated by MEDLINE/PubMed are not well classified and require lengthy manual citation analysis. Automation of citation analytics can be very useful and timesaving for both novices and experts. Results PubFocus web server automates analysis of MEDLINE/PubMed search queries by enriching them with two widely used human factor-based bibliometric indicators of publication quality: journal impact factor and volume of forward references. In addition to providing basic volumetric statistics, PubFocus also prioritizes citations and evaluates authors' impact on the field of search. PubFocus also analyses presence and occurrence of biomedical key terms within citations by utilizing controlled vocabularies. Conclusion We have developed citations' prioritisation algorithm based on journal impact factor, forward referencing volume, referencing dynamics, and author's contribution level. It can be applied either to the primary set of PubMed search results or to the subsets of these results identified through key terms from controlled biomedical vocabularies and ontologies. NCI (National Cancer Institute thesaurus and MGD (Mouse Genome Database mammalian gene orthology have been implemented for key terms analytics. PubFocus provides a scalable platform for the integration of multiple available ontology databases. PubFocus analytics can be adapted for input sources of biomedical citations other than PubMed.

  18. Local integration: a durable solution for refugees?

    Directory of Open Access Journals (Sweden)

    Ana Low

    2006-05-01

    Full Text Available UNHCR supports local integration as one possiblesolution for refugees who cannot return home. Experiencein Mexico, Uganda and Zambia indicates that integrationcan benefi t refugee-hosting communities as well asrefugees.

  19. Local integration: reviving a forgotten solution

    Directory of Open Access Journals (Sweden)

    Alexandra Fielden

    2008-04-01

    Full Text Available A combination of historical trends, the changing policies ofgovernments and renewed efforts by UNHCR have all begunto strengthen the potential of local integration as a lastingsolution for refugees.

  20. Supply chain integration:challenges and solutions

    OpenAIRE

    Sweeney, Edward

    2011-01-01

    Since its introduction by management consultants in the early 1980s, supply chain management (SCM) has been primarily concerned with the integration of processes and activities both within and between organisations. The concept of supply chain integration (SCI) is based on documented evidence that suggests that much of the waste throughout businesses is a consequence of fragmented supply chain configurations. However, there is also evidence to suggest that the achievement of higher levels of ...

  1. An Integrated Chip High-Voltage Power Receiver for Wireless Biomedical Implants

    Directory of Open Access Journals (Sweden)

    Vijith Vijayakumaran Nair

    2015-06-01

    Full Text Available In near-field wireless-powered biomedical implants, the receiver voltage largely overrides the compliance of low-voltage power receiver systems. To limit the induced voltage, generally, low-voltage topologies utilize limiter circuits, voltage clippers or shunt regulators, which are power-inefficient methods. In order to overcome the voltage limitation and improve power efficiency, we propose an integrated chip high-voltage power receiver based on the step down approach. The topology accommodates voltages as high as 30 V and comprises a high-voltage semi-active rectifier, a voltage reference generator and a series regulator. Further, a battery management circuit that enables safe and reliable implant battery charging based on analog control is proposed and realized. The power receiver is fabricated in 0.35-μm high-voltage Bipolar-CMOS-DMOStechnology based on the LOCOS0.35-μm CMOS process. Measurement results indicate 83.5% power conversion efficiency for a rectifier at 2.1 mA load current. The low drop-out regulator based on the current buffer compensation and buffer impedance attenuation scheme operates with low quiescent current, reduces the power consumption and provides good stability. The topology also provides good power supply rejection, which is adequate for the design application. Measurement results indicate regulator output of 4 ± 0.03 V for input from 5 to 30 V and 10 ± 0.05 V output for input from 11 to 30 V with load current 0.01–100 mA. The charger circuit manages the charging of the Li-ion battery through all if the typical stages of the Li-ion battery charging profile.

  2. A Closed Form Solution for an Unorthodox Trigonometric Integral

    Science.gov (United States)

    Wu, Yan

    2009-01-01

    A closed form solution for the trigonometric integral [integral]sec[superscript 2k+1]xdx, k=0,1,2,..., is presented in this article. The result will fill the gap in another trigonometric integral [integral]sec[superscript 2m+1] x tan[superscript 2n]xdx, which is neglected by most of the calculus textbooks due to its foreseeable unorthodox solution…

  3. Solutions to Integration Model of Rural Information Resources

    Institute of Scientific and Technical Information of China (English)

    Xirong; GAO; Bo; TAO

    2014-01-01

    The integration of rural information resources is a key factor restricting rural informationization and effective operation of rural information services. To solve problems of separate rural information resources and departments acting willfully regardless of overall interest,this paper analyzed characteristics and distribution of rural information resources,built a basic framework for integration of rural information resources and a mathematic model of integration,and finally came up with specific solutions to integration of rural information resources.

  4. A Closed Form Solution for an Unorthodox Trigonometric Integral

    Science.gov (United States)

    Wu, Yan

    2009-01-01

    A closed form solution for the trigonometric integral [integral]sec[superscript 2k+1]xdx, k=0,1,2,..., is presented in this article. The result will fill the gap in another trigonometric integral [integral]sec[superscript 2m+1] x tan[superscript 2n]xdx, which is neglected by most of the calculus textbooks due to its foreseeable unorthodox solution…

  5. The RICORDO approach to semantic interoperability for biomedical data and models: strategy, standards and solutions

    Directory of Open Access Journals (Sweden)

    Wimalaratne Sarala

    2011-08-01

    Full Text Available Abstract Background The practice and research of medicine generates considerable quantities of data and model resources (DMRs. Although in principle biomedical resources are re-usable, in practice few can currently be shared. In particular, the clinical communities in physiology and pharmacology research, as well as medical education, (i.e. PPME communities are facing considerable operational and technical obstacles in sharing data and models. Findings We outline the efforts of the PPME communities to achieve automated semantic interoperability for clinical resource documentation in collaboration with the RICORDO project. Current community practices in resource documentation and knowledge management are overviewed. Furthermore, requirements and improvements sought by the PPME communities to current documentation practices are discussed. The RICORDO plan and effort in creating a representational framework and associated open software toolkit for the automated management of PPME metadata resources is also described. Conclusions RICORDO is providing the PPME community with tools to effect, share and reason over clinical resource annotations. This work is contributing to the semantic interoperability of DMRs through ontology-based annotation by (i supporting more effective navigation and re-use of clinical DMRs, as well as (ii sustaining interoperability operations based on the criterion of biological similarity. Operations facilitated by RICORDO will range from automated dataset matching to model merging and managing complex simulation workflows. In effect, RICORDO is contributing to community standards for resource sharing and interoperability.

  6. Path Integral Solution by Sum Over Perturbation Series

    CERN Document Server

    Lin, D H

    1999-01-01

    A method for calculating the relativistic path integral solution via sum over perturbation series is given. As an application the exact path integral solution of the relativistic Aharonov-Bohm-Coulomb system is obtained by the method. Different from the earlier treatment based on the space-time transformation and infinite multiple-valued trasformation of Kustaanheimo-Stiefel in order to perform path integral, the method developed in this contribution involves only the explicit form of a simple Green's function and an explicit path integral is avoided.

  7. Bounds for solutions to retarded nonlinear double integral inequalities

    Directory of Open Access Journals (Sweden)

    Sabir Hussain

    2014-12-01

    Full Text Available We present bounds for the solution to three types retarded nonlinear integral inequalities in two variables. By doing this, we generalizing the results presented in [3,12]. To illustrate our results, we present some applications.

  8. Compressive cyclic ratcheting and fatigue of synthetic, soft biomedical polymers in solution.

    Science.gov (United States)

    Miller, Andrew T; Safranski, David L; Smith, Kathryn E; Guldberg, Robert E; Gall, Ken

    2016-02-01

    The use of soft, synthetic materials for the replacement of soft, load-bearing tissues has been largely unsuccessful due to a lack of materials with sufficient fatigue and wear properties, as well as a lack of fundamental understanding on the relationship between material structure and behavior under cyclic loads. In this study, we investigated the response of several soft, biomedical polymers to cyclic compressive stresses under aqueous conditions and utilized dynamic mechanical analysis and differential scanning calorimetry to evaluate the role of thermo-mechanical transitions on such behavior. Studied materials include: polycarbonate urethane, polydimethylsiloxane, four acrylate copolymers with systematically varied thermo-mechanical transitions, as well as bovine meniscal tissue for comparison. Materials showed compressive moduli between 2.3 and 1900MPa, with polycarbonate urethane (27.3MPa) matching closest to meniscal tissue (37.0MPa), and also demonstrated a variety of thermo-mechanical transition behaviors. Cyclic testing resulted in distinct fatigue-life curves, with failure defined as either classic fatigue fracture or a defined increased in maximum strain due to ratcheting. Our study found that polymers with sufficient dissipation mechanisms at the testing temperature, as evidenced by tan delta values, were generally tougher than those with less dissipation and exhibited ratcheting rather than fatigue fracture much like meniscal tissue. Strain recovery tests indicated that, for some toughened polymers, the residual strain following our cyclic loading protocol could be fully recovered. The similarity in ratcheting behavior, and lack of fatigue fracture, between the meniscal tissue and toughened polymers indicates that such polymers may have potential as artificial soft tissue.

  9. Integrated Frequency Synthesis for Convergent Wireless Solutions

    CERN Document Server

    Atallah, Jad G

    2012-01-01

    This book describes the design and implementation of an electronic subsystem called the frequency synthesizer, which is a very important building block for any wireless transceiver. The discussion includes several new techniques for the design of such a subsystem which include the usage modes of the wireless device, including its support for several leading-edge wireless standards. This new perspective for designing such a demanding subsystem is based on the fact that optimizing the performance of a complete system is not always achieved by optimizing the performance of its building blocks separately.  This book provides “hands-on” examples of this sort of co-design of optimized subsystems, which can make the vision of an always-best-connected scenario a reality. Provides up-to-date design information regarding one of the most complex subsystems used in state-of-the-art wireless devices; Describes a wireless front-end solution designed to provide an always-best-connected solution, based on a wireless det...

  10. TECHNOLOGY SOLUTIONS FOR WIND INTEGRATION IN ERCOT

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2015-01-03

    Texas has for more than a decade led all other states in the U.S. with the most wind generation capacity on the U.S. electric grid. The State recognized the value that wind energy could provide, and committed early on to build out the transmission system necessary to move power from the windy regions in West Texas to the major population centers across the state. It also signaled support for renewables on the grid by adopting an aggressive renewable portfolio standard (RPS). The joining of these conditions with favorable Federal tax credits has driven the rapid growth in Texas wind capacity since its small beginning in 2000. In addition to the major transmission grid upgrades, there have been a number of technology and policy improvements that have kept the grid reliable while adding more and more intermittent wind generation. Technology advancements such as better wind forecasting and deployment of a nodal market system have improved the grid efficiency of wind. Successful large scale wind integration into the electric grid, however, continues to pose challenges. The continuing rapid growth in wind energy calls for a number of technology additions that will be needed to reliably accommodate an expected 65% increase in future wind resources. The Center for the Commercialization of Electric Technologies (CCET) recognized this technology challenge in 2009 when it submitted an application for funding of a regional demonstration project under the Recovery Act program administered by the U.S. Department of Energy1. Under that program the administration announced the largest energy grid modernization investment in U.S. history, making available some $3.4 billion in grants to fund development of a broad range of technologies for a more efficient and reliable electric system, including the growth of renewable energy sources like wind and solar. At that time, Texas was (and still is) the nation’s leader in the integration of wind into the grid, and was investing heavily

  11. Technology solutions for wind integration in Ercot

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2015-02-23

    Texas has for more than a decade led all other states in the U.S. with the most wind generation capacity on the U.S. electric grid. The State recognized the value that wind energy could provide, and committed early on to build out the transmission system necessary to move power from the windy regions in West Texas to the major population centers across the state. It also signaled support for renewables on the grid by adopting an aggressive renewable portfolio standard (RPS). The joining of these conditions with favorable Federal tax credits has driven the rapid growth in Texas wind capacity since its small beginning in 2000. In addition to the major transmission grid upgrades, there have been a number of technology and policy improvements that have kept the grid reliable while adding more and more intermittent wind generation. Technology advancements such as better wind forecasting and deployment of a nodal market system have improved the grid efficiency of wind. Successful large scale wind integration into the electric grid, however, continues to pose challenges. The continuing rapid growth in wind energy calls for a number of technology additions that will be needed to reliably accommodate an expected 65% increase in future wind resources. The Center for the Commercialization of Electric Technologies (CCET) recognized this technology challenge in 2009 when it submitted an application for funding of a regional demonstration project under the Recovery Act program administered by the U.S. Department of Energy1. Under that program the administration announced the largest energy grid modernization investment in U.S. history, making available some $3.4 billion in grants to fund development of a broad range of technologies for a more efficient and reliable electric system, including the growth of renewable energy sources like wind and solar. At that time, Texas was (and still is) the nation’s leader in the integration of wind into the grid, and was investing heavily

  12. Technology solutions for wind integration in ERCOT

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2015-01-03

    Texas has for more than a decade led all other states in the U.S. with the most wind generation capacity on the U.S. electric grid. The State recognized the value that wind energy could provide, and committed early on to build out the transmission system necessary to move power from the windy regions in West Texas to the major population centers across the state. It also signaled support for renewables on the grid by adopting an aggressive renewable portfolio standard (RPS). The joining of these conditions with favorable Federal tax credits has driven the rapid growth in Texas wind capacity since its small beginning in 2000. In addition to the major transmission grid upgrades, there have been a number of technology and policy improvements that have kept the grid reliable while adding more and more intermittent wind generation. Technology advancements such as better wind forecasting and deployment of a nodal market system have improved the grid efficiency of wind. Successful large scale wind integration into the electric grid, however, continues to pose challenges. The continuing rapid growth in wind energy calls for a number of technology additions that will be needed to reliably accommodate an expected 65% increase in future wind resources. The Center for the Commercialization of Electric Technologies (CCET) recognized this technology challenge in 2009 when it submitted an application for funding of a regional demonstration project under the Recovery Act program administered by the U.S. Department of Energy1. Under that program the administration announced the largest energy grid modernization investment in U.S. history, making available some $3.4 billion in grants to fund development of a broad range of technologies for a more efficient and reliable electric system, including the growth of renewable energy sources like wind and solar. At that time, Texas was (and still is) the nation’s leader in the integration of wind into the grid, and was investing heavily

  13. Integral Equation Solution for Biopotentials of Single Cells

    Science.gov (United States)

    Klee, Maurice; Plonsey, Robert

    1972-01-01

    A Fredholm integral equation of the second type is developed for the biopotentials of single cells. Two singularities arise in the numerical solution of this integral equation and methods for handling them are presented. The problem of a spherical cell in an applied uniform field is used to illustrate the technique. PMID:4655666

  14. Integrating Behavioral HIV Interventions into Biomedical Prevention Trials with Youth: Lessons from Chicago's Project PrEPare.

    Science.gov (United States)

    Hosek, Sybil G; Green, Keith R; Siberry, George; Lally, Michelle; Balthazar, Christopher; Serrano, Pedro A; Kapogiannis, Bill

    2013-01-01

    On the heels of several trials demonstrating the efficacy of pre-exposure prophylaxis (PrEP) and the recent approval by the FDA of the supplemental indication for Truvada as PrEP, researchers, advocates, and community providers are calling for the investigation of implementation strategies that combine behavioral interventions with biomedical prevention. This paper describes the modification and integration of an evidence-based group-level intervention into a small PrEP pilot trial with young men who have sex with men (YMSM). The behavioral intervention as well as ongoing risk reduction counseling sessions were found to be highly acceptable among a sample of racially diverse YMSM.

  15. Data integration and knowledge discovery in biomedical databases. Reliable information from unreliable sources

    Directory of Open Access Journals (Sweden)

    A Mitnitski

    2003-01-01

    Full Text Available To better understand information about human health from databases we analyzed three datasets collected for different purposes in Canada: a biomedical database of older adults, a large population survey across all adult ages, and vital statistics. Redundancy in the variables was established, and this led us to derive a generalized (macroscopic state variable, being a fitness/frailty index that reflects both individual and group health status. Evaluation of the relationship between fitness/frailty and the mortality rate revealed that the latter could be expressed in terms of variables generally available from any cross-sectional database. In practical terms, this means that the risk of mortality might readily be assessed from standard biomedical appraisals collected for other purposes.

  16. A service-oriented distributed semantic mediator: integrating multiscale biomedical information.

    Science.gov (United States)

    Mora, Oscar; Engelbrecht, Gerhard; Bisbal, Jesus

    2012-11-01

    Biomedical research continuously generates large amounts of heterogeneous and multimodal data spread over multiple data sources. These data, if appropriately shared and exploited, could dramatically improve the research practice itself, and ultimately the quality of health care delivered. This paper presents DISMED (DIstributed Semantic MEDiator), an open source semantic mediator that provides a unified view of a federated environment of multiscale biomedical data sources. DISMED is a Web-based software application to query and retrieve information distributed over a set of registered data sources, using semantic technologies. It also offers a userfriendly interface specifically designed to simplify the usage of these technologies by non-expert users. Although the architecture of the software mediator is generic and domain independent, in the context of this paper, DISMED has been evaluated for managing biomedical environments and facilitating research with respect to the handling of scientific data distributed in multiple heterogeneous data sources. As part of this contribution, a quantitative evaluation framework has been developed. It consist of a benchmarking scenario and the definition of five realistic use-cases. This framework, created entirely with public datasets, has been used to compare the performance of DISMED against other available mediators. It is also available to the scientific community in order to evaluate progress in the domain of semantic mediation, in a systematic and comparable manner. The results show an average improvement in the execution time by DISMED of 55% compared to the second best alternative in four out of the five use-cases of the experimental evaluation.

  17. Influence of the substitutional solute on the mechanical properties of Ti-Nb binary alloys for biomedical use

    Directory of Open Access Journals (Sweden)

    Luciano Monteiro da Silva

    2012-06-01

    Full Text Available Titanium alloys are widely used in the manufacture of biomedical implants because they possess an excellent combination of physical properties and outstanding biocompatibility. Today, the most widely used alloy is Ti-6Al-4V, but some studies have reported adverse effects with the long-term presence of Al and V in the body, without mentioning that the elasticity modulus value of this alloy is far superior to the bone. Thus, there is a need to develop new Ti-based alloys without Al and V that have a lower modulus, greater biocompatibility, and similar mechanical strength. In this paper, we investigated the effect of Nb as a substitutional solute on the mechanical properties of Ti-Nb alloys, prepared in an arc-melting furnace and characterized by density, X-ray diffraction, optical microscopy, hardness and elasticity modulus measurements. The X-ray and microscopy measurements show a predominance of the α phase. The microhardness values showed a tendency to increase with the concentration of niobium in the alloy. Regarding the elasticity modulus, it was observed a nonlinear behavior with respect to the concentration of niobium. This behavior is associated with the presence of the α phase.

  18. Ontology-Oriented Programming for Biomedical Informatics.

    Science.gov (United States)

    Lamy, Jean-Baptiste

    2016-01-01

    Ontologies are now widely used in the biomedical domain. However, it is difficult to manipulate ontologies in a computer program and, consequently, it is not easy to integrate ontologies with databases or websites. Two main approaches have been proposed for accessing ontologies in a computer program: traditional API (Application Programming Interface) and ontology-oriented programming, either static or dynamic. In this paper, we will review these approaches and discuss their appropriateness for biomedical ontologies. We will also present an experience feedback about the integration of an ontology in a computer software during the VIIIP research project. Finally, we will present OwlReady, the solution we developed.

  19. Developing an integrated biomedical and behavioural theory of functioning and disability: adding models of behaviour to the ICF framework.

    Science.gov (United States)

    Johnston, Marie; Dixon, Diane

    2014-01-01

    The International Classification of Functioning Disability and Health (ICF) offers an agreed language on which a scientific model of functional outcomes can be built. The ICF defines functional outcomes as activity and activity limitations (AL) and defines both in behavioural terms. The ICF, therefore, appears to invite explanations of AL as behaviours. Studies of AL find that psychological variables, especially perceptions of control, add to biomedical variables in predicting AL. Therefore, two improved models are proposed, which integrate the ICF with two psychological theories, the theory of planned behaviour (TPB) and social cognitive theory (SCT). These models have a sound evidence base as good predictors of behaviour, include perceived control constructs and are compatible with existing evidence about AL. When directly tested in studies of community and clinic-based populations, both integrated models (ICF/TPB and ICF/SCT) outperform each of the three basic models (ICF, TPB and SCT). However, when predicting activity rather than AL, the biomedical model of the ICF does not improve prediction of activity by TPB and SCT on their own. It is concluded that these models offer a better explanation of functional outcomes than the ICF alone and could form the basis for the development of improved models.

  20. Adomian solution of a nonlinear quadratic integral equation

    Directory of Open Access Journals (Sweden)

    E.A.A. Ziada

    2013-04-01

    Full Text Available We are concerned here with a nonlinear quadratic integral equation (QIE. The existence of a unique solution will be proved. Convergence analysis of Adomian decomposition method (ADM applied to these type of equations is discussed. Convergence analysis is reliable enough to estimate the maximum absolute truncated error of Adomian’s series solution. Two methods are used to solve these type of equations; ADM and repeated trapezoidal method. The obtained results are compared.

  1. The Stem Cell Commons: an exemplar for data integration in the biomedical domain driven by the ISA framework.

    Science.gov (United States)

    Ho Sui, Shannan; Merrill, Emily; Gehlenborg, Nils; Haseley, Psalm; Sytchev, Ilya; Park, Richard; Rocca-Serra, Philippe; Corlosquet, Stephane; Gonzalez-Beltran, Alejandra; Maguire, Eamonn; Hofmann, Oliver; Park, Peter; Das, Sudeshna; Sansone, Susanna-Assunta; Hide, Winston

    2013-01-01

    Comparisons of stem cell experiments at both molecular and semantic levels remain challenging due to inconsistencies in results, data formats, and descriptions among biomedical research discoveries. The Harvard Stem Cell Institute (HSCI) has created the Stem Cell Commons (stemcellcommons.org), an open, community-based approach to data sharing. Experimental information is integrated using the Investigation-Study-Assay tabular format (ISA-Tab) used by over 30 organizations (ISA Commons, isacommons.org). The early adoption of this format permitted the novel integration of three independent systems to facilitate stem cell data storage, exchange and analysis: the Blood Genomics Repository, the Stem Cell Discovery Engine, and the new Refinery platform that links the Galaxy analytical engine to data repositories.

  2. Surface integrals approach to solution of some free boundary problems

    Directory of Open Access Journals (Sweden)

    Igor Malyshev

    1988-01-01

    Full Text Available Inverse problems in which it is required to determine the coefficients of an equation belong to the important class of ill-posed problems. Among these, of increasing significance, are problems with free boundaries. They can be found in a wide range of disciplines including medicine, materials engineering, control theory, etc. We apply the integral equations techniques, typical for parabolic inverse problems, to the solution of a generalized Stefan problem. The regularization of the corresponding system of nonlinear integral Volterra equations, as well as local existence, uniqueness, continuation of its solution, and several numerical experiments are discussed.

  3. Positive and Nontrivial Solutions for the Urysohn Integral Equation

    Institute of Scientific and Technical Information of China (English)

    Daniel FRANCO; Gennaro INFANTE; Donal O'REGAN

    2006-01-01

    We establish new criteria for the existence of either positive or nonzero solutions of the Urysohn integral equation. We also discuss the existence of an interval of positive eigenvalues and sufficient conditions for the existence of at least a positive eigenvalue with a nonzero or positive eigenfunction for the Urysohn integral operator. Among others, we employ techniques based on fixed point index theory for compact maps, which are new for this type of equation.

  4. Nonzero solutions of nonlinear integral equations modeling infectious disease

    Energy Technology Data Exchange (ETDEWEB)

    Williams, L.R. (Indiana Univ., South Bend); Leggett, R.W.

    1982-01-01

    Sufficient conditions to insure the existence of periodic solutions to the nonlinear integral equation, x(t) = ..integral../sup t//sub t-tau/f(s,x(s))ds, are given in terms of simple product and product integral inequalities. The equation can be interpreted as a model for the spread of infectious diseases (e.g., gonorrhea or any of the rhinovirus viruses) if x(t) is the proportion of infectives at time t and f(t,x(t)) is the proportion of new infectives per unit time.

  5. Exploring the integration of the biomedical research component in undergraduate medical education.

    Science.gov (United States)

    van Schravendijk, C; März, R; Garcia-Seoane, J

    2013-06-01

    A task force of MEDINE (Thematic Network on Medical Education in Europe) organized a survey of European Medical Schools. To investigate the link between education and biomedical research in the medical curriculum questioning university staff responsible for the curriculum. The survey was online between 10/2006 and 3/2007. Answers pertained to the situation in the academic year 2005/06. Ninety-one medical schools/faculties in 26 countries participated, but response rates to some questions were lower due to incomplete responses. In undergraduate programs, 3/4 of the schools offer research courses and in 2/3 students can do research themselves. However, in most schools, fewer than 10% students choose this option. In about half the medical schools writing a thesis is a requirement for graduation, although the term "thesis" is interpreted broadly. Color map analysis revealed the link between medical education and biomedical research: about 25% of the medical schools had little emphasis on research in their undergraduate curriculum. We identified the curriculum elements most suitable to improve the link between medical education and research for the initial stage (years 1-3) as literature search techniques, statistics and epidemiology, while for the advanced stage (years 4-6), writing a thesis was most relevant.

  6. Integrating Contemplative Tools into Biomedical Science Education and Research Training Programs

    Directory of Open Access Journals (Sweden)

    Rodney R. Dietert

    2014-01-01

    Full Text Available Academic preparation of science researchers and/or human or veterinary medicine clinicians through the science, technology, engineering, and mathematics (STEM curriculum has usually focused on the students (1 acquiring increased disciplinary expertise, (2 learning needed methodologies and protocols, and (3 expanding their capacity for intense, persistent focus. Such educational training is effective until roadblocks or problems arise via this highly-learned approach. Then, the health science trainee may have few tools available for effective problem solving. Training to achieve flexibility, adaptability, and broadened perspectives using contemplative practices has been rare among biomedical education programs. To address this gap, a Cornell University-based program involving formal biomedical science coursework, and health science workshops has been developed to offer science students, researchers and health professionals a broader array of personal, contemplation-based, problem-solving tools. This STEM educational initiative includes first-person exercises designed to broaden perceptional awareness, decrease emotional drama, and mobilize whole-body strategies for creative problem solving. Self-calibration and journaling are used for students to evaluate the personal utility of each exercise. The educational goals are to increase student self-awareness and self-regulation and to provide trainees with value-added tools for career-long problem solving. Basic elements of this educational initiative are discussed using the framework of the Tree of Contemplative Practices.

  7. Properties of Solutions of BSDEs with Integrable Parameters

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The main result of this study is to obtain, using the localization method in Briand et al[3]. Levi, Fatou and Lebesgue type theorems for the solutions of certain one-dimensional backward stochastic differential equation (BSDEs) with integrable parameters with respect to the terminal condition.

  8. An Integrated Supply Chain Solution for Theater Distribution

    Science.gov (United States)

    2009-02-17

    5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Colonel Ronda G. Urey Department of Military Strategy, Planning, and...PROJECT AN INTEGRATED SUPPLY CHAIN SOLUTION FOR THEATER DISTRIBUTION by Colonel Mark A. McCormick United States Army Colonel Ronda G. Urey Project

  9. Biomedical engineering principles

    CERN Document Server

    Ritter, Arthur B; Valdevit, Antonio; Ascione, Alfred N

    2011-01-01

    Introduction: Modeling of Physiological ProcessesCell Physiology and TransportPrinciples and Biomedical Applications of HemodynamicsA Systems Approach to PhysiologyThe Cardiovascular SystemBiomedical Signal ProcessingSignal Acquisition and ProcessingTechniques for Physiological Signal ProcessingExamples of Physiological Signal ProcessingPrinciples of BiomechanicsPractical Applications of BiomechanicsBiomaterialsPrinciples of Biomedical Capstone DesignUnmet Clinical NeedsEntrepreneurship: Reasons why Most Good Designs Never Get to MarketAn Engineering Solution in Search of a Biomedical Problem

  10. Integrated computational and conceptual solutions for complex environmental information management

    Science.gov (United States)

    Rückemann, Claus-Peter

    2016-06-01

    This paper presents the recent results of the integration of computational and conceptual solutions for the complex case of environmental information management. The solution for the major goal of creating and developing long-term multi-disciplinary knowledge resources and conceptual and computational support was achieved by implementing and integrating key components. The key components are long-term knowledge resources providing required structures for universal knowledge creation, documentation, and preservation, universal multi-disciplinary and multi-lingual conceptual knowledge and classification, especially, references to Universal Decimal Classification (UDC), sustainable workflows for environmental information management, and computational support for dynamical use, processing, and advanced scientific computing with Integrated Information and Computing System (IICS) components and High End Computing (HEC) resources.

  11. Designing a socio-economic assessment method for integrative biomedical research: the Osteoporotic Virtual Physiological Human project.

    Science.gov (United States)

    Thiel, Rainer; Stroetmann, Karl A; Stroetmann, Veli N; Viceconti, Marco

    2009-01-01

    In integrative biomedical research, methods assessing the clinical or even socio-economic impact of more complex technologies such as Information and Communication Technology (ICT)-based tools for modelling and simulation of human physiology have rarely been applied. The EU funded Osteoporotic Virtual Physiological Human (VPHOP) research project, part of the Virtual Physiological Human (VPH) European initiative, will create a patient-specific hypermodel to predict the absolute risk of bone fracture much more accurately than predictions based on current clinical practice. The project has developed an innovative, multilevel generic methodological framework to assess the clinical and socio-economic impact of biocomputational models. The assessment framework consists of three components: a socio-economic cost benefit analysis, health economic analysis of care pathways, and disease cost simulation models. Through its holistic perspective, the method provides a tool to appraise the overall value of biocomputational models for society.

  12. Trends in SCADA solutions applied to wind energy integration

    Energy Technology Data Exchange (ETDEWEB)

    Eichler, Roland [Siemens AG (Germany); Lorimer, Martin [Siemens Ltd. (United Kingdom); Romero Velazquez, Manuel [Siemens S.A. (Spain)

    2010-07-01

    Monitoring and control of wind parks - whether onshore or offshore - is done on three levels: at the first level a wind park SCADA deals with individual wind turbines, at an intermediate level SCADA oversees large wind parks or several smaller ones with their grid connection, and on the system operator level SCADA/EMS mainly addresses system stability. The paper focuses on SCADA solutions applied to the intermediate level. The goal of the paper is to identify different stages of wind park integration both from an organization/rules point of view and from a technical point of view. This is done on the basis of wind park projects in Europe. Besides others, the paper identifies technical trends in SCADA systems, system architecture, communication media, and communication protocols (incl. IEC 61850). Technical solutions applied, of course, reflect the organizational framework in the respective country/market. The paper identifies general requirements on SCADA solutions for wind energy integration that allow largely standardized solutions. This leads to faster and more economic solutions. An outlook includes standards not yet seen in grid level SCADA systems such as IEC 61400-25. (orig.)

  13. SQL Server 2012 data integration recipes solutions for integration services and other ETL tools

    CERN Document Server

    Aspin, Adam

    2012-01-01

    SQL Server 2012 Data Integration Recipes provides focused and practical solutions to real world problems of data integration. Need to import data into SQL Server from an outside source? Need to export data and send it to another system? SQL Server 2012 Data Integration Recipes has your back. You'll find solutions for importing from Microsoft Office data stores such as Excel and Access, from text files such as CSV files, from XML, from other database brands such as Oracle and MySQL, and even from other SQL Server databases. You'll learn techniques for managing metadata, transforming data to mee

  14. The Theory of Bio-Medical Knowledge Integration(Ⅷ)——The Intrinsic Medical Informatics(IMI) and Meta-dimensions(MDs) of SNOMED

    Institute of Scientific and Technical Information of China (English)

    BAO Han-fei

    2008-01-01

    This paper presented the profile of Intrinsic Medical Informatics(IMI), which consists of Medical Cognition Informatics(MCI) and Organism Informatics (OI). MCI and OI are taken as two cornerstones of the Theory of BioMedical Knowledge Integration(BMKI). Additionally, so called Meta-dimension architecture of SNOMED is discussed in order to venture its context computing.

  15. INTEGRATED DOCUMENT MANAGEMENT SOLUTION FOR THE LOCAL GOVERNMENT

    Directory of Open Access Journals (Sweden)

    Nistor Razvan

    2013-07-01

    Full Text Available In this paper we present system analysis and design elements for the integrated document management solution at local governing authorities in the rural areas. While specifically dealing with the actual management of the Agricultural Register, an important primary unitary evidence document, we also keep a general character of the discussion, in order to argue for the generality of the proposed solution. Hence, for the identified and described problem space we propose an administrative and software infrastructure solution. This work is an empirical research in which our aim is primarily to identify key problems within the local governing authorities from several perspectives concerning the management of the Agricultural Register then to address those problems with an integrated document management system. For the proposed solution we give and argue the general system architecture and describe the key-mechanisms that support quality requirements. The relevance of this research concern is given by the impact of the actual Agricultural Register management on important stakeholders. This can be measured as the satisfaction felt by taxpayers and the performance of the local governing authorities, the Financial Administration, the Agency of Payments and Intervention in Agriculture and the Ministry of Agriculture and Rural Development. This work is also intended as a start-point for a new, modern thinking of the governing authorities in their pursue to improve public services. For this, in our work we highlight the importance of complete system analysis at all administrative levels as a main priority concern for all public managers. Our aim is the improvement of the public service by rising the awareness of the decision makers on the necessity of using integrated document management solutions for the provided services. Also, our work aims at increasing the efficiency with which nowadays, governing authorities invest public funds in various IT projects

  16. The Explicit Solutions of Riccati Equation by Integral Series

    CERN Document Server

    Yan, Yimin

    2010-01-01

    The paper aims at exactly solving the linear differential equation and the matrix Riccati equation with variable coefficients. Starting with the simplest structure of them, this article promotes the exponential function by introducing two maps with integral series: $\\mathcal{E}(X)$ and $\\mathcal{F}(X)$, which extend the important properties of exponential function: convergence, reversibility, and the relationship of determinant. Then,the article shows two approaches to the Riccati equation solving: (1)one is the Simplified Way: summed up the Riccati equation into the simplest form $\\frac{\\partial}{\\partial x}W+WPW-Q=0$, and gets the accurate solution;(2) the other is Matrix Way: directly deal with the general Riccati equation, and transform into the matrix linear differential equation. And then the solution could be further expresses with the elementary form with the particular solution. At the end, we can see that Riccati equation solving is somehow a particular case of linear differential equation when view...

  17. Challenges and trends in magnetic sensor integration with microfluidics for biomedical applications

    Science.gov (United States)

    Cardoso, S.; Leitao, D. C.; Dias, T. M.; Valadeiro, J.; Silva, M. D.; Chicharo, A.; Silverio, V.; Gaspar, J.; Freitas, P. P.

    2017-06-01

    Magnetoresistive (MR) sensors have been successfully applied in many technologies, in particular readout electronics and smart systems for multiple signal addressing and readout. When single sensors are used, the requirements relate to spatial resolution and localized field sources. The integration of MR sensors in adaptable media (e.g. flexible, stretchable substrates) offers the possibility to merge the magnetic detection with mechanical functionalities. In addition, the precision of a micrometric needle can benefit greatly from the integration of MR sensors with submicrometric resolution. In this paper, we demonstrate through several detailed examples how advanced MR sensors can be integrated with the systems described above, and also with microfluidic technologies. Here, the challenges of handling liquids over a chip combine with those for miniaturization of microelectronics for MR readout. However, when these are overcome, the result is an integrated system with added functionalities, capable of answering the demand in biomedicine and biochemistry for lab-on-a-chip devices.

  18. Integrated Computational Solution for Predicting Skin Sensitization Potential of Molecules.

    Directory of Open Access Journals (Sweden)

    Konda Leela Sarath Kumar

    Full Text Available Skin sensitization forms a major toxicological endpoint for dermatology and cosmetic products. Recent ban on animal testing for cosmetics demands for alternative methods. We developed an integrated computational solution (SkinSense that offers a robust solution and addresses the limitations of existing computational tools i.e. high false positive rate and/or limited coverage.The key components of our solution include: QSAR models selected from a combinatorial set, similarity information and literature-derived sub-structure patterns of known skin protein reactive groups. Its prediction performance on a challenge set of molecules showed accuracy = 75.32%, CCR = 74.36%, sensitivity = 70.00% and specificity = 78.72%, which is better than several existing tools including VEGA (accuracy = 45.00% and CCR = 54.17% with 'High' reliability scoring, DEREK (accuracy = 72.73% and CCR = 71.44% and TOPKAT (accuracy = 60.00% and CCR = 61.67%. Although, TIMES-SS showed higher predictive power (accuracy = 90.00% and CCR = 92.86%, the coverage was very low (only 10 out of 77 molecules were predicted reliably.Owing to improved prediction performance and coverage, our solution can serve as a useful expert system towards Integrated Approaches to Testing and Assessment for skin sensitization. It would be invaluable to cosmetic/ dermatology industry for pre-screening their molecules, and reducing time, cost and animal testing.

  19. Wear transition of solid-solution-strengthened Ti-29Nb-13Ta-4.6Zr alloys by interstitial oxygen for biomedical applications.

    Science.gov (United States)

    Lee, Yoon-Seok; Niinomi, Mitsuo; Nakai, Masaaki; Narita, Kengo; Cho, Ken; Liu, Huihong

    2015-11-01

    In previous studies, it has been concluded that volume losses (V loss) of the Ti-29Nb-13Ta-4.6Zr (TNTZ) discs and balls are larger than those of the respective Ti-6Al-4V extra-low interstitial (Ti64) discs and balls, both in air and Ringer's solution. These results are related to severe subsurface deformation of TNTZ, which is caused by the lower resistance to plastic shearing of TNTZ than that of Ti64. Therefore, it is necessary to further increase the wear resistance of TNTZ to satisfy the requirements as a biomedical implant. From this viewpoint, interstitial oxygen was added to TNTZ to improve the plastic shear resistance via solid-solution strengthening. Thus, the wear behaviors of combinations comprised of a new titanium alloy, TNTZ with high oxygen content of 0.89 mass% (89O) and a conventional titanium alloy, Ti64 were investigated in air and Ringer's solution for biomedical implant applications. The worn surfaces, wear debris, and subsurface damage were analyzed using a scanning electron microscopy and an electron probe microanalysis. V loss of the 89O discs and balls are smaller than those of the respective TNTZ discs and balls in both air and Ringer's solution. It can be concluded that the solid-solution strengthening by oxygen effectively improves the wear resistance for TNTZ materials. However, the 89O disc/ball combination still exhibits higher V loss than the Ti64 disc/ball combination in both air and Ringer's solution. Moreover, V loss of the disc for the 89O disc/Ti64 ball combination significantly decreases in Ringer's solution compared to that in air. This decrease for the 89O disc/Ti64 ball combination in Ringer's solution can be explained by the transition in the wear mechanism from severe delamination wear to abrasive wear.

  20. Integrated primary health care: Finnish solutions and experiences

    Directory of Open Access Journals (Sweden)

    Simo Kokko

    2009-06-01

    Full Text Available Background: Finland has since 1972 had a primary health care system based on health centres run and funded by the local public authorities called ‘municipalities’. On the world map of primary health care systems, the Finnish solution claims to be the most health centre oriented and also the widest, both in terms of the numbers of staff and also of different professions employed. Offering integrated care through multi-professional health centres has been overshadowed by exceptional difficulties in guaranteeing a reasonable access to the population at times when they need primary medical or dental services. Solutions to the problems of access have been found, but they do not seem durable. Description of policy practice: During the past 10 years, the health centres have become a ground of active development structural change, for which no end is in sight. Broader issues of municipal and public administration structures are being solved through rearranging primary health services. In these rearrangements, integration with specialist services and with social services together with mergers of health centres and municipalities are occurring at an accelerated pace. This leads into fundamental questions of the benefits of integration, especially if extensive integration leads into the threat of the loss of identity for primary health care. Discussion: This article ends with some lessons to be learned from the situation in Finland for other countries.

  1. Integrating clinical medicine into biomedical graduate education to promote translational research: strategies from two new PhD programs.

    Science.gov (United States)

    Smith, Carolyn L; Jarrett, Marcia; Bierer, S Beth

    2013-01-01

    For several decades, a barrier has existed between research and clinical medicine, making it difficult for aspiring scientists to gain exposure to human pathophysiology and access to clinical/translational research mentors during their graduate training. In 2005, the Howard Hughes Medical Institute announced the Med Into Grad initiative to support graduate programs that integrate clinical knowledge into PhD biomedical training, with the goal of preparing a new cadre of translational researchers to work at the interface of the basic sciences and clinical medicine. Two institutions, Baylor College of Medicine and the Cleveland Clinic/Case Western Reserve University, developed new PhD programs in translational biology and/or molecular medicine. These programs teach the topics and skills that today's translational researchers must learn and expose students to clinical medicine. In this article, the authors compare and contrast the history, implementation, and evaluation of the Translational Biology and Molecular Medicine program at Baylor College of Medicine and the Molecular Medicine program at the Cleveland Clinic/Case Western Reserve University. The authors also demonstrate the feasibility of creating a multidisciplinary graduate program in molecular medicine that integrates pathophysiology and clinical medicine without extending training time. They conclude with a discussion of the similarities in training approaches that exist despite the fact that each program was independently developed and offer observations that emerged during their collaboration that may benefit others who are considering developing similar programs.

  2. Can holism be practiced in a biomedical setting? A qualitative study of the integration of complementary medicine to a surgical department.

    Science.gov (United States)

    Keshet, Yael; Ben-Arye, Eran; Schiff, Elad

    2012-11-01

    In recent decades, complementary medicine (CM) has been increasingly integrated to conventional healthcare organizations, in which the biomedical profession clearly maintains dominance. Our objective was to investigate empirically what integration and 'holism' mean to the diverse professional groups involved and whether treatment becomes more holistic when CM is integrated. A qualitative study was conducted in a general surgery department at a public hospital in Israel. Data were collected by means of observations of medical encounters and daily work, and 30 in-depth interviews with medical directors, surgeons, senior nurses, CM practitioners and hospitalized patients. We found that most of the interviewed nurses, surgeons and directors and some patients believed that CM treatments were of value in addressing the psychological needs of patients within this predominantly somatic-oriented department. To CM practitioners and some of the patients, integration means introducing and practicing a holistic outlook in this biomedical context, which involves elements such as Qi, energy, soul and spirit. Such practices were directed to a suitable audience, namely, patients as well as conventional medical staff who were willing to explore a holistic approach. We concluded that patient care tends to become more comprehensive when CM is integrated. Despite the overall dominance of biomedicine, holistic CM practices were introduced to the biomedical setting of the hospital. Yet, the question whether holistic CM practices and perceptions will eventually lead nurses and physicians toward paradigmatic integration, has still to be examined.

  3. Some integral identities involving products of general solutions of Bessel's equation of integral order

    CERN Document Server

    Auluck, S K H

    2010-01-01

    Spectral decomposition of dynamical equations using curl-eigenfunctions has been extensively used in fluid and plasma dynamics problems using their orthogonality and completeness properties for both linear and non-linear cases. Coefficients of such expansions are integrals over products of Bessel functions in problems involving cylindrical geometry. In this paper, certain identities involving products of two and three general solutions of Bessel's equation have been derived. Some of these identities have been useful in the study of Turner relaxation of annular magnetized plasma [S.K.H. Auluck, Phys. Plasmas, 16, 122504, 2009], where quadratic integral quantities such as helicity and total energy were expressed as algebraic functions of the arbitrary constants of the general solution of Bessel's equation, allowing their determination by a minimization procedure. Identities involving products of three solutions enable expanding a product of two solutions in a Fourier-Bessel series of single Bessel functions fac...

  4. Summary of Curriculum Units: Health and Biomedical Science Program of Study Integrated Curriculum Units

    Science.gov (United States)

    ConnectEd: The California Center for College and Career, 2008

    2008-01-01

    Successful Linked Learning pathways depend on curricula and instruction that challenge students to reach high academic standards through relevant and engaging content. These pathways offer an "integrated curriculum" that connects challenging, college-preparatory material to career-based technical concepts and applications. Teachers in…

  5. Mouse anatomy ontologies: enhancements and tools for exploring and integrating biomedical data.

    Science.gov (United States)

    Hayamizu, Terry F; Baldock, Richard A; Ringwald, Martin

    2015-10-01

    Mouse anatomy ontologies provide standard nomenclature for describing normal and mutant mouse anatomy, and are essential for the description and integration of data directly related to anatomy such as gene expression patterns. Building on our previous work on anatomical ontologies for the embryonic and adult mouse, we have recently developed a new and substantially revised anatomical ontology covering all life stages of the mouse. Anatomical terms are organized in complex hierarchies enabling multiple relationships between terms. Tissue classification as well as partonomic, developmental, and other types of relationships can be represented. Hierarchies for specific developmental stages can also be derived. The ontology forms the core of the eMouse Atlas Project (EMAP) and is used extensively for annotating and integrating gene expression patterns and other data by the Gene Expression Database (GXD), the eMouse Atlas of Gene Expression (EMAGE) and other database resources. Here we illustrate the evolution of the developmental and adult mouse anatomical ontologies toward one combined system. We report on recent ontology enhancements, describe the current status, and discuss future plans for mouse anatomy ontology development and application in integrating data resources.

  6. Explicit solution of Calderon preconditioned time domain integral equations

    KAUST Repository

    Ulku, Huseyin Arda

    2013-07-01

    An explicit marching on-in-time (MOT) scheme for solving Calderon-preconditioned time domain integral equations is proposed. The scheme uses Rao-Wilton-Glisson and Buffa-Christiansen functions to discretize the domain and range of the integral operators and a PE(CE)m type linear multistep to march on in time. Unlike its implicit counterpart, the proposed explicit solver requires the solution of an MOT system with a Gram matrix that is sparse and well-conditioned independent of the time step size. Numerical results demonstrate that the explicit solver maintains its accuracy and stability even when the time step size is chosen as large as that typically used by an implicit solver. © 2013 IEEE.

  7. SOLUTIONS FOR INTEGRATED ADMINISTRATION OF URBAN GREEN AREAS

    Directory of Open Access Journals (Sweden)

    ADINA CLAUDIA NEAMTU

    2014-05-01

    Full Text Available This paper aims to provide an administrative model for green spaces in any geographical area, especially in urban areas. The organizational proposed model also concerns the possibilities to develop new areas with green spaces for both recreation and leisure. Current structures leave much to be desired and, unfortunately, they do not seek to manage the green spaces on types of activities and these activities are not integrated into a unit structure to ensure coordination of operations for maintenance and expansion of these spaces. In the study, for the administrative plan are proposed those necessary changes to create organizational structures needed to implement a coherent strategy and policy to support the development of green space. Given the necessity of an integrated management for urban space, the model proposes solutions to eliminate functional overlaps of the various decision-making bodies by creating a unit of action, together with arrangements for its effective support. Developing effective solutions to managing green spaces for recreation and leisure becomes an obligation for the next period under conditions of increasing green areas arranged as parks and other types of green spaces and hence an increase for the cost of their administration. On the other hand, the paper addresses the issue of integrated management for both, green areas and recreational and leisure facilities existing within the urban areas, by giving more importance and impact for these spaces within communities. In this framework of integrated administration, it is possible to ensure modern leisure amenities in these urban green areas, and on the other hand it is possible to provide a very important prospect of additional revenues for the general budget of the community and also for future budget of planning for new green areas.

  8. Nanowire-organic thin film transistor integration and scale up towards developing sensor array for biomedical sensing applications

    Science.gov (United States)

    Kumar, Prashanth S.; Hankins, Phillip T.; Rai, Pratyush; Varadan, Vijay K.

    2010-04-01

    Exploratory research works have demonstrated the capability of conducting nanowire arrays in enhancing the sensitivity and selectivity of bio-electrodes in sensing applications. With the help of different surface manipulation techniques, a wide range of biomolecules have been successfully immobilized on these nanowires. Flexible organic electronics, thin film transistor (TFT) fabricated on flexible substrate, was a breakthrough that enabled development of logic circuits on flexible substrate. In many health monitoring scenarios, a series of biomarkers, physical properties and vital signals need to be observed. Since the nano-bio-electrodes are capable of measuring all or most of them, it has been aptly suggested that a series of electrode (array) on single substrate shall be an excellent point of care tool. This requires an efficient control system for signal acquisition and telemetry. An array of flexible TFTs has been designed that acts as active matrix for controlled switching of or scanning by the sensor array. This array is a scale up of the flexible organic TFT that has been fabricated and rigorously tested in previous studies. The integration of nanowire electrodes to the organic electronics was approached by growing nanowires on the same substrate as TFTs and fl ip chip packaging, where the nanowires and TFTs are made on separate substrates. As a proof of concept, its application has been explored in various multi-focal biomedical sensing applications, such as neural probes for monitoring neurite growth, dopamine, and neuron activity; myocardial ischemia for spatial monitoring of myocardium.

  9. Beyond the biomedical and behavioural: towards an integrated approach to HIV prevention in the southern African mining industry.

    Science.gov (United States)

    Campbell, C; Williams, B

    1999-06-01

    While migrant labour is believed to play an important role in the dynamics of HIV-transmission in many of the countries of southern Africa, little has been written about the way in which HIV/AIDS has been dealt with in the industrial settings in which many migrant workers are employed. This paper takes the gold mining industry in the countries of the Southern African Development Community (SADC) as a case study. While many mines made substantial efforts to establish HIV-prevention programmes relatively early on in the epidemic, these appear to have had little impact. The paper analyses the response of key players in the mining industry, in the interests of highlighting the limitations of the way in which both managements and trade unions have responded to HIV. It will be argued that the energy that has been devoted either to biomedical or behavioural prevention programmes or to human rights issues has served to obscure the social and developmental dimensions of HIV-transmission. This argument is supported by means of a case study which seeks to highlight the complexity of the dynamics of disease transmission in this context, a complexity which is not reflected in individualistic responses. An account is given of a new intervention which seeks to develop a more integrated approach to HIV management in an industrial setting.

  10. The Enterprise Data Trust at Mayo Clinic: a semantically integrated warehouse of biomedical data.

    Science.gov (United States)

    Chute, Christopher G; Beck, Scott A; Fisk, Thomas B; Mohr, David N

    2010-01-01

    Mayo Clinic's Enterprise Data Trust is a collection of data from patient care, education, research, and administrative transactional systems, organized to support information retrieval, business intelligence, and high-level decision making. Structurally it is a top-down, subject-oriented, integrated, time-variant, and non-volatile collection of data in support of Mayo Clinic's analytic and decision-making processes. It is an interconnected piece of Mayo Clinic's Enterprise Information Management initiative, which also includes Data Governance, Enterprise Data Modeling, the Enterprise Vocabulary System, and Metadata Management. These resources enable unprecedented organization of enterprise information about patient, genomic, and research data. While facile access for cohort definition or aggregate retrieval is supported, a high level of security, retrieval audit, and user authentication ensures privacy, confidentiality, and respect for the trust imparted by our patients for the respectful use of information about their conditions.

  11. The Enterprise Data Trust at Mayo Clinic: a semantically integrated warehouse of biomedical data

    Science.gov (United States)

    Beck, Scott A; Fisk, Thomas B; Mohr, David N

    2010-01-01

    Mayo Clinic's Enterprise Data Trust is a collection of data from patient care, education, research, and administrative transactional systems, organized to support information retrieval, business intelligence, and high-level decision making. Structurally it is a top-down, subject-oriented, integrated, time-variant, and non-volatile collection of data in support of Mayo Clinic's analytic and decision-making processes. It is an interconnected piece of Mayo Clinic's Enterprise Information Management initiative, which also includes Data Governance, Enterprise Data Modeling, the Enterprise Vocabulary System, and Metadata Management. These resources enable unprecedented organization of enterprise information about patient, genomic, and research data. While facile access for cohort definition or aggregate retrieval is supported, a high level of security, retrieval audit, and user authentication ensures privacy, confidentiality, and respect for the trust imparted by our patients for the respectful use of information about their conditions. PMID:20190054

  12. Integrated secure solution for electronic healthcare records sharing

    Science.gov (United States)

    Yao, Yehong; Zhang, Chenghao; Sun, Jianyong; Jin, Jin; Zhang, Jianguo

    2007-03-01

    The EHR is a secure, real-time, point-of-care, patient-centric information resource for healthcare providers. Many countries and regional districts have set long-term goals to build EHRs, and most of EHRs are usually built based on the integration of different information systems with different information models and platforms. A number of hospitals in Shanghai are also piloting the development of an EHR solution based on IHE XDS/XDS-I profiles with a service-oriented architecture (SOA). The first phase of the project targets the Diagnostic Imaging domain and allows seamless sharing of images and reports across the multiple hospitals. To develop EHRs for regional coordinated healthcare, some factors should be considered in designing architecture, one of which is security issue. In this paper, we present some approaches and policies to improve and strengthen the security among the different hospitals' nodes, which are compliant with the security requirements defined by IHE IT Infrastructure (ITI) Technical Framework. Our security solution includes four components: Time Sync System (TSS), Digital Signature Manage System (DSMS), Data Exchange Control Component (DECC) and Single Sign-On (SSO) System. We give a design method and implementation strategy of these security components, and then evaluate the performance and overheads of the security services or features by integrating the security components into an image-based EHR system.

  13. Integration of Social, Cultural, and Biomedical Strategies into an Existing Couple-Based Behavioral HIV/STI Prevention Intervention: Voices of Latino Male Couples.

    Directory of Open Access Journals (Sweden)

    Omar Martinez

    Full Text Available Successful HIV prevention and treatment requires evidence-based approaches that combine biomedical strategies with behavioral interventions that are socially and culturally appropriate for the population or community being prioritized. Although there has been a push for a combination approach, how best to integrate different strategies into existing behavioral HIV prevention interventions remains unclear. The need to develop effective combination approaches is of particular importance for men who have sex with men (MSM, who face a disproportionately high risk of HIV acquisition.We collaborated with Latino male couples and providers to adapt Connect 'n Unite, an evidence-based intervention for Black male couples, for Latino male couples. We conducted a series of three focus groups, each with two cohorts of couples, and one focus group with providers. A purposive stratified sample of 20 couples (N = 40, divided into two cohorts and 10 providers provided insights into how to adapt and integrate social, cultural, and biomedical approaches in a couples-based HIV/AIDS behavioral intervention.The majority (N = 37 of the couple participants had no prior knowledge of the following new biomedical strategies: non-occupational post-exposure prophylaxis (nPEP; pre-exposure prophylaxis (PrEP; and HIV self-testing kits. After they were introduced to these biomedical interventions, all participants expressed a need for information and empowerment through knowledge and awareness of these interventions. In particular, participants suggested that we provide PrEP and HIV self-testing kits by the middle or end of the intervention. Providers suggested a need to address behavioral, social and structural issues, such as language barriers; and the promotion of client-centered approaches to increase access to, adaptation of, and adherence to biomedical strategies. Corroborating what couple participants suggested, providers agreed that biomedical strategies should be

  14. Integration of Social, Cultural, and Biomedical Strategies into an Existing Couple-Based Behavioral HIV/STI Prevention Intervention: Voices of Latino Male Couples.

    Science.gov (United States)

    Martinez, Omar; Wu, Elwin; Levine, Ethan C; Muñoz-Laboy, Miguel; Fernandez, M Isabel; Bass, Sarah Bauerle; Moya, Eva M; Frasca, Timothy; Chavez-Baray, Silvia; Icard, Larry D; Ovejero, Hugo; Carballo-Diéguez, Alex; Rhodes, Scott D

    2016-01-01

    Successful HIV prevention and treatment requires evidence-based approaches that combine biomedical strategies with behavioral interventions that are socially and culturally appropriate for the population or community being prioritized. Although there has been a push for a combination approach, how best to integrate different strategies into existing behavioral HIV prevention interventions remains unclear. The need to develop effective combination approaches is of particular importance for men who have sex with men (MSM), who face a disproportionately high risk of HIV acquisition. We collaborated with Latino male couples and providers to adapt Connect 'n Unite, an evidence-based intervention for Black male couples, for Latino male couples. We conducted a series of three focus groups, each with two cohorts of couples, and one focus group with providers. A purposive stratified sample of 20 couples (N = 40, divided into two cohorts) and 10 providers provided insights into how to adapt and integrate social, cultural, and biomedical approaches in a couples-based HIV/AIDS behavioral intervention. The majority (N = 37) of the couple participants had no prior knowledge of the following new biomedical strategies: non-occupational post-exposure prophylaxis (nPEP); pre-exposure prophylaxis (PrEP); and HIV self-testing kits. After they were introduced to these biomedical interventions, all participants expressed a need for information and empowerment through knowledge and awareness of these interventions. In particular, participants suggested that we provide PrEP and HIV self-testing kits by the middle or end of the intervention. Providers suggested a need to address behavioral, social and structural issues, such as language barriers; and the promotion of client-centered approaches to increase access to, adaptation of, and adherence to biomedical strategies. Corroborating what couple participants suggested, providers agreed that biomedical strategies should be offered after

  15. Towards the integration of mouse databases - definition and implementation of solutions to two use-cases in mouse functional genomics.

    Science.gov (United States)

    Gruenberger, Michael; Alberts, Rudi; Smedley, Damian; Swertz, Morris; Schofield, Paul; Schughart, Klaus

    2010-01-22

    The integration of information present in many disparate biological databases represents a major challenge in biomedical research. To define the problems and needs, and to explore strategies for database integration in mouse functional genomics, we consulted the biologist user community and implemented solutions to two user-defined use-cases. We organised workshops, meetings and used a questionnaire to identify the needs of biologist database users in mouse functional genomics. As a result, two use-cases were developed that can be used to drive future designs or extensions of mouse databases. Here, we present the use-cases and describe some initial computational solutions for them. The application for the gene-centric use-case, "MUSIG-Gen" starts from a list of gene names and collects a wide range of data types from several distributed databases in a "shopping cart"-like manner. The iterative user-driven approach is a response to strongly articulated requests from users, especially those without computational biology backgrounds. The application for the phenotype-centric use-case, "MUSIG-Phen", is based on a similar concept and starting from phenotype descriptions retrieves information for associated genes. The use-cases created, and their prototype software implementations should help to better define biologists' needs for database integration and may serve as a starting point for future bioinformatics solutions aimed at end-user biologists.

  16. Towards the integration of mouse databases - definition and implementation of solutions to two use-cases in mouse functional genomics

    Directory of Open Access Journals (Sweden)

    Schofield Paul

    2010-01-01

    Full Text Available Abstract Background The integration of information present in many disparate biological databases represents a major challenge in biomedical research. To define the problems and needs, and to explore strategies for database integration in mouse functional genomics, we consulted the biologist user community and implemented solutions to two user-defined use-cases. Results We organised workshops, meetings and used a questionnaire to identify the needs of biologist database users in mouse functional genomics. As a result, two use-cases were developed that can be used to drive future designs or extensions of mouse databases. Here, we present the use-cases and describe some initial computational solutions for them. The application for the gene-centric use-case, "MUSIG-Gen" starts from a list of gene names and collects a wide range of data types from several distributed databases in a "shopping cart"-like manner. The iterative user-driven approach is a response to strongly articulated requests from users, especially those without computational biology backgrounds. The application for the phenotype-centric use-case, "MUSIG-Phen", is based on a similar concept and starting from phenotype descriptions retrieves information for associated genes. Conclusion The use-cases created, and their prototype software implementations should help to better define biologists' needs for database integration and may serve as a starting point for future bioinformatics solutions aimed at end-user biologists.

  17. Integrated planning aimed at sustainability city logistics solutions

    Directory of Open Access Journals (Sweden)

    Tadić Snežana R.

    2015-01-01

    Full Text Available The main objective of city logistics system is sustainability, or efficiency, wide acceptability, environmental protection and safety. On the other hand, the city logistics system is very complex. It is characterized by a large number of participants, with different, usually conflicting goals and complex interactions. In addition, the system of city logistics is part of a wider system of the town, the region, and there are complex interactions with the external environment. The system depends on the specific characteristics of the city, affects other forms of urban mobility and is subject to the policies of higher rank (regional, national policy. Given the exceptional complexity, sustainable city logistics solution requires an integrated approach in all phases of planning, from stages of problem identification, definition of alternative solutions and effects assessment, to implementation and by exploitation. In this way, the solution of city logistics is becoming widely accepted and not only affects the efficiency of the socio-economic system of town, already on the sustainability of the whole region.

  18. The INTEGRATE project: Delivering solutions for efficient multi-centric clinical research and trials.

    Science.gov (United States)

    Kondylakis, Haridimos; Claerhout, Brecht; Keyur, Mehta; Koumakis, Lefteris; van Leeuwen, Jasper; Marias, Kostas; Perez-Rey, David; De Schepper, Kristof; Tsiknakis, Manolis; Bucur, Anca

    2016-08-01

    The objective of the INTEGRATE project (http://www.fp7-integrate.eu/) that has recently concluded successfully was the development of innovative biomedical applications focused on streamlining the execution of clinical research, on enabling multidisciplinary collaboration, on management and large-scale sharing of multi-level heterogeneous datasets, and on the development of new methodologies and of predictive multi-scale models in cancer. In this paper, we present the way the INTEGRATE consortium has approached important challenges such as the integration of multi-scale biomedical data in the context of post-genomic clinical trials, the development of predictive models and the implementation of tools to facilitate the efficient execution of postgenomic multi-centric clinical trials in breast cancer. Furthermore, we provide a number of key "lessons learned" during the process and give directions for further future research and development.

  19. A Wireless Pressure Sensor Integrated with a Biodegradable Polymer Stent for Biomedical Applications

    Directory of Open Access Journals (Sweden)

    Jongsung Park

    2016-06-01

    Full Text Available This paper describes the fabrication and characterization of a wireless pressure sensor for smart stent applications. The micromachined pressure sensor has an area of 3.13 × 3.16 mm2 and is fabricated with a photosensitive SU-8 polymer. The wireless pressure sensor comprises a resonant circuit and can be used without the use of an internal power source. The capacitance variations caused by changes in the intravascular pressure shift the resonance frequency of the sensor. This change can be detected using an external antenna, thus enabling the measurement of the pressure changes inside a tube with a simple external circuit. The wireless pressure sensor is capable of measuring pressure from 0 mmHg to 230 mmHg, with a sensitivity of 0.043 MHz/mmHg. The biocompatibility of the pressure sensor was evaluated using cardiac cells isolated from neonatal rat ventricular myocytes. After inserting a metal stent integrated with the pressure sensor into a cardiovascular vessel of an animal, medical systems such as X-ray were employed to consistently monitor the condition of the blood vessel. No abnormality was found in the animal blood vessel for approximately one month. Furthermore, a biodegradable polymer (polycaprolactone stent was fabricated with a 3D printer. The polymer stent exhibits better sensitivity degradation of the pressure sensor compared to the metal stent.

  20. A Wireless Pressure Sensor Integrated with a Biodegradable Polymer Stent for Biomedical Applications.

    Science.gov (United States)

    Park, Jongsung; Kim, Ji-Kwan; Patil, Swati J; Park, Jun-Kyu; Park, SuA; Lee, Dong-Weon

    2016-06-02

    This paper describes the fabrication and characterization of a wireless pressure sensor for smart stent applications. The micromachined pressure sensor has an area of 3.13 × 3.16 mm² and is fabricated with a photosensitive SU-8 polymer. The wireless pressure sensor comprises a resonant circuit and can be used without the use of an internal power source. The capacitance variations caused by changes in the intravascular pressure shift the resonance frequency of the sensor. This change can be detected using an external antenna, thus enabling the measurement of the pressure changes inside a tube with a simple external circuit. The wireless pressure sensor is capable of measuring pressure from 0 mmHg to 230 mmHg, with a sensitivity of 0.043 MHz/mmHg. The biocompatibility of the pressure sensor was evaluated using cardiac cells isolated from neonatal rat ventricular myocytes. After inserting a metal stent integrated with the pressure sensor into a cardiovascular vessel of an animal, medical systems such as X-ray were employed to consistently monitor the condition of the blood vessel. No abnormality was found in the animal blood vessel for approximately one month. Furthermore, a biodegradable polymer (polycaprolactone) stent was fabricated with a 3D printer. The polymer stent exhibits better sensitivity degradation of the pressure sensor compared to the metal stent.

  1. Ongoing ethical issues concerning authorship in biomedical journals: an integrative review.

    Science.gov (United States)

    Kornhaber, Rachel Anne; McLean, Loyola M; Baber, Rodney J

    2015-01-01

    Health professionals publishing within the field of health sciences continue to experience issues concerning appropriate authorship, which have clinical, ethical, and academic implications. This integrative review sought to explore the key issues concerning authorship from a bioethical standpoint, aiming to explore the key features of the authorship debate. Studies were identified through an electronic search, using the PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Scopus databases of peer-reviewed research, published between 2009 and 2014, limited to English language research, with search terms developed to reflect the current issues of authorship. From among the 279 papers identified, 20 research papers met the inclusion criteria. Findings were compiled and then arranged to identify themes and relationships. The review incorporated a wide range of authorship issues encompassing equal-credited authors, honorary (guest/gift) and ghost authorship, perception/experiences of authorship, and guidelines/policies. This review suggests that the International Committee of Medical Journal Editors' (ICMJE) recommended guidelines for authorship are not reflected in current authorship practices within the domain of health sciences in both low-and high-impact-factor journals. This devaluing of the true importance of authorship has the potential to affect the validity of authorship, diminish the real contributions of the true authors, and negatively affect patient care.

  2. Integrable cosmological models with non-minimal coupling and bounce solutions

    CERN Document Server

    Pozdeeva, Ekaterina

    2016-01-01

    We remind the way to obtain integrable models with non-minimally coupled scalar fields. We are interesting to models with bounce solutions and compare bounce solutions in two known integrable models. We show that only one model has a bounce solution that tends to a stable de Sitter solution.

  3. Should Degree Programs in Biomedical and Health Informatics be Dedicated or Integrated? : Reflections and Recommendations after more than 40 Years of Medical Informatics Education at TU Braunschweig, including 10 Years of B.Sc. and 15 Years of M.Sc. Integrated Degree Curricula.

    Science.gov (United States)

    Haux, Reinhold; Marschollek, Michael; Wolf, Klaus-Hendrik; Zeisberg, Ute

    2017-07-01

    Education in biomedical and health informatics (BMHI) has been established in many countries throughout the world. For degree programs in BMHI we can distinguish between those that are completely stand-alone or dedicated to the discipline vs. those that are integrated within another program. After running integrated degree medical informatics programs at TU Braunschweig for 10 years at the B.Sc. and for 15 years at the M.Sc level, we (1) report about this educational approach, (2) analyze recommendations on, implementations of, and experiences with degree educational programs in BMHI worldwide, (3) summarize our lessons learned with the integrated approach at TU Braunschweig, and (4) suggest an answer to the question, whether degree programs in biomedical and health informatics should be dedicated or integrated. According to our experience at TU Braunschweig and based on our analysis of publications, there is a clear dominance of dedicated degree programs in BMHI. The specialization in medical informatics within a computer science program, as offered at TU Braunschweig, may be a good way of implementing an integrated, informatics-based approach to medical informatics, in particular if a dual degree option can be chosen. The option of curricula leading to double degrees, i.e. in this case to two separate degrees in computer science and in medical informatics might, however, be a better solution.

  4. Improved parallel solution techniques for the integral transport matrix method

    Energy Technology Data Exchange (ETDEWEB)

    Zerr, R. Joseph, E-mail: rjz116@psu.edu [Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, University Park, PA (United States); Azmy, Yousry Y., E-mail: yyazmy@ncsu.edu [Department of Nuclear Engineering, North Carolina State University, Burlington Engineering Laboratories, Raleigh, NC (United States)

    2011-07-01

    Alternative solution strategies to the parallel block Jacobi (PBJ) method for the solution of the global problem with the integral transport matrix method operators have been designed and tested. The most straightforward improvement to the Jacobi iterative method is the Gauss-Seidel alternative. The parallel red-black Gauss-Seidel (PGS) algorithm can improve on the number of iterations and reduce work per iteration by applying an alternating red-black color-set to the subdomains and assigning multiple sub-domains per processor. A parallel GMRES(m) method was implemented as an alternative to stationary iterations. Computational results show that the PGS method can improve on the PBJ method execution time by up to 10´ when eight sub-domains per processor are used. However, compared to traditional source iterations with diffusion synthetic acceleration, it is still approximately an order of magnitude slower. The best-performing cases are optically thick because sub-domains decouple, yielding faster convergence. Further tests revealed that 64 sub-domains per processor was the best performing level of sub-domain division. An acceleration technique that improves the convergence rate would greatly improve the ITMM. The GMRES(m) method with a diagonal block pre conditioner consumes approximately the same time as the PBJ solver but could be improved by an as yet undeveloped, more efficient pre conditioner. (author)

  5. Improved parallel solution techniques for the integral transport matrix method

    Energy Technology Data Exchange (ETDEWEB)

    Zerr, Robert J [Los Alamos National Laboratory; Azmy, Yousry Y [NORTH CAROLINA STATE UNIV.

    2010-11-23

    Alternative solution strategies to the parallel block Jacobi (PBJ) method for the solution of the global problem with the integral transport matrix method operators have been designed and tested. The most straightforward improvement to the Jacobi iterative method is the Gauss-Seidel alternative. The parallel red-black Gauss-Seidel (PGS) algorithm can improve on the number of iterations and reduce work per iteration by applying an alternating red-black color-set to the subdomains and assigning multiple sub-domains per processor. A parallel GMRES(m) method was implemented as an alternative to stationary iterations. Computational results show that the PGS method can improve on the PBJ method execution by up to {approx}50% when eight sub-domains per processor are used. However, compared to traditional source iterations with diffusion synthetic acceleration, it is still approximately an order of magnitude slower. The best-performing case are opticaUy thick because sub-domains decouple, yielding faster convergence. Further tests revealed that 64 sub-domains per processor was the best performing level of sub-domain division. An acceleration technique that improves the convergence rate would greatly improve the ITMM. The GMRES(m) method with a diagonal block preconditioner consumes approximately the same time as the PBJ solver but could be improved by an as yet undeveloped, more efficient preconditioner.

  6. New Exact Solutions of the Integrable Broer-Kaup Equations in (2+1)-Dimensional Spaces

    Institute of Scientific and Technical Information of China (English)

    LI De-Sheng; ZHANG Hong-Qing

    2004-01-01

    In this paper,by improving some procedure of extended tanh-function method,some new exact solutions to the integrable Broer-Kaup equations in(2 + 1)-dimensional spaces are obtained,which include soliton-like solutions,solitary wave solutions,trigonometric function solutions,and rational solutions.

  7. Solution processed integrated pixel element for an imaging device

    Science.gov (United States)

    Swathi, K.; Narayan, K. S.

    2016-09-01

    We demonstrate the implementation of a solid state circuit/structure comprising of a high performing polymer field effect transistor (PFET) utilizing an oxide layer in conjunction with a self-assembled monolayer (SAM) as the dielectric and a bulk-heterostructure based organic photodiode as a CMOS-like pixel element for an imaging sensor. Practical usage of functional organic photon detectors requires on chip components for image capture and signal transfer as in the CMOS/CCD architecture rather than simple photodiode arrays in order to increase speed and sensitivity of the sensor. The availability of high performing PFETs with low operating voltage and photodiodes with high sensitivity provides the necessary prerequisite to implement a CMOS type image sensing device structure based on organic electronic devices. Solution processing routes in organic electronics offers relatively facile procedures to integrate these components, combined with unique features of large-area, form factor and multiple optical attributes. We utilize the inherent property of a binary mixture in a blend to phase-separate vertically and create a graded junction for effective photocurrent response. The implemented design enables photocharge generation along with on chip charge to voltage conversion with performance parameters comparable to traditional counterparts. Charge integration analysis for the passive pixel element using 2D TCAD simulations is also presented to evaluate the different processes that take place in the monolithic structure.

  8. First Integrals, Integrating Factors, and Invariant Solutions of the Path Equation Based on Noether and -Symmetries

    Directory of Open Access Journals (Sweden)

    Gülden Gün

    2013-01-01

    Full Text Available We analyze Noether and -symmetries of the path equation describing the minimum drag work. First, the partial Lagrangian for the governing equation is constructed, and then the determining equations are obtained based on the partial Lagrangian approach. For specific altitude functions, Noether symmetry classification is carried out and the first integrals, conservation laws and group invariant solutions are obtained and classified. Then, secondly, by using the mathematical relationship with Lie point symmetries we investigate -symmetry properties and the corresponding reduction forms, integrating factors, and first integrals for specific altitude functions of the governing equation. Furthermore, we apply the Jacobi last multiplier method as a different approach to determine the new forms of -symmetries. Finally, we compare the results obtained from different classifications.

  9. Travelling wave solutions to nonlinear physical models by means of the first integral method

    Indian Academy of Sciences (India)

    İsmail Aslan Aslan

    2011-04-01

    This paper presents the first integral method to carry out the integration of nonlinear partial differential equations in terms of travelling wave solutions. For illustration, three important equations of mathematical physics are analytically investigated. Through the established first integrals, exact solutions are successfully constructed for the equations considered.

  10. On the integral representations of the Jost function and Coulomb off-shell Jost solution

    Indian Academy of Sciences (India)

    U Laha

    2006-08-01

    The integral representations of the Jost function (on- and off-shell) are rederived by the judicious use of the transposed operator relation on the particular integrals for Jost solution and using one of these particular integrals an analytical expression for the Coulomb off-shell Jost solution is presented in the maximal reduced form.

  11. ON DIRECT METHOD OF SOLUTION FOR A CLASS OF SINGULAR INTEGRAL EQUATIONS

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In this article, by introducing characteristic singular integral operator and associate singular integral equations (SIEs), the authors discuss the direct method of solution for a class of singular integral equations with certain analytic inputs. They obtain both the conditions of solvability and the solutions in closed form. It is noteworthy that the method is different from the classical one that is due to Lu.

  12. Comparative Studies of Electrospinning and Solution Blow Spinning Processes for the Production of Nanofibrous Poly(L-Lactic Acid Materials for Biomedical Engineering

    Directory of Open Access Journals (Sweden)

    Wojasiński Michal

    2014-06-01

    Full Text Available Comparative statistical analysis of the infiuence of processing parameters, for electrospinning (ES and solution blow spinning (SBS processes, on nanofibrous poly(L-lactic acid (PLLA material morphology and average fiber diameter was conducted in order to identify the key processing parameter for tailoring the product properties. Further, a comparative preliminary biocompatibility evaluation was performed. Based on Design of Experiment (DOE principles, analysis of standard effects of voltage, air pressure, solution feed rate and concentration, on nanofibers average diameter was performed with the Pareto’s charts and the best fitted surface charts. Nanofibers were analyzed by scanning electron microscopy (SEM. The preliminary biocompatibility comparative tests were performed based on SEM microphotographs of CP5 cells cultured on materials derived from ES and SBS. Polymer solution concentration was identified as the key parameter infiuencing morphology and dimensions of nanofibrous mat produced from both techniques. In both cases, when polymer concentration increases the average fiber diameter increase. The preliminary biocompatibility test suggests that nanofibers produced by ES as well as SBS are suitable as the biomedical engineering scaffold material.

  13. Exact Integral Solutions for Two-Phase Flow

    Science.gov (United States)

    McWhorter, David B.; Sunada, Daniel K.

    1990-03-01

    Exact integral solutions for the horizontal, unsteady flow of two viscous, incompressible fluids are derived. Both one-dimensional and radial displacements are calculated with full consideration of capillary drive and for arbitrary capillary-hydraulic properties. One-dimensional, unidirectional displacement of a nonwetting phase is shown to occur increasingly like a shock front as the pore-size distribution becomes wider. This is in contrast to the situation when an inviscid nonwetting phase is displaced. The penetration of a nonwetting phase into porous media otherwise saturated by a wetting phase occurs in narrow, elongate distributions. Such distributions result in rapid and extensive penetration by the nonwetting phase. The process is remarkably sensitive to the capillary-hydraulic properties that determine the value of knw/kw at large wetting phase saturations, a region in which laboratory measurements provide the least resolution. The penetration of a nonwetting phase can be expected to be dramatically affected by the presence of fissures, worm holes, or other macropores. Calculations for radial displacement of a nonwetting phase resident at a small initial saturation show the displacement to be inefficient. The fractional flow of the nonwetting phase falls rapidly and, for a specific example, becomes 1% by the time one pore volume of water has been injected.

  14. Integrating Free and Open Source Solutions into Geospatial Science Education

    Directory of Open Access Journals (Sweden)

    Vaclav Petras

    2015-06-01

    Full Text Available While free and open source software becomes increasingly important in geospatial research and industry, open science perspectives are generally less reflected in universities’ educational programs. We present an example of how free and open source software can be incorporated into geospatial education to promote open and reproducible science. Since 2008 graduate students at North Carolina State University have the opportunity to take a course on geospatial modeling and analysis that is taught with both proprietary and free and open source software. In this course, students perform geospatial tasks simultaneously in the proprietary package ArcGIS and the free and open source package GRASS GIS. By ensuring that students learn to distinguish between geospatial concepts and software specifics, students become more flexible and stronger spatial thinkers when choosing solutions for their independent work in the future. We also discuss ways to continually update and improve our publicly available teaching materials for reuse by teachers, self-learners and other members of the GIS community. Only when free and open source software is fully integrated into geospatial education, we will be able to encourage a culture of openness and, thus, enable greater reproducibility in research and development applications.

  15. Surface interactions of a W-DLC-coated biomedical AISI 316L stainless steel in physiological solution.

    Science.gov (United States)

    Antunes, Renato A; de Lima, Nelson Batista; Rizzutto, Márcia de Almeida; Higa, Olga Zazuco; Saiki, Mitiko; Costa, Isolda

    2013-04-01

    The corrosion stability of a W-DLC coated surgical AISI 316L stainless steel in Hanks' solution has been evaluated. Particle induced X-ray emission (PIXE) measurements were performed to evaluate the incorporation of potentially bioactive elements from the physiological solution. The film structure was analyzed by X-ray diffractometry and micro-Raman spectroscopy. The wear behavior was assessed using the sphere-on-disc geometry. The in vitro biocompatibility of the W-DLC film was evaluated by cytotoxicity tests. The corrosion resistance of the stainless steel substrate decreased in the presence of the PVD layer. EIS measurements suggest that this behavior was closely related to the corrosion attack through the coating pores. PIXE measurements revealed the presence of Ca and P in the W-DLC film after immersion in Hanks' solution. This result shows that the PIXE technique can be applied to identify and evaluate the incorporation of bioactive elements by W-DLC films. The film showed good wear resistance and biocompatibility.

  16. Interaction of solutions containing phenothiazines exposed to laser radiation with materials surfaces, in view of biomedical applications.

    Science.gov (United States)

    Simon, Agota; Alexandru, Tatiana; Boni, Mihai; Damian, Victor; Stoicu, Alexandru; Dutschk, Victoria; Pascu, Mihail Lucian

    2014-11-20

    Phenothiazine drugs - chlorpromazine (CPZ), promazine (PZ) and promethazine (PMZ) - were exposed to 266 nm (fourth harmonic of the Nd:YAG pulsed laser radiation) in order to be modified at molecular level and to produce an enhancement of their antibacterial activity. The irradiated samples were analysed by several methods: pH and surface tension measurements, UV-vis-NIR absorption spectroscopy, laser induced fluorescence and thin layer chromatography. The purpose of these investigations was to study and describe the modified properties of the medicines to further investigate their specific interactions with materials such as cotton, polyester and Parafilm M as a model smooth surface. The textile materials may be impregnated with phenothiazines drug solutions exposed to laser radiation in order to be used in treatments applied on the surface of the organism. Some of the phenothiazines solutions exposed prolonged time intervals to laser radiation have much better activity against several bacteria. Therefore, in the paper, it is reported the wetting behaviour of CPZ, PZ and PMZ solutions, irradiated for time intervals between 1 and 240 min, on the surfaces of the three textures in order to draw a conclusion about their wettability as a function of time.

  17. Existence of solutions to nonlinear Hammerstein integral equations and applications

    Science.gov (United States)

    Li, Fuyi; Li, Yuhua; Liang, Zhanping

    2006-11-01

    In this paper, we study the existence and multiplicity of solutions of the operator equation Kfu=u in the real Hilbert space L2(G). Under certain conditions on the linear operator K, we establish the conditions on f which are able to guarantee that the operator equation has at least one solution, a unique solution, and infinitely many solutions, respectively. The monotone operator principle and the critical point theory are employed to discuss this problem, respectively. In argument, quadratic root operator K1/2 and its properties play an important role. As an application, we investigate the existence and multiplicity of solutions to fourth-order boundary value problems for ordinary differential equations with two parameters, and give some new existence results of solutions.

  18. Advances in biomedical engineering

    CERN Document Server

    Brown, J H U

    1976-01-01

    Advances in Biomedical Engineering, Volume 6, is a collection of papers that discusses the role of integrated electronics in medical systems and the usage of biological mathematical models in biological systems. Other papers deal with the health care systems, the problems and methods of approach toward rehabilitation, as well as the future of biomedical engineering. One paper discusses the use of system identification as it applies to biological systems to estimate the values of a number of parameters (for example, resistance, diffusion coefficients) by indirect means. More particularly, the i

  19. On the Numerical Solution of One-Dimensional Integral and Differential Equations

    Science.gov (United States)

    1991-12-01

    Conditioned Weights 57 3.5 The Analytical Apparatus for Singular Solutions ................... 58 3.5.1 Notation...Algorithm for Singular Solutions .................. 81 3.7.1 Notation ........ .................................. 82 3.7.2 Discretization of the...Restricted Integral Equations ............. 84 3.7.3 Informal Description of the Algorithm for Singular Solutions . . .. 85 3.8 Description of the

  20. The Solution-Focused Debriefing Group: An Integrated Postviolence Group Intervention for Adults.

    Science.gov (United States)

    Juhnke, Gerald A.; Osborne, W. Larry

    1997-01-01

    Describes a solution-focused debriefing group model for adult survivors of violence, which integrates Critical Incident Stress Debriefing (CISD) and solution-focused counseling techniques. Discusses how to debrief team members, group size, the seven stages of CISD, and solution-focused debriefing group techniques. (RJM)

  1. A universal solution to one-dimensional oscillatory integrals

    Institute of Scientific and Technical Information of China (English)

    LI JianBing; WANG XueSong; WANG Tao

    2008-01-01

    How to calculate the highly oscillatory integrals is the bottleneck that restraints the research of light wave and electromagnetic wave's propagation and scattering.Levin method is a classical quadrature method for this type of integrals.Unfortunately it is susceptible to the system of linear equations' ill-conditioned behavior.We bring forward a universal quadrature method in this paper,which adopts Chebyshev differential matrix to solve the ordinary differential equation (ODE).This method can not only obtain the indefinite integral' function values directly,but also make the system of linear equations well-conditioned for general oscillatory integrals.Furthermore,even if the system of linear equations in our method is ill-conditioned,TSVD method can be adopted to solve them properly and eventually obtain accurate integral results,thus making a breakthrough in Levin method's susceptivity to the system of linear equations' ill-conditioned behavior.

  2. SINGULAR INTEGRAL EQUATIONS ALONG AN OPEN ARC WITH SOLUTIONS HAVING SINGULARITIES OF HIGHER ORDER

    Institute of Scientific and Technical Information of China (English)

    Zhong Shouguo

    2005-01-01

    In this paper, the difficulties on calculation in solving singular integral equations are overcome when the restriction of curve of integration to be a closed contour is cancelled. When the curve is an open arc and the solutions for singular integral equations possess singularities of higher order, the solution and the solvable condition for characteristic equations as well as the generalized Noether theorem for complete equations are given.

  3. Existence and Numerical Solution of the Volterra Fractional Integral Equations of the Second Kind

    Directory of Open Access Journals (Sweden)

    Abdon Atangana

    2013-01-01

    Full Text Available This work presents the possible generalization of the Volterra integral equation second kind to the concept of fractional integral. Using the Picard method, we present the existence and the uniqueness of the solution of the generalized integral equation. The numerical solution is obtained via the Simpson 3/8 rule method. The convergence of this scheme is presented together with numerical results.

  4. Biomedical nanotechnology.

    Science.gov (United States)

    Hurst, Sarah J

    2011-01-01

    This chapter summarizes the roles of nanomaterials in biomedical applications, focusing on those highlighted in this volume. A brief history of nanoscience and technology and a general introduction to the field are presented. Then, the chemical and physical properties of nanostructures that make them ideal for use in biomedical applications are highlighted. Examples of common applications, including sensing, imaging, and therapeutics, are given. Finally, the challenges associated with translating this field from the research laboratory to the clinic setting, in terms of the larger societal implications, are discussed.

  5. Structural and magnetic properties of cobalt-doped iron oxide nanoparticles prepared by solution combustion method for biomedical applications.

    Science.gov (United States)

    Venkatesan, Kaliyamoorthy; Rajan Babu, Dhanakotti; Kavya Bai, Mane Prabhu; Supriya, Ravi; Vidya, Radhakrishnan; Madeswaran, Saminathan; Anandan, Pandurangan; Arivanandhan, Mukannan; Hayakawa, Yasuhiro

    2015-01-01

    Cobalt-doped iron oxide nanoparticles were prepared by solution combustion technique. The structural and magnetic properties of the prepared samples were also investigated. The average crystallite size of cobalt ferrite (CoFe2O4) magnetic nanoparticle was calculated using Scherrer equation, and it was found to be 16±5 nm. The particle size was measured by transmission electron microscope. This value was found to match with the crystallite size calculated by Scherrer equation corresponding to the prominent intensity peak (311) of X-ray diffraction. The high-resolution transmission electron microscope image shows clear lattice fringes and high crystallinity of cobalt ferrite magnetic nanoparticles. The synthesized magnetic nanoparticles exhibited the saturation magnetization value of 47 emu/g and coercivity of 947 Oe. The anti-microbial activity of cobalt ferrite nanoparticles showed better results as an anti-bacterial agent. The affinity constant was determined for the nanoparticles, and the cytotoxicity studies were conducted for the cobalt ferrite nanoparticles at different concentrations and the results are discussed.

  6. Structural and magnetic properties of cobalt-doped iron oxide nanoparticles prepared by solution combustion method for biomedical applications

    Science.gov (United States)

    Venkatesan, Kaliyamoorthy; Rajan Babu, Dhanakotti; Kavya Bai, Mane Prabhu; Supriya, Ravi; Vidya, Radhakrishnan; Madeswaran, Saminathan; Anandan, Pandurangan; Arivanandhan, Mukannan; Hayakawa, Yasuhiro

    2015-01-01

    Cobalt-doped iron oxide nanoparticles were prepared by solution combustion technique. The structural and magnetic properties of the prepared samples were also investigated. The average crystallite size of cobalt ferrite (CoFe2O4) magnetic nanoparticle was calculated using Scherrer equation, and it was found to be 16±5 nm. The particle size was measured by transmission electron microscope. This value was found to match with the crystallite size calculated by Scherrer equation corresponding to the prominent intensity peak (311) of X-ray diffraction. The high-resolution transmission electron microscope image shows clear lattice fringes and high crystallinity of cobalt ferrite magnetic nanoparticles. The synthesized magnetic nanoparticles exhibited the saturation magnetization value of 47 emu/g and coercivity of 947 Oe. The anti-microbial activity of cobalt ferrite nanoparticles showed better results as an anti-bacterial agent. The affinity constant was determined for the nanoparticles, and the cytotoxicity studies were conducted for the cobalt ferrite nanoparticles at different concentrations and the results are discussed. PMID:26491320

  7. The Theory of Biomedical Knowledge Integration (Ⅶ)——The Non-Euclid Macro-Micro Transform Law

    Institute of Scientific and Technical Information of China (English)

    Hanfei Bao

    2007-01-01

    This article continued to do the scholastic pursuits on some profound mechanisms in the life systems, which are believed to be related to the further development of Medical Informatics. It discussed at first the structural nature of things, then probed a principle which is a basis for both of the fractal theory and the wavelet analysis, being called the shape-constancy law of the basic constructors at the different scale levels. And the paper also ventured the equivalency between the shape of wave and matrix, thus presented a new concept "shaped-number", being expected to work in the operations of some bio-medical functions or shapes.

  8. Darboux transformation and exact solutions of the integrable Heisenberg ferromagnetic equation with self-consistent potentials

    Science.gov (United States)

    Yersultanova, Z. S.; Zhassybayeva, M.; Yesmakhanova, K.; Nugmanova, G.; Myrzakulov, R.

    2016-10-01

    Integrable Heisenberg ferromagnetic equations are an important subclass of integrable systems. The M-XCIX equation is one of a generalizations of the Heisenberg ferromagnetic equation and are integrable. In this paper, the Darboux transformation of the M-XCIX equation is constructed. Using the DT, a 1-soliton solution of the M-XCIX equation is presented.

  9. Wafer bonding solution to epitaxial graphene-silicon integration

    Science.gov (United States)

    Dong, Rui; Guo, Zelei; Palmer, James; Hu, Yike; Ruan, Ming; Hankinson, John; Kunc, Jan; Bhattacharya, Swapan K.; Berger, Claire; de Heer, Walt A.

    2014-03-01

    A new strategy for the integration of graphene electronics with silicon complementary metal-oxide-semiconductor (Si-CMOS) technology is demonstrated that requires neither graphene transfer nor patterning. Inspired by silicon-on-insulator and three-dimensional device hyper-integration techniques, a thin monocrystalline silicon layer ready for CMOS processing is bonded to epitaxial graphene (EG) on SiC. The parallel Si and graphene electronic platforms are interconnected by metal vias. In this method, EG is grown prior to bonding so that the process is compatible with EG high temperature growth and preserves graphene integrity and nano-structuring.

  10. The First-Integral Method and Abundant Explicit Exact Solutions to the Zakharov Equations

    Directory of Open Access Journals (Sweden)

    Yadong Shang

    2012-01-01

    Full Text Available This paper is concerned with the system of Zakharov equations which involves the interactions between Langmuir and ion-acoustic waves in plasma. Abundant explicit and exact solutions of the system of Zakharov equations are derived uniformly by using the first integral method. These exact solutions are include that of the solitary wave solutions of bell-type for n and E, the solitary wave solutions of kink-type for E and bell-type for n, the singular traveling wave solutions, periodic wave solutions of triangle functions, Jacobi elliptic function doubly periodic solutions, and Weierstrass elliptic function doubly periodic wave solutions. The results obtained confirm that the first integral method is an efficient technique for analytic treatment of a wide variety of nonlinear systems of partial differential equations.

  11. Biomedical Engineering

    CERN Document Server

    Suh, Sang C; Tanik, Murat M

    2011-01-01

    Biomedical Engineering: Health Care Systems, Technology and Techniques is an edited volume with contributions from world experts. It provides readers with unique contributions related to current research and future healthcare systems. Practitioners and researchers focused on computer science, bioinformatics, engineering and medicine will find this book a valuable reference.

  12. Biomedical Libraries

    Science.gov (United States)

    Pizer, Irwin H.

    1978-01-01

    Biomedical libraries are discussed as a distinct and specialized group of special libraries and their unique services and user interactions are described. The move toward professional standards, as evidenced by the Medical Library Association's new certification program, and the current state of development for a new section of IFLA established…

  13. Approaching the BFKL pomeron via integrable classical solutions

    Energy Technology Data Exchange (ETDEWEB)

    Janik, Romuald A.; Laskoś-Grabowski, Paweł [Institute of Physics, Jagiellonian University,ul. Reymonta 4, 30-059 Kraków (Poland)

    2014-01-16

    We identify classical string solutions which directly give the classical part of the strong coupling pomeron intercept. The relevant solution is a close cousin of the GKP folded string, which is not surprising given the known relation with twist-2 operators. Our methods are applicable, however, also for nonzero conformal spin where we do not have a clear link with anomalous dimensions of a concrete class of operators. We analyze the BFKL folded string from the algebraic curve perspective and investigate its possible particle content.

  14. Supporting Integrated Healthcare Solutions with Patients in Home Settings

    DEFF Research Database (Denmark)

    Jørgensen, Daniel Bjerring

    2016-01-01

    : The state-of-the-art of how national ICT infrastructures are designed has been identified and problems of that approach discussed. The foundation for a patient centric home/local infrastructure, to integrate data using applications and data providing applications e.g. medical devices, has been developed...

  15. Research enrichment: evaluation of structured research in the curriculum for dental medicine students as part of the vertical and horizontal integration of biomedical training and discovery

    Directory of Open Access Journals (Sweden)

    Stewart Tanis

    2008-02-01

    Full Text Available Abstract Background Research programs within medical and dental schools are important vehicles for biomedical and clinical discovery, serving as effective teaching and learning tools by providing situations in which predoctoral students develop problem-solving and critical-thinking skills. Although research programs at many medical and dental schools are well-established, they may not be well integrated into the predoctoral curriculum to effectively support the learning objectives for their students. Methods A series of structured seminars, incorporating faculty research, was designed for first-year dental students at the University of Nevada, Las Vegas, School of Dental Medicine to reinforce and support the concepts and skills taught in concurrent courses. A structured research enrichment period was also created to facilitate student engagement in active research using faculty and student curricular release time. Course evaluations and surveys were administered to gauge student perceptions of the curricular integration of research, the impact of these seminars on recruitment to the research program, and overall levels of student satisfaction with research enrichment. Results The analysis of course surveys revealed that students perceived the research-containing seminars effectively illustrated concepts, were logically sequenced, and were well-integrated into their curriculum. In addition, analysis of surveys revealed that the Integration Seminar courses motivated students to engage in research enrichment. Finally, this analysis provided evidence that students were very satisfied with their overall learning experience during research enrichment. Conclusion Curricular integration is one method of improving the teaching and learning of complicated and inter-related concepts, providing an opportunity to incorporate research training and objectives into traditionally separate didactic courses. Despite the benefits of curricular integration, finding

  16. An Accurate Heading Solution using MEMS-based Gyroscope and Magnetometer Integrated System (Preliminary Results)

    Science.gov (United States)

    El-Diasty, M.

    2014-11-01

    An accurate heading solution is required for many applications and it can be achieved by high grade (high cost) gyroscopes (gyros) which may not be suitable for such applications. Micro-Electro Mechanical Systems-based (MEMS) is an emerging technology, which has the potential of providing heading solution using a low cost MEMS-based gyro. However, MEMS-gyro-based heading solution drifts significantly over time. The heading solution can also be estimated using MEMS-based magnetometer by measuring the horizontal components of the Earth magnetic field. The MEMS-magnetometer-based heading solution does not drift over time, but are contaminated by high level of noise and may be disturbed by the presence of magnetic field sources such as metal objects. This paper proposed an accurate heading estimation procedure based on the integration of MEMS-based gyro and magnetometer measurements that correct gyro and magnetometer measurements where gyro angular rates of changes are estimated using magnetometer measurements and then integrated with the measured gyro angular rates of changes with a robust filter to estimate the heading. The proposed integration solution is implemented using two data sets; one was conducted in static mode without magnetic disturbances and the second was conducted in kinematic mode with magnetic disturbances. The results showed that the proposed integrated heading solution provides accurate, smoothed and undisturbed solution when compared with magnetometerbased and gyro-based heading solutions.

  17. Biomedical Materials

    Institute of Scientific and Technical Information of China (English)

    CHANG Jiang; ZHOU Yanling

    2011-01-01

    @@ Biomedical materials, biomaterials for short, is regarded as "any substance or combination of substances, synthetic or natural in origin, which can be used for any period of time, as a whole or as part of a system which treats, augments, or replaces any tissue, organ or function of the body" (Vonrecum & Laberge, 1995).Biomaterials can save lives, relieve suffering and enhance the quality of life for human being.

  18. Business Process Management Integration Solution in Financial Sector

    Directory of Open Access Journals (Sweden)

    2009-01-01

    Full Text Available It is vital for financial services companies to ensure the rapid implementation of new processes to meet speed-to-market, service quality and compliance requirements. This has to be done against a background of increased complexity. An integrated approach to business processes allows products, processes, systems, data and the applications that underpin them to evolve quickly. Whether it’s providing a loan, setting up an insurance policy, or executing an investment instruction, optimizing the sale-to-fulfillment process will always win new business, cement customer loyalty, and reduce costs. Lack of integration across lending, payments and trading, on the other hand, simply presents competitors who are more efficient with a huge profit opportunity.

  19. Existence and uniqueness of solutions for nonlinear hyperbolic fractional differential equation with integral boundary conditions

    OpenAIRE

    Brahim Tellab; Kamel Haouam

    2016-01-01

    In this paper, we investigate the existence and uniqueness of solutions for second order nonlinear fractional differential equation with integral boundary conditions. Our result is an application of the Banach contraction principle and the Krasnoselskii fixed point theorem.

  20. MULTIPLE POSITIVE SOLUTIONS TO A SYSTEM OF NONLINEAR HAMMERSTEIN TYPE INTEGRAL EQUATIONS

    Institute of Scientific and Technical Information of China (English)

    Wang Feng; Zhang Fang; Liu Chunhan

    2009-01-01

    In this paper, we use cone theory and a new method of computation of fixed point index to study a system of nonlinear Hammerstein type integral equations, and the existence of multiple positive solutions to the system is discussed.

  1. Multiple Positive Solutions for Some Neutral Integral Equatious Modeling Infectious Disease

    Institute of Scientific and Technical Information of China (English)

    ZHAOHua-xiang; SUNXing-wang

    2003-01-01

    By using fixed point index theory of cone mapping and extension method,this paper discusses the existence of multiple positive solution of nonlinear neutral integral equatious modeling infectious dis-ease.

  2. Nontrivial Solution of Fractional Differential System Involving Riemann-Stieltjes Integral Condition

    Directory of Open Access Journals (Sweden)

    Ge-Feng Yang

    2012-01-01

    differential system involving the Riemann-Stieltjes integral condition, by using the Leray-Schauder nonlinear alternative and the Banach contraction mapping principle, some sufficient conditions of the existence and uniqueness of a nontrivial solution of a system are obtained.

  3. An Integrated Solution for Performing Thermo-fluid Conjugate Analysis

    Science.gov (United States)

    Kornberg, Oren

    2009-01-01

    A method has been developed which integrates a fluid flow analyzer and a thermal analyzer to produce both steady state and transient results of 1-D, 2-D, and 3-D analysis models. The Generalized Fluid System Simulation Program (GFSSP) is a one dimensional, general purpose fluid analysis code which computes pressures and flow distributions in complex fluid networks. The MSC Systems Improved Numerical Differencing Analyzer (MSC.SINDA) is a one dimensional general purpose thermal analyzer that solves network representations of thermal systems. Both GFSSP and MSC.SINDA have graphical user interfaces which are used to build the respective model and prepare it for analysis. The SINDA/GFSSP Conjugate Integrator (SGCI) is a formbase graphical integration program used to set input parameters for the conjugate analyses and run the models. The contents of this paper describes SGCI and its thermo-fluids conjugate analysis techniques and capabilities by presenting results from some example models including the cryogenic chill down of a copper pipe, a bar between two walls in a fluid stream, and a solid plate creating a phase change in a flowing fluid.

  4. GLOBAL SOLUTIONS OF SYSTEMS OF NONLINEAR IMPULSIVE VOLTERRA INTEGRAL EQUATIONS IN BANACH SPACES

    Institute of Scientific and Technical Information of China (English)

    陈芳启; 陈予恕

    2001-01-01

    The existence of solutions for systems of nonlinear impulsive Volterra integral equations on the infinite interval R+ with an infinite number of moments of impulse effect in Banach spaces is studied. Some existence theorems of extremal solutions are obtained,which extend the related results for this class of equations on a finite interval with a finite number of moments of impulse effect. The results are demonstrated by means of an example of an infinite systems for impulsive integral equations.

  5. The Exact Traveling Wave Solutions to Two Integrable KdV6 Equations

    Institute of Scientific and Technical Information of China (English)

    Jibin LI; Yi ZHANG

    2012-01-01

    The exact explicit traveling solutions to the two completely integrable sixthorder nonlinear equations KdV6 are given by using the method of dynamical systems and Cosgrove's work.It is proved that these traveling wave solutions correspond to some orbits in the 4-dimensional phase space of two 4-dimensional dynamical systems.These orbits lie in the intersection of two level sets defined by two first integrals.

  6. Integrable, molecular-type solutions of the extended Skyrme-Faddeev model

    CERN Document Server

    Sawado, Nobuyuki

    2013-01-01

    We construct molecular type vortex solutions in the integrable sector of the extended Skyrme-Faddeev (ESF) model.The solutions are a holomorphic type which satisfies the zero curvature condition.For some constrained values of the coupling constants, special vortex solutions exist.For other values, special forms of the potential are employed for the stability of the molecular type solution.The solutions satisfy the zero curvature condition, and then they necessarily have an infinite number of conserved current. We numerically check their existence in terms of the simulated annealing method.

  7. Comprehensive Solutions for Integration of Solar Resources into Grid Operations

    Energy Technology Data Exchange (ETDEWEB)

    Pennock, Kenneth [AWS Truepower, LLC, Albany, NY (United States); Makarov, Yuri V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Rajagopal, Sankaran [Siemens Energy, Erlangen (Germany); Loutan, Clyde [California Independent System Operator; Etingov, Pavel V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Miller, Laurie E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Lu, Bo [Siemens Energy, Erlangen (Germany); Mansingh, Ashmin [Siemens Energy, Erlangen (Germany); Zack, John [MESO, Inc., Raleigh, NC (United States); Sherick, Robert [Southern California Edison, Rosemead, CA (United States); Romo, Abraham [Southern California Edison; Habibi-Ashrafi, Farrokh [Southern California Edison; Johnson, Raymond [Southern California Edison

    2016-01-14

    The need for proactive closed-loop integration of uncertainty information into system operations and probability-based controls is widely recognized, but rarely implemented in system operations. Proactive integration for this project means that the information concerning expected uncertainty ranges for net load and balancing requirements, including required balancing capacity, ramping and ramp duration characteristics, will be fed back into the generation commitment and dispatch algorithms to modify their performance so that potential shortages of these characteristics can be prevented. This basic, yet important, premise is the motivating factor for this project. The achieved project goal is to demonstrate the benefit of such a system. The project quantifies future uncertainties, predicts additional system balancing needs including the prediction intervals for capacity and ramping requirements of future dispatch intervals, evaluates the impacts of uncertainties on transmission including the risk of overloads and voltage problems, and explores opportunities for intra-hour generation adjustments helping to provide more flexibility for system operators. The resulting benefits culminate in more reliable grid operation in the face of increased system uncertainty and variability caused by solar power. The project identifies that solar power does not require special separate penetration level restrictions or penalization for its intermittency. Ultimately, the collective consideration of all sources of intermittency distributed over a wide area unified with the comprehensive evaluation of various elements of balancing process, i.e. capacity, ramping, and energy requirements, help system operators more robustly and effectively balance generation against load and interchange. This project showed that doing so can facilitate more solar and other renewable resources on the grid without compromising reliability and control performance. Efforts during the project included

  8. STABILITY AND BOUNDEDNESS OF SOLUTIONS OF VOLTERRA INTEGRAL DIFFERENTIAL EQUATIONS WITH INFINITE DELAY

    Institute of Scientific and Technical Information of China (English)

    Dishen; Jiabu

    2006-01-01

    This paper studies the stability and boundedness of the solutions of Volterra integral differential equations with infinite delay in the phase space (Ch, |·|h), the h-uniform stability, h-uniformly asymptotic stability and h-boundedness of solutions are obtained.

  9. Positive Solutions for Nonlinear Fractional Differential Equations with Boundary Conditions Involving Riemann-Stieltjes Integrals

    Directory of Open Access Journals (Sweden)

    Jiqiang Jiang

    2012-01-01

    Full Text Available We consider the existence of positive solutions for a class of nonlinear integral boundary value problems for fractional differential equations. By using some fixed point theorems, the existence and multiplicity results of positive solutions are obtained. The results obtained in this paper improve and generalize some well-known results.

  10. Positive Solutions of a Nonlinear Fourth-order Integral Boundary Value Problem

    Directory of Open Access Journals (Sweden)

    Benaicha Slimane

    2016-07-01

    Full Text Available In this paper, the existence of positive solutions for a nonlinear fourth-order two-point boundary value problem with integral condition is investigated. By using Krasnoselskii’s fixed point theorem on cones, sufficient conditions for the existence of at least one positive solutions are obtained.

  11. Continuous solutions for fractional integral inclusion in locally convex topological space

    Institute of Scientific and Technical Information of China (English)

    Rabha W. Ibrahim

    2009-01-01

    The existence of continuous solutions for fractional integral inclusion via its singlevalued problem and fixed point theorem for set-valued function in locally convex topological spaces is discussed. The proof of the single-valued problem will be based on the Leray- Schauder fixed point theorem. Moreover, the controllability of this solution is studied.

  12. 75 FR 11939 - Integrated Silicon Solution, Inc. (ISSI); San Jose, CA; Notice of Termination of Investigation

    Science.gov (United States)

    2010-03-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Integrated Silicon Solution, Inc. (ISSI); San Jose, CA; Notice of... Silicon Solution, Inc., San Jose, California. The petitioner has requested that the petition be...

  13. Conditionality of inverse solutions to discretised integral equations in geoid modelling from local gravity data

    NARCIS (Netherlands)

    Tenzer, R.; Novák, P.

    2008-01-01

    The eigenvalue decomposition technique is used for analysis of conditionality of two alternative solutions for a determination of the geoid from local gravity data. The first solution is based on the standard two-step approach utilising the inverse of the Abel-Poisson integral equation (downward

  14. New solutions for two integrable cases of a generalized fifth-order nonlinear equation

    Science.gov (United States)

    Wazwaz, Abdul-Majid

    2015-05-01

    Multiple-complexiton solutions for a new generalized fifth-order nonlinear integrable equation are constructed with the help of the Hirota's method and the simplified Hirota's method. By extending the real parameters into complex parameters, nonsingular complexiton solutions are obtained for two specific coefficients of the new generalized equation.

  15. Wavelet-based integral representation for solutions of the wave equation

    Energy Technology Data Exchange (ETDEWEB)

    Perel, Maria V; Sidorenko, Mikhail S [Department of Mathematical Physics, Physics Faculty, St Petersburg University, Ulyanovskaya 1-1, Petrodvorets, St Petersburg 198904 (Russian Federation)], E-mail: perel@mph.phys.spbu.ru, E-mail: M-Sidorenko@yandex.ru

    2009-09-18

    An integral representation of solutions of the wave equation as a superposition of other solutions of this equation is built. The solutions from a wide class can be used as building blocks for the representation. Considerations are based on mathematical techniques of continuous wavelet analysis. The formulae obtained are justified from the point of view of distribution theory. A comparison of the results with those by G Kaiser is carried out. Methods of obtaining physical wavelets are discussed.

  16. Analytical solution of two-phase spherical Stefan problem by heat polynomials and integral error functions

    Science.gov (United States)

    Kharin, Stanislav N.; Sarsengeldin, Merey M.; Nouri, Hassan

    2016-08-01

    On the base of the Holm model, we represent two phase spherical Stefan problem and its analytical solution, which can serve as a mathematical model for diverse thermo-physical phenomena in electrical contacts. Suggested solution is obtained from integral error function and its properties which are represented in the form of series whose coefficients have to be determined. Convergence of solution series is proved.

  17. Integration of Finite Element Method with Runge – Kuta Solution Algorithm

    Directory of Open Access Journals (Sweden)

    Olawale Simon

    2017-05-01

    Full Text Available Runge – Kuta (RK method is reasonably simple and robust for numerical solution of differential equations but it requires an intelligent adaptive step-size routine; to achieve this, there is need to develop a good logical computer code. This study develops a finite element code in Java using Runge-Kuta method as a solution algorithm to predict dynamic time response of structural beam under impulse load. The solution obtained using direct integration and the present work is comparable.

  18. Construction of N-soliton solutions for a new integrable equation by Darboux transformation

    Science.gov (United States)

    Bai, Shuting; Zhaqilao

    2016-10-01

    In this paper, the relationship between a new integrable equation and well-known KdV equation is established by a set of transformation. With the help of Darboux transformation of KdV equation and the set of transformation, parametric representations of multi-soliton solutions for the new integrable equation are obtained, and their figures are plotted.

  19. ESTIMATION METHOD FOR SOLUTIONS TO GENERAL LINEAR SYSTEM OF VOLTERRAINTEGRAL INEQUALITIES INVOLVING ITERATED INTEGRAL FUNCTIONALS

    Institute of Scientific and Technical Information of China (English)

    MA Qinghua; YANG Enhao

    2000-01-01

    An estimation method for solutions to the general linear system of Volterratype integral inequalities containing several iterated integral functionals is obtained. This method is based on a result proved by the present second author in Journ. Math. Anal. Appl.(1984). A certain two-dimensional system of nonlinear ordinary differential equations is also discussed to demonstrate the usefulness of our method.

  20. Singular Integral Equations with Cosecant Kernel in Solutions with Singularities of High Order

    Institute of Scientific and Technical Information of China (English)

    HAN Hui-li; DU Jin-yuan

    2005-01-01

    We have discussed and solved the boundary value problem with period 2aπ and the singular integral equation with kernel csc t-t0/a in solution having singularities of high order, where the smooth contour of integration is in the strip 0<Rez<aπ.

  1. Path Integral and Solutions of the Constraint Equations The Case of Reducible Gauge Theories

    CERN Document Server

    Ferraro, R; Puchin, M

    1994-01-01

    It is shown that the BRST path integral for reducible gauge theories, with appropriate boundary conditions on the ghosts, is a solution of the constraint equations. This is done by relating the BRST path integral to the kernel of the evolution operator projected on the physical subspace.

  2. Exploring and linking biomedical resources through multidimensional semantic spaces

    National Research Council Canada - National Science Library

    Berlanga, Rafael; Jiménez-Ruiz, Ernesto; Nebot, Victoria

    .... The availability of comprehensive knowledge resources such as biomedical ontologies and integrated thesauri greatly facilitates this integration effort by means of semantic annotation, which allows...

  3. Integral Solution of 3D Electric Field of a Disconnector

    Directory of Open Access Journals (Sweden)

    Pavel Karban

    2008-01-01

    Full Text Available The disconnectors belong to elements widely used in electrical power engineering and apparatus technology for disconnecting various electric circuits. Usually they work without voltage (the circuit is first switched off by a circuit breaker. Nevertheless, in a fault regime the contacts of the disconnector may carry the full voltage, which may result in the electric arc between them at the moment when the movable contact approaches to the fixed one. In order to estimate this moment it is necessary to know the time evolution of the electric field in the domain between both contacts. This problem is solved in 3D (in somewhat simplified geometry by the integral technique. The theoretical analysis is supplemented with an illustrative example whose results are discussed.

  4. An integrated engineering solution in treating tailings pond water (TPW)

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Z. [Alberta Univ., Edmonton, AB (Canada)

    2010-07-01

    This presentation described the progress that has been made in the treatment of tailings pond water (TPW). Several treatment technologies were examined for their potential use. Any valid treatment methods must be technically practicable and economically feasible in treating TPW. An integrated TPW treatment process was proposed in this paper after reviewing recent published literature related to TPW treatment. The process was proposed based on knowledge and experience gained from municipal and other industrial water and wastewater treatment operations. This engineered treatment process consists of bioadsorption, bioflocculation, suspended sludge blanket filtration, clarification, ozonation, and coke assisted hybrid biodegradation. The proposed treatment process was aiming at environmental release and/or further reuse of the treated TPW. This proposed treatment process features the reuse of 2 waste materials in order to enhance the treatment efficiency, to increase financial feasibility, and to maximize environmental benefits of the treatment. tabs., figs.

  5. SOLUTION OF MULTIPLE CURVED RIGID LINE AND ANTIPLANE CIRCULAR INCLUSION PROBLEM BY WEAKLY SINGULAR INTEGRAL EQUATION

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Interaction between multiple curved rigid line and circular inclusion in antiplane loading condition was considered. Two kinds of elementary solutions corresponding to a concentrated force applying at inclusion and matrix material respectively were presented. Utilizing the elementary solutions and taking density function of traction difference along curved rigid line, a group of weakly singular integral equations with log kernels can be obtained. After the numerical solution of the integral equations, the discrete values of density functions of traction difference are obtainable. So stress singularity coefficients at rigid line tips can be calculated, and several numerical examples are given.

  6. Existence of Wave Front Solutions of an Integral Differential Equation in Nonlinear Nonlocal Neuronal Network

    Directory of Open Access Journals (Sweden)

    Lijun Zhang

    2014-01-01

    Full Text Available An integral-differential model equation arising from neuronal networks with very general kernel functions is considered in this paper. The kernel functions we study here include pure excitations, lateral inhibition, lateral excitations, and more general synaptic couplings (e.g., oscillating kernel functions. The main goal of this paper is to prove the existence and uniqueness of the traveling wave front solutions. The main idea we apply here is to reduce the nonlinear integral-differential equation into a solvable differential equation and test whether the solution we get is really a wave front solution of the model equation.

  7. An Integrated Software-based Solution for Modular and Self-independent Networked Robot

    CERN Document Server

    Firmansyah, I; Hermanto, B; Handoko, L T

    2008-01-01

    An integrated software-based solution for a modular and self-independent networked robot is introduced. The wirelessly operatable robot has been developed mainly for autonomous monitoring works with full control over web. The integrated software solution covers three components : a) the digital signal processing unit for data retrieval and monitoring system; b) the externally executable codes for control system; and c) the web programming for interfacing the end-users with the robot. It is argued that this integrated software-based approach is crucial to realize a flexible, modular and low development cost mobile monitoring apparatus.

  8. DIRECT MATHEMATICAL SOLUTIONS FOR THE GAMMA-RAY DETECTORS GEOMETRICAL AND TOTAL EFFICIENCIES INTEGRABLE FORMULAE

    Directory of Open Access Journals (Sweden)

    MAHMOUD I. ABBAS

    2017-03-01

    Full Text Available A new mathematical solution for the geometrical and total efficiencies integrable equations of cylindrical and spherical gamma-ray detectors is proposed. The efficiencies integrable equations are based on the accurate analytical computation of the photon path length traverses within the detector active medium, and the geometrical solid angle, Ω, subtended by the source to the detector at the point of entrance. The comparison between the efficiencies calculated values by the use of both, the integrable and direct solution formulae, showing very good agreement.

  9. SAS Enterprise Data Integration Server - A Complete Solution Designed To Meet the Full Spectrum of Enterprise Data Integration Needs

    Directory of Open Access Journals (Sweden)

    Silvia BOLOHAN

    2012-05-01

    Full Text Available This paper is about why is Data Integration important for organisations around the world. Organizations struggle daily with the challenges of large distributed data volumes, inconsistently defined data across disparate systems and the high expectations of data consumers who depend on information to be correct, complete and available when they need it. SAS Enterprise Data Integration Server provides a comprehensive solution that enables organizations to solve these challenges in a timely, cost-effective manner with the ability to efficiently manage data integration projects on an enterprise scale, increasing overall productivity and reducing the total cost of ownership.

  10. On the maximal cut of Feynman integrals and the solution of their differential equations

    CERN Document Server

    Primo, Amedeo

    2016-01-01

    The standard procedure for computing scalar multi-loop Feynman integrals consists in reducing them to a basis of so-called master integrals, derive differential equations in the external invariants satisfied by the latter and, finally, try to solve them as a Laurent series in $\\epsilon = (4-d)/2$, where $d$ are the space-time dimensions. The differential equations are, in general, coupled and can be solved using Euler's variation of constants, provided that a set of homogeneous solutions is known. Given an arbitrary differential equation of order higher than one, there exist no general method for finding its homogeneous solutions. In this paper we show that the maximal cut of the integrals under consideration provides one set of homogeneous solutions, simplifying substantially the solution of the differential equations.

  11. On the maximal cut of Feynman integrals and the solution of their differential equations

    Directory of Open Access Journals (Sweden)

    Amedeo Primo

    2017-03-01

    Full Text Available The standard procedure for computing scalar multi-loop Feynman integrals consists in reducing them to a basis of so-called master integrals, derive differential equations in the external invariants satisfied by the latter and, finally, try to solve them as a Laurent series in ϵ=(4−d/2, where d are the space–time dimensions. The differential equations are, in general, coupled and can be solved using Euler's variation of constants, provided that a set of homogeneous solutions is known. Given an arbitrary differential equation of order higher than one, there exists no general method for finding its homogeneous solutions. In this paper we show that the maximal cut of the integrals under consideration provides one set of homogeneous solutions, simplifying substantially the solution of the differential equations.

  12. Matrix integral solutions to the discrete KP hierarchy and its Pfaffianized version

    Science.gov (United States)

    Lafortune, Stéphane; Li, Chun-Xia

    2016-11-01

    Matrix integrals used in random matrix theory for the study of eigenvalues of Hermitian ensembles have been shown to provide τ-functions for several hierarchies of integrable equations. In this article, we extend this relation by showing that such integrals can also provide τ-functions for the discrete KP hierarchy and a coupled version of the same hierarchy obtained through the process of Pfaffianization. To do so, we consider the first equation of the discrete KP hierarchy, the Hirota-Miwa equation. We write the Wronskian determinant solutions to the Hirota-Miwa equation and consider a particular form of matrix integrals, which we show is an example of those Wronskian solutions. The argument is then generalized to the whole hierarchy. A similar strategy is used for the Pfaffianized version of the hierarchy except that in that case, the solutions are written in terms of Pfaffians rather than determinants.

  13. Painlevé Integrability and New Exact Solutions of the (4 + 1-Dimensional Fokas Equation

    Directory of Open Access Journals (Sweden)

    Sheng Zhang

    2015-01-01

    Full Text Available The Painlevé integrability of the (4+1-dimensional Fokas equation is verified by the WTC method of Painlevé analysis combined with a new and more general transformation. By virtue of the truncated Painlevé expansion, two new exact solutions with arbitrary differentiable functions are obtained. Thanks to the arbitrariness of the included functions, the obtained exact solutions not only possess rich spatial structures but also help to bring about two-wave solutions and three-wave solutions. It is shown that the transformation adopted in this work plays a key role in testing the Painlevé integrability and constructing the exact solutions of the Fokas equation.

  14. An interative solution of an integral equation for radiative transfer by using variational technique

    Science.gov (United States)

    Yoshikawa, K. K.

    1973-01-01

    An effective iterative technique is introduced to solve a nonlinear integral equation frequently associated with radiative transfer problems. The problem is formulated in such a way that each step of an iterative sequence requires the solution of a linear integral equation. The advantage of a previously introduced variational technique which utilizes a stepwise constant trial function is exploited to cope with the nonlinear problem. The method is simple and straightforward. Rapid convergence is obtained by employing a linear interpolation of the iterative solutions. Using absorption coefficients of the Milne-Eddington type, which are applicable to some planetary atmospheric radiation problems. Solutions are found in terms of temperature and radiative flux. These solutions are presented numerically and show excellent agreement with other numerical solutions.

  15. A path-independent integral for the characterization of solute concentration and flux at biofilm detachments

    Science.gov (United States)

    Moran, B.; Kulkarni, S.S.; Reeves, H.W.

    2007-01-01

    A path-independent (conservation) integral is developed for the characterization of solute concentration and flux in a biofilm in the vicinity of a detachment or other flux limiting boundary condition. Steady state conditions of solute diffusion are considered and biofilm kinetics are described by an uptake term which can be expressed in terms of a potential (Michaelis-Menten kinetics). An asymptotic solution for solute concentration at the tip of the detachment is obtained and shown to be analogous to that of antiplane crack problems in linear elasticity. It is shown that the amplitude of the asymptotic solution can be calculated by evaluating a path-independent integral. The special case of a semi-infinite detachment in an infinite strip is considered and the amplitude of the asymptotic field is related to the boundary conditions and problem parameters in closed form for zeroth and first order kinetics and numerically for Michaelis-Menten kinetics. ?? Springer Science+Business Media, Inc. 2007.

  16. Integrating matrix solution of the hybrid state vector equations for beam vibration

    Science.gov (United States)

    Lehman, L. L.

    1982-01-01

    A simple, versatile, and efficient computational technique has been developed for dynamic analysis of linear elastic beam and rod type of structures. Moreover, the method provides a rather general solution approach for two-point boundary value problems that are described by a single independent spatial variable. For structural problems, the method is implemented by a mixed state vector formulation of the differential equations, combined with an integrating matrix solution procedure. Highly accurate solutions are easily achieved with this approach. Example solutions are given for beam vibration problems including discontinuous stiffness and mass parameters, elastic restraint boundary conditions, concentrated inertia loading, and rigid body modes

  17. Pentaho Kettle Solutions Building Open Source ETL Solutions with Pentaho Data Integration

    CERN Document Server

    Casters, Matt; van Dongen, Jos

    2010-01-01

    A complete guide to Pentaho Kettle, the Pentaho Data lntegration toolset for ETL. This practical book is a complete guide to installing, configuring, and managing Pentaho Kettle. If you're a database administrator or developer, you'll first get up to speed on Kettle basics and how to apply Kettle to create ETL solutions—before progressing to specialized concepts such as clustering, extensibility, and data vault models. Learn how to design and build every phase of an ETL solution.: Shows developers and database administrators how to use the open-source Pentaho Kettle for enterprise-level ETL pr

  18. Greenhouse Gas Emissions Reporting through Integrated Business Solutions

    Science.gov (United States)

    Smith, D.

    2010-12-01

    recent economic downturn to supporting the development and manufacture of clean tech products and related services such as energy assessments and building retrofits. Whether a business has a mandatory requirement to act on a carbon management reduction or is volunteering to implement energy efficiencies initiatives, it is imperative that a solution is found. This presentation illustrates how a business can focus on sustainability; improve organizations’ profitability; generate eco-aware initiatives; and improve understanding of corporate social responsibility and the legal requirements and consumer expectations.

  19. New Exact Solutions of Some Nonlinear Systems of Partial Differential Equations Using the First Integral Method

    Directory of Open Access Journals (Sweden)

    Shoukry Ibrahim Atia El-Ganaini

    2013-01-01

    Full Text Available The first integral method introduced by Feng is adopted for solving some important nonlinear systems of partial differential equations, including classical Drinfel'd-Sokolov-Wilson system (DSWE, (2 + 1-dimensional Davey-Stewartson system, and generalized Hirota-Satsuma coupled KdV system. This method provides polynomial first integrals for autonomous planar systems. Through the established first integrals, exact traveling wave solutions are formally derived in a concise manner. This method can also be applied to nonintegrable equations as well as integrable ones.

  20. An integrable, web-based solution for easy assessment of video-recorded performances

    DEFF Research Database (Denmark)

    Subhi, Yousif; Todsen, Tobias; Konge, Lars

    2014-01-01

    , and access to this information should be restricted to select personnel. A local software solution may also ease the need for customization to local needs and integration into existing user databases or project management software. We developed an integrable web-based solution for easy assessment of video......Assessment of clinical competencies by direct observation is problematic for two main reasons the identity of the examinee influences the assessment scores, and direct observation demands experts at the exact location and the exact time. Recording the performance can overcome these problems......; however, managing video recordings and assessment sheets is troublesome and may lead to missing or incorrect data. Currently, no existing software solution can provide a local solution for the management of videos and assessments but this is necessary as assessment scores are confidential information...

  1. Biomedical accelerator mass spectrometry

    Science.gov (United States)

    Freeman, Stewart P. H. T.; Vogel, John S.

    1995-05-01

    Ultrasensitive SIMS with accelerator based spectrometers has recently begun to be applied to biomedical problems. Certain very long-lived radioisotopes of very low natural abundances can be used to trace metabolism at environmental dose levels ( [greater-or-equal, slanted] z mol in mg samples). 14C in particular can be employed to label a myriad of compounds. Competing technologies typically require super environmental doses that can perturb the system under investigation, followed by uncertain extrapolation to the low dose regime. 41Ca and 26Al are also used as elemental tracers. Given the sensitivity of the accelerator method, care must be taken to avoid contamination of the mass spectrometer and the apparatus employed in prior sample handling including chemical separation. This infant field comprises the efforts of a dozen accelerator laboratories. The Center for Accelerator Mass Spectrometry has been particularly active. In addition to collaborating with groups further afield, we are researching the kinematics and binding of genotoxins in-house, and we support innovative uses of our capability in the disciplines of chemistry, pharmacology, nutrition and physiology within the University of California. The field can be expected to grow further given the numerous potential applications and the efforts of several groups and companies to integrate more the accelerator technology into biomedical research programs; the development of miniaturized accelerator systems and ion sources capable of interfacing to conventional HPLC and GMC, etc. apparatus for complementary chemical analysis is anticipated for biomedical laboratories.

  2. S-asymptotically -periodic Solutions of R-L Fractional Derivative-Integral Equation

    Institute of Scientific and Technical Information of China (English)

    WANG Bing

    2015-01-01

    The aim of this paper is to study the S-asymptotically ω-periodic solutions of R-L fractional derivative-integral equation:is a linear densely defined operator of sectorial type on a completed Banach space X, f is a continuous function satisfying a suitable Lipschitz type condition. We will use the contraction mapping theory to prove problem (1) and (2) has a unique S-asymptotically ω-periodic solution if the function f satisfies Lipshcitz condition.

  3. High Order Numerical Solution of Integral Transport Equation in Slab Geometry

    Institute of Scientific and Technical Information of China (English)

    沈智军; 袁光伟; 沈隆钧

    2002-01-01

    @@ There are some common numerical methods for solving neutron transport equation, which including the well-known discrete ordinates method, PN approximation and integral transport methods[1]. There exists certain singularities in the solution of transport equation near the boundary and interface[2]. It gives rise to the difficulty in the construction of high order accurate numerical methods. The numerical solution obtained by now can not attain the second order convergent accuracy[3,4].

  4. Approximate Solution of Urysohn Integral Equations Using the Adomian Decomposition Method

    Directory of Open Access Journals (Sweden)

    Randhir Singh

    2014-01-01

    Full Text Available We apply Adomian decomposition method (ADM for obtaining approximate series solution of Urysohn integral equations. The ADM provides a direct recursive scheme for solving such problems approximately. The approximations of the solution are obtained in the form of series with easily calculable components. Furthermore, we also discuss the convergence and error analysis of the ADM. Moreover, three numerical examples are included to demonstrate the accuracy and applicability of the method.

  5. Local-instantaneous filtering in the integral transform solution of nonlinear diffusion problems

    Science.gov (United States)

    Macêdo, E. N.; Cotta, R. M.; Orlande, H. R. B.

    A novel filtering strategy is proposed to be utilized in conjunction with the Generalized Integral Transform Technique (GITT), in the solution of nonlinear diffusion problems. The aim is to optimize convergence enhancement, yielding computationally efficient eigenfunction expansions. The proposed filters include space and time dependence, extracted from linearized versions of the original partial differential system. The scheme automatically updates the filter along the time integration march, as the required truncation orders for the user requested accuracy begin to exceed a prescribed maximum system size. A fully nonlinear heat conduction example is selected to illustrate the computational performance of the filtering strategy, against the classical single-filter solution behavior.

  6. Integrability and structural stability of solutions to the Ginzburg-Landau equation

    Science.gov (United States)

    Keefe, Laurence R.

    1986-01-01

    The integrability of the Ginzburg-Landau equation is studied to investigate if the existence of chaotic solutions found numerically could have been predicted a priori. The equation is shown not to possess the Painleveproperty, except for a special case of the coefficients that corresponds to the integrable, nonlinear Schroedinger (NLS) equation. Regarding the Ginzburg-Landau equation as a dissipative perturbation of the NLS, numerical experiments show all but one of a family of two-tori solutions, possessed by the NLS under particular conditions, to disappear under real perturbations to the NLS coefficients of O(10 to the -6th).

  7. PET-MRI: a review of challenges and solutions in the development of integrated multimodality imaging

    CERN Document Server

    Vandenberghe, Stefaan

    2015-01-01

    The integration of positron emission tomography (PET) and magnetic resonance imaging (MRI) has been an ongoing research topic for the last 20 years. This paper gives an overview of the different developments and the technical problems associated with combining PET and MRI in one system. After explaining the different detector concepts for integrating PET-MRI and minimising interference the limitations and advantages of different solutions for the detector and system are described for preclinical and clinical imaging systems. The different integrated PET-MRI systems are described in detail. Besides detector concepts and system integration the challenges and proposed solutions for attenuation correction and the potential for motion correction and resolution recovery are also discussed in this topical review.

  8. Numerical solution of a class of nonlinear two-dimensional integral equations using Bernoulli polynomials

    Directory of Open Access Journals (Sweden)

    Sohrab Bazm

    2016-02-01

    Full Text Available In this study, the Bernoulli polynomials are used to obtain an approximate solution of a class of nonlinear two-dimensional integral equations. To this aim, the operational matrices of integration and the product for Bernoulli polynomials are derived and utilized to reduce the considered problem to a system of nonlinear algebraic equations. Some examples are presented to illustrate the efficiency and accuracy of the method.

  9. Unique Solution of a Coupled Fractional Differential System Involving Integral Boundary Conditions from Economic Model

    Directory of Open Access Journals (Sweden)

    Rui Li

    2013-01-01

    Full Text Available We study the existence and uniqueness of the positive solution for the fractional differential system involving the Riemann-Stieltjes integral boundary conditions , , , , , and , where , , and and are the standard Riemann-Liouville derivatives, and are functions of bounded variation, and and denote the Riemann-Stieltjes integral. Our results are based on a generalized fixed point theorem for weakly contractive mappings in partially ordered sets.

  10. Solution of nonlinear Volterra-Hammerstein integral equations using alternative Legendre collocation method

    Directory of Open Access Journals (Sweden)

    Sohrab Bazm

    2016-11-01

    Full Text Available Alternative Legendre polynomials (ALPs are used to approximate the solution of a class of nonlinear Volterra-Hammerstein integral equations. For this purpose, the operational matrices of integration and the product for ALPs are derived. Then, using the collocation method, the considered problem is reduced into a set of nonlinear algebraic equations. The error analysis of the method is given and the efficiency and accuracy are illustrated by applying the method to some examples.

  11. Numerical solution of linear and nonlinear Fredholm integral equations by using weighted mean-value theorem

    OpenAIRE

    Altürk, Ahmet

    2016-01-01

    Mean value theorems for both derivatives and integrals are very useful tools in mathematics. They can be used to obtain very important inequalities and to prove basic theorems of mathematical analysis. In this article, a semi-analytical method that is based on weighted mean-value theorem for obtaining solutions for a wide class of Fredholm integral equations of the second kind is introduced. Illustrative examples are provided to show the significant advantage of the proposed method over some ...

  12. Integrated Antenna Solutions for Wireless Sensor and Millimeter-Wave Systems

    OpenAIRE

    2009-01-01

    This thesis presents various integrated antenna solutions for different types of systems and applications, e.g. wireless sensors, broadband handsets, advanced base stations, MEMS-based reconfigurable front-ends, automotive anti-collision radars, and large area electronics. For wireless sensor applications, a T-matched dipole is proposed and integrated in an electrically small body-worn sensor node. Measurement techniques are developed to characterize the port impedance and radiation propertie...

  13. Converging micro-nano-bio technologies towards integrated biomedical systems: state of the art and future perspectives under the EU-information & communication technologies program.

    Science.gov (United States)

    Lymberis, A

    2008-01-01

    Research and development at the convergence of microelectronics, nano-materials, biochemistry, measurement technology and information technology is leading to a new class of biomedical systems and applications e.g. molecular imaging, point of care testing, gene therapy and bionics (including on and inside the body sensors and other miniaturised smart systems) which are expected to revolutionise the healthcare provision and quality of life. In particular they are expected to identify diseases at the earliest possible stage, intervene before symptomatic disease becomes apparent and monitor both the progress of the diseases and the effect of intervention and therapeutic procedures. The group of EC-funded projects on Micro-Nano-Bio Convergence Systems, "so-called" MNBS, is made by projects developing systems that use a vast array of technologies to integrate across traditional boundaries between the micro-nano-bio, and info worlds, enabling a wide range of applications from health care to food quality monitoring. It includes mainly two sub-groups, one dealing with systems for in vitro molecular diagnosis and biological/biochemical analysis and the other is dealing with systems for in vivo interaction with the human body. Current status of development and future challenges, technological and socioeconomic, are briefly presented in this paper as background introductory information to the mini-symposium on MNBS. Relevant examples of R&D within the group will be presented in the mini-symposium.

  14. Locally Learning Biomedical Data Using Diffusion Frames

    Science.gov (United States)

    2012-01-01

    expands, increasingly detailed biomedical data must be integrated to betterunderstand normal function and evolution of multifactorial chronic disease ...1259 approach on two standard datasets, we aimed to classify and predict disease progression in AMD patients. Drusen were classified in multispectral...early disease stages in standard and new biomedical datasets. Key words: graphs and networks, machine learning. 1. INTRODUCTION As personalized medicine

  15. On the integrability and quasi-periodic wave solutions of the Boussinesq equation in shallow water

    Science.gov (United States)

    Ma, Pan-Li; Tian, Shou-Fu; Tu, Jian-Min; Xu, Mei-Juan

    2015-05-01

    In this paper, the complete integrability of the Boussinesq equation in shallow water is systematically investigated. By using generalized Bell's polynomials, its bilinear formalism, bilinear Bäcklund transformations, Lax pairs of the Boussinesq equation are constructed, respectively. By virtue of its Lax equations, we find its infinite conservation laws. All conserved densities and fluxes are obtained by lucid recursion formulas. Furthermore, based on multidimensional Riemann theta functions, we construct periodic wave solutions of the Boussinesq equation. Finally, the relations between the periodic wave solutions and soliton solutions are strictly constructed. The asymptotic behaviors of the periodic waves are also analyzed by a limiting procedure.

  16. Travelling wave solutions for the Painleve-integrable coupled KdV equations

    Directory of Open Access Journals (Sweden)

    Xiao-Biao Lin

    2008-06-01

    Full Text Available We study the travelling wave solutions for a system of coupled KdV equations derived by Lou et al [11]. In that paper, they found 5 types of Painleve integrable systems for the coupled KdV system. We show that each of them can be reduced to a partially or completely uncoupled system, through which the dynamical behavior of travelling wave solutions can be determined. In some parameter regions, exact formulas for periodic and solitary waves can be obtained while in other cases, bounded travelling wave solution are discussed.

  17. Design and Realisation of Integrated Circuits for the Readout of Pixel Sensors in High Energy Physics and Biomedical Imaging

    CERN Document Server

    Peric, Ivan

    2004-01-01

    Several application specific microchips (ASICs) for the readout of pixel detectors have been designed, tested and described in this thesis. The first chapter gives the detailed description of the pixel-readout chip for the ATLAS pixel detector (FEI). The chip is now in operation as the innermost electronic component of the ATLAS detector. The chip for steering of DEPFET matrix (SWITCHER) is described in the second chapter. The chip is implemented in a high-voltage CMOS technology, it generates fast high voltage signals. Finally, a novel pixel readout chip for a hybrid x-ray pixel detector based on direct conversion is introduced. The chip (CIX) has joint photon counting and integrating capability.

  18. Telemedicine optoelectronic biomedical data processing system

    Science.gov (United States)

    Prosolovska, Vita V.

    2010-08-01

    The telemedicine optoelectronic biomedical data processing system is created to share medical information for the control of health rights and timely and rapid response to crisis. The system includes the main blocks: bioprocessor, analog-digital converter biomedical images, optoelectronic module for image processing, optoelectronic module for parallel recording and storage of biomedical imaging and matrix screen display of biomedical images. Rated temporal characteristics of the blocks defined by a particular triggering optoelectronic couple in analog-digital converters and time imaging for matrix screen. The element base for hardware implementation of the developed matrix screen is integrated optoelectronic couples produced by selective epitaxy.

  19. Enhancing quality and integrity in biomedical research in Africa: an international call for greater focus, investment and standardisation in capacity strengthening for frontline staff.

    Science.gov (United States)

    Kombe, Francis

    2015-11-13

    The integrity of biomedical research depends heavily on the quality of research data collected. In turn, data quality depends on processes of data collection, a task undertaken by frontline research staff in many research programmes in Africa and elsewhere. These frontline research staff often have additional responsibilities including translating and communicating research in local languages, seeking informed consent for study participation and maintaining supportive relationships between research institutions and study participants and wider communities. The level of skills that fieldworkers need to undertake these responsibilities clearly affects the quality of data collected, the ethics of research 'on the ground' and the short and long term acceptability of research.We organised an international workshop in Kenya in July 2014 to discuss the role of frontline staff in scientific research. A total of 25 field managers from 9 African countries and the UK met for 2.5 days to discuss the relationship between data quality and institutional performance management systems and how they affect career progression and supportive supervision policies of research frontline staff.From this workshop, and supporting an expanding literature on the role of fieldworkers in international health research, participants agreed that fieldworkers' roles present them with practical and ethical challenges that their routine training does not adequately prepare them for. We argue that the common and complex challenges facing fieldworkers should in part be addressed through increased investment and collaborative agreements across types of research institutions in Africa. We call for standardization of core elements of training for this critically important cadre of research staff who perform similar roles and encounter similar challenges in many African settings. Although many valuable training elements are offered in institutions, there is a need to develop broader, more grounded and

  20. Convergence in spectral forward modelling: Binominal series solutions vs. direct integral solutions at high degrees - spherical and ellipsoidal case

    Science.gov (United States)

    Rexer, Moritz; Claessens, Sten; Hirt, Christian

    2016-04-01

    The number of relevant terms of binominal series expansions used in spectral forward modelling of the gravitational potential is known to rise substantially as the resolution of the models increases. Here, we investigate and compare the binominal series expansions in forward modelling w.r.t. a sphere and w.r.t. an ellipsoid (Claessens and Hirt, 2013) in view of high degree forward modelling (d/o 10800). The series in each case depend on different parameters - such as elevation of the topographic function or ellipsoidal radius/co-latitude - and reveal different maximum orders of truncation for a 1% convergence level (=relative error). The results are verified in a real data scenario up to d/o 5400 by spot-checks using direct integral solutions that do not depend on binomial series expansions. As a conclusion, our study demonstrates that for d/o 10800 modelling up to 30 terms of the binominal series accounting for the radial integral are needed within the spherical and the ellipsoidal case, while up to 60 terms are needed for the binominal series accounting for the oblateness of Earth in the ellipsoidal case for a convergence at the 1% level. References: Claessens, S.J.; Hirt, C.: Ellipsoidal topographic potential - new solutions for spectral forward gravity modelling of topography with respect to a reference ellipsoid; Journal of Geophysical Research (JGR) - Solid Earth, Vol. 118, DOI: 10.1002/2013JB010457, 2013.

  1. Numerical solution of optimal control problems using multiple-interval integral Gegenbauer pseudospectral methods

    Science.gov (United States)

    Tang, Xiaojun

    2016-04-01

    The main purpose of this work is to provide multiple-interval integral Gegenbauer pseudospectral methods for solving optimal control problems. The latest developed single-interval integral Gauss/(flipped Radau) pseudospectral methods can be viewed as special cases of the proposed methods. We present an exact and efficient approach to compute the mesh pseudospectral integration matrices for the Gegenbauer-Gauss and flipped Gegenbauer-Gauss-Radau points. Numerical results on benchmark optimal control problems confirm the ability of the proposed methods to obtain highly accurate solutions.

  2. High Speed Solution of Spacecraft Trajectory Problems Using Taylor Series Integration

    Science.gov (United States)

    Scott, James R.; Martini, Michael C.

    2008-01-01

    Taylor series integration is implemented in a spacecraft trajectory analysis code-the Spacecraft N-body Analysis Program (SNAP) - and compared with the code s existing eighth-order Runge-Kutta Fehlberg time integration scheme. Nine trajectory problems, including near Earth, lunar, Mars and Europa missions, are analyzed. Head-to-head comparison at five different error tolerances shows that, on average, Taylor series is faster than Runge-Kutta Fehlberg by a factor of 15.8. Results further show that Taylor series has superior convergence properties. Taylor series integration proves that it can provide rapid, highly accurate solutions to spacecraft trajectory problems.

  3. The first and second monotone integral principles for fundamental solutions of uniformly elliptic equations

    CERN Document Server

    Xiao, Jie

    2009-01-01

    Two optimal monotone integral principles (equivalently for the Laplacian, two sharp iso-weighted-volume inequalities) are established through extending the first and second integral bounds of H. Weinberger for the Green functions (i.e., fundamental solutions) of uniformly elliptic equations in terms of the layer-cake formula, a one-dimensional monotone integral principle, and the isoperimetric and Jenson's inequalities with sharp constants. Surprisingly, a special setting of the first principle can be used to not only verify the low-dimensional P\\'olya conjecture for the principal eigenvalue of the Laplacian but also to characterize the geometry of the Nash inequality for a strong uniform elliptic equation.

  4. On adjoint symmetry equations, integrating factors and solutions of nonlinear ODEs

    Energy Technology Data Exchange (ETDEWEB)

    Guha, Partha [Max Planck Institute for Mathematics in the Sciences, Inselstrasse 22, D-04103 Leipzig (Germany); Choudhury, A Ghose [Department of Physics, Surendranath College, 24/2 Mahatma Gandhi Road, Calcutta-700 009 (India); Khanra, Barun [Sailendra Sircar Vidyalaya, 62A Shyampukur Street, Calcutta-700 004 (India)], E-mail: partha.guha@mis.mpg.de, E-mail: a_ghosechoudhury@rediffmail.com, E-mail: barunkhanra@rediffmail.com

    2009-03-20

    We consider the role of the adjoint equation in determining explicit integrating factors and first integrals of nonlinear ODEs. In Chandrasekar et al (2006 J. Math. Phys. 47 023508), the authors have used an extended version of the Prelle-Singer method for a class of nonlinear ODEs of the oscillator type. In particular, we show that their method actually involves finding a solution of the adjoint symmetry equation. Next, we consider a coupled second-order nonlinear ODE system and derive the corresponding coupled adjoint equations. We illustrate how the coupled adjoint equations can be solved to arrive at a first integral.

  5. Integrating School and Family Counseling: Practical Solutions. The Family Psychology and Counseling Series.

    Science.gov (United States)

    Miller, Lynn D., Ed.

    This book offers practical suggestions for school counselors to begin integrating family counseling methods into their practice, while providing a rationale and the research support for working with families from a school base. It also provides specific techniques for using solution-focused tools, conducting family therapy with children, working…

  6. A Distributed Intranet/Web Solution to Integrated Management of Access Networks

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In this article, we describe the present situation of access network management, enumerate a few problems during the development of network management systems, then put forward a distributed Intranet/Web solution named iMAN to the integrated management of access networks, present its architecture and protocol stack, and describe its application in practice.

  7. A STUDY ON SOME PROBLEMS ON EXISTENCE OF SOLUTIONS FOR NONLINEAR FUNCTIONAL-INTEGRAL EQUATIONS

    Institute of Scientific and Technical Information of China (English)

    DEEPMALA; H.K. PATHAK

    2013-01-01

    In this paper, we prove the existence of solutions of some nonlinear functional-integral equation by using a fixed point theorem which satisfy the Darbo condition. The results extend the corresponding results of many authors. In the sequel, we give an example of our main result to highlight the realized improvements.

  8. Numerical solution of functional integral equations by using B-splines

    Directory of Open Access Journals (Sweden)

    Reza Firouzdor

    2014-05-01

    Full Text Available This paper describes an approximating solution, based on Lagrange interpolation and spline functions, to treat functional integral equations of Fredholm type and Volterra type. This method can be extended to functional dierential and integro-dierential equations. For showing eciency of the method we give some numerical examples.

  9. Stability and Convergence of Solutions to Volterra Integral Equations on Time Scales

    Directory of Open Access Journals (Sweden)

    Eleonora Messina

    2015-01-01

    Full Text Available We consider Volterra integral equations on time scales and present our study about the long time behavior of their solutions. We provide sufficient conditions for the stability and investigate the convergence properties when the kernel of the equations vanishes at infinity.

  10. THE NUMERICAL SOLUTION OF FIRST KIND INTEGRAL EQUATION FOR THE HELMHOLTZ EQUATION ON SMOOTH OPEN ARCS

    Institute of Scientific and Technical Information of China (English)

    Wei-jun Tang; Hong-yuan Fu; Long-jun Shen

    2001-01-01

    Consider solving the Dirichlet problem of Helmholtz equation on unbounded region R2\\Г with Г a smooth open curve in the plane. We use simple-layer potential to construct a solution. This leads to the solution of a logarithmic integral equation of the first kind for the Helmholtz equation. This equation is reformulated using a special change of variable, leading to a new first kind equation with a smooth solution function. This new equation is split into three parts. Then a quadrature method that takes special advantage of the splitting of the integral equation is used to solve the equation numerically. An error analysis in a Sobolev space setting is given. And numerical results show that fast convergence is clearly exhibited.

  11. Accurate integral equation theory for the central force model of liquid water and ionic solutions

    Science.gov (United States)

    Ichiye, Toshiko; Haymet, A. D. J.

    1988-10-01

    The atom-atom pair correlation functions and thermodynamics of the central force model of water, introduced by Lemberg, Stillinger, and Rahman, have been calculated accurately by an integral equation method which incorporates two new developments. First, a rapid new scheme has been used to solve the Ornstein-Zernike equation. This scheme combines the renormalization methods of Allnatt, and Rossky and Friedman with an extension of the trigonometric basis-set solution of Labik and co-workers. Second, by adding approximate ``bridge'' functions to the hypernetted-chain (HNC) integral equation, we have obtained predictions for liquid water in which the hydrogen bond length and number are in good agreement with ``exact'' computer simulations of the same model force laws. In addition, for dilute ionic solutions, the ion-oxygen and ion-hydrogen coordination numbers display both the physically correct stoichiometry and good agreement with earlier simulations. These results represent a measurable improvement over both a previous HNC solution of the central force model and the ex-RISM integral equation solutions for the TIPS and other rigid molecule models of water.

  12. What's keeping people after stroke from walking outdoors to become physically active? A qualitative study, using an integrated biomedical and behavioral theory of functioning and disability.

    Science.gov (United States)

    Outermans, Jacqueline; Pool, Jan; van de Port, Ingrid; Bakers, Japie; Wittink, Harriet

    2016-08-15

    In general people after stroke do not meet the recommendations for physical activity to conduct a healthy lifestyle. Programs to stimulate walking activity to increase physical activity are based on the available insights into barriers and facilitators to physical activity after stroke. However, these programs are not entirely successful. The purpose of this study was to comprehensively explore perceived barriers and facilitators to outdoor walking using a model of integrated biomedical and behavioral theory, the Physical Activity for people with a Disability model (PAD). Included were community dwelling respondents after stroke, classified ≥ 3 at the Functional Ambulation Categories (FAC), purposively sampled regarding the use of healthcare. The data was collected triangulating in a multi-methods approach, i.e. semi-structured, structured and focus-group interviews. A primarily deductive thematic content analysis using the PAD-model in a framework-analysis' approach was conducted after verbatim transcription. 36 respondents (FAC 3-5) participated in 16 semi-structured interviews, eight structured interviews and two focus-group interviews. The data from the interviews covered all domains of the PAD model. Intention, ability and opportunity determined outdoor walking activity. Personal factors determined the intention to walk outdoors, e.g. negative social influence, resulting from restrictive caregivers in the social environment, low self-efficacy influenced by physical environment, and also negative attitude towards physical activity. Walking ability was influenced by loss of balance and reduced walking distance and by impairments of motor control, cognition and aerobic capacity as well as fatigue. Opportunities arising from household responsibilities and lively social constructs facilitated outdoor walking. To stimulate outdoor walking activity, it seems important to influence the intention by addressing social influence, self-efficacy and attitude towards

  13. Elastic-Plastic J-Integral Solutions or Surface Cracks in Tension Using an Interpolation Methodology

    Science.gov (United States)

    Allen, P. A.; Wells, D. N.

    2013-01-01

    No closed form solutions exist for the elastic-plastic J-integral for surface cracks due to the nonlinear, three-dimensional nature of the problem. Traditionally, each surface crack must be analyzed with a unique and time-consuming nonlinear finite element analysis. To overcome this shortcoming, the authors have developed and analyzed an array of 600 3D nonlinear finite element models for surface cracks in flat plates under tension loading. The solution space covers a wide range of crack shapes and depths (shape: 0.2 less than or equal to a/c less than or equal to 1, depth: 0.2 less than or equal to a/B less than or equal to 0.8) and material flow properties (elastic modulus-to-yield ratio: 100 less than or equal to E/ys less than or equal to 1,000, and hardening: 3 less than or equal to n less than or equal to 20). The authors have developed a methodology for interpolating between the goemetric and material property variables that allows the user to reliably evaluate the full elastic-plastic J-integral and force versus crack mouth opening displacement solution; thus, a solution can be obtained very rapidly by users without elastic-plastic fracture mechanics modeling experience. Complete solutions for the 600 models and 25 additional benchmark models are provided in tabular format.

  14. Multiple positive solutions for singular semipositone nonlinear integral boundary-value problems on infinite intervals

    Directory of Open Access Journals (Sweden)

    Ying Wang

    2015-03-01

    Full Text Available In this article, we study the existence of multiple positive solutions for singular semipositone boundary-value problem (BVP with integral boundary conditions on infinite intervals. By using the properties of the Green's function and the Guo-Krasnosel'skii fixed point theorem, we obtain the existence of multiple positive solutions under conditions concerning the nonlinear functions. The method in this article can be used for a large number of problems. We illustrate the validity of our results with an example in the last section.

  15. POSITIVE SOLUTIONS OF A NONLINEAR THREE-POINT EIGENVALUE PROBLEM WITH INTEGRAL BOUNDARY CONDITIONS

    Directory of Open Access Journals (Sweden)

    FAOUZI HADDOUCHI

    2015-11-01

    Full Text Available In this paper, we study the existence of positive solutions of a three-point integral boundary value problem (BVP for the following second-order differential equation u''(t + \\lambda a(tf(u(t = 0; 0 0 is a parameter, 0 <\\eta < 1, 0 <\\alpha < 1/{\\eta}. . By using the properties of the Green's function and Krasnoselskii's fixed point theorem on cones, the eigenvalue intervals of the nonlinear boundary value problem are considered, some sufficient conditions for the existence of at least one positive solutions are established.

  16. Solution-oriented therapy and Rogerian nursing science: an integrated approach.

    Science.gov (United States)

    Tuyn, L K

    1992-04-01

    This article describes an approach to counseling and therapy that integrates concepts from Martha Rogers' science of unitary human beings with a contemporary, strategic school of therapy called brief, solution-oriented therapy. The purpose of this discussion is to stimulate clinicians' interest in solving human problems by creative use of client strengths and patterns of living. A theoretical discussion of Rogers and of solution-oriented therapy is followed by many examples of clinical application from the author's practice. Resources for further learning are recommended.

  17. Jacobi spectral collocation method for the approximate solution of multidimensional nonlinear Volterra integral equation.

    Science.gov (United States)

    Wei, Yunxia; Chen, Yanping; Shi, Xiulian; Zhang, Yuanyuan

    2016-01-01

    We present in this paper the convergence properties of Jacobi spectral collocation method when used to approximate the solution of multidimensional nonlinear Volterra integral equation. The solution is sufficiently smooth while the source function and the kernel function are smooth. We choose the Jacobi-Gauss points associated with the multidimensional Jacobi weight function [Formula: see text] (d denotes the space dimensions) as the collocation points. The error analysis in [Formula: see text]-norm and [Formula: see text]-norm theoretically justifies the exponential convergence of spectral collocation method in multidimensional space. We give two numerical examples in order to illustrate the validity of the proposed Jacobi spectral collocation method.

  18. Online integrated solution to collect data, generate information and manage events in the human biomonitoring field.

    Science.gov (United States)

    Reis, M Fátima; Tedim, João; Aguiar, Pedro; Miguel, J Pereira; Casteleyn, Ludwine; Joas, Reinhard; Van Tongelen, Birgit

    2007-05-01

    In the ambit of Work Package 1 of the ESBIO Project, an online integrated solution to collect data, to generate information, and to manage mainly information-sharing events related with human biomonitoring within Europe has been designed and is being implemented. The present paper summarises the methodological approaches used by the authors as proposers, general promoters and disseminators of this strategic concept, as well as the first outcomes and future actions to be taken, in the short and longer term, to face present and future challenges to make this innovative solution happen.

  19. Database Security for an Integrated Solution to Automate Sales Processes in Banking

    Directory of Open Access Journals (Sweden)

    Alexandra Maria Ioana FLOREA

    2013-05-01

    Full Text Available In order to maintain a competitive edge in a very active banking market the implementation of a web-based solution to standardize, optimize and manage the flow of sales / pre-sales and generating new leads is requested by a company. This article presents the realization of a development framework for software interoperability in the banking financial institutions and an integrated solution for achieving sales process automation in banking. The paper focuses on presenting the requirements for security and confidentiality of stored data and also on presenting the identified techniques and procedures to implement these requirements.

  20. The Library Search Engine: A Smart Solution for Integrating Resources Beyond Library Holdings

    Directory of Open Access Journals (Sweden)

    Karin Herm

    2008-09-01

    Full Text Available The Cooperative Library Network Berlin-Brandenburg (KOBV, Germany addresses the problem of how to integrate resources found outside the library and library holdings into a single discovery tool. It presents a solution that uses open source technology to develop a next-generation catalog interface called the Library Search Engine. This pilot project was launched in 2007 with the library of Albert Einstein Science Park, Potsdam. The idea was to design and develop a fast and convenient search tool, integrating local holdings (books, journals, journal articles as well as relevant scientific subject information such as open access publications and bibliographies.

  1. Continuous-terahertz-wave molecular imaging system for biomedical applications

    Science.gov (United States)

    Zhang, Rui; Zhang, Liangliang; Wu, Tong; Wang, Ruixue; Zuo, Shasha; Wu, Dong; Zhang, Cunlin; Zhang, Jue; Fang, Jing

    2016-07-01

    Molecular imaging techniques are becoming increasingly important in biomedical research and potentially in clinical practice. We present a continuous-terahertz (THz)-wave molecular imaging system for biomedical applications, in which an infrared (IR) laser is integrated into a 0.2-THz reflection-mode continuous-THz-wave imaging system to induce surface plasmon polaritons on the nanoparticles and further improve the intensity of the reflected signal from the water around the nanoparticles. A strong and rapid increment of the reflected THz signal in the nanoparticle solution upon the IR laser irradiation is demonstrated, using either gold or silver nanoparticles. This low-cost, simple, and stable continuous-THz-wave molecular imaging system is suitable for miniaturization and practical imaging applications; in particular, it shows great promise for cancer diagnosis and nanoparticle drug-delivery monitoring.

  2. Explicit analytic approximations for time-dependent solutions of the generalized integrated Michaelis-Menten equation.

    Science.gov (United States)

    Goličnik, Marko

    2011-04-15

    Various explicit reformulations of time-dependent solutions for the classical two-step irreversible Michaelis-Menten enzyme reaction model have been described recently. In the current study, I present further improvements in terms of a generalized integrated form of the Michaelis-Menten equation for computation of substrate or product concentrations as functions of time for more real-world, enzyme-catalyzed reactions affected by the product. The explicit equations presented here can be considered as a simpler and useful alternative to the exact solution for the generalized integrated Michaelis-Menten equation when fitted to time course data using standard curve-fitting software. Copyright © 2011 Elsevier Inc. All rights reserved.

  3. PRECISE INTEGRAL ALGORITHM BASED SOLUTION FOR TRANSIENT INVERSE HEAT CONDUCTION PROBLEMS WITH MULTI-VARIABLES

    Institute of Scientific and Technical Information of China (English)

    WANG Yi-bo; YANG Hai-tian; WU Rui-feng

    2005-01-01

    By modeling direct transient heat conduction problems via finite element method (FEM) and precise integral algorithm, a new approach is presented to solve transient inverse heat conduction problems with multi-variables. Firstly, the spatial space and temporal domain are discretized by FEM and precise integral algorithm respectively. Then, the high accuracy semi-analytical solution of direct problem can be got. Finally, based on the solution, the computing model of inverse problem and expression of sensitivity analysis are established. Single variable and variables combined identifications including thermal parameters, boundary conditions and source-related terms etc. are given to validate the approach proposed in 1-D and 2-D cases. The effects of noise data and initial guess on the results are investigated. The numerical examples show the effectiveness of this approach.

  4. Integral representation of singular solutions to BVP for the wave equation

    Science.gov (United States)

    Nikolov, Aleksey

    2014-12-01

    We consider the Protter problem for the four-dimensional wave equation, where the boundary conditions are posed on a characteristic surface and on a non-characteristic one. In particular, we consider a case when the right-hand side of the equation is of the form of harmonic polynomial. This problem is known to be ill-posed, because its adjoint homogeneous problem has infinitely many nontrivial classical solutions. The solutions of the Protter problem may have strong power type singularity isolated at one boundary point. Bounded solutions are possible only if the right-hand side of the equation is orthogonal to all the classical solutions of the adjoint homogeneous problem, which in fact is a necessary but not sufficient condition for the classical solvability of the problem. In this paper we offer an explicit integral form of the solutions of the problem, which is more simple than the known so far. Additionally, we give a condition on the coefficients of the harmonic polynomial to obtain not only bounded but also continuous solution.

  5. Hybrid Lifting Wavelet-Like Transform for Solution of Electromagnetic Integral Equation

    Institute of Scientific and Technical Information of China (English)

    CHEN Ming-Sheng; WU Xian-Liang; SHA Wei; HUANG Zhi-Xiang

    2008-01-01

    @@ A hybrid lifting wavelet-like transform scheme is successfully applied to the solution of electric field integral equation using Rao-Wilton-Glisson basis functions.To speed up the matrix transform process,the lifting scheme is adopted.Numerical examples of different three-dimensional perfectly electric conducting objects are considered.Compared with the method of moments,the proposed matrix transform scheme can save considerable CPU time and memory.

  6. Integrated Solution of a Back Office System for Serious Games Targeted at Physiotherapy

    OpenAIRE

    Tiago Martins; Vítor Carvalho; Filomena Soares

    2016-01-01

    Serious games targeted at physiotherapy can be a solution to help the physical therapy professionals. However, the entire game management, in its various aspects, is under the professional’s responsibility. One way to reduce the professional management work will be to integrate a Back Office system in the game. Following this trend, the purpose of this paper is to present a modular Back Office system for centralized management of one or more games targeted at physical therapy.

  7. Solution model of nonlinear integral adjustment including different kinds of observing data with different precisions

    Institute of Scientific and Technical Information of China (English)

    郭金运; 陶华学

    2003-01-01

    In order to process different kinds of observing data with different precisions, a new solution model of nonlinear dynamic integral least squares adjustment was put forward, which is not dependent on their derivatives. The partial derivative of each component in the target function is not computed while iteratively solving the problem. Especially when the nonlinear target function is more complex and very difficult to solve the problem, the method can greatly reduce the computing load.

  8. Symmetries, Integrals and Solutions of Ordinary Differential Equations of Maximal Symmetry

    Indian Academy of Sciences (India)

    P G L Leach; R R Warne; N Caister; V Naicker; N Euler

    2010-02-01

    Second-and third-order scalar ordinary differential equations of maximal symmetry in the traditional sense of point, respectively contact, symmetry are examined for the mappings they produce in solutions and fundamental first integrals. The properties of the `exceptional symmetries’, i.e. those not considered to be generic to scalar equations of maximal symmetry, can be recast into a form which is applicable to all such equations of maximal symmetry. Some properties of these symmetries are demonstrated.

  9. Integrated Solution of a Back Office System for Serious Games Targeted at Physiotherapy

    Directory of Open Access Journals (Sweden)

    Tiago Martins

    2016-01-01

    Full Text Available Serious games targeted at physiotherapy can be a solution to help the physical therapy professionals. However, the entire game management, in its various aspects, is under the professional’s responsibility. One way to reduce the professional management work will be to integrate a Back Office system in the game. Following this trend, the purpose of this paper is to present a modular Back Office system for centralized management of one or more games targeted at physical therapy.

  10. Integrating DfM components into a cohesive design-to-silicon solution (Invited Paper)

    Science.gov (United States)

    Liebmann, Lars; Maynard, Dan; McCullen, Kevin; Seong, Nakgeuon; Buturla, Ed; Lavin, Mark; Hibbeler, Jason

    2005-05-01

    Two primary tracks of DfM, one originating from physical design characterization, the other from low-k1 lithography, are described. Examples of specific DfM efforts are given and potentially conflicting layout optimization goals are pointed out. The need for an integrated DfM solution than ties together currently parallel DfM efforts of increasing sophistication and layout impact is identified and a novel DfM-enabling design flow is introduced.

  11. Efficient Integral Equation Solution of Electromagnetic Scattering by Arbitrarily Shaped Objects in Planar, Multilayered Media.

    Science.gov (United States)

    Webb, David Bedford

    The solution of electromagnetic scattering by objects located in planar, multilayered media has long been the subject of active research. For layered-media integral equation solutions via the Method of Moments (MoM), the O(N^2) matrix fill is often prohibitively expensive, even for problems of moderate size. For spatial-domain formulations, this is due to the presence of the Sommerfeld integrals required for obtaining the Green's functions in spatial form. These integrals are completely avoided through use of the complex-image method, which represents the spatial -domain Green's functions in closed form. However, this method is not without limitations, most notably a finite region of validity and an undesirable sensitivity to the choice of requisite parameters. This thesis focuses on methods for overcoming these limitations, to allow robust implementation of the method within the framework of an automated, general-purpose analysis program, applicable to the solution of scattering from arbitrarily shaped objects residing in any number of dielectric layers. Evaluations of several possible improvements to the original complex -image method are presented. A new approach is also presented for representing the angular-dependent Green's function terms that are required when both horizontal and vertical electric currents are present. The complex-image method is applied in this work to the MoM solution of the mixed-potential form of the electric field integral equation (MPIE). Several numerical results are presented for planar and nonplanar objects, including a microstrip patch antenna, wire dipole antennas penetrating dielectric half-spaces, and a microstrip air bridge. These results are compared with measurements or the results from other programs whenever possible. A brief discussion of scattering parameter extraction is also covered, with a comparison of the Prony and Generalized Pencil-of-Functions (GPOF) methods.

  12. Numerical solution of multiple hole problem by using boundary integral equation

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    This paper studies a numerical solution of multiple hole problem by using a boundary integral equation.The studied problem can be considered as a supposition of many single hole problems.After considering the interaction among holes,an algebraic equation is formulated,which is then solved by using an iteration technique.The hoop stress around holes can be finally determined. One numerical example is provided to check its accuracy.

  13. SINGULAR INTEGRAL EQUATIONS WITH COSECANT KERNEL IN SOLUTIONS WITH SINGULARITIES OF ORDER ONE

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    In this article, periodic Riemann boundary value problem with period 2aπ along closed smooth contours is discussed, and thensingular integral equation with kernel csc t-t0/a along closed smooth contours restricted in the strip 0 < Rez < aπ is discussed.Finally, the solutions with singularities of order one for the above two problems are discussed.

  14. LINEAR STIELTJES EQUATION WITH GENERALIZED RIEMANN INTEGRAL AND EXISTENCE OF REGULATED SOLUTIONS

    Institute of Scientific and Technical Information of China (English)

    L. BARBANTI

    2001-01-01

    In this work we establish an existence theorem of regulated solutions for a class of Stieltjes equations which involve generalized Riemann kind of integrals. The general method applied consists in considering the continuous-time Stieltjes equation as limit of discrete processes. This approach will prove fruitful in the study of the controllability of Stieltjes systems, because it will be possible to get properties on the continuous time equation by transferring properties of the discrete ones.

  15. Integrating R and Java for Enhancing Interactivity of Algorithmic Data Analysis Software Solutions

    Directory of Open Access Journals (Sweden)

    Titus Felix FURTUNĂ

    2016-06-01

    Full Text Available Conceiving software solutions for statistical processing and algorithmic data analysis involves handling diverse data, fetched from various sources and in different formats, and presenting the results in a suggestive, tailorable manner. Our ongoing research aims to design programming technics for integrating R developing environment with Java programming language for interoperability at a source code level. The goal is to combine the intensive data processing capabilities of R programing language, along with the multitude of statistical function libraries, with the flexibility offered by Java programming language and platform, in terms of graphical user interface and mathematical function libraries. Both developing environments are multiplatform oriented, and can complement each other through interoperability. R is a comprehensive and concise programming language, benefiting from a continuously expanding and evolving set of packages for statistical analysis, developed by the open source community. While is a very efficient environment for statistical data processing, R platform lacks support for developing user friendly, interactive, graphical user interfaces (GUIs. Java on the other hand, is a high level object oriented programming language, which supports designing and developing performant and interactive frameworks for general purpose software solutions, through Java Foundation Classes, JavaFX and various graphical libraries. In this paper we treat both aspects of integration and interoperability that refer to integrating Java code into R applications, and bringing R processing sequences into Java driven software solutions. Our research has been conducted focusing on case studies concerning pattern recognition and cluster analysis.

  16. Natural hp-BEM for the electric field integral equation with singular solutions

    CERN Document Server

    Bespalov, Alexei

    2010-01-01

    We apply the hp-version of the boundary element method (BEM) for the numerical solution of the electric field integral equation (EFIE) on a Lipschitz polyhedral surface G. The underlying meshes are supposed to be quasi-uniform triangulations of G, and the approximations are based on either Raviart-Thomas or Brezzi-Douglas-Marini families of surface elements. Non-smoothness of G leads to singularities in the solution of the EFIE, severely affecting convergence rates of the BEM. However, the singular behaviour of the solution can be explicitly specified using a finite set of power functions (vertex-, edge-, and vertex-edge singularities). In this paper we use this fact to perform an a priori error analysis of the hp-BEM on quasi-uniform meshes. We prove precise error estimates in terms of the polynomial degree p, the mesh size h, and the singularity exponents.

  17. Extrapolation of Nystrom solution for two dimensional nonlinear Fredholm integral equations

    Science.gov (United States)

    Guoqiang, Han; Jiong, Wang

    2001-09-01

    In this paper, we analyze the existence of asymptotic error expansion of the Nystrom solution for two-dimensional nonlinear Fredholm integral equations of the second kind. We show that the Nystrom solution admits an error expansion in powers of the step-size h and the step-size k. For a special choice of the numerical quadrature, the leading terms in the error expansion for the Nystrom solution contain only even powers of h and k, beginning with terms h2p and k2q. These expansions are useful for the application of Richardson extrapolation and for obtaining sharper error bounds. Numerical examples show that how Richardson extrapolation gives a remarkable increase of precision, in addition to faster convergence.

  18. Effective integration of ultra-elliptic solutions of the focusing nonlinear Schrödinger equation

    Science.gov (United States)

    Wright, O. C.

    2016-05-01

    An effective integration method based on the classical solution of the Jacobi inversion problem, using Kleinian ultra-elliptic functions and Riemann theta functions, is presented for the quasi-periodic two-phase solutions of the focusing cubic nonlinear Schrödinger equation. Each two-phase solution with real quasi-periods forms a two-real-dimensional torus, modulo a circle of complex-phase factors, expressed as a ratio of theta functions associated with the Riemann surface of the invariant spectral curve. The initial conditions of the Dirichlet eigenvalues satisfy reality conditions which are explicitly parametrized by two physically-meaningful real variables: the squared modulus and a scalar multiple of the wavenumber. Simple new formulas for the maximum modulus and the minimum modulus are obtained in terms of the imaginary parts of the branch points of the Riemann surface.

  19. Use of the generalized integral transform method for solving equations of solute transport in porous media

    Science.gov (United States)

    Liu, Chongxuan; Szecsody, Jim E.; Zachara, John M.; Ball, William P.

    The generalized integral transform technique (GITT) is applied to solve the one-dimensional advection-dispersion equation (ADE) in heterogeneous porous media coupled with either linear or nonlinear sorption and decay. When both sorption and decay are linear, analytical solutions are obtained using the GITT for one-dimensional ADEs with spatially and temporally variable flow and dispersion coefficient and arbitrary initial and boundary conditions. When either sorption or decay is nonlinear the solutions to ADEs with the GITT are hybrid analytical-numerical. In both linear and nonlinear cases, the forward and inverse integral transforms for the problems described in the paper are apparent and straightforward. Some illustrative examples with linear sorption and decay are presented to demonstrate the application and check the accuracy of the derived analytical solutions. The derived hybrid analytical-numerical solutions are checked against a numerical approach and demonstratively applied to a nonlinear transport example, which simulates a simplified system of iron oxide bioreduction with nonlinear sorption and nonlinear reaction kinetics.

  20. Co-Leadership – A Management Solution for Integrated Health and Social Care

    Science.gov (United States)

    Hansson, Johan; Hasson, Henna; Sachs, Magna Andreen

    2016-01-01

    Introduction: Co-leadership has been identified as one approach to meet the managerial challenges of integrated services, but research on the topic is limited. In the present study, co-leadership, practised by pairs of managers – each manager representing one of the two principal organizations in integrated health and social care services – was explored. Aim: To investigate co-leadership in integrated health and social care, identify essential preconditions in fulfilling the management assignment, its operationalization and impact on provision of sustainable integration of health and social care. Method: Interviews with eight managers exercising co-leadership were analysed using directed content analysis. Respondent validation was conducted through additional interviews with the same managers. Results: Key contextual preconditions were an organization-wide model supporting co-leadership and co-location of services. Perception of the management role as a collective activity, continuous communication and lack of prestige were essential personal and interpersonal preconditions. In daily practice, office sharing, being able to give and take and support each other contributed to provision of sustainable integration of health and social care. Conclusion and discussion: Co-leadership promoted robust management by providing broader competence, continuous learning and joint responsibility for services. Integrated health and social care services should consider employing co-leadership as a managerial solution to achieve sustainability. PMID:27616963

  1. Co-Leadership – A Management Solution for Integrated Health and Social Care

    Directory of Open Access Journals (Sweden)

    Charlotte Klinga

    2016-05-01

    Full Text Available Introduction: Co-leadership has been identified as one approach to meet the managerial challenges of integrated services, but research on the topic is limited. In the present study, co-leadership, practised by pairs of managers – each manager representing one of the two principal organizations in integrated health and social care services – was explored. Aim: To investigate co-leadership in integrated health and social care, identify essential preconditions in fulfilling the management assignment, its operationalization and impact on provision of sustainable integration of health and social care. Method: Interviews with eight managers exercising co-leadership were analysed using directed content analysis. Respondent validation was conducted through additional interviews with the same managers. Results: Key contextual preconditions were an organization-wide model supporting co-leadership and co-location of services. Perception of the management role as a collective activity, continuous communication and lack of prestige were essential personal and interpersonal preconditions. In daily practice, office sharing, being able to give and take and support each other contributed to provision of sustainable integration of health and social care.  Conclusion and discussion: Co-leadership promoted robust management by providing broader competence, continuous learning and joint responsibility for services. Integrated health and social care services should consider employing co-leadership as a managerial solution to achieve sustainability.

  2. Biomedical applications of collagens.

    Science.gov (United States)

    Ramshaw, John A M

    2016-05-01

    Collagen-based biomedical materials have developed into important, clinically effective materials used in a range of devices that have gained wide acceptance. These devices come with collagen in various formats, including those based on stabilized natural tissues, those that are based on extracted and purified collagens, and designed composite, biosynthetic materials. Further knowledge on the structure and function of collagens has led to on-going developments and improvements. Among these developments has been the production of recombinant collagen materials that are well defined and are disease free. Most recently, a group of bacterial, non-animal collagens has emerged that may provide an excellent, novel source of collagen for use in biomaterials and other applications. These newer collagens are discussed in detail. They can be modified to direct their function, and they can be fabricated into various formats, including films and sponges, while solutions can also be adapted for use in surface coating technologies.

  3. Effects of polydispersity and anisotropy in colloidal and protein solutions: an integral equation approach.

    Science.gov (United States)

    Gazzillo, Domenico; Giacometti, Achille

    2011-12-01

    Application of integral equation theory to complex fluids is reviewed, with particular emphasis to the effects of polydispersity and anisotropy on their structural and thermodynamic properties. Both analytical and numerical solutions of integral equations are discussed within the context of a set of minimal potential models that have been widely used in the literature. While other popular theoretical tools, such as numerical simulations and density functional theory, are superior for quantitative and accurate predictions, we argue that integral equation theory still provides, as in simple fluids, an invaluable technique that is able to capture the main essential features of a complex system, at a much lower computational cost. In addition, it can provide a detailed description of the angular dependence in arbitrary frame, unlike numerical simulations where this information is frequently hampered by insufficient statistics. Applications to colloidal mixtures, globular proteins and patchy colloids are discussed, within a unified framework.

  4. Biomedical engineering fundamentals

    CERN Document Server

    Bronzino, Joseph D

    2014-01-01

    Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering.Biomedical Engineering Fundamentals, the first volume of the handbook, presents material from respected scientists with diverse backgrounds in physiological systems, biomechanics, biomaterials, bioelectric phenomena, and neuroengineering. More than three dozen specific topics are examined, including cardia

  5. Functional integrity of Colossoma macropomum (Cuvier, 1816 sperm cryopreserved with enriched extender solutions

    Directory of Open Access Journals (Sweden)

    Raycon Roberto Freitas Garcia

    Full Text Available Cryoprotectant solutions are used to protect the sperm from alterations caused by the low temperature in the cryopreservation process. We evaluated the quality of Colossoma macropomum semen after freezing, using dimethyl sulfoxide (DMSO as a cryoprotectant, combined with two extender solutions (T1 - Solution 1: Glucose 90.0 g/L, Sodium Citrate 6.0 g/L, EDTA 1.5 g/L, Sodium Bicarbonate 1.5 g/L, Potassium Chloride 0.8 g/L, Gentamycin Sulphate 0.2 g/L, and T2 - Solution 2: Glucose 90.0 g/L, ACP(r-104 10.0 g/L. Motility rate and motility time did not differ between T1 and T2 and were lower than fresh semen. The number of normal sperm was significantly different in treatments T1 (15.1% and T2 (21.9%, and both showed a reduction in the percentage of normal sperm compared to fresh semen (57.4%. The values found for the rates of fertilization and hatching, mitochondrial functionality and sperm DNA, did not differ between the treatments (T1 and T2. Regarding membrane integrity, there was a higher percentage of spermatozoa with intact membranes in T1 (53.4% than T2 (43.7%. The extender solutions, combined with 10% DMSO, maintained the sperm DNA intact in almost all the C. macropomum sperm cells, however there was a loss in their functionality.

  6. Microfluidic Microdialysis: Spatiotemporal Control over Solution Microenvironments Using Integrated Hydrogel Membrane Microwindows

    Directory of Open Access Journals (Sweden)

    Joel S. Paustian

    2013-11-01

    Full Text Available We present a powerful and versatile technique that enables exquisite spatial and temporal control over local solution chemistry in microfluidic devices. Using a microscope and a UV lamp, we use projection lithography to photopolymerize thin (10–25  μm hydrogel membrane “microwindows” (HMMs into standard microfluidic devices. These microwindows are permeable to solute and solvent diffusion and to electric fields, yet act as rigid walls from the standpoint of fluid flow. Reservoirs of solution may thus be rapidly imposed, switched, and maintained on one side of a HMM using standard microfluidic techniques, provoking changes in solution conditions on the other side without active mixing, stirring, or diluting. We highlight three paradigmatic experimental capabilities enabled by HMMs: (1 rapid dialysis and swapping of solute and/or solvent, (2 stable and convection-free localized concentration gradients, and (3 local electric permeability. The functional versatility of hydrogel microwindow membranes, coupled with the ease and speed of their fabrication and integration into simple microchannels or multilayer devices, will open a variety of novel applications and studies in a broad range of fields.

  7. Microfluidic Microdialysis: Spatiotemporal Control over Solution Microenvironments Using Integrated Hydrogel Membrane Microwindows

    Science.gov (United States)

    Paustian, Joel S.; Azevedo, Rodrigo Nery; Lundin, Sean-Thomas B.; Gilkey, Matthew J.; Squires, Todd M.

    2013-10-01

    We present a powerful and versatile technique that enables exquisite spatial and temporal control over local solution chemistry in microfluidic devices. Using a microscope and a UV lamp, we use projection lithography to photopolymerize thin (10-25μm) hydrogel membrane “microwindows” (HMMs) into standard microfluidic devices. These microwindows are permeable to solute and solvent diffusion and to electric fields, yet act as rigid walls from the standpoint of fluid flow. Reservoirs of solution may thus be rapidly imposed, switched, and maintained on one side of a HMM using standard microfluidic techniques, provoking changes in solution conditions on the other side without active mixing, stirring, or diluting. We highlight three paradigmatic experimental capabilities enabled by HMMs: (1) rapid dialysis and swapping of solute and/or solvent, (2) stable and convection-free localized concentration gradients, and (3) local electric permeability. The functional versatility of hydrogel microwindow membranes, coupled with the ease and speed of their fabrication and integration into simple microchannels or multilayer devices, will open a variety of novel applications and studies in a broad range of fields.

  8. Design and analysis of low-power body area networks based on biomedical signals

    Science.gov (United States)

    Hu, Fengye; Li, Shasha; Xue, Tao; Li, Guofeng

    2012-06-01

    A body area network (BAN) as one branch of Sensor Networks, is an inter-disciplinary area which holds great promises for revolutionising the current health care systems. BAN combines the real-time updating of biomedical data with the continuous and dynamic health care monitoring closely. A number of intelligence biomedical sensors can be integrated into a wireless BAN system, and the system can be used for prevention, diagnosis and timely treatment of various medical conditions. In this article, we propose a data fusion technique for a BAN based on biomedical signals. This proposed solution is of much lower complexity than conventional techniques and hence can significantly reduce the power consumption in the BAN. The technology is carried out by removing redundant and unnecessary sample information and shifting a large portion of processing and control loads to the remote control centre in an asymmetric manner. This approach not only reduces the power consumption of biosensor nodes in a BAN, but also ensures the integrity of the biomedical information. In addition, we present a self-designed distributed time-space correlation compressive sensing model and propose an efficient algorithm based on biomedical signals. Simulation results show that the proposed algorithm can not only reconstruct the original signal with high accuracy and but also achieve significant reduction in power consumption.

  9. An integrated solution for photomask manufacturing, handling, and storage at 65 nm and below

    Science.gov (United States)

    Schwitzgebel, Jörg; Xiao, Guangming; Rockwell, Barry; Nozaki, Sammy; Darvish, Ali; Wu, Chris

    2006-03-01

    As reticle line widths shrink and RET complexity increases, even a single sub-micron defect can reject a photomask. High-end reticle manufacturers striving for increased yield and reduced cycle times are relying on low incoming rawstock defect levels and handling via SMIF mini environments for critical manufacturing steps. However, even in SMIF compatible reticle fabs, human handling is often required to load or unload a reticle to/from a SMIF environment. In an effort to provide a fully integrated solution to manufacturing 65 nm and below photomasks, Photronics has introduced a blank inspection/management system developed by Hitachi High Technologies and Fortrend Engineering. The clustered system is capable of robotic transfers in conjunction with blank storage, inspection, and material tracking capabilities. It consists of four major systems: a horizontal mask blank transfer system with state-of-the-art blank sorting capability, an integrated Hitachi GM3000 Mask Blank Surface Inspection System, a totally self-contained and sufficient Mask Blank Storage Station, and a material logistic control software system for material management and SPC. The Fortrend Lamina sorting system has a bright light inspection module for gross particle contamination detection, and a robotic transfer module for mask exchanges between SMIF and other shipping/transport boxes employed in the mask manufacturing facilities. The clustered Hitachi inspection system is an integral part of the solution allowing for additional inspections of stored and incoming blanks by optically detecting foreign particles and pinholes. The data is transferred and stored in the Foretrend handling system control module and may be used for rawstock management and screening based on a predefined criteria. The integrated system provides a total solution to mask manufacturing challenges at 65 nm and below.

  10. Positive Solutions for (n-1,1-Type Singular Fractional Differential System with Coupled Integral Boundary Conditions

    Directory of Open Access Journals (Sweden)

    Ying Wang

    2014-01-01

    Full Text Available We study the positive solutions of the (n-1,1-type fractional differential system with coupled integral boundary conditions. The conditions for the existence of positive solutions to the system are established. In addition, we derive explicit formulae for the estimation of the positive solutions and obtain the unique positive solution when certain additional conditions hold. An example is then given to demonstrate the validity of our main results.

  11. Mechanisms of Methylene Blue Degradation in Three-dimensionally Integrated Micro-solution Plasma

    Science.gov (United States)

    Nomura, Ayano; Hayashi, Yui; Tanaka, Kenji; Shirafuji, Tatsuru; Goto, Motonobu

    2015-09-01

    Plasma in aqueous solution has attracted much attention because they are expected to have possibilities to solve water-related environmental issues. In such application-oriented researches, degradation of methylene blue (MB) or other organic dyes has been widely used for investigating the effects of the plasma treatment on the water with organic contaminants. However, there are few reports on the detailed analysis of the products after the plasma treatment of MB aqueous solution for understanding mechanisms of the degradation processes. We have hence analyzed our degradation products using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry. We have performed the MB degradation in three-dimensionally integrated micro-solution plasma, which has shown 16-fold higher performance in MB degradation than conventional solution plasma. The results of MALDI-TOF mass spectrometry have indicated the formation of sulfoxides in the first stage of the degradation. Then, the methyl groups on the sulfoxides are partially oxidized. The sulfoxides are separated to form two benzene derivatives after that. Finally, weak functional groups are removed from the benzene derivatives.

  12. Reaction mechanisms of methylene-blue degradation in three-dimensionally integrated micro-solution plasma

    Science.gov (United States)

    Shirafuji, Tatsuru; Ishida, Yodai; Nomura, Ayano; Hayashi, Yui; Goto, Motonobu

    2017-06-01

    We have performed matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) on methylene-blue aqueous solutions treated with three-dimensionally integrated micro-solution plasma, in which we have acquired the time evolution of mass spectra as a function of treatment time. The time evolution of mass spectral peak intensities for major detected species has clearly indicated that the parent methylene-blue molecules are degraded through consecutive reactions. The primary reaction is the oxidation of the parent molecules. The oxidized species still have two benzene rings in the parent molecules. The secondary reactions are the separation of the oxidized species and the formation of compounds with one benzene ring. We have also performed the numerical fitting of the time evolution of the mass spectral peak intensities, the results of which have indicated that we must assume additional primary reactions before the primary oxidation for better agreement with experimental results.

  13. Evaluation of Integrated Routing/MAC Solutions for the Diffusion of Warning Messages in VANETs

    Directory of Open Access Journals (Sweden)

    Luca Campelli

    2007-12-01

    Full Text Available The efficiency of routing protocols in general mobile ad hoc networks may be highly affected by the specific Medium Access Control scheme the routing relies upon and by the mobility of the wireless nodes. In this work, we address the design of position based routing solutions for the support of safety oriented applications in Vehicular Ad hoc NETworks (VANETs by focusing on the impact of the MAC layer on the performances of the routing strategies. Namely, we propose a simulation analysis in highway scenarios to assess the routing performance in the two cases where standard IEEE 802.11 technology and a dynamic TDMA scheme are adopted at layer 2 respectively. We discuss on the dimensioning of the routing parameters in both cases and we provide a comparative analysis of the two MAC/routing integrated solutions.

  14. Several Ideas on Integration of SCRUM Practices within Microsoft Solutions Framework

    Directory of Open Access Journals (Sweden)

    Alavandhar Jai Vigneshwar

    2017-05-01

    Full Text Available In order to develop and deliver a software project successfully, any software development organisation has to follow a well-known and recognised software engineering process for successful delivery and maintenance of the software. However, when the organisation is willing to follow a new software development process, the success rate of adopting a new software engineering process is a question mark. In the paper, we aim at studying and comparing two software engineering processes, which are based on different paradigms or models, and proposing a hybrid methodology, which integrates advantages of both compared methods. They are Microsoft Solutions Framework as a representative for an iterative methodology and SCRUM for agile software development. The comparative analysis will help a software development company to make the transition easier from Microsoft Solutions Framework to SCRUM or vice versa.

  15. Existence of positive solutions for singular fractional differential equations with integral boundary conditions

    Directory of Open Access Journals (Sweden)

    Jingfu Jin

    2012-04-01

    Full Text Available This article shows the existence of a positive solution for the singular fractional differential equation with integral boundary condition $$displaylines{ {}^C!D^p u(t=lambda h(tf(t, u(t, quad tin(0, 1, cr u(0-au(1=int^1_0g_0(su(s,ds, cr u'(0-b,{}^C!D^qu(1=int^1_0g_1(su(s,ds, cr u''(0=u'''(0=dots =u^{(n-1}(0=0, }$$ where $lambda $ is a parameter and the nonlinear term is allowed to be singular at $t=0, 1$ and $u=0$. We obtain an explicit interval for $lambda$ such that for any $lambda$ in this interval, existence of at least one positive solution is guaranteed. Our approach is by a fixed point theory in cones combined with linear operator theory.

  16. Symmetries, Integrability and Exact Solutions to the (2+1)-Dimensional Benney Types of Equations

    Science.gov (United States)

    Liu, Han-Ze; Xin, Xiang-Peng

    2016-08-01

    This paper is concerned with the (2+1)-dimensional Benney types of equations. By the complete Lie group classification method, all of the point symmetries of the Benney types of equations are obtained, and the integrable condition of the equation is given. Then, the symmetry reductions and exact solutions to the (2+1)-dimensional nonlinear wave equations are presented. Especially, the shock wave solutions of the Benney equations are investigated by the symmetry reduction and trial function method. Supported by the National Natural Science Foundation of China under Grant Nos. 11171041 and 11505090, Research Award Foundation for Outstanding Young Scientists of Shandong Province under Grant No. BS2015SF009, and the doctorial foundation of Liaocheng University under Grant No. 31805

  17. Miniature Stirling cryocoolers at Thales Cryogenics: qualification results and integration solutions

    Science.gov (United States)

    Arts, R.; Martin, J.-Y.; Willems, D.; Seguineau, C.; de Jonge, G.; Van Acker, S.; Mullié, J.; Le Bordays, J.; Benschop, T.

    2016-05-01

    During the 2015 SPIE-DSS conference, Thales Cryogenics presented new miniature cryocoolers for high operating temperatures. In this paper, an update is given regarding the qualification programme performed on these new products. Integration aspects are discussed, including an in-depth examination of the influence of the dewar cold finger on sizing and performance of the cryocooler. The UP8197 will be placed in the reference frame of the Thales product range of high-reliability linear cryocoolers, while the rotary solution will be considered as the most compact solution in the Thales portfolio. Compatibility of the cryocoolers design with new and existing 1/4" dewar designs is examined, and potential future developments are presented.

  18. Selection of forward osmosis draw solutes for subsequent integration with anaerobic treatment to facilitate resource recovery from wastewater.

    Science.gov (United States)

    Ansari, Ashley J; Hai, Faisal I; Guo, Wenshan; Ngo, Hao H; Price, William E; Nghiem, Long D

    2015-09-01

    Forward osmosis (FO) can be used to extract clean water and pre-concentrate municipal wastewater to make it amenable to anaerobic treatment. A protocol was developed to assess the suitability of FO draw solutes for pre-concentrating wastewater for potential integration with anaerobic treatment to facilitate resource recovery from wastewater. Draw solutes were evaluated in terms of their ability to induce osmotic pressure, water flux, and reverse solute flux. The compatibility of each draw solute with subsequent anaerobic treatment was assessed by biomethane potential analysis. The effect of each draw solute (at concentrations corresponding to the reverse solute flux at ten-fold pre-concentration of wastewater) on methane production was also evaluated. The results show that ionic organic draw solutes (e.g., sodium acetate) were most suitable for FO application and subsequent anaerobic treatment. On the other hand, the reverse solute flux of inorganic draw solutions could inhibit methane production from FO pre-concentrated wastewater.

  19. Biomedical photonics handbook therapeutics and advanced biophotonics

    CERN Document Server

    Vo-Dinh, Tuan

    2014-01-01

    Shaped by Quantum Theory, Technology, and the Genomics RevolutionThe integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents recent fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers,

  20. Optomechatronics for Biomedical Optical Imaging: An Overview

    OpenAIRE

    Cho Hyungsuck

    2015-01-01

    The use of optomechatronic technology, particularly in biomedical optical imaging, is becoming pronounced and ever increasing due to its synergistic effect of the integration of optics and mechatronics. The background of this trend is that the biomedical optical imaging for example in-vivo imaging related to retraction of tissues, diagnosis, and surgical operations have a variety of challenges due to complexity in internal structure and properties of biological body and the resulting optical ...

  1. Existence of Solutions to Nonlinear Impulsive Volterra Integral Equations in Banach Spaces

    Institute of Scientific and Technical Information of China (English)

    CHEN Fangqi; TIAN Ruilan

    2005-01-01

    In this paper, the existence of solutions is studied for nonlinear impulsive Volterra integral equations with infinite moments of impulse effect on the half line R+ in Banach spaces.By the use of a new comparison result and recurrence method, the new existence theorems are achieved under a weaker compactness-type condition, which generalize and improve the related results for this class of equations with finite moments of impulse effect on finite interval and infinite moments of impulse effect on infinite interval.

  2. Performance Analysis of Constrained Loosely Coupled GPS/INS Integration Solutions

    Directory of Open Access Journals (Sweden)

    Fabio Dovis

    2012-11-01

    Full Text Available The paper investigates approaches for loosely coupled GPS/INS integration. Error performance is calculated using a reference trajectory. A performance improvement can be obtained by exploiting additional map information (for example, a road boundary. A constrained solution has been developed and its performance compared with an unconstrained one. The case of GPS outages is also investigated showing how a Kalman filter that operates on the last received GPS position and velocity measurements provides a performance benefit. Results are obtained by means of simulation studies and real data.

  3. CLASSIFICATION OF POSITIVE SOLUTIONS FOR NONLINEAR DIFFERENTIAL AND INTEGRAL SYSTEMS WITH CRITICAL EXPONENTS

    Institute of Scientific and Technical Information of China (English)

    Wenxiong Chen; Congming Li

    2009-01-01

    We classify all positive solutions for the following integral system……Here fi(u), 1≤i≤m, are real-valued functions of homogeneous degree n+α/n-α and aremonotone nondecreasing with respect to all the independent variables u1, u2, ..', um. In the special case n>3 and α= 2, we show that the above system is equivalent to the following elliptic PDE system………This system is closely related to the stationary Schrodinger system with critical exponents for Bose-Einstein condensate.

  4. SOLUTION OF DIFFERENT HOLES SHAPE BORDERS OF FIBRE REINFORCED COMPOSITE PLATES BY INTEGRAL EQUATIONS

    Institute of Scientific and Technical Information of China (English)

    LI Cheng; ZHENG Yanping; CHEN Zhongzhong

    2007-01-01

    Accurate boundary conditions of composite material plates with different holes are founded to settle boundary condition problems of complex holes by conformal mapping method upon the nonhomogeneous anisotropic elastic and complex function theory. And then the two stress functions required were founded on Cauchy integral by boundary conditions. The final stress distributions of opening structure and the analytical solution on composite material plate with rectangle hole and wing manholes were achieved. The influences on hole-edge stress concentration factors are discussed under different loads and fiber direction cases, and then contrast calculates are carried through FEM.

  5. Elliptical vortex solutions, integrable Ermakov structure, and Lax pair formulation of the compressible Euler equations.

    Science.gov (United States)

    An, Hongli; Fan, Engui; Zhu, Haixing

    2015-01-01

    The 2+1-dimensional compressible Euler equations are investigated here. A power-type elliptic vortex ansatz is introduced and thereby reduction obtains to an eight-dimensional nonlinear dynamical system. The latter is shown to have an underlying integral Ermakov-Ray-Reid structure of Hamiltonian type. It is of interest to notice that such an integrable Ermakov structure exists not only in the density representations but also in the velocity components. A class of typical elliptical vortex solutions termed pulsrodons corresponding to warm-core eddy theory is isolated and its behavior is simulated. In addition, a Lax pair formulation is constructed and the connection with stationary nonlinear cubic Schrödinger equations is established.

  6. Economical bridge solutions based on innovative composite dowels and integrated abutments ecobridge

    CERN Document Server

    Băncilă, Radu

    2015-01-01

    This book is an outcome of the research project “ECOBRIDGE – Demonstration of ECOnomical BRIDGE solutions based on innovative composite dowels and integrated abutments – RFCS – CT 2010-00024”, which has been co-funded by the Research Fund for Coal and Steel (R.F.C.S.) of the European Community. The main topics of the book are the following: design of integral bridges, innovative composite dowels for the shear transmission, construction of bridges, structural analysis of bridges and monitoring. The book joins the technical experience and the contributions of the involved research partners. The technical content of all the papers is present-day in the field of the design, construction and monitoring of innovative composite bridges. The efficient design and construction improve and consolidate the market position of steel construction and steel producing industry. In addition, the advanced forms of construction are contributing to savings in material and energy consumption for the structure during prod...

  7. An Integrated Water Treatment Technology Solution for Sustainable Water Resource Management in the Marcellus Shale

    Energy Technology Data Exchange (ETDEWEB)

    Matthew Bruff; Ned Godshall; Karen Evans

    2011-04-30

    This Final Scientific/ Technical Report submitted with respect to Project DE-FE0000833 titled 'An Integrated Water Treatment Technology Solution for Sustainable Water Resource Management in the Marcellus Shale' in support of final reporting requirements. This final report contains a compilation of previous reports with the most current data in order to produce one final complete document. The goal of this research was to provide an integrated approach aimed at addressing the increasing water resource challenges between natural gas production and other water stakeholders in shale gas basins. The objective was to demonstrate that the AltelaRain{reg_sign} technology could be successfully deployed in the Marcellus Shale Basin to treat frac flow-back water. That objective has been successfully met.

  8. Existence of Nondecreasing and Continuous Solutions of an Integral Equation with Linear Modification of the Argument

    Institute of Scientific and Technical Information of China (English)

    J. CABALLERO; B. L(ó)PEZ; K. SADARANGANI

    2007-01-01

    We use a technique associated with measures of noncompactness to prove the existence of nondecreasing solutions to an integral equation with linear modification of the argument in the space C[0,1]. In the last thirty years there has been a great deal of work in the field of differential equations with a modified argument. A special class is represented by the differential equation with affine modification of the argument which can be delay differential equations or differential equations with linear modifications of the argument. In this case we study the following integral equation x(t) = a(t) + (Tx)(t)∫σ(t)o u(t,s,x(s),x(λs))ds 0λ1 which can be considered in connection with the following Cauchy problem x'(t) = u(t,s,x(t),x(λt)), t∈[0,1], 0 λ 1 x(0) = uo.

  9. Review on Malaysian Rail Transit Operation and Management System: Issues and Solution in Integration

    Science.gov (United States)

    Masirin, Mohd Idrus Mohd; Salin, Aminah Mohd; Zainorabidin, Adnan; Martin, David; Samsuddin, Norshakina

    2017-08-01

    In any context, operation and management of transportation systems are key issues which may affect both life quality and economic development. In large urban agglomerations, an efficient public transportation system may help abate the negative externalities of private car use such as congestion, air and noise pollution, accident and fuel consumption, without excessively penalizing user travel times or zone accessibility. Thus, this study is conducted to appraise the Malaysian rural rail transit operation and management system, which are considered important as there are many issues and solution in integration of the services that need to be tackled more conscientiously. The purpose of this paper is to describe some of the most important issues on integration of services and rail transit system in Malaysian and how to solve or reduce these problems and conflicts. In this paper, it consists of the historical development of rail transit construction in Malaysia. This paper also attempts to identify the important issues related to rail transit services and integration in Malaysian rural rail operation and management system. Comparison is also conducted with other countries such as UK, France, and Japan. Finally, a critical analysis is presented in this paper by looking at the possible application for future Malaysian rail transit operation system and management, especially focusing on enhancing the quality of Malaysian rural rail transit. In conclusion, this paper is expected to successfully review and appraise the existing Malaysian rural rail transit operation and management system pertaining to issues & solution in integration. It is also hoped that reformation or transformation of present service delivery quality of the rail transit operation and management will enable Malaysia to succeed in transforming Malaysian transportation system to greater heights.

  10. An integrated radar model solution for mission level performance and cost trades

    Science.gov (United States)

    Hodge, John; Duncan, Kerron; Zimmerman, Madeline; Drupp, Rob; Manno, Mike; Barrett, Donald; Smith, Amelia

    2017-05-01

    A fully integrated Mission-Level Radar model is in development as part of a multi-year effort under the Northrop Grumman Mission Systems (NGMS) sector's Model Based Engineering (MBE) initiative to digitally interconnect and unify previously separate performance and cost models. In 2016, an NGMS internal research and development (IR and D) funded multidisciplinary team integrated radio frequency (RF), power, control, size, weight, thermal, and cost models together using a commercial-off-the-shelf software, ModelCenter, for an Active Electronically Scanned Array (AESA) radar system. Each represented model was digitally connected with standard interfaces and unified to allow end-to-end mission system optimization and trade studies. The radar model was then linked to the Air Force's own mission modeling framework (AFSIM). The team first had to identify the necessary models, and with the aid of subject matter experts (SMEs) understand and document the inputs, outputs, and behaviors of the component models. This agile development process and collaboration enabled rapid integration of disparate models and the validation of their combined system performance. This MBE framework will allow NGMS to design systems more efficiently and affordably, optimize architectures, and provide increased value to the customer. The model integrates detailed component models that validate cost and performance at the physics level with high-level models that provide visualization of a platform mission. This connectivity of component to mission models allows hardware and software design solutions to be better optimized to meet mission needs, creating cost-optimal solutions for the customer, while reducing design cycle time through risk mitigation and early validation of design decisions.

  11. What should biomedical sciences education in dental schools achieve?

    Science.gov (United States)

    Lantz, M S; Chaves, J F

    1997-05-01

    Education for the first professional degree in dentistry is intended to produce graduates capable of offering a wide range of high quality dental services to the general public. More than that, it is expected that graduates will be firmly grounded in the scientific basis for their professional practices and be equipped to evaluate critically and integrate selectively new scientific findings that emerge during their professional lifetimes. In addition, they are expected to be able to work effectively with diverse patient populations and to conduct their practices with a high level of sensitivity to the ethical and psychosocial dimensions of patient care. Indiana University School of Dentistry has undergone a process of curriculum reform that has yielded a new first professional degree program. Its hallmarks are large, multidisciplinary courses (seven courses in the first two years) that are taught using a variety of strategies including problem-based learning in small groups as well as lectures. The biomedical sciences curriculum is concept-based. Students will demonstrate their understanding of science concepts and methods by applying them to the solution of research and health care problems. Biomedical sciences will be taught at a level that will provide a comprehensive understanding of the functioning of the human body in health and disease, allow students to assimilate the coming revolution in molecular medicine, and selectively use new diagnostics, preventives, and therapeutics that evolve as molecular biological technologies yield solutions to current medical and dental problems. Using the biomedical sciences curriculum as a vehicle, we will also achieve the goal of training dentists as critical thinkers, problem solvers, lifelong learners, and ethical practitioners, skillful in peer and self-evaluation, and cognizant of the psychosocial as well as biomedical perspective of health and disease.

  12. An integral equation approach to smooth 3D Navier-Stokes solution

    Science.gov (United States)

    Costin, O.; Luo, G.; Tanveer, S.

    2008-12-01

    We summarize a recently developed integral equation (IE) approach to tackling the long-time existence problem for smooth solution v(x, t) to the 3D Navier-Stokes (NS) equation in the context of a periodic box problem with smooth time independent forcing and initial condition v0. Using an inverse-Laplace transform of {\\skew5\\hat v} (k, t) - {\\skew5\\hat v}_0 in 1/t, we arrive at an IE for {\\skew5\\hat U} (k, p) , where p is inverse-Laplace dual to 1/t and k is the Fourier variable dual to x. The advantage of this formulation is that the solution {\\skew5\\hat U} to the IE is known to exist a priori for p \\in \\mathbb{R}^+ and the solution is integrable and exponentially bounded at ∞. Global existence of NS solution in this formulation is reduced to an asymptotics question. If \\parallel\\!{\\skew5\\hat U} (\\cdot, p)\\!\\parallel_{{l^{1} (\\mathbb{Z}^3)}} has subexponential bounds as p→∞, then global existence to NS follows. Moreover, if f=0, then the converse is also true in the following sense: if NS has global solution, then there exists n>=1 for which the inverse-Laplace transform of {\\skew5\\hat v} (k, t) - {\\skew5\\hat v}_0 in 1/tn necessarily decays as q→∞, where q is the inverse-Laplace dual to 1/tn. We also present refined estimates of the exponential growth when the solution {\\skew5\\hat U} is known on a finite interval [0, p0]. We also show that for analytic v[0] and f, with finitely many nonzero Fourier-coefficients, the series for {\\skew5\\hat U} (k, p) in powers of p has a radius of convergence independent of initial condition and forcing; indeed the radius gets bigger for smaller viscosity. We also show that the IE can be solved numerically with controlled errors. Preliminary numerical calculations for Kida (1985 J. Phys. Soc. Japan 54 2132) initial conditions, though far from being optimized, and performed on a modest interval in the accelerated variable q show decay in q.

  13. Asymptotically Stable Solutions of a Generalized Fractional Quadratic Functional-Integral Equation of Erdélyi-Kober Type

    Directory of Open Access Journals (Sweden)

    Mohamed Abdalla Darwish

    2014-01-01

    Full Text Available We study a generalized fractional quadratic functional-integral equation of Erdélyi-Kober type in the Banach space BC(ℝ+. We show that this equation has at least one asymptotically stable solution.

  14. ORTHOGONAL POLYNOMIALS AND DETERMINANT FORMULAS OF FUNCTION-VALUED PAD(E)-TYPE APPROXIMATION USING FOR SOLUTION OF INTEGRAL EQUATIONS

    Institute of Scientific and Technical Information of China (English)

    GU Chuan-qing; PAN Bao-zhen; WU Bei-bei

    2006-01-01

    To solve Fredholm integral equations of the second kind, a generalized linear functional is introduced and a new function-valued Padé-type approximation is defined.By means of the power series expansion of the solution, this method can construct an approximate solution to solve the given integral equation. On the basis of the orthogonal polynomials, two useful determinant expressions of the numerator polynomial and the denominator polynomial for padé-type approximation are explicitly given.

  15. Integrated PEV Charging Solutions and Reduced Energy for Occupant Comfort (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2012-01-01

    Brochure on Vehicle Testing and Integration Facility, featuring the Vehicle Modification Facility, Vehicle Test Pad and ReCharge Integrated Demonstration System. Plug-in electric vehicles (PEVs) offer the opportunity to shift transportation energy demands from petroleum to electricity, but broad adoption will require integration with other systems. While automotive experts work to reduce the cost of PEVs, fossil fueled cars and trucks continue to burn hundreds of billions of gallons of petroleum each year - not only to get from point A to point B, but also to keep passengers comfortable with air conditioning and heat. At the National Renewable Energy Laboratory (NREL), three installations form a research laboratory known as the Vehicle Testing and Integration Facility (VTIF). At the VTIF, engineers are developing strategies to address two separate but equally crucial areas of research: meeting the demands of electric vehicle-grid integration and minimizing fuel consumption related to vehicle climate control. Part of NREL's Center for Transportation Technologies and Systems (CTTS), the VTIF is dedicated to renewable and energy efficient solutions. This facility showcases technology and systems designed to increase the viability of sustainably powered vehicles. NREL researchers instrument every class of on-road vehicle, conduct hardware and software validation for electric vehicle (EV) components and accessories, and develop analysis tools and technology for the Department of Energy, other government agencies and industry partners. Research conducted at the VTIF examines the interaction of building energy systems, utility grids, renewable energy sources and PEVs, integrating energy management solutions, and maximizing potential greenhouse gas (GHG) reduction, while smoothing the transition and reducing costs for EV owners. NREL's collaboration with automakers, charging station manufacturers, utilities and fleet operators to assess technologies using VTIF

  16. An integral transform solution for unsteady compressible heat transfer in fluids near their thermodynamic critical point

    Directory of Open Access Journals (Sweden)

    de B. Alves Leonardo S.

    2013-01-01

    Full Text Available The classical thermodynamic model for near critical heat transfer is an integral-differential equation with constant coefficients. It is similar to the heat equation, except for a source term containing the time derivative of the bulk temperature. Despite its simple form, analytical methods required the use of approximations to generate solutions for it, such as an approximate Fourier transformation or a numerical Laplace inversion. Recently, the Generalized Integral Transform Technique or GITT has been successfully applied to this problem, providing a highly accurate analytical solution for it and a new expression of its relaxation time. Nevertheless, very small temperature differences, on the order of mK, have to be imposed so that constant thermal properties can be assumed very close to the critical point. The present paper generalizes this study by relaxing its restriction and accounting for the strong dependence on temperature and pressure of supercritical fluid properties, demonstrating that a the GITT can be applied to realistic nonlinear unsteady compressible heat transfer in fluids with diverging thermal properties and b temperature and pressure have opposite effects on all properties, but their variation causes no additional thermo-acoustic effect, increasing the validity range of the constant property model.

  17. Path-integral solution of the one-dimensional Dirac quantum cellular automaton

    Energy Technology Data Exchange (ETDEWEB)

    D' Ariano, Giacomo Mauro [QUIT group, Dipartimento di Fisica, via Bassi 6, Pavia, 27100 (Italy); INFN Gruppo IV, Sezione di Pavia, via Bassi 6, Pavia, 27100 (Italy); Mosco, Nicola [QUIT group, Dipartimento di Fisica, via Bassi 6, Pavia, 27100 (Italy); Perinotti, Paolo [QUIT group, Dipartimento di Fisica, via Bassi 6, Pavia, 27100 (Italy); INFN Gruppo IV, Sezione di Pavia, via Bassi 6, Pavia, 27100 (Italy); Tosini, Alessandro [QUIT group, Dipartimento di Fisica, via Bassi 6, Pavia, 27100 (Italy)

    2014-09-05

    Quantum cellular automata, which describe the discrete and exactly causal unitary evolution of a lattice of quantum systems, have been recently considered as a fundamental approach to quantum field theory and a linear automaton for the Dirac equation in one dimension has been derived. In the linear case a quantum cellular automaton is isomorphic to a quantum walk and its evolution is conveniently formulated in terms of transition matrices. The semigroup structure of the matrices leads to a new kind of discrete path-integral, different from the well known Feynman checkerboard one, that is solved analytically in terms of Jacobi polynomials of the arbitrary mass parameter. - Highlights: • Discrete path integral formulation of linear QCAs in terms of transition matrices. • Derivation of the analytical solution for the one dimensional Dirac QCA. • Solution given in terms of Jacobi polynomials versus the arbitrary mass parameter. • The discrete paths and the transition matrices of the Dirac QCA are binary encoded. • Paths are grouped in equivalence classes according to their overall transition matrix.

  18. Uniqueness and Asymptotic Behavior of Positive Solutions for a Fractional-Order Integral Boundary Value Problem

    Directory of Open Access Journals (Sweden)

    Min Jia

    2012-01-01

    Full Text Available We study a model arising from porous media, electromagnetic, and signal processing of wireless communication system -tαx(t=f(t,x(t,x'(t,x”(t,…,x(n-2(t,  0integrals, A is a function of bounded variation, and dA can be a changing-sign measure. The existence, uniqueness, and asymptotic behavior of positive solutions to the singular nonlocal integral boundary value problem for fractional differential equation are obtained. Our analysis relies on Schauder's fixed-point theorem and upper and lower solution method.

  19. On Solutions of the Integrable Boundary Value Problem for KdV Equation on the Semi-Axis

    Energy Technology Data Exchange (ETDEWEB)

    Ignatyev, M. Yu., E-mail: ignatievmu@info.sgu.ru [Saratov State University, Department of Mathematics (Russian Federation)

    2013-03-15

    This paper is concerned with the Korteweg-de Vries (KdV) equation on the semi-axis. The boundary value problem with inhomogeneous integrable boundary conditions is studied. We establish some characteristic properties of solutions of the problem. Also we construct a wide class of solutions of the problem using the inverse spectral method.

  20. Modernizing Distribution System Restoration to Achieve Grid Resiliency Against Extreme Weather Events: An Integrated Solution

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Chen; Wang, Jianhui; Ton, Dan

    2017-07-01

    Recent severe power outages caused by extreme weather hazards have highlighted the importance and urgency of improving the resilience of the electric power grid. As the distribution grids still remain vulnerable to natural disasters, the power industry has focused on methods of restoring distribution systems after disasters in an effective and quick manner. The current distribution system restoration practice for utilities is mainly based on predetermined priorities and tends to be inefficient and suboptimal, and the lack of situational awareness after the hazard significantly delays the restoration process. As a result, customers may experience an extended blackout, which causes large economic loss. On the other hand, the emerging advanced devices and technologies enabled through grid modernization efforts have the potential to improve the distribution system restoration strategy. However, utilizing these resources to aid the utilities in better distribution system restoration decision-making in response to extreme weather events is a challenging task. Therefore, this paper proposes an integrated solution: a distribution system restoration decision support tool designed by leveraging resources developed for grid modernization. We first review the current distribution restoration practice and discuss why it is inadequate in response to extreme weather events. Then we describe how the grid modernization efforts could benefit distribution system restoration, and we propose an integrated solution in the form of a decision support tool to achieve the goal. The advantages of the solution include improving situational awareness of the system damage status and facilitating survivability for customers. The paper provides a comprehensive review of how the existing methodologies in the literature could be leveraged to achieve the key advantages. The benefits of the developed system restoration decision support tool include the optimal and efficient allocation of repair

  1. Integrated solution for the complete remote sensing process - Earth Observation Mission Control Centre (EOMC2)

    Science.gov (United States)

    Czapski, Paweł

    2016-07-01

    We are going to show the latest achievements of the Remote Sensing Division of the Institute of Aviation in the area of remote sensing, i.e. the project of the integrated solution for the whole remote sensing process ranging from acquiring to providing the end user with required information. Currently, these tasks are partially performed by several centers in Poland, however there is no leader providing an integrated solution. Motivated by this fact, the Earth Observation Mission Control Centre (EOMC2) was established in the Remote Sensing Division of the Institute of Aviation that will provide such a comprehensive approach. Establishing of EOMC2 can be compared with creating Data Center Aerial and Satellite Data Centre (OPOLIS) in the Institute of Geodesy and Cartography in the mid-70s in Poland. OPOLIS was responsible for broadly defined data processing, it was a breakthrough innovation that initiated the use of aerial image analysis in Poland. Operation center is a part of the project that will be created, which in comparison with the competitors will provide better solutions, i.e.: • Centralization of the acquiring, processing, publishing and archiving of data, • Implementing elements of the INSPIRE directive recommendations on spatial data management, • Providing the end-user with information in the near real-time, • Ability of supplying the system with images of various origin (aerial, satellite, e.g. EUMETCast, Sentinel, Landsat) and diversity of telemetry data, data aggregation and using the same algorithms to images obtained from different sources, • System reconfiguration and batch processing of large data sets at any time, • A wide range of potential applications: precision agriculture, environmental protection, crisis management and national security, aerial, small satellite and sounding rocket missions monitoring.

  2. MobiPag: Integrated Mobile Payment, Ticketing and Couponing Solution Based on NFC †

    Science.gov (United States)

    Rodrigues, Helena; José, Rui; Coelho, André; Melro, Ana; Ferreira, Marta Campos; Cunha, João Falcão e; Monteiro, Miguel Pimenta; Ribeiro, Carlos

    2014-01-01

    Mobile payments still remain essentially an emerging technology, seeking to fill the gap between the envisioned potential and widespread usage. In this paper, we present an integrated mobile service solution based on the near field communication (NFC) protocol that was developed under a research project called MobiPag. The most distinctive characteristic of Mobipag is its open architectural model that allows multiple partners to become part of the payment value-chain and create solutions that complement payments in many unexpected ways. We describe the Mobipag architecture and how it has been used to support a mobile payment trial. We identify a set of design lessons resulting from usage experiences associated with real-world payment situations with NFC-enabled mobile phones. Based on results from this trial, we identify a number of challenges and guidelines that may help to shape future versions of NFC-based payment systems. In particular, we highlight key challenges for the initial phases of payment deployments, where it is essential to focus on scenarios that can be identified as more feasible for early adoption. We also have identified a fundamental trade-off between the flexibility supported by the Mobipag solution and the respective implications for the payment process, particularly on the users' mental model. PMID:25061838

  3. MobiPag: integrated mobile payment, ticketing and couponing solution based on NFC.

    Science.gov (United States)

    Rodrigues, Helena; José, Rui; Coelho, André; Melro, Ana; Ferreira, Marta Campos; Falcão e Cunha, João; Monteiro, Miguel Pimenta; Ribeiro, Carlos

    2014-07-24

    Mobile payments still remain essentially an emerging technology, seeking to fill the gap between the envisioned potential and widespread usage. In this paper, we present an integrated mobile service solution based on the near field communication (NFC) protocol that was developed under a research project called MobiPag. The most distinctive characteristic of Mobipag is its open architectural model that allows multiple partners to become part of the payment value-chain and create solutions that complement payments in many unexpected ways. We describe the Mobipag architecture and how it has been used to support a mobile payment trial. We identify a set of design lessons resulting from usage experiences associated with real-world payment situations with NFC-enabled mobile phones. Based on results from this trial, we identify a number of challenges and guidelines that may help to shape future versions of NFC-based payment systems. In particular, we highlight key challenges for the initial phases of payment deployments, where it is essential to focus on scenarios that can be identified as more feasible for early adoption. We also have identified a fundamental trade-off between the flexibility supported by the Mobipag solution and the respective implications for the payment process, particularly on the users' mental model.

  4. MobiPag: Integrated Mobile Payment, Ticketing and Couponing Solution Based on NFC

    Directory of Open Access Journals (Sweden)

    Helena Rodrigues

    2014-07-01

    Full Text Available Mobile payments still remain essentially an emerging technology, seeking to fill the gap between the envisioned potential and widespread usage. In this paper, we present an integrated mobile service solution based on the near field communication (NFC protocol that was developed under a research project called MobiPag. The most distinctive characteristic of Mobipag is its open architectural model that allows multiple partners to become part of the payment value-chain and create solutions that complement payments in many unexpected ways. We describe the Mobipag architecture and how it has been used to support a mobile payment trial. We identify a set of design lessons resulting from usage experiences associated with real-world payment situations with NFC-enabled mobile phones. Based on results from this trial, we identify a number of challenges and guidelines that may help to shape future versions of NFC-based payment systems. In particular, we highlight key challenges for the initial phases of payment deployments, where it is essential to focus on scenarios that can be identified as more feasible for early adoption. We also have identified a fundamental trade-off between the flexibility supported by the Mobipag solution and the respective implications for the payment process, particularly on the users’ mental model.

  5. Boundary integral equation methods and numerical solutions thin plates on an elastic foundation

    CERN Document Server

    Constanda, Christian; Hamill, William

    2016-01-01

    This book presents and explains a general, efficient, and elegant method for solving the Dirichlet, Neumann, and Robin boundary value problems for the extensional deformation of a thin plate on an elastic foundation. The solutions of these problems are obtained both analytically—by means of direct and indirect boundary integral equation methods (BIEMs)—and numerically, through the application of a boundary element technique. The text discusses the methodology for constructing a BIEM, deriving all the attending mathematical properties with full rigor. The model investigated in the book can serve as a template for the study of any linear elliptic two-dimensional problem with constant coefficients. The representation of the solution in terms of single-layer and double-layer potentials is pivotal in the development of a BIEM, which, in turn, forms the basis for the second part of the book, where approximate solutions are computed with a high degree of accuracy. The book is intended for graduate students and r...

  6. On the Intramolecular Hydrogen Bond in Solution: Car-Parrinello and Path Integral Molecular Dynamics Perspective.

    Science.gov (United States)

    Dopieralski, Przemyslaw; Perrin, Charles L; Latajka, Zdzislaw

    2011-11-08

    The issue of the symmetry of short, low-barrier hydrogen bonds in solution is addressed here with advanced ab initio simulations of a hydrogen maleate anion in different environments, starting with the isolated anion, going through two crystal structures (sodium and potassium salts), then to an aqueous solution, and finally in the presence of counterions. By Car-Parrinello and path integral molecular dynamics simulations, it is demonstrated that the position of the proton in the intramolecular hydrogen bond of an aqueous hydrogen maleate anion is entirely related to the solvation pattern around the oxygen atoms of the intramolecular hydrogen bond. In particular, this anion has an asymmetric hydrogen bond, with the proton always located on the oxygen atom that is less solvated, owing to the instantaneous solvation environment. Simulations of water solutions of hydrogen maleate ion with two different counterions, K(+) and Na(+), surprisingly show that the intramolecular hydrogen-bond potential in the case of the Na(+) salt is always asymmetric, regardless of the hydrogen bonds to water, whereas for the K(+) salt, the potential for H motion depends on the location of the K(+). It is proposed that repulsion by the larger and more hydrated K(+) is weaker than that by Na(+) and competitive with solvation by water.

  7. Integrated microelectrode arrays for trace-metal analysis of aqueous solutions

    Energy Technology Data Exchange (ETDEWEB)

    Saban, S.B.; Darling, R.B. [Univ. of Washington, Seattle, WA (United States). Dept. of Electrical Engineering

    1995-12-31

    Stripping Voltammetry (SV) at microelectrodes has gained increased interest in the analysis of aqueous solutions due to its ability to analyze low concentrations (ppb) of electroactive metallic species in solution. Existing integrated circuit (IC) technology allows the inexpensive fabrication of microelectrodes with dimensions on the order of microns and with a high degree of uniformity and reproducibility. Additional circuitry, both multiplexing and signal conditioning, can be placed directly onto the sensor offering increased sensitivity and flexibility. Multi-element electrochemical sensors containing arrays of Pt, Au, and Ag electrodes and capable of individual measurement through built-in multiplexing or simultaneous measurement at the appropriate potential ranges for each individual electrode were fabricated using existing 2 micron IC technology. Results of simultaneous measurements of low concentrations of Cd, Pb, Cu, As, and Hg in solution indicate that interferences due to intermetallic compound formation at electrode surfaces can be isolated by the extra information provided by the differences in the formation of these compounds at different electrode surfaces.

  8. Utilising integrated urban water management to assess the viability of decentralised water solutions.

    Science.gov (United States)

    Burn, Stewart; Maheepala, Shiroma; Sharma, Ashok

    2012-01-01

    Cities worldwide are challenged by a number of urban water issues associated with climate change, population growth and the associated water scarcity, wastewater flows and stormwater run-off. To address these problems decentralised solutions are increasingly being considered by water authorities, and integrated urban water management (IUWM) has emerged as a potential solution to most of these urban water challenges, and as the key to providing solutions incorporating decentralised concepts at a city wide scale. To incorporate decentralised options, there is a need to understand their performance and their impact on a city's total water cycle under alternative water and land management options. This includes changes to flow, nutrient and sediment regimes, energy use, greenhouse gas emissions, and the impacts on rivers, aquifers and estuaries. Application of the IUWM approach to large cities demands revisiting the fundamental role of water system design in sustainable city development. This paper uses the extended urban metabolism model (EUMM) to expand a logical definition for the aims of IUWM, and discusses the role of decentralised systems in IUWM and how IUWM principles can be incorporated into urban water planning.

  9. Review of imaging solutions for integrated quantitative immunohistochemistry in the Pathology daily practice.

    Directory of Open Access Journals (Sweden)

    Marcial GarcĂ­a Rojo

    2010-02-01

    Full Text Available Immunohistochemistry (IHC plays an essential role in Pathology. In order to improve reproducibility and standardization of the results interpretation, IHC quantification methods have been developed. IHC interpretation based in whole slide imaging or virtual microscopy is of special interest. The objective of this work is to review the different computer-based programs for automatic immunohistochemistry and Fluorescence In Situ Hybridization (FISH evaluation. Scanning solutions and image analysis software in immunohistochemistry were studied, focusing especially on systems based in virtual slides. Integrated scanning and image analysis systems are available (Bacus TMAScore, Dako ACIS III, Genetix Ariol, Aperio Image Analysis, 3DHistech Mirax HistoQuant, Bioimagene Pathiam. Other image analysis software systems (Definiens TissueMap, SlidePath Tissue Image Analysis can be applied to several virtual slide formats. Fluorescence is the preferred approach in HistoRx AQUA, since it allows for a better compartmentalization of signals. Multispectral imaging using CRi Nuance allows multiple antibodies immunohistochemistry, and different stain unmixing. Most current popular automated image analysis solutions are aimed to brightfield immunohistochemistry, but fluorescence and FISH solutions may become more important in the near future. Automated quantitative tissue microarrays (TMA analysis is essential to provide high-throughput analysis. Medical informatics standards in images (DICOM and workflow (IHE under development will foster the use of image analysis in Pathology Departments.

  10. Integral transform solution of natural convection in a square cavity with volumetric heat generation

    Directory of Open Access Journals (Sweden)

    C. An

    2013-12-01

    Full Text Available The generalized integral transform technique (GITT is employed to obtain a hybrid numerical-analytical solution of natural convection in a cavity with volumetric heat generation. The hybrid nature of this approach allows for the establishment of benchmark results in the solution of non-linear partial differential equation systems, including the coupled set of heat and fluid flow equations that govern the steady natural convection problem under consideration. Through performing the GITT, the resulting transformed ODE system is then numerically solved by making use of the subroutine DBVPFD from the IMSL Library. Therefore, numerical results under user prescribed accuracy are obtained for different values of Rayleigh numbers, and the convergence behavior of the proposed eigenfunction expansions is illustrated. Critical comparisons against solutions produced by ANSYS CFX 12.0 are then conducted, which demonstrate excellent agreement. Several sets of reference results for natural convection with volumetric heat generation in a bi-dimensional square cavity are also provided for future verification of numerical results obtained by other researchers.

  11. Biomedical Engineering Laboratory

    Science.gov (United States)

    2007-11-02

    The Masters of Engineering program with concentration in Biomedical Engineering at Tennessee State University was established in fall 2000. Under... biomedical engineering . The lab is fully equipped with 10 Pentium5-based, 2 Pentium4-based laptops for mobile experiments at remote locations, 8 Biopac...students (prospective graduate students in biomedical engineering ) are regularly using this lab. This summer, 8 new prospective graduate students

  12. A Numerical Solution for One-dimensional Parabolic Equation Using Pseudo-spectral Integration Matrix and FDM

    Directory of Open Access Journals (Sweden)

    Saeid Gholami

    2014-01-01

    Full Text Available This study presents a numerical method for the solution of one type of PDEs equation. In this study, apply the pseudo-spectral successive integration method to approximate the solution of the one-dimensional parabolic equation. This method is based on El-Gendi pseudo-spectral method. Also the Finite Difference Method (FDM is used as a minor method. The present numerical results are in satisfactory agreement with exact solution.

  13. The 1D parabolic-parabolic Patlak-Keller-Segel model of chemotaxis: The particular integrable case and soliton solution

    Science.gov (United States)

    Shubina, Maria

    2016-09-01

    In this paper, we investigate the one-dimensional parabolic-parabolic Patlak-Keller-Segel model of chemotaxis. For the case when the diffusion coefficient of chemical substance is equal to two, in terms of travelling wave variables the reduced system appears integrable and allows the analytical solution. We obtain the exact soliton solutions, one of which is exactly the one-soliton solution of the Korteweg-de Vries equation.

  14. Fundamental of biomedical engineering

    CERN Document Server

    Sawhney, GS

    2007-01-01

    About the Book: A well set out textbook explains the fundamentals of biomedical engineering in the areas of biomechanics, biofluid flow, biomaterials, bioinstrumentation and use of computing in biomedical engineering. All these subjects form a basic part of an engineer''s education. The text is admirably suited to meet the needs of the students of mechanical engineering, opting for the elective of Biomedical Engineering. Coverage of bioinstrumentation, biomaterials and computing for biomedical engineers can meet the needs of the students of Electronic & Communication, Electronic & Instrumenta

  15. Searching for the (3+1)-Dimensional Painlevé Integrable Model and its Solitary Wave Solution

    Institute of Scientific and Technical Information of China (English)

    李画眉

    2002-01-01

    A (3+1)-dimensional integrable model constructed by conformal invariants is proven to be integrable. The solitary wave solution of the model is obtained by a simple algebraic transformation relation between the (3 + 1)-dimensional Harry-Dym equation and the cubic nonlinear Klein-Gordon equation.

  16. Evaluation of research in biomedical ontologies

    Science.gov (United States)

    Dumontier, Michel; Gkoutos, Georgios V.

    2013-01-01

    Ontologies are now pervasive in biomedicine, where they serve as a means to standardize terminology, to enable access to domain knowledge, to verify data consistency and to facilitate integrative analyses over heterogeneous biomedical data. For this purpose, research on biomedical ontologies applies theories and methods from diverse disciplines such as information management, knowledge representation, cognitive science, linguistics and philosophy. Depending on the desired applications in which ontologies are being applied, the evaluation of research in biomedical ontologies must follow different strategies. Here, we provide a classification of research problems in which ontologies are being applied, focusing on the use of ontologies in basic and translational research, and we demonstrate how research results in biomedical ontologies can be evaluated. The evaluation strategies depend on the desired application and measure the success of using an ontology for a particular biomedical problem. For many applications, the success can be quantified, thereby facilitating the objective evaluation and comparison of research in biomedical ontology. The objective, quantifiable comparison of research results based on scientific applications opens up the possibility for systematically improving the utility of ontologies in biomedical research. PMID:22962340

  17. Evaluation of research in biomedical ontologies.

    Science.gov (United States)

    Hoehndorf, Robert; Dumontier, Michel; Gkoutos, Georgios V

    2013-11-01

    Ontologies are now pervasive in biomedicine, where they serve as a means to standardize terminology, to enable access to domain knowledge, to verify data consistency and to facilitate integrative analyses over heterogeneous biomedical data. For this purpose, research on biomedical ontologies applies theories and methods from diverse disciplines such as information management, knowledge representation, cognitive science, linguistics and philosophy. Depending on the desired applications in which ontologies are being applied, the evaluation of research in biomedical ontologies must follow different strategies. Here, we provide a classification of research problems in which ontologies are being applied, focusing on the use of ontologies in basic and translational research, and we demonstrate how research results in biomedical ontologies can be evaluated. The evaluation strategies depend on the desired application and measure the success of using an ontology for a particular biomedical problem. For many applications, the success can be quantified, thereby facilitating the objective evaluation and comparison of research in biomedical ontology. The objective, quantifiable comparison of research results based on scientific applications opens up the possibility for systematically improving the utility of ontologies in biomedical research.

  18. Additive Manufacturing Integrated Energy—Enabling Innovative Solutions for Buildings of the Future

    Energy Technology Data Exchange (ETDEWEB)

    Biswas, Kaushik [Energy and Transportation Science Division,Oak Ridge National Laboratory,One Bethel Valley Road,Building 3147,P.O. Box 2008, M.S.—6070,Oak Ridge, TN 37831e-mail: biswask@ornl.gov; Rose, James [College of Architecture and Design,The University of Tennessee,Knoxville, TN 37996e-mail: jrose18@utk.edu; Eikevik, Leif [Skidmore, Owings & Merrill LLP,Chicago, IL 60604e-mail: leif.eikevik@som.com; Guerguis, Maged [Skidmore, Owings & Merrill LLP,Chicago, IL 60604e-mail: maged.guerguis@som.com; Enquist, Philip [Skidmore, Owings & Merrill LLP,Chicago, IL 60604,Governor' s Chair for Energy and Urbanism at theUniversity of Tennessee,Knoxville, TN 37996e-mail: Philip.Enquist@som.com; Lee, Brian [Skidmore, Owings & Merrill LLP,Chicago, IL 60604e-mail: Brian.Lee@som.com; Love, Lonnie [Energy and Transportation Science Division, Oak RidgeNational Laboratory,Oak Ridge, TN 37831e-mail: lovelj@ornl.gov; Green, Johney [Associate Laboratory Director at the National RenewableEnergy Laboratory,Golden, CO 80401e-mail: Johney.Green@nrel.gov; Jackson, Roderick [Energy and Transportation Science Division,Oak Ridge National Laboratory,Oak Ridge, TN 37831e-mail: jacksonrk@ornl.gov

    2016-11-10

    The additive manufacturing integrated energy (AMIE) demonstration utilized three-dimensional (3D) printing as an enabling technology in the pursuit of construction methods that use less material, create less waste, and require less energy to build and operate. Developed by Oak Ridge National Laboratory (ORNL) in collaboration with the Governor's Chair for Energy and Urbanism, a research partnership of the University of Tennessee (UT) and ORNL led by Skidmore, Owings & Merrill LLP (SOM), AMIE embodies a suite of innovations demonstrating a transformative future for designing, constructing, and operating buildings. Subsequent, independent UT College of Architecture and Design studios taught in collaboration with SOM professionals also explored forms and shapes based on biological systems that naturally integrate structure and enclosure. AMIE, a compact microdwelling developed by ORNL research scientists and SOM designers, incorporates next-generation modified atmosphere insulation (MAI), self-shading windows, and the ability to produce, store, and share solar power with a paired hybrid vehicle. It establishes for the first time, a platform for investigating solutions integrating the energy systems in buildings, vehicles, and the power grid. The project was built with broad-based support from local industry and national material suppliers. Designed and constructed in a span of only 9 months, AMIE 1.0 serves as an example of the rapid innovation that can be accomplished when research, design, academic, and industrial partners work in collaboration toward the common goal of a more sustainable and resilient built environment.

  19. Iterative solution of dense linear systems arising from the electrostatic integral equation in MEG

    Energy Technology Data Exchange (ETDEWEB)

    Rahola, Jussi [Simulintu Oy, Espoo (Finland); Tissari, Satu [CSC - Scientific Computing Ltd, Espoo (Finland)]. E-mail: satu.tissari@csc.fi

    2002-03-21

    We study the iterative solution of dense linear systems that arise from boundary element discretizations of the electrostatic integral equation in magnetoencephalography (MEG). We show that modern iterative methods can be used to decrease the total computation time by avoiding the time-consuming computation of the LU decomposition of the coefficient matrix. More importantly, the modern iterative methods make it possible to avoid the explicit formation of the coefficient matrix which is needed when a large number of unknowns are used. To study the convergence of iterative solvers we examine the eigenvalue distributions of the coefficient matrices. For the sphere we show how the eigenvalues of the integral operator are approximated by the eigenvalues of the coefficient matrix when the collocation and Galerkin methods are used as discretization methods. The collocation method approximates the eigenvalues of the integral operator directly. The Galerkin method produces a coefficient matrix that needs to be preconditioned in order to maintain optimal convergence speed. With the ILU(0) preconditioner iterative methods converge fast and independent of the number of discretization points for both the collocation and Galerkin approaches. The preconditioner has no significant effect on the total computational time. (author)

  20. SOLUTION MANAGMET’S TASK INTEGRATED SYSTEM OF UNMANNED AIRCRAFT IN CONDITIONS OF UNCERTAINITY

    Directory of Open Access Journals (Sweden)

    Anvar Hazarkhanov

    2011-03-01

    Full Text Available Abstract. In this article the methods of increase the efficiency of the compensation of indignations of theonboard integrated control systems of Unmanned Aircrafts are considered. On the basis of generalizationthe disadvantages of inertial and satellite navigation systems it was revealed, that as a result of theinsufficient compensation of indignations these systems lose a stable condition. They are exposed to barriersand there is unlimited growth of mistakes in time. For the solution of this actual problem of the onboardintegrated control systems a method of increase the efficiency of the compensation of indignations of nonstationarylinear systems in the conditions of uncertainty with the observer and with the correction bymistake of recovery was suggested. For this purpose the conditions of uncertainty were mathematicallystated, the equations of the onboard integrated control systems were completed, as non-stationary object ofmanagement, the observer with correction by mistake of recovery and a matrix of factor of strengthening ofthe observer are made. As a result the system is asymptotically stable to low-frequency indignations and theaccumulation of an error in time at high-frequency indignations is eliminated.Keywords: a condition of uncertainty, a matrix of factor of strengthening of the observer, iasymptoticalstability, low-frequency and high-frequency indignations, nertial and satellite navigation systems, nonstationarylinear systems, onboard integrated control systems, the observer with a correction by mistake ofrecovery, unmanned aircrafts.

  1. Relational Databases and Biomedical Big Data.

    Science.gov (United States)

    de Silva, N H Nisansa D

    2017-01-01

    In various biomedical applications that collect, handle, and manipulate data, the amounts of data tend to build up and venture into the range identified as bigdata. In such occurrences, a design decision has to be taken as to what type of database would be used to handle this data. More often than not, the default and classical solution to this in the biomedical domain according to past research is relational databases. While this used to be the norm for a long while, it is evident that there is a trend to move away from relational databases in favor of other types and paradigms of databases. However, it still has paramount importance to understand the interrelation that exists between biomedical big data and relational databases. This chapter will review the pros and cons of using relational databases to store biomedical big data that previous researches have discussed and used.

  2. Monitoring solute fluxes: Integrating electrical resistivity with multi-compartment sampler techniques

    Science.gov (United States)

    Bloem, Esther; Fernandez, Perrine; French, Helen K.

    2016-04-01

    The impact of agriculture, industry, airport activities on soil and water quality is strongly influenced by soil heterogeneity. To improve risk assessment, monitoring, and treatment strategies, we require a better understanding of the effect of soil heterogeneity on contaminant movement and better methods for monitoring heterogeneous contaminated transport. Sufficient characterization of spatial and temporal distribution of contaminant transport requires measurements of water and solute fluxes at multiple locations with a high temporal resolution. During this presentation, we will show a newly developed instrument, which combines multi-compartment sampling with electrical resistivity measurements, to observe spatial and temporal fluxes of contaminants. Solute monitoring is often limited to observations of resident concentrations, while flux concentrations govern the movement of solutes in soils. Bloem et al. (2010) developed a multi-compartment sampler (MCS) which is capable of measuring fluxes at a high spatial resolution under natural conditions. The sampler is divided into 100 separate compartments of 31 by 31 mm. Flux data can be recorded at a high time resolution (every 5 minutes). Tracer leaching can be monitored by frequently sampling the collected leachate while leaving the sampler buried in situ. To optimize the monitoring of tracer leaching and measure real solute fluxes the multi-compartment sampler has been extended with 121 electrodes. The electrodes are mounted at each corner of each compartment to measure the electrical conductivity above each compartment while water percolates through the compartments. By using different electrode couples, the setup can also be used to image above the multi-compartment sampler. The instrument can be used for detailed studies both in the laboratory and in the field. For laboratory experiments a transparent column is used which fits perfect on top of the MCS. We present a selection of the integrated electrical

  3. Monte Carlo solution of the volume-integral equation of electromagnetic scattering

    Science.gov (United States)

    Peltoniemi, J.; Muinonen, K.

    2014-07-01

    Electromagnetic scattering is often the main physical process to be understood when interpreting the observations of asteroids, comets, and meteors. Modeling the scattering faces still many problems, and one needs to assess several different cases: multiple scattering and shadowing by the rough surface, multiple scattering inside a surface element, and single scattering by a small object. Our specific goal is to extend the electromagnetic techniques to larger and more complicated objects, and derive approximations taking into account the most important effects of waves. Here we experiment with Monte Carlo techniques: can they provide something new to solving the scattering problems? The electromagnetic wave equation in the presence of a scatterer of volume V and refractive index m, with an incident wave EE_0, including boundary conditions and the scattering condition at infinity, can be presented in the form of an integral equation EE(rr)(1+suski(rr) Q(ρ))-int_{V-V_ρ}ddrr' GG(rr-rr')suski(rr')EE(rr') =EE_0, where suski(rr)=m(rr)^2-1, Q(ρ)=-1/3+{cal O}(ρ^2)+{O'}(m^2ρ^2), {O}, and {O'} are some second- and higher-order corrections for the finite-size volume V_ρ of radius ρ around the singularity and GG is the dyadic Green's function of the form GG(RR)={exp(im kR)}/{4π R}[unittensor(1+{im}/{R}-{1}/{R^2})-RRRR(1+{3im}/{R}-{3}/{R^2})]. In general, this is solved by extending the internal field in terms of some simple basis functions, e.g., plane or spherical waves or a cubic grid, approximating the integrals in a clever way, and determining the goodness of the solution somehow, e.g., moments or least square. Whatever the choice, the solution usually converges nicely towards a correct enough solution when the scatterer is small and simple, and diverges when the scatterer becomes too complicated. With certain methods, one can reach larger scatterers faster, but the memory and CPU needs can be huge. Until today, all successful solutions are based on more or less

  4. Advances in numerical solutions to integral equations in liquid state theory

    Science.gov (United States)

    Howard, Jesse J.

    Solvent effects play a vital role in the accurate description of the free energy profile for solution phase chemical and structural processes. The inclusion of solvent effects in any meaningful theoretical model however, has proven to be a formidable task. Generally, methods involving Poisson-Boltzmann (PB) theory and molecular dynamic (MD) simulations are used, but they either fail to accurately describe the solvent effects or require an exhaustive computation effort to overcome sampling problems. An alternative to these methods are the integral equations (IEs) of liquid state theory which have become more widely applicable due to recent advancements in the theory of interaction site fluids and the numerical methods to solve the equations. In this work a new numerical method is developed based on a Newton-type scheme coupled with Picard/MDIIS routines. To extend the range of these numerical methods to large-scale data systems, the size of the Jacobian is reduced using basis functions, and the Newton steps are calculated using a GMRes solver. The method is then applied to calculate solutions to the 3D reference interaction site model (RISM) IEs of statistical mechanics, which are derived from first principles, for a solute model of a pair of parallel graphene plates at various separations in pure water. The 3D IEs are then extended to electrostatic models using an exact treatment of the long-range Coulomb interactions for negatively charged walls and DNA duplexes in aqueous electrolyte solutions to calculate the density profiles and solution thermodynamics. It is found that the 3D-IEs provide a qualitative description of the density distributions of the solvent species when compared to MD results, but at a much reduced computational effort in comparison to MD simulations. The thermodynamics of the solvated systems are also qualitatively reproduced by the IE results. The findings of this work show the IEs to be a valuable tool for the study and prediction of

  5. 5th International Conference on Biomedical Engineering in Vietnam

    CERN Document Server

    Phuong, Tran

    2015-01-01

    This volume presents the proceedings of the Fifth International Conference on the Development of Biomedical Engineering in Vietnam which was held from June 16-18, 2014 in Ho Chi Minh City. The volume reflects the progress of Biomedical Engineering and discusses problems and solutions. I aims identifying new challenges, and shaping future directions for research in biomedical engineering fields including medical instrumentation, bioinformatics, biomechanics, medical imaging, drug delivery therapy, regenerative medicine and entrepreneurship in medical devices.

  6. Deproteinization: an integrated-solution approach to increase efficiency in β-galactosidase production using cheese whey powder (CWP solution

    Directory of Open Access Journals (Sweden)

    Leandro Freire dos Santos

    2017-08-01

    Full Text Available Whey is the liquid that results from the coagulation of milk during cheese manufacture. Cheese whey is also an important environmental pollution source. The present experiment sought to compare β-galactosidase (EC 3.2.1.23 production by Aspergillus oryzae from deproteinized and un-deproteinized CWP solutions. β-galactosidase was produced by submerged fermentation in deproteinized or un-deproteinized CWP solutions. To determine the activity of the enzyme, a reaction mixture containing cell-free extract and ortho Nitrophenyl β galactoside (ONPG was used. The results indicated that β-galactosidase induction was greater when using deproteinized CWP solution compared to the un deproteinized CWP solution. These results may enable an alternative management of cheese whey, thereby decreasing its impact on the environment and producing value-added biomacromolecules.

  7. Dynamic response of axially moving Timoshenko beams:integral transform solution

    Institute of Scientific and Technical Information of China (English)

    安晨; 苏健

    2014-01-01

    The generalized integral transform technique (GITT) is used to find a semi-analytical numerical solution for dynamic response of an axially moving Timoshenko beam with clamped-clamped and simply-supported boundary conditions, respectively. The im-plementation of GITT approach for analyzing the forced vibration equation eliminates the space variable and leads to systems of second-order ordinary differential equations (ODEs) in time. The MATHEMATICA built-in function, NDSolve, is used to numeri-cally solve the resulting transformed ODE system. The good convergence behavior of the suggested eigenfunction expansions is demonstrated for calculating the transverse deflec-tion and the angle of rotation of the beam cross-section. Moreover, parametric studies are performed to analyze the effects of the axially moving speed, the axial tension, and the amplitude of external distributed force on the vibration amplitude of axially moving Timoshenko beams.

  8. DIMP: an interoperable solution for software integration and product data exchange

    Science.gov (United States)

    Wang, Xi Vincent; Xu, Xun William

    2012-08-01

    Today, globalisation has become one of the main trends of manufacturing business that has led to a world-wide decentralisation of resources amongst not only individual departments within one company but also business partners. However, despite the development and improvement in the last few decades, difficulties in information exchange and sharing still exist in heterogeneous applications environments. This article is divided into two parts. In the first part, related research work and integrating solutions are reviewed and discussed. The second part introduces a collaborative environment called distributed interoperable manufacturing platform, which is based on a module-based, service-oriented architecture (SOA). In the platform, the STEP-NC data model is used to facilitate data-exchange among heterogeneous CAD/CAM/CNC systems.

  9. PATH INTEGRAL SOLUTION OF NONLINEAR DYNAMIC BEHAVIOR OF STRUCTURE UNDER WIND EXCITATION

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    A numerical scheme for the nonlinear behavior of structure under wind excitation is investigated. With the white noise filter of turbulent-wind fluctuations, the nonlinear motion equation of structures subjected to wind load was modeled as the Ito' s stochastic differential equation. The state vector associated with such a model is a diffusion process. A continuous linearization strategy in the time-domain was adopted.Based on the solution series of its stochastic linearization equations, the formal probabilistic density of the structure response was developed by the path integral technique. It is shown by the numerical example of a guyed mast that compared with the frequency-domain method and the time-domain nonlinear analysis, the proposed approach is highlighted by high accuracy and effectiveness. The influence of the structure non-linearity on the dynamic reliability assessment is also analyzed in the example.

  10. Effects of Dissolving Solutions on the Accuracy of an Electronic Apex Locator-Integrated Endodontic Handpiece

    Science.gov (United States)

    Ustun, Yakup; Uzun, Ozgur; Er, Ozgur; Maden, Murat; Yalpı, Fatma; Canakci, Burhan Can

    2013-01-01

    The effects of three dissolving agents on the accuracy of an electronic apex locator- (EAL-) integrated endodontic handpiece during retreatment procedures were evaluated. The true lengths (TLs) of 56 extracted incisor teeth were determined visually. Twenty teeth were filled with gutta-percha and a resin-based sealer (group A), 20 with gutta-percha and a zinc oxide/eugenol-based sealer (group B), and 16 roots were used as the control group (group C). All roots were prepared to TL. Guttasolv, Resosolv, and Endosolv E were used as the dissolving solutions. Two evaluations of the handpiece were performed: the apical accuracy during the auto reverse function (ARL) and the apex locator function (EL) alone. The ARL function of the handpiece gave acceptable results. There were significant differences between the EL mode measurements and the TL (P < 0.05). In these comparisons, Tri Auto ZX EL mode measurements were significantly shorter than those of the TL. PMID:24379743

  11. Optimizing biomedical science learning in a veterinary curriculum: a review.

    Science.gov (United States)

    Warren, Amy L; Donnon, Tyrone

    2013-01-01

    As veterinary medical curricula evolve, the time dedicated to biomedical science teaching, as well as the role of biomedical science knowledge in veterinary education, has been scrutinized. Aside from being mandated by accrediting bodies, biomedical science knowledge plays an important role in developing clinical, diagnostic, and therapeutic reasoning skills in the application of clinical skills, in supporting evidence-based veterinary practice and life-long learning, and in advancing biomedical knowledge and comparative medicine. With an increasing volume and fast pace of change in biomedical knowledge, as well as increased demands on curricular time, there has been pressure to make biomedical science education efficient and relevant for veterinary medicine. This has lead to a shift in biomedical education from fact-based, teacher-centered and discipline-based teaching to applicable, student-centered, integrated teaching. This movement is supported by adult learning theories and is thought to enhance students' transference of biomedical science into their clinical practice. The importance of biomedical science in veterinary education and the theories of biomedical science learning will be discussed in this article. In addition, we will explore current advances in biomedical teaching methodologies that are aimed to maximize knowledge retention and application for clinical veterinary training and practice.

  12. Identifying Key Issues and Potential Solutions for Integrated Arrival, Departure, Surface Operations by Surveying Stakeholder Preferences

    Science.gov (United States)

    Aponso, Bimal; Coppenbarger, Richard A.; Jung, Yoon; Quon, Leighton; Lohr, Gary; O’Connor, Neil; Engelland, Shawn

    2015-01-01

    NASA's Aeronautics Research Mission Directorate (ARMD) collaborates with the FAA and industry to provide concepts and technologies that enhance the transition to the next-generation air-traffic management system (NextGen). To facilitate this collaboration, ARMD has a series of Airspace Technology Demonstration (ATD) sub-projects that develop, demonstrate, and transitions NASA technologies and concepts for implementation in the National Airspace System (NAS). The second of these sub-projects, ATD-2, is focused on the potential benefits to NAS stakeholders of integrated arrival, departure, surface (IADS) operations. To determine the project objectives and assess the benefits of a potential solution, NASA surveyed NAS stakeholders to understand the existing issues in arrival, departure, and surface operations, and the perceived benefits of better integrating these operations. NASA surveyed a broad cross-section of stakeholders representing the airlines, airports, air-navigation service providers, and industry providers of NAS tools. The survey indicated that improving the predictability of flight times (schedules) could improve efficiency in arrival, departure, and surface operations. Stakeholders also mentioned the need for better strategic and tactical information on traffic constraints as well as better information sharing and a coupled collaborative planning process that allows stakeholders to coordinate IADS operations. To assess the impact of a potential solution, NASA sketched an initial departure scheduling concept and assessed its viability by surveying a select group of stakeholders for a second time. The objective of the departure scheduler was to enable flights to move continuously from gate to cruise with minimal interruption in a busy metroplex airspace environment using strategic and tactical scheduling enhanced by collaborative planning between airlines and service providers. The stakeholders agreed that this departure concept could improve schedule

  13. Comparison and Combination of Solutions From the Southern California Integrated GPS Network

    Science.gov (United States)

    King, N. E.; Hurst, K.; Langbein, J.; van Domselaar, M.

    2001-12-01

    The Southern California Integrated GPS Network (SCIGN) has two independent centers for precise processing of data from 250 stations. The Jet Propulsion Laboratory (JPL) uses the processing software GIPSY-OASIS-II, and the Scripps Institution of Oceanography (SIO) uses the GAMIT/GLOBK/GLORG software. In earlier comparisons of JPL and SIO results, we found discrepancies of several mm in station position and several mm/yr in station velocity and traced these differences to inconsistent antenna heights, different methods of time series analysis, and different reference frames. Current work focussed on correcting antenna heights, comparing baselines, investigating noise models and offset detection, and defining a common reference frame in which to combine JPL and SIO solutions. For baselines, which are relative positions between two stations and hence do not depend on reference frame, the mean difference in JPL and SIO relative position is about 0.1 mm in the horizontal and 0.5 mm in the vertical. Proportional error in baselines is 0.9, 2.5, and 1.0 parts per billion (ppb) for the north, east, and vertical components, respectively, and 1.2 ppb for baseline length. Offset detection and estimation depends on the error model; the best current noise model is a combination of white and flicker noise. Estimated offset uncertainties are then 0.5 mm in the north, 1 mm in the east, and 2 mm in the vertical. To combine JPL and SIO solutions, we defined a preliminary SCIGN reference frame by choosing 16 stations with good geographic distribution and a fairly complete time history back to 1996. The JPL and SIO groups reprocessed data from these stations with loose constraints on station coordinates. We used GLOBK/GLORG to combine the JPL and SIO daily solution and covariance files, aligning to the IGS97 positions of the global stations. These results provide a reference frame (SCIGN97 v.1.) for the entire SCIGN array. For data back to 1996, the mean difference between JPL and SIO

  14. Integrated subsurface water solutions for coastal environments through integrated pump&treat and aquifer storage and recovery (ASR) schemes

    Science.gov (United States)

    Perdikaki, Martha; Kallioras, Andreas; Christoforidis, Christophoros; Iossifidis, Dimitris; Zafeiropoulos, Anastasios; Dimitriadis, Klisthenis; Makropoulos, Christos; Raat, Klaasjan; van den Berg, Gerard

    2016-04-01

    Coastal wetlands in semi-arid regions, as in Circum-Mediterranean, are considered important ecosystems that provide valuable services to human population and the environment, such as: flood protection, erosion control, wildlife habitat, water quality, recreation and carbon sequestration. Un-managed surface and groundwater exploitation in these areas usually leads to deterioration of such sensitive ecosystems by means of water resources degradation and/or increased salinity. Groundwater usually plays a vital role for the sustainability of these hydrological systems, as the underlying aquifers operate as regulators for both quantity and quality of their waters. Multi-layer and multi-objective Managed Aquifer Recharge (MAR) systems can be proved effective groundwater engineered solutions for the restoration of deteriorated coastal wetlands in semi- and arid regions. The plain of Marathon is a typical Mediterranean environment that hosts a naturally occurring -and today degraded- coastal wetland with the characteristics of a distinct ecosystem linked to a typical coastal hydrogeological system of a semi-arid region; and therefore can serve as a model for similar systems world-wide. The geo-hydrological setting of the area involves a multi-layer aquifer system consisting of (i) an upper un-consolidated formation of depositional unit dominated mostly by fluvial sediments and (ii) the surrounding and underlying karstified marbles; both being linked to the investigated wetland and also subjected to seawater encroachment. A smart engineered MAR system via an optimised Pump & Treat system integrated with an Aquifer Storage and Recovery (ASR) scheme in this area would include the abstraction of brackish groundwater from the deeper karst aquifer at a location close to the shoreline and direct treatment with Reverse Osmosis (RO). for desalination. Two-fold re-use scheme of the purified effluent can then be engineered for (i) the restoration of the coastal wetland; and (ii

  15. A note on analytical solutions of nonlinear fractional 2D heat equation with non-local integral terms

    Indian Academy of Sciences (India)

    O S IYIOLA; F D ZAMAN

    2016-10-01

    In this paper, we consider the (2+1) nonlinear fractional heat equation with non-local integral terms and investigate two different cases of such non-local integral terms. The first has to do with the time-dependent non-local integral term and the second is the space-dependent non-local integral term. Apart from the nonlinear nature of these formulations, the complexity due to the presence of the non-local integral terms impelled us to use a relatively new analytical technique called q-homotopy analysis method to obtain analytical solutions to both cases in the form of convergent series with easily computable components. Our numerical analysis enables us to show the effects of non-local terms and the fractional-order derivative on the solutions obtained by this method.

  16. Data Security, Privacy, Availability and Integrity in Cloud Computing: Issues and Current Solutions

    Directory of Open Access Journals (Sweden)

    Sultan Aldossary

    2016-04-01

    Full Text Available Cloud computing changed the world around us. Now people are moving their data to the cloud since data is getting bigger and needs to be accessible from many devices. Therefore, storing the data on the cloud becomes a norm. However, there are many issues that counter data stored in the cloud starting from virtual machine which is the mean to share resources in cloud and ending on cloud storage itself issues. In this paper, we present those issues that are preventing people from adopting the cloud and give a survey on solutions that have been done to minimize risks of these issues. For example, the data stored in the cloud needs to be confidential, preserving integrity and available. Moreover, sharing the data stored in the cloud among many users is still an issue since the cloud service provider is untrustworthy to manage authentication and authorization. In this paper, we list issues related to data stored in cloud storage and solutions to those issues which differ from other papers which focus on cloud as general.

  17. Robust automatic detection and removal of fiducial projections in fluoroscopy images: an integrated solution.

    Science.gov (United States)

    Zhang, Xuan; Zheng, Guoyan

    2008-01-01

    Automatic detection and removal of fiducial projections in fluoroscopy images is an essential prerequisite for fluoroscopy-based navigation and image-based 3D-2D registration. This paper presents an integrated solution to fulfill this task. A custom-designed calibration cage with a two-plane pattern of fiducials is utilized in our solution. The cage is attached to the C-arm image intensifier and the projections of the fiducials are automatically detected and removed by an on-line algorithm consisting of following 6 steps: image binarization, connected-component labeling, region classification, adaptive template matching, shape analysis, and fiducial projection removal. A similarity measure which is proposed previously for image-based 3D-2D registration is employed in the adaptive template matching to improve the accuracy of the detection. Shape analysis based on the geometrical constraints satisfied by those fiducials in the calibration cage is used to further improve the robustness of the detection. An image inpainting technique based on the fast marching method for level set applications is used to remove the detected fiducial projections. Our in vitro experiments show on average 4 seconds execution time on a Pentium IV machine, a zero false-detection rate, a miss-detection rate of 1.6+/-2.3%, and a sub-pixel localization error.

  18. Neural Network-Based Solutions for Stochastic Optimal Control Using Path Integrals.

    Science.gov (United States)

    Rajagopal, Karthikeyan; Balakrishnan, Sivasubramanya Nadar; Busemeyer, Jerome R

    2017-03-01

    In this paper, an offline approximate dynamic programming approach using neural networks is proposed for solving a class of finite horizon stochastic optimal control problems. There are two approaches available in the literature, one based on stochastic maximum principle (SMP) formalism and the other based on solving the stochastic Hamilton-Jacobi-Bellman (HJB) equation. However, in the presence of noise, the SMP formalism becomes complex and results in having to solve a couple of backward stochastic differential equations. Hence, current solution methodologies typically ignore the noise effect. On the other hand, the inclusion of noise in the HJB framework is very straightforward. Furthermore, the stochastic HJB equation of a control-affine nonlinear stochastic system with a quadratic control cost function and an arbitrary state cost function can be formulated as a path integral (PI) problem. However, due to curse of dimensionality, it might not be possible to utilize the PI formulation for obtaining comprehensive solutions over the entire operating domain. A neural network structure called the adaptive critic design paradigm is used to effectively handle this difficulty. In this paper, a novel adaptive critic approach using the PI formulation is proposed for solving stochastic optimal control problems. The potential of the algorithm is demonstrated through simulation results from a couple of benchmark problems.

  19. APPLYING AN INTEGRATED ROUTE OPTIMIZATION METHOD AS A SOLUTION TO THE PROBLEM OF WASTE COLLECTION

    Directory of Open Access Journals (Sweden)

    A. H. Salleh

    2016-09-01

    Full Text Available Solid waste management (SWM is very subjective to budget control where the utmost expenses are devoted to the waste collection’s travel route. The common understanding of the travel route in SWM is that shorter route is cheaper. However, in reality it is not necessarily true as the SWM compactor truck is affected by various aspects which leads to higher fuel consumption. Thus, this ongoing research introduces a solution to the problem using multiple criteria route optimization process integrated with AHP/GIS as its main analysis tools. With the criteria obtained from the idea that leads to higher fuel consumption based on road factors, road networks and human factors. The weightage of criteria is obtained from the combination of AHP with the distance of multiple shortest routes obtained from GIS. A solution of most optimum routes is achievable and comparative analysis with the currently used route by the SWM compactor truck can be compared. It is expected that the decision model will be able to solve the global and local travel route problem in MSW.

  20. Applying AN Integrated Route Optimization Method as a Solution to the Problem of Waste Collection

    Science.gov (United States)

    Salleh, A. H.; Ahamad, M. S. S.; Yusoff, M. S.

    2016-09-01

    Solid waste management (SWM) is very subjective to budget control where the utmost expenses are devoted to the waste collection's travel route. The common understanding of the travel route in SWM is that shorter route is cheaper. However, in reality it is not necessarily true as the SWM compactor truck is affected by various aspects which leads to higher fuel consumption. Thus, this ongoing research introduces a solution to the problem using multiple criteria route optimization process integrated with AHP/GIS as its main analysis tools. With the criteria obtained from the idea that leads to higher fuel consumption based on road factors, road networks and human factors. The weightage of criteria is obtained from the combination of AHP with the distance of multiple shortest routes obtained from GIS. A solution of most optimum routes is achievable and comparative analysis with the currently used route by the SWM compactor truck can be compared. It is expected that the decision model will be able to solve the global and local travel route problem in MSW.

  1. An Integrated Numerical Hydrodynamic Shallow Flow-Solute Transport Model for Urban Area

    Science.gov (United States)

    Alias, N. A.; Mohd Sidek, L.

    2016-03-01

    The rapidly changing on land profiles in the some urban areas in Malaysia led to the increasing of flood risk. Extensive developments on densely populated area and urbanization worsen the flood scenario. An early warning system is really important and the popular method is by numerically simulating the river and flood flows. There are lots of two-dimensional (2D) flood model predicting the flood level but in some circumstances, still it is difficult to resolve the river reach in a 2D manner. A systematic early warning system requires a precisely prediction of flow depth. Hence a reliable one-dimensional (1D) model that provides accurate description of the flow is essential. Research also aims to resolve some of raised issues such as the fate of pollutant in river reach by developing the integrated hydrodynamic shallow flow-solute transport model. Presented in this paper are results on flow prediction for Sungai Penchala and the convection-diffusion of solute transports simulated by the developed model.

  2. Integral transform solutions of dynamic response of a clamped-clamped pipe conveying fluid

    Energy Technology Data Exchange (ETDEWEB)

    Gu Jijun; An Chen [Ocean Engineering Program, COPPE, Universidade Federal do Rio de Janeiro, CP 68508, Rio de Janeiro 21941-972 (Brazil); Duan Menglan [Offshore Oil/Gas Research Center, China University of Petroleum, Beijing 102249 (China); Levi, Carlos [Ocean Engineering Program, COPPE, Universidade Federal do Rio de Janeiro, CP 68508, Rio de Janeiro 21941-972 (Brazil); Su Jian, E-mail: sujian@nuclear.ufrj.br [Nuclear Engineering Program, COPPE, Universidade Federal do Rio de Janeiro, CP 68509, Rio de Janeiro 21941-972 (Brazil)

    2013-01-15

    Highlights: Black-Right-Pointing-Pointer Dynamic response of pipe conveying fluid was studied numerically. Black-Right-Pointing-Pointer The generalized integral transform technique (GITT) was applied. Black-Right-Pointing-Pointer Numerical solutions with automatic global accuracy control were obtained. Black-Right-Pointing-Pointer Excellent convergence behavior was shown. Black-Right-Pointing-Pointer Modal separation analysis was carried out and the influence of mass ratio was analyzed. - Abstract: Analysis of dynamic response of pipe conveying fluid is an important aspect in nuclear power plant design. In the present paper, dynamic response of a clamped-clamped pipe conveying fluid was solved by the generalized integral transform technique (GITT). The governing partial differential equation was transformed into a set of second-order ordinary differential equations which is then numerically solved by making use of the subroutine DIVPAG from IMSL Library. A thorough convergence analysis was performed to yield sets of reference results of the transverse deflection at different time and spanwise position. We found good agreement between the computed natural frequencies at mode 1-3 and those obtained by previous theoretical study. Besides, modal separation analysis was carried out and the influence of mass ratio on deflection and natural frequencies was qualitatively and quantitatively assessed.

  3. Solution of fractional kinetic equation by a class of integral transform of pathway type

    Science.gov (United States)

    Kumar, Dilip

    2013-04-01

    Solutions of fractional kinetic equations are obtained through an integral transform named Pα-transform introduced in this paper. The Pα-transform is a binomial type transform containing many class of transforms including the well known Laplace transform. The paper is motivated by the idea of pathway model introduced by Mathai [Linear Algebra Appl. 396, 317-328 (2005), 10.1016/j.laa.2004.09.022]. The composition of the transform with differential and integral operators are proved along with convolution theorem. As an illustration of applications to the general theory of differential equations, a simple differential equation is solved by the new transform. Being a new transform, the Pα-transform of some elementary functions as well as some generalized special functions such as H-function, G-function, Wright generalized hypergeometric function, generalized hypergeometric function, and Mittag-Leffler function are also obtained. The results for the classical Laplace transform is retrieved by letting α → 1.

  4. Integrated Modeling of Solutions in the System of Distributing Logistics of a Fruit and Vegetable Cooperative

    Directory of Open Access Journals (Sweden)

    Oleksandr Velychko

    2014-12-01

    Full Text Available A mechanism of preparing rationalistic solutions in the system of distributing logistics of a fruit and vegetable cooperative has been studied considering possible alternatives and existing limitations. Belonging of separate operations of the fruit and vegetable cooperative to technological, logistical or marketing business processes has been identified. Expediency of the integrated use of logistical concept DRP, decision tree method and linear programming in management of the cooperative has been grounded. The model for preparing decisions on organizing sales of vegetables and fruit which is focused on minimization of costs of cooperative services and maximization of profits for members of the cooperation has been developed. The necessity to consider integrated model of differentiation on levels of post gathering processing and logistical service has been revealed. Methodology of representation in the economical-mathematical model of probabilities in the tree of decisions concerning the expected amount of sales and margin for members of the cooperative using different channels has been processed. A formula which enables scientists to describe limitations in linear programming concerning critical duration of providing harvest of vegetables and fruit after gathering towards a customer has been suggested.

  5. Scientific Research for Integrated Solutions to Community Challenges: The Thriving Earth Exchange (TEX) Approach

    Science.gov (United States)

    Udu-gama, N.; Pandya, R.

    2015-12-01

    There is tremendous unmet and sometimes unrealized need for Earth and space science (ESS) expertise as part of civic decisions and local planning for climate change, natural hazards and natural resources. The Thriving Earth Exchange (TEX) helps AGU contribute that expertise to humanity in respectful, integrated ways. TEX brings ESS scientists together with local communities tackling issues of climate change, natural hazards and natural resources to co-design solutions that equitably integrate both scientific and community knowledge. To achieve this ambitious goal, TEX is partnering with organizations that are respected by and knowledgeable about communities both in the United States and internationally. Such partnerships include Rockefeller's 100 Resilient Cities Initiative, ICLEI USA, MIT's Climate Colab, among others. TEX works with these partners to approach communities who are ready to or already addressing ESS related issues. With partners, we help the communities define their goals, develop specific projects, and connect with relevant and helpful ESS scientists. We will also show how we help scientists and community leaders work productively together, and the tools we bring to support their innovation. It will highlight international examples, such as in the Pamir Mountains of Afghanistan-Tajikistan, Sri Lanka, and Ethiopia, and provide concrete examples of how these initiatives are helping TEX further expand the frontiers of collaborative research.

  6. Barriers and potential solutions for Critical Zone data integration between environmental genomics and the geosciences

    Science.gov (United States)

    Aronson, E. L.; Meyer, F.; Packman, A. I.; Mayorga, E.

    2015-12-01

    The Earth's permeable near-surface layer from bedrock to canopy is referred to as the Critical Zone (CZ). Integration of bio- and geoscience data is critical for understanding physical, biological and chemical interactions in the CZ. Genomic and meta-genomic scientists study organisms both in laboratory settings and in the environment, in order to understand the interactions of organisms with the environment. Geoscientists are using environmental data to describe and model dynamics of physical and chemical properties. Yet, there is no agreed upon method for integrating genomic and environmental data to address interactions of living and non-living components of the CZ. There are standards for data interchange being developed in the geosciences and genomics sciences, via standards organization such as the Open Geospatial Consortium (OGC), as well as by research communities in biogeochemistry, hydrology, climatology, and other fields. These are in parallel to, but typically not in coordination with the standards the Genomics Standards Consortium (GSC) is developing for genomics. In addition, efforts are being made to allow for intercompatability of these CZ data with data generated by NEON, Inc. The interoperability of these types of data is limited with current software and cyberinfrastructure. A group of CZ geoscientists, environmental genomic scientists and cyberinfrastructure scientists are coming together to develop a set of common data collection and integration methods and sets of common standards. The data generated by this effort across multiple CZ sites (including the US CZ Observatories, or CZOs) around the world, along with NEON facility data, will be used to test EarthCube (an NSF initiative to develop cyberinfrastructure for the geosciences) cyberinfrastructure, with the goal of bridging this gap in standards and interoperability. Potential solutions to these issues of interoperability will be presented, and a way forward will be described.

  7. Magnetic microfluidic platform for biomedical applications using magnetic nanoparticles

    KAUST Repository

    Stipsitz, Martin

    2015-05-01

    Microfluidic platforms are well-suited for biomedical analysis and usually consist of a set of units which guarantee the manipulation, detection and recognition of bioanalyte in a reliable and flexible manner. Additionally, the use of magnetic fields for perfoming the aforementioned tasks has been steadily gainining interest. This is due to the fact that magnetic fields can be well tuned and applied either externally or from a directly integrated solution in the diagnostic system. In combination with these applied magnetic fields, magnetic nanoparticles are used. In this paper, we present some of our most recent results in research towards a) microfluidic diagnostics using MR sensors and magnetic particles and b) single cell analysis using magnetic particles. We have successfully manipulated magnetically labeled bacteria and measured their response with integrated GMR sensors and we have also managed to separate magnetically labeled jurkat cells for single cell analysis. © 2015 Trans Tech Publications, Switzerland.

  8. An integrative solution for managing, tracing and citing sensor-related information

    Science.gov (United States)

    Koppe, Roland; Gerchow, Peter; Macario, Ana; Schewe, Ingo; Rehmcke, Steven; Düde, Tobias

    2017-04-01

    In a data-driven scientific world, the need to capture information on sensors used in the data acquisition process has become increasingly important. Following the recommendations of the Open Geospatial Consortium (OGC), we started by adopting the SensorML standard for describing platforms, devices and sensors. However, it soon became obvious to us that understanding, implementing and filling such standards costs significant effort and cannot be expected from every scientist individually. So we developed a web-based sensor management solution (https://sensor.awi.de) for describing platforms, devices and sensors as hierarchy of systems which supports tracing changes to a system whereas hiding complexity. Each platform contains devices where each device can have sensors associated with specific identifiers, contacts, events, related online resources (e.g. manufacturer factsheets, calibration documentation, data processing documentation), sensor output parameters and geo-location. In order to better understand and address real world requirements, we have closely interacted with field-going scientists in the context of the key national infrastructure project "FRontiers in Arctic marine Monitoring ocean observatory" (FRAM) during the software development. We learned that not only the lineage of observations is crucial for scientists but also alert services using value ranges, flexible output formats and information on data providers (e.g. FTP sources) for example. Mostly important, persistent and citable versions of sensor descriptions are required for traceability and reproducibility allowing seamless integration with existing information systems, e.g. PANGAEA. Within the context of the EU-funded Ocean Data Interoperability Platform project (ODIP II) and in cooperation with 52north we are proving near real-time data via Sensor Observation Services (SOS) along with sensor descriptions based on our sensor management solution. ODIP II also aims to develop a harmonized

  9. MANAGEMENT OF SOLID WASTE GENERATED BY THE INTEGRATED STEELWORKS ACTIVITY AND SOLUTIONS TO REDUCE THE ENVIRONMENTAL IMPACT

    Directory of Open Access Journals (Sweden)

    Anişoara CIOCAN

    2010-05-01

    Full Text Available The development of steel industry is subject to solve major problems arising from industry-nature relationship, strictly targeted on pollution control and protection of natural resources and energy. In this paper we discussed about the management of solid waste generated by an integrated steelwork located near a major urban area and the adopted solutions for the reduction of environmental impact. There are summarized technical solutions that are currently applied and were proposed some solutions that can be applied in accordance with the environmental legislations. The new solutions are proposed for integrated management of solid wastes in accordance with: the exact quantification (quantitative, qualitative and the generation sources of emissions and solid wastes; controlled storage; minimization of the wastes and its harmfulness; transformation of the wastes into valuable by-products used directly by the company in a subsequent process, or by external down-stream user.

  10. Handbook of biomedical optics

    CERN Document Server

    Boas, David A

    2011-01-01

    Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamentals of each subject, ensuring accessibility to a wide multidisciplinary readership. It also offers a view of the state of the art and discusses advantages and disadvantages of various techniques.Organized into six sections, this handbook: Contains intr

  11. Biomedical applications of polymers

    CERN Document Server

    Gebelein, C G

    1991-01-01

    The biomedical applications of polymers span an extremely wide spectrum of uses, including artificial organs, skin and soft tissue replacements, orthopaedic applications, dental applications, and controlled release of medications. No single, short review can possibly cover all these items in detail, and dozens of books andhundreds of reviews exist on biomedical polymers. Only a few relatively recent examples will be cited here;additional reviews are listed under most of the major topics in this book. We will consider each of the majorclassifications of biomedical polymers to some extent, inclu

  12. Powering biomedical devices

    CERN Document Server

    Romero, Edwar

    2013-01-01

    From exoskeletons to neural implants, biomedical devices are no less than life-changing. Compact and constant power sources are necessary to keep these devices running efficiently. Edwar Romero's Powering Biomedical Devices reviews the background, current technologies, and possible future developments of these power sources, examining not only the types of biomedical power sources available (macro, mini, MEMS, and nano), but also what they power (such as prostheses, insulin pumps, and muscular and neural stimulators), and how they work (covering batteries, biofluids, kinetic and ther

  13. Biomedical Engineering Desk Reference

    CERN Document Server

    Ratner, Buddy D; Schoen, Frederick J; Lemons, Jack E; Dyro, Joseph; Martinsen, Orjan G; Kyle, Richard; Preim, Bernhard; Bartz, Dirk; Grimnes, Sverre; Vallero, Daniel; Semmlow, John; Murray, W Bosseau; Perez, Reinaldo; Bankman, Isaac; Dunn, Stanley; Ikada, Yoshito; Moghe, Prabhas V; Constantinides, Alkis

    2009-01-01

    A one-stop Desk Reference, for Biomedical Engineers involved in the ever expanding and very fast moving area; this is a book that will not gather dust on the shelf. It brings together the essential professional reference content from leading international contributors in the biomedical engineering field. Material covers a broad range of topics including: Biomechanics and Biomaterials; Tissue Engineering; and Biosignal Processing* A hard-working desk reference providing all the essential material needed by biomedical and clinical engineers on a day-to-day basis * Fundamentals, key techniques,

  14. Biomedical engineering education--status and perspectives.

    Science.gov (United States)

    Magjarevic, Ratko; Zequera Diaz, Martha L

    2014-01-01

    Biomedical Engineering programs are present at a large number of universities all over the world with an increasing trend. New generations of biomedical engineers have to face the challenges of health care systems round the world which need a large number of professionals not only to support the present technology in the health care system but to develop new devices and services. Health care stakeholders would like to have innovative solutions directed towards solving problems of the world growing incidence of chronic disease and ageing population. These new solutions have to meet the requirements for continuous monitoring, support or care outside clinical settlements. Presence of these needs can be tracked through data from the Labor Organization in the U.S. showing that biomedical engineering jobs have the largest growth at the engineering labor market with expected 72% growth rate in the period from 2008-2018. In European Union the number of patents (i.e. innovation) is the highest in the category of biomedical technology. Biomedical engineering curricula have to adopt to the new needs and for expectations of the future. In this paper we want to give an overview of engineering professions in related to engineering in medicine and biology and the current status of BME education in some regions, as a base for further discussions.

  15. On Solution of the Integrable Initial Boundary Value Problem for KdV Equation on the Semi-axis

    Energy Technology Data Exchange (ETDEWEB)

    Ignatyev, Mikhail Yurievich, E-mail: mikkieram@gmail.com [Saratov State University, Department of Mathematics (Russian Federation)

    2013-12-15

    This paper is concerned with the Korteweg-de Vries (KdV) equation on the right semi-axis. The initial boundary value problem with inhomogeneous integrable boundary conditions is studied. We show that, under some conditions on the initial data the problem has a solution and provide the procedure for constructing this solution. The procedure is based on the inverse spectral method and consists of several steps reducing to either solving some linear problems or calculations via some explicit formulas.

  16. Existence and Analytic Approximation of Solutions of Duffing Type Nonlinear Integro-Differential Equation with Integral Boundary Conditions

    Directory of Open Access Journals (Sweden)

    Alsaedi Ahmed

    2009-01-01

    Full Text Available A generalized quasilinearization technique is developed to obtain a sequence of approximate solutions converging monotonically and quadratically to a unique solution of a boundary value problem involving Duffing type nonlinear integro-differential equation with integral boundary conditions. The convergence of order for the sequence of iterates is also established. It is found that the work presented in this paper not only produces new results but also yields several old results in certain limits.

  17. SOLUTIONING

    Directory of Open Access Journals (Sweden)

    Maria de Hoyos Guajardo, Ph.D. Candidate, M.Sc., B.Eng.

    2004-11-01

    Full Text Available The theory that is presented below aims to conceptualise how a group of undergraduate students tackle non-routine mathematical problems during a problem-solving course. The aim of the course is to allow students to experience mathematics as a creative process and to reflect on their own experience. During the course, students are required to produce a written ‘rubric’ of their work, i.e., to document their thoughts as they occur as well as their emotionsduring the process. These ‘rubrics’ were used as the main source of data.Students’ problem-solving processes can be explained as a three-stage process that has been called ‘solutioning’. This process is presented in the six sections below. The first three refer to a common area of concern that can be called‘generating knowledge’. In this way, generating knowledge also includes issues related to ‘key ideas’ and ‘gaining understanding’. The third and the fourth sections refer to ‘generating’ and ‘validating a solution’, respectively. Finally, once solutions are generated and validated, students usually try to improve them further before presenting them as final results. Thus, the last section deals with‘improving a solution’. Although not all students go through all of the stages, it may be said that ‘solutioning’ considers students’ main concerns as they tackle non-routine mathematical problems.

  18. Review Strategies and Analysis of Mobile Ad Hoc Network- Internet Integration Solutions

    Directory of Open Access Journals (Sweden)

    Rakesh Kumar

    2010-07-01

    Full Text Available The desire to be connected anytime and anywhere has led to the development of wireless networks, opening new vista of research in pervasive and ubiquitous computing. Mobile Ad Hoc Networks (MANETs use portable devices such as mobile phones, laptops or personal digital assistants (PDAs for spontaneous establishment of communication. Most existing research in the area of mobile Ad Hoc Networks is limited to stand-alone isolated networks. But connectivity of a mobile Ad Hoc network to the Internet is also desirable as more and more applications and services in our society now depend on fixed infrastructure networks. It is therefore important that dynamically deployed wireless Ad Hoc networks should also gain access to these fixed networks and their services. The integration of MANETs into Internet increases the networking flexibility and coverage of existing infrastructure networks. Although researchers have proposed many solutions, but it is still unclear which one offer the best performance compared to the others. When an Ad Hoc network is connected to Internet, it is important for the mobile nodes to detect efficiently available Internet gateways providing access to the Internet. Internet gateway discovery time and handover delay have strong influence on packet delay and throughput. The key challenge in providing connectivity is to minimize the overhead of mobile IP and Ad Hoc routing protocol between Internet and Ad Hoc networks. There, this paper focuses on proposed technical solutions on Internet gateway discovery and also we briefly describe different ways to provide global Internet access for MANETs. Finally, some challenges are also mentioned which need in depth investigation.

  19. The integral representation of solutions of KZ equation and a modification by $\\mathcal{K}$ operator insertion

    CERN Document Server

    Yoshioka, Reiji

    2015-01-01

    A root of unity limit of the $q$-deformed Virasoro algebra is considered. The $\\widehat{sl}(2)_k$ current algebra and the integral formulas of the solutions of the KZ equations can be realized by the $q$-deformed boson at the limit and an additional boson. We explicitly construct the integral representation of the four-point blocks with a $\\mathcal{K}$-operator insertion.

  20. Sensors for biomedical applications

    NARCIS (Netherlands)

    Bergveld, Piet

    1986-01-01

    This paper considers the impact during the last decade of modern IC technology, microelectronics, thin- and thick-film technology, fibre optic technology, etc. on the development of sensors for biomedical applications.

  1. Biomedical signal processing

    CERN Document Server

    Akay, Metin

    1994-01-01

    Sophisticated techniques for signal processing are now available to the biomedical specialist! Written in an easy-to-read, straightforward style, Biomedical Signal Processing presents techniques to eliminate background noise, enhance signal detection, and analyze computer data, making results easy to comprehend and apply. In addition to examining techniques for electrical signal analysis, filtering, and transforms, the author supplies an extensive appendix with several computer programs that demonstrate techniques presented in the text.

  2. Statistics in biomedical research

    OpenAIRE

    González-Manteiga, Wenceslao; Cadarso-Suárez, Carmen

    2007-01-01

    The discipline of biostatistics is nowadays a fundamental scientific component of biomedical, public health and health services research. Traditional and emerging areas of application include clinical trials research, observational studies, physiology, imaging, and genomics. The present article reviews the current situation of biostatistics, considering the statistical methods traditionally used in biomedical research, as well as the ongoing development of new methods in response to the new p...

  3. Biomedical signal analysis

    CERN Document Server

    Rangayyan, Rangaraj M

    2015-01-01

    The book will help assist a reader in the development of techniques for analysis of biomedical signals and computer aided diagnoses with a pedagogical examination of basic and advanced topics accompanied by over 350 figures and illustrations. Wide range of filtering techniques presented to address various applications. 800 mathematical expressions and equations. Practical questions, problems and laboratory exercises. Includes fractals and chaos theory with biomedical applications.

  4. Optical Design for Biomedical Imaging

    CERN Document Server

    Liang, Rongguang

    2010-01-01

    Designing an efficient imaging system for biomedical optics requires a solid understanding of the special requirements of the optical systems for biomedical imaging and the optical components used in the systems. However, a lack of reference books on optical design (imaging and illumination) for biomedical imaging has led to some inefficient systems. This book fills the gap between biomedical optics and optical design by addressing the fundamentals of biomedical optics and optical engineering, and biomedical imaging systems. The first half provides a brief introduction to biomedical optics and

  5. Toward an ITRF2000 Combined Solution for the Southern California Integrated GPS Network

    Science.gov (United States)

    King, N. E.; Heflin, M.; Herring, T.; Hurst, K.; Kedar, S.; Langbein, J.; Prawirodirdjo, L.

    2002-12-01

    The Southern California Integrated GPS Network (SCIGN) has two independent centers for precise processing of data from 250 stations. The Jet Propulsion Laboratory (JPL) uses the GIPSY-OASIS II processing software and the Scripps Institution of Oceanography (SIO) uses the GAMIT/GLOBK/GLORG software. The first comparison of JPL and SIO results revealed discrepancies of several mm in station position and several mm/yr in station velocity; these differences were the result of inconsistent antenna heights, different methods of estimating velocity, and, especially, different reference frames. To combine JPL and SIO solutions in a consistent reference frame, we chose 75 stations with at least 500 days of data and horizontal RMS of 1 mm or less. Rotating and translating the frames to align these 75 stations generates 0.5 mm/yr horizontal RMS velocity difference. Adding the vertical component, the 3-dimensional RMS velocity difference is 1.2 mm/yr. In a consistent reference frame the SIO and JPL horizontal RMS position difference is less than 1 mm. Vertical differences, due to antenna height discrepancies, still have to be resolved. Current combinations are in a North American reference frame, but using stations from the global network will allow us to align the SCIGN stations in the ITRF2000 reference frame.

  6. Numerical path integral solution to strong Coulomb correlation in one dimensional Hooke's atom

    CERN Document Server

    Ruokosenmäki, Ilkka; Kylänpää, Ilkka; Rantala, Tapio T

    2015-01-01

    We present a new approach based on real time domain Feynman path integrals (RTPI) for electronic structure calculations and quantum dynamics, which includes correlations between particles exactly but within the numerical accuracy. We demonstrate that incoherent propagation by keeping the wave function real is a novel method for finding and simulation of the ground state, similar to Diffusion Monte Carlo (DMC) method, but introducing new useful tools lacking in DMC. We use 1D Hooke's atom, a two-electron system with very strong correlation, as our test case, which we solve with incoherent RTPI (iRTPI) and compare against DMC. This system provides an excellent test case due to exact solutions for some confinements and because in 1D the Coulomb singularity is stronger than in two or three dimensional space. The use of Monte Carlo grid is shown to be efficient for which we determine useful numerical parameters. Furthermore, we discuss another novel approach achieved by combining the strengths of iRTPI and DMC. We...

  7. Analytic solution of two-density integral equations for sticky Janus dumbbells with arbitrary monomer diameters

    Science.gov (United States)

    Gazzillo, Domenico; Munaò, Gianmarco; Prestipino, Santi

    2016-06-01

    We study a pure fluid of heteronuclear sticky Janus dumbbells, considered to be the result of complete chemical association between unlike species in an initially equimolar mixture of hard spheres (species A) and sticky hard spheres (species B) with different diameters. The B spheres are particles whose attractive surface layer is infinitely thin. Wertheim's two-density integral equations are employed to describe the mixture of AB dumbbells together with unbound A and B monomers. After Baxter factorization, these equations are solved analytically within the associative Percus-Yevick approximation. The limit of complete association is taken at the end. The present paper extends to the more general, heteronuclear case of A and B species with size asymmetry a previous study by Wu and Chiew [J. Chem. Phys. 115, 6641 (2001)], which was restricted to dumbbells with equal monomer diameters. Furthermore, the solution for the Baxter factor correlation functions qi j α β ( r ) is determined here in a fully analytic way, since we have been able to find explicit analytic expressions for all the intervening parameters.

  8. STAR: an integrated solution to management and visualization of sequencing data

    Science.gov (United States)

    Wang, Tao; Liu, Jie; Shen, Li; Tonti-Filippini, Julian; Zhu, Yun; Jia, Haiyang; Lister, Ryan; Whitaker, John W.; Ecker, Joseph R.; Millar, A. Harvey; Ren, Bing; Wang, Wei

    2013-01-01

    Motivation: Easily visualization of complex data features is a necessary step to conduct studies on next-generation sequencing (NGS) data. We developed STAR, an integrated web application that enables online management, visualization and track-based analysis of NGS data. Results: STAR is a multilayer web service system. On the client side, STAR leverages JavaScript, HTML5 Canvas and asynchronous communications to deliver a smoothly scrolling desktop-like graphical user interface with a suite of in-browser analysis tools that range from providing simple track configuration controls to sophisticated feature detection within datasets. On the server side, STAR supports private session state retention via an account management system and provides data management modules that enable collection, visualization and analysis of third-party sequencing data from the public domain with over thousands of tracks hosted to date. Overall, STAR represents a next-generation data exploration solution to match the requirements of NGS data, enabling both intuitive visualization and dynamic analysis of data. Availability and implementation: STAR browser system is freely available on the web at http://wanglab.ucsd.edu/star/browser and https://github.com/angell1117/STAR-genome-browser. Contact: wei-wang@ucsd.edu PMID:24078702

  9. Integrating Water Flow, Solute Transport and Crop Production Models At The Farm-scale

    Science.gov (United States)

    Assinck, F. B. T.; de Vos, J. A.

    Minimising nitrate pollution of ground and surface water and optimising agricultural yields are problems which have to be addressed at the farm-scale. However, simulation models usually operate at the field-scale. We coupled the subsurface hydrology model SWAP with other existing deterministic (sub)models for solute transport, organic mat- ter dynamics, crop growth, and dairy farm management at the farm-scale, resulting in the model WATERPAS. The (sub)models are coupled in a Framework environment obeying the principles of object oriented modelling. Based on daily weather data, groundwater regimes, soil and farm characteristics WATERPAS is able to simulate the water and nutrient balances, grass production, economical benefits, nitrate leaching and greenhouse gas emissions at a farm. Problems of coupling, such as data-transfer, quality checks, over-parameterisation, complexity and sensitivity of the systems are discussed. Application of deducted simpler models and expert judgement can be use- ful for practical use. However, we believe that integrated models are a powerful tool to understand the complex relationships between the different processes. It also gives opportunities to perform scenario analysis for future boundary conditions, i.e. due to changing farm management, (sea) water levels and climate change.

  10. Integrated heterogeneous sono-photo Fenton processes for the degradation of phenolic aqueous solutions.

    Science.gov (United States)

    Segura, Y; Molina, R; Martínez, F; Melero, J A

    2009-03-01

    The removal of organic compounds from aqueous solutions has been tackled by a novel integrated heterogeneous system. The efficacy of the different systems has been assessed using Fenton-like processes (H2O2/Fe2O3-SBA-15) and phenol as model pollutant. Sono- and photo-Fenton processes separately applied as well as combined systems were studied in order to evaluate of possible beneficial effects on the use of coupled systems. The sequential system evidences an enhancement in terms of phenol and TOC conversions compared to the ultrasound or UV-light irradiation processes. A total phenol degradation and ca. 90% TOC reduction are achieved by sequentially ultrasound followed by UV-visible light irradiation. These effects are ascribed cavitation effect of ultrasound producing a reduction of particle size that provides a higher amount of available active sites due to an increased surface area for the subsequent photo-Fenton system. These encouraging results open new paths for the existing oxidation technologies for potable water and wastewater treatment.

  11. Existence and uniqueness of solutions for a class of integral equations by common fixed point theorems in IFMT-spaces

    Directory of Open Access Journals (Sweden)

    Reza Saadati

    2016-08-01

    Full Text Available Abstract In this paper, our aim is to address the existence and uniqueness of solutions for a class of integral equations in IFMT-space. Therefore, we introduce the concept of IFMT-spaces and prove a common fixed point theorem in a complete IFMT-space; next we study an application.

  12. Existence and Uniqueness of Solutions for the System of Nonlinear Fractional Differential Equations with Nonlocal and Integral Boundary Conditions

    Directory of Open Access Journals (Sweden)

    Allaberen Ashyralyev

    2012-01-01

    Full Text Available In the present study, the nonlocal and integral boundary value problems for the system of nonlinear fractional differential equations involving the Caputo fractional derivative are investigated. Theorems on existence and uniqueness of a solution are established under some sufficient conditions on nonlinear terms. A simple example of application of the main result of this paper is presented.

  13. MULTIPLICITY OF NONNEGATIVE SOLUTIONS TO SECOND-ORDER SINGULAR DIFFERENTIAL EQUATION WITH INTEGRAL BOUNDARY CONDITIONS IN BANACH SPACES

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    This paper investigates the existence and multiplicity of nonnegative solutions to a singular nonlinear boundary value problem of second order differential equations with integral boundary conditions in a Banach space. The arguments are based on the construction of a nonempty bounded open convex set and fixed point index theory. Our nonlinearity possesses singularity and first derivative which makes it different with that in [10].

  14. Positive Solutions for a Second-Order Nonlinear Impulsive Singular Integro-Differential Equation with Integral Conditions in Banach Spaces

    Institute of Scientific and Technical Information of China (English)

    Xingqiu ZHANG

    2012-01-01

    The existence of positive solutions to a boundary value problem of second-order impulsive singular integro-differential equation with integral boundary conditions in a Banach space is obtained by means of fixed point theory.Moreover,an application is also given to illustrate the main result.

  15. Development and integration of block operations for data invariant automation of digital preprocessing and analysis of biological and biomedical Raman spectra.

    Science.gov (United States)

    Schulze, H Georg; Turner, Robin F B

    2015-06-01

    High-throughput information extraction from large numbers of Raman spectra is becoming an increasingly taxing problem due to the proliferation of new applications enabled using advances in instrumentation. Fortunately, in many of these applications, the entire process can be automated, yielding reproducibly good results with significant time and cost savings. Information extraction consists of two stages, preprocessing and analysis. We focus here on the preprocessing stage, which typically involves several steps, such as calibration, background subtraction, baseline flattening, artifact removal, smoothing, and so on, before the resulting spectra can be further analyzed. Because the results of some of these steps can affect the performance of subsequent ones, attention must be given to the sequencing of steps, the compatibility of these sequences, and the propensity of each step to generate spectral distortions. We outline here important considerations to effect full automation of Raman spectral preprocessing: what is considered full automation; putative general principles to effect full automation; the proper sequencing of processing and analysis steps; conflicts and circularities arising from sequencing; and the need for, and approaches to, preprocessing quality control. These considerations are discussed and illustrated with biological and biomedical examples reflecting both successful and faulty preprocessing.

  16. Translational research platforms integrating clinical and omics data: a review of publicly available solutions

    OpenAIRE

    2014-01-01

    The rise of personalized medicine and the availability of high-throughput molecular analyses in the context of clinical care have increased the need for adequate tools for translational researchers to manage and explore these data. We reviewed the biomedical literature for translational platforms allowing the management and exploration of clinical and omics data, and identified seven platforms: BRISK, caTRIP, cBio Cancer Portal, G-DOC, iCOD, iDASH and tranSMART. We analyzed these platforms al...

  17. Analytical solution to the 1D Lemaitre's isotropic damage model and plane stress projected implicit integration procedure

    DEFF Research Database (Denmark)

    Andriollo, Tito; Thorborg, Jesper; Hattel, Jesper Henri

    2016-01-01

    obtaining an integral relationship between total strain and effective stress. By means of the generalized binomial theorem, an expression in terms of infinite series is subsequently derived. The solution is found to simplify considerably existing techniques for material parameters identification based...... on optimization, as all issues associated with classical numerical solution procedures of the constitutive equations are eliminated. In addition, an implicit implementation of the plane stress projected version of Lemaitre's model is discussed, showing that the resulting algebraic system can be reduced...... to a single non-linear equation. The accuracy of the proposed integration scheme is then verified by means of the presented 1D analytical solution. Finally, a closed-form expression for the consistent tangent modulus taking damage evolution into account is given, and its impact on the convergence rate...

  18. Should biomedical research be like Airbnb?

    Science.gov (United States)

    Bonazzi, Vivien R; Bourne, Philip E

    2017-04-01

    The thesis presented here is that biomedical research is based on the trusted exchange of services. That exchange would be conducted more efficiently if the trusted software platforms to exchange those services, if they exist, were more integrated. While simpler and narrower in scope than the services governing biomedical research, comparison to existing internet-based platforms, like Airbnb, can be informative. We illustrate how the analogy to internet-based platforms works and does not work and introduce The Commons, under active development at the National Institutes of Health (NIH) and elsewhere, as an example of the move towards platforms for research.

  19. Applications of protein biochips in biomedical and biotechnological research

    NARCIS (Netherlands)

    Weinrich, Dirk; Jonkheijm, Pascal; Niemeyer, Christof M.; Waldmann, Herbert

    2009-01-01

    Progress in the development of protein-immobilization strategies and methods has made protein biochips increasingly accessible. The integration of these assay and analysis platforms into biomedical and biotechnological research has substantially expanded the repertoire of methods available for prote

  20. Biomedical Applications for Introductory Physics

    Science.gov (United States)

    Tuszynski, J. A.; Dixon, J. M.

    2001-12-01

    Can be utilized in either Algebra or Calculus-based courses and is available either as a standalone text or as a supplement for books like Cutnell PHYSICS, 5e or Halliday, Resnick, & Walker FUNDAMENTALS OF PHYSICS, 6e. Math level is Algebra & Trigonometry; however, a few examples require the use of integration and differentiation. Unlike competing supplements, Tuszinski offers both a wealth of engaging biomedical applications as well as quantitative problem-solving. The quantitative problem-solving is presented in the form of worked examples and homework problems. The quantitative problem-solving is presented in the form of worked examples and homework problems. The standard organization facilitates the integration of the material into most introductory courses.

  1. New types of multisoliton solutions of some integrable equations via direct methods

    Science.gov (United States)

    Burde, Georgy I.

    2016-06-01

    Exact explicit solutions, which describe new multisoliton dynamics, have been identified for some KdV type equations using direct methods devised for this purpose. It is found that the equations, having multi-soliton solutions in terms of the KdV-type solitons, possess also an alternative set of multi-soliton solutions which include localized static structures that behave like (static) solitons when they collide with moving solitons. The alternative sets of solutions include the steady-state solution describing the static soliton itself and unsteady solutions describing mutual interactions in a system consisting of a static soliton and several moving solitons. As distinct from common multisoliton solutions those solutions represent combinations of algebraic and hyperbolic functions and cannot be obtained using the traditional methods of soliton theory.

  2. BIOMedical Search Engine Framework: Lightweight and customized implementation of domain-specific biomedical search engines.

    Science.gov (United States)

    Jácome, Alberto G; Fdez-Riverola, Florentino; Lourenço, Anália

    2016-07-01

    Text mining and semantic analysis approaches can be applied to the construction of biomedical domain-specific search engines and provide an attractive alternative to create personalized and enhanced search experiences. Therefore, this work introduces the new open-source BIOMedical Search Engine Framework for the fast and lightweight development of domain-specific search engines. The rationale behind this framework is to incorporate core features typically available in search engine frameworks with flexible and extensible technologies to retrieve biomedical documents, annotate meaningful domain concepts, and develop highly customized Web search interfaces. The BIOMedical Search Engine Framework integrates taggers for major biomedical concepts, such as diseases, drugs, genes, proteins, compounds and organisms, and enables the use of domain-specific controlled vocabulary. Technologies from the Typesafe Reactive Platform, the AngularJS JavaScript framework and the Bootstrap HTML/CSS framework support the customization of the domain-oriented search application. Moreover, the RESTful API of the BIOMedical Search Engine Framework allows the integration of the search engine into existing systems or a complete web interface personalization. The construction of the Smart Drug Search is described as proof-of-concept of the BIOMedical Search Engine Framework. This public search engine catalogs scientific literature about antimicrobial resistance, microbial virulence and topics alike. The keyword-based queries of the users are transformed into concepts and search results are presented and ranked accordingly. The semantic graph view portraits all the concepts found in the results, and the researcher may look into the relevance of different concepts, the strength of direct relations, and non-trivial, indirect relations. The number of occurrences of the concept shows its importance to the query, and the frequency of concept co-occurrence is indicative of biological relations

  3. Dalia integrated production bundle (IPB): an innovative riser solution for deep water fields

    Energy Technology Data Exchange (ETDEWEB)

    Reals, Th Boscals de; Gloaguen, M.; Roche, F. [Total E and P (Angola); Marion, A.; Poincheval, A. [Technip, Paris (France)

    2008-07-01

    The Dalia field is located 210 km north west of Luanda (Angola), about 140 km from shore in 1400 meter water-depth. It was the second major discovery out of 15 made in the block 17 operated by Total. The Dalia Umbilical, Flow lines and Risers EPCI Contract was awarded in 2003. The sea-line network to connect and control the 71 wells and 9 manifolds consist of the following: 40 km of insulated pipe in pipe (12 inches into 17 inches) production flow lines; 45 km of 12 inches water and gas injection lines; 6 off 1.7 km flexible water and gas injection risers; 8 off 1.65 km flexible Integrated Production Bundle (IPB) risers; 75 km of control umbilicals. The flow assurance and associated insulation requirement of the production transport system was one of the main challenges of the project. With a crude temperature of 45 deg C at the wellhead and the required minimum temperature of 35 deg C on arrival at the FPSO, this problem was complex. Understanding that, due to the Joule Thompson effect of the riser gas lift, a 'built in' loss of about 5 deg C is induced and together with further losses through the sub sea pipelines, some up to 6 km long, the agreed solution was 'pipe in pipe' for the production flow lines. The innovative flexible IPB riser, incorporating gas lift and heating to keep the fluid temperature above hydrate formation zone, was the selected riser solution. The IPB is new technology for deep water, developed by Technip for Dalia, and consists of a 12 inches nominal central flexible, surrounded by layers of heat tracing cables, small bore gas lift lines, optical fibres and many insulation layers with an Overall Heat Transfer Coefficient of approximately 3,4 W/m{sup 2}K. After an earlier research and development programme, a further extensive qualification programme was conducted during the course of the project, culminating with the deep water testing phase offshore Brazil. The IPB was then approved for fabrication and installation

  4. Bio-Medical Factors and External Hazards in Space Station Design

    Science.gov (United States)

    Olling, Edward H.

    1966-01-01

    The design of space-station configurations is influenced by many factors, Probably the most demanding and critical are the biomedical and external hazards requirements imposed to provide the proper environment and supporting facilities for the crew and the adequate protective measures necessary to provide a configuration in which the crew can live and work efficiently in relative comfort and safety. The major biomedical factors, such as physiology, psychology, nutrition, personal hygiene, waste management, and recreation, all impose their own peculiar requirements. The commonality and integration of these requirements demand the utmost ingenuity and inventiveness be exercised in order to achieve effective configuration compliance. The relationship of biomedical factors for the internal space-station environment will be explored with respect to internal atmospheric constituency, atmospheric pressure levels, oxygen positive pressure, temperature, humidity, CO2 concentration, and atmospheric contamination. The range of these various parameters and the recommended levels for design use will be analyzed. Requirements and criteria for specific problem areas such as zero and artificial gravity and crew private quarters will be reviewed and the impact on the design of representative solutions will be presented. In the areas of external hazards, the impact of factors such as meteoroids, radiation, vacuum, temperature extremes, and cycling on station design will be evaluated. Considerations with respect to operational effectiveness and crew safety will be discussed. The impact of such factors on spacecraft design to achieve acceptable launch and reentry g levels, crew rotation intervals, etc., will be reviewed. Examples of configurations, subsystems, and internal a arrangement and installations to comply with such biomedical factor requirements will ber presented. The effects of solutions to certain biomedical factors on configuration weight, operational convenience, and

  5. Solution with Singularity of Order One for Singular Integral Equation with Hilbert Kernal

    Institute of Scientific and Technical Information of China (English)

    Zhong Shou-guo; Chen Jing-song

    2004-01-01

    The basic sets of solutions in class H( or H*) for the characteristic equation and its adjoint equation with Hilbert kernel are given respectively. Thus the expressions of solutions and its solvable conditions are simplified. On this basis the solutions and the solvable conditions in class H*1 as well as the generalized Noether theorem for the complete equation are obtained.

  6. Analytical solution for stress and deformation of the mining floor based on integral transform

    Institute of Scientific and Technical Information of China (English)

    Feng Qiang; Jiang Binsong

    2015-01-01

    Following exploitation of a coal seam, the final stress field is the sum of in situ stress field and an exca-vation stress field. Based on this feature, we firstly established a mechanics analytical model of the min-ing floor strata. Then the study applied Fourier integral transform to solve a biharmonic equation, obtaining the analytical solution of the stress and displacement of the mining floor. Additionally, this investigation used the Mohr–Coulomb yield criterion to determine the plastic failure depth of the floor strata. The calculation process showed that the plastic failure depth of the floor and floor heave are related to the mining width, burial depth and physical–mechanical properties. The results from an exam-ple show that the curve of the plastic failure depth of the mining floor is characterized by a funnel shape and the maximum failure depth generates in the middle of mining floor;and that the maximum and min-imum principal stresses change distinctly in the shallow layer and tend to a fixed value with an increase in depth. Based on the displacement results, the maximum floor heave appears in the middle of the stope and its value is 0.107 m. This will provide a basis for floor control. Lastly, we have verified the analytical results using FLAC3D to simulate floor excavation and find that there is some deviation between the two results, but their overall tendency is consistent which illustrates that the analysis method can well solve the stress and displacement of the floor.

  7. Overview of progress in European medium sized tokamaks towards an integrated plasma-edge/wall solution

    Science.gov (United States)

    Meyer, H.; Eich, T.; Beurskens, M.; Coda, S.; Hakola, A.; Martin, P.; Adamek, J.; Agostini, M.; Aguiam, D.; Ahn, J.; Aho-Mantila, L.; Akers, R.; Albanese, R.; Aledda, R.; Alessi, E.; Allan, S.; Alves, D.; Ambrosino, R.; Amicucci, L.; Anand, H.; Anastassiou, G.; Andrèbe, Y.; Angioni, C.; Apruzzese, G.; Ariola, M.; Arnichand, H.; Arter, W.; Baciero, A.; Barnes, M.; Barrera, L.; Behn, R.; Bencze, A.; Bernardo, J.; Bernert, M.; Bettini, P.; Bilková, P.; Bin, W.; Birkenmeier, G.; Bizarro, J. P. S.; Blanchard, P.; Blanken, T.; Bluteau, M.; Bobkov, V.; Bogar, O.; Böhm, P.; Bolzonella, T.; Boncagni, L.; Botrugno, A.; Bottereau, C.; Bouquey, F.; Bourdelle, C.; Brémond, S.; Brezinsek, S.; Brida, D.; Brochard, F.; Buchanan, J.; Bufferand, H.; Buratti, P.; Cahyna, P.; Calabrò, G.; Camenen, Y.; Caniello, R.; Cannas, B.; Canton, A.; Cardinali, A.; Carnevale, D.; Carr, M.; Carralero, D.; Carvalho, P.; Casali, L.; Castaldo, C.; Castejón, F.; Castro, R.; Causa, F.; Cavazzana, R.; Cavedon, M.; Cecconello, M.; Ceccuzzi, S.; Cesario, R.; Challis, C. D.; Chapman, I. T.; Chapman, S.; Chernyshova, M.; Choi, D.; Cianfarani, C.; Ciraolo, G.; Citrin, J.; Clairet, F.; Classen, I.; Coelho, R.; Coenen, J. W.; Colas, L.; Conway, G.; Corre, Y.; Costea, S.; Crisanti, F.; Cruz, N.; Cseh, G.; Czarnecka, A.; D'Arcangelo, O.; De Angeli, M.; De Masi, G.; De Temmerman, G.; De Tommasi, G.; Decker, J.; Delogu, R. S.; Dendy, R.; Denner, P.; Di Troia, C.; Dimitrova, M.; D'Inca, R.; Dorić, V.; Douai, D.; Drenik, A.; Dudson, B.; Dunai, D.; Dunne, M.; Duval, B. P.; Easy, L.; Elmore, S.; Erdös, B.; Esposito, B.; Fable, E.; Faitsch, M.; Fanni, A.; Fedorczak, N.; Felici, F.; Ferreira, J.; Février, O.; Ficker, O.; Fietz, S.; Figini, L.; Figueiredo, A.; Fil, A.; Fishpool, G.; Fitzgerald, M.; Fontana, M.; Ford, O.; Frassinetti, L.; Fridström, R.; Frigione, D.; Fuchert, G.; Fuchs, C.; Furno Palumbo, M.; Futatani, S.; Gabellieri, L.; Gałązka, K.; Galdon-Quiroga, J.; Galeani, S.; Gallart, D.; Gallo, A.; Galperti, C.; Gao, Y.; Garavaglia, S.; Garcia, J.; Garcia-Carrasco, A.; Garcia-Lopez, J.; Garcia-Munoz, M.; Gardarein, J.-L.; Garzotti, L.; Gaspar, J.; Gauthier, E.; Geelen, P.; Geiger, B.; Ghendrih, P.; Ghezzi, F.; Giacomelli, L.; Giannone, L.; Giovannozzi, E.; Giroud, C.; Gleason González, C.; Gobbin, M.; Goodman, T. P.; Gorini, G.; Gospodarczyk, M.; Granucci, G.; Gruber, M.; Gude, A.; Guimarais, L.; Guirlet, R.; Gunn, J.; Hacek, P.; Hacquin, S.; Hall, S.; Ham, C.; Happel, T.; Harrison, J.; Harting, D.; Hauer, V.; Havlickova, E.; Hellsten, T.; Helou, W.; Henderson, S.; Hennequin, P.; Heyn, M.; Hnat, B.; Hölzl, M.; Hogeweij, D.; Honoré, C.; Hopf, C.; Horáček, J.; Hornung, G.; Horváth, L.; Huang, Z.; Huber, A.; Igitkhanov, J.; Igochine, V.; Imrisek, M.; Innocente, P.; Ionita-Schrittwieser, C.; Isliker, H.; Ivanova-Stanik, I.; Jacobsen, A. S.; Jacquet, P.; Jakubowski, M.; Jardin, A.; Jaulmes, F.; Jenko, F.; Jensen, T.; Jeppe Miki Busk, O.; Jessen, M.; Joffrin, E.; Jones, O.; Jonsson, T.; Kallenbach, A.; Kallinikos, N.; Kálvin, S.; Kappatou, A.; Karhunen, J.; Karpushov, A.; Kasilov, S.; Kasprowicz, G.; Kendl, A.; Kernbichler, W.; Kim, D.; Kirk, A.; Kjer, S.; Klimek, I.; Kocsis, G.; Kogut, D.; Komm, M.; Korsholm, S. B.; Koslowski, H. R.; Koubiti, M.; Kovacic, J.; Kovarik, K.; Krawczyk, N.; Krbec, J.; Krieger, K.; Krivska, A.; Kube, R.; Kudlacek, O.; Kurki-Suonio, T.; Labit, B.; Laggner, F. M.; Laguardia, L.; Lahtinen, A.; Lalousis, P.; Lang, P.; Lauber, P.; Lazányi, N.; Lazaros, A.; Le, H. B.; Lebschy, A.; Leddy, J.; Lefévre, L.; Lehnen, M.; Leipold, F.; Lessig, A.; Leyland, M.; Li, L.; Liang, Y.; Lipschultz, B.; Liu, Y. Q.; Loarer, T.; Loarte, A.; Loewenhoff, T.; Lomanowski, B.; Loschiavo, V. P.; Lunt, T.; Lupelli, I.; Lux, H.; Lyssoivan, A.; Madsen, J.; Maget, P.; Maggi, C.; Maggiora, R.; Magnussen, M. L.; Mailloux, J.; Maljaars, B.; Malygin, A.; Mantica, P.; Mantsinen, M.; Maraschek, M.; Marchand, B.; Marconato, N.; Marini, C.; Marinucci, M.; Markovic, T.; Marocco, D.; Marrelli, L.; Martin, Y.; Solis, J. R. Martin; Martitsch, A.; Mastrostefano, S.; Mattei, M.; Matthews, G.; Mavridis, M.; Mayoral, M.-L.; Mazon, D.; McCarthy, P.; McAdams, R.; McArdle, G.; McCarthy, P.; McClements, K.; McDermott, R.; McMillan, B.; Meisl, G.; Merle, A.; Meyer, O.; Milanesio, D.; Militello, F.; Miron, I. G.; Mitosinkova, K.; Mlynar, J.; Mlynek, A.; Molina, D.; Molina, P.; Monakhov, I.; Morales, J.; Moreau, D.; Morel, P.; Moret, J.-M.; Moro, A.; Moulton, D.; Müller, H. W.; Nabais, F.; Nardon, E.; Naulin, V.; Nemes-Czopf, A.; Nespoli, F.; Neu, R.; Nielsen, A. H.; Nielsen, S. K.; Nikolaeva, V.; Nimb, S.; Nocente, M.; Nouailletas, R.; Nowak, S.; Oberkofler, M.; Oberparleiter, M.; Ochoukov, R.; Odstrčil, T.; Olsen, J.; Omotani, J.; O'Mullane, M. G.; Orain, F.; Osterman, N.; Paccagnella, R.; Pamela, S.; Pangione, L.; Panjan, M.; Papp, G.; Papřok, R.; Parail, V.; Parra, F. I.; Pau, A.; Pautasso, G.; Pehkonen, S.-P.; Pereira, A.; Perelli Cippo, E.; Pericoli Ridolfini, V.; Peterka, M.; Petersson, P.; Petrzilka, V.; Piovesan, P.; Piron, C.; Pironti, A.; Pisano, F.; Pisokas, T.; Pitts, R.; Ploumistakis, I.; Plyusnin, V.; Pokol, G.; Poljak, D.; Pölöskei, P.; Popovic, Z.; Pór, G.; Porte, L.; Potzel, S.; Predebon, I.; Preynas, M.; Primc, G.; Pucella, G.; Puiatti, M. E.; Pütterich, T.; Rack, M.; Ramogida, G.; Rapson, C.; Rasmussen, J. Juul; Rasmussen, J.; Rattá, G. A.; Ratynskaia, S.; Ravera, G.; Réfy, D.; Reich, M.; Reimerdes, H.; Reimold, F.; Reinke, M.; Reiser, D.; Resnik, M.; Reux, C.; Ripamonti, D.; Rittich, D.; Riva, G.; Rodriguez-Ramos, M.; Rohde, V.; Rosato, J.; Ryter, F.; Saarelma, S.; Sabot, R.; Saint-Laurent, F.; Salewski, M.; Salmi, A.; Samaddar, D.; Sanchis-Sanchez, L.; Santos, J.; Sauter, O.; Scannell, R.; Scheffer, M.; Schneider, M.; Schneider, B.; Schneider, P.; Schneller, M.; Schrittwieser, R.; Schubert, M.; Schweinzer, J.; Seidl, J.; Sertoli, M.; Šesnić, S.; Shabbir, A.; Shalpegin, A.; Shanahan, B.; Sharapov, S.; Sheikh, U.; Sias, G.; Sieglin, B.; Silva, C.; Silva, A.; Silva Fuglister, M.; Simpson, J.; Snicker, A.; Sommariva, C.; Sozzi, C.; Spagnolo, S.; Spizzo, G.; Spolaore, M.; Stange, T.; Stejner Pedersen, M.; Stepanov, I.; Stober, J.; Strand, P.; Šušnjara, A.; Suttrop, W.; Szepesi, T.; Tál, B.; Tala, T.; Tamain, P.; Tardini, G.; Tardocchi, M.; Teplukhina, A.; Terranova, D.; Testa, D.; Theiler, C.; Thornton, A.; Tolias, P.; Tophøj, L.; Treutterer, W.; Trevisan, G. L.; Tripsky, M.; Tsironis, C.; Tsui, C.; Tudisco, O.; Uccello, A.; Urban, J.; Valisa, M.; Vallejos, P.; Valovic, M.; Van den Brand, H.; Vanovac, B.; Varoutis, S.; Vartanian, S.; Vega, J.; Verdoolaege, G.; Verhaegh, K.; Vermare, L.; Vianello, N.; Vicente, J.; Viezzer, E.; Vignitchouk, L.; Vijvers, W. A. J.; Villone, F.; Viola, B.; Vlahos, L.; Voitsekhovitch, I.; Vondráček, P.; Vu, N. M. T.; Wagner, D.; Walkden, N.; Wang, N.; Wauters, T.; Weiland, M.; Weinzettl, V.; Westerhof, E.; Wiesenberger, M.; Willensdorfer, M.; Wischmeier, M.; Wodniak, I.; Wolfrum, E.; Yadykin, D.; Zagórski, R.; Zammuto, I.; Zanca, P.; Zaplotnik, R.; Zestanakis, P.; Zhang, W.; Zoletnik, S.; Zuin, M.; ASDEX Upgrade, the; MAST; TCV Teams

    2017-10-01

    Integrating the plasma core performance with an edge and scrape-off layer (SOL) that leads to tolerable heat and particle loads on the wall is a major challenge. The new European medium size tokamak task force (EU-MST) coordinates research on ASDEX Upgrade (AUG), MAST and TCV. This multi-machine approach within EU-MST, covering a wide parameter range, is instrumental to progress in the field, as ITER and DEMO core/pedestal and SOL parameters are not achievable simultaneously in present day devices. A two prong approach is adopted. On the one hand, scenarios with tolerable transient heat and particle loads, including active edge localised mode (ELM) control are developed. On the other hand, divertor solutions including advanced magnetic configurations are studied. Considerable progress has been made on both approaches, in particular in the fields of: ELM control with resonant magnetic perturbations (RMP), small ELM regimes, detachment onset and control, as well as filamentary scrape-off-layer transport. For example full ELM suppression has now been achieved on AUG at low collisionality with n  =  2 RMP maintaining good confinement {{H}\\text{H≤ft(98,\\text{y}2\\right)}}≈ 0.95 . Advances have been made with respect to detachment onset and control. Studies in advanced divertor configurations (Snowflake, Super-X and X-point target divertor) shed new light on SOL physics. Cross field filamentary transport has been characterised in a wide parameter regime on AUG, MAST and TCV progressing the theoretical and experimental understanding crucial for predicting first wall loads in ITER and DEMO. Conditions in the SOL also play a crucial role for ELM stability and access to small ELM regimes. In the future we will refer to the author list of the paper as the EUROfusion MST1 Team.

  8. Optomechatronics for Biomedical Optical Imaging: An Overview

    Directory of Open Access Journals (Sweden)

    Cho Hyungsuck

    2015-01-01

    Full Text Available The use of optomechatronic technology, particularly in biomedical optical imaging, is becoming pronounced and ever increasing due to its synergistic effect of the integration of optics and mechatronics. The background of this trend is that the biomedical optical imaging for example in-vivo imaging related to retraction of tissues, diagnosis, and surgical operations have a variety of challenges due to complexity in internal structure and properties of biological body and the resulting optical phenomena. This paper addresses the technical issues related to tissue imaging, visualization of interior surfaces of organs, laparoscopic and endoscopic imaging and imaging of neuronal activities and structures. Within such problem domains the paper overviews the states of the art technology focused on how optical components are fused together with those of mechatronics to create the functionalities required for the imaging systems. Future perspective of the optical imaging in biomedical field is presented in short.

  9. Personalized biomedical devices & systems for healthcare applications

    Science.gov (United States)

    Chen, I.-Ming; Phee, Soo Jay; Luo, Zhiqiang; Lim, Chee Kian

    2011-03-01

    With the advancement in micro- and nanotechnology, electromechanical components and systems are getting smaller and smaller and gradually can be applied to the human as portable, mobile and even wearable devices. Healthcare industry have started to benefit from this technology trend by providing more and more miniature biomedical devices for personalized medical treatments in order to obtain better and more accurate outcome. This article introduces some recent development in non-intrusive and intrusive biomedical devices resulted from the advancement of niche miniature sensors and actuators, namely, wearable biomedical sensors, wearable haptic devices, and ingestible medical capsules. The development of these devices requires carful integration of knowledge and people from many different disciplines like medicine, electronics, mechanics, and design. Furthermore, designing affordable devices and systems to benefit all mankind is a great challenge ahead. The multi-disciplinary nature of the R&D effort in this area provides a new perspective for the future mechanical engineers.

  10. Discovering relations between indirectly connected biomedical concepts.

    Science.gov (United States)

    Weissenborn, Dirk; Schroeder, Michael; Tsatsaronis, George

    2015-01-01

    The complexity and scale of the knowledge in the biomedical domain has motivated research work towards mining heterogeneous data from both structured and unstructured knowledge bases. Towards this direction, it is necessary to combine facts in order to formulate hypotheses or draw conclusions about the domain concepts. This work addresses this problem by using indirect knowledge connecting two concepts in a knowledge graph to discover hidden relations between them. The graph represents concepts as vertices and relations as edges, stemming from structured (ontologies) and unstructured (textual) data. In this graph, path patterns, i.e. sequences of relations, are mined using distant supervision that potentially characterize a biomedical relation. It is possible to identify characteristic path patterns of biomedical relations from this representation using machine learning. For experimental evaluation two frequent biomedical relations, namely "has target", and "may treat", are chosen. Results suggest that relation discovery using indirect knowledge is possible, with an AUC that can reach up to 0.8, a result which is a great improvement compared to the random classification, and which shows that good predictions can be prioritized by following the suggested approach. Analysis of the results indicates that the models can successfully learn expressive path patterns for the examined relations. Furthermore, this work demonstrates that the constructed graph allows for the easy integration of heterogeneous information and discovery of indirect connections between biomedical concepts.

  11. Elastic-Plastic J-Integral Solutions or Surface Cracks in Tension Using an Interpolation Methodology. Appendix C -- Finite Element Models Solution Database File, Appendix D -- Benchmark Finite Element Models Solution Database File

    Science.gov (United States)

    Allen, Phillip A.; Wells, Douglas N.

    2013-01-01

    No closed form solutions exist for the elastic-plastic J-integral for surface cracks due to the nonlinear, three-dimensional nature of the problem. Traditionally, each surface crack must be analyzed with a unique and time-consuming nonlinear finite element analysis. To overcome this shortcoming, the authors have developed and analyzed an array of 600 3D nonlinear finite element models for surface cracks in flat plates under tension loading. The solution space covers a wide range of crack shapes and depths (shape: 0.2 less than or equal to a/c less than or equal to 1, depth: 0.2 less than or equal to a/B less than or equal to 0.8) and material flow properties (elastic modulus-to-yield ratio: 100 less than or equal to E/ys less than or equal to 1,000, and hardening: 3 less than or equal to n less than or equal to 20). The authors have developed a methodology for interpolating between the goemetric and material property variables that allows the user to reliably evaluate the full elastic-plastic J-integral and force versus crack mouth opening displacement solution; thus, a solution can be obtained very rapidly by users without elastic-plastic fracture mechanics modeling experience. Complete solutions for the 600 models and 25 additional benchmark models are provided in tabular format.

  12. Elastic-Plastic J-Integral Solutions or Surface Cracks in Tension Using an Interpolation Methodology. Appendix C -- Finite Element Models Solution Database File, Appendix D -- Benchmark Finite Element Models Solution Database File

    Science.gov (United States)

    Allen, Phillip A.; Wells, Douglas N.

    2013-01-01

    No closed form solutions exist for the elastic-plastic J-integral for surface cracks due to the nonlinear, three-dimensional nature of the problem. Traditionally, each surface crack must be analyzed with a unique and time-consuming nonlinear finite element analysis. To overcome this shortcoming, the authors have developed and analyzed an array of 600 3D nonlinear finite element models for surface cracks in flat plates under tension loading. The solution space covers a wide range of crack shapes and depths (shape: 0.2 less than or equal to a/c less than or equal to 1, depth: 0.2 less than or equal to a/B less than or equal to 0.8) and material flow properties (elastic modulus-to-yield ratio: 100 less than or equal to E/ys less than or equal to 1,000, and hardening: 3 less than or equal to n less than or equal to 20). The authors have developed a methodology for interpolating between the goemetric and material property variables that allows the user to reliably evaluate the full elastic-plastic J-integral and force versus crack mouth opening displacement solution; thus, a solution can be obtained very rapidly by users without elastic-plastic fracture mechanics modeling experience. Complete solutions for the 600 models and 25 additional benchmark models are provided in tabular format.

  13. Advances in biomedical engineering

    CERN Document Server

    Brown, J H U

    1976-01-01

    Advances in Biomedical Engineering, Volume 5, is a collection of papers that deals with application of the principles and practices of engineering to basic and applied biomedical research, development, and the delivery of health care. The papers also describe breakthroughs in health improvements, as well as basic research that have been accomplished through clinical applications. One paper examines engineering principles and practices that can be applied in developing therapeutic systems by a controlled delivery system in drug dosage. Another paper examines the physiological and materials vari

  14. Biomedical implantable microelectronics.

    Science.gov (United States)

    Meindl, J D

    1980-10-17

    Innovative applications of microelectronics in new biomedical implantable instruments offer a singular opportunity for advances in medical research and practice because of two salient factors: (i) beyond all other types of biomedical instruments, implants exploit fully the inherent technical advantages--complex functional capability, high reliability, lower power drain, small size and weight-of microelectronics, and (ii) implants bring microelectronics into intimate association with biological systems. The combination of these two factors enables otherwise impossible new experiments to be conducted and new paostheses developed that will improve the quality of human life.

  15. Biomedical enhancements as justice.

    Science.gov (United States)

    Nam, Jeesoo

    2015-02-01

    Biomedical enhancements, the applications of medical technology to make better those who are neither ill nor deficient, have made great strides in the past few decades. Using Amartya Sen's capability approach as my framework, I argue in this article that far from being simply permissible, we have a prima facie moral obligation to use these new developments for the end goal of promoting social justice. In terms of both range and magnitude, the use of biomedical enhancements will mark a radical advance in how we compensate the most disadvantaged members of society.

  16. Ethics in biomedical engineering.

    Science.gov (United States)

    Morsy, Ahmed; Flexman, Jennifer

    2008-01-01

    This session focuses on a number of aspects of the subject of Ethics in Biomedical Engineering. The session starts by providing a case study of a company that manufactures artificial heart valves where the valves were failing at an unexpected rate. The case study focuses on Biomedical Engineers working at the company and how their education and training did not prepare them to deal properly with such situation. The second part of the session highlights the need to learn about various ethics rules and policies regulating research involving human or animal subjects.

  17. Tipping Points and Balancing Acts: Grand Challenges and Synergistic Opportunities of Integrating Research and Education, Science and Solutions

    Science.gov (United States)

    McCaffrey, M. S.; Stroeve, J. C.

    2011-12-01

    The "Grand Challenges" to address Global Change identified by the International Council for Science (ICSU) and its partners through the Earth System Sustainability Initiative-improving forecasting, enhancing and integrating observation systems, confining and minimizing global environmental change, responding effectively to change, as well as innovating and evaluating these efforts-require an integrative approach that engages and inspires society in general and young people in particular. What are some of the effective strategies-and stumbling blocks-in being able to make Earth System science and related sustainability efforts relevant and practical to non-technical audiences? Recent climate education projects have pioneered new strategies toward linking and infusing research with education, science with solutions. For example, the Climate Literacy and Energy Awareness Network (CLEAN), a National Science Digital Library Pathway funded by NSF, has approached this integral approach by "closing the loop" between climate and energy topics, identifying and annotating high quality online resources relating to the carbon cycle and related topics. The Inspiring Climate Education Excellence (ICEE) project, funded by NASA, offers professional development for teachers that infuses climate science with solutions as an emerging "best practice" while being sensitive to the emotional, psychological and political aspects of avoiding "gloom and doom" on one hand or advocating for particular policy solutions on another. Other examples includes NASA's climate website (http://climate.nasa.gov ), which serves as a robust, engaging portal for climate research and data, especially for educators. The recent PBS series Earth: The Operators' Manual and related book and website are other recent example of how climate science research, education and solutions can be incorporated in a way that is appealing and informative. The Alliance for Climate Education (ACE) has given assemblies in

  18. A biobank management model applicable to biomedical research

    Directory of Open Access Journals (Sweden)

    Patenaude Johane

    2006-04-01

    Full Text Available Abstract Background The work of Research Ethics Boards (REBs, especially when involving genetics research and biobanks, has become more challenging with the growth of biotechnology and biomedical research. Some REBs have even rejected research projects where the use of a biobank with coded samples was an integral part of the study, the greatest fear being the lack of participant protection and uncontrolled use of biological samples or related genetic data. The risks of discrimination and stigmatization are a recurrent issue. In light of the increasing interest in biomedical research and the resulting benefits to the health of participants, it is imperative that practical solutions be found to the problems associated with the management of biobanks: namely, protecting the integrity of the research participants, as well as guaranteeing the security and confidentiality of the participant's information. Methods We aimed to devise a practical and efficient model for the management of biobanks in biomedical research where a medical archivist plays the pivotal role as a data-protection officer. The model had to reduce the burden placed on REBs responsible for the evaluation of genetics projects and, at the same time, maximize the protection of research participants. Results The proposed model includes the following: 1 a means of protecting the information in biobanks, 2 offers ways to provide follow-up information requested about the participants, 3 protects the participant's confidentiality and 4 adequately deals with the ethical issues at stake in biobanking. Conclusion Until a governmental governance body is established in Quebec to guarantee the protection of research participants and establish harmonized guidelines for the management of biobanks in medical research, it is definitely up to REBs to find solutions that the present lack of guidelines poses. The model presented in this article offers a practical solution on a day-to-day basis for REBs

  19. Direct Reduction and Exact Solutions for Generalized Variable Coefficients 2D KdV Equation under Some Integrability Conditions

    Institute of Scientific and Technical Information of China (English)

    M.H.M. Moussa; Rehab M. El-Shiekh

    2011-01-01

    Based on the closed connections among the homogeneous balance (HB) method and Clarkson-Kruskal (CK) method, we study the similarity reductions of the generalized variable coefficients 2D KdV equation. In the meantime it is shown that this leads to a direct reduction in the form of ordinary differential equation under some integrability conditions between the variable coefficients. Two different cases have been discussed, the search for solutions of those ordinary differential equations yielded many exact travelling and solitonic wave solutions in the form of hyperbolic and trigonometric functions under some constraints between the variable coefficients.

  20. RESEARCH ON THE COMPANION SOLUTION FOR A THIN PLATE IN THE MESHLESS LOCAL BOUNDARY INTEGRAL EQUATION METHOD

    Institute of Scientific and Technical Information of China (English)

    龙述尧; 熊渊博

    2004-01-01

    The meshless local boundary integral equation method is a currently developed numerical method, which combines the advantageous features of Galerkin finite element method(GFEM), boundary element method(BEM) and element free Galerkin method(EFGM), and is a truly meshless method possessing wide prospects in engineering applications.The companion solution and all the other formulas required in the meshless local boundary integral equation for a thin plate were presented, in order to make this method apply to solve the thin plate problem.

  1. Significance of Tribocorrosion in Biomedical Applications: Overview and Current Status

    Directory of Open Access Journals (Sweden)

    M. T. Mathew

    2009-01-01

    Full Text Available Recently, “tribocorrosion,” a research area combining the science of tribology and corrosion, has drawn attention from scientists and engineers belonging to a wide spectrum of research domains. This is due to its practical impact on daily life and also the accompanying economical burdens. It encompasses numerous applications including the offshore, space, and biomedical industry, for instance, in the case of artificial joints (Total Hip Replacement, THR in orthopedic surgery, where implant metals are constantly exposed to tribological events (joint articulations in the presence of corrosive solutions, that is, body fluids. Keeping the importance of this upcoming area of research in biomedical applications in mind, it was thought to consolidate the work in this area with some fundamental aspects so that a comprehensive picture of the current state of knowledge can be depicted. Complexity of tribocorrosion processes has been highlighted, as it is influenced by several parameters (mechanical and corrosion and also due to the lack of an integrated/efficient test system. Finally a review of the recent work in the area of biotribocorrosion is provided, by focusing on orthopedic surgery and dentistry.

  2. Solution of multi-center molecular integrals of Slater-type orbitals

    Science.gov (United States)

    Tai, H.

    1989-01-01

    The troublesome multi-center molecular integrals of Slater-type orbitals (STO) in molecular physics calculations can be evaluated by using the Fourier transform and proper coupling of the two center exchange integrals. A numerical integration procedure is then readily rendered to the final expression in which the integrand consists of well known special functions of arguments containing the geometrical arrangement of the nuclear centers and the exponents of the atomic orbitals. A practical procedure was devised for the calculation of a general multi-center molecular integrals coupling arbitrary Slater-type orbitals. Symmetry relations and asymptotic conditions are discussed. Explicit expressions of three-center one-electron nuclear-attraction integrals and four-center two-electron repulsion integrals for STO of principal quantum number n=2 are listed. A few numerical results are given for the purpose of comparison.

  3. Biomedical Engineering in Modern Society

    Science.gov (United States)

    Attinger, E. O.

    1971-01-01

    Considers definition of biomedical engineering (BME) and how biomedical engineers should be trained. State of the art descriptions of BME and BME education are followed by a brief look at the future of BME. (TS)

  4. DF积分的解法研究%Research on the Solution Method of DF Integral

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    We introduce the basic conceptions of DF integral in this paper. And based on the conception,we research on basic theories of DF integral further. Our research provides the foundation of the basic theory frame of DF integral. It helps other scholars to research DF system. In addition ,it enriches and develops the basic content of the DF Set. Therefore,the research achievement of the paper plays a stimulative role in DF system theory research.

  5. Periodic wave solutions of coupled integrable dispersionless equations by residue harmonic balance

    Science.gov (United States)

    Leung, A. Y. T.; Yang, H. X.; Guo, Z. J.

    2012-11-01

    We introduce the residue harmonic balance method to generate periodic solutions for nonlinear evolution equations. A PDE is firstly transformed into an associated ODE by a wave transformation. The higher-order approximations to the angular frequency and periodic solution of the ODE are obtained analytically. To improve the accuracy of approximate solutions, the unbalanced residues appearing in harmonic balance procedure are iteratively considered by introducing an order parameter to keep track of the various orders of approximations and by solving linear equations. Finally, the periodic solutions of PDEs result. The proposed method has the advantage that the periodic solutions are represented by Fourier functions rather than the sophisticated implicit functions as appearing in most methods.

  6. Holography In Biomedical Sciences

    Science.gov (United States)

    von Bally, G.

    1988-01-01

    Today not only physicists and engineers but also biological and medical scientists are exploring the potentials of holographic methods in their special field of work. Most of the underlying physical principles such as coherence, interference, diffraction and polarization as well as general features of holography e.g. storage and retrieval of amplitude and phase of a wavefront, 3-d-imaging, large field of depth, redundant storage of information, spatial filtering, high-resolving, non-contactive, 3-d form and motion analysis are explained in detail in other contributions to this book. Therefore, this article is confined to the applications of holography in biomedical sciences. Because of the great number of contributions and the variety of applications [1,2,3,4,5,6,7,8] in this review the investigations can only be mentioned briefly and the survey has to be confined to some examples. As in all fields of optics and laser metrology, a review of biomedical applications of holography would be incomplete if military developments and their utilization are not mentioned. As will be demonstrated by selected examples the increasing interlacing of science with the military does not stop at domains that traditionally are regarded as exclusively oriented to human welfare like biomedical research [9]. This fact is actually characterized and stressed by the expression "Star Wars Medicine", which becomes increasingly common as popular description for laser applications (including holography) in medicine [10]. Thus, the consequence - even in such highly specialized fields like biomedical applications of holography - have to be discussed.

  7. What is biomedical informatics?

    Science.gov (United States)

    Bernstam, Elmer V; Smith, Jack W; Johnson, Todd R

    2010-02-01

    Biomedical informatics lacks a clear and theoretically-grounded definition. Many proposed definitions focus on data, information, and knowledge, but do not provide an adequate definition of these terms. Leveraging insights from the philosophy of information, we define informatics as the science of information, where information is data plus meaning. Biomedical informatics is the science of information as applied to or studied in the context of biomedicine. Defining the object of study of informatics as data plus meaning clearly distinguishes the field from related fields, such as computer science, statistics and biomedicine, which have different objects of study. The emphasis on data plus meaning also suggests that biomedical informatics problems tend to be difficult when they deal with concepts that are hard to capture using formal, computational definitions. In other words, problems where meaning must be considered are more difficult than problems where manipulating data without regard for meaning is sufficient. Furthermore, the definition implies that informatics research, teaching, and service should focus on biomedical information as data plus meaning rather than only computer applications in biomedicine.

  8. Anatomy for Biomedical Engineers

    Science.gov (United States)

    Carmichael, Stephen W.; Robb, Richard A.

    2008-01-01

    There is a perceived need for anatomy instruction for graduate students enrolled in a biomedical engineering program. This appeared especially important for students interested in and using medical images. These students typically did not have a strong background in biology. The authors arranged for students to dissect regions of the body that…

  9. Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution?

    Directory of Open Access Journals (Sweden)

    Anja Ehrhardt

    2009-12-01

    Full Text Available The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based on these findings major improvements in vector design including the development of viral hybrid vectors for somatic integration have been achieved. This review provides a state-of-the-art overview of available hybrid vectors utilizing viruses for high transduction efficiencies in concert with various integration machineries for random and targeted integration patterns. It discusses advantages but also limitations of each vector system.

  10. Hooke's Atom in an Arbitrary External Electric Field: Analytical Solutions of Two-Electron Problem by Path Integral Approach

    Institute of Scientific and Technical Information of China (English)

    CAI Liang; ZHANG Ping; YANG Tao; PAN Xiao-Yin

    2011-01-01

    By using the path integral approach, we investigate the problem of Hooke's atom (two electrons interacting with Coulomb potential in an external harmonic-oscillator potential) in an arbitrary time-dependent electric field. For a certain infinite set of discrete oscillator frequencies, we obtain the analytical solutions. The ground state polarization of the atom is then calculated. The same result is also obtained through linear response theory.

  11. From bell-shaped solitary wave to W/M-shaped solitary wave solutions in an integrable nonlinear wave equation

    Indian Academy of Sciences (India)

    Aiyong Chen; Jibin Li; Chunhai Li; Yuanduo Zhang

    2010-01-01

    The bifurcation theory of dynamical systems is applied to an integrable non-linear wave equation. As a result, it is pointed out that the solitary waves of this equation evolve from bell-shaped solitary waves to W/M-shaped solitary waves when wave speed passes certain critical wave speed. Under different parameter conditions, all exact explicit parametric representations of solitary wave solutions are obtained.

  12. Solution to the Volterra integral equations of the first kind with piecewise continuous kernels in class of Sobolev-Schwartz distributions

    CERN Document Server

    Sidorov, Denis

    2012-01-01

    Sufficient conditions for existence and uniqueness of the solution of the Volterra integral equations of the first kind with piecewise continuous kernels are derived in framework of Sobolev-Schwartz distribution theory. The asymptotic approximation of the parametric family of generalized solutions is constructed. The method for the solution's regular part refinement is proposed using the successive approximations method.

  13. Cell mechanics in biomedical cavitation

    Science.gov (United States)

    Wang, Qianxi; Manmi, Kawa; Liu, Kuo-Kang

    2015-01-01

    Studies on the deformation behaviours of cellular entities, such as coated microbubbles and liposomes subject to a cavitation flow, become increasingly important for the advancement of ultrasonic imaging and drug delivery. Numerical simulations for bubble dynamics of ultrasound contrast agents based on the boundary integral method are presented in this work. The effects of the encapsulating shell are estimated by adapting Hoff's model used for thin-shell contrast agents. The viscosity effects are estimated by including the normal viscous stress in the boundary condition. In parallel, mechanical models of cell membranes and liposomes as well as state-of-the-art techniques for quantitative measurement of viscoelasticity for a single cell or coated microbubbles are reviewed. The future developments regarding modelling and measurement of the material properties of the cellular entities for cutting-edge biomedical applications are also discussed. PMID:26442142

  14. Block-pulse functions approach to numerical solution of Abel’s integral equation

    Directory of Open Access Journals (Sweden)

    Monireh Nosrati Sahlan

    2015-12-01

    Full Text Available This study aims to present a computational method for solving Abel’s integral equation of the second kind. The introduced method is based on the use of Block-pulse functions (BPFs via collocation method. Abel’s integral equations as singular Volterra integral equations are hard and heavy in computation, but because of the properties of BPFs, as is reported in examples, this method is more efficient and more accurate than some other methods for solving this class of integral equations. On the other hand, the benefit of this method is low cost of computing operations. The applied method transforms the singular integral equation into triangular linear algebraic system that can be solved easily. An error analysis is worked out and applications are demonstrated through illustrative examples.

  15. A 6.45 μW Self-Powered SoC With Integrated Energy-Harvesting Power Management and ULP Asymmetric Radios for Portable Biomedical Systems.

    Science.gov (United States)

    Roy, Abhishek; Klinefelter, Alicia; Yahya, Farah B; Chen, Xing; Gonzalez-Guerrero, Luisa Patricia; Lukas, Christopher J; Kamakshi, Divya Akella; Boley, James; Craig, Kyle; Faisal, Muhammad; Oh, Seunghyun; Roberts, Nathan E; Shakhsheer, Yousef; Shrivastava, Aatmesh; Vasudevan, Dilip P; Wentzloff, David D; Calhoun, Benton H

    2015-12-01

    This paper presents a batteryless system-on-chip (SoC) that operates off energy harvested from indoor solar cells and/or thermoelectric generators (TEGs) on the body. Fabricated in a commercial 0.13 μW process, this SoC sensing platform consists of an integrated energy harvesting and power management unit (EH-PMU) with maximum power point tracking, multiple sensing modalities, programmable core and a low power microcontroller with several hardware accelerators to enable energy-efficient digital signal processing, ultra-low-power (ULP) asymmetric radios for wireless transmission, and a 100 nW wake-up radio. The EH-PMU achieves a peak end-to-end efficiency of 75% delivering power to a 100 μA load. In an example motion detection application, the SoC reads data from an accelerometer through SPI, processes it, and sends it over the radio. The SPI and digital processing consume only 2.27 μW, while the integrated radio consumes 4.18 μW when transmitting at 187.5 kbps for a total of 6.45 μW.

  16. A Comprehensive Surface Mount Technology Solution for Integrated Circuits onto Flexible Screen Printed Electrical Interconnects

    Science.gov (United States)

    2014-05-19

    16 IV. Surface Mount Technolgy Solution: Methods of Reliability Testing...Rodolfo Milito, Jiang Zhu and Sateesh Addepalli, “Fog computing and its role in the internet of things”, in Proceedings of the MCC workshop on Mobile

  17. Integrated Systems for NGS Data Management and Analysis: Open Issues and Available Solutions.

    Science.gov (United States)

    Bianchi, Valerio; Ceol, Arnaud; Ogier, Alessandro G E; de Pretis, Stefano; Galeota, Eugenia; Kishore, Kamal; Bora, Pranami; Croci, Ottavio; Campaner, Stefano; Amati, Bruno; Morelli, Marco J; Pelizzola, Mattia

    2016-01-01

    Next-generation sequencing (NGS) technologies have deeply changed our understanding of cellular processes by delivering an astonishing amount of data at affordable prices; nowadays, many biology laboratories have already accumulated a large number of sequenced samples. However, managing and analyzing these data poses new challenges, which may easily be underestimated by research groups devoid of IT and quantitative skills. In this perspective, we identify five issues that should be carefully addressed by research groups approaching NGS technologies. In particular, the five key issues to be considered concern: (1) adopting a laboratory management system (LIMS) and safeguard the resulting raw data structure in downstream analyses; (2) monitoring the flow of the data and standardizing input and output directories and file names, even when multiple analysis protocols are used on the same data; (3) ensuring complete traceability of the analysis performed; (4) enabling non-experienced users to run analyses through a graphical user interface (GUI) acting as a front-end for the pipelines; (5) relying on standard metadata to annotate the datasets, and when possible using controlled vocabularies, ideally derived from biomedical ontologies. Finally, we discuss the currently available tools in the light of these issues, and we introduce HTS-flow, a new workflow management system conceived to address the concerns we raised. HTS-flow is able to retrieve information from a LIMS database, manages data analyses through a simple GUI, outputs data in standard locations and allows the complete traceability of datasets, accompanying metadata and analysis scripts.

  18. Integrated systems for NGS data management and analysis: open issues and available solutions

    Directory of Open Access Journals (Sweden)

    Valerio eBianchi

    2016-05-01

    Full Text Available Next-generation sequencing (NGS technologies have deeply changed our understanding of cellular processes by delivering an astonishing amount of data at affordable prices; nowadays, many biology laboratories have already accumulated a large number of sequenced samples. However, managing and analyzing these data poses new challenges, which may easily be underestimated by research groups devoid of IT and quantitative skills. In this perspective, we identify five issues that should be carefully addressed by research groups approaching NGS technologies. In particular, the five key issues to be considered concern: 1 adopting a laboratory management system (LIMS and safeguard the resulting raw data structure in downstream analyses; 2 monitoring the flow of the data and standardizing input and output directories and file names, even when multiple analysis protocols are used on the same data; 3 ensuring complete traceability of the analysis performed; 4 enabling non-experienced users to run analyses through a graphical user interface (GUI acting as a front-end for the pipelines; 5 relying on standard metadata to annotate the datasets, and when possible using controlled vocabularies, ideally derived from biomedical ontologies. Finally, we discuss the currently available tools in the light of these issues, and we introduce HTS-flow, a new workflow management system (WMS conceived to address the concerns we raised. HTS-flow is able to retrieve information from a LIMS database, manages data analyses through a simple GUI, outputs data in standard locations and allows the complete traceability of datasets, accompanying metadata and analysis scripts.

  19. Creating an Energy Intelligent Campus: Data Integration Challenges and Solutions at a Large Research Campus

    Energy Technology Data Exchange (ETDEWEB)

    Cutler, Dylan; Frank, Stephen; Slovensky, Michelle; Sheppy, Michael; Petersen, Anya

    2016-08-26

    Rich, well-organized building performance and energy consumption data enable a host of analytic capabilities for building owners and operators, from basic energy benchmarking to detailed fault detection and system optimization. Unfortunately, data integration for building control systems is challenging and costly in any setting. Large portfolios of buildings--campuses, cities, and corporate portfolios--experience these integration challenges most acutely. These large portfolios often have a wide array of control systems, including multiple vendors and nonstandard communication protocols. They typically have complex information technology (IT) networks and cybersecurity requirements and may integrate distributed energy resources into their infrastructure. Although the challenges are significant, the integration of control system data has the potential to provide proportionally greater value for these organizations through portfolio-scale analytics, comprehensive demand management, and asset performance visibility. As a large research campus, the National Renewable Energy Laboratory (NREL) experiences significant data integration challenges. To meet them, NREL has developed an architecture for effective data collection, integration, and analysis, providing a comprehensive view of data integration based on functional layers. The architecture is being evaluated on the NREL campus through deployment of three pilot implementations.

  20. The theory of bio-medical knowledge integration(v)--The meta-dimensions and their combinations of the General Linkage/Modifiers of SNOMED

    Institute of Scientific and Technical Information of China (English)

    BAO Han-fei

    2005-01-01

    From the integrated view of cognitive and noetic sciences, a set of meta-dimensions and their combinations, covering almost all of general linkage and modifiers of SNOMED, has been presented. Some examples for reasoning and operating for this set have been illustrated. Therefore the article has proved theoretically that it is possible to significantly increase the abilities of reasoning or operating and being-understood by computer in data mining of EMR, etc for a terminology system including relation(or linkage) or restriction (or modifier) items such as SNOMED. It is believed also the realizations of these tasks expected by this article are not difficult in technologic aspects for the modern software and data base technologies and the good IT engineers.

  1. Biomedical signals, imaging, and informatics

    CERN Document Server

    Bronzino, Joseph D

    2014-01-01

    Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering.Biomedical Signals, Imaging, and Informatics, the third volume of the handbook, presents material from respected scientists with diverse backgrounds in biosignal processing, medical imaging, infrared imaging, and medical informatics.More than three dozen specific topics are examined, including biomedical s

  2. Distributed Storage Inverter and Legacy Generator Integration Plus Renewables Solution for Microgrids

    Science.gov (United States)

    2015-07-01

    with small-scale power storage can maintain power quality in islanded mode with minimal use of the generators during non-optimal (e.g. cloud covered...inverter ( advantage of short term storage ) and enables microgrid upgrade of legacy generator assets (integration of inverter and generator controllers...microgrid stability, and can further be integrated with the distributed power storage to address intermittent loss of PV energy as when a cloud passes

  3. Solution of two-dimensional Fredholm integral equation via RBF-triangular method

    Directory of Open Access Journals (Sweden)

    Amir Fallahzadeh

    2012-04-01

    Full Text Available In this paper, a new method is introduced to solve a two-dimensional Fredholm integral equation. The method is based on the approximation by Gaussian radial basis functions and triangular nodes and weights. Also, a new quadrature is introduced to approximate the two dimensional integrals which is called the triangular method. The results of the example illustrate the accuracy of the proposed method increases.

  4. Production and Biomedical Applications of Probiotic Biosurfactants.

    Science.gov (United States)

    Fariq, Anila; Saeed, Ayesha

    2016-04-01

    Biosurfactants have been widely used for environmental and industrial applications. However, their use in medical field is still limited. Probiotic biosurfactants possess an immense antimicrobial, anti-adhesive, antitumor, and antibiofilm potential. Moreover, they have an additional advantage over conventional microbial surfactants because probiotics are an integral part of normal human microflora and their biosurfactants are innocuous to human. So, they can be effectively exploited for medicinal use. Present review is aimed to discourse the production and biomedical applications of probiotic biosurfactants.

  5. Zapping biomedical waste

    Energy Technology Data Exchange (ETDEWEB)

    Strack, T.

    1997-08-01

    Advances made in the use of microwave radiation techniques in the disinfection and disposal of biomedical wastes were discussed. Commercial-scale microwave disinfection methods have been developed in Germany and brought to North America in 1990. Since then some 30 hospitals in the U.S. and one in Canada have adopted the system. Details of the technology and its several operational benefits such as reduced costs, higher productivity, enhanced quality, and environmentally superior attributes, were described. The only Canadian installation is currently being operated by MEDispose Inc., as an independent, commercial biomedical treatment facility. It serves all of the southern Ontario region. Other Canadian provinces are expected to embrace the technology following extensive information dissemination about the Toronto project by the Canadian Electricity Association.

  6. Sharing big biomedical data.

    Science.gov (United States)

    Toga, Arthur W; Dinov, Ivo D

    The promise of Big Biomedical Data may be offset by the enormous challenges in handling, analyzing, and sharing it. In this paper, we provide a framework for developing practical and reasonable data sharing policies that incorporate the sociological, financial, technical and scientific requirements of a sustainable Big Data dependent scientific community. Many biomedical and healthcare studies may be significantly impacted by using large, heterogeneous and incongruent datasets; however there are significant technical, social, regulatory, and institutional barriers that need to be overcome to ensure the power of Big Data overcomes these detrimental factors. Pragmatic policies that demand extensive sharing of data, promotion of data fusion, provenance, interoperability and balance security and protection of personal information are critical for the long term impact of translational Big Data analytics.

  7. Optical Polarizationin Biomedical Applications

    CERN Document Server

    Tuchin, Valery V; Zimnyakov, Dmitry A

    2006-01-01

    Optical Polarization in Biomedical Applications introduces key developments in optical polarization methods for quantitative studies of tissues, while presenting the theory of polarization transfer in a random medium as a basis for the quantitative description of polarized light interaction with tissues. This theory uses the modified transfer equation for Stokes parameters and predicts the polarization structure of multiple scattered optical fields. The backscattering polarization matrices (Jones matrix and Mueller matrix) important for noninvasive medical diagnostic are introduced. The text also describes a number of diagnostic techniques such as CW polarization imaging and spectroscopy, polarization microscopy and cytometry. As a new tool for medical diagnosis, optical coherent polarization tomography is analyzed. The monograph also covers a range of biomedical applications, among them cataract and glaucoma diagnostics, glucose sensing, and the detection of bacteria.

  8. Solution of a Problem Linear Plane Elasticity with Mixed Boundary Conditions by the Method of Boundary Integrals

    Directory of Open Access Journals (Sweden)

    Nahed S. Hussein

    2014-01-01

    Full Text Available A numerical boundary integral scheme is proposed for the solution to the system of …eld equations of plane. The stresses are prescribed on one-half of the circle, while the displacements are given. The considered problem with mixed boundary conditions in the circle is replaced by two problems with homogeneous boundary conditions, one of each type, having a common solution. The equations are reduced to a system of boundary integral equations, which is then discretized in the usual way, and the problem at this stage is reduced to the solution to a rectangular linear system of algebraic equations. The unknowns in this system of equations are the boundary values of four harmonic functions which define the full elastic solution and the unknown boundary values of stresses or displacements on proper parts of the boundary. On the basis of the obtained results, it is inferred that a stress component has a singularity at each of the two separation points, thought to be of logarithmic type. The results are discussed and boundary plots are given. We have also calculated the unknown functions in the bulk directly from the given boundary conditions using the boundary collocation method. The obtained results in the bulk are discussed and three-dimensional plots are given. A tentative form for the singular solution is proposed and the corresponding singular stresses and displacements are plotted in the bulk. The form of the singular tangential stress is seen to be compatible with the boundary values obtained earlier. The efficiency of the used numerical schemes is discussed.

  9. End-To-End Solution for Integrated Workload and Data Management using GlideinWMS and Globus Online

    Science.gov (United States)

    Mhashilkar, Parag; Miller, Zachary; Kettimuthu, Rajkumar; Garzoglio, Gabriele; Holzman, Burt; Weiss, Cathrin; Duan, Xi; Lacinski, Lukasz

    2012-12-01

    Grid computing has enabled scientific communities to effectively share computing resources distributed over many independent sites. Several such communities, or Virtual Organizations (VO), in the Open Science Grid and the European Grid Infrastructure use the GlideinWMS system to run complex application work-flows. GlideinWMS is a pilot-based workload management system (WMS) that creates an on-demand, dynamically-sized overlay Condor batch system on Grid resources. While the WMS addresses the management of compute resources, however, data management in the Grid is still the responsibility of the VO. In general, large VOs have resources to develop complex custom solutions, while small VOs would rather push this responsibility to the infrastructure. The latter requires a tight integration of the WMS and the data management layers, an approach still not common in modern Grids. In this paper we describe a solution developed to address this shortcoming in the context of Center for Enabling Distributed Peta-scale Science (CEDPS) by integrating GlideinWMS with Globus Online (GO). Globus Online is a fast, reliable file transfer service that makes it easy for any user to move data. The solution eliminates the need for the users to provide custom data transfer solutions in the application by making this functionality part of the GlideinWMS infrastructure. To achieve this, GlideinWMS uses the file transfer plug-in architecture of Condor. The paper describes the system architecture and how this solution can be extended to support data transfer services other than Globus Online when used with Condor or GlideinWMS.

  10. Adaptive Biomedical Innovation.

    Science.gov (United States)

    Honig, P K; Hirsch, G

    2016-12-01

    Adaptive Biomedical Innovation (ABI) is a multistakeholder approach to product and process innovation aimed at accelerating the delivery of clinical value to patients and society. ABI offers the opportunity to transcend the fragmentation and linearity of decision-making in our current model and create a common collaborative framework that optimizes the benefit and access of new medicines for patients as well as creating a more sustainable innovation ecosystem.

  11. Multilingual biomedical dictionary.

    Science.gov (United States)

    Daumke, Philipp; Markó, Kornél; Poprat, Michael; Schulz, Stefan

    2005-01-01

    We present a unique technique to create a multilingual biomedical dictionary, based on a methodology called Morpho-Semantic indexing. Our approach closes a gap caused by the absence of free available multilingual medical dictionaries and the lack of accuracy of non-medical electronic translation tools. We first explain the underlying technology followed by a description of the dictionary interface, which makes use of a multilingual subword thesaurus and of statistical information from a domain-specific, multilingual corpus.

  12. [Biomedical activity of biosurfactants].

    Science.gov (United States)

    Krasowska, Anna

    2010-07-23

    Biosurfactants, amphiphilic compounds, synthesized by microorganisms have surface, antimicrobial and antitumor properties. Biosurfactants prevent adhesion and biofilms formation by bacteria and fungi on various surfaces. For many years microbial surfactants are used as antibiotics with board spectrum of activity against microorganisms. Biosurfactants act as antiviral compounds and their antitumor activities are mediated through induction of apoptosis. This work presents the current state of knowledge related to biomedical activity of biosurfactants.

  13. Iterative method for the numerical solution of a system of integral equations for the heat conduction initial boundary value problem

    Science.gov (United States)

    Svetushkov, N. N.

    2016-11-01

    The paper deals with a numerical algorithm to reduce the overall system of integral equations describing the heat transfer process at any geometrically complex area (both twodimensional and three-dimensional), to the iterative solution of a system of independent onedimensional integral equations. This approach has been called "string method" and has been used to solve a number of applications, including the problem of the detonation wave front for the calculation of heat loads in pulse detonation engines. In this approach "the strings" are a set of limited segments parallel to the coordinate axes, into which the whole solving area is divided (similar to the way the strings are arranged in a tennis racket). Unlike other grid methods where often for finding solutions, the values of the desired function in the region located around a specific central point here in each iteration step is determined by the solution throughout the length of the one-dimensional "string", which connects the two end points and set them values and determine the temperature distribution along all the strings in the first step of an iterative procedure.

  14. Approximate Formulation and Numerical Solution for Hypersingular Boundary Integral Equations in Plane Elasticity

    Institute of Scientific and Technical Information of China (English)

    马杭; 黄兴

    2003-01-01

    Based on the fact that the singular boundary integrals in the sense of Cauchy principal value can be represented approxi-mately by the mean values of two companion nearly singular boundary integrals, a vary general approach was developed in the paper.In the approach, the approximate formulation before discretization was constructed to cope with the difficulties encountered in the cor-ner treatment in the formulations of hypersingular boundary integral equations. This makes it possible to solve the hypersingular boundary integral equation numerically in a non-regularized form and in a local manner by using conforming C0 quadratic boundary ele-ments and standard Gaussian quadratures similar to those employed in the conventional displacement-BIE formulations. The approxi-mate formulation is very convenient to use because the corner information is comprised naturally in the representations of those ap-proximate integrals. Numerical examples in plane elasticity show that with the present approach, the compatible or better results can be achieved in comparison with those of the conventional BIE formulations.

  15. Cloud Based Metalearning System for Predictive Modeling of Biomedical Data

    Directory of Open Access Journals (Sweden)

    Milan Vukićević

    2014-01-01

    Full Text Available Rapid growth and storage of biomedical data enabled many opportunities for predictive modeling and improvement of healthcare processes. On the other side analysis of such large amounts of data is a difficult and computationally intensive task for most existing data mining algorithms. This problem is addressed by proposing a cloud based system that integrates metalearning framework for ranking and selection of best predictive algorithms for data at hand and open source big data technologies for analysis of biomedical data.

  16. Space-time domain solutions of the wave equation by a non-singular boundary integral method and Fourier transform.

    Science.gov (United States)

    Klaseboer, Evert; Sepehrirahnama, Shahrokh; Chan, Derek Y C

    2017-08-01

    The general space-time evolution of the scattering of an incident acoustic plane wave pulse by an arbitrary configuration of targets is treated by employing a recently developed non-singular boundary integral method to solve the Helmholtz equation in the frequency domain from which the space-time solution of the wave equation is obtained using the fast Fourier transform. The non-singular boundary integral solution can enforce the radiation boundary condition at infinity exactly and can account for multiple scattering effects at all spacings between scatterers without adverse effects on the numerical precision. More generally, the absence of singular kernels in the non-singular integral equation confers high numerical stability and precision for smaller numbers of degrees of freedom. The use of fast Fourier transform to obtain the time dependence is not constrained to discrete time steps and is particularly efficient for studying the response to different incident pulses by the same configuration of scatterers. The precision that can be attained using a smaller number of Fourier components is also quantified.

  17. Economic Evaluation of Three Available Solutions for Promotion of Wind Power Integration

    Directory of Open Access Journals (Sweden)

    Hong-Kun Chen

    2017-01-01

    Full Text Available The limited operational flexibility of combined heat and power (CHP units is the main cause of wind power curtailment in the thermal-electrical power system of Northern China. Pumped hydrostorage (PHS, heat storage (HS, and electric boiler (EB are investigated as three alternative options for the promotion of wind power integration. On the basis of two linear models that determine the capacities of these three facilities required for integrating the curtailed wind power, economic evaluation in terms of investment costs and environmental benefits is presented. Analysis results show that HS requires the least investment and has a good performance of coal saving when accommodating the same amount of curtailed wind power. And EB has the greatest potential for wind power integration with the huge growth of installed capacity of wind power in the future.

  18. Convex integration theory solutions to the h-principle in geometry and topology

    CERN Document Server

    Spring, David

    1998-01-01

    This book provides a comprehensive study of convex integration theory in immersion-theoretic topology. Convex integration theory, developed originally by M. Gromov, provides general topological methods for solving the h-principle for a wide variety of problems in differential geometry and topology, with applications also to PDE theory and to optimal control theory. Though topological in nature, the theory is based on a precise analytical approximation result for higher order derivatives of functions, proved by M. Gromov. This book is the first to present an exacting record and exposition of all of the basic concepts and technical results of convex integration theory in higher order jet spaces, including the theory of iterated convex hull extensions and the theory of relative h-principles. A second feature of the book is its detailed presentation of applications of the general theory to topics in symplectic topology, divergence free vector fields on 3-manifolds, isometric immersions, totally real embeddings, u...

  19. On solution of the integral equations for the potential problems of two circular-strips

    Directory of Open Access Journals (Sweden)

    C. Sampath

    1988-01-01

    Dirichlet and Newmann boundary value problems of two equal infinite coaxial circular strips in various branches of potential theory. For illustration, these solutions are applied to solve some boundary value problems in electrostatics, hydrodynamics, and expressions for the physical quantities of interest are derived.

  20. Exact solutions to the Boltzmann equation by mapping the scattering integral into a differential operator

    Energy Technology Data Exchange (ETDEWEB)

    Zabadal, Jorge; Borges, Volnei; Van der Laan, Flavio T., E-mail: jorge.zabadal@ufrgs.br, E-mail: borges@ufrgs.br, E-mail: ftvdl@ufrgs.br [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil). Departamento de Engenharia Mecanica. Grupo de Pesquisas Radiologicas; Ribeiro, Vinicius G., E-mail: vinicius_ribeiro@uniritter.edu.br [Centro Universitario Ritter dos Reis (UNIRITTER), Porto Alegre, RS (Brazil); Santos, Marcio G., E-mail: phd.marcio@gmail.com [Universidade Federal do Rio Grande do Sul (UFRGS), Tramandai, RS (Brazil). Departamento Interdisciplinar do Campus Litoral Norte

    2015-07-01

    This work presents a new analytical method for solving the Boltzmann equation. In this formulation, a linear differential operator is applied over the Boltzmann model, in order to produce a partial differential equation in which the scattering term is absent. This auxiliary equation is solved via reduction of order. The exact solution obtained is employed to define a precursor for the buildup factor. (author)

  1. Quadrature Rules and Iterative Method for Numerical Solution of Two-Dimensional Fuzzy Integral Equations

    Directory of Open Access Journals (Sweden)

    S. M. Sadatrasoul

    2014-01-01

    Full Text Available We introduce some generalized quadrature rules to approximate two-dimensional, Henstock integral of fuzzy-number-valued functions. We also give error bounds for mappings of bounded variation in terms of uniform modulus of continuity. Moreover, we propose an iterative procedure based on quadrature formula to solve two-dimensional linear fuzzy Fredholm integral equations of the second kind (2DFFLIE2, and we present the error estimation of the proposed method. Finally, some numerical experiments confirm the theoretical results and illustrate the accuracy of the method.

  2. Crossing the Chasm: Information Technology to Biomedical Informatics

    Science.gov (United States)

    Fahy, Brenda G.; Balke, C. William; Umberger, Gloria H.; Talbert, Jeffery; Canales, Denise Niles; Steltenkamp, Carol L.; Conigliaro, Joseph

    2011-01-01

    Accelerating the translation of new scientific discoveries to improve human health and disease management is the overall goal of a series of initiatives integrated in the National Institutes of Health (NIH) “Roadmap for Medical Research.” The Clinical and Translational Research Award (CTSA) program is, arguably, the most visible component of the NIH Roadmap providing resources to institutions to transform their clinical and translational research enterprises along the goals of the Roadmap. The CTSA program emphasizes biomedical informatics as a critical component for the accomplishment of the NIH’s translational objectives. To be optimally effective, emerging biomedical informatics programs must link with the information technology (IT) platforms of the enterprise clinical operations within academic health centers. This report details one academic health center’s transdisciplinary initiative to create an integrated academic discipline of biomedical informatics through the development of its infrastructure for clinical and translational science infrastructure and response to the CTSA mechanism. This approach required a detailed informatics strategy to accomplish these goals. This transdisciplinary initiative was the impetus for creation of a specialized biomedical informatics core, the Center for Biomedical Informatics (CBI). Development of the CBI codified the need to incorporate medical informatics including quality and safety informatics and enterprise clinical information systems within the CBI. This paper describes the steps taken to develop the biomedical informatics infrastructure, its integration with clinical systems at one academic health center, successes achieved, and barriers encountered during these efforts. PMID:21383632

  3. Why go via expensive solutions, when you can GoDirect? a description of how CERN Library integrates digital content

    CERN Document Server

    Vigen, Jens

    2004-01-01

    In the digital world the creative solutions have to be implemented far quicker than what was required in the era of printed publications. In such a context many vendors take advantage and offer the library community simple computer applications to outrageous prices as if the products were highly sophisticated information systems that would be impossible to develop and maintain in-house. The CERN Scientific information Service has chosen not to join this game, partly due to that commercial solutions were not available at the time when first needed, partly due to that lots of the solutions actually can be implemented and run with already available resources within the library and the informatics support. Using only inhouse developed solutions, digital content at CERN is today being integrated to the highest possible level in order to meet the high requirements of the particle physics community. The paper gives an overview of the steps CERN has made towards the digital library from the day the laboratory conceiv...

  4. Type I integrable defects and finite-gap solutions for KdV and sine-Gordon models

    Science.gov (United States)

    Corrigan, E.; Parini, R.

    2017-07-01

    The main purpose of this paper is to extend results, which have been obtained previously to describe the classical scattering of solitons with integrable defects of type I, to include the much larger and intricate collection of finite-gap solutions defined in terms of generalised theta functions. In this context, it is generally not feasible to adopt a direct approach, via ansätze for the fields to either side of the defect tuned to satisfy the defect sewing conditions. Rather, essential use is made of the fact that the defect sewing conditions themselves are intimately related to Bäcklund transformations in order to set up a strategy to enable the calculation of the field on one side by suitably transforming the field on the other side. The method is implemented using Darboux transformations and illustrated in detail for the sine-Gordon and KdV models. An exception, treatable by both methods, indirect and direct, is provided by the genus 1 solutions. These can be expressed in terms of Jacobi elliptic functions, which satisfy a number of useful identities of relevance to this problem. There are new features to the solutions obtained in the finite-gap context but, in all cases, if a (multi)soliton limit is taken within the finite-gap solutions previously known results are recovered.

  5. Painlevé analysis, integrability and exact solutions for a (2 + 1)-dimensional generalized Nizhnik-Novikov-Veselov equation

    Science.gov (United States)

    Xu, Gui-Qiong; Deng, Shu-Fang

    2016-11-01

    Under investigation in this paper is a (2 + 1)-dimensional generalized NNV equation, which includes as many important nonlinear models as its particular cases. First, we perform the Painlevé test for the generalized NNV equation with the help of symbolic computation, and it is shown that this generalized equation admits the Painlevé property for one set of parametric choices. For the newly obtained integrable equation, we then employ the binary Bell polynomial method to construct the bilinear form, N-soliton solution, bilinear Bäcklund transformation and Lax pair in a systematic way. In addition, some new doubly periodic wave solutions with two arbitrary functions are obtained by means of truncated Painlevé expansions. Finally, the collisions of multiple solitons and periodic waves are interesting and shown by some graphs.

  6. End-To-End Solution for Integrated Workload and Data Management using glideinWMS and Globus Online

    CERN Document Server

    CERN. Geneva

    2012-01-01

    Grid computing has enabled scientific communities to effectively share computing resources distributed over many independent sites. Several such communities, or Virtual Organizations (VO), in the Open Science Grid and the European Grid Infrastructure use the glideinWMS system to run complex application work-flows. GlideinWMS is a pilot-based workload management system (WMS) that creates on demand, dynamically-sized overlay Condor batch system on Grid resources. While the WMS addresses the management of compute resources, however, data management in the Grid is still the responsibility of the VO. In general, large VOs have resources to develop complex custom solutions, while small VOs would rather push this responsibility to the infrastructure. The latter requires a tight integration of the WMS and the data management layers, an approach still not common in modern Grids. In this paper we describe a solution developed to address this shortcoming in the context of Center for Enabling Distributed Petascale Scienc...

  7. Explicit solution of the Volterra integral equation for transient fields on inhomogeneous arbitrarily shaped dielectric bodies

    KAUST Repository

    Al Jarro, Ahmed

    2011-09-01

    A new predictor-corrector scheme for solving the Volterra integral equation to analyze transient electromagnetic wave interactions with arbitrarily shaped inhomogeneous dielectric bodies is considered. Numerical results demonstrating stability and accuracy of the proposed method are presented. © 2011 IEEE.

  8. A meshless based method for solution of integral equations: Improving the error analysis

    OpenAIRE

    Mirzaei, Davoud

    2015-01-01

    This draft concerns the error analysis of a collocation method based on the moving least squares (MLS) approximation for integral equations, which improves the results of [2] in the analysis part. This is mainly a translation from Persian of some parts of Chapter 2 of the author's PhD thesis in 2011.

  9. Integrating ICTs into the Environmental Science Primary School Classroom in Chegutu District, Zimbabwe: Problems and Solutions

    Science.gov (United States)

    Shadreck, Mandina

    2015-01-01

    This study investigated primary school teachers' perceptions of the barriers and challenges preventing them from integrating ICTs in the environmental science classroom. The study adopted a qualitative research approach that is in line with the phenomenological perspective as it sought to acquire knowledge through understanding the direct…

  10. Numerical solution of integral equations, describing mass spectrum of vector mesons

    Energy Technology Data Exchange (ETDEWEB)

    Zhidkov, E.P.; Nikonov, E.G.; Sidorov, A.V.; Skachkov, N.B.; Khoromskiy, B.N.

    1988-09-22

    The description of the numerical algorithm for solving quazipotential integral equation in impulse space is presented. The results of numerical computations of the vector meson mass spectrum and the lepton decay width are given in comparison with the experimental data. 6 refs., 4 tabs.

  11. Overview of progress in European medium sized tokamaks towards an integrated plasma-edge/wall solution

    DEFF Research Database (Denmark)

    Meyer, H.; Eich, T.; Beurskens, M.

    2017-01-01

    Integrating the plasma core performance with an edge and scrape-off layer (SOL) that leads to tolerable heat and particle loads on the wall is a major challenge. The new European medium size tokamak task force (EU-MST) coordinates research on ASDEX Upgrade (AUG), MAST and TCV. This multi-machine ...

  12. Exact solution for the quench dynamics of a nested integrable system

    Science.gov (United States)

    Mestyán, Márton; Bertini, Bruno; Piroli, Lorenzo; Calabrese, Pasquale

    2017-08-01

    Integrable models provide an exact description for a wide variety of physical phenomena. For example nested integrable systems contain different species of interacting particles with a rich phenomenology in their collective behavior, which is the origin of the unconventional phenomenon of spin-charge separation. So far, however, most of the theoretical work in the study of non-equilibrium dynamics of integrable systems has focussed on models with an elementary (i.e. not nested) Bethe ansatz. In this work we explicitly investigate quantum quenches in nested integrable systems, by generalizing the application of the quench action approach. Specifically, we consider the spin-1 Lai-Sutherland model, described, in the thermodynamic limit, by the theory of two different species of Bethe-ansatz particles, each one forming an infinite number of bound states. We focus on the situation where the quench dynamics starts from a simple matrix product state for which the overlaps with the eigenstates of the Hamiltonian are known. We fully characterize the post-quench steady state and perform several consistency checks for the validity of our results. Finally, we provide predictions for the propagation of entanglement and mutual information after the quench, which can be used as signature of the quasi-particle content of the model.

  13. An Analytical Solution To A Special Case Of The Weber-Schafheitlin Integral

    CERN Document Server

    Mehrem, R

    2012-01-01

    The Weber-Schafheitlin type integral $\\threej{\\Llo}{\\Llt}{\\Llth}{0}{0}{0}\\,\\int_0^\\infty \\,{j_\\Llo(k_1r)\\,j_\\Llt(k_2r)\\over r^\\Llth}\\,dr$ is evaluated analytically. The result is a finite sum over $k_$, where $k_$) is the smaller (larger) of $k_1$ and $k_2$.

  14. Interactive radiological anatomy eLearning solution for first year medical students: Development, integration, and impact on learning.

    Science.gov (United States)

    Webb, Alexandra Louise; Choi, Sunhea

    2014-01-01

    A technology enhanced learning and teaching (TELT) solution, radiological anatomy (RA) eLearning, composed of a range of identification-based and guided learning activities related to normal and pathological X-ray images, was devised for the Year 1 nervous and locomotor course at the Faculty of Medicine, University of Southampton. Its effectiveness was evaluated using a questionnaire, pre- and post-tests, focus groups, summative assessment, and tracking data. Since introduced in 2009, a total of 781 students have used RA eLearning, and among them 167 Year 1 students in 2011, of whom 116 participated in the evaluation study. Students enjoyed learning (77%) with RA eLearning, found it was easy to use (81%) and actively engaged them in their learning (75%), all of which were associated to the usability, learning design of the TELT solution and its integration in the curriculum; 80% of students reported RA eLearning helped their revision of anatomy and 69% stated that it facilitated their application of anatomy in a clinical context, both of which were associated with the benefits offered by the learning and activities design. At the end of course summative assessment, student knowledge of RA eLearning relevant topics (mean 80%; SD ±16) was significantly better as compared to topics not relevant to RA eLearning (mean 63%; SD ±15) (mean difference 18%; 95% CI 15% to 20%; P < 0.001). A well designed and integrated TELT solution can be an efficient method for facilitating the application, integration, and contextualization of anatomy and radiology to create a blended learning environment.

  15. Dynamical Chaos in the Wisdom-Holman Integrator: Origins and Solutions

    Science.gov (United States)

    Rauch, Kevin P.; Holman, Matthew

    1999-01-01

    We examine the nonlinear stability of the Wisdom-Holman (WH) symplectic mapping applied to the integration of perturbed, highly eccentric (e-0.9) two-body orbits. We find that the method is unstable and introduces artificial chaos into the computed trajectories for this class of problems, unless the step size chosen 1s small enough that PeriaPse is always resolved, in which case the method is generically stable. This 'radial orbit instability' persists even for weakly perturbed systems. Using the Stark problem as a fiducial test case, we investigate the dynamical origin of this instability and argue that the numerical chaos results from the overlap of step-size resonances; interestingly, for the Stark-problem many of these resonances appear to be absolutely stable. We similarly examine the robustness of several alternative integration methods: a time-regularized version of the WH mapping suggested by Mikkola; the potential-splitting (PS) method of Duncan, Levison, Lee; and two original methods incorporating approximations based on Stark motion instead of Keplerian motion. The two fixed point problem and a related, more general problem are used to conduct a comparative test of the various methods for several types of motion. Among the algorithms tested, the time-transformed WH mapping is clearly the most efficient and stable method of integrating eccentric, nearly Keplerian orbits in the absence of close encounters. For test particles subject to both high eccentricities and very close encounters, we find an enhanced version of the PS method-incorporating time regularization, force-center switching, and an improved kernel function-to be both economical and highly versatile. We conclude that Stark-based methods are of marginal utility in N-body type integrations. Additional implications for the symplectic integration of N-body systems are discussed.

  16. Variable Step Integration Coupled with the Method of Characteristics Solution for Water-Hammer Analysis, A Case Study

    Science.gov (United States)

    Turpin, Jason B.

    2004-01-01

    One-dimensional water-hammer modeling involves the solution of two coupled non-linear hyperbolic partial differential equations (PDEs). These equations result from applying the principles of conservation of mass and momentum to flow through a pipe, and usually the assumption that the speed at which pressure waves propagate through the pipe is constant. In order to solve these equations for the interested quantities (i.e. pressures and flow rates), they must first be converted to a system of ordinary differential equations (ODEs) by either approximating the spatial derivative terms with numerical techniques or using the Method of Characteristics (MOC). The MOC approach is ideal in that no numerical approximation errors are introduced in converting the original system of PDEs into an equivalent system of ODEs. Unfortunately this resulting system of ODEs is bound by a time step constraint so that when integrating the equations the solution can only be obtained at fixed time intervals. If the fluid system to be modeled also contains dynamic components (i.e. components that are best modeled by a system of ODEs), it may be necessary to take extremely small time steps during certain points of the model simulation in order to achieve stability and/or accuracy in the solution. Coupled together, the fixed time step constraint invoked by the MOC, and the occasional need for extremely small time steps in order to obtain stability and/or accuracy, can greatly increase simulation run times. As one solution to this problem, a method for combining variable step integration (VSI) algorithms with the MOC was developed for modeling water-hammer in systems with highly dynamic components. A case study is presented in which reverse flow through a dual-flapper check valve introduces a water-hammer event. The predicted pressure responses upstream of the check-valve are compared with test data.

  17. Evolving technologies drive the new roles of Biomedical Engineering.

    Science.gov (United States)

    Frisch, P H; St Germain, J; Lui, W

    2008-01-01

    Rapidly changing technology coupled with the financial impact of organized health care, has required hospital Biomedical Engineering organizations to augment their traditional operational and business models to increase their role in developing enhanced clinical applications utilizing new and evolving technologies. The deployment of these technology based applications has required Biomedical Engineering organizations to re-organize to optimize the manner in which they provide and manage services. Memorial Sloan-Kettering Cancer Center has implemented a strategy to explore evolving technologies integrating them into enhanced clinical applications while optimally utilizing the expertise of the traditional Biomedical Engineering component (Clinical Engineering) to provide expanded support in technology / equipment management, device repair, preventive maintenance and integration with legacy clinical systems. Specifically, Biomedical Engineering is an integral component of the Medical Physics Department which provides comprehensive and integrated support to the Center in advanced physical, technical and engineering technology. This organizational structure emphasizes the integration and collaboration between a spectrum of technical expertise for clinical support and equipment management roles. The high cost of clinical equipment purchases coupled with the increasing cost of service has driven equipment management responsibilities to include significant business and financial aspects to provide a cost effective service model. This case study details the dynamics of these expanded roles, future initiatives and benefits for Biomedical Engineering and Memorial Sloan Kettering Cancer Center.

  18. Exact solutions of the Klein-Gordon equation with ring-shaped oscillator potential by using the Laplace integral transform

    Institute of Scientific and Technical Information of China (English)

    Sami Ortakaya

    2012-01-01

    We present exact solutions for the Klein-Gordon equation with a ring-shaped oscillator potential.The energy eigenvalues and the normalized wave functions are obtained for a particle in the presence of non-central oscillator potential.The angular functions are expressed in terms of the hypergeometric functions.The radial eigenfunctions have been obtained by using the Laplace integral transform.By means of the Laplace transform method,which is efficient and simple,the radial Klein-Gordon equation is reduced to a first-order differential equation.

  19. Symmetry Reductions, Integrability and Solitary Wave Solutions to High-Order Modified Boussinesq Equations with Damping Term

    Institute of Scientific and Technical Information of China (English)

    YAN ZhenYa; XIE FuDing; ZHANG HongQing

    2001-01-01

    Both the direct method due to Clarkson and Kruskal and the improved direct method due to Lou are extended to reduce the high-order modified Boussinesq equation with the damping term (HMBEDT) arising in the general Fermi-Pasta-Ulam model. As a result, several types of similarity reductions are obtained. It is easy to show that the nonlinear wave equation is not integrable under the sense of AblowRz's conjecture from the reduction results obtained. In addition, kink-shaped solitary wave solutions, which are of important physical significance, are found for HMBEDT based on the obtained reduction equation.``

  20. Advances in integrated and sustainable supply chain planning concepts, methods, tools and solution approaches toward a platform for industrial practice

    CERN Document Server

    Laínez-Aguirre, José Miguel

    2015-01-01

    Decision making at the enterprise level often encompass not only production operations and  product R&D, but other strategic functions such as financial planning and marketing. With the aim of maximizing growth and a firm’s value, companies often focus on co-ordinating these functional components as well as traditional hierarchical decision levels. Understanding this interplay can enhance enterprise capabilities of adaptation and response to uncertainties arising from internal processes as well as the external environment. This book presents concepts, methods, tools and solutions based on mathematical programming, which provides the quantitative support needed for integrated decision-making and ultimately for improving the allocation of overall corporate resources (e.g., materials, cash and personnel). Through a systems perspective, the integrated planning of the supply chain also promotes activities of reuse, reduction and recycling for achieving more sustainable environmental impacts of production/di...

  1. Integrability and Solutions of the (2 + 1)-dimensional Hunter-Saxton Equation

    Science.gov (United States)

    Cai, Hong-Liu; Qu, Chang-Zheng

    2016-04-01

    In this paper, the (2 + 1)-dimensional Hunter-Saxton equation is proposed and studied. It is shown that the (2 + 1)-dimensional Hunter-Saxton equation can be transformed to the Calogero-Bogoyavlenskii-Schiff equation by reciprocal transformations. Based on the Lax-pair of the Calogero-Bogoyavlenskii-Schiff equation, a non-isospectral Lax-pair of the (2 + 1)-dimensional Hunter-Saxton equation is derived. In addition, exact singular solutions with a finite number of corners are obtained. Furthermore, the (2 + 1)-dimensional μ-Hunter-Saxton equation is presented, and its exact peaked traveling wave solutions are derived. Supported by National Natural Science Foundation of China under Grant No. 11471174 and NSF of Ningbo under Grant No. 2014A610018

  2. A hybrid CMOS-imager with integrated solution-processable organic photodiodes

    OpenAIRE

    Baierl, Daniela

    2013-01-01

    The solution-processability of organic photodetectors allows a straightforward combination with other materials and technologies, including inorganic ones, without increasing cost and process complexity significantly compared to conventional crystalline semiconductors. Present CMOS-imagers exhibit a small pixel fill factor of about 30 % which decreases the light sensitivity significantly. The fill factor can be increased up to 100 % by replacing the silicon photodiodes with an organic ph...

  3. High performance flexible electronics for biomedical devices.

    Science.gov (United States)

    Salvatore, Giovanni A; Munzenrieder, Niko; Zysset, Christoph; Kinkeldei, Thomas; Petti, Luisa; Troster, Gerhard

    2014-01-01

    Plastic electronics is soft, deformable and lightweight and it is suitable for the realization of devices which can form an intimate interface with the body, be implanted or integrated into textile for wearable and biomedical applications. Here, we present flexible electronics based on amorphous oxide semiconductors (a-IGZO) whose performance can achieve MHz frequency even when bent around hair. We developed an assembly technique to integrate complex electronic functionalities into textile while preserving the softness of the garment. All this and further developments can open up new opportunities in health monitoring, biotechnology and telemedicine.

  4. Designing a Truly Integrated (Onsite and Online) Conference: Concept, Processes, Solutions

    CERN Document Server

    Botchkarev, Alexei; Rasouli, Hamed

    2010-01-01

    Web conferencing tools have entered the mainstream of business applications. Using web conferencing for IEEE conferences has a good potential of adding value to both organizers and participants. Authors propose a concept of Truly Integrated Conference (TIC) according to which a multi-point worldwide-distributed network of conference online authors/participants will enhance the standard (centralized) IEEE conference model, which requires attendance of the participants in person at the main conference location. The concept entails seamless integration of the onsite and online conference systems, including data/presentation, video, audio channels. Benefits and challenges of the TIC concept are analyzed. Requirements to the web conferencing system capable of supporting the TIC conference are presented and reviewed against commercial web conferencing tools. Case study of the IEEE Toronto International Conference ? Science and Technology for Humanity, which was the first realization of TIC, is presented which analy...

  5. A Multi-Agent Based Energy Management Solution for Integrated Buildings and Microgrid System

    DEFF Research Database (Denmark)

    Anvari-Moghaddam, Amjad; Rahimi-Kian, Ashkan; Mirian, Maryam S.

    2017-01-01

    In this paper, an ontology-driven multi-agent based energy management system (EMS) is proposed for monitoring and optimal control of an integrated homes/buildings and microgrid system with various renewable energy resources (RESs) and controllable loads. Different agents ranging from simple......-reflex to complex learning agents are designed and implemented to cooperate with each other to reach an optimal operating strategy for the mentioned integrated energy system (IES) while meeting the system’s objectives and related constraints. The optimization process for the EMS is defined as a coordinated...... distributed generation (DG) and demand response (DR) management problem within the studied environment and is solved by the proposed agent-based approach utilizing cooperation and communication among decision agents. To verify the effectiveness and applicability of the proposed multi-agent based EMS, several...

  6. Dynamical Chaos in the Wisdom-Holman Integrator Origins and Solutions

    CERN Document Server

    Rauch, K P; Rauch, Kevin P.; Holman, Matthew

    1999-01-01

    We examine the non-linear stability of the Wisdom-Holman (WH) mapping applied to the integration of perturbed, highly eccentric two-body orbits. We find that the method is unstable and introduces artificial chaos into the computed trajectories, unless the step size is chosen small enough to resolve pericenter. The origin of the instability is analyzed analytically using the Stark problem as a fiducial test case. We similarly examine the robustness of several alternative methods: a regularized WH map due to Mikkola (1997); the potential-splitting (PS) approach of Lee et al. (1997); and two types of Stark-based methods. Comparative simulations show the regularized WH map to be stable at high eccentricities, and an enhanced PS algorithm to perform well when close encounters are additionally present. We find Stark-based schemes to be of marginal use in N-body type integrations.

  7. Integrated hydrogen control solutions for severe accidents using passive autocatalytic recombiners

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, M.; Tietsch, W.; Sabate Farnos, R.

    2012-07-01

    In a severe accident or a beyond-design-basis-accident, the reaction of water with zirconium alloy cladding, radiolysis of water, corium-concrete reactions and other corrosion phenomena generate hydrogen (H2). The detonation of this H2 in containment or in auxiliary buildings can result in damage to structures or loss of containment integrity. Identifying the generation and special distribution of hydrogen and controlling its concentration with Passive Autocatalytic Recombiners (PARs) solves this concern. Westinghouse's approach for hydrogen management starts by defining the quantities and transport/distribution of H{sub 2} in-containment and out of containment with analysis tools such as MAAP, MELCOR, GASFLOW or FATE. Based on the results of these analyses, an optimized H2 Control Strategy is proposed in terms of number and location of PARs, and efficient integration with other H{sub 2} management devices like e.g. existing igniters, H{sub 2} monitors, etc.

  8. Building a biomedical ontology recommender web service.

    Science.gov (United States)

    Jonquet, Clement; Musen, Mark A; Shah, Nigam H

    2010-06-22

    Researchers in biomedical informatics use ontologies and terminologies to annotate their data in order to facilitate data integration and translational discoveries. As the use of ontologies for annotation of biomedical datasets has risen, a common challenge is to identify ontologies that are best suited to annotating specific datasets. The number and variety of biomedical ontologies is large, and it is cumbersome for a researcher to figure out which ontology to use. We present the Biomedical Ontology Recommender web service. The system uses textual metadata or a set of keywords describing a domain of interest and suggests appropriate ontologies for annotating or representing the data. The service makes a decision based on three criteria. The first one is coverage, or the ontologies that provide most terms covering the input text. The second is connectivity, or the ontologies that are most often mapped to by other ontologies. The final criterion is size, or the number of concepts in the ontologies. The service scores the ontologies as a function of scores of the annotations created using the National Center for Biomedical Ontology (NCBO) Annotator web service. We used all the ontologies from the UMLS Metathesaurus and the NCBO BioPortal. We compare and contrast our Recommender by an exhaustive functional comparison to previously published efforts. We evaluate and discuss the results of several recommendation heuristics in the context of three real world use cases. The best recommendations heuristics, rated 'very relevant' by expert evaluators, are the ones based on coverage and connectivity criteria. The Recommender service (alpha version) is available to the community and is embedded into BioPortal.

  9. Explicit solution of the time domain magnetic field integral equation using a predictor-corrector scheme

    KAUST Repository

    Ulku, Huseyin Arda

    2012-09-01

    An explicit yet stable marching-on-in-time (MOT) scheme for solving the time domain magnetic field integral equation (TD-MFIE) is presented. The stability of the explicit scheme is achieved via (i) accurate evaluation of the MOT matrix elements using closed form expressions and (ii) a PE(CE) m type linear multistep method for time marching. Numerical results demonstrate the accuracy and stability of the proposed explicit MOT-TD-MFIE solver. © 2012 IEEE.

  10. Integrated valuation of a nature-based solution for water pollution control. Highlighting hidden benefits

    OpenAIRE

    LIQUETE GARCIA MARIA DEL CAMINO; UDIAS MOINELO ANGEL; Conte, Giulio; Grizzetti, Bruna; MASI Fabio

    2015-01-01

    In this study we assess multiple benefits (environmental, social and economic) provided by a multi-purpose green infrastructure (a series of constructed wetlands surrounded by a park) in a peri-urban area, and compare it with the alternative grey infrastructure and with the previous situation (a poplar plantation). We apply a multi-criteria analysis as a basis for integrated valuation. We address specific policy needs (strategic objectives) for the local territorial planning in the implementa...

  11. INTEGRATION OF UKRAINIAN INDUSTRY SCIENTIFIC PERIODACLS INTO WORLD SCIENTIFIC INFORMATION SPACE: PROBLEMS AND SOLUTIONS

    Directory of Open Access Journals (Sweden)

    T. O. Kolesnykova

    2013-11-01

    Full Text Available Purpose. Problem of representation lack of scientists’ publications, including transport scientists, in the international scientometric databases is the urgent one for Ukrainian science. To solve the problem one should study the structure and quality of the information flow of scientific periodicals of railway universities in Ukraine and to determine the integration algorithm of scientific publications of Ukrainian scientists into the world scientific information space. Methodology. Applying the methods of scientific analysis, synthesis, analogy, comparison and prediction the author has investigated the problem of scientific knowledge distribution using formal communications. The readiness of Ukrainian railway periodicals to registration procedure in the international scientometric systems was analyzed. The level of representation of articles and authors of Ukrainian railway universities in scientometric database Scopus was studied. Findings. Monitoring of the portals of railway industry universities of Ukraine and the sites of their scientific periodicals and analysis of obtained data prove insufficient readiness of most scientific publications for submission to scientometric database. The ways providing sufficient "visibility" of industry periodicals of Ukrainian universities in the global scientific information space were proposed. Originality. The structure and quality of documentary flow of scientific periodicals in railway transport universities of Ukraine and its reflection in scientometric DB Scopus were first investigated. The basic directions of university activities to integrate the results of transport scientists research into the global scientific digital environment were outlined. It was determined the leading role of university libraries in the integration processes of scientific documentary resources of universities into the global scientific and information communicative space. Practical value. Implementation of the proposed

  12. Steps for the Solution of Faddeev Integral Equations in Configuration Space

    Directory of Open Access Journals (Sweden)

    Glöckle W.

    2010-04-01

    Full Text Available Faddeev equations in configuration space for three-atom scattering processes that have previously b een formulated in integral form allowing for additive and nonadditive forces, are now examined in terms of their numerical prop erties for a “toy-model” case. The numerical implementation is based on a sp ectral decomp osition in terms of Chebyshev p olynomials. The potential for high accuracy of this method, of the order of 6 to 8 significant figures is one of the main motivations for the present investigation.The ob ject of the equations are T-functions, that are the product of wave functions times potentials, that decay to zero in all directions. The driving and coupling terms are based on the two-body t-matrices, which describe the two-body correlations in each arrangement. The preferred form for b oth the driving term and the integral kernel terms is of a hybrid nature, the x-dependence is expanded into Chebyshev p olynomials, and the y-dependence is given in terms of a Fourier series. The numerical prop erties of the driving term are examined in detail, and the integral kernel is left for a subsequent analysis.

  13. Ensemble variance in free energy calculations by thermodynamic integration: theory, optimal "Alchemical" path, and practical solutions.

    Science.gov (United States)

    Blondel, Arnaud

    2004-05-01

    Thermodynamic integration is a widely used method to calculate and analyze the effect of a chemical modification on the free energy of a chemical or biochemical process, for example, the impact of an amino acid substitution on protein association. Numerical fluctuations can introduce large uncertainties, limiting the domain of application of the method. The parametric energy function describing the chemical modification in the thermodynamic integration, the "Alchemical path," determines the amplitudes of the fluctuations. In the present work, I propose a measure of the fluctuations in the thermodynamic integration and an approach to search for a parametric energy path minimizing that measure. The optimal path derived with this approach is very close to the theoretical minimum of the measure, but produces nonergodic sampling. Nevertheless, this path is used to guide the design of a practical and efficient path producing correct sampling. The convergence with this practical path is evaluated on test cases, and compares favorably with that of other methods such as power or polynomial path, soft-core van der Waals, and some other approaches presented in the literature.

  14. NIH Funding for Biomedical Imaging

    Science.gov (United States)

    Conroy, Richard

    Biomedical imaging, and in particular MRI and CT, is often identified as among the top 10 most significant advances in healthcare in the 20th century. This presentation will describe some of the recent advances in medical physics and imaging being funded by NIH in this century and current funding opportunities. The presentation will also highlight the role of multidisciplinary research in bringing concepts from the physical sciences and applying them to challenges in biological and biomedical research.. NIH Funding for Biomedical Imaging.

  15. BIMS: Biomedical Information Management System

    OpenAIRE

    Mora, Oscar; Bisbal, Jesús

    2013-01-01

    In this paper, we present BIMS (Biomedical Information Management System). BIMS is a software architecture designed to provide a flexible computational framework to manage the information needs of a wide range of biomedical research projects. The main goal is to facilitate the clinicians' job in data entry, and researcher's tasks in data management, in high data quality biomedical research projects. The BIMS architecture has been designed following the two-level modeling paradigm, a promising...

  16. Composite annotations: requirements for mapping multiscale data and models to biomedical ontologies

    Science.gov (United States)

    Cook, Daniel L.; Mejino, Jose L. V.; Neal, Maxwell L.; Gennari, John H.

    2009-01-01

    Current methods for annotating biomedical data resources rely on simple mappings between data elements and the contents of a variety of biomedical ontologies and controlled vocabularies. Here we point out that such simple mappings are inadequate for large-scale multiscale, multidomain integrative “virtual human” projects. For such integrative challenges, we describe a “composite annotation” schema that is simple yet sufficiently extensible for mapping the biomedical content of a variety of data sources and biosimulation models to available biomedical ontologies. PMID:19964601

  17. Biomedical photonics handbook

    CERN Document Server

    Vo-Dinh, Tuan

    2003-01-01

    1.Biomedical Photonics: A Revolution at the Interface of Science and Technology, T. Vo-DinhPHOTONICS AND TISSUE OPTICS2.Optical Properties of Tissues, J. Mobley and T. Vo-Dinh3.Light-Tissue Interactions, V.V. Tuchin 4.Theoretical Models and Algorithms in Optical Diffusion Tomography, S.J. Norton and T. Vo-DinhPHOTONIC DEVICES5.Laser Light in Biomedicine and the Life Sciences: From the Present to the Future, V.S. Letokhov6.Basic Instrumentation in Photonics, T. Vo-Dinh7.Optical Fibers and Waveguides for Medical Applications, I. Gannot and

  18. Biomedical signals and systems

    CERN Document Server

    Tranquillo, Joseph V

    2013-01-01

    Biomedical Signals and Systems is meant to accompany a one-semester undergraduate signals and systems course. It may also serve as a quick-start for graduate students or faculty interested in how signals and systems techniques can be applied to living systems. The biological nature of the examples allows for systems thinking to be applied to electrical, mechanical, fluid, chemical, thermal and even optical systems. Each chapter focuses on a topic from classic signals and systems theory: System block diagrams, mathematical models, transforms, stability, feedback, system response, control, time

  19. Statistics in biomedical research

    Directory of Open Access Journals (Sweden)

    González-Manteiga, Wenceslao

    2007-06-01

    Full Text Available The discipline of biostatistics is nowadays a fundamental scientific component of biomedical, public health and health services research. Traditional and emerging areas of application include clinical trials research, observational studies, physiology, imaging, and genomics. The present article reviews the current situation of biostatistics, considering the statistical methods traditionally used in biomedical research, as well as the ongoing development of new methods in response to the new problems arising in medicine. Clearly, the successful application of statistics in biomedical research requires appropriate training of biostatisticians. This training should aim to give due consideration to emerging new areas of statistics, while at the same time retaining full coverage of the fundamentals of statistical theory and methodology. In addition, it is important that students of biostatistics receive formal training in relevant biomedical disciplines, such as epidemiology, clinical trials, molecular biology, genetics, and neuroscience.La Bioestadística es hoy en día una componente científica fundamental de la investigación en Biomedicina, salud pública y servicios de salud. Las áreas tradicionales y emergentes de aplicación incluyen ensayos clínicos, estudios observacionales, fisología, imágenes, y genómica. Este artículo repasa la situación actual de la Bioestadística, considerando los métodos estadísticos usados tradicionalmente en investigación biomédica, así como los recientes desarrollos de nuevos métodos, para dar respuesta a los nuevos problemas que surgen en Medicina. Obviamente, la aplicación fructífera de la estadística en investigación biomédica exige una formación adecuada de los bioestadísticos, formación que debería tener en cuenta las áreas emergentes en estadística, cubriendo al mismo tiempo los fundamentos de la teoría estadística y su metodología. Es importante, además, que los estudiantes de

  20. Advances in biomedical engineering

    CERN Document Server

    Brown, J H U

    1973-01-01

    Advances in Biomedical Engineering, Volume 3, is a collection of papers that discusses circulatory system models, linguistics in computer usage, and clinical applications on patient monitoring. One paper describes the use of comparative models of overall circulatory mechanics that include models of the cardiac pump, of the vascular systems, and of the overall systems behavior. Another paper describes a model in processing medical language data that employs an explicit semantic structure, becoming the basis for the computer-based, artificial intelligence of the system. One paper cites studies b