WorldWideScience

Sample records for inner-galaxy alfa low-latitude

  1. Cold atomic gas in the inner Galaxy

    International Nuclear Information System (INIS)

    Garwood, R.W.; Dickey, J.M.

    1989-01-01

    A new set of 21 cm H I absorption spectra were obtained toward 21 compact continuum sources in the Galactic plane is presented. The 21 cm line velocity-averaged absorption coefficient as a function of Galactocentric distance is calculated. The result for distances within 2 kpc of the sun agrees with the local value found from absorption toward pulsars of 5-7 km/s/kpc. Overall, the absorption coefficient decreases to about half of its local value inside a Galactocentric radius of about 4 kpc. This decrease is shown to be primarily due to an increase in the mean line-of-sight distance between absorbing atomic clouds. Thus, the cool phase of the atomic gas is less abundant in the inner Galaxy than at the solar circle. The absorption spectra are similar in appearance to existing (C-12)O spectra. The spectral regions which show H I absorption also show CO emission. 43 references

  2. Featured Image: Extinction in Our Inner Galaxy

    Science.gov (United States)

    Kohler, Susanna

    2017-11-01

    In this map of the innermost galaxy, which spans only a few square degrees at the Milky Ways center, we can seethe locations of more than 31 million objects obtained from the VISTA Variables in the Va Lctea (VVV) survey. This near-infrared atlas traces stellar populations in the inner Milky Way that are dimmed and reddened by interstellar dust and gas a process known as extinction in a predictable way. Led by Javier Alonso-Garca (University of Antofagasta and the Millennium Institute of Astrophysics in Chile), a team of scientists has now used the VVV measurements of these stars to better understand the distribution of gas and dust that causes extinction in our inner galaxy particularly in the most central, highly reddened, and crowded areas of the Milky Way. For more information, check out the paper below.CitationJavier Alonso-Garca et al 2017 ApJL 849 L13. doi:10.3847/2041-8213/aa92c3

  3. TeV Diffuse Emission From the Inner Galaxy

    Directory of Open Access Journals (Sweden)

    Amid Nayerhoda

    2018-04-01

    Full Text Available The TeV diffuse emission from the Galactic plane is produced by multi TeV electrons and nuclei interacting with radiation fields and ambient gas, respectively. Measurements of the TeV diffuse emission help constrain CR origin and transport properties. We present a preliminary analysis of HAWC diffuse emission data from the inner Galaxy. The HAWC measurements will be used to constrain particle transport properties close to the Galaxy center correlating the HAWC maps with predictions of the DRAGON code.

  4. A new perspective on mapping the inner Galaxy

    Directory of Open Access Journals (Sweden)

    Majewski S.R.

    2012-02-01

    Full Text Available Due to the very strong interstellar extinction in the inner Galaxy, the stellar complexities of this region have only recently begun to be explored, with many infrared surveys now taking advantage of the reduced extinction at longer wavelengths to study the geometry, chemistry, and dynamics of the Milky Way’s innermost kiloparsecs. The new approach presented here applies the RJCE extinction correction method and the longitude-magnitude visualization technique to an extensive near+mid-infrared database (2MASS + GLIMPSE, and we assess the usefulness of this approach in exploring large-scale Galactic structure. By deriving physical parameters of the long bar and central bulge, we demonstrate this approach’s efficacy in using archived data to trace large-scale structures previously only mapped by time-intensive, dedicated surveys.

  5. GOT C+ Survey of Transition Clouds in the Inner Galaxy

    Science.gov (United States)

    Velusamy, Thangasamy; Langer, W. D.; Pineda, J. L.; Goldsmith, P. F.; Li, D.; Yorke, H. W.

    2010-05-01

    To understand star formation and the lifecycle of the interstellar gas we need detailed information about the transition of diffuse atomic to molecular clouds. The C+ line at 1.9 THz traces a so-far poorly studied stage in cloud evolution - the transitional clouds going from atomic HI to molecular H2 The transition cloud phase, which is difficult to observe in HI and CO alone, may be best characterized via CII emission or absorption. Here we present the first results on transition clouds along a few representative lines of sight in the inner Galaxy from longitude 325 degrees to 10 degrees, observed under the GOT C+ program, a HIFI Herschel Key Project to study the diffuse ISM. We can separate out the different ISM components along each line of sight by comparisons of the high spectral resolution ( 1 km/s) and high sensitivity (rms 0.1 K to 0.2 K) HIFI data on C+ with HI, 12CO, and 13CO spectra. These observations are being carried out with the Herschel Space Observatory. This research was conducted at the Jet Propulsion Laboratory, California Institute of Technology under contract with the National Aeronautics and Space Administration. JLP is supported under the NASA Postdoctoral Program at JPL, Caltech, administered by Oak Ridge Associated Universities through a contract with NASA.

  6. Galactic Observations of Terahertz C+ (GOT C+): Inner Galaxy Survey

    Science.gov (United States)

    Yorke, Harold; Langer, William; Velusamy, T.; Pineda, J. L.; Goldsmith, P. F.; Li, D.

    To understand the lifecycle of the interstellar gas and star formation we need detailed information about the diffuse atomic and diffuse molecular gas cloud properties. The ionized carbon [CII] 1.9 THz fine structure line is an important tracer of the atomic gas in the diffuse regions and the interface regions of atomic gas to molecular clouds. Furthermore, C+ is a major ISM coolant and among the Galaxy's strongest far-IR emission lines, and thus controls the thermal conditions throughout large parts of the Galaxy. Until now our knowledge of interstellar gas has been limited to the diffuse atomic phase traced by HI and to the dense molecular H2 phase traced by CO. However, we are missing an important phase of the ISM, called "dark gas" in which there is no or little, HI, and mostly molecular hydrogen but with insufficient shielding of UV to allow CO to form. C+ emission and absorption lines at 1.9 THz have the potential to trace such cloud transitions and evolution. Galactic Observations of the Terahertz C+ Line (GOT C+) is a Herschel Space Observatory Open Time Key Program to study the diffuse interstellar medium by sampling [CII] 1.9 THz line emission throughout the Galactic disk. We discuss the broader perspective of this survey and the first results of GOT C+ obtained during the Science Demonstration Phase (SDP) and Priority Science Phase (PSP) of HIFI, which focus on approximately 100 lines of sight in the inner galaxy. These observations are being carried out with the Herschel Space Observatory, which is an ESA cornerstone mission, with contributions from NASA. This research was conducted at the Jet Propulsion Laboratory, California Institute of Technology under contract with the National Aeronautics and Space Administration. JLP is a Caltech-JPL Postdoctoral Associate.

  7. Topside electron density at low latitudes

    International Nuclear Information System (INIS)

    Ezquer, R.G.; Cabrera, M.A.; Flores, R.F.; Mosert, M.

    2002-01-01

    The validity of IRI to predict the electron density at the topside electron density profile over the low latitude region is checked. The comparison with measurements obtained with the Taiyo satellite during low solar activity shows that, the disagreement between prediction and measurement is lower than 40% for 70% of considered cases. These IRI predictions are better than those obtained in a previous work at the southern peak of the equatorial anomaly for high solar activity. Additional studies for low solar activity, using ionosonde data as input parameters in the model, are needed in order to check if the observed deviations are due to the predicted peak characteristics or to the predicted shape of the topside profile. (author)

  8. The low-latitude Rapitan glaciation (Invited)

    Science.gov (United States)

    MacDonald, F. A.; Schmitz, M. D.; Crowley, J. L.; Roots, C.; Maloof, A. C.; Jones, D. S.; Strauss, J.

    2009-12-01

    The snowball Earth hypothesis1 was developed in response to strong palaeomagnetic evidence for low-latitude glaciation from “Marinoan” glacial deposits in the Elatina Formation of Australia. An earlier Cryogenian glaciation, commonly referred to as the “Sturtian” glaciation, has been inferred from the ubiquity of pre-Marinoan glacial deposits; however, the synchroneity and global extent of this event have been questioned due to the lack of precise U/Pb ages and robust paleomagnetic data. Herein we provide new age constraints on the Franklin LIP with revised U/Pb ID-TIMS dates on the the Mt. Harper volcanic complex in the Yukon Territory and the Coronation sills of Victoria Island. Furthermore we present a new age from a tuff interbedded with diamictite in the Upper Mt. Harper Group. A glaciogenic origin of the diamictites is provided by striated clasts and laminae-penetrating dropstones. These glacial deposits can be traced from Alaska westward through the Yukon Territory and into the Northwest Territories, and are correlative to the Rapitan Group. Throughout the Cordillera, the Rapitan Group and its correlatives commonly host iron formation, are the lower of two Cryogenian glacial horizons, and globally are thought to be equivalent to the Sturtian glaciation. The age of the tuff interbedded with the glacial deposits in the Mt. Harper Group is within 1 million years of the revised age on the Franklin LIP. Several paleomagnetic studies on dikes, sills, and basalts spanning >2000 km of NW Canada have agreed that the Franklin LIP erupted when NW Laurentia was in an equatorial position2,3. Consequently, the Sturtian glaciation on Laurentia can now be confidently inferred to have occurred at a very low palaeolatitude. Thus, there were at least two Cryogenian glaciations of global extent. 1 Kirschvink, J.L., in The Proterozoic Biosphere, edited by J. W. Schopf and C. Klein (Cambridge University Press, Cambridge, 1992), pp. 51. 2 Park, J.K., Paleomagnetic

  9. Low latitude aurorae on October 21, 1989, 2

    International Nuclear Information System (INIS)

    Kuwashima, Masayuki; Tsunomura, Satoru; Uwai, Tetsuya; Saito, Buniti; Takahasi, Tosiyasu; Kiyama, Yositaka.

    1990-01-01

    Appearance of low-latitude aurorae was seen in Hokkaido, a northern district in Japan, on October 21 and November 17, 1989, during severe magnetic storms. Some characteristics of the associated magnetic variations are shown and discussed in the present short report. The appearance of low-latitude aurora events was found during a time interval of a sharp H-component increase succeeding to the maximum development of the storm time ring current. The cause of the increase in the H-component seems to be associated with the bay disturbance because Pi2 magnetic pulsations were always associated with the low-latitude aurora event. The period of an aurora associated Pi2 event is shorter (40-60 seconds) than that of a usual Pi2 event (100 seconds). During the main phase of geomagnetic storm on October 21, optical and spectroscopic observations of low latitude aurora were made with an airglow-photometer, spectrograph and an all sky camera at Niigata (latitude 37.7degN, longitude 138.8degE and geomagnetic latitude 27.7degN). Spectra of low latitude aurorae observed in Niigata are given and discussed. A model for the main part of the auroral emission is also presented. (N.K.)

  10. Multiflash whistlers in ELF-band observed at low latitude

    Directory of Open Access Journals (Sweden)

    A. K. Singh

    2011-01-01

    Full Text Available Multiflash whistler-like event in the ELF-band, observed during March 1998 at low latitude station Jammu, is reported. The most prominent feature of these events is the multiflash nature along with the decrease in frequency within a very short span of time resembling similar to terrestrial whistlers. The events have a significantly smaller time duration (0.5–3.5 s than those reported earlier from high, mid and low latitudes and also display a diurnal maximum occurring around 09:30 h (IST. There have been similar reportings from other latitudes, but whistlers in the ELF-band with a multiflash nature along with a precursor emission have never been reported. Lightning seems to be the dominant source for the ELF whistlers reported here.

  11. High accurate time system of the Low Latitude Meridian Circle.

    Science.gov (United States)

    Yang, Jing; Wang, Feng; Li, Zhiming

    In order to obtain the high accurate time signal for the Low Latitude Meridian Circle (LLMC), a new GPS accurate time system is developed which include GPS, 1 MC frequency source and self-made clock system. The second signal of GPS is synchronously used in the clock system and information can be collected by a computer automatically. The difficulty of the cancellation of the time keeper can be overcomed by using this system.

  12. Projected beam irradiation at low latitudes using Meteonorm database

    DEFF Research Database (Denmark)

    Hatwaambo, Sylvester; Perers, Bengt; Karlsson, Björn

    2009-01-01

    by a collector provided the projection angle lies within the acceptance angle. The Meteonorm method of calculating solar radiation on any arbitrary oriented surface uses the globally simulated meteorological databases. Meteonorm has become a valuable too for estimating solar radiation where measured solar...... radiation data is missing or irregular. In this paper we present the projected beam solar radiation at low latitudes based on the standard Meteonorm calculations. The conclusion is that there is potential in using solar concentrators at these latitudes since the projected beam radiation is more during...

  13. Earth's magnetosphere formed by the low-latitude boundary layer

    CERN Document Server

    Heikkila, W J

    2011-01-01

    The author argues that, after five decades of debate about the interactive of solar wind with the magnetosphere, it is time to get back to basics. Starting with Newton's law, this book also examines Maxwell's equations and subsidiary equations such as continuity, constitutive relations and the Lorentz transformation; Helmholtz' theorem, and Poynting's theorem, among other methods for understanding this interaction. Includes chapters on prompt particle acceleration to high energies, plasma transfer event, and the low latitude boundary layer More than 200 figures illustrate the text Includes a color insert.

  14. Biomarkers of a Low-Latitude Neoproterozoic Glaciation

    Science.gov (United States)

    Olcott, A. N.; Sessions, A. L.; Corsetti, F. A.; Kaufman, A. J.

    2005-12-01

    Neoproterozoic low-latitude glaciations are often considered times of great biologic limitation because of the hypothesized presence of thick, global sea ice. Alternatively, climate models have suggested that tropical oceans could have remained ice-free, or covered by only thin sea ice, allowing life to continue unimpeded throughout the glaciations. The analysis of organic remains from synglacial sediments provides an approach to address the debate. Here we describe molecular, isotopic, and petrographic analyses of organic rich strata (up to 3.0 percent TOC) deposited in southeastern Brazil during Neoproterozoic low-latitude glaciation ca. 700 Ma. These strata contain extractable biomarkers, including 2-α-methyl hopanes, 2,3,6-trimethylarylisoprenoids, C29-C31 hopanes, and C27-C29 steranes. The preserved biomarkers reflect the presence of a complex and productive ecosystem comprised of both aerobic and anaerobic phototrophs, heterotrophs, and eukaryotes. The biomarker data indicate euxinia extending into the photic zone, providing evidence that the oceans were strongly stratified. Significantly, the occurrence of photosynthetic cyanobacteria and green sulfur bacteria at this time indicates that sea-ice cover at this location was thin to nonexistent, and is incompatible with models for snowball Earth that envision kilometers of ice thickness.

  15. Movie-maps of low-latitude magnetic storm disturbance

    Science.gov (United States)

    Love, Jeffrey J.; Gannon, Jennifer L.

    2010-06-01

    We present 29 movie-maps of low-latitude horizontal-intensity magnetic disturbance for the years 1999-2006: 28 recording magnetic storms and 1 magnetically quiescent period. The movie-maps are derived from magnetic vector time series data collected at up to 25 ground-based observatories. Using a technique similar to that used in the calculation of Dst, a quiet time baseline is subtracted from the time series from each observatory. The remaining disturbance time series are shown in a polar coordinate system that accommodates both Earth rotation and the universal time dependence of magnetospheric disturbance. Each magnetic storm recorded in the movie-maps is different. While some standard interpretations about the storm time equatorial ring current appear to apply to certain moments and certain phases of some storms, the movie-maps also show substantial variety in the local time distribution of low-latitude magnetic disturbance, especially during storm commencements and storm main phases. All movie-maps are available at the U.S. Geological Survey Geomagnetism Program Web site (http://geomag.usgs.gov).

  16. Space weather at Low Latitudes: Considerations to improve its forecasting

    Science.gov (United States)

    Chau, J. L.; Goncharenko, L.; Valladares, C. E.; Milla, M. A.

    2013-05-01

    In this work we present a summary of space weather events that are unique to low-latitude regions. Special emphasis will be devoted to events that occur during so-called quiet (magnetically) conditions. One of these events is the occurrence of nighttime F-region irregularities, also known Equatorial Spread F (ESF). When such irregularities occur navigation and communications systems get disrupted or perturbed. After more than 70 years of studies, many features of ESF irregularities (climatology, physical mechanisms, longitudinal dependence, time dependence, etc.) are well known, but so far they cannot be forecast on time scales of minutes to hours. We present a summary of some of these features and some of the efforts being conducted to contribute to their forecasting. In addition to ESF, we have recently identified a clear connection between lower atmospheric forcing and the low latitude variability, particularly during the so-called sudden stratospheric warming (SSW) events. During SSW events and magnetically quiet conditions, we have observed changes in total electron content (TEC) that are comparable to changes that occur during strong magnetically disturbed conditions. We present results from recent events as well as outline potential efforts to forecast the ionospheric effects during these events.

  17. Hook whistlers observed at low latitude ground station Varanasi

    International Nuclear Information System (INIS)

    Khosa, P.N.; Lalmani; Ahmed, M.M.; Singh, B.D.

    1983-01-01

    Employing the Haselgrove ray tracing equations and a diffusive equilibrium model of the ionosphere, the propagation characteristics of hook whistlers recorded at low-latitude ground station Varanasi (geomag. lat., 16 0 6'N) are discussed. It is shown that the two traces of the hook whistlers are caused by the VLF waves radiated from the return stroke of a lightning discharge which after penetrating the ionosphere at two different entry points, propagated to the opposite hemisphere in the whistler mode and were received at 16 geomagnetic latitude. Further the crossing of ray paths for the same frequency leads to the explanation of the hook whistler. The lower and higher cut-off frequencies are explained in terms of their deviating away from the bunch of the recorded whistler waves and crossing of ray paths for the same frequency. (Auth.)

  18. A low-latitude southern atlas of galactic hydrogen

    Energy Technology Data Exchange (ETDEWEB)

    Poeppel, W G.L. [Instituto Argentino de Radioastronomia, Villa Elisa, Buenos Aires, Argentina; Olano, C A [Rio Grande do Sul, Universidade Federal, Porto Alegre, Brazil

    1979-01-01

    An atlas of 21 cm line profiles is described, which was made using a 30 m radio telescope with angular resolution of 0.5 deg, to study the properties of the low latitude H I gas excluding the complexity of the galactic plane. The results of the atlas itself are presented in two sets of diagrams: average profiles for each point, and contour maps. Analyses of the data have centered on an anomalous velocity cloud near galactic longitude (1) equals 349 deg, and latitude (b) equals plus 3 deg, strong kinematic asymmetries of the interstellar gas in the region of 1 between 348 and 12 deg and b between plus 3 and plus 17 deg, with positive radial velocities predominant, caused by a very intense source seemingly identical to Lindblad's (1967) feature A, and a comparative study of optical and radioastronomical data of the section of Gould's belt from 1 equals 300 to 12 deg.

  19. Low-latitude particle precipitation and associated local magnetic disturbances

    International Nuclear Information System (INIS)

    Rassoul, H.K.; Rohrbaugh, R.P.; Tinsley, B.A.

    1992-01-01

    The time variations of optical emissions during low-latitude auroral events have been shown to correlate well with those of magnetograms in the region where the aurorae are observed. Two events not previously reported are analyzed and are shown to confirm the nature of the correlations found for two earlier events. The maximum optical emissions at mid-latitudes occur in concert with the maximum positive (northward) excursions in the H trace and with rapid fluctuations in the D trace of nearby magnetograms. The fluctuation in ΔD is usually from the east (positive) to the west (negative) in the vicinity of the ΔH perturbation. The positive excursions in H at low-latitude observatories at the time of the maximum optical emissions are associated with negative H excursions at high latitude observatories in the same longitude sector. The source of the particles has been inferred to be the ring current, with precipitation occurring when the |Dst| index is large at the time of the large short term excursions in the local magnetic field. This result is consistent with the funding of Voss and Smith (1979), derived from a series of rocket measurements of precipitating heavy particles, that the flux correlates better with the product of |Dst| and the exponential of K p than with either alone. In the present case it is shown that the product of |Dst| and the amplitude of the short term excursions in the horizontal component in local magnetograms has better time resolution and better correlation with the observed emission rates than the index using K p

  20. Analysis of the atmospheric upward radiation in low latitude area

    Science.gov (United States)

    Li, Haiying; Wu, Zhensen; Lin, Leke; Lu, Changsheng

    2016-10-01

    Remote sensing using THz wave has irreplaceable advantage comparing to the microwave and the infrared waves, and study on the THz remote sensing become more and more popular in recent years. The major applications of the remote sensing in THz wavelengths are the retrieval of the atmospheric parameters and the microphysical information of the ice cloud. The remote sensing of the atmosphere is based on the radiation of THz wave along the earth-space path of which the most significant part is the upward radiation of the atmosphere. The upward radiation of the atmosphere in sunny day in the low latitude area is computed and analyzed in this paper. The absorption of THz wave by the atmosphere is calculated using the formulations illustrated in the Recommendation ITU-R P.676 to save machine hour, the frequency range is then restricted below 1THz. The frequencies used for the retrieval of atmospheric parameters such as temperature and water content are usually a few hundred GHz, at the lower end of THz wavelengths, so this frequency range is sufficient. The radiation contribution of every atmospheric layer for typical frequencies such as absorption window frequencies and peak frequencies are analyzed. Results show that at frequencies which absorption is severe, information about lower atmosphere cannot reach the receiver onboard a satellite or other high platforms due to the strong absorption along the path.

  1. Lidar measurements of mesospheric temperature inversion at a low latitude

    Energy Technology Data Exchange (ETDEWEB)

    Siva Kumar, V.; Bhavani Kumar, Y.; Raghunath, K.; Rao, P.B. [National MST Radar Facility, Tirupati (India); Krishnaiah, M. [Sri Venkateswara Univ., Tirupati (India). Dept. of Physics; Mizutani, K.; Aoki, T.; Yasui, M.; Itabe, T. [Communication Research Lab., Tokyo (Japan)

    2001-08-01

    The Rayleigh lidar data collected on 119 nights from March 1998 to February 2000 were used to study the statistical characteristics of the low latitude mesospheric temperature inversion observed over Gadanki (13.5 N, 79.2 E), India. The occurrence frequency of the inversion showed semiannual variation with maxima in the equinoxes and minima in the summer and winter, which was quite different from that reported for the mid-latitudes. The peak of the inversion layer was found to be confined to the height range of 73 to 79 km with the maximum occurrence centered around 76 km, with a weak seasonal dependence that fits well to an annual cycle with a maximum in June and a minimum in December. The magnitude of the temperature deviation associated with the inversion was found to be as high as 32 K, with the most probable value occurring at about 20 K. Its seasonal dependence seems to follow an annual cycle with a maximum in April and a minimum in October. The observed characteristics of the inversion layer are compared with that of the mid-latitudes and discussed in light of the current understanding of the source mechanisms. (orig.)

  2. Lidar measurements of mesospheric temperature inversion at a low latitude

    Directory of Open Access Journals (Sweden)

    V. Siva Kumar

    2001-08-01

    Full Text Available The Rayleigh lidar data collected on 119 nights from March 1998 to February 2000 were used to study the statistical characteristics of the low latitude mesospheric temperature inversion observed over Gadanki (13.5° N, 79.2° E, India. The occurrence frequency of the inversion showed semiannual variation with maxima in the equinoxes and minima in the summer and winter, which was quite different from that reported for the mid-latitudes. The peak of the inversion layer was found to be confined to the height range of 73 to 79 km with the maximum occurrence centered around 76 km, with a weak seasonal dependence that fits well to an annual cycle with a maximum in June and a minimum in December. The magnitude of the temperature deviation associated with the inversion was found to be as high as 32 K, with the most probable value occurring at about 20 K. Its seasonal dependence seems to follow an annual cycle with a maximum in April and a minimum in October. The observed characteristics of the inversion layer are compared with that of the mid-latitudes and discussed in light of the current understanding of the source mechanisms.Key words. Atmospheric composition and structure (pressure, density and temperature. Meterology and atmospheric dynamics (climatology

  3. Early onset of significant local warming in low latitude countries

    International Nuclear Information System (INIS)

    Mahlstein, I; Knutti, R; Solomon, S; Portmann, R W

    2011-01-01

    The Earth is warming on average, and most of the global warming of the past half-century can very likely be attributed to human influence. But the climate in particular locations is much more variable, raising the question of where and when local changes could become perceptible enough to be obvious to people in the form of local warming that exceeds interannual variability; indeed only a few studies have addressed the significance of local signals relative to variability. It is well known that the largest total warming is expected to occur in high latitudes, but high latitudes are also subject to the largest variability, delaying the emergence of significant changes there. Here we show that due to the small temperature variability from one year to another, the earliest emergence of significant warming occurs in the summer season in low latitude countries (∼25 deg. S-25 deg. N). We also show that a local warming signal that exceeds past variability is emerging at present, or will likely emerge in the next two decades, in many tropical countries. Further, for most countries worldwide, a mean global warming of 1 deg. C is sufficient for a significant temperature change, which is less than the total warming projected for any economically plausible emission scenario. The most strongly affected countries emit small amounts of CO 2 per capita and have therefore contributed little to the changes in climate that they are beginning to experience.

  4. Lidar measurements of mesospheric temperature inversion at a low latitude

    Directory of Open Access Journals (Sweden)

    V. Siva Kumar

    Full Text Available The Rayleigh lidar data collected on 119 nights from March 1998 to February 2000 were used to study the statistical characteristics of the low latitude mesospheric temperature inversion observed over Gadanki (13.5° N, 79.2° E, India. The occurrence frequency of the inversion showed semiannual variation with maxima in the equinoxes and minima in the summer and winter, which was quite different from that reported for the mid-latitudes. The peak of the inversion layer was found to be confined to the height range of 73 to 79 km with the maximum occurrence centered around 76 km, with a weak seasonal dependence that fits well to an annual cycle with a maximum in June and a minimum in December. The magnitude of the temperature deviation associated with the inversion was found to be as high as 32 K, with the most probable value occurring at about 20 K. Its seasonal dependence seems to follow an annual cycle with a maximum in April and a minimum in October. The observed characteristics of the inversion layer are compared with that of the mid-latitudes and discussed in light of the current understanding of the source mechanisms.

    Key words. Atmospheric composition and structure (pressure, density and temperature. Meterology and atmospheric dynamics (climatology

  5. Galactic Observations of Terahertz C+ (GOT C+): First Results: Inner Galaxy Survey

    Science.gov (United States)

    Langer, William; Velusamy, T.; Pineda, J. L.; Goldsmith, P. F.; Li, D.; Yorke, H. W.

    2010-05-01

    To understand the lifecycle of the interstellar gas and star formation we need detailed information about the diffuse atomic and diffuse molecular gas cloud properties. The ionized carbon [CII] 1.9 THz fine structure line is an important tracer of the atomic gas in the diffuse regions and the interface regions of atomic gas to molecular clouds. Furthermore, C+ is a major ISM coolant and among the Galaxy's strongest far-IR emission lines, and thus controls the thermal conditions throughout large parts of the Galaxy. Until now our knowledge of interstellar gas has been limited to the diffuse atomic phase traced by HI and to the dense molecular H2 phase traced by CO. However, we are missing an important phase of the ISM called "dark gas” in which there is no or little, HI, and mostly molecular hydrogen but with insufficient shielding of UV to allow CO to form. C+ emission and absorption lines at 1.9 THz have the potential to trace this gas. Galactic Observations of the Terahertz C+ Line (GOT C+) is a Herschel Space Observatory Open Time Key Program to study the diffuse interstellar medium by sampling [CII] 1.9 THz line emission throughout the Galactic disk. We discuss the broader perspective of this survey and the first results of GOT C+ obtained during the Science Demonstration Phase (SDP) and Priority Science Phase (PSP) of HIFI, which focus on approximately 100 lines of sight in the inner galaxy. This research was conducted at the Jet Propulsion Laboratory, California Institute of Technology under contract with the National Aeronautics and Space Administration.

  6. The Abnormal Quiet Days in SQ(H) in Mid and Low Latitudes Regions

    African Journals Online (AJOL)

    From the analysis and study of abnormal quiet days (AQDs) at mid and low latitudes locations, it was found that there is difference between the characteristics of phase variability Sq (H) of the low latitude locations. This suggests that the origin and cause of AQDs are of different sources in the two latitude regions. The AQDs ...

  7. Low mass X-ray binaries in the Inner Galaxy: implications for millisecond pulsars and the GeV excess

    Energy Technology Data Exchange (ETDEWEB)

    Haggard, Daryl; Heinke, Craig; Hooper, Dan; Linden, Tim

    2017-05-01

    If millisecond pulsars (MSPs) are responsible for the excess gamma-ray emission observed from the region surrounding the Galactic Center, the same region should also contain a large population of low-mass X-ray binaries (LMXBs). In this study, we compile and utilize a sizable catalog of LMXBs observed in the the Milky Way's globular cluster system and in the Inner Galaxy, as well as the gamma-ray emission observed from globular clusters, to estimate the flux of gamma rays predicted from MSPs in the Inner Galaxy. From this comparison, we conclude that only up to $\\sim$4-23% of the observed gamma-ray excess is likely to originate from MSPs. This result is consistent with, and more robust than, previous estimates which utilized smaller samples of both globular clusters and LMXBs. If MSPs had been responsible for the entirety of the observed excess, INTEGRAL should have detected $\\sim$$10^3$ LMXBs from within a $10^{\\circ}$ radius around the Galactic Center, whereas only 42 LMXBs (and 46 additional LMXB candidates) have been observed.

  8. Drotrecogin alfa Eli Lilly

    NARCIS (Netherlands)

    de Jonge, E.

    2002-01-01

    Drotrecogin alfa (Xigris, recombinant activated protein C) is an anticoagulant developed and launched by Eli Lilly & Co for the treatment of sepsis [333781], [339372], [430133], [436271]. The FDA and the EMEA accepted the brand name Xigris for drotrecogin alfa in June 2001. This trade name had been

  9. ALFA Detector Control System

    CERN Document Server

    Oleiro Seabra, Luis Filipe; The ATLAS collaboration

    2015-01-01

    ALFA (Absolute Luminosity For ATLAS) is one of the sub-detectors of ATLAS (A Toroidal LHC Apparatus). The ALFA system is composed by four stations installed in the LHC tunnel 240 m away from the ATLAS interaction point. Each station has a vacuum and ventilation system, movement control and all the required electronics for signal processing. The Detector Control System (DCS) provides control and monitoring of several components and ensures the safe operation of the detector contributing to good Data Quality. This paper describes the ALFA DCS system including a detector overview, operation aspects and hardware control through a SCADA system, WinCC OA.

  10. ALFA Detector Control System

    CERN Document Server

    Oleiro Seabra, Luis Filipe; The ATLAS collaboration

    2015-01-01

    ALFA (Absolute Luminosity For ATLAS) is one of the sub-detectors of ATLAS/LHC. The ALFA system is composed by two stations installed in the LHC tunnel 240 m away from each side of the ATLAS interaction point. Each station has a vacuum and ventilation system, movement control and all the required electronic for signal processing. The Detector Control System (DCS) provides control and monitoring of several components and ensures the safe operation of the detector contributing to good Data Quality. This paper describes the ALFA DCS system including a detector overview, operation aspects and hardware control through a SCADA system, WinCC OA.

  11. GOT C+ Survey of [CII] 158 μm Emission: Atomic to Molecular Cloud Transitions in the Inner Galaxy

    Science.gov (United States)

    Velusamy, T.; Langer, W. D.; Willacy, K.; Pineda, J. L.; Goldsmith, P. F.

    2013-03-01

    We present the results of the distribution of CO-dark H2 gas in a sample of 2223 interstellar clouds in the inner Galaxy (l=-90° to +57°) detected in the velocity resolved [CII] spectra observed in the GOT C+ survey using the Herschel HIFI. We analyze the [CII] intensities along with the ancillary HI, 12CO and 13CO data for each cloud to determine their evolutionary state and to derive the H2 column densities in the C+ and C+/CO transition layers in the cloud. We discuss the overall Galactic distribution of the [CII] clouds and their properties as a function Galactic radius. GOT C+ results on the global distribution of [CII] clouds and CO-dark H2 gas traces the FUV intensity and star formation rate in the Galactic disk.

  12. Westward tilt of low-latitude plasma blobs as observed by the Swarm constellation

    DEFF Research Database (Denmark)

    Park, Jaeheung; Luehr, Hermann; Michaelis, Ingo

    2015-01-01

    In this study we investigate the three-dimensional structure of low-latitude plasma blobs using multi-instrument and multisatellite observations of the Swarm constellation. During the early commissioning phase the Swarm satellites were flying at the same altitude with zonal separation of about 0...

  13. Signatures of the low-latitude Pi 2 pulsations in Egypt

    Directory of Open Access Journals (Sweden)

    Essam Ghamry

    2012-06-01

    The result shows that the Pi 2 observed in the main phase of the geomagnetic storm have larger frequency than those observed in the recovery phase. These results excluded the field line resonance and the plasmapause surface as a possible generation mechanism, and suggest the cavity resonance as a possible generation mechanism of the Pi 2 pulsations at low latitude stations in Egypt.

  14. Effects of High-Latitude Forcing Uncertainty on the Low-Latitude and Midlatitude Ionosphere

    Science.gov (United States)

    Pedatella, N. M.; Lu, G.; Richmond, A. D.

    2018-01-01

    Ensemble simulations are performed using the Thermosphere-Ionosphere-Electrodynamics General Circulation Model (TIE-GCM) in order to understand the role of high-latitude forcing uncertainty on the low-latitude and midlatitude ionosphere response to the April 2010 geomagnetic storm. The ensemble is generated by perturbing either the high-latitude electric potential or auroral energy flux in the assimilative mapping for ionosphere electrodynamics (AMIE). Simulations with perturbed high-latitude electric potential result in substantial intraensemble variability in the low-latitude and midlatitude ionosphere response to the geomagnetic storm, and the ensemble standard deviation for the change in NmF2 reaches 50-100% of the mean change. Such large intraensemble variability is not seen when perturbing the auroral energy flux. In this case, the effects of the forcing uncertainty are primarily confined to high latitudes. We therefore conclude that the specification of high-latitude electric fields is an important source of uncertainty when modeling the low-latitude and midlatitude ionosphere response to a geomagnetic storm. A multiple linear regression analysis of the results indicates that uncertainty in the storm time changes in the equatorial electric fields, neutral winds, and neutral composition can all contribute to the uncertainty in the ionosphere electron density. The results of the present study provide insight into the possible uncertainty in simulations of the low-latitude and midlatitude ionosphere response to geomagnetic storms due to imperfect knowledge of the high-latitude forcing.

  15. Effect of Magnetic Activity on Ionospheric Time Delay at Low Latitude

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... The purpose of this work is to investigate the effect of magnetic activity on ionospheric time delay at low latitude Station Bhopal (geom. lat. 23.2°N, geom. long. 77.6°E) using ... Space Science Laboratory, Department of Physics, Barkatullah University, Bhopal 462 026, India. National Institute of Technical, ...

  16. Characteristics of Low-latitude Coronal Holes near the Maximum of Solar Cycle 24

    DEFF Research Database (Denmark)

    Hofmeister, Stefan J.; Veronig, Astrid; Reiss, Martin A.

    2017-01-01

    We investigate the statistics of 288 low-latitude coronal holes extracted from SDO/AIA-193 filtergrams over the time range of 2011 January 01–2013 December 31. We analyze the distribution of characteristic coronal hole properties, such as the areas, mean AIA-193 intensities, and mean magnetic fie...

  17. Drotrecogin alfa Eli Lilly.

    Science.gov (United States)

    de Jonge, E

    2002-04-01

    Drotrecogin alfa (Xigris, recombinant activated protein C) is an anticoagulant developed and launched by Eli Lilly & Co for the treatment of sepsis [333781], [339372], [430133], [436271]. The FDA and the EMEA accepted the brand name Xigris for drotrecogin alfa in June 2001. This trade name had been proposed by Lilly in place of the previous brand name, Zovant, which was deemed unacceptable by the EMEA due to concerns that the name could be confused with hospital-based drugs [412512]. Filings for sepsis were made in the US, EU and Australia in February 2001 [398514], [447870] and in March 2001, the US FDA assigned drotrecogin alfa Priority Review status [403435]. The FDA extended the action date from July 27 to October 27, 2001 for completion of its review of the biologics license application (BLA) for drotrecogin alfa to assess further supplementary data submitted by Lilly [412512]. At the October 16, 2001 meeting (postponed from September 12), the FDA Advisory Committee on Anti-Infective Drugs split 10 to 10 over whether to recommend approval [425873], [425940]. In late October 2001, Lilly received an approvable letter from the FDA for the treatment of severe sepsis. Approval was contingent upon successful negotiation of labeling, agreement on post-approval clinical trials, and successful completion of manufacturing inspections [427301]. In November 2001, the FDA approved drotrecogin alfa for the reduction of mortality in adult patients with severe sepsis who have a high risk of death [430133]; the product was launched onto the US market days later [436271]. Following the FDA committee's split decision in October 2001, Credit Suisse First Boston, which expected mid-2002 approval but with restrictive labeling, revised its predictions from $1.265 billion in 2004 sharply downwards to $543 million [425929].

  18. Effect of geomagnetic storms on the daytime low-latitude thermospheric wave dynamics

    Science.gov (United States)

    Karan, Deepak K.; Pallamraju, Duggirala

    2018-05-01

    The equatorial- and low-latitude thermospheric dynamics is affected by both equatorial electrodynamics and neutral wave dynamics, the relative variation of which is dependent on the prevalent background conditions, which in turn has a seasonal dependence. Depending on the ambient thermospheric conditions, varying effects of the geomagnetic disturbances on the equatorial- and low-latitude thermosphere are observed. To investigate the effect of these disturbances on the equatorial- and low-latitude neutral wave dynamics, daytime airglow emission intensities at OI 557.7 nm, OI 630.0 nm, and OI 777.4 nm are used. These emissions from over a large field-of-view (FOV∼1000) have been obtained using a high resolution slit spectrograph, MISE (Multiwavelength Imaging Spectrograph using Echelle grating), from a low-latitude location, Hyderabad (17.50N, 78.40E; 8.90N MLAT), in India. Variations of the dayglow emission intensities are investigated during three geomagnetic disturbance events that occurred in different seasons. It is seen that the neutral dayglow emission intensities at all the three wavelengths showed different type of variations with the disturbance storm time (Dst) index in different seasons. Even though the dayglow emission intensities over low-latitude regions are sensitive to the variation in the equatorial electric fields, during periods of geomagnetic disturbances, especially in solstices, these are dependent on thermospheric O/N2 values. This shows the dominance of neutral dynamics over electrodynamics in the low-latitude upper atmosphere during geomagnetic disturbances. Further, spectral analyses have been carried out to obtain the zonal scale sizes in the gravity wave regime and their diurnal distributions are compared for geomagnetic quiet and disturbed days. Broadly, the zonal scales seem to be breaking into various scale sizes on days of geomagnetic disturbances when compared to those on quiet days. This contrast in the diurnal distribution of the

  19. Star formation in the inner galaxy: a far-infrared and radio study of two H2 regions

    International Nuclear Information System (INIS)

    Lester, D.F.; Dinerstein, H.L.; Werner, M.W.; Harvey, P.M.; Evans, N.J.II; Brown, R.L.

    1985-12-01

    Far-infrared and radio continuum maps have been made of the central 6' of the inner-galaxy H II regions G30.8-0.0 (in the W43 complex) and G25.4-02., along with radio and molecular line measurements at selected positions. An effort is made to understand far infrared wavelingths allow the dust temperature structures and total far infrared fluxes to be determined. Comparison of the radio and infrared maps shows a close relationship between the ionized gas and the infrared-emitting material. There is evidence that parts of G30.8 are substantially affected by extinction, even at far-infrared wavelengths. For G25.4-0.2, the radio recombination line and CO line data permit resolution of the distance ambiguity for this source. The confusion in distance determination is found to result from an extraordinary near-superposition of two bright H II regions. Using revised distances of 4.3 kpc for G26.4SE and 12 kpc for G25.4NW, that the latter, which is apparently the fainter of the two sources, is actually the more luminous. Though it is not seen on the Palomar Sky Survey, G25.4SE is easily visible in the 9532A line of S III and is mapped in this line. The ratio of total luminosity to ionizing luminosity is very similar to that of H II regions in the solar circle. Assuming a coeval population of ionizing stars, a normal initial mass function is indicated

  20. Star formation in the inner galaxy: a far-infrared and radio study of two H2 regions

    International Nuclear Information System (INIS)

    Lester, D.F.; Dinerstein, H.L.; Werner, M.W.; Harvey, P.M.; Evans, N.J.; Brown, R.L.

    1985-09-01

    Far-infrared and radio continuum maps have been made of the central 6' of the inner-galaxy HII regions G30.8-0.0 (in the W43 complex) and G25.4-0.2, along with radio and molecular line measurements at selected positions. The purpose of this study is an effort to understand star formation in the molecular ring at 5 kpc in galactic radius. Measurements at several far infrared wavelengths allow the dust temperature structures and total far infrared fluxes to be determined. Comparison of the radio and infrared maps shows a close relationship between the ionized gas and the infrared-emitting material. There is evidence that parts of G30.8 are substantially affected by extinction, even at far-infrared wavelengths. Using radio recombination line and CO line data for G25.4-0.2, the distance ambiguity for this source is resolved. The large distance previously ascribed to the entire complex is found to apply to only one of the two main components. The confusion in distance determination is found to result from an extraordinary near-superposition of two bright HII regions. Using the revised distances of 4.3 kpc for G25.4SE and 12 kpc for G25.4NW, it is found that the latter, which is apparently the fainter of the two sources, is actually the more luminous. The ratio of total luminosity to ionizing luminosity is very similar to that of HII regions in the solar circle. Assuming a coeval population of ionizing stars, a normal initial mass function is indicated

  1. Rare observation of daytime whistlers at very low latitude (L = 1.08)

    Science.gov (United States)

    Gokani, Sneha A.; Singh, Rajesh; Tulasi Ram, S.; Venkatesham, K.; Veenadhari, B.; Kumar, Sandeep; Selvakumaran, R.

    2018-04-01

    The source region and propagation mechanism of low latitude whistlers (Geomag. lat. point. But the plausible conditions of ionospheric medium through which they travel are still uncertain. In addition to that, the whistlers in daytime are never observed at geomagnetic latitudes less than 20°. Here, for the first time, we present a rare observations of whistlers during sunlit hours from a very low-latitude station Allahabad (Geomag. Lat: 16.79°N, L = 1.08) in India on 04 February 2011. More than 90 whistlers are recorded during 1200-1300 UT during which the whole propagation path from lightning source region to whistler observation site is under sunlit. The favorable factors that facilitated the whistlers prior to the sunset are investigated in terms of source lightning characteristics, geomagnetic and background ionospheric medium conditions. The whistler activity period was found to be geomagnetically quiet. However, a significant suppression in ionospheric total electron content (TEC) compared to its quiet day average is found. This shows that background ionospheric conditions may play a key role in low latitude whistler propagation. This study reveals that whistlers can occur under sunlit hours at latitudes as low as L = 1.08 when the source lightning and ionospheric medium characteristics are optimally favorable.

  2. Low-latitude active longitudes on the Sun and in interplanetary space

    International Nuclear Information System (INIS)

    Bumba, V.; Hejna, L.

    1991-01-01

    Following a short review of the history of the development of the active longitude concept, several graphs are given of the longitudinal distribution of various low-latitude phenomena of solar activity published by various authors. The inclinations of the active longitudes found were calculated. A summary picture of all these inclinations demonstrates the concentration of such active longitudes into two main directions. Two values of synodic rotation: 26.77 days and 27.16 days, correspond to these two types of low-latitude active longitudes, rotating faster than Carrington's rotation. The summary graph of all active longitudes belonging to these two types shows that active longitudes of different activity phenomena and from different authors overlap to a relatively high degree and that they run at least through three eleven-year cycles. The first of these active longitudes moves around the whole Sun in about 45-55 rotations and the second one in about 200 Carrington's rotations. It is believed that both these low-latitude active longitudes have their reflections in the two main inclinations of the interplanetary magnetic field sector boundaries demonstrated by Svalgaard and Wilcox (1975), their synodic rotations being 26.84 days and 27.14 days. (author). 9 figs., 25 refs

  3. LION: A dynamic computer model for the low-latitude ionosphere

    Directory of Open Access Journals (Sweden)

    J. A. Bittencourt

    2007-11-01

    Full Text Available A realistic fully time-dependent computer model, denominated LION (Low-latitude Ionospheric model, that simulates the dynamic behavior of the low-latitude ionosphere is presented. The time evolution and spatial distribution of the ionospheric particle densities and velocities are computed by numerically solving the time-dependent, coupled, nonlinear system of continuity and momentum equations for the ions O+, O2+, NO+, N2+ and N+, taking into account photoionization of the atmospheric species by the solar extreme ultraviolet radiation, chemical and ionic production and loss reactions, and plasma transport processes, including the ionospheric effects of thermospheric neutral winds, plasma diffusion and electromagnetic E×B plasma drifts. The Earth's magnetic field is represented by a tilted centered magnetic dipole. This set of coupled nonlinear equations is solved along a given magnetic field line in a Lagrangian frame of reference moving vertically, in the magnetic meridian plane, with the electromagnetic E×B plasma drift velocity. The spatial and time distribution of the thermospheric neutral wind velocities and the pattern of the electromagnetic drifts are taken as known quantities, given through specified analytical or empirical models. The model simulation results are presented in the form of computer-generated color maps and reproduce the typical ionization distribution and time evolution normally observed in the low-latitude ionosphere, including details of the equatorial Appleton anomaly dynamics. The specific effects on the ionosphere due to changes in the thermospheric neutral winds and the electromagnetic plasma drifts can be investigated using different wind and drift models, including the important longitudinal effects associated with magnetic declination dependence and latitudinal separation between geographic and

  4. LION: A dynamic computer model for the low-latitude ionosphere

    Directory of Open Access Journals (Sweden)

    J. A. Bittencourt

    2007-11-01

    Full Text Available A realistic fully time-dependent computer model, denominated LION (Low-latitude Ionospheric model, that simulates the dynamic behavior of the low-latitude ionosphere is presented. The time evolution and spatial distribution of the ionospheric particle densities and velocities are computed by numerically solving the time-dependent, coupled, nonlinear system of continuity and momentum equations for the ions O+, O2+, NO+, N2+ and N+, taking into account photoionization of the atmospheric species by the solar extreme ultraviolet radiation, chemical and ionic production and loss reactions, and plasma transport processes, including the ionospheric effects of thermospheric neutral winds, plasma diffusion and electromagnetic E×B plasma drifts. The Earth's magnetic field is represented by a tilted centered magnetic dipole. This set of coupled nonlinear equations is solved along a given magnetic field line in a Lagrangian frame of reference moving vertically, in the magnetic meridian plane, with the electromagnetic E×B plasma drift velocity. The spatial and time distribution of the thermospheric neutral wind velocities and the pattern of the electromagnetic drifts are taken as known quantities, given through specified analytical or empirical models. The model simulation results are presented in the form of computer-generated color maps and reproduce the typical ionization distribution and time evolution normally observed in the low-latitude ionosphere, including details of the equatorial Appleton anomaly dynamics. The specific effects on the ionosphere due to changes in the thermospheric neutral winds and the electromagnetic plasma drifts can be investigated using different wind and drift models, including the important longitudinal effects associated with magnetic declination dependence and latitudinal separation between geographic and geomagnetic equators. The model runs in a normal personal computer (PC and generates color maps illustrating the

  5. Methods in ALFA Alignment

    CERN Document Server

    Melendez, Jordan

    2014-01-01

    This note presents two model-independent methods for use in the alignment of the ALFA forward detectors. Using a Monte Carlo simulated LHC run at \\beta = 90m and \\sqrt{s} = 7 TeV, the Kinematic Peak alignment method is utilized to reconstruct the Mandelstam momentum transfer variable t for single-diractive protons. The Hot Spot method uses fluctuations in the hitmap density to pinpoint particular regions in the detector that could signal a misalignment. Another method uses an error function fit to find the detector edge. With this information, the vertical alignment can be determined.

  6. A high-latitude, low-latitude boundary layer model of the convection current system

    International Nuclear Information System (INIS)

    Siscoe, G.L.; Lotko, W.; Sonnerup, B.U.O.

    1991-01-01

    Observations suggest that both the high- and low-latitude boundary layers contribute to magnetospheric convection, and that their contributions are linked. In the interpretation pursued here, the high-latitude boundary layer (HBL) generates the voltage while the low-latitude boundary layer (LBL) generates the current for the part of the convection electric circuit that closes through the ionosphere. This paper gives a model that joins the high- and low-latitude boundary layers consistently with the ionospheric Ohm's law. It describes an electric circuit linking both boundary layers, the region 1 Birkeland currents, and the ionospheric Pedersen closure currents. The model works by using the convection electric field that the ionosphere receives from the HBL to determine two boundary conditions to the equations that govern viscous LBL-ionosphere coupling. The result provides the needed self-consistent coupling between the two boundary layers and fully specifies the solution for the viscous LBL-ionosphere coupling equations. The solution shows that in providing the current required by the ionospheric Ohm's law, the LBL needs only a tenth of the voltage that spans the HBL. The solution also gives the latitude profiles of the ionospheric electric field, parallel currents, and parallel potential. It predicts that the plasma in the inner part of the LBL moves sunward instead of antisunward and that, as the transpolar potential decreases below about 40 kV, reverse polarity (region 0) currents appear at the poleward border of the region 1 currents. A possible problem with the model is its prediction of a thin boundary layer (∼1000 km), whereas thicknesses inferred from satellite data tend to be greater

  7. The climatology of low-latitude ionospheric densities and zonal drifts from IMAGE-FUV.

    Science.gov (United States)

    Immel, T. J.; Sagawa, E.; Frey, H. U.; Mende, S. B.; Patel, J.

    2004-12-01

    The IMAGE satellite was the first dedicated to magnetospheric imaging, but has also provided numerous images of the nightside ionosphere with its Far-Ultraviolet (FUV) spectrographic imager. Nightside emissions of O I at 135.6-nm originating away from the aurora are due to recombination of ionospheric O+, and vary in intensity with (O+)2. IMAGE-FUV, operating in a highly elliptical orbit with apogee at middle latitudes and >7 Re altitude, measures this emission globally with 100-km resolution. During each 14.5 hour orbit, IMAGE-FUV is able to monitor nightside ionospheric densities for up to 6-7 hours. Hundreds of low-latitude ionospheric bubbles, their development and drift speed, and a variety of other dynamical variations in brightness and morphology of the equatorial anomalies have been observed during this mission. Furthermore, the average global distribution of low-latitude ionospheric plasma densities can be determined in 3 days. Imaging data collected from February through June of 2002 are used to compile a dataset containing a variety of parameters (e.g., latitude and brightness of peak plasma density, zonal bubble drift speed) which can be drawn from for climatological studies. Recent results indicate that the average ground speed of low-latitude zonal plasma drifts vary with longitude by up to 50%, and that a periodic variation in ionospheric densities with longitude suggests the influence of a lower-thermospheric non-migrating tide with wave number = 4 on ionospheric densities. An excellent correlation between zonal drift speed and the magnetic storm index Dst is also found.

  8. Some studies of zonal and meridional wind characteristics at low latitude Indian stations

    Science.gov (United States)

    Nagpal, O. P.; Kumar, S.

    1985-12-01

    At the beginning of the Indian Middle Atmosphere Programme (IMAP), it was decided that the preparation of consolidation reports of already available parameters for the middle atmosphere would be useful. Atmospheric wind data obtained by rockets and balloons constituted one such parameter which had to be consolidated. The present paper summaries the results of this consolidation study. Both zonal and meridional components of winds at four low latitude Indian stations namely Thumba, Shar, Hyderabad, and Balasore, have been analyzed to yield reference wind profiles for each month. The montly mean values have been used to bring out the amplitudes and phases of the annual, semiannual and quasi-biennial oscillations.

  9. Stable isotopes and their relationship to temperature and precipitation as recorded in low latitude ice cores

    International Nuclear Information System (INIS)

    Thompson, L.G.; Davis, M.E.; Pin-Nan, Lin

    2002-01-01

    The potential of stable isotopic ratios ( 18 O/ 16 O and 2 H/ 1 H) in mid to low latitude glaciers as modern tools for paleoclimate reconstruction is reviewed. The isotopic composition of precipitation should be viewed not only as a powerful proxy indicator of climate, but also as an additional parameter for understanding climate-induced changes in the water cycle, on both regional and global scales. To interpret quantitatively the ice core isotopic records, the response of the isotopic composition of precipitation to long-term fluctuations of key climatic parameters (temperature, precipitation amount, relative humidity) over a given area should be known. Furthermore, it is important to establish the transfer functions that relate the climate-induced changes of the isotopic composition of precipitation to the isotope record preserved in the glacier. The factors that govern the values of stable isotopes in snowfall are enigmatic and as yet no satisfactory model has been developed to link them directly with any one meteorological or oceanographic factor. This is particularly problematic in the high altitude glaciers in the tropics, where complications are present due not only to continental effects, but also to altitude effects and convective air mass instability, particularly in the monsoon climates of the tropics. This paper presents long and short-term perspectives of isotopic composition variations in ice cores spanning the last 25,000 years from the mid- to low-latitude glaciers. The isotopic records will also be examined as a function of the altitude of the individual coring sites which ranges from 5325 meters to 7200 meters. On the short, term isotopic records from ice cores from the Andes of South America, the Tibetan Plateau and Kilimanjaro in Africa through the year 2000 will be presented. All the tropical glaciers for which data exist are disappearing, and these sites show isotopic enrichment in the 20th century that suggests that large scale low latitude

  10. Some studies of zonal and meridional wind characteristics at low latitude Indian stations

    Science.gov (United States)

    Nagpal, O. P.; Kumar, S.

    1985-01-01

    At the beginning of the Indian Middle Atmosphere Programme (IMAP), it was decided that the preparation of consolidation reports of already available parameters for the middle atmosphere would be useful. Atmospheric wind data obtained by rockets and balloons constituted one such parameter which had to be consolidated. The present paper summaries the results of this consolidation study. Both zonal and meridional components of winds at four low latitude Indian stations namely Thumba, Shar, Hyderabad, and Balasore, have been analyzed to yield reference wind profiles for each month. The montly mean values have been used to bring out the amplitudes and phases of the annual, semiannual and quasi-biennial oscillations.

  11. On the cause of IMF By related mid- and low latitude magnetic disturbances

    DEFF Research Database (Denmark)

    Vennerstrøm, Susanne; Christiansen, Freddy; Olsen, Nils

    2007-01-01

    An analysis of the effect of the IMF By on near-Earth low and mid-latitude magnetic disturbances is presented. In particular the contribution from field-aligned currents ( FACs) connected to the polar regions is investigated. Based on statistically determined high-latitude FAC patterns for various...... that the long-distance effect of the high-latitude FACs constitute the major source to IMF By and B-z related magnetic east-west disturbances at mid-and low latitudes....

  12. The presence of the F1 layer over a low latitude station

    International Nuclear Information System (INIS)

    Mosert Gonzalez, M. de; Ezquer, R.; Oviedo, R.V. del

    1996-01-01

    Hourly median values of the ionospheric parameter foF1 observed at a low latitude station, TUCUMAN (26.9 S; 294.6 E) have been compared with those given by the IRI-90 model for years of different solar activity. It is found that, in general, the agreement between the observed and predicted values of foF1 is good when IRI predicts a value for it. Discrepancies are found in the occurrence of the F1 layer, in particular, in winter during low solar activity. (author). 2 refs, 4 figs

  13. Analysis of strong scintillation events by using GPS data at low latitudes

    Science.gov (United States)

    Forte, Biagio; Jakowski, Norbert; Wilken, Volker

    2010-05-01

    Drifting structures charaterised by inhomogeneities in the spatial electron density distribution at ionospheric heights originate scintillation of radio waves propagating through. The fractional electron density fluctuations and the corresponding scintillation levels may reach extreme values at low latitudes during high solar activity. Strong scintillation events have disruptive effects on a number of technological applications. In particular, operations and services based on GPS signals and receivers may experience severe disruption due to a significant degradation of the signal-to-noise ratio, eventually leading to signal loss of lock. Experimental scintillation data collected in the Asian sector at low latitudes by means of a GPS dual frequency receiver under moderate solar activity (2006) have been analysed. The GPS receiver is particularly modified in firmware in order to record power estimates on the C/A code as well as on the carriers L1 and L2. Strong scintillation activity is recorded in the post-sunset period (saturating S4 and SI as high as 20 dB). An overview of these events is presented, by taking into account scintillation impact on the signal intensity, phase, and dynamics. In particular, the interpretation of these events based on a refined scattering theory is provided with possible consequences for standard scintillation models.

  14. Low-latitude plasma drifts from a simulation of the global atmospheric dynamo

    International Nuclear Information System (INIS)

    Crain, D.J.; Heelis, R.A.; Bailey, G.J.; Richmond, A.D.

    1993-01-01

    The authors work with a dynamo model to address questions about plasma drifts in the E region, primarily at low latitudes. Tidal winds have been known to have a big influence on electric fields in the E region, and magnetic fields and ion drifts in the equatorial F region. Recent work has centered on self consistency in simulations, using realistic wind distributions, 3-D current distributions, and more accurate measures of the currents and conductivities. The wind dynamo in the ionosphere is well accepted as the main source of electric fields in the low and mid latitudes. The authors present a self consistent model of the plasma distribution and the dynamo driven electric potential distribution. Their results are compared with other simulations. A major concern in their model was reproducing ion drift observations in the equatorial region. Their conclusion is that the F region plays a significant role in the low latitude dyanamo effects, much larger than was previously assumed. When they build into their model realistic ionospheric conditions, allow for appropriate wind distributions, and allow a self consistent redistribution of plasma in the night, they find the model simulates measured ion drifts more closely. Their model is normalized against observations at Jicamarca. By allowing E x B drifts in the ionosphere, and F region zonal winds they can reproduce many of the night changes in the ion drifts at Jicamarca

  15. Weak Thermocline Mixing in the North Pacific Low-Latitude Western Boundary Current System

    Science.gov (United States)

    Liu, Zhiyu; Lian, Qiang; Zhang, Fangtao; Wang, Lei; Li, Mingming; Bai, Xiaolin; Wang, Jianing; Wang, Fan

    2017-10-01

    Despite its potential importance in the global climate system, mixing properties of the North Pacific low-latitude western boundary current system (LLWBC) remained unsampled until very recently. We report here on the first measurements of turbulence microstructure associated with these currents, made in the western boundary region of the tropical North Pacific east of the Philippines. The results suggest that thermocline mixing in the North Pacific LLWBC is generally weak with the diapycnal diffusivity κρ˜O(10-6) m2 s-1. This is consistent with predictions from internal wave-wave interaction theory that mixing due to internal wave breaking is significantly reduced at low latitudes. Enhanced mixing is found to be associated with a permanent cyclonic eddy, the Mindanao Eddy, but mainly at its south and north flanks. There, κρ is elevated by an order of magnitude due to eddy-induced geostrophic shear. Mixing in the eddy core is at the background level with no indication of enhancement.

  16. Variability of ULF wave power at the magnetopause: a study at low latitude with Cluster data

    Science.gov (United States)

    Cornilleau-Wehrlin, N.; Grison, B.; Belmont, G.; Rezeau, L.; Chanteur, G.; Robert, P.; Canu, P.

    2012-04-01

    Strong ULF wave activity has been observed at magnetopause crossings since a long time. Those turbulent-like waves are possible contributors to particle penetration from the Solar Wind to the Magnetosphere through the magnetopause. Statistical studies have been performed to understand under which conditions the ULF wave power is the most intense and thus the waves can be the most efficient for particle transport from one region to the other. Clearly the solar wind pressure organizes the data, the stronger the pressure, the higher the ULF power (Attié et al 2008). Double STAR-Cluster comparison has shown that ULF wave power is stronger at low latitude than at high latitude (Cornilleau-Wehrlin et al, 2008). The different studies performed have not, up to now, shown a stronger power in the vicinity of local noon. Nevertheless under identical activity conditions, the variability of this power, even at a given location in latitude and local time is very high. The present work intends at understanding this variability by means of the multi spacecraft mission Cluster. The data used are from spring 2008, while Cluster was crossing the magnetopause at low latitude, in particularly quite Solar Wind conditions. The first region of interest of this study is the sub-solar point vicinity where the long wavelength surface wave effects are most unlikely.

  17. Analytical study of nighttime scintillations using GPS at low latitude station Bhopal

    Energy Technology Data Exchange (ETDEWEB)

    Maski, Kalpana, E-mail: k-maski@rediffmail.com [Department of Physics, Regional Institute of Education, Bhopal (India); Vijay, S. K. [Institute for Excellence in Higher Education, Bhopal (India)

    2015-07-31

    Sporadically structured ionosphere (i.e. in-homogeneities in refractive index) can cause fluctuations (due to refraction effects) on the radio signal that is passing through it. These fluctuations are called ionospheric scintillations. Low latitude region is suitable for studying these scintillations. The influence of the ionosphere on the propagation of the radio wave becomes very marked with reference to communication or navigational radio system at very low frequency (VLF) to a high frequency (HF), which operate over the distances of 1000 km or more. Radio wave communication at different frequencies depends on structure of the ionosphere. With the advent of the artificial satellites, they are used as a prime mode of radio wave communication. Some natural perturbation termed as irregularities, are present in the form of electron density of the ionosphere that cause disruption in the radio and satellite communications. Therefore the study of the ionospheric irregularities is of practical importance, if one wishes to understand the upper atmosphere completely. In order to make these communications uninterrupted the knowledge of irregularities, which are present in the ionosphere are very important. These irregularities can be located and estimated with the help of Ionospheric TEC and Scintillation. Scintillation is generally confined to nighttime hours, particularly around equatorial and low latitudes.

  18. Study of ionospheric disturbances over the China mid- and low-latitude region with GPS observations

    Science.gov (United States)

    Ning, Yafei; Tang, Jun

    2018-01-01

    Ionospheric disturbances constitute the main restriction factor for precise positioning techniques based on global positioning system (GPS) measurements. Simultaneously, GPS observations are widely used to determine ionospheric disturbances with total electron content (TEC). In this paper, we present an analysis of ionospheric disturbances over China mid- and low-latitude area before and during the magnetic storm on 17 March 2015. The work analyses the variation of magnetic indices, the amplitude of ionospheric irregularities observed with four arrays of GPS stations and the influence of geomagnetic storm on GPS positioning. The results show that significant ionospheric TEC disturbances occurred between 10:30 and 12:00 UT during the main phase of the large storm, and the static position reliability for this period are little affected by these disturbances. It is observed that the positive and negative disturbances propagate southward along the meridian from mid-latitude to low-latitude regions. The propagation velocity is from about 200 to 700 m s-1 and the amplitude of ionospheric disturbances is from about 0.2 to 0.9 TECU min-1. Moreover, the position dilution of precession (PDOP) with static precise point positioning (PPP) on storm and quiet days is 1.8 and 0.9 cm, respectively. This study is based on the analysis of ionospheric variability with differential rate of vertical TEC (DROVT) and impact of ionospheric storm on positioning with technique of GPS PPP.

  19. Variation of saturation effect in the ionospheric F2 critical frequency at low latitude

    Science.gov (United States)

    Ikubanni, S. O.; Adeniyi, J. O.

    2013-08-01

    Saturation in the dependence of foF2 on solar flux is a phenomenon more pronounced in the equatorial ionization anomaly region. The phenomenon was observed in the relationship between the F2 critical frequency (foF2) and any solar indices. Using a two-segmented regression fit on data from an African low latitude station (Geographical Latitude 12.4°N; Geomagnetic latitude 3.5°N), saturation features from the dependence of foF2 on solar radio flux (F10.7) was studied. Diurnal and seasonal variation were studied for the first time in this low latitude region of the African sector. Significant variations were observed, especially in the solstices. It was observed that saturation effect is closely related to the hourly F2 critical frequency and these results were compared with those from Asian, Australian and the American sectors. The diurnal and seasonal variations find their explanations in the photo-ionization process, the fountain effect, and the pre-reversal enhancement while the seasonal variation was attributed to both the ion drift and thermospheric circulation. Future work with larger volume of data is expected to validate the observations from this study.

  20. NeQuick 2 and IRI Plas VTEC predictions for low latitude and South American sector

    Science.gov (United States)

    Ezquer, R. G.; Scidá, L. A.; Migoya Orué, Y.; Nava, B.; Cabrera, M. A.; Brunini, C.

    2018-04-01

    Using vertical total electron content (VTEC) measurements obtained from GPS satellite signals the capability of the NeQuick 2 and IRI Plas models to predict VTEC over the low latitude and South American sector is analyzed. In the present work both models were used to calculate VTEC up to the height of GPS satellites. Also, comparisons between the performance of IRI Plas and IRI 2007 have been done. The data correspond to June solstice and September equinox 1999 (high solar activity) and they were obtained at nine stations. The considered latitude range extends from 18.4°N to -64.7°N and the longitude ranges from 281.3°E to 295.9°E in the South American sector. The greatest discrepancies among model predictions and the measured VTEC are obtained at low latitudes stations placed in the equatorial anomaly region. Underestimations as strong as 40 TECU [1 TECU = 1016 m-2] can be observed at BOGT station for September equinox, when NeQuick2 model is used. The obtained results also show that: (a) for June solstice, in general the performance of IRI Plas for low latitude stations is better than that of NeQuick2 and, vice versa, for highest latitudes the performance of NeQuick2 is better than that of IRI Plas. For the stations TUCU and SANT both models have good performance; (b) for September equinox the performances of the models do not follow a clearly defined pattern as in the other season. However, it can be seen that for the region placed between the Northern peak and the valley of the equatorial anomaly, in general, the performance of IRI Plas is better than that of NeQuick2 for hours of maximum ionization. From TUCU to the South, the best TEC predictions are given by NeQuick2. The source of the observed deviations of the models has been explored in terms of CCIR foF2 determination in the available ionosonde stations in the region. Discrepancies can be also related to an unrealistic shape of the vertical electron density profile and or an erroneous prediction of

  1. Color-magnitude diagrams for six metal-rich, low-latitude globular clusters

    Science.gov (United States)

    Armandroff, Taft E.

    1988-01-01

    Colors and magnitudes for stars on CCD frames for six metal-rich, low-latitude, previously unstudied globular clusters and one well-studied, metal-rich cluster (47 Tuc) have been derived and color-magnitude diagrams have been constructed. The photometry for stars in 47 Tuc are in good agreement with previous studies, while the V magnitudes of the horizontal-branch stars in the six program clusters do not agree with estimates based on secondary methods. The distances to these clusters are different from prior estimates. Redding values are derived for each program cluster. The horizontal branches of the program clusters all appear to lie entirely redwards of the red edge of the instability strip, as is normal for their metallicities.

  2. Simultaneous Rayleigh lidar and airglow measurements of middle atmospheric waves over low latitudes in India

    Science.gov (United States)

    Taori, A.; Kamalakar, V.; Raghunath, K.; Rao, S. V. B.; Russell, J. M.

    2012-04-01

    We utilize simultaneous Rayleigh lidar and mesospheric OH and O2 airglow measurements to identify the dominant and propagating waves within 40-95 km altitude regions over a low latitude station Gadanki (13.8° N, 79.2 °E). It is found that waves with 0.4-0.6 h periodicity are common throughout the altitude range of 40-95 km with significant amplitudes. The ground based temperature measurements with lidar and airglow monitoring are found to compare well with SABER data. With simultaneous Rayleigh lidar (temperature) and mesospheric airglow (emission intensity and temperature) measurements, we estimate the amplitude growth and Krassovsky parameters to characterize the propagation and dissipation of these upward propagating waves.

  3. Abrupt climate change and high to low latitude teleconnections as simulated in climate models

    DEFF Research Database (Denmark)

    Cvijanovic, Ivana

    of the present day atmospheric mid-latitude energy transport compared to that of the Last Glacial Maximum, suggesting its ability to reorganize more easily and thereby dampen high latitude temperature anomalies that could arise from changes in the oceanic transport. The role of tropical SSTs in the tropical......High to low latitude atmospheric teleconnections have been a topic of increasing scientific interest since it was shown that high latitude extratropical forcing can induce tropical precipitation shifts through atmosphere-surface ocean interactions. In this thesis, several aspects of high to low...... precipitation shifts was further re-examined in idealized simulations with the fixed tropical sea surface temperatures, showing that the SST changes are fundamental to the tropical precipitation shifts. Regarding the high latitude energy loss, it was shown that the main energy compensation comes from...

  4. Assessment of IRI-2016 profile parameters over Indian low latitude station

    Science.gov (United States)

    Patel, Nilesh C.; Karia, Sheetal P.; Pathak, Kamlesh N.

    2018-05-01

    The present study reports the assessment of the bottom-side profile thickness (B0), shape (B1) and F2-peak height (hmF2) parameters IRI-2016 model over the Indian region by using digisonde observations. The digisonde data from a low latitude station Ahmedabad, (located at the crest of the northern equatorial anomaly) during three months June-2012, July-2012 and December-2012 are considered for this study. Simultaneous comparison is made on the performance of three different options `Gul-1987', `Bil-2000' and the `ABT-2009' for the bottom-side profile, three different options`AMTB2013 (AMT)', `SHU-2015 (SHU)', and `BSE-1979 (BSE)' for the hmF2 estimation in the latest available IRI-2016 to that obtained from digisonde measurements. Further, the diurnal characteristics of the B0 and B1 from digisonde measurements are also compared with those from the IRI-2016 model using the three different options.

  5. The electron edge of the low latitude boundary layer during accelerated flow events

    International Nuclear Information System (INIS)

    Gosling, J.T.; Thomsen, M.F.; Bame, S.J.; Onsager, T.G.; Russel, C.T.

    1990-01-01

    Magnetosheath plasma entering the Earth's magnetosphere to populate the low latitude boundary layer, LLBL, is often accelerated to speeds considerably greater than are observed in the adjacent magnetosheath. Measurements made during such accelerated flow events reveal separate electron and ion edges to the LLBL, with the electron edge being found earthward of the ion edge. Plasma electron velocity distributions observed at the earthward edge of the LLBL are often highly structured, exhibiting large asymmetries parallel and antiparallel, as well as perpendicular, to the local magnetic field. These features can consistently be interpreted as time-of-flight effects on recently reconnected field lines, and thus are strong evidence in support of the reconnection interpretation of accelerated plasma flow events

  6. Temporal Behavior of the Ionospheric Electron Density at Low Latitudes: First Glimpse

    Science.gov (United States)

    Gjerloev, J. W.; Humberset, B. K.; Gonzalez, S. A.; Garnett Marques Brum, C.

    2013-12-01

    In this paper we address the spatiotemporal characteristics of the electron density at 150 km altitude in the low latitude ionosphere above the Arecibo Observatory. We utilize a new pointing mode that allows us to probe the same volume in the ionosphere for a continuous period of approximately 25 min. or more. The ISR profiles have 150 m range resolution and samples have a 10-second time resolution; we probed 60 individual regions uniformly spaced in local times and covering the full 24 hours. For each time series we determine the total derivative of the electron density using a narrow Hanning bandpass filter that allow us to determine the variability at different frequencies. This is done for each of the 60 local time regions. We further compare to widely used static statistical models and test their underlying assumption: Dynamics can be ignored.

  7. The effect of vibrationally excited nitrogen on the low-latitude ionosphere

    Directory of Open Access Journals (Sweden)

    B. Jenkins

    1997-11-01

    Full Text Available The first five vibrationally excited states of molecular nitrogen have been included in the Sheffield University plasmasphere ionosphere model. Vibrationally excited molecular nitrogen reacts much more strongly with atomic oxygen ions than ground-state nitrogen; this means that more O+ ions are converted to NO+ ions, which in turn combine with the electrons to give reduced electron densities. Model calculations have been carried out to investigate the effect of including vibrationally excited molecular nitrogen on the low-latitude ionosphere. In contrast to mid-latitudes, a reduction in electron density is seen in all seasons during solar maximum, the greatest effect being at the location of the equatorial trough.

  8. On the observations of unique low latitude whistler-triggered VLF/ELF emissions

    Science.gov (United States)

    Altaf, M.; Singh, K. K.; Singh, A. K.; Lalmani

    A detailed analysis of the VLF/ELF wave data obtained during a whistler campaign under All India Coordinated Program of Ionosphere Thermosphere Studies (AICPITS) at our low latitude Indian ground station Jammu (geomag. lat. = 22° 26‧ N, L = 1.17) has yielded two types of unusual and unique whistler-triggered VLF/ELF emissions. These include (1) whistler-triggered hook emissions and (2) whistler-triggered long enduring discrete chorus riser emissions in VLF/ELF frequency range during night time. Such types of whistler-triggered emissions have not been reported earlier from any of the ground observations at low latitudes. In the present study, the observed characteristics of these emissions are described and interpreted. Dispersion analysis of these emissions show that the whistlers as well as emissions have propagated along a higher geomagnetic field line path with L-values lying ∼L = 4, suggesting that these triggered emissions are to be regarded as mid-latitude emissions. These waves could have propagated along the geomagnetic field lines either in a ducted mode or in a pro-longitudinal (PL) mode. The measured intensity of the triggered emissions is almost equal to that of the source waves and does not vary throughout the period of observation on that day. It is speculated that these emissions may have been generated through a process of resonant interaction of the whistler waves with energetic electrons. Parameters related to this interaction are computed for different values of L and wave amplitude. The proposed mechanism explains some aspects of the dynamic spectra.

  9. Chandra X-ray Observations of Jovian Low-latitude Emissions: Morphological, Temporal, and Spectral Characteristics

    Science.gov (United States)

    Bhardwaj, Anil; Elsner, Ronald F.; Gladstone, G. Randall; Cravens, Thomas E.; Waiate J. Hunter, Jr.; Branduardi-Raymont, Graziella; Ford, Peter

    2004-01-01

    Chandra observed X-rays from Jupiter during 24-26 February 2003 for about 40 hours with the ACIS-S and HRC-I instruments. The analysis of Jovian low-latitude "disk" Xray emissions are presented and compared with the high-latitude "auroral" emissions. We report the first Chandra ACIS-S measured X-ray spectrum (0.3-2 keV) of Jupiter's low-latitude disk The disk X-ray emission is harder and extends to higher energies than the auroral spectrum. The temporal variation in the Jovian disk X-rays is on an average consistent with those in the solar X-rays observed by GOES, and TIMED/SSE. Contrary to the auroral X-rays, the disk emissions are uniformly distributed over Jupiter; no indication of longitudinal dependence or correlation with surface magneh field strength is visible. Also, unlike the approx. 40 +/- 20 min periodic oscillations seen in the auroral X-ray emissions, the disk emissions do not show any periodic oscillations. The disk spectrum seems to be consistent with resonant and fluorescent scattering of solar X-rays by the Jovian upper atmosphere. Jupiter's disk is found to be about 50% dimmer in soft X-rays in February 2003 compared that in December 2000, which is consistent with the decrease in solar activity. No evidence of lightning-induced X-rays is seen in the Chandra X-ray data. The Jovian disk spectra observed with Chandra-ACIS is stronger than that observed with XMM-Newton two months later during April 28-29, 2003. The XMM-Newton Xray image of Jupiter shows evidence of limb darkening on the anti-sunward side as seen from Earth, as well as an asymmetry with respect to the subsolar point: suggesting a solar driven process.

  10. Coordinated observations of postmidnight irregularities and thermospheric neutral winds and temperatures at low latitudes

    Science.gov (United States)

    Dao, Tam; Otsuka, Yuichi; Shiokawa, Kazuo; Nishioka, Michi; Yamamoto, Mamoru; Buhari, Suhaila M.; Abdullah, Mardina; Husin, Asnawi

    2017-07-01

    We investigated a postmidnight field-aligned irregularity (FAI) event observed with the Equatorial Atmosphere Radar at Kototabang (0.2°S, 100.3°E, dip latitude 10.4°S) in Indonesia on the night of 9 July 2010 using a comprehensive data set of both neutral and plasma parameters. We examined the rate of total electron content change index (ROTI) obtained from GPS receivers in Southeast Asia, airglow images detected by an all-sky imager, and thermospheric neutral winds and temperatures obtained by a Fabry-Perot interferometer at Kototabang. Altitudes of the F layer (h'F) observed by ionosondes at Kototabang, Chiang Mai, and Chumphon were also surveyed. We found that the postmidnight FAIs occurred within plasma bubbles and coincided with kilometer-scale plasma density irregularities. We also observed an enhancement of the magnetically equatorward thermospheric neutral wind at the same time as the increase of h'F at low-latitude stations, but h'F at a station near the magnetic equator remained invariant. Simultaneously, a magnetically equatorward gradient of thermospheric temperature was identified at Kototabang. The convergence of equatorward neutral winds from the Northern and Southern Hemispheres could be associated with a midnight temperature maximum occurring around the magnetic equator. Equatorward neutral winds can uplift the F layer at low latitudes and increase the growth rate of Rayleigh-Taylor instabilities, causing more rapid extension of plasma bubbles. The equatorward winds in both hemispheres also intensify the eastward Pedersen current, so a large polarization electric field generated in the plasma bubble might play an important role in the generation of postmidnight FAIs.

  11. A simulation study of the vortex structure in the low-latitude boundary layer

    International Nuclear Information System (INIS)

    Wei, C.Q.; Lee, L.C.; La Belle-Hamer, A.L.

    1990-01-01

    Satellite observations indicate that the plasma density and the flow velocity are highly variable in the low-latitude boundary layer. The thickness of the boundary layer is also highly variable and appears to increase with increasing longitudinal distance from the subsolar point. In this paper plasma dynamics in the low-latitude boundary layer region is studied on the basis of a two-dimensional incompressible bydrodynamic numerical model. In the simulation, plasma is driven into the boundary layer region by imposing a diffusion flux along the magnetopause. The vortex motions associated with the Kelvin-Helmholtz instability are observed in the simulation. The resulting vortex structures in the plasma density and the flow velocity may coalesce as they are convected tailward, causing them to grow in size. The boundary layer thickness increases with increasing longitudinal distance from the subsolar point in accord with satellite observations. The plasma density and the flow velocity are positively correlated. A mixing region is formed where magnetosheath plasma and magnetospheric plasma mix due to the vortex motions. In the later stage of development, a density plateau is formed in the central part of the boundary layer. Many features of the satellite observations of the boundary layer can be explained using the numerical model. The simulation results also predict that the vortices generated in the postnoon (prenoon) boundary layer lead to the presence of localized upward (downward) field-aligned currents in both the northern and the southern polar ionospheres. The upward field-aligned currents in turn may lead to the formation of dayside auroral patches observed in the postnoon region

  12. First mesospheric turbulence study using coordinated rocket and MST radar measurements over Indian low latitude region

    Directory of Open Access Journals (Sweden)

    H. Chandra

    2008-09-01

    Full Text Available A campaign to study turbulence in the mesosphere, over low latitudes in India, using rocket-borne measurements and Indian MST radar, was conducted during July 2004. A rocket-borne Langmuir probe detected a spectrum of electron density irregularities, with scale sizes in the range of about 1 m to 1 km, in 67.5–78.0 km and 84–89 km altitude regions over a low latitude station Sriharikota (13.6° N, 80.2° E. A rocket-borne chaff experiment measured zonal and meridional winds about 30 min after the Langmuir probe flight. The MST radar located at Gadanki (13.5° N, 79.2° E, which is about 100 km west of Sriharikota, also detected the presence of a strong scattering layer in 73.5–77.5 km region from which radar echoes corresponding to 3 m irregularities were received. Based on the region of occurrence of irregularities, which was highly collisional, presence of significant shears in zonal and meridional components of wind measured by the chaff experiment, 10 min periodicity in zonal and meridional winds obtained by the MST radar and the nature of wave number spectra of the irregularities, it is suggested that the observed irregularities were produced through the neutral turbulence mechanism. The percentage amplitude of fluctuations across the entire scale size range showed that the strength of turbulence was stronger in the lower altitude regions and decreased with increasing altitude. It was also found that the amplitude of fluctuations was large in regions of steeper electron density gradients. MST radar observations showed that at smaller scales of turbulence such as 3 m, (a the thickness of the turbulent layer was between 2 and 3 km and (b and fine structures, with layer thicknesses of about a km or less were also embedded in these layers. Rocket also detected 3-m fluctuations, which were very strong (a few percent in lower altitudes (67.5 to 71.0 km and small but clearly well above the noise floor at higher altitudes. Rocket and radar

  13. First mesospheric turbulence study using coordinated rocket and MST radar measurements over Indian low latitude region

    Energy Technology Data Exchange (ETDEWEB)

    Chandra, H.; Sinha, H.S.S.; Das, U.; Misra, R.N.; Das, S.R. [Physical Research Lab., Ahmedabad (India); Datta, J.; Chakravarty, S.C. [ISRO Headquarters, Bangalore (India); Patra, A.K.; Vekateswara Rao, N.; Narayana Rao, D. [National Atmospheric Research Lab., Tirupati (India)

    2008-07-01

    A campaign to study turbulence in the mesosphere, over low latitudes in India, using rocket-borne measurements and Indian MST radar, was conducted during July 2004. A rocket-borne Langmuir probe detected a spectrum of electron density irregularities, with scale sizes in the range of about 1 m to 1 km, in 67.5-78.0 km and 84-89 km altitude regions over a low latitude station Sriharikota (13.6 N, 80.2 E). A rocket-borne chaff experiment measured zonal and meridional winds about 30 min after the Langmuir probe flight. The MST radar located at Gadanki (13.5 N, 79.2 E), which is about 100 km west of Sriharikota, also detected the presence of a strong scattering layer in 73.5-77.5 km region from which radar echoes corresponding to 3 m irregularities were received. Based on the region of occurrence of irregularities, which was highly collisional, presence of significant shears in zonal and meridional components of wind measured by the chaff experiment, 10 min periodicity in zonal and meridional winds obtained by the MST radar and the nature of wave number spectra of the irregularities, it is suggested that the observed irregularities were produced through the neutral turbulence mechanism. The percentage amplitude of fluctuations across the entire scale size range showed that the strength of turbulence was stronger in the lower altitude regions and decreased with increasing altitude. It was also found that the amplitude of fluctuations was large in regions of steeper electron density gradients. MST radar observations showed that at smaller scales of turbulence such as 3 m, (a) the thickness of the turbulent layer was between 2 and 3 km and (b) and fine structures, with layer thicknesses of about a km or less were also embedded in these layers. Rocket also detected 3-m fluctuations, which were very strong (a few percent) in lower altitudes (67.5 to 71.0 km) and small but clearly well above the noise floor at higher altitudes. Rocket and radar results also point to the

  14. Low-latitude scintillation occurrences around the equatorial anomaly crest over Indonesia

    Directory of Open Access Journals (Sweden)

    P. Abadi

    2014-01-01

    Full Text Available We investigated low-latitude ionospheric scintillation in Indonesia using two GPS receivers installed at Bandung (107.6° E, 6.9° S; magnetic latitude 17.5° S and Pontianak (109.3° E, 0.02° S; magnetic latitude 8.9° S. This study aimed to characterise climatological and directional ionospheric scintillation occurrences, which are useful not only for the physics of ionospheric irregularities but also for practical use in GNSS (global navigation satellite system-based navigation. We used the deployed instrument's amplitude scintillation (S4 index data from 2009, 2010, and 2011; the yearly SSN (sunspot-smoothed numbers were 3.1, 16.5, and 55.9, respectively. In summary, (1 scintillation occurrences in the post-sunset period (18:00–01:00 LT during equinox months (plasma bubble season at the two sites can be ascribed to the plasma bubble; (2 using directional analyses of the two sites, we found that the distribution of scintillation occurrences is generally concentrated between the two sites, indicating the average location of the EIA (equatorial ionisation anomaly crest; (3 scintillation occurrence enhancements for the two sites in field-aligned directions are herein reported for the first time by ground-based observation in a low-latitude region; (4 distribution of scintillation occurrences at Pontianak are concentrated in the southern sky, especially in the southwest direction, which is very likely associated with the plasma bubble tilted westward with increasing latitude; and (5 scintillation occurrence in the post-midnight period in the non-plasma-bubble season is the most intriguing variable occurring between the two sites (i.e. post-midnight scintillations are observed more at Bandung than Pontianak. Most of the post-midnight scintillations observed at Bandung are concentrated in the northern sky, with low elevation angles. This might be due to the amplitude of irregularities in certain directions, which may be effectively enhanced by

  15. Characterization of the low latitude plasma density irregularities observed using C/NOFS and SCINDA data

    Science.gov (United States)

    Andima, Geoffrey; Amabayo, Emirant B.; Jurua, Edward; Cilliers, Pierre J.

    2018-01-01

    Complex electrodynamic processes over the low latitude region often result in post sunset plasma density irregularities which degrade satellite communication and navigation. In order to forecast the density irregularities, their occurrence time, duration and location need to be quantified. Data from the Communication/Navigation Outage Forecasting System (C/NOFS) satellite was used to characterize the low latitude ion density irregularities from 2011 to 2013. This was supported by ground based data from the SCIntillation Network Decision Aid (SCINDA) receivers at Makerere (Geographic coordinate 32.6°E, 0.3°N, and dip latitude -9.3°N) and Nairobi (Geographic coordinate 36.8°E, -1.3°N, and dip latitude -10.8°N). The results show that irregularities in ion density have a daily pattern with peaks from 20:00 to 24:00 Local Time (LT). Scintillation activity at L band and VHF over East Africa peaked in 2011 and 2012 from 20:00 to 24:00 LT, though in many cases scintillation at VHF persisted longer than that at L band. A longitudinal pattern in ion density irregularity occurrence was observed with peaks over 135-180°E and 270-300°E. The likelihood of ion density irregularity occurrence decreased with increasing altitude. Analysis of C/NOFS zonal ion drift velocities showed that the largest nighttime and daytime drifts were in 270-300°E and 300-330°E longitude regions respectively. Zonal irregularity drift velocities over East Africa were for the first time estimated from L-band scintillation indices. The results show that the velocity of plasma density irregularities in 2011 and 2012 varied daily, and hourly in the range of 50-150 m s-1. The zonal drift velocity estimates from the L-band scintillation indices had good positive correlation with the zonal drift velocities derived from VHF receivers by the spaced receiver technique.

  16. Combined TOPEX/Poseidon TEC and ionosonde observations of negative low-latitude ionospheric storms

    Directory of Open Access Journals (Sweden)

    K. J. W. Lynn

    2004-09-01

    Full Text Available Ionospheric storms showing a strong depression in daytime foF2 values were sought which penetrated to low-latitudes, as identified by vertical ionosondes operating at Darwin and Townsville over the period 1992-1998. The 32 storms thus identified showed a seasonal occurrence peaking near the equinoxes with a bias to the summer side. Of these storms, three (27 March 1995, 25 October 1997, 8 November 1997 combined Australian and South East Asian ionosonde observations with local afternoon TOPEX/Poseidon measurements of TEC. The equatorial anomaly is usually well developed at this time of day and consequently these storms were chosen for detailed study. The TOPEX/Poseidon satellite provided vertical profiles of the ionosphere across both hemispheres, thus allowing the totality of storm behaviour to be observed for the first time at low-latitudes and related directly to the ionosonde observations. The three storms were remarkably consistent in their behaviour, the negative ionospheric storm day followed some 24-36h after the beginning of a magnetic storm and the development of the equatorial anomaly was suppressed. However, the suppression of the equatorial anomaly was not the main cause of the strong depression in foF2 observed by the Southern Hemisphere ionosondes. The latter was associated with an additional bite-out in both TEC and foF2 that occurred on the southern side of the magnetic equator. None of the three storms produced any major negative disturbance outside the range of normal variability of TEC and foF2 at the northern latitude sites for which data was available, despite the absence of the anomaly. The satellite measurements show the strength of the anomaly to be highly variable from day-to-day and anomaly peaks are frequently not present even on magnetically quiet days. Thus, an absence of anomaly peaks is contained within the normal variability of non-storm days. The north-south asymmetry and seasonal occurrence are consistent with

  17. How Strong is the Case for Proterozoic Low-Latitude Glaciation?

    Science.gov (United States)

    Evans, D. A.

    2004-05-01

    The most recent global compilations of paleomagnetic depositional latitudes for Proterozoic glaciogenic formations indicate a dominant mode near the paleo-equator (Evans 2000 AJS; Evans 2003 Tectonophysics). This result would therefore support either the snowball Earth or the large-obliquity hypotheses for Precambrian ice ages, but would reject the uniformitarian comparison to polar-temperate-restricted Phanerozoic glaciogenic deposits. The most reliable low-latitude results come from the Australian Marinoan succession, but a recent summary of these units has suggested that a glaciogenic origin is not yet demonstrated (Eyles and Januszczak 2004 Earth-Sci Reviews). It becomes useful, then, to review the global evidence for Proterozoic low-latitude glaciation. Eyles and Januszczak (ibid.) identified 13 Neoproterozoic deposits with "demonstrated" glacial influence. Among these, poor age constraints and lack of paleomagnetic data prohibit estimation of depositional paleolatitudes for the Fiq, Sturtian, Vreeland, Taoudeni, East Greenland, Port Askaig, and Zhengmuguan units. Moderate paleolatitudes are reasonably well supported for the South China, Gaskiers, Smalfjord, and Moelv units. Among the three remaining units, the Rapitan Group can be assigned a near-equatorial paleolatitude indirectly through use of the Galeros and Franklin-Natkusiak paleomagnetic results, as long as the Rapitan age lies within 750-720 Ma as generally expected. The Moonlight Valley Formation in northern Australia may be assigned a tropical paleolatitude according to high-quality paleomagnetic results from compellingly correlated Marinoan strata in southern Australia. Those strata, including the famous Elatina Formation, have yielded a robust paleomagnetic signature that is commonly interpreted to imply frigid climate (manifest in part by frost-wedge polygons) at near-equatorial latitudes. Concerns that the Neoproterozoic geomagnetic field was either nonaxial or nondipolar are valid in principle

  18. Support for equatorial anisotropy of Earth's inner-inner core from seismic interferometry at low latitudes

    Science.gov (United States)

    Wang, Tao; Song, Xiaodong

    2018-03-01

    Anisotropy of Earth's inner core provides a key role to understand its evolution and the Earth's magnetic field. Recently, using autocorrelations from earthquake's coda, we found an equatorial anisotropy of the inner-inner core (IIC), in apparent contrast to the polar anisotropy of the outer-inner core (OIC). To reduce the influence of the polar anisotropy and reduce possible contaminations from the large Fresnel zone of the PKIKP2 and PKIIKP2 phases at low frequencies, we processed coda noise of large earthquakes (10,000-40,000 s after magnitude ≥7.0) from stations at low latitudes (within ±35°) during 1990-2013. Using a number of improved procedures of both autocorrelation and cross-correlation, we extracted 52 array-stacked high-quality empirical Green's functions (EGFs), an increase of over 60% from our previous study. The high-quality data allow us to measure the relative arrival times by automatic waveform cross correlation. The results show large variation (∼10.9 s) in the differential times between the PKIKP2 and PKIIKP2 phases. The estimated influence of the Fresnel zone is insignificant (core history, change of geomagnetic field, and a proto-inner core.

  19. Simultaneous VHF radar backscatter and ionosonde observations of low-latitude E region

    Directory of Open Access Journals (Sweden)

    A. K. Patra

    2005-03-01

    Full Text Available The first results of simultaneous observations made on the low-latitude field-aligned irregularities (FAI using the MST radar located at Gadanki (13.5° N, 79.2° E, dip 12.5° and the Es parameters using an ionosonde at a nearby station Sriharikota (13.7° N, 80.1° E, dip 12.6° are presented. The observations show that while the height of the most intense radar echoes is below the virtual height of Es (h'Es during daytime, it is found to be either below or above during nighttime. The strength of the FAI is better correlated with the top penetration frequency (ftEs and the blanketing frequency (fbEs during the night (r=0.4 in both cases as compared to the day (r=0.35 and -0.04, respectively. Furthermore, the signal strength of FAI is reasonably correlated with (ftEs-fbEs during daytime (r=0.59 while very poorly correlated during nighttime (r=0.18. While the radar observations in general appear to have characteristics close to that of mid-latitudes, the relationship of these with the Es parameters are poorer than that of mid-latitudes. The observations reported here, nevertheless, are quite consistent with the expectations based on the gradient drift instability mechanism.

  20. Plasma structure near the low-latitude boundary layer: A rebuttal

    International Nuclear Information System (INIS)

    Sckopke, N.

    1991-01-01

    A recent reanalysis of a well-documented interval of plasma and magnetic field data led its authors to offer a new model for the structure of the outer magnetosphere and the magnetosheath on the northern dawnside. On November 6, 1977, ISEE 1 and 2 had observed a series of quasi-periodic pulses of magnetosheath-like plasma on northward oriented magnetic field lines which were originally interpreted as repeated encounters of a pulsed low-latitude boundary layer inside a smooth magnetopause followed by a single outward crossing of the magnetopause. D.G. Sibeck and coworkers reinterpreted the ISEE observations as being due to quasi-periodic magnetopause motion causing the satellites to repeatedly exit the magnetosphere and to observe draped northward magnetosheath magnetic field lines in the plasma depletion layer. Their model is based on qualitative arguments concerning the amount of field line draping in the magnetosheath as well as the behavior of energetic electrons near the magnetopause. It is shown in this paper that both arguments are not in accordance with the available evidence

  1. One second vector and scalar magnetic measurements at the low-latitude Choutuppal (CPL) magnetic observatory

    Science.gov (United States)

    Phani Chandrasekhar, Nelapatla; Potharaju, Sai Vijay Kumar; Arora, Kusumita; Shakar Rao Kasuba, Chandra; Rakhlin, Leonid; Tymoshyn, Sergey; Merenyi, Laszlo; Chilukuri, Anusha; Bulusu, Jayashree; Khomutov, Sergey

    2017-12-01

    One second measurements of the geomagnetic field variations, which meet INTERMAGNET quality and transmission specifications, require very special conditions to be maintained at the observatories over sustained periods of time, which pose serious challenges for the operators, particularly when infrastructural and environmental conditions are far from ideal. This work presents the progressive steps, which led to the successful setup of such measurements at the new magnetic observatory of the Council of Scientific and Industrial Research (CSIR)-National Geophysical Research Institute (NGRI) in the Choutuppal (CPL) campus, Hyderabad (HYB), India. The 1 s magnetic measurements in trial mode commenced in 2015 using the newly developed observatory-grade 1 s fluxgate magnetometer, GEOMAG-02MO, from Research Centre GEOMAGNET (GM), Ukraine, and the Overhauser proton precession magnetometer, GSM-90F1, along with the data acquisition system, Magrec-4B from Mingeo, Hungary. Iterative tuning of the setup led to the generation of good quality data from 2016 onward. The processes of commissioning this setup in low-latitude conditions, with the aim of producing 1 s definitive data, and the characteristics of the data from this new instrument are presented here.

  2. One second vector and scalar magnetic measurements at the low-latitude Choutuppal (CPL magnetic observatory

    Directory of Open Access Journals (Sweden)

    N. Phani Chandrasekhar

    2017-12-01

    Full Text Available One second measurements of the geomagnetic field variations, which meet INTERMAGNET quality and transmission specifications, require very special conditions to be maintained at the observatories over sustained periods of time, which pose serious challenges for the operators, particularly when infrastructural and environmental conditions are far from ideal. This work presents the progressive steps, which led to the successful setup of such measurements at the new magnetic observatory of the Council of Scientific and Industrial Research (CSIR-National Geophysical Research Institute (NGRI in the Choutuppal (CPL campus, Hyderabad (HYB, India. The 1 s magnetic measurements in trial mode commenced in 2015 using the newly developed observatory-grade 1 s fluxgate magnetometer, GEOMAG-02MO, from Research Centre GEOMAGNET (GM, Ukraine, and the Overhauser proton precession magnetometer, GSM-90F1, along with the data acquisition system, Magrec-4B from Mingeo, Hungary. Iterative tuning of the setup led to the generation of good quality data from 2016 onward. The processes of commissioning this setup in low-latitude conditions, with the aim of producing 1 s definitive data, and the characteristics of the data from this new instrument are presented here.

  3. Characteristics of Low-latitude Coronal Holes near the Maximum of Solar Cycle 24

    Energy Technology Data Exchange (ETDEWEB)

    Hofmeister, Stefan J.; Veronig, Astrid; Reiss, Martin A.; Temmer, Manuela [University of Graz, Institute of Physics, IGAM-Kanzelhöhe Observatory, Graz (Austria); Vennerstrom, Susanne [National Space Institute, DTU Space (Denmark); Vršnak, Bojan [Hvar Observatory, Faculty of Geodesy, Zagreb (Croatia); Heber, Bernd, E-mail: stefan.hofmeister@uni-graz.at [Universität Kiel, Institut für Experimentelle und Angewandte Physik, Kiel (Germany)

    2017-02-01

    We investigate the statistics of 288 low-latitude coronal holes extracted from SDO /AIA-193 filtergrams over the time range of 2011 January 01–2013 December 31. We analyze the distribution of characteristic coronal hole properties, such as the areas, mean AIA-193 intensities, and mean magnetic field densities, the local distribution of the SDO /AIA-193 intensity and the magnetic field within the coronal holes, and the distribution of magnetic flux tubes in coronal holes. We find that the mean magnetic field density of all coronal holes under study is 3.0 ± 1.6 G, and the percentaged unbalanced magnetic flux is 49 ± 16%. The mean magnetic field density, the mean unsigned magnetic field density, and the percentaged unbalanced magnetic flux of coronal holes depend strongly pairwise on each other, with correlation coefficients cc > 0.92. Furthermore, we find that the unbalanced magnetic flux of the coronal holes is predominantly concentrated in magnetic flux tubes: 38% (81%) of the unbalanced magnetic flux of coronal holes arises from only 1% (10%) of the coronal hole area, clustered in magnetic flux tubes with field strengths >50 G (10 G). The average magnetic field density and the unbalanced magnetic flux derived from the magnetic flux tubes correlate with the mean magnetic field density and the unbalanced magnetic flux of the overall coronal hole (cc>0.93). These findings give evidence that the overall magnetic characteristics of coronal holes are governed by the characteristics of the magnetic flux tubes.

  4. Reassessment of the thermospheric response to geomagnetic activity at low latitudes

    International Nuclear Information System (INIS)

    Berger, C.; Barlier, F.; Ill, M.

    1988-01-01

    The present study takes advantage of measurements made at low latitudes by the Cactus accelerometer. From such measurements the response of several thermospheric parameters to geomagnetic activity can be simultaneously and reliably retrieved: total density, density scale height, vertical density scale height gradient, temperature, O/N 2 ratio and mean molecular mass. On investigation their behaviour exhibits a diurnal variation, some features of which have not been described, especially in the case of strong geomagnetic storms. In particular, the night scale height response appears to be stronger than the day one while its vertical gradients increase by day and slightly decrease at night. The temperature increase is higher by day while the O/N 2 ratio decreases by day, and increases at night at constant pressure level as well as at fixed height. By day, significant vertical temperature gradients are also found. These results as well as others are analysed in the light of existing theories and compared to the predictions of existing thermospheric models. Strong meridional winds at night, heat transport through thermal conductivity as well as wave dissipation during the day might be factors helping to account for such a behaviour

  5. Surface-temperature trends and variability in the low-latitude North Atlantic since 1552

    KAUST Repository

    Saenger, Casey; Cohen, Anne L.; Oppo, Delia W.; Halley, Robert B.; Carilli, Jessica E.

    2009-01-01

    Sea surface temperature variability in the North Atlantic Ocean recorded since about 1850 has been ascribed to a natural multidecadal oscillation superimposed on a background warming trend1-6. It has been suggested that the multidecadal variability may be a persistent feature6-8, raising the possibility that the associated climate impacts may be predictable7,8. owever, our understanding of the multidecadal ocean variability before the instrumental record is based on interpretations of high-latitude terrestrial proxy records. Here we present an absolutely dated and annually resolved record of sea surface temperature from the Bahamas, based on a 440-year time series of coral growth rates. The reconstruction indicates that temperatures were as warm as today from about 1552 to 1570, then cooled by about 1° C from 1650 to 1730 before warming until the present. Our estimates of background variability suggest that much of the warming since 1900 was driven by anthropogenic forcing. Interdecadal variability with a period of 15-25 years is superimposed on most of the record, but multidecadal variability becomes significant only after 1730. We conclude that the multidecadal variability in sea surface temperatures in the low-latitude western Atlantic Ocean may not be persistent, potentially making accurate decadal climate forecasts more difficult to achieve. © 2009 Macmillan Publishers Limited. All rights reserved.

  6. Surface-temperature trends and variability in the low-latitude North Atlantic since 1552

    KAUST Repository

    Saenger, Casey

    2009-06-21

    Sea surface temperature variability in the North Atlantic Ocean recorded since about 1850 has been ascribed to a natural multidecadal oscillation superimposed on a background warming trend1-6. It has been suggested that the multidecadal variability may be a persistent feature6-8, raising the possibility that the associated climate impacts may be predictable7,8. owever, our understanding of the multidecadal ocean variability before the instrumental record is based on interpretations of high-latitude terrestrial proxy records. Here we present an absolutely dated and annually resolved record of sea surface temperature from the Bahamas, based on a 440-year time series of coral growth rates. The reconstruction indicates that temperatures were as warm as today from about 1552 to 1570, then cooled by about 1° C from 1650 to 1730 before warming until the present. Our estimates of background variability suggest that much of the warming since 1900 was driven by anthropogenic forcing. Interdecadal variability with a period of 15-25 years is superimposed on most of the record, but multidecadal variability becomes significant only after 1730. We conclude that the multidecadal variability in sea surface temperatures in the low-latitude western Atlantic Ocean may not be persistent, potentially making accurate decadal climate forecasts more difficult to achieve. © 2009 Macmillan Publishers Limited. All rights reserved.

  7. Ocean-driven heating of Europa's icy shell at low latitudes

    Science.gov (United States)

    Soderlund, K. M.; Schmidt, B. E.; Wicht, J.; Blankenship, D. D.

    2014-01-01

    The ice shell of Jupiter's moon Europa is marked by regions of disrupted ice known as chaos terrains that cover up to 40% of the satellite's surface, most commonly occurring within 40° of the equator. Concurrence with salt deposits implies a coupling between the geologically active ice shell and the underlying liquid water ocean at lower latitudes. Europa's ocean dynamics have been assumed to adopt a two-dimensional pattern, which channels the moon's internal heat to higher latitudes. Here we present a numerical model of thermal convection in a thin, rotating spherical shell where small-scale convection instead adopts a three-dimensional structure and is more vigorous at lower latitudes. Global-scale currents are organized into three zonal jets and two equatorial Hadley-like circulation cells. We find that these convective motions transmit Europa's internal heat towards the surface most effectively in equatorial regions, where they can directly influence the thermo-compositional state and structure of the ice shell. We suggest that such heterogeneous heating promotes the formation of chaos features through increased melting of the ice shell and subsequent deposition of marine ice at low latitudes. We conclude that Europa's ocean dynamics can modulate the exchange of heat and materials between the surface and interior and explain the observed distribution of chaos terrains.

  8. A study of the effect of geomagnetic storms on low latitude whistlers

    International Nuclear Information System (INIS)

    Rao, Manoranjan; Somayajulu, V.V.; Dikshit, S.K.

    1974-01-01

    This paper presents the results of a detailed study of the influence of geomagnetic storms on low latitude whistlers recorded on ground. Studied in detail is the effect of the geomagnetic storm of March 6-10, 1970 on whistlers recorded at Gulmarg (Geomagnetic coordinates: 24 0 10'N; 147 0 24'E); results of analysis for the earlier storm of January 13-15, 1967 are included for comparison. Some of the important results of the present study are: (i) Both the whistler occurrence rate and dispersion increase simultaneously with Kp, (ii) During the decaying phase of the storm, changes in occurrence rate and in dispersion lag behind those in Kp, (iii) There is an indication of the existence of a cross-over latitude where tube contents may not change appreciably during storm periods, (iv) Multipath whistlers are observed only during disturbed conditions, (v) Duct life ranges between several hours to few days and (vi) Maximum number of ducts is observed during the main and recovery phases of the storm. (auth.)

  9. Storm-time ionization enhancements at the topside low-latitude ionosphere

    Directory of Open Access Journals (Sweden)

    A. Dmitriev

    2008-05-01

    Full Text Available Ion density enhancements at the topside low-latitude ionosphere during a Bastille storm on 15–16 July 2000 and Halloween storms on 29–31 October 2003 were studied using data from ROCSAT-1/IPEI experiment. Prominent ion density enhancements demonstrate similar temporal dynamics both in the sunlit and in the nightside hemispheres. The ion density increases dramatically (up to two orders of magnitude during the main phase of the geomagnetic storms and reaches peak values at the storm maximum. The density enhancements are mostly localized in the region of a South Atlantic Anomaly (SAA, which is characterized by very intense fluxes of energetic particles. The dynamics of near-Earth radiation was studied using SAMPEX/LEICA data on >0.6 MeV electrons and >0.8 MeV protons at around 600 km altitude. During the magnetic storms the energetic particle fluxes in the SAA region and in its vicinity increase more than three orders of magnitude. The location of increased fluxes overlaps well with the regions of ion density enhancements. Two mechanisms were considered to be responsible for the generation of storm-time ion density enhancements: prompt penetration of the interplanetary electric field and abundant ionization of the ionosphere by enhanced precipitation of energetic particles from the radiation belt.

  10. Dedicated Low Latitude Diurnal CO2 Frost Observation Campaigns by the Mars Climate Sounder

    Science.gov (United States)

    Piqueux, S.; Kass, D. M.; Kleinboehl, A.; Hayne, P. O.; Heavens, N. G.; McCleese, D. J.; Schofield, J. T.; Shirley, J. H.

    2017-12-01

    In December 2016 (Ls≈280, MY33) and July 2017 (Ls≈30, MY34), the Mars Climate Sounder (MCS) onboard the Mars Reconnaissance Orbiter (MRO) conducted two distinct observation campaigns. The first one aimed at 1) confirming the presence of low latitude diurnal CO2 frost on Mars, and 2) refining the estimated mass of carbon dioxide condensed at the surface, whereas the second campaign was designed to 3) search for temporally and spatially varying spectral characteristics indicative of frost properties (i.e., crystal size, contamination, etc.) and relationship to the regolith. To meet these goals, MCS acquired thermal infrared observations of the surface and atmosphere at variable local times (≈1.70-3.80 h Local True Solar Time) and in the 10°-50°N latitude band where very low thermal inertia material (frost distribution and spectral properties. In addition, pre-frost deposition surface cooling rates are found to be consistent with those predicted by numerical models (i.e., 1-2K per hour). Finally, we observe buffered surface temperatures near the local frost point, indicating a surface emissivity ≈1. (i.e., optically thin frost layers, or dust contaminated frost, or slab-like ice) and no discernable frost metamorphism. We will present a detailed analysis of these new and unique observations, and elaborate on the potential relationship between the regolith and this recurring frost cycle.

  11. The inland boundary layer at low latitudes: II Sea-breeze influences

    Science.gov (United States)

    Garratt, J. R.; Physick, W. L.

    1985-11-01

    Two-dimensional mesoscale model results support the claim of evening sea-breeze activity at Daly Waters, 280 km inland from the coast in northern Australia, the site of the Koorin boundary-layer experiment. The sea breeze occurs in conditions of strong onshore and alongshore geostrophic winds, not normally associated with such activity. It manifests itself at Daly Waters and in the model as a cooling in a layer 500 1000 m deep, as an associated surface pressure jump, as strong backing of the wind and, when an offshore low-level wind is present, as a collapse in the inland nocturnal jet. Both observational analysis and model results illustrate the rotational aspects of the deeply penetrating sea breeze; in our analysis this is represented in terms of a surge vector — the vector difference between the post- and pre-frontal low-level winds. There is further evidence to support earlier work that the sea breeze during the afternoon and well into the night — at least for these low-latitude experiments — behaves in many ways as an atmospheric gravity current, and that inland penetrations up to 500 km occur.

  12. Effect of geomagnetic storms on VHF scintillations observed at low latitude

    Science.gov (United States)

    Singh, S. B.; Patel, Kalpana; Singh, A. K.

    2018-06-01

    A geomagnetic storm affects the dynamics and composition of the ionosphere and also offers an excellent opportunity to study the plasma dynamics. In the present study, we have used the VHF scintillations data recorded at low latitude Indian station Varanasi (Geomag. latitude = 14^{°}55^' }N, long. = 154^{°}E) which is radiated at 250 MHz from geostationary satellite UFO-02 during the period 2011-2012 to investigate the effects of geomagnetic storms on VHF scintillation. Various geomagnetic and solar indices such as Dst index, Kp index, IMF Bz and solar wind velocity (Vx) are used to describe the geomagnetic field variation observed during geomagnetic storm periods. These indices are very helpful to find out the proper investigation and possible interrelation between geomagnetic storms and observed VHF scintillation. The pre-midnight scintillation is sometimes observed when the main phase of geomagnetic storm corresponds to the pre-midnight period. It is observed that for geomagnetic storms for which the recovery phase starts post-midnight, the probability of occurrence of irregularities is enhanced during this time and extends to early morning hours.

  13. Simultaneous high- and low-latitude reconnection: ESR and DMSP observations

    Directory of Open Access Journals (Sweden)

    F. Pitout

    2002-09-01

    Full Text Available We present EISCAT Svalbard Radar and DMSP observations of a double cusp during an interval of predominantly northward IMF on 26 November 2000. In the cusp region, the ESR dish, pointing northward, recorded sun-ward ionospheric flow at high latitudes (above 82° GL, indicating reconnection occuring in the magnetospheric lobe. Meanwhile, the same dish also recorded bursts of poleward flow, indicative of bursty reconnection at the subsolar magnetopause. Within this time interval, the DMSP F13 satellite passed in the close vicinity of the Svalbard archipelago. The particle measurement on board exhibited a double cusp structure in which two oppositely oriented ion dispersions are recorded. We interpret this set of data in terms of simultaneous merging at low- and high-latitude magnetopause. We discuss the conditions for which such simultaneous high-latitude and low-latitude reconnection can be anticipated. We also discuss the consequences of the presence of two X-lines in the dayside polar ionosphere.Key words. Magnetospheric physics (solar wind-magnetosphere interactions – Ionosphere (polar ionosphere; plasma convection

  14. Whistler-triggered chorus emissions observed during daytime at low latitude ground station Jammu

    Science.gov (United States)

    Pratap Patel, Ravindra; Singh, K. K.; Singh, A. K.; Singh, R. P.

    In this paper, we present whistler-triggered chorus emission recorded during daytime at low latitude ground station Jammu (geomag. Lat. = 22 degree 26 minute N; L = 1.17) during the period from 1996 to 2003. After analysis of the eight years collected data, we found out 29 events, which are definitely identified as chorus emission triggered by whistlers. During the observation period the magnetic activity is high. Analysis shows that the whistlers have propagated along the geomagnetic field line having L-values lying between L = 1.9 and 4.4. These waves could have propagated along the geomagnetic field lines either in ducted mode or pro-longitudinal mode. The measured relative intensity of the triggered emission and whistler wave is approximately the same and also varies from one event to another. It is proposed that these waves are generated through a process of wave-particle interaction and wave-wave interactions. Related parameters of this interaction are computed for different L-value and wave amplitude. With the help of dynamic spectra of these emissions, the proposed mechanisms are explained.

  15. Time variations of oxygen emission lines and solar wind dynamic parameters in low latitude region

    Science.gov (United States)

    Jamlongkul, P.; Wannawichian, S.; Mkrtichian, D.; Sawangwit, U.; A-thano, N.

    2017-09-01

    Aurora phenomenon is an effect of collision between precipitating particles with gyromotion along Earth’s magnetic field and Earth’s ionospheric atoms or molecules. The particles’ precipitation occurs normally around polar regions. However, some auroral particles can reach lower latitude regions when they are highly energetic. A clear emission from Earth’s aurora is mostly from atomic oxygen. Moreover, the sun’s activities can influence the occurrence of the aurora as well. This work studies time variations of oxygen emission lines and solar wind parameters, simultaneously. The emission’s spectral lines were observed by Medium Resolution Echelle Spectrograph (MRES) along with 2.4 meters diameter telescope at Thai National Observatory, Intanon Mountain, Chiang Mai, Thailand. Oxygen (OI) emission lines were calibrated by Dech-Fits spectra processing program and Dech95 2D image processing program. The correlations between oxygen emission lines and solar wind dynamics will be analyzed. This result could be an evidence of the aurora in low latitude region.

  16. Ionospheric effects at low latitudes during the March 22, 1979, geomagnetic storm

    International Nuclear Information System (INIS)

    Fesen, C.G.; Crowley, G.; Roble, R.G.

    1989-01-01

    This paper investigates the response of the equatorial ionosphere to the neutral atmosphere perturbations produced by the magnetic storm of March 22, 1979. A numerical model of the equatorial ionosphere is used to calculate the maximum electron densities and F layer heights associated with a storm-perturbed neutral atmosphere and circulation model. Possible electric field perturbations due to the storm are ignored. The neutral atmosphere and dynamics are simulated by the National Center for Atmospheric Research thermospheric general circulation model (TGCM) for the storm day of March 22, 1979, and the preceding quiet day. The most striking feature of the TGCM storm day simulations is the presence of waves in the neutral composition, wind, and temperature fields which propagate from high latitudes to the equator. The TGCM-calculated fields for the two days are input into a low-latitude ionosphere model which calculates n max and h max between ±20 degree dip latitude. The calculated nighttime 6300-angstrom airglow emission and the altitude profiles of electron concentration are also highly perturbed by the storm. Examination of ionosonde data for March 22, 1979, shows remarkable agreement between the measured and predicted changes in f 0 F 2 and h max near 140 degree W. Poorer agreement near 70 degree W may be due to the neglect of electric field perturbations and the approximations inherent in the modeling. The results of these simulations indicate that the major factor influencing the storm time ionospheric behavior in this case is the neutral wind

  17. Performance of Emcore Third Generation CPV Modules in the Low Latitude Marine Environment of Hawaii

    Science.gov (United States)

    Hoffman, Richard; Buie, Damien; King, David; Glesne, Thomas

    2011-12-01

    Emcore third generation concentrating photovoltaic (CPV) modules were evaluated in the low latitude location of Kihei, Hawaii. For comparison, the best available monocrystalline silicon flat panel modules were included in both dual-axis tracked and fixed mount configurations. The daily DC uncorrected efficiency value for the CPV modules averaged over the six-month performance period was 25.9% compared to 16% to 17% for the flat panels. Higher daily energy was obtained from CPV modules than tracked flat panels when daily direct solar insolation was greater than 5 kWh/m2 and more than fixed mount flat panel when direct insolation was greater than 3 kWh/m2. The module energy conversion performance was demonstrated to be predictable using a parametric model developed by Sandia National Laboratory. Soiling accumulation on module entrance surface was surprisingly rapid in the local environment. Measured energy loss rate due to soiling were two to six times larger for CPV compared to flat panel losses.

  18. The structure of low-latitude Pc3 pulsations observed by CHAMP and on the ground

    Directory of Open Access Journals (Sweden)

    D. C. Ndiitwani

    2009-03-01

    Full Text Available The structure of low-latitude continuous pulsations termed Pc3, which are naturally occurring MHD waves in the Earth's magnetosphere, were studied by comparing ground and satellite magnetic field measurements. Data from two induction magnetometers, located at Hermanus and Sutherland in South Africa were used in conjunction with Challenging Minisatellite Payload (CHAMP satellite observations to study a Pc3 event observed on 15 February 2003, at a time when CHAMP was passing over the ground stations. We observed a number of discrete frequency oscillations for the fast mode wave, one of which drives a field line resonance (FLR at characteristic latitude as detected by both ground and satellite measurements. Consequently, our observations confirmed the compressional wave as being the driver of the field line resonance. The toroidal mode frequency observed on CHAMP experienced a Doppler frequency shift due to the rapid motion across the resonance region. Polarization hodograms in the resonance region clearly showed the expected 90° rotation of the field line resonant magnetic field components.

  19. The structure of low-latitude Pc3 pulsations observed by CHAMP and on the ground

    Directory of Open Access Journals (Sweden)

    D. C. Ndiitwani

    2009-03-01

    Full Text Available The structure of low-latitude continuous pulsations termed Pc3, which are naturally occurring MHD waves in the Earth's magnetosphere, were studied by comparing ground and satellite magnetic field measurements. Data from two induction magnetometers, located at Hermanus and Sutherland in South Africa were used in conjunction with Challenging Minisatellite Payload (CHAMP satellite observations to study a Pc3 event observed on 15 February 2003, at a time when CHAMP was passing over the ground stations. We observed a number of discrete frequency oscillations for the fast mode wave, one of which drives a field line resonance (FLR at characteristic latitude as detected by both ground and satellite measurements. Consequently, our observations confirmed the compressional wave as being the driver of the field line resonance. The toroidal mode frequency observed on CHAMP experienced a Doppler frequency shift due to the rapid motion across the resonance region. Polarization hodograms in the resonance region clearly showed the expected 90° rotation of the field line resonant magnetic field components.

  20. Climate fluctuations during the Holocene in NW Iberia: High and low latitude linkages

    Science.gov (United States)

    Pena, L. D.; Francés, G.; Diz, P.; Esparza, M.; Grimalt, J. O.; Nombela, M. A.; Alejo, I.

    2010-07-01

    High resolution benthic foraminiferal stable isotopes (δ 18O, δ 13C) and molecular biomarkers in the sediments are used here to infer rapid climatic changes for the last 8200 years in the Ría de Muros (NW Iberian Margin). Benthic foraminiferal δ 18O and δ 13C potentially register migrations in the position of the hydrographic front formed between two different intermediate water masses: Eastern North Atlantic Central Water of subpolar origin (ENACW sp) and subtropical origin (ENACW st). The molecular biomarkers in the sediment show a strong coupling between continental organic matter inputs and negative δ 13C values in benthic foraminifera. The rapid centennial and millennial events registered in these records have been compared with two well known North Atlantic Holocene records from the subtropical Atlantic sea surface temperatures (SST) anomalies off Cape Blanc, NW Africa and the subpolar Atlantic (Hematite Stained Grains percentage, subpolar North Atlantic). Comparison supports a strong link between high- and low-latitude climatic perturbations at centennial-millennial time scales during the Holocene. Spectral analyses also points to a pole-to-equator propagation of the so-called 1500 yr cycles. Our results demonstrate that during the Holocene, the NW Iberian Margin has undergone a series of rapid events which are likely triggered at high latitudes in the North Atlantic and are rapidly propagated towards lower latitudes. Conceivably, the propagation of these rapid climatic changes involves a shift in atmospheric and oceanic circulatory systems.

  1. Some unusual discrete VLF emissions observed at a low-latitude ground station at Agra

    Directory of Open Access Journals (Sweden)

    B. Singh

    Full Text Available A detailed analysis of the VLF emissions data obtained during occasional whistler campaigns at the low-latitude ground station Agra (geomagnetic latitude 17°1' N, L = 1.15 has yielded some unusual discrete VLF emissions of the rising type. These include (1 emissions occurring at time intervals increasing in ge ommetrical progression, (2 emissions occuring simulta neously in different frequency ranges and (3 emissions observed during daytime. In the present study, the observed characteristics of these emissions are described and interpreted. It is shown that the increasing time delay between different components of the emissions match closely with the propagation time delays between different hops of a whistler of dispersion 19 s1/2, the unusual occurrence of the emissions in two different frequency ranges approximately at the same time may possibly be linked with their generation at two different locations, and the occurrence of emissions during daytime may be due to propagation under the influence of equatorial anomaly.

  2. Some unusual discrete VLF emissions observed at a low-latitude ground station at Agra

    Directory of Open Access Journals (Sweden)

    B. Singh

    1997-08-01

    Full Text Available A detailed analysis of the VLF emissions data obtained during occasional whistler campaigns at the low-latitude ground station Agra (geomagnetic latitude 17°1' N, L = 1.15 has yielded some unusual discrete VLF emissions of the rising type. These include (1 emissions occurring at time intervals increasing in ge ommetrical progression, (2 emissions occuring simulta neously in different frequency ranges and (3 emissions observed during daytime. In the present study, the observed characteristics of these emissions are described and interpreted. It is shown that the increasing time delay between different components of the emissions match closely with the propagation time delays between different hops of a whistler of dispersion 19 s1/2, the unusual occurrence of the emissions in two different frequency ranges approximately at the same time may possibly be linked with their generation at two different locations, and the occurrence of emissions during daytime may be due to propagation under the influence of equatorial anomaly.

  3. Effect of magnetic activity on plasma bubbles over equatorial and low-latitude regions in East Asia

    Directory of Open Access Journals (Sweden)

    G. Li

    2009-01-01

    Full Text Available The dependence of plasma bubble occurrence in the eveningside ionosphere, with magnetic activity during the period years 2001–2004, is studied here based on the TEC observations gathered by ground-based GPS receivers which are located in the equatorial and low-latitude regions in East Asia. The observed plasma bubbles consist of the plasma-bubble events in the equatorial (stations GUAM, PIMO and KAYT, and low-latitude regions (stations WUHN, DAEJ and SHAO. It is shown that most equatorial plasma-bubble events commence at 20:00 LT, and may last for >60 min. The magnetic activity appears to suppress the generation of equatorial plasma bubbles with a time delay of more than 3 h (4–9 h. While in the low-latitude regions, most plasma-bubble events commence at about 23:00 LT and last for <45 min. The best correlation between Kp and low-latitude plasma-bubble occurrence is found with an 8–9 h delay, a weak correlation exists for time delays of 6–7 h. This probably indicates that over 3 h delayed disturbance dynamo electric fields obviously inhibit the development of plasma bubbles in the pre-midnight sector.

  4. Impact of high-latitude energy input on the mid- and low-latitude ionosphere and thermosphere

    Science.gov (United States)

    Lu, G.; Sheng, C.

    2017-12-01

    High-latitude energy input has a profound impact on the ionosphere and thermosphere especially during geomagnetic storms. Intense auroral particle precipitation ionizes neutral gases and modifies ionospheric conductivity; collisions between neutrals and fast-moving ions accelerate the neutral winds and produce Joule frictional heating; and the excess Joule and particle heating causes atmospheric upwelling and changes neutral composition due to the rising of the heavier, molecular-rich air. In addition, impulsive Joule heating launches large-scale gravity waves that propagate equatorward toward middle and low latitudes and even into the opposite hemisphere, altering the mean global circulation of the thermosphere. Furthermore, high-latitude electric field can also directly penetrate to lower latitudes under rapidly changing external conditions, causing prompt ionospheric variations in the mid- and low-latitude regions. To study the effects of high-latitude energy input, we apply the different convection and auroral precipitation patterns based on both empirical models and the AMIE outputs. We investigate how the mid- and low-latitude regions respond to the different specifications of high-latitude energy input. The main purpose of the study is to delineate the various dynamical, electrodynamical, and chemical processes and to determine their relative importance in the resulting ionospheric and thermospheric properties at mid and low latitudes.

  5. Solar and magnetospheric forcing of the low latitude thermospheric mass density as observed by CHAMP

    Directory of Open Access Journals (Sweden)

    S. Müller

    2009-05-01

    Full Text Available We have studied the dependence of the thermospheric mass density at equatorial latitudes on the influence of various drivers. This statistical study is based on CHAMP accelerometer measurements. Our aim is to delineate the influences of the different contributions. For the isolation of the effects we make use of a dedicated data selection procedure and/or removal of disturbing effects. In a first step all readings are normalised to an altitude of 400 km. For the investigation of the solar influences only magnetically quiet days (Ap≤15 are considered. The dependence on solar flux can well be described by a linear relation within the flux range F10.7=80–240. The slope is twice as steep on the day side as on the night side. The air density exhibits clear annual and semi-annual variations with maxima at the equinoxes and a pronounced minimum around June solstice. The thermosphere maintains during quiet days a day to night mass density ratio very close to 2, which is independent of solar flux level or season. The magnetospheric input causing thermospheric density enhancement can well be parameterised by the am activity index. The low latitude density responds with a delay to changes of the index by about 3 h on the dayside and 4–5 h on the night side. The magnetospheric forcing causes an additive contribution to the quiet-time density, which is linearly correlated with the am index. The slopes of density increases are the same on the day and night sides. We present quantitative expressions for all the dependences. Our results suggest that all the studied forcing terms can be treated as linear combinations of the respective contribution.

  6. Simultaneous VHF radar backscatter and ionosonde observations of low-latitude E region

    Directory of Open Access Journals (Sweden)

    A. K. Patra

    2005-03-01

    Full Text Available The first results of simultaneous observations made on the low-latitude field-aligned irregularities (FAI using the MST radar located at Gadanki (13.5° N, 79.2° E, dip 12.5° and the Es parameters using an ionosonde at a nearby station Sriharikota (13.7° N, 80.1° E, dip 12.6° are presented. The observations show that while the height of the most intense radar echoes is below the virtual height of Es (h'Es during daytime, it is found to be either below or above during nighttime. The strength of the FAI is better correlated with the top penetration frequency (ftEs and the blanketing frequency (fbEs during the night (r=0.4 in both cases as compared to the day (r=0.35 and -0.04, respectively. Furthermore, the signal strength of FAI is reasonably correlated with (ftEs-fbEs during daytime (r=0.59 while very poorly correlated during nighttime (r=0.18. While the radar observations in general appear to have characteristics close to that of mid-latitudes, the relationship of these with the Es parameters are poorer than that of mid-latitudes. The observations reported here, nevertheless, are quite consistent with the expectations based on the gradient drift instability mechanism.

  7. Evaluation of olive flowering at low latitude sites in Argentina using a chilling requirement model

    Energy Technology Data Exchange (ETDEWEB)

    Aybar, V.E.; Melo-Abreu, J.P. de; Searles, P.S.; Matias, A.G.; Del Rio, C.; Caballero, C. M.; Rousseaux, M.C.

    2015-07-01

    Olive production has expanded significantly from the Mediterranean Basin into the New World over the last two decades. In some cases, cultivars of European origin have been introduced at a large commercial scale with little previous evaluation of potential productivity. The objective of this study was to evaluate whether a temperature-driven simulation model developed in the Mediterranean Basin to predict normal flowering occurrence and flowering date using cultivar-specific thermal requirements was suitable for the low latitude areas of Northwest Argentina. The model was validated at eight sites over several years and a wide elevation range (350–1200 m above mean sea level) for three cultivars (‘Arbequina’, ‘Frantoio’, ‘Leccino’) with potentially different chilling requirements. In ‘Arbequina’, normal flowering was observed at almost all sites and in all years, while normal flowering events in ‘Frantoio’ and ‘Leccino’ were uncommon. The model successfully predicted if flowering would be normal in 92% and 83% of the cases in ‘Arbequina’ and ‘Frantoio’, respectively, but was somewhat less successful in ‘Leccino’ (61%). When flowering occurred, the predicted flowering date was within ± 7 days of the observed date in 71% of the cases. Overall, the model results indicate that cultivar-specific simulation models may be used as an approximate tool to predict whether individual cultivars will be successful in new growing areas. In Northwest Argentina, the model could be used to identify cultivars to replace ‘Frantoio’ and ‘Leccino’ and to simulate global warming scenarios. (Author)

  8. Self-consistent model of the low-latitude boundary layer

    International Nuclear Information System (INIS)

    Phan, T.D.; Sonnerup, B.U.Oe.; Lotko, W.

    1989-01-01

    A simple two-dimensional, steady state, viscous model of the dawnside and duskside low-latitude boundary layer (LLBL) has been developed. It incorporates coupling to the ionosphere via field-aligned currents and associated field-aligned potential drops, governed by a simple conductance law, and it describes boundary layer currents, magnetic fields, and plasma flow in a self-consistent manner. The magnetic field induced by these currents leads to two effects: (1) a diamagnetic depression of the magnetic field in the equatorial region and (2) bending of the field lines into parabolas in the xz plane with their vertices in the equatorial plane, at z = 0, and pointing in the flow direction, i.e., tailward. Both effects are strongest at the magnetopause edge of the boundary layer and vanish at the magnetospheric edge. The diamagnetic depression corresponds to an excess of plasma pressure in the equatorial boundary layer near the magnetopause. The boundary layer structure is governed by a fourth-order, nonlinear, ordinary differential equation in which one nondimensional parameter, the Hartmann number M, appears. A second parameter, introduced via the boundary conditions, is a nondimensional flow velocity v 0 * at the magnetopause. Numerical results from the model are presented and the possible use of observations to determine the model parameters is discussed. The main new contribution of the study is to provide a better description of the field and plasma configuration in the LLBL itself and to clarify in quantitative terms the circumstances in which induced magnetic fields become important

  9. Japan contribution to studies of low-latitude and equatorial ionosphere over Southeast Asia

    Science.gov (United States)

    Yamamoto, M.; Ishii, M.; Otsuka, Y.; Shiokawa, K.; Saito, A.; Tsuda, T.; Fukao, S.

    2008-12-01

    A dense observation network to study ionosphere is deployed over Southeast Asian countries of Indonesia, Thailand, and Vietnam. The Equatorial Atmosphere Radar (EAR) at Kototabang, Indonesia is the center facility, and supporting instruments, i.e., an ionosonde, a VHF ionosphere radar, an optical imager, a GPS scintillation receiver, a magnetometer, a meteor radar, etc. are collocated. NICT operates the ionosonde network SEALION (South East Asian Low-latitude IOnosonde Network) that meridionally extends from the EAR site to Chumphong and Chiang Mai in Thailand, and two more sites (Baq Liu and Phy Thuy) in Vietnam. Additional facilities are an MF radar at Pameungpeuk, Indonesia, and an optical imager at Darwin, Australia. We have been observing plasma bubbles since 2001, that, for example, contributed clarification of time- spatial structures of the phenomena, their relationship to the pre-reversal enhancement, control of bubble occurrence by the meridional winds, etc. We are starting studies of their seeding by means of atmospheric waves that propages from the lower atmosphere, too. In 2008, Nagoya University will soon install three Fabry-Perot interferometers at the EAR site, Chiang Mai, and Darwin. We also have a plan to install digital beacon receivers in some of these sites. Next research program that follows CPEA (Coupling Processes in the Equatorial Atmosphere, 2001-2007) is under planning now. Our main facilities cover ± 10° of geomagnetic latitude, where the magnetic declination is relatively small, and the geomagnetic equator is in the geographic northern hemisphere. We will review our achievements, and show on-going efforts and future plans. Collaboration with the C/NOFS satellite, and comparisons to results from the American sector should be beneficial for global-scale understanding of the equatorial ionosphere/atmosphere.

  10. Low-latitude boundary layer near noon: An open field line model

    Science.gov (United States)

    Lyons, L. R.; Schulz, M.; Pridmore-Brown, D. C.; Roeder, J. L.

    1994-01-01

    We propose that many features of the cusp and low-latitude boundary layer (LLBL) observed near noon MLT can be explained by interpreting the LLBL as being on open lines with an inner boundary at the separatrix between open and closed magnetic field lines. This interpretation places the poleward boundary of the LLBL and equatorward boundary of the cusp along the field line that bifurcates at the cusp neutral point. The interpretation accounts for the abrupt boundary of magnetosheath particles at the inner edge of the LLBL, a feature that is inconsistent with LLBL formation by diffusion onto closed field lines, and for the distribution of magnetosheath particles appearing more as one continuous region than as two distinct regions across the noon cusp/LLBL boundary. Furthermore, we can explain the existence of energetic radiation belt electrons and protons with differing pitch angle distributions within the LLBL and their abrupt cutoff at the poleward boundary of the LLBL. By modeling the LLBL and cusp region quantitatively, we can account for a hemispherical difference in the location of the equatorial boundary of the cusp that is observed to be dependent on the dipole tilt angle but not on the interplanetary magnetic field (IMF) x component. We also find important variations and hemispherical differences in that the size of the LLBL that should depend strongly upon the x component of the IMF. This prediction is observationally testable. Finally, we find that when the IMF is strongly northward, the LLBL may include a narrow region adjacent to the magnetopause where field lines are detached (i.e., have both ends connected to the IMF).

  11. Estimation of Mesospheric Densities at Low Latitudes Using the Kunming Meteor Radar Together With SABER Temperatures

    Science.gov (United States)

    Yi, Wen; Xue, Xianghui; Reid, Iain M.; Younger, Joel P.; Chen, Jinsong; Chen, Tingdi; Li, Na

    2018-04-01

    Neutral mesospheric densities at a low latitude have been derived during April 2011 to December 2014 using data from the Kunming meteor radar in China (25.6°N, 103.8°E). The daily mean density at 90 km was estimated using the ambipolar diffusion coefficients from the meteor radar and temperatures from the Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) instrument. The seasonal variations of the meteor radar-derived density are consistent with the density from the Mass Spectrometer and Incoherent Scatter (MSIS) model, show a dominant annual variation, with a maximum during winter, and a minimum during summer. A simple linear model was used to separate the effects of atmospheric density and the meteor velocity on the meteor radar peak detection height. We find that a 1 km/s difference in the vertical meteor velocity yields a change of approximately 0.42 km in peak height. The strong correlation between the meteor radar density and the velocity-corrected peak height indicates that the meteor radar density estimates accurately reflect changes in neutral atmospheric density and that meteor peak detection heights, when adjusted for meteoroid velocity, can serve as a convenient tool for measuring density variations around the mesopause. A comparison of the ambipolar diffusion coefficient and peak height observed simultaneously by two co-located meteor radars indicates that the relative errors of the daily mean ambipolar diffusion coefficient and peak height should be less than 5% and 6%, respectively, and that the absolute error of the peak height is less than 0.2 km.

  12. Statistical evaluation of GLONASS amplitude scintillation over low latitudes in the Brazilian territory

    Science.gov (United States)

    de Oliveira Moraes, Alison; Muella, Marcio T. A. H.; de Paula, Eurico R.; de Oliveira, César B. A.; Terra, William P.; Perrella, Waldecir J.; Meibach-Rosa, Pâmela R. P.

    2018-04-01

    The ionospheric scintillation, generated by the ionospheric plasma irregularities, affects the radio signals that pass through it. Their effects are widely studied in the literature with two different approaches. The first one deals with the use of radio signals to study and understand the morphology of this phenomenon, while the second one seeks to understand and model how much this phenomenon interferes in the radio signals and consequently in the services to which these systems work. The interest of several areas, particularly to those that are life critical, has increased using the concept of satellite multi-constellation, which consists of receiving, processing and using data from different navigation and positioning systems. Although there is a vast literature analyzing the effects of ionospheric scintillation on satellite navigation systems, the number of studies using signals received from the Russian satellite positioning system (named GLONASS) is still very rare. This work presents for the first time in the Brazilian low-latitude sector a statistical analysis of ionospheric scintillation data for all levels of magnetic activities obtained by a set of scintillation monitors that receive signals from the GLONASS system. In this study, data collected from four stations were used in the analysis; Fortaleza, Presidente Prudente, São José dos Campos and Porto Alegre. The GLONASS L-band signals were analyzed for the period from December 21, 2012 to June 20, 2016, which includes the peak of the solar cycle 24 that occurred in 2014. The main characteristics of scintillation presented in this study include: (1) the statistical evaluation of seasonal and solar activity, showing the chances that an user on similar geophysical conditions may be susceptible to the effects of ionospheric scintillation; (2) a temporal analysis based on the local time distribution of scintillation at different seasons and intensity levels; and (3) the evaluation of number of

  13. PRODUCTION OF DISSOLVING GRADE PULP FROM ALFA

    Directory of Open Access Journals (Sweden)

    Baya Bouiri

    2010-02-01

    Full Text Available Alfa, also known as Stipa tenacissimaI or “halfa”, is grown in North Africa and south Spain. Due to its short fiber length, paper made from alfa pulp retains bulk and takes block letters well. In this study alfa was evaluated for bleached pulp production. Two cellulose pulps with different chemical compositions were pulped by a conventional kraft process. One sample was taken from the original alfa material and another from alfa that had been pretreated by diluted acid. The pulp produced from the pretreated alfa was bleached by the elemental-chlorine-free sequences DEPD and DEDP. The yield, Kappa number, brightness, and α- cellulose content of bleached and unbleached pulps were evaluated. The results showed that during the chemical pulping process, treated alfa cooked more easily than the original alfa. The treated alfa pulp also showed very good bleaching, reaching a brightness level of 94.8% ISO with a yield of 93.6% at an α-cellulose content 96.8(% with a DEDP bleaching sequence, compared to 83.2% ISO brightness level, 92.8% yield, and 95.1% α-cellulose content for bleached pulp with a DEPD bleaching sequence. Therefore, this alfa material could be considered as a worthwhile choice for cellulosic fiber supply.

  14. A cusp catastrophe model of mid-long-term landslide evolution over low latitude highlands of China

    Science.gov (United States)

    Tao, Yun; Cao, Jie; Hu, Jinming; Dai, Zhicheng

    2013-04-01

    Based on a model describing a certain landslide case and catastrophe theory, we derived a cusp catastrophe model and corresponding inversion method to study mid-long-term landslide evolution. According to data of landslides, precipitation, and socioeconomic development from 1976 to 2008, the cusp catastrophe model describing this landslide evolution across a low-latitude highland area in China is obtained with the least squares method. Results of the model indicate that human activity determines landslide intensity. Local precipitation also impacts yearly landslide intensity to some extent, and controls the time when a strong and abrupt change in landslides occurs. During the period 1976-2008, there was an abrupt decrease of landslide intensity during 1994-1995, and an abrupt increase during 1995-1996. Since then, there have been frequent landslides in the low-latitude highland, with greater intensity. All these factors provide a scientific basis for formulating a contingency plan regarding landslide disasters.

  15. CONSTRAINING THE DISTRIBUTION OF DARK MATTER IN THE INNER GALAXY WITH AN INDIRECT DETECTION SIGNAL: THE CASE OF A TENTATIVE 130 GeV γ-RAY LINE

    International Nuclear Information System (INIS)

    Yang Ruizhi; Feng Lei; Li Xiang; Fan Yizhong

    2013-01-01

    Dark matter distribution in the very inner region of our Galaxy is still debated. In N-body simulations, a cuspy dark matter halo density profile is favored. Several dissipative baryonic processes, however, are found to be able to significantly flatten dark matter distribution, and a cored dark matter halo density profile is possible. Baryons dominate the gravitational potential in the inner Galaxy, hence a direct constraint on the abundance of dark matter particles is rather challenging. Recently, a few groups have identified a tentative 130 GeV line signal in the Galactic center, which could be interpreted as the signal of dark matter annihilation. Using current 130 GeV line data and adopting the generalized Navarro-Frenk-White profile of the dark matter halo—local dark matter density ρ 0 = 0.4 GeV cm –3 and r s = 20 kpc—we obtain a 95% confidence level lower (upper) limit on the inner slope of dark matter density distribution, α = 1.06 (the cross section of dark matter annihilation into γ-rays (σv) χχ →γ γ = 1.3 × 10 –27 cm 3 s –1 ). Such a slope is consistent with the results of some N-body simulations and, if the signal is due to dark matter, suggests that baryonic processes may be unimportant.

  16. Potential impacts of wintertime soil moisture anomalies from agricultural irrigation at low latitudes on regional and global climates

    Science.gov (United States)

    Wey, Hao-Wei; Lo, Min-Hui; Lee, Shih-Yu; Yu, Jin-Yi; Hsu, Huang-Hsiung

    2015-10-01

    Anthropogenic water management can change surface energy budgets and the water cycle. In this study, we focused on impacts of Asian low-latitude irrigation on regional and global climates during boreal wintertime. A state-of-the-art Earth system model is used to simulate the land-air interaction processes affected by irrigation and the consequent responses in atmospheric circulation. Perturbed experiments show that wet soil moisture anomalies at low latitudes can reduce the surface temperature on a continental scale through atmospheric feedback. The intensity of prevailing monsoon circulation becomes stronger because of larger land-sea thermal contrast. Furthermore, anomalous upper level convergence over South Asia and midlatitude climatic changes indicate tropical-extratropical teleconnections. The wintertime Aleutian low is deepened and an anomalous warm surface temperature is found in North America. Previous studies have noted this warming but left it unexplained, and we provide plausible mechanisms for these remote impacts coming from the irrigation over Asian low-latitude regions.

  17. Herschel HIFI GOT C+ Survey: CII, HI, and CO Emissions in a Sample of Transition Clouds and Star-Forming regions in the Inner Galaxy

    Science.gov (United States)

    Pineda, Jorge; Velusamy, Thangasamy; Langer, William D.; Goldsmith, Paul; Li, Di; Yorke, Harold

    The GOT C+ a HIFI Herschel Key Project, studies the diffuse ISM throughout the Galactic Plane, using C+ as cloud tracer. The C+ line at 1.9 THz traces a so-far poorly studied stage in ISM cloud evolution -the transitional clouds going from atomic HI to molecular H2. This transition cloud phase, which is difficult to observe in HI and CO alone, may be best characterized via CII emission or absorption. The C+ line is also an excellent tracer of the warm diffuse gas and the warm, dense gas in the Photon Dominated Regions (PDRs). We can, therefore, use the CII emission as a probe to understand the effects of star formation on their interstellar environment. We present our first results on the transition between dense and hot gas (traced by CII) and dense and cold gas (traced by 12CO and 13CO) along a few representative lines of sight in the inner Galaxy from longitude 325 degrees to 25 degrees, taken during the HIFI Priority Science Phase. Comparisons of the high spectral resolution ( 1 km/s) HIFI data on C+ with HI, 12CO, and 13CO spectra allow us to separate out the different ISM components along each line of sight. Our results provide detailed information about the transition of diffuse atomic to molecular gas clouds needed to understand star formation and the lifecycle of the interstellar gas. These observations are being carried out with the Herschel Space Observatory, which is an ESA cornerstone mission, with contributions from NASA. This research was conducted at the Jet Propulsion Laboratory, California Institute of Technology under contract with the National Aeronautics and Space Administration. JLP was supported under the NASA Postdoctoral Program at JPL, Caltech, administered by Oak Ridge Associated Universities through a contract with NASA, and is currently supported as a Caltech-JPL Postdoctoral associate.

  18. Large enhancements in low latitude total electron content during 15 May 2005 geomagnetic storm in Indian zone

    Directory of Open Access Journals (Sweden)

    N. Dashora

    2009-05-01

    Full Text Available Results pertaining to the response of the equatorial and low latitude ionosphere to a major geomagnetic storm that occurred on 15 May 2005 are presented. These results are also the first from the Indian zone in terms of (i GPS derived total electron content (TEC variations following the storm (ii Local low latitude electrodynamics response to penetration of high latitude convection electric field (iii effect of storm induced traveling atmospheric disturbances (TAD's on GPS-TEC in equatorial ionization anomaly (EIA zone. Data set comprising of ionospheric TEC obtained from GPS measurements, ionograms from an EIA zone station, New Delhi (Geog. Lat. 28.42° N, Geog. Long. 77.21° E, ground based magnetometers in equatorial and low latitude stations and solar wind data obtained from Advanced Composition Explorer (ACE has been used in the present study. GPS receivers located at Udaipur (Geog. Lat. 24.73° N, Geog. Long. 73.73° E and Hyderabad (Geog. Lat. 17.33° N, Geog. Long. 78.47° E have been used for wider spatial coverage in the Indian zone. Storm induced features in vertical TEC (VTEC have been obtained comparing them with the mean VTEC of quiet days. Variations in solar wind parameters, as obtained from ACE and in the SYM-H index, indicate that the storm commenced on 15 May 2005 at 02:39 UT. The main phase of the storm commenced at 06:00 UT on 15 May with a sudden southward turning of the Z-component of interplanetary magnetic field (IMF-Bz and subsequent decrease in SYM-H index. The dawn-to-dusk convection electric field of high latitude origin penetrated to low and equatorial latitudes simultaneously as corroborated by the magnetometer data from the Indian zone. Subsequent northward turning of the IMF-Bz, and the penetration of the dusk-to-dawn electric field over the dip equator is also discernible. Response of the low latitude ionosphere to this storm may be characterized in terms of (i enhanced background level of VTEC as compared to

  19. Large enhancements in low latitude total electron content during 15 May 2005 geomagnetic storm in Indian zone

    Directory of Open Access Journals (Sweden)

    N. Dashora

    2009-05-01

    Full Text Available Results pertaining to the response of the equatorial and low latitude ionosphere to a major geomagnetic storm that occurred on 15 May 2005 are presented. These results are also the first from the Indian zone in terms of (i GPS derived total electron content (TEC variations following the storm (ii Local low latitude electrodynamics response to penetration of high latitude convection electric field (iii effect of storm induced traveling atmospheric disturbances (TAD's on GPS-TEC in equatorial ionization anomaly (EIA zone.

    Data set comprising of ionospheric TEC obtained from GPS measurements, ionograms from an EIA zone station, New Delhi (Geog. Lat. 28.42° N, Geog. Long. 77.21° E, ground based magnetometers in equatorial and low latitude stations and solar wind data obtained from Advanced Composition Explorer (ACE has been used in the present study. GPS receivers located at Udaipur (Geog. Lat. 24.73° N, Geog. Long. 73.73° E and Hyderabad (Geog. Lat. 17.33° N, Geog. Long. 78.47° E have been used for wider spatial coverage in the Indian zone. Storm induced features in vertical TEC (VTEC have been obtained comparing them with the mean VTEC of quiet days. Variations in solar wind parameters, as obtained from ACE and in the SYM-H index, indicate that the storm commenced on 15 May 2005 at 02:39 UT. The main phase of the storm commenced at 06:00 UT on 15 May with a sudden southward turning of the Z-component of interplanetary magnetic field (IMF-Bz and subsequent decrease in SYM-H index. The dawn-to-dusk convection electric field of high latitude origin penetrated to low and equatorial latitudes simultaneously as corroborated by the magnetometer data from the Indian zone. Subsequent northward turning of the IMF-Bz, and the penetration of the dusk-to-dawn electric field over the dip equator is also discernible. Response of the low latitude ionosphere to this storm may be characterized in terms of (i

  20. Case study on total electron content enhancements at low latitudes during low geomagnetic activities before the storms

    Directory of Open Access Journals (Sweden)

    Libo Liu

    2008-05-01

    Full Text Available Sometimes the ionospheric total electron content (TEC is significantly enhanced during low geomagnetic activities before storms. In this article, we investigate the characteristics of those interesting TEC enhancements using regional and global TEC data. We analyzed the low-latitude TEC enhancement events that occurred around longitude 120° E on 10 February 2004, 21 January 2004, and 4 March 2001, respectively. The TEC data are derived from regional Global Positioning System (GPS observations in the Asia/Australia sector as well as global ionospheric maps (GIMs produced by Jet Propulsion Laboratory (JPL. Strong enhancements under low geomagnetic activity before the storms are simultaneously presented at low latitudes in the Asia/Australia sector in regional TEC and JPL GIMs. These TEC enhancements are shown to be regional events with longitudinal and latitudinal extent. The regions of TEC enhancements during these events are confined at narrow longitude ranges around longitude 120° E. The latitudinal belts of maxima of enhancements locate around the northern and southern equatorial ionization anomaly (EIA crests, which are consistent with those low-latitude events presented by Liu et al. (2008. During the 4 March 2001 event, the total plasma density Ni observed by the Defense Meteorological Satellite Program (DMSP spacecraft F13 at 840 km altitude are of considerably higher values on 4 March than on the previous day in the TEC enhanced regions. Some TEC enhancement events are possibly due to contributions from auroral/magnetospheric origins; while there are also quasi-periodic enhancement events not related to geomagnetic activity and associated probably with planetary wave type oscillations (e.g. the 6 January 1998 event. Further investigation is warrented to identify/separate contributions from possible sources.

  1. The low-latitude boundary layer at mid-altitiudes: Relation to large-scale Birkeland currents

    International Nuclear Information System (INIS)

    Woch, J.; Yamauchi, M.; Lundin, R.; Potemra, T.A.; Zanetti, L.J.

    1993-01-01

    In this work the authors seek to test a projected relationship between the low latitude boundary layer (LLBL) and field aligned currents (FAC), or Birkeland currents. They use the procedure developed by Woch and Lundin for identifying LLBL boundaries. They look for correlations between properties of the FAC and properties of the LLBL. Their results show that in most cases the FAC observed are totally inside the region which exhibits LLBL plasma precipitation. The authors argue that within the biases to their data because of its source, and relative sensitivities, their conclusions support earlier work which argues for the LLBL acting as a source region for FAC features

  2. Analysis of strong ionospheric scintillation events measured by means of GPS signals at low latitudes during disturbed conditions

    Science.gov (United States)

    Forte, B.

    2012-08-01

    Drifting structures characterized by inhomogeneities in the spatial electron density distribution at ionospheric heights cause the scintillation of radio waves propagating through. The fractional electron density fluctuations and the corresponding scintillation levels may reach extreme values at low latitudes during high solar activity. Different levels of scintillation were observed on experimental data collected in the Asian sector at low latitudes by means of a GPS dual frequency receiver under moderate solar activity (2005). The GPS receiver used in these campaigns was particularly modified in firmware in order to record power estimates on the C/A code as well as on the carriers L1 and L2. Strong scintillation activity was recorded in the post-sunset period (saturatingS4 and SI as high as 20 dB). Spectral modifications and broadening was observed during high levels of scintillation possibly indicating refractive scattering taking place instead of diffractive scattering. A possible interpretation of those events was attempted on the basis of the refractive scattering theory developed by Uscinski (1968) and Booker and MajidiAhi (1981).

  3. ULF fluctuations of the geomagnetic field and ionospheric sounding measurements at low latitudes during the first CAWSES campaign

    Directory of Open Access Journals (Sweden)

    U. Villante

    2006-07-01

    Full Text Available We present an analysis of ULF geomagnetic field fluctuations at low latitudes during the first CAWSES campaign (29 March-3 April 2004. During the whole campaign, mainly in the prenoon sector, a moderate Pc3-4 pulsation activity is observed, clearly related to interplanetary upstream waves. On 3 April, in correspondence to the Earth's arrival of a coronal mass ejection, two SIs are observed whose waveforms are indicative of a contribution of the high-latitude ionospheric currents to the low-latitude ground field. During the following geomagnetic storm, low frequency (Pc5 waves are observed at discrete frequencies. Their correspondence with the same frequencies detected in the radial components of the interplanetary magnetic field and solar wind speed suggests that Alfvénic solar wind fluctuations may act as direct drivers of magnetospheric fluctuations. A cross-phase analysis, using different pairs of stations, is also presented for identifying field line resonant frequencies and monitoring changes in plasmaspheric mass density. Lastly, an analysis of ionospheric vertical soundings, measured at the Rome ionosonde station (41.8° N, 12.5° E, and vertical TEC measurements deduced from GPS signals within an European network shows the relation between the ULF resonances in the inner magnetosphere and thermal plasma density variations during geomagnetically quiet conditions, in contrast to various storm phases at the end of the CAWSES campaign.

  4. Simultaneous in-situ observations of the signatures of dayside reconnection at the high- and low-latitude magnetopause

    Directory of Open Access Journals (Sweden)

    J. A. Wild

    2005-02-01

    Full Text Available We present magnetic field and particle data recorded by the Cluster and Geotail satellites in the vicinity of the high- and low-latitude dayside magnetopause, respectively, on 17 February 2003. A favourable conjunction of these spacecraft culminated in the observation of a series of flux transfer events (FTEs, characterised by bipolar perturbations in the component of the magnetic field normal to the magnetopause, an enhancement in the overall magnetic field strength, and field tilting effects in the plane of the magnetopause whilst the satellites were located on the magnetosheath side of the boundary. Whilst a subset of the FTE signatures observed could be identified as being either normal or reverse polarity, the rapid succession of events observed made it difficult to classify some of the signatures unambiguously. Nevertheless, by considering the source region and motion of flux tubes opened by magnetic reconnection at low latitudes (i.e. between Cluster and Geotail, we demonstrate that the observations are consistent with the motion of northward (southward and tailward moving flux tubes anchored in the Northern (Southern Hemisphere passing in close proximity to the Cluster (Geotail satellites. We are able to demonstrate that a multi-spacecraft approach, coupled with a realistic model of flux tube motion in the magnetosheath, enables us to infer the approximate position of the reconnection site, which in this case was located at near-equatorial latitudes.

  5. The variations of oxygen emissions in corresponding to Earth's aurora in low latitude region under influence of solar wind dynamics

    Science.gov (United States)

    Jamlongkul, P.; Wannawichian, S.

    2017-12-01

    Earth's aurora in low latitude region was studied via time variations of oxygen emission spectra, simultaneously with solar wind data. The behavior of spectrum intensity, in corresponding with solar wind condition, could be a trace of aurora in low latitude region including some effects of high energetic auroral particles. Oxygen emission spectral lines were observed by Medium Resolution Echelle Spectrograph (MRES) at 2.4-m diameter telescope at Thai National Observatory, Inthanon Mountain, Chiang Mai, Thailand, during 1-5 LT on 5 and 6 February 2017. The observed spectral lines were calibrated via Dech95 - 2D image processing program and Dech-Fits spectra processing program for spectrum image processing and spectrum wavelength calibration, respectively. The variations of observed intensities each day were compared with solar wind parameters, which are magnitude of IMF (|BIMF|) including IMF in RTN coordinate (BR, BT, BN), ion density (ρ), plasma flow pressure (P), and speed (v). The correlation coefficients between oxygen spectral emissions and different solar wind parameters were found to vary in both positive and negative behaviors.

  6. Common origin of positive ionospheric storms at middle latitudes and the geomagnetic activity effect at low latitudes

    International Nuclear Information System (INIS)

    Proelss, G.W.

    1993-01-01

    The author looks for a correlation between two different atmospheric effects. They are a positive atmospheric storm (an anomalous increase in the F2 region ionization density), observed at middle latitudes, and the geomagnetic activity effect (the anomalous changes of temperature and gas density seen in the thermosphere), observed at low latitudes. A temporal correlation is sought to test the argument that both of these effects are the result of travelling atmospheric disturbances (TAD). A TAD is a pulselike atmospheric wave thought to be generated by substorm activity, and to propagate with high velocity (600 m/s) from polar latitudes toward equatorial latitudes. The author looks at data from five separate events correlating magnetic, ionospheric, and neutral atmospheric measurements. The conclusion is that there is a positive correlation between magnetic substorm activity at high latitudes, and positive ionospheric storms at middle latitudes and geomagnetic activity at low latitudes. The time correlations are consistent with high propagation speeds between these events. The author also presents arguments which indicate that the middle latitude positive ionospheric storms are not the result of electric field effects

  7. Oman's low latitude "Snowball Earth" pole revisited: Late Cretaceous remagnetisation of Late Neoproterozoic carbonates in Northern Oman

    Science.gov (United States)

    Rowan, C. J.; Tait, J.

    2010-12-01

    Glaciogenic diamictites and associated ‘cap’ carbonates within the Neoproterozoic Huqf Supergroup of Oman record a period of extreme, possibly global, glaciations between 750-635 Ma (the "Snowball Earth"). We have performed high-resolution paleomagnetic sampling of two sections through ~635 Ma cap carbonates in the Jebel Akhdar region of northern Oman. Stepwise thermal demagnetisation reveals a low temperature component carried by goethite, and a high temperature component carried by haematite, that are both aligned with the modern dipole field direction. Occasional reversed polarity directions antipodal to the present day field indicate pervasive weathering of these outcrops over timescales of at least 1 Ma. Between these two overprints an intermediate component with typical unblocking temperatures of 300-550 C, probably carried by magnetite, can also be isolated in most samples. A robust fold test clearly demonstrates that this component was acquired after Paleozoic folding of the carbonates, and was most likely acquired during exhumation associated with emplacement of the Semail ophiolite during the Late Cretaceous (95-68 Ma). In geographic co-ordinates, the intermediate component has an almost horizontal NNW or SSE direction, similar to directions previously reported from outcrops of the ophiolite close to the Jebel Akhdar region, and from thermally altered basement rocks in the the Saih Hatat window further to the east [Feinberg et al. 1999]. Hints of an older, Permian, remagnetisation of the carbonates, which is also observed in the Saih Hatat basement rocks, have also produced a false polarity stratigraphy in one of the sampled sections. Our results contrast with the previously reported low latitude pole from the Huqf Supergroup [Kilner et al., 2005], which was considered to be amongst the more reliable paleomagnetic data supporting glaciations extending to low latitudes during the late Neoproterozoic. However, this interpretation was made on the basis

  8. A Model for the Sounding Rocket Measurement on an Ionospheric E-F Valley at the Hainan Low Latitude Station

    International Nuclear Information System (INIS)

    Wang Zheng; Shi Jiankui; Guan Yibing; Liu Chao; Zhu Guangwu; Torkar Klaus; Fredrich Martin

    2014-01-01

    To understand the physics of an ionospheric E-F valley, a new overlapping three-Chapman-layer model is developed to interpret the sounding rocket measurement in the morning (sunrise) on May 7, 2011 at the Hainan low latitude ionospheric observation station (19.5°N, 109.1°E). From our model, the valley width, depth and height are 43.0 km, 62.9% and 121.0 km, respectively. From the sounding rocket observation, the valley width, depth and height are 42.2 km, 47.0% and 123.5 km, respectively. The model results are well consistent with the sounding rocket observation. The observed E-F valley at Hainan station is very wide and deep, and rapid development of the photochemical process in the ionosphere should be the underlying reason. (astrophysics and space plasma)

  9. Low frequency geomagnetic field fluctuations at low latitude during the passage of a higher pressure solar wind region

    Directory of Open Access Journals (Sweden)

    U. Villante

    1997-06-01

    Full Text Available The passage of a higher pressure solar wind region at the Earth's orbit marked the onset of low latitude (L=1.6 fluctuations in the frequency range (0.8–5.5 mHz for both the horizontal geomagnetic field components. Spectral peaks mostly occur at the same frequencies as the spectral enhancements which appeared in the long term analysis of experimental measurements from the same station and were tentatively interpreted in terms of ground signatures of global magnetospheric modes. A comparison with simultaneous observations discussed by previous investigations allows us to conclude that the same set of frequencies is enhanced in a wide portion of the Earth's magnetosphere.

  10. The storm-time ring current: a statistical analysis at two widely separated low-latitude stations

    Directory of Open Access Journals (Sweden)

    P. Francia

    2004-11-01

    Full Text Available We conducted a statistical analysis of the geomagnetic field variations during the storm main phase at two low-latitude stations, separated by several hours in magnetic local time, in order to investigate the asymmetry and longitudinal extent of the storm-time ring current. The results show evidence for an asymmetric current which typically extends from evening to noon and, during moderate solar wind electric field conditions, up to the early morning, confirming the important role of the magnetospheric convection in the ring current energization. We also analyzed a possible relationship between the local current intensity during the storm main phase and the substorm activity observed at different time delays τ with respect to the storm onset. The results show a significant anticorrelation for τ =-1h, indicating that if the substorm activity is high just before the storm, a weaker ring current develops.

  11. Ionospheric E–F valley observed by a sounding rocket at the low-latitude station Hainan

    Directory of Open Access Journals (Sweden)

    J. K. Shi

    2013-08-01

    Full Text Available According to the sounding rocket experiment conducted at Hainan ionospheric observatory (19.5° N, 109.1° E, a valley between the E layer and F layer in the ionospheric electron density profile is observed and presented. The sounding rocket was launched in the morning (06:15 LT on 7 May 2011, and the observed electron density profile outside the valley agrees with the simultaneous observation by the DPS-4 digisonde at the same station. The width of the observed valley was about 42 km, the depth almost 50%, and the altitude of the electron density minimum 123.5 km. This is the first observation of the E–F valley in the low-latitude region in the East Asian sector. The results are also compared with models, and the physical mechanism of the observed valley is discussed in this paper.

  12. Equinoctial spread-F occurrence at low latitudes in different longitude sectors under moderate and high solar activity

    Science.gov (United States)

    Pietrella, M.; Pezzopane, M.; Fagundes, P. R.; de Jesus, R.; Supnithi, P.; Klinngam, S.; Ezquer, R. G.; Cabrera, M. A.

    2017-11-01

    A comparative study aimed to investigate the equatorial and low-latitude spread-F occurrences for moderate solar activity (MSA) and high solar activity (HSA), was carried out considering concurrent observations made in some ionospheric stations, which identify three separate longitudinal sectors: Chiang Mai (CGM; 18.8° N, 98.9° E, mag. Lat. 13.2° N) and Chumphon (CPN; 10.7° N, 99.4° E, mag. Lat. 3.2° N), Thailand; Palmas (PAL; 10.2° S, 311.8° E, mag. Lat. 0.9° S) and São José dos Campos (SJC; 23.2° S, 314.1° E, mag. Lat. 14.0° S), Brazil; Tucumán (TUC; 26.9° S, 294.6° E, mag. Lat. 16.8° S), Argentina. Spread-F phenomena recorded during the equinoctial months of September and October 2010, March and April 2011, for MSA, March and April 2014, September and October 2014, for HSA, were classified in two different modes: range spread-F (RSF) and frequency spread-F (FSF). The satellite trace (ST) occurrence was also investigated as possible precursor of spread-F events. When comparing the results of equatorial (CPN and PAL) and low-latitude (CGM, SJC, and TUC) stations, some common features independently of the solar activity emerge: (1) a prevalence of RSF signatures is observed in the time interval 20:00-03:00 LT, while FSF occurrences prevail in the time interval 03:00-06:00 LT; (2) STs are confirmed to be a possible precursor of RSF occurrences. For HSA, at equatorial latitudes, spread-F occurrences in the Thai sector (CPN) are higher than those observed in the Brazilian sector (PAL). When comparing the results of low-latitude stations of CGM, SJC, and TUC some unusual aspects characterizing the morphology of spread-F occurrences emerge: (1) contrary to the Thai and Argentine sectors, in the Brazilian sector (SJC), RSF and FSF appearances in September, for HSA, are observed with relatively long persistence times between about 03:00-06:00 LT and 01:00-03:00 LT respectively, while balanced RSF and FSF occurrences with short persistence times are

  13. The low-latitude boundary layer at mid-altitudes: Identification based on viking hot plasma data

    International Nuclear Information System (INIS)

    Woch, J.; Lundin, R.

    1993-01-01

    The authors address the problem of studying the magnetospheric low latitude boundary layer (LLBL). A limited number of in situ measurements are available, but for extensive study it will be necessary to learn how this region maps into the polar ionosphere so that extended ground based observations will become possible. They look at Viking passes through the auroral oval, and interpret the ion spectra recorded in terms of precipitating ions. The characteristic ion signatures then allow identification of source regions for these ions, and subsequent projections of these regions earthward. They feel they have found ion signatures of the LLBL in areas predicted by previous work, and that correlations with solar wind density provides support for the magnetosheath origin of these ions

  14. SuperDARN HOP radars observation of ionospheric convection associated with low-latitude aurora observed at Hokkaido, Japan

    Science.gov (United States)

    Nishitani, N.; Hori, T.; Kataoka, R.; Ebihara, Y.; Shiokawa, K.; Otsuka, Y.; Suzuki, H.; Yoshikawa, A.

    2016-12-01

    The SuperDARN HOkkaido Pair of (HOP) radars, consisting of the Hokkaido East (2006-) and West (2014-) radars, are the SuperDARN radars located at the lowest geomagnetic latitude (36.5 degrees), and have been continuously measuring ionospheric convection at high to subauroral and middle latitudes with high temporal resolutions (Japan from 15 to 19 UT on March 17, 2015 and from 1900 to 2030 UT on December 20, 2015, identified using optical instruments such as all-sky CCD camera, wide field of view digital camera and meridian scanning photometer. Both events occurred during the main phase of the relatively large geomagnetic storms with minimum Dst of -223 nT and -170 nT respectively. The ionospheric convection at mid-latitude regions associated with the low-latitude auroral emission is characterized by (1) transient equatorward flows up to about 500 m/s in the initial phase of the emission (the geomagnetic field data at Paratunka, Far East Russia show corresponding negative excursions), and (2) sheared flow structure consisting of westward flow (about 500 m/s) equatorward of eastward flow (1000 m/s), with the equatorward boundary of auroral emission embedded in the westward flow region which expanded up to below 50 deg geomagnetic latitude. These observations imply that the electric field / convection distribution plays important roles in continuously generating the low latitude auroral emission. In particular the observation of the equatorward flow (dawn-dusk electric field) up to as low as about 50 deg geomagnetic latitude is the direct evidence for the presence of electric field to drive ring current particles into the plasmaspheric regions.

  15. "Alfa" i "Võmpel" bez maski / Andrei Sharov

    Index Scriptorium Estoniae

    Sharov, Andrei

    2004-01-01

    Venemaa FSB keskuse, mille koosseisu kuuluvad ka eriüksused Alfa ja Võmpel, töötajad osalevad terroristide neutraliseerimise ja pantvangide vabastamise erioperatsioonides. Intervjuu keskuse staabi uue juhiga

  16. Strategicheskiy analiz predpriyatiya ZAO Alfa Motor Grupp

    OpenAIRE

    Antonova, Maria

    2016-01-01

    The subject of the bachelor work is the company ZAO Alfa Motor Group. The aim is to conduct strategic analysis of economic activity, evaluation of the effectiveness of current policies and develop recommendations and proposals to change the company's development strategy. ZAO Alfa Motor Group - a network of specialized service centers and car sales of spare parts, specialized in cars of Toyota and Lexus. Bachelor work has two main parts. In the first part of the work to uncover the meaning of...

  17. Determining the Current and Future Health of Low-Latitude Andean Glaciers Using an Equilibrium Line Altitude Model and Hypsometric Data from the Randolph Glacier Inventory

    Science.gov (United States)

    Malone, A.; MacAyeal, D. R.

    2015-12-01

    Mountain glaciers have been described as the water towers of world, and for many populations in the low-latitude South American Andes, glacial runoff is vital for agricultural, industrial, and basic water needs. Previous studies of low-latitude Andean glaciers suggest a precarious future due to contemporary warming. These studies have looked at trends in freezing level heights or observations of contemporary retreat. However, regional-scale understanding of low-latitude glacial responses to present and future climate change is limited, in part due to incomplete information about the extent and elevation distribution of low-latitude glaciers. The recently published Randolph Glacier Inventory (RGI) (5.0) provides the necessary information about the size and elevation distribution of low-latitude glaciers to begin such studies. We determine the contemporary equilibrium line altitudes (ELAs) for low-latitude Andean glaciers in the RGI, using a numerical energy balance ablation model driven with reanalysis and gridded data products. Contemporary ELAs tend to fall around the peak of the elevation histogram, with an exception being the southern-most outer tropical glaciers whose modeled ELAs tend to be higher than the elevation histogram for that region (see below figure). Also, we use the linear tends in temperature and precipitation from the contemporary climatology to extrapolate 21stcentury climate forcings. Modeled ELAs by the middle on the century are universally predicted to rise, with outer tropical ELAs rising more than the inner tropical glaciers. These trends continue through the end of the century. Finally, we explore how climate variables and parameters in our numerical model may vary for different warming scenarios from United Nation's IPCC AR5 report. We quantify the impacts of these changes on ELAs for various climate change trajectories. These results support previous work on the precarious future of low latitude Andean glaciers, while providing a richer

  18. Low frequency modulation of transionospheric radio wave amplitude at low-latitudes: possible role of field line oscillations

    Directory of Open Access Journals (Sweden)

    A. K. Sinha

    Full Text Available Ionospheric scintillations of radio waves at low-latitudes are associated with electron density irregularities. These irregularities are field-aligned and can provide excitation energy all along the field line to non-local field-aligned oscillations, such as the local field line oscillations. Eigen-periods of toroidal field line oscillations at low-latitudes, computed by using the dipole magnetic field and ion distributions obtained from the International Reference Ionosphere (IRI for typical nighttime conditions, fall in the range of 20–25 s. When subjected to spectral analysis, signal strength of the radio waves recorded on the 250 MHz beacon at Pondicherry (4.5° N dip, Mumbai (13.4° N dip and Ujjain (18.6° N dip exhibit periodicities in the same range. For the single event for which simultaneous ground magnetic data were available, the geomagnetic field also oscillated at the same periodicity. The systematic presence of a significant peak in the 20–25 s range during periods of strong radio wave scintillations, and its absence otherwise suggests the possibility that field line oscillations are endogenously excited by the irregularities, and the oscillations associated with the excited field line generate the modulation characteristics of the radio waves received on the ground. The frequency of modulation is found to be much lower than the characteristic frequencies that define the main body of scintillations, and they probably correspond to scales that are much larger than the typical Fresnel scale. It is possible that the refractive mechanism associated with larger scale long-lived irregularities could be responsible for the observed phenomenon. Results of a preliminary numerical experiment that uses a sinusoidal phase irregularity in the ionosphere as a refracting media are presented. The results show that phase variations which are large enough to produce a focal plane close to the ground can reproduce features that are not

  19. Low frequency modulation of transionospheric radio wave amplitude at low-latitudes: possible role of field line oscillations

    Directory of Open Access Journals (Sweden)

    A. K. Sinha

    2002-01-01

    Full Text Available Ionospheric scintillations of radio waves at low-latitudes are associated with electron density irregularities. These irregularities are field-aligned and can provide excitation energy all along the field line to non-local field-aligned oscillations, such as the local field line oscillations. Eigen-periods of toroidal field line oscillations at low-latitudes, computed by using the dipole magnetic field and ion distributions obtained from the International Reference Ionosphere (IRI for typical nighttime conditions, fall in the range of 20–25 s. When subjected to spectral analysis, signal strength of the radio waves recorded on the 250 MHz beacon at Pondicherry (4.5° N dip, Mumbai (13.4° N dip and Ujjain (18.6° N dip exhibit periodicities in the same range. For the single event for which simultaneous ground magnetic data were available, the geomagnetic field also oscillated at the same periodicity. The systematic presence of a significant peak in the 20–25 s range during periods of strong radio wave scintillations, and its absence otherwise suggests the possibility that field line oscillations are endogenously excited by the irregularities, and the oscillations associated with the excited field line generate the modulation characteristics of the radio waves received on the ground. The frequency of modulation is found to be much lower than the characteristic frequencies that define the main body of scintillations, and they probably correspond to scales that are much larger than the typical Fresnel scale. It is possible that the refractive mechanism associated with larger scale long-lived irregularities could be responsible for the observed phenomenon. Results of a preliminary numerical experiment that uses a sinusoidal phase irregularity in the ionosphere as a refracting media are presented. The results show that phase variations which are large enough to produce a focal plane close to the ground can reproduce features that are not

  20. Administration of follitropin alfa and lutropin alfa combined in a single injection: a feasibility assessment

    Directory of Open Access Journals (Sweden)

    Agostinetto Rita

    2009-05-01

    Full Text Available Abstract Background Gonadotrophins are routinely administered in assisted reproductive technology (ART treatment protocols. Recombinant human follicle-stimulating hormone (r-hFSH; follitropin alfa and recombinant human luteinizing hormone (r-hLH; lutropin alfa can be administered individually or in a fixed combination. The ability to vary the FSH to LH dose ratio in a single injection without compromising the bioactivity of either gonadotrophin or generating losses of active principle is important for physicians and patients alike. Methods This study investigated whether follitropin alfa (GONAL-f (R, as lyophilized powder for reconstitution or solution from the GONAL-f (R (filled-by-mass [FbM] Prefilled Pen, could be used to reconstitute Pergoveris TM (follitropin alfa/lutropin alfa 150 IU/75 IU lyophilized powder. In Ratio Groups 1 and 2, the r-hFSH:r-hLH ratio was 3:1; in Ratio Groups 3 and 4, the ratios of r-hFSH:r-hLH were 5:1 and 8:1, respectively. The protein content and bioactivity of each mixed solution were evaluated. The r-hFSH and r-hLH content was determined using reverse-phase high performance liquid chromatography. The biological activity of r-hFSH and r-hLH was assessed using the Steelman-Pohley and Van Hell in vivo bioassays in rats, respectively. Results Follitropin alfa/lutropin alfa 150 IU/75 IU lyophilized powder could be successfully mixed with follitropin alfa 75 IU FbM solution that was either reconstituted from lyophilized powder or injected directly from the prefilled pen to create solutions with ratios of r-hFSH and r-hLH from 3:1 to 8:1. The measured content of r-hFSH and r-hLH corresponded favourably with the target protein content in Ratio Groups 1–4. The in vivo target and measured bioactivity of r-hFSH and r-hLH were also closely matched in all Ratio Groups. Conclusion Follitropin alfa lyophilized powder or solution can be accurately mixed with follitropin alfa/lutropin alfa 150 IU/75 IU lyophilized powder to

  1. Implementation of Trigger Tiles for ALFA Simulation

    CERN Document Server

    Rehaag, Thomas Joseph

    2017-01-01

    The Absolute Luminosity For ATLAS (ALFA) experiment was designed to accurately measure the luminosity of the intersecting proton beams at the ATLAS interaction point [1]. However, the ALFA experiment has shifted its primary purpose from luminosity measurement to elastic and inelastic proton collisions. This change was the result of difficulty in fitting parameters in the region governed by Coulomb scattering. The operational principle for luminosity measurement with ALFA relied on detecting elastic proton collisions, so the detector is suited to its role in proton collision measurements. The ALFA detector consists of several sensitive components, including the main detector (MD), overlap detectors (ODs) and trigger tiles. A diagram of the ALFA detector is shown in Figure 1. The main detector is composed of layers of 0.5 × 0.5 mm2 cross section scintillating fibres with an active area of 0.48 × 0.48 mm2, which are directed diagonally across the detector with 64 fibres in each layer. The 20 total layers ar...

  2. Ionospheric scintillations on 3.925 GHz signal from Intelsat (701) at low latitude in the South Pacific region

    International Nuclear Information System (INIS)

    Kumar, S; Kishore, A; Ramachandran, V

    2007-01-01

    The morphological features of initial ionospheric scintillations on 3.925 GHz beacon signal from geostationary satellite Intelsat (701) at Suva (Lat., 18.08 0 S, Long., 178.3 0 E, Geom. Lat., 22.1 0 S), Fiji, a low latitude station in the South Pacific region have been studied during the period of December 2003 to June 2004. Scintillations were, in general, sparse, of which activity was more pronounced in the daytime. Scintillation occurrence was less in general, showing a peak value of about 2.5% at 09 h LT and a secondary peak of about 2% at around 16 h LT. Scintillations were weak (S 4 index ≤ 0.25) and occurred mostly in patches of short duration of 2-5 min. It is reported here that weak and short duration scintillations with more daytime occurrence are mainly due to (i) the higher frequency beacon signal used (ii) the recording station being situated off the equatorial ionisation anomaly belt, and (iii) the period of observation falling in the low solar activity phase of the current solar cycle

  3. Effect of equatorial electrodynamics on low-latitude thermosphere as inferred from neutral optical dayglow emission observations

    Science.gov (United States)

    Karan, D. K.; Duggirala, P. R.

    2017-12-01

    The diurnal variations in daytime airglow emission intensity measurements at three wavelengths OI 777.4 nm, OI 630.0 nm, and OI 557.7 nm made from a low-latitude location, Hyderabad (Geographic 17.50 N, 78.40 E; 8.90 N Mag. Lat) in India have been investigated. The intensity patterns showed both symmetric and asymmetric behavior in their respective diurnal emission variability with respect to local noon. The asymmetric diurnal behavior is not expected considering the photochemical nature of the production mechanisms. The reason for this observed asymmetric diurnal behavior has been found to be predominantly the temporal variation in the equatorial electrodynamics. The plasma that is transported across latitudes due to the action of varying electric field strength over the magnetic equator in the daytime contributes to the asymmetric diurnal behavior in the neutral daytime airglow emissions. Independent magnetic and radio measurements support this finding. It is also noted that this asymmetric diurnal behavior in the neutral emission intensities has a solar cycle dependence with more number of days during high solar activity period showing asymmetric diurnal behavior compared to those during low-solar activity epoch. These intensity variations over long time scale demonstrate that the daytime neutral optical emissions are extremely sensitive to the changes in the eastward electric field over low- and equatorial-latitudes.

  4. Short- and Long-Timescale Thermospheric Variability as Observed from OI 630.0 nm Dayglow Emissions from Low Latitudes

    Science.gov (United States)

    Pallamraju, Duggirala; Das, Uma; Chakrabarti, Supriya

    2011-01-01

    We carried out high-cadence (5 min) and high-spatial resolution (2deg magnetic latitude) observations of daytime OI 630.0 nm airglow emission brightness from a low-latitude station to understand the behavior of neutral dynamics in the daytime. The results indicate that the wave periodicities of 12.20 min, and 2 h exist over a wide spatial range of around 8deg-12deg magnetic latitudes. The 20.80 min periodicities in the dayglow seem to appear more often in the measurements closer to the magnetic equator and not at latitudes farther away. Further, periodicities in that range are found to be frequent in the variations of the equatorial electrojet (EEJ) strength as well. We show that wave periodicities due to the neutral dynamics, at least until around 8deg magnetic latitude, are influenced by those that affect the EEJ strength variation as well. Furthermore, the average daily OI 630.0 nm emission brightness over 3 months varied in consonance with that of the sunspot numbers indicating a strong solar influence on the magnitudes of dayglow emissions.

  5. Interferon alfa with or without ribavirin for chronic hepatitis C

    DEFF Research Database (Denmark)

    Kjaergard, L L; Krogsgaard, K; Gluud, C

    2001-01-01

    To assess the efficacy and safety of interferon alfa with or without ribavirin for treatment of chronic hepatitis C.......To assess the efficacy and safety of interferon alfa with or without ribavirin for treatment of chronic hepatitis C....

  6. OPPORTUNITIES OF DORNASE ALFA IN PEDIATRICS

    Directory of Open Access Journals (Sweden)

    O.I. Simonova

    2011-01-01

    Full Text Available Early treatment with Pulmozyme (dornase alfa and its prolonged use in combination with basis therapy results in decrease of exacerbation rate, prolongation of remission of bronchopulmonary process with normal ventilation functions of lungs and gives patients with cystic fibrosis an opportunity to live an active life. The drug is effective as a conservative treatment of chronic sinusitis polyposis; it’s frequent complication of cystic fibrosis. Dornase alfa has 3 clinical effects: strong mucolytic, anti-inflammatory and antibacterial effect. That is the reason for the treatment of other chronic bronchopulmonary diseases with this drug. Efficacy of dornase alpha depends on rough maintenance of the terms of drug use.Key words: children, dornase alfa, cystic fibrosis, chronic bronchopulmonary diseases, chronic rhinosinusitis, nasal polyposis, nebulizer therapy.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2011; 10 (4: 145–152

  7. Geomagnetic storm effects on the occurrences of ionospheric irregularities over the African equatorial/low-latitude region

    Science.gov (United States)

    Amaechi, P. O.; Oyeyemi, E. O.; Akala, A. O.

    2018-04-01

    The study investigated the effects of intense geomagnetic storms of 2015 on the occurrences of large scale ionospheric irregularities over the African equatorial/low-latitude region. Four major/intense geomagnetic storms of 2015 were analyzed for this study. These storms occurred on 17th March 2015 (-229 nT), 22nd June 2015 (-204 nT), 7th October 2015 (-124 nT), and 20th December 2015 (-170 nT). Total Electron Content (TEC) data obtained from five African Global Navigation Satellite Systems (GNSS) stations, grouped into eastern and western sectors were used to derive the ionospheric irregularities proxy indices, e.g., rate of change of TEC (ROT), ROT index (ROTI) and ROTI daily average (ROTIAVE). These indices were characterized alongside with the disturbance storm time (Dst), the Y component of the Interplanetary Electric Field (IEFy), polar cap (PC) index and the H component of the Earth's magnetic field from ground-based magnetometers. Irregularities manifested in the form of fluctuations in TEC. Prompt penetration of electric field (PPEF) and disturbance dynamo electric field (DDEF) modulated the behaviour of irregularities during the main and recovery phases of the geomagnetic storms. The effect of electric field over both sectors depends on the local time of southward turning of IMF Bz. Consequently, westward electric field inhibited irregularities during the main phase of March and October 2015 geomagnetic storms, while for the June 2015 storm, eastward electric field triggered weak irregularities over the eastern sector. The effect of electric field on irregularities during December 2015 storm was insignificant. During the recovery phase of the storms, westward DDEF suppressed irregularities.

  8. An extended study of the low-latitude boundary layer on the dawn and dusk flanks of the magnetosphere

    International Nuclear Information System (INIS)

    Mitchell, D.G.; Kutchko, F.; Williams, D.J.; Eastman, T.E.; Frank, L.A.; Russell, C.T.

    1987-01-01

    The authors present a study of the low-latitude boundary layer (LLBL) using ISEE 1 energetic particle, plasma, and magnetic field data obtained during numerous traversals of the LLBL that occurred on 66 ISEE 1 passes through the magnetospheric flank LLBL region. They use energetic particle distributions to determine dawn and dusk LLBL behavior and topology for varying orientations of the magnetosheath and/or interplanetary magnetic field (M/IMF), for different local times, and for changing levels of geomagnetic activity (Kp). This study corroborates and extends the earlier work of Williams et al. (1985) who presented a detailed study of two (dusk and dawn) ISEE 1 passes through the LLBL region for the case of northward M/IMF. They find that the dawn and dusk LLBL are on closed geomagnetic field lines for northward M/IMF but are on a combination of closed and open field lines for a southward M/IMF. The energetic particle distributions show that cases of reverse-draped field lines in the LLBL are consistent with an open field line topology. In addition, they find that the LLBL is thicker (thinner) for northward (southward) M/IMF and becomes thicker with increasing distance from the subsolar point. LLBL electric fields nominally are in the few (3-5) millivolts per meter range and display an apparent maximum value of ∼10mV/m. These electric fields capture magnetospherically drifting particles as they approach the LLBL and propel them tailward. In this way, the plasma sheet is the dominant source of energetic (approx-gt 10 keV) particles in the LLBL while the magnetosheath appears to be the dominant source for lower-energy (approx-lt 10 keV) LLBL particles

  9. Performance evaluation of ionospheric time delay forecasting models using GPS observations at a low-latitude station

    Science.gov (United States)

    Sivavaraprasad, G.; Venkata Ratnam, D.

    2017-07-01

    Ionospheric delay is one of the major atmospheric effects on the performance of satellite-based radio navigation systems. It limits the accuracy and availability of Global Positioning System (GPS) measurements, related to critical societal and safety applications. The temporal and spatial gradients of ionospheric total electron content (TEC) are driven by several unknown priori geophysical conditions and solar-terrestrial phenomena. Thereby, the prediction of ionospheric delay is challenging especially over Indian sub-continent. Therefore, an appropriate short/long-term ionospheric delay forecasting model is necessary. Hence, the intent of this paper is to forecast ionospheric delays by considering day to day, monthly and seasonal ionospheric TEC variations. GPS-TEC data (January 2013-December 2013) is extracted from a multi frequency GPS receiver established at K L University, Vaddeswaram, Guntur station (geographic: 16.37°N, 80.37°E; geomagnetic: 7.44°N, 153.75°E), India. An evaluation, in terms of forecasting capabilities, of three ionospheric time delay models - an Auto Regressive Moving Average (ARMA) model, Auto Regressive Integrated Moving Average (ARIMA) model, and a Holt-Winter's model is presented. The performances of these models are evaluated through error measurement analysis during both geomagnetic quiet and disturbed days. It is found that, ARMA model is effectively forecasting the ionospheric delay with an accuracy of 82-94%, which is 10% more superior to ARIMA and Holt-Winter's models. Moreover, the modeled VTEC derived from International Reference Ionosphere, IRI (IRI-2012) model and new global TEC model, Neustrelitz TEC Model (NTCM-GL) have compared with forecasted VTEC values of ARMA, ARIMA and Holt-Winter's models during geomagnetic quiet days. The forecast results are indicating that ARMA model would be useful to set up an early warning system for ionospheric disturbances at low latitude regions.

  10. Geomagnetically conjugate observations of ionospheric and thermospheric variations accompanied by a midnight brightness wave at low latitudes

    Science.gov (United States)

    Fukushima, D.; Shiokawa, K.; Otsuka, Y.; Kubota, M.; Yokoyama, T.; Nishioka, M.; Komonjinda, S.; Yatini, C. Y.

    2017-08-01

    We conducted geomagnetically conjugate observations of 630-nm airglow for a midnight brightness wave (MBW) at Kototabang, Indonesia [geomagnetic latitude (MLAT): 10.0°S], and Chiang Mai, Thailand (MLAT: 8.9°N), which are geomagnetically conjugate points at low latitudes. An airglow enhancement that was considered to be an MBW was observed in OI (630-nm) airglow images at Kototabang around local midnight from 2240 to 2430 LT on February 7, 2011. This MBW propagated south-southwestward, which is geomagnetically poleward, at a velocity of 290 m/s. However, a similar wave was not observed in the 630-nm airglow images at Chiang Mai. This is the first evidence of an MBW that does not have geomagnetic conjugacy, which also implies generation of MBW only in one side of the hemisphere from the equator. We simultaneously observed thermospheric neutral winds observed by a co-located Fabry-Perot interferometer at Kototabang. The observed meridional winds turned from northward (geomagnetically equatorward) to southward (geomagnetically poleward) just before the wave was observed. This indicates that the observed MBW was generated by the poleward winds which push ionospheric plasma down along geomagnetic field lines, thereby increasing the 630-nm airglow intensity. The bottomside ionospheric heights observed by ionosondes rapidly decreased at Kototabang and slightly increased at Chiang Mai. We suggest that the polarization electric field inside the observed MBW is projected to the northern hemisphere, causing the small height increase observed at Chiang Mai. This implies that electromagnetic coupling between hemispheres can occur even though the original disturbance is caused purely by the neutral wind.[Figure not available: see fulltext.

  11. Investigation of low-latitude hydrogen emission in terms of a two-component interstellar gas model

    International Nuclear Information System (INIS)

    Baker, P.L.; Burton, W.B.

    1975-01-01

    The high-resolution 21-cm hydrogen line observations at low galactic latitude of Burton and Verschuur have been analyzed to determine the large-scale distribution of galactic hydrogen. The distribution parameters are found by model fitting. Optical depth affects have been computed using a two-component gas model. Analysis shows that a multiphase description of the medium is essential to the interpretation of low-latitude emission observations. Where possible, the number of free parameters in the gas model has been reduced. Calculations were performed for a one-component, uniform spin temperature, gas model in order to show the systematic departures between this model and the data caused by the incorrect treatment of the optical depth effect. In the two-component gas, radiative transfer is treated by a Monte Carlo calculation since the opacity of the gas arises in a randomly distributed, cold, optically thick, low velocity-dispersion, cloud medium. The emission arises in both the cloud medium and a smoothly distributed, optically thin, high velocity-dispersion, intercloud medium. The synthetic profiles computed from the two-component model reproduce both the large-scale trends of the observed emission profiles and the magnitude of the small-scale emission irregularities. The analysis permits the determination of values for []he thickness of the galactic disk between half density points, the total observed neutral hydrogen mass of the Galaxy, and the central number density of the intercloud atoms. In addition, the analysis is sensitive to the size of clouds contributing to the observations. Computations also show that synthetic emission profiles based on the two-component model display both the zero-velocity and high-velocity ridges, indicative of optical thinness on a large scale, in spite of the presence of optically thick gas

  12. Performance evaluation of linear time-series ionospheric Total Electron Content model over low latitude Indian GPS stations

    Science.gov (United States)

    Dabbakuti, J. R. K. Kumar; Venkata Ratnam, D.

    2017-10-01

    Precise modeling of the ionospheric Total Electron Content (TEC) is a critical aspect of Positioning, Navigation, and Timing (PNT) services intended for the Global Navigation Satellite Systems (GNSS) applications as well as Earth Observation System (EOS), satellite communication, and space weather forecasting applications. In this paper, linear time series modeling has been carried out on ionospheric TEC at two different locations at Koneru Lakshmaiah University (KLU), Guntur (geographic 16.44° N, 80.62° E; geomagnetic 7.55° N) and Bangalore (geographic 12.97° N, 77.59° E; geomagnetic 4.53° N) at the northern low-latitude region, for the year 2013 in the 24th solar cycle. The impact of the solar and geomagnetic activity on periodic oscillations of TEC has been investigated. Results confirm that the correlation coefficient of the estimated TEC from the linear model TEC and the observed GPS-TEC is around 93%. Solar activity is the key component that influences ionospheric daily averaged TEC while periodic component reveals the seasonal dependency of TEC. Furthermore, it is observed that the influence of geomagnetic activity component on TEC is different at both the latitudes. The accuracy of the model has been assessed by comparing the International Reference Ionosphere (IRI) 2012 model TEC and TEC measurements. Moreover, the absence of winter anomaly is remarkable, as determined by the Root Mean Square Error (RMSE) between the linear model TEC and GPS-TEC. On the contrary, the IRI2012 model TEC evidently failed to predict the absence of winter anomaly in the Equatorial Ionization Anomaly (EIA) crest region. The outcome of this work will be useful for improving the ionospheric now-casting models under various geophysical conditions.

  13. ALFA: an automated line fitting algorithm

    Science.gov (United States)

    Wesson, R.

    2016-03-01

    I present the automated line fitting algorithm, ALFA, a new code which can fit emission line spectra of arbitrary wavelength coverage and resolution, fully automatically. In contrast to traditional emission line fitting methods which require the identification of spectral features suspected to be emission lines, ALFA instead uses a list of lines which are expected to be present to construct a synthetic spectrum. The parameters used to construct the synthetic spectrum are optimized by means of a genetic algorithm. Uncertainties are estimated using the noise structure of the residuals. An emission line spectrum containing several hundred lines can be fitted in a few seconds using a single processor of a typical contemporary desktop or laptop PC. I show that the results are in excellent agreement with those measured manually for a number of spectra. Where discrepancies exist, the manually measured fluxes are found to be less accurate than those returned by ALFA. Together with the code NEAT, ALFA provides a powerful way to rapidly extract physical information from observations, an increasingly vital function in the era of highly multiplexed spectroscopy. The two codes can deliver a reliable and comprehensive analysis of very large data sets in a few hours with little or no user interaction.

  14. Interferon alfa and ribavirin induced hair changes

    International Nuclear Information System (INIS)

    Amir, S.; Taj, A.; Muhamud, T.H.; Iqbal, Z.; Yaqub, F.

    2007-01-01

    Combination therapy of Interferon alfa and ribavirin in chronic hepatitis C has well documented cutaneous adverse effects. Most interesting of these has been reported on hair physiology. This study was conducted to determine the frequency and pattern of adverse effects involving hair in patients receiving combination of interferon alfa 2a and ribavirin for chronic hepatitis C. The study was conducted in Department of Dermatology, Division of Medicine Shaikh Zayed Hospital. Thirty Eight patients who completed treatment with interferon alfa (3 MIU subcutaneously thrice weekly) and 1200 mg ribavirin daily for 24 weeks were enrolled in this single-center study. The patient's response and examination finding particularly regarding involvement of hair was noted on a Proforma. Thirty Two out of thirty eight (84%) patients noted adverse effects involving hair. The most frequent was diffuse hair loss and occurred in 27 patients (71%). Hypertrichosis of eyelashes (trichomegaly) and eyebrows (synophyrs) was observed in 18 (47%) and 16 (42%) patients respectively. Graying of hair was noted in 4 patients (11%), while discoloration of moustache hair was seen in 2 patients (5%). Epilation at the site of subcutaneous injection was noted in 10 patients (26%). Alopecia areata was reported in 2 patients (5%). It is concluded that adverse effects involving hair are frequent and varied (hair loss to excess hair growth) during combination therapy with Interferon alfa-2a and Ribavirin for chronic hepatitis C. (author)

  15. Climatology of ionospheric scintillation over the Vietnam low-latitude region for the period 2006-2014

    Science.gov (United States)

    Tran, Thi Lan; Le, Huy Minh; Amory-Mazaudier, C.; Fleury, R.

    2017-10-01

    This paper presents the characteristics of the occurrence of ionospheric scintillations at low-latitude, over Vietnam, by using continuous data of three GSV4004 receivers located at PHUT/Hanoï (105.9°E, 21.0°N; magnetic latitude 14.4°N), HUES/Hue (107.6°E, 16.5°N; magnetic latitude 9.5°N) and HOCM/Ho Chi Minh city (106.6°E, 10.8°N; magnetic latitude 3.3°N) for the period 2006-2014. The results show that the scintillation activity is maximum during equinox months for all the years and depends on solar activity as expected. The correlations between the monthly percentage scintillation occurrence and the F10.7 flux are of 0.40, 0.52 and 0.67 for PHUT, HUES and HOCM respectively. The distribution of scintillation occurrences is dominant in the pre-midnight sector and around the northern crest of the equatorial ionization anomaly (EIA), from the 15°N to 20°N geographic latitude with a maximum at 16°N. The results obtained from the directional analysis show higher distributions of scintillations in the southern sky of PHUT and in the northern sky of HUES and HOCM, and in the elevation angles smaller than 40°. The correlation between ROTI and S4 is low and rather good at PHUT (under EIA) than HOCM (near equator). We found better correlation in the post-midnight hours and less correlation in the pre-midnight hours for all stations. When all satellites are considered during the period of 2009-2011, the range of variation of the ration between ROTI and S4 is from 1 to 7 for PHUT, from 0.3 to 6 for HUES and from 0.7 to 6 for HOCM.

  16. The INTERBALL-Tail ELECTRON experiment: initial results on the low-latitude boundary layer of the dawn magnetosphere

    Directory of Open Access Journals (Sweden)

    J.-A. Sauvaud

    Full Text Available The Toulouse electron spectrometer flown on the Russian project INTERBALL-Tail performs electron measurements from 10 to 26 000 eV over a 4 solid angle in a satellite rotation period. The INTERBALL-Tail probe was launched on 3 August 1995 together with a subsatellite into a 65° inclination orbit with an apogee of about 30 RE. The INTERBALL mission also includes a polar spacecraft launched in August 1996 for correlated studies of the outer magnetosphere and of the auroral regions. We present new observations concerning the low-latitude boundary layers (LLBL of the magnetosphere obtained near the dawn magnetic meridian. LLBL are encountered at the interface between two plasma regimes, the magnetosheath and the dayside extension of the plasma sheet. Unexpectedly, the radial extent of the region where LLBL electrons can be sporadically detected as plasma clouds can reach up to 5 RE inside the magnetopause. The LLBL core electrons have an average energy of the order of 100 eV and are systematically field-aligned and counterstreaming. As a trend, the temperature of the LLBL electrons increases with decreasing distance to Earth. Along the satellite orbit, the apparent time of occurrence of LLBL electrons can vary from about 5 to 20 min from one pass to another. An initial first comparison between electron- and magnetic-field measurements indicates that the LLBL clouds coincide with a strong increase in the magnetic field (by up to a factor of 2. The resulting strong magnetic field gradient can explain why the plasma-sheet electron flux in the keV range is strongly depressed in LLBL occurrence regions (up to a factor of sim10. We also show that LLBL electron encounters are related to field-aligned current structures and that wide LLBL correspond to northward interplanetary magnetic field. Evidence for LLBL/plasma-sheet electron leakage into the magnetosheath during southward IMF is also presented.

  17. Impact of Sudden Stratospheric Warming of 2009 on the Equatorial and Low-Latitude Ionosphere of the Indian Longitudes: A Case Study

    Science.gov (United States)

    Yadav, Sneha; Pant, Tarun K.; Choudhary, R. K.; Vineeth, C.; Sunda, Surendra; Kumar, K. K.; Shreedevi, P. R.; Mukherjee, S.

    2017-10-01

    Using the equatorial electrojet (EEJ)-induced surface magnetic field and total electron content (TEC) measurements, we investigated the impact of the sudden stratospheric warming (SSW) of January 2009 on the equatorial electrodynamics and low-latitude ionosphere over the Indian longitudes. Results indicate that the intensity of EEJ and the TEC over low latitudes (extending up to 30°N) exhibit significant perturbations during and after the SSW peak. One of the interesting features is the deviation of EEJ and TEC from the normal quiet time behavior well before the onset of the SSW. This is found to coincide with the beginning of enhanced planetary wave (PW) activity over high latitudes. The substantial amplification of the semidiurnal perturbation after the SSW peak is seen to be coinciding with the onset of new and full moons. The response of TEC to SSW is found to be latitude dependent as the near-equatorial (NE) stations show the semidiurnal perturbation only after the SSW peak. Another notable feature is the presence of reduced ionization in the night sector over the NE and low-latitude regions, appearing as an "ionization hole," well after the SSW peak. The investigation revealed the existence of a quasi 16 day wave in the TEC over low latitudes similar to the one present in the EEJ strength. These results have been discussed in the light of changes in the dynamical background because of enhanced PW activity during SSW, which creates favorable conditions for the amplification of lunar tides, and their subsequent interaction with the lower thermospheric tidal fields.

  18. Functionality and performance of the ALFA_CTPIN module

    CERN Document Server

    Iwanski, Wieslaw; Korcyl, Krzysztof; Oechsle, Jan

    2017-01-01

    The ALFA_CTPIN module has been designed in response to increased internal processing time of the Central Trigger Processor (CTP) of the ATLAS experiment which resulted in reducing time left to the ALFA detector to deliver its own triggers to the CTP within specified latency. Accelerated extraction of ALFA triggers from encoded signals and the possibility to perform local triggers processing by this module allowed ALFA to contribute to global triggering of the ATLAS detector. A huge number of implemented scalers and flexibility in defining triggers processing criteria make also from this module a very attractive tool for in-depth analysis of properties of the LHC beam.

  19. A 60-year record of 129I in Taal Lake sediments (Philippines): Influence of human nuclear activities at low latitude regions.

    Science.gov (United States)

    Zhang, Luyuan; Hou, Xiaolin; Li, Hong-Chun; Xu, Xiaomei

    2018-02-01

    The influence of human nuclear activities on environmental radioactivity is not well known at low latitude regions that are distant from nuclear test sites and nuclear facilities. A sediment core collected from Taal Lake in the central Philippines was analyzed for 129 I and 127 I to investigate this influence in a low-latitude terrestrial system. A baseline of 129 I/ 127 I atomic ratios was established at (2.04-5.14) × 10 -12 in the pre-nuclear era in this region. Controlled by the northeasterly equatorial trade winds, increased 129 I/ 127 I ratios of (20.1-69.3) × 10 -12 suggest that atmospheric nuclear weapons tests at the Pacific Proving Grounds in the central Pacific Ocean was the major source of 129 I in the sediment during 1956-1962. The 129 I/ 127 I ratios, up to 157.5 × 10 -12 after 1964, indicate a strong influence by European nuclear fuel reprocessing plants. The East Asian Winter Monsoon is found to be the dominant driving force in the atmospheric dispersion of radioactive iodine ( 129 I) from the European nuclear fuel reprocessing plants to Southeast Asia, which is also important for dispersion of other airborne pollutants from the middle-high to low latitude regions. A significant 129 I/ 127 I peak at 42.8 cm in the Taal Lake core appears to be the signal of the Chernobyl accident in 1986. In addition, volcanic activities are reflected in the iodine isotope profiles in the sediment core, suggesting the potential of using iodine isotopes as an indicator of volcanic eruptions. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. A 60-year record of 129I in Taal Lake sediments (Philippines): Influence of human nuclear activities at low latitude region

    DEFF Research Database (Denmark)

    Zhang, Luyuan; Hou, Xiaolin; Li, Hong-chun

    2017-01-01

    in the Taal Lake core appears to be the signal of the Chernobyl accident in 1986. In addition, volcanic activities are reflected in the iodine isotope profiles in the sediment core, suggesting the potential of using iodine isotopes as an indicator of volcanic eruptions.......The influence of human nuclear activities on environmental radioactivity is not well known at low latitude region that are distant from nuclear tests sites and nuclear facilities. A sediment core collected from Taal Lake in the central Philippines was analyzed for 129I and 127I to investigate...

  1. Propagation of gravity waves and spread F in the low-latitude ionosphere over Tucumán, Argentina, by continuous Doppler sounding: First results

    Czech Academy of Sciences Publication Activity Database

    Chum, Jaroslav; Bonomi, F. A. M.; Fišer, Jiří; Cabrera, M. A.; Ezquer, R. G.; Burešová, Dalia; Laštovička, Jan; Baše, Jiří; Hruška, František; Molina, M. G.; Ise, J. E.; Cangemi, J. I.; Šindelářová, Tereza

    2014-01-01

    Roč. 119, č. 8 (2014), s. 6954-6965 ISSN 2169-9380 R&D Projects: GA ČR(CZ) GAP209/12/2440; GA ČR GP13-09778P Institutional support: RVO:68378289 Keywords : low latitude ionosphere * Ionospheric irregularities * equatorial spread F * gravity waves * scintillation * remote sensing * Doppler sounding Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 3.426, year: 2014 http://onlinelibrary.wiley.com/doi/10.1002/2014JA020184/abstract

  2. Daytime, low latitude, vertical ExB drift velocities, inferred from ground-based magnetometer observations in the Peruvian, Philippine and Indian longitude sectors under quiet and disturbed conditions

    CERN Document Server

    Anderson, D; Chau, J; Yumoto, K; Bhattacharya, A; Alex, S

    2006-01-01

    Daytime, low latitude, vertical ExB drift velocities, inferred from ground-based magnetometer observations in the Peruvian, Philippine and Indian longitude sectors under quiet and disturbed conditions

  3. A GIS-based assessment of the suitability of SCIAMACHY satellite sensor measurements for estimating reliable CO concentrations in a low-latitude climate.

    Science.gov (United States)

    Fagbeja, Mofoluso A; Hill, Jennifer L; Chatterton, Tim J; Longhurst, James W S

    2015-02-01

    An assessment of the reliability of the Scanning Imaging Absorption Spectrometer for Atmospheric Cartography (SCIAMACHY) satellite sensor measurements to interpolate tropospheric concentrations of carbon monoxide considering the low-latitude climate of the Niger Delta region in Nigeria was conducted. Monthly SCIAMACHY carbon monoxide (CO) column measurements from January 2,003 to December 2005 were interpolated using ordinary kriging technique. The spatio-temporal variations observed in the reliability were based on proximity to the Atlantic Ocean, seasonal variations in the intensities of rainfall and relative humidity, the presence of dust particles from the Sahara desert, industrialization in Southwest Nigeria and biomass burning during the dry season in Northern Nigeria. Spatial reliabilities of 74 and 42 % are observed for the inland and coastal areas, respectively. Temporally, average reliability of 61 and 55 % occur during the dry and wet seasons, respectively. Reliability in the inland and coastal areas was 72 and 38 % during the wet season, and 75 and 46 % during the dry season, respectively. Based on the results, the WFM-DOAS SCIAMACHY CO data product used for this study is therefore relevant in the assessment of CO concentrations in developing countries within the low latitudes that could not afford monitoring infrastructure due to the required high costs. Although the SCIAMACHY sensor is no longer available, it provided cost-effective, reliable and accessible data that could support air quality assessment in developing countries.

  4. Glendonites in Neoproterozoic low-latitude, interglacial, sedimentary rocks, northwest Canada: Insights into the Cryogenian ocean and Precambrian cold-water carbonates

    Science.gov (United States)

    James, Noel P.; Narbonne, Guy M.; Dalrymple, Robert W.; Kurtis Kyser, T.

    2005-01-01

    Stellate crystals of ferroan dolomite in neritic siliciclastic and carbonate sedimentary rocks between Sturtian and Marinoan glaciations in the Mackenzie Mountains are interpreted as replaced glendonites. These pseudomorphs after ikaite indicate that shallow seawater at that time was near freezing. Stromatolites verify that paleoenvironments were in the photic zone and physical sedimentary structures such as hummocky cross-bedding confirm that the seafloor was repeatedly disturbed by storms. Glendonites within these low-latitude, continental shelf to coastal sedimentary deposits imply that global ocean water during much of Cryogenian time was likely very cold. Such an ocean would easily have cooled to yield widespread sea ice and, through positive feedback, growth of low-latitude continental glaciers. In this situation gas hydrates could have formed in shallow-water, cold shelf sediment, but would have been particularly sensitive to destabilization as a result of sea-level change. Co-occurrence of pisolites and glendonites in these rocks additionally implies that some ooids and pisoids might have been, unlike Phanerozoic equivalents, characteristic of cold-water sediments.

  5. Sequential combination of glucocorticosteroids and alfa interferon versus alfa interferon alone chronic hepatitis B. Protocol for a Cochrane Review

    DEFF Research Database (Denmark)

    Mellerup, M T; Krogsgaard, K; Mathurin, P

    2000-01-01

    Chronic hepatitis B has serious effects on morbidity and mortality. Alfa interferon has been shown to increase the rates of HBeAg-clearance as well as seroconversion to anti-HBe, but response rates are unsatisfactory. Glucocorticosteroid pretreatment may increase the response to alfa interferon....

  6. Effects of polar field-aligned currents on the distribution of the electric field and current in the middle and low latitudes ionosphere

    International Nuclear Information System (INIS)

    Maekawa, Koichiro

    1978-01-01

    According to the analysis of the magnetic records from the Triad satellite, it has been found that there are two regions of the field-aligned current of magnetospheric origin along the auroral oval; Region 1 in higher latitude and Region 2 in lower latitude. These currents seem to have important effect on the distribution of electric field and current in the ionosphere, in addition to the Sq electric field and current of ionospheric origin. The global current systems generated by the field-aligned current were calculated, using some simplified ionospheric models. The effect of the field-aligned current on the distribution of electric field and current of the ionosphere at middle and low latitudes was investigated. (Yoshimori, M.)

  7. The Earth's passage of the April 11, 1997 coronal ejecta: geomagnetic field fluctuations at high and low latitude during northward interplanetary magnetic field conditions

    Directory of Open Access Journals (Sweden)

    S. Lepidi

    1999-10-01

    Full Text Available An analysis of the low frequency geomagnetic field fluctuations at an Antarctic (Terra Nova Bay and a low latitude (L'Aquila, Italy station during the Earth's passage of a coronal ejecta on April 11, 1997 shows that major solar wind pressure variations were followed at both stations by a high fluctuation level. During northward interplanetary magnetic field conditions and when Terra Nova Bay is close to the local geomagnetic noon, coherent fluctuations, at the same frequency (3.6 mHz and with polarization characteristics indicating an antisunward propagation, were observed simultaneously at the two stations. An analysis of simultaneous measurements from geosynchronous satellites shows evidence for pulsations at approximately the same frequencies also in the magnetospheric field. The observed waves might then be interpreted as oscillation modes, triggered by an external stimulation, extending to a major portion of the Earth's magnetosphere. Key words. Magnetospheric physics (MHD waves and instabilities; solar wind-magnetosphere interactions

  8. Integrating both interaction pathways between warming and pesticide exposure on upper thermal tolerance in high- and low-latitude populations of an aquatic insect.

    Science.gov (United States)

    Op de Beeck, Lin; Verheyen, Julie; Stoks, Robby

    2017-05-01

    Global warming and chemical pollution are key anthropogenic stressors with the potential to interact. While warming can change the impact of pollutants and pollutants can change the sensitivity to warming, both interaction pathways have never been integrated in a single experiment. Therefore, we tested the effects of warming and multiple pesticide pulses (allowing accumulation) of chlorpyrifos on upper thermal tolerance (CTmax) and associated physiological traits related to aerobic/anaerobic energy production in the damselfly Ischnura elegans. To also assess the role of latitude-specific thermal adaptation in shaping the impact of warming and pesticide exposure on thermal tolerance, we exposed larvae from replicated high- and low-latitude populations to the pesticide in a common garden rearing experiment at 20 and 24 °C, the mean summer water temperatures at high and low latitudes. As expected, exposure to chlorpyrifos resulted in a lower CTmax. Yet, this pesticide effect on CTmax was lower at 24 °C compared to 20 °C because of a lower accumulation of chlorpyrifos in the medium at 24 °C. The effects on CTmax could partly be explained by reduction of the aerobic scope. Given that these effects did not differ between latitudes, gradual thermal evolution is not expected to counteract the negative effect of the pesticide on thermal tolerance. By for the first time integrating both interaction pathways we were not only able to provide support for both of them, but more importantly demonstrate that they can directly affect each other. Indeed, the warming-induced reduction in pesticide impact generated a lower pesticide-induced climate change sensitivity (in terms of decreased upper thermal tolerance). Our results indicate that, assuming no increase in pesticide input, global warming might reduce the negative effect of multiple pulse exposures to pesticides on sensitivity to elevated temperatures. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Pathogenic fungi and parasitoids of aphids present in air captures of migratory alates in the low-latitude plateau of Yunnan, China.

    Science.gov (United States)

    Huang, Zhi-Hong; Feng, Ming-Guang; Chen, Xue-Xin; Liu, Shu-Sheng

    2008-10-01

    To survey fungal pathogens and parasitoids of aphids in the low-latitude plateau of Yunnan, southwest China, 3,553 migratory alates of Brevicoryne brassicae, Lipaphis erysimi, and Myzus persicae were attracted to a yellow-plus-plant trap from air during a full-year period and individually reared on cabbage leaves for 7-14 d at 18-22 degrees C and L:D 12:12. Among the trapped alates, 19.2% were killed by 10 species of aphid-pathogenic fungi after survival of 2.3 d (range, 1-7 d). Another 2.8% were mummified by the wasps Aphidius gifuensis, Diaeretella rapae, Ephedrus plagiator, and Aphelinus mali after survival of 4.9 d (range, 1-11 d). Most of the mycosed alates (77.8%) died from Entomophthorales predominated by Pandora neoaphidis (42.7%) and Zoophthora radicans (14.5%), followed by P. nouryi, Neozygites fresenii, Conidiobiolus spp., Entomophthora planchoniana, and Z. aphidis in decreasing frequencies. A mitosporic fungus, Lecanicillium lecanii, was found frequently in L. erysimi alates trapped in rainy season. However, B. brassicae alates captured in dry season were infected or parasitized very occasionally. The predeath fecundity of the infected or parasitized alates warranted successful colonization on plants, although greatly reduced, and was well shown by the fitted probability for a given fecundity per capita and the increasing mean size of their progeny colonies. Contagious transmission of the alate-borne mycosis in most of the colonies caused high progeny mortalities within 14 d. The results highlight for the first time the diversity of aphid pathogens and the spread of both pathogens and parasitoids with host dispersal flight in the low-latitude plateau.

  10. Humpback whale "super-groups" - A novel low-latitude feeding behaviour of Southern Hemisphere humpback whales (Megaptera novaeangliae) in the Benguela Upwelling System.

    Science.gov (United States)

    Findlay, Ken P; Seakamela, S Mduduzi; Meÿer, Michael A; Kirkman, Stephen P; Barendse, Jaco; Cade, David E; Hurwitz, David; Kennedy, Amy S; Kotze, Pieter G H; McCue, Steven A; Thornton, Meredith; Vargas-Fonseca, O Alejandra; Wilke, Christopher G

    2017-01-01

    Southern Hemisphere humpback whales (Megaptera novaeangliae) generally undertake annual migrations from polar summer feeding grounds to winter calving and nursery grounds in subtropical and tropical coastal waters. Evidence for such migrations arises from seasonality of historic whaling catches by latitude, Discovery and natural mark returns, and results of satellite tagging studies. Feeding is generally believed to be limited to the southern polar region, where Antarctic krill (Euphausia superba) has been identified as the primary prey item. Non-migrations and / or suspended migrations to the polar feeding grounds have previously been reported from a summer presence of whales in the Benguela System, where feeding on euphausiids (E. lucens), hyperiid amphipods (Themisto gaudichaudii), mantis shrimp (Pterygosquilla armata capensis) and clupeid fish has been described. Three recent research cruises (in October/November 2011, October/November 2014 and October/November 2015) identified large tightly-spaced groups (20 to 200 individuals) of feeding humpback whales aggregated over at least a one-month period across a 220 nautical mile region of the southern Benguela System. Feeding behaviour was identified by lunges, strong milling and repetitive and consecutive diving behaviours, associated bird and seal feeding, defecations and the pungent "fishy" smell of whale blows. Although no dedicated prey sampling could be carried out within the tightly spaced feeding aggregations, observations of E. lucens in the region of groups and the full stomach contents of mantis shrimp from both a co-occurring predatory fish species (Thyrsites atun) and one entangled humpback whale mortality suggest these may be the primary prey items of at least some of the feeding aggregations. Reasons for this recent novel behaviour pattern remain speculative, but may relate to increasing summer humpback whale abundance in the region. These novel, predictable, inter-annual, low latitude feeding events

  11. Analysis of geomagnetically induced currents at a low-latitude region over the solar cycles 23 and 24: comparison between measurements and calculations

    Directory of Open Access Journals (Sweden)

    Barbosa Cleiton

    2015-01-01

    Full Text Available Geomagnetically Induced Currents (GIC are a space weather effect, which affects ground-based technological structures at all latitudes on the Earth’s surface. GIC occurrence and amplitudes have been monitored in power grids located at high and middle latitudes since 1970s and 1980s, respectively. This monitoring provides information about the GIC intensity and the frequency of occurrence during geomagnetic storms. In this paper, we investigate GIC occurrence in a power network at low latitudes (in the central Brazilian region during the solar cycles 23 and 24. Calculated and measured GIC data are compared for the most intense geomagnetic storms (i.e. −50 < Dst < −50 nT of the solar cycle 24. The results obtained from this comparison show a good agreement. The success of the model employed for the calculation of GIC leads to the possibility of determining GIC for events during the solar cycle 23 as well. Calculated GIC in one transformer reached ca. 30 A during the “Halloween storm” in 2003 whilst most frequent intensities lie below 10 A. The normalized inverse cumulative frequency for GIC data was calculated for the solar cycle 23 in order to perform a statistical analysis. It was found that a q-exponential Tsallis distribution fits the calculated GIC frequency distribution for more than 99% of the data. This analysis provides an overview of the long-term GIC monitoring at low latitudes and suggests new insight into critical phenomena involved in the GIC generation.

  12. Simulation of low-latitude ionospheric response to 2015 St. Patrick's Day super geomagnetic storm using ionosonde-derived PRE vertical drifts over Indian region

    Science.gov (United States)

    Joshi, L. M.; Sripathi, S.; Singh, Ram

    2016-03-01

    In this paper, we present low-latitude ionospheric response over Indian longitude to the recent super geomagnetic storm of 17 March 2015, using the Sami2 is Another Model of the Ionosphere (SAMI2) model which incorporates ionosonde-derived vertical drift impacted by prompt penetration eastward electric field occurring during the evening prereversal enhancement (PRE) in the vertical drift. The importance of this storm is that (1) Dst reaches as low as -228 nT and (2) prompt penetration of eastward electric field coincided with evening hours PRE. The daytime vertical E × B drifts in the SAMI2 model are, however, considered based on Scherliess-Fejer model. The simulations indicate a significant enhancement in F layer height and equatorial ionization anomaly (EIA) in the post sunset hours on 17 March 2015 vis-a-vis quiet day. The model simulations during recovery phase, considering disturbance dynamo vertical E × B drift along with equatorward disturbance wind, indicate suppression of the daytime EIA. SAMI2 simulations considering the disturbance wind during the recovery phase suggest that equatorward wind enhances the ionospheric density in the low latitude; however, its role in the formation of the EIA depends on the polarity of the zonal electric field. Comparison of model derived total electron content (TEC) with the TEC from ground GPS receivers indicates that model does reproduce enhancement of the EIA during the main phase and suppression of the EIA during the recovery phase of the superstorm. However, peculiarities pertaining to the ionospheric response to prompt penetration electric field in the Indian sector vis-a-vis earlier reports from American sector have been discussed.

  13. First Evaluation of the Climatological Calibration Algorithm in the Real-time TMPA Precipitation Estimates over Two Basins at High and Low Latitudes

    Science.gov (United States)

    Yong, Bin; Ren, Liliang; Hong, Yang; Gourley, Jonathan; Tian, Yudong; Huffman, George J.; Chen, Xi; Wang, Weiguang; Wen, Yixin

    2013-01-01

    The TRMM Multi-satellite Precipitation Analysis (TMPA) system underwent a crucial upgrade in early 2009 to include a climatological calibration algorithm (CCA) to its realtime product 3B42RT, and this algorithm will continue to be applied in the future Global Precipitation Measurement era constellation precipitation products. In this study, efforts are focused on the comparison and validation of the Version 6 3B42RT estimates before and after the climatological calibration is applied. The evaluation is accomplished using independent rain gauge networks located within the high-latitude Laohahe basin and the low-latitude Mishui basin, both in China. The analyses indicate the CCA can effectively reduce the systematic errors over the low-latitude Mishui basin but misrepresent the intensity distribution pattern of medium-high rain rates. This behavior could adversely affect TMPA's hydrological applications, especially for extreme events (e.g., floods and landslides). Results also show that the CCA tends to perform slightly worse, in particular, during summer and winter, over the high-latitude Laohahe basin. This is possibly due to the simplified calibration-processing scheme in the CCA that directly applies the climatological calibrators developed within 40 degrees latitude to the latitude belts of 40 degrees N-50 degrees N. Caution should therefore be exercised when using the calibrated 3B42RT for heavy rainfall-related flood forecasting (or landslide warning) over high-latitude regions, as the employment of the smooth-fill scheme in the CCA bias correction could homogenize the varying rainstorm characteristics. Finally, this study highlights that accurate detection and estimation of snow at high latitudes is still a challenging task for the future development of satellite precipitation retrievals.

  14. Humpback whale "super-groups" - A novel low-latitude feeding behaviour of Southern Hemisphere humpback whales (Megaptera novaeangliae in the Benguela Upwelling System.

    Directory of Open Access Journals (Sweden)

    Ken P Findlay

    Full Text Available Southern Hemisphere humpback whales (Megaptera novaeangliae generally undertake annual migrations from polar summer feeding grounds to winter calving and nursery grounds in subtropical and tropical coastal waters. Evidence for such migrations arises from seasonality of historic whaling catches by latitude, Discovery and natural mark returns, and results of satellite tagging studies. Feeding is generally believed to be limited to the southern polar region, where Antarctic krill (Euphausia superba has been identified as the primary prey item. Non-migrations and / or suspended migrations to the polar feeding grounds have previously been reported from a summer presence of whales in the Benguela System, where feeding on euphausiids (E. lucens, hyperiid amphipods (Themisto gaudichaudii, mantis shrimp (Pterygosquilla armata capensis and clupeid fish has been described. Three recent research cruises (in October/November 2011, October/November 2014 and October/November 2015 identified large tightly-spaced groups (20 to 200 individuals of feeding humpback whales aggregated over at least a one-month period across a 220 nautical mile region of the southern Benguela System. Feeding behaviour was identified by lunges, strong milling and repetitive and consecutive diving behaviours, associated bird and seal feeding, defecations and the pungent "fishy" smell of whale blows. Although no dedicated prey sampling could be carried out within the tightly spaced feeding aggregations, observations of E. lucens in the region of groups and the full stomach contents of mantis shrimp from both a co-occurring predatory fish species (Thyrsites atun and one entangled humpback whale mortality suggest these may be the primary prey items of at least some of the feeding aggregations. Reasons for this recent novel behaviour pattern remain speculative, but may relate to increasing summer humpback whale abundance in the region. These novel, predictable, inter-annual, low latitude

  15. Abnormal distribution of low-latitude ionospheric electron density during November 2004 superstorm as reconstructed by 3-D CT technique from IGS and LEO/GPS observations

    Science.gov (United States)

    Xiao, R.; Ma, S.; Xu, J.; Xiong, C.; Yan, W.; Luhr, H.; Jakowski, N.

    2010-12-01

    Using time-dependent 3-D tomography method, the electron density distributions in the mid- and low-latitude ionosphere are reconstructed from GPS observations of joint ground-based IGS network and onboard CHAMP/GRACE satellites during November 2004 super-storm. For LEO satellite-based GPS receiving, both the occultation TEC data and that along the radio propagation paths above the LEO are used. The electron density images versus latitude/altitude/longitude are reconstructed for different sectors of America/Asia/Europe and produced every hour. The reconstructed electron densities are validated by satellite in situ measurements of CHAMP Langmuir probe and GRACE Ka-band SST (low-low satellite-to-satellite tracking) derived electron density averaged between the two satellites, as well as by CIT simulations. It reveals some very interesting storm-time structures of Ne distributions, such as top-hat-like F2-3 double layer and column-like enhanced electron densities (CEED). The double layer structure appeared over a large latitude range from about -30 degree to 20 degree along East-Asian/Australia longitudes before local noon, looking like one additional smaller EIA structure standing above the usual one of EIA. It is consistent with the F-3 layer observed by ionosonde at an Australian low-latitude station. The CEED are found just 1-2 hours before the minimum of Dst and in the longitudinal sector about 157 E. They extend from the topside ionosphere toward plasmasphere, reaching at least about 2000 km as high. Their footprints stand on the two peaks of the EIA. This CEED is also seen in the image of 30.4 nm He ++ radiation by IMAGE, showing a narrow channel of enhanced density extending from afternoon ionosphere to plasmsphere westward. The forming mechanism of CEED and its relationship with SED and plasmaspheric plumes are worthy of further study. Acknowledgement: This work is supported by NSFC (No.40674078).

  16. H I superclouds in the inner Galaxy

    International Nuclear Information System (INIS)

    Elmegreen, B.G.; Elmegreen, D.M.; IBM Watson Research Center, Yorktown Heights; Vassar College Observatory, Poughkeepsie, NY)

    1987-01-01

    Atomic hydrogen clouds in the Weaver-Williams 21 cm survey are found in the vicinity of the largest molecular cloud complexes in the first Galactic quadrant. The atomic masses are estimated in several ways, including a new method where the clouds are assumed to be composed of cool clumps immersed in a warm interclump medium. The clouds are found to contain between a million and 40 million solar masses of atoms at an average density of about 9/cu cm. They appear gravitationally bound, their molecular mass fractions decrease from 70 percent to 5 percent with increasing distance from the Galactic center, and they are located in the spiral arms. The importance of these clouds for the large-scale distributions of interstellar mass, molecular fraction, and star formation is discussed. 103 references

  17. JSC “ALFA-BANK” marketing policy. problems and perspectives

    OpenAIRE

    Kirillov, A.; Kuznetcova, E.; Martirosian, M.

    2013-01-01

    The article is devoted to the results of JSC “Alfa-Bank” consumers’ segmentation and the following complex marketing research. The article suggests the ways of the bank’s marketing policy improvement.

  18. Treatment of anemia with darbepoetin alfa in systolic heart failure

    DEFF Research Database (Denmark)

    Swedberg, Karl; Young, James B; Anand, Inder S

    2013-01-01

    Patients with systolic heart failure and anemia have worse symptoms, functional capacity, and outcomes than those without anemia. We evaluated the effects of darbepoetin alfa on clinical outcomes in patients with systolic heart failure and anemia.......Patients with systolic heart failure and anemia have worse symptoms, functional capacity, and outcomes than those without anemia. We evaluated the effects of darbepoetin alfa on clinical outcomes in patients with systolic heart failure and anemia....

  19. C+/CO Transitions in the Diffuse ISM: Transitional Cloud Sample from the GOT C+ Survey of [CII] in the inner Galaxy at l = -30deg to 30deg

    Science.gov (United States)

    Velusamy, T.; Pineda, J. L.; Langer, W. D.; Willacy, K.; Goldsmith, P. F.

    2011-05-01

    Our knowledge of interstellar gas has been limited primarily to the diffuse atomic phase traced by HI and the well-shielded molecular phase traced by CO. Recently, using the first results of the Herschel Key Project GOT C+, a HIFI C+ survey of the Galactic plane, Velusamy, Langer, Pineda et al. (A&A 521, L18, 2010) have shown that in the diffuse interstellar transition clouds a significant fraction of the carbon exists primarily as C^+ with little C^0 and CO in a warm 'dark gas' layer in which hydrogen is mostly H_2 with little atomic H, surrounding a modest 12CO-emitting core. The [CII] fine structure transition, at 1.9 THz (158 μm) is the best tracer of this component of the interstellar medium, which is critical to our understanding of the atomic to molecular cloud transitions. The Herschel Key Project GOT C+ is designed to study such clouds by observing with HIFI the [CII] line emission along 500 lines of sight (LOSs) throughout the Galactic disk. Here we present the identification and chemical status of a few hundred diffuse and transition clouds traced by [CII], along with auxiliary HI and CO data covering ~100 LOSs in the inner Galaxy between l= -30° and 30°. We identify transition clouds as [CII] components that are characterized by the presence of both HI and 12CO, but no 13CO emission. The intensities, I(CII) and I(HI), are used as measures of the visual extinction, AV, in the cloud up to the C^+/C^0/CO transition layer and a comparison with I(12CO) yields a more complete H_2 molecular inventory. Our results show that [CII] emission is an excellent tool to study transition clouds and their carbon chemistry in the ISM, in particular as a unique tracer of molecular H_2, which is not easily observed by other means. The large sample presented here will serve as a resource to study the chemical and physical status of diffuse transition clouds in a wide range of Galactic environments and constrain the physical parameters such as the FUV intensity and cosmic

  20. On the response of the equatorial and low latitude ionospheric regions in the Indian sector to the large magnetic disturbance of 29 October 2003

    Directory of Open Access Journals (Sweden)

    G. Manju

    2009-06-01

    Full Text Available The present paper investigates the response of the equatorial and low latitude ionosphere over the Indian longitudes to the events on 29 October 2003 using ionosonde data at Trivandrum (8.5° N (0.5° N geomagnetic, 77° E and SHAR (13.7° N (5.7° N geomagnetic, 80.2° E, ground-based magnetometer data from Trivandrum and Total Electron Content (TEC derived from GPS data at the locations of Ahmedabad (23° N (15° N geomagnetic, 72° E, Jodhpur (26.3° N (18.3° N geomagnetic, 73° E and Delhi (28° N (20° N geomagnetic, 77° E. Following the storm sudden commencement, the TEC at all the three stations showed an overall enhancement in association with episodes of inter-planetary electric field penetration. Interestingly, real ionospheric height profiles derived using the ionosonde data at both Trivandrum and SHAR showed significant short-term excursions and recoveries. In the post noon sector, these features are more pronounced over SHAR, an off equatorial station, than those over Trivandrum indicating the increased effects of neutral winds.

  1. Longitudinal and Seasonal Variations of the Electron Temperature and Density in the Low-Latitude Topside Ionosphere Observed by KOMPSAT-1

    Directory of Open Access Journals (Sweden)

    Heejun Kim

    2002-06-01

    Full Text Available The electron density and temperature in the topside ionosphere are observed by the Ionosphere Measurement Sensor (IMS onboard the KOMPSAT-1, which has the sun-synchronous orbit of the altitude of 685 km and the orbital inclination of 98deg with a descending node at 22:50LT. Observations have been analyzed to determine the seasonal variations of the electron density and temperature in the low-latitude region. Only the night-time (22:50LT behavior on magnetically quiet days (Kp < 4 has been examined. Observations show a strong longitudinal and seasonal variation. Generally, in the dip equator the density increases and the temperature decreases. In equinox the latitudinal distributions of the electron density and temperature are quite symmetric about the dip equator. However, the local maximum of the density and the local minimum of the temperature shift toward the Northern hemisphere in summer solstice but the Southern hemisphere in winter solstice. Such variations are due to the influences of field-aligned plasma transport induced by F region neutral wind. Compared with the IRI95 model, the observed electron density and temperature show significant differences from those predicted by the IRI95 model.

  2. Lidar observations of middle atmospheric gravity wave activity over a low-latitude site (Gadanki, 13.5° N, 79.2° E

    Directory of Open Access Journals (Sweden)

    V. Sivakumar

    2006-05-01

    Full Text Available The low-latitude middle atmospheric gravity wave characteristics are presented using 310 nights of Rayleigh lidar observations made at Gadanki (13.5° N, 79.2° E over the period from March 1998 to December 2002. The gravity wave characteristics are presented in terms of vertical wave number and frequency spectra, along with the estimated potential energy for the four seasons, namely, spring, summer, autumn and winter. The computed wave number spectra for both the stratosphere and the mesosphere are found to differ significantly from a saturated model predicted spectrum. The spectra were found to be shallower at lower wave numbers and steeper at higher wave numbers with transition at ~8.85×10-4 cy/m. The computed frequency spectra seem to follow the model plot with a power law index of -5/3 above a frequency of ~2×10-4 Hz. The estimated potential energy per unit mass increases gradually up to ~60 km and then rather rapidly above this height to reach values of the order of 200J/kg at ~70 km.

  3. Comparison of electron density profiles observed in China's low latitude station with that produced by the International Reference Ionosphere (IRI2001)

    International Nuclear Information System (INIS)

    Zhang Manlian; Shi Jiankui; Wang Xiao

    2003-01-01

    One month's data of ionograms observed by DPS-4 digisonde in China's low latitude station Hainan (19.4 deg N/109.0 deg E) for the high solar activity year 2002 is used to make a comparison study between the observational electron density profiles and that produced by the newly updated International Reference Ionosphere (IRI2001). The present study showed that for the month studied (April, 2002): (1) When B0-Tab value is used, profiles given by IRI2001 are in poor agreement with the observational results during daytime and nearby midnight hours when standard Ne(h) option is chosen, whereas when the LAY functions version is chosen, IRI2001 produces profiles with erroneous features during evening and nighttime hours, although it produces profiles in a reasonable good agreement with the observational ones during daytime hours. (2) In general, profiles produced by IRI2001 with B0-Gulyaeva choice is in better agreement with observational profiles than when B0-Tab is chosen. When the B0-Gulyaeva and LAY functions version of Ne(h) are both chosen, IRI2001 produced the best results when compared with the observational results. (3) The B0 parameter given by B0-Gulyaeva choice in IRI2001 is much closer to the observed (best fitted) one than that given by the B0-Tab choice is. (author)

  4. Managing anemia with epoetin alfa in patients with rectal cancer

    International Nuclear Information System (INIS)

    Velenik, V.; Oblak, I.; Kodre, V.

    2005-01-01

    Background. Anemia is one of the most challenging problems in clinical oncology due to its high prevalence among the patients with malignant diseases. The purposes of our study were: (1) to assess the potential of epoetin alfa therapy to prevent the decline in Hb concentrations that typically accompanies chemotherapy/ radiotherapy (ChT/RT) of the patients with rectal cancer; (2) to test the hypothesis that the use of epoetin alfa significantly reduces the transfusion requirements in the patients with rectal cancer treated with ChT/RT after surgery, and (3) to evaluate the safety profile of the administration of epoetin alfa in the clinical setting. Methods. Sixty patients who underwent surgery for rectal cancer were prospectively enrolled. Group A consisted of 39 patients with Hb concentrations ≤13 g/dl at the start of ChT/RT following surgery, and group B of 17 patients with Hb concentrations ≥13 g/dl at the start of ChT/RT following surgery, but whose Hb concentrations fell below 13 g/dl during the ChT/RT protocol. The starting dose of epoetin alfa in both groups was 10,000 IU subcutaneously (sc) three times a week (tiw). The following major parameters were evaluated: (1) change in Hb concentrations relative to the baseline as measured at 4-week intervals, (2) allogenic blood transfusion requirements in relation to Hb concentrations, and (3) incidence and severity of adverse events and their potential relationship to epoetin alfa administration. Results. The study protocol was completed in 56/60 patients. In group A, a statistically significant increase in Hb concentration (p<0.001) was observed after the first 4 weeks of epoetin alfa treatment compared to the baseline values, with the mean increase of Hb concentration of 1.97 g/dl ± 0.91 g/dl and Hb concentrations remained significantly increased through the whole study (p=0.0017). In group B, a continuous decrease in Hb concentrations was observed during the first weeks of therapy, reaching the level of

  5. Peginterferon alfa-2b and ribavirin: effective in patients with hepatitis C who failed interferon alfa/ribavirin therapy.

    Science.gov (United States)

    Poynard, Thierry; Colombo, Massimo; Bruix, Jordi; Schiff, Eugene; Terg, Ruben; Flamm, Steven; Moreno-Otero, Ricardo; Carrilho, Flair; Schmidt, Warren; Berg, Thomas; McGarrity, Thomas; Heathcote, E Jenny; Gonçales, Fernando; Diago, Moises; Craxi, Antonio; Silva, Marcelo; Bedossa, Pierre; Mukhopadhyay, Pabak; Griffel, Louis; Burroughs, Margaret; Brass, Clifford; Albrecht, Janice

    2009-05-01

    Treatment with peginterferon alfa and ribavirin produces a sustained virologic response (SVR) in approximately 60% of hepatitis C virus (HCV)-infected patients. Alternate options are needed for patients who relapse or do not respond to therapy. This prospective, international, multicenter, open-label study evaluated efficacy and safety of peginterferon alfa-2b (1.5 microg/kg/wk) plus weight-based ribavirin (800-1400 mg/day) in 2333 chronic HCV-infected patients with significant fibrosis/cirrhosis whose previous interferon alfa/ribavirin therapy failed. Patients with undetectable HCV-RNA at treatment week (TW) 12 received 48 weeks of therapy; patients with detectable HCV-RNA at TW12 could enter maintenance studies at TW18; 188 patients with low/detectable HCV-RNA at TW12 continued therapy at the investigator's request. Overall, 22% of the patients attained SVR (56% with undetectable HCV-RNA and 12% with low/detectable HCV-RNA at TW12). SVR was better in relapsers (38%) than nonresponders (14%), regardless of previous treatment, and in patients previously treated with interferon-alfa/ribavirin (25%) than peginterferon alfa-ribavirin (17%). Predictors of response in patients with undetectable HCV-RNA at TW12 were genotype (2/3 vs 1, respectively; odds ratio [OR] 2.4; P 600,000 IU/mL; OR, 1.4; P = .0223). These factors plus previous treatment and response were overall predictors of SVR. Safety was similar among fibrosis groups. Peginterferon alfa-2b plus weight-based ribavirin is effective and safe in patients who failed interferon alfa/ribavirin therapy. Genotype, baseline viral load, and fibrosis stage were predictors of response.

  6. Rayleigh LiDAR investigation of stratospheric sudden warming over a low latitude station, Gadanki (13.5ºN; 79.2ºE) – a statistical study

    CSIR Research Space (South Africa)

    Charyulu, DV

    2007-08-01

    Full Text Available In this paper, the authors report the statistical characteristics of Stratospheric Sudden Warming (SSW) events observed over a low latitude station, Gadanki; 13.5°N, 79.2°E. The study uses 7 years (1998 to 2004) of quasi-continuous nighttime Li...

  7. Darbepoetin alfa once every 2 weeks for treatment of anemia in dialysis patients

    DEFF Research Database (Denmark)

    Mann, J; Kessler, M; Villa, Giulio Palludan

    2007-01-01

    AIM: Darbepoetin alfa has a longer half-life than epoetin-(EPO) alfa or beta, allowing administration at less frequent intervals for the treatment of renal anemia. The aim of the present analysis was to evaluate the efficacy and tolerability of an every-2-week (Q2W) schedule of darbepoetin alfa...

  8. Resolution and t-spectrum for the ALFA detector

    CERN Document Server

    Guergouri, Hichem

    2016-01-01

    My report as Summer Student is in two parts. In the first part I report about my attendance to the run of the ALFA detector to test different collimation schemas and find a new way to get rid of the background. The second part is about the measurement of the resolution of the ALFA detector and comparing the real data with the Monte-Carlo (MC) simulations. First of all I tried to be more familiar with ROOT, worked on understanding the code used to access to the data in the trees inside the Ntuples, plotting histograms,… This was done using old Ntuples which contain MC data.

  9. Simulation studies on the tomographic reconstruction of the equatorial and low-latitude ionosphere in the context of the Indian tomography experiment: CRABEX

    Directory of Open Access Journals (Sweden)

    S. V. Thampi

    2004-11-01

    Full Text Available Equatorial ionosphere poses a challenge to any algorithm that is used for tomographic reconstruction because of the phenomena like the Equatorial Ionization Anomaly (EIA and Equatorial Spread F (ESF. Any tomographic reconstruction of ionospheric density distributions in the equatorial region is not acceptable if it does not image these phenomena, which exhibit large spatial and temporal variability, to a reasonable accuracy. The accuracy of the reconstructed image generally depends on many factors, such as the satellite-receiver configuration, the ray path modelling, grid intersections and finally, the reconstruction algorithm. The present simulation study is performed to examine these in the context of the operational Coherent Radio Beacon Experiment (CRABEX network just commenced in India. The feasibility of using this network for the studies of the equatorial and low-latitude ionosphere over Indian longitudes has been investigated through simulations. The electron density distributions that are characteristic of EIA and ESF are fed into various simulations and the reconstructed tomograms are investigated in terms of their reproducing capabilities. It is seen that, with the present receiver chain existing from 8.5° N to 34° N, it would be possible to obtain accurate images of EIA and the plasma bubbles. The Singular Value Decomposition (SVD algorithm has been used for the inversion procedure in this study. As is known, by the very nature of ionospheric tomography experiments, the received data contain various kinds of errors, like the measurement and discretization errors. The sensitivity of the inversion algorithm, SVD in the present case, to these errors has also been investigated and quantified.

  10. Study of the Equatorial and Low-Latitude Electrodynamic and Ionospheric Disturbances During the 22-23 June 2015 Geomagnetic Storm Using Ground-Based and Spaceborne Techniques

    Science.gov (United States)

    Astafyeva, E.; Zakharenkova, I.; Hozumi, K.; Alken, P.; Coïsson, P.; Hairston, M. R.; Coley, W. R.

    2018-03-01

    We use a set of ground-based instruments (Global Positioning System receivers, ionosondes, magnetometers) along with data of multiple satellite missions (Swarm, C/NOFS, DMSP, GUVI) to analyze the equatorial and low-latitude electrodynamic and ionospheric disturbances caused by the geomagnetic storm of 22-23 June 2015, which is the second largest storm in the current solar cycle. Our results show that at the beginning of the storm, the equatorial electrojet (EEJ) and the equatorial zonal electric fields were largely impacted by the prompt penetration electric fields (PPEF). The PPEF were first directed eastward and caused significant ionospheric uplift and positive ionospheric storm on the dayside, and downward drift on the nightside. Furthermore, about 45 min after the storm commencement, the interplanetary magnetic field (IMF) Bz component turned northward, leading to the EEJ changing sign to westward, and to overall decrease of the vertical total electron content (VTEC) and electron density on the dayside. At the end of the main phase of the storm, and with the second long-term IMF Bz southward turn, we observed several oscillations of the EEJ, which led us to conclude that at this stage of the storm, the disturbance dynamo effect was already in effect, competing with the PPEF and reducing it. Our analysis showed no significant upward or downward plasma motion during this period of time; however, the electron density and the VTEC drastically increased on the dayside (over the Asian region). We show that this second positive storm was largely influenced by the disturbed thermospheric conditions.

  11. Day and nighttime L-Band amplitude scintillations during low solar activity at a low latitude station in the South Pacific region

    Science.gov (United States)

    Prasad, Ramendra; Kumar, Sushil

    2017-12-01

    A morphological study of GPS L-band amplitude scintillations observed at a low latitude station, Suva (18.1°S, 178.4°E), Fiji, during low solar activity year 2010 of solar cycle 24, has been presented. Out of a total of 480 scintillation events recorded during 2010, 84.4% were weak (0.2 ≤ S4 < 0.3), 14.6% moderate (0.3 ≤ S4 < 0.45) and only 1% strong (0.45 ≤ S4). The amplitude scintillations were most pronounced in the local daytime with January registering the highest occurrence. Seasonal analysis revealed maximum scintillation occurrence during summer as compared to winter and equinox seasons. The daytime scintillation with a maximum in the summer is consistent with localized blanketing sporadic E observations and could also be possibly due to lightning activity around the observing station. Annual percentage occurrence shows that scintillations occurred mostly in the daytime with peak occurrence at around 05:00-09:00 LT. The daytime strong scintillation events were not associated with vTEC depletions and phase scintillations, but the signal to noise ratio during the scintillation events decreased with increase in scintillation index (S4). However, the post-midnight strong amplitude scintillations were associated with vTEC depletions and phase scintillations indicative of large scale irregularities (spread-F). The geomagnetic activity effect showed enhanced occurrence on geomagnetically disturbed days as compared to quite conditions. The geomagnetic storm effect on scintillations for 17 storms of different strengths (Dst ≤ 50 nT) during 2010-2011 showed an increase in the occurrence of post-storm scintillations, on the days following the storm.

  12. Accounting for observation uncertainties in an evaluation metric of low latitude turbulent air-sea fluxes: application to the comparison of a suite of IPSL model versions

    Science.gov (United States)

    Servonnat, Jérôme; Găinuşă-Bogdan, Alina; Braconnot, Pascale

    2017-09-01

    Turbulent momentum and heat (sensible heat and latent heat) fluxes at the air-sea interface are key components of the whole energetic of the Earth's climate. The evaluation of these fluxes in the climate models is still difficult because of the large uncertainties associated with the reference products. In this paper we present an objective metric accounting for reference uncertainties to evaluate the annual cycle of the low latitude turbulent fluxes of a suite of IPSL climate models. This metric consists in a Hotelling T 2 test between the simulated and observed field in a reduce space characterized by the dominant modes of variability that are common to both the model and the reference, taking into account the observational uncertainty. The test is thus more severe when uncertainties are small as it is the case for sea surface temperature (SST). The results of the test show that for almost all variables and all model versions the model-reference differences are not zero. It is not possible to distinguish between model versions for sensible heat and meridional wind stress, certainly due to the large observational uncertainties. All model versions share similar biases for the different variables. There is no improvement between the reference versions of the IPSL model used for CMIP3 and CMIP5. The test also reveals that the higher horizontal resolution fails to improve the representation of the turbulent surface fluxes compared to the other versions. The representation of the fluxes is further degraded in a version with improved atmospheric physics with an amplification of some of the biases in the Indian Ocean and in the intertropical convergence zone. The ranking of the model versions for the turbulent fluxes is not correlated with the ranking found for SST. This highlights that despite the fact that SST gradients are important for the large-scale atmospheric circulation patterns, other factors such as wind speed, and air-sea temperature contrast play an

  13. Variabilities of Low-Latitude Migrating and Nonmigrating Tides in GPS-TEC and TIMED-SABER Temperature During the Sudden Stratospheric Warming Event of 2013

    Science.gov (United States)

    Sridharan, S.

    2017-10-01

    The Global Positioning System deduced total electron content (TEC) data at 15°N (geomagnetic), which is the crest region of equatorial ionization anomaly, are used to study tidal variabilities during the 2013 sudden stratospheric warming (SSW) event. The results from space-time spectral analysis reveal that the amplitudes of migrating diurnal (DW1) and semidiurnal (SW2) tides are larger than those of nonmigrating tides. After the SSW onset, the amplitudes of DW1, SW2, SW1, and DS0 increase. Moreover, they show 16 day variations similar to the periodicity of the high-latitude stratospheric planetary wave (PW), suggesting that the nonmigrating tides (SW1 and DS0) are possibly generated due to nonlinear interaction of migrating tides with PW. Similar spectral analysis on temperature at 10°N obtained from the Sounding of Atmosphere by Broadband Emission Radiometry (SABER) shows that the SW2 enhances at stratospheric heights and the SW2 is more dominant at 80-90 km, but its amplitude decreases around 100 km. The amplitudes of nonmigrating tides become comparable to those of SW2 around 100 km, and their contribution becomes increasingly important at higher heights. This suggests that the nonlinear interaction between migrating tides and PW occurs at low-latitude upper mesospheric heights, as SW2 exhibits 16 day periodicity in SABER temperature at 100 km as observed in TEC. Besides, it is observed that the eastward propagating tides are less dominant than westward propagating tides in both TEC and SABER temperatures.

  14. O2 nightglow snapshots of the 1.27 μm emission at low latitudes on Mars with a static field-widened Michelson interferometer

    Science.gov (United States)

    Zhang, Rui; Ward, William E.; Zhang, Chunmin

    2017-12-01

    A static field-widened Michelson interferometer is designed to observe the atmospheric dynamics at low latitudes of Mars, targeting the 1.27 μm O2(a1Δg) nightglow, which has not yet been accurately detected due to its low intensity. To the best of our knowledge, this design is the first demonstration of implementing divided-mirror technique by refringent materials in a field-widened Michelson interferometer. Different optical path difference (OPD) in each quadrant is generated by four highly reflective pyramid-shaped prisms made of different refringent materials attached to each solid arm of Michelson interferometer. In this way four samples of interferogram are obtained simultaneously, from which the airglow volume emission rate, as well as the line-of-sight velocity and temperature of the air parcel where the emission forms can be derived in a single integration time. To achieve the best field-widening, compactness and thermal compensation, all possible combination of ten pieces of glasses were searched within the Sumita glass catalogue using a computer program and some interesting results are listed. The OPD used in this calculation concerns rays in the plane perpendicular to the sides of the prism only, other cases need further examination. This instrument's performance in measuring atmospheric dynamics is analysed, using the wind velocity uncertainty as primary criterion. Calculations show that it can measure the wind with an accuracy better than 2 m/s if the band volume emission rate of O2 nightglow is greater than 5 kph cm-3 s-1.

  15. VHF and L-band scintillation characteristics over an Indian low latitude station, Waltair (17.7° N, 83.3° E

    Directory of Open Access Journals (Sweden)

    P. V. S. Rama Rao

    2005-10-01

    Full Text Available Characteristics of simultaneous VHF (244 MHz and L-band (1.5 GHz scintillations recorded at a low-latitude station, Waltair (17.7° N, 83.3° E, during the low sunspot activity year of March 2004 to March 2005, suggest that the occurrence of scintillations is mainly due to two types, namely the Plasma Bubble Induced (PBI, which maximizes during the post sunset hours of winter and equinoctial months, and the Bottom Side Sinusoidal (BSS type, which maximizes during the post-midnight hours of the summer solstice months. A detailed study on the spectral characteristics of the scintillations at both the frequencies show that the post-sunset scintillations are strong with fast fading (≈40 fad/min and are multiple in nature in scattering, giving rise to steep spectral slopes, whereas the post-midnight scintillations, which occur mostly on the VHF signal with low fading rate (≈4 fad/min, are of the BSS type, often showing typical Fresnel oscillations with reduced roll off spectral slopes, indicating that the type of irregularity resembles a thin screen structure giving rise to weak scattering. Using the onset times of several similar scintillation patches across the two satellite (FLEETSAT 73° E, INMARSAT 65° E ray paths (sub-ionospheric points are separated by 82 km, the East ward movement of the irregularity patches is found to vary from 150 to 250 m/s during the post sunset hours and decrease slowly during the post midnight hours. Further, the east-west extent of the PBI type of irregularities is found to vary from 100 to 500 km, while that of the BSS type extend up to a few thousand kilometers. Keywords. Ionosphere (Ionospheric irregularities; Auroral ionosphere; Electric fields and currents

  16. Alternative method for quantification of alfa-amylase activity Alternativa para quantificação de alfa-amilase

    OpenAIRE

    DF. Farias; AFU. Carvalho; CC. Oliveira; NM. Sousa; LCB. Rocha-Bezerrra; PMP. Ferreira; GPG. Lima; DC. Hissa

    2010-01-01

    A modification of the sensitive agar diffusion method was developed for macro-scale determination of alfa-amylase. The proposed modifications lower costs with the utilisation of starch as substrate and agar as supporting medium. Thus, a standard curve was built using alfa-amylase solution from Aspergillus oryzae, with concentrations ranging from 2.4 to 7,500 U.mL-1. Clear radial diffusion zones were measured after 4 hours of incubation at 20 °C. A linear relationship between the logarithm of...

  17. ALFA: The new ALICE-FAIR software framework

    Science.gov (United States)

    Al-Turany, M.; Buncic, P.; Hristov, P.; Kollegger, T.; Kouzinopoulos, C.; Lebedev, A.; Lindenstruth, V.; Manafov, A.; Richter, M.; Rybalchenko, A.; Vande Vyvre, P.; Winckler, N.

    2015-12-01

    The commonalities between the ALICE and FAIR experiments and their computing requirements led to the development of large parts of a common software framework in an experiment independent way. The FairRoot project has already shown the feasibility of such an approach for the FAIR experiments and extending it beyond FAIR to experiments at other facilities[1, 2]. The ALFA framework is a joint development between ALICE Online- Offline (O2) and FairRoot teams. ALFA is designed as a flexible, elastic system, which balances reliability and ease of development with performance using multi-processing and multithreading. A message- based approach has been adopted; such an approach will support the use of the software on different hardware platforms, including heterogeneous systems. Each process in ALFA assumes limited communication and reliance on other processes. Such a design will add horizontal scaling (multiple processes) to vertical scaling provided by multiple threads to meet computing and throughput demands. ALFA does not dictate any application protocols. Potentially, any content-based processor or any source can change the application protocol. The framework supports different serialization standards for data exchange between different hardware and software languages.

  18. New Synthesis of .alfa.,.omega.-Diiodoalkynes and Capped Iodobutadiynes

    Czech Academy of Sciences Publication Activity Database

    Hlavatý, Jaromír; Kavan, Ladislav; Štícha, M.

    - (2002), s. 705-706 ISSN 1472-7781 R&D Projects: GA ČR GA203/00/0634 Institutional research plan: CEZ:AV0Z4040901 Keywords : .alfa.,. omega .-diiodoalkynes * capped iodobutadiynes Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 2.181, year: 2002

  19. Carbonaceous Polymers and Nanotubes from .alfa., .omega.-Dialkali Hexatriynides

    Czech Academy of Sciences Publication Activity Database

    Hlavatý, Jaromír; Kavan, Ladislav; Okabe, K.; Oya, A.

    2002-01-01

    Roč. 40, č. 7 (2002), s. 1147-1150 ISSN 0008-6223 R&D Projects: GA ČR GA203/00/0634 Institutional research plan: CEZ:AV0Z4040901 Keywords : carbon nanotubes * chemically modified carbon * .alfa.,. omega .-dialkali hexatriynides Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 3.048, year: 2002

  20. Drotrecogin alfa (activated) in adults with septic shock.

    NARCIS (Netherlands)

    Ranieri, V.M.; Thompson, B.T.; Barie, P.S.; Dhainaut, J.F.; Douglas, I.S.; Finfer, S.; Gardlund, B.; Marshall, J.C.; Rhodes, A.; Artigas, A.; Payen, D.; Tenhunen, J.; Al-Khalidi, H.R.; Thompson, V.; Janes, J.; Macias, W.L.; Vangerow, B.; Williams, M.D.; Pickkers, P.; Raemaekers, J.M.; et al.,

    2012-01-01

    BACKGROUND: There have been conflicting reports on the efficacy of recombinant human activated protein C, or drotrecogin alfa (activated) (DrotAA), for the treatment of patients with septic shock. METHODS: In this randomized, double-blind, placebo-controlled, multicenter trial, we assigned 1697

  1. A New Approach to the ALFA Trigger Simulator

    CERN Document Server

    Dziedzic, Bartosz

    2016-01-01

    The idea and principle of operation of a device which is used to test the trigger system of the ALFA detectors of the ATLAS experiment at the LHC are discussed. A new approach to the application control is presented. The application runs under control of the ArchLinuxARM operating system. Also, the drawbacks of the new solution are discussed.

  2. Observations of 50/60 Hz Power Line Radiation in the Low Latitude Ionosphere Detected by the Electric Field Instrument on the C/NOFS Satellite

    Science.gov (United States)

    Pfaff, R. F., Jr.; Freudenreich, H. T.; Simoes, F. A.; Liebrecht, M. C.; Farrell, W.

    2017-12-01

    One of the most ubiquitous forms of EM radiation emanating from the earth's surface is that of power line radiation. Associated with AC electric power generation, such emissions are typically launched along conducting power lines that may travel hundreds, or even thousands of km, from generating stations. The fundamental frequencies of such emissions are characteristically 50 Hz or 60 Hz, depending on the regional standards for power generation/consumption. The frequency of this radiation is well below that of the plasma frequency of the ionosphere (typically several MHz) and hence is expected to reflect back to the earth and propagate in the waveguide formed by the earth's surface and the bottom ledge of the ionosphere, typically near 100 km. Given that such power lines are widespread on the exposed lithosphere, the leakage of some ELF emissions associated with electric power generation might nevertheless be expected in the ionosphere, in the same manner in which a small fraction of the power associated with ELF Schumann resonances and lightning sferics have been shown to penetrate into the ionosphere. We present direct measurements of 50/60 Hz power line radiation detected by in situ probes on an orbiting satellite in the earth's ionosphere. The data were gathered by the Vector Electric Field Investigation (VEFI) tri-axial double probe detector flown on the Communication/Navigation Outage Forecast System (C/NOFS) satellite. C/NOFS was launched in April, 2008 into a low latitude (13 deg inclination) orbit with perigee and apogee of 400 km and 850 km, respectively. The electric field wave data were gathered by ELF receivers comprised of two orthogonal broadband channels sampled at 512 s/sec each, and digitized with 16 bit A/D converters. The data show distinct 60 Hz emissions while the satellite sampled within the Brazilian sector whereas distinct 50 Hz emissions were detected over India. Other, less distinct, emissions were observed over Africa and southeast Asia

  3. Pathophysiology of hypophosphatasia and the potential role of asfotase alfa

    Directory of Open Access Journals (Sweden)

    Orimo H

    2016-05-01

    Full Text Available Hideo Orimo Division of Metabolism and Nutrition, Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan Abstract: Hypophosphatasia (HPP is an inherited systemic bone disease that is characterized by bone hypomineralization. HPP is classified into six forms according to the age of onset and severity as perinatal (lethal, perinatal benign, infantile, childhood, adult, and odontohypophosphatasia. The causative gene of the disease is the ALPL gene that encodes tissue-nonspecific alkaline phosphatase (TNAP. TNAP is expressed ubiquitously, and its physiological role is apparent in bone mineralization. A defect in bone mineralization can manifest in several ways, including rickets or osteomalacia in HPP patients. Patients with severe forms suffer from respiratory failure because of hypoplastic chest, which is the main cause of death. They sometimes present with seizures due to a defect in vitamin B6 metabolism resulting from the lack of alkaline phosphatase activity in neuronal cells, which is also lethal. Patients with a mild form of the disease exhibit rickets or osteomalacia and a functional defect of exercise. Odontohypophosphatasia shows only dental manifestations. To date, 302 mutations in the ALPL gene have been reported, mainly single-nucleotide substitutions, and the relationships between phenotype and genotype have been partially elucidated. An established treatment for HPP was not available until the recent development of enzyme replacement therapy. The first successful enzyme replacement therapy in model mice using a modified human TNAP protein (asfotase alfa was reported in 2008, and subsequently success in patients with severe form of the disease was reported in 2012. In 2015, asfotase alfa was approved in Japan in July, followed by in the EU and Canada in August, and then by the US Food and Drug Administration in the USA in October. It is expected that therapy with asfotase alfa will drastically change

  4. Upgrade of ATLAS-ALFA for Run2

    CERN Document Server

    Jakobsen, Sune; The ATLAS collaboration

    2016-01-01

    Early experience with the operation of the ALFA detectors in the LHC environment has shown significant beam-induced heating. Comprehensive studies on the effects of heating with a spare detector module have furthermore revealed that heating effects could be disastrous in the case of the larger beam intensities foreseen for higher luminosity. A temporary solution was implemented and kept the detectors below the critical temperature in 2012. In LS1 all ALFA stations have been removed from LHC and are undergoing an upgrade of the geometry of Roman Pots to minimize the impedance losses. When the stations were re-installed ~4 m distance was added between them to gain level arm in the angular measurement between the stations. The updated geometry of the Roman Pot, together with a system to improve the internal heat transfer and an air cooling system, is expected to keep the temperatures of ALFA detectors below critical limits throughout the LHC Run2 and first results from the performance in 2016 will be presented. ...

  5. Calibration, testing, commissioning and first data of ALFA at LHC

    CERN Document Server

    Jakobsen, S; The ATLAS collaboration

    2011-01-01

    The ALFA detector system (Absolute Luminosity For ATLAS) aims for measuring the absolute LHC luminosity with high precision by using pp-scattering under small angles. Scintillating fibers tracking detectors are positioned 240 m from LHC interaction point 1 inside Roman Pots at millimeter distance from the LHC beam axis. The detectors consist of layers of 64 scintillating square fibers of 500 µm size in a U-V configuration. The layers are staggered 10 times to improve the spatial resolution to about 30 micrometers. A total of 11680 scintillating fibers are read out on the 8 ALFA detectors through 184 Multi Anode Photomultiplier Tubes, MAPMTs, of type Hamamatsu R7600-00-M64, 64 channels. Each detector has dedicated scintillating trigger tiles read out by 8 mm Hamamatsu Photomultiplier Tubes (R7400P and R9880U-110) via clear fibers. The gain of the MAPMTs differs up to a factor 3 inside a MAPMT and an additional factor 2 between different MAPMTs. For compensation, ALFA has developed a front-end electronic based...

  6. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease

    DEFF Research Database (Denmark)

    Pfeffer, Marc A; Burdmann, Emmanuel A; Chen, Chao-Yin

    2009-01-01

    BACKGROUND: Anemia is associated with an increased risk of cardiovascular and renal events among patients with type 2 diabetes and chronic kidney disease. Although darbepoetin alfa can effectively increase hemoglobin levels, its effect on clinical outcomes in these patients has not been adequately...... tested. METHODS: In this study involving 4038 patients with diabetes, chronic kidney disease, and anemia, we randomly assigned 2012 patients to darbepoetin alfa to achieve a hemoglobin level of approximately 13 g per deciliter and 2026 patients to placebo, with rescue darbepoetin alfa when the hemoglobin...... assigned to darbepoetin alfa and 496 patients assigned to placebo (Pchronic kidney disease...

  7. Validation of measured poleward TEC gradient using multi-station GPS with Artificial Neural Network based TEC model in low latitude region for developing predictive capability of ionospheric scintillation

    Science.gov (United States)

    Sur, D.; Paul, A.

    2017-12-01

    The equatorial ionosphere shows sharp diurnal and latitudinal Total Electron Content (TEC) variations over a major part of the day. Equatorial ionosphere also exhibits intense post-sunset ionospheric irregularities. Accurate prediction of TEC in these low latitudes is not possible from standard ionospheric models. An Artificial Neural Network (ANN) based Vertical TEC (VTEC) model has been designed using TEC data in low latitude Indian longitude sector for accurate prediction of VTEC. GPS TEC data from the stations Calcutta (22.58°N, 88.38°E geographic, magnetic dip 32°), Baharampore (24.09°N, 88.25°E geographic, magnetic dip 35°) and Siliguri (26.72°N, 88.39°E geographic; magnetic dip 40°) are used as training dataset for the duration of January 2007-September 2011. Poleward VTEC gradients from northern EIA crest to region beyond EIA crest have been calculated from measured VTEC and compared with that obtained from ANN based VTEC model. TEC data from Calcutta and Siliguri are used to compute VTEC gradients during April 2013 and August-September 2013. It has been observed that poleward VTEC gradient computed from ANN based TEC model has shown good correlation with measured values during vernal and autumnal equinoxes of high solar activity periods of 2013. Possible correlation between measured poleward TEC gradients and post-sunset scintillations (S4 ≥ 0.4) from northern crest of EIA has been observed in this paper. From the observation, a suitable threshold poleward VTEC gradient has been proposed for possible occurrence of post-sunset scintillations at northern crest of EIA along 88°E longitude. Poleward VTEC gradients obtained from ANN based VTEC model are used to forecast possible ionospheric scintillation after post-sunset period using the threshold value. It has been observed that these predicted VTEC gradients obtained from ANN based VTEC model can forecast post-sunset L-band scintillation with an accuracy of 67% to 82% in this dynamic low latitude

  8. Adoption and de-adoption of drotrecogin alfa for severe sepsis in the United States.

    Science.gov (United States)

    Kahn, Jeremy M; Le, Tri Q

    2016-04-01

    Drotrecogin alfa was a landmark drug for treatment of severe sepsis, yet little is known about how it was adopted and de-adopted during its 10-year period of availability. We used hospitalization data on fee-for-service Medicare beneficiaries from 2002 to 2011 to characterize trends in the use of drotrecogin alfa in the United States. Drotrecogin alfa use peaked at 5.87 per 1000 severe sepsis hospitalizations in 2003 and then steadily declined to 0.94 administrations per 1000 severe sepsis hospitalizations in 2010. Large teaching hospitals were more likely to use drotrecogin alfa than small, nonteaching hospitals. The addition of "add-on payments" to hospitals for using drotrecogin alfa in 2002 was associated with significantly increased use (P publication of international sepsis guidelines with favorable drotrecogin alfa recommendations (in 2004 and 2008) nor the publication of a clinical trial focused on drotrecogin alfa (in 2005) were associated with consistent changes use (P > .05). Drotrecogin alfa use declined over time, with marked changes in use associated with drug-specific financial incentives but not the publication of clinical practice guidelines or clinical trials. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. Pathophysiology of hypophosphatasia and the potential role of asfotase alfa.

    Science.gov (United States)

    Orimo, Hideo

    2016-01-01

    Hypophosphatasia (HPP) is an inherited systemic bone disease that is characterized by bone hypomineralization. HPP is classified into six forms according to the age of onset and severity as perinatal (lethal), perinatal benign, infantile, childhood, adult, and odontohypophosphatasia. The causative gene of the disease is the ALPL gene that encodes tissue-nonspecific alkaline phosphatase (TNAP). TNAP is expressed ubiquitously, and its physiological role is apparent in bone mineralization. A defect in bone mineralization can manifest in several ways, including rickets or osteomalacia in HPP patients. Patients with severe forms suffer from respiratory failure because of hypoplastic chest, which is the main cause of death. They sometimes present with seizures due to a defect in vitamin B6 metabolism resulting from the lack of alkaline phosphatase activity in neuronal cells, which is also lethal. Patients with a mild form of the disease exhibit rickets or osteomalacia and a functional defect of exercise. Odontohypophosphatasia shows only dental manifestations. To date, 302 mutations in the ALPL gene have been reported, mainly single-nucleotide substitutions, and the relationships between phenotype and genotype have been partially elucidated. An established treatment for HPP was not available until the recent development of enzyme replacement therapy. The first successful enzyme replacement therapy in model mice using a modified human TNAP protein (asfotase alfa) was reported in 2008, and subsequently success in patients with severe form of the disease was reported in 2012. In 2015, asfotase alfa was approved in Japan in July, followed by in the EU and Canada in August, and then by the US Food and Drug Administration in the USA in October. It is expected that therapy with asfotase alfa will drastically change treatments and prognosis of HPP.

  10. ALFA detector, Background removal and analysis for elastic events

    CERN Document Server

    Belaloui, Nazim

    2017-01-01

    I worked on the ALFA project, which has the aim to measure the total cross section in PP collisions as a function of t, the momentum transfer by measuring the scattering angle of the protons. This measurement is done for all available energies; so far 7, 8 and 13 TeV. There are many analysis steps and we have focused on enhancing the signal-to-noise ratio. First of all I tried to be more familiar with ROOT, worked on understanding the code used to access to the data, plotting histograms, then cutting-off background.

  11. Alternative method for quantification of alfa-amylase activity Alternativa para quantificação de alfa-amilase

    Directory of Open Access Journals (Sweden)

    DF. Farias

    2010-05-01

    Full Text Available A modification of the sensitive agar diffusion method was developed for macro-scale determination of alfa-amylase. The proposed modifications lower costs with the utilisation of starch as substrate and agar as supporting medium. Thus, a standard curve was built using alfa-amylase solution from Aspergillus oryzae, with concentrations ranging from 2.4 to 7,500 U.mL-1. Clear radial diffusion zones were measured after 4 hours of incubation at 20 °C. A linear relationship between the logarithm of enzyme activities and the area of clear zones was obtained. The method was validated by testing α-amylase from barley at the concentrations of 2.4; 60; 300 and 1,500 U.mL-1. The proposed method turned out to be simpler, faster, less expensive and able to determine on a macro-scale α-amylase over a wide range (2.4 to 7,500 U.mL-1 in scientific investigation as well as in teaching laboratory activities.Modificações foram propostas ao método sensível de difusão em ágar para a macrodeterminação de alfa-amilase. As modificações propostas diminuem os custos, com a utilização de amido como substrato e ágar como meio solidificante. Assim, foi construída uma curva padrão utilizando uma solução de alfa-amilase de Aspergillus oryzae com concentrações variando de 2,4 a 7.500 U.mL-1. Em seguida, as zonas claras de difusão radial foram mensuradas depois de 4 horas de incubação a 20 °C. Foi obtida uma relação linear entre o logaritmo da atividade enzimática e os diâmetros das zonas claras. O método foi validado utilizando-se soluções de alfa-amilase de cevada nas concentrações de 2,4; 60; 300 e 1.500 U.mL-1. O método tornou-se mais simples, rápido, com baixo custo e passível de ser utilizado para macrodeterminação de alfa-amilase em ampla faixa (2,4 a 7.500 U.mL-1 na investigação científica e para fins didáticos em aulas práticas.

  12. Alternative method for quantification of alfa-amylase activity.

    Science.gov (United States)

    Farias, D F; Carvalho, A F U; Oliveira, C C; Sousa, N M; Rocha-Bezerrra, L C B; Ferreira, P M P; Lima, G P G; Hissa, D C

    2010-05-01

    A modification of the sensitive agar diffusion method was developed for macro-scale determination of alfa-amylase. The proposed modifications lower costs with the utilisation of starch as substrate and agar as supporting medium. Thus, a standard curve was built using alfa-amylase solution from Aspergillus oryzae, with concentrations ranging from 2.4 to 7,500 U.mL-1. Clear radial diffusion zones were measured after 4 hours of incubation at 20 A degrees C. A linear relationship between the logarithm of enzyme activities and the area of clear zones was obtained. The method was validated by testing alpha-amylase from barley at the concentrations of 2.4; 60; 300 and 1,500 U.mL-1. The proposed method turned out to be simpler, faster, less expensive and able to determine on a macro-scale alpha-amylase over a wide range (2.4 to 7,500 U.mL-1) in scientific investigation as well as in teaching laboratory activities.

  13. Alfa-Laval plate heat exchangers for the power industries

    International Nuclear Information System (INIS)

    Kitae, Junnosuke; Mtsuura, Kazuyuki

    1979-01-01

    Within power-generating plants, the transfer and conversion of heat energy of very large quantity are carried out in the process of energy conversion, accordingly the importance of heat exchangers is very high. Heretofore, multi-tube heat exchangers have been used mostly, but Alfa-Laval group developed the heat exchanger with very high efficiency to incorporate it effectively into a power-generating plant. In this plate type heat exchanger, the heat transfer efficiency is very high, and the quantity of stagnation is small as it is compact, consequently it is suitable to the secondary cooling for power-generating plant or the heat exchange of high-priced liquid heat media such as heavy water. Originally, plate type heat exchangers were used for food and chemical industries, therefore the prevention of mixing two liquids, sanitary construction, and corrosion resistance were required. Then they were adopted in iron and steel industry, and large thermal load, large heat transfer area and corrosion resistance to sea water were required. They were adopted in a nuclear power plant for the first time in 1964. In this heat exchanger, channels are formed with corrugated metal sheets, and titanium, stainless steels, Incoloy, Hastelloy and others are used as occasion demands. The Alfa-Laval heat exchangers and their features are explained. (Kako, I.)

  14. Alternative method for quantification of alfa-amylase activity

    Directory of Open Access Journals (Sweden)

    DF. Farias

    Full Text Available A modification of the sensitive agar diffusion method was developed for macro-scale determination of alfa-amylase. The proposed modifications lower costs with the utilisation of starch as substrate and agar as supporting medium. Thus, a standard curve was built using alfa-amylase solution from Aspergillus oryzae, with concentrations ranging from 2.4 to 7,500 U.mL-1. Clear radial diffusion zones were measured after 4 hours of incubation at 20 °C. A linear relationship between the logarithm of enzyme activities and the area of clear zones was obtained. The method was validated by testing α-amylase from barley at the concentrations of 2.4; 60; 300 and 1,500 U.mL-1. The proposed method turned out to be simpler, faster, less expensive and able to determine on a macro-scale α-amylase over a wide range (2.4 to 7,500 U.mL-1 in scientific investigation as well as in teaching laboratory activities.

  15. Assessment of Relative Bioavailability of Moroctocog Alfa and Moroctocog Alfa (AF-CC) in Subjects With Severe Hemophilia A.

    Science.gov (United States)

    Korth-Bradley, Joan; Rupon, Jeremy; Plotka, Anna; Charnigo, Robert; Rendo, Pablo

    2018-05-01

    An open-label, single-dose, randomized, two-period, crossover study comparing the pharmacokinetics of factor VIII activity in plasma (FVIII:C) after administration of an albumin-free presentation of moroctocog alfa (test) and moroctocog alfa manufactured using the previous technique (reference) was conducted in 30 (25 evaluable) male subjects who had severe hemophilia A (FVIII:C < 1 IU/dL). Blood samples were collected for 48 h after administration of each dose. C was assayed using a chromogenic substrate assay. The FVIII:C pharmacokinetic parameters were calculated using noncompartmental analysis. The presentations would be bioequivalent if the 90% confidence limits of the ratio of the geometric mean values of AUC inf and recovery fell within the interval of 80-125%. The bioequivalence criteria were met. A total of 10 treatment-related adverse events were observed in a total of nine subjects. All were mild and none was determined to be related to administration of study medication. © 2018 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

  16. Evaluating the transport layer of the ALFA framework for the Intel® Xeon Phi™ Coprocessor

    Science.gov (United States)

    Santogidis, Aram; Hirstius, Andreas; Lalis, Spyros

    2015-12-01

    The ALFA framework supports the software development of major High Energy Physics experiments. As part of our research effort to optimize the transport layer of ALFA, we focus on profiling its data transfer performance for inter-node communication on the Intel Xeon Phi Coprocessor. In this article we present the collected performance measurements with the related analysis of the results. The optimization opportunities that are discovered, help us to formulate the future plans of enabling high performance data transfer for ALFA on the Intel Xeon Phi architecture.

  17. Experimental investigation of the mechanical properties of Alfas stone

    Directory of Open Access Journals (Sweden)

    Konstas N. Kaklis

    2017-04-01

    Full Text Available This paper focuses on the experimental investigation of the mechanical properties of the Alfas natural building stone. Two series of uniaxial compression tests and indirect tensile tests (Brazilian tests were performed in order to determine the uniaxial compressive strength and the indirect tensile strength respectively. Different sets of cylindrical specimens and circular discs were prepared by varying their geometry in order to examine the size effect on the respective strength values. Also, the size effect was investigated with respect to the calculated intact rock modulus and Poisson’s ratio. All specimens were prepared by following the ISRM suggested methods and the load was applied using a stiff 1600 kN MTS hydraulic testing machine and a 500 kN load cell. Strain was measured using biaxial 0/90 stacked rosettes appropriately attached on each specimen.

  18. Fast radio burst discovered in the Arecibo pulsar ALFA survey

    International Nuclear Information System (INIS)

    Spitler, L. G.; Freire, P. C. C.; Lazarus, P.; Lee, K. J.; Cordes, J. M.; Chatterjee, S.; Wharton, R. S.; Brazier, A.; Hessels, J. W. T.; Lorimer, D. R.; McLaughlin, M. A.; Crawford, F.; Deneva, J. S.; Kaspi, V. M.; Karako-Argaman, C.; Allen, B.; Bogdanov, S.; Camilo, F.; Jenet, F. A.; Knispel, B.

    2014-01-01

    Recent work has exploited pulsar survey data to identify temporally isolated, millisecond-duration radio bursts with large dispersion measures (DMs). These bursts have been interpreted as arising from a population of extragalactic sources, in which case they would provide unprecedented opportunities for probing the intergalactic medium; they may also be linked to new source classes. Until now, however, all so-called fast radio bursts (FRBs) have been detected with the Parkes radio telescope and its 13-beam receiver, casting some concern about the astrophysical nature of these signals. Here we present FRB 121102, the first FRB discovery from a geographic location other than Parkes. FRB 121102 was found in the Galactic anti-center region in the 1.4 GHz Pulsar Arecibo L-band Feed Array (ALFA) survey with the Arecibo Observatory with a DM = 557.4 ± 2.0 pc cm –3 , pulse width of 3.0 ± 0.5 ms, and no evidence of interstellar scattering. The observed delay of the signal arrival time with frequency agrees precisely with the expectation of dispersion through an ionized medium. Despite its low Galactic latitude (b = –0.°2), the burst has three times the maximum Galactic DM expected along this particular line of sight, suggesting an extragalactic origin. A peculiar aspect of the signal is an inverted spectrum; we interpret this as a consequence of being detected in a sidelobe of the ALFA receiver. FRB 121102's brightness, duration, and the inferred event rate are all consistent with the properties of the previously detected Parkes bursts.

  19. Fast radio burst discovered in the Arecibo pulsar ALFA survey

    Energy Technology Data Exchange (ETDEWEB)

    Spitler, L. G.; Freire, P. C. C.; Lazarus, P.; Lee, K. J. [Max-Planck-Institut für Radioastronomie, D-53121 Bonn (Germany); Cordes, J. M.; Chatterjee, S.; Wharton, R. S.; Brazier, A. [Department of Astronomy and Space Sciences, Cornell University, Ithaca, NY 14853 (United States); Hessels, J. W. T. [ASTRON, Netherlands Institute for Radio Astronomy, Postbus 2, 7990 AA, Dwingeloo (Netherlands); Lorimer, D. R.; McLaughlin, M. A. [Department of Physics and Astronomy, West Virginia University, Morgantown, WV 26506 (United States); Crawford, F. [Department of Physics and Astronomy, Franklin and Marshall College, Lancaster, PA 17604-3003 (United States); Deneva, J. S. [Naval Research Laboratory, 4555 Overlook Ave SW, Washington, DC 20375 (United States); Kaspi, V. M.; Karako-Argaman, C. [Department of Physics, McGill University, Montreal, QC H3A 2T8 (Canada); Allen, B. [Physics Department, University of Wisconsin-Milwaukee, Milwaukee, WI 53211 (United States); Bogdanov, S.; Camilo, F. [Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027 (United States); Jenet, F. A. [Center for Gravitational Wave Astronomy, University of Texas at Brownsville, Brownsville, TX 78520 (United States); Knispel, B., E-mail: lspitler@mpifr-bonn.mpg.de [Leibniz Universität, Hannover, D-30167 Hannover (Germany); and others

    2014-08-01

    Recent work has exploited pulsar survey data to identify temporally isolated, millisecond-duration radio bursts with large dispersion measures (DMs). These bursts have been interpreted as arising from a population of extragalactic sources, in which case they would provide unprecedented opportunities for probing the intergalactic medium; they may also be linked to new source classes. Until now, however, all so-called fast radio bursts (FRBs) have been detected with the Parkes radio telescope and its 13-beam receiver, casting some concern about the astrophysical nature of these signals. Here we present FRB 121102, the first FRB discovery from a geographic location other than Parkes. FRB 121102 was found in the Galactic anti-center region in the 1.4 GHz Pulsar Arecibo L-band Feed Array (ALFA) survey with the Arecibo Observatory with a DM = 557.4 ± 2.0 pc cm{sup –3}, pulse width of 3.0 ± 0.5 ms, and no evidence of interstellar scattering. The observed delay of the signal arrival time with frequency agrees precisely with the expectation of dispersion through an ionized medium. Despite its low Galactic latitude (b = –0.°2), the burst has three times the maximum Galactic DM expected along this particular line of sight, suggesting an extragalactic origin. A peculiar aspect of the signal is an inverted spectrum; we interpret this as a consequence of being detected in a sidelobe of the ALFA receiver. FRB 121102's brightness, duration, and the inferred event rate are all consistent with the properties of the previously detected Parkes bursts.

  20. Alfa tahab TeliaSonerat Türgis üle pakkuda / Tõnis Arnover

    Index Scriptorium Estoniae

    Arnover, Tõnis, 1952-

    2005-01-01

    TeliaSoneraga, kellele kuulub 37 protsenti Türgi operaatorfirma Turkcell aktsiatest, konkureerib täiendava 27 protsendise aktsiapaki ostmises Venemaa operaatorfirmaga Alfa Telecom. Lisa: Kaasosanike huvid põrkuvad. Diagramm: Konkurendid Vene MegaFonis

  1. Measurement of the total cross section with ALFA Detector at ATLAS

    CERN Document Server

    Trzebinski, M; The ATLAS collaboration

    2017-01-01

    The main goals of the Absolute Luminosity For ATLAS (ALFA) detector is to provide an absolute luminosity and total cross section measurement. The measurement method used, the detector alignment and the quality of the collected data are discussed.

  2. Towards a Total Cross Section Measurement with the ALFA Detector at ATLAS

    CERN Document Server

    Trzebiński, Maciej

    2013-01-01

    The main goals of the Absolute Luminosity For ATLAS (ALFA) detector is to provide an absolute luminosity and total cross section measurement. The measurement method used, the detector alignment and the quality of the collected data are discussed.

  3. Role of neutral wind and storm time electric fields inferred from the storm time ionization distribution at low latitudes: in-situ measurements by Indian satellite SROSS-C2

    Directory of Open Access Journals (Sweden)

    P. Subrahmanyam

    2005-11-01

    Full Text Available Recently, there has been a renewal of interest in the study of the effects of solar weather events on the ionization redistribution and irregularity generation. The observed changes at low and equatorial latitudes are rather complex and are noted to be a function of location, the time of the storm onset and its intensity, and various other characteristics of the geomagnetic storms triggered by solar weather events. At these latitudes, the effects of geomagnetic storms are basically due to (a direct penetration of the magnetospheric electric fields to low latitudes, (b development of disturbance dynamo, (c changes in atmospheric neutral winds at ionospheric level and (d changes in neutral composition triggered by the storm time atmospheric heating.

    In the present study an attempt is made to further understand some of the observed storm time effects in terms of storm time changes in zonal electric fields and meridional neutral winds. For this purpose, observations made by the Retarding Potential Analyzer (RPA payload on board the Indian satellite SROSS-C2 are examined for four prominent geomagnetic storm events that occurred during the high solar activity period of 1997-2000. Available simultaneous observations, from the GPS satellite network, are also used. The daytime passes of SROSS-C2 have been selected to examine the redistribution of ionization in the equatorial ionization anomaly (EIA region. In general, EIA is observed to be weakened 12-24 h after the main phase onset (MPO of the storm. The storm time behaviour inferred by SROSS-C2 and the GPS satellite network during the geomagnetic storm of 13 November 1998, for which simultaneous observations are available, is found to be consistent. Storm time changes in the delay of received GPS signals are noted to be ~1-3 m, which is a significant component of the total delay observed on a quiet day.

    An attempt is made to identify and

  4. The inland boundary layer at low latitudes

    Science.gov (United States)

    Garratt, J. R.

    1985-08-01

    Observations from the Koorin boundary-layer experiment in Australia (latitude 16 °S) were analysed in a study of the nocturnal jet development. For geostrophic winds in the range 10 20 m s-1, ageostrophic wind magnitudes of 5 10m s-1 were common above the surface layer near sunset, with cross-isobar flow angles of about 40 °. The jet that then developed by midnight was probably the result of these large ageostrophic winds, strong surface cooling and favourable baroclinity and sloping terrain. The analysis is supported by numerical model calculations with special emphasis on the role of long-wave radiative cooling on turbulent decay. Decay is rapid in the presence of radiation, although there is little influence on stress divergence levels. Evidence of sea-breeze influences on the jet evolution, and on features of deeply penetrating sea breezes in general, will be presented and discussed in part 2 of this study (submitted to Boundary-Layer Meteorol.).

  5. Low-Latitude Ethane Rain on Titan

    Science.gov (United States)

    Dalba, Paul A.; Buratti, Bonnie J.; Brown, R. H.; Barnes, J. W.; Baines, K. H.; Sotin, C.; Clark, R. N.; Lawrence, K. J.; Nicholson, P. D.

    2012-01-01

    Cassini ISS observed multiple widespread changes in surface brightness in Titan's equatorial regions over the past three years. These brightness variations are attributed to rainfall from cloud systems that appear to form seasonally. Determining the composition of this rainfall is an important step in understanding the "methanological" cycle on Titan. I use data from Cassini VIMS to complete a spectroscopic investigation of multiple rain-wetted areas. I compute "before-and-after" spectral ratios of any areas that show either deposition or evaporation of rain. By comparing these spectral ratios to a model of liquid ethane, I find that the rain is most likely composed of liquid ethane. The spectrum of liquid ethane contains multiple absorption features that fall within the 2-micron and 5-micron spectral windows in Titan's atmosphere. I show that these features are visible in the spectra taken of Titan's surface and that they are characteristically different than those in the spectrum of liquid methane. Furthermore, just as ISS saw the surface brightness reverting to its original state after a period of time, I show that VIMS observations of later flybys show the surface composition in different stages of returning to its initial form.

  6. Low Latitude Aeronomy Study in Africa

    Science.gov (United States)

    2016-02-09

    was acquired and an aluminum base plate was attached to the optical dome for mounting on the top of the house for the instrument. The dome was...Preparation in Ivory Coast NCAR also worked closely with our Ivory Coast colleagues to make the necessary preparation for the site. An optical dome ...constructed a new hut to house the FPI with their funding (Figure 2). Figure 2. The hut (under construction earlier in 2015) in Korhogo Ivory

  7. Forward Detectors in ATLAS: ALFA, ZDC and LUCID

    CERN Document Server

    Fabbri, L; The ATLAS collaboration

    2009-01-01

    In order to determine the experimental cross sections for the observed physics processes, an estimation of the absolute luminosity is needed. In fact a careful study of “well known” processes will be one of the first steps of the LHC experiments as it can provide possible signatures of new physics which consist in deviations with respect to the Standard Model (SM) predictions. The methodologies for luminosity monitoring and total cross section estimation at the LHC will be reviewed in this talk along with the dedicated detectors of the ATLAS experiment. ATLAS will make extensive usage of the detectors in the forward region each one with a different task: LUCID (LUminosity measurement using Cherenkov Integrating Detector) is a system of 40 (2 x 20) Cherenkov tubes, surrounding the beam pipe at about 17 m from the interaction region. It will be able to monitor the collision-by-collision luminosity by detecting and counting the number of charged particles coming from the impact point. ALFA (Absolute Luminosi...

  8. Influence of anthropogenic activities on PAHs in sediments in a significant gulf of low-latitude developing regions, the Beibu Gulf, South China Sea: distribution, sources, inventory and probability risk.

    Science.gov (United States)

    Li, Pingyang; Xue, Rui; Wang, Yinghui; Zhang, Ruijie; Zhang, Gan

    2015-01-15

    Fifteen polycyclic aromatic hydrocarbons (PAHs) in 41 surface sediment samples and a sediment core (50 cm) from the Beibu Gulf, a significant low-latitude developing gulf, were analyzed. PAHs concentrations were 3.01-388 ng g(-)(1) (mean 95.5 ng g(-)(1)) in the surface sediments and 10.5-87.1 ng g(-)(1) (average 41.1 ng g(-)(1)) in the sediment core. Source apportionment indicated that PAHs were generated from coke production and vehicular emissions (39.4%), coal and biomass combustion (35.8%), and petrogenic sources (24.8%). PAHs were mainly concentrated in the industrialized and urbanized regions and the harbor, and were transported by atmospheric deposition to the marine matrix. The mass inventory (1.57-2.62t) and probability risk showed sediments here served as an important reservoir but low PAH risk. Different from oil and natural gas in developed regions, coal combustion has always been a significant energy consumption pattern in this developing region for the past 30 years (56 ± 5%). Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Collaborative study for the validation of an improved HPLC assay for recombinant IFN-alfa-2.

    Science.gov (United States)

    Jönsson, K H; Daas, A; Buchheit, K H; Terao, E

    2016-01-01

    The current European Pharmacopoeia (Ph. Eur.) texts for Interferon (IFN)-alfa-2 include a nonspecific photometric protein assay using albumin as calibrator and a highly variable cell-based assay for the potency determination of the protective effects. A request was expressed by the Official Medicines Control Laboratories (OMCLs) for improved methods for the batch control of recombinant interferon alfa-2 bulk and market surveillance testing of finished products, including those formulated with Human Serum Albumin (HSA). A HPLC method was developed at the Medical Products Agency (MPA, Sweden) for the testing of IFN-alfa-2 products. An initial collaborative study run under the Biological Standardisation Programme (BSP; study code BSP039) revealed the need for minor changes to improve linearity of the calibration curves, assay reproducibility and robustness. The goal of the collaborative study, coded BSP071, was to transfer and further validate this improved HPLC method. Ten laboratories participated in the study. Four marketed IFN-alfa-2 preparations (one containing HSA) together with the Ph. Eur. Chemical Reference Substance (CRS) for IFN-alfa-2a and IFN-alfa-2b, and in-house reference standards from two manufacturers were used for the quantitative assay. The modified method was successfully transferred to all laboratories despite local variation in equipment. The resolution between the main and the oxidised forms of IFN-alfa-2 was improved compared to the results from the BSP039 study. The improved method even allowed partial resolution of an extra peak after the principal peak. Symmetry of the main IFN peak was acceptable for all samples in all laboratories. Calibration curves established with the Ph. Eur. IFN-alfa-2a and IFN-alfa-2b CRSs showed excellent linearity with intercepts close to the origin and coefficients of determination greater than 0.9995. Assay repeatability, intermediate precision and reproducibility varied with the tested sample within acceptable

  10. Possibilities of uranium recovering as by product of copper lixiviation solution in Salobo 3-Alfa-Carajas

    International Nuclear Information System (INIS)

    Hohn, H.; Ferraioli, R.N.M.

    1983-05-01

    Geochemical and geophysics regional surveys performed by Nuclebras in 'Carajas, Para' State, show several favourable areas for uranium prospecting, including the 'Salobo 3-Alfa' copper mine. Some studies for increasing the Knowledge of uranium quantity and proportion and for accompanying the pilot plant installation, aiming the uranium extraction during the cycel of ore treatment in 'Salobo 3-Alfa' mine are described [pt

  11. A comparative study of night-time enhancement of TEC at a low latitude station on storm and quiet nights including the local time, seasonal and solar activity dependence

    Directory of Open Access Journals (Sweden)

    K. Unnikrishnan

    Full Text Available The main characteristics of night-time enhancements in TEC during magnetic storms are compared with those during quiet nights for different seasons and solar activity conditions at Palehua, a low latitude station during the period 1980–1989. We find that the mean amplitude has both a seasonal and solar activity dependence: in winter, the values are higher for weak storms as compared to those during quiet nights and increase with an increase in solar activity. In summer, the mean amplitude values during weak storms and quiet nights are almost equal. But during equinox, the mean amplitude values for quiet nights are greater than those during weak storms. The mean half-amplitude duration is higher during weak storms as compared to that during quiet nights in summer. However, during winter and equinox, the durations are almost equal for both quiet and weak storm nights. For the mean half-amplitude duration, the quiet night values for all the seasons and equinoctial weak storm values increase with an increase in solar activity. The occurrence frequency (in percent of TEC enhancement during weak storms is greater than during quiet nights for all seasons. The mean amplitude, the mean half-amplitude duration and the occurrence frequency (in percent of TEC enhancement values are higher during major storms as compared to those during quiet nights. The above parameters have their highest values during pre-midnight hours. From the data analysed, this behaviour is true in the case of major storms also.

    Key words. Ionosphere (ionospheric disturbances; plasma convection Magnetospheric physics (storms and substorms

  12. Pilot study of dornase alfa (Pulmozyme) therapy for acquired ventilator-associated infection in preterm infants.

    Science.gov (United States)

    Scala, Melissa; Hoy, Deborah; Bautista, Maria; Palafoutas, Judith Jones; Abubakar, Kabir

    2017-06-01

    Evaluate the feasibility, safety, and efficacy of adjunctive treatment with dornase alfa in preterm patients with ventilator-associated pulmonary infection (VAPI) compared to standard care. We hypothesize that therapy with dornase alfa will be safe and well tolerated in the preterm population with no worsening of symptoms, oxygen requirement, or need for respiratory support. Prospective, randomized, blinded, pilot study comparing adjunctive treatment with dornase alfa to sham therapy. In addition to standard care, infants were randomized to receive dornase alfa 2.5 mg nebulized via endotracheal tube (ETT) every 12 hr for 7 days or sham therapy. ETT secretion gram stain and culture and chest X-ray (CXR) findings were evaluated. Respiratory support data were downloaded from the ventilator. Fourteen infants developed VAPI between 2012 and 2014; 11 enrolled in the study. Six received dornase alfa and five received sham therapy. Average gestational age at birth was 25 weeks and age at study entry was 31 days. There were no differences in demographics, ETT white blood cell count (WBC), CXR, or mean airway pressure (MAP) between the two groups. There was a trend towards decreased oxygen requirement (FiO2) in the treatment group that did not reach statistical significance. No side effects were observed in the treatment group. Treatment with dornase alfa is safe and treated infants had some improvement in FiO 2 requirement but no improvement in MAP. A larger randomized trial is needed to evaluate the efficacy of this therapy. Pediatr Pulmonol. 2017; 52:787-791. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  13. Oxygenation of a rodent adenocarcinoma is improved by darbepoetin alfa

    International Nuclear Information System (INIS)

    Kirkpatrick, J.P.; Snyder, S.A.; Zhao, Y.; Peltz, C.; Brizel, D.M.; Dewhirst, M.W.; Blackwell, K.L.

    2003-01-01

    Full text: Tumor hypoxia, particularly in anemia, increases the risk of distant metastases and decreases survival. However, the benefits of stimulating erythropoiesis to supraphysiological levels are unclear. This study examines the effect of darbepoetin alfa (DEPA) on tumor oxygenation and the response to therapeutic radiation (XRT) in rats with initially normal hematocrit. R3230 adenocarcinoma was transplanted into the flank of female Fisher 344 rats. Starting on Day 4 post transplant, the rats received DEPA 3 μg/kg or normal saline sc tiw. At 3 weeks post transplant, pO2 was measured and the tumor excised, or the tumor was irradiated. pO2 was determined using an optical microprobe. In histologic studies, rats were injected with pimonidazole prior to sacrifice, and the tumors excised and stained with an antibody to pimonidazole (PIMO). Extent/intensity of staining was assessed by 3 observers and averaged to yield an IHC score. Rats ± DEPA with tumors 7 -12mm diameter were randomised to receive 32 Gy in 4 bid doses or sham irradiation. Tumor diameters in the 4 groups (±DEPA x ±XRT, total n=41) were measured by calipers. Failure was defined by the tumor reaching 15mm in diameter and used to generate Kaplan-Meier curves. Hematocrit at transplant averaged 45% (n=104) versus 67% in the DEPA-treated rats (n=18, p<0.0001) and 44% in the control animals (n=21.) Median pO2 in the DEPA-treated rats vs. controls did not differ significantly (17 vs. 13 mm Hg, p=0.10.) However, the fraction of tumor pO2 measurements <10mm Hg in the DEPA-treated rats was lower (21% vs. 37%, p=0.046.) IHC score was also less in the DEPA group (p=0.03.) XRT significantly improved failure-free survival (p<0.0001.) While the addition of DEPA to either the XRT or control groups did not significantly increase survival, the trend in both cases favored the DEPA-treated groups. In this tumor, treatment with DEPA improves oxygenation. However, no significant enhancement in radioesponsiveness by DEPA

  14. Features of 3–7-day planetary-wave-type oscillations in F-layer vertical drift and equatorial spread F observed over two low-latitude stations in China

    Directory of Open Access Journals (Sweden)

    Z. Zhu

    2017-06-01

    characteristics. The results highlight the role of planetary-wave-type oscillations in the initiation and development of ESF in the Chinese low-latitude region.

  15. A remarkable sea-level drop and relevant biotic responses across the Guadalupian-Lopingian (Permian) boundary in low-latitude mid-Panthalassa: Irreversible changes recorded in accreted paleo-atoll limestones in Akasaka and Ishiyama, Japan

    Science.gov (United States)

    Kofukuda, Daisuke; Isozaki, Yukio; Igo, Hisayoshi

    2014-03-01

    , in accordance with the contemporary sea-level curve based on continental shelf records, indicates that a remarkable sea-level drop has occurred globally during the latest Capitanian. This further suggests that a cool climate likely has appeared even in the low-latitude domains in Panthalassa to cause the decline of the Middle Permian shallow-water protists/animals that adapted to warmer seawater. The Wuchiapingian biota first appeared immediately after this erosional episode, i.e., during the onset of warming after the G-LB.

  16. Inter-comparison of cosmogenic in-situ 3He, 21Ne and 36Cl at low latitude along an altitude transect on the SE slope of the Kilimanjaro volcano (3°S, Tanzania)

    Science.gov (United States)

    Schimmelpfennig, I.; Williams, A.; Pik, R.; Burnard, P.; Niedermann, S.; Finkel, R. C.; Benedetti, L.; Schneider, B.

    2010-12-01

    Because the intensity and energy spectrum of the cosmic ray flux is affected by atmospheric depth and geomagnetic-field strength, cosmogenic nuclide production rates increase considerably with altitude and to a lesser degree with latitude. The scaling methods used to account for spatial variability in production rates assume that all cosmogenic nuclides have the same altitude dependence. In this study we evaluate whether the production rates of cosmogenic 36Cl, 3He and 21Ne change differently with altitude, which is plausible due to the different energy-thresholds of their production reactions. If so, nuclide-specific scaling factors would be required. Concentrations of the three cosmogenic nuclides were determined in mafic phenocrysts over an altitude transect between 1000 and 4300 m at Kilimanjaro volcano (3° S). Altitude-dependence of relative production rates was assessed in two ways: by determination of concentration ratios and by calculation of apparent exposure age ratios for all nuclide pairs. The latter accounts for characteristics of 36Cl that the stable nuclides 3He and 21Ne do not possess (radioactive decay, high sensitivity to mineral composition and significant contributions from production reactions other than spallation). All ratios overlap within error over the entire transect, and altitudinal variation in relative production rates is not therefore evident. This suggests that nuclide-specific scaling factors are not required for the studied nuclides at this low latitude location. However, because previous studies [1,2] documented anomalous altitude-dependent variations of 3He production at mid-latitude sites, the effect of latitude on cross-calibrations should be further evaluated. We determined cosmogenic 21Ne/3He concentration ratios of 0.187 ± 0.010 in pyroxenes and 0.375 ± 0.015 in olivines, agreeing with those reported in previous studies. Despite the absence of independently determined ages for the studied lava surfaces, the consistency in

  17. Valorization of Tunisian alfa fibres and sumac tannins for the elaboration of biodegradable insulating panels

    Science.gov (United States)

    Saad, Houda; Charrier, Bertrand; Ayed, Naceur; Charrier-El-Bouhtoury, Fatima

    2017-10-01

    Alfa leaves are important renewable raw materials in Tunisia where they are used basically in handcrafts and paper industry. Sumac is also an abundant species in Tunisia known for its high tannin content and is basically used in traditional medicine. To valorize these natural resources, we studied, for the first time, the possibility of making insulating panels based on alfa fibres and sumac tannins based adhesive. Firstly, alfa leaves were treated with an alkali solution as it is one of the standard procedures commonly used in the paper industry to extract cellulosic fibres. Mercerization effects were studied by characterizing fibres thermal properties and fibres surface morphology. Secondly, the sumac tannin based resin was formulated and characterized. Finally, the insulating panel was elaborated and characterized by determining its thermal conductivity. The thermal gravimetric analysis results show improvement in the thermal stability of fibres after alkali treatment. Environmental Scanning Electron Microscopy showed changes on treated alfa surface which could promote the fibre-matrix adhesion. The reactivity of sumac tannins to formaldehyde test (Stiasny number) showed the possible use of sumac tannins in wood adhesive formulation. Thermomechanical analysis and strength analysis of sumac tannin/hexamin based resin highlighted acceptable bonding properties. The thermal conductivity measurement showed an average value equal to 0.110 W/m K. Contribution to the topical issue "Materials for Energy harvesting, conversion and storage II (ICOME 2016)", edited by Jean-Michel Nunzi, Rachid Bennacer and Mohammed El Ganaoui

  18. Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors

    NARCIS (Netherlands)

    Connolly, Stuart J.; Milling, Truman J.; Eikelboom, John W.; Gibson, C. Michael; Curnutte, John T.; Gold, Alex; Bronson, Michele D.; Lu, Genmin; Conley, Pamela B.; Verhamme, Peter; Schmidt, Jeannot; Middeldorp, Saskia; Cohen, Alexander T.; Beyer-Westendorf, Jan; Albaladejo, Pierre; Lopez-Sendon, Jose; Goodman, Shelly; Leeds, Janet; Wiens, Brian L.; Siegal, Deborah M.; Zotova, Elena; Meeks, Brandi; Nakamya, Juliet; Lim, W. Ting; Crowther, Mark; Connolly, S. C.; Crowther, M.; Eikelboom, J.; Gibson, M.; Milling, T. J.; Albaladejo, P.; Cohen, A.; Lopez-Sendon, J.; Schmidt, J.; Verhamme, P.; Beyer-Westendorf, J.; Wyse, D. G.; Garcia, D.; Prins, M. [=Martin H.; Nakamya, J.; Büller, H. R.; Mahaffey, K.; Alexander, J.; Demchuk, A.; Raskob, G.; Schulman, S.; Meeks, B.; Zotova, E.; Holadyk-Gris, I.; Coppens, M.

    2016-01-01

    Background Andexanet alfa (andexanet) is a recombinant modified human factor Xa decoy protein that has been shown to reverse the inhibition of factor Xa in healthy volunteers. Methods In this multicenter, prospective, open-label, single-group study, we evaluated 67 patients who had acute major

  19. The in vitro mucolytic effect of xylitol and dornase alfa on chronic rhinosinusitis mucus.

    Science.gov (United States)

    Hardcastle, Tim; Jain, Ravi; Radcliff, Fiona; Waldvogel-Thurlow, Sharon; Zoing, Melissa; Biswas, Kristi; Douglas, Richard

    2017-09-01

    The overproduction and stagnation of purulent mucus impair mucociliary clearance and exacerbate the symptoms of chronic rhinosinusitis (CRS). There is a clinical need for effective topical mucolytic agents to facilitate removal of mucus and improve postoperative outcomes. The effects of xylitol (5%) and dornase alfa (1 mg/mL) on mucus and mucus crusts were investigated. Viscoelasticity and viscosity of wet mucus derived from 30 CRS patients was measured with a plate rheometer. Postoperative dried mucus crust dissolution was measured by examining peripheral transparency, central transparency, and border definition of treated crust samples from 17 CRS patients. Xylitol and dornase alfa reduced wet mucus viscoelasticity at a frequency of 0.1 Hz significantly more than the saline control. Treatments also produced significantly lower viscosities than saline at a shear rate of 10 and 100 seconds -1 . Xylitol and dornase alfa significantly decreased mucus crust border definition relative to saline. Xylitol and dornase alfa may be efficacious mucolytics, encouraging the breakdown of postoperative mucus crusts and the reduction of viscoelasticity and viscosity of wet mucus. In vivo study is required to evaluate the potential of these agents in treating recalcitrant CRS. © 2017 ARS-AAOA, LLC.

  20. Dynamic behavior of reactive aluminum nanoparticle-fluorinated acrylic (AlFA) polymer composites

    Science.gov (United States)

    Crouse, Christopher A.; White, Brad; Spowart, Jonathan E.

    2011-06-01

    The dynamic behavior of aluminum nanoparticle-fluorinated acrylic (AlFA) composite materials has been explored under high strain rates. Cylindrical pellets of the AlFA composite materials were mounted onto copper sabots and impacted against a rigid anvil at velocities between 100 and 400 m/s utilizing a Taylor gas gun apparatus to achieve strain rates on the order of 104 /s. A framing camera was used to record the compaction and reaction events that occurred upon contact of the pellet with the anvil. Under both open air and vacuum environments the AlFA composites demonstrated high reactivity suggesting that the particles are primarily reacting with the fluorinated matrix. We hypothesize, based upon the compaction history of these materials, that reaction is initiated when the oxide shells on the aluminum nanoparticles are broken due an interparticle contact deformation process. We have investigated this hypothesis through altering the particle loading in the AlFA composites as well as impact velocities. This data and the corresponding trends will be presented in detail.

  1. Arecibo pulsar survey using ALFA: probing radio pulsar intermittency and transients

    NARCIS (Netherlands)

    Deneva, J.S.; Cordes, J.M.; McLaughlin, M.A.; Nice, D.J.; Lorimer, D.R.; Crawford, F.; Bhat, N.D.R.; Camilo, F.; Champion, D.J.; Freire, P.C.C.; Edel, S.; Kondratiev, V.I.; Hessels, J.W.T.; Jenet, F.A.; Kasian, L.; Kaspi, V.M.; Kramer, M.; Lazarus, P.; Ransom, S.M.; Stairs, I.H.; Stappers, B.W.; van Leeuwen, J.; Brazier, A.; Venkataraman, A.; Zollweg, J.A.; Bogdanov, S.

    2009-01-01

    We present radio transient search algorithms, results, and statistics from the ongoing Arecibo Pulsar ALFA (PALFA) survey of the Galactic plane. We have discovered seven objects through a search for isolated dispersed pulses. All of these objects are Galactic and have measured periods between 0.4

  2. Fluorouracil continuous infusion plus alfa interferon plus oral folinic acid in advanced colorectal cancer

    NARCIS (Netherlands)

    Punt, C. J.; de Mulder, P. H.; Burghouts, J. T.; Wagener, D. J.

    1992-01-01

    Several reports on fluorouracil (5-FU) and alfa interferon (IFN-alpha) combination therapy in patients with advanced colorectal cancer have been published. In our study high-dose continuous infusion 5-FU (60 mg/kg per 48 hours), oral folinic acid (FA) (8 x 90 mg during 5-FU), and IFN-alpha three

  3. Antiviral activity of telaprevir (VX-950) and peginterferon alfa-2a in patients with hepatitis C

    NARCIS (Netherlands)

    Forestier, Nicole; Reesink, Hendrik W.; Weegink, Christine J.; McNair, Lindsay; Kieffer, Tara L.; Chu, Hui-May; Purdy, Susan; Jansen, Peter L. M.; Zeuzem, Stefan

    2007-01-01

    Telaprevir (VX-950), an inhibitor of the hepatitis C virus (HCV) NS3/4A protease, substantially decreased plasma HCV RNA levels in a prior clinical study. The present study evaluated viral kinetics and safety during dosing with telaprevir alone and in combination with peginterferon alfa-2a for 14

  4. Spotlight on taliglucerase alfa in the treatment of pediatric patients with type 1 Gaucher disease

    Directory of Open Access Journals (Sweden)

    Gupta P

    2017-06-01

    Full Text Available Punita Gupta,1 Gregory M Pastores2 1Division of Genetics, Department of Pediatrics, St. Joseph’s Children’s Hospital, Paterson, New Jersey, USA; 2National Center for Inherited Metabolic Disorders, Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland Abstract: Gaucher disease (GD is a heritable storage disorder caused by functional defects of the lysosomal acid β-glucosidase and the accumulation of glucosylceramide within macrophages, resulting in multiple organ dysfunction. There are three commercially available enzyme replacement therapy (ERT products for the treatment of GD type 1 (GD1: imiglucerase, velaglucerase alfa, and taliglucerase alfa. Imiglucerase and velaglucerase alfa are produced in different mammalian cell systems; imiglucerase requires postproduction deglycosylation to expose terminal α-mannose residues, which are required for mannose receptor-mediated uptake by target macrophages. These steps are critical to the success of ERT for the treatment of visceral and hematologic manifestations of GD. Taliglucerase alfa is the first US Food and Drug Administration-approved plant-cell-expressed recombinant human protein, using carrot root cell cultures. Furthermore, it does not require postproduction glycosidic modifications. It is indicated for treatment of adults with GD1 in the US, Israel, Australia, Canada, Chile, Brazil, and other countries, and it is additionally approved for the treatment of pediatric patients in the US, Australia, and Canada and for the treatment of hematologic manifestations in pediatric patients with Type 3 GD in Canada and other countries. Our review focuses on the role of taliglucerase alfa in the pediatric population. A literature search through PubMed (from 1995 up till November 2016 of English language articles was performed with the following terms: Gaucher disease, lysosomal storage disease, taliglucerase. Secondary and tertiary references were obtained by reviewing

  5. Drotrecogin alfa (activated in severe sepsis: a systematic review and new cost-effectiveness analysis

    Directory of Open Access Journals (Sweden)

    Brophy James M

    2007-06-01

    Full Text Available Abstract Background Activated drotrecogin alfa (human activated protein C, rhAPC, is produced by recombinant DNA technology, and purports to improve clinical outcomes by counteracting the inflammatory and thrombotic consequences of severe sepsis. Controversy exists around the clinical benefits of this drug and an updated economic study that considers this variability is needed. Methods A systematic literature review was performed using Medline, Embase and the International Network of Agencies for Health Technology Assessment (INAHTA databases to determine efficacy, safety and previous economic studies. Our economic model was populated with systematic estimates of these parameters and with population life tables for longer term survival information. Monte Carlo simulations were used to estimate the incremental cost-effectiveness ratios (ICERs and variance for the decision analytic models. Results Two randomized clinical trials (RCTS of drotrecogin alfa in adults with severe sepsis and 8 previous economic studies were identified. Although associated with statistical heterogeneity, a pooled analysis of the RCTs did not show a statistically significant 28-day mortality benefit for drotrecogin alfa compared to placebo either for all patients (RR: 0.93, 95% CI: 0.69, 1.26 or those at highest risk as measured by APACHE II ≥ 25 (RR: 0.90, 95% CI: 0.54, 1.49. Our economic analysis based on the totality of the available clinical evidence suggests that the cost-effectiveness of drotrecogin alfa is uncertain ( Conclusion The evidence supporting the clinical and economic attractiveness of drotrecogin alfa is not conclusive and further research appears to be indicated.

  6. Comparison of GPS-TEC measurements with NeQuick2 and IRI model predictions in the low latitude East African region during varying solar activity period (1998 and 2008-2015)

    Science.gov (United States)

    Mengistu, E.; Damtie, B.; Moldwin, M. B.; Nigussie, M.

    2018-03-01

    shorter timescales (roughly periods of less than 16 days). In this case, NeQuick2 derived TEC shows better agreement with a long term period variations of GPS-TEC, while IRI-2016 and IRI-2007 show better agreement with observations during short term periodic variations. This indicates that the dependence of NeQuick2 derived TEC on F10.7 is seasonal. Hence, we suggest that representation of geomagnetic activity indices is required for better performance over the low latitude region.

  7. Stroke in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia treated with Darbepoetin Alfa

    DEFF Research Database (Denmark)

    Skali, Hicham; Parving, Hans-Henrik; Parfrey, Patrick S

    2011-01-01

    More strokes were observed in the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT) among patients assigned to darbepoetin alfa. We sought to identify baseline characteristics and postrandomization factors that might explain this association....

  8. Evaluating the transport layer of the ALFA framework for the Intel(®) Xeon Phi(™) Coprocessor

    OpenAIRE

    Santogidis, Aram; Hirstius, Andreas; Lalis, Spyros

    2015-01-01

    The ALFA framework supports the software development of major High Energy Physics experiments. As part of our research effort to optimize the transport layer of ALFA, we focus on profiling its data transfer performance for inter-node communication on the Intel Xeon Phi Coprocessor. In this article we present the collected performance measurements with the related analysis of the results. The optimization opportunities that are discovered, help us to formulate the future plans of enabling high...

  9. ATLAS-ALFA measurements on the total cross section and diffraction

    CERN Document Server

    Mortensen, Simon Stark; The ATLAS collaboration

    2015-01-01

    The measurement of the total pp cross section at the LHC at $\\sqrt{s}=7$ TeV with the ALFA subdetector of ATLAS is presented in this talk. In a special run with $\\beta^*=90$ m beam optics corresponding to an integrated luminosity of 80 $\\text{mb}^{-1}$ the differential elastic cross section is measured in the range from $-t=0.0025\\text{ GeV}^2$ to $-t=0.38\\text{ GeV}^2$. The total cross section $\\sigma(pp\\rightarrow X)$ is extracted using the Optical Theorem by extrapolation of the differential elastic cross section to $t=0\\text{ GeV}^2$. Prospects for diffractive measurements using ALFA to detect the intact proton(s) is also discussed.

  10. Pancreatitis induced by pegylated interferon alfa-2b in a patient affected by chronic hepatitis C.

    Science.gov (United States)

    Cecchi, Enrica; Forte, Paolo; Cini, Elisabetta; Banchelli, Grazia; Ferlito, Chiara; Mugelli, Alessandro

    2004-01-01

    A middle-aged man was admitted to the ED because of nausea and vomiting, abdominal distention and fainting. A blood analysis revealed high levels of serum amylase and lipase, confirming a diagnosis of acute pancreatitis. The history showed that the patient had self-administered a single dose of pegylated interferon alfa-2b and ribavirin daily for 7 days for chronic hepatitis C. The medications were stopped and his condition gradually improved. In agreement with the literature and the Naranjo algorythm result, pegylated interferon alfa-2b is associated with acute pancreatitis. Identification of a few signs and symptoms is the first 'signal' in preventing a serious drug-induced adverse event.

  11. Preparation And Properties Of Bionanocomposite Films Reinforced With Nanocellulose Isolated From Moroccan Alfa Fibres

    Directory of Open Access Journals (Sweden)

    Youssef Benyoussif

    2015-09-01

    Full Text Available Nanocellulose (NC were extracted from the Moroccan Alfa plant (Stipa tenacissima L. and characterised. These Alfa cellulosic nanoparticles were used as reinforcing phase to prepare bionanocomposite films using carboxymethyl cellulose as matrix. These films were obtained by the casting/evaporation method. The crystallinity of NC was analysed by X-ray diffraction, the dimension of NC by atomic force microscopy, molecular interactions due to incorporation of NC in carboxymethyl cellulose (CMC matrix were supported by Fourier transforms infrared (FTIR spectroscopy. The properties of the ensuing bionanocomposite films were investigated using tensile tests, water vapour permeability (WVP study and thermogravimetric analysis. With the progress of purification treatment of cellulose, the crystallinity is improved compared to the untreated fibres; this can be explained by the disappearance of the amorphous areas in cellulose chain of the plant. Consequently, the tensile modulus and tensile strength of CMC film increased by 60 and 47%, respectively, in the bionanocomposite films with 10 wt% of NC, and decrease by 8.6% for WVP with the same content of NC. The NC obtained from the Moroccan Alfa fibres can be used as a reinforcing agent for the preparation of bionanocomposites, and they have a high potential for the development of completely biodegradable food packaging materials.

  12. Human factors engineering and design validation for the redesigned follitropin alfa pen injection device.

    Science.gov (United States)

    Mahony, Mary C; Patterson, Patricia; Hayward, Brooke; North, Robert; Green, Dawne

    2015-05-01

    To demonstrate, using human factors engineering (HFE), that a redesigned, pre-filled, ready-to-use, pre-asembled follitropin alfa pen can be used to administer prescribed follitropin alfa doses safely and accurately. A failure modes and effects analysis identified hazards and harms potentially caused by use errors; risk-control measures were implemented to ensure acceptable device use risk management. Participants were women with infertility, their significant others, and fertility nurse (FN) professionals. Preliminary testing included 'Instructions for Use' (IFU) and pre-validation studies. Validation studies used simulated injections in a representative use environment; participants received prior training on pen use. User performance in preliminary testing led to IFU revisions and a change to outer needle cap design to mitigate needle stick potential. In the first validation study (49 users, 343 simulated injections), in the FN group, one observed critical use error resulted in a device design modification and another in an IFU change. A second validation study tested the mitigation strategies; previously reported use errors were not repeated. Through an iterative process involving a series of studies, modifications were made to the pen design and IFU. Simulated-use testing demonstrated that the redesigned pen can be used to administer follitropin alfa effectively and safely.

  13. Efficacy of Alfa EEG wave biofeedback in the management of anxiety

    Directory of Open Access Journals (Sweden)

    Pookala Bhat

    2010-01-01

    Full Text Available Background: Biofeedback is a technique in which people are trained to improve their health by learning to control certain internal bodily processes that normally occur involuntarily. Various studies in the past have shown usefulness of Alfa electroencephalographic (EEG biofeedback in the alleviation of anxiety symptoms. Though most of the psychiatric centers in the armed forces have this facility, not much work has been done in our setup to assess its efficacy in the management of anxiety. Hence this study was undertaken. Materials and Methods: This study was carried out in a multispecialty Command Hospital by enrolling 100 patients with psychiatric diagnosis from both inpatient and outpatient services. The anxiety level was assessed clinically and by using Hamilton Anxiety Scale and Taylor′s Manifest Anxiety Scale. One group of 50 patients was treated with Alfa EEG biofeedback sessions only, 5 times in a week for 8 weeks, along with specific pharmacotherapy. The other group was treated with appropriate dose of anxiolytics. The anxiety level was reassessed after 4 weeks and 8 weeks. Results: The response was better for mixed anxiety and depressive disorder with pharmacotherapy than with the biofeedback, but female patients showed better response with EEG biofeedback. Conclusion: In the short term, Alfa EEG biofeedback therapy is almost as efficacious as pharmacological intervention in the management of anxiety symptoms, and relatively more useful in females.

  14. Alfa-Omega: o pensamento crítico em livro

    Directory of Open Access Journals (Sweden)

    Sandra Reimão

    Full Text Available ResumoEste artigo apresenta a síntese de uma pesquisa que, por meio de fontes bibliográficas, análise documental e entrevistas, buscou traçar a história da Editora Alfa-Omega e compreender seu espaço e sua especificidade na complexa indústria do livro no Brasil. Fundada em São Paulo, em 1973, por Fernando e Claudete Mangarielo, a editora Alfa-Omega vem desde então “publicando o pensamento crítico brasileiro”. Em seus quatro primeiros anos de atividade, de 1973 a 1976, a editora publicou 44 títulos, sendo 16 deles livros de autoria de docentes da USP, época em que o meio universitário era um importante setor de oposição ao regime. A Editora, atualmente (2014, conta com mais de 200 títulos em catálogo. Nos últimos 14 anos, a Alfa-Omega, que na década de 1990 conheceu um grande rebaixamento de vendas, investe fortemente na internet e nos recursos digitais como ferramentas de produção e comercialização de livros. A editora mantém inalterados os princípios de sua linha editorial há mais de 40 anos. Conclui-se observando a dificuldade de manutenção de editoras de porte médio segmentadas no campo político da esquerda e a importância dessas editoras na promoção e manutenção da bibliodiversidade.

  15. GSI Helmholz Centre for Heavy Ion Research - ALFA: Next generation concurrent framework for ALICE and FAIR experiments

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    FAIR is a new, unique international accelerator facility for the research with antiprotons and ions. It is being built at the GSI Darmstadt in Hesse, Germany. The commonalities between the ALICE and FAIR experiments and their computing requirements led to the development of a common software framework in an experiment independent way; ALFA (ALICE-FAIR framework). ALFA is designed for high quality parallel data processing and reconstruction on heterogeneous computing systems. It provides a data transport layer and the capability to coordinate multiple data processing components. ALFA is a flexible, elastic system which balances reliability and ease of development with performance by using a message based multi-processing in addition to multi-threading. The framework allows for usage of heterogeneous computing architectures by offloading (portions of code are accelerated on the device) or natively (where the full program is executed on the device ).

  16. A Patient Friendly Corifollitropin Alfa Protocol without Routine Pituitary Suppression in Normal Responders.

    Science.gov (United States)

    Wang, Huai-Ling; Lai, Hsing-Hua; Chuang, Tzu-Hsuan; Shih, Yu-Wei; Huang, Shih-Chieh; Lee, Meng-Ju; Chen, Shee-Uan

    2016-01-01

    The release of corifollitropin alfa simplifies daily injections of short-acting recombinant follicular stimulating hormone (rFSH), and its widely-used protocol involves short-acting gonadotropins supplements and a fixed GnRH antagonist regimen, largely based on follicle size. In this study, the feasibility of corifollitropin alfa without routine pituitary suppression was evaluated. A total of 288 patients were stimulated by corifollitropin alfa on cycle day 3 following with routine serum hormone monitoring and follicle scanning every other day after 5 days of initial stimulation, and a GnRH antagonist (0.25 mg) was only used prophylactically when the luteinizing hormone (LH) was ≧ 6 IU/L (over half of the definitive LH surge). The incidence of premature LH surge (≧ 10 IU/L) was 2.4% (7/288) before the timely injection of a single GnRH antagonist, and the elevated LH level was dropped down from 11.9 IU/L to 2.2 IU/L after the suppression. Two hundred fifty-one patients did not need any antagonist (87.2% [251/288]) throughout the whole stimulation. No adverse effects were observed regarding oocyte competency (fertilization rate: 78%; blastocyst formation rate: 64%). The live birth rate per OPU cycle after the first cryotransfer was 56.3% (161/286), and the cumulative live birth rate per OPU cycle after cyrotransfers was 69.6% (199/286). Of patients who did and did not receive GnRH antagonist during stimulation, no significant difference existed in the cumulative live birth rates (78.4% vs. 68.3%, p = 0.25). The results demonstrated that the routine GnRH antagonist administration is not required in the corifollitropin-alfa cycles using a flexible and hormone-depended antagonist regimen, while the clinical outcome is not compromised. This finding reveals that the use of a GnRH antagonist only occasionally may be needed.

  17. A Patient Friendly Corifollitropin Alfa Protocol without Routine Pituitary Suppression in Normal Responders.

    Directory of Open Access Journals (Sweden)

    Huai-Ling Wang

    Full Text Available The release of corifollitropin alfa simplifies daily injections of short-acting recombinant follicular stimulating hormone (rFSH, and its widely-used protocol involves short-acting gonadotropins supplements and a fixed GnRH antagonist regimen, largely based on follicle size. In this study, the feasibility of corifollitropin alfa without routine pituitary suppression was evaluated. A total of 288 patients were stimulated by corifollitropin alfa on cycle day 3 following with routine serum hormone monitoring and follicle scanning every other day after 5 days of initial stimulation, and a GnRH antagonist (0.25 mg was only used prophylactically when the luteinizing hormone (LH was ≧ 6 IU/L (over half of the definitive LH surge. The incidence of premature LH surge (≧ 10 IU/L was 2.4% (7/288 before the timely injection of a single GnRH antagonist, and the elevated LH level was dropped down from 11.9 IU/L to 2.2 IU/L after the suppression. Two hundred fifty-one patients did not need any antagonist (87.2% [251/288] throughout the whole stimulation. No adverse effects were observed regarding oocyte competency (fertilization rate: 78%; blastocyst formation rate: 64%. The live birth rate per OPU cycle after the first cryotransfer was 56.3% (161/286, and the cumulative live birth rate per OPU cycle after cyrotransfers was 69.6% (199/286. Of patients who did and did not receive GnRH antagonist during stimulation, no significant difference existed in the cumulative live birth rates (78.4% vs. 68.3%, p = 0.25. The results demonstrated that the routine GnRH antagonist administration is not required in the corifollitropin-alfa cycles using a flexible and hormone-depended antagonist regimen, while the clinical outcome is not compromised. This finding reveals that the use of a GnRH antagonist only occasionally may be needed.

  18. Alfa hemolisina induce un aumento de calcio eritrocitario: estudio por FLIM (Fluorescence Lifetime Imaging Microscopy)

    OpenAIRE

    Sánchez, Susana; Bakás, Laura; Gratton, Enrico; Herlax, Vanesa Silvana

    2010-01-01

    Alfa hemolisina (HlyA), miembro representativo de la familia de toxinas RTX (Repeat in toxin), es una toxina proteica que ciertas cepas patógenas de E.coli secretan específicamente al medio. Está demostrado que la toxina es un factor importante de virulencia en enfermedades extraintestinales. Además, se ha determinado que el desarrollo de falla renal aguda aumenta significativamente la mortalidad en pacientes con shock séptico producido por bacterias Gram negativas, en los que distintos facto...

  19. Nebulised dornase alfa versus placebo or hypertonic saline in adult critically ill patients

    DEFF Research Database (Denmark)

    Claudius, Casper; Perner, Anders; Møller, Morten Hylander

    2015-01-01

    a systematic review with meta-analysis and trial sequential analysis (TSA) using the Cochrane Collaboration methodology. Eligible trials were randomised clinical trials comparing nebulised dornase alfa with placebo, no prophylaxis, or hypertonic saline. The predefined outcome measures were all-cause mortality...... of the primary estimate was assessed by TSA. RESULTS: Two trials (n = 63) were included; both were judged to have high risk of bias. There was no statistically significant difference in mortality (random effects model RR (95 % CI) 0.73 (0.09-5.77); P = 0.24; I (2) = 30 %). TSA could not be conducted because less...

  20. Effect of darbepoetin alfa on physical function in patients undergoing surgery for colorectal cancer

    DEFF Research Database (Denmark)

    Nørager, C B; Jensen, M B; Madsen, M R

    2007-01-01

    OBJECTIVE: To study whether perioperative treatment with darbepoetin alfa (DA) improves physical performance following colorectal cancer surgery. METHODS: Patients admitted for planned colorectal cancer surgery were randomized to receive either weekly placebo or DA 300 or 150 microg depending...... on the hemoglobin (Hb) concentration. Patients were assessed 10 days before, as well as 7 and 30 days after surgery for work capacity, postural sway, muscle strength, fatigue and quality of life (QoL). The primary outcome measure were the changes in patients' physical performance from preoperative to postoperative...... differences between the 2 groups on days 7 or 30 for fatigue, postural sway and QoL. DA treatment significantly (p

  1. A redesigned follitropin alfa pen injector for infertility: results of a market research study

    Directory of Open Access Journals (Sweden)

    Abbotts C

    2011-06-01

    Full Text Available Carole Abbotts1, Cristiana Salgado-Braga2, Céline Audibert-Gros31Pharmaceutical Marketing Research Consultancy, London, UK; 2Fertility and Endocrinology Global Business Unit, 3Business Intelligence, Merck Serono SA, Geneva, SwitzerlandBackground: The purpose of this study was to evaluate patient-learning and nurse-teaching experiences when using a redesigned prefilled, ready-to-use follitropin alfa pen injector.Methods: Seventy-three UK women of reproductive age either administering daily treatment with self-injectable gonadotropins or about to start gonadotropin treatment for infertility (aged 24–47 years; 53 self-injection-experienced and 20 self-injection-naïve and 28 nurses from UK infertility clinics were recruited for the study. Following instruction, patients and nurses used the redesigned follitropin alfa pen to inject water into an orange and completed questionnaires to evaluate their experiences with the pen immediately after the simulated injections.Results: Most (88%, n = 64 patients found it easy to learn how to use the pen. Among injection-experienced patients, 66% (n = 35 agreed that the redesigned pen was easier to learn to use compared with their current method and 70% (n = 37 also said they would prefer its use over current devices for all injectable fertility medications. All nurses considered the redesigned pen easy to learn and believed it would be easy to teach patients how to use. Eighty-six percent (n = 24 of the nurses thought it was easy to teach patients to determine the remaining dose to be dialed and injected in a second pen if the initial dose was incomplete. Compared with other injection devices, 96% (n = 27 thought it was "much easier" to "as easy" to teach patients to use the redesigned pen. Based on ease of teaching, 68% (n = 19 of nurses would choose to teach the pen in preference to any other injection method. Almost all (93%, n = 26 nurses considered that having the same pen format for a range of

  2. Maintenance therapy with peginterferon alfa-2b does not prevent hepatocellular carcinoma in cirrhotic patients with chronic hepatitis C.

    Science.gov (United States)

    Bruix, Jordi; Poynard, Thierry; Colombo, Massimo; Schiff, Eugene; Burak, Kelly; Heathcote, Elizabeth J L; Berg, Thomas; Poo, Jorge-Luis; Mello, Carlos Brandao; Guenther, Rainer; Niederau, Claus; Terg, Ruben; Bedossa, Pierre; Boparai, Navdeep; Griffel, Louis H; Burroughs, Margaret; Brass, Clifford A; Albrecht, Janice K

    2011-06-01

    Several studies have reported that low doses of interferon can delay the development of hepatocellular carcinoma (HCC) and progression of chronic hepatitis C. We investigated the incidence of clinical events among participants of the Evaluation of PegIntron in Control of Hepatitis C Cirrhosis (EPIC)3 program. Data were analyzed from an open-label randomized study of patients with chronic hepatitis C who had failed to respond to interferon alfa plus ribavirin. All patients had compensated cirrhosis with no evidence of HCC. Patients received peginterferon alfa-2b (0.5 μg/kg/week; n=311) or no treatment (controls, n=315) for a maximum period of 5 years or until 98 patients had a clinical event (hepatic decompensation, HCC, death, or liver transplantation). The primary measure of efficacy was time until the first clinical event. There was no significant difference in time to first clinical event among patients who received peginterferon alfa-2b compared with controls (hazard ratio [HR], 1.452; 95% confidence interval [CI]: 0.880-2.396). There was no decrease in the development of HCC with therapy. The time to disease progression (clinical events or new or enlarged varices) was significantly longer for patients who received peginterferon alfa-2b compared with controls (HR, 1.564; 95% CI: 1.130-2.166). In a prospectively defined subanalysis of patients with baseline portal hypertension, peginterferon alfa-2b significantly increased the time to first clinical event compared with controls (P=.016). There were no new safety observations. Maintenance therapy with peginterferon alfa-2b is not warranted in all patients and does not prevent HCC. However, there is a potential clinical benefit of long-term suppressive therapy in patients with preexisting portal hypertension. Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.

  3. Corifollitropin alfa followed by rFSH in a GnRH antagonist protocol for poor ovarian responder patients

    DEFF Research Database (Denmark)

    Polyzos, Nikolaos P; Devos, Michel; Humaidan, Peter

    2013-01-01

    OBJECTIVE: To identify whether women with poor ovarian response may benefit from treatment with corifollitropin alfa in a GnRH antagonist protocol. DESIGN: Retrospective pilot study. SETTING: University-based tertiary care center. PATIENT(S): Poor ovarian responders fulfilling the Bologna criteria...... developed by European Society for Human Reproduction and Embryology Consensus Group. INTERVENTION(S): Corifollitropin alfa (150 μg) followed by 300 IU rFSH in a GnRH antagonist protocol. MAIN OUTCOME MEASURE(S): Endocrinologic profile and ongoing pregnancy rates. RESULT(S): Among 43 women treated...

  4. alfa-Deuterium kinetic isotope effects in reactions of methyllithium. Is better aggregation the cause of lower reactivity?

    DEFF Research Database (Denmark)

    Holm, Torkil

    1996-01-01

    The value of kH/kD for alfa deuterium kinetic isotope effects for the reaction of methyllithium and methylmagnesium iodid with a series of substrates are consistently ca. 10-15 % higher for the lithium reagent. This may indicate a pre-equilibrium......The value of kH/kD for alfa deuterium kinetic isotope effects for the reaction of methyllithium and methylmagnesium iodid with a series of substrates are consistently ca. 10-15 % higher for the lithium reagent. This may indicate a pre-equilibrium...

  5. FTIR spectroscopy and X-ray powder diffraction characterization of microcrystalline cellulose obtained from alfa fibers

    Directory of Open Access Journals (Sweden)

    Trache D.

    2013-07-01

    Full Text Available Many cereal straws have been used as raw materials for the preparation of microcrystalline cellulose (MCC. These raw materials were gradually replaced with wood products; nevertheless about 10% of the world overall pulp production is obtained from non-wood raw material. The main interest in pulp made from straw is that it provides excellent fibres for different industries with special properties, and that it is the major available source of fibrous raw material in some geographical areas. The aim of the present work was to characterize microcrystalline cellulose prepared from alfa fibers using the hydrolysis process. The products obtained are characterized with FTIR spectroscopy and X-ray powder diffraction. As a result, FTIR spectroscopy is an appropriate technique for studying changes occurred by any chemical treatment. The spectrum of alfa grass stems shows the presence of lignin and hemicelluloses. However, the cellulose spectrum indicates that the extraction of lignin and hemicellulose was effective. The X-ray analysis indicates that the microcrystalline cellulose is more crystalline than the source material.

  6. De-squeeze the beams: the TOTEM and ATLAS/ALFA experiments

    CERN Multimedia

    Stefania Pandolfi

    2016-01-01

    A special week-long proton–proton run with larger beam sizes at the interaction point is intended to probe the p-p elastic scattering regime at small angles.   Nicola Turini, deputy spokesperson for TOTEM, in front of one of the experiment’s ‘Roman Pot’ detectors in the LHC tunnel. (Photo: Maximilien Brice/CERN) Usually, the motto of the LHC is “maximum luminosity”. But for a few days per year, the LHC ignores its motto to run at very low luminosity for the forward experiments. This week, the LHC will provide the TOTEM and ATLAS/ALFA experiments with data for a broad physics programme. The TOTEM experiment at Point 5 and the ATLAS/ALFA experiment at Point 1 study the elastic scattering of protons, which are not observable in normal operation runs. In the elastic scattering process, the two protons survive their encounter intact and only change directions by exchanging momentum. To allow this special run, the operators play with the so-c...

  7. Mango resistance to fruit flies. II - resistance of the alfa cultivar

    Energy Technology Data Exchange (ETDEWEB)

    Rossetto, C.J.; Bortoletto, N., E-mail: rossetto@iac.sp.gov.b [Agencia Paulista de Tecnologia dos Agronegocios (APTA), Votuporanga, SP (Brazil). Polo Regional do Noroeste Paulista; Walder, J.M.M.; Mastrangelo, T. de A., E-mail: jmwalder@cena.usp.b [Centro de Energia Nuclear na Agricultura (CENA/USP), Piracicaba, SP (Brazil); Carvalho, C.R.L.; Castro, J.V. de, E-mail: climonta@iac.sp.gov.b, E-mail: josalba@iac.sp.gov.b [Instituto Agronomico de Campinas, SP (Brazil); Pinto, A.C. de Q. [EMBRAPA, Brasilia, DF (Brazil); Cortelazzo, A.L., E-mail: angelo@unicamp.b [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Inst. de Biologia

    2006-07-01

    The percentage of infested mango fruits of five selected mango varieties was evaluated during three years under field conditions. Three varieties with field resistance to fruit flies had less then 10% of fruits infested. Tommy Atkins, the susceptible commercial check, had 42,9% and the susceptible check had 98.9 % of infested fruits. The three field resistant varieties plus the susceptible commercial check, Tommy Atkins, were further tested in laboratory, under caged conditions, with artificial infestation of Anastrepha obliqua. The attempts of oviposition and the number of pupae developed from each fruit were evaluated. Under caged conditions, the cultivar Alfa maintained its field resistance and Espada Stahl and IAC 111 lost the field resistance and were as susceptible as Tommy Atkins. The attempts of oviposition were positively and highly correlated with the number of pupae developed in the fruits. Non preference for oviposition was confirmed as the main mechanism of resistance of mango fruits to fruit flies. In the absence of a more susceptible variety (no choice test) the cultivar Alfa has kept the resistance (author)

  8. Mango resistance to fruit flies. II - resistance of the alfa cultivar

    International Nuclear Information System (INIS)

    Rossetto, C.J.; Bortoletto, N.; Carvalho, C.R.L.; Castro, J.V. de; Pinto, A.C. de Q.; Cortelazzo, A.L.

    2006-01-01

    The percentage of infested mango fruits of five selected mango varieties was evaluated during three years under field conditions. Three varieties with field resistance to fruit flies had less then 10% of fruits infested. Tommy Atkins, the susceptible commercial check, had 42,9% and the susceptible check had 98.9 % of infested fruits. The three field resistant varieties plus the susceptible commercial check, Tommy Atkins, were further tested in laboratory, under caged conditions, with artificial infestation of Anastrepha obliqua. The attempts of oviposition and the number of pupae developed from each fruit were evaluated. Under caged conditions, the cultivar Alfa maintained its field resistance and Espada Stahl and IAC 111 lost the field resistance and were as susceptible as Tommy Atkins. The attempts of oviposition were positively and highly correlated with the number of pupae developed in the fruits. Non preference for oviposition was confirmed as the main mechanism of resistance of mango fruits to fruit flies. In the absence of a more susceptible variety (no choice test) the cultivar Alfa has kept the resistance (author)

  9. Immunogenicity of glycans on biotherapeutic drugs produced in plant expression systems—The taliglucerase alfa story

    Science.gov (United States)

    Rup, Bonita; Alon, Sari; Amit-Cohen, Bat-Chen; Brill Almon, Einat; Chertkoff, Raul; Rudd, Pauline M.

    2017-01-01

    Plants are a promising alternative for the production of biotherapeutics. Manufacturing in-planta adds plant specific glycans. To understand immunogenic potential of these glycans, we developed a validated method to detect plant specific glycan antibodies in human serum. Using this assay, low prevalence of pre-existing anti-plant glycan antibodies was found in healthy humans (13.5%) and in glucocerebrosidase-deficient Gaucher disease (GD) patients (5%). A low incidence (9% in naïve patient and none in treatment experienced patients) of induced anti-plant glycan antibodies was observed in GD patients after up to 30 months replacement therapy treatment with taliglucerase alfa, a version of human glucocerebrosidase produced in plant cells. Detailed evaluation of clinical safety and efficacy endpoints indicated that anti-plant glycan antibodies did not affect the safety or efficacy of taliglucerase alfa in patients. This study shows the benefit of using large scale human trials to evaluate the immunogenicity risk of plant derived glycans, and indicates no apparent risk related to anti-plant glycan antibodies. PMID:29088235

  10. Hyporesponsiveness to Darbepoetin Alfa in Patients With Heart Failure and Anemia in the RED-HF Study (Reduction of Events by Darbepoetin Alfa in Heart Failure): Clinical and Prognostic Associations.

    Science.gov (United States)

    van der Meer, Peter; Grote Beverborg, Niels; Pfeffer, Marc A; Olson, Kurt; Anand, Inder S; Westenbrink, B Daan; McMurray, John J V; Swedberg, Karl; Young, James B; Solomon, Scott D; van Veldhuisen, Dirk J

    2018-02-01

    A poor response to erythropoiesis-stimulating agents such as darbepoetin alfa has been associated with adverse outcomes in patients with diabetes mellitus, chronic kidney disease, and anemia; whether this is also true in heart failure is unclear. We performed a post hoc analysis of the RED-HF trial (Reduction of Events by Darbepoetin Alfa in Heart Failure), in which 1008 patients with systolic heart failure and anemia (hemoglobin level, 9.0-12.0 g/dL) were randomized to darbepoetin alfa. We examined the relationship between the hematopoietic response to darbepoetin alfa and the incidence of all-cause death or first heart failure hospitalization during a follow-up of 28 months. For the purposes of the present study, patients in the lowest quartile of hemoglobin change after 4 weeks were considered nonresponders. The median initial hemoglobin change in nonresponders (n=252) was -0.25 g/dL and +1.00 g/dL in the remainder of patients (n=756). Worse renal function, lower sodium levels, and less use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers were independently associated with nonresponse. Although a low endogenous erythropoietin level helped to differentiate responders from nonresponders, its predictive value in a multivariable model was poor (C statistic=0.69). Nonresponders had a higher rate of all-cause death or first heart failure hospitalization (hazard ratio, 1.25; 95% confidence interval, 1.02-1.54) and a higher risk of all-cause mortality (hazard ratio, 1.30; 95% confidence interval, 1.04-1.63) than responders. A poor response to darbepoetin alfa was associated with worse outcomes in heart failure patients with anemia. Patients with a poor response were difficult to identify using clinical and biochemical biomarkers. URL: https://www.clinicaltrials.gov. Unique identifier: NCT00358215. © 2018 American Heart Association, Inc.

  11. Accurate Learning with Few Atlases (ALFA): an algorithm for MRI neonatal brain extraction and comparison with 11 publicly available methods.

    Science.gov (United States)

    Serag, Ahmed; Blesa, Manuel; Moore, Emma J; Pataky, Rozalia; Sparrow, Sarah A; Wilkinson, A G; Macnaught, Gillian; Semple, Scott I; Boardman, James P

    2016-03-24

    Accurate whole-brain segmentation, or brain extraction, of magnetic resonance imaging (MRI) is a critical first step in most neuroimage analysis pipelines. The majority of brain extraction algorithms have been developed and evaluated for adult data and their validity for neonatal brain extraction, which presents age-specific challenges for this task, has not been established. We developed a novel method for brain extraction of multi-modal neonatal brain MR images, named ALFA (Accurate Learning with Few Atlases). The method uses a new sparsity-based atlas selection strategy that requires a very limited number of atlases 'uniformly' distributed in the low-dimensional data space, combined with a machine learning based label fusion technique. The performance of the method for brain extraction from multi-modal data of 50 newborns is evaluated and compared with results obtained using eleven publicly available brain extraction methods. ALFA outperformed the eleven compared methods providing robust and accurate brain extraction results across different modalities. As ALFA can learn from partially labelled datasets, it can be used to segment large-scale datasets efficiently. ALFA could also be applied to other imaging modalities and other stages across the life course.

  12. Daclatasvir plus peginterferon alfa and ribavirin for treatment-naive chronic hepatitis C genotype 1 or 4 infection

    DEFF Research Database (Denmark)

    Hézode, Christophe; Hirschfield, Gideon M; Ghesquiere, Wayne

    2015-01-01

    OBJECTIVE: To evaluate the safety and efficacy of daclatasvir, an HCV NS5A inhibitor with pangenotypic activity, administered with peginterferon-alfa-2a/ribavirin. DESIGN: In this Phase 2b double-blind, placebo-controlled study, treatment-naive adults with HCV genotype 1 (N=365) or 4 (N=30...

  13. Interferon alfa for chronic hepatitis B infection: increased efficacy of prolonged treatment. The European Concerted Action on Viral Hepatitis (EUROHEP)

    NARCIS (Netherlands)

    Janssen, H. L.; Gerken, G.; Carreño, V.; Marcellin, P.; Naoumov, N. V.; Craxi, A.; Ring-Larsen, H.; Kitis, G.; van Hattum, J.; de Vries, R. A.; Michielsen, P. P.; ten Kate, F. J.; Hop, W. C.; Heijtink, R. A.; Honkoop, P.; Schalm, S. W.

    1999-01-01

    Interferon alfa (IFN-alpha) is the primary treatment for chronic hepatitis B. The standard duration of IFN-alpha therapy is considered 16 weeks; however, the optimal treatment length is still poorly defined. We evaluated the efficacy and acceptability of prolonged IFN-alpha treatment in patients

  14. The Arecibo Legacy Fast ALFA Survey : X. The HI Mass Function and Omega_HI From the 40% ALFALFA Survey

    NARCIS (Netherlands)

    Martin, Ann M.; Papastergis, Emmanouil; Giovanelli, Riccardo; Haynes, Martha P.; Springob, Christopher M.; Stierwalt, Sabrina

    2010-01-01

    The Arecibo Legacy Fast ALFA (ALFALFA) survey has completed source extraction for 40% of its total sky area, resulting in the largest sample of HI-selected galaxies to date. We measure the HI mass function from a sample of 10,119 galaxies with 6.2

  15. Dificuldades na identificação laboratorial da talassemia alfa Difficulty on laboratory identification of alpha thalassemia

    Directory of Open Access Journals (Sweden)

    Karlla Greick Batista Dias-Penna

    2010-04-01

    Full Text Available Introdução: Talassemia alfa é uma síndrome associada à redução da síntese de cadeias de globina do tipo alfa. A gravidade das manifestações clínicas está relacionada com a quantidade de globinas produzida e a estabilidade das cadeias beta presentes em excesso. A talassemia alfa mínima resulta da deleção de apenas um dos quatro genes a (-α/αα. Clinicamente apresenta anemia leve com microcitose ou ausência de anemia, sendo o diagnóstico realizado por meio de visualização da hemoglobina (Hb H por eletroforese alcalina em acetato de celulose ou por identificação de inclusões celulares de Hb H coradas pelo azul de crezil brilhante. Objetivo: Avaliar portadores de talassemia alfa e seus respectivos progenitores, correlacionando perfil hematológico e presença de Hb H, utilizando procedimentos laboratoriais clássicos em três diferentes amostragens. Discussão e conclusão: Os dados obtidos mostram que a presença de Hb H, indicativo de talassemia alfa, pode não ser confirmada em uma análise posterior. Entre os fatores que podem influenciar no não aparecimento de Hb H em pessoa comprovadamente com talassemia alfa está a deficiência de ferro. A talassemia alfa está associada a defeitos envolvendo os genes codificadores da cadeia alfa, mas também pode estar relacionada com desbalanciamento temporário na expressão dos genes globina, diminuição de alfa ou aumento de beta, o que poderia explicar o aparecimento de tetrâmeros de cadeia beta (Hb H, sugerindo diagnóstico de talassemia alfa mínima.Introduction: Alpha thalassemia is a syndrome with associated with the reduction of alpha globin chain synthesis. The severity of clinical manifestations is related to the amount of globins produced and the stability of beta chains that are present in excess. Alpha thalassemia minor is caused by the deletion of one of the four genes a (-α/αα. Clinically, it presents mild anemia with microcytosis or absence of anemia. The

  16. Efficacy and safety of once-weekly intravenous epoetin alfa in maintaining hemoglobin levels in hemodialysis patients.

    Science.gov (United States)

    Locatelli, Francesco; Villa, Giuseppe; Messa, Piergiorgio; Filippini, Armando; Cannella, Giuseppe; De Ferrari, Giacomo; Naso, Agostino; Rossi, Egidio; Formica, Marco; Lombardi, Luigi; Rotolo, Ugo; Conte, Feruccio

    2008-01-01

    Although an erythropoiesis-stimulating agent (ESA) is most frequently administered intravenously for treatment of anemia in patients with chronic kidney disease who are on dialysis, few studies have compared the efficacy of different intravenous (i.v.) dosing schedules. This multicenter, phase IIIb, open-label, controlled study randomized 289 stable hemodialysis patients to continue with conventional dosing of i.v. epoetin alfa or darbepoetin, or to switch to once-weekly i.v. epoetin alfa at the same cumulative weekly starting dose, to maintain hemoglobin levels at 11.0-13.0 g/dL, and within 1.0 g/dL of the baseline value. Hemoglobin levels and ESA doses were recorded every 4 weeks for 28 weeks. Hemoglobin levels fell significantly and ESA doses increased significantly between baseline and week 28 (mean of week 16-28 values) in the once-weekly epoetin alfa group, compared with the conventional treatment group (phemoglobin levels between the groups was 0.73 g/dL (greater than the threshold for therapeutic equivalence of 0.5 g/dL). The changes between groups from baseline was significant at all time points for hemoglobin levels (0.36, 0.46, 0.81, 0.87, 0.78, 0.62 and 0.49 g/dL) and from week 12 for ESA dose (718.5, 1,326.5, 1,732.0, 1,839.7 and 1,959.1 IU/week; p=0.005). Hemoglobin was maintained at the target level in 78% and 84% of patients on conventional dosing, and 67% and 64% of those on once-weekly epoetin alfa in the intention-to-treat (p=0.1) and per protocol (p=0.016) populations, respectively. This study did not show therapeutic equivalence of once-weekly i.v. epoetin alfa with conventional dosing regimens.

  17. Peginterferon alfa-2a and ribavirin in Latino and non-Latino whites with hepatitis C.

    Science.gov (United States)

    Rodriguez-Torres, Maribel; Jeffers, Lennox J; Sheikh, Muhammad Y; Rossaro, Lorenzo; Ankoma-Sey, Victor; Hamzeh, Fayez M; Martin, Paul

    2009-01-15

    Race has been shown to be a factor in the response to therapy for hepatitis C virus (HCV) infection, and limited data suggest that ethnic group may be as well; however, Latinos and other ethnic subpopulations have been underrepresented in clinical trials. We evaluated the effect of Latino ethnic background on the response to treatment with peginterferon alfa-2a and ribavirin in patients infected with HCV genotype 1 who had not been treated previously. In a multicenter, open-label, nonrandomized, prospective study, 269 Latino and 300 non-Latino whites with HCV infection received peginterferon alfa-2a, at a dose of 180 microg per week, and ribavirin, at a dose of 1000 or 1200 mg per day, for 48 weeks, and were followed through 72 weeks. The primary end point was a sustained virologic response. We enrolled Latinos whose parents and grandparents spoke Spanish as their primary language; nonwhite Latinos were excluded. Baseline characteristics were similar in the Latino and non-Latino groups, although higher proportions of Latino patients were 40 years of age or younger, had a body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) of more than 27 or more than 30, and had cirrhosis. The rate of sustained virologic response was higher among non-Latino whites than among Latinos (49% vs. 34%, PLatino whites at week 4 (P=0.045) and throughout the treatment period (PLatino or non-Latino background was an independent predictor of the rate of sustained virologic response in an analysis adjusted for baseline differences in BMI, cirrhosis, and other characteristics. Adherence to treatment did not differ significantly between the two groups. The numbers of patients with adverse events and dose modifications were similar in the two groups, but fewer Latino patients discontinued therapy because of adverse events. Treatment with peginterferon alfa-2a and ribavirin for 48 weeks resulted in rates of sustained virologic response among patients

  18. Using ALFA for high throughput, distributed data transmission in the ALICE O2 system

    Science.gov (United States)

    Wegrzynek, A.; ALICE Collaboration

    2017-10-01

    ALICE (A Large Ion Collider Experiment) is a heavy-ion detector designed to study the physics of strongly interacting matter (the Quark-Gluon Plasma at the CERN LHC (Large Hadron Collider). ALICE has been successfully collecting physics data in Run 2 since spring 2015. In parallel, preparations for a major upgrade of the computing system, called O2 (Online-Offline), scheduled for the Long Shutdown 2 in 2019-2020, are being made. One of the major requirements of the system is the capacity to transport data between so-called FLPs (First Level Processors), equipped with readout cards, and the EPNs (Event Processing Node), performing data aggregation, frame building and partial reconstruction. It is foreseen to have 268 FLPs dispatching data to 1500 EPNs with an average output of 20 Gb/s each. In overall, the O2 processing system will operate at terabits per second of throughput while handling millions of concurrent connections. The ALFA framework will standardize and handle software related tasks such as readout, data transport, frame building, calibration, online reconstruction and more in the upgraded computing system. ALFA supports two data transport libraries: ZeroMQ and nanomsg. This paper discusses the efficiency of ALFA in terms of high throughput data transport. The tests were performed with multiple FLPs pushing data to multiple EPNs. The transfer was done using push-pull communication patterns and two socket configurations: bind, connect. The set of benchmarks was prepared to get the most performant results on each hardware setup. The paper presents the measurement process and final results - data throughput combined with computing resources usage as a function of block size. The high number of nodes and connections in the final set up may cause race conditions that can lead to uneven load balancing and poor scalability. The performed tests allow us to validate whether the traffic is distributed evenly over all receivers. It also measures the behaviour of

  19. Bakterisel Alfa-Amilaz Önemi, Özellikleri ve Üretim Teknolojisi

    OpenAIRE

    Esener, A. Aydın

    2015-01-01

    Enzimler biyolojik katalizörlerdir. Çeşitli mikroorganizmalar, çevrelerini yaşamları için elverişli bir hale getirebilme çabası ile bazı enzimleri bünyelerinde sentez edip hücre duvarından dışarıya salgılamaktadırlar. Alfa-amilaz da bu tür bir enzim olup, özellikle nişasta gibi doğal kaynaklı ham maddelerin parçalanmasında kullanılmaktadır. Endüstride geniş tüketim olanakları bulan bu enzimin, modern yöntemlerle üretilmesi, özellikle fermente olabilir tarım artığı maddelerin bol olduğu Türkiy...

  20. ALGLUCOSIDASE ALFA — A NEW STAGE IN THE THERAPY OF INFANTILE POMPE DISEASE

    Directory of Open Access Journals (Sweden)

    E. N. Basargina

    2014-01-01

    Full Text Available Pompe disease is a rare severe hereditary disease caused by excessive glycogen storage in organs and target tissues due to the acid α-glucosidase gene mutation. Infantile and adult Pompe disease is characterized by involvement of cardiovascular, respiratory and muscular systems in the pathological process. The only specific method of treating Pompe disease is enzyme replacement therapy (intravenous administration of recombinant human acid glucosidase, the effectiveness whereof depends on the time the therapy started. Since such a therapy was introduced into practice, Pompe disease mortality decreased by 79%. 6 children with infantile Pompe disease were observed and treated at the cardiovascular care unit of the Scientific Center of Children’s Health in 2011‑2014. The article presents a clinical case demonstrating capabilities of diagnosing infantile Pompe disease in Russia and effective application of alglucosidase alfa in 4-month-old child. 

  1. VizieR Online Data Catalog: UV counterparts in HI clouds using ALFA surveys (Donovan+, 2015)

    Science.gov (United States)

    Donovan Meyer, J.; Peek, J. E. G.; Putman, M.; Grcevich, J.

    2017-10-01

    GALFA-HI is a survey of Galactic HI conducted with the ALFA seven-beam feed array on the 305 m Arecibo antenna. The survey has both high spatial (FWHM~4') and velocity (0.18 km/s) resolution over 13000 (7520 in DR1) degrees2 of sky between -650 and 650 km/s. Details of the observations and data reduction can be found in Peek et al. (2011ApJS..194...20P). The ALFALFA HI-line survey, now 40% complete, also uses the Arecibo Observatory and its seven-beam feed array to detect potential dwarf galaxies in the vicinity of the Milky Way. The survey, which covers over 7000 (2800 in α.40) deg2 of sky out to 18000 km/s, has the sensitivity to detect 105 Mȯ clouds with 20 km/s linewidths at a distance of 1 Mpc. (2 data files).

  2. A large, multicentre, observational, post-marketing surveillance study of the 2:1 formulation of follitropin alfa and lutropin alfa in routine clinical practice for assisted reproductive technology.

    Science.gov (United States)

    Bühler, Klaus; Naether, Olaf G J; Bilger, Wilma

    2014-01-14

    Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) both have a role to play in follicular development during the natural menstrual cycle. LH supplementation during controlled ovarian stimulation (COS) for assisted reproductive technology (ART) is used for patients with hypogonadotropic hypogonadism. However, the use of exogenous LH in COS in normogonadotropic women undergoing ART is the subject of debate. The aim of this study was to investigate characteristics of infertile women who received the 2:1 formulation of follitropin alfa and lutropin alfa (indicated for stimulation of follicular development in women with severe LH and FSH deficiency) in German clinical practice. A 3-year, multicentre, open-label, observational/non-interventional, post-marketing surveillance study of women (21-45 years) undergoing ART. Primary endpoint: reason for prescribing the 2:1 formulation of follitropin alfa and lutropin alfa. Secondary variables included: COS duration/dose; oocytes retrieved; fertilization; clinical pregnancy; ovarian hyperstimulation syndrome (OHSS). In total, 2220 cycles were assessed; at least one reason for prescribing the 2:1 formulation was given in 1834/2220 (82.6%) cycles. Most common reasons were: poor ovarian response (POR) (39.4%), low baseline LH (17.8%), and age (13.8%). COS: mean dose of the 2:1 formulation on first day, 183.1/91.5 IU; mean duration, 10.8 days. In 2173/2220 (97.9%) cycles, human chorionic gonadotrophin was administered. Oocyte pick-up (OPU) was attempted in 2108/2220 (95.0%) cycles; mean (standard deviation) 8.0 (5.4) oocytes retrieved/OPU cycle. Fertilization (≥1 oocyte fertilized) rates: in vitro fertilization (IVF), 391/439 (89.1%) cycles; intracytoplasmic sperm injection (ICSI)/IVF + ICSI, 1524/1613 (94.5%) cycles. Clinical pregnancy rate: all cycles, 25.9%; embryo transfer cycles, 31.3%. OHSS: hospitalization for OHSS, 8 (0.36%) cycles, Grade 2, 60 (2.7%), and Grade 3, 1 (0.05%). In German routine clinical

  3. JAK-inhibitor tofacitinib suppresses interferon alfa production by plasmacytoid dendritic cells and inhibits arthrogenic and antiviral effects of interferon alfa.

    Science.gov (United States)

    Boor, Patrick P C; de Ruiter, Petra E; Asmawidjaja, Patrick S; Lubberts, Erik; van der Laan, Luc J W; Kwekkeboom, Jaap

    2017-10-01

    Tofacitinib is an oral Janus kinase inhibitor that is effective for the treatment of rheumatoid arthritis and shows encouraging therapeutic effects in several other autoimmune diseases. A prominent adverse effect of tofacitinib therapy is the increased risk of viral infections. Despite its advanced stage of clinical development, the modes of action that mediate the beneficial and adverse effects of tofacitinib in autoimmune diseases remain unclear. Interferon alfa (IFNα) produced by plasmacytoid dendritic cells (PDCs) is critically involved in the pathogenesis of many systemic autoimmune diseases and in immunity to viral infections. Using in vitro culture models with human cells, we studied the effects of tofacitinib on PDC survival and IFNα production, and on arthrogenic and antiviral effects of IFNα. Tofacitinib inhibited the expression of antiapoptotic BCL-A1 and BCL-XL in human PDC and induced PDC apoptosis. TLR7 stimulation upregulated the levels of antiapoptotic Bcl-2 family members and prevented the induction of PDC apoptosis by tofacitinib. However, tofacitinib robustly inhibited the production of IFNα by toll like receptor-stimulated PDC. In addition, tofacitinib profoundly suppressed IFNα-induced upregulation of TLR3 on synovial fibroblasts, thereby inhibiting their cytokine and protease production in response to TLR3 ligation. Finally, tofacitinib counteracted the suppressive effects of IFNα on viral replication. Tofacitinib inhibits PDC survival and IFNα production and suppresses arthrogenic and antiviral effects of IFNα signaling. Inhibition of the IFNα pathway at 2 levels may contribute to the beneficial effects of tofacitinib in autoimmune diseases and explain the increased viral infection rates observed during tofacitinib treatment. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. The role of corifollitropin alfa in controlled ovarian stimulation for IVF in combination with GnRH antagonist

    Directory of Open Access Journals (Sweden)

    Seyhan A

    2011-08-01

    Full Text Available Ayse Seyhan, Baris AtaDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University, Montreal, QC, CanadaAbstract: Corifollitropin alfa is a synthetic recombinant follicle-stimulating hormone (rFSH molecule containing a hybrid beta subunit, which provides a plasma half-life of ∼65 hours while maintaining its pharmocodynamic activity. A single injection of corifollitropin alfa can replace daily FSH injections for the first week of ovarian stimulation for in vitro fertilization. Stimulation can be continued with daily FSH injections if the need arises. To date, more than 2500 anticipated normoresponder women have participated in clinical trials with corifollitropin alfa. It is noteworthy that one-third of women did not require additional gonadotropin injections and reached human chorionic gonadotropin criterion on day 8. The optimal corifollitropin dose has been calculated to be 100 µg for women with a body weight ≤ 60 kg and 150 µg for women with a body weight >60 kg, respectively. Combination of corifollitropin with daily gonadotropin-releasing hormone antagonist injections starting on stimulation day 5 seems to yield similar or significantly higher numbers of oocytes and good quality embryos, as well as similar ongoing pregnancy rates compared with women stimulated with daily rFSH injections. Stimulation characteristics, embryology, and clinical outcomes seem consistent with repeated corifollitropin-stimulated assisted reproductive technologies cycles. Multiple pregnancy or ovarian hyperstimulation syndrome rates with corifollitropin were not increased over daily FSH regimen. The corifollitropin alfa molecule does not seem to be immunogenic and does not induce neutralizing antibody formation. Drug hypersensitivity and injection-site reactions are not increased. Incidence and nature of adverse events and serious adverse events are similar to daily FSH injections. Current trials do not

  5. A Randomized Study of Peginterferon Lambda-1a Compared to Peginterferon Alfa-2a in Combination with Ribavirin and Telaprevir in Patients with Genotype-1 Chronic Hepatitis C.

    Science.gov (United States)

    Flisiak, Robert; Shiffman, Mitchell; Arenas, Juan; Cheinquer, Hugo; Nikitin, Igor; Dong, Yuping; Rana, Khurram; Srinivasan, Subasree

    2016-01-01

    A randomized, double-blind, multinational, phase 3 study was conducted comparing the efficacy and safety of peginterferon lambda-1a (Lambda)/ribavirin (RBV)/telaprevir (TVR) vs. peginterferon alfa-2a (Alfa)/RBV/TVR in patients with chronic hepatitis C virus (HCV) genotype-1 (GT-1) infection. Patients (treatment-naïve or relapsers on prior Alfa/RBV treatment) were randomly assigned in a 2:1 ratio to receive Lambda/RBV/TVR or Alfa/RBV/TVR. Total duration of treatment was either 24 or 48 weeks (response-guided treatment), with TVR administered for the first 12 weeks. The primary endpoint was the proportion of patients who achieved a sustained virologic response at post treatment week 12 (SVR12), which was tested for noninferiority of Lambda/RBV/TVR. A total of 838 patients were enrolled, and 617 were treated; 411 and 206 patients received Lambda/RBV/TVR and Alfa/RBV/TVR, respectively. The majority of patients were treatment-naïve, with HCV GT-1b and a high baseline viral load (≥800,000 IU/mL). Less than 10% of patients had cirrhosis (Lambda, 7.5%; Alfa, 6.8%). Lambda/RBV/TVR did not meet the criterion for noninferiority (lower bound of the treatment difference interval was -12.3%); the SVR12 in all patients (modified intent-to-treat) was 76.2% in the Lambda arm and 82.0% in the Alfa arm. Overall, the frequency of adverse events in each arm was comparable (Lambda, 91.7%; Alfa, 97.1%). As expected based on the safety profile of the 2 interferons, there were more hepatobiliary events observed in the Lambda arm and more hematologic events in the Alfa arm. In this comparison of Lambda/RBV/TVR and Alfa/RBV/TVR in patients who were treatment-naïve or had relapsed on prior Alfa/RBV treatment, Lambda failed to demonstrate noninferiority based on SVR12 results. Treatment with Lambda/RBV/TVR was associated with a higher incidence of relapse. More patients discontinued Lambda/RBV/TVR treatment during the first 4 weeks of study treatment, mainly due to hepatobiliary

  6. Peginterferon Lambda-1a/Ribavirin with Daclatasvir or Peginterferon Alfa-2a/Ribavirin with Telaprevir for Chronic Hepatitis C Genotype 1b.

    Science.gov (United States)

    Flisiak, Robert; Kawazoe, Seiji; Znoyko, Olga; Assy, Nimer; Gadano, Adrian; Kao, Jia-Horng; Lee, Kwan-Sik; Zwirtes, Ricardo; Portsmouth, Simon; Dong, Yuping; Xu, Dong; Kumada, Hiromitsu; Srinivasan, Subasree

    2016-11-01

    The study objective was to compare the efficacy and safety of peginterferon lambda-1a combined with ribavirin/daclatasvir (Lambda/RBV/DCV), versus peginterferon alfa-2a combined with ribavirin/telaprevir (Alfa/RBV/TVR), in patients chronically infected with hepatitis C virus (HCV), genotype 1b. This was a prospective, randomized, open-label, phase 3 study (NCT01718158) in adults (aged ≥18 years) who were treatment naïve or prior relapsers to peginterferon alfa/ribavirin therapy. The primary endpoint was sustained virologic response at post-treatment follow-up week 12 (SVR12). Patients were randomized in a 2:1 ratio to receive 24 weeks of Lambda/RBV/DCV or response-guided 24 or 48 weeks of Alfa/RBV/TVR. Overall, 440 patients were treated (294 with Lambda/RBV/DCV; 146 with Alfa/RBV/TVR). The proportion of patients achieving SVR12 was 88.8% in the Lambda/RBV/DCV arm and 70.5% in the Alfa/RBV/TVR arm (difference between arms: 18.3%; 95% confidence interval: 9.9-25.7; P Lambda/RBV/DCV group had fewer rash-related adverse events (AEs), cytopenic abnormalities, flu-like symptoms, serious AEs, and discontinuations due to AEs, but more liver abnormalities than those in the Alfa/RBV/TVR group. In conclusion, treatment with Lambda/RBV/DCV led to higher SVR12 rates and a more favorable safety profile than Alfa/RBV/TVR in patients with chronic HCV, genotype 1b infection.

  7. The influence of monovalent cations on trimeric G protein Gi1alfa activity in HEK293 cells stably expressing DOR-Gi1alfa (Cys351-Ile351) fusion protein

    Czech Academy of Sciences Publication Activity Database

    Vošahlíková, Miroslava; Svoboda, Petr

    2011-01-01

    Roč. 60, č. 3 (2011), s. 541-547 ISSN 0862-8408 R&D Projects: GA AV ČR(CZ) IAA500110606; GA MŠk(CZ) LC554; GA ČR(CZ) GD305/08/H037 Institutional research plan: CEZ:AV0Z50110509 Keywords : delta-opioid receptor (DOR) * monovalent ions * G(i)1alfa protein Subject RIV: CE - Biochemistry Impact factor: 1.555, year: 2011

  8. Patient evaluation of the use of follitropin alfa in a prefilled ready-to-use injection pen in assisted reproductive technology: an observational study

    Directory of Open Access Journals (Sweden)

    Welcker J

    2010-09-01

    Full Text Available Abstract Background Self-administration of recombinant human follicle-stimulating hormone (r-hFSH can be performed using injection pen devices by women undergoing assisted reproductive technology procedures. The objective of this study was to explore the use of the prefilled follitropin alfa pen in routine assisted reproductive technology procedures in Germany. Methods This prospective, observational study was conducted across 43 German IVF centres over a period of 1.75 years. Patients who had used the prefilled follitropin alfa pen in the current or a previous cycle of controlled ovarian stimulation completed a questionnaire to assess their opinions of the device. Results A total of 5328 patients were included in the study. Of these, 2888 reported that they had previous experience of daily FSH injections. Significantly more patients reported that less training was required to use the prefilled follitropin alfa pen than a syringe and lyophilized powder (1997/3081 [64.8%]; p Conclusions In this questionnaire-based survey, routine use of the prefilled follitropin alfa pen was well accepted and associated with favourable patient perceptions. Users of the pen found it easier to initially learn how to use, and subsequently use, than other injection methods. In general, the prefilled follitropin alfa pen was the preferred method for self-administration of gonadotrophins. Together with previous findings, the results here indicate a high level of patient satisfaction among users of the prefilled follitropin alfa pen for daily self-administration of r-hFSH.

  9. Storm-time slab thickness at low latitudes

    International Nuclear Information System (INIS)

    Chauhan, N.S.; Gurm, H.S.

    1981-01-01

    The ATS-6 data for a period of 1975-76 is used for the study of slab thickness during two moderate storms (Ksub(p) - ) around the crest of the anomaly, Ahmedabad and a very great (Ksub(p) + ) outside the equatorial anomaly region, Delhi. While at Ahmedabad, on the average, the slab thickness is found to be above the frequency. Comparison of slab thickness with foF2 and the equatorial magnetic record (for Ahmedabad only) shows that the foF2 changes alone cannot be held responsible for the slab thickness variation and thus entry of the plasma flux from the plasmasphere cannot be ruled out. The pressure variation effect of storm-time heating on the slab thickness at Ahmedabad is that even for Ksub(p)=8, the thermal expansion and the contraction effects are unable to explain complete quantitative and qualitative features of the observations

  10. Effects of geomagnetic storm on low latitude ionospheric total ...

    Indian Academy of Sciences (India)

    1Department of Physics, Tripura University, Suryamaninagar, Tripura 799 022, India. ... the fact that the electro-dynamic effect of geomagnetic storms around EIA region is more effective than ... causes range of error in GPS communication.

  11. Modeling the 6,300-angstrom low-latitude nightglow

    International Nuclear Information System (INIS)

    Fesen, C.G.; Abreu, V.J.

    1987-01-01

    Observations of the 6,300-angstrom nightglow form the Visible Airglow Experiment (VAE) instrument on AE-E are presented for spring equinox, solar cycle maximum conditions. The data comprise altitude profiles and integrated column brightness maps from ∼1,800 to 0400 LT and within ±30 degrees of the dip equator. The data clearly show near-midnight enhancements of the 6,300-angstrom emission. Attempts to model the column brightness maps indicated that these enhancements are due to tidal effects: the enhancements were only reproduced in the theoretical calculations which included upward propagating tidal components in the neutral winds. Further, low equatorial intensities were observed by the VCAE which could only be simulated by assuming that the phase of the E x B drift by shifted 1 hour LT; i.e., upward drift persists until 2,000 LT instead of 1,900 LT. The VAE observations could be reasonably simulated with the phase shift in the E x B drift and with the dip and geographic equators offset. The major discrepancy is in the magnitude of the nightglow maxima: the calculated intensities are a maximum of 2 times too large. Possible sources are uncertainties in the neutral densities, chemistry, and rate coefficients and in the neutral winds

  12. VHF radar observations of gravity waves at a low latitude

    Directory of Open Access Journals (Sweden)

    G. Dutta

    1999-08-01

    Full Text Available Wind observations made at Gadanki (13.5°N by using Indian MST Radar for few days in September, October, December 1995 and January, 1996 have been analyzed to study gravity wave activity in the troposphere and lower stratosphere. Horizontal wind variances have been computed for gravity waves of period (2-6 h from the power spectral density (PSD spectrum. Exponential curves of the form eZ/H have been fitted by least squares technique to these variance values to obtain height variations of the irregular winds upto the height of about 15 km, where Z is the height in kilometers. The value of H, the scale height, as determined from curve fitting is found to be less than the theoretical value of scale height of neutral atmosphere in this region, implying that the waves are gaining energy during their passage in the troposphere. In other words, it indicates that the sources of gravity waves are present in the troposphere. The energy densities of gravity wave fluctuations have been computed. Polynomial fits to the observed values show that wave energy density increases in the troposphere, its source region, and then decreases in the lower stratosphere.Key words. Meteorology and atmospheric dynamics (middle atmosphere dynamics; turbulence; waves and tides

  13. Letter to the Editor: Geomagnetic storm effects at low latitudes

    Directory of Open Access Journals (Sweden)

    R. G. Rastogi

    Full Text Available The geomagnetic horizontal (H field from the chain of nine observatories in India are used to study the storm-time and disturbance daily variations. The peak decrease in storm-time variation in H showed significant enhancements at the equatorial electrojet stations over and above the normally expected decrease due to the ring current effects corrected for geomagnetic latitudes. The disturbance daily variation of H at equatorial stations showed a large decrease around midday hours over and above the usual dawn-maximum and dusk-minimum seen at any mid-latitude stations around the world. These slow and persistent additional decreases of H of disturbance daily variation at equatorial latitudes could be the effect of a westward electric field due to the Disturbance Ionospheric dynamo coupled with abnormally large electrical conductivities in the E region over the equator.Key words. Ionosphere (electric fields and currents · Magnetospheric physics (electric fields; storms and substorms

  14. Letter to the Editor: Geomagnetic storm effects at low latitudes

    Directory of Open Access Journals (Sweden)

    R. G. Rastogi

    1999-03-01

    Full Text Available The geomagnetic horizontal (H field from the chain of nine observatories in India are used to study the storm-time and disturbance daily variations. The peak decrease in storm-time variation in H showed significant enhancements at the equatorial electrojet stations over and above the normally expected decrease due to the ring current effects corrected for geomagnetic latitudes. The disturbance daily variation of H at equatorial stations showed a large decrease around midday hours over and above the usual dawn-maximum and dusk-minimum seen at any mid-latitude stations around the world. These slow and persistent additional decreases of H of disturbance daily variation at equatorial latitudes could be the effect of a westward electric field due to the Disturbance Ionospheric dynamo coupled with abnormally large electrical conductivities in the E region over the equator.Key words. Ionosphere (electric fields and currents · Magnetospheric physics (electric fields; storms and substorms

  15. Low-latitude ionospheric turbulence observed by Aureol-3 satellite

    Directory of Open Access Journals (Sweden)

    Y. Hobara

    2005-06-01

    Full Text Available Using PSD (Power Spectral Density data on electron density and electric field variations observed on board Aureol-3 satellite at low-to-mid-latitude ionosphere we analyze a scale distribution of the ionospheric turbulence in a form k, where k is the wave number and α is the spectral index. At first, high-resolution data in the near-equator region for several orbits have been processed. In this case the frequency range is from 6Hz to 100Hz (corresponding spatial scales from 80m to 1.3km, each power spectrum obeys a single power law fairly well, and the mean spectral indices are rather stable with αN=2.2±0.3 and αE=1.8±0.2, for the density and electric field, respectively. Then we produce a statistical study of 96 electric field bursts in the frequency range 10-100Hz from low-time resolution data (filter bank envelope. These bursts concentrate on the side of the Equatorial Anomaly crest (geomagnetic latitude 30-40°. Spectral indices of the bursts vary in the interval αE=2.0-2.5 but are fairly stable in seasons and local times. The electric field power of the burst has rather a large variability but has a relative increase in mean values for the summer and winter, as well as the daytime. The effect of major seismic activities toward the ionospheric turbulence is not conclusive either for the refractive index or for the electric field power. However, the mean value for the electric field power of bursts during seismic periods is larger than that for non seismic periods, and the statistical difference of the mean values is rather significant.

  16. Low-latitude ionospheric turbulence observed by Aureol-3 satellite

    Directory of Open Access Journals (Sweden)

    Y. Hobara

    2005-06-01

    Full Text Available Using PSD (Power Spectral Density data on electron density and electric field variations observed on board Aureol-3 satellite at low-to-mid-latitude ionosphere we analyze a scale distribution of the ionospheric turbulence in a form k-α, where k is the wave number and α is the spectral index. At first, high-resolution data in the near-equator region for several orbits have been processed. In this case the frequency range is from 6Hz to 100Hz (corresponding spatial scales from 80m to 1.3km, each power spectrum obeys a single power law fairly well, and the mean spectral indices are rather stable with αN=2.2±0.3 and αE=1.8±0.2, for the density and electric field, respectively. Then we produce a statistical study of 96 electric field bursts in the frequency range 10-100Hz from low-time resolution data (filter bank envelope. These bursts concentrate on the side of the Equatorial Anomaly crest (geomagnetic latitude 30-40°. Spectral indices of the bursts vary in the interval αE=2.0-2.5 but are fairly stable in seasons and local times. The electric field power of the burst has rather a large variability but has a relative increase in mean values for the summer and winter, as well as the daytime. The effect of major seismic activities toward the ionospheric turbulence is not conclusive either for the refractive index or for the electric field power. However, the mean value for the electric field power of bursts during seismic periods is larger than that for non seismic periods, and the statistical difference of the mean values is rather significant.

  17. Wavelet Statistical Analysis of Low-Latitude Geomagnetic Measurements

    Science.gov (United States)

    Papa, A. R.; Akel, A. F.

    2009-05-01

    Following previous works by our group (Papa et al., JASTP, 2006), where we analyzed a series of records acquired at the Vassouras National Geomagnetic Observatory in Brazil for the month of October 2000, we introduced a wavelet analysis for the same type of data and for other periods. It is well known that wavelets allow a more detailed study in several senses: the time window for analysis can be drastically reduced if compared to other traditional methods (Fourier, for example) and at the same time allow an almost continuous accompaniment of both amplitude and frequency of signals as time goes by. This advantage brings some possibilities for potentially useful forecasting methods of the type also advanced by our group in previous works (see for example, Papa and Sosman, JASTP, 2008). However, the simultaneous statistical analysis of both time series (in our case amplitude and frequency) is a challenging matter and is in this sense that we have found what we consider our main goal. Some possible trends for future works are advanced.

  18. Low-latitude ice cores and freshwater availability

    Science.gov (United States)

    Kehrwald, Natalie Marie

    2009-12-01

    Recent retreat of Tibetan Plateau glaciers affects at least half a billion people. Himalayan glaciers seasonally release meltwater into tributaries of the Indus, Ganges, and Brahmaputra Rivers and supply freshwater necessary to support agricultural and economic practices. Tibetan Plateau glaciers are retreating more rapidly than mountain glaciers elsewhere in the world, and this retreat is accelerating. The Naimona'nyi (30°27'N; 81°91'E, 6050 m a.s.l), Guliya (35°17'N; 81°29'E, 6710 m a.s.l.) and Dasuopu (28°23'N; 85°43'E, 7200 m a.s.l.) ice cores place this recent retreat into a longer time perspective through quantifying climate parameters such as past temperature, aridity, and atmospheric chemistry. Naimona'nyi has not accumulated mass since at least 1950, as evidenced by the virtual lack of radiogenic isotopes (36Cl, 3 H, and beta radioactivity) present in the ice core. These isotopes were produced by U.S. and Soviet atmospheric thermonuclear bomb tests conducted in the 1950s and 1960s and provide independent dating horizons for the ice cores. Lead-210 dates imply that the uppermost preserved glacial ice on Naimona'nyi formed during the 1940s. While this is the highest documented glacial thinning in the world other glaciers at elevations similar to that of Naimona'nyi, such as Kilimanjaro (3°4'S; 37°21'E, 5893 m a.s.l.), are also losing mass at their summits. The global scope of high-elevation glacial thinning suggests that ablation on the Earth's highest ice fields may be more prevalent as global mean temperatures continue to increase. Glacial thinning has not been taken into account in future projections of regional freshwater availability, and the net mass loss indicates that Himalayan glaciers currently store less freshwater than assumed in models. The acceleration of Tibetan Plateau glacial retreat has been hypothesized to be due in part to deposition of black carbon (BC) from biomass burning on to ice fields, thereby lowering the reflectivity of the glacier surface and melting the upper ice. The application of a novel technique of measuring and radiocarbon-dating ultra-small samples (Peru (13'56'S; 70°50'W; 5670 m a.s.l.). A marked increase in modern BC and TOC was measured since 1880 AD. No increase in radiocarbon-dead (> 60,000 ka) BC or TOC was noted, suggesting that the source of the carbon was from biomass burning, with a possible contribution of Amazon slash and burn clearing, rather than the input of fossil fuel combustion. The age of the BC and TOC is thousands of years older than the age of the surrounding ice, and should not be used to date the ice core. Although Naimona'nyi provides challenges for constructing an ice core chronology due to its lack of independent horizons such as volcanic activity, methane gas measurements, 14C dates, 3H, 36Cl, or beta radioactivity, the oxygen isotopic record can be correlated with the neighboring Dasuopu and Guliya ice cores. Naimona'nyi contains a pronounced positive ˜10‰ shift in delta18O in the basal 37 m of the core which mimics similar isotopic shifts in regional speleothems, lacustrian sediments, and planktonic foraminifera proxy records. This distinct shift is attributed to amplified monsoon intensity caused by increased summer insolation at 30°N. This correlation between regional proxy records results in a basal age of ˜8.6 ka for Naimona'nyi, suggesting that the ice field grew as a response to tropical rather than polar climate forcings.

  19. Dynamics of the low latitude thermosphere and ionosphere

    International Nuclear Information System (INIS)

    Burnside, R.G.

    1984-01-01

    Nighttime thermospheric neutral wind velocities were determined at Arecibo, Puerto Rico, by using a Fabry-Perot interferometer, which measures the Doppler shift of the O( 1 D) airglow emission. In summer, the winds are observed to flow toward the southeast between sunset and midnight. After midnight in summer, the meridional component of the wind usually slackens, while the zonal component may reverse. By contrast, in winter, the meridional wind is often small, and the predominant flow is eastward throughout the night. Vertical winds are inferred from the divergence of the horizontal flow. A maximum downward flow of about 5 m sπ 1 is observed near midnight in summer. Incoherent scatter radar measurements were used to calculate the O + diffusion velocity and infer the vertical profile of the meridional wind. Horizontal temperature gradients and ion-drag forces were evaluated from radar measurements. It is concluded that it may sometimes be necesary to include viscous forces to balance the meridional equation of motion for the neutral gas. Electrical conductivities of the E and F layers of the nighttime ionosphere were determined. The F layer Pedersen conductivity at the magnetically conjugate point was evaluated using ionosonde data. The F layer dynamo mechanism was found to be the source of most of the nighttime electric fields observed at Arecibo

  20. Low-latitude ionospheric disturbances associated with earthquakes

    Energy Technology Data Exchange (ETDEWEB)

    Depueva, A.; Rotanova, N. [Russian Academy of Sciences, Inst. of Terrestrial Magnetism, Ionosphere and Radio Wave Propagation, Moscow (Russian Federation)

    2001-04-01

    Topside electron density measured on satellite board was analysed. It was shown that before the two considered earthquakes with their epicenters located at low and equatorial latitudes the stable modification of the ionosphere both at and above the height of the F-layer peak was observed. Electron density gradually decreased and its spatial distribution looked like a funnel located either immediately over the epicenter or from its one side. Electron density irregularities of 300-500 km size in a meridional direction also occurred side by side with aforesaid background large-scale depletions. For detection of local structures of more than 1000 km extent, the method of natural orthogonal component expansion was applied; spectra of smaller scale inhomogeneities were investigated by means of the Blackman-Tukey method. A proposal is made for observed experimental data interpretation.

  1. Ionosonde observations of daytime spread F at low latitudes

    Science.gov (United States)

    Jiang, Chunhua; Yang, Guobin; Liu, Jing; Yokoyama, Tatsuhiro; Komolmis, Tharadol; Song, Huan; Lan, Ting; Zhou, Chen; Zhang, Yuannong; Zhao, Zhengyu

    2016-12-01

    Spread F on ionograms has been considered to be a phenomenon mainly occurred at nighttime. This study presented a case study of daytime spread F observed by the ionosonde installed at Puer (PUR; 22.7°N, 101.05°E; dip latitude 12.9°N), where daytime spread F that lasted for more than 2 h (about 08:30 LT 10:45 LT) was observed on 14 November 2015. To investigate the possible mechanism, ionograms recorded at PUR and Chiang Mai (18.76°N, 98.93°E; dip latitude 9.04°N) were used in this study. We found that traveling ionospheric disturbances were observed before the occurrence of daytime spread F. Meanwhile, the movement of the peak height of the ionosphere was downward. We suggested that downward vertical neutral winds excited by traveling atmospheric disturbances/atmospheric gravity waves might play a significant role in forming daytime spread F over PUR during geomagnetic storms.

  2. Low latitude electron temperature observed by the CHAMP satellite

    DEFF Research Database (Denmark)

    Stolle, Claudia; Truhlik, V.; Richards, P.

    2012-01-01

    Te morning overshoot (MO). Both, data and model revealed an anti-correlation between the equatorial MO amplitude and solar EUV flux at these altitudes. The CHAMP observations also reveal a post sunset electron temperature anomaly in analogy to the equatorial ionisation anomaly at altitudes below 400...

  3. Ionospheric irregularities at low latitudes in the American sector

    International Nuclear Information System (INIS)

    Nakamura, Y.

    1981-10-01

    A detailed analysis of the atomic oxigem airglow emission at the wavelength of 6300 A observed at Cachoeira Paulista (22 0 41'S, 45 0 00'W) shows that intensity perturbations frequently occur and propagate from north to south and from west to east. Such irregularities originated in the ionospheric F region and occur essencially during the premidnight period. These perturbations have a high frequency of occurrence during spring and summer and are rare during winter and fall. The disturbances are correlated with range type spread F detected over Cachoeira Paulista, and have characteristics similar to equatorial ionospheric plasma bubbles (i.e., similar seazonal variation, time of occurrence, ionogram signatures, direction and speed of propagation, etc.). A numerical simulation is carried out for the generation and evolution of ionospheric bubbles based on the theory of the collisional Rayleigh-Taylor instability for the equatorial and Cachoeira Paulista regions. Also a study was made of the, evolution of the bubble as a function of the electron density profile and as a function of the amplitude of the initial density perturbation. Assuming the electron density profile perturbed by the bubble, the [OI] 6300 A intensity was calculated for various latitudes arbitrarily taken within the photometer scanning range. The bubble was assumed to be aligned with the Earth's magnetic field and extending from higher altitudes at the equatorial region down to be arbitrary height of 150 Km at which a negligible conductivity is assumed. It was also assumed that the bubble was moving upwards with the velocity of 120 m/s, which in turn was estimated from initial numerical simulation results. The airglow calculation results show that as the bubble goes up, the disturbances in the airglow intensity propagate from north to south, in accord with observed experimental results. (Author) [pt

  4. Structure of the low-latitude boundary layer

    International Nuclear Information System (INIS)

    Sckopke, N.; Paschmann, G.; Haerendel, G.; Sonnerup, B.U.O.; Bame, S.J.; Forbes, T.G.; Hones, E.W. Jr.; Russell, C.T.

    1981-01-01

    Observations at high temporal resolution of the frontside magnetopause and plasma boundary layer, made with the Los Alamos Scientific Laboratory/Max-Planck-Institut, Institut fuer Extraterrestrische Physik, fast plasma analyzer on board the Isee 1 and 2 spacecraft, have revealed a complex quasi-periodic structure of some of the observed boundary layers: cool tailward streaming boundary layer plasma is seen intermittently, with intervening periods of hot tenuous plasma which has properties similar to the magnetospheric population. While individual encounters with the boundary layer plasma last only a few minutes, the total observation time may extend over 1 hour or more. One such crossing, at 0800 hours local time and 40 0 northern GSM latitude, is examined in detail, including a quantitative comparison of the boundary layer entry and exit times of the two spacecraft. The data are found to be compatible with a boundary layer that is always attached to the magnetopause but where the layer thickness has a large-scale spatial modulation pattern which travels tailward past the spacecraft. Included are periods when the thickness is essentially zero and others when it is of the order of 1 R/sub E/. The duration of these periods is highly variable but is typically in the range of 2--5 min, corresponding to a distance along the magnetopause of the order of 3--8 R/sub E/. The observed boundary layer features include a steep density gradient at the magnetopause, with an approximately constant boundary layer plasma density amounting to about 25% of the magnetosheath density, and a second abrupt density decrease at the inner edge of the layer. It also appears that the purely magnetospheric plasma is ocassionally separated from the boundary layer by a halo region in which the plasma density is somewhat higher, and the temperature somewhat lower, than in the magnetosphere. A tentative model is proposed

  5. Modeling the Electrodynamics of the Low-Latitude Ionosphere

    National Research Council Canada - National Science Library

    Wohlwend, Christian S

    2008-01-01

    .... This two-part study focused on the gravity wave seeding mechanism of equatorial plasma depletions in the ionosphere and the associated-equatorial spread F, as well as the differences between a two...

  6. Characteristics of low latitude ionospheric E-region irregularities ...

    Indian Academy of Sciences (India)

    154°E, dip angle = 37.3°, sub-ionospheric dip = 34°) have been analyzed to study the behaviour of ionospheric E-region irregularities during the active solar and magnetic periods. The autocorrelation functions, power spectral densities, signal de-correlation times are computed to study the temporal features of ionospheric ...

  7. EFFECTIVENESS AND SAFETY OF VELAGLUCERASE ALFA IN TREATMENT OF GAUCHER DISEASE TYPE 1 (ACCORDING TO INTERNATIONAL STUDIES

    Directory of Open Access Journals (Sweden)

    O. S. Gundobina

    2014-01-01

    Full Text Available The article is dedicated to modern approaches to treatment of Gaucher’s disease. The authors list the primary aspects of the disease and present data on the origin and introduction of pathogenetic enzyme replacement therapy to clinical practice. Review of international clinical studies demonstrates high effectiveness and safety of long-term enzyme replacement therapy with velaglucerase alfa in patients with confirmed type I Gaucher’s disease. 

  8. Impact of weight-based ribavirin with peginterferon alfa-2b in African Americans with hepatitis C virus genotype 1.

    Science.gov (United States)

    Jacobson, Ira M; Brown, Robert S; McCone, Jonathan; Black, Martin; Albert, Clive; Dragutsky, Michael S; Siddiqui, Firdous A; Hargrave, Thomas; Kwo, Paul Y; Lambiase, Louis; Galler, Greg W; Araya, Victor; Freilich, Bradley; Harvey, Joann; Griffel, Louis H; Brass, Clifford A

    2007-10-01

    WIN-R (Weight-based dosing of pegINterferon alfa-2b and Ribavirin) was a multicenter, randomized, open-label, investigator-initiated trial involving 236 community and academic sites in the United States, comparing response to pegylated interferon (PEG-IFN) alfa-2b plus a flat or weight-based dose of ribavirin (RBV) in treatment-naive patients with chronic hepatitis C and compensated liver disease. Patients were randomized to receive PEG-IFN alfa-2b at 1.5 microg/kg/week plus flat-dose (800 mg/day) or weight-based-dose RBV (800 mg/day for weight 85-105 kg, or 1400 mg/day for >105- or =65 kg was the primary end point. Low SVR rates have been reported among African American individuals, in whom there is a preponderance of HCV genotype 1. This subanalysis of WIN-R was conducted to evaluate the efficacy of weight-based dosing among African American individuals with genotype 1 infection enrolled in the trial. Of 362 African American patients in the primary efficacy analysis, 188 received RBV flat dosing and 174 received weight-based dosing. SVR rates were higher (21% versus 10%; P = 0.0006) and relapse rates were lower (22% versus 30%) in the weight-based-dose group than in the flat-dose group. Safety and rates of drug discontinuation were similar between the 2 groups. Weight-based dosing of RBV is more effective than flat dosing in combination with PEG-IFN alfa-2b in African American individuals with HCV genotype 1. Even with weight-based dosing, response rates in African American individuals are lower than reported in other ethnic groups.

  9. Surface displaced alfa-enolase of Lactobacillus plantarum is a fibronectin binding protein

    Directory of Open Access Journals (Sweden)

    Muscariello Lidia

    2009-02-01

    Full Text Available Abstract Background Lactic acid bacteria of the genus Lactobacillus and Bifidobacterium are one of the most important health promoting groups of the human intestinal microbiota. Their protective role within the gut consists in out competing invading pathogens for ecological niches and metabolic substrates. Among the features necessary to provide health benefits, commensal microorganisms must have the ability to adhere to human intestinal cells and consequently to colonize the gut. Studies on mechanisms mediating adhesion of lactobacilli to human intestinal cells showed that factors involved in the interaction vary mostly among different species and strains, mainly regarding interaction between bacterial adhesins and extracellular matrix or mucus proteins. We have investigated the adhesive properties of Lactobacillus plantarum, a member of the human microbiota of healthy individuals. Results We show the identification of a Lactobacillus plantarum LM3 cell surface protein (48 kDa, which specifically binds to human fibronectin (Fn, an extracellular matrix protein. By means of mass spectrometric analysis this protein was identified as the product of the L. plantarum enoA1 gene, coding the EnoA1 alfa-enolase. Surface localization of EnoA1 was proved by immune electron microscopy. In the mutant strain LM3-CC1, carrying the enoA1 null mutation, the 48 kDa adhesin was not anymore detectable neither by anti-enolase Western blot nor by Fn-overlay immunoblotting assay. Moreover, by an adhesion assay we show that LM3-CC1 cells bind to fibronectin-coated surfaces less efficiently than wild type cells, thus demonstrating the significance of the surface displaced EnoA1 protein for the L. plantarum LM3 adhesion to fibronectin. Conclusion Adhesion to host tissues represents a crucial early step in the colonization process of either pathogens or commensal bacteria. We demonstrated the involvement of the L. plantarum Eno A1 alfa-enolase in Fn-binding, by studying

  10. The pharmacokinetics of a B-domain truncated recombinant factor VIII, turoctocog alfa (NovoEight®), in patients with hemophilia A.

    Science.gov (United States)

    Jiménez-Yuste, V; Lejniece, S; Klamroth, R; Suzuki, T; Santagostino, E; Karim, F A; Saugstrup, T; Møss, J

    2015-03-01

    Turoctocog alfa (NovoEight(®)) is a human recombinant coagulation factor VIII (rFVIII) for the treatment of patients with hemophilia A. To evaluate the pharmacokinetics of turoctocog alfa in all age groups across clinical trials. Data from previously treated patients with severe hemophilia A (FVIII activity level of ≤ 1%) with no history of FVIII inhibitors, in a non-bleeding state, were included. The pharmacokinetics were assessed following a wash-out period and a subsequent single intravenous 50 IU kg(-1) dose of turoctocog alfa. Blood was sampled during a 48-h period postdose. Standard pharmacokinetic (PK) parameters were estimated on the basis of plasma FVIII activity vs. time (PK profiles) with non-compartmental methods. Furthermore, a population PK analysis was conducted. Data from 76 patients (aged 1-60 years) enrolled globally across six clinical trials were included, totaling 105 turoctocog alfa PK profiles. Single-dose PK results 3-6 months after the first dose of turoctocog alfa were comparable with the results obtained after the first dose. Similar PK characteristics were shown for different lots and strengths of the drug product. Overall, area under the plasma concentration (activity) curve from administration to infinity (AUC) and t1(/2) tended to increase with increasing age, with lower AUC and shorter t(1/2) being seen in children than in adolescents and adults. The PK profiles of turoctocog alfa and other commercially available plasma-derived FVIII and rFVIII products were similar in all age groups. The PK characteristics of turoctocog alfa have been thoroughly studied, and shown to be consistent over time, reproducible between different lots and strengths of drug product, and similar to those observed for other FVIII products. © 2014 International Society on Thrombosis and Haemostasis.

  11. Development of solar energy education IASEE-Argentina, Arquisur and Alfa-built

    International Nuclear Information System (INIS)

    Schiller, S. de; Evans, J.M.

    1997-01-01

    Three educational experiences are presented in this paper on the development of national and regional networks to incorporate renewable energy in curricular programmes. IASEE-Argentina, established in 1990 as the National Section of IASEE, the International Association for Solar Energy Education, was designated in 1993 as the Education Working Group of ASADES, the Argentine Association of Solar Energy. It holds annual meetings to coincide with the ASADES conference. Arquisur is a regional network established by Architectural Faculties of State Universities within the Mercosur Region, covering Argentina, southern Brazil, Paraguay and Uruguay, to promote exchange and development between the 19 faculties involved. A Working Group set up by Arquisur with members from four countries developed the programme for short post-graduate courses on bioclimatic design and rational energy use in buildings, which has been given in Argentina and Uruguay. Alfa-Built, a project supported by the European Union for promoting academic exchange in the field of energy efficient building is also introduced. This paper presents the development and initial results of these educational experiences. (author)

  12. Characterization of autoantibodies in autoimmune hemolytic anemia following treatment with interferon alfa

    International Nuclear Information System (INIS)

    Bencomo Hernandez, Antonio; Gutierrez Diaz, Adys; Avila Cabrera, Onel; Rodriguez, Luis Ramon

    2012-01-01

    We studied 13 patients with chronic myeloid leukemia and autoimmune hemolytic anemia induced by interferon alfa. They underwent tests for immune protein detection and characterization of IgG subclasses in RBCs by direct antiglobulin test (PAD) and the microplate technique. Also they were applied ELISA test for quantifying immunoglobulins in the red blood cells. It was detected the presence of IgG and C3 in 53.84 % of cases, IgG alone in 23.07 % and in 15.38 % were identified IgG and IgA autoantibodies. In 11 patients the presence of IgG1 was showed and also in one case the subclass IgG3 autoantibodies was identified. The ELISA detected antibodies at concentrations of 183 IgG molecules per erythrocyte in a patient with negative PAD. In high-grade hemolysis patients, it was found a concentration of autoantibodies between 1 500 and 3 180 molecules of IgG per erythrocyte, while in low-grade hemolysis patients it behaved between 183 and 1 000 molecules. There was a negative correlation between Hb and plasma haptoglobin values with the number of IgG molecules per erythrocyte and a positive correlation between the latter with the reticulocyte count

  13. Acute pancreatitis attributed to the use of interferon alfa-2b.

    Science.gov (United States)

    Eland, I A; Rasch, M C; Sturkenboom, M J; Bekkering, F C; Brouwer, J T; Delwaide, J; Belaiche, J; Houbiers, G; Stricker, B H

    2000-07-01

    Two patients experienced episodes of acute pancreatitis shortly after starting treatment with interferon alfa-2b (IFN-alpha) for a chronic hepatitis C infection. The first patient was a 40-year-old man who developed acute pancreatitis after 15 weeks of treatment with 3 MU IFN-alpha subcutaneously (SC) 3 times weekly and 1200 mg ribavirin. After disappearance of symptoms and normalization of laboratory values, oral intake of solid foods and IFN-alpha therapy were restarted. Within hours, a relapse of acute pancreatitis occurred. A rechallenge with IFN-alpha 4 days later was followed by a prompt increase in serum lipase level, and IFN-alpha therapy was discontinued. The second patient was a 38-year-old man who developed acute pancreatitis 2 hours after SC administration of 5 MU IFN-alpha. Ultrasound endoscopy showed sludge in the gallbladder. The patient was rechallenged 5 weeks later with 3 MU IFN-alpha SC. Although serum amylase and lipase levels increased after readministration of IFN-alpha, treatment was continued. The patient was readmitted 2 weeks later with severe abdominal pain, and IFN-alpha administration was discontinued. Considering the temporal relationship between the start of IFN-alpha treatment and development of acute pancreatitis, the absence of other clear etiologic factors for acute pancreatitis, disappearance of symptoms after discontinuation of IFN-alpha, and positive reactions to rechallenge, IFN-alpha is the most probable cause for development of acute pancreatitis in these patients.

  14. LHC Report: special run with de-squeezed beams for ATLAS/ALFA and TOTEM

    CERN Multimedia

    Helmut Burkhardt for the LHC team

    2015-01-01

    The main high-luminosity proton-proton run of the LHC is complemented by one week per year of special proton-proton runs. The special runs are performed with larger beam sizes at the interaction points to allow the forward physics experiments, TOTEM and ATLAS/ALFA, the chance to make precise measurements of protons as they emerge from collisions at small angles.   In standard high-luminosity operation, the beams are squeezed to give small beam sizes at the interaction points to maximise the collision rates. The “squeeze” takes place at top energy and the beam size at the centre of ATLAS (IP1) and CMS (IP5) is reduced from 66 micrometres at the top of the ramp to 18 micrometres before colliding beams are established. Protons that avoid the fate of an inelastic collision but yet still interact – in elastic or diffractive events – are scattered and emerge in the forward direction. The reduction in beam size has a side effect of increasing the an...

  15. Reversing anticoagulant effects of novel oral anticoagulants: role of ciraparantag, andexanet alfa, and idarucizumab

    Directory of Open Access Journals (Sweden)

    Hu TY

    2016-02-01

    Full Text Available Tiffany Y Hu,1 Vaibhav R Vaidya,2 Samuel J Asirvatham2,31Mayo Medical School, 2Division of Cardiovascular Diseases, Department of Internal Medicine, 3Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, MN, USAAbstract: Novel oral anticoagulants (NOACs are increasingly used in clinical practice, but lack of commercially available reversal agents is a major barrier for mainstream use of these therapies. Specific antidotes to NOACs are under development. Idarucizumab (aDabi-Fab, BI 655075 is a novel humanized mouse monoclonal antibody that binds dabigatran and reverses its anticoagulant effect. In a recent Phase III study (Reversal Effects of Idarucizumab on Active Dabigatran, a 5 g intravenous infusion of idarucizumab resulted in the normalization of dilute thrombin time in 98% and 93% of the two groups studied, with normalization of ecarin-clotting time in 89% and 88% patients. Two other antidotes, andexanet alfa (PRT064445 and ciraparantag (PER977 are also under development for reversal of NOACs. In this review, we discuss commonly encountered management issues with NOACs such as periprocedural management, laboratory monitoring of anticoagulation, and management of bleeding. We review currently available data regarding specific antidotes to NOACs with respect to pharmacology and clinical trials.Keywords: novel oral anticoagulant, dabigatran, idarucizumab, reversal

  16. LONG TERM MUCOLYTIC THERAPY WITH DORNASE ALFA AT NOVOSIBIRSK CENTER FOR DIAGNOSTICS, TREATMENT, RHEABILITATION AND ADAPTATION OF CHILDREN WITH CYSTIC FIBROSIS

    Directory of Open Access Journals (Sweden)

    N.I. Romanenko

    2006-01-01

    Full Text Available The center for diagnostic, treatment, rehabilitation and social adaptation of patients with cystic fibrosis was established in pulmonology department of the children's clinical hospital № 3 of Novosibirsk in 1994. Since 1995 the database of the center has registered 23 patients. the center has carried out an open prospective study of clinical efficacy and safety of dornase alfa (pulmozyme, «F. hoffmannala roche ltd.», basel in 10 patients with cystic fibrosis. The patients have received mucolytic therapy with dornase alfa for 2 years (2003–2005. They have been administered a daily inhalation of 2.5 ml of the solution (pulmozyme inhalation solution containing 2.5 of dornaza alfa. The study has shown an improvement of pulmonary function and elevation of oxygen saturation. The number of respiratory infections have dropped by 33%, the administration of intravenous antibiotics has shortened by 25%, the nutrition status has trended towards improvement. regardless of it's high price, dornasa alfa has proven its' benefits in the treatment of cystic fibrosis in patients of any age and disease severity.Key words: dornase alfa, children, cystic fibrosis, treatment.

  17. Autoantibodies to alfa-fodrin in patients with Hashimoto thyroiditis and Sjögren's syndrome: possible markers for a common secretory disorder.

    Science.gov (United States)

    Szanto, Antonia; Csipo, Istvan; Horvath, Ildiko; Biro, Edit; Szodoray, Peter; Zeher, Margit

    2008-09-01

    Presence of autoantibodies to alfa-fodrin was investigated in patients with Sjögren's syndrome (n = 61), Hashimoto thyroiditis (n = 27), Sjögren's syndrome associated with Hashimoto thyroiditis (n = 31) and in healthy persons (n = 77). In each group, level of alfa-fodrin antibodies was higher than in the controls. There was no significant difference in their presence either between patients with Hashimoto thyroiditis with or without Sjögren's syndrome, or-in IgA isotype-between Sjögren's and Hashimoto thyroiditis patients. Correlation was found between the level of IgG alfa-fodrin and anti-thyroglobulin antibodies. Based on these findings, fodrin can be associated with both endocrine and exocrine glandular secretion. Antibodies to alfa-fodrin might have a role in the pathogenesis of Hashimoto thyroiditis concerning the "final common effectory pathway", secretion. Alfa-fodrin antibodies can be good markers of secretory disorders. Assessment of these autoantibodies might help the diagnosis and follow-up of patients with impaired secretory capability of not only autoimmune origin.

  18. Análise comparativa do controle interno no contas a receber e a pagar nas empresas Beta Ltda e Alfa Ltda = A comparative internal control analysis of receivable and payable accounts in Beta and Alfa Ltd Companies

    Directory of Open Access Journals (Sweden)

    Cleyton de Oliveira Ritta

    2010-07-01

    Full Text Available A necessidade constante de um excelente desempenho empresarial leva à busca da qualidade e confiabilidade da informação para o auxílio na tomada de decisão. Neste contexto, a auditoria contábil tem um papel importante na análise das práticas administrativas adotadas pelas entidades. Desse modo, o objetivo deste artigo é comparar a estruturação dos controles internos no contas a receber e a pagar nas empresas Beta Ltda, a qual não contrata serviços de auditoria externa, e Alfa Ltda, que os contrata. Este estudo caracteriza-se como de caso comparativo de caráter descritivo por meio de questionário e entrevista. Os resultados apontam que a empresa Alfa Ltda tem melhores níveis de controle interno e, consequentemente, está menos exposta a erros e fraudes. Desse modo, entende-se que os seviços de auditoria atuam como um instrumento de auxílio para minimização dos riscos operacionais e servem de alerta aos gestores quanto à eficiência das transações. Contudo, percebe-se que a qualidade dos controles internos nas organizações depende diretamente da utilização de procedimentos de monitoramento.The constant need for excellent business performance triggers the quest for information quality and reliability to help in decision making. Considering this context, accounting auditing plays an important role in the analysis of administrative practices adopted by entities. Thus, the objective of this article is to compare the structure of the internal controls for receivable and payable accounts in Beta Ltd companies, which do not contract external auditing services, and Alfa Ltd, which does. This study is a descriptive comparative case study, carried out through questionnaire and interview. The results have showed that Alfa Ltd has better internal control levels and consequently is less exposed to errors and fraud. This way, auditing services are seen as auxiliary instruments to minimize operational risks and serve to alert

  19. Boosting of antioxidant defence by interferon -Alfa in irradiated bone marrow transplanted rats

    International Nuclear Information System (INIS)

    Ashry, O.M.; Hussein, E.M.; Salama, S.F.

    2009-01-01

    this work was conducted to point out the influence of the biological responses modifiers namely interferon-Alfa (IFN-α)and bone marrow transplantation (BMT)on boosting the antioxidant level and protection from oxidative stress in irradiated rats. BMT was given to male rats, 3 hours post gamma irradiation at the dose level pf 5 Gy, that were injected intra peritoneal with 30,000 units of crude mouse virus-induced IFN-α biweekly for 2 months. glutathione (GSH) has a significant role in cell protection from oxidative stress. excessive lipid peroxidation can cause increased GSH consumption, thus the content of GSH was measured in blood, liver, lung and spleen tissues. product of lipid peroxidation (MDA)was measured in parallel. serum total lipids, cholesterol as well as blood parameters as white blood cells (WBCS), erythrocytes count (RBCs), hemoglobin content (Hb) and hematocrit value (Hct % ) were monitored. results point out that all investigated blood parameters were significantly elevated, while MDA was depressed in serum and spleen by BMT alone after 2 months. irradiation significantly depressed all investigated blood parameters, GSH of different tissues and conversely elevated level of lipid peroxidation, total lipids and cholesterol. WBCs, RBCs, Hb,Ht, blood GSH and serum MDA of of irradiated animals receiving BMT were normalized and exhibited significant differences compared to the irradiated group . IFN-α combined with BMT reconstituted blood parameters, normalized blood GSH and MDA and significantly elevated tissue GSH concentration and depressed tissue MDA as well as serum total lipids and cholesterol, compared to the irradiated group

  20. Comparative therapeutic effects of velaglucerase alfa and imiglucerase in a Gaucher disease mouse model.

    Directory of Open Access Journals (Sweden)

    You-Hai Xu

    2010-05-01

    Full Text Available Gaucher disease type 1 is caused by the defective activity of the lysosomal enzyme, acid beta-glucosidase (GCase. Regular infusions of purified recombinant GCase are the standard of care for reversing hematologic, hepatic, splenic, and bony manifestations. Here, similar in vitro enzymatic properties, and in vivo pharmacokinetics and pharmacodynamics (PK/PD and therapeutic efficacy of GCase were found with two human GCases, recombinant GCase (CHO cell, imiglucerase, Imig and gene-activated GCase (human fibrosarcoma cells, velaglucerase alfa, Vela, in a Gaucher mouse, D409V/null. About 80+% of either enzyme localized to the liver interstitial cells and <5% was recovered in spleens and lungs after bolus i.v. injections. Glucosylceramide (GC levels and storage cell numbers were reduced in a dose (5, 15 or 60 U/kg/wk dependent manner in livers (60-95% and in spleens ( approximately 10-30%. Compared to Vela, Imig (60 U/kg/wk had lesser effects at reducing hepatic GC (p = 0.0199 by 4 wks; this difference disappeared by 8 wks when nearly WT levels were achieved by Imig. Anti-GCase IgG was detected in GCase treated mice at 60 U/kg/wk, and IgE mediated acute hypersensitivity and death occurred after several injections of 60 U/kg/wk (21% with Vela and 34% with Imig. The responses of GC levels and storage cell numbers in Vela- and Imig-treated Gaucher mice at various doses provide a backdrop for clinical applications and decisions.

  1. CHANGES IN TUMOR NECROSIS FACTOR ALFA DURING TREATMENT OF PATIENTS WITH MULTIPLE SCLEROSIS BY TRANSIMMUNIZATION METHOD

    Directory of Open Access Journals (Sweden)

    A. V. Kil'dyushevskiy

    2016-01-01

    Full Text Available Background: Despite the availability of a  large number of treatments for multiple sclerosis with various targets, these treatments are not always effective. According to the literature, experimental studies have shown a  significant decrease in tumor necrosis factor alfa (TNF-α with the use of extracorporeal photochemotherapy. Aim: To assess changes in TNF-α in patients with multiple sclerosis during treatment with transimmunization. Materials and methods: The study recruited 13 adult patients with multiple sclerosis. Serum TNF-α was measured by immunochemiluminescence analysis (IMMULITE 1000, Siemens. The patients were treated by transimmunization, i.e. a  modified photopheresis. Two hours before the procedure, Ammifurin (8-methoxypsoralene was administered to all the patients, then their mononuclear cells were isolated under PBSC protocol with Haemonetics MCS+ cell separator. Thereafter, mononuclear cells were irradiated with ultraviolet for 90  minutes and incubated for 20 hours at 37 °С. The next day the cells were re-infused to the patients. The procedure was performed 2  times per week for 6  months, then once per 4  months. Results: Before transimmunization, mean TNF-α level in adult patients with multiple sclerosis was 9.958±0.812  pg/mL (normal, below 8.1 pg/mL. After transimmunization, its level was 6.992±0.367  pg/mL (р<0.05. Conclusion: Ultraviolet irradiation of peripheral blood monocytes with their subsequent incubation (transimmunization led to a 30% decrease of serum TNF-α in patients with multiple sclerosis. This indicates a suppressive effect of transimmunization on TNF-α. Hence, in patients with multiple sclerosis transimmunization exerts an anti-inflammatory effect.

  2. Effects of alfa-hydroxy-isocaproic acid on body composition, DOMS and performance in athletes

    Directory of Open Access Journals (Sweden)

    Karila Tuomo AM

    2010-01-01

    Full Text Available Abstract Background Alfa-Hydroxy-isocaproic acid (HICA is an end product of leucine metabolism in human tissues such as muscle and connective tissue. According to the clinical and experimental studies, HICA can be considered as an anti-catabolic substance. The present study investigated the effects of HICA supplementation on body composition, delayed onset of muscle soreness (DOMS and physical performance of athletes during a training period. Methods Fifteen healthy male soccer players (age 22.1+/-3.9 yr volunteered for the 4-week double-blind study during an intensive training period. The subjects in the group HICA (n = 8 received 583 mg of sodium salt of HICA (corresponding 500 mg of HICA mixed with liquid three times a day for 4 weeks, and those in the group PLACEBO (n = 7 received 650 mg of maltodextrin mixed with liquid three times a day for the same period. According to a weekly training schedule, they practiced soccer 3 - 4 times a week, had strength training 1 - 2 times a week, and had one soccer game during the study. The subjects were required to keep diaries on training, nutrition, and symptoms of DOMS. Body composition was evaluated with a dual-energy X-ray absorptiometry (DXA before and after the 4-week period. Muscle strength and running velocity were measured with field tests. Results As compared to placebo, the HICA supplementation increased significantly body weight (p th week of the treatment (p Conclusion Already a 4-week HICA supplementation of 1.5 g a day leads to small increases in muscle mass during an intensive training period in soccer athletes.

  3. Andexanet alfa effectively reverses edoxaban anticoagulation effects and associated bleeding in a rabbit acute hemorrhage model

    Science.gov (United States)

    Lu, Genmin; Pine, Polly; Leeds, Janet M.; DeGuzman, Francis; Pratikhya, Pratikhya; Lin, Joyce; Malinowski, John; Hollenbach, Stanley J.; Curnutte, John T.

    2018-01-01

    Introduction Increasing use of factor Xa (FXa) inhibitors necessitates effective reversal agents to manage bleeding. Andexanet alfa, a novel modified recombinant human FXa, rapidly reverses the anticoagulation effects of direct and indirect FXa inhibitors. Objective To evaluate the ability of andexanet to reverse anticoagulation in vitro and reduce bleeding in rabbits administered edoxaban. Materials and methods In vitro studies characterized the interaction of andexanet with edoxaban and its ability to reverse edoxaban-mediated anti-FXa activity. In a rabbit model of surgically induced, acute hemorrhage, animals received edoxaban vehicle+andexanet vehicle (control), edoxaban (1 mg/kg)+andexanet vehicle, edoxaban+andexanet (75 mg, 5-minute infusion, 20 minutes after edoxaban), or edoxaban vehicle+andexanet prior to injury. Results Andexanet bound edoxaban with high affinity similar to FXa. Andexanet rapidly and dose-dependently reversed the effects of edoxaban on FXa activity and coagulation pharmacodynamic parameters in vitro. In edoxaban-anticoagulated rabbits, andexanet reduced anti-FXa activity by 82% (from 548±87 to 100±41 ng/ml; P<0.0001), mean unbound edoxaban plasma concentration by ~80% (from 100±10 to 21±6 ng/ml; P<0.0001), and blood loss by 80% vs. vehicle (adjusted for control, 2.6 vs. 12.9 g; P = 0.003). The reduction in blood loss correlated with the decrease in anti-FXa activity (r = 0.6993, P<0.0001) and unbound edoxaban (r = 0.5951, P = 0.0035). Conclusion These data demonstrate that andexanet rapidly reversed the anticoagulant effects of edoxaban, suggesting it could be clinically valuable for the management of acute and surgery-related bleeding. Correlation of blood loss with anti-FXa activity supports the use of anti-FXa activity as a biomarker for assessing anticoagulation reversal in clinical trials. PMID:29590221

  4. Intervalos de Confianza para el coeficiente alfa de Cronbach: aportes a la investigación pediátrica

    Directory of Open Access Journals (Sweden)

    Tomás Caycho-Rodríguez

    2017-06-01

    Full Text Available En la actualidad, es cada vez más común encontrar estudios que brinden evidencias de la confiabilidad de las puntuaciones obtenidas, por instrumentos de medida utilizadas en investigaciones en ciencias de la salud. Este es el caso de la valiosa contribución de Aguilar-Navarro et al, quienes adaptaron la Escala de Actitudes hacia la Alimentación Infantil de Iowa (IIFAS en México, reportando la confiabilidad a través del alfa de Cronbach.

  5. Onset of Type 1 Diabetes Mellitus During Pegylated-interferon Alfa and Ribavirin Therapy for Chronic Hepatitis C Virus Infection

    Science.gov (United States)

    Ranganathan, Raghini; Janarthanan, Krishnaveni; Rajasekaran, Senthilkumar

    2012-01-01

    A 16-year-old female was treated with pegylated-interferon (PEG-IFN) alfa (a)-2b and ribavirin combination therapy for chronic hepatitis C virus (HCV) infection. She attained rapid virological response. She presented with diabetic ketoacidosis after 41 weeks of therapy. Anti-glutamic acid decarboxylase antibodies and islet cell antibodies were negative. Her fasting serum C-peptide level was <0.1 ng/mL, and the treatment course was completed. This case underlines the importance of periodic plasma glucose monitoring in patients during and after PEG-IFN and ribavirin therapy. PMID:25755410

  6. Wykorzystanie metod analitycznych do wyznaczania wielowymiarowych alfa-stabilnych rozkładów prawdopodobieństwa

    OpenAIRE

    Łażewski, Marek; Zator, Krzysztof

    2004-01-01

    In this paper we study the relationship between multivariate a-stable probability distributions and their spectral measure. Analytical method based on nonabelian harmonic analysis is used to express the spectral measure using spherical harmonics on the sphere. Alfa-stabilne rozkłady prawdopodobieństwa, będące uogólnieniem rozkładów normalnych, mają ważną cechę, nie posiadają skończonej wariancji, która utrudnia stosowanie klasycznego formalizmu matematyczno-statystycznego do wyznac...

  7. Is dibotermin alfa a cost-effective substitute for autologous iliac crest bone graft in single level lumbar interbody spine fusion?

    Science.gov (United States)

    Svedbom, Axel; Paech, Daniel; Leonard, Catherine; Donnell, David; Song, Fujian; Boszcyk, Bronek; Rothenfluh, Dominique A; Lloyd, Andrew; Borgman, Benny

    2015-11-01

    To evaluate the cost-effectiveness of dibotermin alfa compared with autologous iliac crest bone graft (ICBG) for patients undergoing single level lumbar interbody spinal fusion in a UK hospital setting. An individual patient data (IPD) meta-analysis of six randomized controlled clinical trials and two single arm trials compared dibotermin alfa on an absorbable collagen implantation matrix (ACIM) (n = 456) and ICBG (n = 244) on resource use, re-operation rates, and SF-6D (Short form 6-dimension) health utility (total N = 700). Failure-related second surgery, operating time, post-operative hospital stay, and quality-adjusted life years (QALYs) derived from the IPD meta-analysis were included as inputs in an economic evaluation undertaken to assess the cost-effectiveness of dibotermin alfa/ACIM versus ICBG for patients undergoing single level lumbar interbody spinal fusion. A four year time horizon and the United Kingdom (UK) National Health Service (NHS) and Personal Social Services (PSS) perspective was adopted in the base case, with sensitivity analyses performed to gauge parameter uncertainty. In the base case analysis, patients treated using dibotermin alfa/ACIM (12 mg pack) accrued 0.055 incremental QALYs at an incremental cost of £ 737, compared with patients treated with ICBG. This resulted in an incremental cost-effectiveness ratio (ICER) of £ 13,523, indicating that at a willingness-to-pay threshold of £ 20,000, dibotermin alfa/ACIM is a cost-effective intervention relative to ICBG from the NHS and PSS perspective. In a UK hospital setting, dibotermin alfa/ACIM is a cost-effective substitute for ICBG for patients who require lumbar interbody arthrodesis.

  8. Feasibility of corifollitropin alfa/GnRH antagonist protocol combined with GnRH agonist triggering and freeze-all strategy in polycystic ovary syndrome patients

    Directory of Open Access Journals (Sweden)

    Jiann-Loung Hwang

    2018-06-01

    Full Text Available Background/Purpose: The long-acting corifollitropin alfa is comparable to FSH in terms of pregnancy outcomes in normal responders and poor responders. Corifollitropin alfa has never been studied in polycystic ovary syndrome (PCOS patients because of concerns of excessive ovarian stimulation and ovarian hyperstimulation syndrome (OHSS. The purpose of the study was to evaluate if corifollitropin alfa can be used in PCOS patients. Methods: Forty PCOS patients who were going to undergo in vitro fertilization were enrolled in this study. A single injection of corifollitropin alfa was administered on cycle day 2 or day 3. From stimulation day 8 onwards, daily FSH was administered until the day of final oocyte maturation. Cetrorelix was administered from stimulation day 5 to prevent premature LH surge. Final oocyte maturation was triggered by: acetate. All embryos were cryopreserved and replaced in subsequent cycles. Results: All 40 patients were subjected to oocyte retrieval, and none developed moderate or severe ovarian hyperstimulation syndrome (0%, 95% CI 0–0.088. For each patient, an average of 23.4 (±7.4; 95% CI 21.0–25.7 oocytes were retrieved and a mean of 11.7 (±6.4; 95% CI 9.6–13.8 embryos were frozen. Mean serum estradiol level on the day of GnRHa triggering was 7829.9 pg/ml (±3297; 95% CI 6775–8885. The cumulated ongoing pregnancy rate after 3 frozen-thawed embryo transfers was 75.0% (95% CI 61.6%–88.4%. Conclusion: The results suggest that corifollitropin alfa/GnRH antagonist protocol can be used in PCOS patients, in combination with GnRHa triggering and embryo cryopreservation. Keywords: Corifollitropin alfa, Cryopreservation, GnRH agonist, Polycystic ovary syndrome

  9. Evaluation of pharmacokinetics, user handling, and tolerability of peginterferon alfa-2a (40 kDa) delivered via a disposable autoinjector device

    Science.gov (United States)

    Varunok, Peter; Lawitz, Eric; Beavers, Kimberly L; Matusow, Gary; Leong, Ruby; Lambert, Nathalie; Bernaards, Coen; Solsky, Jonathan; Brennan, Barbara J; Wat, Cynthia; Bertasso, Anne

    2011-01-01

    Background Peginterferon alfa-2a (40 kDa) is currently administered using a prefilled syringe. The peginterferon alfa-2a disposable autoinjector is a new safety-engineered device designed to facilitate injection and reduce the risk of needlestick injuries. The analysis of two open-label Phase I trials evaluated the pharmacokinetics, successful administration, and tolerability of peginterferon alfa-2a when using the autoinjector. The studies were performed to support the filing and registration of the autoinjector device. Methods In trial 1, 50 healthy adult subjects received one 180 μg dose of peginterferon alfa-2a via the autoinjector. Serial blood samples were collected predose, up to 336 hours following drug administration, and at follow-up (28 ± 3 days post-dosing) for noncompartmental pharmacokinetic analysis. Trial 2 randomized 60 adult patients with chronic hepatitis C to 180 μg peginterferon alfa-2a once weekly by the autoinjector or prefilled syringe for 3 weeks followed by the alternative device (prefilled syringe or autoinjector, respectively) for 3 weeks. Patients also received ribavirin. Administration by the devices was evaluated under direct observation by a study staff member and by patient subjective assessment. Results In trial 1, following a single dose of peginterferon alfa-2a, the maximum plasma concentration was 16.1 ± 5.3 ng/mL (mean ± standard deviation), and area under the concentration time curve (0–168 hours) was 1996 ± 613 ng · hour/mL, similar to that reported using a vial/syringe or prefilled syringe. In trial 2, few patients showed handling difficulties with either device. Generally, patients were observed to be more satisfied and confident, followed instructions better, and successfully initiated injection with the autoinjector versus the prefilled syringe. Patients reported the autoinjector to be more convenient and easier to use. No pain or discomfort was experienced using the autoinjector. The autoinjector safety profile

  10. The influence of a polymorphism in the gene encoding angiotensin converting enzyme (ACE on treatment outcomes in late-onset Pompe patients receiving alglucosidase alfa

    Directory of Open Access Journals (Sweden)

    Rena C. Baek

    2016-09-01

    Full Text Available Correlations between angiotensin-converting enzyme (ACE genotype (I/I, I/D, D/D, disease severity at baseline and response to enzyme replacement therapy (ERT were assessed in the Pompe disease Late-Onset Treatment Study (LOTS. No correlations were observed between ACE genotype and disease severity at baseline. However, D/D patients appeared to have a reduced response to alglucosidase alfa treatment than I/I or I/D patients, suggesting that ACE polymorphisms may influence the response to alglucosidase alfa treatment and warrants further investigation.

  11. CHEMICAL ABUNDANCE PATTERNS IN THE INNER GALAXY: THE SCUTUM RED SUPERGIANT CLUSTERS

    International Nuclear Information System (INIS)

    Davies, Ben; Origlia, Livia; Kudritzki, Rolf-Peter; Figer, Don F.; Rich, R. Michael; Najarro, Francisco; Negueruela, Ignacio; Clark, J. Simon

    2009-01-01

    The location of the Scutum Red Supergiant (RSG) clusters at the end of the Galactic Bar makes them an excellent probe of the Galaxy's secular evolution, while the clusters themselves are ideal testbeds in which to study the predictions of stellar evolutionary theory. To this end, we present a study of the RSG's surface abundances using a combination of high-resolution Keck/NIRSPEC H-band spectroscopy and spectral synthesis analysis. We provide abundance measurements for elements C, O, Si, Mg, Ti, and Fe. We find that the surface abundances of the stars studied are consistent with CNO burning and deep, rotationally enhanced mixing. The average α/Fe ratios of the clusters are solar, consistent with a thin-disk population. However, we find significantly subsolar Fe/H ratios for each cluster, a result which strongly contradicts a simple extrapolation of the Galactic metallicity gradient to lower Galactocentric distances. We suggest that a simple one-dimensional parameterization of the Galaxy's abundance patterns is insufficient at low Galactocentric distances, as large azimuthal variations may be present. Indeed, we show that the abundances of O, Si, and Mg are consistent with independent measurements of objects in similar locations in the Galaxy. In combining our results with other data in the literature, we present evidence for large-scale (∼ kpc) azimuthal variations in abundances at Galactocentric distances of 3-5 kpc. While we cannot rule out that this observed behavior is due to systematic offsets between different measurement techniques, we do find evidence for similar behavior in a study of the barred spiral galaxy NGC 4736 which uses homogeneous methodology. We suggest that these azimuthal abundance variations could result from the intense but patchy star formation driven by the potential of the central bar.

  12. ATLASGAL-selected massive clumps in the inner Galaxy. V. Temperature structure and evolution

    Science.gov (United States)

    Giannetti, A.; Leurini, S.; Wyrowski, F.; Urquhart, J.; Csengeri, T.; Menten, K. M.; König, C.; Güsten, R.

    2017-07-01

    Context. Observational identification of a solid evolutionary sequence for high-mass star-forming regions is still missing. Spectroscopic observations give the opportunity to test possible schemes and connect the phases identified to physical processes. Aims: We aim to use the progressive heating of the gas caused by the feedback of high-mass young stellar objects to prove the statistical validity of the most common schemes used to observationally define an evolutionary sequence for high-mass clumps, and characterise the sensitivity of different tracers to this process. Methods: From the spectroscopic follow-ups carried out towards submillimeter continuum (dust) emission-selected massive clumps (the ATLASGAL TOP100 sample) with the IRAM 30 m, Mopra, and APEX telescopes between 84 GHz and 365 GHz, we selected several multiplets of CH3CN, CH3CCH, and CH3OH emission lines to derive and compare the physical properties of the gas in the clumps along the evolutionary sequence, fitting simultaneously the large number of lines that these molecules have in the observed band. Our findings are compared with results obtained from optically thin CO isotopologues, dust, and ammonia from previous studies on the same sample. Results: The chemical properties of each species have a major role on the measured physical properties. Low temperatures are traced by ammonia, methanol, and CO (in the early phases), the warm and dense envelope can be probed with CH3CN, CH3CCH, and, in evolved sources where CO is abundant in the gas phase, via its optically thin isotopologues. CH3OH and CH3CN are also abundant in the hot cores, and we suggest that their high-excitation transitions are good tools to study the kinematics in the hot gas associated with the inner envelope surrounding the young stellar objects that these clumps are hosting. All tracers show, to different degrees according to their properties, progressive warming with evolution. The relation between gas temperature and the luminosity-to-mass (L/M) ratio is reproduced by a simple toy model of a spherical, internally heated clump. Conclusions: The evolutionary sequence defined for the clumps is statistically valid and we could identify the physical processes dominating in different intervals of L/M. For L/M ≾ 2 L⊙M⊙-1 a large quantity of the gas is still accumulated and compressed at the bottom of the potential well. Between 2 L⊙M⊙-1 ≾ L/M ≾ 40 L⊙M⊙-1 the young stellar objects gain mass and increase in luminosity; the first hot cores hosting intermediate- or high-mass ZAMS stars appear around L/M 10 L⊙M⊙-1. Finally, for L/M ≳ 40 L⊙M⊙-1 Hii regions become common, showing that dissipation of the parental clump dominates. Tables from A.1 to A.8 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/603/A33

  13. VizieR Online Data Catalog: Observed red supergiants in the inner Galaxy (Messineo+, 2016)

    Science.gov (United States)

    Messineo, M.; Zhu, Q.; Menten, K. M.; Ivanov, V. D.; Figer, D. F.; Kudritzki, R.-P.; Rosie, Chen C.-H.

    2018-02-01

    Spectroscopic observations were carried out with the Son of ISAAC (SofI; Moorwood et al. 1998Msngr..91....9M) Spectrograph on the ESO/New Technology Telescope (NTT) 3.58 m telescope of the La Silla Observatory, on the three nights from UT 2015 June 16 to 19-program ID 095.D-0252(A). Spectra with the low-resolution red grism, and the 0.6" wide slit, delivering resolution R~980 over the wavelength range λ=1.53-2.52 μm were obtained for 94 targets. For each target a minimum number of four exposures, nodded along the slit, were taken in an ABBA sequence. Typical integration times per frame ranged from 2 to 100 s (DITsxNDITs). (1 data file).

  14. Tracing major structures of the inner Galaxy with 6.7-GHz methanol masers

    Directory of Open Access Journals (Sweden)

    Pestalozzi M.

    2012-02-01

    Full Text Available Through analysis of correlations within the longitude-velocity distribution of 6.7-GHz methanol masers, we identify density enhancements indicative of large-scale regions of enhanced star formation. In the context of the inner structure of our Galaxy these are interpreted as the starting points of the spiral arms and the interaction of the long Galactic bar with the 3–kpc arms. Signatures of a continuous 3–kpc arm structure are seen including a prominent tangent at –22° Galactic longitude.

  15. Pegylated interferons Lambda-1a and alfa-2a display different gene induction and cytokine and chemokine release profiles in whole blood, human hepatocytes and peripheral blood mononuclear cells.

    Science.gov (United States)

    Freeman, J; Baglino, S; Friborg, J; Kraft, Z; Gray, T; Hill, M; McPhee, F; Hillson, J; Lopez-Talavera, J C; Wind-Rotolo, M

    2014-06-01

    Pegylated interferon-lambda-1a (Lambda), a type III interferon (IFN) in clinical development for the treatment of chronic HCV infection, has shown comparable efficacy and an improved safety profile to a regimen based on pegylated IFN alfa-2a (alfa). To establish a mechanistic context for this improved profile, we investigated the ex vivo effects of Lambda and alfa on cytokine and chemokine release, and on expression of IFN-stimulated genes (ISGs) in primary human hepatocytes and peripheral blood mononuclear cells (PBMCs) from healthy subjects. Our findings were further compared with changes observed in blood analysed from HCV-infected patients treated with Lambda or alfa in clinical studies. mRNA transcript and protein expression of the IFN-λ-limiting receptor subunit was lower compared with IFN-α receptor subunits in all cell types. Upon stimulation, alfa and Lambda induced ISG expression in hepatocytes and PBMCs, although in PBMCs Lambda-induced ISG expression was modest. Furthermore, alfa and Lambda induced release of cytokines and chemokines from hepatocytes and PBMCs, although differences in their kinetics of induction were observed. In HCV-infected patients, alfa treatment induced ISG expression in whole blood after single and repeat dosing. Lambda treatment induced modest ISG expression after single dosing and showed no induction after repeat dosing. Alfa and Lambda treatment increased IP-10, iTAC, IL-6, MCP-1 and MIP-1β levels in serum, with alfa inducing higher levels of all mediators compared with Lambda. Overall, ex vivo and in vivo induction profiles reported in this analysis strongly correlate with clinical observations of fewer related adverse events for Lambda vs those typically associated with alfa. © 2014 John Wiley & Sons Ltd.

  16. SPECIFIC DISORDERS OF THE RESPIRATORY SYSTEM IN CYSTIC FIBROSIS. CLINICAL EFFICACY OF THERAPY WITH DORNASE ALFA IN CHILDREN

    Directory of Open Access Journals (Sweden)

    T.V. Simanova

    2010-01-01

    Full Text Available The article is devoted to specific disorders of the respiratory system in cystic fibrosis. 64 patients with cystic fibrosis (CF aged 2 months to 32 years and residing in the Udmurtian Republic were studied. Epidemiological and genetic specifics of this disease in the mentioned region of the RF were examined. Clinical, X-ray, functional and microbiological studies of the CF patients’ respiratory system were conducted. It was found that genotype delF508 and chronic infection Pseudomonas aeruginosa, Staphylococcus aureus cause severe structural changes to the bronchopulmonary system more often. The obtained data suggest the advisability of identifying the groups of CF patients at the highest risk of severe respiratory system disorders in order to optimise therapeutic efforts. The article provides indicators of clinical efficacy of a dornase alfa therapy in CF children.Key words: cystic fibrosis, genotype, delF508 mutation, respiratory organs, pseudomonas aeruginosa infection, staphylococcal infection, respiratory function, mucolytic function, dornase alfa. (Pediatric Pharmacology. – 2010; 7(6:44-48

  17. Estimadores de consistencia interna en las investigaciones en salud: el uso del coeficiente alfa

    Directory of Open Access Journals (Sweden)

    Franciele Cascaes da Silva

    Full Text Available La producción académica ha aumentado en el área de la salud, exigiendo cada vez más calidad en las publicaciones de gran impacto. Una de las formas de considerar la calidad es por medio de procedimientos que aumentan la consistencia del análisis de los datos, como la confiabilidad, que dependiendo del tipo de datos, puede ser evaluada por diferentes coeficientes, en especial el coeficiente alfa. Basados en lo anterior, la presente revisión reúne sistemáticamente artículos científicos producidos en los últimos cinco años, que de manera metodológica hicieron uso psicométrico del coeficiente α como un estimador de consistencia interna y de confiabilidad en procesos de construcción, adaptación y validación de instrumentos. La identificación de los estudios fue realizada sistemáticamente en las bases de datos Biomed Central Journals, Google Scholar, Web of Science, Wiley Online Library, Medline via Pubmed, Scielo, Scopus, Journals@Ovid, BMJ y Springer por medio del Portal de Periódicos CAPES, utilizando criterios de inclusión y exclusión. El análisis de los datos fue realizado por medio de triangulación, análisis de contenido y análisis descriptivo. Se obtuvo que la mayoría de los estudios fueron realizados principalmente en Irán (f=3, España (f=2 y Brasil (f=2, estos estudios tuvieron como objetivo testar las propiedades psicométricas de instrumentos, siendo que ocho estudios utilizaron el coeficiente α para evaluar la confiabilidad y nueve para evaluar la consistencia interna. Todos los estudios fueron clasificados como investigaciones metodológicas al analizar sus objetivos. Adicionalmente, cuatro estudios también fueron clasificados como correlacionales y uno como descriptivo-correlacional. Se puede concluir que a pesar de que el coeficiente α es ampliamente utilizado como uno de los principales parámetros para la evaluación de consistencia interna de instrumentos de medición del tipo cuestionario en el

  18. Factor de necrosis tumoral alfa en una población infanto-juvenil con sobrepeso

    Directory of Open Access Journals (Sweden)

    Teresita del R. Carrizo

    2013-08-01

    Full Text Available El sobrepeso infantil está asociado a sobrepeso/obesidad en la edad adulta. El tejido adiposo en obesos produce una cantidad incrementada de citoquinas proinflamatorias como el factor de necrosis tumoral alfa (TNF-a, ejerciendo un efecto deletéreo sobre la función vascular. El objetivo de este trabajo fue evaluar niveles de TNF-a en una población infantojuvenil con sobrepeso y su relación con otras variables. Se estudiaron 30 niños con sobrepeso (12 varones de edades entre 8-13 años, se midió circunferencia de cintura (CC e índice de masa corporal (IMC y fueron comparados con 20 controles de edad y sexo semejantes. Se consideró criterio de inclusión un IMC = 85 < 95 percentilo para edad y sexo. En ambos grupos se determinó: glucemia en ayunas (método glucosa oxidasa, insulina plasmática (ECLIA, fibrinógeno (Fg, método de Clauss, proteína C reactiva ultrasensible (uPCR, método inmunoturbidimétrico, TNF-a (ELISA, perfil lipídico (métodos enzimáticos, eritrosedimentación y se calculó el índice HOMA. Los datos se expresaron como mediana y rango intercuartil y con el coeficiente de Spearman se investigaron las correlaciones entre variables, considerándose significativo un p < 0.05. Los niveles de TNF-a fueron mayores en los sujetos con sobrepeso [15.4 (13.2-24.0 vs. 12.7 (11.2-14.8 pg/ml; p = 0.028]. También resultaron más elevados los valores de Fg, insulina plasmática, índice HOMA, uPCR y triglicéridos. El TNF-a se correlacionó con la CC (r = 0.654; p = 0.021. Los niveles elevados de TNF-a, uPCR y Fg encontrados confirman un estado proinflamatorio asociado a obesidad abdominal en la población estudiada.

  19. Arecibo pulsar survey using ALFA. III. Precursor survey and population synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Swiggum, J. K.; Lorimer, D. R.; McLaughlin, M. A.; Bates, S. D.; Senty, T. R. [Department of Physics and Astronomy, West Virginia University, Morgantown, WV 26506 (United States); Champion, D. J.; Lazarus, P. [Max-Planck-Institut für Radioastronomie, D-53121 Bonn (Germany); Ransom, S. M. [NRAO, Charlottesville, VA 22903 (United States); Brazier, A.; Chatterjee, S.; Cordes, J. M. [Astronomy Department, Cornell University, Ithaca, NY 14853 (United States); Hessels, J. W. T. [ASTRON, Netherlands Institute for Radio Astronomy, Postbus 2, 7990 AA, Dwingeloo (Netherlands); Nice, D. J. [Department of Physics, Lafayette College, Easton, PA 18042 (United States); Ellis, J.; Allen, B. [Physics Department, University of Wisconsin-Milwaukee, Milwaukee WI 53211 (United States); Bhat, N. D. R. [Center for Astrophysics and Supercomputing, Swinburne University, Hawthorn, Victoria 3122 (Australia); Bogdanov, S.; Camilo, F. [Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027 (United States); Crawford, F. [Department of Physics and Astronomy, Franklin and Marshall College, Lancaster, PA 17604-3003 (United States); Deneva, J. S. [Arecibo Observatory, HC3 Box 53995, Arecibo, PR 00612 (United States); and others

    2014-06-01

    The Pulsar Arecibo L-band Feed Array (PALFA) Survey uses the ALFA 7-beam receiver to search both inner and outer Galactic sectors visible from Arecibo (32° ≲ ℓ ≲ 77° and 168° ≲ ℓ ≲ 214°) close to the Galactic plane (|b| ≲ 5°) for pulsars. The PALFA survey is sensitive to sources fainter and more distant than have previously been seen because of Arecibo's unrivaled sensitivity. In this paper we detail a precursor survey of this region with PALFA, which observed a subset of the full region (slightly more restrictive in ℓ and |b| ≲ 1°) and detected 45 pulsars. Detections included 1 known millisecond pulsar and 11 previously unknown, long-period pulsars. In the surveyed part of the sky that overlaps with the Parkes Multibeam Pulsar Survey (36° ≲ ℓ ≲ 50°), PALFA is probing deeper than the Parkes survey, with four discoveries in this region. For both Galactic millisecond and normal pulsar populations, we compare the survey's detections with simulations to model these populations and, in particular, to estimate the number of observable pulsars in the Galaxy. We place 95% confidence intervals of 82,000 to 143,000 on the number of detectable normal pulsars and 9000 to 100,000 on the number of detectable millisecond pulsars in the Galactic disk. These are consistent with previous estimates. Given the most likely population size in each case (107,000 and 15,000 for normal and millisecond pulsars, respectively), we extend survey detection simulations to predict that, when complete, the full PALFA survey should have detected 1000{sub −230}{sup +330} normal pulsars and 30{sub −20}{sup +200} millisecond pulsars. Identical estimation techniques predict that 490{sub −115}{sup +160} normal pulsars and 12{sub −5}{sup +70} millisecond pulsars would be detected by the beginning of 2014; at the time, the PALFA survey had detected 283 normal pulsars and 31 millisecond pulsars, respectively. We attribute the deficiency in normal pulsar

  20. Prospective exploratory muscle biopsy, imaging, and functional assessment in patients with late-onset Pompe disease treated with alglucosidase alfa: The EMBASSY Study

    NARCIS (Netherlands)

    A.T. van der Ploeg (Ans); Carlier, P.G. (Pierre G.); Carlier, R.-Y. (Robert-Yves); Kissel, J.T. (John T.); B. Schoser; Wenninger, S. (Stephan); Pestronk, A. (Alan); Barohn, R.J. (Richard J.); Dimachkie, M.M. (Mazen M.); Goker-Alpan, O. (Ozlem); Mozaffar, T. (Tahseen); Pena, L.D.M. (Loren D.M.); Simmons, Z. (Zachary); V. Straub; Guglieri, M. (Michela); Young, P. (Peter); Boentert, M. (Matthias); Baudin, P.-Y. (Pierre-Yves); S.C.A. Wens (Stephan); Shafi, R. (Raheel); Bjartmar, C. (Carl); B. Thurberg

    2016-01-01

    textabstractBackground Late-onset Pompe disease is characterized by progressive skeletal myopathy followed by respiratory muscle weakness, typically leading to loss of ambulation and respiratory failure. In this population, enzyme replacement therapy (ERT) with alglucosidase alfa has been shown to

  1. Elosulfase alfa enzyme replacement therapy attenuates disease progression in a non-ambulatory Japanese patient with Morquio A syndrome (case report

    Directory of Open Access Journals (Sweden)

    Misako Hiramatsu

    2017-12-01

    Full Text Available Enzyme replacement therapy (ERT with elosulfase alfa is the only approved therapy in Japan for patients with Morquio A syndrome, a lysosomal storage disorder inherited in an autosomal recessive fashion. The experience with ERT in severely affected, non-ambulatory patients has not been reported in previous studies. This case report describes clinical evidence for the 1-year efficacy and safety of ERT with elosulfase alfa in a severely affected, non-ambulatory, 47-year-old patient with Morquio A syndrome who needs intensive respiratory management. ERT with elosulfase alfa was well tolerated in this patient. Because of the possibility of potential hypersensitivity adverse events, special attention is needed when using ERT in patients with respiratory disorders. However, under the appropriate management of specialists, the patient in this case report showed significant respiratory improvement after starting ERT, and abdominal bloating was improved by gas evacuation. In addition, the patient was able to lift up her arms, reach behind her back, and move her legs slightly, and she recovered her grip strength. Her hearing loss improved and she could hear without a hearing aid. This report shows that ERT with elosulfase alfa can be used with appropriate respiratory care in patients with severe respiratory dysfunction.

  2. Epoetin alfa improves anemia and anemia-related, patient-reported outcomes in patients with breast cancer receiving myelotoxic chemotherapy: Results of a european, multicenter, randomized, controlled trial

    NARCIS (Netherlands)

    P. Pronzato (Paolo); E. Cortesi (Enrico); C.C.D. van der Rijt (Carin); A. Bols (Alain); J.A. Moreno-Nogueira (José); C.F. de Oliveira; P. Barrett-Lee (Peter); P.J. Ostler (Peter); R. Rosso (Ricardo)

    2010-01-01

    textabstractPurpose. To evaluate the effects of epoetin alfa on patient- reported outcomes (PROs) in patients with breast cancer receiving myelotoxic chemotherapy. Materials and Methods. Women with hemoglobin concentrations ≤12.0 g/dl and an Eastern Cooperative Oncology Group performance status

  3. Effectiveness of interferon alfa on incidence of hepatocellular carcinoma and decompensation in cirrhosis type C. European Concerted Action on Viral Hepatitis (EUROHEP)

    DEFF Research Database (Denmark)

    Fattovich, G; Giustina, G; Degos, F

    1997-01-01

    The role of interferon alfa treatment in improving morbidity endpoints in patients with chronic hepatitis C infection is currently under debate. The aim of this study was to evaluate the effectiveness of interferon in preventing hepatocellular carcinoma and decompensation in cirrhosis type C....

  4. An open-label clinical trial to investigate the efficacy and safety of corifollitropin alfa combined with hCG in adult men with hypogonadotropic hypogonadism.

    Science.gov (United States)

    Nieschlag, Eberhard; Bouloux, Pierre-Marc G; Stegmann, Barbara J; Shankar, R Ravi; Guan, Yanfen; Tzontcheva, Anjela; McCrary Sisk, Christine; Behre, Hermann M

    2017-03-07

    Hypogonadotropic hypogonadism (HH) in men results in insufficient testicular function and deficiencies in testosterone and spermatogenesis. Combinations of human chorionic gonadotropin (hCG) and recombinant follicle-stimulating hormone (recFSH) have been successful in the treatment of HH. Corifollitropin alfa is a long-acting FSH-analog with demonstrated action in women seeking infertility care. The aim of this study was to investigate the efficacy and safety of corifollitropin alfa combined with hCG to increase testicular volume and induce spermatogenesis in men with HH. This was a Phase III, multi-center, open-label, single-arm trial of corifollitropin alfa in azoospermic men aged 18 to 50 years with HH. After 16 weeks of pretreatment of 23 subjects with hCG alone, 18 subjects with normalized testosterone (T) levels who remained azoospermic entered the 52-week combined treatment phase with hCG twice-weekly and 150 μg corifollitropin alfa every other week. The increase in testicular volume (primary efficacy endpoint) and induction of spermatogenesis resulting in a sperm count ≥1 × 10 6 /mL (key secondary efficacy endpoint) during 52 weeks of combined treatment were assessed. Safety was evaluated by the presence of anti-corifollitropin alfa antibodies and the occurrence of adverse events (AEs). Mean (±SD) testicular volume increased from 8.6 (±6.09) mL to 17.8 (±8.93) mL (geometric mean fold increase, 2.30 [95% CI: 2.03, 2.62]); 14 (77.8%) subjects reached a sperm count ≥1 × 10 6 /mL. No subject developed confirmed anti-corifollitropin alfa antibodies during the trial. Treatment was generally well tolerated. Corifollitropin alfa 150 μg administrated every other week combined with twice-weekly hCG for 52 weeks increased testicular volume significantly, and induced spermatogenesis in >75% of men with HH who had remained azoospermic after hCG treatment alone. ClinicalTrials.gov: NCT01709331 .

  5. Oral sucrosomial iron versus intravenous iron in anemic cancer patients without iron deficiency receiving darbepoetin alfa: a pilot study.

    Science.gov (United States)

    Mafodda, Antonino; Giuffrida, D; Prestifilippo, A; Azzarello, D; Giannicola, R; Mare, M; Maisano, R

    2017-09-01

    Erythropoiesis-stimulating agents (ESAs) are often used in treatment of patients with chemotherapy-induced anemia. Many studies have demonstrated an improved hemoglobin (Hb) response when ESA is combined with intravenous iron supplementation and a higher effectiveness of intravenous iron over traditional oral iron formulations. A new formulation of oral sucrosomial iron featuring an increased bioavailability compared to traditional oral formulations has recently become available and could provide a valid alternative to those by intravenous (IV) route. Our study evaluated the performance of sucrosomial iron versus intravenous iron in increasing hemoglobin in anemic cancer patients receiving chemotherapy and darbepoetin alfa, as well as safety, need of transfusion, and quality of life (QoL). The present study considered a cohort of 64 patients with chemotherapy-related anemia (Hb >8 g/dL iron deficiency, scheduled to receive chemotherapy and darbepoetin. All patients received darbepoetin alfa 500 mcg once every 3 weeks and were randomly assigned to receive 8 weeks of IV ferric gluconate 125 mg weekly or oral sucrosomial iron 30 mg daily. The primary endpoint was to demonstrate the performance of oral sucrosomial iron in improving Hb response, compared to intravenous iron. The Hb response was defined as the Hb increase ≥2 g/dL from baseline or the attainment Hb ≥ 12 g/dL. There was no difference in the Hb response rate between the two treatment arms. Seventy one percent of patients treated with IV iron achieved an erythropoietic response, compared to 70% of patients treated with oral iron. By conventional criteria, this difference is considered to be not statistically significant. There were also no differences in the proportion of patients requiring red blood cell transfusions and changes in QoL. Sucrosomial oral iron was better tolerated. In cancer patients with chemotherapy-related anemia receiving darbepoetin alfa, sucrosomial oral iron provides

  6. Diversidad alfa y beta de la comunidad de reptiles en el complejo cenagoso de Zapatosa, Colombia

    Directory of Open Access Journals (Sweden)

    Guido Fabián Medina-Rangel

    2011-06-01

    Full Text Available La diversidad es una propiedad de las comunidades, permite describir, caracterizar y entender el funcionamiento de los ecosistemas. Para estudiar la riqueza, abundancia y el recambio de especies de reptiles entre hábitats circundantes al complejo cenagoso de Zapatosa, se realizaron cuatro salidas de campo (noviembre de 2006 y octubre de 2007. Se invirtieron 640h/hombre de muestreo repartido en cinco tipos de hábitat: bosque casmófito, bosque seco, bosque de ribera, palmar y sabana arbolada. Se encontraron 847 individuos de 48 especies, la familia más rica fue Colubridae, se registraron cinco especies endémicas y ocho con algún grado de amenaza en conservación a nivel nacional. El hábitat más diverso fue el bosque de ribera. La representatividad del muestreo en total y para cada hábitat fue superior al 80%, con excepción del palmar (Alfa and beta diversity of reptilian assemblages in Zapatosa wetland complex, Colombia. Diversity is a property of community that can described, characterized, and understood according to the functioning of ecosystems. To study the richness and local abundance and species replacement between habitats around the Zapatosa’s wetland complex (El Cesar Department, I carried out four field trips between November of 2006 and October of 2007. A total of 640 sampling hours/man analyzed five habitat types chasmophyte forest, dry forest, riparian forest, palm-grove and tree-lined savanna; with the exception of the palm-grove sampled at its 75%, the others were sampled up to their 80%. I found 847 reptiles that were distributed in 48 species. The group with the highest number of species was Colubridae with 14, followed by Gekkonidae with five. Five endemic species and eight with some conservation threat grade at a national level a re reported. The riparian forest was the richest and most abundant habitat with 34 species and 196 individuals. For each habitat, Colubridae had the highest number of species, followed by

  7. Deficiência de alfa-1 antitripsina: diagnóstico e tratamento Alpha-1 antitrypsin deficiency: diagnosis and treatment

    Directory of Open Access Journals (Sweden)

    Aquiles A Camelier

    2008-07-01

    Full Text Available A deficiência de alfa-1 antitripsina é um distúrbio genético de descoberta recente e que ocorre com freqüência comparável à da fibrose cística. Resulta de diferentes mutações no gene SERPINA1 e tem diversas implicações clínicas. A alfa-1 antitripsina é produzida principalmente no fígado e atua como uma antiprotease. Tem como principal função inativar a elastase neutrofílica, impedindo a ocorrência de dano tecidual. A mutação mais freqüentemente relacionada à doença clínica é o alelo Z, que determina polimerização e acúmulo dentro dos hepatócitos. O acúmulo e a conseqüente redução dos níveis séricos de alfa-1 antitripsina determinam, respectivamente, doença hepática e pulmonar, sendo que esta se manifesta principalmente sob a forma de enfisema de aparecimento precoce, habitualmente com predomínio basal. O diagnóstico envolve a detecção de níveis séricos reduzidos de alfa-1 antitripsina e a confirmação fenotípica. Além do tratamento usual para doença pulmonar obstrutiva crônica, existe atualmente uma terapia específica com infusão de concentrados de alfa-1 antitripsina. Essa terapia de reposição, aparentemente segura, ainda não teve a eficácia clínica definitivamente comprovada, e o custo-efetividade também é um tema controverso e ainda pouco abordado. Apesar da sua importância, não existem dados epidemiológicos brasileiros a respeito da prevalência da doença ou da freqüência de ocorrência dos alelos deficientes. O subdiagnóstico também tem sido uma importante limitação tanto para o estudo da doença quanto para o tratamento adequado dos pacientes. Espera-se que a criação do Registro Internacional de Alfa-1 venha a resolver essas e outras importantes questões.Alpha-1 antitrypsin deficiency is a recently identified genetic disease that occurs almost as frequently as cystic fibrosis. It is caused by various mutations in the SERPINA1 gene, and has numerous clinical

  8. Evaluation of pharmacokinetics, user handling, and tolerability of peginterferon alfa-2a (40 kDa delivered via a disposable autoinjector device

    Directory of Open Access Journals (Sweden)

    Varunok P

    2011-11-01

    Full Text Available Peter Varunok1, Eric Lawitz2, Kimberly L Beavers3, Gary Matusow4, Ruby Leong5, Nathalie Lambert6, Coen Bernaards7, Jonathan Solsky5, Barbara J Brennan5, Cynthia Wat8, Anne Bertasso51Gastroenterology Associates, Poughkeepsie, NY, USA; 2Alamo Medical Research, San Antonio, TX, USA; 3Asheville Gastroenterology, Asheville, NC, USA; 4Gastroenterology Group, South Jersey, NJ, USA; 5Roche, Nutley, NJ, USA; 6Roche, Basel, Switzerland; 7Roche, San Francisco, CA, USA; 8Roche, Welwyn, UKBackground: Peginterferon alfa-2a (40 kDa is currently administered using a prefilled syringe. The peginterferon alfa-2a disposable autoinjector is a new safety-engineered device designed to facilitate injection and reduce the risk of needlestick injuries. The analysis of two open-label Phase I trials evaluated the pharmacokinetics, successful administration, and tolerability of peginterferon alfa-2a when using the autoinjector. The studies were performed to support the filing and registration of the autoinjector device.Methods: In trial 1, 50 healthy adult subjects received one 180 µg dose of peginterferon alfa-2a via the autoinjector. Serial blood samples were collected predose, up to 336 hours following drug administration, and at follow-up (28 ± 3 days post-dosing for noncompartmental pharmacokinetic analysis. Trial 2 randomized 60 adult patients with chronic hepatitis C to 180 µg peginterferon alfa-2a once weekly by the autoinjector or prefilled syringe for 3 weeks followed by the alternative device (prefilled syringe or autoinjector, respectively for 3 weeks. Patients also received ribavirin. Administration by the devices was evaluated under direct observation by a study staff member and by patient subjective assessment.Results: In trial 1, following a single dose of peginterferon alfa-2a, the maximum plasma concentration was 16.1 ± 5.3 ng/mL (mean ± standard deviation, and area under the concentration time curve (0–168 hours was 1996 ± 613 ng · hour

  9. DAHANCA 10 – Effect of darbepoetin alfa and radiotherapy in the treatment of squamous cell carcinoma of the head and neck. A multicenter, open-label, randomized, phase 3 trial by the Danish head and neck cancer group

    DEFF Research Database (Denmark)

    Overgaard, Jens; Hoff, Camilla Molich; Hansen, Hanne Sand

    2018-01-01

    Purpose: To evaluate if correction of low hemoglobin (Hb) levels by means of darbepoetin alfa improves the outcomes of radiotherapy in patients with squamous cell carcinoma of the head and neck (HNSCC). Patients and methods: Patients eligible for primary radiotherapy and who had Hb values below 14.......0 g/dl were randomized to receive accelerated fractionated radiotherapy with or without darbepoetin alfa. Patients also received the hypoxic radiosensitizer nimorazole. Darbepoetin alfa was given weekly during radiotherapy or until the Hb value exceeded 15.5 g/dl. Results: Following a planned interim...... distributed according to the stratification parameters (gender, T and N staging, tumor site). Treatment with darbepoetin alfa increased the Hb level to the planned value in 81% of the patients. The compliance was good without excess serious adverse events. The results showed a poorer outcome with a 5-year...

  10. Fungal Alfa Amilaz ve Deaktif Kuru Maya Preparatları Kullanılarak Hızlandırılmış Ekmek Yapımı

    OpenAIRE

    Bilgiçli, Nermin; Türker, Selman; Elgün, Adem

    2015-01-01

    The aim of this research is the determination of optimum fermentation time giving the best bread quality with fungal alfa amylase and a reducing agent-deactive dry yeast preparetes at different flour types in bread making. In the experiment two different enzyme praperates (Fungal Alfa Amylase and Reducing Agent-Deactive dry yeast) were added at three different types of flour (Type 550, 650 and 850) and prepared bread dough. The dough was rested during three different bulk fermentation time (1...

  11. Peginterferon alpha-2a is associated with higher sustained virological response than peginterferon alfa-2b in chronic hepatitis C: systematic review of randomized trials

    DEFF Research Database (Denmark)

    Awad, Tahany; Thorlund, Kristian; Hauser, Goran

    2010-01-01

    ) is most effective. We performed a systematic review of head-to-head randomized trials to assess the benefits and harms of the two treatments. We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and LILACS through July 2009. Using standardized forms, two reviewers independently...... extracted data from each eligible trial report. We statistically combined data using a random effects meta-analysis according to the intention-to-treat principle. We identified 12 randomized clinical trials, including 5,008 patients, that compared peginterferon alpha-2a plus ribavirin versus peginterferon...... alfa-2b plus ribavirin. Overall, peginterferon alpha-2a significantly increased the number of patients who achieved a sustained virological response (SVR) versus peginterferon alfa-2b (47% versus 41%; risk ratio 1.11, 95% confidence interval 1.04-1.19; P = 0.004 [eight trials]). Subgroup analyses...

  12. Diffusion Kurtosis Imaging Detects Microstructural Alterations in Brain of alfa-Synuclein Overexpressing Transgenic Mouse Model of Parkinson’s Disease: A Pilot Study

    Czech Academy of Sciences Publication Activity Database

    Khainar, A.; Latta, P.; Dražanová, Eva; Rudá-Kučerová, J.; Szabó, N.; Arab, A.; Hutter-Paier, B.; Havas, D.; Windisch, M.; Šulcová, A.; Starčuk jr., Zenon; Rektorová, I.

    2015-01-01

    Roč. 28, č. 4 (2015), 281-289 ISSN 1029-8428 R&D Projects: GA MŠk(CZ) LO1212; GA MŠk ED0017/01/01 Institutional support: RVO:68081731 Keywords : diffusion kurtosis imaging * alfa-Synuclein * TNWT-61 * Parkinson’s disease * Transgenic mice * TBSS Subject RIV: BH - Optics, Masers, Lasers Impact factor: 3.140, year: 2015

  13. Corifollitropin alfa compared to daily rFSH or HP-HMG in GnRH antagonist controlled ovarian stimulation protocol for patients undergoing assisted reproduction.

    Science.gov (United States)

    Souza, Priscila Morais Galvão; Carvalho, Bruno Ramalho de; Nakagawa, Hitomi Miura; Rassi, Thalita Reis Esselin; Barbosa, Antônio César Paes; Silva, Adelino Amaral

    2017-06-01

    This study aimed to compare the outcomes of controlled ovarian stimulation (COS) with corifollitropin alfa versus daily recombinant follicle-stimulating hormone (rRFSH) or highly purified human menopausal gonadotropin (HP-HMG) in patients undergoing in vitro fertilization (IVF) cycles based on gonadotropin-releasing hormone (GnRH) antagonist protocols. The primary endpoints were total number of oocytes and mature oocytes. This retrospective study looked into 132 controlled ovarian stimulation cycles from IVF or oocyte cryopreservation performed in a private human reproduction center between January 1 and December 31, 2014. Enrollment criteria: women aged 0.05). There were no significant differences in fertilization (76.9% vs. 76.8%, p=1.0), biochemical pregnancy (66.7% vs. 47.2%, p=0.1561) or embryo implantation rates (68.7% vs. 50%, p=0.2588) between the groups using corifollitropin alfa and rFSH or HMG, respectively. Corifollitropin alfa seems to be as effective as rFSH or HP-HMG when used in the first seven days of ovulation induction for patients undergoing assisted reproduction in GnRH antagonist protocols.

  14. An Open-label, Single-dose, Pharmacokinetic Study of Factor VIII Activity After Administration of Moroctocog Alfa (AF-CC) in Male Chinese Patients With Hemophilia A.

    Science.gov (United States)

    Liu, Hongzhong; Wu, Runhui; Hu, Pei; Sun, Feifei; Xu, Lihong; Liang, Yali; Nepal, Sunil; Qu, Peng Roger; Huard, Francois; Korth-Bradley, Joan M

    2017-07-01

    Hemophilia A represents up to 80% of all hemophilia cases in China. In patients with this condition, bleeding can be prevented and controlled by administering clotting factor VIII (FVIII). Since their initial availability, recombinant FVIII products have undergone several iterations to enhance their safety. Moroctocog alfa albumin-free cell culture (AF-CC) is among the third generation of recombinant FVIII products and received regulatory approval in China in August 2012. The present study characterizes the single-dose pharmacokinetic parameters of FVIII activity (FVIII:C) after administration of moroctocog alfa (AF-CC) in male Chinese patients with hemophilia A. This multicenter, open-label, single-dose study enrolled 13 male Chinese patients diagnosed with severe hemophilia A (FVIII:C hemophilia A. The pharmacokinetic profile in older patients was similar to that previously reported with recombinant FVIII products in studies with a predominantly white population; younger patients had reduced exposure to FVIII:C. The single doses of moroctocog alfa (AF-CC) were well tolerated; 2 cases of transient, low-titer FVIII inhibitor development were observed. ClinicalTrials.gov identifier: NCT02461992. Copyright © 2017 Elsevier HS Journals, Inc. All rights reserved.

  15. Uso tópico do inteferon alfa-2b para neoplasia escamosa da superficie ocular em um caso de paciente com xeroderma pigmentoso

    Directory of Open Access Journals (Sweden)

    Nayara Queiroz Cardoso Pinto

    Full Text Available Resumo Relato de um caso clínico de Xeroderma Pigmentoso com carcinoma espinocelular de conjuntiva bilateral que apresentou regressão importante das dimensões tumorais com o uso de Interferon alfa-2b tópico. Relato de caso: Paciente feminina com Xeroderma Pigmentoso em estágio avançado, com ausência de pele sadia, tendo sido submetida a cerca de 60 exéreses de lesões de pele malignas. A paciente compareceu com tumoração conjuntival em ambos os olhos, correspondendo a carcinoma espinocelular de conjuntiva e neoplasia intraepitelial de conjuntiva em olho esquerdo. Devido as dificuldades cirúrgicas, alta taxa de recidiva e elevada probabilidade de formação de simbléfaro foi-se iniciado terapêutica com Interferon alfa-2beta 1.000.000 unidades tópico, obtendo-se bons resultados com importante regressão do tamanho da lesão e resolução dos sintomas. Conclusão: O uso tópico de interferon alfa-2beta em neoplasia escamosa de conjuntiva, mostrou-se uma boa opção terapêutica em situações de elevado risco cirúrgico e de complicações pós operatórias.

  16. Tratamento de hemangioma gigante com interferon alfa: relato de dois casos Treatment of giant hemangioma with interferon-alpha: report of two cases

    Directory of Open Access Journals (Sweden)

    Ana Julia Balau

    2007-12-01

    Full Text Available O objetivo do trabalho é descrever o uso de interferon alfa no tratamento de pacientes com hemangioma gigante. Os autores relatam e analisam dois casos de hemangioma gigante em tratamento com interferon alfa. IBS, 3 anos, em acompanhamento no Ambulatório de Hematologia desde um ano de idade com quadro de lesão angiomatosa em praticamente toda hemiface direita, acompanhada de sangramentos gengivais importantes. Após a realização de exames complementares (Angiorressonância magnética e feito o diagnóstico de hemangioma gigante em face, foi iniciado tratamento com prednisona e, posteriormente, associação com interferon alfa e observada importante melhora do quadro, resultando na diminuição dos episódios de sangramento e no tamanho do tumor. C.N.P., 12 anos, apresentando nódulo em região lateral de joelho esquerdo há 2 anos, com aumento progressivo do tamanho e dor local. Fez uso de prednisona e, sem melhora do quadro, introduzido interferon alfa com regressão importante do tamanho do tumor. O tratamento com interferon alfa deve ser considerado no tratamento de hemangiomas, pois apresenta bons resultados em relação à diminuição do tamanho do tumor e, conseqüentemente, reduz as intercorrências clínicas associadas à sua presença, principalmente os sangramentos.The aim of this study is to describe the treatment using interferon-alpha of giant hemangiomas in children. The authors report two cases of children presenting with giant hemangiomas treated using interferon-alpha and analyze the results. IBS, 3 years-old, has been followed up in Famema Hemathology Service since she was 1 year-old with a tumor on the face and persistent bleeding. After clinical and radiologic evaluations and suggested the diagnosis of giant hemangioma, she started treatment with interferon-alpha. A great clinical improvement was observed a reducing of the number of episodes of bleedings and a decrease in of the tumor size. CNP, 12 years-old, came to

  17. Efektivitas Penambahan Vitamin E (alfa-Tokoferol dalam Medium Pencucian Sperma dengan Sentrifugasi terhadap Kualitas Spermatozoa Sapi Brahman

    Directory of Open Access Journals (Sweden)

    Dasrul Dasrul

    2012-10-01

    Full Text Available Effect of vitamin E addition (alfa-tokoferol into sperm washing medium by centrifuge on the quality of Brahman cattle spermatozoa  ABSTRACT. The aims of study to determine the effectiveness of the addition of vitamin E in the washing medium by centrifugation on sperm quality Brahman cattle. frozen semen of Brahman cattle, divided into 4 treatment groups addition of vitamin E in the washing medium: 0.0gr/100 ml medium (K0, 0.1gr /100 ml medium (K1; 0.2gr/100 ml medium (K2 and 0.3 g / 100 ml medium (K4, each group was repeated 5 times. Examination of motility, viability and integrity of sperm membrane performed according to WHO standards. The data obtained were analyzed with one-way ANOVA and Duncan test. The average percentage of motility, viability and membrane integrity of spermatozoa in the addition of vitamin E were significantly different (P 0.05 compared with the group K0. The addition of vitamin E in the medium on the process of washing spermatozoa Brahman cattle. The addition of vitamin E 0.2gr/100ml better than vitamin E 0.1gr/100ml and 0.3gr/100ml in maintaining the percentage of motility and live spermatozoa Brahman cattle.

  18. Study of forward elastic $pp$ scattering at $\\sqrt{s}=8\\text{ TeV}$ with the ALFA detector

    CERN Document Server

    Stark, Simon Holm; Hansen, Jørgen Beck

    The elastic $pp$ scattering data analyzed in this thesis was taken at the LHC with the ALFA detector at $\\sqrt{s}=8\\text{ TeV}$ with a $\\beta^*=1\\text{ km}$ collision optics which gave access to the Coulomb-Nuclear-Interference region. An improved procedure was used to fit the observed number of elastic events as a function of the four-momentum transfer with a simulation based on theoretical expectations including experimental effects. The data can not exclude any of the investigated parametrizations for the modulus of the nuclear amplitude. The fit results for the total $pp$ cross section, $\\sigma_\\text{tot}$, and the ratio of the real to imaginary forward elastic scattering amplitude, $\\rho$, are: \\begin{align*} \\sigma_\\text{tot} &= 99.1\\pm 0.3 \\text{ (stat.)}\\pm1.6\\text{ (syst.)} \\text{ mb}\\;,\\\\ \\rho &= 0.166\\pm0.017\\text{ (stat.)}\\pm0.019\\text{ (syst.)}\\;, \\end{align*} which are in agreement with previous measurements. As part of the analysis, the detector distance to the beam was determined with ...

  19. Benefit of adjuvant interferon alfa-2b (IFN-α) therapy in melanoma patients with high serum MMP-8 levels

    DEFF Research Database (Denmark)

    Vihinen, Pia; Tervahartiala, Taina; Sorsa, Timo

    2015-01-01

    Matrix metalloproteinases (MMPs) are important enzymes in tissue turnover and various inflammatory processes. In this study, it was evaluated whether serum MMP-8 can predict the response to adjuvant interferon alfa-2b (IFN-α) therapy in patients with operated high-risk cutaneous melanoma. Pre......-treatment sera from 460 patients with stage IIB-IIIC melanoma were analyzed for MMP-8. The patients were randomized after surgery to adjuvant IFN-α for 12 or 24 months (n = 313) or observation only (n = 147). The median serum MMP-8 level was used to classify the patients into a low MMP-8 (n = 232) and a high MMP......-8 (n = 228) group. In the high MMP-8 subgroup, IFN-α therapy significantly improved relapse-free survival (RFS). RFS was 36.8 months in patients with high MMP-8 levels receiving IFN-α therapy, whereas RFS for those with high MMP-8 levels with observation only was 10.6 months (P = 0.027). Median...

  20. THE INFLUENCE OF ASOCIATED SUPPLEMENT OF ALFA AMYLASE AND XYLANASE ON THE RHEOLOGY OF DOUGH CONCEARNING ITS CONSTITOGRAPHICAL PARAMETERS

    Directory of Open Access Journals (Sweden)

    RODICA CHEREJI

    2009-05-01

    Full Text Available In this paper we determined the influence of associated supplement of alfa amylase and xylanase on the rheology of dough concearning its constitographical parameters : maximum pressure (Pr max, (mb and the absorbed water (Wa, %. The analysis on the consistograph were conducted for constant hydration at the consistency of 500 UF. Determinations were made on 4 types of flour and optimal dosages were found for each enzyme, after which we prepared the optimal dosage of the enzymes in the compund for flour F1 and F2 : P1-840000 U. SKB/100 kg flour +8100 U. FXU /100 kg flour, P2-840000 U. SKB/100 kg flour+16200 U. FXU, /100 kg flour , P3-840000 U. SKB/100 kg flour+24300 U. FXU/100 kg flour , and for F3 and F4 thus: P1-280000 U. SKB/100 kg flour +8100 U. FXU /100 kg flour, P2- 280000 U. SKB/100 kg flour+16200 U. FXU/100 kg flour, P3-280000 U. SKB/100 kg flour+24300 U. FXU/100 kg flour. Fungous α-amylase and xylanase were used in these concentrations to establish which one is more apropriate to be added in flour to obtain superior quality of bread: finer texture of the crumb, prolongation of the freashness of the bread, improvind the colour and flavour, emproving the slicing ability.

  1. Um imunoensaio rápido para a detecção de alfa-trembolona em urina bovina

    Directory of Open Access Journals (Sweden)

    Keila Maria Roncato Duarte

    2006-12-01

    Full Text Available O Brasil está entre os países que mantêm o uso de anabolizantes proibido, o que gera dificuldades muito grandes no monitoramento destas substâncias, uma vez que possui o maior rebanho bovino. Contudo, diversas substâncias são largamente utilizadas, entre as quais o acetato de trembolona. Com o consentimento do Ministério da Agricultura, Pecuária e Abastecimento, foram produzidos anticorpos policlonais para um teste baseado em ELISA ("enzyme linked immunosorbent assay" capazes de detectar acetato de trembolona na urina de bovinos tratados com trembolona. O teste apresentou baixo custo e de fácil execução para a detecção de alfa-trembolone, o principal metabólito na absorção do acetato de trembolona, liberado na urina dos animais. Os resultados foram similares aos obtidos com o "kit" comercial usado pelo Ministério da Agricultura, Pecuária e Abastecimento do Brasil.

  2. Comparison of corifollitropin alfa and daily recombinant follicle-stimulating hormone in poor responder patients undergoing in vitro fertilization cycles

    Directory of Open Access Journals (Sweden)

    Süleyman Akarsu

    2017-12-01

    Full Text Available Objective The aim of this study was to compare the effect of corifollitropin alfa (CFA and recombinant follicle-stimulating hormone (rFSH in poor-responder patients undergoing antagonist cycles. Materials and Methods The study was a retrospective analysis of the treatment results of 214 poor responder patients who had been admitted to the In Vitro Fertilization Unit of İzmir Medical Park Hospital between November 2014 and November 2016. Intracytoplasmic sperm injections were performed in 38 patients (group 1 with CFA, and the remaining 176 (group 2 with rFSH for controlled ovarian hyperstimulation. Results The age, body mass index, anti-müllerian hormone level, duration of infertility, duration of induction and antral follicle number were similar in the two groups. There was no difference in the total aspirated oocyte counts, mature oocyte ratio, fertilization rate, implantation rate, and clinical pregnancy rates between the two groups. The implantation rate was 9/38 (23.6% in group 1 and 42/176 (23.8% in group 2, whereas the clinical pregnancy rates were 16.3% and 17.2%, respectively. Conclusion No difference was found in terms of oocyte count, fertilization rate, implantation rate, and clinical pregnancy rates of CFA or rFSH use in the antagonist cycles in poor-responder patients.

  3. Comparing effects of Beractant and Poractant alfa in decreasing mortality rate due to respiratory distress syndrome in premature infants

    Directory of Open Access Journals (Sweden)

    Saeidi R

    2011-02-01

    Full Text Available "nBackground: Exogenous natural and synthetic surfactants is a rescue treatment for respiratory distress syndrome (RDS. The goals of the study were to compare the clinical response and side-effects of two frequently used surfactants, poractant alfa (Curosurf and beractant (Survanta, for the treatment of respiratory distress syndrome in preterm infants."n "nMethods: This clinical trial study was performed during a two-year period in the Neonatal Intensive Care Unit of Ghaem Hospital in Mashhad, Iran. Sample size calculated by a 95% confidence and power of 80, included 104 premature neonates, 74 in survanta and 30 in curosurf groups. The level of statistical significance was considered to be < 0.05."n "nResults: There were no statistically significant differences between the infants treated by survanta or cursurf groups regarding their mean gestational age (30.58 Vs. 29.00 weeks and birth weight (1388 Vs. 1330 g, (p=0.3 There were also no significant differences between the two groups regarding incidences of broncho- pulmonary dysplasia (BPD (40.5% Vs. 40%, intraventricular hemorrhage (IVH grades III/IV (13.5% Vs. 13.3%, pneumothorax (both 20%, patent ductus arteriosus (PDA (28/3% Vs. 20% or death (28% Vs. 26.6% on the 28th day postpartum."n "nConclusion: This study showed that survanta and curosurf had similar therapeutic effects in the treatment of neonatal respiratory distress syndrome.

  4. Study of forward elastic pp scattering at √ s = 8 TeV with the ALFA detector

    DEFF Research Database (Denmark)

    Stark, Simon Holm

    The elastic proton-proton scattering data analyzed in this thesis was taken at the LHC with the ALFA detector at sqrt(s) = 8 TeV with a beta* collision optics which gave access to the Coulomb-Nuclear-Interference region. An improved procedure was used to fit the observed number of elastic events......_tot, and the ratio of the real to imaginary forward elastic scattering amplitude, rho, are: sigma_tot = 99.1 +/- 0.3 (stat.) +/- 1.6 (syst.) mb rho = 0.166 +/- 0.017 (stat.) +/- 0.019 (syst.) which are in agreement with previous measurements. As part of the analysis, the detector distance to the beam was determined...... with an improved method. A new background estimation procedure was developed and also implemented in the determination of the elastic track reconstruction efficiency. The experience gained in this thesis was used to optimize the experimental settings for a new data taking at sqrt(s) = 13 TeV with beta* = 2.5 km...

  5. Unidades fototérmicas e temperatura-base inferior de frutos de Mangueira Alfa, na Baixada Cuiabana Photothermal units and lower base temperature for alfa mango fruit on the Baixada Cuiabana

    Directory of Open Access Journals (Sweden)

    Marcelo Paes de Barros

    2010-06-01

    Full Text Available O objetivo deste trabalho foi determinar a temperatura-base inferior (Tb a partir da unidade fototérmica (UF para o cultivo experimental de manga Alfa sob condições de cerrado. Foram utilizados dados diários da temperatura do ar disponibilizados pela Estação Agrometeorológica Padre Ricardo Remetter, localizada em Santo Antônio do Leverger-MT (15,8° S e 56,1° W, 140 m, e avaliação sensorial do estádio de maturação dos frutos de manga. A Tb foi determinada pelo método da menor variabilidade das unidades fototérmicas (UF acumuladas do período da floração à colheita dos frutos, variabilidade avaliada pelo coeficiente de variação (cv simulado para diferentes valores da Tb. De julho a novembro de 2007, em três plantas de um pomar demonstrativo irrigado, foram identificados 82 frutos para o acompanhamento do crescimento e maturação. Entre esses frutos, em meados de dezembro de 2007, foi possível identificar 13 frutos que atingiram a maturidade fisiológica, após um período médio de observação de 112 dias. Para exigência fototérmica de 1.878.166,1 UF, encontrou-se Tb de 10 °C, valor consistente com os apresentados na literatura para a cultivar de manga, o que comprova a eficiência do método que combina a ação da temperatura e do fotoperíodo sobre a maturação dos frutos e que confere um caráter mais racional que o método tradicional da soma térmica.In this study was to determine the lower base temperature (Tb for Alfa mango fruit, using the photothermal units (PTU method in cerrado conditions. The meteorological data for the study were acquired from "Padre Ricardo Remetter" meteorological station located at Santo Antonio do Leverger, MT, Brazil (15,8° S and 56,1° W, 140 m, and the fruit data was acquired by sensorial evaluation of mango fruit maturation state. The Tb was determined by less variability of the coefficient of variation (cv method applied to the PTU sum, from flowering to harvest, simulated for

  6. Clinical Experience of Interferon Alfa-2a Treatment for Refractory Uveitis in Behçet's Disease.

    Science.gov (United States)

    Park, Ji-Youn; Chung, Yoo-Ri; Lee, Kihwang; Song, Ji Hun; Lee, Eun-So

    2015-07-01

    Behçet's disease (BD) involves multisystem vasculitis of unknown origin. Ocular manifestations of BD mostly include bilateral panuveitis and retinal vasculitis, which are very challenging to treat. Interferon alfa-2a (IFN) has been recently introduced for treating refractory Behçet uveitis, mainly in Germany and Turkey. Nonetheless, there is so far no consensus about the ideal treatment regimen of IFN for Behçet uveitis. We report our experience of IFN treatment in five Korean BD patients with refractory uveitis. All patients complained of oral ulcers; one patient had a positive pathergy test and 2 showed the presence of HLA-B51. Immunosuppressive agents used prior to IFN treatment included cyclosporine and methotrexate. The IFN treatment was commenced with a dose of 6-9 MIU/day for 7 days, adjusted according to individual ocular manifestations, tapered down to 3 MIU three times in a week, and then discontinued. All patients showed positive response to IFN treatment; 50% of them showed complete response without additional major ocular inflammation during the follow-up period. Other BD symptoms also improved after IFN treatment in most cases. After treatment, the relapse rate and the required dose of oral corticosteroid were decreased in most cases, showing a significant steroid-sparing effect. However, the visual acuity was not improved in most cases due to irreversible macular sequelae. Despite the small sample size of this study, we suggest that, in Korean patients, IFN is an effective treatment modality for BD uveitis as was observed in German and Turkish patients.

  7. Diversidad alfa y beta de los artrópodos en diferentes ambientes del Parque Nacional Los Cardones, Salta (Argentina

    Directory of Open Access Journals (Sweden)

    María Belén Cava

    2013-12-01

    Full Text Available El Parque Nacional Los Cardones ubicado en la provincia de Salta protege las ecorregiones de Puna, Monte y Pastizal Altoandino Nublado de la Yungas. Nuestro objetivo es evaluar la diversidad alfa y beta de artrópodos en las ecorregiones del Parque. Se muestrearon tres sitios en cada ecorregión utilizando Pit-fall y G-Vac. Se calcularon estimadores no paramétricos de riqueza de especies, la diversidad entre ecorregiones se comparó a través de los “perfiles de diversidad” y “números efectivos de especies”, se analizó el recambio de especies y la complementariedad entre las ecorregiones y sitios de una misma ecorregión. Se registraron 469 spp/morfoespecies, la diversidad en el Parque fue alta, siendo mayor en los Pastizal Altoandino Nublado, y la más baja en la Puna. El inventario llegó al 81% de completitud. El recambio de especies entre ecorregiones fue alto, de esa manera los diferentes ambientes del Parque contribuyen a conservar la diversidad regional de artrópodos. Las ensambles de artrópodos en sitios de una misma ecorregión mostraron mayor similitud entre sí que con sitios más distantes. Se pudo reconocer tres grupos de artrópodos (arañas, dípteros e himenópteros que son diversos y abundantes, los que podrían ser utilizados en futuros estudios como grupos focales.

  8. Expression of interferon regulatory factor 4 in chronic myeloid leukemia: correlation with response to interferon alfa therapy.

    Science.gov (United States)

    Schmidt, M; Hochhaus, A; König-Merediz, S A; Brendel, C; Proba, J; Hoppe, G J; Wittig, B; Ehninger, G; Hehlmann, R; Neubauer, A

    2000-10-01

    Mice experiments have established an important role for interferon regulatory factor (IRF) family members in hematopoiesis. We wanted to study the expression of interferon regulatory factor 4 (IRF4) in various hematologic disorders, especially chronic myeloid leukemia (CML), and its association with response to interferon alfa (IFN-alpha) treatment in CML. Blood samples from various hematopoietic cell lines, different leukemia patients (70 CML, 29 acute myeloid leukemia [AML], 10 chronic myelomonocytic leukemia [CMMoL], 10 acute lymphoblastic leukemia, and 10 chronic lymphoid leukemia patients), and 33 healthy volunteers were monitored for IRF4 expression by reverse transcriptase polymerase chain reaction. Then, with a focus on CML, the IRF4 level was determined in sorted cell subpopulations from CML patients and healthy volunteers and in in vitro-stimulated CML cells. Furthermore, IRF4 expression was compared in the CML samples taken before IFN-alpha therapy and in 47 additional CML samples taken during IFN-alpha therapy. IRF4 expression was then correlated with cytogenetic response to IFN-alpha. IRF4 expression was significantly impaired in CML, AML, and CMMoL samples. The downregulation of IRF4 in CML samples was predominantly found in T cells. In CML patients during IFN-alpha therapy, a significant increase in IRF4 levels was detected, and this was also observed in sorted T cells from CML patients. The increase seen during IFN-alpha therapy was not due to different blood counts. In regard to the cytogenetic response with IFN-alpha, a good response was associated with high IRF4 expression. IRF4 expression is downregulated in T cells of CML patients, and its increase is associated with a good response to IFN-alpha therapy. These data suggest IRF4 expression as a useful marker to monitor, if not predict, response to IFN-alpha in CML.

  9. Evaluation of treatment response to enzyme replacement therapy with Velaglucerase alfa in patients with Gaucher disease using whole-body magnetic resonance imaging.

    Science.gov (United States)

    Laudemann, K; Moos, L; Mengel, E; Lollert, A; Hoffmann, C; Brixius-Huth, M; Wagner, D; Düber, C; Staatz, G

    2016-03-01

    This was a retrospective data analysis to evaluate the treatment response to enzyme replacement therapy (ERT) with Velaglucerase alfa using whole-body magnetic resonance imaging (MRI). A baseline and follow-up MRI were performed on 18 Gaucher Type 1 patients at an interval of 11.6 months. The MRI score systems determined the Bone-Marrow-Burden (BMB) score, the Düsseldorf-Gaucher score (DGS), and the Vertebra-Disc-Ratio (VDR). The Severity Score Index Type 1 (GD-DS3) was also assessed. The baseline MRI medians were: BMB, 7.00; DGS, 3.00; and VDR: 1.70; while, the follow-up MRI medians were: BMB, 7.00; DGS, 3.00; and VDR: 1.73. The baseline GD-DS3 median was 2.40 (BMB excl.: 0.50) and the follow-up median was 2.00 (BMB excl.: 0.50). There was weak statistical significance with the Wilcoxon signed-rank test for the DGS (p=0.034) and GD-DS3 (p=0.047) between both MRIs. Velaglucerase alfa therapy is a effective long-term treatment for Gaucher Type 1 patients who are newly diagnosed or switching therapies. Measurements with whole-body MRI and an objective scoring system were reliable tools for detecting early stage bone marrow activity. Further research is needed to evaluate the "Booster-Effect" of Velaglucerase alfa therapy in Gaucher skeletal disease. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Alpha absolute power: motor learning of practical pistol shooting Potência absoluta de alfa: aprendizagem motora do tiro prático de pistola

    Directory of Open Access Journals (Sweden)

    Clayton Amaral Domingues

    2008-06-01

    Full Text Available The present study aimed at investigating changes in behavior (shooting precision and electrophysiological variables (absolute alpha power during the motor learning of practical pistol shooting. The sample was composed of 23 healthy subjects, right-handed, male, between 18 and 20 years of age. The task consisted of four learning blocks. A One-way ANOVA with repeated measures and a post hoc analysis were employed to observe modifications on behavioral and electrophysiological measures (pO presente estudo teve por objetivo investigar alterações nas variáveis comportamentais (precisão do tiro e eletrofisiológicas (potência absoluta de alfa durante o aprendizado motor do tiro prático de pistola. A amostra constituiu-se de 20 sujeitos saudáveis, destros, sexo masculino, faixa etária entre 18 e 20 anos. A tarefa consistiu de quatro blocos de aprendizagem. A análise estatística das variáveis comportamentais e eletrofisiológicas foram realizadas por meio de uma ANOVA one-way e uma análise post hoc (p<0,05. Os resultados demonstraram diferenças significativas entre os blocos em função do aprendizado motor, bem como uma sensível melhora na precisão do tiro de ambos os blocos. Foi observada uma diminuição na potência de alfa em todos os eletrodos analisados durante a execução da tarefa, quando comparados aos blocos de linha de base e controle da aprendizagem. Os achados sugerem que a potência em alfa diminui devido o aprendizado motor quando sujeitos estão engajados na execução de uma tarefa motora complexa.

  11. An Alpha spectrometer for measuring radon daughter individual activity concentration; Spettrometro Alfa per la misura delle concentrazioni individuali in attivita' della progenie del radon

    Energy Technology Data Exchange (ETDEWEB)

    Berico, M.; Formignani, M. [ENEA, Div. Protezione dell' Uomo e degli Ecosistemi, Centro Ricerche E. Clementel, Bologna (Italy); Mariotti, F. [Bologna Univ., Bologna (Italy). Dipt. di Fisica

    2001-07-01

    In the frame of the program of the Institute for Radiation Protection of ENEA, related to the evaluation of dose from radon and thoron progeny, an alpha spectrometer for the continuous air monitoring (CAM type) of radon and thoron has been realized. The constructive characteristics of the device are here presented together with energy and efficiency calibration. The device allows, by means of a screen type diffusion battery and a filter, to determinate the single radioactivity of each radionuclide of the progeny selecting them in relation to their diffusive behaviour (dichotomous particle size selection). The three-count filter method has been employed to measure the concentrations of {sup 218}Po, {sup 214}Pb and {sup 214}Bi in air. Radon and thoron effective doses using a dosimetric, instead of an epidemiologic approach, will be then evaluated. [Italian] Presso l'Istituto per la Radioprotezione, nell'ambito del programma di valutazione di dose da radon e' stato progettato e realizzato uno spettrometro alfa per il monitoraggio continuo in aria (CAM) della progenie del radon e del toron. Le caratteristiche costruttive dello strumento permettono, tramite l'utilizzo di batterie a diffusione a reti, di determinare l'attivita' individuale della progenie per diverse dimensioni granulometriche in particolare per la frazione attaccata e non al particolato amosferico con un taglio granulometrico di qualche nanometro. E' stato inoltre applicato un metodo spettrometrico a tre conteggi per il calcolo delle concentrazioni individuali della progenie del radon, {sup 218}Po, {sup 214}Pb and {sup 214}Bi, effettuando un conteggio alfa di {sup 218}Po e due conteggi alfa di {sup 214}Po. Tale informazione consentira' una valutazione della dose di radon utilizzando il modello dosimetrico in alternativa a quello epidemiologico.

  12. Interferon alfa-2b, colchicine, and benzathine penicillin versus colchicine and benzathine penicillin in Behçet's disease: a randomised trial.

    Science.gov (United States)

    Demiroglu, H; Ozcebe, O I; Barista, I; Dündar, S; Eldem, B

    2000-02-19

    Sight-threatening eye involvement is a serious complication of Behçet's disease. Extraocular complications such as arthritis, vascular occlusive disorders, mucocutaneous lesions, and central-nervous-system disease may lead to morbidity and even death. We designed a prospective study in newly diagnosed patients without previous eye disease to assess whether prevention of eye involvement and extraocular manifestations, and preservation of visual acuity are possible with combination treatments with and without interferon alfa-2b. Patients were randomly assigned 3 million units interferon alfa-2b subcutaneously every other day for the first 6 months plus 1.5 mg colchicine orally daily and 1.2 million units benzathine penicillin intramuscularly every 3 weeks (n=67), or colchicine and benzathine penicillin alone (n=68). The primary endpoint was visual-acuity loss. Analysis was by intention to treat. Significantly fewer patients who were treated with interferon had eye involvement than did patients who did not receive interferon (eight vs 27, relative risk 0.21 [95% CI 0.09-0.50], p<0.001). Ocular attack rate was 0.2 (SD 0.62) per year with interferon therapy and 1.02 (1.13) without interferon therapy (p=0.0001). Visual-acuity loss was significantly lower among patients treated with interferon than in those without interferon (two vs 13, relative risk 0.13 [95% CI 0.03-0.60], p=0.003). Arthritis episodes, vascular events, and mucocutaneous lesions were also less frequent in patients treated with interferon than in those not receiving interferon. No serious side-effects were reported. Therapy with interferon alfa-2b, colchicine, and benzathine penicillin seems to be an effective regimen in Behçet's disease for the prevention of recurrent eye attacks and extraocular complications, and for the protection of vision.

  13. Estudo da Reação da Desitratação da Gipsita Em Meio Aquoso Num Reator de Batelada (parr) Para Produção de Gesso Alfa

    OpenAIRE

    Pereira, Pedro Leiz de Mendonça

    2012-01-01

    A partir da reação de desidratação da gipsita (CaSO4.2H2O) pode-se obter o Gesso (CaSO4.1/2H2O) do tipo alfa e do tipo beta, dependendo das condições nas quais ocorre a reação. A produção do gesso alfa é mais complexa, por tratar-se de um produto com características de maior valor agregado e com aplicação diferenciada. O presente trabalho visa o estudo dos aspectos termocinéticos da reação de desidratação da gipsita para obtenção do gesso alfa em meio aquoso, e procura trazer maiores informaç...

  14. Comparable pharmacokinetics and pharmacodynamics of two epoetin alfa formulations Eporon® and Eprex® following a single subcutaneous administration in healthy male volunteers

    Directory of Open Access Journals (Sweden)

    Yoon S

    2017-10-01

    Full Text Available Sumin Yoon,1 Su-jin Rhee,1 Sun Ju Heo,2 Tae Young Oh,2 Seo Hyun Yoon,1 Joo-Youn Cho,1 SeungHwan Lee,1,3 Kyung-Sang Yu1,3 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, 2Dong-A ST Co. Ltd., Seoul, 3Clinical Trials Center, Seoul National University Hospital, Seoul, Republic of Korea Purpose: This study aimed to assess and compare the pharmacokinetic (PK and pharmacodynamic (PD properties following a single subcutaneous injection of epoetin alfa (Eporon® with those of the comparator (Eprex® in healthy male subjects. Subjects and methods: A randomized, double-blind, two-sequence, crossover study was conducted. Subjects were randomly assigned to receive a single dose, that is, 4,000 IU, of the test or comparator epoetin alfa. After 4 weeks, all subjects received the alternative formulation. The primary PK parameters, maximum observed concentration (Cmax and area under the curve extrapolated to infinity (AUCinf, were calculated with the serum erythropoietin (EPO concentrations from blood samples collected for 144 h after dosing. The reticulocyte, hematocrit, hemoglobin and red blood cell counts were measured up to 312 h as PD markers. The primary PD parameters, maximum observed effect (Emax and area under the effect curve (AUEC, were obtained from the baseline-corrected reticulocyte count. The serum EPO concentration and the reticulocyte count were used to assess the concentration–response relationship. The tolerability and immunogenicity profiles were assessed together. Results: Forty-two subjects completed the study. The mean EPO concentration–time profiles were comparable between the two formulations. The geometric mean ratios (90% CI of the Cmax and AUCinf were 0.908 (0.843–0.978 and 1.049 (0.999–1.101, respectively, both of which were within the regulatory range of 0.80–1.25. Additionally, the PD and tolerability profiles were similar between the two

  15. Influência da vitamina D associada ao interferon alfa-peguilado e ribavirina na resposta virológica sustentada na hepatite C crônica

    OpenAIRE

    Luiza Vitelo ANDRIGHETTO; Jacqueline Shaurich dos SANTOS; Graziella NICOLETTI; Patricia Martins BOCK

    2016-01-01

    O objetivo deste trabalho foi avaliar a influência da vitamina D no tratamento de hepatite C com interferon-alfa peguilado e ribavirina. Foram utilizados artigos científicos relevantes publicados entre os anos de 2000 e 2015. Em diversos estudos foi observado que níveis mais elevados de vitamina D estavam associados à rápida resposta ao tratamento e à maior taxa de RVS, sugerindo que a deficiência de vitamina D pode estar ligada a uma falta de resposta ao tratamento antiviral. A i...

  16. Purificación y caracterización de alfa-amilasa de penicillium commune producida mediante fermentación en fase sólida

    OpenAIRE

    Espinel, Esperanza; López, Elizabeth

    2010-01-01

    Este estudio reporta la purificación y caracterización parcial de una alfa-amilasa producida por Penicillium commune mediante fermentación en fase sólida, empleandoyuca blanca colombiana (Manihot esculenta Crantz) como soporte. La enzima fue purificada por precipitación fraccionada con sulfato de amonio, cromatografía de intercambio aniónico (DEAE-Sephadex A-50), cromatografía de filtración por gel (Sephadex G-75) y cromatografía de intercambio catiónico (CM-Sephadex C-50) obteniendo una acti...

  17. Long-term outcome of hepatitis B e antigen-positive patients with compensated cirrhosis treated with interferon alfa. European Concerted Action on Viral Hepatitis (EUROHEP)

    DEFF Research Database (Denmark)

    Fattovich, G; Giustina, G; Realdi, G

    1997-01-01

    The aim of this study was to evaluate whether interferon alfa (IFN-alpha) treatment-associated virological and biochemical remission improves survival in a cohort of 90 white patients with compensated cirrhosis caused by hepatitis B (Child A) followed for a mean period of 7 years. Inclusion...... criteria were biopsy-proven cirrhosis, hepatitis B e antigen (HBeAg) positivity, abnormal serum aminotransferase levels, exclusion of hepatitis delta virus, and absence of complications of cirrhosis. Of the 40 IFN-treated patients, 27 (67%) showed sustained HBeAg loss with alanine aminotransferase (ALT...

  18. Seguridad de la terapia de interferón alfa 2b recombinante más ribavirina en la hepatitis crónica C

    OpenAIRE

    Sánchez Rodríguez, Yoan Antonio; Arús Soler, Enrique; López Saura, Pedro; Nodarse Cuní, Hugo

    2011-01-01

    INTRODUCCIÓN: la hepatitis crónica C ha adquirido rango de pandemia. El virus de la hepatitis C se ha convertido en la causa principal de hepatitis crónica, cirrosis hepática, hepatocarcinoma, y trasplante de hígado a nivel mundial. OBJETIVO: identificar los efectos adversos asociados a la terapia combinada interferón alfa 2b recombinante más ribavirina durante la evolución del tratamiento y hasta 8 semanas después de finalizado, así como los principales efectos asociados a salidas temporales...

  19. Efeitos do levosimendan sobre TNF-alfa, PNB e MMP-1 em pacientes com insuficiência cardíaca com anemia

    Directory of Open Access Journals (Sweden)

    Mutlu Büyüklü

    2012-07-01

    Full Text Available FUNDAMENTO: O levosimendan é conhecido pelo seu efeito bilateral de fortalecimento contração das miofibrilas sem aumentar a demanda de oxigênio no miocárdio. A anemia é uma deterioração que causa aumento da dosagem de fármacos em pacientes com insuficiência cardíaca. OBJETIVO: No presente estudo comparamos a eficácia do tratamento com levosimendan em pacientes com insuficiência cardíaca descompensada com ou sem anemia. MÉTODOS: Foram incluídos no estudo 23 pacientes anêmicos com insuficiência cardíaca classe 3 ou 4, segundo a New York Heart Association (NYHA e fração de ejeção abaixo de 35%. Outros 23 pacientes com o mesmo diagnóstico cardíaco, mas sem anemia, serviu como grupo controle. Ao tratamento da insuficiência cardíaca tradicional desses pacientes foi acrescido um tratamento de 24 horas de levosimendan. Amostras foram tomadas para dosar os níveis séricos do fator de necrose tumoral alfa sérico (TNF-alfa, peptídeo natriurético cerebral aminoterminal (NT-proPNB e metaloproteinase da matriz 1 (MMP-1, antes e após a administração. RESULTADOS: Não houve diferença significativa entre os níveis séricos de TNF-alfa e MMP-1, antes e depois do tratamento (p > 0,05. Embora o nível de NT-proBNP tenha diminuído em ambos os grupos após o tratamento, não foi estatisticamente significativo (p = 0,531 e p = 0,913 para os grupos de anemia e de controle, respectivamente. Uma restauração significativa da capacidade funcional foi observada em ambos os grupos avaliados, de acordo com a NYHA (p < 0,001 e p = 0,001 para os grupos de anemia e controle, respectivamente. CONCLUSÃO: O tratamento com levosimendan apresenta efeitos semelhantes em pacientes com insuficiência cardíaca, com anemia e sem anemia. No entanto, o efeito precoce desse tratamento sobre os níveis de TNF-alfa, NT-proPNB e MMP-1 não é evidente. Ele oferece uma melhora significativa na capacidade funcional, sem a influência da anemia.

  20. AlphaCI: un programa de cálculo de intervalos de confianza para el coeficiente alfa de Cronbach AlphaCI: a computer program for computing confidence intervals around Cronbach's alfa coefficient

    Directory of Open Access Journals (Sweden)

    Rubén Ledesma

    2004-06-01

    Full Text Available El coeficiente alfa de Cronbach es el modo más habitual de estimar la fiabilidad de pruebas basadas en Teoría Clásica de los Test. En dicha estimación, los investigadores usualmente omiten informar intervalos de confianza para el coeficiente, un aspecto no solo recomendado por los especialistas, sino también requerido explícitamente en las normas editoriales de algunas revistas especializadas. Esta situación puede atribuirse a que los métodos de estimación de intervalos de confianza son poco conocidos, además de no estar disponibles al usuario en los programas estadísticos más populares. Así, en este trabajo se presenta un programa desarrollado dentro del sistema estadístico ViSta que permite calcular intervalos de confianza basados en el enfoque clásico y mediante la técnica bootstrap. Se espera promover la inclusión de intervalos de confianza para medidas de fiabilidad, facilitando el acceso a las herramientas necesarias para su aplicación. El programa es gratuito y puede obtenerse enviando un mail de solicitud al autor del trabajo.Cronbach's alpha coefficient is the most popular way of estimating reliability in measurement scales based on Classic Test Theory. When estimating it, researchers usually omit to report confidence intervals of this coefficient, as it is not only recommended by experts, but also required by some journal's guidelines. This situation is because the different methods of estimating confidence intervals are not well-known by researchers, as well as they are not being available among the most popular statistical packages. Therefore, this paper describes a computer program integrated into the ViSta statistical system, which allows computing confidence intervals based on the classical approach and using bootstrap technique. It is hoped that this work promotes the inclusion of confidence intervals of reliability measures, by increasing the availability of the required computer tools. The program is free and

  1. O papel do Fator de Necrose Tumoral Alfa (TNF-alfa no processo de erosão óssea presente no colesteatoma adquirido da orelha média The role of Tumor Necrosis Factor -Alpha (TNF- alpha in bone resorption present in middle ear cholesteatoma

    Directory of Open Access Journals (Sweden)

    Rodrigo Faller Vitale

    2007-02-01

    Full Text Available O colesteatoma adquirido da orelha média causa erosão óssea, com altas taxas de morbidade e mortalidade. O TNF-alfa (TNF-alfa lambda uma das principais citocinas envolvidas neste processo. OBJETIVO: Avaliar o papel do TNF-alfa na reabsorsão óssea e a ação dele no colesteatoma. MATERIAL E MÉTODOS: Foi realizado um levantamento e uma revisão crítica da literatura. RESULTADOS: Todos os autores estudados concordam com a importância do TNF-alfa no processo de reabsorção óssea presente no colesteatoma e com o grau de destruição observado. Diferentes trabalhos demonstraram que o TNF-alfa é capaz de provocar erosão óssea, através de diferentes vias de ação. Ele pode estimular a diferenciação e a maturação dos osteoclastos ou, ainda, agir na matriz óssea expondo-a à ação dos osteoclastos. Existe a possibilidade de inibir a ação do TNF-alfa, diminuindo seus efeitos e prevenindo a perda óssea em doenças como a artrite reumatóide. Não existe, entretanto, trabalhos específicos em colesteatoma. Não existe consenso sobre a sua localização. Estas diferenças, provavelmente, ocorrem devido à distribuição dos receptores. CONCLUSÃO: O TNF-alfa, presente no colesteatoma promove a reabsorsão óssea, juntamente com outras citocinas (RANKL e IL-1, estando relacionado com a presença de complicações.Cholesteatoma may cause bone erosion, with high morbidity and mortality rates. Tumor Necrosis Factor -Alpha (TNF-a is one of the main cytokines involved in this process. Our goal was to evaluate the role of TNF-a in Bone Resorption and its effect on cholesteatoma. MATERIAL AND METHODS: analysis and critical literature review. RESULTS: Different studies have demonstrated that TNF-a is capable of causing bone erosion. It may stimulate the differentiation and maturation of osteoclasts or it may act on the bone matrix, exposing it to the action of the osteoclasts. It is possible to inhibit TNF-a, reducing its effects and prevent

  2. Enzymatic hydrolysis of pretreated Alfa fibers (Stipa tenacissima) using β-d-glucosidase and xylanase of Talaromyces thermophilus from solid-state fermentation.

    Science.gov (United States)

    Mallek-Fakhfakh, Hanen; Fakhfakh, Jawhar; Walha, Kamel; Hassairi, Hajer; Gargouri, Ali; Belghith, Hafedh

    2017-10-01

    This work aims at realizing an optimal hydrolysis of pretreated Alfa fibers (Stipa tenacissima) through the use of enzymes produced from Talaromyces thermophilus AX4, namely β-d-glucosidase and xylanase, by a solid state fermentation process of an agro-industrial waste (wheat bran supplemented with lactose). The carbon source was firstly selected and the optimal values of three other parameters were determined: substrate loading (10g), moisture content (85%) and production time (10days); which led to an optimized enzymatic juice. The outcome was then supplemented with cellulases of T. reesei and used to optimize the enzymatic saccharification of alkali-pretreated Alfa fibers (PAF). The maximum saccharification yield of 83.23% was achieved under optimized conditions (substrate concentration 3.7% (w/v), time 144h and enzyme loading of 0.8 FPU, 15U CMCase, 60U β-d-glucosidase and 125U xylanase).The structural modification of PAF due to enzymatic saccharification was supported by the changes of morphologic and chemical composition observed through macroscopic representation, FTIR and X-Ray analysis. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Measurement of elastic proton-proton scattering at $\\sqrt{s} = 7$ TeV with the ALFA sub-detector of ATLAS at the LHC

    CERN Document Server

    Kreutzfeldt, Kristof; Stenzel, Hasko

    The ATLAS experiment with the ALFA sub-detector, provides a unique opportunity to measure elastic proton--proton scattering at the LHC at a centre-of-mass energy of $\\sqrt{s} = 7$ TeV, that has never been reached before. The ALFA detector is a tracking detector housed in Roman Pots, which makes it possible to measure elastically scattered protons down to very small scattering angles. From the proton tracks, measured during a LHC fill with special $\\beta^{*} = 90$ m beam optics, the differential elastic cross-section as a function of the four-momentum transfer squared $t$ is determined, and the total hadronic cross-section $\\sigma_\\text{tot}$, the nuclear slope parameter $B$ and further derived quantities are extracted by utilizing the optical theorem. The total hadronic cross-section is a fundamental parameter of strong interaction depending on the centre-of-mass energy. It has been measured for more than 50 years at different energies and accelerators, where a rise with energy was observed. A newly developed...

  4. Epoetin alfa 40000 U once weekly and intravenous iron supply in solid tumor patients: early increase of hemoglobin level during chemotherapy

    International Nuclear Information System (INIS)

    Lalle, M.; Antimi, M.; Pistillucci, G.; D'Aprile, M.

    2005-01-01

    The objective of this observational study was the early evaluation of the impact, a week after the first administration of epoetin alfa 40000 U once weekly and i.v. dose of 62.5 mg sodium ferric gluconate for seven days in improving hemoglobin levels in cancer patients affected by mild/moderate or severe anemia during chemotherapy. Twenty patients affected by solid tumors who received epoetin alfa 40000 U once weekly and daily i.v. sodium ferric gluconate for one week were evaluated: 90% of the patients showed hemoglobin increase, with a median level of hemoglobin increase of 0.73 g/L from baseline, and 50% of them showing a hemoglobin increase > 1 gr/L. The treatment was well tolerated and no adverse event was observed. The early increase of hemoglobin level from baseline is interesting and suggestive for the possibility of achieving an adequate hemoglobin level with a short-term treatment. It is still necessary to further explore the real need of iron supplementation to maintain adequate erythropoiesis prior and during epoetin therapy

  5. Efek Pemberian Asam Alfa Lipoat untuk Mencegah Lesi Aterosklerosis Aorta Abdominal pada Tikus Diabetes Mellitus Tipe 2

    Directory of Open Access Journals (Sweden)

    Ismawati ismawati

    2018-01-01

    Full Text Available Efek asam lipoat terhadap komplikasi diabetes mellitus telah banyak diteliti. Efek protektif asam lipoat (ALA terhadap aterosklerosis pada diabetes mellitus masih perlu diteliti. Penelitian ini bertujuan untuk men­getahui pencegahan lesi aterosklerosis oleh asam alfa lipoat pada tikus diabetes mellitus (DM tipe 2. Se­banyak 21 ekor tikus wistar jantan yang dibagi menjadi 3 kelompok; kelompok kontrol, kelompok DM dan kelompok DM +ALA. Induksi DM tipe 2 dilakukan dengan pemberian streptozotocin (50 mg/kg diikuti oleh nikotinamide (110 mg/kg dosis tunggal intraperitoneal. Asam lipoat diberikan peroral (60 mg/kg selama 3 minggu setelah hewan coba terdiagnosis DM. Penelitian yang merupakan penelitian eksperimental den­gan desain post test only with control ini dilakukan di Laboratorium Biokimia Fakultas Kedokteran Univer­sitas Riau bulan Juni - Oktober 2016. Hasil penelitian memperlihatkan skor aterosklerosis pada kelompok DM+ALA lebih rendah dibandingkan kelompok DM dan perbedaan ini bermakna secara statistik. Asam lipoat dapat mencegah pembentukan lesi aterosklerosis pada tikus DM tipe 2.   The Effect of Alpha Lipoic Acid in Preventing Atherosclerosis Lesion on the Abdominal Aorta of Diabetes Mellitus Type 2 Rats   AbstractVarious studies have studied the clinical use of alpha-lipoic acid (ALA for treating diabetic complica­tions. The protective effect of lipoic acid in atherosclerosis induced by diabetes mellitus type 2 (DM type 2 still needs further study. This study was aimed to investigate the protective effect of ALA in atherosclerosis induced by DM type 2. Twenty one rats were divided into 3 groups: control, DM−treated and DM+ALA-treated group. Type-2 diabetes was induced by intraperitoneal injection of streptozotocin (50 mg/kg followed by nicotinamide (110 mg/kg. ALA was administered orally at a dose of 60 mg/kg body weight/day throughout the feeding period for three weeks. This study was an experimental study with post-test only

  6. ATLASGAL-selected massive clumps in the inner Galaxy. VI. Kinetic temperature and spatial density measured with formaldehyde

    Science.gov (United States)

    Tang, X. D.; Henkel, C.; Wyrowski, F.; Giannetti, A.; Menten, K. M.; Csengeri, T.; Leurini, S.; Urquhart, J. S.; König, C.; Güsten, R.; Lin, Y. X.; Zheng, X. W.; Esimbek, J.; Zhou, J. J.

    2018-03-01

    Context. Formaldehyde (H2CO) is a reliable tracer to accurately measure the physical parameters of dense gas in star-forming regions. Aim. We aim to determine directly the kinetic temperature and spatial density with formaldehyde for the 100 brightest ATLASGAL-selected clumps (the TOP100 sample) at 870 μm representing various evolutionary stages of high-mass star formation. Methods: Ten transitions (J = 3-2 and 4-3) of ortho- and para-H2CO near 211, 218, 225, and 291 GHz were observed with the Atacama Pathfinder EXperiment (APEX) 12 m telescope. Results: Using non-LTE models with RADEX, we derived the gas kinetic temperature and spatial density with the measured para-H2CO 321-220/303-202, 422-321/404-303, and 404-303/303-202 ratios. The gas kinetic temperatures derived from the para-H2CO 321-220/303-202 and 422-321/404-303 line ratios are high, ranging from 43 to >300 K with an unweighted average of 91 ± 4 K. Deduced Tkin values from the J = 3-2 and 4-3 transitions are similar. Spatial densities of the gas derived from the para-H2CO 404-303/303-202 line ratios yield 0.6-8.3 × 106 cm-3 with an unweighted average of 1.5 (±0.1) × 106 cm-3. A comparison of kinetic temperatures derived from para-H2CO, NH3, and dust emission indicates that para-H2CO traces a distinctly higher temperature than the NH3 (2, 2)/(1, 1) transitions and the dust, tracing heated gas more directly associated with the star formation process. The H2CO line widths are found to be correlated with bolometric luminosity and increase with the evolutionary stage of the clumps, which suggests that higher luminosities tend to be associated with a more turbulent molecular medium. It seems that the spatial densities measured with H2CO do not vary significantly with the evolutionary stage of the clumps. However, averaged gas kinetic temperatures derived from H2CO increase with time through the evolution of the clumps. The high temperature of the gas traced by H2CO may be mainly caused by radiation from embedded young massive stars and the interaction of outflows with the ambient medium. For Lbol/Mclump ≳ 10 L⊙/M⊙, we find a rough correlation between gas kinetic temperature and this ratio, which is indicative of the evolutionary stage of the individual clumps. The strong relationship between H2CO line luminosities and clump masses is apparently linear during the late evolutionary stages of the clumps, indicating that LH_2CO does reliably trace the mass of warm dense molecular gas. In our massive clumps H2CO line luminosities are approximately linearly correlated with bolometric luminosities over about four orders of magnitude in Lbol, which suggests that the mass of dense molecular gas traced by the H2CO line luminosity is well correlated with star formation. Source and H2CO parameters (Tables A.1-A.7) are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/611/A6

  7. A Phase 3, multicenter, open-label, switchover trial to assess the safety and efficacy of taliglucerase alfa, a plant cell-expressed recombinant human glucocerebrosidase, in adult and pediatric patients with Gaucher disease previously treated with imiglucerase.

    Science.gov (United States)

    Pastores, Gregory M; Petakov, Milan; Giraldo, Pilar; Rosenbaum, Hanna; Szer, Jeffrey; Deegan, Patrick B; Amato, Dominick J; Mengel, Eugen; Tan, Ee Shien; Chertkoff, Raul; Brill-Almon, Einat; Zimran, Ari

    2014-12-01

    Taliglucerase alfa is a β-glucosidase enzyme replacement therapy (ERT) approved in the US and other countries for the treatment of Gaucher disease (GD) in adults and is approved in pediatric and adult patients in Australia and Canada. It is the first approved plant cell-expressed recombinant human protein. A Phase 3, multicenter, open-label, 9-month study assessed safety and efficacy of switching to taliglucerase alfa in adult and pediatric patients with GD treated with imiglucerase for at least the previous 2years. Patients with stable disease were offered taliglucerase alfa treatment using the same dose (9-60U/kg body weight) and regimen of administration (every 2weeks) as imiglucerase. This report summarizes results from 26 adult and 5 pediatric patients who participated in the trial. Disease parameters (spleen and liver volumes, hemoglobin concentration, platelet count, and biomarker levels) remained stable through 9months of treatment in adults and children following the switch from imiglucerase. All treatment-related adverse events were mild or moderate in severity and transient in nature. Exploratory parameters of linear growth and development showed positive outcomes in pediatric patients. These findings provide evidence of the efficacy and safety profile of taliglucerase alfa as an ERT for GD in patients previously treated with imiglucerase. This trial was registered at www.clinicaltrials.gov as # NCT00712348. Copyright © 2014 Elsevier Inc. All rights reserved.

  8. A randomised, double-blind, placebo-controlled, crossover study to assess the efficacy and safety of three dosing schedules of agalsidase alfa enzyme replacement therapy for Fabry disease.

    Science.gov (United States)

    Hughes, D A; Deegan, P B; Milligan, A; Wright, N; Butler, L H; Jacobs, A; Mehta, A B

    2013-07-01

    Anecdotal reports suggest that the currently approved dosing interval of agalsidase alfa (0.2 mg/kg/2 weeks) for Fabry disease treatment is too long. This randomised, double-blind, placebo-controlled, crossover study investigated three altered dosing intervals. 18 Fabry patients received three agalsidase alfa dosing schedules, each for four weeks (A: 0.2 mg/kg∗2 weeks, B: 0.1 mg/kg/week, C: 0.2 mg/kg/week). Health state, pain levels, sweat volume and latency and plasma and urinary globotriaosylceramide levels were recorded throughout the study. No significant differences were found among the schedules for the primary efficacy outcome of self-assessed health state, or for pain scores. A trend toward increased sweat volume on QSART testing, and reduced urine globotriaosylceramide concentration were seen with treatment schedule C. Agalsidase alfa was safe and well tolerated with all schedules. In conclusion, the primary analyses did not find weekly infusions of agalsidase alfa to be statistically better than the approved dosing schedule however the data indicates that further studies with more patients over a longer period are required to more accurately determine the optimum dose and schedule. Copyright © 2013 Elsevier Inc. All rights reserved.

  9. Epoetin Alfa Injection

    Science.gov (United States)

    ... cannot be used to treat pregnant or nursing women or babies. The single use vials do not contain benzyl alcohol and may be used to treat pregnant or nursing women or babies, but they are only safe to ...

  10. FibroTest is an independent predictor of virologic response in chronic hepatitis C patients retreated with pegylated interferon alfa-2b and ribavirin in the EPIC³ program.

    Science.gov (United States)

    Poynard, Thierry; Munteanu, Mona; Colombo, Massimo; Bruix, Jordi; Schiff, Eugene; Terg, Ruben; Flamm, Steven; Moreno-Otero, Ricardo; Carrilho, Flair; Schmidt, Warren; Berg, Thomas; McGarrity, Thomas; Heathcote, E Jenny; Gonçales, Fernando; Diago, Moises; Craxi, Antonio; Silva, Marcelo; Boparai, Navdeep; Griffel, Louis; Burroughs, Margaret; Brass, Clifford; Albrecht, Janice

    2011-02-01

    EPIC-3 is a prospective, international study that has demonstrated the efficacy of PEG-IFN alfa-2b plus weight-based ribavirin in patients with chronic hepatitis C and significant fibrosis who previously failed any interferon-alfa/ribavirin therapy. The aim of the present study was to assess FibroTest (FT), a validated non-invasive marker of fibrosis in treatment-naive patients, as a possible alternative to biopsy as the baseline predictor of subsequent early virologic (EVR) and sustained virologic response (SVR) in previously treated patients. Of 2312 patients enrolled, 1459 had an available baseline FT, biopsy, and complete data. Uni- (UV) and multi-variable (MV) analyses were performed using FT and biopsy. Baseline characteristics were similar as in the overall population; METAVIR stage: 28% F2, 29% F3, and 43% F4, previous relapsers 29%, previous PEG-IFN regimen 41%, high baseline viral load (BVL) 64%. 506 patients (35%) had undetectable HCV-RNA at TW12 (TW12neg), with 58% achieving SVR. The accuracy of FT was similar to that in naive patients: AUROC curve for the diagnosis of F4 vs F2=0.80 (p<0.00001). Five baseline factors were associated (p<0.001) with SVR in UV and MV analyses (odds ratio: UV/MV): fibrosis stage estimated using FT (4.5/5.9) or biopsy (1.5/1.6), genotype 2/3 (4.5/5.1), BVL (1.5/1.3), prior relapse (1.6/1.6), previous treatment with non-PEG-IFN (2.6/2.0). These same factors were associated (p ≤ 0.001) with EVR. Among patients TW12neg, two independent factors remained highly predictive of SVR by MV analysis (p ≤ 0.001): genotype 2/3 (odds ratio=2.9), fibrosis estimated with FT (4.3) or by biopsy (1.5). FibroTest at baseline is a possible non-invasive alternative to biopsy for the prediction of EVR at 12 weeks and SVR, in patients with previous failures and advanced fibrosis, retreated with PEG-IFN alfa-2b and ribavirin. Copyright © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

  11. Peginterferon alfa-2b and weight-based or flat-dose ribavirin in chronic hepatitis C patients: a randomized trial.

    Science.gov (United States)

    Jacobson, Ira M; Brown, Robert S; Freilich, Bradley; Afdhal, Nezam; Kwo, Paul Y; Santoro, John; Becker, Scott; Wakil, Adil E; Pound, David; Godofsky, Eliot; Strauss, Robert; Bernstein, David; Flamm, Steven; Pauly, Mary Pat; Mukhopadhyay, Pabak; Griffel, Louis H; Brass, Clifford A

    2007-10-01

    This prospective, multicenter, community-based and academic-based, open-label, investigator-initiated, U.S. study evaluated efficacy and safety of pegylated interferon (PEG-IFN) alfa-2b plus a flat or weight-based dose of ribavirin (RBV) in adults with chronic hepatitis C. Patients (n = 5027) were randomly assigned to receive PEG-IFN alfa-2b 1.5 microg/kg/week plus flat-dose (800 mg/day) or weight-based (800-1400 mg/day) RBV for 48 weeks (patients with genotype 1, 4, 5, or 6) and for 24 or 48 weeks (genotype 2/3 patients). Primary end point was sustained virologic response (undetectable [<125 IU/mL] serum hepatitis C virus RNA at 24-week follow-up). Sustained virologic response, but not end-of-treatment, rates were significantly higher with weight-based than with flat-dose RBV (44.2% versus 40.5%; P = 0.008). Sustained virologic response rates by intention-to-treat analysis were 34.0% and 28.9%, respectively, in genotype 1 patients (P = 0.005) and 31.2% and 26.7%, respectively, in genotype 1 patients with high baseline viral load (P = 0.056). In genotype 2/3 patients, rates were not significantly different (61.8% and 59.5%, respectively) regardless of treatment duration. Besides greater hemoglobin reductions with weight-based RBV, safety profiles were similar across RBV dosing groups, including the 1400-mg/day group. PEG-IFN alfa-2b plus weight-based RBV is more effective than flat-dose RBV, particularly in genotype 1 patients, providing equivalent efficacy across all weight groups. RBV 1400 mg/day is appropriate for patients 105 to 125 kg. For genotype 2/3 patients, 24 weeks of treatment with flat-dose RBV is adequate; no evidence of additional benefit of extending treatment to 48 weeks was demonstrated.

  12. Multicenter, noninterventional, post-marketing surveillance study to evaluate dosing of recombinant human follicle-stimulating hormone using the redesigned follitropin alfa pen in women undergoing ovulation induction

    Directory of Open Access Journals (Sweden)

    Nawroth F

    2015-04-01

    Full Text Available Frank Nawroth,1 Andreas Tandler-Schneider,2 Wilma Bilger3 1Centre for Reproductive and Prenatal Medicine, Endocrinology and Osteology, Hamburg, Germany; 2Center for Reproductive Medicine, Fertility Center Berlin, Berlin, Germany; 3Medical Affairs, Fertility, Endocrinology and General Medicine, Merck Serono GmbH, Darmstadt, Germany (an affiliate of Merck KGaA, Darmstadt, Germany Abstract: This prospective, noninterventional, post-marketing surveillance study evaluated doses of recombinant human follicle-stimulating hormone (r-hFSH using the redesigned follitropin alfa pen in women who were anovulatory or oligomenorrheic and undergoing ovulation induction (OI alone or OI with intrauterine insemination. The primary endpoint was the proportion of patients who achieved monofollicular or bifollicular development (defined as one or two follicles 15 mm. Secondary endpoints included characteristics of ovulation stimulation treatment, such as mean total and mean daily r-hFSH doses. Data were analyzed for 3,193 patients from 30 German fertility centers. The proportion of patients with monofollicular or bifollicular development was 71.1% (n=2,270 of a total of 3,193 patients; intent-to-treat population. The mean±standard deviation total and daily doses of r-hFSH were 696.9±542.5 IU and 61.7±29.4 IU, respectively. The three doses prescribed most frequently were: 37.5 IU (n=703 from N=3,189; 22.0%, 50.0 IU (n=1,056 from N=3,189; 33.1%, and 75.0 IU (n=738 from N=3,189; 23.1% on the first day of stimulation; and 37.5 IU (n=465 from N=3,189; 14.6%, 50.0 IU (n=922 from N=3,189; 28.9%, and 75.0 IU (n=895 from N=3,189; 28.1% on the last day of stimulation. This noninterventional, post-marketing surveillance study found that monofollicular or bifollicular development was achieved in 71% of patients studied and the small dose increment (12.5 IU of the redesigned follitropin alfa pen allowed individualized treatment of women undergoing OI. Keywords: ovulation

  13. PURIFICACIÓN Y CARACTERIZACIÓN DE alfa-AMILASA DE PENICILLIUM COMMUNE PRODUCIDA MEDIANTE FERMENTACIÓN EN FASE SÓLIDA

    Directory of Open Access Journals (Sweden)

    Esperanza Espinel

    2010-03-01

    Full Text Available Este estudio reporta la purificación y caracterización parcial de una alfa-amilasa producida por Penicillium commune mediante fermentación en fase sólida, empleandoyuca blanca colombiana (Manihot esculenta Crantz como soporte. La enzima fue purificada por precipitación fraccionada con sulfato de amonio, cromatografía de intercambio aniónico (DEAE-Sephadex A-50, cromatografía de filtración por gel (Sephadex G-75 y cromatografía de intercambio catiónico (CM-Sephadex C-50 obteniendo una actividad específica final de 314,82 U/mg, un grado de purificación del orden de 62 y un rendimiento de 9%. La purificación hasta la homogeneidad fue confirmada por SDS-PAGE. El peso molecular estimado fue 35 kDa. La enzima mostró máxima actividad de hidrólisis de almidón soluble con pH 6,0, y estabilidad en un intervalo de pH de 5,0-7,0. La estabilidad térmica de la enzima se presentó en el intervalo de temperatura 0-50 °C y su temperatura óptima fue 70 °C. Los iones Ca2+,Ba2+ y Ag+ aumentaron significativamente la actividad de la enzima, siendo el ión Ca2+ el que tuvo el más alto poder activador. Cu2+ no alteró significativamente la actividad de la enzima, mientras que Li+ y Fe3+ la disminuyeron ligeramente (13%, y Co2+ y Hg2+ la disminuyeron 25% y 40% respectivamente. Los valores de Km y Vmáx fueron calculados usando la linealización de Lineweaver- Burk, con el resultado Km= 0,48 mg/mL y Vmáx = 5,85 micromol glucosa/min. Entre los principales productos de hidrólisis del almidón de yuca se encuentran la maltosa y la glucosa, este resultado proporciona evidencia de que la enzima es capaz de romper los enlaces glicosídicos alfa-1,4 del almidón, comportamiento característico de una alfa-amilasa.

  14. A first-year dornase alfa treatment impact on clinical parameters of patients with cystic fibrosis: the Brazilian cystic fibrosis multicenter study

    Directory of Open Access Journals (Sweden)

    Tatiana Rozov

    2013-12-01

    Full Text Available OBJECTIVE: To describe the clinical impact of the first year treatment with dornase alfa, according to age groups, in a cohort of Brazilian Cystic Fibrosis (CF patients. METHODS: The data on 152 eligible patients, from 16 CF reference centers, that answered the medical questionnaires and performed laboratory tests at baseline (T0, and at six (T2 and 12 (T4 months after dornase alfa initiation, were analyzed. Three age groups were assessed: six to 11, 12 to 13, and >14 years. Pulmonary tests, airway microbiology, emergency room visits, hospitalizations, emergency and routine treatments were evaluated. Student's t-test, chi-square test and analysis of variance were used when appropriated. RESULTS: Routine treatments were based on respiratory physical therapy, regular exercises, pancreatic enzymes, vitamins, bronchodilators, corticosteroids, and antibiotics. In the six months prior the study (T0 phase, hospitalizations for pulmonary exacerbations occurred in 38.0, 10.0 and 61.4% in the three age groups, respectively. After one year of intervention, there was a significant reduction in the number of emergency room visits in the six to 11 years group. There were no significant changes in forced expiratory volume in one second (VEF1, in forced vital capacity (FVC, in oxygen saturation (SpO2, and in Tiffenau index for all age groups. A significant improvement in Shwachman-Kulczychi score was observed in the older group. In the last six months of therapy, chronic or intermittent colonization by P. aeruginosa was detected in 75.0, 71.4 and 62.5% of the studied groups, respectively, while S. aureus colonization was identified in 68.6, 66.6 and 41.9% of the cases. CONCLUSIONS: The treatment with dornase alfa promoted the maintenance of pulmonary function parameters and was associated with a significant reduction of emergency room visits due to pulmonary exacerbations in the six to 11 years age group, with better clinical scores in the >14 age group, one

  15. Seguridad de la terapia de interferón alfa 2b recombinante más ribavirina en la hepatitis crónica C

    Directory of Open Access Journals (Sweden)

    Yoan Antonio Sánchez Rodríguez

    2011-03-01

    Full Text Available INTRODUCCIÓN: la hepatitis crónica C ha adquirido rango de pandemia. El virus de la hepatitis C se ha convertido en la causa principal de hepatitis crónica, cirrosis hepática, hepatocarcinoma, y trasplante de hígado a nivel mundial. OBJETIVO: identificar los efectos adversos asociados a la terapia combinada interferón alfa 2b recombinante más ribavirina durante la evolución del tratamiento y hasta 8 semanas después de finalizado, así como los principales efectos asociados a salidas temporales o definitivas de esta terapia. MÉTODOS: estudio de farmacovigilancia cuya serie estuvo conformada por 122 pacientes con hepatitis crónica C atendidos en el Instituto de Gastroenterología desde mayo de 2001 hasta mayo de 2006. Se utilizó interferón alfa 2b recombinante (3 millones de unidades 3 veces por semana más ribavirina (1 000 o 1 200 mg diarios en dependencia del peso corporal durante 48 semanas. RESULTADOS: el 88,5 % del total de casos presentó efectos adversos; de ellos el 79,5 % correspondió al síndrome seudogripal, seguido de manifestaciones hematológicas, neuropsiquiátricas, gastrointestinales, entre otras menos frecuentes. El 6,6 % de la serie presentó salidas temporales del tratamiento por efecto adverso distinto de la anemia y 4 pacientes, salidas definitivas del estudio, tres por anemia hemolítica severa y uno con hipertiroidismo no controlable. CONCLUSIONES: la terapia combinada interferón alfa 2b recombinante más ribavirina resulta segura, donde el mayor número de casos presentó síndrome seudogripal como efecto adverso más frecuente. Las manifestaciones hematológicas asociadas a las salidas definitivas del estudio permitieron recomendar seguimiento estricto de la hemoglobina y profundizar en el diagnóstico y tratamiento de los principales efectos adversos presentes en otros sistemas y asociados a esta terapia.

  16. Espectroscopia Mössbauer e refinamento estrutural no sistema cerâmico isomórfico (alfa-Fe2O3-(alfa-Al2O 3 Mössbauer spectroscopy and structural refinement in the isomorphic (alpha-Fe2O3-( alpha-Al2O3 ceramic system

    Directory of Open Access Journals (Sweden)

    J. A. Moreto

    2007-06-01

    Full Text Available Os multiferróicos são materiais em que duas ou três propriedades tais como ferroeletricidade, ferromagnetismo e ferroelasticidade são observadas em uma mesma fase. Em particular, os multiferróicos magnetoelétricos representam os materiais que são simultaneamente (antiferromagnéticos e ferroelétricos, com ou sem ferroelasticidade. Especificamente, o sistema hematita (alfa-Fe2O3-alumina (alfa-Al2O3 tem sido estudado, principalmente devido às suas potencialidades para aplicações em metalurgia e como catalisador na síntese de amônia. Contudo, compostos deste sistema também podem apresentar efeitos magnetoelétricos. Neste trabalho um estudo estrutural do composto (alfa-Fe2O30,25(alfa-Al2O 30,75 submetido à moagem em altas energias e tratamento térmico pós-moagem é apresentado. As amostras foram caracterizadas por difração de raios X, refinamento estrutural Rietveld e espectroscopia Mössbauer. A determinação e identificação das fases cristalográficas, parâmetros de rede e volume de celas unitárias nas amostras moída e tratada termicamente permitiu verificar as mudanças dos parâmetros, a formação de espinélios e possíveis deformações relativas advindas do processo de moagem em altas energias.Multiferroics are materials in which two or all three of the properties, ferroelectricity, ferromagnetism, and ferroelasticity occur in the same phase. In particular, multiferroic magnetoelectrics represent the materials that are simultaneously ferromagnetic and ferroelectric, with or without ferroelasticity. Specifically, the hematite (alpha-Fe2O3-alumina (alpha-Al2O3 system has been studied, mainly due to its potential applications in metallurgy and as catalyst of ammonia synthesis. However, compounds of this system also may present magnetoelectric effects. In this work, a structural study of the high-energy ball milled and annealed (alpha-Fe2O3 0.25(alpha-Al2O30.75 compound was carefully conducted. The samples were

  17. Use of an integrated modelling and simulation approach to develop a simplified peginterferon alfa-2a dosing regimen for children with hepatitis C.

    Science.gov (United States)

    Brennan, Barbara J; Lemenuel-Diot, Annabelle; Snoeck, Eric; McKenna, Michael; Solsky, Jonathan; Wat, Cynthia; Mallalieu, Navita L

    2016-04-01

    The aim of the study was to simplify the dosing regimen of peginterferon alfa-2a in paediatric patients with chronic hepatitis C. A population pharmacokinetic (PK) model was developed using PK data from 14 children aged 2-8 years and 402 adults. Simulations were produced to identify a simplified dosing regimen that would provide exposures similar to those observed in the paediatric clinical trials and in the range known to be safe/efficacious in adults. Model predictions were evaluated against observed adult and paediatric data to reinforce confidence of the proposed dosing regimen. The final model was a two compartment model with a zero order resorption process. Covariates included a linear influence of body surface area (BSA) on apparent oral clearance (CL/F) and a linear influence of body weight on apparent volume of distribution of the central compartment (V1 /F). A simplified dosing regimen was developed which is expected to provide exposures in children aged ≥5 years similar to the dosing formula used in the paediatric clinical trial and within the range that is safe/efficacious in adults. This simplified regimen is approved in the EU and in other countries for the treatment of chronic hepatitis C in treatment-naive children/adolescents aged ≥5 years in combination with ribavirin. Pre-existing adult PK data were combined with relatively limited paediatric PK data to develop a PK model able to predict exposure in both populations adequately. This provided increased confidence in characterizing PK in children and helped in the development of a simplified dosing regimen of peginterferon alfa-2a in paediatric patients. © 2015 The British Pharmacological Society.

  18. Hypofractionation for radiotherapy of prostate cancer using a low alfa/beta ratio - possible reasons for concerns? An example of five dimensional radiotherapy

    International Nuclear Information System (INIS)

    Lennernaes, Bo; Nilsson, Sten; Levitt, Seymour

    2011-01-01

    It is very attractive, due to the assumed low alfa/beta ratio of prostate cancer (PC), to construct new treatment schedules for prostate cancer using only a few large fractions of radiation (hypofractionation). This will widen the therapeutic window since the ratio for PC might be lower than that of the organs at risk (OAR). PC is an extremely variable disease and often contains both highly and poorly differentiated cells. It is reasonable to assume that different cells have different patterns of radiosensitivity, i.e. alfa/beta ratios and proliferation. In this study we will simulate the effect on the outcome of the treatment with different fractionations and different ratios. Material and methods. In this simulation we use an extension of the Linear Quadratic (LQ)/Biological Effective Dose (BED) formula called the dose volume inhomogeneity corrected BED (DVIC-BED). In the formula the tumour volume is divided in 50 subvolumes (step of 2%) and it is possible to calculate the relative effect of the treatment with different ratios (1.5, 4 and 6.5) in different subvolumes. Results. The simulations demonstrate that only a small portion (5-10%) of cells with a higher ratio will dramatically change the effect of the treatment. Increasing the total dose can compensate this, but this will on the other hand increase the dose to the OAR and also the risk for severe side effects. Conclusion. These simulations highlight possible reasons for concerns about the use of hypofractionation for pathologically heterogeneous tumours, such as prostate cancer, and also demonstrate the need for testing new treatment schedules using both high and low ratios

  19. Multicenter, noninterventional, post-marketing surveillance study to evaluate dosing of recombinant human follicle-stimulating hormone using the redesigned follitropin alfa pen in women undergoing ovulation induction

    Science.gov (United States)

    Nawroth, Frank; Tandler-Schneider, Andreas; Bilger, Wilma

    2015-01-01

    This prospective, noninterventional, post-marketing surveillance study evaluated doses of recombinant human follicle-stimulating hormone (r-hFSH) using the redesigned follitropin alfa pen in women who were anovulatory or oligomenorrheic and undergoing ovulation induction (OI) alone or OI with intrauterine insemination. The primary endpoint was the proportion of patients who achieved monofollicular or bifollicular development (defined as one or two follicles ≥15 mm). Secondary endpoints included characteristics of ovulation stimulation treatment, such as mean total and mean daily r-hFSH doses. Data were analyzed for 3,193 patients from 30 German fertility centers. The proportion of patients with monofollicular or bifollicular development was 71.1% (n=2,270 of a total of 3,193 patients; intent-to-treat population). The mean±standard deviation total and daily doses of r-hFSH were 696.9±542.5 IU and 61.7±29.4 IU, respectively. The three doses prescribed most frequently were: 37.5 IU (n=703 from N=3,189; 22.0%), 50.0 IU (n=1,056 from N=3,189; 33.1%), and 75.0 IU (n=738 from N=3,189; 23.1%) on the first day of stimulation; and 37.5 IU (n=465 from N=3,189; 14.6%), 50.0 IU (n=922 from N=3,189; 28.9%), and 75.0 IU (n=895 from N=3,189; 28.1%) on the last day of stimulation. This noninterventional, post-marketing surveillance study found that monofollicular or bifollicular development was achieved in 71% of patients studied and the small dose increment (12.5 IU) of the redesigned follitropin alfa pen allowed individualized treatment of women undergoing OI. PMID:25926755

  20. Ovarian response to 150 µg corifollitropin alfa in a GnRH-antagonist multiple-dose protocol: a prospective cohort study.

    Science.gov (United States)

    Lerman, Tamara; Depenbusch, Marion; Schultze-Mosgau, Askan; von Otte, Soeren; Scheinhardt, Markus; Koenig, Inke; Kamischke, Axel; Macek, Milan; Schwennicke, Arne; Segerer, Sabine; Griesinger, Georg

    2017-05-01

    The incidence of low (18 oocytes) ovarian response to 150 µg corifollitropin alfa in relation to anti-Müllerian hormone (AMH) and other biomarkers was studied in a multi-centre (n = 5), multi-national, prospective, investigator-initiated, observational cohort study. Infertile women (n = 212), body weight >60 kg, underwent controlled ovarian stimulation in a gonadotrophin-releasing hormone-antagonist multiple-dose protocol. Demographic, sonographic and endocrine parameters were prospectively assessed on cycle day 2 or 3 of a spontaneous menstruation before the administration of 150 µg corifollitropin alfa. Serum AMH showed the best correlation with the number of oocytes obtained among all predictor variables. In receiver-operating characteristic analysis, AMH at a threshold of 0.91 ng/ml showed a sensitivity of 82.4%, specificity of 82.4%, positive predictive value 52.9%and negative predictive value 95.1% for predicting low response (area under the curve [AUC], 95% CI; P-value: 0.853, 0.769-0.936; <0.0001). For predicting high response, the optimal threshold for AMH was 2.58 ng/ml, relating to a sensitivity of 80.0%, specificity 82.1%, positive predictive value 42.5% and negative predictive value 96.1% (AUC, 95% CI; P-value: 0.871, 0.787-0.955; <0.0001). In conclusion, patients with serum AMH concentrations between approximately 0.9 and 2.6 ng/ml were unlikely to show extremes of response. Copyright © 2017. Published by Elsevier Ltd.

  1. Low-Latitude Solar Wind During the Fall 1998 SOHO-Ulysses Quadrature

    Science.gov (United States)

    Poletto, G.; Suess, S. T.; Biesecker, D. A.; Esser, R.; Gloeckler, G.; Ko, Y.-K.; Zurbuchen, T. H.

    2002-01-01

    Solar and Heliospheric Observatory (SOH0)-Ulysses quadratures occur when the SOHO-Sun-Ulysses-included angle is 90 deg. These offer the opportunity to directly compare properties of plasma parcels, observed by SOHO [Dorningo et al.] in the low corona, with properties of the same parcels measured, in due time, in situ, by Ulysses [ Wenzel et al]. We refer the reader to Suess et al. for an extended discussion of SOHO-Ulysses quadrature geometry. Here it suffices to recall that there are two quadratures per year, as SOHO makes its one-year revolution around the Sun. This, because SOHO is at the L1 Lagrangian point, in essentially the same place as the Earth, while Ulysses is in a near-polar -5-year solar orbit with a perihelion of 1.34 AU and aphelion of 5.4 AU.

  2. Momentum flux associated with gravity waves in the low-latitude troposphere

    Directory of Open Access Journals (Sweden)

    S. R. Prabhakaran Nayar

    Full Text Available The vertical fluxes of horizontal momentum at tropospheric heights are calculated for four days, 25–28 August 1999. The mean zonal wind during these days show the presence of strong westward wind at the upper troposphere. Both the symmetric beam radar method and the power spectral method of evaluation of vertical flux of zonal and meridional momentum shows nearly the same result for quiet conditions. The temporal evolution of the momentum flux is estimated for a day with strong zonal shear and convection. These results indicate that on 28 August 1999, the strong downward vertical wind in the lower altitude range is associated with upward vertical flux of zonal momentum, and strong upward vertical wind is associated with downward vertical flux. Similarly, the strong shear in zonal wind is associated with the increase in negative values in vertical flux in the upper troposphere. Analysis of the role of wave periods in the transport of momentum flux indicates that the vertical momentum flux magnitude is not evenly distributed in all wave periods, but instead it peaks at certain wave periods in the range 10 to 100 min.

    Key words. Meteorology and atmospheric dynamics (convective process; tropical meteorology; precipitation

  3. Low-Latitude Ionosphere and Thermosphere: Decadal Observations From the CHAMP Mission

    DEFF Research Database (Denmark)

    Stolle, Claudia; Liu, Huixin

    2014-01-01

    Self-consistent physical models of an auroral flux tube are capable of calculating optical emissions and ionospheric state variables for a given set of magnetospheric drivers. The collocation of incoherent scatter radar (ISR) and photometric measurements provides a powerful framework for testing ...

  4. Understanding Late Triassic low latitude terrestrial ecosystems: new insights from the Colorado Plateau Coring Project (CPCP)

    Science.gov (United States)

    Irmis, R. B.; Olsen, P. E.; Parker, W.; Rasmussen, C.; Mundil, R.; Whiteside, J. H.

    2017-12-01

    The Chinle Formation of southwestern North America is a key paleontological archive of low paleolatitude non-marine ecosystems that existed during the Late Triassic hothouse world. These strata were deposited at 5-15°N latitude, and preserve extensive plant, invertebrate, and vertebrate fossil assemblages, including early dinosaurs; these organisms lived in an unpredictably fluctuating semi-arid to arid environment with very high atmospheric pCO2. Despite this well-studied fossil record, a full understanding of these ecosystems and their integration with other fossil assemblages globally has been hindered by a poor understanding of the Chinle Formation's age, duration, and sedimentation rates. Recently, the CPCP recovered a 520m continuous core through this formation from the northern portion of Petrified Forest National Park (PEFO) in northern Arizona, USA. This core has provided a plethora of new radioisotopic and magnetostratigraphic data from fresh, unweathered samples in unambiguous stratigraphic superposition. These constraints confirm that virtually all fossil-bearing horizons in Chinle outcrops in the vicinity of PEFO are Norian in age. Furthermore, they indicate that the palynomorph zone II and Adamanian vertebrate biozone are at least six million years long, whereas the overlying palynomorph zone III and Revueltian vertebrate biozone persisted for at least five million years, with the boundary between 216-214 Ma. This confirms that the rich late Adamanian-early Revueltian vertebrate fossil assemblages, where dinosaurs are exclusively rare, small-bodied carnivorous theropods, are contemporaneous with higher latitude assemblages in Europe, South America, and Africa where large-bodied herbivorous sauropodomorph dinosaurs are common. The age constraints also confirm that several palynomorph biostratigraphic ranges in the Chinle Formation differ from those of the same taxa in eastern North American (Newark Supergroup) and Europe. These data are consistent with the hypothesis that latitudinal differences in climate sorted the biota found across Pangaea during the Late Triassic Period.

  5. VLF/LF (Very Low Frequency/Low Frequency) Reflection Properties of the Low Latitude Ionosphere

    Science.gov (United States)

    1988-02-04

    pleasure for the U.S. personnel. Although it is virtually impossible to mention all the individuals who contributed, we wish to especially ... Educacional da Regiao de Blumenau (FURB), who planned the day-to-day experimental efforts and who provided valuable technical Insight and guidance to all...or more grazing incidence angle, with the trend being especially pronounced in the daytime. Figure 23 shows 20 kHz reflectiont coefficients derived

  6. Spectral features of lightning-induced ion cyclotron waves at low latitudes: DEMETER observations and simulation

    Czech Academy of Sciences Publication Activity Database

    Shklyar, D. R.; Storey, L. R. O.; Chum, Jaroslav; Jiříček, František; Němec, F.; Parrot, M.; Santolík, Ondřej; Titova, E. E.

    2012-01-01

    Roč. 117, A12 (2012), A12206/1-A12206/16 ISSN 0148-0227 R&D Projects: GA ČR GA205/09/1253; GA ČR GAP205/10/2279; GA MŠk ME09107 Grant - others:GA ČR(CZ) GPP209/12/P658 Program:GP Institutional support: RVO:68378289 Keywords : Plasma waves analysis * ion cyclotron waves * satellite observation and numerical simulation * geometrical optics * multi-component measurements * simulation * spectrogram * wave propagation Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 3.174, year: 2012 http://onlinelibrary.wiley.com/doi/10.1029/2012JA018016/abstract

  7. Late Jurassic low latitude of Central Iran: paleogeographic and tectonic implications

    Science.gov (United States)

    Mattei, Massimo; Muttoni, Giovanni; Cifelli, Francesca

    2014-05-01

    The individual blocks forming present-day Central Iran are now comprised between the Zagros Neo-Tethys suture to the south and the Alborz Palaeo-Tethys suture to the north. At the end of the Palaeozoic, the Iranian blocks rifted away from the northern margin of Gondwana as consequence of the opening of the Neo-Tethys, and collided with Eurasia during the Late Triassic, giving place to the Eo-Cimmerian orogeny. From then on, the Iranian block(s) should have maintained European affinity. Modern generations of apparent polar wander paths (APWPs) show the occurrence in North American and African coordinates of a major and rapid shift in pole position (=plate shift) during the Middle-Late Jurassic. This so-called monster polar shift is predicted also for Eurasia from the North Atlantic plate circuit, but Jurassic data from this continent are scanty and problematic. Here, we present paleomagnetic data from the Kimmeridgian-Tithonian (Upper Jurassic) Garedu Formation of Iran. Paleomagnetic component directions of primary (pre-folding) age indicate a paleolatitude of deposition of 10°N ± 5° that is in excellent agreement with the latitude drop predicted for Iran from APWPs incorporating the Jurassic monster polar shift. We show that paleolatitudes calculated from these APWPs, used in conjunction with simple zonal climate belts, better explain the overall stratigraphic evolution of Iran during the Mesozoic.

  8. Electrodynamic coupling of high and low latitudes: Observations on May 27, 1993

    DEFF Research Database (Denmark)

    Kobea, A.T.; Richmond, A.D.; Emery, B.A.

    2000-01-01

    The penetration of disturbance electric fields from the polar region to the magnetic equator on the dayside of the Earth is examined with geomagnetic data on May 27, 1993. First, we examine a dayside equatorial disturbance that followed the rapid recovery of magnetic activity from a storm...... than 1 min for fluctuations having periods like those examined here. A synoptic inversion analysis of the high-latitude magnetic data to estimate the time-varying high-latitude electric potential patterns shows that fluctuations of the high-latitude east-west potential gradient tended...

  9. Letter to the Editor: Geomagnetic storm effects at low latitudes

    OpenAIRE

    R. G. Rastogi; R. G. Rastogi

    1999-01-01

    The geomagnetic horizontal (H) field from the chain of nine observatories in India are used to study the storm-time and disturbance daily variations. The peak decrease in storm-time variation in H showed significant enhancements at the equatorial electrojet stations over and above the normally expected decrease due to the ring current effects corrected for geomagnetic latitudes. The disturbance daily variation of H at equatorial stations showed a large decrease around midday...

  10. Event sedimentation in low-latitude deep-water carbonate basins, Anegada passage, northeast Caribbean

    Science.gov (United States)

    Chaytor, Jason D.; ten Brink, Uri S.

    2015-01-01

    The Virgin Islands and Whiting basins in the Northeast Caribbean are deep, structurally controlled depocentres partially bound by shallow-water carbonate platforms. Closed basins such as these are thought to document earthquake and hurricane events through the accumulation of event layers such as debris flow and turbidity current deposits and the internal deformation of deposited material. Event layers in the Virgin Islands and Whiting basins are predominantly thin and discontinuous, containing varying amounts of reef- and slope-derived material. Three turbidites/sandy intervals in the upper 2 m of sediment in the eastern Virgin Islands Basin were deposited between ca. 2000 and 13 600 years ago, but do not extend across the basin. In the central and western Virgin Islands Basin, a structureless clay-rich interval is interpreted to be a unifite. Within the Whiting Basin, several discontinuous turbidites and other sand-rich intervals are primarily deposited in base of slope fans. The youngest of these turbidites is ca. 2600 years old. Sediment accumulation in these basins is low (−1) for basin adjacent to carbonate platform, possibly due to limited sediment input during highstand sea-level conditions, sediment trapping and/or cohesive basin walls. We find no evidence of recent sediment transport (turbidites or debris flows) or sediment deformation that can be attributed to the ca. M7.2 1867 Virgin Islands earthquake whose epicentre was located on the north wall of the Virgin Islands Basin or to recent hurricanes that have impacted the region. The lack of significant appreciable pebble or greater size carbonate material in any of the available cores suggests that submarine landslide and basin-wide blocky debris flows have not been a significant mechanism of basin margin modification in the last several thousand years. Thus, basins such as those described here may be poor recorders of past natural hazards, but may provide a long-term record of past oceanographic conditions in ocean passages.

  11. Low latitude ionospheric TEC responses to dynamical complexity quantifiers during transient events over Nigeria

    Science.gov (United States)

    Ogunsua, Babalola

    2018-04-01

    In this study, the values of chaoticity and dynamical complexity parameters for some selected storm periods in the year 2011 and 2012 have been computed. This was done using detrended TEC data sets measured from Birnin-Kebbi, Torro and Enugu global positioning system (GPS) receiver stations in Nigeria. It was observed that the significance of difference (SD) values were mostly greater than 1.96 but surprisingly lower than 1.96 in September 29, 2011. The values of the computed SD were also found to be reduced in most cases just after the geomagnetic storm with immediate recovery a day after the main phase of the storm while the values of Lyapunov exponent and Tsallis entropy remains reduced due to the influence of geomagnetic storms. It was also observed that the value of Lyapunov exponent and Tsallis entropy reveals similar variation pattern during storm period in most cases. Also recorded surprisingly were lower values of these dynamical quantifiers during the solar flare event of August 8th and 9th of the year 2011. The possible mechanisms responsible for these observations were further discussed in this work. However, our observations show that the ionospheric effects of some other possible transient events other than geomagnetic storms can also be revealed by the variation of chaoticity and dynamical complexity.

  12. CYGNSS Surface Wind Observations and Surface Flux Estimates within Low-Latitude Extratropical Cyclones

    Science.gov (United States)

    Crespo, J.; Posselt, D. J.

    2017-12-01

    The Cyclone Global Navigation Satellite System (CYGNSS), launched in December 2016, aims to improve estimates of surface wind speeds over the tropical oceans. While CYGNSS's core mission is to provide better estimates of surface winds within the core of tropical cyclones, previous research has shown that the constellation, with its orbital inclination of 35°, also has the ability to observe numerous extratropical cyclones that form in the lower latitudes. Along with its high spatial and temporal resolution, CYGNSS can provide new insights into how extratropical cyclones develop and evolve, especially in the presence of thick clouds and precipitation. We will demonstrate this by presenting case studies of multiple extratropical cyclones observed by CYGNSS early on in its mission in both Northern and Southern Hemispheres. By using the improved estimates of surface wind speeds from CYGNSS, we can obtain better estimates of surface latent and sensible heat fluxes within and around extratropical cyclones. Surface heat fluxes, driven by surface winds and strong vertical gradients of water vapor and temperature, play a key role in marine cyclogenesis as they increase instability within the boundary layer and may contribute to extreme marine cyclogenesis. In the past, it has been difficult to estimate surface heat fluxes from space borne instruments, as these fluxes cannot be observed directly from space, and deficiencies in spatial coverage and attenuation from clouds and precipitation lead to inaccurate estimates of surface flux components, such as surface wind speeds. While CYGNSS only contributes estimates of surface wind speeds, we can combine this data with other reanalysis and satellite data to provide improved estimates of surface sensible and latent heat fluxes within and around extratropical cyclones and throughout the entire CYGNSS mission.

  13. Higher predation risk for insect prey at low latitudes and elevations

    Czech Academy of Sciences Publication Activity Database

    Roslin, T.; Hardwick, B.; Novotný, Vojtěch; Petry, W. K.; Andrew, N. R.; Asmus, A.; Barrio, I. C.; Basset, Yves; Boesing, A. L.; Bonebrake, T. C.; Cameron, E. K.; Dáttilo, W.; Donoso, D. A.; Drozd, P.; Gray, C. L.; Hik, S. D.; Hill, S. J.; Hopkins, T.; Huang, S.; Koane, B.; Laird-Hopkins, B.; Laukkanen, L.; Lewis, O. T.; Milne, S.; Mwesige, I.; Nakamura, A.; Nell, C. S.; Nichols, E.; Prokurat, A.; Sam, Kateřina; Schmidt, N. M.; Slade, A.; Slade, V.; Suchánková, A.; Teder, T.; van Nouhuys, S.; Vandvik, V.; Weissflog, A.; Zhukovich, V.; Slade, E. M.

    2017-01-01

    Roč. 356, č. 6339 (2017), s. 742-744 ISSN 0036-8075 R&D Projects: GA ČR(CZ) GP14-32024P; GA ČR(CZ) GA14-04258S EU Projects: European Commission(XE) 669609 - Diversity6continents Institutional support: RVO:60077344 Keywords : plasticine caterpillars * arthropod predation * bird predation Subject RIV: EH - Ecology, Behaviour OBOR OECD: Ecology Impact factor: 37.205, year: 2016 http:// science . science mag.org/content/356/6339/742/tab-pdf

  14. The influence of low latitude forcing on European Ice sheet dynamics

    Science.gov (United States)

    Kaboth, Stefanie; Bahr, André; Lourens, Lucas J.

    2017-04-01

    Distinct mid-glacial δ18O enrichment events found at Site U1386 in the Gulf of Cadiz during Marine Isotope Stages 6 and 8 represent a striking feature absent in most deep-sea benthic δ18O records studied worldwide. These δ18O enrichment events are closely related to periods of maximum precession and aligned with previous findings from the Mediterranean and Red Seas. Here we present paired planktic and benthic stable isotope (δ18O and δ13C) and Mg/Ca-based temperature records of Site U1386 of the last 300.000 years. Our results show that these δ18O enrichment events are recorded in both subsurface and bottom water masses and pre-date the largest cooling events along the Iberian Margin and associated European sourced meltwater pulses of the Drenthe and Fuhne major ice-sheet advances, suggesting that they instead correspond to periods of maximum ice volume extend in Europe.

  15. Characteristics of low-latitude ionospheric depletions and enhancements during solar minimum

    Science.gov (United States)

    Haaser, R. A.; Earle, G. D.; Heelis, R. A.; Klenzing, J.; Stoneback, R.; Coley, W. R.; Burrell, A. G.

    2012-10-01

    Under the waning solar minimum conditions during 2009 and 2010, the Ion Velocity Meter, part of the Coupled Ion Neutral Dynamics Investigation aboard the Communication/Navigation Outage Forecasting System satellite, is used to measure in situ nighttime ion densities and drifts at altitudes between 400 and 550 km during the hours 21:00-03:00 solar local time. A new approach to detecting and classifying well-formed ionospheric plasma depletions and enhancements (bubbles and blobs) with scale sizes between 50 and 500 km is used to develop geophysical statistics for the summer, winter, and equinox seasons during the quiet solar conditions. Some diurnal and seasonal geomagnetic distribution characteristics confirm previous work on equatorial irregularities and scintillations, while other elements reveal new behaviors that will require further investigation before they may be fully understood. Events identified in the study reveal very different and often opposite behaviors of bubbles and blobs during solar minimum. In particular, more bubbles demonstrating deeper density fluctuations and faster perturbation plasma drifts typically occur earlier near the magnetic equator, while blobs of similar magnitude occur more often far away from the geomagnetic equator closer to midnight.

  16. Why Do Model Tropical Cyclones Intensify More Rapidly at Low Latitudes?

    Science.gov (United States)

    2015-05-01

    University of Munich, Munich, Germany MICHAEL T. MONTGOMERY Department of Meteorology, Naval Postgraduate School , Monterey, California (Manuscript...WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School ,Department of Meteorology,Monterey,CA,93943 8...Roy.Meteor. Soc., 135, 839–850, doi:10.1002/qj.390. Willoughby, H. E., 1979: Forced secondary circulations in hurri- canes . J. Geophys. Res., 84, 3173

  17. Energetic particles and ionization in the nighttime middle and low latitude ionosphere

    International Nuclear Information System (INIS)

    Voss, H.D.; Smith, L.G.

    1977-01-01

    Seven Nike Apache rockets, each equipped with an energetic particle spectrometer (12 E 80 keV) and electron-density experiments, were launched from Wallops Island, Virginia and Chilca, Peru, under varying geomagnetic conditions near midnight. At Wallops Island the energetic particle flux (E 40 keV) is found to be strongly dependent on Kp. The pitch-angle distribution is asymmetrical about a peak at 90 D signifying a predominately quasi-trapped flux and explaining the linear increase of count rate with altitute in the altitude region 120 to 200 km. The height-averaged ionization rates derived from the electron-density profiles are consistent with the rates calculated from the observed total particle flux for magnetic index Kp 3. In the region 90 to 110 km it is found that the nighttime ionization is primarily a result of Ly-beta radiation from the geocorona and interplanetary hydrogen for even very disturbed conditions. Below 90 km during rather disturbed conditions energetic electrons can be a significant ionization source. Two energetic particle precipitation zones have been identified at midlatitudes

  18. Lunar Tidal Effects in the Electrodynamics of the Low-Latitude Ionosphere

    OpenAIRE

    Tracy, Brian David

    2013-01-01

    We used extensive measurements made by the Jicamarca Unattended Long-Term Investigations of the Ionosphere and Atmosphere (JULIA) and Incoherent Scatter Radar (ISR) systems at Jicamarca, Peru during geomagnetic quiet conditions to determine the climatologies of lunar tidal effects on equatorial vertical plasma drifts. We use, for the first time, the expectation maximization (EM) algorithm to derive the amplitudes and phases of the semimonthly and monthly lunar tidal perturbations. Our result...

  19. Multipoint Observations of Low Latitude ULF Pc3 Waves in South ...

    Indian Academy of Sciences (India)

    pulsations are quasi-sinusoidal variations in the earth's magnetic field in the period range 10–45 seconds. The magnitude of these pulsations ranges from fraction of a nT (nano Tesla) to several nT. These pulsations can be observed in a number of ways. However, the application of ground-based magnetometer arrays has ...

  20. Energetic particles and ionization in the nighttime middle and low latitude ionosphere

    Science.gov (United States)

    Voss, H. D.; Smith, L. G.

    1977-01-01

    Seven Nike Apache rockets, each equipped with an energetic particle spectrometer (12 E 80 keV) and electron-density experiments, were launched from Wallops Island, Virginia and Chilca, Peru, under varying geomagnetic conditions near midnight. At Wallops Island the energetic particle flux (E 40 keV) is found to be strongly dependent on Kp. The pitch-angle distribution is asymmetrical about a peak at 90 D signifying a predominately quasi-trapped flux and explaining the linear increase of count rate with altitute in the altitude region 120 to 200 km. The height-averaged ionization rates derived from the electron-density profiles are consistent with the rates calculated from the observed total particle flux for magnetic index Kp 3. In the region 90 to 110 km it is found that the nighttime ionization is primarily a result of Ly-beta radiation from the geocorona and interplanetary hydrogen for even very disturbed conditions. Below 90 km during rather disturbed conditions energetic electrons can be a significant ionization source. Two energetic particle precipitation zones have been identified at midlatitudes.

  1. Low latitude ionosphere-thermosphere dynamics studies with inosonde chain in Southeast Asia

    Directory of Open Access Journals (Sweden)

    T. Maruyama

    2007-07-01

    Full Text Available An ionosonde network consisting of a meridional chain and an equatorial pair was established in the Southeast Asian area. Three of four ionosondes are along the magnetic meridian of 100° E; two are close to the magnetic conjugate points in Northern Thailand and West Sumatra, Indonesia, and the other is near the magnetic equator in the Malay Peninsula, Thailand. The fourth ionosonde is also near the magnetic equator in Vietnam but separated by about 6.3° towards east from the meridional chain. For a preliminary data analysis, nighttime ionospheric height variations at the three stations of the meridional chain were examined. The results demonstrate that the coordination of the network has a great potential for studying ionosphere/thermosphere dynamics. Through the assistance of model calculations, thermospheric neutral winds were inferred and compared with the HWM93 empirical thermospheric wind model. Higher-order wind variations that are not represented in the empirical model were found.

  2. Effect of pods' position on the protein content in soybean grains at low latitude

    Directory of Open Access Journals (Sweden)

    Paulo Victor Gomes Sales

    2016-12-01

    Full Text Available Soybean grains have a high protein content, which can vary depending on various factors, as the pods' position throughout the plant. In this sense, aiming to study the effect of pods' position on the main stem of the plant for grades of soybean proteins, It has been accomplished in the years 2010 and 2011, a trial with ten soybean cultivars in the experimental area of the Federal University of Tocantins in Palmas. The experimental area was randomized blocks with 30 treatments and three replications. Treatments were arranged in one a split plot, being allocated in Ten cultivars plots (BRS Valuable, P98Y51, P98Y70, P99R03, M8527RR, M8925RR, M9144RR, M8867RR, and TMG103RR, and the sub plots In the pods' position on the plant (upper third, intermediate, and basal third. According to the results, we can conclude that there is variability among the pods' position. The grains located in the median and apical plant showed a trend of higher protein content. Cultivar P98Y70 showed the highest protein value. In the sampling grain for protein quantitation, it is recommended to use grains of pods located at the same position of the plant.

  3. The air-sea exchange of mercury in the low latitude Pacific and Atlantic Oceans

    Science.gov (United States)

    Mason, Robert P.; Hammerschmidt, Chad R.; Lamborg, Carl H.; Bowman, Katlin L.; Swarr, Gretchen J.; Shelley, Rachel U.

    2017-04-01

    Air-sea exchange is an important component of the global mercury (Hg) cycle as it mediates the rate of increase in ocean Hg, and therefore the rate of change in levels of methylmercury (MeHg), the most toxic and bioaccumulative form of Hg in seafood and the driver of human health concerns. Gas evasion of elemental Hg (Hg0) from the ocean is an important sink for ocean Hg with previous studies suggesting that evasion is not uniform across ocean basins. To understand further the factors controlling Hg0 evasion, and its relationship to atmospheric Hg deposition, we made measurements of dissolved Hg0 (DHg0) in surface waters, along with measurements of Hg in precipitation and on aerosols, and Hg0 in marine air, during two GEOTRACES cruises; GP16 in the equatorial South Pacific and GA03 in the North Atlantic. We contrast the concentrations and estimated evasion fluxes of Hg0 during these cruises, and the factors influencing this exchange. Concentrations of DHg0 and fluxes were lower during the GP16 cruise than during the GA03 cruise, and likely reflect the lower atmospheric deposition in the South Pacific. An examination of Hg/Al ratios for aerosols from the cruises suggests that they were anthropogenically-enriched relative to crustal material, although to a lesser degree for the South Pacific than the aerosols over the North Atlantic. Both regions appear to be net sources of Hg0 to the atmosphere (evasion>deposition) and the reasons for this are discussed. Overall, the studies reported here provide further clarification on the factors controlling evasion of Hg0 from the ocean surface, and the role of anthropogenic inputs in influencing ocean Hg concentrations.

  4. Geomagnetically conjugate observation of plasma bubbles and thermospheric neutral winds at low latitudes

    Science.gov (United States)

    Fukushima, D.; Shiokawa, K.; Otsuka, Y.; Nishioka, M.; Kubota, M.; Tsugawa, T.; Nagatsuma, T.; Komonjinda, S.; Yatini, C. Y.

    2015-03-01

    This is the first paper that reports simultaneous observations of zonal drift of plasma bubbles and the thermospheric neutral winds at geomagnetically conjugate points in both hemispheres. The plasma bubbles were observed in the 630 nm nighttime airglow images taken by using highly sensitive all-sky airglow imagers at Kototabang, Indonesia (geomagnetic latitude (MLAT): 10.0°S), and Chiang Mai, Thailand (MLAT: 8.9°N), which are nearly geomagnetically conjugate stations, for 7 h from 13 to 20 UT (from 20 to 03 LT) on 5 April 2011. The bubbles continuously propagated eastward with velocities of 100-125 m/s. The 630 nm images at Chiang Mai and those mapped to the conjugate point of Kototabang fit very well, which indicates that the observed plasma bubbles were geomagnetically connected. The eastward thermospheric neutral winds measured by two Fabry-Perot interferometers were 70-130 m/s at Kototabang and 50-90 m/s at Chiang Mai. We compared the observed plasma bubble drift velocity with the velocity calculated from the observed neutral winds and the model conductivity, to investigate the F region dynamo contribution to the bubble drift velocity. The estimated drift velocities were 60-90% of the observed velocities of the plasma bubbles, suggesting that most of the plasma bubble velocity can be explained by the F region dynamo effect.

  5. Temporal and Spatial Characterization of GPS Fading From Ionospheric Irregularities Under Low latitude

    Science.gov (United States)

    De Paula, E. R.; Moraes, A. D. O.; Vani, B. C.; Sobral, J. H. A.; Abdu, M. A.; Galera Monico, J. F.

    2017-12-01

    The ionosphere over the peak of the anomaly represents a treat for navigation systems based on GNSS. Brazilian territory is mostly under this harsh layer for satellite communication in general and in particular for navigation, like GPS users, where their receivers tracking performance are damaged under scintillation conditions. Ionospheric scintillation is responsible for significant degradation in the accuracy of navigation and positioning. Phase shifts accompanied by amplitude fades significantly degrades the signal-to-noise ratio of the received signal disrupting the channel and loosing navigation performance. The stronger the scintillations are, more difficulty will be for the GNSS receiver tracking loops to recover the phase and code replicas. These phenomena under specific geophysical conditions may severely affect the system availability and positioning. In this work the temporal characteristics of amplitude scintillation will be analyzed at the three available GPS frequencies, L1, L2C and L5. Aspect like fading duration and depth will be evaluated and compared among the three available frequencies for the current solar cycle. This work will use GPS scintillation data recorded during six months of data during 2014 to 2015 at three stations under Brazilian territory located near the southern crest of the equatorial ionization anomaly. The analysis will be performed focusing on the fading profile of the three frequencies comparing how the fading of those signals behave statistically between them. Aspects like loss of lock, spatial orientation between the signal across the ionospheric irregularity will also be discussed showing how much more susceptible the new frequencies might be in comparison to the widely used and studied L1 frequency.

  6. Low Latitude Pelagic Foraminifera Found in the Hudson River: Are They Hurricane Deposits?

    Science.gov (United States)

    Monahan, K. M.; Abbott, D. H.; Hoenisch, B.; Breger, D.

    2011-12-01

    River sediment cores provide a record of past environmental changes through stacked layers of sediments. In core CD02-29A, recovered from the southern Hudson River, a significant number of tropical planktic foraminifer tests were found. Foraminifera were concentrated in sediment layers of low impedance, suggesting high carbonate content. Because modern planktic foraminifera are exclusively marine, their presence in Hudson sediments in the core was remarkable. We can think of only two mechanisms that could explain this observation: either living specimens are carried upriver with the daily tides, or storm surges carry large amounts of seawater and re-suspended marine sediment upriver. To test for the presence of living specimens in Hudson River water, plankton tow samples were collected during high tide at the Hudson Battery south of the sample site, and at Piermont Pier north of the sample site and no living foraminifera were found. In addition, oxygen isotope (δ18O) analyses reveal a marine composition but the large difference in δ18O between the two surface dwelling species Globigerinoides ruber (pink) and Globigerinoides sacculifer, picked from the same sediment layer, suggests re-suspension and mixing of marine sediment deposits. Because only planktic, tropical to subtropical foraminiferal assemblages were found, the Hudson River deposits differ from previously recorded storm deposits found on Long Island and in New Jersey. In particular, the foraminiferal assemblages contain up to 40% G. ruber (pink), suggesting a highly tropical signal from a location where abundances of G. ruber are very low. This data, in addition to the pulsed occurrence of tests in the sediment suggests that the introduction of planktic foraminifera into the Hudson River must be driven by rare events. We suggest that storm surges from rare high-intensity hurricanes most likely explain the presence of these tests in Hudson River sediments, possibly assisted by the Gulf Stream entraining tropical foraminifera in the temperate waters off New York. In this way low acoustic impedance levels which correlate well with foraminifer occurrence in our core could also correlate with deposition during past storm activity. Therefore, such simple analyses may provide indication of past storm activity in other sediment cores.

  7. Determination of the total cross section in proton-proton collisions at the LHC at √(s) = 8 TeV from elastic scattering using the ALFA sub-detector of ATLAS

    Energy Technology Data Exchange (ETDEWEB)

    Heinz, Christian; Dueren, Michael; Kreutzfeldt, Kristof; Stenzel, Hasko [JLU Giessen (Germany)

    2015-07-01

    The ALFA (Absolute Luminosity for ATLAS) Roman Pot detector system is part of the forward instrumentation of ATLAS located about 240 m away from the interaction point in the LHC tunnel. ALFA consists of a scintillating fibre tracker housed in vertical Roman Pots which enables the measurement of elastic proton-proton scattering at small scattering angles. In 2012 data were recorded at a centre-of-mass energy of √(s) = 8 TeV during a fill with special beam optics of the LHC with β* = 90 m and parallel-to-point focusing. The four-momentum transfer t is measured for elastically scattered protons and the differential elastic cross section is measured. In this talk a preliminary determination of the total cross section and of the slope of the elastic cross section at small vertical stroke t vertical stroke obtained from a fit to the differential cross section using the optical theorem is reported.

  8. Measurement of the proton-proton total cross section at √(s) = 7 TeV via elastic scattering with the ALFA sub-detector of ATLAS at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Kreutzfeldt, Kristof; Dueren, Michael; Heinz, Christian; Stenzel, Hasko [2. Physikalisches Institut, Universitaet Giessen (Germany)

    2015-07-01

    The ALFA (Absolute Luminosity for ATLAS) detector is one of the ATLAS forward detectors located about 240 m away from the interaction point in the LHC tunnel. ALFA is a scintillating fibre tracking detector housed in Roman pots and designed to measure elastic proton-proton scattering up to the smallest scattering angles. In 2011 data were taken at a centre-of-mass energy of √(s) = 7 TeV during a special low intensity fill of LHC with high β* = 90 m beam optics. Results of the measurement of the differential elastic cross section dσ/dt, the total cross section σ{sub tot}, the nuclear slope B and other derived quantities are presented in this talk. In the analysis the luminosity determination, the fine tuning of beam optics parameters and a data-driven method to determine the reconstruction efficiency are emphasized.

  9. Coste-efectividad de drotrecogina alfa (activada en el tratamiento de la sepsis grave en España Cost-effectiveness of drotrecogin alpha [activated] in the treatment of severe sepsis in Spain

    Directory of Open Access Journals (Sweden)

    José A Sacristán

    2004-02-01

    Full Text Available Introducción: El ensayo clínico PROWESS ha demostrado que el tratamiento con drotrecogina alfa (activada en pacientes con sepsis grave se asocia a una reducción del riesgo absoluto de muerte en comparación con el tratamiento estándar. El objetivo del estudio fue evaluar el coste-efectividad de drotrecogina alfa (activada, frente a tratamiento estándar, en el tratamiento de la sepsis grave en España. Pacientes y métodos: Se elaboró un modelo de análisis de decisión en el que se compararon los costes hasta el alta hospitalaria y la eficacia a largo plazo de drotrecogina alfa (activada frente a tratamiento estándar de pacientes con sepsis grave en España, desde la perspectiva del financiador de los servicios sanitarios. La mayoría de la información para realizar el modelo se obtuvo del ensayo clínico PROWESS. El análisis basal fue doble: a para todos los pacientes incluidos en el ensayo clínico PROWESS, y b para los pacientes con 2 o más fallos orgánicos. Las variables principales de valoración clínica fueron la reducción de la mortalidad hospitalaria y los años de vida ganados (AVG. El coste-efectividad se expresó como coste por AVG. Se realizó un análisis de sensibilidad utilizando tasas de descuento del 3 y el 5% para los AVG y modificando los patrones de atención sanitaria, los costes de la unidad de cuidados intensivos, la esperanza de vida según la comorbilidad inicial y la eficacia terapéutica de drotrecogina alfa (activada. Resultados: El tratamiento con drotrecogina alfa (activada se asoció a un descenso del riesgo absoluto de mortalidad hospitalaria del 6,0% (p = 0,005 cuando se incluyeron todos los pacientes del estudio PROWESS, y una reducción del 7,3% (p = 0,005 cuando sólo se incluyeron los pacientes con 2 o más fracasos orgánicos. El coste-efectividad de drotrecogina alfa (activada fue de 13.550 euros por AVG respecto a placebo cuando se analizó el total de pacientes, y de 9.800 euros por AVG en el

  10. Reticulocyte dynamic and hemoglobin variability in hemodialysis patients treated with Darbepoetin alfa and C.E.R.A.: a randomized controlled trial.

    Science.gov (United States)

    Forni, Valentina; Bianchi, Giorgia; Ogna, Adam; Salvadé, Igor; Vuistiner, Philippe; Burnier, Michel; Gabutti, Luca

    2013-07-22

    In a simulation based on a pharmacokinetic model we demonstrated that increasing the erythropoiesis stimulating agents (ESAs) half-life or shortening their administration interval decreases hemoglobin variability. The benefit of reducing the administration interval was however lessened by the variability induced by more frequent dosage adjustments. The purpose of this study was to analyze the reticulocyte and hemoglobin kinetics and variability under different ESAs and administration intervals in a collective of chronic hemodialysis patients. The study was designed as an open-label, randomized, four-period cross-over investigation, including 30 patients under chronic hemodialysis at the regional hospital of Locarno (Switzerland) in February 2010 and lasting 2 years. Four subcutaneous treatment strategies (C.E.R.A. every 4 weeks Q4W and every 2 weeks Q2W, Darbepoetin alfa Q4W and Q2W) were compared with each other. The mean square successive difference of hemoglobin, reticulocyte count and ESAs dose was used to quantify variability. We distinguished a short- and a long-term variability based respectively on the weekly and monthly successive difference. No difference was found in the mean values of biological parameters (hemoglobin, reticulocytes, and ferritin) between the 4 strategies. ESAs type did not affect hemoglobin and reticulocyte variability, but C.E.R.A induced a more sustained reticulocytes response over time and increased the risk of hemoglobin overshooting (OR 2.7, p = 0.01). Shortening the administration interval lessened the amplitude of reticulocyte count fluctuations but resulted in more frequent ESAs dose adjustments and in amplified reticulocyte and hemoglobin variability. Q2W administration interval was however more favorable in terms of ESAs dose, allowing a 38% C.E.R.A. dose reduction, and no increase of Darbepoetin alfa. The reticulocyte dynamic was a more sensitive marker of time instability of the hemoglobin response under ESAs therapy

  11. Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study.

    Science.gov (United States)

    Poynard, Thierry; Bruix, Jordi; Schiff, Eugene R; Diago, Moises; Berg, Thomas; Moreno-Otero, Ricardo; Lyra, Andre C; Carrilho, Flair; Griffel, Louis H; Boparai, Navdeep; Jiang, Ruiyun; Burroughs, Margaret; Brass, Clifford A; Albrecht, Janice K

    2013-03-01

    Therapeutic options for patients failing hepatitis C retreatment are limited. EPIC(3) included a prospective trial assessing long-term peginterferon alfa-2b (PegIFNα-2b) maintenance therapy in patients with METAVIR fibrosis scores (MFS) of F2 or F3 who previously failed hepatitis C retreatment. Patients with F2/F3 MFS who failed retreatment were randomized to PegIFNα-2b (0.5 μg/kg/week, n=270) or observation (n=270) for 36 months. Blinded liver biopsies obtained before retreatment and after maintenance therapy were evaluated using MFS and activity scores, and confirmatory testing was performed using FibroTest and ActiTest. In total, 348 patients had paired biopsies: 192 patients had missing post-treatment biopsies and were considered as having no change in fibrosis/activity scores. In total, 16% of patients receiving PegIFNα-2b and 11% of observation patients had improvement in MFS (p=0.32). More PegIFNα-2b than observation patients had improvement in activity score (20% vs. 9%; p 2.5 years, improvement in MFS or activity score was more common with PegIFNα-2b than observation (21% vs. 14%, p=0.08 and 26% vs. 10%, p 2.5 years. Both FibroTest and ActiTest were significantly improved during maintenance therapy. Copyright © 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

  12. CLINICAL AND IMMUNOLOGICAL EFFICACY OF THE RECOMBINANT INTERFERON alfa-2b OF ACUTE EPSTEIN-BARR VIRAL MONONUCLEOSIS IN PRESCHOOL CHILDREN

    Directory of Open Access Journals (Sweden)

    V. N. Timchenko

    2016-01-01

    Full Text Available Conducted clinical and immunological examination of 51 children with acute Epstein-Barr viral mononucleosis (EBV in age from 1 year to 7 years. All children diagnosed with a moderate degree of the disease. In the treatment of 25 people (comparison group used the standard treatment (pathogenetic, symptomatic, treatment 26 people (main group included the use as antiviral and immunotropic means of the preparation of human recombinant interferon Alfa-2b in the form of rectal suppositories — VIFERON®. The immunological survey was conducted in dynamics: at the height of the disease and in the convalescence period. The blood was determined indicators of cellular immunity (leukocytes, lymphocytes, CD3+, CD4+, CD8+, CD56+, HLAII+, CD95+, CD1 6+, CD25+, the concentration of IFN-a, IFN-y, IL-4 levels in spontaneous and induced production, in the serum. At milestones children of the main group noted rapid regression of clinical symptoms, normalization of body temperature, reducing intoxication, positive dynamics lymphoproliferative syndrome, a significant reduction in bed-days, no layering respiratory viral infections. Interferon had also expressed a positive impact on the changed parameters of cellular immunity and cytokine links. At the same time, 80% of patients after basic treatment is established the predominance of Th2 type immune response, indicating a high risk of developing chronic course of EBV-mononucleosis.

  13. Análisis de consistencia interna mediante Alfa de Cronbach: un programa basado en gráficos dinámicos

    Directory of Open Access Journals (Sweden)

    Rubén Ledesma

    Full Text Available En este trabajo se presenta una herramienta informática original que permite realizar análisis de consistencia interna (modelo Alfa de Cronbach utilizando métodos gráficos dinámicos. Se trata de un módulo basado en la filosofía del Análisis Exploratorio de Datos y en métodos de visualización estadística, diseñado para asistir al analista en el proceso de construcción de pruebas psicológicas. La herramienta permite analizar la consistencia interna de la prueba, las propiedades de los ítems que la componen, los patrones de respuesta de los sujetos a los ítems, y el efecto de la eliminación de los ítems y del incremento en la longitud de la prueba sobre su fiabilidad. En comparación con otros programas existentes, el beneficio del módulo es la incorporación de gráficos estadísticos dinámicos como complemento a la presentación de resultados convencionales en formato texto.

  14. Treatment-naïve Gaucher disease patients achieve therapeutic goals and normalization with velaglucerase alfa by 4years in phase 3 trials.

    Science.gov (United States)

    Zimran, Ari; Elstein, Deborah; Gonzalez, Derlis E; Lukina, Elena A; Qin, Yulin; Dinh, Quinn; Turkia, Hadhami Ben

    2018-02-01

    Gaucher disease is an inherited metabolic disease characterized by β-glucocerebrosidase deficiency and commonly treated with enzyme replacement therapy (ERT). The efficacy of ERT with velaglucerase alfa was assessed based on the achievement of published therapeutic goals and the normalization of disease parameters in 39 treatment-naïve patients with type 1 Gaucher disease, 6 to 62years of age, enrolled in phase 3 clinical trials. After 4years of ERT, therapeutic goals for thrombocytopenia and splenomegaly had been achieved in 100% of patients; goals for anemia and hepatomegaly had been achieved in 95% and 94% of patients, respectively. Consistent with the goal for bone mineral density, lumbar spine bone density improved in 87% of patients ≥18years of age. At year 4, compared with clinical ranges for healthy individuals, 86% of patients with a low baseline hemoglobin concentration had normalized, 60% with a low baseline platelet count had normalized, 67% with baseline splenomegaly had normalized, 58% with hepatomegaly had normalized, and lumbar spine bone density had normalized in 53% of adults. The decade-old therapeutic goals do not reflect the potential for normalization of clinical parameters in ERT-treated patients. Goals consistent with normalization or near-normalization should be considered. ClinicalTrials.gov identifiers: NCT00430625, NCT00553631, NCT00635427. Copyright © 2016 Shire Human Genetic Therapies, Inc. Published by Elsevier Inc. All rights reserved.

  15. The use of recombinant human LH (lutropin alfa) in the late stimulation phase of assisted reproduction cycles: a double-blind, randomized, prospective study.

    Science.gov (United States)

    Tarlatzis, B; Tavmergen, E; Szamatowicz, M; Barash, A; Amit, A; Levitas, E; Shoham, Z

    2006-01-01

    The effect of recombinant human LH (r-hLH; lutropin alfa) in women undergoing controlled ovarian stimulation with recombinant human FSH (r-hFSH) prior to IVF was investigated. After down-regulation with the GnRH agonist, buserelin, 114 normo-ovulatory women (aged 18-37 years) received r-hFSH alone until the lead follicle reached a diameter of 14 mm. Patients were then randomized in a double-blind fashion to receive r-hFSH in addition to r-hLH, 75 IU s.c., or placebo daily for a maximum of 10 days prior to oocyte retrieval and IVF. The primary end-point was the number of metaphase II oocytes. There were no significant differences between treatment groups for the primary end-point. Serum estradiol concentrations on the day of HCG administration were significantly higher in the group receiving r-hLH plus r-hFSH than in the group receiving r-hFSH alone (P = 0.0001), but there were no significant differences between the groups in dose and duration of r-hFSH treatment required, oocyte maturation, fertilization rate, pregnancy rate and live birth rate. In this patient population, the addition of r-hLH during the late follicular phase of a long GnRH agonist and r-hFSH stimulation cycle provides no further benefit in terms of oocyte maturation or other end-points.

  16. Evaluation of the efficacy and safety of three dosing regimens of agalsidase alfa enzyme replacement therapy in adults with Fabry disease

    Directory of Open Access Journals (Sweden)

    Goláň L

    2015-07-01

    Full Text Available Lubor Goláň,1 Ozlem Goker-Alpan,2 Myrl Holida,3 Ikka Kantola,4 Mariusz Klopotowski,5 Johanna Kuusisto,6 Aleš Linhart,1 Jacek Musial,7 Kathleen Nicholls,8 Derlis Gonzalez-Rodriguez,9 Reena Sharma,10 Bojan Vujkovac,11 Peter Chang,12 Anna Wijatyk12 1First Faculty of Medicine, Department of Cardiovascular Medicine, Charles University, Prague, Czech Republic; 2Lysosomal Research and Treatment Unit, Fairfax, VA, USA; 3Stead Family Department of Pediatrics, Division of Medical Genetics, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; 4Division of Medicine, Turku University Hospital, Turku, Finland; 5Institute of Cardiology, Warsaw, Poland; 6Department of Medicine, Center for Medicine and Clinical Research, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; 7Department of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland; 8Department of Nephrology, Royal Melbourne Hospital and the University of Melbourne, VIC, Australia; 9Instituto Privado de Hematologia E Investigacion Clinica (IPHIC, Asuncion, Paraguay; 10Salford Royal NHS Foundation Trust, Salford, UK; 11General Hospital Slovenj Gradec, Slovenj Gradec, Slovenia; 12Shire, Lexington, MA, USA Purpose: Efficacy and safety of agalsidase alfa at 0.2 mg/kg weekly were compared with 0.2 mg/kg every other week (EOW. Exploratory analyses were performed for 0.4 mg/kg weekly.Patients and methods: This was a 53-week, Phase III/IV, multicenter, open-label study (NCT01124643 in treatment-naïve adults (≥18 years with Fabry disease. Inclusion criteria were left ventricular hypertrophy at baseline, defined as left ventricular mass indexed to height >50 g/m2.7 for males and >47 g/m2.7 for females. Primary endpoint was reduction of left ventricular mass indexed to height as assessed by echocardiography. Secondary endpoints included cardiac (peak oxygen consumption, 6-minute walk test, Minnesota Living with Heart Failure Questionnaire, New

  17. Actividad biológica de la prostaglandina F2 alfa y del metil carboprost en el fundus gástrico aislado de rata

    Directory of Open Access Journals (Sweden)

    Roberto Rojas Martínez

    1997-08-01

    Full Text Available Se comparó la potencia contráctil de una muestra del éster metílico de 15 metil prostaglandina F2 alfa (metil carboprost (I, producida por la Industria Farmacéutica Cubana, con una muestra comercial de prostaglandina F2 alfa (II, de la firma Chinoin, mediante el ensayo de los "tres puntos". También se comparó la duración de la contracción inducida por dichas muestras utilizando un análisis de regresión lineal de la relajación observada en función del tiempo, luego de suprimir el contacto entre la droga y el órgano efector. Se utilizó el fundus gástrico aislado de rata como órgano efector. La actividad contráctil se registró mediante transductores fuerza-desplazamiento. La muestra I presentó una potencia relativa de 164,0 % con respecto a la II, con límites de confianza de 111,2 y 247,8 % (p=0,95; N=7, y mostró un efecto más prolongado en relación con la II. En las tiras contraídas por la muestra I debió transcurrir 6 min y 46 s, luego del lavado, para que la contracción se redujera a la mitad de la respuesta máxima observada (N=7, en tanto que en las tiras contraídas por la II fue de 1 min y 48 s (N= 8.The contractil potency of a sample of methylic ester of 15 methyl prostaglandin F2 alpha (methyl carboprost (I produced by the Cuban Pharmaceutical Industry, was compared to a commercial sample of prostaglandin F2 alpha (II from a Chinoin firm through the "three point" assay. The duration of the contraction induced by such samples was also compared using the analysis of linear regression of the relaxation observed in function of time after the supression of contact between the drug and the effector organ. The gastric fundus isolated from a rat was used as the effector organ. The contractil activity was recorded by strength-displacement transducers. Sample I showed a relative potency of 164.0 % with respect to sample II, with confidence limits of 111.2 and 247.8 % (P = 0.95; N=7 and it also showed a more prolonged

  18. Clinical relevance of IDH1/2 mutant allele burden during follow-up in acute myeloid leukemia. A study by the French ALFA group

    Science.gov (United States)

    Ferret, Yann; Boissel, Nicolas; Helevaut, Nathalie; Madic, Jordan; Nibourel, Olivier; Marceau-Renaut, Alice; Bucci, Maxime; Geffroy, Sandrine; Celli-Lebras, Karine; Castaigne, Sylvie; Thomas, Xavier; Terré, Christine; Dombret, Hervé; Preudhomme, Claude; Renneville, Aline

    2018-01-01

    Assessment of minimal residual disease has emerged as a powerful prognostic factor in acute myeloid leukemia. In this study, we investigated the potential of IDH1/2 mutations as targets for minimal residual disease assessment in acute myeloid leukemia, since these mutations collectively occur in 15–20% of cases of acute myeloid leukemia and now represent druggable targets. We employed droplet digital polymerase chain reaction assays to quantify IDH1R132, IDH2R140, and IDH2R172 mutations on genomic DNA in 322 samples from 103 adult patients with primary IDH1/2 mutant acute myeloid leukemia and enrolled on Acute Leukemia French Association (ALFA) - 0701 or -0702 clinical trials. The median IDH1/2 mutant allele fraction in bone marrow samples was 42.3% (range, 8.2 – 49.9%) at diagnosis of acute myeloid leukemia, and below the detection limit of 0.2% (range, <0.2 – 39.3%) in complete remission after induction therapy. In univariate analysis, the presence of a normal karyotype, a NPM1 mutation, and an IDH1/2 mutant allele fraction <0.2% in bone marrow after induction therapy were statistically significant predictors of longer disease-free survival. In multivariate analysis, these three variables remained significantly predictive of disease-free survival. In 7/103 (7%) patients, IDH1/2 mutations persisted at high levels in complete remission, consistent with the presence of an IDH1/2 mutation in pre-leukemic hematopoietic stem cells. Five out of these seven patients subsequently relapsed or progressed toward myelodysplastic syndrome, suggesting that patients carrying the IDH1/2 mutation in a pre-leukemic clone may be at high risk of hematologic evolution. PMID:29472349

  19. Potential cost saving of Epoetin alfa in elective hip or knee surgery due to reduction in blood transfusions and their side effects: a discrete-event simulation model.

    Directory of Open Access Journals (Sweden)

    Jörg Tomeczkowski

    Full Text Available OBJECTIVES: Transfusion of allogeneic blood is still common in orthopedic surgery. This analysis evaluates from the perspective of a German hospital the potential cost savings of Epoetin alfa (EPO compared to predonated autologous blood transfusions or to a nobloodconservationstrategy (allogeneic blood transfusion strategyduring elective hip and knee replacement surgery. METHODS: Individual patients (N = 50,000 were simulated based on data from controlled trials, the German DRG institute (InEK and various publications and entered into a stochastic model (Monte-Carlo of three treatment arms: EPO, preoperative autologous donation and nobloodconservationstrategy. All three strategies lead to a different risk for an allogeneic blood transfusion. The model focused on the costs and events of the three different procedures. The costs were obtained from clinical trial databases, the German DRG system, patient records and medical publications: transfusion (allogeneic red blood cells: €320/unit and autologous red blood cells: €250/unit, pneumonia treatment (€5,000, and length of stay (€300/day. Probabilistic sensitivity analyses were performed to determine which factors had an influence on the model's clinical and cost outcomes. RESULTS: At acquisition costs of €200/40,000 IU EPO is cost saving compared to autologous blood donation, and cost-effective compared to a nobloodconservationstrategy. The results were most sensitive to the cost of EPO, blood units and hospital days. CONCLUSIONS: EPO might become an attractive blood conservation strategy for anemic patients at reasonable costs due to the reduction in allogeneic blood transfusions, in the modeled incidence of transfusion-associated pneumonia andthe prolongedlength of stay.

  20. Gaucher disease: transcriptome analyses using microarray or mRNA sequencing in a Gba1 mutant mouse model treated with velaglucerase alfa or imiglucerase.

    Directory of Open Access Journals (Sweden)

    Nupur Dasgupta

    Full Text Available Gaucher disease type 1, an inherited lysosomal storage disorder, is caused by mutations in GBA1 leading to defective glucocerebrosidase (GCase function and consequent excess accumulation of glucosylceramide/glucosylsphingosine in visceral organs. Enzyme replacement therapy (ERT with the biosimilars, imiglucerase (imig or velaglucerase alfa (vela improves/reverses the visceral disease. Comparative transcriptomic effects (microarray and mRNA-Seq of no ERT and ERT (imig or vela were done with liver, lung, and spleen from mice having Gba1 mutant alleles, termed D409V/null. Disease-related molecular effects, dynamic ranges, and sensitivities were compared between mRNA-Seq and microarrays and their respective analytic tools, i.e. Mixed Model ANOVA (microarray, and DESeq and edgeR (mRNA-Seq. While similar gene expression patterns were observed with both platforms, mRNA-Seq identified more differentially expressed genes (DEGs (∼3-fold than the microarrays. Among the three analytic tools, DESeq identified the maximum number of DEGs for all tissues and treatments. DESeq and edgeR comparisons revealed differences in DEGs identified. In 9V/null liver, spleen and lung, post-therapy transcriptomes approximated WT, were partially reverted, and had little change, respectively, and were concordant with the corresponding histological and biochemical findings. DEG overlaps were only 8-20% between mRNA-Seq and microarray, but the biological pathways were similar. Cell growth and proliferation, cell cycle, heme metabolism, and mitochondrial dysfunction were most altered with the Gaucher disease process. Imig and vela differentially affected specific disease pathways. Differential molecular responses were observed in direct transcriptome comparisons from imig- and vela-treated tissues. These results provide cross-validation for the mRNA-Seq and microarray platforms, and show differences between the molecular effects of two highly structurally similar ERT

  1. Potential cost saving of Epoetin alfa in elective hip or knee surgery due to reduction in blood transfusions and their side effects: a discrete-event simulation model.

    Science.gov (United States)

    Tomeczkowski, Jörg; Stern, Sean; Müller, Alfred; von Heymann, Christian

    2013-01-01

    Transfusion of allogeneic blood is still common in orthopedic surgery. This analysis evaluates from the perspective of a German hospital the potential cost savings of Epoetin alfa (EPO) compared to predonated autologous blood transfusions or to a nobloodconservationstrategy (allogeneic blood transfusion strategy)during elective hip and knee replacement surgery. Individual patients (N = 50,000) were simulated based on data from controlled trials, the German DRG institute (InEK) and various publications and entered into a stochastic model (Monte-Carlo) of three treatment arms: EPO, preoperative autologous donation and nobloodconservationstrategy. All three strategies lead to a different risk for an allogeneic blood transfusion. The model focused on the costs and events of the three different procedures. The costs were obtained from clinical trial databases, the German DRG system, patient records and medical publications: transfusion (allogeneic red blood cells: €320/unit and autologous red blood cells: €250/unit), pneumonia treatment (€5,000), and length of stay (€300/day). Probabilistic sensitivity analyses were performed to determine which factors had an influence on the model's clinical and cost outcomes. At acquisition costs of €200/40,000 IU EPO is cost saving compared to autologous blood donation, and cost-effective compared to a nobloodconservationstrategy. The results were most sensitive to the cost of EPO, blood units and hospital days. EPO might become an attractive blood conservation strategy for anemic patients at reasonable costs due to the reduction in allogeneic blood transfusions, in the modeled incidence of transfusion-associated pneumonia andthe prolongedlength of stay.

  2. El receptor de estrógenos alfa como mediador del efecto proliferativo de progestágenos en cáncer de mama

    Directory of Open Access Journals (Sweden)

    Sebastián Giulianelli

    2012-08-01

    Full Text Available En carcinomas mamarios murinos (C4-HD y en células de cáncer de mama humano (T47D observamos que el progestágeno sintético, acetato de medroxiprogesterona (MPA, induce la activación del receptor de estrógenos alfa (REa y su asociación nuclear con el receptor de progesterona (RP. En este trabajo postulamos que dicha interacción a nivel genómico sería fundamental para desarrollar respuestas proliferativas mediadas por progestágenos. Demostramos que el antiestrógeno fulvestrant (FUL, ICI182.780 indujo la regresión completa de tumores C4-HD creciendo con MPA. El progestágeno indujo la expresión temprana de CCND1 y MYC en células T47D y este efecto fue revertido al bloquear el REa. En células tratadas con MPA utilizamos ensayos de inmunoprecipitación de la cromatina (ChIP y corroboramos la colocalización nuclear de RP/REa en los mismos sitios de los promotores de CCND1 y MYC. El ICI no afectó la unión de RP a ambas secuencias regulatorias, pero sí inhibió la unión del REa. Confirmamos la interacción nuclear entre REa y RP en muestras de cáncer de mama humano. Los resultados demuestran que la presencia del REa, interactuando con el RP, en promotores de CCND1 y MYC es fundamental para la transcripción génica y la proliferación celular inducida por el progestágeno.

  3. THE ARECIBO LEGACY FAST ALFA SURVEY. IX. THE LEO REGION H I CATALOG, GROUP MEMBERSHIP, AND THE H I MASS FUNCTION FOR THE LEO I GROUP

    International Nuclear Information System (INIS)

    Stierwalt, Sabrina; Haynes, Martha P.; Giovanelli, Riccardo; Martin, Ann M.; Kent, Brian R.; Saintonge, Amelie; Karachentsev, Igor D.; Karachentseva, Valentina E.

    2009-01-01

    We present the catalog of H I sources extracted from the ongoing Arecibo Legacy Fast ALFA (ALFALFA) extragalactic H I line survey, found within the sky region bounded by 9 h 36 m h 36 m and +08 0 0 . The H I catalog presented here for this 118 deg 2 region is combined with the ones derived from surrounding regions also covered by the ALFALFA survey to examine the large-scale structure in the complex Leo region. Because of the combination of wide sky coverage and superior sensitivity, spatial and spectral resolution, the ALFALFA H I catalog of the Leo region improves significantly on the numbers of low H I mass sources as compared with those found in previous H I surveys. The H I mass function of the Leo I group presented here is dominated by low-mass objects: 45 of the 65 Leo I members have M H I 8 M-odot, yielding tight constraints on the low-mass slope of the Leo I H I mass function. The best-fit slope is α ≅ -1.41 + 0.2 - 0.1. A direct comparison between the ALFALFA H I line detections and an optical search of the Leo I region proves the advantage of the ALFALFA strategy in finding low-mass, gas-rich dwarfs. These results suggest the existence of a significant population of low surface brightness, gas-rich, yet still very low H I mass galaxies, and may reflect the same type of morphological segregation as is seen in the Local Group. While the low-mass end slope of the Leo I H I mass function is steeper than that determined for luminosity functions of the group, the slope still falls short of the values predicted by simulations of structure formation in the lambda cold dark matter paradigm.

  4. Effect of treatment with Omega-3 fatty acids on C-reactive protein and tumor necrosis factor-alfa in hemodialysis patients

    Directory of Open Access Journals (Sweden)

    Hamid Tayyebi-Khosroshahi

    2012-01-01

    Full Text Available C-reactive protein (CRP, a strong independent risk marker of cardiovascular disease (CVD, and tumor necrosis factor-alfa (TNF-α, a known pro-inflammatory cytokine, are elevated and have damaging effects in patients with chronic renal failure (CRF. Omega-3 fatty acids play an important modulatory role in inflammatory responses. The aim of this study is to review the alterations in serum levels of TNF-α, CRP and other parameters caused by omega-3 supplementation in dialysis patients. The clinical trial was performed in 37 patients with end-stage renal disease undergoing dialysis in hemodialysis centers of three university hospitals in Tabriz. Blood samples were obtained from the study patients for hemoglobin, albumin, ferritin, triglyceride, total cholesterol, low-density lipoprotein (LDL and high-density lipoprotein (HDL-cholesterol, TNF-α and high specific-CRP (hs-CRP measurement. The patients received 3 g omega-3 per day for 2 months. The side-effects noticed were nausea, diarrhea and dyspepsia and undesired drug smell. The difference noted in hemoglobin, albumin, ferritin, CRP, triglyceride, total, LDL and HDL-cholesterol before and after supplementation with omega-3 fatty acid was not statistically significant (P > 0.05. However, the use of omega-3 decreased the serum levels of TNF-α significantly. We conclude that the use of 3 g of omega-3 per day caused significant decrease in serum levels of TNF-α in the dialysis population, and its use is recommended in such patients.

  5. Efeitos do alfa-tocoferol nas lesões de isquemia-reperfusão induzidas em pata direita de ratos

    Directory of Open Access Journals (Sweden)

    Bitu-Moreno José

    2001-01-01

    Full Text Available Recentes estudos demonstraram que os radicais livres de oxigênio parecem desempenhar papel importante nas lesões de isquemia-reperfusão. O alfa-tocoferol(AT age in vivo como um anti-oxidante. Nosso objetivo foi o de verificar se o AT atenuava as lesões de isquemia-reperfusão em pata direita de ratos. Os animais, randomizados, foram divididos nos seguintes grupos(G: G1-controle sem isquemia; G2 e G3 - quatro horas isquemia e duas reperfusão. Os animais do G2 foram tratados com salina e os do G3 com AT, 50mg/kg. Como parâmetros examinamos as alterações de volume e circunferência do pé direito ao longo do experimento, assim como a captação de 99mTc-pirofosfato e a microscopia eletrônica de transmissão do músculo soleus direito. Os aumentos de volume e circunferência do pé dos animais do G2 foram estatisticamente maiores quando comparados com o G1. As medidas do G3 não diferiram do G1. A captação de 99mTc-pirofosfato foi bem aumentada nos G2 e G3, quando comparados ao G1, porém sem diferenças entre os grupos isquêmicos. As lesões ao MET foram menos intensas em três animais do G3, quando comparados ao G2. Conclusão: O tratamento com AT diminuiu a formação do edema mas só protegeu parcialmente as células musculares contra as lesões de isquemia-reperfusão.

  6. Avaliação do perfil hematológico de portadores de talassemia alfa provenientes das regiões Sudeste e Nordeste do Brasil Evaluation of alpha thalassemia carriers hematologic profile from Southeast and Northeast Brazilian regions

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    Gislane L. V. Oliveira

    2006-06-01

    Full Text Available A talassemia alfa é uma anemia hereditária resultante da síntese deficiente de cadeias alfa, provocando um excesso relativo de cadeias beta, que vão formar tetrâmeros identificados como hemoglobina H (Hb H no indivíduo adulto. Para direcionar o diagnóstico laboratorial desta anemia, a análise dos índices eritrocitários, a eletroforese em acetato de celulose em pH neutro e a pesquisa de corpos de inclusão de Hb H são essenciais. O objetivo deste estudo foi traçar o perfil hematológico, por meio dos índices eritrocitários, dos portadores de talassemia alfa das regiões Sudeste e Nordeste do Brasil. Foram analisadas 1.010 amostras de sangue periférico após consentimento informado. Os índices eritrocitários como contagem de glóbulos vermelhos (RBC, dosagem de hemoglobina (HGB, hematócrito (HCT, volume corpuscular médio (VCM, hemoglobina corpuscular média (HCM e concentração de hemoglobina corpuscular média (CHCM foram fornecidos por aparelhos automatizados com controle de qualidade interno e externo. Para o diagnóstico de talassemia alfa foram utilizados testes de triagem e complementares para talassemias, como eletroforese em pH neutro e pesquisa de corpos de inclusão de Hb H com coloração de azul cresil brilhante. Comparando-se os valores hematológicos observados nos dois grupos, notou-se que, em ambas as regiões, os índices com valores discrepantes foram os níveis de HGB e HCT, sendo a maior freqüência de variação observada entre as mulheres. Nos portadores do fenótipo alfa talassêmico da região Nordeste, todos os índices eritrocitários estavam abaixo dos valores de normalidade. Estes resultados evidenciam a necessidade de melhor avaliação do perfil hematológico de talassemia alfa em diferentes regiões, considerando-se os interferentes ambientais para um diagnóstico mais preciso.Alpha thalassemia is a hereditary anaemia resulting from deficient synthesis of the alpha chains, causing a relative

  7. Patrones de diversidad alfa en tres fragmentos de bosques montanos en la región norte de los Andes, Colombia

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    Wilson López

    2010-03-01

    Full Text Available En el presente trabajo se analizaron los patrones de diversidad alfa en tres áreas protegidas de bosque con base en información florística proveniente de seis parcelas permanentes de 1ha -dos en cada área protegida-. Las regiones de estudio están localizadas a lo largo de un gradiente altitudinal, en la parte norte de la cordillera central de los Andes, Colombia. Para los análisis, se generaron dos categorías de acuerdo al tamaño de los árboles: dosel (diámetro a la altura del pecho mayor o igual a 10cm y sotobosque (diámetro a la altura del pecho mayor o igual a un cm y menor a 10cm. Las curvas especies-área mostraron diferencias en riqueza para las dos categorías de tamaño en las tres regiones. Las curvas especies-individuos, en cambio, fueron independientes con respecto al tamaño de los individuos, excepto en la región de Belmira. La diversidad, medida con el índice alfa de Fisher, mostró una fuerte tendencia a la estabilización en muestras mayores a 1 000 individuos. Ni las curvas de especies-área ni las de especies-individuos fueron asintóticas; sin embargo, la tasa de acumulación de especies (z en Belmira alcanzó valores muy bajos (0.05 en comparación con Anorí y Angelópolis (0.25 en cada caso. El índice alfa de Fisher permitió además entender la magnitud de las diferencias relativas en diversidad entre regiones o tipos de bosque en gradientes altitudinales, aun cuando el tamaño de la muestra fue relativamente pequeño. Los resultados de este estudio soportan la limitación en dispersión como el principal mecanismo en estructurar las comunidades de especies a escalas muy finas, y un incremento continuo de procesos denso-dependientes en determinar la estructura de la comunidad en escalas espaciales más grandes. Igualmente, los resultados de este estudio proponen que la denso-dependencia tiende a aumentar positivamente con la altitud.Alpha diversity patterns in three fragmented forests of Northern Andes

  8. Artvin, Rize ve Trabzon’daki Doğal Kaynak Sularında Toplam Alfa, Toplam Beta Aktivite Değerlerinin Belirlenmesi ve Jeoistatistiksel Olarak Modellenmesi

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    Yaşar Kobya

    2014-11-01

    Full Text Available Trabzon, Rize ve Artvin yaklaşık 18000km2 alan üzerine kurulmuş ve yaklaşık 2 milyon insanın yaşadığı Türkiye’nin en kuzey doğusunda bulunan üç ildir. Bu üç ilde toplam 20 tane içme suyu kaynağından örnekler alındı ve bunların toplam alfa, toplam beta aktivite değerleri Berthold LB770 marka alfa, beta sayım cihazı kullanılarak belirlendi. Toplam alfa aktivite değerleri 1.7-114.2 Bq/L ve toplam beta aktivite değerleri ise 2.9-90.8 Bq/L aralıklarında ölçüldü. Bulunan bu değerler dünya sağlık örgütü (WHO’nün limit değerleri ve yapılmış diğer benzer çalışmalarla karşılaştırıldı. Elde edilen veriler için klasik istatistik hesaplamalar yapıldı. Ayrıca jeoistatistik analiz yöntemi kullanılarak eş-doz eğrileri oluşturuldu ve harita üzerinde gösterilerek bölge için bir risk haritası oluşturuldu.

  9. Análisis cuantitativo de cuarzo-alfa en mezclas de cemento portland anhidro y calcita sintética por difracción de rayos X con equipo Philips PW-1700

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    Sagrera-Moreno, J. L.

    1985-09-01

    Full Text Available In this article there are explained the necessary steps to make up a quantitative analysis of alpha-quartz applying the technique of rays X diffraction, in artificial mixtures of anhydrous portland cement and synthetic calcite, which contents are known.

    En el presente artículo se explican los pasos necesarios para realizar un análisis cuantitativo de cuarzo-alfa aplicando la técnica de difracción de rayos X en mezclas artificiales de cemento portland anhidro y calcita sintética, cuyos contenidos son conocidos.

  10. Experiencia con las reacciones adversas asociadas con el interferón alfa 2b recombinante en hematología Experience with the adverse reactions associated with recombinant alpha 2b interferon in hematology

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    Idalmis Brito Pascual

    2005-08-01

    Full Text Available El interferón alfa 2b es una citoquina con actividad antiviral, antiproliferativa e inmunomoduladora que ha demostrado ser eficaz para el tratamiento de enfermedades virales y neoplásicas. El presente trabajo se realizó con el propósito de describir la frecuencia de las reacciones adversas asociada con la administración de Heberon alfa R (interferón alfa 2b recombinante en enfermedades hematológicas. Se analizaron las características de base de los pacientes, así como la frecuencia, intensidad y relación de causalidad de los eventos reportados. Los eventos adversos más frecuentes fueron las manifestaciones del síndrome gripal que incluyó fiebre, escalofrío, astenia, mialgias, anorexia y cefalea. Estas manifestaciones son transitorias y responden al tratamiento con antiinflamatorios no esteroideos. La mayoría de los eventos fueron de intensidad leve a moderada y no requirieron la suspensión del tratamiento. En conclusión, el Heberon alfa R es un fármaco relativamente seguro para el tratamiento de trastornos hematológicosAlpha 2b interferon is a cytokine with antiviral, antiproliferative and immunomodulator activity that has proved to be efficient for the treatment of viral and neoplastic diseases, This paper is aimed at describing the frequency of adverse reactions associated with the administration of alpha R Heberon (recombinant alpha 2b interferon in hematological diseases. The basic characteristics of the patients, as well as the frequency, intensity and causality relation of the reported events were analyzed. The most common adverse effects were the manifestations of the gripal syndrome that included fever, chills, astenia, myalgia, anorexia and headache. These manifestations are transitory and respond to the treatment with non-steroideal antiinflammatory drugs. Most of the events were from mild to moderate intensity and did not require the suspension of the treatment. To conclude, alpha R Heberon is a relatively safe drug

  11. Seguridad de la terapia de interferón alfa 2b recombinante más ribavirina en la hepatitis crónica C Safety of recombinant interferon alpha 2b plus ribavirin in chronic hepatitis C

    OpenAIRE

    Yoan Antonio Sánchez Rodríguez; Enrique Arús Soler; Pedro López Saura; Hugo Nodarse Cuní

    2011-01-01

    INTRODUCCIÓN: la hepatitis crónica C ha adquirido rango de pandemia. El virus de la hepatitis C se ha convertido en la causa principal de hepatitis crónica, cirrosis hepática, hepatocarcinoma, y trasplante de hígado a nivel mundial. OBJETIVO: identificar los efectos adversos asociados a la terapia combinada interferón alfa 2b recombinante más ribavirina durante la evolución del tratamiento y hasta 8 semanas después de finalizado, así como los principales efectos asociados a salidas temporales...

  12. Análise de crédito por meio de modelos de previsão de insolvência: um estudo de caso na Empresa Cerâmica Alfa S.A. = Credit analysis through models for the forcasting of insolvency of the company Cerâmica Alfa S.A.

    Directory of Open Access Journals (Sweden)

    Paula Bez Birolo

    2011-07-01

    Full Text Available O objetivo deste artigo é avaliar os benefícios da utilização de modelos de previsão de insolvência para a análise de crédito em uma empresa do setor cerâmico. É descritivo, de caráter quantitativo, realizado por meio de um estudo de caso na empresa Cerâmica ALFA S.A. Para execução da pesquisa selecionou-se intencionalmente seis clientes, de acordo com os seguintes dados: a informações creditícias disponíveis no sistema gerencial de crédito/cobrança e b demonstrações contábeis divulgadas nos sites dos respectivos clientes. Os resultados apontam que os modelos de Elizabetsky e Kanitz demonstram fragilidades em identificar a situação financeira dos clientes. O modelo de previsão de insolvência desenvolvido por Matias apresenta melhor desempenho, em relação aos anteriores, para a análise de crédito. Conclui-se que é vantajoso utilizar o modelo de Matias para a análise de crédito, pois ele é adequado às necessidades da empresa e serve como um instrumento para auxílio na concessão de crédito e tomada de decisão. The objective of this article is to assess the benefits of using insolvency forecasting models for the credit analysis of a company in the ceramic sector. This study is descriptive of a quantitative nature through a case study in Cerâmica ALFA S.A. Six clients with the following data were intentionally selected for the execution of the research: a credit information available in the credit/collection management system and b account statements divulged in the sites of the respective clients. The results show that the Elizabetsky and Kanitz models demonstrated fragility in identifying the financial situation of the clients. The insolvency forecasting model developed by Matias showed better performance in relation to the previous ones for credit analysis. It was concludrd that it is advantageous to use the Matias model for credit analysis, because it is suitable for the company’s requirements and serves

  13. Determination of the total cross section in proton-proton collisions at the LHC at √(s) = 8 from elastic scattering using the ALFA sub-detector of ATLAS

    Energy Technology Data Exchange (ETDEWEB)

    Heinz, Christian; Stenzel, Hasko; Dueren, Michael [2. Physikalisches Institut, Universitaet Giessen (Germany)

    2016-07-01

    The ALFA (Absolute Luminosity for ATLAS) Roman Pot detector system is part of the forward instrumentation of ATLAS located about 240 m away from the interaction point in the LHC tunnel in both directions. ALFA consists of a scintillating fibre tracker housed in vertical Roman Pots which enables the measurement of elastic proton-proton scattering at small scattering angles. In 2012 data were recorded at a centre-of-mass energy of √(s) = 8 TeV during a fill with special beam optics of the LHC with β* = 90 m and parallel-to-point focusing. The four-momentum transfer t is measured for elastically scattered protons and used to extract the differential elastic cross section. In this talk a preliminary determination of the total cross section and of the slope of the elastic cross section at small vertical stroke t vertical stroke obtained from a fit to the differential cross section using the optical theorem is reported. In addition a second run at √(s) = 8 TeV with a special beam optics of β* = 1 km, providing access to the Coulomb-nuclear interference region, is being analysed. Preliminary analysis results from this run are presented as well.

  14. Phase III Prospective Randomized Comparison Trial of Depot Octreotide Plus Interferon Alfa-2b Versus Depot Octreotide Plus Bevacizumab in Patients With Advanced Carcinoid Tumors: SWOG S0518.

    Science.gov (United States)

    Yao, James C; Guthrie, Katherine A; Moran, Cesar; Strosberg, Jonathan R; Kulke, Matthew H; Chan, Jennifer A; LoConte, Noelle; McWilliams, Robert R; Wolin, Edward M; Mattar, Bassam; McDonough, Shannon; Chen, Helen; Blanke, Charles D; Hochster, Howard S

    2017-05-20

    Purpose Treatment options for neuroendocrine tumors (NETs) remain limited. This trial assessed the progression-free survival (PFS) of bevacizumab or interferon alfa-2b (IFN-α-2b) added to octreotide among patients with advanced NETs. Patients and Methods Southwest Oncology Group (SWOG) S0518, a phase III study conducted in a US cooperative group system, enrolled patients with advanced grades 1 and 2 NETs with progressive disease or other poor prognostic features. Patients were randomly assigned to treatment with octreotide LAR 20 mg every 21 days with either bevacizumab 15 mg/kg every 21 days or 5 million units of IFN-α-2b three times per week. The primary end point was centrally assessed PFS. This trial is registered with ClinicalTrials.gov as NCT00569127. Results A total of 427 patients was enrolled, of whom 214 were allocated to bevacizumab and 213 to IFN-α-2b. The median PFS by central review was 16.6 months (95% CI, 12.9 to 19.6 months) in the bevacizumab arm and was 15.4 months (95% CI, 9.6 to 18.6 months) in the IFN arm (hazard ratio [HR], 0.93; 95% CI, 0.73 to 1.18; P = .55). By site review, the median PFS times were 15.4 months (95% CI, 12.6 to 17.2 months) for bevacizumab and 10.6 months (95% CI, 8.5 to 14.4 months) for interferon (HR, 0.90; 95% CI, 0.72 to 1.12; P = .33). Time to treatment failure was longer with bevacizumab than with IFN (HR, 0.72; 95% CI, 0.58 to 0.89; P = .003). Confirmed radiologic response rates were 12% (95% CI, 8% to 18%) for bevacizumab and 4% (95% CI, 2% to 8%) for IFN. Common adverse events with bevacizumab and octreotide included hypertension (32%), proteinuria (9%), and fatigue (7%); with IFN and octreotide, they included fatigue (27%), neutropenia (12%), and nausea (6%). Conclusion No significant differences in PFS were observed between the bevacizumab and IFN arms, which suggests that these agents have similar antitumor activity among patients with advanced NETs.

  15. Albinterferon Alfa-2b was not inferior to pegylated interferon-α in a randomized trial of patients with chronic hepatitis C virus genotype 1.

    Science.gov (United States)

    Zeuzem, Stefan; Sulkowski, Mark S; Lawitz, Eric J; Rustgi, Vinod K; Rodriguez-Torres, Maribel; Bacon, Bruce R; Grigorescu, Mircea; Tice, Alan D; Lurie, Yoav; Cianciara, Janusz; Muir, Andrew J; Cronin, Patrick W; Pulkstenis, Erik; Subramanian, G Mani; McHutchison, John G

    2010-10-01

    The current standard of care for patients with chronic hepatitis C virus (HCV) genotype 1 is once-weekly pegylated interferon-α (Peg-IFNα) plus daily ribavirin for 48 weeks. We evaluated the efficacy/safety of albinterferon alfa-2b (albIFN), a novel, long-acting, genetic fusion polypeptide of albumin and IFNα-2b. In the phase 3 ACHIEVE-1 trial, 1331 patients were assigned equally to 3 open-label, 48-week treatment groups: Peg-IFNα-2a 180 μg every week, or albIFN 900 or 1200 μg every 2 weeks administered subcutaneously, with weight-based oral ribavirin 1000-1200 mg/day. During the study, the data monitoring committee recommended dose modification for all patients receiving albIFN 1200 μg to 900 μg because of increased pulmonary adverse events (AEs) in the 1200-μg arms of both ACHIEVE studies. Main outcome measure was sustained virologic response (SVR; undetectable serum HCV RNA at week 72). Intention-to-treat SVR rates were 51.0% (225/441), 48.2% (213/442), and 47.3% (208/440) with Peg-IFNα-2a, and albIFN 900 and 1200 μg, respectively. The primary objective of showing noninferiority of albIFN 900 μg (P < .001) and 1200 μg (P = .003) vs Peg-IFNα-2a for SVR was achieved. Multivariate modeling indicated consistency of treatment effect across subgroups. Serious/severe AE rates were 23.1%, 24.0%, 28.2%; treatment discontinuation rates because of AEs were 4.1%, 10.4%, 10.0%; discontinuation rates because of respiratory AEs were 0%, 0.9%, 1.6%; with Peg-IFNα-2a, and albIFN 900 and 1200 μg, respectively. Hematologic abnormality rates were comparable across the Peg-IFNα-2a and albIFN 900-μg groups. albIFN 900 μg every 2 weeks showed comparable efficacy, with similar serious/severe AE rates, although with a higher discontinuation rate, vs Peg-IFNα-2a in patients with chronic HCV genotype 1. Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.

  16. The effectiveness of retreatment with peginterferon alfa and ribavirin in patients with chronic viral hepatitis C genotype 2 and 3: a prospective cohort study in Brazil.

    Science.gov (United States)

    Artico, Simara; Amaral, Karine Medeiros; Gonçalves, Candice Beatriz Treter; Picon, Paulo Dornelles

    2012-12-27

    More than 50% of patients infected with chronic hepatitis C virus (HCV) do not respond to treatment with conventional interferon (IFN) combined with ribavirin (RBV). The aim of our study was to evaluate the effectiveness of retreatment with peginterferon alfa-2a or 2b (PEG-IFN 2a or 2b) concomitantly with RBV in patients with HCV genotype 2 and 3, which were non-responders or relapsers to initial treatment with IFN / RBV and to identify possible predictors of sustained virological response (SVR). From September 2003 to March 2009 a cohort of 216 patients who had previously failed therapy with a regimen of standard interferon and ribavirin, were followed in a specialized service implemented in the Brazilian Unified Health System, Rio Grande do Sul. All patients were retreated with PEG-IFN 2a or 2b per week, associated with RBV, through oral route, with doses determined according to weight (1,000 mg if weight ≤ 75 Kg and 1,250 mg if ≥ 75 Kg) per day for 48 weeks. The HCV-RNA was tested by Polymerase Chain Reaction (PCR). Virological Response (VR) within 48 weeks and SVR in the 72 weeks was considered for evaluation of treatment efficacy. Analyses were performed in patients who received at least one dose of PEG-IFN. The SVR rate for non-responders to previous treatment was 34.4% and for relapsers was 50% (p = 0.031). As predictive factors that contribute to improve SVR, were identified the age (p = 0.005), to be relapsers to previous treatment (p = 0.023) and present liver biopsy examination Metavir F0-F2 (p = 0.004). In assessing the safety profile, 51 patients (23.6%) discontinued treatment prematurely. This alternative retreatment for patients who have failed prior therapies for anti-HCV, has demonstrated promising SVR rate, provided that it includes a careful selection of patients with predictors of response and adverse events monitored.

  17. The effectiveness of retreatment with peginterferon alfa and ribavirin in patients with chronic viral hepatitis C genotype 2 and 3: a prospective cohort study in Brazil

    Directory of Open Access Journals (Sweden)

    Artico Simara

    2012-12-01

    Full Text Available Abstract Background More than 50% of patients infected with chronic hepatitis C virus (HCV do not respond to treatment with conventional interferon (IFN combined with ribavirin (RBV. The aim of our study was to evaluate the effectiveness of retreatment with peginterferon alfa-2a or 2b (PEG-IFN 2a or 2b concomitantly with RBV in patients with HCV genotype 2 and 3, which were non-responders or relapsers to initial treatment with IFN / RBV and to identify possible predictors of sustained virological response (SVR. Methods From September 2003 to March 2009 a cohort of 216 patients who had previously failed therapy with a regimen of standard interferon and ribavirin, were followed in a specialized service implemented in the Brazilian Unified Health System, Rio Grande do Sul. All patients were retreated with PEG-IFN 2a or 2b per week, associated with RBV, through oral route, with doses determined according to weight (1,000 mg if weight ≤ 75 Kg and 1,250 mg if ≥ 75 Kg per day for 48 weeks. The HCV-RNA was tested by Polymerase Chain Reaction (PCR. Virological Response (VR within 48 weeks and SVR in the 72 weeks was considered for evaluation of treatment efficacy. Analyses were performed in patients who received at least one dose of PEG-IFN. Results The SVR rate for non-responders to previous treatment was 34.4% and for relapsers was 50% (p = 0.031. As predictive factors that contribute to improve SVR, were identified the age (p = 0.005, to be relapsers to previous treatment (p = 0.023 and present liver biopsy examination Metavir F0-F2 (p = 0.004. In assessing the safety profile, 51 patients (23.6% discontinued treatment prematurely. Conclusions This alternative retreatment for patients who have failed prior therapies for anti-HCV, has demonstrated promising SVR rate, provided that it includes a careful selection of patients with predictors of response and adverse events monitored.

  18. Early virologic response and IL28B polymorphisms in patients with chronic hepatitis C genotype 3 treated with peginterferon alfa-2a and ribavirin.

    Science.gov (United States)

    Scherzer, Thomas-Matthias; Hofer, Harald; Staettermayer, Albert Friedrich; Rutter, Karoline; Beinhardt, Sandra; Steindl-Munda, Petra; Kerschner, Heidrun; Kessler, Harald H; Ferenci, Peter

    2011-05-01

    Polymorphisms of the IL28B gene (rs12979860 and rs8099917) are associated with high sustained virological response (SVR) rates in HCV genotype 1 patients. This study analyzes the impact of these IL28B polymorphisms on early treatment response (weeks 2 and 4) and SVR in HCV genotype 3 patients. rs12979860 and rs8099917 were analyzed by the Step-OnePlus Real-time PCR system in 71 out of 72 Caucasian HCV genotype 3 patients participating, at our center, in a randomized study comparing 400mg with 800 mg ribavirin/day. HCV RNA was determined at weeks 2 and 4 of 180 μg/week peginterferon alfa-2a/ribavirin treatment. Sixty-nine patients completed the treatment and follow-up. rs12979860 genotyping revealed that 27 (37.5%) patients had C/C, 39 (54.2%) T/C, and 5 (6.9%) T/T. Thirteen patients (18.1%) became HCV RNA negative at week 2 and an additional 30 (41.7%) at week 4 (rapid virologic response; RVR); thus a total of 43 had a RVR (C/C: 77.8%; T/C or T/T: 50.0%). Irrespective of the ribavirin dose, the viral load decline was larger than in those with the T allele (T/C or T/T) (week 2: 4.46; [0.36-6.02] median; [range] vs. 3.50; [0.14-5.62]; log IU HCV-RNA/ml; p<0.001; week 4: 4.97; [1.21-6.20] vs. 4.49; [1.16-6.23]; p=0.003). Despite the faster initial viral response in C/C carriers, SVR rates were not different compared to T-allele carriers. Results of the SNP in the rs8099917 region were similar. IL28B polymorphisms modulate early virologic response to peginterferon/ribavirin treatment. In contrast to HCV genotype 1 patients, no effect on SVR rates was observed in genotype 3 patients. The clinical relevance of an earlier viral decline in C/C patients needs to be determined. Copyright © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

  19. Use of darbepoetin alfa in European clinical practice for the management of chemotherapy-induced anaemia in four tumour types: final data from the CHOICE study.

    Science.gov (United States)

    Aerts, J G; Swieboda-Sadlej, A; Karanikiotis, C; Labourey, J-L; Galid, A; Wheeler, T; Pujol, B; Van Belle, S

    2012-07-01

    The CHOICE study was a prospective, multicentre, observational study designed to assess levels of adherence in current clinical practice to the European product label and EORTC guidelines for the treatment of chemotherapy-induced anaemia (CIA) with darbepoetin alfa (DA). Here we present data split by tumour types: breast, colorectal, ovarian and lung. Haemoglobin (Hb) levels and red blood cell transfusion requirements were evaluated among patients with solid tumours in 11 European countries. The primary outcome measure was the proportion of patients with a target Hb level of ≥10-≤12 g/dL. The full analysis set included 1887 patients (mean ± SD 62.4 ± 11.4 years); 1585 (84%) had a current disease stage of ≥3. Common chemotherapy regimens were non-platinum + non-taxane based (n = 696 [37%]) or platinum + non-taxane based (n = 660 [35%]). Breast cancer (n = 575): The mean ± SD Hb level at baseline was 9.9 ± 0.8 g/dL (n = 568). Target Hb level was reached by 187 (55%) patients. Colorectal cancer (n = 310): At baseline the mean ± SD Hb level was 9.8 ± 0.8 g/dL (n = 306). Target Hb level was reached by 107 patients (56%). Ovarian cancer (n = 301): The mean ± SD Hb level at baseline was 9.7 ± 0.8 g/dL (n = 294). Target Hb level was reached by 81 patients (44%). Lung cancer (n = 701): At baseline the mean ± SD Hb level was 9.8 ± 0.9 g/dL (n = 692). Target Hb level was reached by 142 patients (39%). Five severe or life-threatening adverse drug reactions were seen (three patients with breast cancer, one patient with colorectal cancer and one patient with ovarian cancer). Potential bias could not be excluded due to the study's observational nature. This study demonstrates that the recommendations are adhered to in clinical practice, with the mean starting Hb level type. Furthermore, DA is likely to be effective and well tolerated for the treatment of CIA in

  20. Recombinant follitropin alfa/lutropin alfa in fertility treatment

    Directory of Open Access Journals (Sweden)

    Ahmed Gibreel

    2009-12-01

    Full Text Available Ahmed Gibreel1, Siladitya Bhattacharya21School of Medicine and Dentistry, University of Aberdeen; 2Aberdeen Maternity Hospital, Aberdeen, UKAbstract: Recombinant human follicle stimulating hormone (rFSH and luteinizing hormone (LH, also known as follitropin alpha and lutropin alpha, are manufactured by genetic engineering techniques which ensure high quality and batch to batch consistency. Follitropin alpha can be used for controlled ovarian hyperstimulation in assisted reproduction, ovulation induction for WHO group I and II anovulatory infertility and in men with hypogonadotrophic hypogonadism (HH or idiopathic oligo-asthenospermia. Current evidence suggests superiority of urinary human menopausal gonadotropin (HMG over follitropin alpha in controlled ovarian hyperstimulation for IVF in terms of live birth rate per couple. Addition of lutropin to follitropin alpha in an unselected IVF population does not appear to confer any benefit; however, it may have a role in ovulation induction in women with hypothalamic hypogonadism. Urinary HMG preparations (especially currently available highly purified preparations are more cost effective than rFSH in terms of cost per ongoing pregnancy. However, women using rFSH injection pen devices have higher levels of satisfaction as compared to those using urinary HMG by means of conventional syringes.Keywords: infertility, follicle stimulating hormone, luteinizing hormone, follitropin alpha, lutropin alpha, in-vitro fertilization, urinary gonadotrophins

  1. Efeito da suplementação com vitamina E sobre a concentração de alfa-tocoferol no colostro humano Effect of vitamin E supplementation on alpha-tocopherol levels in human colostrum

    Directory of Open Access Journals (Sweden)

    Roberto Dimenstein

    2011-06-01

    Full Text Available OBJETIVO: Avaliar a concentração de alfa-tocoferol no colostro humano em condições de suplementação com cápsulas de vitamina A acrescidas de vitamina E sintética. MÉTODOS: Foram recrutadas para o estudo 30 parturientes saudáveis atendidas em uma maternidade pública. Após jejum noturno, foram coletadas amostras de sangue e de colostro (2 mL das parturientes. Após a primeira coleta, as mesmas receberam suplemento na forma de uma cápsula de palmitato de retinila (200000 UI ou 60 mg acrescido de vitamina E sintética (49,4 mg de dl-alfa-tocoferol. Após 24 horas da suplementação, foi realizada nova coleta de 2 mL de colostro, também em jejum. RESULTADOS: A concentração sérica de alfa-tocoferol foi de 1 042,9 ± 319,0 μg/dL. Os teores de alfa-tocoferol no colostro antes da suplementação foram de 1155,4 ± 811,0 μg/dL, vs. 1396,3 ± 862,2 μg/dL 24 horas depois da suplementação (P > 0,05. Foi encontrada correlação entre o alfa-tocoferol do colostro na condição de jejum antes da suplementação e 24 horas após a suplementação (P = 0,001; r = 0,58, mas não entre soro e o colostro em nenhuma das condições acima citadas. CONCLUSÕES: Não houve aumento na concentração de alfa-tocoferol do colostro 24 horas após a suplementação. Isso indica que não é vantajoso suplementar a mãe com vitamina E sintética. Entretanto, os resultados também sugerem que, se o estado nutricional prévio à suplementação estiver adequado, mais tocoferol será encontrado no colostro após a suplementação. Novos estudos devem ser realizados para investigar o efeito da suplementação com a forma natural do alfa-tocoferol.OBJECTIVE: To assess the levels of alpha-tocopherol in human colostrum following supplementation with capsules containing vitamin A plus synthetic vitamin E. METHODS: Thirty healthy women about to give birth were recruited from a public maternity hospital. After overnight fasting, blood samples as well as colostrum

  2. Frutificação e crescimento de frutos em abóbora híbrida 'Tetsukabuto' tratada com alfa-naftalenoacetato de sódio Fruit set and fruit growth of 'Tetsukabuto' squash treated with the sodium salt of alfa-naphthaleneacetic acid

    Directory of Open Access Journals (Sweden)

    Cassandro V.T. do Amarante

    2000-11-01

    Full Text Available A abertura de flores femininas na abóbora híbrida 'Tetsukabuto' concentra-se num período de três a quatro semanas. Este curto período de florescimento indica que uma polinização deficiente pode ocasionar grande comprometimento da produção de frutos. Este trabalho foi conduzido com o objetivo de avaliar o efeito de concentrações do fitorregulador alfa-naftalenoacetato de sódio (ANA-Na, pulverizado em flores abertas femininas, na frutificação e crescimento de frutos da abóbora 'Tetsukabuto'. O experimento foi conduzido em Lages, SC, na safra 1992/1993, seguindo o delineamento em blocos casualizados, com três repetições. A parcela foi constituída de cinco covas de 'Tetsukabuto' e uma da polinizadora Cucurbita maxima, em espaçamento de 3 x 1 m, com duas plantas/cova. Os tratamentos utilizados foram testemunha (polinização natural e 150, 300, 450, 600 e 750 mg·L-1 de ANA-Na. Nos tratamentos com ANA-Na, evitou-se a polinização natural isolando-se as flores com sacos de papel. Avaliou-se percentagem de frutificação, peso, comprimento e diâmetro dos frutos e peso, espessura, rendimento e sólidos totais da polpa. Apenas a dose de 750 mg·L-1 do hormônio reduziu a percentagem de frutificação. Os frutos obtidos por tratamento com ANA-Na apresentaram crescimento similar ao dos frutos obtidos por polinização.Anthesis of female flowers of 'Tetsukabuto' squash occurs within three to four weeks. A deficient pollination during this short flowering period may reduce the yield. The sodium salt of alfa-naphthaleneacetic acid (Na-NAA can be used to improve fruit set when pollination is deficient. This work was conducted to investigate the effects of different concentrations of Na-NAA, sprayed in open female flowers on fruit set and fruit growth of 'Tetsukabuto' squash. The experiment was carried out in 1992-93, in South Brazil, in a randomized block design with three replicates. The plots had a proportion of five plants of

  3. PERCEPCIÓN DEL IMPACTO DE LA APLICACIÓN DE MECANISMOS DE ASEGURAMIENTO DE LA CALIDAD EN LA EDUCACIÓN SUPERIOR EN COSTA RICA: PROYECTO ALFA-CINDA-UNIVERSIDAD DE COSTA RICA (PERCEIVED IMPACT OF QUALITY ASSURANCE MECHANISMS ON COSTA-RICAN HIGHER EDUCATION: THE ALFA-CINDA-UNIVERSIDAD-DE-COSTA-RICA PROJECT

    Directory of Open Access Journals (Sweden)

    Guido Guido, Elsiana

    2012-05-01

    Full Text Available Resumen: En este artículo se presentan las acciones realizadas dentro del Proyecto Alfa Nro. DCl-ALA 2008/42: Aseguramiento de la calidad: políticas públicas y gestión universitaria financiado con fondos de la Unión Europea y coordinado, de manera general, por el Centro Interuniversitario de Desarrollo, CINDA. Participan 16 universidades latinoamericanas y 7 universidades europeas, y el objetivo general del proyecto es mejorar la gestión de la calidad de la Educación Superior, tanto a nivel de los sistemas nacionales como de las instituciones de Educación Superior, y contribuir con la generación de conocimiento y confianzas mutuas acerca de la calidad de la Educación Superior entre los países latinoamericanos y europeos. Como parte de las actividades desarrolladas se llevaron a cabo estudios en 7 países (5 de Latinoamérica y 2 de Europa para evaluar el impacto de los procesos de aseguramiento de la calidad implementados en las universidades. En Costa Rica, el proyecto ha sido coordinado y ejecutado por la Universidad de Costa Rica desde el año 2009 hasta la fecha. El estudio se realizó en dos universidades estatales y dos privadas, durante el período comprendido entre octubre de 2010 y mayo de 2011, se realizaron 26 entrevistas presenciales y 8 sesiones de grupo a las diferentes poblaciones definidas en el estudio, además, se realizaron un total de 652 encuestas a estudiantes activos y a personas egresadas. Los principales resultados obtenidos en Costa Rica se resumen en este artículo, de acuerdo con los niveles y dimensiones de calidad que fueron definidos en el marco referencial del proyecto.Abstract: The article presents actions carried out in Costa Rica, in the frame of the project Alfa Nro. DCl-ALA 2008/42: Quality assurance: public policies and management in universities. This project is funded by the European Commission and its general coordination is in charge of the Inter-university Center for Development (CINDA, in

  4. Peginterferon Alfa-2a Injection

    Science.gov (United States)

    ... and polyethylene glycol, which helps the interferon stay active in your body for a longer period of ... 2a comes as a solution (liquid) in a vial, a prefilled syringe, and a disposable autoinjector to ...

  5. Arroz integral, seleno-levedura e acetato de alfa-tocoferol na dieta de frangos de corte: efeitos sobre a qualidade da carne

    Directory of Open Access Journals (Sweden)

    Aline Arassiana Piccini Roll

    2017-05-01

    Full Text Available Foram estudados os efeitos da suplementação com acetato de alfa-tocoferol (VE e seleno-levedura (SeL Sel-Plex, Alltech® Inc, sobre o pH, a capacidade de retenção de água (CRA, perdas por cocção (PC, perdas por gotejamento (PG, cor do músculo e a concentração de selênio no peito de frangos alimentados com dietas a base de milho ou arroz. A partir de 21 dias de idade 200 frangos de corte Cobb foram alojados em 38 boxes (unidade experimental num delineamento casualizado num arranjo fatorial 2x2x2 em que foram fixados os níveis de suplementação “on top” de VE (0 e 200 mg/kg, SeL (0 e 0,3 ppm e dois ingredientes da dieta (100% milho e 100% arroz integral totalizando oito tratamentos: T1 milho + 0SeL + 0VE (controle; T2 milho + 200mg/kg VE + 0SeL; T3 milho + 0VE + 0,3ppm SeL; T4 milho + 200mg/kg VE + 0,3ppm SeL; T5 arroz + 0VE +0SeL; T6 arroz + 200mg/kg VE + 0SeL; T7 arroz + 0VE + 0,3ppm SeL; T8 arroz + 200mg/kg VE + 0,3ppm SeL. A quantidade de selênio no peito foi maior (P < 0,0001 com a inclusão de 200mg/kg de VE, em comparação com os demais tratamentos. Entretanto, observou-se uma interação positiva entre VE e SeL na dieta sobre a quantidade de selênio recuperada na carne (P = 0,06. Foi encontrada melhor CRA com a inclusão de SeL e VE em dietas a base de arroz. A substituição do milho por arroz nas dietas reduziu a cor amarela na carne (P < 0,05. PC e PG não foram significativamente afetadas pelos tratamentos. O pH da carne do peito foi significativamente mais elevado nas aves recebendo dietas suplementadas de SeL. Em conclusão, a interação entre VE e SeL aumenta o selênio na carne, porém, melhorando a CRA somente em dietas a base de arroz. A substituição de milho por arroz integral reduz a intensidade da coloração amarela da carne do peito de frangos.

  6. Prediction of Ovarian Hyperstimulation Syndrome in Patients Treated with Corifollitropin alfa or rFSH in a GnRH Antagonist Protocol.

    Directory of Open Access Journals (Sweden)

    Georg Griesinger

    Full Text Available What is the threshold for the prediction of moderate to severe or severe ovarian hyperstimulation syndrome (OHSS based on the number of growing follicles ≥ 11 mm and/or estradiol (E2 levels?The optimal threshold of follicles ≥11 mm on the day of hCG to identify those at risk was 19 for both moderate to severe OHSS and for severe OHSS. Estradiol (E2 levels were less prognostic of OHSS than the number of follicles ≥ 11 mm.In comparison to long gonadotropin-releasing hormone (GnRH agonist protocols, the risk of severe OHSS is reduced by approximately 50% in a GnRH antagonist protocol for ovarian stimulation prior to in vitro fertilisation (IVF, while the two protocols provide equal chances of pregnancy per initiated cycle. Nevertheless, moderate to severe OHSS may still occur in GnRH antagonist protocols if human chorionic gonadotropin (hCG is administered to trigger final oocyte maturation, especially in high responder patients. Severe OHSS following hCG trigger may occur with an incidence of 1-2% in a relatively young (aged 18 to 36 years IVF population treated in a GnRH-antagonist protocol.From the Engage, Ensure and Trust trials, in total, 2,433 women who received hCG for oocyte maturation and for whom the number of follicles ≥ 11 mm and the level of E2 on the day of hCG administration were known were included in the analyses.The threshold for OHSS prediction of moderate and severe OHSS was assessed in women treated with corifollitropin alfa or daily recombinant follicle stimulation hormone (rFSH in a gonadotropin-releasing hormone (GnRH-antagonist protocol. Receiver operating characteristics curve analyses for moderate to severe OHSS and severe OHSS were performed on the combined dataset and the sensitivity and specificity for the optimal threshold of number of follicles ≥ 11 mm, E2 levels on the day of (hCG, and a combination of both, were determined.The optimal threshold of follicles ≥ 11 mm on the day of hCG to identify those at

  7. ATLASGAL-selected massive clumps in the inner Galaxy. II. Characterisation of different evolutionary stages and their SiO emission

    Science.gov (United States)

    Csengeri, T.; Leurini, S.; Wyrowski, F.; Urquhart, J. S.; Menten, K. M.; Walmsley, M.; Bontemps, S.; Wienen, M.; Beuther, H.; Motte, F.; Nguyen-Luong, Q.; Schilke, P.; Schuller, F.; Zavagno, A.; Sanna, C.

    2016-02-01

    Context. The processes leading to the birth of high-mass stars are poorly understood. The key first step to reveal their formation processes is characterising the clumps and cores from which they form. Aims: We define a representative sample of massive clumps in different evolutionary stages selected from the APEX Telescope Large Area Survey of the Galaxy (ATLASGAL), from which we aim to establish a census of molecular tracers of their evolution. As a first step, we study the shock tracer, SiO, mainly associated with shocks from jets probing accretion processes. In low-mass young stellar objects (YSOs), outflow and jet activity decreases with time during the star formation processes. Recently, a similar scenario was suggested for massive clumps based on SiO observations. Here we analyse observations of the SiO (2-1) and (5-4) lines in a statistically significant sample to constrain the change of SiO abundance and the excitation conditions as a function of evolutionary stage of massive star-forming clumps. Methods: We performed an unbiased spectral line survey covering the 3-mm atmospheric window between 84-117 GHz with the IRAM 30 m telescope of a sample of 430 sources of the ATLASGAL survey, covering various evolutionary stages of massive clumps. A smaller sample of 128 clumps has been observed in the SiO (5-4) transition with the APEX telescope to complement the (2-1) line and probe the excitation conditions of the emitting gas. We derived detection rates to assess the star formation activity of the sample, and we estimated the column density and abundance using both an LTE approximation and non-LTE calculations for a smaller subsample, where both transitions have been observed. Results: We characterise the physical properties of the selected sources, which greatly supersedes the largest samples studied so far, and show that they are representative of different evolutionary stages. We report a high detection rate of >75% of the SiO (2-1) line and a >90% detection rate from the dedicated follow-ups in the (5-4) transition. Up to 25% of the infrared-quiet clumps exhibit high-velocity line wings, suggesting that molecular tracers are more efficient tools to determine the level of star formation activity than infrared colour criteria. We also find infrared-quiet clumps that exhibit only a low-velocity component (FWHM ~ 5-6 km s-1) SiO emission in the (2-1) line. In the current picture, where this is attributed to low-velocity shocks from cloud-cloud collisions, this can be used to pinpoint the youngest, thus, likely prestellar massive structures. Using the optically thin isotopologue (29SiO), we estimate that the (2-1) line is optically thin towards most of the sample. Furthermore, based on the line ratio of the (5-4) to the (2-1) line, our study reveals a trend of changing excitation conditions that lead to brighter emission in the (5-4) line towards more evolved sources. Our models show that a proper treatment of non-LTE effects and beam dilution is necessary to constrain trends in the SiO column density and abundance. Conclusions: We conclude that the SiO (2-1) line with broad line profiles and high detection rates is a powerful probe of star formation activity in the deeply embedded phase of the evolution of massive clumps. The ubiquitous detection of SiO in all evolutionary stages suggests a continuous star formation process in massive clumps. Our analysis delivers a more robust estimate of SiO column density and abundance than previous studies and questions the decrease of jet activity in massive clumps as a function of age. The observed increase of excitation conditions towards the more evolved clumps suggests a higher pressure in the shocked gas towards more evolved or more massive clumps in our sample. Full Tables 4, 6, 7 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/586/A149

  8. Comportamiento de glicinina, beta-conglicinina y alfa-amilasa en semillas de soja deterioradas y no deterioradas Glycinin, beta-conglycinin and alpha-amylase behaviour in artificially deteriorated and not deteriorated soybean

    Directory of Open Access Journals (Sweden)

    Adriana Rita Salinas

    2002-08-01

    Full Text Available El objetivo del trabajo fue estudiar el comportamiento de glicinina y beta-conglicinina y la actividad de alfa-amilasa en semillas deterioradas y no deterioradas de 10 cultivares de soja [Glycine max (L. Merr.]. Las semillas se sometieron a dos tratamientos: deterioradas por envejecimiento acelerado y no deterioradas. Se determinó la presencia de las proteínas de reserva a partir de semillas con 0, 3 y 8 días de germinadas por electroforesis en geles de poliacrilamida (SDS-PAGE. La actividad de la alfa-amilasa se determinó bioquímicamente en semillas con 0, 3, 8 y 12 días de germinadas. No hubo diferencias en la presencia de bandas de glicinina y beta-conglicinina en semillas no deterioradas hasta los 8 días de germinadas. Las semillas deterioradas se comportaron en forma similar a las no deterioradas. La actividad de la alfa-amilasa aumentó en semillas germinadas hasta 8 días y disminuyó a los 12 días. En semillas deterioradas la actividad enzimática disminuyó con respecto a las no deterioradas. El deterioro artificial no afectó la presencia de glicinina y beta-conglicinina pero alteró la actividad de la alfa-amilasa hasta los 12 días de germinación. Los cultivares estudiados mostraron comportamiento diferencial frente a la actividad de esta enzima.The objective of this research was to study the behaviour of the storage proteins glycinin and beta-conglycinin and the alpha-amylase activity in artificially deteriorated and not deteriorated soybean [Glycine max (L. Merr.] seeds of 10 cultivars. The seeds were submitted to two treatments: deteriorated by accelerated aging and not deteriorated seeds. The presence of glycinin and beta-conglycinin were determined in seeds with 0, 3 and 8 days of germination using polyacrylamid gel electrophoresis (SDS-PAGE. The alpha-amylase activity was biochemically determined in seeds with 0, 3, 8 and 12 days of germination. There were no differences in the presence of glycinin and beta

  9. Streptomyces sp. MC10 SUŞUNUN ALFA AMİLAZ ÜRETİM KABİLİYETİNİN BELİRLENMESİ - DETERMINATION OF ABILITY OF ALPHA AMYLASE PRODUCTION BY Streptomyces sp. MC10 STRAIN

    OpenAIRE

    ÖZDEMİR, Ali; SIDAL, Uğur

    2013-01-01

    Streptomyces sp. MC10 SUŞUNUN ALFA AMİLAZ ÜRETİM KABİLİYETİNİN BELİRLENMESİAmilazlar en önemli endüstriyel enzimlerden biridir. Amilaz üreticisi olan Streptomyces MC10 suşu Manisa Celal Bayar Üniversitesinden alınan toprak örneklerinden izole edilmiştir. Bu çalışmada Streptomyces MC10 suşundan α-amilaz üretimi ve karakterizasyonu gerçekleştirilmiştir. Bu amaçla suşun besiyerinde üremesi ve α-amilaz üretme yeteneği ve aktivite gösterdiği optimum sıcaklık, pH, inkübasyon süresi ve substrat kons...

  10. New digital ink for the obtention of innovating ceramics effects to obtain new possibilities and tendencies for the future; Este trabajo ha sido premiado con el Alfa de Oro en la Feria Internacional de Ceramica de Valencia CEVISAMA 2012

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    This technical note contains the most significant aspects of the work New digital inks for the production of innovative ceramic effects which generate new possibilities and future trends in which the Group Torrecid won the Alfa de Oro 2012 given by the Spanish Society of Ceramics and Glass. To achieve the stated objectives to work in different fields of activity for each specific ink has been necessary, comprising, among other, aspects such as the development of special frits, selecting the most suitable solvents or optimizing the compositions to ensure that the inks have appropriate behaviour in the printing process and met all the requirements of stability and quality that the ceramic industry demand. (Author)

  11. Impact of non-migrating tides on the low latitude ionosphere during a sudden stratospheric warming event in January 2010

    Science.gov (United States)

    McDonald, S. E.; Sassi, F.; Tate, J.; McCormack, J.; Kuhl, D. D.; Drob, D. P.; Metzler, C.; Mannucci, A. J.

    2018-06-01

    The lower atmosphere contributes significantly to the day-to-day variability of the ionosphere, especially during solar minimum conditions. Ionosphere/atmosphere model simulations that incorporate meteorology from data assimilation analysis products can be critically important for elucidating the physical processes that have substantial impact on ionospheric weather. In this study, the NCAR Whole Atmosphere Community Climate Model, extended version with specified dynamics (SD-WACCM-X) is coupled with an ionospheric model (Sami3 is Another Model of the Ionosphere) to study day-to-day variability in the ionosphere during January 2010. Lower atmospheric weather patterns are introduced into the SAMI3/SD-WACCM-X simulations using the 6-h Navy Operational Global Atmospheric Prediction System-Advanced Level Physics High Altitude (NOGAPS-ALPHA) data assimilation products. The same time period is simulated using the new atmospheric forecast model, the High Altitude Navy Global Environmental Model (HA-NAVGEM), a hybrid 4D-Var prototype data assimilation with the ability to produce meteorological fields at a 3-h cadence. Our study shows that forcing SD-WACCM-X with HA-NAVGEM better resolves the semidiurnal tides and introduces more day-to-day variability into the ionosphere than forcing with NOGAPS-ALPHA. The SAMI3/SD-WACCM-X/HA-NAVGEM simulation also more accurately captures the longitudinal variability associated with non-migrating tides in the equatorial ionization anomaly (EIA) region as compared to total electron content (TEC) maps derived from GPS data. Both the TEC maps and the SAMI3/SD-WACCM-X/HA-NAVGEM simulation show an enhancement in TEC over South America during 17-21 January 2010, which coincides with the commencement of a stratospheric warming event on 19 January 2010. Analysis of the SAMI3/SD-WACCM-X/HA-NAVGEM simulations indicates non-migrating tides (including DW4, DE2 and SW5) played a role during 17-21 January in shifting the phase of the wave-3 pattern in the ionosphere on these days. Constructive interference of wave-3 and wave-4 patterns in the E × B drifts contributed to the enhanced TEC in the South American longitude sector. The results of the study highlight the importance of high fidelity meteorology in understanding the day-to-day variability of the ionosphere.

  12. A simulation of equatorial plasma bubble signatures on the OI 6300A nightglow meridional profile over Brazilian low latitude

    International Nuclear Information System (INIS)

    Nakamura, Y.; Sobral, J.H.A.; Abdu, M.A.

    1981-11-01

    A quantitative interpretation of the meridional propagation of the airglow disturbance for events that have their onsets well westward of the photometer observing longitude, representing the post growth phase of a bubble, is attempted by carrying out a numerical simulation of the phenomenon. Airglow intensity as a function of zenith angle in the photometer scanning range was calculated using electron density profiles perturbed by field aligned plasma bubble whose vertical velocity and electron density depletion profile were determined from a numerical simulation of the nonlinear Rayleigh-Taylor instability under ionospheric conditions that best represented those of the observing period and location. (L.C.) [pt

  13. Statistical characteristics of ionogram spread-F and satellite traces over a Chinese low-latitude station Sanya

    Science.gov (United States)

    Zhu, Zhengping; Lan, Jiaping; Luo, Weihua; Sun, Fenglou; Chen, Kun; Chang, Shanshan

    2015-11-01

    Ionosonde ionogram measurements over Sanya (18°N, 109°E; 13°N dip latitude), China during 2012-2013 are used to investigate the occurrence characteristics of spread-F (SF) and satellite traces (STs), and the possible correlation between them under the weak solar maximum of solar cycle 24. The SF and STs were manually identified from ionograms. The results show that the diurnal pattern of SF peaks at post-sunset during equinox, and at post-midnight during summer months, respectively. By classifying the SF into range spread-F (RSF) and frequency spread-F (FSF), it is found that the SF during equinox are mostly RSF associated with the equatorial F-region irregularities and can be explained by the generalized Rayleigh-Taylor instability. A statistics on the RSF and STs shows that not all RSF events were preceded by STs, and not all STs led to RSF development. The monthly mean value of the sunset ionospheric F2 layer peak height (hmF2) on RSF days is apparently higher than that on non RSF days. This result provides statistically consistent evidence that both the sunset rapid rising of the F-layer and the presence of F-region bottomside density perturbations (as indicated by STs) are important factors for the equinoctial RSF onset and development. However in summer months, the occurrences of RSF and FSF are comparable. Most FSF initiated at midnight. And there was no close relationship between the summer time FSF, F-layer height increase and STs. We suggest that the midnight FSF during summer months observed over Sanya might not be resulting from the decaying of post-sunset RSF initiated at equatorial latitude, but due to the quite localized generation of F-region irregularities.

  14. The detection of annual hypoxia in a low latitude freshwater reservoir in Kerala, India, using the small AUV Maya

    Digital Repository Service at National Institute of Oceanography (India)

    Desa, E.S.; Madhan, R.; Maurya, P.K.; Navelkar, G.S.; Mascarenhas, A.A.M.Q.; Prabhudesai, S.; Afzulpurkar, S.; Desa, E.; Pascoal, A.M.; Nambiar, M.

    dead reckoning methods that involve the integration of the DVL velocities in an inertial frame of reference. The underwater Z coordinate is not estimated but set equal to the pressure transducer output in meters. Simple Line of Sight (LOS) way...

  15. Long-period fading in atmospherics during severe meteorological activity and associated solar geophysical phenomena at low latitudes

    Directory of Open Access Journals (Sweden)

    A. B. Bhattacharya

    1998-02-01

    Full Text Available The records of VLF atmospherics over Calcutta and then over Kalyani (West Bengal during the torrential rainfall, caused by violent monsoon and post-monsoon depressions, exhibit distinct long-period fadings both at day and night. Interesting results obtained from an analysis of round-the-clock atmospherics data and associated meteorological parameters are reported in this paper. A possible correlation between the severe meteorological activity with the solar geophysical phenomena was studied. The results are indicative of an interesting sequence of solar-terrestrial events. A tentative conclusion is reached, suggesting an origin of the fading from atmospheric gravity waves generated in the centre of activity of the depressions concerned.Key words. Meteorology and atmospheric dynamics · Lightning · Precipitation

  16. Lightning-generated whistler waves observed by probes on the Communication/Navigation Outage Forecast System satellite at low latitudes

    Science.gov (United States)

    Holzworth, R. H.; McCarthy, M. P.; Pfaff, R. F.; Jacobson, A. R.; Willcockson, W. L.; Rowland, D. E.

    2011-06-01

    Direct evidence is presented for a causal relationship between lightning and strong electric field transients inside equatorial ionospheric density depletions. In fact, these whistler mode plasma waves may be the dominant electric field signal within such depletions. Optical lightning data from the Communication/Navigation Outage Forecast System (C/NOFS) satellite and global lightning location information from the World Wide Lightning Location Network are presented as independent verification that these electric field transients are caused by lightning. The electric field instrument on C/NOFS routinely measures lightning-related electric field wave packets or sferics, associated with simultaneous measurements of optical flashes at all altitudes encountered by the satellite (401-867 km). Lightning-generated whistler waves have abundant access to the topside ionosphere, even close to the magnetic equator.

  17. Umbria-Marche Basin, Central Italy: A Reference Section for the Aptian-Albian Interval at Low Latitudes

    Directory of Open Access Journals (Sweden)

    Renato Paes de Almeida

    2012-04-01

    Full Text Available Within the Cretaceous Period, the Aptian-Albian interval (125–99.6 Ma, Ogg et al., 2008 was a critical time on a global scale. This is evident from 1 changes in the nature of the ocean-climate system brought about by increased ocean crust production coupled with active midplate and plate margin volcanism in a shifting paleogeography (Skelton et al., 2003; 2 cyclic deposition and preservation of common “black shales”, some of them termed Oceanic Anoxic Events(OAE1a to OAE1d (Schlanger and Jenkyns, 1976; Arthur et al., 1990; 3 periodic changes in redox conditions at the ocean bottom (Oceanic Red Beds, ORBs (Wang et al., 2009; and 4 rapid biotic radiations and turnovers (Leckie et al., 2002. The Aptian-Albian time is also of interest for one of the most noteworthy geomagnetic events, namely the post-M0r “Cretaceous Quiet Zone”. This long and constant normal polarity superchron without any convincing true reversal to date (Satolli et al., 2008 precludes usage of reversals magnetostratigraphy from the Aptian through the Santonian. The Poggio le Guaine core was designed to provide a high-resolution age model and a high-resolution relative magnetic paleointensity reference curve for the Aptian-Albian interval of the long normal Cretaceous superchron; it was also designed to understand the causal linkages among geological, biogeochemical, oceanographic and climatic eventsas well as their consequences. The core was drilled at Poggio le Guaine, where the most continuous, complete, and best preserved Aptian-Albian succession is exposed throughout the Umbria-Marche Basin (UMB of the northern Apennines of central Italy (Fig. 1. It represents a continuous record of fossiliferous pelagic rocks extending from the Albian-Cenomanian boundary down to the uppermost Barremian (99.6–126 Ma. In this progress report we present the first preliminary findings of this ongoing project.

  18. Seasonal variation of low-latitude E-region plasma irregularities studied using Gadanki radar and ionosonde

    Directory of Open Access Journals (Sweden)

    D. V. Phanikumar

    2008-07-01

    Full Text Available In this paper, we present seasonal variation of E region field-aligned irregularities (FAIs observed using the Gadanki radar and compare them with the seasonal variation of Es observed from a nearby location SHAR. During daytime, FAIs occur maximum in summer and throughout the day, as compared to other seasons. During nighttime, FAIs occur equally in both summer and winter, and relatively less in equinoxes. Seasonal variations of Es (i.e. ftEs and fbEs show that the daytime activity is maximum in summer and the nighttime activity is maximum in equinoxes. No relation is found between FAIs occurrence/SNR and ftEs/fbEs. FAIs occurrence, however, is found to be related well with (ftEs−fbEs. This aspect is discussed in the light of the present understanding of the mid-latitude Es-FAIs relationship. The seasonal variations of FAIs observed at Gadanki are compared in detail with those of Piura, which show a significant difference in the daytime observations. The observed difference has been discussed considering the factors governing the generation of FAIs.

  19. Seasonal variation of low-latitude E-region plasma irregularities studied using Gadanki radar and ionosonde

    Directory of Open Access Journals (Sweden)

    D. V. Phanikumar

    2008-07-01

    Full Text Available In this paper, we present seasonal variation of E region field-aligned irregularities (FAIs observed using the Gadanki radar and compare them with the seasonal variation of Es observed from a nearby location SHAR. During daytime, FAIs occur maximum in summer and throughout the day, as compared to other seasons. During nighttime, FAIs occur equally in both summer and winter, and relatively less in equinoxes. Seasonal variations of Es (i.e. ftEs and fbEs show that the daytime activity is maximum in summer and the nighttime activity is maximum in equinoxes. No relation is found between FAIs occurrence/SNR and ftEs/fbEs. FAIs occurrence, however, is found to be related well with (ftEs−fbEs. This aspect is discussed in the light of the present understanding of the mid-latitude Es-FAIs relationship. The seasonal variations of FAIs observed at Gadanki are compared in detail with those of Piura, which show a significant difference in the daytime observations. The observed difference has been discussed considering the factors governing the generation of FAIs.

  20. Dawn-dusk asymmetries and sub-Alfvénic flow in the high and low latitude magnetosheath

    Directory of Open Access Journals (Sweden)

    M. Longmore

    2005-11-01

    Full Text Available We present the results of a statistical survey of the magnetosheath using four years of Cluster orbital coverage. Moments of the plasma distribution obtained from the electron and ion instruments together with magnetic field data are used to characterise the flow and density in the magnetosheath. We note two important differences between our survey and the gasdynamic model predictions: a deceleration of the flow at higher latitudes close to the magnetopause, resulting in sub-Alfvénic flow near the cusp, and a dawn-dusk asymmetry with higher velocity magnitudes and lower densities measured on the dusk side of the magnetosheath in the Northern Hemisphere. The latter observation is in agreement with studies carried out by Paularena et al. (2001, Němeček et al. (2000, and Šafránková et al. (2004. In equations of hydrodynamics for a single-component additon to this we observe a reverse of this asymmetry for the Southern Hemisphere. High-latitude sub-Alfvénic flow is thought to be a necessary condition for steady state reconnection pole-ward of the cusp.

  1. Cascading effects of climate extremes on vertebrate fauna through changes to low-latitude tree flowering and fruiting phenology.

    Science.gov (United States)

    Butt, Nathalie; Seabrook, Leonie; Maron, Martine; Law, Bradley S; Dawson, Terence P; Syktus, Jozef; McAlpine, Clive A

    2015-09-01

    Forest vertebrate fauna provide critical services, such as pollination and seed dispersal, which underpin functional and resilient ecosystems. In turn, many of these fauna are dependent on the flowering phenology of the plant species of such ecosystems. The impact of changes in climate, including climate extremes, on the interaction between these fauna and flora has not been identified or elucidated, yet influences on flowering phenology are already evident. These changes are well documented in the mid to high latitudes. However, there is emerging evidence that the flowering phenology, nectar/pollen production, and fruit production of long-lived trees in tropical and subtropical forests are also being impacted by changes in the frequency and severity of climate extremes. Here, we examine the implications of these changes for vertebrate fauna dependent on these resources. We review the literature to establish evidence for links between climate extremes and flowering phenology, elucidating the nature of relationships between different vertebrate taxa and flowering regimes. We combine this information with climate change projections to postulate about the likely impacts on nectar, pollen and fruit resource availability and the consequences for dependent vertebrate fauna. The most recent climate projections show that the frequency and intensity of climate extremes will increase during the 21st century. These changes are likely to significantly alter mass flowering and fruiting events in the tropics and subtropics, which are frequently cued by climate extremes, such as intensive rainfall events or rapid temperature shifts. We find that in these systems the abundance and duration of resource availability for vertebrate fauna is likely to fluctuate, and the time intervals between episodes of high resource availability to increase. The combined impact of these changes has the potential to result in cascading effects on ecosystems through changes in pollinator and seed dispersal ecology, and demands a focused research effort. © 2015 John Wiley & Sons Ltd.

  2. Prismatic TIR (total internal reflection) low-concentration PV (photovoltaics)-integrated façade for low latitudes

    International Nuclear Information System (INIS)

    Sabry, Mohamed

    2016-01-01

    Low-concentration Façade-integrated Photovoltaic system in the form of TIR (total internal reflection) prismatic segmented façade could play an effective role in reducing the direct component of solar radiation transmitting through buildings, hence reducing both cooling and artificial lighting load on such buildings. A prismatic segmented façade is capable of allowing diffused skylight to transmit through it to the building interior, while preventing most of the direct solar radiation and converting it into clean energy by means of the integrated PV (​photovoltaics) cells. A range of prismatic TIR segmented façades with different head angles has been designed based on the geographical latitude of the chosen location. Each façade configuration is simulated by ray-tracing technique and its performance is investigated against realistic direct solar radiation data in two clear sky days representing summer and winter of the targeted location. Ray tracing simulations revealed that all of the selected configurations could collect most of the direct solar radiation in summer. In contrary, larger head angle of the segmented façade could collect wider intervals around the noon time till reaching a head angle of 23° at which most of the incident direct solar radiation could be collected. - Highlights: • 5 different head angles of prismatic segmented PV-integrated Façade are ray-traced. • Transmitted and PV-collected solar radiation percentages are determined. • DNI daily profiles with associated solar altitudes and azimuth data are simulated. • Expected transmitted and PV collected solar radiation are calculated for the proposed segments.

  3. Study of TEC, slab-thickness and neutral temperature of the thermosphere in the Indian low latitude sector

    Directory of Open Access Journals (Sweden)

    K. Venkatesh

    2011-09-01

    Full Text Available The ionospheric equivalent slab-thickness is an important parameter which measures the skewness of the electron density profile of the ionosphere. In this paper, the diurnal, seasonal, day-to-day and latitudinal variations of ionospheric parameters namely total electron content (TEC, the peak ionization density of F-layer (NmF2, equivalent slab-thickness (τ and neutral temperature (Tn are presented. The simultaneous data of GPS-TEC and NmF2 from Trivandrum (8.47° N, 76.91° E, Waltair (17.7° N, 83.3° E and Delhi (28.58° N, 77.21° E are used to compute the slab-thickness (τ = TEC/NmF2 of the low sunspot period, 2004–2005. The day-time TEC values at Waltair are found to be greater than those at Trivandrum, while at Delhi the day-time TEC values are much lower compared to those at Trivandrum and Waltair. The trends of variation in the monthly mean diurnal variation of TEC and NmF2 are similar at Delhi, while th