WorldWideScience

Sample records for ingelheim promeco contemplates

  1. Boehringer Ingelheim Promeco contemplates the benefits of cogeneration in its new plant; Boehringer Ingelheim Promeco contempla beneficios de la cogeneracion para su nueva planta

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz Esparza, R. [Instituto de Investigaciones Electricas, Cuernavaca (Mexico); Khouri Solis, A. [Boehringer Ingelheim Promeco, Mexico, D. F. (Mexico)

    1997-12-31

    This paper presents the results of the feasibility study performed in BOEHRINGER INGELHEIM PROMECO to determine the benefits that a cogeneration system could render in satisfying the energy demand of its plant currently being expanded. The results showed that in accordance with the operation mode of the already expanded plant, the highest benefits could be obtained of a cogeneration system with a capacity of 1,600 Kw that would partially satisfy the thermal and electrical demands of BOEHRINGER INGELHEIM PROMECO. [Espanol] El presente articulo presenta los resultados de factibilidad que se realizo en Boehringer Ingelheim Promeco para determinar los beneficios que podria rendir un sistema de cogeneracion al satisfacer las demandas energeticas de su planta actualmente en ampliacion. Los resultados mostraron que de acuerdo al modo de operacion de la planta ya ampliada, los beneficios mas altos se obtendrian de un sistema de cogeneracion con capacidad de 1,600 kW que satisfaria parcialmente las demandas termicas y electricas de Boehringer Ingelheim Promeco.

  2. Boehringer Ingelheim Promeco contemplates the benefits of cogeneration in its new plant; Boehringer Ingelheim Promeco contempla beneficios de la cogeneracion para su nueva planta

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz Esparza, R [Instituto de Investigaciones Electricas, Cuernavaca (Mexico); Khouri Solis, A [Boehringer Ingelheim Promeco, Mexico, D. F. (Mexico)

    1998-12-31

    This paper presents the results of the feasibility study performed in BOEHRINGER INGELHEIM PROMECO to determine the benefits that a cogeneration system could render in satisfying the energy demand of its plant currently being expanded. The results showed that in accordance with the operation mode of the already expanded plant, the highest benefits could be obtained of a cogeneration system with a capacity of 1,600 Kw that would partially satisfy the thermal and electrical demands of BOEHRINGER INGELHEIM PROMECO. [Espanol] El presente articulo presenta los resultados de factibilidad que se realizo en Boehringer Ingelheim Promeco para determinar los beneficios que podria rendir un sistema de cogeneracion al satisfacer las demandas energeticas de su planta actualmente en ampliacion. Los resultados mostraron que de acuerdo al modo de operacion de la planta ya ampliada, los beneficios mas altos se obtendrian de un sistema de cogeneracion con capacidad de 1,600 kW que satisfaria parcialmente las demandas termicas y electricas de Boehringer Ingelheim Promeco.

  3. 78 FR 64016 - Importer of Controlled Substances, Notice of Registration, Boehringer Ingelheim Chemicals

    Science.gov (United States)

    2013-10-25

    ... Registration, Boehringer Ingelheim Chemicals By Notice dated June 18, 2013, and published in the Federal Register on July 1, 2013, 78 FR 39337, Boehringer Ingelheim Chemicals, 2820 N. Normandy Drive, Petersburg...) and determined that the registration of Boehringer Ingelheim Chemicals is consistent with the public...

  4. 77 FR 67397 - Importer Of Controlled Substances; Notice of Registration; Boehringer Ingelheim Chemicals, Inc.

    Science.gov (United States)

    2012-11-09

    ... Registration; Boehringer Ingelheim Chemicals, Inc. By Notice dated July 17, 2012, and published in the Federal Register on July 26, 2012, 77 FR 43861, Boehringer Ingelheim Chemicals, Inc., 2820 N. Normandy Drive...), and determined that the registration of Boehringer Ingelheim Chemicals, Inc., to import the basic...

  5. 78 FR 64018 - Manufacturer of Controlled Substances; Notice of Registration; Boehringer Ingelheim Chemicals, Inc.

    Science.gov (United States)

    2013-10-25

    ...; Notice of Registration; Boehringer Ingelheim Chemicals, Inc. By Notice dated June 18, 2013, and published in the Federal Register on July 1, 2013, 78 FR 39340, Boehringer Ingelheim Chemicals, Inc., 2820 N... 21 U.S.C. 823(a) and determined that the registration of Boehringer Ingelheim Chemicals, Inc., to...

  6. 78 FR 39337 - Importer of Controlled Substances, Notice of Application, Boehringer Ingelheim Chemicals

    Science.gov (United States)

    2013-07-01

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances, Notice of Application, Boehringer Ingelheim Chemicals Pursuant to Title 21 Code of Federal Regulations 1301.34(a), this is notice that on May 31, 2013, Boehringer Ingelheim Chemicals, 2820 N. Normandy Drive, Petersburg...

  7. 77 FR 43861 - Importer of Controlled Substances; Notice of Application; Boehringer Ingelheim Chemicals

    Science.gov (United States)

    2012-07-26

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances; Notice of Application; Boehringer Ingelheim Chemicals Pursuant to Title 21 Code of Federal Regulations 1301.34(a), this is notice that on June 8, 2012, Boehringer Ingelheim Chemicals, Inc., 2820 N. Normandy Drive...

  8. 77 FR 43863 - Manufacturer of Controlled Substances; Notice of Application; Boehringer Ingelheim Chemicals Inc.

    Science.gov (United States)

    2012-07-26

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Boehringer Ingelheim Chemicals Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on June 8, 2012, Boehringer Ingelheim Chemicals...

  9. 78 FR 39340 - Manufacturer of Controlled Substances; Notice of Application; Boehringer Ingelheim Chemicals, Inc.

    Science.gov (United States)

    2013-07-01

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Boehringer Ingelheim Chemicals, Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on May 31, 2013, Boehringer Ingelheim Chemicals...

  10. 77 FR 70188 - Manufacturer of Controlled Substances; Notice of Registration; Boehringer Ingelheim Chemicals, Inc.

    Science.gov (United States)

    2012-11-23

    ...; Notice of Registration; Boehringer Ingelheim Chemicals, Inc. By Notice dated July 17, 2012, and published in the Federal Register on July 26, 2012, 77 FR 43863, Boehringer Ingelheim Chemicals, Inc., 2820 N... has considered the factors in 21 U.S.C. 823(a) and determined that the registration of Boehringer...

  11. Contemplative Media Studies

    Directory of Open Access Journals (Sweden)

    Kevin Healey

    2015-08-01

    Full Text Available The psychological and socio-economic implications of digital technologies call for scholarship that engages questions about the nature of human consciousness, the construction of the self and the ethics of technical development. In this article, I outline a framework for an approach called contemplative media studies. This approach incorporates several different scholarly threads, namely: via critical political-economic media scholarship, a focus on achieving social and economic justice through policy initiatives and structural reform; via media and religious scholarship, an interest in the religious dimensions of digital culture and the role of media in shaping religious identity; and via contemplative studies, an appreciation of the applicability of contemplative principles to research methods and theory. This framework allows us to examine the spiritual ideology that drives the construction of commercial digital platforms and to ask whether alternative platforms might better catalyze human development. Anchored in a critical commitment to socio-economic justice, contemplative media studies is aimed at articulating an ethically-responsive and economically-sustainable architecture of human flourishing.

  12. Contemplative Science and Secular Ethics

    Directory of Open Access Journals (Sweden)

    Brendan Ozawa-de Silva

    2016-08-01

    Full Text Available This article argues that the emerging project of contemplative science will be best served if it is informed by two perspectives. First, attention should be paid not only to non-analytical and/or mindfulness-based practices, but to a fuller range of contemplative practices, including analytical styles of meditation. Second, the issue of ethics must be addressed as a framework within which to understand contemplative practice: both theoretically in order to understand better the practices themselves and the traditions they come from, and practically in order to understand the ways in which contemplative practices are deployed in contemporary societies. The Tibetan Buddhist Lojong (blo sbyong tradition and secularized practices derived from it, which are now an area of study in contemplative science, are examined as a kind of case study in order to make these two points and illustrate their importance and relevance for the future of this emerging field.

  13. Was Paul among the contemplatives?

    Directory of Open Access Journals (Sweden)

    James Panaggio

    2016-09-01

    Full Text Available This article offers a critique of the contemporary Contemplative Tradition’s view of spiritual transformation from the lens of the universally accepted letters of Paul. The article argues that contemporary contemplatives, especially Dallas Willard and Richard Foster, differ from Paul in three principle areas. Firstly, whereas Paul’s concept of transformation is based largely on objective realities, representatives of the Contemplative Tradition tend to focus on subjective realities. Secondly, contemporary contemplatives view transformation as coming as one imitates the life of Christ, his daily disciplines and activities, whereas Paul’s view centres on the death of Christ as foundational to the Christian’s identity and thus vital to the way they live out their faith. Finally, the cornerstone of the contemporary Contemplative Tradition’s view of spiritual transformation is the belief that the essential means by which transformation takes place is engagement in the spiritual disciplines. It is argued that many of the activities that are denominated as ‘spiritual disciplines’ are not in fact ‘transformative’ activities, and thus do not fit the category of spiritual disciplines. Furthermore, this study insists that Paul seldom links the practice of the disciplines with the means of transformation, offering instead five examples of specific means of transformation that flow out of Paul’s accepted letters.

  14. Contemplation, Subcreation, and Video Games

    Directory of Open Access Journals (Sweden)

    Mark J. P. Wolf

    2018-04-01

    Full Text Available This essay asks how religion and theological ideas might be made manifest in video games, and particularly the creation of video games as a religious activity, looking at contemplative experiences in video games, and the creation and world-building of game worlds as a form of Tolkienian subcreation, which itself leads to contemplation regarding the creation of worlds.

  15. Applying quranic contemplation in counseling

    Directory of Open Access Journals (Sweden)

    Daris Tamin

    2016-12-01

    Full Text Available The intent of this research project was to explore the use of Quranic contemplation practices in counseling. In Islamic terminology that mean Quranic contemplation known as Tadabbur Al-Quran. Referring to this objective, this research is on the continuum between basic research and applied research. The research method that has been applied mix method beetwen quantitative and qualitative approaches. Integrating the two methods were considered appropriate for pragmatism paradigm adopted in this research. Based on the results of the research found that: Quranic Contemplation in Counseling that applicable on four general phases, namely: Exploration, Reading Scripture, Developing, and Supplication. In particular, at each session consists of seven steps, namely: (1 build engagement counselee to open his/her heart to accept the Quran as a heart medicine, the instructions for the peace of mind and happiness in life; (2 exposing the problems of the counselee; (3 identify the norms adopted counselee; (4 guiding the counselee for contemplations with Quran in the order: recited, guiding understand the meaning of the verse, raised the focus on words related to the problem, the main message conveyed paragraph, reflecting the message of verses in everyday life; and expand the discussion; (5 made a commitment to change the behavior of current and future; (6 invited to join in the spiritual community; and (7 guided prayer.

  16. Contemplated Suicide Among Voluntary and Involuntary Retirees

    Science.gov (United States)

    Peretti, Peter O.; Wilson, Cedric

    1978-01-01

    This study explored anomic and egoistic dimensions of contemplated suicide among voluntary and involuntary retired males. Results indicated a direct relationship between anomie and egoism on the one hand, and contemplation of suicide on the other. (Author)

  17. The epidemiological Boehringer Ingelheim Employee study--part I: impact of overweight and obesity on cardiometabolic risk.

    Science.gov (United States)

    Kempf, Kerstin; Martin, Stephan; Döhring, Carmen; Dugi, Klaus; Wolfram von Wolmar, Carolin; Haastert, Burkhard; Schneider, Michael

    2013-01-01

    Obesity-dependent diseases cause economic burden to companies. Large-scale data for working populations are lacking. Prevalence of overweight and obesity in the Boehringer Ingelheim (BI) Employee cohort and the relationship between body mass index (BMI) and cardiometabolic risk factors and diseases were estimated. Employees (≥38 years, employed in Ingelheim ≥2 years; n = 3151) of BI Pharma GmbH & Co. KG were invited by the medical corporate department to participate in intensive health checkups. Cross-sectional analysis of baseline data collected through 2006-2011 was performed. 90% of eligible subjects participated (n = 2849). Prevalences of overweight and obesity were 40% and 18% and significantly higher in men and participants ≥50 years. Cardiometabolic risk factor levels and prevalences of cardiometabolic diseases significantly increased with BMI and were higher in overweight and obese participants. Cut-points for increased risk estimated from ROC curves were ≈ 25 kg/m(2) for hypertension, hypercholesterolemia, arteriosclerosis, and hypertriglyceridemia and 26.7-28.0 kg/m(2) for the metabolic syndrome, insulin resistance, hyperinsulinemia, increased intima media thickness, and type 2 diabetes. This is the first large-scale occupational health care cohort from a single company. Cardiometabolic risk factors and diseases accumulate with increasing BMI. Occupational weight reduction programs seem to be reasonable strategies.

  18. Contemplative Administration: Transforming the Workplace Culture of Higher Education

    Science.gov (United States)

    Beer, Laura E.

    2010-01-01

    A contemplative approach to higher education is receiving increased attention and application in the classroom. Applying contemplative practices to administration, however, has received little attention in the literature. This case study offers a unique look at Naropa University and its implementation of contemplative administration. Findings…

  19. Computer-aided drug design at Boehringer Ingelheim

    Science.gov (United States)

    Muegge, Ingo; Bergner, Andreas; Kriegl, Jan M.

    2017-03-01

    Computer-Aided Drug Design (CADD) is an integral part of the drug discovery endeavor at Boehringer Ingelheim (BI). CADD contributes to the evaluation of new therapeutic concepts, identifies small molecule starting points for drug discovery, and develops strategies for optimizing hit and lead compounds. The CADD scientists at BI benefit from the global use and development of both software platforms and computational services. A number of computational techniques developed in-house have significantly changed the way early drug discovery is carried out at BI. In particular, virtual screening in vast chemical spaces, which can be accessed by combinatorial chemistry, has added a new option for the identification of hits in many projects. Recently, a new framework has been implemented allowing fast, interactive predictions of relevant on and off target endpoints and other optimization parameters. In addition to the introduction of this new framework at BI, CADD has been focusing on the enablement of medicinal chemists to independently perform an increasing amount of molecular modeling and design work. This is made possible through the deployment of MOE as a global modeling platform, allowing computational and medicinal chemists to freely share ideas and modeling results. Furthermore, a central communication layer called the computational chemistry framework provides broad access to predictive models and other computational services.

  20. Contemplative interventions or cultures of awareness in school

    DEFF Research Database (Denmark)

    Nielsen, Anne Maj; Kolmos, Marie

    How do children experience contemplative activities in everyday school life? During the past decade there have been increased reports of stress and concentration problems among school children. Furthermore the everyday life of school children is conducted across diverse contexts that expose...... the children to various demands, opportunities and relations. According to the growing body of knowledge contemplative education and mindfulness in education can reduce stress and concentration problems for schoolchildren (i.e. Byrnes, 2012; Flook et al., 2010; Jennings et al., 2012; Napoli, 2004......). Contemplative education in this study conceptualizes the work with personal experiences of mindful sensuous activities related to the school subjects. We present and discuss results from a qualitative study of a school class (grade 5-6, children aged 11-13) through the initiation of contemplative practice...

  1. The Epidemiological Boehringer Ingelheim Employee Study—Part I: Impact of Overweight and Obesity on Cardiometabolic Risk

    Science.gov (United States)

    Martin, Stephan; Döhring, Carmen; Dugi, Klaus; Wolfram von Wolmar, Carolin; Haastert, Burkhard; Schneider, Michael

    2013-01-01

    Objective. Obesity-dependent diseases cause economic burden to companies. Large-scale data for working populations are lacking. Prevalence of overweight and obesity in the Boehringer Ingelheim (BI) Employee cohort and the relationship between body mass index (BMI) and cardiometabolic risk factors and diseases were estimated. Design and Methods. Employees (≥38 years, employed in Ingelheim ≥2 years; n = 3151) of BI Pharma GmbH & Co. KG were invited by the medical corporate department to participate in intensive health checkups. Cross-sectional analysis of baseline data collected through 2006–2011 was performed. Results. 90% of eligible subjects participated (n = 2849). Prevalences of overweight and obesity were 40% and 18% and significantly higher in men and participants ≥50 years. Cardiometabolic risk factor levels and prevalences of cardiometabolic diseases significantly increased with BMI and were higher in overweight and obese participants. Cut-points for increased risk estimated from ROC curves were ≈25 kg/m2 for hypertension, hypercholesterolemia, arteriosclerosis, and hypertriglyceridemia and 26.7–28.0 kg/m2 for the metabolic syndrome, insulin resistance, hyperinsulinemia, increased intima media thickness, and type 2 diabetes. Conclusion. This is the first large-scale occupational health care cohort from a single company. Cardiometabolic risk factors and diseases accumulate with increasing BMI. Occupational weight reduction programs seem to be reasonable strategies. PMID:23997947

  2. The Epidemiological Boehringer Ingelheim Employee Study—Part I: Impact of Overweight and Obesity on Cardiometabolic Risk

    Directory of Open Access Journals (Sweden)

    Kerstin Kempf

    2013-01-01

    Full Text Available Objective. Obesity-dependent diseases cause economic burden to companies. Large-scale data for working populations are lacking. Prevalence of overweight and obesity in the Boehringer Ingelheim (BI Employee cohort and the relationship between body mass index (BMI and cardiometabolic risk factors and diseases were estimated. Design and Methods. Employees (≥38 years, employed in Ingelheim ≥2 years; n=3151 of BI Pharma GmbH & Co. KG were invited by the medical corporate department to participate in intensive health checkups. Cross-sectional analysis of baseline data collected through 2006–2011 was performed. Results. 90% of eligible subjects participated (n=2849. Prevalences of overweight and obesity were 40% and 18% and significantly higher in men and participants ≥50 years. Cardiometabolic risk factor levels and prevalences of cardiometabolic diseases significantly increased with BMI and were higher in overweight and obese participants. Cut-points for increased risk estimated from ROC curves were ≈25 kg/m2 for hypertension, hypercholesterolemia, arteriosclerosis, and hypertriglyceridemia and 26.7–28.0 kg/m2 for the metabolic syndrome, insulin resistance, hyperinsulinemia, increased intima media thickness, and type 2 diabetes. Conclusion. This is the first large-scale occupational health care cohort from a single company. Cardiometabolic risk factors and diseases accumulate with increasing BMI. Occupational weight reduction programs seem to be reasonable strategies.

  3. Contemplative Neuroscience as an Approach to Volitional Consciousness

    Science.gov (United States)

    Thompson, Evan

    This chapter presents a methodological approach to volitional consciousness for cognitive neuroscience based on studying the voluntary self-generation and self-regulation of mental states in meditation. Called contemplative neuroscience, this approach views attention, awareness, and emotion regulation as flexible and trainable skills, and works with experimental participants who have undergone training in contemplative practices designed to hone these skills. Drawing from research on the dynamical neural correlates of contemplative mental states and theories of large-scale neural coordination dynamics, I argue for the importance of global system causation in brain activity and present an "interventionist" approach to intentional causation.

  4. Intuitive Versus Contemplative

    DEFF Research Database (Denmark)

    Koudstaal, Martin; Sloof, Randolph; Van Praag, Mirjam

    We examine in a large survey (n = 1,928) how contemplative entrepreneurs, managers and employees are in their decision making styles. Besides two well-known subjective measures taken from psychology, we also build on Rubinstein (2016) by including two objective measures derived from response time......, but at the same time share with managers a higher need for cognition, and thus take more time to think things over....

  5. Contemplation: If It Makes for Peace, Why Not for Christian Witness Too?

    Directory of Open Access Journals (Sweden)

    Pawel Tarasiewicz

    2017-03-01

    Full Text Available The author attempts to answer the following question: Why does Christian witness need contemplation? He claims that Christian witness needs contemplation, because contemplation reveals the truth about the nature of reality; it is this truth which is one of the factors that constitute the foundation of Christian faith. In a sense, contemplation is analogical to mysticism: as mystical visions make Christian belief grounded on the immediate experience of (meeting with the Truth, so the contemplation of the creatures makes Christian belief based on the indirect experience of the Truth (i.e., the meeting with the traces left by the Creator in the world.

  6. A Brief History of the Current Reemergence of Contemplative Education

    Science.gov (United States)

    Morgan, Patricia Fay

    2015-01-01

    This article explores the history of the current reemergence of a contemplative orientation in education. While referencing an ancient history, it primarily examines the history of contemporary contemplative education through three significant stages, focusing on the third. The first was arguably initiated by the introduction of Buddhism to the…

  7. Ballet as a movement-based contemplative practice? Implications for neuroscientific studies

    NARCIS (Netherlands)

    van Vugt, Marieke

    2014-01-01

    There is a rising scientific interest in the neuroscience behind contemplative practices (see e.g., Vago and Silbersweig, 2012 for a review), including movement-based practices such as yoga and tai chi. Given that, it becomes important to ask how such contemplative practices differ from Western

  8. Brief Contemplation as a Factor in the Accuracy of Perceptual Judgments.

    Science.gov (United States)

    Rollman, Steven A.; Gabbard-Alley, Anne

    A study investigated the importance of brief contemplation as a factor in the accuracy of judgments about other people, based on their nonverbal appearance. The following questions were addressed: (1) Are observers who are given time to contemplate the significance of nonverbal cues more accurate in their perceptual judgments than observers who…

  9. Reflexive awareness, transcendence and witnessing - in contemplative awareness cultures in school

    DEFF Research Database (Denmark)

    Nielsen, Anne Maj

    The paper presents reflections about contemplative education as a way to learn openness and witnessing phenomena of the mind and of lived experiences of oneself and others. The reflections include concepts of transcendence and witnessing and results from a qualitative study of contemplative educa...... and to adopt an open and reflective self-perception and understanding of others....

  10. Meditation and Dance in Creative Society: Contemplative Consciousness in Daoism, Zen and Argentine Tango

    Directory of Open Access Journals (Sweden)

    Agnieška Juzefovič

    2015-07-01

    Full Text Available This paper deals with the particularly relevant topic in the contemporary society – Asian meditative practices and methods of self-development. The first chapter deals with the notion of contemplative, enlightened consciousness in Daoism and Zen. The second chapter shows how meditative consciousness could be achieved through social tango. Six theses are argued as appropriate for both Daoism and Zen as well as tango: 1 contemplative, purified consciousness is empty of disturbing thoughts and focused toward the essence; 2 contemplative, purified consciousness is not only empty but also brimming full; 3 contemplative, purified consciousness is identical with everyday mind; 4 contemplative mind is functioning according to the principles of non-action and naturalness; 5 meditation leads toward the unity and integrity of consciousness and body, consciousness and outside world; 6 active meditation is an effective way to obtain aims mentioned above. The argumentation of such thesis helps to show that tango is akin to various meditative practices. So it could not only be successfully used as a form of entertainment but also as a meditative practice, leading toward aims, similar to those of Zen meditations.

  11. Contemplation as a Corrective to Technological Education

    Science.gov (United States)

    Steel, Sean

    2013-01-01

    This paper argues that noetic studies, contemplation, or "theoria" ought to take greater precedence in education than is currently the case. Our modern focus on and fascination with information technologies serves in many ways to thwart and to discourage the cultivation of noetic studies and the pursuit of wisdom in schools. The…

  12. Contemplating the Future: Building Student Resilience in Climate Change Education

    Science.gov (United States)

    Allison, E.

    2015-12-01

    Climate change research has largely focused on the biophysical, economic, and political aspects of the phenomenon, its projected impacts, and the possibilities for adaptation (Carey et al. 2014; Castree et al. 2014). In the classroom, too, climate change is generally presented as a scientific, technological, political, and economic challenge. However, defining climate change as physical challenge, divorced from its cultural causes and responses, forecloses some pathways of inquiry and limits the possibilities for adaptation (Adger et al. 2013). Recent perspectives by the environmental historian Mark Carey and colleagues (2014) and by the geographer Noel Castree and colleagues (2014) contend that ethnographic, narrative, social scientific, and humanistic insights are necessary additions to the climate change policy process and can contribute to deliberate, resilient responses to climate change. Among the humanistic insights needed are strategies and practices to maintain fortitude and persistence in the midst of dispiriting ecological trends. Students facing the "gloom and doom" of climate change data in environmental studies courses can experience negative states of mind such as denial, despair, burnout, and grief. Emerging research, however, demonstrates how contemplative practice can shift consciousness and promote resilience. Contemplative practices are those that consciously direct calm, focused attention. Such practices can build internal resilience, by promoting a greater sense of calm and well-being, decreasing stress, and sharpening focus and concentration. In addition, contemplative practices improve relationships with other people, through increasing compassion and flexibility in thinking. They also strengthen relationships with the surrounding world by increasing our ability to question, explore, and cope with rapid change and complexity. This presentation provides a context for incorporating contemplative practices, including mindfulness exercises

  13. Meditation and the Classroom: Contemplative Pedagogy for Religious Studies. SUNY Series in Religious Studies

    Science.gov (United States)

    Simmer-Brown, Judith, Ed.; Grace, Fran, Ed.

    2011-01-01

    "Meditation and the Classroom" inventively articulates how educators can use meditation to educate the whole student. Notably, a number of universities have initiated contemplative studies options and others have opened contemplative spaces. This represents an attempt to address the inner life. It is also a sign of a new era, one in…

  14. Getting to why? Contemplative practice as reflection on intentionality

    African Journals Online (AJOL)

    2015-08-31

    Aug 31, 2015 ... reflection may be facilitated by contemplative practices such as mindfulness and ... something else, liked, disliked, or called good or bad by the phantom self, the ego. ..... meta-cognition, and finally the release of attentional.

  15. System contemplations for precision irrigation in agriculture

    Science.gov (United States)

    Schubert, Martin J. W.

    2017-04-01

    This communication contemplates political, biological and technical aspects for efficient and profitable irrigation in sustainable agriculture. A standard for irrigation components is proposed. The need for many, and three-dimensionally distributed, soil measurement points is explained, thus enabling the control of humidity in selected layers of earth. Combined wireless and wired data transmission is proposed. Energy harvesting and storage together with mechanical sensor construction are discussed.

  16. Integrating Contemplative Tools into Biomedical Science Education and Research Training Programs

    Directory of Open Access Journals (Sweden)

    Rodney R. Dietert

    2014-01-01

    Full Text Available Academic preparation of science researchers and/or human or veterinary medicine clinicians through the science, technology, engineering, and mathematics (STEM curriculum has usually focused on the students (1 acquiring increased disciplinary expertise, (2 learning needed methodologies and protocols, and (3 expanding their capacity for intense, persistent focus. Such educational training is effective until roadblocks or problems arise via this highly-learned approach. Then, the health science trainee may have few tools available for effective problem solving. Training to achieve flexibility, adaptability, and broadened perspectives using contemplative practices has been rare among biomedical education programs. To address this gap, a Cornell University-based program involving formal biomedical science coursework, and health science workshops has been developed to offer science students, researchers and health professionals a broader array of personal, contemplation-based, problem-solving tools. This STEM educational initiative includes first-person exercises designed to broaden perceptional awareness, decrease emotional drama, and mobilize whole-body strategies for creative problem solving. Self-calibration and journaling are used for students to evaluate the personal utility of each exercise. The educational goals are to increase student self-awareness and self-regulation and to provide trainees with value-added tools for career-long problem solving. Basic elements of this educational initiative are discussed using the framework of the Tree of Contemplative Practices.

  17. Mindfulness in Art Contemplation. The Story of a Rothko Experience

    Science.gov (United States)

    Echarri, Fernando; Urpi, Carmen

    2018-01-01

    The nature and scope of the experiences offered to museum visitors are varied and changing, given that museums make it possible to explore new methodologies for unleashing and transmitting meaning during visits. In this regard, at the University of Navarra Museum, we researched the possibilities for mindfulness as a contemplative technique to…

  18. Art Therapy and Its Contemplative Nature: Unifying Aspects of Image Making

    Science.gov (United States)

    Salom, Andrée

    2013-01-01

    This article describes an art-based inquiry that explored two contemplative strategies--the conceptual strategy and the awareness strategy--through observation of art images and processes of creation, conceptual understanding, assessment, and the inner movements of self-awareness. Art media and directives were used to subjectively test key…

  19. Contemplative/emotion training reduces negative emotional behavior and promotes prosocial responses.

    Science.gov (United States)

    Kemeny, Margaret E; Foltz, Carol; Cavanagh, James F; Cullen, Margaret; Giese-Davis, Janine; Jennings, Patricia; Rosenberg, Erika L; Gillath, Omri; Shaver, Phillip R; Wallace, B Alan; Ekman, Paul

    2012-04-01

    Contemplative practices are believed to alleviate psychological problems, cultivate prosocial behavior and promote self-awareness. In addition, psychological science has developed tools and models for understanding the mind and promoting well-being. Additional effort is needed to combine frameworks and techniques from these traditions to improve emotional experience and socioemotional behavior. An 8-week intensive (42 hr) meditation/emotion regulation training intervention was designed by experts in contemplative traditions and emotion science to reduce "destructive enactment of emotions" and enhance prosocial responses. Participants were 82 healthy female schoolteachers who were randomly assigned to a training group or a wait-list control group, and assessed preassessment, postassessment, and 5 months after training completion. Assessments included self-reports and experimental tasks to capture changes in emotional behavior. The training group reported reduced trait negative affect, rumination, depression, and anxiety, and increased trait positive affect and mindfulness compared to the control group. On a series of behavioral tasks, the training increased recognition of emotions in others (Micro-Expression Training Tool), protected trainees from some of the psychophysiological effects of an experimental threat to self (Trier Social Stress Test; TSST), appeared to activate cognitive networks associated with compassion (lexical decision procedure), and affected hostile behavior in the Marital Interaction Task. Most effects at postassessment that were examined at follow-up were maintained (excluding positive affect, TSST rumination, and respiratory sinus arrhythmia recovery). Findings suggest that increased awareness of mental processes can influence emotional behavior, and they support the benefit of integrating contemplative theories/practices with psychological models and methods of emotion regulation. (PsycINFO Database Record (c) 2012 APA, all rights reserved).

  20. Reading Sara Pujol Russell’s Poetry of Contemplation and Connection

    Directory of Open Access Journals (Sweden)

    Anita M. Hart

    2012-06-01

    Full Text Available Sara Pujol Russell’s poetry captures a process of expanding consciousness and personal renewal. Through contemplation and attention to nature, the poet-speaker in her works generates a sense of connection that moves her beyond daily concerns. Pujol’s poetry is both metaphysical and also different in that it resists easy classification and is not representative of mainstream trends. This essay approaches the distinctiveness of Pujol’s work by studying selected poems from her third book of poetry in Spanish, Para decir sí a la carencia, sí a la naranja, al azafrán en el pan (2004 ‘To Say Yes to Lack, Yes to the Orange, to the Saffron in the Bread.’ Incorporating philosopher María Zambrano’s thoughts on contemplation, it shows Pujol’s poet-speaker establishing a connection with nature and spirit, experiencing a heightened consciousness, and searching for expression. The poetic language is characterized by vision, intimacy, enigma, and contradiction. In its subjective, intuitive way, Pujol’s work reveals the poet-speaker’s winding path of discovery and challenges the reader to look closely inside and outside in engaging life’s mysteries.

  1. The Boehringer Ingelheim employee study (Part 2): 10-year cardiovascular diseases risk estimation.

    Science.gov (United States)

    Kempf, K; Martin, S; Döhring, C; Dugi, K; Haastert, B; Schneider, M

    2016-10-01

    Cardiovascular disease (CVD) may cause an economic burden to companies, but CVD risk estimations specific to working populations are lacking. To estimate the 10-year CVD risk in the Boehringer Ingelheim (BI) employee cohort and analyse the potential effect of hypothetical risk reduction interventions. We estimated CVD risk using the Framingham (FRS), PROCAM (PRS) and Reynolds (RRS) risk scores, using cross-sectional baseline data on BI Pharma employees collected from 2005 to 2011. Results were compared using Fisher's exact and Wilcoxon tests. The predictive ability of the score estimates was assessed using receiver-operating characteristics analyses. Among the 4005 study subjects, we estimated 10-year CVD risks of 35% (FRS), 9% (PRS) and 6% (RRS) for men and 10% (FRS), 4% (PRS) and 1% (RRS) for women. One hundred and thirty-four (6%) men and 111 (6%) women employees had current CVD. The best predictors of prevalent CVD were the FRS and the RRS for men [area-under-the-curve 0.62 (0.57-0.67) for both]. A hypothetical intervention that would improve systolic blood pressure, HbA1c (for diabetes), C-reactive protein, triglycerides and total and high-density lipoprotein cholesterol by 10% each would potentially reduce expected CVD cases by 36-41% in men and 30-45% in women, and if smoking cessation is incorporated, by 39-45% and 30-55%, respectively, depending on the pre-intervention risk score. There was a substantial risk of developing CVD in this working cohort. Occupational health programmes with lifestyle interventions for high-risk individuals may be an effective risk reduction measure. © The Author 2016. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  2. Relation between contemplative exercises and an enriched psychology students' experience in a neuroscience course

    Science.gov (United States)

    Levit Binnun, Nava; Tarrasch, Ricardo

    2014-01-01

    This article examines the relation of contemplative exercises with enhancement of students' experience during neuroscience studies. Short contemplative exercises inspired by the Buddhist tradition of self-inquiry were introduced in an undergraduate neuroscience course for psychology students. At the start of the class, all students were asked to participate in short “personal brain investigations” relevant to the topic presented. These investigations were aimed at bringing stable awareness to a specific perceptual, emotional, attentional, or cognitive process and observing it in a non-judgmental, non-personal way. In addition, students could choose to participate, for bonus credit, in a longer exercise designed to expand upon the weekly class activity. In the exercise, students continued their “personal brain investigations” for 10 min a day, 4 days a week. They wrote “lab reports” on their daily observations, obtained feedback from the teacher, and at the end of the year reviewed their reports and reflected upon their experiences during the semester. Out of 265 students, 102 students completed the bonus track and their final reflections were analyzed using qualitative methodology. In addition, 91 of the students answered a survey at the end of the course, 43 students participated in a quiz 1 year after course graduation, and the final grades of all students were collected and analyzed. Overall, students reported satisfaction from the exercises and felt they contributed to their learning experience. In the 1-year follow-up, the bonus-track students were significantly more likely than their peers to remember class material. The qualitative analysis of bonus-track students' reports revealed that the bonus-track process elicited positive feelings, helped students connect with class material and provided them with personal insights. In addition, students acquired contemplative skills, such as increased awareness and attention, non-judgmental attitudes, and

  3. Effect of Contemplative Pedagogy on the Ecoliteracy of Undergraduate Public State University Students

    Science.gov (United States)

    Lees, Michael

    2017-01-01

    Undergraduate students lack the opportunity and environment to contemplate and develop ecoliteracy skills that serve to integrate subject matter into their everyday experiences. Ecoliteracy is grounded in Capra's web of life theoretical framework and represents students' capacities to read world systems objectively with their head, heart, hands,…

  4. Contemplative Practices in Early Childhood: Implications for Self-Regulation Skills and School Readiness

    Science.gov (United States)

    Willis, Elizabeth; Dinehart, Laura H.

    2014-01-01

    This article examines the development of self-regulation skills in early childhood and the possibilities of children's contemplative practices as a viable tool to facilitate this development. Current research indicates that self-regulation skills in early childhood education make a significant contribution to school readiness, and long-term…

  5. Preconception counselling initiated by general practitioners in the Netherlands: reaching couples contemplating pregnancy [ISRCTN53942912

    Directory of Open Access Journals (Sweden)

    Verloove-Vanhorick SP

    2006-07-01

    Full Text Available Abstract Background To maximise the potential for reducing the risk of adverse pregnancy outcomes, preconception counselling (PCC is used to inform couples contemplating pregnancy about general and personal risk factors. Many initiatives have been developed to provide PCC, but none offers it routinely in a presumed low-risk population. The objective of the study was to investigate the extent to which women contemplating pregnancy can be reached when a PCC programme is routinely offered by general practitioners (GPs. Methods 30 GPs actively offered PCC to all women aged 18 to 40 over a three-year period. GPs reviewed lists of these women and excluded women with adverse social circumstances. The remaining women received an invitation for PCC. They were requested to indicate whether they were interested in PCC, and if so, when they were contemplating pregnancy. Those both interested and contemplating pregnancy within one year were invited for PCC. All pregnancies occurring within one year of an invitation were monitored. Response rates and percentages of pregnancies preceded by an invitation or actual attendance to PCC were calculated. Results Overall, 72–75% of the interested responders, who returned the risk-assessment questionnaire (80%, actually attended PCC. However, the GPs excluded a large number of women. In 2002 27% of all pregnancies occurred in the group of women who had been interested and had indicated that they hoped to get pregnant within one year. Another 33% of the pregnancies occurred in the group of women who had been excluded, 13% in the group who had not responded, and 14% in the group who had not been interested. Conclusion A quarter of the women who became pregnant in the year after the invitation were reached in time. In order to increase this number, methods should be developed to decrease the exclusion of women by the GPs and to increase women's response.

  6. Contemplating and Extending the Scholarship on Children's and Young Adult Literature

    Science.gov (United States)

    Brooks, Wanda; Cueto, Desiree

    2018-01-01

    To commemorate the 50th anniversary of the "Journal of Literacy Research," this article reviews the trajectory of a particular line of scholarship published in this journal over the past five decades. We focus on African diaspora youth literature to contemplate and extend the ways in which literacy researchers carry out textual analysis…

  7. Developing Public Mind Curriculum for Lower Secondary School Classes Using Contemplative Education Methods

    Science.gov (United States)

    Srijumnong, Sirithorn; Sri-ampai, Pissamai; Chano, Jiraporn

    2015-01-01

    The purposes of this study were to develop a public mind curriculum with Contemplative Education and to study the effect of using the curriculum to enhance public minds. The study was carried out using the research and development process, consisting of three phases: investigating fundamental data, developing a curriculum, and evaluating the…

  8. Brief quiet ego contemplation reduces oxidative stress and mind-wandering

    Directory of Open Access Journals (Sweden)

    Heidi A. Wayment

    2015-09-01

    Full Text Available Excessive self-concern increases perceptions of threat and defensiveness. In contrast, fostering a more inclusive and expanded sense of self can reduce stress and improve well-being. We developed and tested a novel brief intervention designed to strengthen a student’s compassionate self-identity, an identity that values balance and growth by reminding them of four quiet ego characteristics: detached awareness, inclusive identity, perspective taking, and growth. Students (N = 32 in their first semester of college who reported greater self-protective (e.g., defensive goals in the first two weeks of the semester were invited to participate in the study. Volunteers were randomly assigned to one of three conditions: quiet ego contemplation (QEC, QEC with virtual reality headset (QEC-VR, and control. Participants came to the lab three times to engage in a 15-minute exercise in a 30-day period. The 15-minute Quiet Ego Contemplation (QEC briefly described each quiet ego characteristic followed by a few minutes time to reflect on what that characteristic meant to them. Those in the QEC condition reported improved quiet ego characteristics and pluralistic thinking, decreases in a urinary marker of oxidative stress, and reduced mind-wandering on a cognitive task. Contrary to expectation, participants who wore the VR headsets while listening to the QEC demonstrated the least improvement. Results suggest that a brief intervention that reduces self-focus and strengthens a more compassionate self-view may offer an additional resource that individuals can use in their everyday lives.

  9. Integrating Brain Science into Health Studies: An Interdisciplinary Course in Contemplative Neuroscience and Yoga

    Science.gov (United States)

    Wolfe, Uta; Moran, Amy

    2017-01-01

    As neuroscience knowledge grows in its scope of societal applications so does the need to educate a wider audience on how to critically evaluate its research findings. Efforts at finding teaching approaches that are interdisciplinary, accessible and highly applicable to student experience are thus ongoing. The article describes an interdisciplinary undergraduate health course that combines the academic study of contemplative neuroscience with contemplative practice, specifically yoga. The class aims to reach a diverse mix of students by teaching applicable, health-relevant neuroscience material while directly connecting it to first-hand experience. Outcomes indicate success on these goals: The course attracted a wide range of students, including nearly 50% non-science majors. On a pre/post test, students showed large increases in their knowledge of neuroscience. Students’ ratings of the course overall, of increases in positive feelings about its field, and of their progress on specific course objectives were highly positive. Finally, students in their written work applied neuroscience course content to their personal and professional lives. Such results indicate that this approach could serve as a model for the interdisciplinary, accessible and applied integration of relevant neuroscience material into the undergraduate health curriculum. PMID:29371845

  10. Strange Bedfellows: Meditations on the Indispensable Virtues of Confusion, Mindfulness and Humor in the Neuroscientific and Cognitive Study of Esoteric and Contemplative Traditions1

    Directory of Open Access Journals (Sweden)

    Jeffrey C. Ruff

    2016-09-01

    Full Text Available Several recent publications in the study of esoteric traditions have drawn together insights from scholars of religions and philosophy, contemplative communities, metaphor and conceptual blend theories, cognitive sciences, neurosciences, and physical anthropology. These interdisciplinary explorations revolve around contemplative practices (meditation, mindfulness, ritual traditions, etc.. This includes both ethnographic and textual expressions of these traditions. This paper is a response to the questions and insights of some recent articles, books, and two 2015 conference papers, with the specific purpose of contributing to what Glen Hayes (2014 called “the need to develop and ‘new vocabulary’ for this interdisciplinary study” of contemplative and esoteric traditions (Hayes’ call was specifically in reference to Hindu Tantra. To do this, I have referred to some other scientific approaches to which the scholars of esoteric and contemplative communities have not made much mention, and then to offer a form of reflection and meditation on what this new vocabulary and these research projects call us to do: their concepts, logic, and meaning. To this end, I have given some careful attention to the concepts of confusion, mindfulness, humor, and dispassionate vulnerability to help us better understand what we are doing, and where we should go from here.

  11. Gratitude contemplation as a method to improve human well-being and physical functioning: theoretical review of existing research

    Directory of Open Access Journals (Sweden)

    Bożena Burzyńska

    2018-03-01

    Full Text Available Research in positive psychology aims to find and develop diverse ways to improve human well-being and the psychophysical functioning (Fredrickson, 2008; Seligman, 2002; Sheldon & Lyubomirsky, 2006. As an example, the studies regard such concepts as positive emotions, character strengths or meaning in life. One of the most frequently studied constructs is also gratitude, that is regarded as the appreciation of all what is meaningful, as well as valuable, to oneself (Sansone & Sansone, 2010. Also, the social aspect of being grateful, and the effects of gratitude on one’s health and physical functioning, are frequently emphasized (McCullough, Kimeldorf & Cohen, 2008; Fox, Kaplan, Damasio and Damasio 2015; Algoe, Haidt & Gable, 2008. Among great amount of work about general gratitude already, there is still little research about gratitude contemplation, one of the exercises that enable a person experiencing gratitude in form of meditation. In this article, first I explain the meaning of the gratitude construct and its impact on peoples psychophysical state in general. Then, I analyze one of the newest gratitude activity, that is gratitude contemplation, its definition, the way of use and the results of recent empirical studies worldwide. Finally, I critically discuss the findings and conclude with future steps for further research on gratitude contemplation. I believe that the results and analysis presented in the article create a base for further research in the area of positive psychology.

  12. CONTEMPLATIVE POSITIVE PSYCHOLOGY: INTRODUCING MINDFULNESS INTO POSITIVE PSYCHOLOGY

    Directory of Open Access Journals (Sweden)

    Ausiàs Cebolla

    2017-01-01

    Full Text Available Although mindfulness is included in many positive psychology manuals as a “positive” technique, the implications of its use have scarcely been developed and the relationship between mindfulness and human well-being has barely been researched. Analyzing the main strengths of the two fields, the possibilities for their integration and the potential contradictions between their messages is essential in order to establish connections. Mindfulness is more than a meditation technique. It has implicit within it a set of values and ethical conditions that coincide to a great extent with the proposed assumptions from positive psychology, such as the development of kindness, compassion, and positive emotions. The aim of this paper is to present, on the one hand, the commonalities and similarities, and on the other, the differences between mindfulness and positive psychology. We also present the main studies that have investigated the role of mindfulness and contemplative practices on human well-being. Finally future research will be discussed and intervention suggested in order to bring the two proposals together.

  13. 76 FR 72976 - Manufacturer of Controlled Substances; Notice of Registration

    Science.gov (United States)

    2011-11-28

    ..., 2011, 76 FR 36577, Boehringer Ingelheim Chemicals, Inc., 2820 N. Normandy Drive, Petersburg, Virginia... Boehringer Ingelheim Chemicals, Inc., to manufacture the listed basic classes of controlled substances is consistent with the public interest at this time. DEA has investigated Boehringer Ingelheim Chemicals, Inc...

  14. Risky procedures by nurses in hospitals: problems and (contemplated) refusals of orders by physicians, and views of physicians and nurses

    NARCIS (Netherlands)

    de Bie, J.; Cuperus-Bosma, J.M.; van der Jagt, M.A.; Gevers, J.K.M.; van der Wal, G.

    2005-01-01

    Occurrence of problems with, refusals of orders and contemplated refusals of orders for risky procedures by nurses in Dutch hospitals and views on the safety of performance was studied using postal questionnaires (600 physicians and 3200 nurses, response 60-71%). Of the respondents, 11-30%

  15. 2 obras de F. J. Barba Corsini: Edificio de los Laboratorios Boehringer Sohn Ingelheim, S. A. B., en San Juan Despí, Barcelona; Cine Victoria, en Hospitalet de Llobregat

    Directory of Open Access Journals (Sweden)

    Barba Corsini, F. J.

    1967-11-01

    Full Text Available Building for the Boehringer Sohn Ingelheim, S. A. E. Laboratories, at San Juan Despí – Barcelona The semibasement houses the services, including dressing rooms, dining hall, central air conditioning, stores, and other technical services. The ground floor comprises the main entrance hall and also some of the laboratories, whilst the rest of the building is mostly devoted to the functional purpose of the firm, i. e., laboratory work. The manager's office and council chamber are located on the second floor. The external aspect of the building reflects its function and is an outstanding example of impressive simplicity. Victoria Cinema, at Hospitalet de Llobregat – Barcelona The design of the building takes specifically into account the poor features of the site, the greater cost efficiency of reinforced concrete and the saving in construction time associated with metallic construction. Hence a compound design was adopted. All the external walls are built with unfaced brick, and «Durisol» has been adopted for the ceilings. The choice of illumination and colouring give the walls a fine quality, and emphasize their plastic texture. A restful quality and an indication of its commercial purpose are the fundamental features reflected by the external aspect of the building.Edificio de los Laboratorios Boehringer Sohn Ingelheim, S. A. E., en San Juan Despí- Barcelona La planta semisótano del edificio está dedicada a servicios: vestuario, comedor, central de acondicionamiento de aire, almacenes de utillaje, y servicios técnicos en general. En la planta baja se ha dispuesto el vestíbulo principal de acceso; y tanto en el resto de esta planta como en las superiores, se desarrollan todas las funciones de laboratorios. En la planta segunda se han instalado los despachos de Dirección, Sala de Juntas, etc. La expresión arquitectónica exterior del edificio responde a su utilidad y resalta por su elegante sencillez. Cine Victoria, en Hospitalet de

  16. 76 FR 62448 - Importer of Controlled Substances, Notice of Registration

    Science.gov (United States)

    2011-10-07

    ..., Boehringer Ingelheim Chemicals, Inc., 2820 N. Normandy Drive, Petersburg, Virginia 23805, made application by... Boehringer Ingelheim Chemicals, Inc. to import the basic class of controlled [[Page 62449

  17. Adults Contemplating University Study at a Distance: Issues, themes and concerns

    Directory of Open Access Journals (Sweden)

    Chris Morgan

    2003-04-01

    Full Text Available This study identifies and explores a range of themes, issues and questions that commonly confront adults contemplating enrolment in university, and why they persist. The study focuses particularly on issues facing prospective adult distance education learners. From a range of interviews, six themes were identified including fears, motivation, support from home, academic preparedness, suitability of programs, and identity change.It is argued that the more effective we become at information provision, guidance and preparation of adult pre-entry open and distance learners, the more likely students will experience a smooth transition to study, thus improving both student satisfaction and retention rates. Successful intervention with prospective distance education learners at this early point should aim to assist the process of informed decision making, which could result equally in an individual deciding not to pursue university study. The findings in this study should be particularly useful for those academics, course advisors, student counsellors, teachers in preparatory programs, and university information and support officers, and others who provide adult distance students, with pre-enrolment information and advice.

  18. Risky procedures by nurses in hospitals: problems and (contemplated) refusals of orders by physicians, and views of physicians and nurses: a questionnaire survey

    NARCIS (Netherlands)

    de Bie, J.; Cuperus-Bosma, J.M.; van der Jagt, M.A.; Gevers, J.K.M.; van der Wal, G.

    2005-01-01

    Occurrence of problems with, refusals of orders and contemplated refusals of orders for risky procedures by nurses in Dutch hospitals and views on the safety of performance was studied using postal questionnaires (600 physicians and 3200 nurses, response 60-71%). Of the respondents, 11-30%

  19. Evaluation of possible interaction among drugs contemplated for use during manned space flights

    Science.gov (United States)

    1973-01-01

    Possible interactions among drugs contemplated for use during manned spaceflights have been studied in several animal species. The following seven drugs were investigated: nitrofurantoin, chloral hydrate, hexobarbital, phenobarbital, flurazepam, diphenoxylate, and phenazopyridine. Particular combinations included: chloral hydrate, hexabarbital or flurazepam with nitrofurantoin; phenobarbital or flurazepam with phenazopyridine; and diphenoxylate with two does formulations of nitrofurantoin. Studies were carried out in several species to determine whether induction of liver microsomal enzymes would increase the tendency of phenazopyridine to produce methemoglobin in vivo. Animals were premedicated with phenobarbital, a known inducer of azoreductase, and in a separate experiment with flurazepam, before administration of phenazopyridine. Methemoglobin production was determined in each animal after receiving phenazopyridine. No evidence was found for increased production of methemoglobin in the rat, dog, or rabbit that could be attributed to increased amounts of microsomal enzymes.

  20. Forum on Jerrold Levinson, "Contemplating Art"

    Directory of Open Access Journals (Sweden)

    ed. by M. Rotili, with J. Levinson, A. Bertinetto, M. Di Monte, F. Focosi, L. Giombini

    2014-12-01

    Full Text Available Jerrold Levinson’s Contemplating Art provides the readers with a variety of heterogeneous topics and issues. The discussants who took part in the Forum about Levinson’s book chose four different “tracks” dealt with, offering four different reflections. The main topics of the debate are: music, historicity, aesthetic properties and aesthetic contextualism.Starting on the fact that music is one of the main fields of Contamplating Art Alessandro Bertinetto focus his paper on the ‘musical’ chapters of the book that 1 defend the theory of musical expressivity presented by Levinson in his previous books (the ‘theory of musical persona’; 2. articulate it in reference to particular aspects of musical experience, and 3. examine its contribution for the understanding of the narrative and dramatic dimension of music as well as 4., in general, for its artistic value. Michele Di Monte’s aim is to focus on the questions raised by the alleged essential historicality of the concept of art and the formal definition of the concept itself. He discusses, in particular, the epistemic basis and status of what Levinson calls ‘our present concept of art’, the logical outcomes of its role in defining and identifying the art of the past and the problematic relationship between a universality requirement and the theory’s pretension to historicality. Filippo Focosi discusses in the first place the passages of Levinson’s book where his paradigmatic aesthetic principle explicitly occurs; secondly, he shows how such a principle, as is there articulated, can disclose interest perspectives on other aspects of Levinson’s theories about art and aesthetic properties. The paper by Lisa Giombini focuses on on the role of context in Levinson’s definition of art.Afterdefining Levinson’s version of aesthetic contextualism, Giombiniunderlines how Levinson’s intentional-historical definition may provide fertile ground for a peculiar form of contextualism

  1. 76 FR 49649 - Oral Dosage Form New Animal Drugs; Change of Sponsor; Chlortetracycline; Sulfamethazine

    Science.gov (United States)

    2011-08-11

    ... of Pfizer, Inc., to Boehringer Ingelheim Vetmedica, Inc. DATES: This rule is effective August 11...-018, 055-039, 065-071, and 065-440) to Boehringer Ingelheim Vetmedica, Inc., 2621 North Belt Highway...

  2. The Dark Night of the Soul: causes and resolution of emotional distress among contemplative nuns.

    Science.gov (United States)

    Durà-Vilà, Glòria; Dein, Simon; Littlewood, Roland; Leavey, Gerard

    2010-09-01

    An ethnographic study was conducted in the Spanish Monastery of Santa Mónica whose community consists of ten contemplative Augustinian nuns. Through participant observation and interviews the stresses encountered by the nuns and the coping strategies they deployed are explored in depth. It was found that symptoms that otherwise might have been described as evidence of a depressive episode were understood by the nuns within the framework of the so-called Dark Night of the Soul narrative: an active process of transforming emotional distress into a process of self-reflection, attribution of religious meaning and spiritual growth. We conclude by discussing the clinical implications of this religious narrative, highlighting the importance of incorporating existential issues into clinical practice.

  3. 75 FR 69462 - Importer of Controlled Substances; Notice of Registration

    Science.gov (United States)

    2010-11-12

    ... 36683), Boehringer Ingelheim Chemicals, Inc., 2820 N. Normandy Drive, Petersburg, Virginia 23805, made... registration of Boehringer Ingelheim Chemicals, Inc. to import the basic class of controlled substance is..., conventions, or protocols in effect on [[Page 69463

  4. A Contemplation on ‘Sultana’s Dream’

    Directory of Open Access Journals (Sweden)

    Miss Priyanka Chakrabarty

    2014-06-01

    Full Text Available Sultana’s Dream is a piece written by the most prolific Muslim woman intellectual Begum Rokeya Shekhawat, published in the Ladies Magazine in 1905, from Madras. She spoke against patriarchy in Muslim community. Her Sultana’s Dream depicts a dream sequence but it is not simply a sequence for entertainment. It rather speaks for a transformation in society to bring women out of the boundaries of four walls of home and to work in the public sphere without interference of men at all. Through a dream, she challenges the dogmas, associated with Muslim women. Her own life is an example of many such practices, like confinement in a jenana system, etc. This piece attempts to review as to how beautifully the text is written and how radically forceful it is that encourages the readers to think of the degraded condition of women and how women particularly, never question the same. She brings about certain unbelievable sequences of those days through her writing. At that time, women’s education itself was a taboo. However, some consensus were developed by the reformers in both Hindu and Muslim communities—for them education for women was essential so that she become a good companion for her husband and a good mother. An idea that women need education for her individual growth was very rare. In spite of living and growing in such a society, it is contemplative as to how Begum Rokeya Shekhawat could manage to be so radical in her thoughts to challenge the patriarchal culture itself. She had managed to bring women into politics and scientific world, both traditionally male-dominated bastions. She had pronounced certain scientific marvels, which is relevant even today. Her idea of women’s’ participation in politics is simply ahead of her time but relevant in contemporary Indian politics. Here, an attempt has been made to review her pioneering work. Towards the end, there is also an effort to see the condition of Muslim women in contemporary India.

  5. Contemplation for Economists. Towards a Social Economy Based on Empathy and Compassion

    Directory of Open Access Journals (Sweden)

    Krzysztof T. Konecki

    2017-10-01

    Full Text Available The goal of the paper is to present the Buddhist approach to the economy and what we can learn from it. It demonstrates David Loy’s analysis of the meaning of money from the Buddhist perspective. Money becomes a reality symbol and an ego symbol. The paper also presents some conclusions from analysis of Buddhist prescriptions to the economic system according to Frederic Pryor. Stress is put on compassion and ethics, which show the ubiquitous interconnectedness that works for the well-being of the whole society/societies. The Buddhist approach to the economy is connected with pro-social values and compassion, and this paper looks at the contemporary economy and society from this point of view. Contemporary organizations are based on the greed, which is a feature not only of individuals but also of institutions (institutionalized greed. Work on the self-ego is an important practice (contemplation, mindfulness practice and meditation in limiting or eliminating greediness in the social and economic system in which we are immersed, but usually not aware of.

  6. The varieties of contemplative experience: A mixed-methods study of meditation-related challenges in Western Buddhists.

    Directory of Open Access Journals (Sweden)

    Jared R Lindahl

    Full Text Available Buddhist-derived meditation practices are currently being employed as a popular form of health promotion. While meditation programs draw inspiration from Buddhist textual sources for the benefits of meditation, these sources also acknowledge a wide range of other effects beyond health-related outcomes. The Varieties of Contemplative Experience study investigates meditation-related experiences that are typically underreported, particularly experiences that are described as challenging, difficult, distressing, functionally impairing, and/or requiring additional support. A mixed-methods approach featured qualitative interviews with Western Buddhist meditation practitioners and experts in Theravāda, Zen, and Tibetan traditions. Interview questions probed meditation experiences and influencing factors, including interpretations and management strategies. A follow-up survey provided quantitative assessments of causality, impairment and other demographic and practice-related variables. The content-driven thematic analysis of interviews yielded a taxonomy of 59 meditation-related experiences across 7 domains: cognitive, perceptual, affective, somatic, conative, sense of self, and social. Even in cases where the phenomenology was similar across participants, interpretations of and responses to the experiences differed considerably. The associated valence ranged from very positive to very negative, and the associated level of distress and functional impairment ranged from minimal and transient to severe and enduring. In order to determine what factors may influence the valence, impact, and response to any given experience, the study also identified 26 categories of influencing factors across 4 domains: practitioner-level factors, practice-level factors, relationships, and health behaviors. By identifying a broader range of experiences associated with meditation, along with the factors that contribute to the presence and management of experiences reported

  7. Induction therapy with the selective interleukin-23 inhibitor risankizumab in patients with moderate-to-severe Crohn's disease: a randomised, double-blind, placebo-controlled phase 2 study

    NARCIS (Netherlands)

    Feagan, Brian G.; Sandborn, William J.; D'Haens, Geert; Panés, Julián; Kaser, Arthur; Ferrante, Marc; Louis, Edouard; Franchimont, Denis; Dewit, Olivier; Seidler, Ursula; Kim, Kyung-Jo; Neurath, Markus F.; Schreiber, Stefan; Scholl, Paul; Pamulapati, Chandrasena; Lalovic, Bojan; Visvanathan, Sudha; Padula, Steven J.; Herichova, Ivona; Soaita, Adina; Hall, David B.; Böcher, Wulf O.

    2017-01-01

    Background The interleukin-23 pathway is implicated genetically and biologically in the pathogenesis of Crohn's disease. We aimed to assess the efficacy and safety of risankizumab (BI 655066, Boehringer Ingelheim, Ingelheim, Germany), a humanised monoclonal antibody targeting the p19 subunit of

  8. 75 FR 75498 - Manufacturer of Controlled Substances; Notice of Registration

    Science.gov (United States)

    2010-12-03

    ..., (75 FR 32506), Boehringer Ingelheim Chemicals, Inc., 2820 N. Normandy Drive, Petersburg, Virginia... has considered the factors in 21 U.S.C. 823(a) and determined that the registration of Boehringer... with the public interest at this time. DEA has investigated Boehringer Ingelheim Chemicals, Inc. to...

  9. Contemplating what I would do if someone got in my house: intentions of older homebound women living alone.

    Science.gov (United States)

    Porter, Eileen J

    2008-01-01

    There is little research guiding interventions to help old homebound women prepare to manage an intrusion event. During a phenomenological study of the experience of reaching help quickly, I compared intentions during a possible intrusion event for 9 women subscribing to a personal emergency response system and 5 nonsubscribers. The phenomenon of contemplating what I would do if an intruder got in my home had 4 components. Only 2 personal emergency response system subscribers voiced the definitive intention to use the personal emergency response system. Findings underpin a new empirical perspective of competence grounded in situations relevant to living alone at home rather than specific tasks of daily living.

  10. Journeying from the philosophical contemplation of constructivism to the methodological pragmatics of health services research.

    Science.gov (United States)

    Appleton, Jane V; King, Lindy

    2002-12-01

    This paper presents our journey through a contemplation of the philosophical origins of constructivism to consider its role as an active methodology in qualitative research. The first part of the paper summarizes the philosophical background of constructivism and the five principles underpinning this paradigm as described through the works of Guba and Lincoln. The philosophical roots of constructivism are then compared with postpositivism, critical realism and participatory inquiry. The paper moves on to consider their common methodological steps, before examining how the constructivist research strategy is being adopted and adapted within the pragmatics of health service research. Recent studies will be drawn upon to illustrate the use of constructivist methodology. Questions are raised about the role of philosophy and the extent to which it should or does underpin or influence qualitative research strategies. We believe that if researchers gain an understanding of both philosophy and methodology a richer and more robust study is likely to result.

  11. A Systematic Review of Transcendent States Across Meditation and Contemplative Traditions.

    Science.gov (United States)

    Wahbeh, Helané; Sagher, Amira; Back, Wallis; Pundhir, Pooja; Travis, Frederick

    Across cultures and throughout history, transcendent states achieved through meditative practices have been reported. The practices to attain transcendent states vary from transcendental meditation to yoga to contemplative prayer, to other various forms of sitting meditation. While these transcendent states are ascribed many different terms, those who experience them describe a similar unitive, ineffable state of consciousness. Despite the common description, few studies have systematically examined transcendent states during meditation. The objectives of this systematic review were to: 1) characterize studies evaluating transcendent states associated with meditation in any tradition; 2) qualitatively describe physiological and phenomenological outcomes collected during transcendent states and; 3) evaluate the quality of these studies using the Quality Assessment Tool. Medline, PsycINFO, CINAHL, AltHealthWatch, AMED, and the Institute of Noetic Science Meditation Library were searched for relevant papers in any language. Included studies required adult participants and the collection of outcomes before, during, or after a reported transcendent state associated with meditation. Twenty-five studies with a total of 672 combined participants were included in the final review. Participants were mostly male (61%; average age 39 ± 11 years) with 12.7 ± 6.6 (median 12.6; range 2-40) average years of meditation practice. A variety of meditation traditions were represented: (Buddhist; Christian; Mixed (practitioners from multiple traditions); Vedic: Transcendental Meditation and Yoga). The mean quality score was 67 ± 13 (100 highest score possible). Subjective phenomenology and the objective outcomes of electroencephalography (EEG), electrocardiography, electromyography, electrooculogram, event-related potentials, functional magnetic resonance imaging, magnetoencephalography, respiration, and skin conductance and response were measured. Transcendent states were most

  12. What Researchers Should Know and be Able to do When Contemplating Involvement in Education and Outreach

    Science.gov (United States)

    Ridky, R. W.

    2004-12-01

    At some point in their careers, many researchers are motivated to share what they have learned with a wider audience. As their studies mature, and national awareness for more effective integration of research and education intensifies, researchers are increasingly directing efforts toward informal and pre-college educational sectors. Each initiative comes with good intentions, but many fall short of intended benefit. Quality education and outreach programs develop from the same precepts that shape research programs of high professional standing. A researcher is most likely to make useful contributions when they are willing and able to implement familiar research principles to broader educational endeavors. As with research endeavors, principles of significance, literacy, design, feasibility, analysis and dissemination need to be regarded as essential indicators of education program quality. It is helpful to provide researchers who are contemplating more active educational involvement with more than casual understanding of the purposes underlying their pending contributions. Such understanding is premised on the tenet that education and research are always in the public service and therefore inextricably bound at all levels. Both research and education have, as their ultimate goal, enhanced scientific literacy of the citizenry. By example, it can be shown that the best-supported programs, within government and academia, recognize that the way they translate knowledge and make it available to scientific organizations and the public is critical to their intrinsic societal value and level of support. As education conjures up a host of operational meanings arising from one's own values and experiences, the knowledge researchers bring to pre-college and informal educational settings is often based on personal experience rather than on education research, practice and policy. Researchers may believe that because they spent 13 years in school, an additional 4 years at a

  13. Once-daily long-acting beta-agonists for chronic obstructive pulmonary disease: an indirect comparison of olodaterol and indacaterol

    Directory of Open Access Journals (Sweden)

    Roskell NS

    2014-07-01

    Full Text Available Neil S Roskell,1 Antonio Anzueto,2 Alan Hamilton,3 Bernd Disse,4 Karin Becker5 1Statistics, Bresmed Health Solutions Ltd, Sheffield, UK; 2School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA; 3Medical Department, Boehringer Ingelheim (Canada Ltd, Burlington, ON, Canada; 4Medical Department, Boehringer Ingelheim GmbH, Ingelheim am Rhein, Germany; 5Global Health Economics and Outcomes Research, Boehringer Ingelheim GmbH, Ingelheim am Rhein, Germany Purpose: In the absence of head-to-head clinical trials comparing the once-daily, long-acting beta2-agonists olodaterol and indacaterol for the treatment of chronic obstructive pulmonary disease (COPD, an indirect treatment comparison by systematic review and synthesis of the available clinical evidence was conducted. Methods: A systematic literature review of randomized, controlled clinical trials in patients with COPD was performed to evaluate the efficacy and safety of olodaterol and indacaterol. Network meta-analysis and adjusted indirect comparison methods were employed to evaluate treatment efficacy, using outcomes based on trough forced expiratory volume in 1 second (FEV1, Transition Dyspnea Index, St George’s Respiratory Questionnaire total score and response, rescue medication use, and proportion of patients with exacerbations. Results: Eighteen trials were identified for meta-analysis (eight, olodaterol; ten, indacaterol. Olodaterol trials included patients of all severities, whilst indacaterol trials excluded patients with very severe COPD. Concomitant maintenance bronchodilator use was allowed in most olodaterol trials, but not in indacaterol trials. When similarly designed trials/data were analyzed for change from baseline in trough FEV1 (liters, the following mean differences (95% confidence interval were observed: trials excluding concomitant bronchodilator: indacaterol 75 mcg versus olodaterol 5 mcg, –0.005 (–0.077 to 0.067, and indacaterol 150 mcg

  14. Pharmacokinetics and safety of olodaterol administered with the Respimat Soft Mist inhaler in subjects with impaired hepatic or renal function

    Directory of Open Access Journals (Sweden)

    Kunz C

    2016-03-01

    Full Text Available Christina Kunz,1 Doreen Luedtke,1 Anna Unseld,2 Alan Hamilton,3 Atef Halabi,4 Martina Wein,5 Stephan Formella6 1Translational Medicine and Clinical Pharmacology, 2Global Biometrics and Clinical Applications, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach, Germany; 3Boehringer Ingelheim, Burlington, ON, Canada; 4CRS Clinical Research Services Kiel GmbH, Kiel, 5Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach, 6Medicine Coordination, Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim, Germany Purpose: In two trials, the influences of hepatic and renal impairment on the pharmacokinetics of olodaterol, a novel long-acting inhaled β2-agonist for treatment of COPD, were investigated.Subjects and methods: The first trial included eight subjects with mild hepatic function impairment (Child–Pugh A, eight subjects with moderate impairment (Child–Pugh B, and 16 matched healthy subjects with normal hepatic function. The second trial included eight subjects with severe renal impairment (creatinine clearance <30 mL·min-1 and 14 matched healthy subjects with normal renal function. Subjects received single doses of 20 or 30 µg olodaterol administered with the Respimat Soft Mist inhaler.Results: Olodaterol was well tolerated in all subjects. The geometric mean ratios and 90% confidence intervals of dose-normalized area under the plasma concentration-time curve from time zero to 4 hours (AUC0–4 for subjects with mild and moderate hepatic impairment compared to healthy subjects were 97% (75%–125% and 105% (79%–140%, respectively. Corresponding values for dose-normalized maximum concentration (Cmax were 112% (84%–151% (mild impairment and 99% (73%–135% (moderate impairment. The geometric mean ratio (90% confidence interval of AUC0–4 for subjects with severe renal impairment compared to healthy subjects was 135% (94%–195%, and for Cmax was 137% (84%–222%. There was no significant relationship

  15. Idiopathic pulmonary fibrosis: current treatment options and critical appraisal of nintedanib

    Directory of Open Access Journals (Sweden)

    Bonella F

    2015-12-01

    Full Text Available Francesco Bonella,1 Susanne Stowasser,2 Lutz Wollin3 1Interstitial and Rare Lung Disease Unit, Ruhrlandklinik, University Hospital, University of Duisburg-Essen, Essen, 2Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, 3Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany Abstract: Idiopathic pulmonary fibrosis (IPF is the most common type of idiopathic interstitial pneumonia and is characterized by a poor prognosis, with an estimated 5-year survival of approximately 20%. Progressive and irreversible lung functional impairment leads to chronic respiratory insufficiency with a severely impaired quality of life. In the last 2 decades, novel treatments for IPF have been developed as a consequence of an increasing understanding of disease pathogenesis and pathobiology. In IPF, injured dysfunctional alveolar epithelial cells promote fibroblast recruitment and proliferation, resulting in scarring of the lung tissue. Recently, pirfenidone and nintedanib have been approved for the treatment of IPF, having shown efficacy to slow functional decline and disease progression. This article focuses on the pharmacologic characteristics and clinical evidence supporting the use of nintedanib, a potent small-molecule tyrosine kinase inhibitor, as therapy for IPF. After introducing the mechanism of action and pharmacokinetics, an overview of the safety and efficacy results from the most recent clinical trials of nintedanib in IPF is presented. Keywords: tyrosine kinase, disease progression, treatment outcome, usual interstitial pneumonia, therapeutics

  16. Pingevabalt / Priidu Beier

    Index Scriptorium Estoniae

    Beier, Priidu, 1957-

    1995-01-01

    Arvustus: Vee, Elo. Ingelheim. Tln.: Eesti Raamat, 1995. Vastukaja : Viiding, Elo. Kirjaniku nimest ja veest // Kultuurileht. - 1995. - 10.nov. - Lk.17; Kivisildnik, Sven. Intuitiivne geneetika ja ustavuse piirid // Postimees. - 1996. - 4.märts. - Lk.18

  17. Evaluation of possible interaction among drugs contemplated for use during manned space flights. Part 1: Summary from progress report dated 31 October 1973. Part 2: Progress report for the period November 1973 to June 1974

    Science.gov (United States)

    1974-01-01

    Possible interactions among drugs contemplated for use during manned spaceflights have been studied in several animal species. The following seven drugs were investigated: nitrofurantoin, chloral hydrate, hexobarbital, phenobarbital, flurazepam, diphenoxylate, and phenazopyridine. Particular combinations included: chloral hydrate, hexobarbital or flurazepam with nitrofurantoin; phenobarbital or flurazepam with phenazopyridine; and diphenoxylate with two dose formulations of nitrofurantoin. The mechanism of action and an explanation of the interaction between diphenoxylate and nitrofurantoin still remains unclear. In man, the interaction does not appear to be significant, affecting only two subjects out of six and with only one dose formulation (Furadantin).

  18. Forecasting the future reimbursement system of Korean National Health Insurance: a contemplation focusing on global budget and Neo-KDRG-based payment systems.

    Science.gov (United States)

    Kim, Yang-Kyun

    2012-05-01

    With the adoption of national health insurance in 1977, Korea has been utilizing fee-for-service payment with contract-based healthcare reimbursement system in 2000. Under the system, fee-for-service reimbursement has been accused of augmenting national healthcare expenditure by excessively increasing service volume. The researcher examined in this paper two major alternatives including diagnosis related group-based payment and global budget to contemplate the future of reimbursement system of Korean national health insurance. Various literature and preceding studies on pilot project and actual implementation of Neo-KDRG were reviewed. As a result, DRG-based payment was effective for healthcare cost control but low in administrative efficiency. Global budget may be adequate for cost control and improving the quality of healthcare and administrative efficiency. However, many healthcare providers disagree that excess care arising from fee-for-service payment alone has led to financial deterioration of national health insurance and healthcare institutions should take responsibility with global budget payment as an appropriate solution. Dissimilar payment systems may be applied to different types of institutions to reflect their unique attributes, and this process can be achieved step-by-step. Developing public sphere among the stakeholders and striving for consensus shall be kept as collateral to attain the desirable reimbursement system in the future.

  19. Verslag symposium : "M€€r welzijn zonder pijn"

    NARCIS (Netherlands)

    Driesse, M.; Kluivers-Poodt, M.

    2010-01-01

    Op 27 april 2010 hield men in Lelystad het symposium 'Meer welzijn zonder pijn' over het thema welzijn bij landbouwhuisdieren, georganiseerd door Wageningen UR Livestock Research in samenwerking met Boehringer Ingelheim. Hoewel het symposium primair bedoeld was voor rundvee- en varkensdierenartsen,

  20. Development of Respimat® Soft Mist™ Inhaler and its clinical utility in respiratory disorders

    Directory of Open Access Journals (Sweden)

    Dalby RN

    2011-09-01

    Full Text Available Richard N Dalby1, Joachim Eicher2, Bernd Zierenberg21Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD, USA; 2Boehringer Ingelheim, Ingelheim, GermanyAbstract: The Respimat® Soft Mist™ Inhaler (SMI (Boehringer Ingelheim International GmbH, Ingelheim, Germany was developed in response to the need for a pocket-sized device that can generate a single-breath, inhalable aerosol from a drug solution using a patient-independent, reproducible, and environmentally friendly energy supply. This paper describes the design and evolution of this innovative device from a laboratory concept model and the challenges that were overcome during its development and scaleup to mass production. A key technical breakthrough was the uniblock, a component combining filters and nozzles and made of silicon and glass, through which drug solution is forced using mechanical power. This allows two converging jets of solution to collide at a controlled angle, generating a fine aerosol of inhalable droplets. The mechanical energy comes from a spring which is tensioned by twisting the base of the device before use. Additional features of the Respimat® SMI include a dose indicator and a lockout mechanism to avoid the problems of tailing-off of dose size seen with pressurized metered dose inhalers. The Respimat® SMI aerosol cloud has a unique range of technical properties. The high fine particle fraction allied with the low velocity and long generation time of the aerosol translate into a higher fraction of the emitted dose being deposited in the lungs compared with aerosols from pressurized metered dose inhalers and dry powder inhalers. These advantages are realized in clinical trials in adults and children with obstructive lung diseases, which have shown that the efficacy and safety of a pressurized metered dose inhaler formulation of a combination bronchodilator can be matched by a Respimat® SMI formulation containing only one half or one quarter

  1. Stroke and recurrent haemorrhage associated with antithrombotic treatment after gastrointestinal bleeding in patients with atrial fibrillation

    DEFF Research Database (Denmark)

    Staerk, Laila; Lip, Gregory Y H; Olesen, Jonas B

    2015-01-01

    with better outcomes for all cause mortality and thromboembolism compared with patients who did not resume treatment. This was despite an increased longitudinal associated risk of bleeding. FUNDING, COMPETING INTERESTS, DATA SHARING: This study was supported by a grant from Boehringer-Ingelheim. Competing...

  2. Availability, affordability, and consumption of fruits and vegetables in 18 countries across income levels: findings from the Prospective Urban Rural Epidemiology (PURE study

    Directory of Open Access Journals (Sweden)

    Victoria Miller, BSc

    2016-10-01

    Funding: Population Health Research Institute, the Canadian Institutes of Health Research, Heart and Stroke Foundation of Ontario, AstraZeneca (Canada, Sanofi-Aventis (France and Canada, Boehringer Ingelheim (Germany and Canada, Servier, GlaxoSmithKline, Novartis, King Pharma, and national or local organisations in participating countries.

  3. 76 FR 36577 - Manufacturer of Controlled Substances; Notice of Application

    Science.gov (United States)

    2011-06-22

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on May 4, 2011, Boehringer Ingelheim Chemicals Inc., 2820 N. Normandy Drive...

  4. 75 FR 32506 - Manufacturer of Controlled Substances; Notice of Application

    Science.gov (United States)

    2010-06-08

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application Pursuant to Sec. 1301.33(a) of Title 21 of the Code of Federal Regulations (CFR), this is notice that on April 12, 2010, Boehringer Ingelheim Chemicals Inc., 2820 N. Normandy Drive...

  5. Diffusion-weighted magnetic resonance imaging in ileocolonic Crohn's disease

    DEFF Research Database (Denmark)

    Juel, Mie A; Rafaelsen, Søren Rafael; Nathan, Torben

    protocol contained coronal e-thrive and SShT2 with free-breathing and a factor b fixed at 800 s/mm2. Patients were examined in the prone position before and after intravenous administration of 20 mg Hyoscin Butylbromide (Buscopan®, Boehringer Ingelheim, Basel, Switzerland). Ileocolonoscopy with Simple...

  6. Ipratropium bromide delivered by metered-dose aerosol to infant ...

    African Journals Online (AJOL)

    Two methods of administration of ipratropium bromide (Atrovent; Boehringer Ingelheim) to wheezing children'< 25 months of age were compared: (i) the conventional nebulisation (15 children); and (ii) a metered-dose aerosol plus spacer and mask (MDA group, 17 children). The drug induced a significant and similar fall in ...

  7. The check-up: in-person, computerized, and telephone adaptations of motivational enhancement treatment to elicit voluntary participation by the contemplator

    Directory of Open Access Journals (Sweden)

    Picciano Joseph F

    2007-01-01

    Full Text Available Abstract Countless barriers come between people who are struggling with substance abuse and those charged with providing substance abuse treatment. The check-up, a form of motivational enhancement therapy, is a harm reduction intervention that offers a manner of supporting individuals by lowering specific barriers to reaching those who are untreated. The check-up was originally developed to reach problem drinkers who were neither seeking treatment nor self-initiating change. The intervention, marketed as an opportunity to take stock of one's experiences, involves an assessment and personalized feedback delivered with a counseling style termed motivational interviewing. Check-ups can be offered in care settings to individuals who, as a result of screening, manifest risk factors for specific disorders such as alcoholism. They can also be free-standing and publicized widely to the general public. This paper will discuss illustrations of in-person, computerized, in-school, and telephone applications of the free-standing type of check-up with reference to alcohol consumers, adult and adolescent marijuana smokers, and gay/bisexual males at risk for sexual transmission of HIV. The paper's major focus is to highlight how unique features of each application have the potential of reducing barriers to reaching specific at-risk populations. Also considered are key policy issues such as how check-up services can be funded, which venues are appropriate for the delivery of check-up interventions, pertinent competency criteria in evaluating staff who deliver this intervention, how marketing can be designed to reach contemplators in untreated at-risk populations, and how a check-up's success ought to be defined.

  8. Ettevõttel lasub ühiskondlik vastutus / Karen Schmidt

    Index Scriptorium Estoniae

    Schmidt, Karen

    2011-01-01

    Terve Eesti SA algatusel Eesti ettevõtete poolt moodustatud koalitsioonist "Ettevõtted HIV vastu", kuhu kuuluvad Hill & Knowlton, Nordecon, Swedbank, TNS Emor, Coca-Cola, Johnson & Johnson, Rimi Eesti Food, DHL Estonia, Boehringer Ingelheim, Radisson BLU Hotell Tallinn ja TBWA/Guvatrak. Koalitsiooni töös osales kolm aastat ka Statoil

  9. Ipratropium bromide delivered by metered-dose aerosol to infant ...

    African Journals Online (AJOL)

    1990-08-21

    Aug 21, 1990 ... Two methods of administration of ipratropium bromide. (Atrovent; Boehringer Ingelheim) to wheezing children'< 25 months of age were compared: (I) the conventional nebulisa- tion (15 children); and (iI) a metered-dose aerosol plus spacer and mask (MDA group, 17 children). The drug induced a significant ...

  10. "Partners in Science": A Model Cooperative Program Introducing High School Teachers and Students to Leading-Edge Pharmaceutical Science

    Science.gov (United States)

    Woska, Joseph R., Jr.; Collins, Danielle M.; Canney, Brian J.; Arcario, Erin L.; Reilly, Patricia L.

    2005-01-01

    "Partners in Science" is a cooperative program between Boehringer Ingelheim Pharmaceuticals, Inc. and area high schools in the community surrounding our Connecticut campus. It is a two-phase program that introduces high school students and teachers to the world of drug discovery and leading-edge pharmaceutical research. Phase 1 involves…

  11. Similar Efficacy and Safety of Basaglar® and Lantus® in Patients with Type 2 Diabetes in Age Groups (< 65 Years, ≥ 65 Years): A Post Hoc Analysis from the ELEMENT-2 Study.

    Science.gov (United States)

    Pollom, Robyn K; Costigan, Timothy; Lacaya, Lyndon B; Ilag, Liza L; Hollander, Priscilla A

    2018-04-01

    To compare efficacy and safety of Basaglar ® [insulin glargine 100 units/mL; LY insulin glargine (LY IGlar)] to Lantus ® [insulin glargine 100 units/mL; SA insulin glargine (SA IGlar)] in older (≥ 65 years) or younger (Eli Lilly and Company and Boehringer-Ingelheim.

  12. Higher lung deposition with Respimat® Soft Mist™ Inhaler than HFA-MDI in COPD patients with poor technique

    Directory of Open Access Journals (Sweden)

    Peter Brand

    2008-08-01

    Full Text Available Peter Brand1, Bettina Hederer2, George Austen3, Helen Dewberry3, Thomas Meyer41RWTH, Aachen, Germany; 2Boehringer Ingelheim, Ingelheim, Germany; 3Boehringer Ingelheim, Bracknell, UK; 4Inamed Research, Gauting, GermanyAbstract: Aerosols delivered by Respimat® Soft Mist™ Inhaler (SMI are slower-moving and longer-lasting than those from pressurized metered-dose inhalers (pMDIs, improving the efficiency of pulmonary drug delivery to patients. In this four-way cross-over study, adults with chronic obstructive pulmonary disease (COPD and with poor pMDI technique received radiolabelled Berodual® (fenoterol hydrobromide 50 µg/ipratropium bromide 20 µg via Respimat® SMI or hydrofluoroalkane (HFA-MDI (randomized order on test days 1 and 2, with no inhaler technique training. The procedure was repeated on test days 3 and 4 after training. Deposition was measured by gamma scintigraphy. All 13 patients entered (9 males, mean age 62 years; FEV1 46% of predicted inhaled too fast at screening (peak inspiratory flow rate [IF]: 69–161 L/min. Whole lung deposition was higher with Respimat® SMI than with pMDI for untrained (37% of delivered dose vs 21% of metered dose and trained patients (53% of delivered vs 21% of metered dose (pSign-Test = 0.15; pANOVA< 0.05. Training also improved inhalation profiles (slower average and peak IF as well as longer breath-hold time. Drug delivery to the lungs with Respimat® SMI is more efficient than with pMDI, even with poor inhaler technique. Teaching patients to hold their breath as well as to inhale slowly and deeply increased further lung deposition using Respimat® SMI.Keywords: chronic obstructive pulmonary disease, drug delivery, inhalation, metered-dose inhaler, poor inhalation technique, training

  13. Recreational 3,4-methylenedioxy-N-methylamphetamine (MDMA) or 'ecstasy' and self-focused compassion: Preliminary steps in the development of a therapeutic psychopharmacology of contemplative practices.

    Science.gov (United States)

    Kamboj, Sunjeev K; Kilford, Emma J; Minchin, Stephanie; Moss, Abigail; Lawn, Will; Das, Ravi K; Falconer, Caroline J; Gilbert, Paul; Curran, H Valerie; Freeman, Tom P

    2015-09-01

    3,4-methylenedioxy-N-methylamphetamine (MDMA) produces diverse pro-social effects. Cognitive training methods rooted in Eastern contemplative practices also produce these effects through the development of a compassionate mindset. Given this similarity, we propose that one potential mechanism of action of MDMA in psychotherapy is through enhancing effects on intrapersonal attitudes (i.e. pro-social attitudes towards the self). We provide a preliminary test of this idea. Recreational MDMA (ecstasy) users were tested on two occasions, having consumed or not consumed ecstasy. Self-critical and self-compassionate responses to self-threatening scenarios were assessed before (T1) and after (T2) ecstasy use (or non-use), and then after compassionate imagery (T3). Moderating roles of dispositional self-criticism and avoidant attachment were examined. Separately, compassionate imagery and ecstasy produced similar sociotropic effects, as well as increases in self-compassion and reductions in self-criticism. Higher attachment-related avoidance was associated with additive effects of compassionate imagery and ecstasy on self-compassion. Findings were in line with MDMA's neuropharmacological profile, its phenomenological effects and its proposed adjunctive use in psychotherapy. However, although conditions were balanced, the experiment was non-blind and MDMA dose/purity was not determined. Controlled studies with pharmaceutically pure MDMA are still needed to test these effects rigorously. © The Author(s) 2015.

  14. Contemplation at Last Sight

    DEFF Research Database (Denmark)

    Reeh, Henrik

    2015-01-01

    Pr. 1. juli 2015 gik de såkaldte klippekort ud af brug efter i mere end fyrre år at have formidlet mellem individ, offentlig transport og byrum i København og hele hovedstadsregionen. Undersøgelsen rettes især mod de automater, som har stået for afstemplingen af klippekortene. Disse automater - a...

  15. Contemplating future energy options

    International Nuclear Information System (INIS)

    Pooley, D.

    2005-01-01

    All political parties in the UK accept that we should move away from our reliance on fossil fuels towards a much greater use of alternative energy technologies. Nuclear power is one of these but finds minimal support in the political spectrum. The article reviews the European Commission's Advisory Group on Energy submission to the EC's report entitled 'Key Tasks for European Energy R and D'. The 'strength and weaknesses' of the various 'alternative energy' systems (including nuclear power) are summarised and then the key R and D tasks which, if they are carried out successfully, should make the eight selected technologies significantly more attractive. However, the message here is clear enough: there are no easy options, only a range of very imperfect possibilities, despite what enthusiastic proponents of each may say. Nuclear fission is certainly one of the most attractive options available, but the industry needs to continue to strive to eliminate the possibility of significant off-site releases, whether caused by plant failure or by human error or intention, and to prove beyond reasonable doubt the safety of high-level radioactive waste disposal. (author)

  16. The efficacy and safety of combined tiotropium and olodaterol via the Respimat® inhaler in patients with COPD: results from the Japanese sub-population of the Tonado® studies

    Directory of Open Access Journals (Sweden)

    Ichinose M

    2016-08-01

    Full Text Available Masakazu Ichinose,1 Hiroyuki Taniguchi,2 Ayako Takizawa,3 Lars Grönke,4 Lazaro Loaiza,4 Florian Voß,4 Yihua Zhao,5 Yoshinosuke Fukuchi61Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; 2Department of Respiratory Medicine and Allergy, Tosei General Hospital, Aichi, Japan; 3Nippon Boehringer Ingelheim Co. Ltd, Tokyo, Japan; 4Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany; 5Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA; 6Juntendo University School of Medicine, Tokyo, JapanBackground: The efficacy and safety of once-daily tiotropium + olodaterol (T+O maintenance treatment was demonstrated in the large, multinational, replicate, randomized, Phase III, Tonad® 1 (NCT01431274 and 2 (NCT01431287 studies in patients with moderate to very severe COPD. However, there may be racial differences in the effects of T+O on lung function in patients with COPD.Methods: In this Tondao® subgroup analysis, we assessed efficacy and safety of T+O in Japanese participants.Results: Versus the overall population, the 413 Japanese patients randomized and treated were slightly older, with more men, lower body mass index, lower baseline St George’s Respiratory Questionnaire (SGRQ scores, fewer current smokers, but with higher pack-year smoking history. A lower proportion of Japanese patients used inhaled corticosteroids, short-acting muscarinic antagonists, or short- or long-acting β-adrenergic agonists at baseline, but use of long-acting muscarinic antagonists was higher. At Week 24, mean improvements with T+O 5/5 µg in forced expiratory volume in 1 second area under the curve from 0–3 hours response were 151 mL versus olodaterol and 134 mL versus tiotropium 5 µg; mean improvements with T+O 2.5/5 µg were 87 mL versus olodaterol and 70 mL versus tiotropium 2.5 µg. Mean improvements with T+O 5/5 µg in trough forced expiratory volume in 1 second were 131 mL versus

  17. A Systematic Review of the Role of Dysfunctional Wound Healing in the Pathogenesis and Treatment of Idiopathic Pulmonary Fibrosis

    Directory of Open Access Journals (Sweden)

    Alan Betensley

    2016-12-01

    Full Text Available Idiopathic pulmonary fibrosis (IPF is a chronic, progressive interstitial lung disorder showcasing an interaction between genetic predisposition and environmental risks. This usually involves the coaction of a mixture of cell types associated with abnormal wound healing, leading to structural distortion and loss of gas exchange function. IPF bears fatal prognosis due to respiratory failure, revealing a median survival of approximately 2 to 3 years. This review showcases the ongoing progress in understanding the complex pathophysiology of IPF and it highlights the latest potential clinical treatments. In IPF, various components of the immune system, particularly clotting cascade and shortened telomeres, are highly involved in disease pathobiology and progression. This review also illustrates two US Food and Drug Administration (FDA-approved drugs, nintedanib (OFEV, Boehringer Ingelheim, Ingelheim am Rhein, Germany and pirfenidone (Esbriet, Roche, Basel, Switzerland, that slow IPF progression, but unfortunately neither drug can reverse the course of the disease. Although the mechanisms underlying IPF remain poorly understood, this review unveils the past and current advances that encourage the detection of new IPF pathogenic pathways and the development of effective treatment methods for the near future.

  18. Lipids as organizers of cell membranes.

    Science.gov (United States)

    Kornmann, Benoît; Roux, Aurélien

    2012-08-01

    The 105th Boehringer Ingelheim Fonds International Titisee Conference 'Lipids as Organizers of Cell Membranes' took place in March 2012, in Germany. Kai Simons and Gisou Van der Goot gathered cell biologists and biophysicists to discuss the interplay between lipids and proteins in biological membranes, with an emphasis on how technological advances could help fill the gap in our understanding of the lipid part of the membrane.

  19. Determination of the Role of Estrogen Receptors and Estrogen Regulated Genes in B cell Autoreactivity. Addendum

    Science.gov (United States)

    2012-07-01

    Weidler C, Harle P, Schedel J, Schmidt M, Scholmerich J, Straub RH. (2004) Patients with rheumatoid arthritis and systemic lupus erythe- matosus have...Bronx, New York, United States of America; and 3current affiliation: Boehringer Ingelheim Pharmaceuticals , Ridgefield, Connecticut, United States of...Institutional Animal Care and Use Committee. WT BALB/c mice, ERα- deficient (β-sufficient) and ERβ-deficient (α-sufficient) C57Bl/6 mice were obtained from

  20. Promoting Mindfulness through Contemplative Education

    Science.gov (United States)

    Mahani, Sepideh

    2012-01-01

    For years, higher education institutions in the United States have developed courses in the field of liberal education that focus on social, political, economic and environmental issues with a global outlook. As such, students are taught critical thinking, critical reasoning, and critical writing skills. While students learn to engage in debates,…

  1. CONTEMPLATION AND SOCIAL TRANSFORMATION: THE ...

    African Journals Online (AJOL)

    1 This essay is adapted from The Shults Lectures given at St Bernard's School of. Theology ... (1948) to the sympathetic and committed observations on the public world in. Conjectures of a ..... provided by normal socioeconomic ties. From its ...

  2. Contemplating Whitehead's Freedom and Discipline

    Science.gov (United States)

    Jones, Colin

    2007-01-01

    This paper extends the previous application of Alfred Whitehead's educational ideas to the domain of enterprise education. In doing so, a unique approach to enterprise education is illustrated that links students to their reality whilst also connecting the curriculum to contemporary entrepreneurship theory. The paper reports upon past cycles of…

  3. Conception through build of an automated liquids processing system for compound management in a low-humidity environment.

    Science.gov (United States)

    Belval, Richard; Alamir, Ab; Corte, Christopher; DiValentino, Justin; Fernandes, James; Frerking, Stuart; Jenkins, Derek; Rogers, George; Sanville-Ross, Mary; Sledziona, Cindy; Taylor, Paul

    2012-12-01

    Boehringer Ingelheim's Automated Liquids Processing System (ALPS) in Ridgefield, Connecticut, was built to accommodate all compound solution-based operations following dissolution in neat DMSO. Process analysis resulted in the design of two nearly identical conveyor-based subsystems, each capable of executing 1400 × 384-well plate or punch tube replicates per batch. Two parallel-positioned subsystems are capable of independent execution or alternatively executed as a unified system for more complex or higher throughput processes. Primary ALPS functions include creation of high-throughput screening plates, concentration-response plates, and reformatted master stock plates (e.g., 384-well plates from 96-well plates). Integrated operations included centrifugation, unsealing/piercing, broadcast diluent addition, barcode print/application, compound transfer/mix via disposable pipette tips, and plate sealing. ALPS key features included instrument pooling for increased capacity or fail-over situations, programming constructs to associate one source plate to an array of replicate plates, and stacked collation of completed plates. Due to the hygroscopic nature of DMSO, ALPS was designed to operate within a 10% relativity humidity environment. The activities described are the collaborative efforts that contributed to the specification, build, delivery, and acceptance testing between Boehringer Ingelheim Pharmaceuticals, Inc. and the automation integration vendor, Thermo Scientific Laboratory Automation (Burlington, ON, Canada).

  4. Boehringer Ingleheim's selective glucocorticoid receptor agonist development candidate: evaluation of WO2010141331, WO2010141332 and WO2010141333.

    Science.gov (United States)

    Norman, Peter

    2011-07-01

    Three applications from Boehringer Ingelheim all relate to the preparation of non-steroidal glucocorticoid receptor agonists useful in the treatment of inflammatory respiratory diseases. The first two applications claim chiral processes for the preparation of these compounds or intermediates useful therein. These provide two alternative routes, respectively, using achiral and chiral reagents. The third application relates to the preparation of a crystalline salt of the preferred compound on a multi-kilogram scale in micronised form.

  5. Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1)

    DEFF Research Database (Denmark)

    Machiels, Jean-Pascal H; Haddad, Robert I; Fayette, Jérôme

    2015-01-01

    BACKGROUND: Patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (HNSCC) progressing after first-line platinum regimens have a poor prognosis and few treatment options. Afatinib, an irreversible ERBB family blocker, has shown efficacy in a phase 2 study in this setting......%]), and neutropenia (1 [... provide important new insights into the treatment of this patient population and support further investigations with irreversible ERBB family blockers in HNSCC. FUNDING: Boehringer Ingelheim....

  6. Assessing patient report of function: content validity of the Functional Performance Inventory-Short Form (FPI-SF in patients with chronic obstructive pulmonary disease (COPD

    Directory of Open Access Journals (Sweden)

    Leidy NK

    2012-08-01

    Full Text Available Nancy Kline Leidy,1 Alan Hamilton,2 Karin Becker31Outcomes Research, United BioSource Corporation, Bethesda, MD, USA; 2Medical Department, Boehringer Ingelheim (Canada Ltd, Burlington, ON, Canada; 3Global Health Economics and Outcomes Research, Boehringer Ingelheim GmbH, Ingelheim am Rhein, GermanyPurpose: The performance of daily activities is a major challenge for people with chronic obstructive pulmonary disease (COPD. The Functional Performance Inventory (FPI was developed based on an analytical framework of functional status and qualitative interviews with COPD patients describing these difficulties. The 65-item FPI was reduced to a 32-item short form (SF through a systematic process of qualitative and quantitative item reduction and formatted for greater clarity and ease of use. This study examined the content validity of the reduced, reformatted form of the instrument, the FPI-SF.Patients and methods: Qualitative cognitive interviews were conducted with COPD patients recruited from three geographically diverse pulmonary clinics in the United States. Interviews were designed to assess respondent interpretation of the instrument, evaluate clarity and ease of completion, and identify any new activities participants found important and difficult to perform that were not represented by the existing items.Results: Twenty subjects comprised the sample; 12 (60% were male, 14 (70% were Caucasian, the mean age was 63.0 ± 11.3 years, 12 (60% were retired, the mean forced expiratory volume in 1 second (FEV1 was 1.5 ± 0.5 L, and the mean percent predicted FEV1 was 48.4% ± 13.1%. Participants understood the FPI-SF as intended, including instructions, items, and response options. Two minor formatting changes were suggested to improve clarity of presentation. Participants found the content of the FPI-SF to be comprehensive, with items covering activities they felt were important and often difficult to perform.Conclusion: These results, together with

  7. Nicoboxil/nonivamide cream effectively and safely reduces acute nonspecific low back pain – a randomized, placebo-controlled trial

    Directory of Open Access Journals (Sweden)

    Blahova Z

    2016-12-01

    Full Text Available Zuzana Blahova,1 Janina Claudia Holm,1 Thomas Weiser,2 Erika Richter,2 Matthias Trampisch,2 Elena Akarachkova3 1Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; 2Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim am Rhein, Germany; 3I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation Background/objective: Low back pain affects many patients and has a high socioeconomic impact. Topical capsaicinoids have been used for decades to treat musculoskeletal pain. This study investigated the effects of the fixed dose combination (FDC of nonivamide (a capsaicinoid and nicoboxil (a nicotinic acid ester cream in the treatment of acute nonspecific low back pain.Materials and methods: This phase III randomized, double-blind, placebo-controlled, multinational, multi-center trial investigated efficacy, safety, and tolerability of topical nicoboxil 1.08%/nonivamide 0.17% (Finalgon® cream in treatment of acute nonspecific low back pain with the endpoints: pain intensity (PI difference between pre-dose baseline and 8 hours after first application and the end of treatment, mobility score, and efficacy score.Results: Patients (n=138, 21–65 years of age, were treated for up to 4 days with FDC or placebo cream. Mean baseline PI was 6.8 on a 0–10 point numerical rating scale. After 8 hours, pain was more reduced with the FDC than with placebo (adjusted means: 2.824 vs. 0.975 points; p<0.0001. On the last treatment day, mean pain reduction by the FDC was stronger than with placebo (adjusted means: 5.132 vs. 2.174 points; p<0.0001. Mobility on Day 1 was in favor of the FDC when compared to placebo (odds ratio [95% confidence interval {CI}]: 7.200 [3.609, 14.363], p<0.0001. At the end of treatment, patients treated with the FDC rated efficacy significantly higher than placebo (odds ratio [95% CI]: 11.370 [5.342, 24.199], p<0.0001. Both treatments were tolerated well. No serious adverse events were reported.Conclusion: Nicoboxil

  8. 48 CFR 15.408 - Solicitation provisions and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... incentive contract is contemplated; or (2) Its Alternate II, if a cost-plus-incentive-fee contract is contemplated. (b) Price Reduction for Defective Certified Cost or Pricing Data. The contracting officer shall... Certified Cost or Pricing Data, in solicitations and contracts when it is contemplated that certified cost...

  9. Availability and affordability of blood pressure-lowering medicines and the effect on blood pressure control in high-income, middle-income, and low-income countries: an analysis of the PURE study data

    Directory of Open Access Journals (Sweden)

    Marjan W Attaei, MA

    2017-09-01

    Funding: Population Health Research Institute, the Canadian Institutes of Health Research, Heart and Stroke Foundation of Ontario, Canadian Institutes of Health Research Strategy for Patient Oriented Research through the Ontario SPOR Support Unit, the Ontario Ministry of Health and Long-Term Care, pharmaceutical companies (with major contributions from AstraZeneca [Canada], Sanofi Aventis [France and Canada], Boehringer Ingelheim [Germany amd Canada], Servier, and GlaxoSmithKline, Novartis and King Pharma, and national or local organisations in participating countries.

  10. THE ROLE OF SPASMOLYTIC THERAPY IN THERAPY OF CHRONIC CONSTIPATIONS AMONG CHILDREN

    Directory of Open Access Journals (Sweden)

    A.S. Potapov

    2007-01-01

    Full Text Available The article grounds the application of the spasmolytic therapy in complex treatment of chronic constipations among children by the example of hyoscine butylbromide (buscopan, boehringer ingelheim pharma, germany. favourable impact of the medication on the motoraevacuation function of the large intestine has been proved both clinically and by means of functional and ultrasonic methods of the large intestine examination. Good tolerance of the medication allows for its application in pediatric practice.Key words: children, chronic constipation, diagnostics, treatment, hyoscine butylbromide.

  11. What factors hinder the decision-making process for women with cancer and contemplating fertility preservation treatment?

    Science.gov (United States)

    Jones, Georgina; Hughes, Jane; Mahmoodi, Neda; Smith, Emily; Skull, Jonathan; Ledger, William

    2017-07-01

    Although fertility preservation (FP) treatment options have increased, the existing evidence suggests that many women with cancer do not feel well supported in making these decisions, but find them stressful and complex and fail to take up fertility care at this crucial time. Whilst existing reviews have all made important contributions to our understanding of the FP decision-making process, none of them examine solely and specifically these processes for women of reproductive age with a diagnosis of any cancer, leaving a gap in the knowledge base. Given the expectation that care is patient-centred, our review aims to address this gap which may be of help to those managing patients struggling to make difficult decisions in the often brief period before potentially sterilizing cancer treatment is started. Underpinning this narrative review was the question 'What factors hinder the decision-making process for women with any cancer and contemplating FP treatment?' Our objectives were to (i) assess and summarize this existing literature, (ii) identify the factors that hinder this decision-making process, (iii) explore to what extent these factors may differ for women choosing different methods of FP and (iv) make recommendations for service delivery and future research. A systematic search of the medical and social science literature from the 1 January 2005 up to the end of January 2016 was carried out using three electronic databases (Web of Science (PubMed), Ovid SP Medline and CINAHL via Ebsco). Included in the review were quantitative, qualitative and mixed-method studies. Reference lists of relevant papers were also hand searched. From the 983 papers identified, 46 papers were included. Quality assessment was undertaken using the Mixed Methods Appraisal Tool and thematic analysis was used to analyse the data. From the analysis, 6 key themes with 15 sub-themes emerged: (i) fertility information provision (lack of information, timing of the information, patient

  12. Comorbidities of patients in tiotropium clinical trials: comparison with observational studies of patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Miravitlles M

    2015-03-01

    Full Text Available Marc Miravitlles,1 David Price,2 Klaus F Rabe,3,7 Hendrik Schmidt,4 Norbert Metzdorf,5 Bartolome Celli6 1Pneumology Department, Hospital Universitari Vall d’Hebron, Ciber de Enfermedades Respiratorias (CIBERES, Barcelona, Spain; 2Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK; 3Department of Medicine, Christian-Albrechts-Universität zu Kiel (CAU, Großhansdorf, Germany; 4Global Biometrics and Clinical Applications, Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim am Rhein, Germany; 5TA Respiratory Diseases, Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim am Rhein, Germany; 6Pulmonary Division, Brigham and Women’s Hospital, Boston, MA, USA; 7LungenClinic Grosshansdorf, Großhansdorf, Germany Background: There is an ongoing debate on whether patients with chronic obstructive pulmonary disease (COPD seen in real-life clinical settings are represented in randomized controlled trials (RCTs of COPD. It is thought that the stringent inclusion and exclusion criteria of RCTs may prevent the participation of patients with specific characteristics or risk factors.Methods: We surveyed a database of patients recruited into 35 placebo-controlled tiotropium RCTs and also conducted a systematic literature review of large-scale observational studies conducted in patients with a documented diagnosis of COPD between 1990 and 2013. Patient demographics and comorbidities with a high prevalence in patients with COPD were compared between the two patient populations at baseline. Using the Medical Dictionary for Regulatory Activities (MedDRA; v 14.0, patient comorbidities in the pooled tiotropium RCTs were classified according to system organ class, pharmacovigilance (PV endpoints, and Standardised MedDRA Queries to enable comparison with the observational studies.Results: We identified 24,555 patients in the pooled tiotropium RCTs and 61,361 patients among the 13 observational studies that met our

  13. contemplating allan boesak's fascination with preaching

    African Journals Online (AJOL)

    ... there is not always sufficient emphasis upon ... how that Word can become a living ... democracy, we can get a picture of how political power is structured. With ... South African society, there seem to be no prospects for a better future other than ..... own transgressions and we don't remember our own sins and we miss the ...

  14. Contemplation and Calculation: The Universe Discovered.

    Science.gov (United States)

    Solovyov, Yury

    1992-01-01

    Discusses how early notions about celestial mechanics were restructured, one by one, involving the following concepts: the celestial sphere and its rotation; the spherical earth; planetary motion; and models for the solar system initiated by Eudoxus, Hipparchus, Ptolemy, and Copernicus. (JJK)

  15. Daily home-based spirometry during withdrawal of inhaled corticosteroid in severe to very severe chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Rodriguez-Roisin R

    2016-08-01

    Full Text Available Roberto Rodriguez-Roisin,1 Kay Tetzlaff,2,3 Henrik Watz,4 Emiel FM Wouters,5 Bernd Disse,2 Helen Finnigan,6 Helgo Magnussen,4 Peter MA Calverley7 1Respiratory Institute, Servei de Pneumologia, Hospital Clínic IDIBAPS-CIBERES, Universitat de Barcelona, Barcelona, Spain; 2Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany; 3Department of Sports Medicine, University of Tübingen, Tübingen, Germany; 4Pulmonary Research Institute at Lung Clinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany; 5Department of Respiratory Medicine, University Hospital Maastricht, Maastricht University, Maastricht, the Netherlands; 6Department of Biostatistics and Data Sciences, Boehringer Ingelheim, Bracknell, UK; 7Institute of Ageing and Chronic Disease, Aintree University Hospital, Liverpool, UK Abstract: The WISDOM study (NCT00975195 reported a change in lung function following withdrawal of fluticasone propionate in patients with severe to very severe COPD treated with tiotropium and salmeterol. However, little is known about the validity of home-based spirometry measurements of lung function in COPD. Therefore, as part of this study, following suitable training, patients recorded daily home-based spirometry measurements in addition to undergoing periodic in-clinic spirometric testing throughout the study duration. We subsequently determined the validity of home-based spirometry for detecting changes in lung function by comparing in-clinic and home-based forced expiratory volume in 1 second in patients who underwent stepwise fluticasone propionate withdrawal over 12 weeks versus patients remaining on fluticasone propionate for 52 weeks. Bland–Altman analysis of these data confirmed good agreement between in-clinic and home-based measurements, both across all visits and at the individual visits at study weeks 6, 12, 18, and 52. There was a measurable difference between the forced expiratory volume

  16. Efficacy and safety of the long-acting β2-agonist olodaterol over 4 weeks in Japanese patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Ichinose M

    2015-08-01

    Full Text Available Masakazu Ichinose,1 Ayako Takizawa,2 Toshiyasu Izumoto,2 Yusuke Tadayasu,2 Alan L Hamilton,3 Christina Kunz,4 Yoshinosuke Fukuchi51Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; 2Nippon Boehringer Ingelheim Co. Ltd, Tokyo, Japan; 3Boehringer Ingelheim, Burlington, Ontario, Canada; 4Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany; 5Juntendo University School of Medicine, Tokyo, JapanBackground: Olodaterol is a novel long-acting β2-agonist with proven ≥24-hour duration of action in preclinical and clinical studies.Objective: This randomized, double-blind, placebo-controlled, parallel-group study evaluated the dose response of once-daily (QD olodaterol based on bronchodilator efficacy, safety, and pharmacokinetics over 4 weeks in Japanese patients with chronic obstructive pulmonary disease (COPD.Methods: All eligible patients were randomized to receive 2 µg, 5 µg, or 10 µg of olodaterol or placebo for 4 weeks via the Respimat® Soft Mist™ inhaler. The primary end point was the change from baseline in trough forced expiratory volume in 1 second (FEV1 after 4 weeks of olodaterol treatment. Secondary end points included trough FEV1 after 1 week and 2 weeks of treatment, FEV1 area under the curve from 0 hour to 3 hours (AUC0–3, peak FEV1 from 0 hour to 3 hours (peak FEV1, and corresponding forced vital capacity (FVC responses. Rescue medication use, COPD symptoms, physician global evaluation, pharmacokinetics, and safety were also assessed.Results: A total of 328 patients with COPD were randomized to receive treatment. All olodaterol doses assessed in the study showed statistically significant increases in trough FEV1 compared to placebo at Day 29 (P<0.0001. Mean increases in peak FEV1 and FEV1 AUC0–3 compared to placebo were also significant (P<0.0001. A clear dose–response relationship was observed across all treatment groups. FVC responses (trough

  17. Treatment of exacerbations as a predictor of subsequent outcomes in patients with COPD

    Directory of Open Access Journals (Sweden)

    Calverley PMA

    2018-04-01

    Full Text Available Peter MA Calverley,1 Antonio R Anzueto,2 Daniel Dusser,3 Achim Mueller,4 Norbert Metzdorf,5 Robert A Wise6 1Clinical Science Centre, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK; 2Pulmonary/Critical Care, University of Texas and South Texas Veterans Health Care System, San Antonio, TX, USA; 3Department of Pneumology, Hôpital Cochin, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; 4Biostatistics and Data Sciences Europe, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany; 5Respiratory Medicine, Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, Germany; 6Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA Rationale: Exacerbations of COPD are managed differently, but whether treatment of one exacerbation predicts the likelihood of subsequent events is unknown. Objective: We examined whether the treatment given for exacerbations predicted subsequent outcomes. Methods: This was a post-hoc analysis of 17,135 patients with COPD from TIOtropium Safety and Performance In Respimat® (TIOSPIR®. Patients treated with tiotropium with one or more moderate to severe exacerbations on study were analyzed using descriptive statistics, logistic and Cox regression analysis, and Kaplan–Meier plots. Results: Of 8,061 patients with moderate to severe exacerbation(s, demographics were similar across patients with exacerbations treated with antibiotics and/or steroids or hospitalization. Exacerbations treated with systemic corticosteroids alone or in combination with antibiotics had the highest risk of subsequent exacerbation (HR: 1.21, P=0.0004 and HR: 1.33, P<0.0001, respectively, and a greater risk of having a hospitalized (severe exacerbation (HR: 1.59 and 1.63, P<0.0001, respectively or death (HR: 1.50, P=0.0059 and HR: 1.47, P=0.0002, respectively compared with exacerbations treated

  18. Blood eosinophil count and exacerbations in severe chronic obstructive pulmonary disease after withdrawal of inhaled corticosteroids

    DEFF Research Database (Denmark)

    Watz, Henrik; Tetzlaff, Kay; Wouters, Emiel F M

    2016-01-01

    were seen with eosinophil cutoffs of 300 cells per μL and 400 cells per μL, and mutually exclusive subgroups. INTERPRETATION: Blood eosinophil counts at screening were related to the exacerbation rate after complete ICS withdrawal in patients with severe to very severe COPD and a history...... of exacerbations. Our data suggest that counts of 4% or greater or 300 cells per μL or more might identify a deleterious effect of ICS withdrawal, an effect not seen in most patients with eosinophil counts below these thresholds. FUNDING: Boehringer Ingelheim....

  19. Bridging two worlds that care about art: psychological and historical approaches to art appreciation.

    Science.gov (United States)

    Thompson, William Forde; Antliff, Mark

    2013-04-01

    Art appreciation often involves contemplation beyond immediate perceptual experience. However, there are challenges to incorporating such processes into a comprehensive theory of art appreciation. Can appreciation be captured in the responses to individual artworks? Can all forms of contemplation be defined? What properties of artworks trigger contemplation? We argue that such questions are fundamental to a psycho-historical framework for the science of art appreciation, and we suggest research that may assist in refining this framework.

  20. 41 CFR 60-3.6 - Use of selection procedures which have not been validated.

    Science.gov (United States)

    2010-07-01

    ... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 3-UNIFORM GUIDELINES ON EMPLOYEE SELECTION PROCEDURES (1978... validation techniques contemplated by these guidelines. In such circumstances, the user should utilize... techniques contemplated by these guidelines usually should be followed if technically feasible. Where the...

  1. Holocene sea level, a semi-empirical contemplation

    Science.gov (United States)

    Bittermann, K.; Kemp, A.; Vermeer, M.; Rahmstorf, S.

    2017-12-01

    Holocene eustatic sea level from approximately -10,000-1800 CE was characterized by an increase of about 60m, with the rate progressively slowing down until sea level almost stabilizes between 500-1800 CE. Global and northern-hemisphere temperatures rose from the last glacial termination until the `Holocene Optimum'. From ­­there, up to the start of the recent anthropogenic rise, they almost steadily decline. How are the sea-level and temperature evolutions linked? We investigate this with semi-empirical sea-level models. We found that, due to the nature of Milankovitch forcing, northern-hemisphere temperature (we used the Greenland temperature by Vinther et al., 2009) is a better model driver than global mean temperature because the evolving mass of northern-hemisphere land ice was the dominant cause of Holocene global sea-level trends. The adjustment timescale for this contribution is 1200 years (900-1500 years; 90% confidence interval). To fit the observed sea-level history, the model requires a small additional constant rate (Bittermann 2016). This rate turns out to be of the same order of magnitude as reconstructions of Antarctic sea-level contributions (Briggs et al. 2014, Golledge et al. 2014). In reality this contribution is unlikely to be constant but rather has a dominant timescale that is large compared to the time considered. We thus propose that Holocene sea level can be described by a linear combination of a temperature driven rate, which becomes negative in the late Holocene (as Northern Hemisphere ice masses are diminished), and a positive, approximately constant term (possibly from Antarctica), which starts to dominate from the middle of the Holocene until the start of industrialization. Bibliography: Bittermann, K. 2016. Semi-empirical sea-level modelling. PhD Thesis University of Potsdam. Briggs, R.D., et al. 2014. A data-constrained large ensemble analysis of Antarctic evolution since the Eemian. Quaternary science reviews, 103, 91-115. Golledge, N.R., et al. 2014. Antarctic contribution to meltwater pulse 1A from reduced Southern Ocean overturning. Nature communications, 5, 5107. Vinther, B.M., et al. 2009. Holocene thinning of the Greenland ice sheet. Nature, 461(7262), 385-388.

  2. A cross-sectional study to assess inhalation device handling and patient satisfaction in COPD

    Directory of Open Access Journals (Sweden)

    Miravitlles M

    2016-02-01

    Full Text Available Marc Miravitlles,1 Jéssica Montero-Caballero,2 Frank Richard,2 Salud Santos,3 Juan Luis Garcia-Rivero,4 Francisco Ortega,5 Xavier Ribera61Pneumology Department, Hospital Universitari Vall d’Hebron, Ciber de Enfermedades Respiratorias (CIBERES, Barcelona, Spain; 2Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim, Germany; 3Pulmonology Department, Hospital Universitari de Bellvitge, IDIBELL, Universitat de Barcelona, Ciber de Enfermedades Respiratorias (CIBERES, Barcelona, Spain; 4Pneumology Department, Hospital de Laredo, Cantabria, Spain; 5Pneumology Department, Hospital Virgen del Rocío, Sevilla, Spain; 6Boehringer Ingelheim Pharma GmbH & Co KG, Barcelona, Spain Abstract: Delivery of inhaled medications via an inhaler device underpins the effectiveness of treatment for patients with chronic obstructive pulmonary disease (COPD. Correct inhaler technique among patients is also a predictor of achieving treatment compliance and adherence. Reporting of patient satisfaction with inhalers is therefore gaining increasing attention and is now recognized as an important patient-reported outcome in clinical trials involving patients with COPD or asthma. In this cross-sectional study, we use the validated Patient Satisfaction and Preference Questionnaire (PASAPQ to assess the handling and satisfaction for Respimat® Soft Mist™ Inhaler (SMI compared with the Breezhaler® dry powder inhaler (DPI among patients with COPD in Spain. Patients were already assigned to therapy with either SPIRIVA® (tiotropium Respimat® or with Hirobriz®/Onbrez®/Oslif® (indacaterol Breezhaler® for at least 3 but not more than 6 months before completing the PASAPQ at a single visit to the study site. The primary endpoint of the trial was the mean total PASAPQ score. Secondary endpoints were the performance score domain of the PASAPQ, the convenience score domain of the PASAPQ, and the overall satisfaction score of the PASAPQ. For the primary endpoint, the mean PASAPQ

  3. Lung function and long-term safety of tiotropium/olodaterol in East Asian patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Bai C

    2017-11-01

    Full Text Available Chunxue Bai,1 Masakazu Ichinose,2 Sang Haak Lee,3 Kwan Ho Lee,4 Olaf Jöns,5 Ulrich Bothner,6 Yihua Zhao,7 Roland Buhl8 1Department of Pulmonary Medicine, Shanghai Respiratory Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China; 2Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; 3Department of Internal Medicine, St Paul’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 4Department of Internal Medicine, Yeungnam University Medical Center, Daegu, South Korea; 5Department of Medicine TA Respiratory Diseases, 6Department of Pharmacovigilance, Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany; 7Department of Biostatistics and Data Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA; 8Pulmonary Department, Mainz University Hospital, Mainz, Germany Background and purpose: While the efficacy and safety of combined tiotropium and olodaterol in patients with COPD was established in a large clinical trial program, it is important to assess whether clinical data can be applied to geographic patient groups, particularly for East Asian patients who may have a different phenotypic profile to the global trial population. This study aimed to compare the lung function and safety profiles of tiotropium/olodaterol and monocomponents in East Asian and global populations from the TONADO® trials.Materials and methods: In the replicate, double-blind, parallel-group, active-controlled, randomized, 52-week, Phase III TONADO studies, patients received tiotropium/olodaterol, tiotropium, or olodaterol. We assessed the forced expiratory volume in 1 second (FEV1 area under the curve from 0 to 3 hours (AUC0–3 response and trough FEV1 response at 24 weeks for the approved doses, tiotropium/olodaterol 5/5 µg, tiotropium 5 µg, and olodaterol 5 µg. Treatment-emergent adverse events were recorded throughout treatment and ≤21 days

  4. 29 CFR 1607.6 - Use of selection procedures which have not been validated.

    Science.gov (United States)

    2010-07-01

    .... 1607.6 Section 1607.6 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY... circumstances in which a user cannot or need not utilize the validation techniques contemplated by these... which has an adverse impact, the validation techniques contemplated by these guidelines usually should...

  5. The subtle body: an interoceptive map of central nervous system function and meditative mind-brain-body integration.

    Science.gov (United States)

    Loizzo, Joseph J

    2016-06-01

    Meditation research has begun to clarify the brain effects and mechanisms of contemplative practices while generating a range of typologies and explanatory models to guide further study. This comparative review explores a neglected area relevant to current research: the validity of a traditional central nervous system (CNS) model that coevolved with the practices most studied today and that provides the first comprehensive neural-based typology and mechanistic framework of contemplative practices. The subtle body model, popularly known as the chakra system from Indian yoga, was and is used as a map of CNS function in traditional Indian and Tibetan medicine, neuropsychiatry, and neuropsychology. The study presented here, based on the Nalanda tradition, shows that the subtle body model can be cross-referenced with modern CNS maps and challenges modern brain maps with its embodied network model of CNS function. It also challenges meditation research by: (1) presenting a more rigorous, neural-based typology of contemplative practices; (2) offering a more refined and complete network model of the mechanisms of contemplative practices; and (3) serving as an embodied, interoceptive neurofeedback aid that is more user friendly and complete than current teaching aids for clinical and practical applications of contemplative practice. © 2016 New York Academy of Sciences.

  6. Kontemplative aktiviteter i skolen i et livsverdensperspektiv

    DEFF Research Database (Denmark)

    Kolmos, Marie

    2016-01-01

    This article deals with how contemplative activities in a public school setting and a Waldorf school setting emerge in a phenomenological inspired life-world perspective. It starts with a short introduction to ‘contemplative activities’ and how they can be understood in connection to school setti...

  7. Reflection on the Role of the Spirit in Finding Meaning and Healing as Clinicians.

    Science.gov (United States)

    Jacobs, Carolyn

    2018-01-01

    Reflections on the Role of the Spirit in Finding Meaning and Healing as Clinicians is based on a presentation for the George Washington Spirituality and Health Summer Institute on July 13, 2017. The presentation invited health care professionals to explore contemplative practices as ways to invite the Spirit to strengthening their resilience in caring for themselves and others. As clinicians, there is often a longing to be grounded in a regular contemplative practice centering one's inner life and to acknowledge the creative energy of the Spirit in relationships. This reflection draws on resilience research that finds that contemplative practices such as deep breathing, meditation, reflective writing, and peer or community support enhance ways of meaning making and healing. Contemplative practices are provided, which can connect clinicians to the Spirit with the purpose of leading to increased meaning and healing in self and relationships. Copyright © 2017 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

  8. Meditation has stronger relationships with mindfulness, kundalini, and mystical experiences than yoga or prayer.

    Science.gov (United States)

    de Castro, John M

    2015-09-01

    Contemplative practices can have profound effects on mindfulness and on physical and sensory and mystical experiences. Individuals who self-reported meditation, yoga, contemplative prayer, or a combination of practices and their patterns of practice were compared for mindfulness, kundalini effects, and mystical experiences. The results suggest that the amount of practice but not the pattern and social conditions of practice influences mindfulness and possibly mystical experiences. Meditation, yoga, contemplative prayer, or a combination of practices all were found to be associated with enhancements of mindfulness, kundalini effects, and mystical experiences, but meditation had particularly strong associations and may be the basis of the associations of yoga and prayer with these outcomes. The results further suggest that the primary association of contemplative practices is with the real time awareness and appreciation of sensory and perceptual experiences which may be the intermediary between disparate practices and mindfulness, kundalini effects, and mystical experiences. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. Compositions and methods related to serotonin 5-HT1A receptors

    Science.gov (United States)

    Mukherjee, Jogeshwar [Irvine, CA; Saigal, Neil [Fresno, CA; Saigal, legal representative, Harsh

    2012-09-25

    Contemplated substituted arylpiperazinyl compounds, and most preferably .sup.18F-Mefway, exhibit desirable in vitro and in vivo binding characteristics to the 5-HT1A receptor. Among other advantageous parameters, contemplated compounds retain high binding affinity, display optimal lipophilicity, and are radiolabeled efficiently with .sup.18F-fluorine in a single step. Still further, contemplated compounds exhibit high target to non-target ratios in receptor-rich regions both in vitro and in vivo, and selected compounds can be effectively and sensitively displaced by serotonin, thus providing a quantitative tool for measuring 5-HT1A receptors and serotonin concentration changes in the living brain.

  10. Music and Music Education: Theory and Praxis for "Making a Difference"

    Science.gov (United States)

    Regelski, Thomas A.

    2005-01-01

    The "music appreciation as contemplation" paradigm of traditional aesthetics and music education assumes that music exists to be contemplated for itself. The resulting distantiation of music and music education from life creates a legitimation crisis for music education. Failing to make a noteworthy musical difference for society, a politics of…

  11. 77 FR 42796 - Privacy Act of 1974; System of Records; Statement of General Routine Uses; Notice of...

    Science.gov (United States)

    2012-07-20

    ... activities against the United States, as contemplated by the Intelligence Reform and Terrorism Prevention Act... functions and activities that gave rise to the system of records. This general use does not contemplate uses that are in addition to those already identified in existing DOT SORNs, instead, it clarifies that DOT...

  12. Living on Borrowed Time: Rethinking Temporality, Self, Nihilism, and Schooling

    Science.gov (United States)

    Rappleye, Jeremy; Komatsu, Hikaru

    2016-01-01

    Seeking to contribute to recent attempts to rethink the deepest foundations of the field, this paper offers news ways of contemplating time, specifically its relations to self, nihilism, and schooling. We briefly review how some leading Western thinkers have contemplated time before detailing Japanese scholars who have offered divergent, original,…

  13. "The molecular basis of aging": the Boehringer Ingelheim Fonds 95th International Titisee Conference.

    Science.gov (United States)

    Garinis, George A; Patil, Christopher K; Schumacher, Björn

    2007-01-01

    Nearly 20 years ago, researchers discovered that lifespan can be extended by single-gene mutations in the nematode worm Caenorhabditis elegans. Further studies revealed that the mechanisms governing aging in the smallest organisms have been evolutionarily conserved and may operate in human beings. Since then, the field of biogerontology has expanded considerably, learning from - and contributing to - such disparate fields as cell signaling, metabolism, endocrinology, and a wide range of human diseases including cancer. To date, newly discovered connections and novel interdisciplinary approaches gradually unify what once seemed unrelated observations between seemingly disparate research areas. While this unification is far from complete, several overlapping themes have clearly emerged. At the 95th International Titisee Conference, devoted to "The Molecular Basis of Aging," 60 of the world's pre-eminent biogerontologists shared their most recent findings in the biology of aging, and discussed interdisciplinary connections between diverse fields.

  14. The impact of data integrity on decision making in early lead discovery

    Science.gov (United States)

    Beck, Bernd; Seeliger, Daniel; Kriegl, Jan M.

    2015-09-01

    Data driven decision making is a key element of today's pharmaceutical research, including early drug discovery. It comprises questions like which target to pursue, which chemical series to pursue, which compound to make next, or which compound to select for advanced profiling and promotion to pre-clinical development. In the following paper we will exemplify how data integrity, i.e. the context data is generated in and auxiliary information that is provided for individual result records, can influence decision making in early lead discovery programs. In addition we will describe some approaches which we pursue at Boehringer Ingelheim to reduce the risk for getting misguided.

  15. Vida ativa, vida contemplativa e filosofia em Avicena

    NARCIS (Netherlands)

    Lizzini, O.L.

    2016-01-01

    Portuguese translation of] “Vie active, vie contemplative et philosophie chez Avicenne in ‘Vie active et vie contemplative au Moyen Age et au seuil de la Renaissance. Études réunies par Ch. Trottmann, École française de Rome, Rome 2009, pp. 207-239], REVISTA ÂYINÉ n. 2, 2016 (Zuane Fabris ed.,

  16. Motivational readiness for active commuting by university students: incentives and barriers.

    Science.gov (United States)

    Cole, Rachel; Leslie, Eva; Donald, Maria; Cerin, Ester; Neller, Anne; Owen, Neville

    2008-12-01

    Walking for transport can contribute significantly to health-enhancing physical activity. We examined the associations of stages of motivational readiness for active transport with perceived barriers and incentives to walking to and from university among students. Mail-back surveys were completed by 781 students in a regional university in south-east Queensland. They identified one of eight options on motivational readiness for active commuting, which were then classified as: pre-contemplation; contemplation-preparation; or, action-maintenance. Open-ended questions were used to identify relevant barriers and incentives. Logistic regressions were used to examine the barriers and incentives that distinguished between those at different stages of motivational readiness. Barriers most frequently reported were long travel distances, inconvenience and time constraints. Incentives most frequently reported were shorter travel distance, having more time, supportive infrastructure and better security. Those not considering active commuting (pre-contemplation) were significantly more likely to report shorter travel distance as an incentive compared to those in contemplation-preparation. Those in contemplation-preparation were significantly more likely to report lack of motivation, inadequate infrastructure, shorter travel distance and inconvenience as barriers; and, having more time, supportive infrastructure, social support and incentive programs as encouragement. Different barriers and incentives to walking to or from university exist for students in the different stages of motivational readiness for active commuting. Interventions targeted specifically to stage of motivational readiness may be potentially helpful in increasing activity levels, through active transport.

  17. Contemplation on Plot and Personification in Tehran Makhuf

    Directory of Open Access Journals (Sweden)

    Mirjalil Akrami

    2013-11-01

    Full Text Available Abstract Story is one of the important and influential literary genres that deserves to research on its structure and content .By study and analysis of a story, the reader could comprehend the textual messages and change his attitude toward life and different issues .After defining of the social novel, the author tries to analyze plot and personification in novel of “Tehran-e- Makhuf” and respond to the questions on the method employed for plot and personification and analyze it from plot and its components such as conflict, suspension and resolution and compare the differences and similarities between old tales and modern novels.  The plot of “Tehran-e- Makhuf” is not so complex due to its subject and content and natural order of events dominates on artificial discipline and it lacks open plot. Of main elements of plot, conflict is more outstanding here. This novel is full of emotional and moral conflicts and there is no similarity with historical novels that describe good and bad conflicts. Cause and effect relationship is main element of plot that shadows on the story events .In “Tehrna-e- Makhuf”, the author tries to violate the principles and cause to imbalance in natural events sequences with discomposing rational and experiential relationship and take action toward artificiality and unnatural suspension. In creating suspension by emphasis on incidences in some extremist cases, Kazemi tries to found the story based on the considerable sequence of events and this conduct reduces quality of the story significantly and leads to imbalance in rational and acceptable discipline.  Kazemi employs direct or reporting personification mostly. This novel lacks diversity in personage considerably .All characters speak in similar style and there is no particular speech style. The personification of Kazemi in “Tehran-e-Makhuf” is continuous and interdependent in style of old tales and novel in European account. In some cases, he approaches to story characters specifications and in other cases, he distances from traditional personification due to familiarity with western countries particularly Russian and French writers .Indeed, it can be said that personification in “Tehran-e- Makhuf” is passing from traditional to modern and western style. The characters of “Tehran-e- Makhuf” are classified in two categories: the first category involves aristocrats and their purpose is power and wealth and prevention of any social shift. They are identified by traits like “reveler”, “hypocrite”, “stingy” and “rich” .The characters like Siyavash Mirza, F.Saltaneh, Shazdeh and Ali Ashraf khan are in this group .The second category is identified by traits like “noble”, “loyal”, “sufferer “ and “patient” and they are common people. Characters like Farrokh, Javad, servant of Farrokh, Mahin and Efat are in this group and they are noble and humanely and good .The main and secondary personages are constant and static in this novel .They attend in the story without changing. All characters introduced by Kazemi in “Tehran-e- Makhuf” are real and they reflect society realities .The characters reflect historical and social realities of particular place and time

  18. Contemplation on Plot and Personification in Tehran Makhuf

    Directory of Open Access Journals (Sweden)

    Mohammad Pashaei

    2013-10-01

    Full Text Available  Abstract Story is one of the important and influential literary genres that deserves to research on its structure and content .By study and analysis of a story, the reader could comprehend the textual messages and change his attitude toward life and different issues .After defining of the social novel, the author tries to analyze plot and personification in novel of “Tehran-e- Makhuf” and respond to the questions on the method employed for plot and personification and analyze it from plot and its components such as conflict, suspension and resolution and compare the differences and similarities between old tales and modern novels.  The plot of “Tehran-e- Makhuf” is not so complex due to its subject and content and natural order of events dominates on artificial discipline and it lacks open plot. Of main elements of plot, conflict is more outstanding here. This novel is full of emotional and moral conflicts and there is no similarity with historical novels that describe good and bad conflicts. Cause and effect relationship is main element of plot that shadows on the story events .In “Tehrna-e- Makhuf”, the author tries to violate the principles and cause to imbalance in natural events sequences with discomposing rational and experiential relationship and take action toward artificiality and unnatural suspension. In creating suspension by emphasis on incidences in some extremist cases, Kazemi tries to found the story based on the considerable sequence of events and this conduct reduces quality of the story significantly and leads to imbalance in rational and acceptable discipline.  Kazemi employs direct or reporting personification mostly. This novel lacks diversity in personage considerably .All characters speak in similar style and there is no particular speech style. The personification of Kazemi in “Tehran-e-Makhuf” is continuous and interdependent in style of old tales and novel in European account. In some cases, he approaches to story characters specifications and in other cases, he distances from traditional personification due to familiarity with western countries particularly Russian and French writers .Indeed, it can be said that personification in “Tehran-e- Makhuf” is passing from traditional to modern and western style. The characters of “Tehran-e- Makhuf” are classified in two categories: the first category involves aristocrats and their purpose is power and wealth and prevention of any social shift. They are identified by traits like “reveler”, “hypocrite”, “stingy” and “rich” .The characters like Siyavash Mirza, F.Saltaneh, Shazdeh and Ali Ashraf khan are in this group .The second category is identified by traits like “noble”, “loyal”, “sufferer “ and “patient” and they are common people. Characters like Farrokh, Javad, servant of Farrokh, Mahin and Efat are in this group and they are noble and humanely and good .The main and secondary personages are constant and static in this novel .They attend in the story without changing. All characters introduced by Kazemi in “Tehran-e- Makhuf” are real and they reflect society realities .The characters reflect historical and social realities of particular place and time

  19. The Idea of the Archipelago: Contemplating Island Relations

    Directory of Open Access Journals (Sweden)

    Elaine Stratford

    2013-05-01

    Full Text Available Creative, innovative, and timely research on islands and island futures is warranted and pressing, not least because island(ers are poorly served by established tropes of them as subordinate to continents or mainlands. Opportunities exist to provide a more thoroughgoing account of island life and island relations, and the seven papers in this special issue address that task. In works that consider islands in the Timor Sea, the Caribbean, the Pacific, Atlantic and Southern Oceans, and that span several different disciplinary frames—archival-historical, critical theoretical, literary, cultural, geopolitical, sociological and artistic—these papers evidence both the diversity of approach to thinking with the archipelago, and numerous points in common. Among the latter is an understanding that island relations are built on connection, assemblage, mobility, and multiplicity, and a commitment to critically examine the ways in which these entanglements affect and give effect to island life. The models of island relationality brought to light by this collective focus on the archipelago reveal new and diverse connections of island peoples with their physical and cultural environments, and with the world beyond; create spaces for growing resilience, association and engagement; and invite further study.

  20. Contemplating Symbolic Literacy of First Year Mathematics Students

    Science.gov (United States)

    Bardini, Caroline; Pierce, Robyn; Vincent, Jill

    2015-01-01

    Analysis of mathematical notations must consider both syntactical aspects of symbols and the underpinning mathematical concept(s) conveyed. We argue that the construct of "syntax template" provides a theoretical framework to analyse undergraduate mathematics students' written solutions, where we have identified several types of…

  1. Contemplating compliance: European compliance mechanisms in international perspective

    NARCIS (Netherlands)

    Koops, C.E.

    2014-01-01

    How can international organizations make their Member States comply with the rules of the organization? Which is the more effective method: to coax and entice, to argue and persuade, or to threaten and punish? On the basis of which criteria should a compliance mechanism be construed and applied,

  2. Electroencephalograph (EEG) study on self-contemplating image formation

    Science.gov (United States)

    Meng, Qinglei; Hong, Elliot; Choa, Fow-Sen

    2016-05-01

    Electroencephalography (EEG) is one of the most widely used electrophysiological monitoring methods and plays a significant role in studies of human brain electrical activities. Default mode network (DMN), is a functional connection of brain regions that are activated while subjects are not in task positive state or not focused on the outside world. In this study, EEG was used for human brain signals recording while all subjects were asked to sit down quietly on a chair with eyes closed and thinking about some parts of their own body, such as left and right hands, left and right ears, lips, nose, and the images of faces that they were familiar with as well as doing some simple mathematical calculation. The time is marker when the image is formed in the subject's mind. By analyzing brain activity maps 300ms right before the time marked instant for each of the 4 wave bands, Delta, Theta, Alpha and Beta waves. We found that for most EEG datasets during this 300ms, Delta wave activity would mostly locate at the frontal lobe or the visual cortex, and the change and movement of activities are slow. Theta wave activity tended to rotate along the edge of cortex either clockwise or counterclockwise. Beta wave behaved like inquiry types of oscillations between any two regions spread over the cortex. Alpha wave activity looks like a mix of the Theta and Beta activities but more close to Theta activity. From the observation we feel that Beta and high Alpha are playing utility role for information inquiry. Theta and low Alpha are likely playing the role of binding and imagination formation in DMN operations.

  3. Contemplations on the further development of nuclear law

    International Nuclear Information System (INIS)

    Mahlmann, W.

    1977-01-01

    Various considerations on the further development of nuclear law are made. The necessity is pointed out to do away with the 'jungle of regulations' and to regain more legal security and transparency in nuclear law. (HP) [de

  4. Contemplation on Plot and Personification in Tehran Makhuf

    OpenAIRE

    Mohammad Pashaei; Mirjalil Akrami; Mirjalil Akrami

    2013-01-01

     Abstract Story is one of the important and influential literary genres that deserves to research on its structure and content .By study and analysis of a story, the reader could comprehend the textual messages and change his attitude toward life and different issues .After defining of the social novel, the author tries to analyze plot and personification in novel of âTehran-e- Makhufâ and respond to the questions on the method employed for plot and personification and analyze it from pl...

  5. Contemplation on Plot and Personification in Tehran Makhuf

    OpenAIRE

    Mirjalil Akrami; Mohammad Pashaei

    2013-01-01

    Abstract Story is one of the important and influential literary genres that deserves to research on its structure and content .By study and analysis of a story, the reader could comprehend the textual messages and change his attitude toward life and different issues .After defining of the social novel, the author tries to analyze plot and personification in novel of “Tehran-e- Makhuf” and respond to the questions on the method employed for plot and personification and analyze it from plot...

  6. Heidegger East and West: Philosophy as Educative Contemplation

    Science.gov (United States)

    Lewin, David

    2015-01-01

    Resonances between Heidegger's philosophy and Eastern religious traditions have been widely discussed by scholars. The significance of Heidegger's thinking for education has also become increasingly clear over recent years. In this article I argue that an important aspect of Heidegger's work, the relevance of which to education is relatively…

  7. David Almond's "Skellig": "A New Vista of Contemplation"?

    Science.gov (United States)

    Stewart, Susan Louise

    2009-01-01

    The debates that have arisen regarding Darwin's theories of evolution and Christian views of creation and their place in education in the United States have frequently been extremely heated, resulting in trials, hearings, and laws. This article provides an overview of some of the disagreements and illustrates how David Almond's British novel,…

  8. Impact and prevention of severe exacerbations of COPD: a review of the evidence

    Directory of Open Access Journals (Sweden)

    Halpin DMG

    2017-10-01

    Full Text Available David MG Halpin,1 Marc Miravitlles,2 Norbert Metzdorf,3 Bartolomé Celli4 1Department of Respiratory Medicine, Royal Devon and Exeter Hospital, Exeter, UK; 2Pneumology Department, Hospital Universitari Vall d’Hebron, CIBER de Enfermedades Respiratorias (CIBERES, Barcelona, Spain; 3Respiratory Medicine, Boehringer Ingelheim Pharma GmBH & Co KG, Ingelheim am Rhein, Germany; 4Pulmonary Division, Brigham and Women’s Hospital, Boston, MA, USA Abstract: Severe exacerbations of COPD, ie, those leading to hospitalization, have profound clinical implications for patients and significant economic consequences for society. The prevalence and burden of severe COPD exacerbations remain high, despite recognition of the importance of exacerbation prevention and the availability of new treatment options. Severe COPD exacerbations are associated with high mortality, have negative impact on quality of life, are linked to cardiovascular complications, and are a significant burden on the health-care system. This review identified risk factors that contribute to the development of severe exacerbations, treatment options (bronchodilators, antibiotics, corticosteroids [CSs], oxygen therapy, and ventilator support to manage severe exacerbations, and strategies to prevent readmission to hospital. Risk factors that are amenable to change have been highlighted. A number of bronchodilators have demonstrated successful reduction in risk of severe exacerbations, including long-acting muscarinic antagonist or long-acting β2-agonist mono- or combination therapies, in addition to vaccination, mucolytic and antibiotic therapy, and nonpharmacological interventions, such as pulmonary rehabilitation. Recognition of the importance of severe exacerbations is an essential step in improving outcomes for patients with COPD. Evidence-based approaches to prevent and manage severe exacerbations should be implemented as part of targeted strategies for disease management. Keywords

  9. COPD depicted – patients drawing their lungs

    Directory of Open Access Journals (Sweden)

    Kaptein AA

    2017-11-01

    Full Text Available Ad A Kaptein,1 Jitske Tiemensma,2 Elizabeth Broadbent,3 Guus M Asijee,4,5 Maarten Voorhaar4,5 1Medical Psychology, Leiden University Medical Centre (LUMC, Leiden, the Netherlands; 2Psychological Sciences, University of California, Merced, CA, USA; 3Psychology Department, Auckland University Medical School, Auckland, New Zealand; 4CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, the Netherlands; 5Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, Germany Background: Given the increasing importance of patient-reported outcomes (PRO in quality medical care, we examined the value and feasibility of an innovative method for assessing patients’ illness perceptions, represented in drawings made by patients with COPD of their lungs. Aim: The aim of our study was: to study patients’ representation of COPD as reflected in their drawings of their lungs; and to examine scores on a validated measure that assesses illness perceptions (ie, Brief Illness Perception Questionnaire [B-IPQ]. Patients and methods: One hundred outpatients with COPD, mean age 70 years, selected from a pharmacy database, participated and 98 filled out the B-IPQ. Eighty-seven patients completed the drawing task. Results: The illness perceptions as reflected in the responses to the B-IPQ scales represented a quite optimistic view of COPD and its consequences. The drawings of the lungs reflected a considerable discordance between patients’ representations and medically accepted representations of lungs of a person with COPD. Conclusion: Assessing illness perceptions in clinical care and research about COPD offers opportunities to identify goals for patient education and self-management. Inviting patients to draw their illness is an innovative and promising approach to assessing PRO. Keywords: COPD, drawings, illness perceptions, PRO, quality of life, self-management

  10. A Comparative Pharmacokinetics Study of the Anti-Parkinsonian Drug Pramipexole

    Directory of Open Access Journals (Sweden)

    Ratih S. I. Putri

    2016-11-01

    Full Text Available The present study aimed to compare pharmacokinetic parameters of two pramipexole 0.25 mg formulations in order to show bioequivalence. The study was conducted in a randomized, open-label, two-period, two-sequence, and crossover design, involving 23 healthy volunteers. One of the 0.25 mg formulations of pramipexole evaluated in the study was manufactured by PT Dexa Medica, Palembang, Indonesia, the other, used as the reference, by Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, Germany. All eligible subjects were required to fast before each drug administration period, which was separated by a one-week washout period. Pramipexole concentrations in plasma were assayed using a validated ultra performance liquid chromatography with mass spectrometry (UPLC-MS/MS detector. The evaluated pharmacokinetic parameters included the area under the plasma concentration curve from time zero to the last observed measurable concentration (AUC0-t, the area under the plasma concentration curve extrapolated to infinite time (AUC0-∞, the maximum plasma concentration (Cmax, the time to reach Cmax (tmax, and the plasma concentration half-life (t1/2. To evaluate the bioequivalence of those two pramipexole formulations, 90% confidence intervals (CIs for geometric mean ratios of both formulations were calculated for AUC and Cmax parameters, while tmax and t1/2 differences were analyzed on the non-transformed data using Wilcoxon matched-pairs and a Student’s paired t-test, respectively. The 90% CIs for the geometric mean ratios of the two pramipexole formulations were 95.89% (90.73%–101.34%, 95.53% (89.75%–101.68%, and 92.11% (84.35%–100.58% for AUC0-t, AUC0-∞, and Cmax, respectively. There were no statistically significant differences for tmax and t1/2 between the two pramipexole formulations. It is concluded that two pramipexole formulations in this study were bioequivalent.

  11. A Comparative Pharmacokinetics Study of the Anti-Parkinsonian Drug Pramipexole.

    Science.gov (United States)

    Putri, Ratih S I; Setiawati, Effi; Aziswan, Syifa A; Ong, Fenny; Tjandrawinata, Raymond R; Susanto, Liana W

    2016-11-18

    The present study aimed to compare pharmacokinetic parameters of two pramipexole 0.25 mg formulations in order to show bioequivalence. The study was conducted in a randomized, open-label, two-period, two-sequence, and crossover design, involving 23 healthy volunteers. One of the 0.25 mg formulations of pramipexole evaluated in the study was manufactured by PT Dexa Medica, Palembang, Indonesia, the other, used as the reference, by Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, Germany. All eligible subjects were required to fast before each drug administration period, which was separated by a one-week washout period. Pramipexole concentrations in plasma were assayed using a validated ultra performance liquid chromatography with mass spectrometry (UPLC-MS/MS) detector. The evaluated pharmacokinetic parameters included the area under the plasma concentration curve from time zero to the last observed measurable concentration (AUC 0-t ), the area under the plasma concentration curve extrapolated to infinite time (AUC 0-∞ ), the maximum plasma concentration (C max ), the time to reach C max (t max ), and the plasma concentration half-life (t 1/2 ). To evaluate the bioequivalence of those two pramipexole formulations, 90% confidence intervals (CIs) for geometric mean ratios of both formulations were calculated for AUC and C max parameters, while t max and t 1/2 differences were analyzed on the non-transformed data using Wilcoxon matched-pairs and a Student's paired t -test, respectively. The 90% CIs for the geometric mean ratios of the two pramipexole formulations were 95.89% (90.73%-101.34%), 95.53% (89.75%-101.68%), and 92.11% (84.35%-100.58%) for AUC 0-t , AUC 0-∞ , and C max , respectively. There were no statistically significant differences for t max and t 1/2 between the two pramipexole formulations. It is concluded that two pramipexole formulations in this study were bioequivalent.

  12. Epidemiology of chronic obstructive pulmonary disease: a literature review

    Directory of Open Access Journals (Sweden)

    Rycroft CE

    2012-07-01

    Full Text Available Catherine E Rycroft,1 Anne Heyes,1 Lee Lanza,2 Karin Becker31Market Access and Outcomes Strategy, RTI Health Solutions, Manchester, United Kingdom; 2Epidemiology, RTI Health Solutions, Waltham, MA, USA; 3Global Health Economics and Outcomes Research, Boehringer Ingelheim GmbH, Ingelheim, GermanyAbstract: The aim of this study is to quantify the burden of chronic obstructive pulmonary disease (COPD – incidence, prevalence, and mortality – and identify trends in Australia, Canada, France, Germany, Italy, Japan, The Netherlands, Spain, Sweden, the United Kingdom, and the United States of America. A structured literature search was performed (January 2000 to September 2010 of PubMed and EMBASE, identifying English-language articles reporting COPD prevalence, incidence, or mortality. Of 2838 articles identified, 299 full-text articles were reviewed, and data were extracted from 133 publications. Prevalence data were extracted from 80 articles, incidence data from 15 articles, and mortality data from 58 articles. Prevalence ranged from 0.2%–37%, but varied widely across countries and populations, and by COPD diagnosis and classification methods. Prevalence and incidence were greatest in men and those aged 75 years and older. Mortality ranged from 3–111 deaths per 100,000 population. Mortality increased in the last 30–40 years; more recently, mortality decreased in men in several countries, while increasing or stabilizing in women. Although COPD mortality increased over time, rates declined more recently, likely indicating improvements in COPD management. In many countries, COPD mortality has increased in women but decreased in men. This may be explained by differences in smoking patterns and a greater vulnerability in women to the adverse effects of smoking.Keywords: COPD, incidence, literature review, mortality, prevalence

  13. El nombre Al ŶamīI y la Presencia de la Belleza

    Directory of Open Access Journals (Sweden)

    Pablo Beneito

    2013-11-01

    Full Text Available Beauty, according to Ibn Arabi, is pronounced to men in two ways: on one hand, by the elevation and power of the divine presence, named Majesty of Beauty, which we must respond through a spiritual state of privacy to accomplish balance during both contemplation and a correct apprehension; on the other hand, through proximity, aspect of Beauty, that should be received with fear for a proper response to God's expansion towards us, achieving in consequence, our gathering with Him. Those who love because of the divine love, contemplate the wisdom echoed in both: the universe as well as in themselves. Ibn Arabi also explained the application of these names to the reading of the Koran. The Prophet sustained the importance of spiritual embellishment achieved by a correct conduct and the contemplation of Beauty, this last one characterized by making all things likable and knowledgeable. Everything is inclined to be self loved, but this is only possible because of Reality's divinity; since God created the world to His image, it is considered as a mirror in which He contemplates and loves Himself.

  14. Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung (LUX-Lung 8)

    DEFF Research Database (Denmark)

    Soria, Jean-Charles; Felip, Enriqueta; Cobo, Manuel

    2015-01-01

    BACKGROUND: There is a major unmet need for effective treatments in patients with squamous cell carcinoma of the lung. LUX-Lung 8 compared afatinib (an irreversible ErbB family blocker) with erlotinib (a reversible EGFR tyrosine kinase inhibitor), as second-line treatment for patients with advanced...... squamous cell carcinoma of the lung. METHODS: We did this open-label, phase 3 randomised controlled trial at 183 cancer centres in 23 countries worldwide. We enrolled adults with stage IIIB or IV squamous cell carcinoma of the lung who had progressed after at least four cycles of platinum...... be an additional option for the treatment of patients with squamous cell carcinoma of the lung. FUNDING: Boehringer Ingelheim....

  15. Silence and the Audibility of the Word: Contemplative Listening as a Fundamental Act of the New Evangelization. Part 2: Jesus Christ, the Eternal Listener

    Directory of Open Access Journals (Sweden)

    J. Marianne Siegmund

    2018-03-01

    Full Text Available In the second part of her arguing for contemplative listening as a fundamental act of the new evangelization, the author turns to the theological perspective of Jesus Christ as the eternal Listener and, thus, focuses upon his act of listening, which is the unique per-sonal form of his eternal divinity. The author addresses the following issues. Granted that listening has to do with obedi-ent readiness, how can one say it is in the eternal Son, who, being God, would seem to be naturally exempt from obedience? In order to answer this question, the author looks at the Balthasarian “enfleshment” of Thomas’ notion of the divine persons as subsistent relations. In brief, to say that the Son is the subsistent relation of sonship means that the Son receives himself from the Father. But this self-reception implies, the author argues, an obedient readiness. And, since the Son is Word, this obedient readiness translates into a “listening.” The Son is not only the eternal Word. He is also the eternal listener of the Word he is. Within the Godhead, each person is his relation (of “opposition” to the others and there is no difference between the person and his action. For example, the Son is his relation of sonship to the Father. But, one might ask, how could one speak of the Son’s obedi-ence? How does one avoid subordinationism? The key is to see how the Son’s posses-sion of divinity is compatible with a reception of it. If the Father is the “source and origin of all divinity,” the Son does, in fact, receive his divinity from the Father while, at the same time, he is co-equal and co-eternal with the Father. That the Father gener-ates the Son does not mean, as Arius asserted, that there was a time when the Son was not. Rather, the Son always possesses his divine sonship as being given from the Fa-ther, while the Father possesses divinity as being given away. Divinity is compatible with relationality in the mode of reception. In the

  16. Estrategias de comunicación publicitaria como respuesta a la crisis económica en España: Coca-Cola como caso de estudio

    OpenAIRE

    González Oñate, Cristina

    2015-01-01

    Inside the communication corporate, the Social Responsibility of the companies has earned a big importance constituting part of the basic point of the business strategies. And is in the advertising communication where more are contemplating this phenomenon: the messages constitute the most important core to the hour to contemplate the strategies because it is where truly finds the efficiency advertising. The advertising market is suffering deep changes that reflect the input of society in...

  17. Belewing as faset van dissipline

    OpenAIRE

    2014-01-01

    M.Ed. (Educational Psychology) This study is part of a broader research project that deals with: The perceptions of the importance of the different aspects of discipline when contemplating disciplinary actions toward children. Ten aspects are incorporated under the above mentioned project. The aim of this specific study is to discover by means of theoretical and empirical research how important teachers and parents deem the perceiving aspect of discipline when contemplating disciplinary ac...

  18. 舞踊享受の構造に関する研究 : マルティン・ブーバーの理論に依拠して

    OpenAIRE

    内山, 須美子; 内山, 治樹

    1990-01-01

    One should strictly choose proper technical terms in a study. Judging from the present conditions, however, the meaning of the terms, "dance-appreciation" and "dance-contemplation"in a dance study is very ambiguous as there is no common understanding among scholars. With an assumption, that the term "dance-enjoyment" includes both "dance-appreciation" and "dance-contemplation", we aimed at to clarify the structure of "dance-enjoyment" through examining the two conceptions, "dance-appreciation...

  19. An industry update: the latest developments in Therapeutic delivery.

    Science.gov (United States)

    Steinbach, Oliver C

    2018-05-01

    The present industry update covers the period of 1 January-31 January 2018, with information sourced from company press releases, regulatory and patent agencies as well as scientific literature. Several public offerings (Gecko, Insmed), licensing (Foresee) and commercialization agreements (Alnylam, Collegium Pharmaceutical) as well as patent filings (Elute) continue to prove the sustained investments in the drug delivery market. In increasing numbers, more effective ways to deliver the active ingredient to the right location and the right dose through devices (Boehringer Ingelheim's Respimat, Medtronics' SynchroMedII) or improved compound properties through formulation (Aquestive Therapeutics' PharmFilm, Noven Pharmaceuticals' transdermal patch) are reaching the market. Furthering biologics and gene delivery (Avacta, Bracco) proves that novel drug delivery technologies are successfully addressing more challenging drug formats.

  20. Self-esteem and alcohol dependence as predictors of contemplation ...

    African Journals Online (AJOL)

    PROMOTING ACCESS TO AFRICAN RESEARCH ... Self-esteem was measured by Rosenberg's self-esteem scale, and alcohol dependence was ... Binary logistic regression analysis revealed that an increase in self-esteem decreased the ...

  1. The Contemplative Life and the Teaching of the Humanities

    Science.gov (United States)

    Stock, Brian

    2006-01-01

    Meditation nowadays plays a part in mind/body medicine and in some branches of educational psychology. In ancient and medieval times, these functions formed a part of the humanities curriculum as it was taught in philosophical schools, monastic communities, and universities. This article claims that it is by returning to a holistic view of the…

  2. Contemplation of wheat genotypes for enhanced antioxidant enzyme activity

    International Nuclear Information System (INIS)

    Nasim, S.; Shabbir, G.; Ilyas, M.

    2017-01-01

    Wheat (Triticum aestivum L.) is leading cereal crop in Pakistan but its yield is highly affected due to various abiotic factors especially drought stress, which affects the metabolism of plants. The present study was conducted at Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, using thirty three genotypes during 2011 to investigate the response of anti oxidative enzymes. Seedlings were subjected to stress condition with 30 % PEG 6000 solution along with control (irrigated with water) under in vitro conditions. The experiment was conducted in pots following Complete Randomized Design in Laboratory. Results revealed that under control conditions the maximum values for Guaiacol peroxidase were found in Punjab-96 and Auqab-2000 (2.523), for superoxide in C-273 (0.294), for ascorbate peroxide in PAK-81 (2.523) and for catalase in Kohsar-95 (0.487). Under moisture stress condition the maximum value for Guaiacol peroxidase were recorded for Kohsar-95 (2.699), for superoxide in Kohsar-95 (1.259), for ascorbate peroxide in Pak-81, SA-75, Mexipak-65 and PARI-73 (3.000) and for catalase in Mexipak-65 (0.640). The genotypes which showed higher antioxidant enzyme activity under drought stress have the ability to perform better under adverse soil moisture condition. Such potential genotypes can be utilized in the future breeding programs and also in improving the wheat varieties against drought stress. (author)

  3. A Trans-Theoretical Approach to Physical Activity Profile in General Population of Mashhad

    Science.gov (United States)

    Shaye, Zahra Abbasi; Bazzaz, Mojtaba Mousavi; Vakili, Veda

    2015-01-01

    Regular physical-activity is necessity for a healthy lifestyle. Despite public health efforts, a minority of population are involved in healthy levels of physical-activity. This study provides evidence about exercise patterns and predictors of Mashhad-Iran population according to TTM change stages. In this cross-sectional study, we surveyed a total number of 564 participants from Mashhad in 2014 by using stages of change questionnaire. Analysis showed 23.4% of participants were in pre-contemplation stage, 18 in contemplation, 24.6% in preparation, 8.10% in action, 14.4% in maintenance and 11.5% were in termination phase. Age, gender, BMI, alcohol consumption, sleep duration, having compeer and encouragement were identified as predictors of pre-contemplation stage. Genders, having company and using bicycle for transportation were predictors of termination phase. Tailor interventions based on the predictors to enhance the physical activity among specific subgroups would be of interest. PMID:26153203

  4. Taking on the Persona of a Suicide Bomber: a Thought Experiment 

    Directory of Open Access Journals (Sweden)

    Anne Speckhard

    2012-05-01

    Full Text Available Nineteen university students experimented taking on the persona of an apprehended suicide bomber.  The role play explored the psychological mechanisms of dissociative phenomena, euphoria or a sense of empowerment contemplating suicide bombing; responses of imagined secondary traumatization; identification with the victim group; creation of fictive kin; choosing the (imagined target; and their (imagined moral reasoning.  Results were eerily similar to accounts of real (failed suicide bombers. Subjects identified with secondary trauma and fictive kin; and reported revenge and justice seeking as motivators; dissociation, some having experiences of euphoria or empowerment when contemplating strapping on a bomb. Their moral reasoning was nearly identical with the one of suicide bombers, despite none of them being Muslim. Most imagined targeting children or civilians. This leads us to the tentative conclusion that psychological mechanisms underlying the contemplation to engage in suicide terrorism may be universal. 

  5. Stages of Behavior Change for physical activity and associated factors among technicaladministrative servers of a federal university

    Directory of Open Access Journals (Sweden)

    Juliane Berria

    2016-09-01

    Full Text Available DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n4p471   The benefits that the regular practice of physical activity (PA provides to health and its importance in preventing and fighting chronic diseases. The aim of this study was to identify the Stages of Behavior Change (SBC for PA among technicaladministrative servers and its association with sociodemographic and health risk factors. This cross-sectional study investigated 622 technical-administrative servers (337 women from a Brazilian federal university. SBC for PA, sociodemographic information (gender, age, marital status and educational level and health risk factors (inadequate eating habits, excessive alcohol consumption, smoking, commuting and PA at work were collected through questionnaires. Multinomial regression with adjustment for the hierarchical level was applied and significance level of 5% was adopted. The distribution of technical-administrative servers in SBC for PA identified prevalence of 9.1% and 6.5% in the pre-contemplation stage, 24.6% and 33.5% in contemplation, 33.3% and 22 6% in preparation, 5.6% and 12.2% in action and 27.4% and 25.2% in maintenance stages between men and women, respectively. Lower odds ratio of being in the preparation stage was identified among women (OR=0.62; CI95%=0.41; 0.93 while those with inadequate eating habits were more odds to be in the “pre-contemplation + contemplation” (OR=2.77; CI95%=1.85; 4.15 and preparation stages (OR=1.75; CI95%=1.12; 2.70. Over 60% of technical-administrative servers are insufficiently active (pre-contemplation, contemplation and preparation stages and factors associated with SBC were female sex and inadequate eating habits.

  6. Image-robot coupling for the prostate brachytherapy

    International Nuclear Information System (INIS)

    Coelen, V.; Lartigau, E.; Merzouki, R.

    2009-01-01

    The results allows to contemplate a robot use in the prostate brachytherapy but equally in other applications such prostate biopsy. The tests to come are going to be directed towards on the use of a prostate phantom in order to calibrate the ultrasonography. thereafter, we contemplate the conception of an intelligent gripping system placed on the robot arm and allowing a good control in closed loop of the brachytherapy needle placement and allowing the setting up of an online monitoring. (N.C.)

  7. Patient education programmes in obstructive airway disease. The Ingelheim Model for promoting health through patient education.

    Science.gov (United States)

    Klein, K; Troglauer, K G; Ahlstich, G; Schunke, B; Theissen, E; Voss, H W; Clausen, V

    1992-06-01

    Chronic obstructive airway diseases (COAD) can be regarded as one of the major health problems needing environmental actions and screening programs for early detection and intensive patient education programs to cope with the needs of tertiary prevention. On the basis of our epidemiological study focused on COAD carried out in FRG (sample size August 1988: 63,000 participants) a patient education program has been developed and evaluated. In cooperation with general practitioners and pneumologists the program has been installed at practice and community level. The need for a patient education program has been assessed during the three years of the PNEUMOBIL-Project. It is not just a matter of cutting costs, but to a large extent a matter of the wellbeing of the patients and of reducing side effects to a minimum. The objective of the project can be split into three dimensions: (1) The cognitive aspect. Here significant lack of knowledge has to be overcome. At this point it has to be stated clearly that at the present time the medical community is not able to solve this problem on their own. (2) The psychomotoric aspect. Here the competent use of medication has to be trained. (3) The emotional aspect. The patient has to be motivated and integrated into the therapeutic process in a way that his compliance contributes significantly. The didactical concept consists of modules that can be used in varying sequences according to the needs of the target audience.(ABSTRACT TRUNCATED AT 250 WORDS)

  8. To play is necessary

    Directory of Open Access Journals (Sweden)

    Angela Vargas

    2008-05-01

    Full Text Available This work tries to contemplate on playing, leaving of the observations on the children's games accomplished during the apprenticeship and the articulation of those with some theoretical ones that have been dedicating if to the study of the game, of the childhood and of the Infantile Education. It was possible, through the apprenticeship registrations and of the observations to live many moments in that the two groups, 3A and 3B, they played incorporating objects and creating characters in your games. He/she gave way, we sought focar the game of the do-of-bill, contemplating on your importance for the children in the first childhood, and that possibilities she brings us in the amplification of the infantile experiences. Another important aspect in this article is to contemplate on the teacher's practice in the Infantile Education, and, through our observations on playing of the children noticed the teachers' involvement in the children's games.

  9. Stages of change in physical activity-related behavior in adolescents from a Brazilian state capital

    Directory of Open Access Journals (Sweden)

    Andreia Pelegrini

    2013-12-01

    Full Text Available The purpose of this study was to investigate the stages of change in physical activity-related behavior (EMCRAF and their association with gender and age. A total of 1108 high school students of both sexes, from Florianópolis, State of Santa Catarina, took part in this study. A questionnaire was used to assess EMCRAF. A higher proportion of boys were in the maintenance stage (48.1% and a higher proportion of girls were in contemplation (24.7% and pre-contemplation (6.4% stages. Gender factor male and age range 17-18 were protective factors, which increased the likelihood of physically active behavior. Girls aged 17-18 were twice as likely to be in the contemplation stage than boys. It is important to expand knowledge about EMCRAF in adolescents and their associations with gender and age because a considerable number of behaviors established during this period of life can last into adulthood.

  10. Budget Impact Analysis of Afatinib for First-Line Treatment of Patients with Metastatic Non-Small Cell Lung Cancer with Epidermal Growth Factor Receptor Exon 19 Deletions or Exon 21 Substitution Mutations in a U.S. Health Plan.

    Science.gov (United States)

    Graham, Jonathan; Earnshaw, Stephanie; Burslem, Kate; Lim, Jonathan

    2018-06-01

    to be $1,606, $65,542, $140,564, $209,272, and $303,368, respectively. These budget increases translated to per-member-per-month increases ranging from $0.00 to $0.03 in years 1 to 5. The increase in afatinib use resulted in the proportion of the treated population (134 patients treated over 5 years) remaining in progression-free disease increasing from 23.7% to 26.2% at the end of year 5, versus if afatinib treatment share had stayed constant. Increasing the treatment share of afatinib in a health plan for the first-line treatment of NSCLC with EGFR del19 or L858R mutations was estimated to increase the proportion of treated patients remaining in progression-free disease, while having small budget impact to the health plan. Boehringer Ingelheim Pharmaceuticals funded this study research and was involved in all stages of study conduct, including the analysis of data, and also undertook all costs associated with the development and publication of this manuscript. Graham and Earnshaw are employees of RTI Health Solutions, an independent contract research organization that has received research funding for this and other studies from Boehringer Ingelheim Pharmaceuticals. Lim and Burslem are employees of Boehringer Ingelheim Pharmaceuticals, which developed and produces afatinib, along with other pharmaceutical products.

  11. Primary Nonadherence to Oral Anticoagulants in Patients with Atrial Fibrillation: Real-World Data from a Population-Based Cohort.

    Science.gov (United States)

    Rodriguez-Bernal, Clara L; Peiró, Salvador; Hurtado, Isabel; García-Sempere, Aníbal; Sanfélix-Gimeno, Gabriel

    2018-05-01

    ) from the Valencia Ministry of Health and Boehringer Ingelheim, a nonconditioned program to conduct independent research in chronic health care, pharmacoepidemiology, and medical practice variation. Rodriguez-Bernal was funded by the Instituto de Salud Carlos III, Spanish Ministry of Health, and cofinanced by the European Regional Development Fund (grant number RD12/0001/0005). The views presented here are those of the authors and not necessarily those of the FISABIO Foundation, the Valencia Ministry of Health, or the study sponsors. The funding sources had no access to study data and did not participate in any way in the design or conduct of the study, data analysis, decisions regarding the dissemination of findings, the development of the manuscript, or its publication. Peiró has received fees for participation in scientific meetings and courses sponsored by Novartis and Ferrer International. In 2014, Sanfélix-Gimeno participated in an advisory meeting of Boehringer Ingelheim. García-Sempere is a former employee of Boehringer Ingelheim. Rodriguez-Bernal and Hurtado have no relationships relevant to the contents of this article to disclose. This work was previously submitted as an abstract (podium presentation) at the 31st International Society of Pharmacoepidemiology (ISPE) Annual Conference; August 22-26, 2015; Boston, Massachusetts.

  12. Hombre, bienaventuranza y Dios en Suma Teológica l-ll, qq. 1-6.

    Directory of Open Access Journals (Sweden)

    Ariadne Pérez Treviño

    2013-11-01

    Full Text Available This article studies the Aquinas' proposal on Summa Theologica I-II, qq-1-6, where he studies how should the final end of the man be and concludes that it should be transcendental in a certain way, but immanent in another and that God is the immanent end; then, he studies the way in which man will get it and he finds out that it requires unity in three ways: unity between body and soul, intelligence and will, and finally, between the man, who is well disposed to contemplation and contemplation itself.

  13. A reproductive threat-based model of evolved sex differences in jealousy.

    Science.gov (United States)

    Sagarin, Brad J; Becker, D Vaughn; Guadagno, Rosanna E; Wilkinson, Wayne W; Nicastle, Lionel D

    2012-08-10

    Although heterosexual women and men consistently demonstrate sex differences in jealousy, these differences disappear among lesbians and gay men as well as among heterosexual women and men contemplating same-sex infidelities (infidelities in which the partner and rival are the same sex). Synthesizing these past findings, the present paper offers a reproductive threat-based model of evolved sex differences in jealousy that predicts that the sexes will differ only when the jealous perceivers' reproductive outcomes are differentially at risk. This model is supported by data from a web-based study in which lesbians, gay men, bisexual women and men, and heterosexual women and men responded to a hypothetical infidelity scenario with the sex of the rival randomly determined. After reading the scenario, participants indicated which type of infidelity (sexual versus emotional) would cause greater distress. Consistent with predictions, heterosexual women and men showed a sex difference when contemplating opposite-sex infidelities but not when contemplating same-sex infidelities, whereas lesbians and gay men showed no sex difference regardless of whether the infidelity was opposite-sex or same-sex.

  14. A Reproductive Threat-Based Model of Evolved Sex Differences in Jealousy

    Directory of Open Access Journals (Sweden)

    Brad J. Sagarin

    2012-07-01

    Full Text Available Although heterosexual women and men consistently demonstrate sex differences in jealousy, these differences disappear among lesbians and gay men as well as among heterosexual women and men contemplating same-sex infidelities (infidelities in which the partner and rival are the same sex. Synthesizing these past findings, the present paper offers a reproductive threat-based model of evolved sex differences in jealousy that predicts that the sexes will differ only when the jealous perceivers' reproductive outcomes are differentially at risk. This model is supported by data from a web-based study in which lesbians, gay men, bisexual women and men, and heterosexual women and men responded to a hypothetical infidelity scenario with the sex of the rival randomly determined. After reading the scenario, participants indicated which type of infidelity (sexual versus emotional would cause greater distress. Consistent with predictions, heterosexual women and men showed a sex difference when contemplating opposite-sex infidelities but not when contemplating same-sex infidelities, whereas lesbians and gay men showed no sex difference regardless of whether the infidelity was opposite-sex or same-sex.

  15. A case of spuriously high CK-MB: Contemplate beyond cardiac

    Directory of Open Access Journals (Sweden)

    Rishard Abdul

    2017-10-01

    Full Text Available Creatine kinase-MB (CK-MB is a widely tested enzyme in cardiac disease and thus has important clinical implications. We relate the scenario of a young patient presenting with chest pain whose CK-MB levels remained inordinately elevated despite a normal total CK level, resolution of symptoms and exclusion of coronary artery disease. Further analysis by electrophoresis revealed the presence of a rare molecular variant of creatine kinase: macro-CK type 1. While this may be a benign finding, there are sparse data demonstrating an association with non-cardiac pathologies such as malignancy, endocrinopathies, connective tissue and autoimmune diseases. Thus, after further exclusion of these associated conditions, the patient was reassured on the likely benign nature of macro-CK in this case.

  16. Contemplation on Reading and Meaning of a Verse of Shahnameh

    OpenAIRE

    f Vejdani

    2012-01-01

    This essay tries to explain in detail the reasons for the preference of one reading of the 6th verse of introduction of Shahnameh which is about "praise of wisdom" over other readings. In order to achieve this goal, first, expressions like imprudent (kamkherad), unwise, and wise are explained as they are necessary for explaining the expression "dark wisdom" second, the essay explains the concepts "dark wisdom" and "enlightened soul", and makes it clear that if some other verses of Shahnameh t...

  17. 29 CFR 779.228 - Types of arrangements contemplated by exception.

    Science.gov (United States)

    2010-07-01

    ... Coverage Leased Departments, Franchise and Other Business Arrangements § 779.228 Types of arrangements... section 3(s) would not otherwise apply: (a) Any arrangement, whether by agreement, franchise or otherwise...

  18. [Contemplation on the application of big data in clinical medicine].

    Science.gov (United States)

    Lian, Lei

    2015-01-01

    Medicine is another area where big data is being used. The link between clinical treatment and outcome is the key step when applying big data in medicine. In the era of big data, it is critical to collect complete outcome data. Patient follow-up, comprehensive integration of data resources, quality control and standardized data management are the predominant approaches to avoid missing data and data island. Therefore, establishment of systemic patients follow-up protocol and prospective data management strategy are the important aspects of big data in medicine.

  19. Self-efficacy, pros, and cons as variables associated with adjacent stages of change for regular exercise in Japanese college students.

    Science.gov (United States)

    Horiuchi, Satoshi; Tsuda, Akira; Kobayashi, Hisanori; Fallon, Elizabeth A; Sakano, Yuji

    2017-07-01

    This study examined self-efficacy (confidence to exercise), pros (exercise's advantages), and cons (exercise's disadvantages) as variables associated across the transtheoretical model's six stages of change in 403 Japanese college students. A series of logistic regression analyses were conducted. Results showed that higher pros and lower cons were associated with being in contemplation compared to precontemplation. Lower cons were associated with being in preparation compared to contemplation. Higher self-efficacy was associated with being in action compared to preparation as well as being in maintenance compared to action. Lower cons were associated with being in termination compared to maintenance.

  20. Les nourritures substantielles du corps et de l’Esprit

    Directory of Open Access Journals (Sweden)

    Roselyne Roth-Haillote

    2006-05-01

    Full Text Available Cet article examine, dans un monastère de contemplatives1, de quelles façons s’alternent ou se superposent les nourritures du corps et de l’esprit, fournissant aux épouses du Seigneur une préservation physique et spirituelle pour mieux atteindre la finalité de leur vocation.Taking place in a monastery of contemplative nuns2, this article looks at the various ways of feeding the mind and the body, thus giving the Lord’s wives both a physical and spiritual strengh to reach the highlight of their vocation.

  1. Protection motivation theory and stages of change in sun protective behavior.

    Science.gov (United States)

    Prentice-Dunn, Steven; McMath, Ben F; Cramer, Robert J

    2009-03-01

    This study examined the usefulness of the stage of change model and protection motivation theory (PMT) in creating brief persuasive appeals to promote healthy sun-behavior. College women (N = 254) read one of four essays that manipulated the level of threat and coping appraisal. The transition from the precontemplation to contemplation stage was promoted by threat appraisal information, but transition from contemplation to the preparation stage occurred only when individuals were provided with both high threat and high coping information. Thus, brief communications based on PMT may create attitudes leading to behavior change when later, more intensive, interventions are introduced.

  2. Silent transmissions and noisy interventions

    DEFF Research Database (Denmark)

    Bjørnsten, Thomas

    2011-01-01

    When contemplating modern art and aesthetics through models of in/compatibility, the motifs of noise and silence seem to emerge by default. One way to address the ”in/compatibility” theme, would be, then, to trace the roots of these motifs from both a historical and aesthetic-theoretical perspect......When contemplating modern art and aesthetics through models of in/compatibility, the motifs of noise and silence seem to emerge by default. One way to address the ”in/compatibility” theme, would be, then, to trace the roots of these motifs from both a historical and aesthetic...

  3. Common Sense Approach to the Restoration of Sacred Art

    Directory of Open Access Journals (Sweden)

    Alphonso Lopez Pinto

    2014-12-01

    Full Text Available In this paper, Sacred Art is examined as an imitation of historia. Historia interprets historical human events as empirical, material and real while seeking to understand their moral and spiritual significance. It is from historia that sacred art can be understood, where Christ and the saints are portrayed in the integrity of their human natures united to symbols representing Divinity or grace in order to present a visual/contemplative narrative. Mortimer Adler rightly sees that the vision of the beautiful is inherently contemplative, thus sacred iconography provides a language that can form the common sense of men and women.

  4. Is exercise important in chronic obstructive pulmonary disease?

    Science.gov (United States)

    Make, Barry; Casaburi, Richard

    2007-09-01

    Chronic obstructive pulmonary disease impairs the ability of patients to perform maximal physical exercise, particularly in patients with severe lung disease. However, differing perceptions of the meaning and importance of exercise to patients and caregivers is likely to impair patient-physician communication about current medical status and outcomes of therapeutic interventions. Other outcomes of importance to patients including actual performance of functional activity during daily life and health-related quality of life may also be affected by impaired exercise capacity. However, the relationships between exercise, activity, and quality of life are inconsistent. Thus, measurement of physiologic and patient-centered outcomes may provide the best approach to assessing responses to therapeutic interventions. These concepts were explored in a conference sponsored by Boehringer Ingelheim Pharmaceuticals, Inc. and Pfizer Inc and reviewed in the articles generated from the symposium in this issue of COPD.

  5. Application of transtheoretical model to assess the compliance of chronic periodontitis patients to periodontal therapy

    Directory of Open Access Journals (Sweden)

    Shilpa Emani

    2016-01-01

    Full Text Available Background: The present cross-sectional survey study was conducted to assess whether the transtheoretical model for oral hygiene behavior was interrelated in theoretically consistent directions in chronic periodontitis patients and its applicability to assess the compliance of the chronic periodontitis patients to the treatment suggested. Materials and Methods: A total of 150 chronic periodontitis patients were selected for the proposed study. The selected patients were given four questionnaires that were constructed based on transtheoretical model (TTM, and the patients were divided subsequently into five different groups (precontemplation, contemplation, preparation, action, and maintenance groups based on their answers to the questionnaires. Then, each patient was given four appointments for their periodontal treatment spaced with a time gap of 10 days. The patients visit for each appointments scheduled to them was documented. The results obtained were assessed using TTM. Results: Higher mean pro scores of decisional balance, self-efficacy, and process of change scores was recorded in maintenance group followed by action group, preparation group, contemplation group, and precontemplation group, respectively, whereas higher mean cons score was recorded in precontemplation group followed by contemplation group, preparation group, action group, and maintenance group, respectively. The difference scores of TTM constructs were statistically highly significant between all the five groups. Furthermore, the number of appointment attended in were significantly more than maintenance group followed by action group, preparation group, contemplation group, and precontemplation group. Conclusion: Within the limitations of this study, it can be concluded that transtheoretical model can be successfully applied to chronic periodontitis patients to assess their compliance to the suggested periodontal treatment.

  6. Prevalence and factors associated with stages of behavior change for physical activity in adolescents: a systematic review.

    Science.gov (United States)

    Nunes, Heloyse Elaine Gimenes; Silva, Diego Augusto Santos; Gonçalves, Eliane Cristina de Andrade

    2017-06-01

    To analyze prevalence and factors associated with stages of behavior change for physical activity in adolescents. A search was performed in SciELO, PubMed, PsycINFO, SPORTDiscus and LILACS. The search terms were "behavior change" OR "stages of change" OR "stages of readiness" OR "readiness to change" OR "transtheoretical model" OR "process to change" OR "decisional balance", and "motor activity" OR "physical activity" OR "physical exercise" and "adolescent" OR "students". After the eligibility criteria, 18 articles were selected. The highest prevalence of adolescents in the precontemplation, contemplation, and preparation stages was found in the Germany, South Korea, and Iran while there were more adolescents in the action and maintenance in South Korea and Brazil. The evidence of association indicated that females are more likely to be in precontemplation, contemplation and preparation. The evidence was inconclusive for age (in relation to the precontemplation, contemplation, action and maintenance stages), economic status (all stages), shift of study (when stratified by gender) and body composition (all stages). No association was found with parental level of education. The findings can help to guide interventions and further research on the topic of behavior changes for physical activity in adolescents.

  7. Associations between Poor Sleep Quality and Stages of Change of Multiple Health Behaviors among Participants of Employee Wellness Program.

    Science.gov (United States)

    Hui, Siu-Kuen Azor; Grandner, Michael A

    2015-01-01

    Using the Transtheoretical Model of behavioral change, this study evaluates the relationship between sleep quality and the motivation and maintenance processes of healthy behavior change. The current study is an analysis of data collected in 2008 from an online health risk assessment (HRA) survey completed by participants of the Kansas State employee wellness program (N=13,322). Using multinomial logistic regression, associations between self-reported sleep quality and stages of change (i.e. precontemplation, contemplation, preparation, action, maintenance) in five health behaviors (stress management, weight management, physical activities, alcohol use, and smoking) were analyzed. Adjusted for covariates, poor sleep quality was associated with an increased likelihood of contemplation, preparation, and in some cases action stage when engaging in the health behavior change process, but generally a lower likelihood of maintenance of the healthy behavior. The present study demonstrated that poor sleep quality was associated with an elevated likelihood of contemplating or initiating behavior change, but a decreased likelihood of maintaining healthy behavior change. It is important to include sleep improvement as one of the lifestyle management interventions offered in EWP to comprehensively reduce health risks and promote the health of a large employee population.

  8. Validating Stages of Change for Obesogenic Behaviors Across Filipino and Other Asian-American and Pacific Islander Adolescents.

    Science.gov (United States)

    Fleary, Sasha A; Tagorda, M; Kim, S; Rathke, M; Nigg, C R

    2018-06-01

    Filipino adolescents are underrepresented in obesity research, although Filipinos are the second largest Asian-American and Pacific Islander (AAPI) subpopulation in the USA. An understanding of how well the theories of behavior change apply to Filipino and other AAPI adolescents is critical to addressing obesogenic behaviors in these groups. This study aimed to validate the transtheoretical model of behavior change (TTM) for physical activity (PA) and fruit and vegetable intake (FV) among a majority Filipino adolescent population. Adolescents in grades 9-11 (N = 159, 82.4% female) completed measures of PA and FV behaviors and PA and FV stages of change. One-way ANOVAs and Tukey's HSD post hoc tests were computed to assess the validity of the PA and FV stages of change with the respective behaviors. There was a significant effect for fruit (action > contemplation, preparation) and vegetable (maintenance, action > contemplation) intakes across the FV stages of change. There was a significant effect of strenuous PA (precontemplation/contemplation, preparation Filipino and other AAPI adolescents. This validation, in turn, extends the generalizability of the stages of change construct to include this ethnic group and replicates other adolescent studies.

  9. Perspectives on Psychological Science: Right Way/Wrong Way Symposium.

    Science.gov (United States)

    Gunnar, Megan R

    2017-07-01

    In unpredictable times, it is perhaps even more important to contemplate the direction different fields of science are headed. In this article, I contemplate two directions of psychological science: the increasing integration of the study of psychology with other sciences and the concern of many sciences, including ours, with improving the reproducibility of our findings. Both of these are argued to be "right ways," but these directions also have challenges that, unless carefully addressed, could detract from our ability to move the science of psychology forward. I detail these challenges along with a consideration of how to chart our science through the unpredictable waters we face at this point in history.

  10. Efficacy and safety of eco-friendly inhalers: focus on combination ipratropium bromide and albuterol in chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Panos RJ

    2013-04-01

    Full Text Available Ralph J Panos1,2 1Pulmonary, Critical Care, and Sleep Medicine Division, Cincinnati Veterans Affairs Medical Center, 2Pulmonary, Critical Care, and Sleep Medicine Division, University of Cincinnati College of Medicine, Cincinnati, OH, USA Background: Chronic obstructive pulmonary disease (COPD is a major cause of morbidity and mortality and its treatment is critical to improve quality of life, reduce symptoms, and diminish the frequency of COPD exacerbations. Due to the harmful environmental effects of pressurized metered-dose inhalers (pMDIs containing chlorofluorocarbons (CFCs, newer systems for delivering respiratory medications have been developed. Methods: A search of the literature in the PubMed database was undertaken using the keywords “COPD,” “albuterol,” “ipratropium bromide,” and “Respimat® Soft Mist Inhaler™”; pertinent references within the identified citations were included. The environmental effect of CFC-pMDIs, the invention of the Respimat® Soft Mist Inhaler™ (SMI (Boehringer Ingelheim, Ingelheim, Germany, and its use to deliver the combination of albuterol and ipratropium bromide for the treatment of COPD were reviewed. Results: The adverse environmental effects of CFC-pMDIs stimulated the invention of novel delivery systems including the Respimat SMI. This review presents its development, internal mechanism, and use to deliver the combination of albuterol and ipratropium bromide. Conclusion: CFC-pMDIs contributed to the depletion of the ozone layer and the surge in disorders caused by harmful ultraviolet B radiation. The banning of CFCs spurred the development of novel delivery systems for respiratory medications. The Respimat SMI is an innovative device that produces a vapor of inhalable droplets with reduced velocity and prolonged aerosol duration that enhance deposition within the lower airway and is associated with improved patient satisfaction. Clinical trials have demonstrated that the Respimat SMI

  11. In vitro dose comparison of Respimat® inhaler with dry powder inhalers for COPD maintenance therapy

    Directory of Open Access Journals (Sweden)

    Ciciliani A

    2017-05-01

    Full Text Available Anna-Maria Ciciliani,1,2 Peter Langguth,1 Herbert Wachtel2 1Institute of Pharmacy and Biochemistry, Faculty 09 (Chemistry, Pharmaceutics and Geosciences, Johannes Gutenberg University, Mainz, 2Analytical Development Department, Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany Background: Combining in vitro mouth–throat deposition measurements, cascade impactor data and computational fluid dynamics (CFD simulations, four different inhalers were compared which are indicated for chronic obstructive pulmonary disease (COPD treatment.Methods: The Respimat inhaler, the Breezhaler, the Genuair, and the Ellipta were coupled to the idealized Alberta throat model. The modeled dose to the lung (mDTL was collected downstream of the Alberta throat model using either a filter or a next generation impactor (NGI. Idealized breathing patterns from COPD patient groups – moderate and very severe COPD – were applied. Theoretical lung deposition patterns were assessed by an individual path model.Results and conclusion: For the Respimat the mDTL was found to be 59% (SD 5% for the moderate COPD breathing pattern and 67% (SD 5% for very severe COPD breathing pattern. The percentages refer to nominal dose (ND in vitro. This is in the range of 44%–63% in vivo in COPD patients who display large individual variability. Breezhaler showed a mDTL of 43% (SD 2% for moderate disease simulation and 51% (SD 2% for very severe simulation. The corresponding results for Genuair are mDTL of 32% (SD 2% for moderate and 42% (SD 1% for very severe disease. Ellipta vilanterol particles showed a mDTL of 49% (SD 3% for moderate and 55% (SD 2% for very severe disease simulation, and Ellipta fluticasone particles showed a mDTL of 33% (SD 3% and 41% (SD 2%, respectively for the two breathing patterns. Based on the throat output and average flows of the different inhalers, CFD simulations were performed. Laminar and turbulent steady flow calculations indicated that

  12. [Screening for colorectal cancer: a cost benefit analysis on a health prevention programme at the Boehringer Ingelheim Company].

    Science.gov (United States)

    Schneider, M; Häck, H-J

    2011-05-01

    In Germany, approximately 70.000 people are diagnosed with colorectal cancer every year. With early diagnosis the recovery rates are over 90 % and early intervention can significantly reduce the costs of medical treatment as well as the economic losses from worker productivity. We here present the organisational procedure for bowel cancer screening and have weighed the costs against benefits to employees, the company and the healthcare system. The screening costs are compared with economic benefits. The target group for the study consisted of all 11.536 employees at the company's site in Germany. Volunteers were given a standardized questionnaire about the risk factors for colorectal cancers and an immunological fecal occult blood test (IFOBT). If risk factors for development of colorectal cancer were present or if the test result was positive, a colonoscopy was recommended in accordance with DGVS guidelines (German Society of Digestive and Metabolic diseases). A total of 4.287 employees (37.2 %) indicated an interest in undergoing screening; at the end of the period 3.958 complete datasets (2.296 men and 1.662 women, mean age 51.2 years) were available for evaluation. A colonoscopy was performed on 114 persons. Six cases of overt cancer were detected with three in the 36 - 50 age group and three in the 51 - 65 age group. Five of the six cases were stage T1 or T2. Adenomatous polyps were found and removed in 29 persons. The calculated cost benefit ratio was 1:2 for the company and 1:35 for the public health system. Using the example of colorectal screening, this study represents a cost benefit analysis of this preventative health measure in a company environment. The results show that even while taking into account the financial and personal commitment required, the cost benefit ratio is positive both for the company and for the healthcare system. © Georg Thieme Verlag KG Stuttgart · New York.

  13. Contemplating case mix: A primer on case mix classification and management.

    Science.gov (United States)

    Costa, Andrew P; Poss, Jeffery W; McKillop, Ian

    2015-01-01

    Case mix classifications are the frameworks that underlie many healthcare funding schemes, including the so-called activity-based funding. Now more than ever, Canadian healthcare administrators are evaluating case mix-based funding and deciphering how they will influence their organization. Case mix is a topic fraught with technical jargon and largely relegated to government agencies or private industries. This article provides an abridged review of case mix classification as well as its implications for management in healthcare. © 2015 The Canadian College of Health Leaders.

  14. Fatal Amusements: Contemplating the Tempest of Contemporary Media and American Culture

    Science.gov (United States)

    Strate, Lance

    2016-01-01

    Our use of the electronic media to conduct serious discourse raises the question of whether "we are amusing ourselves to death," as Neil Postman argued. The approach known as "media ecology," the study of media as environments, which emphasizes the need to understand context and find balance, provides a basis for the analysis…

  15. Mindfulness and Compassion Training in Adolescence: A Developmental Contemplative Science Perspective

    Science.gov (United States)

    Roeser, Robert W.; Pinela, Cristi

    2014-01-01

    Adolescence is a developmental period of risk, as well as a window of opportunity for cultivating positive development and thriving. It is characterized by simultaneous changes in the brain, body, mind, and social domains that offer a platform for building new skills and habits. This chapter discusses the role that secular forms of mindfulness and…

  16. Environmental Education as a Lived-Body Practice? A Contemplative Pedagogy Perspective

    Science.gov (United States)

    Pulkki, Jani; Dahlin, Bo; Varri, Veli-Matti

    2017-01-01

    Environmental education usually appeals to the students' knowledge and rational understanding. Even though this is needed, there is a neglected aspect of learning ecologically fruitful action; that of the lived-body. This paper introduces the lived-body as an important site for learning ecological action. An argument is made for the need of a…

  17. Flexible High Energy-Conversion Sensing Materials for Structural Health Monitoring, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The applicant is developing flexible highly-efficient piezoelectric materials for use in structural health monitoring (SHM) as contemplated in the solicitation...

  18. 78 FR 73553 - Prospective Grant of Exclusive License: Development of Cripto-1 Point of Care (POC) Tests and...

    Science.gov (United States)

    2013-12-06

    ... contemplated exclusive license should be directed to: Eggerton Campbell, Ph.D. Licensing and Patenting Manager... colon, pancreas, stomach, gallbladder, breast, lung, endometrium and cervix. Current methodologies of...

  19. 48 CFR 52.236-4 - Physical Data.

    Science.gov (United States)

    2010-10-01

    ..., such as surveys, auger borings, core borings, test pits, probings, test tunnels]. (b) Weather... fixed-price construction contract is contemplated and physical data (e.g., test borings, hydrographic...

  20. 48 CFR 852.228-71 - Indemnification and insurance.

    Science.gov (United States)

    2010-10-01

    ... negligence or alleged negligence of the Government, its officers, agents, servants, and employees, shall not... liability coverage will conform to applicable State law requirements for the service contemplated, whereas...

  1. Marketing a Menu.

    Science.gov (United States)

    1987-10-31

    Patients contemplating the relative nutritional values of mixed macedoine of vegetables and pea puree will soon be finding their hospital menu cards enlivened by supermarkets, travel services and other adverts.

  2. Everything, just to look at you

    Directory of Open Access Journals (Sweden)

    Mariela Garibay Ibargüen

    2011-05-01

    Full Text Available Working in stone and particularly with Calatorao marble is always a personal challenge given its quality and hardness. Without a doubt to be able to work consistently in sculpture, in fine arts in general is a permanent challenge between continuing to work creatively or to withdraw given the number of daily adversities that confront those within the profession. So why continue if there are so many difficulties? Why sculpt new works? I have often asked myself that and one of the answers that occurs to me is that when I see my work, or that of my colleagues, one often contributes to art for the “mere pleasure of contemplating it” All for the sake of contemplation.

  3. Re an Adoption Application (Surrogacy), 11 March 1987.

    Science.gov (United States)

    1987-01-01

    The Court was asked to make an adoption order in favor of a couple who had paid another woman to bear a child for them using the husband's sperm. The Court made the order, noting that the Surrogacy Arrangements Act 1985, which bans commercial surrogacy agencies, negotiations, and advertisements had not been enacted at the time of this arrangement. It also held that the arrangement did not violate the Adoption Act 1958, which prohibits payments or rewards for or in consideration of adoption, because the payment to the surrogate was not made in contemplation of adoption. Moreover, it concluded that even if the payment had been made in contemplation of adoption, the Adoption Act gave the Court the power to authorize the payment retrospectively. full text

  4. Looking up to the sky! An exploration of new graduate nurses' perceptions of remote area nursing.

    Science.gov (United States)

    Hart, Bethne; Black, James; Hillery, Jayde; Smith, Sophie

    2014-01-01

    Remote area nursing is characterised by two known realities: health inequalities and nursing challenges. The health inequalities are complex consequences of social determinants and health care access. Remote area nurses must negotiate these realities that powerfully interact. Yet we, as new graduate nurses, contemplate a remote area nursing career pathway with additional points of view, including a strong attraction to the long-lasting image of the 'Flying Nurse' within aero medical remote health services. This image holds for us the possibilities of excitement, drama, vital service, and intensive care. This paper explores the realities of this career attraction, and consequently explores the aspirations of contemplative new graduate nurses, as they assimilate their knowledge of remote area nursing with their plans for their future transitions into nursing practice.

  5. Precautions to be taken by radiologists and radiographers when prescribing hyoscine-N-butylbromide

    Energy Technology Data Exchange (ETDEWEB)

    Dyde, R. [Department of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds (United Kingdom); Chapman, A.H. [Department of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds (United Kingdom)], E-mail: tony_chapman@ntlworld.com; Gale, R. [Department of Opthalmology, University of Leeds, Leeds (United Kingdom); Mackintosh, A. [Department of Cardiology, Leeds Teaching Hospitals NHS Trust, Leeds (United Kingdom); Tolan, D.J.M. [Department of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds (United Kingdom)

    2008-07-15

    Hyoscine-N-butylbromide (Buscopan, Boehringer Ingelheim) is a widely used antispasmodic in radiological practice. There seems to be no consensus as to best practice within radiology regarding the precautions that need to be taken when prescribing Buscopan. We have performed a thorough review of the available literature and make the following recommendations to those administering Buscopan: (1) enquire whether there is an allergic history; (2) ensure patient literature warns that 'in the rare event that following the examination you develop painful, blurred vision in one or both eyes, you must attend hospital immediately for assessment'; (3) warn patients to expect blurred vision and not to drive until this has worn off; (4) remind clinicians that special consideration needs to be given as to the method of investigating patients with cardiac instability, such as those recently admitted with acute coronary syndrome, recurrent cardiac pain at rest, uncontrolled left ventricular failure and recent ventricular arrhythmias.

  6. Precautions to be taken by radiologists and radiographers when prescribing hyoscine-N-butylbromide

    International Nuclear Information System (INIS)

    Dyde, R.; Chapman, A.H.; Gale, R.; Mackintosh, A.; Tolan, D.J.M.

    2008-01-01

    Hyoscine-N-butylbromide (Buscopan, Boehringer Ingelheim) is a widely used antispasmodic in radiological practice. There seems to be no consensus as to best practice within radiology regarding the precautions that need to be taken when prescribing Buscopan. We have performed a thorough review of the available literature and make the following recommendations to those administering Buscopan: (1) enquire whether there is an allergic history; (2) ensure patient literature warns that 'in the rare event that following the examination you develop painful, blurred vision in one or both eyes, you must attend hospital immediately for assessment'; (3) warn patients to expect blurred vision and not to drive until this has worn off; (4) remind clinicians that special consideration needs to be given as to the method of investigating patients with cardiac instability, such as those recently admitted with acute coronary syndrome, recurrent cardiac pain at rest, uncontrolled left ventricular failure and recent ventricular arrhythmias

  7. Donated chemical probes for open science.

    Science.gov (United States)

    Müller, Susanne; Ackloo, Suzanne; Arrowsmith, Cheryl H; Bauser, Marcus; Baryza, Jeremy L; Blagg, Julian; Böttcher, Jark; Bountra, Chas; Brown, Peter J; Bunnage, Mark E; Carter, Adrian J; Damerell, David; Dötsch, Volker; Drewry, David H; Edwards, Aled M; Edwards, James; Elkins, Jon M; Fischer, Christian; Frye, Stephen V; Gollner, Andreas; Grimshaw, Charles E; IJzerman, Adriaan; Hanke, Thomas; Hartung, Ingo V; Hitchcock, Steve; Howe, Trevor; Hughes, Terry V; Laufer, Stefan; Li, Volkhart Mj; Liras, Spiros; Marsden, Brian D; Matsui, Hisanori; Mathias, John; O'Hagan, Ronan C; Owen, Dafydd R; Pande, Vineet; Rauh, Daniel; Rosenberg, Saul H; Roth, Bryan L; Schneider, Natalie S; Scholten, Cora; Singh Saikatendu, Kumar; Simeonov, Anton; Takizawa, Masayuki; Tse, Chris; Thompson, Paul R; Treiber, Daniel K; Viana, Amélia Yi; Wells, Carrow I; Willson, Timothy M; Zuercher, William J; Knapp, Stefan; Mueller-Fahrnow, Anke

    2018-04-20

    Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose. Several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have therefore entered into a pre-competitive collaboration to make available a large number of innovative high-quality probes, including all probe-associated data, control compounds and recommendations on use (https://openscienceprobes.sgc-frankfurt.de">https://openscienceprobes.sgc-frankfurt.dehttps://openscienceprobes.sgc-frankfurt.de/">/). Here we describe the chemical tools and target-related knowledge that have been made available, and encourage others to join the project. © 2018, Müller et al.

  8. 32 CFR 719.112 - Authority to grant immunity from prosecution.

    Science.gov (United States)

    2010-07-01

    .... (7) If the witness refused to comply with the order, whether contempt proceedings were instituted, or are contemplated, and the result of the contempt proceeding, if concluded. A verbatim transcript of...

  9. 76 FR 65518 - Prospective Grant of Exclusive License: The Development of a Companion Diagnostic Kit for...

    Science.gov (United States)

    2011-10-21

    ... contemplated exclusive license should be directed to: Patrick P. McCue, Ph.D., Licensing and Patenting Manager... has been demonstrated for biliary tract, kidney, lung, and stomach cancers. The prospective exclusive...

  10. 19 CFR 111.59 - Preliminary proceedings.

    Science.gov (United States)

    2010-04-01

    ... submissions and demonstrations of the character contemplated by the cited statutory provisions; (6) Invites... into; (7) Advises the broker of his right to be represented by counsel; (8) Specifies the place where...

  11. The Determination of Physical Activity among Girl Adolescents based on Trans-theoretical model (TTM

    Directory of Open Access Journals (Sweden)

    Masoumeh Alidosti

    2017-07-01

    Full Text Available Background It has been proved that physical activity has positive effects for all people. However, low activity is common among adolescents especially girl teenagers. The present study aimed to determine the condition of physical activity among girl adolescents by use of the stages of change derived from Trantheoretical model (TTM. Materials and Methods: This descriptive- analytical investigation was done (in 2016 and 2017 school year in the first – round girl high school among 324 students studying in state schools of Shahrekord city (Western Iran. They were selected through clustering method. The data were collected by researcher-made questionnaires including demographic characteristics, knowledge construct and the stages of change (pre-contemplation, contemplation, preparation, action and maintenance. The collected data were analyzed by SPSS (version 18.0. Results The mean age of participants was 13.69+ 1.95 years old. The mean score of girls' knowledge about types of physical activity was 53.18± 21.82 (a total of 100 scores, which represents the average level of knowledge among them. The study of physical activity in students based on stages of change showed that 165 ones (43 %, 102 ones (26.6 % and only 22 ones (5.7 % of the studied students were in precontemplation, contemplation and maintenance stages, respectively. There was a significant relation between students' knowledge level and their mothers' age (P

  12. Download this PDF file

    African Journals Online (AJOL)

    ...

    and memories, in cognitive acts such as thinking, contemplation ... focus of supervision needs to be the nurse-patient interaction ... cess, decision-making and reasoning about issues. It ... anonymity, and protection from psychological harm.

  13. The Springs of Leadership

    Directory of Open Access Journals (Sweden)

    Nathan Harter

    2006-06-01

    Full Text Available Leadership denotes activity, if not strenuous activity. Yet in its own way contemplation is an activity—an activity arguably at the root of leadership, which this meditation seeks to justify.

  14. Pre-marital and Marital Counselling: Implications for the School Guidance Counsellor

    Science.gov (United States)

    Schlesinger, Benjamin

    1978-01-01

    One of the foremost tasks of young people contemplating marriage is the discovery of their basic selfhood and their continued growth as people; this is the first goal in pre-marital counseliling. (Author)

  15. Contrasting trends of smoking cessation status: insights from the stages of change theory using data from the global adult tobacco survey

    Directory of Open Access Journals (Sweden)

    Lazarous Mbulo

    2018-03-01

    Full Text Available Background Quitting tobacco use can reduce smokers' risks for disease and premature death. We used the trans-theoretical behavior change model to examine temporal differences in readiness to quit smoking among adults in five countries. Methods We analyzed two independent samples from the Global Adult Tobacco Survey, a standardized national adult household survey of persons aged ≥15 years, for five countries: Mexico (2009, 2015, Philippines (2010, 2016, Thailand (2009, 2011, Turkey (2008, 2012, and Vietnam (2010, 2016. Response rates ranged 82.5%-96.3% and sample sizes ranged 8,996-20,606. Current smokers were defined as adults who smoked tobacco on a daily or non-daily basis. Using responses to questions assessing intention to quit cigarette smoking, we categorized current smokers into the following stages of change: pre-contemplation, contemplation, and preparation. Relative change was compared using z-tests ( p < 0.05. Results No significant change in smoking prevalence between wave 1 and 2 occurred for Mexico (15.9% to 16.4%, Thailand (23.7% to 24.0%, or Vietnam (23.8% to 22.5%. In contrast, smoking prevalence declined for Philippines (28.2% to 22.7% and Turkey (31.2% to 27.1%. There was an increase in the proportion of smokers in the pre-contemplation stage in Thailand (76.1% to 85.4% and Vietnam (70.8% to 82.3%, while a decline occurred in Turkey (31.2% to 27.1%; no significant change occurred in Mexico or Philippines. The proportion of smokers in the contemplation stage declined in Thailand (17.6% to 12.0% and Vietnam (21.6% to 14.1%, but increased in Turkey (21.2% to 26.9%; no significant change occurred in Mexico or Philippines. The proportion in the preparation stage declined in Thailand (6.3% to 2.6% and Vietnam (7.6% to 3.6%; no significant changes occurred in, Mexico, Philippines, or Turkey. Conclusions Using the stages of change model, smokers' readiness to quit varies by country. Tailored interventions towards specific stages of

  16. 75 FR 47810 - Granting of Request for Early Termination of the Waiting Period Under the Premerger Notification...

    Science.gov (United States)

    2010-08-09

    ...-Scott Rodino Antitrust Improvements Act of 1976, requires persons contemplating certain mergers or... status Party name 30-JUN-10 20100840 G Li & Fung Limited. G Steven Kahn. G The Max Leather Group, Inc. G...

  17. LA DISTINCIÓN ARISTOTÉLICA SOBRE LOS MODOS DE VIDA

    Directory of Open Access Journals (Sweden)

    Viviana Suñol

    2013-12-01

    Full Text Available The Aristotelian praise of the contemplative life in Nicomachean Ethics X was very influential in the history of philosophy and its effects go much more beyond the limits of Hellenism and Late Antiquity. Although, it is in Politics VII 1-3 where Aristotle presents the more detailed consideration of the ways of life, in particular, the opposition between the political and philosophical life. The purpose of this work is to reconsider the praise of the contemplative life at the end of NE and to recover the political significance that the ethical preface that precedes the design of the ideal polis has in this discussion in order to show the correspondence that exists between the redefinition of praxis in Pol. VII 3 and the hierarchy of eudaimonia in NE X 7-8.

  18. Wise Ways of Seeing: Wisdom and Perspectives

    Directory of Open Access Journals (Sweden)

    Roger Walsh

    2015-03-01

    Full Text Available The capacity for perspective taking is thought to be linked to psychological development and to wisdom. This article draws from psychological, contemplative, cross-cultural, and philosophical disciplines to create an inventory of perspectival skills and their possible relationships to wisdom. The nature of perspectives is explored, as are the characteristics of healthy perspectives, and the factors—such as developmental stage, assumptions, and state of mind—that determine the number and kinds of available perspectives. The article then examines rare postconventional perspectival capacities such as the ability to integrate multiple perspectives, to adopt higher order metaperspectives, and to experience transperspectival “pure awareness.” Fifteen kinds of wise perspectives and perspectival skills are suggested. Finally, the article reviews psychological, relational, contemplative, philosophical, and educational methods thought to foster perspectival skills and wisdom.

  19. Junior high school students’ reflective thinking on fraction problem solving: In case of gender differences

    Science.gov (United States)

    Rasyid, M. A.; Budiarto, M. T.; Lukito, A.

    2018-01-01

    This study aims to describe reflective thinking of junior high school students on solving the fractions problem in terms of gender differences. This research is a qualitative approach involving one male student and one female student in seventh grade. The data were collected through the assignment of fractional problem solving and interview, then the data were triangulated and analyzed by three stages, namely data condensation, data display and conclusion. The results showed that the subjects of male and female were reacting, elaborating and contemplating at each stage of solving the fractions problem. But at the stage of devising the plan, the female subject was contemplating, relying more on their beliefs, did not consider their experience, in addition, the female subject didn’t use experience of the steps she planned to solve the problem of fractions.

  20. What is it like to meditate? Methods and issues for micro-phenomenological description of meditative experience

    DEFF Research Database (Denmark)

    Petitmengin, Claire; Beek, Martijn van; Bitbol, Michel

    2017-01-01

    associated with contemplative practice: what it is like to meditate – from moment to moment, at different stages of practice – remains almost invisible in contemporary contemplative science. Recently, "micro-phenomenological" interview methods have been developed to help us become aware of lived experience......In our society where interest in Buddhist meditation is expanding enormously, numerous scientific studies are now conducted on the neurophysiological effects of meditation practices and on the neural correlates of meditative states. However, very few studies have been conducted on the experience...... and describe it with rigor and precision. The present article presents the results of a pilot project aiming at applying these methods to the description of meditative experience. The first part of the article describes these methods and their adjustment for the investigation of meditative experience...

  1. The pregnancy journey for women with type 1 diabetes

    DEFF Research Database (Denmark)

    Edwards, Helen; Speight, Jane; Bridgman, Heather

    2016-01-01

    The purpose of this study is to describe and develop a model of the pregnancy journey for women with type 1 diabetes. We undertook a thematic analysis of written interactions (n = 200; n = 2060 text excerpts) with an online counselling support service from 93 women with type 1 diabetes. Seven...... reassurance during Pregnancy; however, some women still worried, with peer support offering the most reassurance. In conclusion, women with type 1 diabetes potentially experience seven distinct phases of the pregnancy journey, with eight themes varying in significance across phases. Contemplation begins well...... possible discrete phases in the pregnancy journey were revealed: Contemplation, Pregnancy planning, Conception, Pregnancy, Delivery/birth, and Motherhood or Pregnancy loss. Eight common themes were identified, varying in importance across phases. Diabetes-specific distress was most evident during...

  2. SOSPES: SPIRIVA® observational study measuring SGRQ score in routine medical practice in Central and Eastern Europe

    Directory of Open Access Journals (Sweden)

    Fležar M

    2013-10-01

    Full Text Available Matjaž Fležar,1 Karina Jahnz-Rózyk,2 Gloria Enache,3 Tatiana Martynenko,4 Peter Kristufek,5 Sanda Škrinjaric-Cincar,6 Pavla Kadlecová,7 Goran Martinovic81University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia; 2Military Institute of Medicine, Department of Immunology and Allergology, Warsaw, Poland; 3Saint John Clinical Emergency Hospital, Bucharest, Romania; 4Municipal Medical Institution City Hospital, Barnaul, Russian Federation; 5SACCME, Slovak Medical University, Bratislava, Slovakia; 6Clinical Hospital Center, Osijek, Croatia; 7ADDS Sro, Jana Uhra, Brno, Czech Republic; 8Boehringer Ingelheim RCV GmbH and Co KG, Ingelheim, Vienna, AustriaPurpose: The long-acting inhaled anticholinergic agent, tiotropium, is recommended as first-line maintenance therapy for moderate to very severe Chronic Obstructive Pulmonary Disease (COPD to improve symptoms, exercise tolerance, health status, and to reduce exacerbations. Few studies have evaluated the therapeutic efficacy of tiotropium in patients in routine clinical conditions. The current study was designed to investigate the therapeutic efficacy of tiotropium delivered via the HandiHaler® device on the health status of patients with COPD with Global initiative for chronic Obstructive Lung Disease (GOLD disease classification 2–4 in six central and eastern European countries in a real-life clinical setting.Methods: The study was an open-label, prospective, uncontrolled, and single-arm surveillance study with three clinic visits during a 6-month observation period (baseline, and months 3 and 6. Health status was measured using the disease-specific St George's Respiratory Questionnaire (SGRQ. The primary efficacy endpoint was the mean change from baseline in SGRQ total score at the end of the 6-month observational period.Results: Patients treated with tiotropium 18 µg once daily showed statistically significant and clinically meaningful reduction (improvement of 21

  3. Guideline-based survey of outpatient COPD management by pulmonary specialists in Germany

    Directory of Open Access Journals (Sweden)

    Buhl R

    2012-02-01

    Full Text Available Thomas Glaab1,2, Claus Vogelmeier3, Andreas Hellmann4, Roland Buhl11Department of Respiratory Diseases III, Medical Center of the Johannes Gutenberg-University, Mainz, 2Medical Affairs Germany, Respiratory Medicine, Boehringer Ingelheim Pharma GmbH and Co, KG, Ingelheim, 3Department of Respiratory Diseases, University Hospitals of Giessen and Marburg, Marburg, 4Federal Association of Pneumologists, Augsburg, GermanyBackground: Little is known about the role of guidelines for the practical management of chronic obstructive pulmonary disease (COPD by office-based pulmonary specialists. The aim of this study was to assess their outpatient management in relation to current guideline recommendations for COPD.Methods: A nationwide prospective cross-sectional COPD questionnaire survey in the form of a multiple-choice questionnaire was sent to 1000 office-based respiratory specialists in Germany. The product-neutral questions focused on routine COPD management and were based on current national and international COPD guideline recommendations being consistent in severity classification and treatment recommendations.Results: A total of 590 pulmonary specialists (59% participated in the survey. Body plethysmography was considered the standard for diagnosis (65.9%, followed by spirometry (32%. Most respondents were able to cite the correct spirometric criteria for classifying moderate (87% to very severe COPD (77%. A quarter of the respondents equated the World Health Organization (WHO definition of chronic bronchitis with COPD. Notably, most participants preferred the updated national COPD guidelines (51.4% to the Global Initiative for Chronic Obstructive Lung Disease (GOLD guidelines (40.2%. Improvement of functional exercise capacity and quality of life were considered the two most relevant treatment goals; whereas impact on mortality was secondary. Treatment of COPD largely complied with the guidelines. However, a significant percentage of the

  4. Lung function efficacy and symptomatic benefit of olodaterol once daily delivered via Respimat® versus placebo and formoterol twice daily in patients with GOLD 2–4 COPD: results from two replicate 48-week studies

    Directory of Open Access Journals (Sweden)

    Koch A

    2014-07-01

    Full Text Available Andrea Koch,1 Emilio Pizzichini,2 Alan Hamilton,3 Lorna Hart,3 Lawrence Korducki,4 Maria Cristina De Salvo,5 Pierluigi Paggiaro6 1Medical Clinic III for Pneumology, Allergology, Sleep and Respiratory Medicine, University Hospital Bochum-Bergmannsheil, Bochum, Germany; 2NUPAIVA (Asthma Research Center, Universidade Federal de Santa Catarina, Santa Catarina, Brazil; 3Boehringer Ingelheim, Burlington, Ontario, Canada; 4Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA; 5Centro Médico Dra. De Salvo, Fundación Respirar, Buenos Aires, Argentina; 6Cardio-Thoracic and Vascular Department, University of Pisa, Pisa, Italy Abstract: Two replicate, multicenter, randomized, double-blind, placebo-controlled, parallel-group, Phase III studies investigated the long-term efficacy and safety of once-daily olodaterol via Respimat® versus placebo and formoterol over 48 weeks in patients with moderate to very severe chronic obstructive pulmonary disease receiving usual-care background therapy. Patients received once-daily olodaterol 5 or 10 µg, twice-daily formoterol 12 µg, or placebo. Co-primary end points were forced expiratory volume in 1 second (FEV1 area under the curve from 0–3 hours response, FEV1 trough response, and Mahler transition dyspnea index total score after 24 weeks; secondary end points included St George's Respiratory Questionnaire. Overall, 904 (Study 1222.13 and 934 (Study 1222.14 patients received treatment. Olodaterol significantly improved FEV1 area under the curve from 0–3 hours versus placebo in both studies (with olodaterol 5 µg, 0.151 L and 0.129 L; with olodaterol 10 µg, 0.165 L and 0.154 L; for all comparisons P<0.0001 and FEV1 trough responses versus placebo (0.053–0.085 L; P<0.01, as did formoterol. Primary analysis revealed no significant difference in transition dyspnea index focal score for any active treatment versus placebo. Post hoc analysis using pattern mixture modeling (accounting for

  5. A critique of mission education in South Africa according to Bosch's ...

    African Journals Online (AJOL)

    Erna Kinsey

    to the granting of financial aid in 1841 to mission education: •. The prevalent colonial ..... Handbook on Race relations in ... Eggert NH 1998. Contemplative leadership for entrepreneurial ... Cape Town: Oxford University Press. Horrel M 1963.

  6. 44 CFR 1.4 - Policy and procedures.

    Science.gov (United States)

    2010-10-01

    ... economy, and other regulatory actions contemplated for the future. (b) It is the policy of FEMA to provide... include a statement with respect to the impact of the proposed rule on small entities; holding open...

  7. 78 FR 50425 - Prospective Grant of Exclusive License: Development of Brachyury Tumor Associated Antigens as...

    Science.gov (United States)

    2013-08-19

    ... relating to the contemplated exclusive license should be directed to: Sabarni K. Chatterjee, Ph.D., M.B.A... target for human T-cell mediated cancer immunotherapy, such as for tumors of the lung, intestine, stomach...

  8. Inverter-based successive approximation capacitance-to-digital converter

    KAUST Repository

    Omran, Hesham; Alhoshany, Abdulaziz; Salama, Khaled N.

    2017-01-01

    offset voltage will result in signal-dependent and parasitic-dependent conversion errors, which necessitates an op-amp-based implementation. The inverter-based SAR CDC contemplated herein provides robust, energy-efficient, and fast operation. The inverter

  9. 77 FR 13322 - Termination of Dormant Proceedings

    Science.gov (United States)

    2012-03-06

    ... required or contemplated, as well as those in which no pleadings or other documents have been filed for... is procedural in nature or otherwise does not address the merits of the proceeding. Prior to the...

  10. 76 FR 35892 - Termination of Dormant Proceedings

    Science.gov (United States)

    2011-06-20

    ... required or contemplated, as well as those in which no pleadings or other documents have been filed for... is procedural in nature or otherwise does not address the merits of the proceeding. Prior to the...

  11. A contemplation on the secondary origin of green algal and plant plastids

    Directory of Open Access Journals (Sweden)

    Eunsoo Kim

    2014-12-01

    Full Text Available A single origin of plastids and the monophyly of three “primary” plastid-containing groups – the Chloroplastida (or Viridiplantae; green algae+land plants, Rhodophyta, and Glaucophyta – are widely accepted, mainstream hypotheses that form the basis for many comparative evolutionary studies. This “Archaeplastida” hypothesis, however, thus far has not been unambiguously confirmed by phylogenetic studies based on nucleocytoplasmic markers. In view of this as well as other lines of evidence, we suggest the testing of an alternate hypothesis that plastids of the Chloroplastida are of secondary origin. The new hypothesis is in agreement with, or perhaps better explains, existing data, including both the plastidal and nucleocytoplasmic characteristics of the Chloroplastida in comparison to those of other groups.

  12. Identity, transcendence and the true self: Insights from psychology and contemplative spirituality

    Directory of Open Access Journals (Sweden)

    Carter Haynes

    2016-11-01

    Full Text Available This article investigates the intersection of psychology and spirituality as seen through the works of Thomas Merton, Carl Jung, Fritz Kunkel and Viktor Frankl. The themes of spirituality contextualised in human identity, psychological and spiritual transcendence, and the true self versus false self metaphor are traced through the works of all four thinkers. Epistemological flexibility and holistic thinking and being are suggested as methods for transforming interdisciplinary practitioners, such as pastoral counsellors, spiritual directors and spiritually oriented psychotherapists, in order that they can offer care in a less bifurcated and more integrated way. Practical applications, including a vignette and specific recommendations for broadening and deepening personal and professional integrative practice, are offered.

  13. Occupational exposure at a contemplated Belarussian power plant fired with contaminated biomass

    DEFF Research Database (Denmark)

    Andersson, Kasper Grann; Fogh, C.L.; Roed, Jørn

    1999-01-01

    To meet the current demand in Belarus for remediation of the vast forest areas that were contaminated by the Chernobyl accident and at the same time establish a much needed energy production, applying contaminated forest biomass as fuel in special power plants is being considered. This paper......-called 'big bags' filled with fly ash waste. Inhalation doses were estimated to be low. External doses received while working at the power plant do not appear to be highly significant compared with the doses from environmental contamination in the area where the power plant is expected to be constructed....

  14. Power in health care organizations: contemplations from the first-line management perspective.

    Science.gov (United States)

    Isosaari, Ulla

    2011-01-01

    The aim of this paper is to examine health care organizations' power structures from the first-line management perspective. What liable power structures derive from the theoretical bases of bureaucratic, professional and result based organizations, and what power type do health care organizations represent, according to the empirical data? The paper seeks to perform an analysis using Mintzberg's power configurations of instrument, closed system, meritocracy and political arena. The empirical study was executed at the end of 2005 through a survey in ten Finnish hospital districts in both specialized and primary care. Respondents were all first-line managers in the area and a sample of staff members from internal disease, surgical and psychiatric units, as well as out-patient and primary care units. The number of respondents was 1,197 and the response percentage was 38. The data were analyzed statistically. As a result, it can be seen that a certain kind of organization structure supports the generation of a certain power type. A bureaucratic organization generates an instrument or closed system organization, a professional organization generates meritocracy and also political arena, and a result-based organization has a connection to political arena and meritocracy. First line managers regarded health care organizations as instruments when staff regarded them mainly as meritocracies having features of political arena. Managers felt their position to be limited by rules, whereas staff members regarded their position as having lots of space and influence potential. If the organizations seek innovative and active managers at the unit level, they should change the organizational structure and redistribute the work so that there could be more space for meaningful management. This research adds to the literature and gives helpful suggestions that will be of interest to those in the position of first-line management in health care.

  15. Logistics in 2025: Consider It DoneZ

    National Research Council Canada - National Science Library

    Edgell, Jaydee

    1996-01-01

    Accessibility replaces anxiety in 2025 logistics. Confident that logistics systems will generate what they need when they need it, commanders of aerospace forces in the year 2025 contemplate strategy and devote their energy to the battle...

  16. Viewpoint

    African Journals Online (AJOL)

    We contemplated the effect this had on our intuitive assessment of our accommodation and surrounding ... pleasures of playing video games or listening to fugues derive from instinctive processes that were in ... to our teenagers today? Note.

  17. 29 CFR 452.38 - Meeting attendance requirements.

    Science.gov (United States)

    2010-07-01

    ... prevented by union activities or working hours, with the result that 96.5 percent of the members were... the type of flexible result that Congress contemplated when it used the word “reasonable.” The Court...

  18. HCVerso1 and 2: faldaprevir with deleobuvir (BI 207127 and ribavirin for treatment-naïve patients with chronic hepatitis C virus genotype-1b infection

    Directory of Open Access Journals (Sweden)

    Sarrazin C

    2016-11-01

    Full Text Available Christoph Sarrazin,1 Francesco Castelli,2 Pietro Andreone,3 Maria Buti,4 Massimo Colombo,5 Stanislas Pol,6 Filipe Calinas,7 Massimo Puoti,8 Antonio Olveira,9 Mitchell Shiffman,10 Jerry O Stern,11 George Kukolj,12 Michael Roehrle,13 Stella Aslanyan,11 Qiqi Deng,11 Richard Vinisko,11 Federico J Mensa,11 David R Nelson,14 on behalf of the HCVerso1 and 2 study groups 1Department of Internal Medicine 1, JW Goethe University Hospital, Frankfurt, Germany; 2Department of Infectious and Tropical Diseases, University of Brescia, Brescia, 3Department of Medical and Surgical Sciences, Università di Bologna and Azienda Ospedaliero-Universitaria, Policlinico Sant‘Orsola-Malpighi, Bologna, Italy; 4Department of Internal Medicine, Hospital Universitari Vall d’Hebron and CIBERehd del Instituto Carlos III, Barcelona, Spain; 5Division of Gastroenterology and Hepatology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy; 6University Paris Descartes, Department of Hepatology, Hospital Cochin, APHP and INSERM UMS-20, Institut Pasteur, Paris, France; 7Department of Gastroenterology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal; 8Department of Infectious Diseases, AO Ospedale Niguarda Cà Granda, Milan, Italy; 9Liver Unit, Hospital Universitario La Paz, CIBERehd, Madrid, Spain; 10Liver Institute of Virginia, Bon Secours Health System, Richmond, VA, USA; 11Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA; 12Boehringer Ingelheim Ltd/Ltée, Burlington, ON, Canada; 13Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany; 14Clinical and Translational Science Institute, University of Florida, Gainesville, FL, USA Abstract: The interferon-free combination of once-daily faldaprevir 120 mg, twice-daily deleobuvir 600 mg, and weight-based ribavirin was evaluated in two Phase III studies (HCVerso1, HCVerso2 in hepatitis C virus genotype-1b-infected, treatment-naïve patients, including

  19. Spiritually journeying through illness: default or devoted God?

    Science.gov (United States)

    Wilder, Mary

    2010-01-01

    Nurses have the opportunity to companion patients on their spiritual journey during illness. The author, a nurse and spiritual director, relays the use of Ignatian Contemplation to help a friend journeying through the experience of renal carcinoma.

  20. The Spirituality of Q

    African Journals Online (AJOL)

    2015-07-01

    Jul 1, 2015 ... deeper communication with the divine, or stem from contemplative reflection upon one's ... In the discourse surrounding the study of religion, 'spirituality' has ..... but as an early strand of Jesus tradition, the Q source provides.

  1. Treatment of Male Sexual Offenders in a Correctional Facility.

    Science.gov (United States)

    Whitford, Robert W.

    1987-01-01

    Provides some background and treatment perspectives for counselors and psychologists who treat or contemplate treatment of adult male sexual offenders in prison settings. Discusses identification, assessment, amenability to treatment, assessment instruments, and treatment of sexual offenders. (ABL)

  2. A case study on the impact of industrial effluent disposal on the fishery of Amba River Estuary, Maharashtra

    Digital Repository Service at National Institute of Oceanography (India)

    Gajbhiye, S.N.; Mehta, P.; Mustafa, S.; Nair, V.R.

    The impact of waste discharge on fishery resources is a matter of great concern. The accepted norm in all environmental impact assessment studies is to avoid areas of high fishery potential while locating a marine outfall. Contemplating...

  3. Death and Rebirth of Atlántida: The Role of Social Learning in ...

    African Journals Online (AJOL)

    Drawing on 12 months of action-oriented research, including interviews and ..... of an added benefit. On the other hand, the 'Ying ... Moreover, time for contemplation and meditation are crucial, and thus a slower pace in activities is needed.

  4. Stages of change to increase fruit and vegetable intake and its relationships with fruit and vegetable intake and related psychosocial factors.

    Science.gov (United States)

    Chee Yen, Wong; Mohd Shariff, Zalilah; Kandiah, Mirnalini; Mohd Taib, Mohd Nasir

    2014-06-01

    Understanding individual's intention, action and maintenance to increase fruit and vegetable intake is an initial step in designing nutrition or health promotion programs. This study aimed to determine stages of change to increase fruit and vegetable intake and its relationships with fruit and vegetable intake, self-efficacy, perceived benefits and perceived barriers. This cross-sectional study was conducted among 348 public university staff in Universiti Putra Malaysia. A pre-tested self-administered questionnaire and two days 24-hour diet recall were used. Half of the respondents (50%) were in preparation stage, followed by 43% in action/maintenance, 7% in pre-contemplation/contemplation stages. Respondents in action/maintenance stages had significantly higher self-efficacy (F = 9.17, P diet high in fruits and vegetables in order to promote healthy changes in having high fruit and vegetable intake.

  5. 22 CFR 135.32 - Equipment.

    Science.gov (United States)

    2010-04-01

    ... specifically permitted or contemplated by Federal statute. (4) When acquiring replacement equipment, the...) Management requirements. Procedures for managing equipment (including replacement equipment), whether... return. (e) Disposition. When original or replacement equipment acquired under a grant or subgrant is no...

  6. 21 CFR 1403.32 - Equipment.

    Science.gov (United States)

    2010-04-01

    ... specifically permitted or contemplated by Federal statute. (4) When acquiring replacement equipment, the...) Management requirements. Procedures for managing equipment (including replacement equipment), whether... return. (e) Disposition. When original or replacement equipment acquired under a grant or subgrant is no...

  7. 45 CFR 602.32 - Equipment.

    Science.gov (United States)

    2010-10-01

    ... specifically permitted or contemplated by Federal statute. (4) When acquiring replacement equipment, the...) Management requirements. Procedures for managing equipment (including replacement equipment), whether... return. (e) Disposition. When original or replacement equipment acquired under a grant or subgrant is no...

  8. 49 CFR 18.32 - Equipment.

    Science.gov (United States)

    2010-10-01

    ... specifically permitted or contemplated by Federal statute. (4) When acquiring replacement equipment, the...) Management requirements. Procedures for managing equipment (including replacement equipment), whether... return. (e) Disposition. When original or replacement equipment acquired under a grant or subgrant is no...

  9. 34 CFR 80.32 - Equipment.

    Science.gov (United States)

    2010-07-01

    ... specifically permitted or contemplated by Federal statute. (4) When acquiring replacement equipment, the...) Management requirements. Procedures for managing equipment (including replacement equipment), whether... return. (e) Disposition. When original or replacement equipment acquired under a grant or subgrant is no...

  10. 10 CFR 600.232 - Equipment.

    Science.gov (United States)

    2010-01-01

    ... specifically permitted or contemplated by Federal statute. (4) When acquiring replacement equipment, the...) Management requirements. Procedures for managing equipment (including replacement equipment), whether... return. (e) Disposition. When original or replacement equipment acquired under a grant or subgrant is no...

  11. 45 CFR 1183.32 - Equipment.

    Science.gov (United States)

    2010-10-01

    ... specifically permitted or contemplated by Federal statute. (4) When acquiring replacement equipment, the...) Management requirements. Procedures for managing equipment (including replacement equipment), whether... return. (e) Disposition. When original or replacement equipment acquired under a grant or subgrant is no...

  12. 02 Burger 03.pmd

    African Journals Online (AJOL)

    Owner

    23 Jul 2008 ... In this novel memory and the importance of remembering is contemplated. ... process, often brings a sense of loss, but also contributes finding a way ... gemoeid met herinnering, met die wal gooi teen die verbygaan van tyd.

  13. 77 FR 26052 - Invesco Total Property Market Income Fund, et al.; Notice of Application

    Science.gov (United States)

    2012-05-02

    ... level of current income. It is currently contemplated that the common shares of the Property Fund and... disclosure required by condition 2(a)(ii) above, as an exhibit to its next filed Form N-CSR; and (c) The Fund...

  14. M-aminophenyltrialkylstannane

    International Nuclear Information System (INIS)

    Kassis, A.I.; Khawli, L.A.

    1990-01-01

    M-Radiohalo-aniline is a stable intermediate for preparing biotin-m-radiohalo-anilide to be used as an imaging agent or therapeutic agent. The invention also contemplates m-aminophenyltrialkylstannane which can be radiohalogenated and linked to biotin. No Drawings

  15. The surgical importance of an axillary arch in sentinel node biopsy.

    LENUS (Irish Health Repository)

    Ridgway, P F

    2011-03-01

    When Carl Langer described the aberrant axillary arch in 1846 its relevance in sentinel node biopsy (SNB) surgery could not have been contemplated. The authors define an incidence and elucidate relevance of the arch in SNB of the axilla.

  16. ANALYSIS OF DEPENDENCE BETWEEN CAPITAL EXPENDUTURES OF CONSTRUCTION WORKS AND GAS DISTRIBUTION PIPELINE DIAMETER

    Directory of Open Access Journals (Sweden)

    Tabunshchikov Yuriy Andreevich

    2012-10-01

    The research also contemplates the structure of expenses associated with the piping of gas distribution networks. Mathematical equations have been derived to perform sufficiently accurate calculations of costs of construction of various types and various lengths of gas pipelines.

  17. 77 FR 21574 - Prospective Grant of Exclusive License: Method for Segmenting Medical Images and Detecting...

    Science.gov (United States)

    2012-04-10

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Prospective Grant of... Institutes of Health (NIH), Department of Health and Human Services, is contemplating the grant of an... detect surface anomalies by comparing the curvature characteristics of anatomy to curvature...

  18. Petra Governance Handbook - WP7 – Governance structures & business models : D7.3: Governance Handbook

    NARCIS (Netherlands)

    Veeneman, W.; Hirschhorn, F.; Klievink, A.J.; Steenhuisen, B.M.; van der Voort, H.G.

    2017-01-01

    This document represents the governance handbook on mobility data platforms for the PETRA project. The governance handbook provides metropolitan authorities contemplating the implementation of a mobility data platform in line with the PETRA project about governance issues and design.
    The

  19. Evaluation of LES models for flow over bluff body from engineering ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    one-equation model for subgrid kinetic energy is the best choice. ... He also contemplated to use Spalart & Allmaras (1992) one-equation RANS model for this ..... characteristics of the turbulent flow near wake of a square cylinder. J. Fluid Mech ...

  20. A first approach on fault detection and isolation for cardiovascular anomalies detection

    KAUST Repository

    Ledezma, Fernando; Laleg-Kirati, Taous-Meriem

    2015-01-01

    variations in physiological parameters and deviations in the performance of the heart's mitral and aortic valves. An observer-based approach is discussed as the basis of the method. The approach contemplates a bank of Extended Kalman Filters to achieve joint

  1. 49 CFR 1180.6 - Supporting information.

    Science.gov (United States)

    2010-10-01

    ...., merger, control, purchase, trackage rights), the significant terms and conditions, and the consideration... jurisdiction, authorizing the contemplated action. (v) State whether the property involved in the proposed... enhance, competition. (i) Applicants must explain how they would preserve competitive options for shippers...

  2. Malnutrition and the disproportional burden on the poor: The case of Ghana

    NARCIS (Netherlands)

    E. Van de Poel (Ellen); A.R. Hosseinpoor (Ahmad); C. Jehu-Appiah (Caroline); J. Vega (Jeanette); N. Speybroeck (Niko)

    2007-01-01

    textabstractBackground. Malnutrition is a major public health and development concern in the developing world and in poor communities within these regions. Understanding the nature and determinants of socioeconomic inequality in malnutrition is essential in contemplating the health of populations in

  3. Cardiac safety strategies. 25-26 October 2005, the Radisson SAS Hotel, Nice, France.

    Science.gov (United States)

    Hanton, Gilles; Tilbury, Lorraine

    2006-03-01

    This meeting was organised by IIR Life Sciences. It was chaired by Brian Guth, (head of General Pharmacology at Boehringer Ingelheim Pharma) and brought together scientists and clinicians from the pharmaceutical industry, university and regulatory agencies. The meeting presented emerging trends in cardiac safety, including its regulatory context pertaining to ICH S7A, S7B and E14. ICH S7A and S7B highlight the importance of the hERG test and telemetric studies in non-rodents. ICH E14 describes the clinical 'thorough QT study' that is required by the FDA for any new drug. Marked physiological variability in QT interval over time can be observed, partly as a result of fluctuation in autonomic tone. Beat-to-beat QT variability and T-wave morphology should be considered as a part of an integrated estimate of proarrhythmic risk. A case study illustrated the predictivity of preclinical data for proarrhythmic risk in humans, showing the importance of evaluating QT effects in patients to establish a safety margin.

  4. Vol. 4 in the series: Site profiles of persistent chlorinated hydrocarbons - cause-oriented monitoring in aquatic media; Pestizide aus der Reihe der persistenten chlorierten Kohlenwasserstoffe in Gewaessern der Rhein-Region - Ergebnisse nachhaltiger Steuerungen von Wirtschaft und Politik. Bd. 4 der Reihe: Standortprofile persistenter chlorierter Kohlenwasserstoffe - ursachenorientiertes Monitoring in aquatischen Medien

    Energy Technology Data Exchange (ETDEWEB)

    Heinisch, E.; Kettrup, A.; Bergheim, W.; Wenzel, S.

    2003-07-01

    Evaluating the analytical data of DDT and its metabolites, the isomers of HCH as well as (sometimes) of aldrin and dieldrin in surface water, suspended matter, eels, breams and roaches from the rivers Rhine, Neckar, Kocher, Enz, Main (upto km 360), Weschnitz, Modau, Schwarzbach, Hengstbach, Grundbach, Nidda, Rodau, Kinzig, Werra, Diemel, Lahn, Nahe, Mosel, Sauer, Saar, Ahr, Kyll, Sieg and Laacher See distance profiles (partly from Konstanz till Markermeer) and time series (partly from 1984-2001) were elaborated. The primary data come from about 15 mainly regional investigation departments, the IKSR and the Environmental Specimen Bank. The chemical enterprises in Rheinfelden, Grenzach, Ludwigshafen, Lampertheim, Gernsheim, Darmstadt, Hoechst, Kelsterbach, Offenbach, Ingelheim, Loelsdorf, Leverkusen, Elberfeld, Krefeld-Uerdingen and Huels could partly be made transparent by the course of the sDDT and sHCH values and the profiles of the constituents and isomers, resp., in the distance profiles (especially from the river Rhine) mainly from 1990/92. The corresponding graph for the year 2000 shows that there is no longer a human and ecotoxicological relevance of the compounds to be expected. (orig.)

  5. Partners in Science: A Model Cooperative Program Introducing High School Teachers and Students to Leading-Edge Pharmaceutical Science

    Science.gov (United States)

    Woska, Joseph R., Jr.; Collins, Danielle M.; Canney, Brian J.; Arcario, Erin L.; Reilly, Patricia L.

    2005-12-01

    Partners in Science is a cooperative program between Boehringer Ingelheim Pharmaceuticals, Inc. and area high schools in the community surrounding our Connecticut campus. It is a two-phase program that introduces high school students and teachers to the world of drug discovery and leading-edge pharmaceutical research. Phase 1 involves a series of lectures, tours, and demonstrations given by scientists within our research and development division (R&D). Phase 2 involves the selection of a small group of participants to intern for the summer in a research laboratory, working side by side with a scientist within R&D. In this manuscript, the specific aims, goals, and development of the Partners in Science program are described, as well as the syllabus/agenda, the logistics surrounding the operation of the program, and our shared personal experiences with students and teachers who have participated. Some of the pitfalls/problems associated with the program will be presented, and finally, the future direction of the program including areas of improvement and expansion are described.

  6. Control of radioactive waste in dismantling of a nuclear facility; Control de residuos radiactivos en desmantelamiento de una instalacion nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Campayo, E.

    2014-07-01

    In the dismantling of a nuclear facility are generated radioactive waste that must be suitably processed. The overall process, in a simplified manner, contemplates the characterization in origin, their segregation on the basis of physical, mechanical, and radiological characteristics and their packaging. (Author)

  7. Radiation curable coatings having nonadherent surfaces

    International Nuclear Information System (INIS)

    Gaske, J.E.; Georgas, N.T.

    1977-01-01

    Radiation polymerizable coatings having nonadherent surfaces are provided utilizing nonaqueous emulsions of a liquid alkyl hydrogen polysiloxane in a radiation polymerizable polyethylenic liquid. Polyacrylates in combination with amines, and ultraviolet photosensitizers are particularly contemplated for rapid nonair inhibited ultraviolet cure. 13 claims

  8. Connections between primary vaginismus and procreation : Some observations from clinical practice

    NARCIS (Netherlands)

    Drenth, JJ; Heringa, MP; Mourits, MJE; vandeWiel, HBM; Schultz, WCMW

    1996-01-01

    So far the literature on vaginismus has mainly been contemplative. Quantitative data are scarce, while fertility and obstetrical aspects are almost never considered. In this article, these two aspects are addressed. A cohort of patients received a questionnaire, developed to obtain information about

  9. Outcome of pregnancy in women after pulmonary autograft valve replacement for congenital aortic valve disease

    NARCIS (Netherlands)

    Yap, Sing-Chien; Drenthen, Willem; Pieper, Petronella G.; Moons, Philip; Mulder, Barbara J. M.; Klieverik, Loes M.; Vliegen, Hubert W.; van Dijk, Arie P. J.; Meijboom, Folkert J.; Roos-Hesselink, Jolien W.

    Background and aim of the study: The pulmonary autograft has been recommended as the valve of choice for aortic valve replacement (AVR) in young women contemplating pregnancy. However, current information on maternal and perinatal outcome of pregnancy in women with pulmonary autograft valve

  10. Outcome of pregnancy in women after pulmonary autograft valve replacement for congenital aortic valve disease

    NARCIS (Netherlands)

    Yap, Sing-Chien; Drenthen, Willem; Pieper, Petronella G.; Moons, Philip; Mulder, Barbara J. M.; Klieverik, Loes M.; Vliegen, Hubert W.; van Dijk, Arie P. J.; Meijboom, Folkert J.; Roos-Hesselink, Jolien W.

    2007-01-01

    Background and aim of the study: The pulmonary autograft has been recommended as the valve of choice for aortic valve replacement (AVR) in young women contemplating pregnancy. However, current information on maternal and perinatal outcome of pregnancy in women with pulmonary autograft valve

  11. Congenital Aortic Stenosis in Adults: Update on clinical outcome, diagnostic methods and pregnancy

    NARCIS (Netherlands)

    S-C. Yap (Sing-Chien)

    2007-01-01

    textabstractBackground and aim of the study: The pulmonary autograft has been recommended as the valve of choice for aortic valve replacement (AVR) in young women contemplating pregnancy. However, current information on maternal and perinatal outcome of pregnancy in women with pulmonary autograft

  12. Outcome of pregnancy in women after pulmonary autograft valve replacement for congenital aortic valve disease.

    NARCIS (Netherlands)

    Yap, S.C.; Drenthen, W.; Pieper, P.G.; Moons, P.; Mulder, B.J.M.; Klieverik, L.M.; Vliegen, H.W.; Dijk, A.P.J. van; Meijboom, F.J.; Roos-Hesselink, J.W.

    2007-01-01

    BACKGROUND AND AIM OF THE STUDY: The pulmonary autograft has been recommended as the valve of choice for aortic valve replacement (AVR) in young women contemplating pregnancy. However, current information on maternal and perinatal outcome of pregnancy in women with pulmonary autograft valve

  13. 78 FR 59708 - Prospective Grant of Exclusive Commercialization License: The Use of Cysteamine for the Treatment...

    Science.gov (United States)

    2013-09-27

    ... applications for these technology families, to Raptor Pharmaceuticals, Inc. The patent rights in these... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Prospective Grant of... Institutes of Health, Department of Health and Human Services, is contemplating the grant of an exclusive...

  14. Some Sunshine for Your Fiscal Life: Solar Energy Schools May Not Be as Far Off or as Blue Sky as We've Thought

    Science.gov (United States)

    Downey, Gregg W.

    1977-01-01

    Dozens of schools throughout North America already are putting solar equipment to limited uses, scores are conducting or contemplating solar feasibility studies, and at least one school now in operation is applying solar power to every phase of its energy program. (Author)

  15. The liberation through art: a view on Indian aesthetics

    Directory of Open Access Journals (Sweden)

    Gisele Cardoso de Lemos

    2015-04-01

    Full Text Available This text reflects on the urgency to develop works that contemplate the Indian art in dialogue with spirituality, in Latin America, through India’s own theoretical sources.Keywords: aesthetics; India; Nāţyaśāstra; mokśa.

  16. 44 CFR 208.2 - Definitions of terms used in this part.

    Science.gov (United States)

    2010-10-01

    ... defined term unless such capitalization results from the application of standard capitalization or style... performance of the contemplated activity. Daily Cost Estimate means a Sponsoring Agency's estimate of Task... and Rescue (US&R), and other specialists combined to provide operations, planning, logistics, finance...

  17. S. 705: A Bill to assure fair consideration of the interests of states likely to be affected by the establishment of low-level radioactive waste disposal facilities. Introduced in the Senate of the United States, One Hundredth First Congress, First Session, April 5, 1989

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    S. 705 is a bill to assure fair consideration of the interests of states likely to be affected by the establishment of low-level radioactive waste disposal facilities. Notification of adjacent states is proposed when waste disposal operations are contemplated at border sites

  18. 78 FR 35295 - Agency Information Collection Activities: Department of Homeland Security (DHS) Cybersecurity...

    Science.gov (United States)

    2013-06-12

    ... cybersecurity awareness, education, talent management, and professional development and training. NICCS Portal... Education Office, will submit the following Information Collection Request (ICR) to the Office of Management... contemplated: Federal Information Security Management Act of 2002 (FISMA), 44 U.S.C. 3546; Homeland Security...

  19. University Students Leaving Relationships (USLR): Scale Development and Gender Differences in Decisions to Leave Romantic Relationships

    Science.gov (United States)

    Hendy, Helen M.; Can, S. Hakan; Joseph, Lauren J.; Scherer, Cory R.

    2013-01-01

    The University Students Leaving Relationships scale was developed to identify student concerns when contemplating dissolution of romantic relationships. Participants included 1,106 students who rated the importance of issues when deciding to leave relationships. Factor analysis produced three dimensions: Missing the Relationship, Social…

  20. Understanding overbidding: using the neural circuitry of reward to design economic auctions.

    Science.gov (United States)

    Delgado, Mauricio R; Schotter, Andrew; Ozbay, Erkut Y; Phelps, Elizabeth A

    2008-09-26

    We take advantage of our knowledge of the neural circuitry of reward to investigate a puzzling economic phenomenon: Why do people overbid in auctions? Using functional magnetic resonance imaging (fMRI), we observed that the social competition inherent in an auction results in a more pronounced blood oxygen level-dependent (BOLD) response to loss in the striatum, with greater overbidding correlated with the magnitude of this response. Leveraging these neuroimaging results, we design a behavioral experiment that demonstrates that framing an experimental auction to emphasize loss increases overbidding. These results highlight a role for the contemplation of loss in understanding the tendency to bid "too high." Current economic theories suggest overbidding may result from either "joy of winning" or risk aversion. By combining neuroeconomic and behavioral economic techniques, we find that another factor, namely loss contemplation in a social context, may mediate overbidding in auctions.

  1. Fabrication criteria applicable to Carem pods production

    International Nuclear Information System (INIS)

    Bianchi, D R; Azzinari, D; Gongora, P; Sabio Calvete, M; Ilarri, M; Perazzo, M; Duarte, J; Duarte, A; Rojas, J; Fleitas, G; Szieber, W C; Vizcaino, P

    2012-01-01

    In relation CAREM 25 project, PPFAE, CNEA, has been fabricated pods for fuel rods for that reactor. They were used the same fuel rods that to be irradiate and evaluate their behavior with that the same Uranium pellets. The scope of the agreement signed between the authorities of the CNEA and Institutt for Energiteknikk (IFE) in Norway, it contemplated irradiated fuel rods type CAREM fabricated from these fuel pods in the OECD Halden Reactor Project (HRP, venture led by IFE and integrate more than 16 countries). The work contemplates the production of two experimental item fuel pods. From the second item fuel pods will be used in the fuel rods. In this paper we analyze the sequences used; the results obtained and the general conditions for the development of the final process to be applied in the production phase for a reactor CAREM 25 (author)

  2. Contributions of Social Entrepreneurship to Increase the Participation of Women in the Labor Market

    Directory of Open Access Journals (Sweden)

    Vania de Fátima Barros Estivalete

    2018-05-01

    Full Text Available The objective of the study is to examine the prospect of coordinators and members of collective enterprises members of a Brazilian social incubator about the contributions of social entrepreneurship with the female increase in the participation of women in the labor market. We conducted a descriptive and qualitative research. The analysis of the context was defined a priori by defined categories, based on a theoretical model that contemplates the dimensions: human capital, will and viability, social capital, social and institutional environment actors. The categories defined a posteriori contemplated the following categories: empowerment, recovery and personal fulfillment. Regarding women's inclusion in the labor market, the results reflected some difficulties faced by women who participate in projects, with highlights to the lack of qualification, opportunities and participation in the formal market. For many interviewees, these projects represented the first opportunity for inclusion in the labor market.

  3. Association of Trans-theoretical Model (TTM based Exercise Behavior Change with Body Image Evaluation among Female Iranian Students

    Directory of Open Access Journals (Sweden)

    Sahar Rostami

    2017-03-01

    Full Text Available BackgroundBody image is a determinant of individual attractiveness and physical activity among the young people. This study was aimed to assess the association of Trans-theoretical model based exercise behavior change with body image evaluation among the female Iranian students.Materials and MethodsThis cross-sectional study was conducted in Sanandaj city, Iran in 2016. Using multistage sampling method, a total of 816 high school female students were included in the study. They completed a three-section questionnaire, including demographic information, Trans-theoretical model constructs and body image evaluation. The obtained data were fed into SPSS version 21.0.  ResultsThe results showed more than 60% of participants were in the pre-contemplation and contemplation stages of exercise behavior. The means of perceived self-efficacy, barriers and benefits were found to have a statistically significant difference during the stages of exercise behavior change (P

  4. Dos ecos do turismo aos ecos da paisagem: análises das tendências do ecoturismo e a percepção de suas paisagens

    Directory of Open Access Journals (Sweden)

    Beraldo Maciel Leme, Fernanda

    2007-01-01

    Full Text Available The present article considers the revision of the trends for the practical one of the ecoturismo in the specialized bibliography. Through also the research in sites of hotels and operators of the area one searched to complement and to verify in the practical a concretion of these trends. It was looked through the field research to define if the ecoturismo could exactly be faced in itself as a trend or if it would be possible define it as a trend that makes possible the attendance of some basic necessities of the human being, as contact with the nature, its contemplation and the necessity of the playful one through the ad-venture idea. Thus, it was analyzed perception of the young public (bigger consumer of ecoturismo regarding the landscapes and the relations of these perceptions with the subjects: ecoturismo, contempla-tion, leisure and adventure

  5. ecoturismo e a percepção de suas paisagens

    Directory of Open Access Journals (Sweden)

    Fernanda Beraldo Maciel Leme

    2007-01-01

    Full Text Available The present article considers the revision of the trends for the practical one of the ecoturismo in the specialized bibliography. Through also the research in sites of hotels and operators of the area one searched to complement and to verify in the practical a concretion of these trends. It was looked through the field research to define if the ecoturismo could exactly be faced in itself as a trend or if it would be possible define it as a trend that makes possible the attendance of some basic necessities of the human being, as contact with the nature, its contemplation and the necessity of the playful one through the adventure idea. Thus, it was analyzed perception of the young public (bigger consumer of ecoturismo regarding the landscapes and the relations of these perceptions with the subjects: ecoturismo, contemplation, leisure and adventure.

  6. Cognitive barriers to readiness to change in alcohol-dependent patients.

    Science.gov (United States)

    Le Berre, Anne-Pascale; Vabret, François; Cauvin, Céline; Pinon, Karine; Allain, Philippe; Pitel, Anne-Lise; Eustache, Francis; Beaunieux, Hélène

    2012-09-01

    Patients' personal investment and readiness to change have proved to be a prerequisite for the successful treatment of alcohol addiction. The aim of this study was to determine the contribution of cognitive functions to the motivation process to abandon maladjusted behavior in favor of a healthier lifestyle. An adapted version of the "readiness to change" questionnaire was completed by 31 alcohol-dependent patients after detoxification and at alcohol treatment entry. This tool is designed to assess the 3 main stages of motivation to change regarding alcohol consumption: precontemplation (substance abuse and no intention to stop drinking), contemplation (strong intention to change habits but ambivalent behavior), and action (cessation of excessive alcohol consumption and behavioral changes for healthier habits) stages. Patients and 37 healthy controls also underwent an extensive neuropsychological battery including episodic memory, metamemory, executive functions, and decision-making assessment. When alcohol-dependent patients were considered as a group, the mean score on the action subscale was significantly higher than the precontemplation and contemplation ones. Nevertheless, when the stage of change reached by each patient was considered individually, we found that some alcohol-dependent patients were still in the earlier precontemplation and contemplation stages. Stepwise regression analysis revealed links between impaired memory and executive functions and low motivation, and between good decision-making skills and high motivation. Our results suggest that a set of complementary cognitive abilities is needed to achieve awareness and resolve ambivalence toward alcohol addiction, which is essential for activating the desire to change problematic behavior. Copyright © 2012 by the Research Society on Alcoholism.

  7. Training tomorrow's global health leaders: applying a transtheoretical model to identify behavior change stages within an intervention for health leadership development.

    Science.gov (United States)

    Daniels, Joseph; Farquhar, Carey; Nathanson, Neal; Mashalla, Yohana; Petracca, Frances; Desmond, Michelle; Green, Wendy; Davies, Luke; O'Malley, Gabrielle

    2014-12-01

    Training health professionals in leadership and management skills is a key component of health systems strengthening in low-resource settings. The importance of evaluating the effectiveness of these programs has received increased attention over the past several years, although such evaluations continue to pose significant challenges. This article presents evaluation data from the pilot year of the Afya Bora Fellowship, an African-based training program to increase the leadership capacity of health professionals. Firstly, we describe the goals of the Afya Bora Fellowship. Then, we present an adaptation of the transtheoretical model for behavior change called the Health Leadership Development Model, as an analytical lens to identify and describe evidence of individual leadership behavior change among training participants during and shortly after the pilot year of the program. The Health Leadership Development Model includes the following: pre-contemplation (status quo), contemplation (testing and internalizing leadership), preparation - (moving toward leadership), action (leadership in action), and maintenance (effecting organizational change). We used data from surveys, in-depth interviews, journal entries and course evaluations as data points to populate the Health Leadership Development Model. In the short term, fellows demonstrated increased leadership development during and shortly after the intervention and reflected the contemplation, preparation and action stages of the Health Leadership Development Model. However, expanded interventions and/or additional time may be needed to support behavior change toward the maintenance stages. We conclude that the Health Leadership Development Model is useful for informing health leadership training design and evaluation to contribute to sustainable health organizational change. © The Author(s) 2014.

  8. Tenure Track Policy Increases Representation of Women in Senior Academic Positions, but Is Insufficient to Achieve Gender Balance

    NARCIS (Netherlands)

    Bakker, M.M.; Jacobs, M.H.

    2016-01-01

    Underrepresentation of women in senior positions is a persistent problem in universities worldwide, and a wide range of strategies to combat this situation is currently being contemplated. One such strategy is the introduction of a tenure track system, in which decisions to promote scientific staff

  9. Opportunistic-harvesting: RF wireless power transfer scheme for multiple access relays system

    NARCIS (Netherlands)

    Rajaram, A.; Jayakody, D.N.K.; Srinivasan, K.; Chen, B.; Sharma, V.

    2017-01-01

    Wireless communications have become one of the main stake holders on which our contemporary world relies for carrying out many daily activities. In this era, the number of connected devices is increasing rapidly, contemplating not only smart phone, but also growing connectivity of machines, sensors,

  10. 76 FR 81561 - Connect America Fund; A National Broadband Plan for Our Future; Establishing Just and Reasonable...

    Science.gov (United States)

    2011-12-28

    ... carriers (ETCs), and the Commission codifies it in the rules. Section 254(e) thus contemplates that...-party service, operator services, and directory assistance. 30. Today, all ETCs, whether designated by a... service--throughout their designated service area. ETCs also must provide Lifeline service throughout...

  11. 45 CFR 1174.32 - Equipment.

    Science.gov (United States)

    2010-10-01

    ... contemplated by Federal statute. (4) When acquiring replacement equipment, the grantee or subgrantee may use... requirements. Procedures for managing equipment (including replacement equipment), whether acquired in whole or... original or replacement equipment acquired under a grant or subgrant is no longer needed for the original...

  12. 45 CFR 1157.32 - Equipment.

    Science.gov (United States)

    2010-10-01

    ... contemplated by Federal statute. (4) When acquiring replacement equipment, the grantee or subgrantee may use... requirements. Procedures for managing equipment (including replacement equipment), whether acquired in whole or... original or replacement equipment acquired under a grant or subgrant is no longer needed for the original...

  13. Show Me the Money: Impact of County Funding on Retention Rates for Extension Educators

    Science.gov (United States)

    Feldhues, Katherine; Tanner, Timothy

    2017-01-01

    Extension administrators contemplating the challenge of employee turnover should consider potential motivation factors. Through the lens of Herzberg's motivation-hygiene theory, we explored the relationship between financial uncertainty and employee turnover in Ohio State University Extension. The Human Resources department and Business Office of…

  14. 78 FR 20671 - Prospective Grant of A Start-Up Commercialization Exclusive License: The Development of Fenoterol...

    Science.gov (United States)

    2013-04-05

    ... Brain and Hepatocellular Cancers AGENCY: National Institutes of Health, HHS. ACTION: Notice. SUMMARY..., and use in humans for the treatment of brain cancer or hepatocellular cancer within the Licensed... contemplated exclusive commercialization license should be directed to: Patrick McCue, Ph.D., Licensing and...

  15. 75 FR 45178 - Escalate Capital Partners SBIC I, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

    Science.gov (United States)

    2010-08-02

    ..., Financings which Constitute Conflicts of Interest of the Small Business Administration (``SBA'') Rules and... contemplated to fund the ongoing operating needs of the business. The financing is brought within the purview... SMALL BUSINESS ADMINISTRATION Escalate Capital Partners SBIC I, L.P.; Notice Seeking Exemption...

  16. Motivational Profiles of Veterans Seeking Substance Abuse Treatment: Profiles Based on Stages of Change.

    Science.gov (United States)

    Carney, Margaret M.; Kivlahan, Daniel R.

    This study replicated an earlier study which identified five subtypes of outpatient alcoholics (Uninvolved, Participation, Ambivalent, Precontemplation, Contemplation) according to the stages of change model, extending the effort to 404 polydrug users at a Veterans Administration hospital. Subjects were administered a demographic questionnaire;…

  17. 48 CFR 52.246-5 - Inspection of Services-Cost-Reimbursement.

    Science.gov (United States)

    2010-10-01

    ...-Cost-Reimbursement. 52.246-5 Section 52.246-5 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.246-5 Inspection of Services—Cost-Reimbursement. As prescribed in 46.305, insert... furnishing of services, when a cost-reimbursement contract is contemplated: Inspection of Services—Cost...

  18. 48 CFR 52.246-3 - Inspection of Supplies-Cost-Reimbursement.

    Science.gov (United States)

    2010-10-01

    ...-Cost-Reimbursement. 52.246-3 Section 52.246-3 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.246-3 Inspection of Supplies—Cost-Reimbursement. As prescribed in 46.303, insert... furnishing of supplies, when a cost-reimbursement contract is contemplated: Inspection of Supplies—Cost...

  19. On the geometry of two-dimensional anisotropic non-linear Sigma-models

    International Nuclear Information System (INIS)

    Franco, D.H.; Negrao, M.G.; Helayel Neto, J.A.; Pereira, A.R.

    1997-12-01

    One discusses here the connection between α-model gauge anomalies and the existence of a connection with torsion that does not flatten the Ricci tensor of the target manifold. The influence of an eventual anisotropy along a certain internal direction is also contemplated. (author)

  20. Driven by the future : Future time perspective across life domains and cultures

    NARCIS (Netherlands)

    Andre, L.

    2018-01-01

    Contemplating about the future is inevitable for our life and goal strivings. Consequently, Future Time Perspective (FTP) – individuals’ attitudes towards the future as a motivator for attitudes and behaviors – has been researched across disciplines and life domains. However, little is known about

  1. De meesterproef in de chirurgijnsopleiding. Een historisch concept als voorbeeld voor nu?

    NARCIS (Netherlands)

    Ijpma, Frank F. A.; van de Graaf, Robert C.; Pierik, E. G. J. M. Robert; van Gulik, Thomas M.

    2010-01-01

    AN EXAMPLE FOR THE PRESENT DAY: The current requirement for explicit quality standards and examination of surgeons is an opportunity to contemplate surgical training from a historical perspective by looking at the regulations of the Amsterdam Surgeons' Guild (1461-1736). At that time Amsterdam

  2. Treatment of the Pregnant Patient with Inflammatory Bowel Disease

    DEFF Research Database (Denmark)

    Winter, Rachel; Nørgård, Bente M; Friedman, Sonia

    2016-01-01

    a pregnant patient with a disease flare. The best way to manage women with IBD who are pregnant or contemplating pregnancy is a multidisciplinary approach. Team members often include a gastroenterologist, a high-risk obstetrician, an infertility specialist, a colorectal surgeon, and a pediatrician...

  3. 76 FR 13010 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Designation of Longer Period for...

    Science.gov (United States)

    2011-03-09

    ...; Mark G. Heesen, President, National Venture Capital Association, dated January 21, 2011; Alan F...., dated October 3, 2010; and Tom A. Alberg, Managing Director and Founder, Madrona Venture Group, dated... capitalization contemplating an initial exchange listing to raise capital, and in turn promote job creation...

  4. The social ascription of obligations to engineers

    NARCIS (Netherlands)

    Busby, J.S.; Coeckelbergh, Mark

    2003-01-01

    Discovering obligations that are ascribed to them by others is potentially an important element in the development of the moral imagination of engineers. Moral imagination cannot reasonably be developed by contemplating oneself and one’s task alone: there must be some element of discovering the

  5. The Application of Buddhist Principles to Lifelong Learning.

    Science.gov (United States)

    Johnson, Ian

    2002-01-01

    Defining lifelong learning as conscious learning taking place throughout life, Buddhist meditation, contemplation, and mindfulnes are practices suitable to developing awareness of life experience. This broadens the concept of lifelong learning beyond the narrow vocationalism and economic determinism of much current discourse. (Contains 36…

  6. Storytelling and Virtue.

    Science.gov (United States)

    Kilpatrick, William

    1997-01-01

    Emphasizes the power of storytelling, particularly heroic stories of virtue, in moral education. Provides a careful delineation of the differences between modern moral "fables" (a man contemplates stealing drugs for his dying wife) and classical stories involving heroes such as Ulysses and Galahad. (MJP)

  7. Booker T. Washington's Educational Contributions to Contemporary Practices of Sustainable Development

    Science.gov (United States)

    Grant, Brett G.

    2014-01-01

    This article discusses Booker T. Washington's educational contributions to contemporary practices of sustainable development. In particular, the article looks at Washington's contributions in the areas of economic sustainability and entrepreneurship, character development, and aesthetics. As states continue to contemplate and evaluate the value of…

  8. Triplane fracture of the distal tibial epiphysis: radiographic and CT studies

    International Nuclear Information System (INIS)

    Cone, R.O. III; Nguyen, V.; Flournoy, J.G.; Guerra, J. Jr.

    1984-01-01

    The authors analyzed six cases of triplane fracture of the ankle and reviewed the literature. A previously underscribed fracture pattern was identified in one patient. CT studies proved to be useful diagnostic tools in the evaluation of triplane fractures when operative reduction was contemplated

  9. 77 FR 44503 - Maintaining Access to Emergency Liquidity

    Science.gov (United States)

    2012-07-30

    ... Congress to provide a stability mechanism to preempt illiquidity situations before they lead to unnecessary... during times of widespread instability. By way of example, CLF figured prominently in NCUA's contingency... emergency and distressed economic circumstances. The ANPR stated that the Board was contemplating requiring...

  10. Concerns of patients actively contemplating total knee replacement: differences by race and gender.

    Science.gov (United States)

    Chang, Huan J; Mehta, Priya S; Rosenberg, Aaron; Scrimshaw, Susan C

    2004-02-15

    To examine differences by race/ethnicity and gender in patients' concerns regarding total knee replacement (TKR). Focus groups of patients actively considering TKR were conducted. Discussion included patients' questions and concerns regarding TKR. The software ATLAS.ti was used to tabulate themes by race/ethnicity and gender. Concerns raised by focus group participants were compared with thematic content from patient joint replacement information materials. This comparison used patient literature from 3 high-volume academic TKR centers, the Arthritis Foundation, and the American Academy of Orthopedic Surgeons. All groups shared similar concerns. However, some issues were more prevalent among certain gender and racial groups. For instance, concerns regarding anesthesia were more important to white Americans and concerns regarding recovery were more important to women. Some of these concerns were not addressed in the available patient literature. Different gender and racial subgroups focus on different concerns when considering TKR. These differences may contribute to gender and race/ethnicity disparity seen in TKR use.

  11. Contemplating ‘Quality Street’ : integration of environmental quality in planning sustainable urban development

    NARCIS (Netherlands)

    van Stigt, M.

    2016-01-01

    The challenge of sustainable urban development entails integration of environmental interests in decision-making about urban plans. In practice, this is not always successful. This dissertation offers explanations and suggests some strategies for further improvement. Three different perspectives are

  12. Building Character And Literacy Skills Of Primary School Students Through Puppet Contemplative Sukuraga

    Directory of Open Access Journals (Sweden)

    Iis Nurasiah

    2017-06-01

    Full Text Available Education is a process of enculturation, serves bequeath the values and achievements of the past to the future generations. Values and achievement that is the pride of the nation and the people make it known to other nations. In addition to bequeath, education also has a function to develop the cultural values and achievements of the past into the nation's cultural values corresponding to the life of the present and future, as well as developing new achievements into new character of the nation. Therefore, education, culture and national character is at the core of an educational process. literacy skills expected to provide supplies for children in reading, writing, and appreciating and responding to all types of communication. Creating literat generation requires a long process and means conducive. It begins with small and family environment, and are supported or developed in school, social environment, and the work environment. Puppet Sukuraga laden with enlightenment, education, reflection, invite people really keep up with both his body as a God-given mandate in accordance with the nature of their respective functions.

  13. The Impact of Prior Decisions on Subsequent Valuations in a Costly Contemplation Model

    OpenAIRE

    Elie Ofek; Muhamet Yildiz; Ernan Haruvy

    2007-01-01

    This paper develops and tests a model of how recall of information from past decisions affects subsequent related decisions. A boundedly rational individual has to determine her willingness to pay for a good that she previously considered purchasing at a given price, or provide valuations for a set of goods that she previously ranked in order of preference. The individual is ex ante uncertain about her utility from consumption of the goods and can exert costly cognitive effort to reduce this ...

  14. Celestial harvest 300-plus showpieces of the heavens for telescope viewing and contemplation

    CERN Document Server

    Mullaney, James

    2012-01-01

    This book describes over 300 celestial wonders that can be viewed with common binoculars and low-power ""backyard"" telescopes incorporating refractors and reflectors.In addition to such showpieces as the Andromeda Galaxy, the largest and brightest of all galaxies after the Milky Way, and the Blue Snowball, one of the autumn sky's outstanding planetary nebulas, over 20 other special objects are listed and characterized, many of which are visible to the unaided eye on a dark, clear night.The sun, moon, Venus, Mars, Jupiter, Saturn, and other members of the earth's solar system are also describ

  15. Civil Rights Continued: How History Positions Young People to Contemplate Sexuality (In)justice

    Science.gov (United States)

    Schmidt, Sandra J.

    2014-01-01

    Same-sex marriage is part of a global civil rights struggle for LGBQ rights. How this movement is framed, advanced, and critiqued across the globe can be linked to how young people in schools are prepared to deliberate social issues in the political sphere. This article examines national history books as cultural artifacts that present what is…

  16. Contemplating the murine test tube: lessons from natural killer cells and Cryptococcus neoformans.

    Science.gov (United States)

    Marr, Kaleb J; Jones, Gareth J; Mody, Christopher H

    2006-06-01

    Murine experimentation has provided many useful tools, including the ability to knockout or over-express genes and to perform experiments that are limited by ethical considerations. Over the past century, mice have imparted valuable insights into the biology of many systems, including human immunity. However, although there are many similarities between the immune response of humans and mice, there are also many differences; none is more prominent than when examining natural killer cell biology. These differences include tissue distribution, effector molecules, receptor repertoire, and cytokine responses, all of which have important implications when extrapolating the studies to the human immune responses to Cryptococcus neoformans.

  17. Contemplating Catastrophe: conveying the causes, effects, risks of and responses to global change

    Science.gov (United States)

    McCaffrey, M.; Berbeco, M.; Lahsen, M.

    2013-12-01

    Humans are changing nature and undermining the life supporting systems of the planet to an unprecedented extent, eroding more soil than all natural processes combined, fixing more nitrogen than all the bacteria on the planet, and substantially altering the land cover and chemistry of the atmosphere and waters. Yet, especially in the United States but also elsewhere, environmental awareness and policy action has been lackluster and hesitant due to a range of factors, including manufactured doubt and denial, psychological, cultural and economic investments in maintenance of status quo, and - when concern does exist - lack of knowledge about how to foster effective change. This paper will examine how recent research findings on human impacts on the planet are being conveyed to non-technical audiences and discuss challenges and opportunities to provide the public with the relevant knowledge and knowhow to address the risks of, and responses to global change. It will argue that a second-wave scientific literacy consisting in deeper understanding of the scientific process must be nurtured as part of a process to capacitate populations, especially youths, to navigate conflicting evidence and claims that surround many environmental threats. Such literacy must be fostered through 'learning conversations,' community and capacity-building, and integrated education, communication and outreach infusing science and solutions to foster a more effective approach to confronting potential catastrophe. 25 February 2013 at 16:30 Pacific Time

  18. 75 FR 79065 - Emergence Capital Partners SBIC, L.P. License No. 09/79-0454; Notice Seeking Exemption Under...

    Science.gov (United States)

    2010-12-17

    ... 95113. The financing is contemplated for working capital and general operating purposes. The financing... SMALL BUSINESS ADMINISTRATION Emergence Capital Partners SBIC, L.P. License No. 09/79-0454; Notice... hereby given that Emergence Capital Partners SBIC, L.P., 160 Bovet Road, Suite 300, San Mateo, CA 94402...

  19. 77 FR 20871 - Praesidian Capital Opportunity Fund III, LP; License No. 02/02-0647; Notice Seeking Exemption...

    Science.gov (United States)

    2012-04-06

    ... contemplated to fund working capital and capital expenditures. The financing is brought within the purview of... SMALL BUSINESS ADMINISTRATION Praesidian Capital Opportunity Fund III, LP; License No. 02/02- 0647... given that Praesidian Capital Opportunity Fund III, LP, 419 Park Avenue South, New York, NY 10016, a...

  20. 75 FR 39588 - Emergence Capital Partners SBIC, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

    Science.gov (United States)

    2010-07-09

    ..., San Jose, California 95113. The financing is contemplated for working capital and general operating... SMALL BUSINESS ADMINISTRATION [License No. 09/79-0454] Emergence Capital Partners SBIC, L.P... Notice is hereby given that Emergence Capital Partners SBIC, L.P., 160 Bovet Road, Suite 300, San Mateo...

  1. 76 FR 76474 - Emergence Capital Partners SBIC, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

    Science.gov (United States)

    2011-12-07

    ..., Emeryville, CA 94608 (``Lithium''). The financing is contemplated for working capital and general operating... SMALL BUSINESS ADMINISTRATION [License No. 09/79-0454] Emergence Capital Partners SBIC, L.P... Notice is hereby given that Emergence Capital Partners SBIC, L.P., 160 Bovet Road, Suite 300, San Mateo...

  2. 76 FR 1491 - Emergence Capital Partners SBIC, L.P. License No. 09/79-0454; Notice Seeking Exemption Under...

    Science.gov (United States)

    2011-01-10

    ... financing is contemplated for working capital and general operating purposes. The financing is brought... SMALL BUSINESS ADMINISTRATION Emergence Capital Partners SBIC, L.P. License No. 09/79-0454; Notice... hereby given that Emergence Capital Partners SBIC, L.P., 160 Bovet Road, Suite 300, San Mateo, CA 94402...

  3. 76 FR 28843 - Emergence Capital Partners SBIC, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

    Science.gov (United States)

    2011-05-18

    ... 94404. The financing is contemplated for working capital and general operating purposes. The financing... SMALL BUSINESS ADMINISTRATION [License No. 09/79-0454] Emergence Capital Partners SBIC, L.P... Notice is hereby given that Emergence Capital Partners SBIC, L.P., 160 Bovet Road, Suite 300, San Mateo...

  4. 75 FR 32230 - Emergence Capital Partners SBIC, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

    Science.gov (United States)

    2010-06-07

    ... is contemplated for working capital and general operating purposes. The financing is brought within... SMALL BUSINESS ADMINISTRATION [License No. 09/79-0454] Emergence Capital Partners SBIC, L.P... Notice is hereby given that Emergence Capital Partners SBIC, L.P., 160 Bovet Road, Suite 300, San Mateo...

  5. Government Affirmative Misrepresentation and Non-Disclosure of Superior Knowledge in Federal Contracting.

    Science.gov (United States)

    1984-09-01

    The contract in this case was for laundromat service at an overseas military installation. The contract contemplated the contractor was to build the... laundromat facilities and then immediately convey title to them since they were to be constructed on a military installation. The contract was for a

  6. 20 CFR 437.32 - Equipment.

    Science.gov (United States)

    2010-04-01

    ... contemplated by Federal statute. (4) When acquiring replacement equipment, the grantee or subgrantee may use.... Procedures for managing equipment (including replacement equipment), whether acquired in whole or in part... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Equipment. 437.32 Section 437.32 Employees...

  7. 78 FR 39345 - ACS Wireless, Inc.; Notice of Application

    Science.gov (United States)

    2013-07-01

    ... communications industry. Applicant states that, on a pro forma basis post-Transaction, its assets will consist of... providing wholesale wireless communications services to its members. The Transaction agreements contemplate... portion of the ACS Wireless' revenue. Applicant states that post-Transaction, on a pro forma basis, for...

  8. 78 FR 32547 - Loan Originator Compensation Requirements Under the Truth in Lending Act (Regulation Z...

    Science.gov (United States)

    2013-05-31

    ... adverse unintended consequences. Therefore, The Bureau further finds it has good cause pursuant to section... that it seeks comment on clarifications. (The Bureau is not contemplating extending the effective date... for an orderly transition. To allow the mortgage industry sufficient time to comply with the new rules...

  9. Regional-seasonal weather forecasting

    Energy Technology Data Exchange (ETDEWEB)

    Abarbanel, H.; Foley, H.; MacDonald, G.; Rothaus, O.; Rudermann, M.; Vesecky, J.

    1980-08-01

    In the interest of allocating heating fuels optimally, the state-of-the-art for seasonal weather forecasting is reviewed. A model using an enormous data base of past weather data is contemplated to improve seasonal forecasts, but present skills do not make that practicable. 90 references. (PSB)

  10. Disengaging from Unattainable Career Goals and Reengaging in More Achievable Ones

    Science.gov (United States)

    Creed, Peter A.; Hood, Michelle

    2014-01-01

    Participants were 181 university students who completed measures of career development (self-efficacy, perceived barriers, distress, planning, and exploration) and goal adjustment capacity (disengagement and reengagement). We expected (a) that when contemplating unachievable goals, those with a higher capacity to adjust their goals (i.e., to…

  11. 48 CFR 46.710 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... QUALITY ASSURANCE Warranties 46.710 Contract clauses. The clauses and alternates prescribed in this... research and development contract is contemplated and the use of a warranty clause has been approved under... performance specifications or design are of major importance; a fixed-price supply, service, or research and...

  12. Validation of Clay Modeling as a Learning Tool for the Periventricular Structures of the Human Brain

    Science.gov (United States)

    Akle, Veronica; Peña-Silva, Ricardo A.; Valencia, Diego M.; Rincón-Perez, Carlos W.

    2018-01-01

    Visualizing anatomical structures and functional processes in three dimensions (3D) are important skills for medical students. However, contemplating 3D structures mentally and interpreting biomedical images can be challenging. This study examines the impact of a new pedagogical approach to teaching neuroanatomy, specifically how building a…

  13. Progenitor cell-based treatment of glial disease

    DEFF Research Database (Denmark)

    Goldman, Steven A

    2017-01-01

    -based neurodegenerative conditions may now be compelling targets for cell-based therapy. As such, glial cell-based therapies may offer potential benefit to a broader range of diseases than ever before contemplated, including disorders such as Huntington's disease and the motor neuron degeneration of amyotrophic lateral...

  14. Teaching Mindfulness to Year Sevens as Part of Health and Personal Development

    Science.gov (United States)

    Arthurson, Kathy

    2015-01-01

    Recently the adoption of mindfulness or contemplative based approaches has escalated across many sectors, including in education. Proponents argue that mindfulness based teaching programs improve students' life skills, provide emotional balance, reduce stress and enhance classroom climate. To date though there is little evaluation or knowledge of…

  15. 48 CFR 52.246-8 - Inspection of Research and Development-Cost-Reimbursement.

    Science.gov (United States)

    2010-10-01

    ... Development-Cost-Reimbursement. 52.246-8 Section 52.246-8 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.246-8 Inspection of Research and Development—Cost-Reimbursement. As prescribed in... (b) a cost-reimbursement contract is contemplated; unless use of the clause is impractical and the...

  16. Five Contemporary Novelists' Views of Growing Up Turkish in the 1980s: A Literary Sociology. Occasional Papers. Turkish Studies Series Number Five.

    Science.gov (United States)

    Stone, Frank Andrews

    Literary sociology is a multifaceted process of analyzing texts. It moves beyond traditional literary criticism to incorporate such varied approaches as: appreciating literary schemata; textual analysis; seeking form, sound, and content regularities; examining the lasting values of the work; and contemplating the reader's own authentic life-world…

  17. 75 FR 3492 - Agency Information Collection Activities: Comment Request

    Science.gov (United States)

    2010-01-21

    ... underrepresentation and inadequate advancement of women,'' and ``gender equity outcomes,'' for STEM faculty. We hope that the Program does not contemplate the use of quotas, numerical goals, or other discrimination or... government agencies (see Mississippi University for Women v. Hogan, 458 U.S. 718 (1982) (gender...

  18. Four Stories: People, Communities and Sustainability. Environments for Life Conservation Issues Forum Series.

    Science.gov (United States)

    Pearson, Andrew

    Education about sustainability is the foundation of conservation efforts. This publication was designed to inform and inspire individuals and communities that may be contemplating or already undertaking efforts to promote community sustainability. The four stories in this booklet are: (1) "Coastal Community Connections"; (2) "Cultivating Farm…

  19. 45 CFR 650.7 - Awards affected by international agreements.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Awards affected by international agreements. 650.7 Section 650.7 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE... research performer such rights in any subject invention as are contemplated in the international agreement...

  20. Chronic Pharyngitis And Multiple Soft Palate Peforation In An HIV ...

    African Journals Online (AJOL)

    This report is at advocating the need for repeated investigation and screening for HIV particularly when there is persistent clinical feature strongly suggestive of AIDS. Should we even start to contemplate therapeutic of antiretroviral dugs in some cases? KEY WORDS: Chronic pharyngitis, Soft palate perforation, AIDS, HIV ...

  1. Triple-layer midface lifting : long-term follow-up of an effective approach to aesthetic surgery of the lower eyelid and the midface

    NARCIS (Netherlands)

    Stevens, Hieronymus P. Jerome D.; Willemsen, Joep C. N.; Durani, Piyush; Rasteiro, David; Omoruyi, Ogbe J.

    BACKGROUND: It is becoming more and more accepted that better aesthetic results can be obtained when the lower eyelid is considered as part of the midface when contemplating surgical rejuvenation. Descent of the orbicularis muscle and midface tissue causes malar bags, loss of volume over the

  2. Social Class (In)Visibility and the Professional Experiences of Middle-Class Novice Teachers

    Science.gov (United States)

    Hall, David; Jones, Lisa

    2013-01-01

    This article focuses upon the classed and early professional experiences of middle-class novice teachers in England experiencing and contemplating working in schools serving socio-economically disadvantaged communities. Through an examination of the visibility and invisibility of social class in education set within an increasingly unequal and…

  3. Patient satisfaction with the perioperative surgical services and ...

    African Journals Online (AJOL)

    Introduction: Globally, increasing consideration has been given to the assessment of patient satisfaction as a method of monitor of the quality of health care provision in the health institutions. Perioperative patient satisfaction has been contemplated to be related with the level of postoperative pain intensity, patients' ...

  4. A Framework for Assessing Continuing Professional Development Activities for Satisfying Pharmacy Revalidation Requirements

    Science.gov (United States)

    Donyai, Parastou; Alexander, Angela M.; Denicolo, Pam M.

    2013-01-01

    Introduction: The United Kingdom's pharmacy regulator contemplated using continuing professional development (CPD) in pharmacy revalidation in 2009, simultaneously asking pharmacy professionals to demonstrate the value of their CPD by showing its relevance and impact. The idea of linking new CPD requirements with revalidation was yet to be…

  5. Communications Satellite Receiver Systems for Public Schools: A Technical Primer.

    Science.gov (United States)

    Texas Education Agency, Austin.

    Designed to aid school districts contemplating use of some of the telecommunications services now available by satellite, this document contains information on home satellite receiving dishes (Television Receive-Only--TVROs), which can receive radio signals carrying television, sound, and data. This information includes: some factors involved in…

  6. Do prevailing theories sufficiently explain perceptions and health-seeking behavior of Ghanaians?

    NARCIS (Netherlands)

    Fenenga, Christine J.; Boahene, Kwasi; Arhinful, Daniel; de Wit, Tobias Rinke; Hutter, Inge

    2014-01-01

    The challenges faced by African countries that have pioneered a national health insurance scheme (NHIS) and the lessons learned can be of great value to other countries, contemplating the introduction of such a health financing system. In 2003, Ghana initiated the NHIS to provide access to

  7. Do prevailing theories sufficiently explain perceptions and health-seeking behavior of Ghanaians?

    NARCIS (Netherlands)

    Fenenga, Christine J.; Boahene, Kwasi; Arhinful, Daniel; de Wit, Tobias Rinke; Hutter, Inge

    The challenges faced by African countries that have pioneered a national health insurance scheme (NHIS) and the lessons learned can be of great value to other countries, contemplating the introduction of such a health financing system. In 2003, Ghana initiated the NHIS to provide access to

  8. Herbert Marcuse, Grandfather of the New Left.

    Science.gov (United States)

    Bourne, Tom

    1979-01-01

    A little over ten years ago, Herbert Marcuse found himself in the cross fire of the student movement. The radical right saw in Marcuse an incitement to revolutionary action, but individualism distinguished him from doctrinaire Marxists. He upheld the importance of pure contemplation and theory. (MLW)

  9. Liturgy as space for anticipation

    African Journals Online (AJOL)

    2011-05-04

    May 4, 2011 ... It is anticipation without answer; expectation without event ... conversing, arguing, singing, playing games, exercising, swapping hats and contemplating suicide. In effect, they ... of time, as it is about the infinituding of time and people's experience .... could include all four of the aforementioned categories. In.

  10. 12 CFR 19.131 - Notice of charges and answer.

    Science.gov (United States)

    2010-01-01

    ... PROCEDURE Disciplinary Proceedings Involving the Federal Securities Laws § 19.131 Notice of charges and... associated person. The notice must indicate the type of disciplinary action being contemplated and the... representative shall be deemed to have consented to the issuance of a disciplinary order. (b) All proceedings...

  11. 29 CFR 1990.151 - Model standard pursuant to section 6(b) of the Act.

    Science.gov (United States)

    2010-07-01

    ...) The employer shall assure that in the regulated area, food or beverages are not present or consumed... ___; (B) Engineering plans and other studies contemplated or used to determine the controls for each... circumstances). Whenever food or beverages are consumed in the workplace, the employer shall provide lunchroom...

  12. Online Inclusive Pedagogy: A Call-and-Response Dialogue on Digital Storytelling

    Science.gov (United States)

    Alcalá, Janet Ceja; Austin, Megan; Granroth, Mona; Hewitt, Breanne

    2016-01-01

    We propose digital storytelling as a pedagogical tool for online Library and Information Science education that recognizes diversity and fosters reflection among students and teacher. In a course titled Documenting Diverse Cultures and Communities, students contemplated their role as future information professionals and produced a short digital…

  13. Audit quality and inspection in the Netherlands: The importance of an intellectual approach to experiential learning and practice advancement

    NARCIS (Netherlands)

    Humphrey, C.; Canning, M.; O'Dwyer, B.

    2018-01-01

    Recent reported failings of audit practice and the extent of fines and sanctions issued against major audit firms in the Netherlands have resulted in severe criticism of the Dutch accounting profession. This paper contemplates how a noted Dutch tradition of excellence in auditing has shifted to one

  14. Efficacy and tolerability of a single-pill combination of telmisartan 80 mg and hydrochlorothiazide 25 mg according to age, gender, race, hypertension severity, and previous antihypertensive use: planned analyses of a randomized trial

    Directory of Open Access Journals (Sweden)

    Zhu D

    2013-04-01

    Full Text Available Dingliang Zhu,1 Harold Bays,2 Pingjin Gao,1 Michaela Mattheus,3 Birgit Voelker,3 Luis M Ruilope4 1Shanghai Ruijin Hospital, Shanghai, People’s Republic of China; 2Louisville Metabolic and Atherosclerosis Research Center Inc, Louisville, KY, USA; 3Boehringer Ingelheim International GmbH, Ingelheim, Germany; 4Hospital 12 de Octubre, Madrid, Spain Background: The purpose of this work was to describe the efficacy and safety of a telmisartan 80 mg + hydrochlorothiazide 25 mg (T80/H25 single-pill combination therapy in patients with moderate-severe hypertension (mean seated trough cuff systolic blood pressure [BP] ≥ 160 mmHg and diastolic BP ≥ 100 mmHg in specific patient subpopulations. Methods: This was a planned analysis of a double-blind, multicenter, parallel-group trial that demonstrated the superiority of a single-pill combination of T80/H25 versus T80 monotherapy in terms of systolic BP change from baseline to week 7. Subpopulations included older (aged ≥ 65 years versus younger, gender, race, hypertension severity, and prior antihypertensive therapy. Endpoints were change from baseline in mean seated trough cuff systolic and diastolic BP, proportion of patients achieving their BP goal (systolic/diastolic BP 30 mmHg and >40 mmHg. Results: Across all subgroups, the T80/H25 single-pill combination provided consistently greater systolic and diastolic BP reductions than T80 and more patients had systolic BP reductions of >30 mmHg. In the T80 and T80/H25 groups, BP control was achieved in 34.1% and 48.8% of men, 35.5% and 62.7% of women, 34.5% and 56.6% of Asians, 22.6% and 38.6% of blacks, 36.7% and 57.8% of whites, 36.9% and 57.5% of patients < 65 years, 29.3% and 49.3% ≥65 years, 44.2% and 66.2% of those with grade 2 hypertension, 20.4% and 39.4% of those with grade 3 hypertension, 38.9% and 53.2% of previously untreated patients, 38.1% and 62.5% of patients previously treated with one antihypertensive, and 29.7% and 48.9% of patients

  15. Tiotropium HandiHaler® and Respimat® in COPD: a pooled safety analysis

    Directory of Open Access Journals (Sweden)

    Halpin DMG

    2015-02-01

    Full Text Available David MG Halpin,1 Ronald Dahl,2 Christoph Hallmann,3 Achim Mueller,3 Donald Tashkin4 1NHS SW, Royal Devon and Exeter Hospital, Exeter, Devon, England, UK; 2Allergy Centre, Odense University Hospital, Odense, Denmark; 3Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim am Rhein, Germany; 4Department of Medicine, David Geffen School of Medicine UCLA, Los Angeles, CA, USAIntroduction: Tiotropium is prescribed for the treatment of chronic obstructive pulmonary disease (COPD and delivered via HandiHaler® (18 µg once daily or Respimat® Soft Mist™ inhaler (5 µg once daily. The recent TIOtropium Safety and Performance In Respimat® (TIOSPIR™ study demonstrated that both exhibit similar safety profiles. This analysis provides an updated comprehensive safety evaluation of tiotropium® using data from placebo-controlled HandiHaler® and Respimat® trials.Methods: Pooled analysis of adverse event (AE data from tiotropium HandiHaler® 18 µg and Respimat® 5 µg randomized, double-blind, parallel-group, placebo-controlled, clinical trials in patients with COPD (treatment duration ≥4 weeks. Incidence rates, rate ratios (RRs, and 95% confidence intervals (CIs were determined for HandiHaler® and Respimat® trials, both together and separately.Results: In the 28 HandiHaler® and 7 Respimat® trials included in this analysis, 11,626 patients were treated with placebo and 12,929 with tiotropium, totaling 14,909 (12,469 with HandiHaler®; 2,440 with Respimat® patient-years of tiotropium exposure. Mean age was 65 years, and mean prebronchodilator forced expiratory volume in 1 second (FEV1 was 1.16 L (41% predicted. The risk (RR [95% CI] of AEs (0.90 [0.87, 0.93] and of serious AEs (SAEs (0.94 [0.89, 0.99] was significantly lower in the tiotropium than in the placebo group (HandiHaler® and Respimat® pooled results, and there was a numerically lower risk of fatal AEs (FAEs (0.90 [0.79, 1.01]. The risk of cardiac AEs (0.93 [0.85, 1.02] was numerically

  16. Extending juvenility in grasses

    Energy Technology Data Exchange (ETDEWEB)

    Kaeppler, Shawn; de Leon Gatti, Natalia; Foerster, Jillian

    2017-04-11

    The present invention relates to compositions and methods for modulating the juvenile to adult developmental growth transition in plants, such as grasses (e.g. maize). In particular, the invention provides methods for enhancing agronomic properties in plants by modulating expression of GRMZM2G362718, GRMZM2G096016, or homologs thereof. Modulation of expression of one or more additional genes which affect juvenile to adult developmental growth transition such as Glossy15 or Cg1, in conjunction with such modulation of expression is also contemplated. Nucleic acid constructs for down-regulation of GRMZM2G362718 and/or GRMZM2G096016 are also contemplated, as are transgenic plants and products produced there from, that demonstrate altered, such as extended juvenile growth, and display associated phenotypes such as enhanced yield, improved digestibility, and increased disease resistance. Plants described herein may be used, for example, as improved forage or feed crops or in biofuel production.

  17. Stages of Behavioral Change for Physical Activity in High School Students: Prevalence and Associated Sociodemographic Factors.

    Science.gov (United States)

    Nunes, Heloyse E G; Silva, Diego A S

    2016-10-01

    The aim was to estimate the prevalence of stages of change for physical activity and associated sociodemographic factors in students. The sample consisted of 942 students (44.7% males, 55.3% females; mean age = 16.1 years, SD = 1.1) in southern Brazil. Self-administered questionnaire was applied to identify stages of behavioral change for physical activity and sociodemographic variables (gender, age, maternal schooling, economic status, and school shift). Multinomial logistic regression was used to estimate the odds ratio (95%). Results showed that 9.6% were in the pre-contemplation stage, 18.4% in the contemplation, 17.6% in the preparation, 14.3% in the action, and 39.6% in the maintenance stages. Girls and adolescents with lower economic status were more likely to be at stages of behavioral risk. Students whose mothers had high education were more likely to be in the action stage. © The Author(s) 2016.

  18. Experimental investigation of modal interactions in a beam-mass structure using bispectrum

    International Nuclear Information System (INIS)

    Khan, K.A.

    2001-01-01

    Observations and results pertaining to experiments with a beam-mass structure are presented. The experiments were conducted with the objective of understanding and characterizing the nonlinear interactions that occur during the motions of the structure, through the use of third-order spectra (bispectrum and bicoherence spectrum). The structure, tuned for two-to-one internal (autoparametric) resonance between its first two modes. was harmonically excited. The effect of misalignment between the components of the structure on bispectrum was also contemplated. The experimental results are provided in the form of frequency spectra, phase portraits, frequency-response curves, bispectra, and bicoherence spectra. Experimental observations of transitions from periodic to modulated motions are also presented. The potential of bispectral estimates for detecting the quadratic phase coupling among the participating modes during bifurcations and modulated motions is also contemplated. The current study is also relevant to other parametrically resonant structures like ships, rings, shells, and arches, etc. (author)

  19. 78 FR 45592 - DeltaPoint Capital IV, LP;

    Science.gov (United States)

    2013-07-29

    ..., Suite 160, Pittsford, NY 14534. The financing was contemplated for working capital. The financing is... SMALL BUSINESS ADMINISTRATION [License No. 02/02-0662] DeltaPoint Capital IV, LP; Notice Seeking... given that DeltaPoint Capital IV, L.P., 45 East Avenue, 6th Floor, Rochester, NY 14604, Federal...

  20. The universe from scratch

    NARCIS (Netherlands)

    Ambjørn, J.; Jurkiewicz, J.; Loll, R.

    2005-01-01

    A fascinating and deep question about nature is what one would see if one could probe space and time at smaller and smaller distances. Already the 19th-century founders of modern geometry contemplated the possibility that a piece of empty space that looks completely smooth and structureless to

  1. Fear and guilt in proposers : Using emotions to explain offers in ultimatum bargaining

    NARCIS (Netherlands)

    Nelissen, R.M.A.; Leliveld, M.C.; van Dijk, E; Zeelenberg, M.

    We argue that offers in bargaining are guided by the emotions that proposers anticipate when contemplating their offers. In particular, we reason that positive offers may be driven by fear and guilt, where fear is more related to the perceived consequences of having one's offer rejected, and guilt

  2. The Commission Game: An Ethics Activity for Professional Selling Courses

    Science.gov (United States)

    Milewicz, Chad

    2012-01-01

    The Commission Game is an experiment-based experiential learning activity designed to elicit students' sincere ethical decision making in an ambiguous sales context. The activity includes multiple relevant stakeholders as well as tangible, shared risk/reward elements. The activity's design encourages students to contemplate their own personal code…

  3. 12 CFR 618.8320 - Data regarding borrowers and loan applicants.

    Science.gov (United States)

    2010-01-01

    ... in a consumer report from a consumer reporting agency shall be advised as required in section 615(a...; and reports of inspectors, fieldmen, investigators, and appraisers. (b) The requirements of paragraph... organization for its confidential use in contemplation of the extension of credit or to a consumer reporting...

  4. The Etiology of Cleft Palate: a 50 year search for mechanistic and molecular understanding

    Science.gov (United States)

    Dates of special, historical significance, such as the 50th anniversary of the founding of the Teratology Society, prompt a desire to pause and look back and contemplate where we began, how far we have come, and consider the future for our scientific endeavors. The study of the e...

  5. 7 CFR 1220.212 - Duties.

    Science.gov (United States)

    2010-01-01

    ... administrative functions as it may deem necessary and define the duties and determine the compensation of each... information, and industry information programs contemplated therein. (g) To maintain such books and records... accounting with respect to the receipt and disbursement of all funds entrusted to it. (h) With the approval...

  6. Colombian mining legislation; Legislacion minera colombiana

    Energy Technology Data Exchange (ETDEWEB)

    Mendoza Delgado, Eva Isolina

    2004-07-01

    The paper makes a historical recount of the mining legislation in Colombia, it is about the more relevant aspects of the Code of Mines, like they are the title miner, obligations, economic aspects, integration of mining areas and of the benefits contemplated in the law 685 of 2001.

  7. Colombian mining legislation

    International Nuclear Information System (INIS)

    Mendoza Delgado, Eva Isolina

    2004-01-01

    The paper makes a historical recount of the mining legislation in Colombia, it is about the more relevant aspects of the Code of Mines, like they are the title miner, obligations, economic aspects, integration of mining areas and of the benefits contemplated in the law 685 of 2001

  8. ''Your Big Wedding Day''. Temporal Goal in Church Marriage Rituals

    NARCIS (Netherlands)

    Robinson, R.; Hermans, C.A.M.; Scheepers, P.L.H.; Schilderman, J.B.A.M.

    2007-01-01

    In this contribution the authors explore notions about the origin and destiny of bridal couples’ relationships from participants’ views of church marriage rituals. A church wedding can be a pivotal moment in a bridal couple’s life, and on these occasions people tend to contemplate the past and the

  9. 48 CFR 1652.204-74 - Large provider agreements.

    Science.gov (United States)

    2010-10-01

    ... FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CLAUSES AND FORMS CONTRACT CLAUSES Texts of FEHBP... Large Provider Agreement; and (ii) Not less than 60 days before exercising a renewal or other option, or... exercising a simple renewal or other option contemplated by a Large Provider Agreement that OPM previously...

  10. Hypnosis and Education.

    Science.gov (United States)

    Dale, Ralph Alan

    Hypnosis is a state of mind which manifests a high degree of suggestibility. Advertising, political campaigning, and religious contemplation are all areas in which hypotism is employed, usually without knowledge on the part of either the "hypnotist" or the subject. Because of its association with entertainment, magic, manipulation, and…

  11. Ganzua: A Cryptanalysis Tool for Monoalphabetic and Polyalphabetic Ciphers

    Science.gov (United States)

    Garcia-Pasquel, Jesus Adolfo; Galaviz, Jose

    2006-01-01

    Many introductory courses to cryptology and computer security start with or include a discussion of classical ciphers that usually contemplates some cryptanalysis techniques used to break them. Ganzua (picklock in Spanish) is an application designed to assist the cryptanalysis of ciphertext obtained with monoalphabetic or polyalphabetic ciphers.…

  12. 32 CFR 644.157 - Procedures.

    Science.gov (United States)

    2010-07-01

    ... Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE... conditions apply: (1) A Real Estate Directive has been issued on an Army (military) or Air Force project, or... acquisition of the necessary interests in real estate. If final acquisition is not contemplated within six...

  13. Water and Life on Mars: Exploring the Possibilities through an Astronomy Laboratory

    Science.gov (United States)

    Wilhelm, Ronald; Wilhelm, Jennifer

    2004-01-01

    Nontraditional laboratories can provide primary pathways by which students comprehend and apply modern astronomy. To teach a nontraditional astronomy lab, we must give students opportunities to critically contemplate unsolved questions and evaluate current data sources. In doing so, students can develop their own conjectures that will lead to…

  14. Poverty, Dependence, Optimizing, and Adapting : Material and Spiritual Poverty

    NARCIS (Netherlands)

    Sarot, Marcel; Speelman, Willem Marie

    2017-01-01

    In the preparations of this project, there have been some serious objections against the approach of poverty as a spiritual path. Sarot argues that Christians should listen carefully to these criticisms, for ideals may easily cover up realities of evil, and, in response, contemplates the use of the

  15. Who Needs Theory Anyway? The Relationship between Theory and Practice of Music Education in a Philosophical Outlook

    Science.gov (United States)

    Westerlund, Heidi; Vakeva, Lauri

    2011-01-01

    For a practicing arts educator, the relationship between theory and practice is often unproblematic: theory is considered to be irrelevant for the good practice. Considering the matter from an academic standpoint, one faces the distinction between poietic, or productive, and contemplative, or responsive, mindsets stemming from the classical…

  16. The Network Concept of Creativity and Deep Thinking: Applications to Social Opinion Formation and Talent Support

    Science.gov (United States)

    Csermely, Peter

    2017-01-01

    Our century has unprecedented new challenges, which need creative solutions and deep thinking. Contemplative, deep thinking became an "endangered species" in our rushing world of Tweets, elevator pitches, and fast decisions. Here, we describe how important aspects of both creativity and deep thinking can be understood as network…

  17. A Matter of Mindfulness.

    Science.gov (United States)

    Jacobs, Richard M.

    1998-01-01

    Advises Catholic school principals to find a quiet place each day where distractions can be placed aside for 15 minutes to contemplate spirituality. Argues that by allowing their relationship with God to permeate their busy administration, principals' mindfulness can help foster school spirituality by providing catechetical leadership for their…

  18. The Perceived Relationship between Physical Attractiveness and Social Influence Effectiveness.

    Science.gov (United States)

    Longo, Laura C.; Ashmore, Richard D.

    The power of beauty has been contemplated by writers, poets, and philosophers for centuries. The link between the target physical attractiveness and perceived social influence effectiveness has not been directly and systematically investigated. The goal of this study was to assess whether physically attractive (versus unattractive) individuals are…

  19. The Lawyer-Therapist Consultation Team.

    Science.gov (United States)

    Korelitz, Ann; Schulder, Diane

    1982-01-01

    Discusses a pilot study in which joint consultations with a family therapist and a matrimonial attorney were offered to 10 couples and one woman contemplating divorce. Videotaped sessions. Suggests joint consultations can be useful in helping couples understand the psychological and legal implications of conflicts expressed during separation.…

  20. Meditation in Higher Education: Does It Enhance Cognition?

    Science.gov (United States)

    Helber, Casey; Zook, Nancy A.; Immergut, Matthew

    2012-01-01

    We predicted that students in a sociology course that included contemplative practices (i.e., mindfulness meditation) would show an increase in performance on higher level cognitive abilities (executive functions) over the semester compared to a control group of students. Change in executive functions performance was not significantly different…

  1. How Children and Adults Represent God's Mind

    Science.gov (United States)

    Heiphetz, Larisa; Lane, Jonathan D.; Waytz, Adam; Young, Liane L.

    2016-01-01

    For centuries, humans have contemplated the minds of gods. Research on religious cognition is spread across sub-disciplines, making it difficult to gain a complete understanding of how people reason about gods' minds. We integrate approaches from cognitive, developmental, and social psychology and neuroscience to illuminate the origins of…

  2. Carbon Emissions Trading and Combined Heat and Power Strategies: Unintended Consequences

    Science.gov (United States)

    Tysseling, John C.; Vosevich, Mary; Boersma, Benjamin R.; Zumwalt, Jefferey A.

    2009-01-01

    Facility professionals continuously search for projects that reduce energy consumption and operating costs so as to directly benefit their bottom line. Many institutions nationwide have contemplated or made investments in combined heat and power (CHP) projects as a life-cycle strategy to minimize operating costs. However, recent sustainability and…

  3. The Ghosts of Counseling Psychology: Is Counseling Research Really Dead?

    Science.gov (United States)

    Murdock, Nancy L.

    2011-01-01

    Scheel et al. offer an interesting analysis on the publication rate of counseling-related research articles in counseling psychology's two major journals. In this reaction to their work, the author considers various aspects of their results and contemplates possible explanations for the decline of counseling-related publications. The author…

  4. Nederlandstalige meditatieve levens van Jezus op de vroege drukpers: een terreinverkenning

    NARCIS (Netherlands)

    Goudriaan, K.

    2007-01-01

    This contribution analyses a corpus of 29 meditative Lives of Jesus, which present a narrative element in a setting of contemplation or prayer. They can be divided into two basic forms: an 'epical' type, in which the subject matter - borrowed from the gospels and the apocrypha - is supplemented with

  5. The "Language Barrier" in Private Online Tutoring: From an Innocuous Concept to a Neoliberal Marketing Tool

    Science.gov (United States)

    Kozar, Olga

    2014-01-01

    The "language barrier" is a common buzzword in Russian-English teaching discourse that has not yet been critically investigated. This study contemplates a recently emerging phenomenon of private online language tutoring in Russia through investigation of this popular phrase. The paper draws on Critical Discourse Analysis to explore…

  6. Stage of change and motivation to healthier lifestyle in non-alcoholic fatty liver disease.

    Science.gov (United States)

    Centis, Elena; Moscatiello, Simona; Bugianesi, Elisabetta; Bellentani, Stefano; Fracanzani, Anna Ludovica; Calugi, Simona; Petta, Salvatore; Dalle Grave, Riccardo; Marchesini, Giulio

    2013-04-01

    Healthy diet and physical activity are the treatment cornerstones of non-alcoholic fatty liver disease (NAFLD); their effectiveness is however limited by difficulties in implementing lifestyle changes. We aimed at determining the stage of change and associated psychological factors as a prerequisite to refine strategies to implement behavior changes. We studied 138 consecutive NAFLD patients (73% male, age 19-73 years). The diagnosis was confirmed by liver biopsy in 64 cases (steatohepatitis, 47%). All cases completed the validated EMME-3 questionnaire, consisting of two parallel sets of instruments (for diet and physical activity, respectively) and providing stages of change according to transtheoretical model. Logistic regression analysis was used to identify factors associated with stages making behavioral changes more demanding. The individual profiles were variable; for diet, no cases had precontemplation as prevalent stage of change (highest score in individual profiles); 36% had contemplation. For physical activity, 50% were classified in either precontemplation or contemplation. Minor differences were recorded in relation to associated metabolic complications or steatohepatitis. Logistic regression identified male sex (odds ratio, 4.51; 95% confidence interval, 1.69-12.08) and age (1.70; 1.20-2.43 per decade) as the independent parameters predicting precontemplation or contemplation for diet. No predictors were identified for physical activity. NAFLD cases have scarce readiness to lifestyle changes, particularly with regard to physical activity. Defining stages of change and motivation offers the opportunity to improve clinical care of NAFLD people through individual programs exploiting the powerful potential of behavioral counseling, an issue to be tested in longitudinal studies. Copyright © 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

  7. Associação entre estágios de mudança de comportamento relacionados à atividade física e estado nutricional em universitários Association between stages of behavior change related to physical activity and nutritional status in university students

    Directory of Open Access Journals (Sweden)

    Alberto Saturno Madureira

    2009-10-01

    Full Text Available Este estudo objetivou verificar a associação entre os estágios de mudança de comportamento e o estado nutricional junto a 862 universitários. Para a classificação do estado nutricional, utilizaram-se pontos de corte para o índice de massa corporal, segundo padronização internacional. Os estágios de mudança de comportamento foram analisados individualmente e agrupados em ativos (ação, manutenção e inativos (pré-contemplação, contemplação, preparação. Proporção mais elevada de universitários foi encontrada nos estágios contemplação (32% e preparação (29,5%. Observou-se que 68,4% dos universitários eram inativos. As prevalências de baixo peso, sobrepeso e obesidade foram, respectivamente, de 9,5%, 12,4% e 1,7%. Os universitários do estágio Pré-contemplação apresentaram, respectivamente, 5,99 (IC95%: 2,29-15,68 e 7,98 (IC95%: 1,41-45,32 vezes mais chance de terem baixo peso e sobrepeso. Os resultados encontrados no presente estudo sugerem que a universidade tem papel fundamental na adoção de planos e ações voltados para o meio acadêmico, promovendo modificação no estilo de vida mediante programas de atividade física.This study aimed to verify the association between stages of behavior change related to physical activity and nutritional status among 862 university students. Body mass index cut-off values were used to classify nutritional status. Stages of behavior change were analyzed individually and classified into active (action, maintenance and inactive (pre-contemplation, contemplation, preparation. The most prevalent stages of behavior change were contemplation (32% and preparation (29.5%. Among the entire sample of students, 68.4% were inactive. Prevalence rates for underweight, overweight, and obesity were 9.5%, 12.4%, and 1.7%, respectively. Students classified in the pre-contemplation stage were 5.99 times (CI95%: 2.29-15.68 and 7.98 times (CI95%: 1.41-45.32 more likely to be underweight and

  8. Suicidal behaviours in male and female users of illicit drugs recruited in drug treatment facilities

    Directory of Open Access Journals (Sweden)

    Elisabet Arribas-Ibar

    2017-07-01

    Conclusions: Prevalence of suicidal ideation/plans was high among illicit drug users recruited from healthcare facilities. Besides psychological variables, participation in illegal market activities and crime ought to be considered in drug users’ suicidal prevention. Suicide risk needs to be evaluated in drug treatment facilities and psychological status and context contemplated.

  9. 78 FR 32294 - Escalate Capital Partners SBIC I, L.P., License No. 06/06-0335; Notice Seeking Exemption Under...

    Science.gov (United States)

    2013-05-29

    ..., Suite 309, Austin, TX 78730. The financing is contemplated to provide working capital. The financing is... SMALL BUSINESS ADMINISTRATION Escalate Capital Partners SBIC I, L.P., License No. 06/06-0335... Notice is hereby given that Escalate Capital Partners, SBIC I, L.P., 300 W. 6th Street, Suite 2250...

  10. 76 FR 68803 - Escalate Capital Partners SBIC I, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

    Science.gov (United States)

    2011-11-07

    ... Courtyard Drive, Suite 309, Austin, TX 78730. The financing is contemplated to provide working capital and... SMALL BUSINESS ADMINISTRATION [License No. 06/06-0335] Escalate Capital Partners SBIC I, L.P... Notice is hereby given that Escalate Capital Partners, SBIC I, L.P., 300 W. 6th Street, Suite 2250...

  11. Constancy and Variability: Dialogic Literacy Events as Sites for Improvisation in Two 3rd-Grade Classrooms

    Science.gov (United States)

    Jordan, Michelle E.; Santori, Diane

    2015-01-01

    This multisite study investigates dialogic literacy events that revolved around narrative and informational texts in two 3rd-grade classrooms. The authors offer a metaphor of musical improvisation to contemplate dialogic literacy events as part of the repertoire of teaching and learning experiences. In literacy learning, where there is much…

  12. Improvising with Material in the Higher Education Dance Technique Class: Exploration and Ownership

    Science.gov (United States)

    Rimmer, Rachel

    2013-01-01

    In this article the author, Rachel Rimmer, explores how improvisation can facilitate skills that are transferable to other areas of dance practice, enabling different areas of study to complement each other. The experimental forum of improvisation as an alternative method of learning technique is considered, contemplating the value of this…

  13. Teaching Critical Analytical Methods in the Digital Typography Classroom.

    Science.gov (United States)

    Gibson, Michael

    1997-01-01

    Describes a studio project designed to help students (1) utilize the digital environment to organize typography and images that represent the socio-political context their solutions were required to identify; and (2) explore the empirical variables that help readers to access and contemplate the content presented by their text. (PA)

  14. 25 CFR 16.3 - Legal representation in State courts.

    Science.gov (United States)

    2010-04-01

    ... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR PROBATE ESTATES OF INDIANS OF THE FIVE CIVILIZED TRIBES § 16.3 Legal representation in State courts. The statutory duties of the Secretary to... necessary to discharge said duties, with due regard to the complexity of the legal action contemplated, the...

  15. European contract law: The contribution of the Dutch

    NARCIS (Netherlands)

    Hondius, E.H.

    1997-01-01

    This paper will argue that when contemplating the elaboration of a European civil law, Dutch law may have some interesting ideas to offer. From the wealth of thoughts offered by the General Reporter, only one particular thread will be taken up in depth. It is the protection of the weaker contracting

  16. Association of Exercise Stages of Change with Glycemic Control in Individuals with Type 2 Diabetes.

    Science.gov (United States)

    Natarajan, Sundar; Clyburn, Ernest B.; Brown, Ronald T.

    2002-01-01

    Investigated the distribution of diabetic patients' stages of change to follow an exercise regimen, examining whether later stages of change were associated with better glycemic control. Data on participants from a primary care clinic (who were predominantly black, female, and indigent) indicated that over half of were in pre-contemplation,…

  17. Current Status of Undergraduate, Nonprofessional Pharmacology Courses Taught in Colleges of Pharmacy

    Science.gov (United States)

    Gerald, Michael C.

    1976-01-01

    Of the 57 colleges of pharmacy surveyed, 33 are currently offering a total of 44 elective, undergraduate, nonprofessional pharmacology courses, and seven contemplate initiating such courses by 1977. The courses generally cover three areas: social and legal aspects of drug usage and nonprescription consumerism; pharmacology of the drugs of abuse;…

  18. Inflation and Financial Statement Analysis in the International Accounting Classroom

    Science.gov (United States)

    Riordan, Diane A.; Riordan, Michael P.

    2009-01-01

    This article provides an exercise for students to contemplate the effects of inflation during financial statement analysis. Even small amounts of inflation accumulating over time can grow to distort a company's reported financial position and results of operations. The growing economies in emerging markets, the international market for oil, and…

  19. Modelo de Integracion Practica del Componente Educativo en los Planes de Manejo de Emergencia

    Science.gov (United States)

    Martinez Jimenez, Magna M.

    2012-01-01

    Education is a basic human right for all people, according to the Universal Declaration of Human Rights. Article 22 of the Children's' Rights Convention stipulates that the Nations are obligated to guarantee that any child requesting refuge receive appropriate protection, humanitarian assistance and full enjoyment of all the rights contemplated in…

  20. Mindfulness and Compassion in Human Development: Introduction to the Special Section

    Science.gov (United States)

    Roeser, Robert W.; Eccles, Jacquelynne S.

    2015-01-01

    Research on contemplative practices (e.g., mindfulness or compassion training) is growing rapidly in the clinical, health and neuro-sciences, but almost none of this research takes an explicitly developmental life span perspective. At present, we know rather little about the naturalistic development of mindfulness or compassion in children and…

  1. 18 CFR 157.5 - Purpose and intent of rules.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Purpose and intent of rules. 157.5 Section 157.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... the market contemplated by the proposed project and the nature and disposition of such other project...

  2. Peace Works: Classroom Activities for Peacemaking.

    Science.gov (United States)

    Teaching Tolerance, 1993

    1993-01-01

    Classroom activities for examining effects of war and contemplating world peace are derived from the story of Sadako, a Japanese girl who died as a result of atomic bomb radiation. Making paper cranes, as Sadako did, and participating in schoolwide programs are suggested for primary, middle, and upper grades. (SLD)

  3. 77 FR 16895 - Announcement of Competition Under the America COMPETES Reauthorization Act of 2011: Project REACH...

    Science.gov (United States)

    2012-03-22

    ... find shelters in the neighborhood of the JBJ Soul Kitchen, a community restaurant in Monmouth County... not explicitly contemplated on the contest Web site. Selection of the winner is in the sole discretion... random. In the unlikely event that more than two competitors tie and all entrants meet the selection...

  4. The Impact of Political Context on the Questions Asked and Answered: The Evolution of Education Research on Racial Inequality

    Science.gov (United States)

    Wells, Amy Stuart; Roda, Allison

    2016-01-01

    This chapter examines how the larger political context and policies enacted at different points in American history have affected the questions education researchers asked and answered. The authors argue that while education researchers are often quick to consider how their research should shape policy, they are less likely to contemplate the…

  5. "The Anatomy of Our Discontent": From Braining the Mind to Mindfulness for Teachers

    Science.gov (United States)

    Baker, Bernadette M.; Saari, Antti

    2018-01-01

    This paper offers an overview of contemporary inscriptions of mindfulness, their conditions of possibility, and examples of the braining of mind on which contemporary neuro-meets-contemplative turns are dependent. We examine key nineteenth-century events integral to the formation of Biologies Old, in which historic debates over "the death of…

  6. On the Use of Extended TAM to Assess Students' Acceptance and Intent to Use Third-Generation Learning Management Systems

    Science.gov (United States)

    Ros, Salvador; Hernández, Roberto; Caminero, Agustín; Robles, Antonio; Barbero, Isabel; Maciá, Araceli; Holgado, Francisco Pablo

    2015-01-01

    Service-oriented e-learning platforms can be considered as a third generation of learning management systems (LMSs). As opposed to the previous generations, consisting of ad hoc solutions and traditional LMS, this new technology contemplates e-learning systems as services that can be integrated into different learning scenarios. This paper shows…

  7. 48 CFR 922.608-4 - Award pending final determination.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Award pending final determination. 922.608-4 Section 922.608-4 Federal Acquisition Regulations System DEPARTMENT OF ENERGY....608-4 Award pending final determination. (a) Award, as contemplated by FAR 22.608-4, may be made only...

  8. Reconsidering the Boundaries of the Cyberloafing Activity: The Case of a University

    Science.gov (United States)

    Zoghbi-Manrique-de-Lara, Pablo

    2012-01-01

    While many scholars generally conceptualise cyberloafing as just one more type of conventional deviant behaviour at work, others consider this activity to be innocuous or even productive. In either case, cyberloafing is viewed as merely misusing Internet resources, without contemplating its potential online character. The purpose of this study is…

  9. 49 CFR 1150.6 - Financial information.

    Science.gov (United States)

    2010-10-01

    ... exhibit F, an income statement for the latest available calendar year prior to filing the application. (c... costs for each year of such construction (in a short narrative or by chart). (d) A statement of projected net income for 2 years, based upon traffic projections. Where construction is contemplated, the...

  10. 26 CFR 1.1082-6 - Basis of property acquired under section 1081(d) in transactions between corporations of the same...

    Science.gov (United States)

    2010-04-01

    ... were the sole consideration for the property transferred to the corporation issuing such stock or... acquired consists of stock or securities, money, and other property, or any of them, but it is contemplated... to the general rule is provided for in case the property acquired consists of stock or securities...

  11. Audiolingual Method and Behaviorism: From Misunderstanding to Myth

    Science.gov (United States)

    Castagnaro, Peter J.

    2006-01-01

    This article contends that the modern descendant of B. F. Skinner's experimental analysis of behavior, "behavior analysis," and as well his 1957 masterwork "Verbal Behavior," have rarely if ever been seriously contemplated by applied linguists for possible contributions to the field. Rather, a pat literature of dismissal has developed that…

  12. The Formation and Development of the Mindful Campus

    Science.gov (United States)

    DuFon, Margaret A.; Christian, Jennifer

    2013-01-01

    This chapter recounts the development of faculty and student groups whose purposes are to promote mindfulness and contemplative pedagogy on the California State University-Chico campus through work both on the campus and in the greater Chico community. The "Mindful Campus" a student organization formed in 2011, merged with the…

  13. 25 CFR 226.28 - Shutdown, abandonment, and plugging of wells.

    Science.gov (United States)

    2010-04-01

    ... OSAGE RESERVATION LANDS FOR OIL AND GAS MINING Cessation of Operations § 226.28 Shutdown, abandonment... production of oil and/or gas has been demonstrated to the satisfaction of the Superintendent. Lessee shall... the means by which the well bore is to be protected, and the contemplated eventual disposition of the...

  14. Entry-Level Employment Prospects for Women in College-Student Personnel Work.

    Science.gov (United States)

    Kuh, George D.

    1979-01-01

    Women are no longer underrepresented in student personnel preparation programs. However, an increased number of female master's degree graduates are seeking a limited number of entry-level positions. Women (and men) should be made aware of the inherent free-market employment risks when contemplating a career in student personnel work. (Author)

  15. Dancing with Demographers.

    Science.gov (United States)

    Robertson, Heather-Jane

    2000-01-01

    Demographic projections concerning the shortage of teachers in Canada, their pay scale, the feminization of teaching, the gender gap in salaries, and teacher autonomy have often been incorrect, or correct for the wrong reasons. Instead of relying on demographic predictions, teachers should contemplate who they really want to be professionally,…

  16. Anatomy of a Bible Course Curriculum.

    Science.gov (United States)

    Paterson, Frances R. A.

    2003-01-01

    Examines case law on the subject of Bible instruction in the public schools, offers a detailed analysis and critique of the National Council on Bible Curriculum in Public Schools curriculum, and provides suggestions for public schools contemplating adding a course on the Bible to their curricula. (Contains 89 references.) (Author/PKP)

  17. 78 FR 28864 - Prospective Grant of Start-Up Exclusive Evaluation Option License Agreement: In Vitro Diagnostics...

    Science.gov (United States)

    2013-05-16

    ... of new blood vessels) and metastasis (spread of cancer). The co-culture system is designed to mimic... contemplating the grant of a Start-Up Exclusive Evaluation Option License Agreement to Advanced Personalized... Angiogenesis and Metastasis in Three Dimensional Co- Cultures'', filed June 10, 2010 (HHS Ref. No. E-281-2007/1...

  18. The United States Army Medical Department Journal. October-December 2011

    Science.gov (United States)

    2011-12-01

    left side of the shield are the 13 stripes of the American Flag. The green staff is the staff of Asclepius (according to Greek mythology , the first...endures but change. When the Greek philosopher Heraclitus penned that contemplation some 2,500 years ago, he undoubtedly had no concept of its

  19. Status og perspektiver for behandling af de kroniske myeloproliferative neoplasier

    DEFF Research Database (Denmark)

    Ocias, Lukas Frans; Holmström, Morten Orebo; Riley, Caroline Hasselbalch

    2015-01-01

    of these malignancies has focused on lowering their inherent thromboembolic risk but with the discovery of the JAK2-V617F mutation and most recently the calreticulin mutations new therapeutic options such as interferon-alpha, JAK2-inhibitors and statins are being contemplated. This article reviews these new treatment...

  20. Perceptions of Cyberbullying Management within Southern California Independent Middle Schools: A Multiple Case Study

    Science.gov (United States)

    Lyons, Suzanne Shaw

    2013-01-01

    Cyberbullying among students has become a serious issue for school communities, partly due to ubiquitous Internet access, instant messaging, and a myriad of social media websites that provide infinite ways to abuse, threaten, and insult others. In some cases, students have been cyberbullied so brutally that adolescent victims even contemplate or…

  1. 29 CFR 1980.115 - Special circumstances; waiver of rules.

    Science.gov (United States)

    2010-07-01

    ... circumstances not contemplated by the provisions of this part, or for good cause shown, the administrative law judge or the Board on review may, upon application, after three days notice to all parties and interveners, waive any rule or issue any orders that justice or the administration of the Act requires. ...

  2. 77 FR 3239 - U.S. Court of Appeals for the Armed Forces Proposed Rules Changes

    Science.gov (United States)

    2012-01-23

    ... problem posed in Project Outreach cases that are often selected and/or calendared well beyond the date for... the permission of the Clerk. This provision contemplated the use of military message traffic or... of pleadings by military message or facsimile is no longer necessary. [FR Doc. 2012-1187 Filed 1-20...

  3. 75 FR 4996 - Safety Requirements for Operators of Small Passenger-Carrying Commercial Motor Vehicles Used in...

    Science.gov (United States)

    2010-02-01

    ... vehicle for driver inspection is 11 hours [250 working days per year x ((95% no defects x 2 minutes 35... the Safe, Accountable, Flexible, Efficient Transportation Equity Act: A Legacy for Users (SAFETEA-LU... exemptions contemplated by the Conference Report or other legislative history. ``[I]n the absence of a...

  4. Management of Maternofetal Emergency in Shock with Fracture of ...

    African Journals Online (AJOL)

    patients where a pancreatic surgery is being contemplated so as to avert inadvertent pancreatic injury and the attendant risk of postsurgical pancreatic fistula.[1-5] It is thus imperative to be aware of and carefully search for uncommon pancreatic anomalies, such as portal annular pancreas, in patients planned for pancreatic ...

  5. 75 FR 82042 - Office of Inspector General; Privacy Act of 1974; Notification of the Office of Inspector General...

    Science.gov (United States)

    2010-12-29

    ...) Independent Auditor Monitoring Files of the Office of Inspector General (HUD/OIG-4); (5) Auto Audit of the... auditor has been notified that the OIG is contemplating disclosure of its findings to an appropriate State board of accountancy, and the independent auditor has been provided with an opportunity to respond in...

  6. 32 CFR 733.3 - Information and policy on support of dependents.

    Science.gov (United States)

    2010-07-01

    ... adequate and continuous support for their lawful dependents and comply with the terms of separation... the child if physical control is obtained. (6) Adopted children. The natural parents of an adopted... parents. A Navy or Marine Corps member who contemplates the adoption of a child should be aware of the...

  7. Differences in All-Cause Health Care Utilization and Costs in a Type 2 Diabetes Mellitus Population with and Without a History of Cardiovascular Disease.

    Science.gov (United States)

    Mehta, Sandhya; Ghosh, Sabyasachi; Sander, Stephen; Kuti, Effie; Mountford, William K

    2018-03-01

    % longer mean inpatient length of stay (RR = 1.15, 95% CI = 1.06-1.25); and 11% more outpatient visits (RR = 1.11, 95% CI = 1.09-1.13) compared with T2DM adults without a history of CVD. Furthermore, the difference in total PPPM health care cost was found to be 16% ($200) higher in adults with a history of CVD (RR = 1.16, 95% CI = 1.13-1.19). PPPM costs associated with outpatient and ER visits were approximately 21% and 19% higher among adults with a history of CVD, respectively (P costs for inpatient visits were similar between the 2 groups. In addition, a subgroup analysis revealed that adjusted differences in PPPM total cost was larger in the younger age group (56% higher cost in those aged costs remains significantly higher in T2DM patients with a history of CVD compared with patients without a history of CVD even after controlling for significant patient comorbid and demographic characteristics. Also, younger age groups had higher differences in outcomes compared with older age groups. This study underscores the importance of cost-effective interventions that may reduce economic burden in this T2DM population with a history of CVD. This study was funded by Boehringer Ingelheim. At the time of this study, Mehta and Mountford were employed by IQVIA, which received funding from Boehringer Ingelheim to conduct this study. Mountford is employed by Allergan, which has no connection with this study. Ghosh, Sander, and Kuti are employed by Boehringer Ingelheim. Study concept and design were contributed by Mountford, Mehta, and Ghosh, along with Sander and Kuti. Mountford and Mehta collected the data, and data interpretation was performed by all the authors. The manuscript was written by Sander and Kuti, along with the other authors, and revised by Mehta and Gosh, along with the other authors.

  8. 48 CFR 552.236-74 - Working Hours.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Working Hours. 552.236-74... Hours. As prescribed in 536.570-5, insert the following clause: Working Hours (APR 1984) (a) It is contemplated that all work will be performed during the customary working hours of the trades involved unless...

  9. Alves VLS, Feldman LB, organizers. Managers of Health in the Scope of Quality: Acting and Competences, multi-disciplined approach. São Paulo (SP: Martinari; 2011

    Directory of Open Access Journals (Sweden)

    Cláudio José de Souza

    2013-07-01

    Full Text Available The changes of the contemporaneity demanded that the professionals in the area of health, besides contemplating the scope of care, also absorbed the managing area. The authors of the reviewed work reaffirmed that, in these two decades of XXI century, there is a close relation between care and management.

  10. Is registrarship a different experience for women? | Saloojee | South ...

    African Journals Online (AJOL)

    FIfty-nine per cent of female registrars believed that they had been disadvantaged in their careers because of their gender, 28% felt that more was expected of a woman registrar and 22% of the female trainees claimed to have been subjected to sexual harassment. The majority (82%) of women registrars contemplated ...

  11. Do Consumers Expect Companies To Be Socially Responsible? The Impact of Corporate Social Responsibility on Buying Behavior.

    Science.gov (United States)

    Mohr, Lois A.; Webb, Deborah J.; Harris, Katherine E.

    2001-01-01

    Interviews with 48 consumers found that they desired moderate to high levels of corporate social responsibility (CSR). Precontemplators (n=16) did not base purchasing on CSR and contemplators (n=11) only moderately. The action group (n=8) had stronger beliefs about CSR but did not always purchase accordingly. Maintainers (n=9) practiced socially…

  12. Energetic plan of the Putumayo

    International Nuclear Information System (INIS)

    Mundo electrico colombiano

    2001-01-01

    The plan to energize contemplates the arrival from the permanent service of energy to all the municipalities from the high Putumayo until the frontier with the Ecuador and it also registers planning actions and execution of a project of generation taking advantage of the local alternative energy for the Municipality of Port Leguizamo

  13. Search Results | Page 105 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    After 50 years of civil war, Colombians are starting to contemplate a future that holds peace. As negotiations between the Government of Colombia and the Revolutionary Armed Forces of Colombia (FARC) progress, many are looking beyond the signing of an accord at the issues that will be key to its successful ...

  14. A School-Based Suicide Risk Assessment Protocol

    Science.gov (United States)

    Boccio, Dana E.

    2015-01-01

    Suicide remains the third leading cause of death among young people in the United States. Considering that youth who contemplate suicide generally exhibit warning signs before engaging in lethal self-harm, school-based mental health professionals can play a vital role in identifying students who are at risk for suicidal behavior. Nevertheless, the…

  15. 48 CFR 27.202-5 - Solicitation provisions and contract clause.

    Science.gov (United States)

    2010-10-01

    ... pricing data are obtained under 15.403; or (ii) Sealed bid solicitations only if the need for such... the contract. If a fixed-price incentive contract is contemplated, change “price” to “target cost and target profit” wherever it appears in the clause. The clause may be used in cost-reimbursement contracts...

  16. Challenging Gender Inequalities in Education and in Working Life--A Mission Possible?

    Science.gov (United States)

    Brunila, Kristiina; Ylöstalo, Hanna

    2015-01-01

    This article deals with challenging the gender inequalities that exist in education and working life. It contemplates the kinds of discursive power relations that have led to gender equality work in Finland. In today's conditions where equality issues are being harnessed more strongly to serve the aims of economic efficiency and productivity, it…

  17. In Cite

    DEFF Research Database (Denmark)

    Elias, Camelia

    your ego. Awareness of what really matters comes from the contemplation of the futility of words. Before the word there is silence. After the word there is silence. But during the word there is knowledge that can be made crystal clear. This book is about extracting what writing means to a few writers...

  18. Ars Longa, Vita Brevis. The Importance Of Art In Human Life. A Proustian Interpretation Of Honigmann’s Forever

    NARCIS (Netherlands)

    van Noortwijk, A.

    2012-01-01

    This article aims to present an exploration of the theme of art’s power within human life in Heddy Honigmann’s documentary film Forever (2006), which exemplifies her obsession with this topic. The film’s contemplation of art is a self-reflexive one, as it uses the medium of film to explore

  19. Ética e animais: reflexões desde o imperativo da alteridade

    Directory of Open Access Journals (Sweden)

    Souza, Ricardo Timm de

    2007-01-01

    Full Text Available O artigo tem como objetivo propor a viabilidade de uma proposta de ética que contemple os animais não-humanos como "interlocutores" possíveis de um modelo ético mais legal a partir da inspiração da ética da Alteridade de E. Levinas

  20. Star Wars and the State of Our Souls. Special Issue. The Whole Earth Papers, No. 20.

    Science.gov (United States)

    Mische, Patricia M.

    These two essays are intended to make U.S. citizens think about what they are doing, to put contemplation before action when considering the "Star Wars" proposals, i.e., proposals for research, development, and testing of space weapons. It is emphasized that the "Star Wars" proposals offer no real breakthroughs in strengthening…

  1. 48 CFR 52.216-11 - Cost Contract-No Fee.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Cost Contract-No Fee. 52....216-11 Cost Contract—No Fee. As prescribed in 16.307(e), insert the following clause in solicitations and contracts when a cost-reimbursement contract is contemplated that provides no fee and is not a...

  2. Crafting a Teaching Persona

    Science.gov (United States)

    Lang, James M.

    2007-01-01

    In this article, the author contemplates two books dealing with developing a teaching persona. These books are Elaine Showalter's "Teaching Literature" and Jay Parini's "The Art of Teaching". Showalter and Parini present very different perspectives on the issue. Showalter addresses it in a section called "Personae: The Teaching Self," in which she…

  3. The Other Side of Life in Slums | Iwuagwu | Journal of History and ...

    African Journals Online (AJOL)

    In spite of obvious social and infrastructural inadequacies in terms of lack of sufficient housing facilities, good roads, schools etc., there is ample evidence to suggest that a significant number of slum dwellers, may never contemplate life outside the slums. This perhaps not only explains the rising number of slums but also ...

  4. Of What is ‘Acute Cancer’ a Case?

    DEFF Research Database (Denmark)

    Tørring, Marie Louise

    of cancer as an acute condition in Denmark. I will argue, with Ian Hacking, that events which took place in Denmark in the 2000s were shaped by a configuration of four principle vectors to be named objectivity, narrativity, cultural polarity and longevity. In the third part, I contemplate on the general...

  5. You're Distracted. This Professor Can Help

    Science.gov (United States)

    Parry, Marc

    2013-01-01

    The e-mail drill was one of numerous mind-training exercises in a unique class designed to raise students' awareness about how they use their digital tools. Colleges have experimented with short-term social-media blackouts in the past. But Ms. Hill's course, "Information and Contemplation," goes way further. Participants scrutinize their…

  6. Is the Frame Broken? Seeking New Metaphors for Textual Study in English

    Science.gov (United States)

    McKnight, Lucinda

    2015-01-01

    This article draws from a doctoral study of how female teachers design English curriculum around girls' popular culture in a contemporary coeducational secondary setting and focuses on how English teachers contemplate the study of texts in the space of school-based curriculum planning. The article presents an argument for reflexivity around how we…

  7. Nathaniel Merriman's Lecture: “Shakspeare, as Bearing on English ...

    African Journals Online (AJOL)

    article placing the lectures in their local context appeared in Shakespeare in Southern Africa 20 (2008): 25-37, accompanying an annotated edition of the first lecture, “On the Study of Shakspeare”. Internal evidence suggests that the second was not contemplated at the time the first was delivered: Shakespeare and history is ...

  8. Foundationalism in Moral Rules and the Problem of Relativism ...

    African Journals Online (AJOL)

    In this paper we undertake a deep critical analysis of the foundations of moral principles. In it we have established that moral rules guiding human conduct are derivable from either the precepts of some religious belief system, societal norms or from the contemplative dispositions of the individual. The conclusion drawn from ...

  9. Kill rate of mastitis pathogens by a combination of cefalexin and kanamycin.

    Science.gov (United States)

    Maneke, E; Pridmore, A; Goby, L; Lang, I

    2011-01-01

    To assess the bacterial killing rate produced by a combination of cefalexin and kanamycin at two different concentration ratios. Time-kill kinetics of cefalexin and kanamycin, individually and in combination, were determined against one strain each of Escherichia coli, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus dysgalactiae and Streptococcus uberis. The combination was tested using two fixed ratios (cefalexin : kanamycin ratios of 1·25 : 1 and 1 : 2·3) and two concentrations of each ratio. Time-kill curves produced with either ratio were quite similar. Against most bacterial species, higher concentrations produced faster kill. In all cases, the combination of cefalexin and kanamycin showed faster and greater kill at lower antibiotic concentrations than those observed with either drug alone. The combination of cefalexin and kanamycin results in a fast initial killing of major mastitis pathogens at both concentration ratios. The combination of cefalexin and kanamycin achieved rapid bacterial kill at concentrations and ratios that can be achieved in vivo following intramammary infusion of a mastitis treatment. © 2010 Boehringer Ingelheim Vetmedica GmbH. Journal of Applied Microbiology © 2010 The Society for Applied Microbiology.

  10. Development and Evaluation of a Rapid Antigen Detection and Serotyping Lateral Flow Antigen Detection System for Foot-and-Mouth Disease Virus.

    Directory of Open Access Journals (Sweden)

    Kazuki Morioka

    Full Text Available We developed a lateral flow strip using monoclonal antibodies (MAbs which allows for rapid antigen detection and serotyping of foot-and-mouth disease virus (FMDV. This FMDV serotyping strip was able to detect all 7 serotypes and distinguish serotypes O, A, C and Asia1. Its sensitivities ranged from 10(3 to 10(4 of a 50% tissue culture infectious dose of each FMDV stain; this is equal to those of the commercial product Svanodip (Boehringer Ingelheim Svanova, Uppsala, Sweden, which can detect all seven serotypes of FMDV, but does not distinguish them. Our evaluation of the FMDV serotyping strip using a total of 118 clinical samples (vesicular fluids, vesicular epithelial emulsions and oral and/or nasal swabs showed highly sensitive antigen detection and accuracy in serotyping in accordance with ELISA or RT-PCR. To the best of our knowledge, this is the first report on any FMDV serotyping strip that provides both rapid antigen detection and serotyping of FMDV at the same time on one strip without extra devices. This method will be useful in both FMD-free countries and FMD-infected countries, especially where laboratory diagnosis cannot be carried out.

  11. Quality Assurance in Higher Education: Which Pasts to Build On, What Futures to Contemplate?

    Science.gov (United States)

    Singh, Mala

    2010-01-01

    The paper is a reflection on the pasts and futures of quality assurance in higher education. It poses questions about the correlation between the geographical and political spread of quality assurance on the one hand and the resulting educational benefits on the other; about the divergences between critics and practitioners on the likely impacts…

  12. Pre-conception counselling in primary care: Prevalence of risk factors among couples contemplating pregnancy

    NARCIS (Netherlands)

    Pal van der-Bruin, K.M. de; Cessie, S. le; Elsinga, J.; Jong de-Potjer, L.C.; Haeringen, A. van; Knuistingh Neven, A.; Verloove-Vanhorick, S.P.; Assendelft, P.

    2008-01-01

    The outcome of pregnancy can be influenced by several risk factors. Women who are informed about these risks during pre-conception counselling (PCC) have an opportunity to take preventive measures in time. Several studies have shown that high-risk populations have a high prevalence of such risk

  13. Relevance of environmental concerns in contemplating development of fission fusion hybrids: a personal view

    International Nuclear Information System (INIS)

    Holdren, J.

    1974-01-01

    A brief comparison of hybrids to pure fusion systems with respect to timing and economics is given. The relevance of environmental concerns is discussed along with environmental criteria for hybrid designs. (U.S.)

  14. Application of the Transtheoretical Model to Predict Exercise Activities in the Students of Islamic Azad University of Sabzevar

    Directory of Open Access Journals (Sweden)

    M. Mohammadi

    2012-04-01

    Full Text Available Background: Based on report of World Health Organization (WHO, about 60-85% of the world's population fails to complete the recommended amount of physical activity required to induce health benefits. It is necessary to assess health status for designing and programming about exercise activities. In this study the effectiveness of Transtheoretical Model (TTM in predicting exercise activities among the students of Islmaic Azad University of Sabzevar was examined. Methods: In this cross sectional-Correlational study. A random (clustered sample of 234 university students in Islamic Azad university of Sabzevar, participated in the study. A standard instrument was used to measure the variables of interest based on transtheoretical model. Reliability and validity of the questionnaire was examined by a panel of experts and cronbach alpha (N=30, α=0.83-0.95. The data were analyzed by SPSS 16.00 statistical software using Path analysis based regression, t-test and ANOVA and Correlation. Results: According to the results, the average age of students was 22.5±3.8 years. The distribution of the participants according to the stages of change model was as follows: pre-contemplation 36.3%, contemplation 25.6%, preparation, 18.9%, action, 10.5% and maintenance 8.7%.These were significant differences between mean of self efficacy, process of change, decisional balance by sex (p<0.05 and stages of change (p<0.01. Behavioral process of change (β=0.399 and self efficacy (β=0.350 were the most important variables for improving levels of exercise. Conclusion: Because the most students (62% were at precontemplation, contemplation and preparation stages and the results showed that behavioral process of change perceived barriers and self efficacy are the most important predictors for improving levels of exercise. Thus, policies and programs to strengthen these factors to promote exercise activities among students is recommended.

  15. The vehicular natural gas - The new motor era

    International Nuclear Information System (INIS)

    Carta Petrolera

    1998-01-01

    The natural gas is the new proposal of ECOPETROL, it is to replace the use of the gasoline and other self-driven fuels for natural gas, taking advantage of the big reserves which Colombia has; the project contemplates to generalize its use in places different to the Atlantic Coast, place where it operates since 1982

  16. PACIFISM AND THE MILITARY - A PERSPECTIVE

    African Journals Online (AJOL)

    this revival of pacifist influence a threat to West- ern military efforts to .... man sacrifice his life even in a cause in which he did not believe. ... by hospital work, civil defence and coal mining.16. The American .... question of balance; no society can contemplate ..... defence, international security, East-West arms control, and ...

  17. Erotic Language as Dramatic Action in Plays by Lyly and Shakespeare

    Science.gov (United States)

    Knoll, Gillian

    2012-01-01

    This study closely examines the language of desire in the dramatic works of John Lyly and William Shakespeare, and argues that contemplative and analytical speeches about desire function as modes of action in their plays. Erotic speeches do more than express desire in a purely descriptive or perlocutionary capacity distinct from the action of the…

  18. Deep Space Exploration: Will We Be Ready? Infectious Diseases, Microgravity and Other Forces Affecting Health Pose Challenges for Humans Planning to Explore Space

    Science.gov (United States)

    LaRocco, Mark T.; Pierson, Duane L.

    1999-01-01

    In contemplating space travel beyond earth orbits, we humans face significant barriers and major challenges. Although researchers involved in several scientific subdisciplines, including space medicine and space life sciences, may provide insights to help overcome those barriers, their efforts are at an early stage of development, leaving open many questions of potentially major consequence.

  19. National companies : performance, ventures, utility

    International Nuclear Information System (INIS)

    Didier, F.

    1994-01-01

    The author shows how a performing National Company can efficiently contribute, in line with the producing State, to the negotiation with International Companies and the success of large oil ventures contemplated by reserves-short countries. Fully entrepreneurial, the National Company will usefully ''explore'' touchy matters, and bring closer national rationale and petroleum rationale. (Author)

  20. The Situation of Colonial "Other" in V. S. Naipaul's "A House for Mr. Biswas"

    Science.gov (United States)

    Siamardi, Tahereh; Deedari, Reza

    2016-01-01

    The focus of the present study is to demonstrate traces of Homi k. Bhabha's notion of identity in V. S. Naipaul's "A House for Mr. Biswas" (1961). As a prominent postcolonial figure, Bhabha has contemplated over the formation of identity in the colonizing circumstances. He discusses on what happens to the colonizer and the colonized…

  1. Introduction to the Special Section: Toward a Dimensionally Based Taxonomy of Psychopathology

    Science.gov (United States)

    Krueger, Robert F.; Watson, David; Barlow, David H.

    2008-01-01

    Much current psychopathology research is framed by categorical constructs. Limitations of categorical constructs have been articulated, and dimensional constructs are often proposed as viable alternatives to categories of psychopathology. The purpose of this Special Section is to articulate and discuss diverse issues that arise in contemplating dimensional constructs as targets for psychopathology research. PMID:16351372

  2. Who Is the Building Leader?: Commentary on Educational Leadership Preparation Programs for the Future

    Science.gov (United States)

    Mercer, Debbie K.

    2016-01-01

    In this commentary, the Dean of the Kansas State University College of Education states that the job of a school leader is more complex and more demanding than ever before. As institutions of higher education contemplate the question "Who is the Building Leader?," defining the roles and responsibilities of the school building leader is…

  3. Free Fall Misconceptions: Results of a Graph Based Pre-Test of Sophomore Civil Engineering Students

    Science.gov (United States)

    Montecinos, Alicia M.

    2014-01-01

    A partially unusual behaviour was found among 14 sophomore students of civil engineering who took a pre test for a free fall laboratory session, in the context of a general mechanics course. An analysis contemplating mathematics models and physics models consistency was made. In all cases, the students presented evidence favoring a correct free…

  4. AASL at 65: A Reflection on and Affirmation of Enduring Core Values that Sustain Us

    Science.gov (United States)

    Ballard, Susan D.

    2016-01-01

    As the American Association of School Librarians (AASL) celebrates sixty-five years in 2016 as a division of the American Library Association (ALA), it is wholly appropriate to examine the life of the organization contemplating what the future holds for school librarians. It is important to understand the past and abiding certainty and steadfast…

  5. To Ink or Not to Ink: The Meaning of Tattoos among College Students

    Science.gov (United States)

    Dickson, Lynda; Dukes, Richard L.; Smith, Hilary; Strapko, Noel

    2015-01-01

    We examine the process of getting a tattoo and its meaning among 195 tattooed and 257 non-tattooed undergraduates. Most tattooed respondents contemplate getting a tattoo for months, get a professional tattoo, can cover it easily, and like it. Respondents acquire first tattoos to represent important role transitions and as a form of identity and…

  6. Poetics of Justice: Using Art as Action and Analysis in Participatory Action Research

    Science.gov (United States)

    Ayala, Jennifer; Zaal, Mayida

    2016-01-01

    This article explores the use of art as a form of communication and meaning-making in participatory action research (PAR). The authors, researchers and educators, contemplate this concept through a pedagogical lens, and consider the role that visual and performing arts can play in social action. Based on the work of a youth-adult participatory…

  7. 48 CFR 1852.216-84 - Estimated cost and incentive fee.

    Science.gov (United States)

    2010-10-01

    ... Provisions and Clauses 1852.216-84 Estimated cost and incentive fee. As prescribed in 1816.406-70(d), insert the following clause: Estimated Cost and Incentive Fee (OCT 1996) The target cost of this contract is $___. The target fee of this contract is $___. The total target cost and target fee as contemplated by the...

  8. Never Let the Truth Stand in the Way of a Good Story: A Work for Three Voices.

    Science.gov (United States)

    Williams, Bronwyn T.

    2003-01-01

    Describes how the author's habit of fabrications and stories as a 10-year-old became a source for writing fiction. Notes how he pursued journalism as a profession, but was frustrated by its limitations. Considers how as a professional field, composition continues to contemplate and struggle with issues of power and representation in research and…

  9. The Effect of Length of Exposure to CALL Technology on Young Iranian EFL Learners' Grammar Gain

    Science.gov (United States)

    Sadeghi, Karim; Dousti, Masoumeh

    2013-01-01

    In the twenty-first century, integration of technology into education is a force worthy of contemplation. Among all the possible technological tools that can be integrated into EFL classes, computers seem to have achieved a more dominant position. One of the outstanding features of computers is their potential to present educational games and to…

  10. The quality of electric services and maintenance

    International Nuclear Information System (INIS)

    Fernandez-Campa Barcelona, J.M.

    1994-01-01

    It describes the perturbations of the electric grids and their repercussions in the receivers. It is contemplated in the present spanish legislation, in reference to the compensation to the users for maintenance cost and is detected his actual inoperativity for reasons of harmonization of the electric characteristics in the area of E.C. (Author)

  11. Naturalness and wilderness: the dilemma and irony of managing wilderness

    Science.gov (United States)

    Peter B. Landres; Mark W. Brunson; Linda Merigliano; Charisse Sydoriak; Steve Morton

    2000-01-01

    This paper summarizes a dialogue session that focused on two concepts that strongly influence nearly all wilderness management: wildness and naturalness. The origin and value of these concepts are discussed, as well as the dilemma and irony that arises when wilderness managers contemplate manipulating the environment to restore naturalness at the risk of reducing...

  12. The neural mediators of kindness-based meditation: a theoretical model

    Directory of Open Access Journals (Sweden)

    Jennifer Streiffer Mascaro

    2015-02-01

    Full Text Available Although kindness-based contemplative practices are increasingly employed by clinicians and cognitive researchers to enhance prosocial emotions, social cognitive skills, and well-being, and as a tool to understand the basic workings of the social mind, we lack a coherent theoretical model with which to test the mechanisms by which kindness-based meditation may alter the brain and body. Here we link contemplative accounts of compassion and loving-kindness practices with research from social cognitive neuroscience and social psychology to generate predictions about how diverse practices may alter brain structure and function and related aspects of social cognition. Contingent on the nuances of the practice, kindness-based meditation may enhance the neural systems related to faster and more basic perceptual or motor simulation processes, simulation of another’s affective body state, slower and higher-level perspective-taking, modulatory processes such as emotion regulation and self/other discrimination, and combinations thereof. This theoretical model will be discussed alongside best practices for testing such a model and potential implications and applications of future work.

  13. El cambio en las conductas adictivas

    Directory of Open Access Journals (Sweden)

    Luis Iván Mayor S.

    2013-09-01

    Full Text Available Concita el interés de los profesionales de la salud mental el descubrir cómo se modifican los comportamientos desadaptativos, más aún existiendo gente que cambia sin tratamiento. Este artículo explica, a partir de un modelo transteórico de etapas y procesos, cómo cambia la gente. Las investigaciones, cada vez más, corroboran que en la modificación de los comportamientos existen 5 etapas: precontemplación, contemplación, preparación, acción y mantenimiento. Además los sujetos siguen procesos comunes en cada una de estas etapas. Mental health professionals could be interested in finding how inappropriate behavior could be modified, especially when there are people that changes without treatment. This article explains how people change with a transteorical model of stages and processes. Psychological research shows that there are five stages in behavior modification: pre-contemplation, contemplation, preparation, action and maintenance. Besides, subjects have common processes in every stage.

  14. Models of rural disperse electrification by means of renewable energies in Latin America: an alternative proposal based on rural development

    International Nuclear Information System (INIS)

    Fuentes, M.; Fuentes, M.; Alvarez, M.

    2004-01-01

    This paper discusses the overdue change in the processes of rural electrification by means of renewable energies. The actors involve in these processes have failed to contemplate every dimension of this issue: Social, Institutional, Technological, Economical, Financial and Political. We will account for the reason why the concept of sustainability must be closely related to that of local socioeconomic development. Rural electrification must be a vector for social development. It is in this context that it cannot depend exclusively on the market and its actors, but it must be immersed within rural development planning. For this new paradigm to work properly, donor agencies -mainly- should understand the dynamics of socioeconomic development, contemplating the different local characteristics of small rural communities; they should provide genuine financial support within an adequate regulatory framework and active participation should be encouraged, both of the local community and of local enterprises. The sustainability of these initiatives is determined not only by the consideration of the dimensions above but also by the creation of labour possibilities or lack thereof. (authors)

  15. Bang! the complete history of the universe

    CERN Document Server

    May, Brian; Lintott, Chris

    2012-01-01

    Bang! Space, time, matter...the Universe was born 13.7 billion years ago. Infinitely small at first, it expanded more rapidly than anyone can contemplate. Brian May, Patrick Moore and Chris Lintott explain how all this came about, from the moment when time and space came into existence, to the formation of the first stars, galaxies and planets, and to the evolution of human beings able to contemplate our own origins and ultimate destiny. Then on towards that destiny in the infinite future, long after the Earth has been consumed by the Red Giant Sun. The story is told in clear, straight forward terms, in the strict order in which the events happened, and uses no mathematics. "Bang!" is an amazing story and this newly revised text brings it "Bang!" up to date. Is it fiction? The authors hope not, since it is based upon lifetimes work by great scientists such as Albert Einstein, Stephen Hawking and hundreds of other brilliant minds. Enjoy, and let your imagination run riot.

  16. Reliability and validity of the Dutch version of the Readiness to Change Questionnaire.

    Science.gov (United States)

    Defuentes-Merillas, L; Dejong, C A J; Schippers, G M

    2002-01-01

    The aim of the present study was to evaluate the psychometric properties of the Dutch version of the Readiness to Change Questionnaire (RCQ-D). The subjects were 246 excessive drinkers admitted to an addiction treatment centre and 54 offenders convicted of an alcohol-related crime in The Netherlands. The factor structure of the RCQ-D for the two samples combined was found to be consistent with the three-factor structure established for the original RCQ. The reliability of the items for each scale was found to be satisfactory. Allocated stage of change showed significant differences between the different subsamples. As expected, the scale scores for adjacent stages of change showed significantly higher inter-correlations than the scale scores for non-adjacent stages. Additionally, the negatively formulated items from the pre-contemplation scale were reformulated positively and their internal consistency tested among the offender sample. The positively formulated pre-contemplation items showed a higher alpha value than the negatively formulated items. We therefore suggest that the positively formulated items should replace the negatively formulated ones.

  17. Final report, Task 3: possible uses of the Nuclear Fuel Services, Inc. reprocessing plant at West Valley, New York

    International Nuclear Information System (INIS)

    1978-01-01

    The West Valley Plant could readily be used for work on reprocessing of alternative fuels, spiking, coprocessing (including CIVEX), waste solidification, and the recovery of radioactive gases. The plant could be easily modified for any scale between small-scale experimental work to production-scale demonstration, involving virtually any combination of fissile/fertile fuel materials that might be used in the future. The use of this plant for the contemplated experimental work would involve lower capital costs than the use of other facilities at DOE sites, except possibly for spiking of recovered products; the operating costs would be no greater than at other sites. The work on reprocessing of alternative fuels and coprocessing could commence within about one year; on recovery of radioactive gases, in 3 to 5 years; on spiking, in 4 years; and on waste solidification demonstration, in about 5 years. The contemplated work could be begun at this plant at least as early as at Barnwell, although work on spiking of recovered products could probably be started in existing hot cells earlier than at West Valley

  18. Financial remuneration for clinical and behavioral research participation: ethical and practical considerations.

    Science.gov (United States)

    Permuth-Wey, Jennifer; Borenstein, Amy R

    2009-04-01

    Although the practice of providing payment to clinical research participants has been ongoing for more than a century, it remains an ethically controversial topic among members of the research community. The aims of this commentary are to summarize ethical and practical considerations regarding financial remuneration of research participants and to make recommendations for researchers contemplating this practice. A PubMed search was conducted to explore the ethical implications surrounding financial remuneration and review the body of empiric data on this topic. Financial remuneration is perceived to be ethically acceptable by many researchers and research participants and can be helpful in the recruitment process. It is recommended that when investigators are contemplating whether to offer payment to research participants, they should consider the nature of the study and the potential benefits and risks to the participants, institutional or organizational guidelines, and cultural and societal norms specific to the population being studied. Financial remuneration has the ability to serve as a sign of appreciation for the contributions of research participants and a way to facilitate clinical and behavioral research.

  19. Changing beliefs about leisure noise: using health promotion models to investigate young people's engagement with, and attitudes towards, hearing health.

    Science.gov (United States)

    Gilliver, Megan; Beach, Elizabeth Francis; Williams, Warwick

    2015-04-01

    To investigate factors influencing young people's motivation to reduce their leisure noise exposure, and protect their hearing health. Questionnaires were conducted online to investigate young people's hearing health attitudes and behaviour. Items were developed using an integrated health promotion approach. The stage of change model was used to group participants in relation to their engagement with noise reduction behaviour. The health belief model was used to compare each group's perceptions of susceptibility and severity of hearing loss, as well as the benefits and barriers to noise reduction. Results are presented for 1196 young Australians aged between 18 and 35 years. Participants' engagement with noise reduction behaviour was used to assign them to stage of change groupings: Maintenance (11%), Action (28%), Contemplation (14%), or Pre-contemplation (43%). Each group's responses to health belief model items highlighted key differences across the different stages of engagement. Future hearing health promotion may benefit from tailoring intervention activities to best suit the stage of change of individuals. Different information may be useful at each stage to best support and motivate young people to look after their hearing health.

  20. Unification and geometrization of physics in the cosmological context

    International Nuclear Information System (INIS)

    Heller, M.; Watykanskie Obserwatorium Astronomiczne, Vatican

    1991-01-01

    Einstein belived that a good physical theory should posses an ''inner perfection''. Trace the inner perfection of the present gauge theories by contemplating their geometric structures (in terms of fibre bundles). The search for the ultimate symmetry of the unification of physics unavoidably leads to the unification of physics and cosmology. 4 figs., 23 refs. (author)

  1. County Library Service to Rural Schools. Bulletin, 1930, No. 20

    Science.gov (United States)

    Lathrop, Edith A.

    1930-01-01

    An efficient county library contemplates maximum service for money expended. Situated at the county seat or at some other centrally located place within the county, its book stock is carried to every resident of the county through a system branches, stations, and school deposits, and the services of an automobile and the parcel post. A trained…

  2. UNE SYNTHÈSE CULTURELLE DANS L'OEUVRE DE MIRCEA ELIADE

    Directory of Open Access Journals (Sweden)

    Dr. Libuše VALENTOVÁ

    2011-05-01

    Full Text Available Mircea Eliade's vast and complex work represents a synthesis of multicultural features defined through the close connection between the elements of a whole series of polarities: modernity/tradition, rationalism/contemplation, critical/religious spirit etc. and, at the same time, as a dialogue grafted onto the experience of the closeness between Occidental and Oriental culture.

  3. Inking and Thinking: Honors Students and Tattoos

    Science.gov (United States)

    Dundes, Lauren; Francis, Antonia

    2016-01-01

    This study examines whether academically accelerated students in a college Honors program are as likely as other students to acquire a tattoo and to spend the same amount of time contemplating this decision. A convenience sample of 71 honors students and 135 non-honors students completed a survey at a small mid-Atlantic liberal arts college in…

  4. Media Ethics: Some Specific Problems. ERIC Digest.

    Science.gov (United States)

    Gottlieb, Stephen S.

    This digest identifies some of the ethical issues which appeared in the mass media in the 1980s and discusses the implications which these issues have for the law and for those who already work in or study the mass media, as well as for those college students contemplating a career in journalism or broadcasting. (NKA)

  5. Democracy, Freedom, and Justice after September 11th: Rethinking the Role of Educators and the Politics of Schooling.

    Science.gov (United States)

    Giroux, Henry A.

    2002-01-01

    Illustrates how life in post-September 11 America is both a rupture from certain anti-government politics that dominated before that day and a continuation of the pre-September 11 promotion of global capitalism and the abandonment of efforts to create greater equality. The paper attempts to help educators contemplate the role of public schools in…

  6. Tim Allen, one of Hollywood's top comedy actors with Rolf Landua from CERN

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    Tim Allen ('Galaxy Quest', 'For Richer and Poorer', 'The Santa Clause', Voice of 'Buzz Lightyear', in Toy Story 1 and 2), visited CERN in July 2000. He has a keen interest in modern physics. In his last book "I'm not really here" he contemplates the funny and the intriguing aspects of quantum physics in his daily life.

  7. The Killing of the Workers' Educational Association of Victoria: A Myth Challenged

    Science.gov (United States)

    Dadswell, Gordon

    2004-01-01

    On 21 March 1941, the Council of the Workers' Educational Association of Victoria, Australia, (the Association) voted the organisation out of existence. The demise was in no way contemplated, and there was no practical reason why the Council acted in the way it did. This paper is the story of the destruction of a successful adult education…

  8. 26 CFR 31.3401(a)(15)-1 - Moving expenses.

    Science.gov (United States)

    2010-04-01

    ...) EMPLOYMENT TAXES AND COLLECTION OF INCOME TAX AT SOURCE EMPLOYMENT TAXES AND COLLECTION OF INCOME TAX AT SOURCE Collection of Income Tax at Source § 31.3401(a)(15)-1 Moving expenses. (a) An amount paid to or on... contemplated by the statute may be based upon any evidence reasonably sufficient to induce such belief, even...

  9. 28 CFR 73.1 - Definition of terms.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Definition of terms. 73.1 Section 73.1... OF FOREIGN GOVERNMENTS § 73.1 Definition of terms. (a) The term agent means all individuals acting as... facsimile must be received by the addressee named in § 73.3 prior to commencing the services contemplated by...

  10. Só em direção ao só: considerações sobre a mística de Plotino

    Directory of Open Access Journals (Sweden)

    Bernardo Guadalupe dos Santos Lins Brandão

    2009-05-01

    Full Text Available Resumo Plotino é um pensador estranho para o filósofo contemporâneo: nas suas Enéadas, ele discute experiência mística e prática filosófica como se fosse uma mesma coisa. De fato, no pensamento plotiniano, o ápice da vida filosófica é a contemplação mística: não pensamento irracional, mas uma forma supra-racional de consciência que é alcançada pela prática ascética e pelo procedimento dialético. Este artigo tenta entender o que é a experiência mística em Plotino. Na verdade, uma leitura atenta dos textos das Enéadas que tratam do assunto mostram que não existe apenas um, mas dois tipos de contemplação mística supra-racional: a experiência da alma humana unida ao Intelecto divino e a experiência da alma humana unida ao Um, o princípio supremo da realidade de acordo com a filosofia plotiniana. Ambos são tipos de intuição intelectual interior, mas, se a experiência mística do Intelecto é a contemplação da totalidade do mundo inteligível, a contemplação do Um é a intuição da identidade pura, além de toda a diferença. Palavras-chave: Plotino; Neoplatonismo; Mística. Abstract Plotinus is a strange scholar to the contemporary philosopher: in his Enneads, he discusses mystical experience and philosophical practice as if they were the same thing. Indeed, according to his thoughts, the summit of philosophical life is mystical contemplation: not irrational thinking, but a supra-rational form of consciousness achieved through ascetic practice and dialectical procedure. This paper attempts to understand the mystical experience in Plotinus. In fact, a close reading of the texts of the Enneads on the subject demonstrates that there are not only one, but two kinds of supra-rational mystical contemplation: the experience of the human soul united to the divine Intellect and the experience of the human soul united to the One, the supreme principle of reality according to Plotinus's philosophy. Both are kinds of

  11. La Geomorfología moderna y su importancia en los estudios del relieve mexicano

    OpenAIRE

    José Lugo Hubp

    1982-01-01

    We contemplate some historic antecedents of the geomorphology, it´s foundation to the end of the past era, and it´s actual evolution. From the short analysis in the regional plan, about Mexican Republic topography, we conduce wich are the fundamentals geomorphology problems of economic interests, and way the remising of the geographical cycle theory of Davis in the Mexican territory.

  12. Better marking means cheaper pruning.

    Science.gov (United States)

    Kenneth R. Eversole

    1953-01-01

    Careful selection of trees to be pruned can make the difference between profit and loss on the pruning investment, especially in stands where no thinning is contemplated. Expert marking is required to make sure that the pruned trees will grow rapidly. The most important variable influencing the cost of clear wood produced by pruning is growth rate. For example, at 3...

  13. Associations between poor sleep quality and stages of change of multiple health behaviors among participants of employee wellness program

    Directory of Open Access Journals (Sweden)

    Siu-kuen Azor Hui

    2015-01-01

    Conclusions: The present study demonstrated that poor sleep quality was associated with an elevated likelihood of contemplating or initiating behavior change, but a decreased likelihood of maintaining healthy behavior change. It is important to include sleep improvement as one of the lifestyle management interventions offered in EWP to comprehensively reduce health risks and promote the health of a large employee population.

  14. 26 CFR 1.682(a)-1 - Income of trust in case of divorce, etc.

    Science.gov (United States)

    2010-04-01

    ... and not in contemplation of it, while section 71 applies only if the creation of the trust or payments... fix in terms of an amount of money or a portion of the income as a sum which is payable for the... terms of an amount of money is to be paid but a lesser amount becomes payable, the trust income is...

  15. The People Who Were Here Before Speak to the People Here Now.

    Science.gov (United States)

    Garvey, James W.

    The value of hearing, contemplating, and remembering the ancient tales of the Seneca Indians of upstate New York is the theme of this paper. Three of the legends, the Storytelling Stone, the Woman Who Fell from the Sky, and Naked Bear, are related by the author. They are considered for their mythic concerns and in terms of their value and relation…

  16. Head Start at Ages 3 and 4 versus Head Start Followed by State Pre-K: Which Is More Effective?

    Science.gov (United States)

    Jenkins, Jade Marcus; Farkas, George; Duncan, Greg J.; Burchinal, Margaret; Vandell, Deborah Lowe

    2016-01-01

    As policy-makers contemplate expanding preschool opportunities for low-income children, one possibility is to fund two, rather than one year of Head Start for children at ages 3 and 4. Another option is to offer one year of Head Start followed by one year of pre-k. We ask which of these options is more effective. We use data from the Oklahoma…

  17. Visitors' Characteristics, Preferences and Perception of the Impacts of Public Use at Salto Morato Natural Reserve

    Science.gov (United States)

    Leide Y. Takahashi; Miguel S. Milano

    2004-01-01

    Visiting wild areas as motivated by man’s desire to be in close contact with nature and to contemplate its beauty is an old recreational practice, done through activities such as hiking, hunting and picnicking. With post-war economic changes and technological innovations in multiple fields, there has been a significant increase in spare time, leading to a corresponding...

  18. Africa in the imaginary: the geographical explorations of the king Juba II of Mauretania

    Directory of Open Access Journals (Sweden)

    Enrique GOZALBES CRAVIOTO

    2012-03-01

    Full Text Available In the present study we analyzed the different texts of the Latin encyclopaedist Plinio, specially the texts that refer to the geographical explorations of the king Juba II of Mauretania. These explorations developed from two directions, the Atlantic Africa and the mountain chain of the Atlas. Juba II contemplated both cases from the own image inherited from the African continent.

  19. Planning a Library Leadership Retreat on the Cheap: Case Study and Analysis

    Science.gov (United States)

    Brower, Stewart

    2016-01-01

    Staying ahead of the pitch: an old baseball metaphor that means to anticipate where the ball is going to go so that the batter can score a hit. But to anticipate changes in a field as robust and challenging as information sciences, reflection and contemplation are often key to good planning. With simple day-to-day management of libraries already…

  20. We'll Paint the Octopus Red.

    Science.gov (United States)

    Stuve-Bodeen, Stephanie

    This children's book tells the story of a little girl who has a new baby brother with Down syndrome. Her contemplation of the advantages and disadvantages of having a sibling is highlighted. When she finds out the baby has Down syndrome, her initial reaction is that the baby won't be able to do all the wonderful things she has thought they would…