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Sample records for ing dr techn

  1. Dr Oen Boen Ing Patriot doctor, social activist, and doctor of the poor

    Directory of Open Access Journals (Sweden)

    Ravando Lie

    2017-05-01

    Full Text Available This article examines the efforts and achievements of Oen Boen Ing, a Tionghoa doctor, to improve the quality of health of the poorer inhabitants of Surakarta. Dr Oen played an important role in five different periods: Dutch colonialism, the Japanese occupation, the Indonesian revolution, Soekarno’s regime, and Suharto’s New Order. Known for being a benevolent doctor, activist, and patriot of the revolution during his life-time, Dr Oen also gave medical assistance to the needy, which famously earned him the accolade of “doctor of the poor”. During the Indonesian revolution, Dr Oen assisted the Student Soldiers (Tentara Pelajar and afterwards was appointed the member of Supreme Advisory Council (Dewan Pertimbangan Agung/DPA by Soekarno in 1949. As a benevolent doctor and activist, Dr Oen is remembered for founding the Panti Kosala Hospital which was renamed to perpetuate his name on 30 October 1983, exactly a year after his passing. When he died, thousands of peoples gathered to pay their final respects to the doctor. He was honoured with a ceremony conducted in the Mangkunegaran Palace. Dr Oen’s name will be eternally respected, especially in Surakarta.

  2. "Techne" and Technical Communication: Toward a Dialogue.

    Science.gov (United States)

    Gordon, Jay

    2002-01-01

    Offers background on how the term "techne" was used up through the fourth century BCE. Discusses how modern discourse on technical communication both converges with and departs from Plato's and Aristotle's statements on the relationship between "techne" and rhetoric. Points out areas for further discussion as teachers of…

  3. 2012 annual meeting on nuclear technology. Workshop on 'Preservation of competence in nuclear technology'

    International Nuclear Information System (INIS)

    Steinwarz, Wolfgang

    2012-01-01

    Within the 2-day workshop on 'Preservation of Competence in Nuclear Technology,' 31 young scientists competed for the 'Competence Prize' awarded by Siempelkamp Nukleartechnik for the 14th time. They reported about their papers focusing on nuclear technology, reactor technology, innovative reactor systems, radioactive waste management, radiological protection and energy supply systems. The jury composed of Prof. J. Starflinger (Universitaet Stuttgart, IKE), Prof. M.K. Koch (Ruhr-Universitaet Bochum, LEE), and Dr. W. Steinwarz (Siempelkamp Nukleartechnik) assessed the advance compacts as well as the oral presentations. The winner of the 2012 Competence Prize is Dipl.-Ing.(M.S.) Thomas M. Fesich (University Stuttgart). Dr.-Ing. Oliver Czaikowski (Techn. University Clausthal) and Dipl.-Ing. Mario Kuschewski (Universitaet Stuttgart) won the second and third prizes. (orig.)

  4. The Role of Techne in the Authenticity-Inauthenticity Distinction

    Directory of Open Access Journals (Sweden)

    Kristina Lebedeva

    2007-12-01

    Full Text Available In this paper I propose to do the following: I will discuss the notions of intentionality and self-understanding of Dasein as developed in Heidegger's Basic Problems of Phenomenology. In doing so, I will try to show the interrelation of Dasein's always being intentionally directed towards something and its self-interpretation. As we will see, the everyday world has, for Heidegger, a character of "equipmental contexture." This means that Dasein returns to itself from out of things, equipment, tools, or - quite differently - the work of art. In a word, Dasein is mirrored back toward itself from the things made, from the products of techne. From this will follow the important distinction between authenticity and inauthenticity. There is a sense in which the following pairings could be discerned: tools or pieces of equipment link up with inauthenticity, while the work of art links up with authenticity. I will say more on the subject of tools a bit later in the essay. Both kinds of things are things insofar as they are entrenched in techne. The common root seems almost inexplicable in the light of the vast difference between tools and the artwork. Moreover, both Dasein and techne seem to have another equally enigmatic common root: that of temporality. Temporality is the essential bond between Dasein and the double sense of techne, which suggests the double-sidedness of temporality itself. It is precisely this doublesidedness that I would like to have as the backdrop to my discussion as a whole. Finally, I will turn to a few pages of Heidegger's Being and Time and Bernard Stiegler's book Technics and Time I in order to complicate this notion of the two senses of temporality, the owned and disowned, originary and everyday, and its relation to work and techne. The overarching question here will be: Can the distinction between authenticity and inauthenticity be sustained?

  5. Centenary of the birth of Bernhard Sann - the founder of modern mining research; Bernhard Sann - dem Begruender der modernen Bergbauforschung zum 100. Geburtstag

    Energy Technology Data Exchange (ETDEWEB)

    Scherschel, Manfred; Pasche, Eckart

    2010-05-15

    When Bernhard Sann was offered a position at the RWTH Aachen in 1961 not only was the Institute for Mining Science II - mechanical extraction technology and mining equipment - established, but the foundation stone was also laid for modern mining research. On the occasion of the centenary of the birth of its first director, Professor Dr.-Ing. Dr. Mont. Dr. techn. Dr. E.h. Bernhard Sann, some lifetime achievements of this natural scientist will be remembered on 16 June. As a teacher he warned of the need to cultivate the basic subjects and as a researcher he endeavoured to implement the results of his investigations in practice, be it in extraction and ventilation technology in the mining industry or in the aircraft industry. (orig.)

  6. Grow-ING, Age-ING and Die-ING: ING proteins link cancer, senescence and apoptosis

    International Nuclear Information System (INIS)

    Russell, Michael; Berardi, Philip; Gong Wei; Riabowol, Karl

    2006-01-01

    The INhibitor of Growth (ING) family of plant homeodomain (PHD) proteins induce apoptosis and regulate gene expression through stress-inducible binding of phospholipids with subsequent nuclear and nucleolar localization. Relocalization occurs concomitantly with interaction with a subset of nuclear proteins, including PCNA, p53 and several regulators of acetylation such as the p300/CBP and PCAF histone acetyltransferases (HATs), as well as the histone deacetylases HDAC1 and hSir2. These interactions alter the localized state of chromatin compaction, subsequently affecting the expression of subsets of genes, including those associated with the stress response (Hsp70), apoptosis (Bax, MDM2) and cell cycle regulation (p21 WAF1 , cyclin B) in a cell- and tissue-specific manner. The expression levels and subcellular localization of ING proteins are altered in a significant number of human cancer types, while the expression of ING isoforms changes during cellular aging, suggesting that ING proteins may play a role in linking cellular transformation and replicative senescence. The variety of functions attributed to ING proteins suggest that this tumor suppressor serves to link the disparate processes of cell cycle regulation, cell suicide and cellular aging through epigenetic regulation of gene expression. This review examines recent findings in the ING field with a focus on the functions of protein-protein interactions involving ING family members and the mechanisms by which these interactions facilitate the various roles that ING proteins play in tumorigenesis, apoptosis and senescence

  7. 34{sup th} international Vienna motor symposium. Vol. 2. Second day; 34. Internationales Wiener Motorensymposium. Bd. 2. Zweiter Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, Hans Peter (comp.)

    2013-08-01

    This two-volume report makes the presentations of the 34th International Vienna Motor Symposium (April 25-26, 2013) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest. Among others, the work examines the above mentioned topics. Included is a CD-ROM containing the presentations in their original form and in English translation. Edited by Univ.-Prof. Dr. techn. Dipl.-Ing. H. P. Lenz, VDI, Chairman of the OeVK (Austrian Society of Automotive Engineers, Vienna).

  8. 34{sup th} international Vienna motor symposium. Vol. 1. First day; 34. Internationales Wiener Motorensymposium. Bd. 1. Erster Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, Hans Peter (comp.)

    2013-08-01

    This two-volume report makes the presentations of the 34th International Vienna Motor Symposium (April 25-26, 2013) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest. Among others, the work examines the above mentioned topics. Included is a CD-ROM containing the presentations in their original form and in English translation. Edited by Univ.-Prof. Dr. techn. Dipl.-Ing. H. P. Lenz, VDI, Chairman of the OeVK (Austrian Society of Automotive Engineers, Vienna).

  9. 18 Technè, Dianoia and Mythos: Heirlooms to Comparative Study of ...

    African Journals Online (AJOL)

    Ngozi Ezenwa-Ohaeto

    its own unarmed for signification as “free speech, speech unburdened of its ... format through characters' actions. As a twin ... them into being, the creative act, techné; and the only ..... because of his sympathy toward man, figures. Unlike.

  10. 33{sup rd} international Vienna motor symposium. Vol. 2. Second day; 33. internationales Wiener Motorensymposium. Bd. 2. Zweiter Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, Hans Peter (comp.)

    2012-11-01

    This two-volume report makes the presentations of the 33{sup rd} International Vienna Motor Symposium (April 26-27, 2012) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest. Among others, the work examines the above mentioned topics. Included is a CD-ROM containing the presentations in their original form and in English translation. Edited by Univ.-Prof. Dr. techn. Dipl.-Ing. H.P. Lenz, VDI, Chairman of the OeVK (Austrian Society of Automotive Engineers, Vienna).

  11. 33{sup rd} international Vienna motor symposium. Vol. 1. First day; 33. internationales Wiener Motorensymposium. Bd. 1. Erster Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, Hans Peter (comp.)

    2012-11-01

    This two-volume report makes the presentations of the 33{sup rd} International Vienna Motor Symposium (April 26-27, 2012) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest. Among others, the work examines the above mentioned topics. Included is a CD-ROM containing the presentations in their original form and in English translation. Edited by Univ.-Prof. Dr. techn. Dipl.-Ing. H.P. Lenz, VDI, Chairman of the OeVK (Austrian Society of Automotive Engineers, Vienna).

  12. Technē/Technology : Researching Cinema and Media Technologies - Their Development, Use, and Impact

    NARCIS (Netherlands)

    van den Oever, Annie

    2014-01-01

    Technē/Technology is the up-to-date critical volume on the theories, philosophies, and debates on technology and their productivity for the fields of film and media studies. Comprehensive as well as innovative, it is not organised around a single thesis - except the assertion that technique is a

  13. Ingénierie didactique

    OpenAIRE

    Marty , Olivier

    2015-01-01

    Leçon 1 : introduction théoriqueLeçon 2 : concepts fondamentaux de l’ingénierie didactiqueLeçon 3 : construire une ingénierie pédagogiqueLa didactique professionnelle : autour d’un cas pratiqueLeçon 4 : gestion de l’ingénierie de formation; Master; Cours d'ingénierie didactique. Intervention du premier semestre 2015 dans le master Ingénierie de formation de l'université de Lille.Support progressivement mis à disposition des étudiants dans la plateforme d'enseignement à distance Accel (puis co...

  14. RegulatING chromatin regulators

    DEFF Research Database (Denmark)

    Satpathy, Shankha; Nabbi, Arash; Riabowol, Karl

    2013-01-01

    The five human ING genes encode at least 15 splicing isoforms, most of which affect cell growth, differentiation and apoptosis through their ability to alter gene expression by epigenetic mechanisms. Since their discovery in 1996, ING proteins have been classified as type II tumour suppressors on...

  15. Projet TECHNE : vers un apprentissage collaboratif dans une classe virtuelle bilingue TECHNE Project: Towards collaborative learning in bilingual virtual classrooms

    Directory of Open Access Journals (Sweden)

    Roisin Donohoe

    2000-06-01

    Full Text Available La Communication Médiatisée par Ordinateur (CMO permet l’élargissement des frontières temporelles et spatiales de la salle de classe. Son exploitation pédagogique a donné naissance à de nombreux projets d’apprentissage des langues étrangères dont les fondements théoriques trouvent leurs origines dans les théories socioculturelles de l’apprentissage. La théorie de l’activité (TA, issue des travaux inspirés par Vygotsky, nous permet quant à elle de mieux appréhender le rôle de médiation que les outils et artefacts jouent dans un apprentissage collaboratif tout en fournissant un cadre de référence facilitant la description des processus en jeu au cours d’un tel apprentissage. TECHNE, projet de recherche-action conçu pour promouvoir un apprentissage collaboratif au sein de classes virtuelles et bilingues, s’inscrit dans une telle perspective. Après une description du projet, nous nous attachons à examiner certains des processus de collaboration en ligne que nous avons pu observer. Les résultats préliminaires d’une analyse quantitative des échanges effectués en ligne précèdent une étude qualitative d’échanges étalés sur plusieurs jours ou plusieurs heures. Nous formulons alors des axes de recherche future visant à mieux intégrer apprentissage de la langue et développement de compétences interculturelles et transversales.Computer Mediated Communication (CMC opens up the frontiers of the classroom. The use of CMC as a pedagogical tool has led to the creation of a number of language learning projects which call on the socio-cultural theories of learning. Activity Theory, originating from Vygotsky’s work, can help us to understand the mediation role of tools and artefacts in a collaborative learning environment while, at the same time supplying a framework for the description of the factors which come into play within such an environment. TECHNE, which was designed to promote collaborative learning

  16. Experimental and numerical investigations of radiation characteristics of Russian portable/compact pulsed neutron generators: ING-031, ING-07, ING-06 and ING-10-20-120

    International Nuclear Information System (INIS)

    Chernikova, D.; Romodanov, V.L.; Belevitin, A.G.; Afanas'ev, V.V.; Sakharov, V.K.; Bogolubov, E.P.; Ryzhkov, V.I.; Khasaev, T.O.; Sladkov, A.A.; Bitulev, A.A.

    2014-01-01

    The present paper discusses results of full-scale experimental and numerical investigations of influence of construction materials of portable pulsed neutron generators ING-031, ING-07, ING-06 and ING-10-20-120 (VNIIA, Russia) to their radiation characteristics formed during and after an operation (shutdown period). In particular, it is shown that an original monoenergetic isotropic angular distribution of neutrons emitted by TiT target changes into the significantly anisotropic angular distribution with a broad energy spectrum stretching to the thermal region. Along with the low-energetic neutron part, a significant amount of photons appears during the operation of generators. In the pulse mode of operation of neutron generator, a presence of the construction materials leads to the “tailing” of the original neutron pulse and the appearance of an accompanying photon pulse at ∼3ns after the instant neutron pulse. In addition to that, reactions of neutron capture and inelastic scattering lead to the creation of radioactive nuclides, such as 58 Co, 62 Cu, 64 Cu and 18 F, which form the so-called activation radiation. Thus, the selection of a portable neutron generator for a particular type of application has to be done considering radiation characteristics of the generator itself. This paper will be of interest to users of neutron generators, providing them with valuable information about limitations of a specific generator and with recommendations for improving the design and performance of the generator as a whole

  17. Crystal structure of inhibitor of growth 4 (ING4) dimerization domain reveals functional organization of ING family of chromatin-binding proteins.

    Science.gov (United States)

    Culurgioni, Simone; Muñoz, Inés G; Moreno, Alberto; Palacios, Alicia; Villate, Maider; Palmero, Ignacio; Montoya, Guillermo; Blanco, Francisco J

    2012-03-30

    The protein ING4 binds to histone H3 trimethylated at Lys-4 (H3K4me3) through its C-terminal plant homeodomain, thus recruiting the HBO1 histone acetyltransferase complex to target promoters. The structure of the plant homeodomain finger bound to an H3K4me3 peptide has been described, as well as the disorder and flexibility in the ING4 central region. We report the crystal structure of the ING4 N-terminal domain, which shows an antiparallel coiled-coil homodimer with each protomer folded into a helix-loop-helix structure. This arrangement suggests that ING4 can bind simultaneously two histone tails on the same or different nucleosomes. Dimerization has a direct impact on ING4 tumor suppressor activity because monomeric mutants lose the ability to induce apoptosis after genotoxic stress. Homology modeling based on the ING4 structure suggests that other ING dimers may also exist.

  18. The tumor suppressors p33ING1 and p33ING2 interact with alien in vivo and enhance alien-mediated gene silencing.

    Science.gov (United States)

    Fegers, Inga; Kob, Robert; Eckey, Maren; Schmidt, Oliver; Goeman, Frauke; Papaioannou, Maria; Escher, Niko; von Eggeling, Ferdinand; Melle, Christian; Baniahmad, Aria

    2007-11-01

    The tumor suppressor p33ING1 is involved in DNA repair and cell cycle regulation. Furthermore, p33ING1 is a transcriptional silencer that recognizes the histone mark for trimethylated lysine 4 at histone H3. Interestingly, expression of p33ING1 and p33ING2 is able to induce premature senescence in primary human fibroblasts. The corepressor Alien is involved in gene silencing mediated by selected members of nuclear hormone receptors. In addition, Alien acts as a corepressor for E2F1, a member of the E2F cell cycle regulatory family. Furthermore, recent findings suggest that Alien is complexed with transcription factors participating in DNA repair and chromatin. Here, using a proteomic approach by surface-enhanced laser desorption ionization and mass spectrometry (SELDI-MS) combined with immunological techniques, we show that Alien interacts in vivo with the tumor suppressor p33ING1 as well as with the related tumor suppressor candidate p33ING2. The interaction of Alien with p33ING1 and p33ING2 was confirmed in vitro with GST-pull-down, suggesting a direct binding of Alien to these factors. The binding domain was mapped to a central region of Alien. Functionally, the expression of p33ING1 or p33ING2 enhances the Alien-mediated silencing, suggesting that the interaction plays a role in transcriptional regulation. Thus, the findings suggest that the identified interaction between Alien and the tumor suppressors p33ING1 and p33ING2 reveals a novel cellular protein network.

  19. ING1 induces apoptosis through direct effects at the mitochondria

    DEFF Research Database (Denmark)

    Bose, P; Thakur, S; Thalappilly, S

    2013-01-01

    The ING family of tumor suppressors acts as readers and writers of the histone epigenetic code, affecting DNA repair, chromatin remodeling, cellular senescence, cell cycle regulation and apoptosis. The best characterized member of the ING family, ING1,interacts with the proliferating cell nuclear....... Bioinformatic analysis of the yeast interactome indicates that yeast ING proteins interact with 64 mitochondrial proteins. Also, sequence analysis of ING1 reveals the presence of a BH3-like domain. These data suggest a model in which stress-induced cytoplasmic relocalization of ING1 by14-3-3 induces ING1-BAX...

  20. SUMOylation of the ING1b tumor suppressor regulates gene transcription

    DEFF Research Database (Denmark)

    Satpathy, Shankha; Guérillon, Claire; Kim, Tae-Sun

    2014-01-01

    members of histone deacetylase complexes, whereas ING3-5 are stoichiometric components of different histone acetyltransferase complexes. The INGs target these complexes to histone marks, thus acting as epigenetic regulators. ING proteins affect angiogenesis, apoptosis, DNA repair, metastasis......1b E195A), we further demonstrate that ING1b SUMOylation regulates the binding of ING1b to the ISG15 and DGCR8 promoters, consequently regulating ISG15 and DGCR8 transcription. These results suggest a role for ING1b SUMOylation in the regulation of gene transcription....

  1. Engineering challenges in ING

    International Nuclear Information System (INIS)

    Wolfe, W.A.

    1965-01-01

    With the Intense Neutron Generator (ING) we intend to produce a neutron flux of 10 16 n/cm 2 sec. Bismuth, bombarded by 1 GeV protons, yields about 20 neutrons per proton with a heat output of 23 MeV/neutron. A circulating liquid bismuth target will dissipate about 34 MW of heat. To produce the beam we will accelerate protons in a separated orbit cyclotron. The 65 mA current will require about 70-75 MW of radio-frequency power (50-200 Mc/s). We must generate and transmit RF efficiently. In ING precise magnet-fields, resonating-cavity electric-fields and well maintained vacuum (10 -6 torr) will place demands on most of today's engineering technology. (author)

  2. Education of Coexistence as Technē Tou Biou

    Directory of Open Access Journals (Sweden)

    Tomas Kačerauskas

    2011-02-01

    Full Text Available The article deals with education of coexistence as training of life art (technē tou biou. The major thesis is the following: our existence has been educated in the life environment together with other agents of life world (Lebenswelt, while the latter are educated in the background of our existential project to be realized during our life. This major thesis presupposes the minor ones developed in the article: existential education means the change of the roles between the agents of life enwironment; existential education covers an ironic relationship between the teacher and a disciple; the teacher educates an unique combination of the disciple’s charachteristics to be nourished in his (her existential perspective instead of forcing the equal way for everybody; every community has been educated while an individual changes life environment by realization of his (her existential utopia; education is a kind of existential tradition’s transfer through the new communicative channels; philosophy of education based on existential phenomenology stresses the aspects of responsible coexistence in the life-world to be created; education is the training of our life’s art as responsible creation inseparable from becoming of life-world as the environment of our coexistence; education deals with a miracle of breaking educational circle while a disciple excels the teacher and changes the educational environment. By analysing the problems of existential education the author uses the approaches of both existential phenomenology and cultural regionalistics. 

  3. Model(ing) Law

    DEFF Research Database (Denmark)

    Carlson, Kerstin

    The International Criminal Tribunal for the former Yugoslavia (ICTY) was the first and most celebrated of a wave of international criminal tribunals (ICTs) built in the 1990s designed to advance liberalism through international criminal law. Model(ing) Justice examines the case law of the ICTY...

  4. ING3 promotes prostate cancer growth by activating the androgen receptor.

    Science.gov (United States)

    Nabbi, Arash; McClurg, Urszula L; Thalappilly, Subhash; Almami, Amal; Mobahat, Mahsa; Bismar, Tarek A; Binda, Olivier; Riabowol, Karl T

    2017-05-16

    The androgen receptor (AR) is a major driver of prostate cancer, and increased AR levels and co-activators of the receptor promote the development of prostate cancer. INhibitor of Growth (ING) proteins target lysine acetyltransferase or lysine deacetylase complexes to the histone H3K4Me3 mark of active transcription, to affect chromatin structure and gene expression. ING3 is a stoichiometric member of the TIP60 lysine acetyltransferase complex implicated in prostate cancer development. Biopsies of 265 patients with prostate cancer were stained for ING3, pan-cytokeratin, and DNA. LNCaP and C4-2 androgen-responsive cells were used for in vitro assays including immunoprecipitation, western blotting, Luciferase reporter assay and quantitative polymerase chain reaction. Cell viability and migration assays were performed in prostate cancer cell lines using scrambled siRNA or siRNA targeting ING3. We find that ING3 levels and AR activity positively correlate in prostate cancer. ING3 potentiates androgen effects, increasing expression of androgen-regulated genes and androgen response element-driven reporters to promote growth and anchorage-independent growth. Conversely, ING3 knockdown inhibits prostate cancer cell growth and invasion. ING3 activates the AR by serving as a scaffold to increase interaction between TIP60 and the AR in the cytoplasm, enhancing receptor acetylation and translocation to the nucleus. Activation is independent of ING3's ability to target the TIP60 complex to H3K4Me3, identifying a previously unknown chromatin-independent cytoplasmic activity for ING3. In agreement with in vitro observations, analysis of The Cancer Genome Atlas (TCGA) data (n = 498) and a prostate cancer tissue microarray (n = 256) show that ING3 levels are higher in aggressive prostate cancers, with high levels of ING3 predicting shorter patient survival in a low AR subgroup. Including ING3 levels with currently used indicators such as the Gleason score provides more

  5. Engineering challenges in ING

    Energy Technology Data Exchange (ETDEWEB)

    Wolfe, W A

    1965-07-01

    With the Intense Neutron Generator (ING) we intend to produce a neutron flux of 10{sup 16} n/cm{sup 2} sec. Bismuth, bombarded by 1 GeV protons, yields about 20 neutrons per proton with a heat output of 23 MeV/neutron. A circulating liquid bismuth target will dissipate about 34 MW of heat. To produce the beam we will accelerate protons in a separated orbit cyclotron. The 65 mA current will require about 70-75 MW of radio-frequency power (50-200 Mc/s). We must generate and transmit RF efficiently. In ING precise magnet-fields, resonating-cavity electric-fields and well maintained vacuum (10{sup -6} torr) will place demands on most of today's engineering technology. (author)

  6. 75 FR 16456 - Inglis Hydropower, LLC; Notice Soliciting Scoping Comments

    Science.gov (United States)

    2010-04-01

    ... Hydropower, LLC; Notice Soliciting Scoping Comments March 26, 2010. Take notice that the following...: Inglis Hydropower, LLC. e. Name of Project: Inglis Hydropower Project. f. Location: The proposed project... Commission staff intends to prepare a single Environmental Assessment (EA) for the Inglis Hydropower Project...

  7. LACEwING: A New Moving Group Analysis Code

    Energy Technology Data Exchange (ETDEWEB)

    Riedel, Adric R. [Department of Astronomy, California Institute of Technology, Pasadena, CA 91125 (United States); Blunt, Sarah C.; Faherty, Jacqueline K. [Department of Astrophysics, American Museum of Natural History, New York, NY 10024 (United States); Lambrides, Erini L. [Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD 21218 (United States); Rice, Emily L. [Department of Engineering Science and Physics, The College of Staten Island, Staten Island, NY 10314 (United States); Cruz, Kelle L., E-mail: arr@astro.caltech.edu [Department of Physics and Astronomy, Hunter College, New York, NY 10065 (United States)

    2017-03-01

    We present a new nearby young moving group (NYMG) kinematic membership analysis code, LocAting Constituent mEmbers In Nearby Groups (LACEwING), a new Catalog of Suspected Nearby Young Stars, a new list of bona fide members of moving groups, and a kinematic traceback code. LACEwING is a convergence-style algorithm with carefully vetted membership statistics based on a large numerical simulation of the Solar Neighborhood. Given spatial and kinematic information on stars, LACEwING calculates membership probabilities in 13 NYMGs and three open clusters within 100 pc. In addition to describing the inputs, methods, and products of the code, we provide comparisons of LACEwING to other popular kinematic moving group membership identification codes. As a proof of concept, we use LACEwING to reconsider the membership of 930 stellar systems in the Solar Neighborhood (within 100 pc) that have reported measurable lithium equivalent widths. We quantify the evidence in support of a population of young stars not attached to any NYMGs, which is a possible sign of new as-yet-undiscovered groups or of a field population of young stars.

  8. Co-Story-ing: Collaborative Story Writing with Children Who Fear

    Science.gov (United States)

    Pehrsson, Dale-Elizabeth

    2007-01-01

    This article offers a guide for using collaborative story writing (co-story-ing), an assessment technique as well as a therapeutic intervention for children who demonstrate fears, extreme shyness and difficulty in establishing relationships. Co-story-ing draws from Gardner's Mutual Story Telling Technique. Co-story-ing guides clients as they…

  9. Modulators of inhibitor of growth (ING) family expression in development and disease.

    Science.gov (United States)

    Maher, Stacey K; Helbing, Caren C

    2009-05-01

    The inhibitor of growth (ING) gene family proteins regulate many critical cellular processes such as cell proliferation and growth, apoptosis, DNA repair, senescence, angiogenesis, and drug resistance. Their transcripts and proteins are differentially expressed in health and disease and there is evidence for developmental regulation. The vast majority of studies have characterized ING levels in the context of cancer. However, relatively little attention has been paid to the expression of ING family members in other contexts. This review summarizes the findings from human and animal model systems that provide insight into the factors influencing the expression of these important proteins. We examine the influence of cell cycle and aging as well as genotoxic stress on ING expression levels and evaluate several emerging areas of inquiry demonstrating that ING gene activity may be modulated by factors such as the p53 tumor suppressor, DNA methylation, and ING proteins themselves with external factors such as hormones, reactive oxygen species, TGFbeta signalling, and other proteins of pathological significance also influencing ING levels. We then briefly discuss the influence of post-translational modification and changes in subcellular localization as it pertains to modulation of ING expression. Understanding how ING expression is modulated represents a vital aspect of effective drug targeting strategies.

  10. The Cyborg Mermaid (or: How Technè Can Help the Misfits Fit In

    Directory of Open Access Journals (Sweden)

    Martine Mussies

    2017-02-01

    Full Text Available In feminist studies, the figure of the mermaid has long been regarded as flawed, disabled and less-than-human. Her theoretical counterpart in that respect would be the cyborg, an image used to show that with the aid of robotics, humankind could be larger than life. What would happen if we could combine those two images and apply them to create “super love” more-than-human relationships? This article explores the possibilities of technology for “mermaids”, people who normally fall outside the norm, to satisfy human desires in a new way. Two case studies will be presented, first we will look at people who identify as having ASD (Autism Spectre Disorders and second we explore the use of technology for people who have BDSM-oriented desires (related to Bondage and Discipline (B&D, Dominance and Submission (D&S, and Sadism and Masochism (S&M. We briefly discuss the added value of practice theory for exploring how people are altered by technè.

  11. Inge Lehmann’s work materials and seismological epistolary archive

    Directory of Open Access Journals (Sweden)

    Erik Hjortenberg

    2009-06-01

    Full Text Available

     

    The Inge Lehmann archive contains thousands of seismological work documents from Inge Lehmann’s private home. For a long time the author thought that the main concern was to keep the documents for posterity. There is now a renewed interest in Inge Lehmann, and some documents were presented in a poster at ESC Potsdam 2004, and the collection of documents were scanned and catalogued 2005-2006 at Storia Geofisica Ambiente in Bologna. Inge Lehmann (1888-1993 is famous for her discovery in 1936 of the earth’s inner core and for work on the upper mantle. A short biography is given. After her retirement in 1953 she worked at home in Denmark, and abroad in USA and in Canada. She took part in the creation of the European Seismological Commission in 1951, and in the creation of the International Seismological Centre in 1964. Inge Lehmann received many awards. Some letters from her early correspondence with Harold Jeffreys are discussed, they show how the inner core was discussed already in 1932. A few of the author’s reminiscences of Inge Lehmann are given.


  12. Elusloom lennukiga puhkusele / Inge Parring

    Index Scriptorium Estoniae

    Parring, Inge

    2003-01-01

    Ilmunud ka: Delovõje Vedomosti 1. okt. lk. 13. Air Cargo Estonia/ACE Logisticsi müügijuht Inge Parring tutvustab elusloomade transpordivõimalusi. Vt. samas: Loomade transportimiseks vajalikud dokumendid

  13. Nuclear localization signal of ING4 plays a key role in its binding to p53

    International Nuclear Information System (INIS)

    Zhang Xin; Wang Kesheng; Wang Zhiqin; Xu Lusheng; Wang Qingwan; Chen Fei; Wei Dongzhi; Han Zeguang

    2005-01-01

    ING4, a novel member of ING family, is recently reported to interact with tumor suppressor p53 and negatively regulate the cell growth with significant G2/M arrest of cell cycle in HepG2 cells through upregulation of p53-inducible gene p21. However, which region of ING4 could have contributed to the binding to p53 remains largely unclear. Herein, the GST-pulldown experiments revealed that the middle region of ING4, a potential bipartite nuclear localization signal (NLS), could be involved in the binding to p53. Furthermore, the interaction of ING4 to p53 was abrogated in vitro and in vivo when certain mutations or the entire deletion of the NLS domain occurred. More interestingly, the mutations of the NLS domain could alter the ING4 nuclear localization, disrupt the interaction of ING4 with p53, and even, deregulate the p53-inducible gene p21 in MCF-7 cells. All data indicated that the NLS domain of ING4 is essential for the binding of ING4 to p53 and the function of ING4 associated with p53

  14. Analisis Pemberian Antibiotik Berdasarkan Hasil Uji Sensitivitas Terhadap Pencapaian Clinical Outcome Pasien Infeksi Ulkus Diabetik Di RSUD Dr. H. Abdul Moeloek Lampung

    OpenAIRE

    Kahuripan, Ardiansyah; Andrajati, Retnosari; Syafridani, Tetty

    2009-01-01

    The administration of antibiotic at RSUD dr. H. Abdul Moeloek Lampung is based on sensitivity test result and empirical therapy on diabetic ulcer. Therefore, the objective of the research is to analyze the effectivity of various antibiotics adminis-tration based on the sensitivity test result on clinical outcome reached by consider-ing influenced factors. On the other hand, total evaluation of the resistances ofempirical antibiotic used by considering germ and sensitivity test feature was don...

  15. Técnica y educación desde un saber como techné a una tecnología del cuerpo/Technique and education from a knowledge as techné to a technology of the body

    Directory of Open Access Journals (Sweden)

    Virginia Alonso Sosa

    2007-01-01

    Full Text Available El propósito de este trabajo radica en una exploración sobre la noción de técnica corporal en distintos momentos de la historia de occidente, entendiendo la misma dentro de un concepto más amplio en cuanto a la técnica en general y por lo tanto relacionada al mundo del trabajo, la ciencia y la educación. En una mirada a la historia de las prácticas corporales, vemos que el concepto de técnica varía de acuerdo al período estudiado, así como los trabajos que sobre lo corporal realizan distintas culturas. Nuestra exploración tomará como referencia: la antigua Grecia, con su concepto de techné; la Edad Media y la Modernidad como escenario clave en el que se funda la Educación Física. Nos proponemos, en este trabajo, rescatar la noción de técnica corporal como concepto amplio, presente en toda actividad humana, valorándola como construcción cultural tradicional en lo que se refiere a los usos del cuerpo. Esta visión es un intento por no reducir el concepto de técnica al de una tecnología del cuerpo, solidaria con un tecnicismo dominante desde fines del siglo XIX, muy presente en la educación. The purpose of this paper is based on an exploration into the notion of body technique at different times in the occidental history, regarding it within a broader concept in relation to technique in general, and therefore related to the world of work, science and education. Looking at the history of the practices with the body, we see that the concept of technique varies according to the studied period, just as the works that different cultures do about the use of the body. Our exploration will refer to ancient Greece, with its concept of techné; the Middle Ages and the Modern Period as a crucial stage where Physical Education was born. Our aim in this paper is to rescue the notion of body technique as a broad concept, present in every human activity, valuing it as a traditional human construction in what refers to the uses of the body

  16. 75 FR 65620 - Inglis Hydropower, LLC; Notice of Application Ready for Environmental Analysis and Soliciting...

    Science.gov (United States)

    2010-10-26

    ... Hydropower, LLC; Notice of Application Ready for Environmental Analysis and Soliciting Comments...: Inglis Hydropower, LLC. e. Name of Project: Inglis Hydropower Project. f. Location: The project would be... ready for environmental analysis at this time. l. The proposed 2.0-megawatt Inglis Hydropower Project...

  17. ING Genes Work as Tumor Suppressor Genes in the Carcinogenesis of Head and Neck Squamous Cell Carcinoma

    Directory of Open Access Journals (Sweden)

    Xiaohan Li

    2011-01-01

    Full Text Available Head and neck squamous cell carcinoma (HNSCC is the sixth most common cancer in the world. The evolution and progression of HNSCC are considered to result from multiple stepwise alterations of cellular and molecular pathways in squamous epithelium. Recently, inhibitor of growth gene (ING family consisting of five genes, ING1 to ING5, was identified as a new tumor suppressor gene family that was implicated in the downregulation of cell cycle and chromatin remodeling. In contrast, it has been shown that ING1 and ING2 play an oncogenic role in some cancers, this situation being similar to TGF-β. In HNSCC, the ING family has been reported to be downregulated, and ING translocation from the nucleus to the cytoplasm may be a critical event for carcinogenesis. In this paper, we describe our recent results and briefly summarize current knowledge regarding the biologic functions of ING in HNSCC.

  18. De quels ingénieurs parle-t-on ? Situation et trajectoires des ingénieurs des grandes écoles. Le cas du Maroc

    Directory of Open Access Journals (Sweden)

    Pierre Vermeren

    2009-05-01

    Full Text Available Cet article est consacré au cas des « ingénieurs de conception » marocains, formés la plupart du temps dans les grandes écoles françaises. Cette fraction des ingénieurs marocains (dont la majorité est formée dans les écoles d'ingénieurs du Maroc n'est pas loin de constituer une véritable aristocratie de fonction. Ce phénomène illustre la structure sociale très inégalitaire du Maroc et la stratification opérée par la monarchie (le Makhzen pour sélectionner ses élites, qui sont aujourd'hui des élites à la fois technocratiques et sociales. Cette domination des « technocrates » sur l'appareil d'Etat marocain, analysée ici à travers des publics étudiants de grandes écoles, s'accompagne de l'émergence d'une contre-élite sociale de contestation. Les écoles d'ingénieurs de second rang, peuplées par les éléments des classes moyennes, ont été le premier terreau des mouvements islamistes en milieu universitaire. Elles produisent aujourd'hui une contre-élite politique et sociale qui piétine aux portes du vrai pouvoir.

  19. 47{sup th} Annual meeting on nuclear technology (AMNT 2016). Key Topic / Outstanding know-how and sustainable excellence. Workshop: Preserving competence in nuclear technology

    Energy Technology Data Exchange (ETDEWEB)

    Steinwarz, Wolfgang

    2016-10-15

    On the 18{sup th} workshop Preserving Competence in Nuclear Technology 24 young scientists presented the scientific results from their work covering a broad spectrum of technical areas. This demonstrated again the strong engagement of the younger generation as part of the German nuclear society. Prof.Dr.-Ing. Eckart Laurin, Prof.Dr.-Ing. Marco K. Koch, Dr. Katharina Stummeyer, and Dr.-Ing. Wolfgang Steinwarz as members of the jury assessed the written compacts and the oral presentations to award the Siempelkamp Competence Price 2016 to Andreas Wanninger from Technische Universitaet Muenchen.

  20. 47th Annual meeting on nuclear technology (AMNT 2016). Key Topic / Outstanding know-how and sustainable excellence. Workshop: Preserving competence in nuclear technology

    International Nuclear Information System (INIS)

    Steinwarz, Wolfgang

    2016-01-01

    On the 18 th workshop Preserving Competence in Nuclear Technology 24 young scientists presented the scientific results from their work covering a broad spectrum of technical areas. This demonstrated again the strong engagement of the younger generation as part of the German nuclear society. Prof.Dr.-Ing. Eckart Laurin, Prof.Dr.-Ing. Marco K. Koch, Dr. Katharina Stummeyer, and Dr.-Ing. Wolfgang Steinwarz as members of the jury assessed the written compacts and the oral presentations to award the Siempelkamp Competence Price 2016 to Andreas Wanninger from Technische Universitaet Muenchen.

  1. Colloquium held in honour of Prof.em.Dr.-Ing. F. Adler and Prof.Dr.-Ing. Dr.h.c. F.L. Wilke

    International Nuclear Information System (INIS)

    1992-01-01

    The following subjects are discussed: Acceptance of social responsibility; introduction of a management information system B-FIS at Friedrich Heinrich mine; new engineering tasks in reinsurance; mining education and the mining industry; exodus of German mining engineers; developments in shaft drilling in the last 20 years. (HS) [de

  2. ING1 and 5-azacytidine act synergistically to block breast cancer cell growth.

    Directory of Open Access Journals (Sweden)

    Satbir Thakur

    Full Text Available Inhibitor of Growth (ING proteins are epigenetic "readers" that recognize trimethylated lysine 4 of histone H3 (H3K4Me3 and target histone acetyl transferase (HAT and histone deacetylase (HDAC complexes to chromatin.Here we asked whether dysregulating two epigenetic pathways with chemical inhibitors showed synergistic effects on breast cancer cell line killing. We also tested whether ING1 could synergize better with chemotherapeutics that target the same epigenetic mechanism such as the HDAC inhibitor LBH589 (Panobinostat or a different epigenetic mechanism such as 5-azacytidine (5azaC, which inhibits DNA methyl transferases. Simultaneous treatment of breast cancer cell lines with LBH589 and 5azaC did not show significant synergy in killing cells. However, combination treatment of ING1 with either LBH589 or 5azaC did show synergy. The combination of ING1b with 5azaC, which targets two distinct epigenetic mechanisms, was more effective at lower doses and enhanced apoptosis as determined by Annexin V staining and cleavage of caspase 3 and poly-ADP-ribose polymerase (PARP. ING1b plus 5azaC also acted synergistically to increase γH2AX staining indicating significant levels of DNA damage were induced. Adenoviral delivery of ING1b with 5azaC also inhibited cancer cell growth in a murine xenograft model and led to tumor regression when viral concentration was optimized in vivo.These data show that targeting distinct epigenetic pathways can be more effective in blocking cancer cell line growth than targeting the same pathway with multiple agents, and that using viral delivery of epigenetic regulators can be more effective in synergizing with a chemical agent than using two chemotherapeutic agents. This study also indicates that the ING1 epigenetic regulator may have additional activities in the cell when expressed at high levels.

  3. Idiopathic nodular glomerulosclerosis (ING) in an African American (AA) man with hepatitis C.

    Science.gov (United States)

    Onteddu, Nirmal K; Duggirala, Jayasri; Reddy, Anand C

    2018-05-18

    Idiopathic nodular glomerulosclerosis (ING) in a non-diabetic patient is uncommon. Nodular glomerulosclerosis is hallmark sign of diabetic nephropathy. ING is a very rare clinicopathological disease associated with smoking, obesity and hypertension, chronic obstructive pulmonary disease and metabolic syndrome. A 68-year-old non-obese African American man with hypertension, smoking and history of hepatitis C presented to the clinic with progressive worsening of lower extremity oedema and declining renal function over few months. Renal biopsy demonstrated nodular glomerulosclerosis. In this case, ING is hypothesised to be associated with hepatitis C along with smoking and hypertension (HTN). We present this case to speculate the existence of yet unknown aetiologies of ING. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  4. ING status report July 1967

    Energy Technology Data Exchange (ETDEWEB)

    Church, T G

    1967-07-01

    Evolution of ING from initial concept to advanced systems and the interplay between participating disciplines are illustrated in Fig. 1.2. Anticipated requirements for intense continuous fluxes of thermal neutrons set the initial goal and dictated the scale and other guidelines of the system including the desired completion date. While neutron applications were given prime consideration in conceptual planning, much wider fields of research, both pure and applied, would benefit from the facility now being studied. (author)

  5. ING status report July 1967

    International Nuclear Information System (INIS)

    Church, T.G.

    1967-01-01

    Evolution of ING from initial concept to advanced systems and the interplay between participating disciplines are illustrated in Fig. 1.2. Anticipated requirements for intense continuous fluxes of thermal neutrons set the initial goal and dictated the scale and other guidelines of the system including the desired completion date. While neutron applications were given prime consideration in conceptual planning, much wider fields of research, both pure and applied, would benefit from the facility now being studied. (author)

  6. introduction à l'ingénierie documentaire et aux sciences de l'information

    OpenAIRE

    Guyot, Brigitte

    2011-01-01

    polycopié introductif pour la formation chef de projet en ingénierie documentaire, Cnam; introductory course on documentary engineering: definition, applications, objects, process, actors of the market, historical elements; cours introductif à l'ingénierie documentaire : positionnement, objets, processus, acteurs du marché, repères historiques

  7. Immediate relation of ING to fast breeder reactor programs

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, W B

    1969-07-01

    The future large-scale use of nuclear energy is linked in the United States and other major countries to their fast breeder reactor development. Very serious basic problems have been discovered within the last two years, limiting the life in the high fast neutron flux at appropriate temperatures of materials, in particular of metals suitable for fuel cladding in sodium coolant. There is therefore a most urgent need for materials testing facilities under controlled conditions of temperature and neutron flux at sufficiently high ratings to match or surpass those required in commercially competitive fast breeder reactors. None of the test facilities yet planned for 1976 or sooner in the western world appears to match these conditions. The problem is mainly the difficulty of providing the high neutron flux effectively continuously. The spallation reaction in heavy elements was chosen as the basis of ING - the intense neutron generator, because it is the only known reaction that promises a fast neutron source density that is higher than can be controlled from the fission process. It is suggested that several countries will wish to consider urgently whether they should also explore the spallation reaction for the purpose of a fast neutron irradiation test facility. In view of the discontinuance of the ING project in Canada a favourable opportunity will exist over the next few months 10 obtain from Canada by direct personal contact details of the significant study that has been carried on for ING over the last five years. In the event that satisfactory materials are established within the lifetime of the spallation facilities they may continue to be used for the production of selected isotopes more profitably produced in high neutron fluxes. The facilities may be also used for the desirable preirradiation of thorium reactor fuel. The other research purposes planned for ING could also be served. (author)

  8. Immediate relation of ING to fast breeder reactor programs

    International Nuclear Information System (INIS)

    Lewis, W.B.

    1969-01-01

    The future large-scale use of nuclear energy is linked in the United States and other major countries to their fast breeder reactor development. Very serious basic problems have been discovered within the last two years, limiting the life in the high fast neutron flux at appropriate temperatures of materials, in particular of metals suitable for fuel cladding in sodium coolant. There is therefore a most urgent need for materials testing facilities under controlled conditions of temperature and neutron flux at sufficiently high ratings to match or surpass those required in commercially competitive fast breeder reactors. None of the test facilities yet planned for 1976 or sooner in the western world appears to match these conditions. The problem is mainly the difficulty of providing the high neutron flux effectively continuously. The spallation reaction in heavy elements was chosen as the basis of ING - the intense neutron generator, because it is the only known reaction that promises a fast neutron source density that is higher than can be controlled from the fission process. It is suggested that several countries will wish to consider urgently whether they should also explore the spallation reaction for the purpose of a fast neutron irradiation test facility. In view of the discontinuance of the ING project in Canada a favourable opportunity will exist over the next few months 10 obtain from Canada by direct personal contact details of the significant study that has been carried on for ING over the last five years. In the event that satisfactory materials are established within the lifetime of the spallation facilities they may continue to be used for the production of selected isotopes more profitably produced in high neutron fluxes. The facilities may be also used for the desirable preirradiation of thorium reactor fuel. The other research purposes planned for ING could also be served. (author)

  9. The inhibitor of growth protein 5 (ING5 depends on INCA1 as a co-factor for its antiproliferative effects.

    Directory of Open Access Journals (Sweden)

    Feng Zhang

    Full Text Available The proteins of the Inhibitor of Growth (ING family are involved in multiple cellular functions such as cell cycle regulation, apoptosis, and chromatin remodeling. For ING5, its actual role in growth suppression and the necessary partners are not known. In a yeast-two-hybrid approach with human bone marrow derived cDNA, we identified ING5 as well as several other proteins as interaction partners of Inhibitor of cyclin A1 (INCA1 that we previously characterized as a novel interaction partner of cyclin A1/CDK2. ING5 expression in leukemic AML blasts was severely reduced compared to normal bone marrow. In line, ING5 inhibited bone marrow colony formation upon retroviral transduction. However, Inca1(-/- bone marrow colony formation was not suppressed by ING5. In murine embryonic fibroblast (MEF cells from Inca1(+/+ and Inca1(-/- mice, overexpression of ING5 suppressed cell proliferation only in the presence of INCA1, while ING5 had no effect in Inca1(-/- MEFs. ING5 overexpression induced a delay in S-phase progression, which required INCA1. Finally, ING5 overexpression enhanced Fas-induced apoptosis in Inca1(+/+ MEFs, while Inca1(-/- MEFs were protected from Fas antibody-induced apoptosis. Taken together, these results indicate that ING5 is a growth suppressor with suppressed expression in AML whose functions depend on its interaction with INCA1.

  10. Validation and industrial application of AFM

    DEFF Research Database (Denmark)

    Kofod, Niels

    This thesis has been prepared as one of the requirements of the industrial researcher and Ph.D- degree. This thesis represented the 2 nd version of this thesis. The work has been carried out from January 1999 to January 2002 at The Danish Institute of Fundamental Metrology (DFM) and The Institute...... of Manufacturing Engineering and Management (IPL), Technical University of Denmark (DTU). The work has been carried out under supervision from Dr. Jørgen Garnæs, DFM, Dr. Techn. Leonardo De Chiffre, IPL/DTU and Dr. Hans Nørgaard Hansen. I would like to thank my supervisors for their inspiration and valuable...

  11. 78 FR 39023 - ING Investments, LLC, et al.;

    Science.gov (United States)

    2013-06-28

    ... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 30566; File No. 812-14111] ING Investments, LLC, et al.; Notice of Application June 24, 2013. AGENCY: Securities and Exchange Commission (``Commission''). ACTION: Notice of an application under section 6(c) of the Investment Company...

  12. The 'Techniques de l'ingénieur' available online at CERN!

    CERN Multimedia

    2001-01-01

    Those already familiar with 'Techniques de l'ingénieur' will be delighted. This engineering technology database widely known among French-speaking engineers and technicians can now be consulted online from the CERN Intranet until the end of the summer. To access this database of reference articles in French, all you need to do is go to the CERN Library's Web pages (http://library.cern.ch) and click on the 'Techniques de l'ingénieur' link under the 'News' heading. The Library will be monitoring the use of the database for a couple of months, at the end of which an access licence may be negotiated. Don't hesitate to use it because the decision whether or not to purchase it will depend on the extent to which it is used. The Library is seeking partners within the Laboratory to finance the purchase if it is decided to go ahead with it. Contributions from the CERN community are therefore welcome. For those who are not yet familiar with it, the 'Techniques de l'ingénieur' database ...

  13. 77 FR 58375 - Inglis Hydropower, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2012-09-20

    ... Hydropower, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications On May 18, 2012, Inglis Hydropower, LLC filed an... study the feasibility of a hydropower project located at the Inglis Bypass Channel, located on the...

  14. Autogenous Phenomena in Cement-Based Materials

    DEFF Research Database (Denmark)

    Jensen, Ole Mejlhede

    Denne afhandling er skrevet med henblik på opnåelse af den danske doktorgrad i teknik, dr.techn. Den vedrører autogene fænomener i cementbaserede materialer – primært deformation og ændring af den relative luftfugtighed (RF). I afhandlingen er det belyst, hvordan betydningen af disse fænomener bl...

  15. Pour une ingénierie des Environnements Informatiques pour l'Apprentissage Humain

    OpenAIRE

    Tchounikine , Pierre

    2002-01-01

    Nous proposons dans cet article une réflexion sur la notion d'ingénierie des EIAH (Environnements Informatiques pour l'Apprentissage Humain). Nous posons tout d'abord une définition de l'ingénierie des EIAH : travaux visant à définir des éléments de méthodes et de techniques reproductibles et/ou réutilisables facilitant la mise en place (conception – réalisation – expérimentation – évaluation - diffusion) d'environnements de formation ou d'apprentissage (dans leur articulation avec les dispos...

  16. The ING Seismic Network Databank (ISND : a friendly parameters and waveform database

    Directory of Open Access Journals (Sweden)

    G. Smriglio

    1995-06-01

    Full Text Available he Istituto Nazionale di Geofisica (ING Seismic Network Database (ISND includes over 300000 arrivaI times of Italian, Mediterranean and teleseismic earthquakes from 1983 to date. This database is a useful tool for Italian and foreign seismologists ( over 1000 data requests in the first 6 months of this year. Recently (1994 the ING began storing in the ISND, the digital waveforms associated with arri,Tal times and experimen- tally allowed users to retrieve waveforms recorded by the ING acquisition system. In this paper we describe the types of data stored and the interactive and batch procedures available to obtain arrivaI times and/or asso- ciated waveforms. The ISND is reachable via telephone line, P.S.I., Internet and DecNet. Users can read and send to their E-mail address alI selected earthquakes locations, parameters, arrivaI times and associated digital waveforms (in SAC, SUDS or ASCII format. For r;aedium or large amounts of data users can ask to receive data by means of magnetic media (DAT, Video 8, floppy disk.

  17. How Inge Lehmann Discovered the Inner Core of the Earth

    Science.gov (United States)

    Rousseau, Christiane

    2013-01-01

    The mathematics behind Inge Lehmann's discovery that the inner core of the Earth is solid is explained using data collected around the Earth on seismic waves and their travel time through the Earth.

  18. 76 FR 45303 - ING Asia Pacific High Dividend Equity Income Fund, et al.; Notice of Application

    Science.gov (United States)

    2011-07-28

    ... Premium Opportunity Fund (``IGA''); ING Global Equity Dividend and Premium Opportunity Fund (``IGD''); ING... Exchange. PRT has also issued preferred shares. Each Current Fund reserves the right to issue preferred... market price and its net asset value per common share (``NAV'')) and the relationship between such Fund's...

  19. 75 FR 10230 - Inglis Hydropower, LLC; Notice of Application Accepted for Filing and Soliciting Motions To...

    Science.gov (United States)

    2010-03-05

    ... Hydropower, LLC; Notice of Application Accepted for Filing and Soliciting Motions To Intervene and Protests... No.: P-12783-003. c. Date filed: July 22, 2009. d. Applicant: Inglis Hydropower, LLC. e. Name of Project: Inglis Hydropower Project. f. Location: The proposed project would be located at the existing...

  20. Dr Luigi Orlando, Dr Sergio Ceccuzzi, Dr. Armando Sbrana, Europa Metalli, Italy, Dr Albert Scherger, Member of KM Europa Metal AG, Osnabr ck, Germany, Prof. Filippo Menzinger, Scientific Attaché, Permanent Mission of Italy in Geneva

    CERN Multimedia

    Patrice Loïez

    2001-01-01

    Photo 01: Dr Lyn Evans and Dr Luigi Orlando Photo 04: L. to r.: Dr Lyn Evans, Dr Luigi Orlando, Prof. Luciano Maiani and Prof. Filippo Menzinger Photo 06: L. to r.: Prof. Philippo Menzinger, Dr Armando Sbrana, Prof. Luciano Maiani, Dr Albert Scherger, Dr Lyn Evans, Dr Luigi Orlando, Dr Sergio Ceccuzzi, visiting the LHC superconducting magnet test hall, SM18

  1. Efficacy of combining ING4 and TRAIL genes in cancer-targeting gene virotherapy strategy: first evidence in preclinical hepatocellular carcinoma.

    Science.gov (United States)

    Galal El-Shemi, A; Mohammed Ashshi, A; Oh, E; Jung, B-K; Basalamah, M; Alsaegh, A; Yun, C-O

    2018-01-01

    Current treatments of hepatocellular carcinoma (HCC) are ineffective and unsatisfactory in many aspects. Cancer-targeting gene virotherapy using oncolytic adenoviruses (OAds) armed with anticancer genes has shown efficacy and safety in clinical trials. Nowadays, both inhibitor of growth 4 (ING4), as a multimodal tumor suppressor gene, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), as a potent apoptosis-inducing gene, are experiencing a renaissance in cancer gene therapy. Herein we investigated the antitumor activity and safety of mono- and combined therapy with OAds armed with ING4 (Ad-ΔB/ING4) and TRAIL (Ad-ΔB/TRAIL) gene, respectively, on preclinical models of human HCC. OAd-mediated expression of ING4 or TRAIL transgene was confirmed. Ad-ΔB/TRAIL and/or Ad-ΔB/ING4 exhibited potent killing effect on human HCC cells (HuH7 and Hep3B) but not on normal liver cells. Most importantly, systemic therapy with Ad-ΔB/ING4 plus Ad-ΔB/TRAIL elicited more eradicative effect on an orthotopic mouse model of human HCC than their monotherapy, without causing obvious overlapping toxicity. Mechanistically, Ad-ΔB/ING4 and Ad-ΔB/TRAIL were remarkably cooperated to induce antitumor apoptosis and immune response, and to repress tumor angiogenesis. This is the first study showing that concomitant therapy with Ad-ΔB/ING4 and Ad-ΔB/TRAIL may provide a potential strategy for HCC therapy and merits further investigations to realize its possible clinical translation.

  2. Dræb, dræb, dræb! Nej ... liiiige et øjeblik: De machiavelliske følelser i Game of Thrones

    DEFF Research Database (Denmark)

    Schubart, Rikke

    2013-01-01

    Blogindlæg om Machiavelliske følelser i HBO tv-serien Game of Thrones: "Dræb, dræb, dræb! Nej ... liiiige et øjeblik: De machiavelliske følelser i Game of Thrones"......Blogindlæg om Machiavelliske følelser i HBO tv-serien Game of Thrones: "Dræb, dræb, dræb! Nej ... liiiige et øjeblik: De machiavelliske følelser i Game of Thrones"...

  3. Ingénierie des compétences et scénarisation pédagogique

    Directory of Open Access Journals (Sweden)

    Josianne Basque

    2007-01-01

    Full Text Available Cet article décrit un processus d’ingénierie éducative orienté compétences d’une activité d’autoévaluation et son intégration à un scénario pédagogique de cours à distance. Cette description est documentée par deux cas d’application dans un contexte de formation universitaire à distance. Le travail d’ingénierie utilise une approche en autogestion des compétences pour concevoir l’activité d’autoévaluation et l’instrumentaliser avec l’outil logiciel web d’autodiagnostic des compétences, appelé Compétences+. Cet acte d’ingénierie pédagogique porte l’attention de l’enseignant-concepteur sur une démarche centrée sur l’apprentissage dans une perspective d’autogestion des connaissances et de sa validation dans un usage en contexte isomorphe à une situation professionnelle réelle.

  4. Radioprotection et ingénierie nucléaire

    CERN Document Server

    2006-01-01

    Le développement de l'énergie nucléaire repose sur deux piliers essentiels : la sûreté nucléaire, qui concerne la machine, et la radioprotection, qui se préoccupe des hommes. Construit de manière fiable, un réacteur nucléaire se doit d'irradier le moins possible ses opérateurs et conduire à un impact très faible pour les populations avoisinantes. Tout cela est soumis à des règles strictes, élaborées au niveau international, et qui ne tolèrent aucun écart. Les ingénieurs qui ont à concevoir, construire et conduire ces machines doivent maîtriser les règles de protection : cet ouvrage leur est destiné. La radioprotection, si elle se fonde principalement sur des bases scientifiques, intègre également une dimension sociétale exigeante. Ces activités sont en effet sous le regard critique et permanent de nos concitoyens, qui exigent des acteurs de cette industrie une maîtrise totale de la radioprotection ; un ingénieur qui ne connaîtrait pas la genèse de la radioprotection, ses règle...

  5. Loyola University distingue al Ing. Martínez

    OpenAIRE

    Lezcano, Liseth

    2011-01-01

    El Ing. Axel Martínez, Director de Recursos Humanos de la Universidad Tecnológica de Panamá (UTP), recibió un reconocimiento que le hizo el Instituto de Recursos Humanos y Relaciones Industriales de Loyola University Chicago (LUC), como egresado destacado del Programa de Maestría en Recursos Humanos, por la prestigiosa carrera académica y por sus éxitos profesionales en un importante ambiente académico.

  6. Cooperation of Ad-hING4 and 125I seed in tumor-suppression on human pancreatic cancer xenograft in nude mice

    International Nuclear Information System (INIS)

    Zhai Hongyan; Fa Yihua; Su Chenghai; Yang Jicheng; Sheng Weihua; Xie Yufeng

    2009-01-01

    This work is to investigate the combined tumor-suppression effect of Adenovirus-mediated human ING4 (Ad-hING4) and 125 I seed on human pancreatic cancer xenograft and the possible mechanisms. Ad-hING4 recombinant adenovirus vector was transected into QBI-293A cells and high titre adenovirus was obtained. Subcutaneous tumor models were established with 25 nude mice with human pancreatic cancer cell line PANC-1. They were randomly divided into 5 groups: PBS control group, Ad carrier group, 125 I seed brachytherapy group, Ad-hING4 gene treatment group, combined 125 I seed and Ad-hING4 group. The tumor volumes were measured every 5 days after treatment, and were sacrificed on the 20th day. The tumors were measured and weighed to determine the ratio of tumor-suppression and Jin-Shi q value. Morphological changes of tumor cells,the tissue injury and apoptotic index AI were examined on pathological sections. MVD, Survivin and Caspase3 were tested in immunohistochemistry. The results show that the tumor-suppressive ratio of the 125 I seed group, Ad-hING4 group, combined treatment group were,respectively, 34.19%(P 0.05). It can be concluded that 125 I seed and Ad-hING4 inhibit the growth of PANC-1 pancreatic cancer on nude mice significantly. These indicate a synergy of the combined treatments in tumor-suppression and Ad-hING4 is a promising novel radiosensitizer. The mechanisms of tumor-suppressive may be multi-pathways such as down-regulation the expression of Survivin and up-regulation the expression of Caspase3 to induce apoptosis and inhibit angiogenesis. (authors)

  7. Linnagaleriis avati ülevaatenäitus 'Pärnu sügis 98' / Leonhard Lapin, Inge Teder ; interv. Tiiu Leis

    Index Scriptorium Estoniae

    Lapin, Leonhard, 1947-

    1998-01-01

    14. okt avati Pärnu Linnagaleriis Pärnu kunstnike maalinäitus, töid valisid Kunstiakadeemia õppejõud Leonhard Lapin ja Inge Teder ning Linnagalerii nõukogu liige Feliks Krapp. Intervjuu L. Lapini ja Inge Tederiga.

  8. Detennination Qf Optimuni on-fann Seed Pri~ing Time for Maize ...

    African Journals Online (AJOL)

    maize seed to on-far111 priming is an important development which can be used to improve ... Key words: semi-arid: crop establishment; sorghum; maize: on-farm seed priming; Zimbapwe. ... faster growth and higher yield after seed prim-, ing.

  9. FoRSIC : De l'ingénierie des compétences à l'ingénierie des connaissances.

    OpenAIRE

    Ertzscheid , Olivier; Link-Pezet , Jo; Lacombe , Elisabeth

    2002-01-01

    FoRSIC [1] est un dispositif d'ingénierie des connaissances, qui s'ancre dans le champ de la formation à la recherche documentaire. Après avoir précisé le contexte théorique qui le sous-tend, nous décrirons ici les méthodologies qui nous ont permis de faire émerger des représenta-tions structurantes et partageables de ce domaine, à l'aide d'une ontologie des compétences docu-mentaires que nous relions au réseau sémantique du modèle de domaine.

  10. SCFJFK is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer

    Science.gov (United States)

    Yan, Ruorong; He, Lin; Li, Zhongwu; Han, Xiao; Liang, Jing; Si, Wenzhe; Chen, Zhe; Li, Lei; Xie, Guojia; Li, Wanjin; Wang, Peiyan; Lei, Liandi; Zhang, Hongquan; Pei, Fei; Cao, Dengfeng

    2015-01-01

    Loss of function/dysregulation of inhibitor of growth 4 (ING4) and hyperactivation of NF-κB are frequent events in many types of human malignancies. However, the molecular mechanisms underlying these remarkable aberrations are not understood. Here, we report that ING4 is physically associated with JFK. We demonstrated that JFK targets ING4 for ubiquitination and degradation through assembly of an Skp1–Cul1–F-box (SCF) complex. We showed that JFK-mediated ING4 destabilization leads to the hyperactivation of the canonical NF-κB pathway and promotes angiogenesis and metastasis of breast cancer. Significantly, the expression of JFK is markedly up-regulated in breast cancer, and the level of JFK is negatively correlated with that of ING4 and positively correlated with an aggressive clinical behavior of breast carcinomas. Our study identified SCFJFK as a bona fide E3 ligase for ING4 and unraveled the JFK–ING4–NF-κB axis as an important player in the development and progression of breast cancer, supporting the pursuit of JFK as a potential target for breast cancer intervention. PMID:25792601

  11. La sauvegarde des grandes oeuvres de l'ingénierie du XXème siècle

    CERN Document Server

    Graf, Franz

    2016-01-01

    Consacré à la sauvegarde des grandes oeuvres de l’ingénierie du XXe siècle, ce premier numéro des Cahiers du TSAM explore le devenir de certaines des plus remarquables et emblématiques structures en béton du siècle passé. A travers les fi gures d’héroïques constructeurs, il interroge l’héritage construit des ingénieurs, convoquant les plus audacieux d’entre eux (Freyssinet, Isler, Maillart, Nervi, Vierendeel, etc.). Alors que la sauvegarde de l’architecture du XXe siècle s’est récemment constituée en discipline à part entière, la préservation des ouvrages de l’ingénierie de cette période est encore balbutiante. Considérés trop souvent sous le seul point de vue de la sécurité ou de la maintenance, ces ouvrages s’avèrent parfois de véritables chefs-d’oeuvre, jalons d’un «art de l’ingénieur» à la frontière entre performance technique et beauté plastique. Ces cahiers sont donc l’occasion d’initier, à l’appui d’exemples et de projets de sauvegarde con...

  12. 8th Argentinean Bioengineering Society Conference (SABI 2011) and 7th Clinical Engineering Meeting

    Science.gov (United States)

    Meschino, Gustavo Javier; Ballarin, Virginia L.

    2011-12-01

    President Dr Gustavo Meschino Universidad Nacional de Mar del Plata Comittee Dr Gustavo Abraham Universidad Nacional de Mar del Plata - CONICET Mg Rubén Acevedo Universidad Nacional de Entre Ríos Ing Pablo Agüero Universidad Nacional de Mar del Plata Ing Mariela Ambrustolo Universidad Nacional de Mar del Plata Dr Ricardo Armentano Universidad Favaloro Dra Virginia L Ballarin Universidad Nacional de Mar del Plata Dra Josefina Ballarre Universidad Nacional de Mar del Plata - CONICET Dr Eduardo Blotta Universidad Nacional de Mar del Plata Ing Marco Benalcázar Universidad Nacional de Mar del Plata Mg Freddy Geovanny Benalcázar Palacios Escuela Superior Politécnica de Chimborazo, Ecuador Dr Roberto Boeri Universidad Nacional de Mar del Plata - CONICET - INTEMA Dra Agustina Bouchet Universidad Nacional de Mar del Plata Dr Ariel Braidot Universidad Nacional de Entre Ríos Dr Marcel Brun Universidad Nacional de Mar del Plata Dra Silvia Ceré Universidad Nacional de Mar del Plata - CONICET Ing Fernando Clara Universidad Nacional de Mar del Plata Dr Raúl Correa Prado Universidad Nacional de San Juan Bioing Pablo Cortez Universidad Nacional de Mar del Plata Dra Teresita R Cuadrado Universidad Nacional de Mar del Plata - CONICET Ing Eduardo De Forteza Universidad Favaloro Dra Mariana Del Fresno Universidad Nacional del Centro de la Provincia de Buenos Aires Dr Martín Diaz Informática Médica Hospital Aleman de Buenos Aires - GIBBA Ing Julio César Doumecq Universidad Nacional de Mar del Plata Mg Ana María Echenique Universidad Nacional de San Juan Bioing Pedro Escobar Universidad Nacional del Centro, Olavarría, Pcia de Buenos Aires Dr Fernando Daniel Farfán Universidad Nacional de Tucumán Dr Carmelo Felice Universidad Nacional de Tucumán - CONICET Dr Elmer Fernández Universidad Católica de Córdoba - CONICET Ing José Flores Universidad Nacional de Entre Ríos Dr Arturo Gayoso Universidad Nacional de Mar del Plata Dra Bioing Agustina Garcés Universidad Nacional de San

  13. 77 FR 74245 - ING Investments, LLC, et al.; Notice of Application

    Science.gov (United States)

    2012-12-13

    ... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 30295; 812-14013] ING Investments, LLC, et al.; Notice of Application December 6, 2012. AGENCY: Securities and Exchange Commission (``Commission''). ACTION: Notice of application for an order under section 17(d) of the Investment Company Act...

  14. SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer.

    Science.gov (United States)

    Yan, Ruorong; He, Lin; Li, Zhongwu; Han, Xiao; Liang, Jing; Si, Wenzhe; Chen, Zhe; Li, Lei; Xie, Guojia; Li, Wanjin; Wang, Peiyan; Lei, Liandi; Zhang, Hongquan; Pei, Fei; Cao, Dengfeng; Sun, Luyang; Shang, Yongfeng

    2015-03-15

    Loss of function/dysregulation of inhibitor of growth 4 (ING4) and hyperactivation of NF-κB are frequent events in many types of human malignancies. However, the molecular mechanisms underlying these remarkable aberrations are not understood. Here, we report that ING4 is physically associated with JFK. We demonstrated that JFK targets ING4 for ubiquitination and degradation through assembly of an Skp1-Cul1-F-box (SCF) complex. We showed that JFK-mediated ING4 destabilization leads to the hyperactivation of the canonical NF-κB pathway and promotes angiogenesis and metastasis of breast cancer. Significantly, the expression of JFK is markedly up-regulated in breast cancer, and the level of JFK is negatively correlated with that of ING4 and positively correlated with an aggressive clinical behavior of breast carcinomas. Our study identified SCF(JFK) as a bona fide E3 ligase for ING4 and unraveled the JFK-ING4-NF-κB axis as an important player in the development and progression of breast cancer, supporting the pursuit of JFK as a potential target for breast cancer intervention. © 2015 Yan et al.; Published by Cold Spring Harbor Laboratory Press.

  15. Galande, Dr Sanjeev

    Indian Academy of Sciences (India)

    Elected: 2010 Section: General Biology. Galande, Dr Sanjeev Ph.D. (IISc). Date of birth: 20 September 1967. Specialization: Epigenetics, Chromatin Biology, Gene Regulation, Genomics and Proteomics Address: Centre for Excellence in Epigenetics, Indian Institute of Science Education, & Research, Dr Homi Bhabha Road, ...

  16. Gaia DR2 documentation

    Science.gov (United States)

    van Leeuwen, F.; de Bruijne, J. H. J.; Arenou, F.; Bakker, J.; Blomme, R.; Busso, G.; Cacciari, C.; Castañeda, J.; Cellino, A.; Clotet, M.; Comoretto, G.; Eyer, L.; González-Núñez, J.; Guy, L.; Hambly, N.; Hobbs, D.; van Leeuwen, M.; Luri, X.; Manteiga, M.; Pourbaix, D.; Roegiers, T.; Salgado, J.; Sartoretti, P.; Tanga, P.; Ulla, A.; Utrilla Molina, E.; Abreu, A.; Altmann, M.; Andrae, R.; Antoja, T.; Audard, M.; Babusiaux, C.; Bailer-Jones, C. A. L.; Barache, C.; Bastian, U.; Beck, M.; Berthier, J.; Bianchi, L.; Biermann, M.; Bombrun, A.; Bossini, D.; Breddels, M.; Brown, A. G. A.; Busonero, D.; Butkevich, A.; Cantat-Gaudin, T.; Carrasco, J. M.; Cheek, N.; Clementini, G.; Creevey, O.; Crowley, C.; David, M.; Davidson, M.; De Angeli, F.; De Ridder, J.; Delbò, M.; Dell'Oro, A.; Diakité, S.; Distefano, E.; Drimmel, R.; Durán, J.; Evans, D. W.; Fabricius, C.; Fabrizio, M.; Fernández-Hernández, J.; Findeisen, K.; Fleitas, J.; Fouesneau, M.; Galluccio, L.; Gracia-Abril, G.; Guerra, R.; Gutiérrez-Sánchez, R.; Helmi, A.; Hernandez, J.; Holl, B.; Hutton, A.; Jean-Antoine-Piccolo, A.; Jevardat de Fombelle, G.; Joliet, E.; Jordi, C.; Juhász, Á.; Klioner, S.; Löffler, W.; Lammers, U.; Lanzafame, A.; Lebzelter, T.; Leclerc, N.; Lecoeur-Taïbi, I.; Lindegren, L.; Marinoni, S.; Marrese, P. M.; Mary, N.; Massari, D.; Messineo, R.; Michalik, D.; Mignard, F.; Molinaro, R.; Molnár, L.; Montegriffo, P.; Mora, A.; Mowlavi, N.; Muinonen, K.; Muraveva, T.; Nienartowicz, K.; Ordenovic, C.; Pancino, E.; Panem, C.; Pauwels, T.; Petit, J.; Plachy, E.; Portell, J.; Racero, E.; Regibo, S.; Reylé, C.; Rimoldini, L.; Ripepi, V.; Riva, A.; Robichon, N.; Robin, A.; Roelens, M.; Romero-Gómez, M.; Sarro, L.; Seabroke, G.; Segovia, J. C.; Siddiqui, H.; Smart, R.; Smith, K.; Sordo, R.; Soria, S.; Spoto, F.; Stephenson, C.; Turon, C.; Vallenari, A.; Veljanoski, J.; Voutsinas, S.

    2018-04-01

    The second Gaia data release, Gaia DR2, encompasses astrometry, photometry, radial velocities, astrophysical parameters (stellar effective temperature, extinction, reddening, radius, and luminosity), and variability information plus astrometry and photometry for a sample of pre-selected bodies in the solar system. The data collected during the first 22 months of the nominal, five-year mission have been processed by the Gaia Data Processing and Analysis Consortium (DPAC), resulting into this second data release. A summary of the release properties is provided in Gaia Collaboration et al. (2018b). The overall scientific validation of the data is described in Arenou et al. (2018). Background information on the mission and the spacecraft can be found in Gaia Collaboration et al. (2016), with a more detailed presentation of the Radial Velocity Spectrometer (RVS) in Cropper et al. (2018). In addition, Gaia DR2 is accompanied by various, dedicated papers that describe the processing and validation of the various data products. Four more Gaia Collaboration papers present a glimpse of the scientific richness of the data. In addition to this set of refereed publications, this documentation provides a detailed, complete overview of the processing and validation of the Gaia DR2 data. Gaia data, from both Gaia DR1 and Gaia DR2, can be retrieved from the Gaia archive, which is accessible from https://archives.esac.esa.int/gaia. The archive also provides various tutorials on data access and data queries plus an integrated data model (i.e., description of the various fields in the data tables). In addition, Luri et al. (2018) provide concrete advice on how to deal with Gaia astrometry, with recommendations on how best to estimate distances from parallaxes. The Gaia archive features an enhanced visualisation service which can be used for quick initial explorations of the entire Gaia DR2 data set. Pre-computed cross matches between Gaia DR2 and a selected set of large surveys are

  17. Modulation of TRAIL resistance in colon carcinoma cells: Different contributions of DR4 and DR5

    International Nuclear Information System (INIS)

    Geelen, Caroline MM van; Pennarun, Bodvael; Le, Phuong TK; Vries, Elisabeth GE de; Jong, Steven de

    2011-01-01

    rhTRAIL is a therapeutic agent, derived from the TRAIL cytokine, which induces apoptosis in cancer cells by activating the membrane death receptors 4 and 5 (DR4 and DR5). Here, we investigated each receptor's contribution to rhTRAIL sensitivity and rhTRAIL resistance. We assessed whether agonistic DR4 or DR5 antibodies could be used to circumvent rhTRAIL resistance, alone or in combination with various chemotherapies. Our study was performed in an isogenic model comprised of the SW948 human colon carcinoma cell line and its rhTRAIL resistant sub-line SW948-TR. Effects of rhTRAIL and agonistic DR4/DR5 antibodies on cell viability were measured using MTT assays and identification of morphological changes characteristic of apoptosis, after acridine orange staining. Sensitivity to the different death receptor ligands was stimulated using pretreatment with the cytokine IFN-gamma and the proteasome inhibitor MG-132. To investigate the mechanisms underlying the changes in rhTRAIL sensitivity, alterations in expression levels of targets of interest were measured by Western blot analysis. Co-immunoprecipitation was used to determine the composition of the death-inducing signalling complex at the cell membrane. SW948 cells were sensitive to all three of the DR-targeting agents tested, although the agonistic DR5 antibody induced only weak caspase 8 cleavage and limited apoptosis. Surprisingly, agonistic DR4 and DR5 antibodies induced equivalent DISC formation and caspase 8 cleavage at the level of their individual receptors, suggesting impairment of further caspase 8 processing upon DR5 stimulation. SW948-TR cells were cross-resistant to all DR-targeting agents as a result of decreased caspase 8 expression levels. Caspase 8 protein expression was restored by MG-132 and IFN-gamma pretreatment, which also re-established sensitivity to rhTRAIL and agonistic DR4 antibody in SW948-TR. Surprisingly, MG-132 but not IFN-gamma could also increase DR5-mediated apoptosis in SW948

  18. Modulation of TRAIL resistance in colon carcinoma cells: Different contributions of DR4 and DR5

    Directory of Open Access Journals (Sweden)

    de Vries Elisabeth GE

    2011-01-01

    Full Text Available Abstract Background rhTRAIL is a therapeutic agent, derived from the TRAIL cytokine, which induces apoptosis in cancer cells by activating the membrane death receptors 4 and 5 (DR4 and DR5. Here, we investigated each receptor's contribution to rhTRAIL sensitivity and rhTRAIL resistance. We assessed whether agonistic DR4 or DR5 antibodies could be used to circumvent rhTRAIL resistance, alone or in combination with various chemotherapies. Methods Our study was performed in an isogenic model comprised of the SW948 human colon carcinoma cell line and its rhTRAIL resistant sub-line SW948-TR. Effects of rhTRAIL and agonistic DR4/DR5 antibodies on cell viability were measured using MTT assays and identification of morphological changes characteristic of apoptosis, after acridine orange staining. Sensitivity to the different death receptor ligands was stimulated using pretreatment with the cytokine IFN-gamma and the proteasome inhibitor MG-132. To investigate the mechanisms underlying the changes in rhTRAIL sensitivity, alterations in expression levels of targets of interest were measured by Western blot analysis. Co-immunoprecipitation was used to determine the composition of the death-inducing signalling complex at the cell membrane. Results SW948 cells were sensitive to all three of the DR-targeting agents tested, although the agonistic DR5 antibody induced only weak caspase 8 cleavage and limited apoptosis. Surprisingly, agonistic DR4 and DR5 antibodies induced equivalent DISC formation and caspase 8 cleavage at the level of their individual receptors, suggesting impairment of further caspase 8 processing upon DR5 stimulation. SW948-TR cells were cross-resistant to all DR-targeting agents as a result of decreased caspase 8 expression levels. Caspase 8 protein expression was restored by MG-132 and IFN-gamma pretreatment, which also re-established sensitivity to rhTRAIL and agonistic DR4 antibody in SW948-TR. Surprisingly, MG-132 but not IFN

  19. Dr. Wernher von Braun and Dr. Ernst Stuhlinger Sign Citizenship Certificates

    Science.gov (United States)

    1955-01-01

    The members of the Peenemuende team and their family members were awarded the United States citizenship on April 14, 1955. Pictured here is Dr. Ernst Stuhlinger (middle) and Dr. Wernher von Braun signing U.S. citizenship certificates. Martin Schilling is at left.

  20. BE-ing @Work: Wearables and Presence of Mind in the Workplace

    Science.gov (United States)

    Forbes Oste, Heidi

    2016-01-01

    Expectations and demands in the changing contemporary workplace are driven by emergent technologies. Ubiquitous in nature, they are designed to enhance human and organization potential. These technologies provide access to information and connection at all times. They are increasingly reliant on human relationships and connection. BE-ing one's…

  1. Electric generator overhaul of the Ing. Carlos Ramirez Ulloa hydroelectric. Central project conclusions; Rehabilitacion de los generadores de la central hidroelectrica Ing. Carlos Ramirez Ulloa. Conclusiones del proyecto

    Energy Technology Data Exchange (ETDEWEB)

    Campuzano Martinez, Ignacio Roberto; Gonzalez Vazquez, Alejandro Esteban; Robles Pimentel, Edgar Guillermo; Esparza Saucedo, Marcos; Garcia Martinez, Javier; Sanchez Flores, Ernesto; Martinez Romero, Jose Luis [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1999-12-31

    The Hydroelectric Ing. Carlos Ramirez Ulloa Power Central has three 200 MW electric generators. The Central initiated its commercial operation in 1985. The electric generators had design problems that were properly corrected in an overhaul program that was initiated in 1996, with Unit 2 electric generator and completed in 1998 with Unit 1 electric generator. This paper presents the relevant aspects of the experience accumulated in the project. [Espanol] La central hidroelectrica Ing. Carlos Ramirez Ulloa cuenta con tres generadores de 200 MW cada uno. La central inicio su operacion comercial en 1985. Los generadores tenian problemas de diseno que fueron debidamente corregidos en un programa de rehabilitacion que inicio en 1996, con el generador de la unidad 2, y culmino en 1998 con el generador de la unidad 1. En este articulo se presentan los aspectos relevantes de la experiencia acumulada en el proyecto.

  2. Electric generator overhaul of the Ing. Carlos Ramirez Ulloa hydroelectric. Central project conclusions; Rehabilitacion de los generadores de la central hidroelectrica Ing. Carlos Ramirez Ulloa. Conclusiones del proyecto

    Energy Technology Data Exchange (ETDEWEB)

    Campuzano Martinez, Ignacio Roberto; Gonzalez Vazquez, Alejandro Esteban; Robles Pimentel, Edgar Guillermo; Esparza Saucedo, Marcos; Garcia Martinez, Javier; Sanchez Flores, Ernesto; Martinez Romero, Jose Luis [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1998-12-31

    The Hydroelectric Ing. Carlos Ramirez Ulloa Power Central has three 200 MW electric generators. The Central initiated its commercial operation in 1985. The electric generators had design problems that were properly corrected in an overhaul program that was initiated in 1996, with Unit 2 electric generator and completed in 1998 with Unit 1 electric generator. This paper presents the relevant aspects of the experience accumulated in the project. [Espanol] La central hidroelectrica Ing. Carlos Ramirez Ulloa cuenta con tres generadores de 200 MW cada uno. La central inicio su operacion comercial en 1985. Los generadores tenian problemas de diseno que fueron debidamente corregidos en un programa de rehabilitacion que inicio en 1996, con el generador de la unidad 2, y culmino en 1998 con el generador de la unidad 1. En este articulo se presentan los aspectos relevantes de la experiencia acumulada en el proyecto.

  3. An occurrence of approx. 74 ka Youngest Toba tephra from the western continental margin of India

    Digital Repository Service at National Institute of Oceanography (India)

    Pattan, J.N.; Shane, P.; Pearce, N.J.G.; Banakar, V.K.; Parthiban, G.

    . Navalgund and Dr M. S. Narayanan du r- ing the course of this work. Useful discussions with Dr P. S. Desai and Dr A. Sarkar are also thankfully acknow l edged. Received 28 July 2000; revised accepted 3 January 2001 An occurrence of ~ 7 4 ka.... The occurrence of Y TT in the west, north - west, south - west and recently north - east in the South China Sea Basin 17 , suggests wind direction du r ing YTT was not in one way. YTT occurred between oxygen isotope stage 5a and 4, a period of ice growth...

  4. Dr Math at your service

    CSIR Research Space (South Africa)

    Butgereit, L

    2012-10-01

    Full Text Available In this presentation the author explains how the Dr Math service works; how tutors are recruited to act as Dr Math; and how school pupils can reach Dr Math for help with their mathematics homework....

  5. Drømmejobbet

    DEFF Research Database (Denmark)

    Harrebye, Silas

    2012-01-01

    Medarbejdere vil i fremtiden også kunne arbejde, mens de sover. Virksomheder tilbyder snart deres ansatte interne kurser i ‘lucid dreaming’. Disse giver mulighed for, at man i sine drømme bliver bevidst om, at man drømmer og således kan manipulere dem. Det skal nu udnyttes. Management...

  6. Large Customers (DR Sellers)

    Energy Technology Data Exchange (ETDEWEB)

    Kiliccot, Sila [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2011-10-25

    State of the large customers for demand response integration of solar and wind into electric grid; openADR; CAISO; DR as a pseudo generation; commercial and industrial DR strategies; California regulations

  7. Inges Kindlustus kukkus kahjumisse. Kindlustushindade alandamata jätmine viis miinusesse / Kadrin Karner

    Index Scriptorium Estoniae

    Karner, Kadrin

    2011-01-01

    Inges Kindlustuse kahjumi põhjustas kõrgema hinnataseme säilitamine ning juhatuse liikmele välja makstud märkimisväärne tasu. Konkurentide RSA Kindlustus, Ergo Kindlustuse AS ja IF Kindlustus majandustulemused

  8. Loïc Brémaud, Catherine Guillaumin, L'archipel de l'ingénierie de la formation. Transformations, recompositions

    OpenAIRE

    Wahl, Elodie

    2011-01-01

    L'ouvrage L'archipel de l'ingénierie de la formation est la publication des actes d'un colloque qui s'est tenu à l'Université de Rennes 2 en janvier 2009. Le colloque comptait 22 intervenants, l'ouvrage est conséquent, et les articles sont très variés, tant par les perspectives adoptées, que par leurs formes ou leurs contenus. L'ouvrage se divise en trois grandes parties : la première traite de l'évolution de l'ingénierie de la formation, la seconde des nouvelles pratiques d'ingénierie, et la...

  9. BRÉMAUD Loïc & GUILLAUMIN Catherine (dir.). L’archipel de l’ingénierie de formation. Transformations, recompositions

    OpenAIRE

    Lavielle-Gutnik, Nathalie

    2011-01-01

    Cet ouvrage fait suite à un colloque éponyme associant les universités de Rennes 2, Tours et Nantes célébrant les vingt ans du Master SIFA (Stratégie et ingénierie en formation d’adultes). Le projet intellectuel que nourrit cet ouvrage est de reconsidérer les évolutions actuelles du champ de l’ingénierie de la formation. Son intérêt est moins d’identifier les pratiques d’ingénierie de formation, ce qu’il permet toutefois clairement de réaliser, que d’engager un véritable travail de modélisati...

  10. Prava trećih država u gospodarskom pojasu obalne države

    Directory of Open Access Journals (Sweden)

    Marina Vokić Žužul

    2003-12-01

    Full Text Available Predmet ovoga rada je analiza prava koja u gospodarskom pojasu obalne države mogu ostvarivati sve obalne i neobalne države. uz detaljan prikaz pravnog uređenja materije u odredbama Konvencije o pravu mora iz 1982., razmatraju se i vladajuća gledišta međunarodnopravne doktrine te rješenja u zakonodavstvima pojedinih zemalja. Posebna pozornost je posvećena ostvarivanju tuh prava u potencijalnom hrvatskom gospodarskom pojasu, prvenstveno mogućim zahtjevima od strane susjednih neobalnih država i država u nepovoljnom geografskom položaju. Sva pitanja razmatrana u ovom radu upućuju na zaključak da ispunjavanje dužnosti prema drugim državama u budućem gospodarskom pojasu RH ne bi trebalo imati utjecaja na donošenje odluke o njegovom proglašenju.

  11. On Mathematicians' Proof Skimming: A Reply to Inglis and Alcock

    Science.gov (United States)

    Weber, Keith; Mejia-Ramos, Juan Pablo

    2013-01-01

    n a recent article, Inglis and Alcock (2012) contended that their data challenge the claim that when mathematicians validate proofs, they initially skim a proof to grasp its main idea before reading individual parts of the proof more carefully. This result is based on the fact that when mathematicians read proofs in their study, on average their…

  12. N-methyl-N-nitro-N-nitrosoguanidine-mediated ING4 downregulation contributed to the angiogenesis of transformed human gastric epithelial cells.

    Science.gov (United States)

    Chen, Yansu; Fu, Rui; Xu, Mengdie; Huang, Yefei; Sun, Guixiang; Xu, Lichun

    2018-04-15

    Angiogenesis is associated with the progression and mortality of gastric cancer. Epidemiological evidences indicate that long-term N-nitroso compounds (NOCs) exposure predominantly contributes to the mortality of gastric cancer. Therefore, further reduced mortality of gastric cancer demands to explore the exact mechanisms of NOCs induced angiogenesis. As a tumor suppressor gene, inhibitor of growth protein 4 (ING4) plays an important role in pathological angiogenesis. In this study, we will investigate ING4 expression level in human gastric epithelial cells after the long-term low dose exposure of N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and the pathological impact of MNNG-reduced ING4 on angiogenesis of transformed cells. The soft agar colony formation assay, Western blotting, immunofluorescence and wound healing assay were used to evaluate the characteristics of transformed cells. HUVEC growth and tube formation assays were performed to test the angiogenic abilities. EMSA, luciferase reporter gene assay, real-time PCR and Western blotting were used to explore the exact mechanism. By establishing transformed human gastric epithelial cells via chronic low dose treatment, a gradually ING4 downregulation was observed in the later-stage of MNNG-induced cell transformation. Moreover, we demonstrated that MNNG exposure-reduced ING4 expression significantly resulted into aggravating angiogenesis through increasing the phosphorylation level of NF-κB p65 and subsequently DAN binding activity and regulating the expressions of NF-κB p65 downstream pro-angiogenic genes, MMP-2 and MMP-9. Our findings provided a significant mechanistic insight into angiogenesis of MNNG-transformed human gastric epithelial cell and supported the concept that ING4 may be a relevant therapeutic target for gastric cancer. Copyright © 2018 Elsevier Inc. All rights reserved.

  13. VIP visit of LHC Computing Grid Project

    CERN Multimedia

    Krajewski, Yann Tadeusz

    2015-01-01

    VIP visit of LHC Computing Grid Project with Dr -.Ing. Tarek Kamel [Senior Advisor to the President for Government Engagement, ICANN Geneva Office] and Dr Nigel Hickson [VP, IGO Engagement, ICANN Geneva Office

  14. In vivo statistical evaluation of efficancy of a biological agent on water quality in the rearing of ornamental Cyprinus carpio

    CSIR Research Space (South Africa)

    Ramduth, DM

    2006-02-01

    Full Text Available ponds. ACKNOWLEDGEMENTS The authors would like to express their gratitude to: Dr Horst Kaizer, Dr Santosh Ramchuran and Dr Naill Vine for their valuable inputs dur- ing the trial and BioPad BRIC for their generous funding of the project. • • Figure...

  15. Enrico Fermi Awards Ceremony for Dr. Mildred S. Dresselhaus and Dr. Burton Richter, May 2012 (Presentations, including remarks by Energy Secretary, Dr. Steven Chu)

    International Nuclear Information System (INIS)

    Chu, Steven

    2012-01-01

    The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On May 7, 2012 it was conferred upon two exceptional scientists: Dr. Mildred Dresselhaus, 'for her scientific leadership, her major contributions to science and energy policy, her selfless work in science education and the advancement of diversity in the scientific workplace, and her highly original and impactful research,' and Dr. Burton Richter, 'for the breadth of his influence in the multiple disciplines of accelerator physics and particle physics, his profound scientific discoveries, his visionary leadership as SLAC Director, his leadership of science, and his notable contributions in energy and public policy.' Dr. John Holder, Director of the White House Office of Science and Technology Policy, opened the ceremony, and Dr. Bill Brinkman, Director of DOE's Office of Science introduced the main speaker, Dr. Steven Chu, U.S. Energy Secretary.

  16. A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons.

    Science.gov (United States)

    Leighton, Laura J; Zhao, Qiongyi; Li, Xiang; Dai, Chuanyang; Marshall, Paul R; Liu, Sha; Wang, Yi; Zajaczkowski, Esmi L; Khandelwal, Nitin; Kumar, Arvind; Bredy, Timothy W; Wei, Wei

    2018-01-15

    Epigenetic regulation of activity-induced gene expression involves multiple levels of molecular interaction, including histone and DNA modifications, as well as mechanisms of DNA repair. Here we demonstrate that the genome-wide deposition of inhibitor of growth family member 1 (ING1), which is a central epigenetic regulatory protein, is dynamically regulated in response to activity in primary cortical neurons. ING1 knockdown leads to decreased expression of genes related to synaptic plasticity, including the regulatory subunit of calcineurin, Ppp3r1. In addition, ING1 binding at a site upstream of the transcription start site (TSS) of Ppp3r1 depends on yet another group of neuroepigenetic regulatory proteins, the Piwi-like family, which are also involved in DNA repair. These findings provide new insight into a novel mode of activity-induced gene expression, which involves the interaction between different epigenetic regulatory mechanisms traditionally associated with gene repression and DNA repair. Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

  17. In Memoriam: Dr. Frank John Fenner

    Centers for Disease Control (CDC) Podcasts

    This podcast reflects on one of the greatest pioneers in virology, Dr. Frank John Fenner. Dr. Frederick Murphy, a member of EID's editorial board and the Institute of Medicine, and professor of Pathology at the University of Texas Medical Branch in Galveston, shares professional and personal stories of Dr. Frank Fenner.

  18. Forum-ing: Signature practice for public theological discourse

    Directory of Open Access Journals (Sweden)

    Edward P. Wimberly

    2014-05-01

    Full Text Available This article introduces a unique model for public theological conversation and discourse, which was developed by the Concerned Black Clergy of Atlanta (CBC. It was a model developed in response to the problems of poverty, homelessness, and the ‘missing and murdered children’ victimised in Atlanta, Georgia in the United States of America in the early 1980s. It was originally organised to respond to the economic, financial, spiritual, emotional, employment, housing and resource needs of the underserved poor. This unique practice is called forum-ing. The forum meets every Monday morning, except when there is a national holiday. It has operated 30 consecutive years. The forum has a series of presentations, including the opening prayer, self-introductions of each person, a report of the executive director, special presentations from selected community groups, reports, and then questions and answers. The end result is that those attending engage in a process of discourse that enables them to internalise new ideas, approaches, and activities for addressing poverty and injustice in the community. Key to forum-ing for the 21st century is that it is a form of public practical theology rooted and grounded in non-violence growing out of the civil rights movement of the 1950s and 1960s in the United States. The overall purpose of this article is to contribute to the effort of the Faculty of Theology at the University of Pretoria (South Africa to identify those variables that will assist religious leaders in South Africa to develop public conversational spaces to enhance democratic participation. This article presents one model from the African American community in Atlanta, Georgia. The hope is to lift up key variables that might assist in the practical and pastoral theological conversation taking place in South Africa at present.

  19. Modèles de gestion des ressources forestières du massif ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ingénieurs. Institution Country. Maroc. Institution Website. http://www.enfi.ac.ma. Project Leader. Dr. Mohamed Khemici. Institution. Institut national de la recherche forestière. Institution Country. Algérie. Project Leader. Dr. Abdelhamid Khaldi ...

  20. ExNum 2016 International Symposium on Experimental Methods and Numerical Simulation in Engineering Sciences

    Directory of Open Access Journals (Sweden)

    Editorial Foreword

    2016-12-01

    Full Text Available ExNum 2016International Symposium on Experimental Methods and Numerical Simulation in Engineering SciencesSeptember 18th - 21st, 2016Conference Centre Liblice, Liblice, Czech RepublicOrganized by:Institute of Theoretical and Applied Mechanics ASCR, v.v.i.Faculty of Transportation Sciences CTU in PragueBergische Universität Wuppertal, Faculty 5 - Architecture and Civil EngineeringThe International Symposium on Experimental Methods and Numerical Simulation in Engineering Sciences continues the tradition of the Czech-German bilateral symposium founded by prof. Karl-Hans Laermann and prof. Stanislav Holý in 1985. In the following years, the symposium was extensively developed by prof. Josef Jíra. The symposium shall bring together mainly young scientists who are actively involved in experimental solid mechanics, theoretically and practically, in order to exchange experience, to report on the present state-of-art as well as on running research projects, to discuss due questions and problems and to promote the co-operation between individuals as well as between institutions. Therefore in the symposium discussions will play a highly significant role.Scientific Committeeprof. Ing. Ondřej Jiroušek, Ph.D. (Institute of Theoretical and Applied Mechanics ASCR, v.v.i.Univ.-Prof. Dr.-Ing.Dr.h.c.mult. Karl-Hans Laermann (Bergische Universität WuppertalProf. Dr.- Ing. Reinhard Harte (Bergische Universität Wuppertal, Faculty 5 - Architecture and Civil EngineeringProf. Dr.-Ing. Marc Gutermann (Hochschule BremenIng. Daniel Kytýř, Ph.D. (Czech Technical University in Prague, Faculty of Transportation SciencesIng. Petr Zlámal, Ph.D. (Institute of Theoretical and Applied Mechanics ASCR, v.v.i.Local Organizing CommitteeTomáš DoktorTomáš FílaNela KrčmářováPetr KoudelkaVeronika KoudelkováDaniel KytýřJan ŠleichrtPetr ZlámalEditorsDaniel KytýřPetr ZlámalScientific GuidanceOndřej Jiroušek

  1. 95 GHz methanol masers near DR 21 and DR 21(OH)

    International Nuclear Information System (INIS)

    Plambeck, R.L.; Menten, K.M.

    1990-01-01

    The BIMA array is used to map the 95-GHz 8(0) to 7 1A(+) transition of methanol and the 98-GHz J = 2-1 transition of CS toward the DR 21(OH) and DR 21 star-forming regions. Several strong methanol masers were found. The positions of the two brightest masers were measured with an accuracy of about + or - 0.3 arcsec. Toward DR 21(OH), the positions, velocities, and line shapes of the 95 GHz masers are in excellent agreement with those of the 84-GHz 5(-1) to 4 () methanol masers previously mapped by Batrla and Menten (1988), demonstrating that maser emission in both transitions originates from the same clumps of gas. The methanol masers are offset from CS emission peaks and from other known infrared and maser sources; they may possibly be clustered along the interface between outflows, traced by shock-excited H2 emission, and dense ambient gas, traced by CS emission. 25 refs

  2. Dr Stanislaw Huskowski, Mayor of Wroclaw, Poland

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Dr Stanislaw Huskowski, Mayor of Wroclaw, Poland visiting the ATLAS magnet assembly hall, building 180 with Mr Carlo Lamprecht, State Councillor, Dr Stanislaw Huskowski and Dr Peter Jenni, ATLAS Spokesperson

  3. Dr Stanislaw Huskowski, Mayor of Wroclaw, Poland

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Dr Stanislaw Huskowski, Mayor of Wroclaw, Poland visiting the ATLAS magnet assembly hall, building 180. From l to r: Mr Carlo Lamprecht, State Councillor, Dr Stanislaw Huskowski and Dr Peter Jenni, ATLAS Spokesperson

  4. Finanční analýza podniku Ing. Bronislav Vala

    OpenAIRE

    Valová, Anežka

    2013-01-01

    Aim of this work is to evaluate the financial performance of the company Ing. Bronislav Vala based on financial analysis from 2008 to 2012. The applied methods od financial analysis are selected for this evaluation. The used methods include vertical and horizontal analysis, analysis of ratios, analysis of differential indicators, pyramidal decomposition Du Pont, value and bankruptcy models and inter-company comparisons. The thesis is divided into theoretical and practical parts. The theoretic...

  5. L’ingénierie pédagogique à base d’objets et le référencement par les compétences

    Directory of Open Access Journals (Sweden)

    Gilbert Paquette

    2004-01-01

    Full Text Available Nous situons l’ingénierie pédagogique au confluent du design pédagogique, du génie logiciel et de l’ingénierie cognitive. Puis, dans l’optique d’une ingénierie pédagogique à base d’objets, nous proposons une méthode permettant de représenter graphiquement les connaissances et les compétences, puis de les associer aux ressources d’apprentissage. Par la suite, nous montrons comment cette méthode peut contribuer à améliorer la qualité des environnements en ligne à chacune des phases de leur cycle de vie.

  6. Dr Pugh: a poisoner?

    Science.gov (United States)

    Paull, J D; Morris, G M

    2012-07-01

    On 16 February 1845 the Reverend W. H. Browne, rector of St John's Church in Launceston, Van Diemen's Land, wrote in his journal, "My dear Wife died very suddenly almost immediately after and in consequence of taking a preparation of Hyd. Cyan. Acid prepared & supplied by Dr Pugh". This journal entry raises a number of questions. Was Dr Pugh treating a condition which he thought merited that treatment or was it a ghastly mistake? Was Caroline Browne suffering from pulmonary tuberculosis? Was hydrocyanic acid an accepted treatment at that time? Did Mrs Browne take the wrong dose? Was an incorrect concentration of the drug prepared by Dr Pugh? Did he use the wrong pharmacopoeia in preparing the hydrocyanic acid? Why was there no inquest? Only some of these questions can be answered.

  7. LoopIng: a template-based tool for predicting the structure of protein loops.

    KAUST Repository

    Messih, Mario Abdel

    2015-08-06

    Predicting the structure of protein loops is very challenging, mainly because they are not necessarily subject to strong evolutionary pressure. This implies that, unlike the rest of the protein, standard homology modeling techniques are not very effective in modeling their structure. However, loops are often involved in protein function, hence inferring their structure is important for predicting protein structure as well as function.We describe a method, LoopIng, based on the Random Forest automated learning technique, which, given a target loop, selects a structural template for it from a database of loop candidates. Compared to the most recently available methods, LoopIng is able to achieve similar accuracy for short loops (4-10 residues) and significant enhancements for long loops (11-20 residues). The quality of the predictions is robust to errors that unavoidably affect the stem regions when these are modeled. The method returns a confidence score for the predicted template loops and has the advantage of being very fast (on average: 1 min/loop).www.biocomputing.it/loopinganna.tramontano@uniroma1.itSupplementary data are available at Bioinformatics online.

  8. Pathogenesis of Human Diffusely Adhering Escherichia coli Expressing Afa/Dr Adhesins (Afa/Dr DAEC): Current Insights and Future Challenges

    Science.gov (United States)

    2014-01-01

    SUMMARY The pathogenicity and clinical pertinence of diffusely adhering Escherichia coli expressing the Afa/Dr adhesins (Afa/Dr DAEC) in urinary tract infections (UTIs) and pregnancy complications are well established. In contrast, the implication of intestinal Afa/Dr DAEC in diarrhea is still under debate. These strains are age dependently involved in diarrhea in children, are apparently not involved in diarrhea in adults, and can also be asymptomatic intestinal microbiota strains in children and adult. This comprehensive review analyzes the epidemiology and diagnosis and highlights recent progress which has improved the understanding of Afa/Dr DAEC pathogenesis. Here, I summarize the roles of Afa/Dr DAEC virulence factors, including Afa/Dr adhesins, flagella, Sat toxin, and pks island products, in the development of specific mechanisms of pathogenicity. In intestinal epithelial polarized cells, the Afa/Dr adhesins trigger cell membrane receptor clustering and activation of the linked cell signaling pathways, promote structural and functional cell lesions and injuries in intestinal barrier, induce proinflammatory responses, create angiogenesis, instigate epithelial-mesenchymal transition-like events, and lead to pks-dependent DNA damage. UTI-associated Afa/Dr DAEC strains, following adhesin-membrane receptor cell interactions and activation of associated lipid raft-dependent cell signaling pathways, internalize in a microtubule-dependent manner within urinary tract epithelial cells, develop a particular intracellular lifestyle, and trigger a toxin-dependent cell detachment. In response to Afa/Dr DAEC infection, the host epithelial cells generate antibacterial defense responses. Finally, I discuss a hypothetical role of intestinal Afa/Dr DAEC strains that can act as “silent pathogens” with the capacity to emerge as “pathobionts” for the development of inflammatory bowel disease and intestinal carcinogenesis. PMID:25278576

  9. From Mxit to Dr Math

    CSIR Research Space (South Africa)

    Botha, Adèle

    2013-02-01

    Full Text Available In 2007, Laurie Butgereit, a researcher at the CSIR Meraka Institute, started to use Mxit as a communication channel to tutor her son in mathematics. Her son and a number of his friends logged in, and Dr Math was born. At the inception of Dr Math...

  10. Impact of pEGFP mediated ING4 gene on growth of glioma U251 ...

    African Journals Online (AJOL)

    Jane

    2011-06-22

    Jun 22, 2011 ... Full Length Research Paper. Impact of pEGFP mediated ING4 gene on growth of glioma U251 cells and its potential molecular mechanism. Yuefei Deng*, Bingxi Lei and Yiying Zhao. Department of Neurosurgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.

  11. Pathogenesis of human diffusely adhering Escherichia coli expressing Afa/Dr adhesins (Afa/Dr DAEC): current insights and future challenges.

    Science.gov (United States)

    Servin, Alain L

    2014-10-01

    The pathogenicity and clinical pertinence of diffusely adhering Escherichia coli expressing the Afa/Dr adhesins (Afa/Dr DAEC) in urinary tract infections (UTIs) and pregnancy complications are well established. In contrast, the implication of intestinal Afa/Dr DAEC in diarrhea is still under debate. These strains are age dependently involved in diarrhea in children, are apparently not involved in diarrhea in adults, and can also be asymptomatic intestinal microbiota strains in children and adult. This comprehensive review analyzes the epidemiology and diagnosis and highlights recent progress which has improved the understanding of Afa/Dr DAEC pathogenesis. Here, I summarize the roles of Afa/Dr DAEC virulence factors, including Afa/Dr adhesins, flagella, Sat toxin, and pks island products, in the development of specific mechanisms of pathogenicity. In intestinal epithelial polarized cells, the Afa/Dr adhesins trigger cell membrane receptor clustering and activation of the linked cell signaling pathways, promote structural and functional cell lesions and injuries in intestinal barrier, induce proinflammatory responses, create angiogenesis, instigate epithelial-mesenchymal transition-like events, and lead to pks-dependent DNA damage. UTI-associated Afa/Dr DAEC strains, following adhesin-membrane receptor cell interactions and activation of associated lipid raft-dependent cell signaling pathways, internalize in a microtubule-dependent manner within urinary tract epithelial cells, develop a particular intracellular lifestyle, and trigger a toxin-dependent cell detachment. In response to Afa/Dr DAEC infection, the host epithelial cells generate antibacterial defense responses. Finally, I discuss a hypothetical role of intestinal Afa/Dr DAEC strains that can act as "silent pathogens" with the capacity to emerge as "pathobionts" for the development of inflammatory bowel disease and intestinal carcinogenesis. Copyright © 2014, American Society for Microbiology. All Rights

  12. In Memoriam: Dr. Frank John Fenner

    Centers for Disease Control (CDC) Podcasts

    2011-04-22

    This podcast reflects on one of the greatest pioneers in virology, Dr. Frank John Fenner. Dr. Frederick Murphy, a member of EID's editorial board and the Institute of Medicine, and professor of Pathology at the University of Texas Medical Branch in Galveston, shares professional and personal stories of Dr. Frank Fenner.  Created: 4/22/2011 by National Center for Emerging Zoonotic and Infectious Diseases (NCEZID).   Date Released: 4/26/2011.

  13. Dr. von Braun Briefing Walt Disney

    Science.gov (United States)

    1965-01-01

    Dr. von Braun began his association with Walt Disney in the 1950s when the rocket scientist appeared in three Disney television productions related to the exploration of space. Years later, Dr. von Braun invited Disney and his associates to tour the Marshall Space Flight Center (MSFC) in Huntsville, Alabama. This photograph is dated April 13, 1965. From left are R.J. Schwinghamer from the MSFC, Disney, B.J. Bernight, and Dr. von Braun.

  14. Complex Strategic Choices

    DEFF Research Database (Denmark)

    Leleur, Steen

    to strategic decision making, Complex Strategic Choices presents a methodology which is further illustrated by a number of case studies and example applications. Dr. Techn. Steen Leleur has adapted previously established research based on feedback and input from various conferences, journals and students...... resulting in new material stemming from and focusing on practical application of a systemic approach. The outcome is a coherent and flexible approach named systemic planning. The inclusion of both the theoretical and practical aspects of systemic planning makes this book a key resource for researchers...

  15. Collaborative work between the West and Asia.

    Science.gov (United States)

    Hser, Yih-Ing; Bart, Gavin; Li, Li; Giang, Le Minh

    2013-12-01

    The "Collaborative Work between the West and Asia" session was chaired by Dr. Yih-Ing Hser and had three speakers. The speakers (and their topics) were: Dr. Gavin Bart (Collaborative Addiction Research in Asian Populations Home and Abroad), Dr. Li Li (Implementing Intervention Research Projects in Asia), and Dr. Le Minh Giang (Building Research Infrastructure for International Collaborative Studies on Substance Use Disorder and HIV: The Case of Hanoi Medical University/Vietnam).

  16. Modulation of TRAIL resistance in colon carcinoma cells : Different contributions of DR4 and DR5

    NARCIS (Netherlands)

    van Geelen, Caroline M. M.; Pennarun, Bodvael; Le, Phuong T. K.; de Vries, Elisabeth G. E.; de Jong, Steven

    2011-01-01

    Background: rhTRAIL is a therapeutic agent, derived from the TRAIL cytokine, which induces apoptosis in cancer cells by activating the membrane death receptors 4 and 5 (DR4 and DR5). Here, we investigated each receptor's contribution to rhTRAIL sensitivity and rhTRAIL resistance. We assessed whether

  17. Analysis of DR4 haplotypes in insulin dependent diabetes (IDD)

    International Nuclear Information System (INIS)

    Monos, D.S.; Radka, S.F.; Zmijewski, C.M.; Kamoun, M.

    1986-01-01

    Population studies indicate that HLA-DR4 is implicated in the susceptibility of IDD. However, biochemical characterization of the serologically defined DR4 haplotype from normal individuals revealed five DR4 and three DQW3 molecular forms. Hence, in this study, they investigated the heterogeneity of the DR4 haplotype, using B-lymphoblastoid cell lines (B-LCL) generated from patients with IDD and seropositive for DR4. Class II molecules, metabolically labeled with 35 S-methionine, were immunoprecipitated with monoclonal antibodies specific for DR(L243), DQ(N297), DQW3(IVD12) or DR and DQ(SG465) and analyzed by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). The isoelectrofocusing (IEF) conditions employed in this study allow representation only of the DR4 haplotype from either DR3/4 or DR4/4 cell lines. The analysis of six different DR4 haplotypes from seven IDD patients, revealed the presence of two DR4 β and two DQW3 β chains. Three of the six DR4 β haplotypes analyzed shared the same DR4 β chain and three others shared a different one. Additionally five of the six haplotypes shared a different one. Additionally five of the six haplotypes shared the same DQW3 β chain and only one was carrying a different one. Different combinations of the two DR4 and two DQW3 β chains constitute three distinct patterns of DR4 haplotypes. These results suggest the prevalence of a DQW3 β chain in the small sample of IDD patients studied. Studies of a large number of patients should clarify whether IDD is associated with unique variants of DR4 or DQW3 β chains

  18. Dr. von Braun and Dr. Stuhlinger With a Model of the Nuclear-Electric Vehicles

    Science.gov (United States)

    2004-01-01

    In this photo, taken at the Walt Disney Studios in California, Dr. Wernher von Braun and Dr. Ernst Stuhlinger are shown discussing the concepts of nuclear-electric spaceships designed to undertake the mission to the planet Mars. As a part of the Disney 'Tomorrowland' series on the exploration of space, the nuclear-electric vehicles were shown in the last three television films, entitled 'Mars and Beyond,' which first aired in December 1957.

  19. Dr. Yu Wang, Director, Natural Science Division, National Science Council, Taiwan

    CERN Document Server

    Patrice Loïez

    2001-01-01

    Photo 01: L. to r.: Dr. Philippe Bloch, CERN CMS ECAL Deputy Project Manager, Dr. Yu Wang, Dr. Etiennette Auffray, CERN, responsible of the CERN ECAL Regional Centre. Photo 02: L. to r.: Dr. Yu Wang, Dr. Philippe Bloch, Dr. Apollo GO, National Central University, Taiwan, Dr. Etiennette Auffray.

  20. Dr. David Syz, State Secretary for Economic Affairs, Switzerland

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    Photo 01: Dr. David Syz (left) with Professor Roger Cashmore, Research Director for Collider Programmes.Photo 02: Dr. David Syz signing the VIP visitors' book, with Prof. Roger Cashmore.Photo 03: Dr. David Syz signing the VIP visitors' book.Photo 04: Handshake between Dr. David Syz (left) and Prof. Roger Cashmore.

  1. An Interview with Dr. Walter Lear

    Directory of Open Access Journals (Sweden)

    The Editors

    2009-03-01

    Full Text Available In this issue of the English version of Social Medicine we are publishing the first of several pamphlets loaned to us by the US Health Activism History Collection. To introduce this collection we travelled to Philadelphia on June 18, 2008 to interview Dr. Walter J. Lear. Dr Lear, born in 1923, is the person responsible for the collection. In a wide-ranging interview in his home Dr. Lear discussed his personal background, the origins and purpose of the collection, the impact of the McCarthy period on the US health left, as well as his vision for the future.

  2. HLA-DR expression and disease activity in ulcerative colitis

    DEFF Research Database (Denmark)

    Poulsen, L O; Elling, P; Sørensen, Flemming Brandt

    1986-01-01

    In 12 patients with active ulcerative colitis (UC) the rectal epithelial cells were analyzed for HLA-DR antigens by an immunohistochemical technique. The clinical, rectoscopic, and histologic stages were also determined. The investigations were carried out at the beginning of the study and 2 weeks...... and 3 months later. The rectal epithelial cells were HLA-DR-positive in all patients at the first two examinations. After 3 months five patients had changed to an HLA-DR-negative stage, whereas the other seven patients remained HLA-DR-positive. Closer analyses showed that expression/nonexpression of HLA-DR...... antigens on rectal epithelial cells of patients with UC could not be predicted from the clinical, rectoscopic, or histologic findings. HLA-DR expression is normally restricted to immunocompetent cells. The presence of HLA-DR antigens on epithelial cells may be a consequence of immunological reactions...

  3. HLA Dr beta 1 alleles in Pakistani patients with rheumatoid arthritis

    International Nuclear Information System (INIS)

    Naqi, N.; Ahmed, T.A.; Bashir, M.M.

    2011-01-01

    Objective: To determine frequencies of HLA DR beta 1 alleles in rheumatoid arthritis in Pakistani patients. Study Design: Cross sectional / analytical study. Place and Duration of Study: Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi in collaboration with Rheumatology departments of Military Hospital, Rawalpindi and Fauji Foundation Hospital, Rawalpindi, from January 2009 to January 2010. Methodology: HLA DR beta 1 genotyping of one hundred Pakistani patients, diagnosed as having RA as per American College of Rheumatology revised criteria 1987, was done. HLA DR beta 1 genotyping was carried out at allele group level (DR beta 1*01-DR beta 1*16) by sequence specific primers in RA patients. Comparison of HLA DR beta 1 allele frequencies between patients and control groups was made using Pearson's chi-square test to find possible association of HLA DR?1 alleles with RA in Pakistani rheumatoid patients. Results: HLA DR beta 1*04 was expressed with significantly increased frequency in patients with rheumatoid arthritis (p <0.05). HLA DR?1*11 was expressed statistically significantly more in control group as compared to rheumatoid patients indicating a possible protective effect. There was no statistically significant difference observed in frequencies of HLA DR beta 1 allele *01, DR beta 1 allele *03, DR beta 1 allele *07, DR beta 1 allele *08, DR beta 1 allele *09, DR beta 1 allele *10, DR beta 1 allele *12, DR beta 1 allele *13, DR beta 1 allele *14, DR?1 allele *15 and DR beta 1 allele *16 between patients and control groups. Conclusion: The identification of susceptible HLA DR beta 1 alleles in Pakistani RA patients may help physicians to make early decisions regarding initiation of early intensive therapy with disease modifying anti rheumatic medicines and biological agents decreasing disability in RA patients. (author)

  4. Algõpetuse peajoon ja harupedagoogikad / Sirje Piht, Elve Voltein, Anne Uusen, Inge Timoštšuk

    Index Scriptorium Estoniae

    2012-01-01

    Intervjuu Sirje Pihti ja Anne Uuseniga Tallinna Ülikooli algõpetuse osakonnast, Elve Volteiniga Tartu Ülikooli haridusteaduste instituudi õpetajate seminarist ja Inge Timoštšukiga Tallinna Ülikooli kasvatusteaduste instituudi pedagoogilise praktika keskusest

  5. FOREWORD: Dr Trevor J Hicks Dr Trevor J Hicks

    Science.gov (United States)

    Goossens, Darren

    2009-03-01

    This issue of Journal of Physics: Condensed Matter has been assembled to recognize the valuable contribution of Dr Trevor J Hicks to the field of neutron scattering and magnetism. Trevor began his study of magnetism as a PhD student at Monash University in Melbourne in the early 1960s, working with Professor Jack Smith. From the very beginning magnetism in alloys, and disordered systems in general, became a key aspect of his career. After a postdoctoral position at Harwell working with Dr Graeme Low Trevor returned to Australia and took up a position with Monash. He soon became a key figure in developing the capability for neutron scattering using the HIFAR reactor at the Australian Atomic Energy Commission, now the Australian Nuclear Science and Technology Organisation, ANSTO. The instrumentation was always developed to further his studies of magnetism. The development of polarization analysis measurements of diffuse magnetic scattering, first using iron filters and then his own design of supermirror benders for beam polarization, took place through the 1970s, 1980s and into the 1990s. Throughout this time, Trevor mentored a series of PhD students and postdoctoral fellows, many of whom have contributed to this issue (and, indeed, guest edited it). As befits a scientist and university academic for whom teaching has always been important, Trevor has not only created a strong body of significant research, he has also made a major contribution to preparing several generations of neutron scattering scientists, and this issue reflects that. When I approached Journal of Physics: Condensed Matter with a proposal for an issue in honour of Trevor, the response was immediate and positive. It is with great pleasure that I present the result of that proposal. The great diversity of the content, all centred on neutron scattering and magnetism, reflects the breadth of Trevor's own career and of the scientists with whom he has interacted. Finally, I would like to make some

  6. Comparaison du Srōš Drōn avec le Drōn Yašt

    OpenAIRE

    Redard, Céline

    2015-01-01

    This paper draws a parallel between two texts having the same textual base: The Srōš Drōn, derived from the Long Liturgy and the Drōn Yašt, belonging to the short liturgies. The goal is to establish the similarities and the discrepancies between these two texts. Peer reviewed

  7. Association of differentiated thyroid carcinoma with HLA-DR7

    International Nuclear Information System (INIS)

    Sridama, V.; Hara, Y.; Fauchet, R.; DeGroot, L.J.

    1985-01-01

    Seventy-four American white thyroid cancer patients were typed for HLA-A, B, and DR antigens. A significant increase in HLA-DR7 was found in the nonradiation-associated thyroid cancer patients (42.5%, 20/47 cases), compared to 22.8% of 979 normal controls. The association is stronger in the follicular and mixed papillary-follicular subgroup (52.0%, 13/25 cases, P corrected less than 0.01). The occurrence of various malignancies in family members was found in 57.9% of HLA-DR7 positive patients, versus 20% of HLA-DR7 negative patients, in a retrospective record review. Although the frequency of HLA-DR7 was not increased in the radiation-associated thyroid cancer patients (22.2%, 6/27 cases), the interval from the irradiation date to the onset date of thyroid cancer was shorter in HLA-DR7 positive cases (17.3 +/- 6.2 years) than in HLA-DR7 negative patients (29.4 +/- 11.5 years). This data suggest that HLA-DR7 is associated with and may influence development of thyroid cancer

  8. Dr. Martin Luther King, Jr. as Spiritual Leader

    Directory of Open Access Journals (Sweden)

    Andrea Pierce

    2013-09-01

    Full Text Available The purpose of this paper is to explore Dr. Martin Luther King Jr.’s spiritual leadership through his “I Have a Dream” speech. The paper explores the three characteristics of spiritual leadership as posed by Fry’s (2003 spiritual leadership theory: vision, hope/faith and altruistic love. The research draws upon these characteristics through qualitative content analysis of Dr. Martin Luther King Jr.’s “I Have a Dream” speech to illustrate Dr. King’s leadership as that of a spiritual leader. The research advances the spiritual leadership theory by establishing Dr. Martin Luther King Jr. as a spiritual leader. Through the illustration of Dr. King’s spiritual leadership, the characteristics of a spiritual leader are given tangible understanding.

  9. The DR-2 project

    DEFF Research Database (Denmark)

    Ølgaard, Povl Lebeck

    2003-01-01

    state of the reactor and to determine, which radionuclides remain where in the reactor in what amounts. The first part of the reactor to be investigated was the reactor tank. The lids at the reactor top wereremoved, air samples taken and smear test made in the tank. Then the control rods, the magnet....... At the start of the project the activity in DR-2 was about 45-50 GBq. Now it is about 5-10 GBq. Based on the results of the DR-2 project it is believed that the reactor can readily bedismantled and decommissioned....

  10. Tribute to Dr Jacques Rogge

    DEFF Research Database (Denmark)

    Bourgois, Jan G; Dumortier, Jasmien; Callewaert, Margot

    2017-01-01

    'A tribute to Dr J. Rogge' aims to systematically review muscle activity and muscle fatigue during sustained submaximal quasi-isometric knee extension exercise (hiking) related to Olympic dinghy sailing as a tribute to Dr Rogge's merits in the world of sports. Dr Jacques Rogge is not only...... of invasive needle electromyography (EMG) during a specific sailing technique (hiking) on a self-constructed sailing ergometer. Hiking is a bilateral and multi-joint submaximal quasi-isometric movement which dinghy sailors use to optimize boat speed and to prevent the boat from capsizing. Large stresses...... are generated in the anterior muscles that cross the knee and hip joint, mainly employing the quadriceps at an intensity of 30-40% maximal voluntary contraction (MVC), sometimes exceeding 100% MVC. Better sailing level is partially determined by a lower rate of neuromuscular fatigue during hiking and for ≈60...

  11. Human immune responsiveness to Lolium perenne pollen allergen Lol p III (rye III) is associated with HLA-DR3 and DR5.

    Science.gov (United States)

    Ansari, A A; Freidhoff, L R; Meyers, D A; Bias, W B; Marsh, D G

    1989-05-01

    A well-characterized allergen of Lolium perenne (perennial rye grass) pollen, Lol p III, has been used as a model antigen to study the genetic control of the human immune response. Associations between HLA type and IgE or IgG antibody (Ab) responsiveness to Lol p III were studied in two groups of skin-test-positive Caucasoid adults (N = 135 and 67). We found by nonparametric and parametric analyses that immune responsiveness to Lol p III was significantly associated with HLA-DR3 and DR5. No association was found between any DQ type and immune responsiveness to Lol p III. Geometric mean IgE or IgG Ab levels to Lol p III were not different between B8+, DR3+ subjects and B8-, DR3+ subjects, showing that HLA-B8 had no influence on the association. Lol p III IgG Ab data obtained on subjects after grass antigen immunotherapy showed that 100% of DR3 subjects and 100% of DR5 subjects were Ab+. A comparison of all the available protein sequences of DRB gene products showed that the first hypervariable region of DR3 and DR5 (and DRw6), and no other region, contains the sequence Glu9-Tyr-Ser-Thr-Ser13. Our observations are consistent with the possibility that immune responsiveness to the allergen Lol p III is associated with this amino acid sequence in the first hypervariable region of the DR beta 1 polypeptide chain.

  12. Superconducting properties of In-Ge mixture films

    International Nuclear Information System (INIS)

    Gerber, A.; Deutscher, G.

    1987-01-01

    We report on measurements of the perpendicular H/sub c//sub perpendicular/ and parallel H/sub c//sub X/ upper critical fields of superconducting In-Ge mixture films in a wide range of In concentrations. The resistivities of the samples varied from about 10 μΩX, corresponding to high In concentration, up to about 1300 μΩ cm, corresponding to an In concentration close to the percolation threshold of the system. The critical temperatures of the samples in a zero external field have also been studied. For high metal concentrations the results have been analyzed and found to fit the predictions of the dirty limit for type-II superconductors. Near the threshold, however, where the normal-state resistivity goes to infinity, the critical fields saturate to a finite value. This result is in accordance with the prediction of percolation theory in the anomalous diffusion regime. As the threshold is approached the anisotropy ratio decreases to a constant value of 1.2 from its homogeneous type-II limit 1.69

  13. review of review of trenchless techn trenchless techn dependence ...

    African Journals Online (AJOL)

    eobe

    2008-11-21

    Nov 21, 2008 ... method for installation of underground pipelines conduits of all sizes. ..... control of potable and foul water systems in. Zimbabwe resulting in the ...... of a Decision Support System for Selection of. Trenchless Technologies to ...

  14. mechanical sun mechanical sun-tracking techn tracking techn power

    African Journals Online (AJOL)

    User

    the maximum possible power. In order maximum power output from PV cells, the sunlig angle of ... means of a DC motor controlled by an intelligent drive unit that receive sors. .... be extracted using MPPT (MMPPT or electronic. MPPT) and ...

  15. Implementing Python for DrRacket

    OpenAIRE

    Ramos, Pedro Palma; Leitão, António Menezes

    2014-01-01

    The Python programming language is becoming increasingly popular in a variety of areas, most notably among novice programmers. On the other hand, Racket and other Scheme dialects are considered excellent vehicles for introducing Computer Science concepts. This paper presents an implementation of Python for Racket and the DrRacket IDE. This allows Python programmers to use Racket libraries and vice versa, as well as using DrRacket's pedagogic features. In particular, it allows architects and d...

  16. Brahm Prakash, Dr

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1972 Section: Engineering & Technology. Brahm Prakash, Dr Ph.D. (Panjab), FNA 1974-76. Date of birth: 21 August 1912. Date of death: 3 January 1984. Specialization: Metallurgy. YouTube; Twitter; Facebook; Blog ...

  17. Dr. David Syz, State Secretary for Economic Affairs, Switzerland

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Dr. David Syz, State Secretary for Economic Affairs, Switzerland, toured the assembly hall of the ATLAS experiment on a recent visit to CERN.Photos 01, 02: Dr. Peter Jenni, spokesperson for the ATLAS experiment (second from left), explains to Dr. David Syz (fourth from left) and accompanying visitors the process of integration of a 26-metre-long coil of the barrel toroid magnet system into its coil casing.Photo 03: Dr. Peter Jenni (extreme right) with Dr. David Syz (front row, fourth from right) behind a stack of 26-metre-long 'racetrack' coils awaiting integration into their coil casings.

  18. Hazarika, Dr Nabajit

    Indian Academy of Sciences (India)

    Hazarika, Dr Nabajit Ph.D. (Tezpur). Date of birth: 17 January 1986. Specialization: Remote Sensing, GIS Applications, Fluvial Geomorphology, Landuse Landcover Studies Address: Dept. of Environmental Science, Nagaland University, Lumami 798 627, Nagaland Contact: Residence: 94354 81256, 97066 71256

  19. Prakash, Dr Vishweshwaraiah

    Indian Academy of Sciences (India)

    Prakash, Dr Vishweshwaraiah Ph.D. (Mysore), FNASc, FNAE, FRSC,FNAAS. Date of birth: 23 November 1951. Specialization: S&T Policy, Physical Biochemistry, Chemistry of Macromolecules, Biophysics of Proteins, Enzymes & Thermodynamics, Food Chemistry, Nutrition, Food Biotechnology and Food Science Address: ...

  20. Dikshit, Dr Madhu

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2000 Section: Medicine. Dikshit, Dr Madhu Ph.D. (Kanpur), FNASc, FNA Council Service: 2016. Date of birth: 21 November 1957. Specialization: Redox Biology, Cardiovascular Pharmacology, Molecular Pharmacology, Neutrophiles and Nitric Oxide Synthase Address: Department ...

  1. Sethunathan, Dr Nambrattil

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1986 Section: Plant Sciences. Sethunathan, Dr Nambrattil Ph.D. (Madras), FNA, FNAAS, FNASc. Date of birth: 2 June 1937. Specialization: Environmental Microbiology Address: Flat No. 103, Ushodaya Apartments, Sri Venkateswara Officers' Colony, Ramakrishnapuram, Secunderabad 500 056, A.P.

  2. Mukerji, Dr Mitali

    Indian Academy of Sciences (India)

    Elected: 2014 Section: Medicine. Mukerji, Dr Mitali Ph.D. (IISc). Date of birth: 13 November 1967. Specialization: Functional Genomics, Population Genomics, Ayurgenomics Address: Sr Principal Scientist, Genomics & Molecualr Medicine, Institute of Genomics & Integrative Biology, Sukhdev Vihar, Mathura Road, New Delhi ...

  3. 76 FR 54770 - Public Meeting: Notification by Capital One Financial Corporation, McLean, VA, To Acquire ING...

    Science.gov (United States)

    2011-09-02

    ... FEDERAL RESERVE SYSTEM Public Meeting: Notification by Capital One Financial Corporation, McLean, VA, To Acquire ING Bank, FSB, Wilmington, DE, and Indirectly To Acquire Shares of Sharebuilder... Reserve System. ACTION: Notice of public meeting. SUMMARY: Three public meetings will be held regarding...

  4. Dr. Hans Chang, Director, Physics Research Committee, Stichting voor Fundamenteel Onderzoek der Materie (FOM), Dr. Joris Van Enst, Head of Science Policy Division, Ministry of Education, Culture and S cience, Dr. Jan Bezemer, NL Delegate CERN, Netherlands

    CERN Multimedia

    Patrice Loiez

    1999-01-01

    Dr. Hans Chang, Director, Physics Research Committee, Stichting voor Fundamenteel Onderzoek der Materie (FOM), Dr. Joris Van Enst, Head of Science Policy Division, Ministry of Education, Culture and S cience, Dr. Jan Bezemer, NL Delegate CERN, Netherlands

  5. Mukhopadhyay, Dr Sangita

    Indian Academy of Sciences (India)

    Elected: 2013 Section: Medicine. Mukhopadhyay, Dr Sangita Ph.D. (Utkal), FNASc. Date of birth: 1 January 1966. Specialization: Immunology, Cell Signalling, Communicable Diseases Address: Group Leader, Molecular Cell Biology, Centre for DNA Fingerprinting & Diagnostics, Nampally, Hyderabad 500 001, A.P.. Contact ...

  6. Mohanty, Dr Debasisa

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2012 Section: General Biology. Mohanty, Dr Debasisa Ph.D. (IISc), FNASc, FNA. Date of birth: 30 November 1966. Specialization: Bioinformatics, Computational & Structural Biology, Biophysics Address: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, ...

  7. Banerjee, Dr Srikumar

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1990 Section: Engineering & Technology. Banerjee, Dr Srikumar Ph.D. (IIT, Kharagpur), FNA, FNAE, FNASc, FTWAS Council Service: 2007-12; Vice-President: 2010-12. Date of birth: 25 April 1946. Specialization: Materials Science, Physical Metallurgy, Phase Transformations, Nuclear Fuel Cycle, ...

  8. Authikesavalu, Dr Munisamy

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1948 Section: Medicine. Authikesavalu, Dr Munisamy MBBS (Madras), MS (Minneapolis), FRCS. Date of birth: 16 August 1906. Date of death: 22 September 1973. Specialization: Experimental Surgery, Ophthalmology, Otolaryngology Last known address: 5-C, Lavelle Cross Road, ...

  9. Santhanam, Dr Vaidyanathaswamy

    Indian Academy of Sciences (India)

    Elected: 1974 Section: Plant Sciences. Santhanam, Dr Vaidyanathaswamy Ph.D. (Madras). Date of birth: 31 July 1925. Specialization: Plant Breeding & Genetics, Research Management and Cotton Development Address: 'Shri Abhirami', 107, Venkataswamy Road West, R S Puram Post, Coimbatore 641 002, T.N.. Contact:

  10. Amarjit Singh, Dr

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1974 Section: Engineering & Technology. Amarjit Singh, Dr Ph.D. (Harvard). Date of birth: 19 November 1924. Specialization: Millimeter Wave Tubes, Microwave Tubes and Microwave Electronics Address: 12, Auburn Court, Vernon Hills, IL 60061, USA Contact: Residence: ...

  11. Chandy, Dr Mammen

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2008 Section: Medicine. Chandy, Dr Mammen MD (Madras), FRACP, FRCPA. Date of birth: 30 August 1949. Specialization: Hematology, Bone Marrow Transplantation and Molecular Genetics of Blood Diseases Address: Director, Tata Memorial Centre, 14, Major Arterial Road, ...

  12. Shivaji, Dr Sisinthy

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2011 Section: Animal Sciences. Shivaji, Dr Sisinthy Ph.D. (Delhi), FNASc. Date of birth: 17 June 1950. Specialization: Anti-Microbial Resistance, Gut Microbiome, Eye Disease, Conservation Biology, Mammalian Sperm Function, Bacterial Biodiversity of Cold Habitats, Cold ...

  13. Potensi dan Efektivitas Pemungutan Retribusi RSUD Dr. Agoesdjam Ketapang

    OpenAIRE

    B61110063, JAMALUDIN

    2014-01-01

    This study entitled Potential and Effectiveness of retribution collecting in RSUD Dr. Agoesdjam Ketapang which aims to identify and analyze the potential retribution of RSUD Dr . Agoesdjam and also to investigate and analyze the effectiveness of the retribution collecting in RSUD Dr. Agoesdjam . This study uses secondary data , from 2008 to 2012 that were obtained from the Regional Revenue Office of Ketapang and RSUD Dr. Agoesdjam Ketapang . The method of this study is descriptive. To analyz...

  14. Dr. Irene Sänger-Bredt, a life for astronautics

    Science.gov (United States)

    Zaganescu, Nicolae-Florin

    2004-12-01

    Irene Bredt (b.1911 at Bonn) obtained her Doctorate in Physics in 1937; in the same year she became a scientific researcher at the German Research Center for Aviation at Trauen, led by Prof. Dr. Eugen Sänger. Soon, the young but efficient Dr. Irene Bredt became the first assistant of Dr. Sänger, who married her (1951). During 1973-1978, Dr. Bredt was in correspondence with Prof. Dr. Nikolae-Florin Zaganescu and helped him to familiarize the Romanian readers with Prof. Sänger's life and achievements. As for Dr. Bredt's life, she specified three main periods of her activity: 1937-1942, when she was researcher in charge of thermodynamic problems of liquid-fuelled rocket engines at Trauen 1942-1945, when she was Senior Researcher in charge of Ramjet in flight performances at Ainring, and also coauthored the Top Secret Technical report entitled 'A Rocket Engine for a Long-Range Bomber', which was finished in 1941 but edited only in 1944 the post world war II period, when she was Scientific Advisor or Director at various civil and military research institutes, universities, etc. Dr. Irene Sänger-Bredt helped her husband to develop many scientific theories like Ramjet thermodynamic theory, and photon rocket theory and also in establishing IAF and IAA. In 1970, Dr. Irene Sänger-Bredt was honored with 'Hermann Oberth Gold Medal' for her impressive scientific activity.

  15. Professor Bakytzhan Abdiraiym Rector of the L. Gumilov Eurasian National University, Astana, Kazakhstan accompanied by Prof. Kairat Kuterbekov, Dr Bekzat Prmantayeva, Dr Kuralay Maksut with the Director-General, Dr Tadeusz Kurtyka, Adviser for Non-Member States, Mrs Julia Andreeva, Department of Information Technologies and Dr Nikolai Zimine, ATLAS Collaboration, Joint Institute for Nuclear Research, Dubna

    CERN Document Server

    Maximilien Brice

    2011-01-01

    Professor Bakytzhan Abdiraiym Rector of the L. Gumilov Eurasian National University, Astana, Kazakhstan accompanied by Prof. Kairat Kuterbekov, Dr Bekzat Prmantayeva, Dr Kuralay Maksut with the Director-General, Dr Tadeusz Kurtyka, Adviser for Non-Member States, Mrs Julia Andreeva, Department of Information Technologies and Dr Nikolai Zimine, ATLAS Collaboration, Joint Institute for Nuclear Research, Dubna

  16. Chaddah, Dr Praveen

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1993 Section: Physics. Chaddah, Dr Praveen Ph.D. (Mumbai), FNA, FNASc. Date of birth: 20 December 1951. Specialization: Superconductivity, Low Temperature Physics and Phase Transitions Address: Flat 702, Block 24, Heritage City, MG Road (near Metro Station), Gurgaon ...

  17. Ranganathan, Dr Darshan

    Indian Academy of Sciences (India)

    Elected: 1991 Section: Chemistry. Ranganathan, Dr Darshan Ph.D. (Delhi), FNA. Date of birth: 4 June 1941. Date of death: 4 June 2001. Specialization: Organic Chemistry, Bio-Organic Chemistry and Supramolecular Chemistry Last known address: Scientist, Indian Institue of Chemical, Technology, Uppal Road, Hyderabad ...

  18. Description of Work for Borehole Sampling at the 116-DR-1and 116-DR-2 Trenches

    International Nuclear Information System (INIS)

    Bergstrom, K. A.

    1999-01-01

    This description of work (DOW) details the sampling and analysis activities for characterizing the deep zone soils below the 116-DR-1and 116-DR-2 trenches, which are located in the 100-DR- 1 Operable Unit (OU), and will serve as a guide for the personnel performing the work. The ''deep zone'' refers to the portion of the vadose zone between the bottom of the waste site and the water table. The scope of work includes drilling a borehole (B8786), sampling vadose zone and upper saturated zone soils at ∼ 1-m intervals, collecting a water sample below the top of the water table, and analyzing the samples for all contaminants of concern (COCs). Specific procedures for defined tasks are covered under the Bechtel Hanford, Inc. (BHI)manual, BHI-EE-01, Environmental Investigations Procedures

  19. Goldie Brangman Remembers the Operation to Save Dr King.

    Science.gov (United States)

    Koch, Evan; Brangman, Goldie

    2015-12-01

    In September 1958 the Rev Dr Martin Luther King Jr was stabbed and nearly assassinated. Surgeons at Harlem Hospital in New York City removed a 17.8-cm (7-in)-long letter opener from Dr King's chest. Certified Registered Nurse Anesthetist Goldie Brangman remembers this event because she participated in Dr King's anesthetic. This article correlates Brangman's memories with published accounts of the event. It also places the event within the context of the modern civil rights movement that Dr King led.

  20. Dr. Steve Thompson, Chief Executive, The Royal Society of New Zealand

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    L. to r.: Dr Austin Ball, Deputy Technical Coordinator, CMS experiment; Dr Roland Horisberger, Paul Scherrer Institute and CERN, CMS experiment; Dr Steve Thompson, Chief Executive, The Royal Society of New Zealand; Dr Michel Della Negra, Spokesman, CMS experiment and Dr Alick Macpherson, Paul Scherrer Institute and CERN, CMS experiment, in the CMS Silicon Tracker assembly hall.

  1. Bhandari, Dr Nita

    Indian Academy of Sciences (India)

    Elected: 2015 Section: Medicine. Bhandari, Dr Nita Ph.D. (JNU), FAMS. Date of birth: 9 November 1955. Specialization: Nutrition-Infection Interaction, Child Health, Nutritional Interventions, Clinical Evaluation of Vaccine Address: President & Director, Centre for Health R&D Society for Applied Studies, 45, Kalu Sarai, New ...

  2. Chandrasekaran, Dr Chidambara

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1945 Section: Mathematical Sciences. Chandrasekaran, Dr Chidambara Ph.D. (London) 1962-64. Date of birth: 30 October 1911. Date of death: 4 January 2000. Specialization: Statistics, Public Health and Demography Last known address: 'Sri Kripa', 79/3, Benson Cross Road, Bengaluru 560 046.

  3. Mukhopadhyay, Dr Amitabha

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2010 Section: General Biology. Mukhopadhyay, Dr Amitabha Ph.D. (Jadavpur), FNASc, FNA. Date of birth: 5 February 1959. Specialization: Cell Biology, Host-Pathogen Interactions, Drug Delivery Address: Staff Scientist VII, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, ...

  4. Chandy, Dr Jacob

    Indian Academy of Sciences (India)

    Elected: 1961 Section: Medicine. Chandy, Dr Jacob MBBS (Madras), FRCS (c) Council Service: 1962-70. Date of birth: 23 January 1910. Date of death: 23 June 2007. Specialization: Neurology, Neurosurgery and Medical Education Last known address: Paarra, Matteethra, Kottayam 686 004. YouTube; Twitter; Facebook ...

  5. Adhya, Dr Samit

    Indian Academy of Sciences (India)

    Elected: 1999 Section: General Biology. Adhya, Dr Samit Ph.D. (New York), FNA. Date of birth: 29 September 1953. Specialization: Mitochondrial Biology, Molecular Genetics of Parasites, Intracellular RNA Trafficking and DNA Diagnostics Address: CSIR Emeritus Scientist, Indian Inst. of Chemical Biology, 4, Raja S.C. ...

  6. Some neutron measurements with simulated ING targets

    Energy Technology Data Exchange (ETDEWEB)

    Walker, J

    1966-07-01

    Thermal neutron fluxes in the vicinity of a simulated Intense Neutron Generator target have been measured using Mn and Au foils, and a small BF{sub 3} detector. The target was a Pb cylinder either 4-inch or 8-inch in diameter with a 1.2 g Ra-Be neutron source at its centre. This was centrally mounted in a 5' diam. x 5' high tank which was filled with either H{sub 2}O or D{sub 2}O moderator. Various gaps and absorbing annuli were placed around the target, and air-filled aluminum 'beam tubes' were mounted radially or tangentially from the target to simulate typical ING conditions. The measured thermal neutron fluxes were less than calculated at all radii. The single-age computation clearly gives large errors at large radii, but the multi-energy approach seems to give a useful indication of the thermal flux distribution in spite of the extreme simplicity of the model. The fall in measured fluxes at small radii in both D{sub 2}O and H{sub 2}O is most likely caused by absorption in the target material which is not allowed for in the computational model. (author)

  7. Some neutron measurements with simulated ING targets

    International Nuclear Information System (INIS)

    Walker, J.

    1966-01-01

    Thermal neutron fluxes in the vicinity of a simulated Intense Neutron Generator target have been measured using Mn and Au foils, and a small BF 3 detector. The target was a Pb cylinder either 4-inch or 8-inch in diameter with a 1.2 g Ra-Be neutron source at its centre. This was centrally mounted in a 5' diam. x 5' high tank which was filled with either H 2 O or D 2 O moderator. Various gaps and absorbing annuli were placed around the target, and air-filled aluminum 'beam tubes' were mounted radially or tangentially from the target to simulate typical ING conditions. The measured thermal neutron fluxes were less than calculated at all radii. The single-age computation clearly gives large errors at large radii, but the multi-energy approach seems to give a useful indication of the thermal flux distribution in spite of the extreme simplicity of the model. The fall in measured fluxes at small radii in both D 2 O and H 2 O is most likely caused by absorption in the target material which is not allowed for in the computational model. (author)

  8. HLA-DR expression and disease activity in ulcerative colitis

    DEFF Research Database (Denmark)

    Poulsen, L O; Elling, P; Sørensen, Flemming Brandt

    1986-01-01

    and 3 months later. The rectal epithelial cells were HLA-DR-positive in all patients at the first two examinations. After 3 months five patients had changed to an HLA-DR-negative stage, whereas the other seven patients remained HLA-DR-positive. Closer analyses showed that expression/nonexpression of HLA...

  9. HLA-DR-expressing cells and T-lymphocytes in sural nerve biopsies

    DEFF Research Database (Denmark)

    Schrøder, H D; Olsson, T; Solders, G

    1988-01-01

    was confirmed. HLA-DR expression was found in all biopsies and thus was not restricted to any particular type of neuropathy. The HLA-DR expression appeared to correlate with severity and activity of the neuropathy. HLA-DR-expressing macrophages wrapping myelinated fibers were prominent in primary demyelinating......Thirty-five sural nerve biopsies were stained immunohistochemically for HLA-DR antigen. HLA-DR was expressed on nonmyelinating Schwann cells, macrophages, vascular endothelium, and perineurium. By means of double immunofluorescence staining the identity of the HLA-DR presenting structures...

  10. Varadarajan, Dr Srinivasan

    Indian Academy of Sciences (India)

    Elected: 1972 Section: Chemistry. Varadarajan, Dr Srinivasan Ph.D. (Delhi and Cantab), D.Sc. (h.c.), D.Litt. (h.c.), FNA, FNAE, FTWAS Council Service:1974-88; Vice-President: 1977-79; President: 1980-82. Date of birth: 31 March 1928. Specialization: Organic & Biological Chemistry, Molecular Biology, Engineering Design ...

  11. Sengupta, Dr Sagar

    Indian Academy of Sciences (India)

    Sengupta, Dr Sagar Ph.D. (IISc), FNA, FNASc. Date of birth: 23 June 1968. Specialization: Cancer Biology, Cell Signalling, Mytochondrial Biology Address: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, U.T.. Contact: Office: (011) 2670 3786. Residence: (0124) 422 7107. Mobile: 93131 05470

  12. Sengupta, Dr Sagar

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2017 Section: General Biology. Sengupta, Dr Sagar Ph.D. (IISc), FNA, FNASc. Date of birth: 23 June 1968. Specialization: Cancer Biology, Cell Signalling, Mytochondrial Biology Address: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, U.T.. Contact: Office: (011) 2670 3786

  13. DR6 as a diagnostic and predictive biomarker in adult sarcoma.

    Directory of Open Access Journals (Sweden)

    Kun Yang

    Full Text Available The Death Receptor 6 (DR6 protein is elevated in the serum of ovarian cancer patients. We tested DR6 serum protein levels as a diagnostic/predictive biomarker in several epithelial tumors and sarcomas.DR6 gene expression profiles were screened in publically available arrays of solid tumors. A quantitative immunofluorescent western blot analysis was developed to test the serum of healthy controls and patients with sarcoma, uterine carcinosarcoma, bladder, liver, and pancreatic carcinomas. Change in DR6 serum levels was used to assay the ability of DR6 to predict the response to therapy of sarcoma patients.DR6 mRNA is highly expressed in all tumor types assayed. Western blot analysis of serum DR6 protein demonstrated high reproducibility (r = 0.97. Compared to healthy donor controls, DR6 serum levels were not elevated in patients with uterine carcinosarcoma, bladder, liver, or pancreatic cancers. Serum DR6 protein levels from adult sarcoma patients were significantly elevated (p<0.001. This was most evident for patients with synovial sarcoma. Change in serum DR6 levels during therapy correlated with clinical benefit from therapy (sensitivity 75%, and positive predictive value 87%.DR6 may be a clinically useful diagnostic and predictive serum biomarker for some adult sarcoma subtypes.Diagnosis of sarcoma can be difficult and can lead to improper management of these cancers. DR6 serum protein may be a tool to aid in the diagnosis of some sarcomatous tumors to improve treatment planning. For patients with advanced disease, rising DR6 levels predict non-response to therapy and may expedite therapeutic decision making and reduce reliance on radiologic imaging.

  14. Gaia DR2 documentation Chapter 7: Variability

    Science.gov (United States)

    Eyer, L.; Guy, L.; Distefano, E.; Clementini, G.; Mowlavi, N.; Rimoldini, L.; Roelens, M.; Audard, M.; Holl, B.; Lanzafame, A.; Lebzelter, T.; Lecoeur-Taïbi, I.; Molnár, L.; Ripepi, V.; Sarro, L.; Jevardat de Fombelle, G.; Nienartowicz, K.; De Ridder, J.; Juhász, Á.; Molinaro, R.; Plachy, E.; Regibo, S.

    2018-04-01

    This chapter of the Gaia DR2 documentation describes the models and methods used on the 22 months of data to produce the Gaia variable star results for Gaia DR2. The variability processing and analysis was based mostly on the calibrated G and integrated BP and RP photometry. The variability analysis approach to the Gaia data has been described in Eyer et al. (2017), and the Gaia DR2 results are presented in Holl et al. (2018). Detailed methods on specific topics will be published in a number of separate articles. Variability behaviour in the colour magnitude diagram is presented in Gaia Collaboration et al. (2018c).

  15. The intense neutron generator INGE-1 at the Technical University of Dresden

    International Nuclear Information System (INIS)

    Bittner, M.; Meisner, A.; Paffrath, E.; Schwiers, H.; Seeliger, D.

    1989-01-01

    The INGE-1 neutron generator developed for intergal 14 MeV neutron experiments is described. The accelerator produces steady d + ion beam in the current range of 1-10 mA with 120-240 keV energies at the target position. The beam is produced with a combined duoplasmatron focalization system on high voltage. A 30 keV beam is accelerated on final energy by a two-gap acceleration tube. The estimations conducted show that the generator maximum strength can reach up to 2x10 12 s -1 at 10 mA beam current and 220 keV energy. 4 refs

  16. Jameel, Dr Shahid

    Indian Academy of Sciences (India)

    Jameel, Dr Shahid Ph.D. (Washington State Univ.), FNASc, FNA. Date of birth: 8 August 1957. Specialization: Molecular Biology and Molecular Virology Address: Chief Executive Officer, The Wellcome Trust/DBT India Alliance, 8-2-684/3/K/19, Kaushik Society, Road NO. 12, Banjara Hills, Hyderabad 500 034, A.P.. Contact:

  17. Dr. Albert Carr--Science Educator 1930-2000

    Science.gov (United States)

    Lopez, Leslie

    2013-01-01

    The very first issue of "Educational Perspectives" was published in October of 1962. Dr. Albert Carr wrote one of the inaugural essays on the topic of current developments in science education, and he went on to write several other articles for the journal. This article shares why Dr. Albert Carr's colleagues remember him for his…

  18. Le "projet G." : une ingénierie de formation. Conception et gestion d'un dispositif d'enseignement (le geste et l'effet)

    OpenAIRE

    Marty , Olivier

    2012-01-01

    Document de travail pour l'Axe 4 "Organisations et formation" du CRF [Avec une note additive formalisant les données empiriques]; Le projet d'ingénierie de formation décrit consiste à développer une école de gestion en ligne, d'une durée de trois années, visant un public d'une soixantaine de néo-bacheliers, avec une équipe pédagogique d'une dizaine d'enseignants employés par le Ministère. Décrire ce projet nous permet de présenter l'organisation et l'ingénierie de formation en utilisant à la ...

  19. A Tribute to Dr. Willy Lens

    Directory of Open Access Journals (Sweden)

    Maarten Vansteenkiste

    2016-07-01

    Full Text Available Dr. Willy Lens, born on December 10th, 1943, passed away on August 29th, 2014. With his passing, the motivation community has lost a seminal member, a mentor, and a friend. Dr. Lens – a Fellow of the Association for Psychological Science and Founding Fellow of the American Educational Research Association – made fundamental contributions to the study of motivation both through his own work and through his caring and thoughtful mentorship of a large community of scholars. With this tribute, we want to honor Dr. Willy Lens’ significance to psychology and education as well as his positive influence, both personally and professionally, on the lives of dozens of scholars. With his contagious enthusiasm and caring mentorship, Willy was an example for our academic community and with this tribute we express our gratitude for the privilege to have collaborated with him.

  20. Drømmebilleder

    DEFF Research Database (Denmark)

    Fausing, Bent

    2014-01-01

    Bogen beskriver i en række intense analyser forbindelsen mellem ydre og indre billeder: altså mellem de moderne mediers billedverden og drømmens og erindringens indre billeder. I fokus for undersøgelsen er desuden kønnet, altså hvordan billeder viser, omformer eller skjuler kønnet, 'det andet', s...

  1. Kui suur palk oleks õpetaja töö vääriline? / Inge Kalle, Maia Uibo, Lauri Leesi ... [jt.

    Index Scriptorium Estoniae

    2011-01-01

    Küsimusele vastavad Vastse-Kuuste kooli direktor Inge Kalle, Ülenurme gümnaasiumi õpetaja-metoodik Maia Uibo, Tallinna Prantsuse Lütseumi direktor Lauri Leesi, Saaremaa ühisgümnaasiumi direktor Viljar Aro ja Heimtali põhikooli direktor Eero Metsavahi

  2. Profile Interview: Dr. Patrick Dongosolo Kamalo – Consultant ...

    African Journals Online (AJOL)

    Dr. Yohane Gadama (YG), an MMJ intern, interviews Dr. Patrick Dongosolo Kamalo (PDK) on his work as Malawi's only local practicing neurosurgeon, the launch of Blantyre Institute of Neurological Sciences (BINS) and the beginning of Neurosurgery training in Malawi ...

  3. Mishra, Dr A C

    Indian Academy of Sciences (India)

    Elected: 2009 Section: Medicine. Mishra, Dr A C . Ph.D. (Pune), FNA. Date of birth: 1 July 1950. Specialization: Human Viral Infection & Zoonotic Diseases, Public Health Address: Director, Interactive Research School of Health Affairs, Bharati Vidyapeeth University, ...

  4. Thiagarajan, Dr Pazhamaneri Subramaniam

    Indian Academy of Sciences (India)

    Elected: 1995 Section: Mathematical Sciences. Thiagarajan, Dr Pazhamaneri Subramaniam Ph.D. (Rice), FNASc. Date of birth: 9 November 1948. Specialization: Distributed Probabilistic Systems, Hybrid Systems and Computational Systems Biology Address: Laboratory of System Pharmacology, Harvard Medical School, ...

  5. Association between HLA-DR antigens and rheumatoid arthritis in Arabs.

    OpenAIRE

    Sattar, M A; al-Saffar, M; Guindi, R T; Sugathan, T N; Behbehani, K

    1990-01-01

    Eighty five Arab patients with classical and definite rheumatoid arthritis were typed to determine the prevalence of HLA A, B, C, and DR antigens. A significant increase in the prevalence of HLA-A10, B8, B21, and DR3 was found in comparison with a control population matched for age and sex. HLA-DR5 was significantly decreased in the patient group. The classical association of HLA-DR4 with rheumatoid arthritis could not be confirmed in the Arab patients resident in Kuwait, supporting reported ...

  6. Queer(y)ing New Schooling Accountabilities through "My School": Using Butlerian Tools to Think Differently about Policy Performativity

    Science.gov (United States)

    Gowlett, Christina

    2015-01-01

    This article takes the role of provocateur to "queer(y)" the rules of intelligibility surrounding new schooling accountabilities. Butler's work is seldom used outside the arena of gender and sexualities research. A "queer(y)ing" methodology is subsequently applied in a context very different to where it is frequently…

  7. Budhani, Dr Ramesh Chandra

    Indian Academy of Sciences (India)

    Budhani, Dr Ramesh Chandra Ph.D. (IIT, Delhi), FNASc, FNA. Date of birth: 3 February 1955. Specialization: Renewable Energy, Nanoscale Systems, Experimental Condensed Matter Physics, Superconductivity and Magnetism Address: Department of Physics, Lasers & Photonics, Indian Institute of Technology, Kanpur 208 ...

  8. Salunke, Dr Dinakar Mashnu

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2001 Section: General Biology. Salunke, Dr Dinakar Mashnu Ph.D. (IISc), FNASc, FNA, FTWAS. Date of birth: 1 July 1955. Specialization: Structural Biology, Macromolecular Crystallography and Immunology Address: Director, International Centre for Genetic Engineering, & Biotechnology, Aruna Asaf ...

  9. Watve, Dr Milind Gajanan

    Indian Academy of Sciences (India)

    Date of birth: 12 December 1957. Specialization: Wildlife Ecology & Animal Cognition, Evolutionary Biology, Computational Biology and Microbial Diversity Address: Professor, Biology, Indian Institute of Science Education & Research, Dr Homi Bhabha Road, Pashan, Pune 411 008, Maharashtra Contact: Office: (020) 2590 ...

  10. Shivanna, Dr Kundaranahalli Ramalingaiah

    Indian Academy of Sciences (India)

    Elected: 1985 Section: Plant Sciences. Shivanna, Dr Kundaranahalli Ramalingaiah Ph.D. (Delhi), FNA, FNAAS, FNASc. Date of birth: 30 June 1940. Specialization: Pollen Biology, Reproductive Ecology and Conservation Biology Address: Odekar Farms, Nandihalli, via Thovinakere, Tumkur 572 138, Karnataka Contact:

  11. Gaia DR1 documentation

    Science.gov (United States)

    van Leeuwen, F.; de Bruijne, J. H. J.; Arenou, F.; Comoretto, G.; Eyer, L.; Farras Casas, M.; Hambly, N.; Hobbs, D.; Salgado, J.; Utrilla Molina, E.; Vogt, S.; van Leeuwen, M.; Abreu, A.; Altmann, M.; Andrei, A.; Babusiaux, C.; Bastian, U.; Biermann, M.; Blanco-Cuaresma, S.; Bombrun, A.; Borrachero, R.; Brown, A. G. A.; Busonero, D.; Busso, G.; Butkevich, A.; Cantat-Gaudin, T.; Carrasco, J. M.; Castañeda, J.; Charnas, J.; Cheek, N.; Clementini, G.; Crowley, C.; Cuypers, J.; Davidson, M.; De Angeli, F.; De Ridder, J.; Evans, D.; Fabricius, C.; Findeisen, K.; Fleitas, J. M.; Gracia, G.; Guerra, R.; Guy, L.; Helmi, A.; Hernandez, J.; Holl, B.; Hutton, A.; Klioner, S.; Lammers, U.; Lecoeur-Taïbi, I.; Lindegren, L.; Luri, X.; Marinoni, S.; Marrese, P.; Messineo, R.; Michalik, D.; Mignard, F.; Montegriffo, P.; Mora, A.; Mowlavi, N.; Nienartowicz, K.; Pancino, E.; Panem, C.; Portell, J.; Rimoldini, L.; Riva, A.; Robin, A.; Siddiqui, H.; Smart, R.; Sordo, R.; Soria, S.; Turon, C.; Vallenari, A.; Voss, H.

    2017-12-01

    We present the first Gaia data release, Gaia DR1, consisting of astrometry and photometry for over 1 billion sources brighter than magnitude 20.7 in the white-light photometric band G of Gaia. The Gaia Data Processing and Analysis Consortium (DPAC) processed the raw measurements collected with the Gaia instruments during the first 14 months of the mission, and turned these into an astrometric and photometric catalogue. Gaia DR1 consists of three parts: an astrometric data set which contains the positions, parallaxes, and mean proper motions for about 2 million of the brightest stars in common with the Hipparcos and Tycho-2 catalogues (the primary astrometric data set) and the positions for an additional 1.1 billion sources (the secondary astrometric data set). The primary set forms the realisation of the Tycho-Gaia Astrometric Solution (TGAS). The second part of Gaia DR1 is the photometric data set, which contains the mean G-band magnitudes for all sources. The third part consists of the G-band light curves and the characteristics of 3000 Cepheid and RR Lyrae stars observed at high cadence around the south ecliptic pole. The positions and proper motions in the astrometric data set are given in a reference frame that is aligned with the International Celestial Reference Frame (ICRF) to better than 0.1 mas at epoch J2015.0, and non-rotating with respect to the ICRF to within 0.03 mas yr^-1. For the primary astrometric data set, the typical standard error for the positions and parallaxes is about 0.3 mas, while for the proper motions the typical standard error is about 1 mas yr^-1. Whereas it has been suggested in Gaia Collaboration et al. (2016a) that a systematic component of ∼0.3 mas should be 'added' (in quadrature) to the parallax uncertainties, Brown (2017) clarifies that reported parallax standard errors already include local systematics as a result of the calibration of the TGAS parallax uncertainties by comparison to Hipparcos parallaxes. For the subset of

  12. Safety evaluation for packaging for 1720-DR sodium-filled tank

    International Nuclear Information System (INIS)

    Mercado, M.S.

    1996-01-01

    Preparations are under way to sell the sodium stored in the 1720-DR tank in the 1720-DR building. This will require that the tank, as well as the 1720-DR facility, be moved to the 300 Area, so that the sodium may be melted and transferred into a railroad tanker car. Because the sodium is a hazardous material and is being shipped in a nonspecification packaging, a safety evaluation for packaging (SEP) is required. This SEP approves the sodium-filled tank for a single shipment from the 105-DR area to the 300 Area

  13. Chandrashekar, Dr Tavarekere Kalliah

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2000 Section: Chemistry. Chandrashekar, Dr Tavarekere Kalliah Ph.D. (IISc), FNASc, FNA, FTWAS Council Service: 2013-15. Date of birth: 1 January 1956. Specialization: Bio-inorganic Chemistry, Synthetic Inorganic Chemistry and Catalysis Address: Senior Professor, School of Chemical Sciences, ...

  14. Majumdar, Dr Subeer Suhash

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2014 Section: Animal Sciences. Majumdar, Dr Subeer Suhash Ph.D. (nagpur), FNA, FNASc. Date of birth: 21 May 1961. Specialization: Animal Biotechnology, Transgenic Animals, Endocrinology Address: Director, National Institute of Animal Biotechnology, Gopan Pally, Hyderabad 500 046, A.P.

  15. Gupta, Dr Chhitar Mal

    Indian Academy of Sciences (India)

    Gupta, Dr Chhitar Mal Ph.D. (Agra), FNA, FNASc, FAMS, FTWAS Council Service: 1998-2000. Date of birth: 1 September 1944. Specialization: Membrane Biology, Bio-organic Chemistry and Molecular Biophysics Address: Distinguished Professor and Infosys Chair, Institute of Bioinformatics & Applied Biotechnology, Room ...

  16. Babu, Dr Cherukuri Raghavendra

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1990 Section: Plant Sciences. Babu, Dr Cherukuri Raghavendra D.Phil. (Calcutta). Date of birth: 30 June 1940. Specialization: Biosystematics, Ecology and Population Genetics Address: Professor Emeritus, CEMDE, School of Environmental Studies, University of Delhi, Delhi 110 007, U.T.. Contact:

  17. Anil, Dr Arga Chandrashekar

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2015 Section: Earth & Planetary Sciences. Anil, Dr Arga Chandrashekar Ph.D. (Karnatak). Date of birth: 23 January 1959. Specialization: Biological Oceanography, Marine Ecology, Marine Biology Address: Chief Scientist, National Institute of Oceanography, Dona Paula 403 004, ...

  18. Sharma, Dr Ram Swaroop

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1989 Section: Earth & Planetary Sciences. Sharma, Dr Ram Swaroop Ph.D. (Basel), FNA. Date of birth: 10 July 1937. Specialization: Metamorphic Petrology, Mineralogy and Precambrian Geology Address: 70/36, Pratapnagar, Sector 7, Sanganer (RHB), Jaipur 302 033, Rajasthan

  19. Dr Satish R. Shetye

    Indian Academy of Sciences (India)

    Elected: 1992 Section: Earth & Planetary Sciences. Shetye, Dr Satish Ramnath Ph.D. (Washington), FNA, FNASc. Council Service: 1998-2003. Date of birth: 25 October 1950. Specialization: Physical Oceanography Address: Vice Chancellor, Goa University, Taleigao Plateau 403 206, Goa Contact: Office: (0832) 651 9001

  20. Jena, Dr Prafulla Kumar

    Indian Academy of Sciences (India)

    Jena, Dr Prafulla Kumar Ph.D. (Utkal). Date of birth: 27 December 1931. Specialization: Extractive Metallurgy, Mineral Processing, Environmental Engineering and Materials Processing Address: Chairman, Institute of Advance Technology and Environmental Studies, 80A-831A Lewis Road, Bhubaneswar 751 002, Orissa

  1. Kulkarni, Dr Mohan Gopalkrishna

    Indian Academy of Sciences (India)

    Elected: 1996 Section: Engineering & Technology. Kulkarni, Dr Mohan Gopalkrishna Ph.D. (Mumbai), FNAE. Date of birth: 14 November 1950. Specialization: Polymer Science & Engineering, Intellectual Property Address: Emeritus Scientist, Unit for R&D of Information Products, Tapovan, NCL Campus, Pashan Road, Pune ...

  2. Apte, Dr Shree Kumar

    Indian Academy of Sciences (India)

    Elected: 2008 Section: General Biology. Apte, Dr Shree Kumar Ph.D. (Gujarat), FNA, FNASc, FNAAS. Date of birth: 18 October 1952. Specialization: Molecular Biology & Biotechnology, Physiology and Stress Biology of Bacteria & Plants Address: Emeritus Professor, Homi Bhabha National Institute, Anushakti Nagar, ...

  3. Teaching medicine with the help of "Dr. House".

    Science.gov (United States)

    Jerrentrup, Andreas; Mueller, Tobias; Glowalla, Ulrich; Herder, Meike; Henrichs, Nadine; Neubauer, Andreas; Schaefer, Juergen R

    2018-01-01

    TV series such as "House MD", "Grey´s Anatomy" or "Emergency Room" are well perceived by medical students. Seminars featuring medical TV series such as "House MD" might serve as door-opener to attract medical students to learn more about rare diseases. The TV series "House MD" is troublesome for the main character Dr. House is an excellent diagnostician but at the same time a rather misanthropic person. Therefore, lecturing medicine with the help of "House MD" requires constant evaluation. From 2008 to 2016 we are using the well-known TV series "House MD" continuously to attract medical students and teach them about rare diseases as well as diagnostic strategies. We collected from 213 students a detailed questionnaire assessing their learning experience. 76.6% of our students (n = 157) reported to watching medical dramas on a regular basis. The Dr. House seminar was compared to traditional seminars and our students reported an improved learning effect (69.9%), better concentration (89.7%), higher motivation to participate (88.7%), and more fun (86.7%) (all pHouse's behavior quite critically. Likert assessment on a 5-point scale identified strong disagreement with Dr. House´s interpersonal skills in dealing with his colleagues (median = 1) and patients (median = 1). At the same time, the students strongly agreed with his outstanding diagnostic (median = 5) and therapeutic capabilities (median = 4). Medical students visiting a Dr. House teaching seminar are highly motivated to learn more about rare diseases. They were positively influenced by TV series such as Dr. House to improve their diagnostic and clinical skills. At the same time, they are critical enough not to see Dr. House as a role model for their own personality. Well performed medical TV shows such as Dr. House can successfully be used in an educational setting to motivate medical students to come into seminars to learn more about rare diseases.

  4. Dr. Tulp's Anatomy Lesson by Rembrandt: the third day hypothesis.

    Science.gov (United States)

    Afek, Arnon; Friedman, Tal; Kugel, Chen; Barshack, Iris; Lurie, Doron J

    2009-07-01

    An autopsy was an important event in 17th century Holland. Autopsies were held in an 'anatomy theater' and performed according to a fixed protocol that often took up to 3 days to complete. Of the five group portraits painted by Rembrandt over the course of his career, two were anatomy lessons given by Dr. Tulp and Dr. Deyman. An examination of Rembrandt's painting Dr. Tulp's Anatomy Lesson (1632) and an X-ray image of the painting, as compared to other paintings of anatomy lessons from the same period, reveal interesting differences, such as positioning, and light and shadow. Not only was the autopsy not performed according to the usual protocol, but in this painting Rembrandt created a unique dramatic scene in his effort to tell a story. We suggest that Dr. Tulp and Rembrandt "modified" the painting of Dr. Tulp's anatomy lesson to emphasize Dr. Tulp's position as the greatest anatomist of his era--"Vesalius of Amsterdam," and as a way of demonstrating God's greatness by highlighting the hand as a symbol of the most glorious of God's creations.

  5. Brahmayya Sastry, Dr Podila

    Indian Academy of Sciences (India)

    Elected: 1978 Section: Medicine. Brahmayya Sastry, Dr Podila Ph.D. (McGill). Date of birth: 24 May 1913. Date of death: 28 May 1993. Specialization: Physiology, Neurophysiology and Placental Physiology Last known address: Sitaramanilayam, Plot No. 9, Doctors Co-Operative Housing Colony, Waltair, Visakhapatnam ...

  6. Chitnis, Dr Chetan Eknath

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2009 Section: Medicine. Chitnis, Dr Chetan Eknath Ph.D. (UC, Berkeley), FNA. Date of birth: 3 April 1961. Specialization: Molecular Parasitology, Vaccine Development for Malaria and Molecular & Cell Biology Address: Head, Malaria Parasite Biology & Vaccine, Institut Pasteur, 28, ...

  7. Sharma, Dr Surendra Kumar

    Indian Academy of Sciences (India)

    Elected: 2010 Section: Medicine. Sharma, Dr Surendra Kumar Ph.D. (AIIMS), MD (PGIMER, Chandigarh), FNASc, FNA. Date of birth: 22 February 1951. Specialization: Environmental Medicine, Infectious Diseases, Internal Medicine, Pulmonary & Critical Care and Sleep Medicine Address: B-5/3, B Block, Sector 13, RK ...

  8. Valluri, Dr Sitaram Rao

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1971 Section: Engineering & Technology. Valluri, Dr Sitaram Rao Ph.D. (Caltech). Date of birth: 25 June 1924. Specialization: Metal Fatigue Address: 'Prashanthi', 659, 100 Feet Road, Indiranagar, Bengaluru 560 038, Karnataka Contact: Residence: (080) 2525 8294. YouTube ...

  9. Shastry, Dr B Sriram

    Indian Academy of Sciences (India)

    Shastry, Dr B Sriram Ph.D. (Mumbai), FNA, FNASc, FTWAS. Date of birth: 26 November 1950. Specialization: Strongly-Correlated Fermi Systems, Quantum Integrable Systems Address: Distinguished Professor, Department of Physics, University of California, Santa Cruz, CA 95064, USA Contact: Office: (+1-831) 459 5849

  10. Gangal, Dr Sharad Vishwanath

    Indian Academy of Sciences (India)

    Gangal, Dr Sharad Vishwanath Ph.D. (Mumbai), FNASc. Date of birth: 2 May 1937. Specialization: Allergy, Immunology and Biochemistry Address: Lakshmi Niwas, Opp. Santoshi Mata Temple (B Cabin), Sane Guruji Path, Naupada, Thane 400 602, Maharashtra Contact: Residence: (022) 2537 6961. Mobile: 93249 24307

  11. Paranjpe, Dr Pramod Anand

    Indian Academy of Sciences (India)

    Elected: 1975 Section: Engineering & Technology. Paranjpe, Dr Pramod Anand D.Sc. Tech. (ETH Zurich). Date of birth: 1 April 1934. Specialization: Turbomachinery and Jet Propulsion Systems Address: 'Bahaar', 5, Hindustan Estate, Road No. 13, Kalyaninagar, Pune 411 006, Maharashtra Contact: Residence: (020) 2668 ...

  12. Thakur, Dr Vikram Chandra

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1991 Section: Earth & Planetary Sciences. Thakur, Dr Vikram Chandra Ph.D. (London). Date of birth: 15 January 1940. Specialization: Structural Geology, Tectonics of Himalayan Geology and Active Tectonics Address: 9/12 (Lane 9), Ashirwad Eclave, Dehra Dun 248 001, ...

  13. Gangal, Dr Sudha Gajanan

    Indian Academy of Sciences (India)

    Gangal, Dr Sudha Gajanan Ph.D. (Mumbai), FNA Council Service: 1995-97. Date of birth: 25 August 1934. Specialization: Cancer & Basic Immunology, Cell Biology and Genetic Diseases Address: 4, Mahavishnu Apartments, Dahanukar Colony A, Kothrud, Pune 411 029, Maharashtra Contact: Residence: (020) 2538 4382, ...

  14. Mishra, Dr Rakesh K

    Indian Academy of Sciences (India)

    Mishra, Dr Rakesh K Ph.D. (Allahabad), FNASc, FNA. Date of birth: 14 April 1961. Specialization: Genomics, Chromatin, Epigenetics Address: Director, Centre for Cellular & Molecular Biology, Uppal Road, Hyderabad 500 007, A.P.. Contact: Office: (040) 2719 2600. Residence: (040) 2720 6400. Mobile: 94419 02188

  15. Parnaik, Dr Veena Krishnaji

    Indian Academy of Sciences (India)

    Elected: 2008 Section: Animal Sciences. Parnaik, Dr Veena Krishnaji Ph.D. (Ohio State), FNA. Date of birth: 22 August 1953. Specialization: Cell Biology, Molecular Biology, Lamins and Nuclear Organisation Address: INSA Senior Scientist, Centre for Cellular & Molecular Biology, Uppal Road, Hyderabad 500 007, A.P.

  16. Dr. Shi Hanzhang's Experience in Treating Andropathy

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Dr. Shi Hanzhang (施汉章) of Dongzhimen Hospital affiliated to Beijing University of Traditional Chinese Medicine is experienced in both teaching and clinical practice, especially in treating andropathy, such as sexual disorder, infertility, and hyperplasia of the prostate. The author has the honour to follow him for study and really learned a lot from him. A brief introduction to Dr. Shi's way of thinking in treatment is as follows.

  17. Volume celebrating the 60th birthday of Professor Dr. Franz Fie; Professor Dr. Franz Fiedler zum 60. Geburtstag

    Energy Technology Data Exchange (ETDEWEB)

    Beheng, K.D. [ed.

    1998-01-01

    This report was compiled in honor of Professor Dr. Franz Fiedler on the occasion of his 60th birthday on 7 January 1998. Its contributions deal with mesoscale modelling, the propagation of air pollutants, measurements of precipitation using radar, and prediction models. (orig./KW) [Deutsch] Dieser Bericht wurde aus Anlass des 60. Geburtstags von Herrn Prof. Dr. Franz Fiedler am 7. Januar 1998 zusammengestellt. Die Beitraege behandeln mesoskalige Modellierung, Ausbreitung von Luftschadstoffen, Niederschlagsmessung mit Radar und Vorhersagemodelle. (orig.)

  18. Lignine als grondstof voor asfalt en dakbedekking

    NARCIS (Netherlands)

    Vliet, D. van

    2014-01-01

    Zet een chemicus en een wegenbouwer bij elkoor en je kunt het onverwachte verwachten. Somen brouwden dr. Ted Sloghek en ing. Dave van Vliet van TNO een type bitumen met verbeterde eigenschoppen. Het basismateriaal: lignine

  19. Quality of wooden chips produced by Claas Jaguar fitted with experimental CRA-ING rotor

    Energy Technology Data Exchange (ETDEWEB)

    Pari, L.; Civitarese, V.; Del Giudice, A. [Council for Research in Agriculture, Agricultural Engineering Research Unit, Rome (Italy)

    2010-07-01

    This paper described a newly developed chipper device for mounting on Claas Jaguar chipper harvesters for short rotation forestry harvesting. It was designed by the Agriculture Engineering Research Unit of the Agricultural Research Council in Rome, Italy. The new rotor has a lower number of blades compared to standard rotors and has a different cutting angle and drum insertion. This study evaluated the particle-size distribution of wood chips produced by standard rotors compared to those with the experimental rotor. The objective was to distinguish the particle size distribution of chips produced using the two types of chippers in order to evaluate the influence of wooden species in the chip formation process. Tests were conducted using 860 and 890 Claas Jaguar chipper harvesters, both equipped with standard and CRA-ING rotors. The experiment was conducted on poplar cultivations on biennial shift and on arboreal cultivations. Compared to traditional rotors, CRA-ING rotors provide a considerable product increase within particle sizes ranging from 12.5 to 25 mm, and an equivalent product reduction within the finest particle size classes. The study showed that the new rotor tends to concentrate dimensional increments along the longitudinal section of the chip, regardless of the species used. In order to obtain a better quality chip in terms of particle size, a second rotor was devised to engrave a cleaner cut on the biomass introduced by the feeding rollers.

  20. For Dr. Nancy Snyderman's Parents, Staying Close to Family Is Key

    Science.gov (United States)

    ... to move closer to their daughter and her family, as part of the next chapter in their lives. Photo courtesy of Dr. Nancy Snyderman As Chief Medical Editor for NBC News and host of the popular MSNBC show, Dr. Nancy , Dr. ...

  1. DR and CR: Recent advances in technology

    International Nuclear Information System (INIS)

    Schaefer-Prokop, C.M.; De Boo, D.W.; Uffmann, M.; Prokop, M.

    2009-01-01

    After some initial reluctance, nowadays transition from conventional analogue-to-digital radiographic technique is realized in the vast majority of institutions. The eventual triumph of digital over conventional technique is related to its undoubted advantages with respect to image quality and improved image handling in the context of a picture archiving and communication system. CR represents the older system, which matured over decades and experienced some important recent improvements with respect to dose efficiency and work-flow efficiency that strengthened its position. It represents a very versatile, economically attractive system that is equally suited for integrated systems as well as for cassette-based imaging at the bedside. DR systems offer superb image quality and realistic options for dose reduction based on their high dose efficiency. While for a long time only integrated systems were on the market suited for a large patient throughput, also mobile DR systems became recently available. While for the next years, it is likely that DR and CR systems will coexist, the long term perspective of CR will depend on further innovations with respect to dose efficiency and signal-to-noise characteristics while for DR economical aspects and broader availability of mobile systems will play a role.

  2. Bal, Dr Dattatreya Vaman

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1943 Section: Animal Sciences. Bal, Dr Dattatreya Vaman Ph.D. (Liverpool). Date of birth: 25 August 1905. Date of death: 1 April 1999. Specialization: Marine Zoology, Oceanography. Fisheries and Aquaculture Last known address: 104, Swaroop Complex, Karve Road, Pune 411 ...

  3. Bhawalkar, Dr Dilip Devidas

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1986 Section: Physics. Bhawalkar, Dr Dilip Devidas Ph.D. (Southampton), FNA, FNASc. Date of birth: 16 October 1940. Specialization: Lasers and laser Instrumentation Address: 26, Paramanu Nagar, Indore 452 013, M.P.. Contact: Office: (0731) 232 2707. Residence: (0731) 232 0031. Mobile: 93032 ...

  4. Agrewala, Dr Javed Naim

    Indian Academy of Sciences (India)

    Agrewala, Dr Javed Naim Ph.D. (Agra), FNA, FNASc. Date of birth: 14 May 1961. Specialization: Immunology, Vaccine, Drug Discovery Address: Chief Scientist, Immunology Laboratory, Institute of Microbial Technology, Sector 39A, Chandigarh 160 036, U.T.. Contact: Office: (0172) 666 5261. Residence: (0172) 666 5514

  5. Barua, Dr Asok Kumar

    Indian Academy of Sciences (India)

    Elected: 1987 Section: Physics. Barua, Dr Asok Kumar Ph.D. (Calcutta). Date of birth: 1 July 1936. Specialization: Solid State Materials, Thin Film Technology and Thin Film Solar Cells Address: Honorary Emeritus Professor, Indian Institute of Engineering Science & Technology, Shibpur, Howrah 711 103, W.B.. Contact:

  6. Gurjar, Dr Mukund Keshao

    Indian Academy of Sciences (India)

    Gurjar, Dr Mukund Keshao Ph.D. (Nagpur and London), FNASc. Date of birth: 28 August 1952. Specialization: Carbohydrate Chemistry and Synthetic Organic Chemistry Address: Director, R&D, Emcure Pharmaceuticals Limited, P2, ITBT Park Phase II, Hinjwadi, Pune 411 057, Maharashtra Contact: Office: (020) 3982 1350, ...

  7. Techniques de l’ingénieur, a long-awaited resource

    CERN Multimedia

    GS Department

    2009-01-01

    Since 1 August 2009, a new online resource Les techniques de l’Ingénieur has been available at CERN: and its corpus of over 4,000 articles covering 11 disciplines is now accessible from your computer. This multidisciplinary database covers many subjects ranging from mechanics to the environment. The articles are written by scientific experts recognized in their fields. Online access includes the archives since 1946; it also serves to monitor the latest trends and innovations, and new industry products. This database is therefore both a valuable resource in past and present scientific and technological information and a tool to observe future developments. Anyone can create a free account on this resource. This account is needed to configure your personal alerts and download pdf files of the documents you are interested in. More information on the Library website. Direct access to the database

  8. Overall properties of the Gaia DR1 reference frame

    Science.gov (United States)

    Liu, N.; Zhu, Z.; Liu, J.-C.; Ding, C.-Y.

    2017-03-01

    Aims: The first Gaia data release (Gaia DR1) provides 2191 ICRF2 sources with their positions in the auxiliary quasar solution and five astrometric parameters - positions, parallaxes, and proper motions - for stars in common between the Tycho-2 catalogue and Gaia in the joint Tycho-Gaia astrometric solution (TGAS). We aim to analyze the overall properties of Gaia DR1 reference frame. Methods: We compare quasar positions of the auxiliary quasar solution with ICRF2 sources using different samples and evaluate the influence on the Gaia DR1 reference frame owing to the Galactic aberration effect over the J2000.0-J2015.0 period. Then we estimate the global rotation between TGAS with Tycho-2 proper motion systems to investigate the property of the Gaia DR1 reference frame. Finally, the Galactic kinematics analysis using the K-M giant proper motions is performed to understand the property of Gaia DR1 reference frame. Results: The positional comparison between the auxiliary quasar solution and ICRF2 shows negligible orientation and validates the declination bias of -0.1mas in Gaia quasar positions with respect to ICRF2. Galactic aberration effect is thought to cause an offset 0.01mas of the Z axis direction of Gaia DR1 reference frame. The global rotation between TGAS and Tycho-2 proper motion systems, obtained by different samples, shows a much smaller value than the claimed value 0.24mas yr-1. For the Galactic kinematics analysis of the TGAS K-M giants, we find possible non-zero Galactic rotation components beyond the classical Oort constants: the rigid part ωYG = -0.38±0.15mas yr-1 and the differential part ω^primeYG = -0.29±0.19mas yr-1 around the YG axis of Galactic coordinates, which indicates possible residual rotation in Gaia DR1 reference frame or problems in the current Galactic kinematical model. Conclusions: The Gaia DR1 reference frame is well aligned to ICRF2, and the possible influence of the Galactic aberration effect should be taken into consideration

  9. Nageswara Rao, Dr Gullapalli

    Indian Academy of Sciences (India)

    Nageswara Rao, Dr Gullapalli M.D. (Opthal.) (AIIMS), FAMS, FACS, FRCS, FNASc. Date of birth: 1 September 1945. Specialization: Cornea, Community Eye Health and Eye Care Policy & Planning Address: Distinguished Chair of Eye Health, LV Prasad Eye Institute, LV Prasad Marg, Banjara Hills, Hyderabad 500 034, A.P.

  10. Ghosh, Dr Pushpito Kumar

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2010 Section: Chemistry. Ghosh, Dr Pushpito Kumar Ph.D. (Princeton). Date of birth: 29 May 1954. Specialization: Processes Research, Water Purification, Renewable Energy, R&D Management Address: A-604, Punit Park, Plot No. 182/C, Sector 17, Merol, Navi Mumbai 400 706, ...

  11. Nandicoori, Dr Vinay Kumar

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2018 Section: General Biology. Nandicoori, Dr Vinay Kumar Ph.D. (IISc), FNASc. Date of birth: 1 March 1969. Specialization: Molecular & Cellular Biology, Cell Signalling, Cell Biology Address: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, U.T.; Contact ...

  12. Panda, Dr Subrat Kumar

    Indian Academy of Sciences (India)

    Panda, Dr Subrat Kumar M.B.B.S. (Utkal), M.D. (Path.) (AIIMS), FNA. Date of birth: 18 November 1954. Specialization: Liver Pathology, Viral Hepatitis and Molecular Biology/Virology Address: Professor, Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, U.T.. Contact:

  13. Basu, Dr Sandip Kumar

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1992 Section: General Biology. Basu, Dr Sandip Kumar Ph.D. (Calcutta), FNASc, FNA, FTWAS Council Service: 1995-97. Date of birth: 1 January 1944. Specialization: Cell Biology, Molecular Biology and Microbial Genetics Address: FD-426, Sector 3, Bidhan Nagar, Kolkata 700 106, W.B.. Contact:

  14. Workshop 3: Conformal Cooling with AM: Presentation held at International Workshop Additive Manufacturing: Ready for the Future? Innovative Solutions for Lightweight Design and Digital Manufacturing, 28. September 2017, Waterloo (Kanada)

    OpenAIRE

    Müller, Bernhard

    2017-01-01

    Bernhard Mueller graduated as »Dipl.-Ing.« in production engineering from Dresden University of Technology, Germany, in 1997 after preparing his final thesis at California State University, Long Beach (USA). He worked in German foundry and automotive supply industry for 12 years, focussing on R&D as well as on management responsibilities, serving as a plant manager in his latest position. In 2001, Bernhard obtained his »Dr.-Ing.« (PhD) degree from TU Dresden, Faculty of Mechanical Engineering...

  15. Improving an Empirical Formula for the Absorption of Sound in the Sea

    Science.gov (United States)

    2008-05-01

    Onderwater propagatie Advanced acoustic modelling Auteur (s) ir. C.A.M van Moll Programmanummer Projectnummer dr. M.A. Ainslie V512 032.11648 ing. J...versus calculated absorption .................................................................... 9 3 Inverse theory ...45 7.1 Statistical theory

  16. Measurement of radon exhalation rate in various building materials ...

    Indian Academy of Sciences (India)

    2Department of Physics, Dr. B.R. Ambedkar National Institute of Technology, Jalandhar, Punjab, India. ∗. Corresponding author. e-mail: ... ing the cement into the room air (Mustonen 1984). .... lected in clean, dry polyethylene bags from dif-.

  17. [Dr. Atanasije Puljo: pioneer of Serbian dentistry].

    Science.gov (United States)

    Jovananović, Svetlana; Milovanović, Srdjan; Zagradjanin, Danica; Milovanović, Nebojša; Puzović, Dragana

    2012-01-01

    This paper describes the life and work of Dr. Atanasije Puljo (1878-1944). He was a volunteer in the Balkan wars, an active participant in the First World War; he was the first who noted the importance of team-work of a dentist and a surgeon in the care of jaw and facial injuries. He established primacy in this field, as he came up with this brilliant idea three years before other colleagues. His method of treatment of the upper jaw neglected fractures, called the Balkan method, was recognized worldwide. Dr. Puljo is the pioneer of dental radiology in Serbia, founder of the Odontology Clinic of the Medical Faculty and main supporter of the establishment of the School of Dentistry. Merits of Dr. Atanasije Puljo, medical practitioner with a broad knowledge in different fields, remain within the academic institution that was founded by this pioneer of dentistry in Serbia.

  18. European Science Notes Information Bulletin: Reports on Current European/Middle Eastern Science

    Science.gov (United States)

    1992-06-01

    collaboration with DuPont, The researchers, Dr. C. Galiotis and Dr. C. Vlattas is exploiting the biodegradability of poly(lactides)! This (Queen Mary...state properties and crystal structures of Poly growth; novel morphology in ny’-n 46 leading to en- (L-lactides). This is an interesting biodegradable ...include ing of some spectacular movies illustrating the motion single crystals (B. Susla, Poznan Technical University of individual atoms on surfaces

  19. How Dr. Pierce Promoted Himself

    Data.gov (United States)

    Department of the Interior — This article is about Dr. Raymond V Pierce who owned St. Vincent Island before it became a refuge. The doctor painted advertisements for his famous “Woman’s Tonic”...

  20. Early onset of diabetes in the proband is the major determinant of risk in HLA DR3-DQ2/DR4-DQ8 siblings.

    Science.gov (United States)

    Gillespie, Kathleen M; Aitken, Rachel J; Wilson, Isabel; Williams, Alistair J K; Bingley, Polly J

    2014-03-01

    Islet autoimmunity is initiated in infancy, and primary prevention trials require children at high genetic risk to be identified before autoantibodies appear. To inform screening strategies, we evaluated risks of autoimmunity and diabetes associated with HLA DR3-DQ2/DR4-DQ8 in U.K. families. Extended HLA haplotypes were determined in 2,134 siblings from the Bart's-Oxford Study followed to a median age of 22 years. Risks of diabetes and islet autoimmunity (more than two antibodies) were estimated by survival analysis. Of 138 informative DR3-DQ2/DR4-DQ8 siblings, 63% shared both haplotypes with their diabetic proband, 29% shared one, and 8% shared neither. In HLA-identical DR3-DQ2/DR4-DQ8 siblings, the cumulative risk of diabetes by age 15 was 17% (vs. 6% in those sharing one haplotype or none; P = 0.095). Risk varied, however, with the age at the onset of diabetes in the proband; the cumulative risk of autoimmunity and/or diabetes by age 15 was 61% in siblings of probands diagnosed when younger than 10 years old compared with only 4.7% in those diagnosed after age 10 years (P sibling risk. This suggests that non-HLA genes or epigenetic/environmental factors that accelerate the progression of type 1 diabetes in the proband strongly affect risk in siblings.

  1. Should pediatric patients wait for HLA-DR-matched renal transplants?

    Science.gov (United States)

    Gritsch, H A; Veale, J L; Leichtman, A B; Guidinger, M K; Magee, J C; McDonald, R A; Harmon, W E; Delmonico, F L; Ettenger, R B; Cecka, J M

    2008-10-01

    Graft survival rates from deceased donors aged 35 years or less among all primary pediatric kidney transplant recipients in the United States between 1996 and 2004 were retrospectively examined to determine the effect of HLA-DR mismatches on graft survival. Zero HLA-DR-mismatched kidneys had statistically comparable 5-year graft survival (71%), to 1-DR-mismatched kidneys (69%) and 2-DR-mismatched kidneys (71%). When compared to donors less than 35 years of age, the relative rate of allograft failure was 1.32 (p = 0.0326) for donor age greater than or equal to age 35. There was no statistical increase in the odds of developing a panel-reactive antibody (PRA) greater than 30% at the time of second waitlisting, based upon the degree of HLA-A, -B or -DR mismatch of the first transplant, nor was there a 'dose effect' when more HLA antigens were mismatched between the donor and recipient. Therefore, pediatric transplant programs should utilize the recently implemented Organ Procurement and Transplantation Network's (OPTN)allocation policy, which prioritizes pediatric recipients to receive kidneys from deceased donors less than 35 years of age, and should not turn down such kidney offers to wait for a better HLA-DR-matched kidney.

  2. Dr. David Sawyer, Mickey Mouse and Dr. David Brown attend a ceremony at Ronald McNair Middle School

    Science.gov (United States)

    1999-01-01

    Dr. David Sawyer (left), Superintendent of the Brevard County School District, Mickey Mouse, and Dr. David Brown, a NASA astronaut, attend a tribute to NASA astronaut Ronald McNair held in the gymnasium of Ronald McNair Magnet School in Cocoa, Fla. During the tribute, Walt Disney World presented a portrait of McNair to the school, which had previously been renamed for the fallen astronaut. McNair was one of a crew of seven who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  3. Sirsat, Dr Satyavati Motiram

    Indian Academy of Sciences (India)

    Sirsat, Dr Satyavati Motiram Ph.D. (Mumbai). Date of birth: 7 October 1925. Date of death: 10 July 2010. Specialization: Medical Research (Cancer) & Ultrastructural Pathology and Hospice Care of the Dying Last known address: Bhagirathi Sadan, 17th Road, Khar, Mumbai 400 052. YouTube · Twitter · Facebook · Blog ...

  4. David, Dr Joy Caesarina

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1982 Section: Medicine. David, Dr Joy Caesarina M.B.B.S., M.S. (Madras). Date of birth: 3 May 1927. Date of death: 20 April 2004. Specialization: Neuropharmacology Last known address: 292, 4th Main, 1st Block, Koramangala, Bengaluru 560 034. YouTube; Twitter; Facebook ...

  5. Dr. Mostafa Moin, Minister of Science, Research and Technology, Islamic Republic of Iran

    CERN Multimedia

    Patrice Loïez

    2001-01-01

    L. to. r.:Dr Henrik Foeth, Team Leader, CMS experiment; Dr Daniel Denegri, Physics Coordinator, CMS experiment; Prof. Tejinder Virdee, Deputy Spokesman, CMS experiment; Prof. Luciano Maiani, CERN Director-General (signing); Mr Jean-Marie Dufour, Head of the Legal Service, Mr Ghodratollah Habibpour Gharakol (back); Dr Abdolali Sharghi, Advisor to the Minister and Director General, Office of International Scientific Cooperation, Ministry of Science, Research and Technology; Dr Mostafa Moin, Minister of Science, Research and Technology, Islamic Republic of Iran (signing); Dr Reza Mansouri, Director, International Scientific Meetings Office, Ministry of Science, Research and Technology; H. E. Dr Ali Khorram, Extraordinary and plenipotentiary Ambassador to the United Nations in Geneva and Dr Hans F. Hoffmann, CERN Director for Technology Transfer & for Scientific Computing. _

  6. Abd-Allah, Dr. Adel-Gamil

    African Journals Online (AJOL)

    Abd-Allah, Dr. Adel-Gamil. Vol 12, No 4 (2000) - Articles CORRELATION BETWEEN UTERINE ARTERY FLOW VELOCITY WAVEFORMS AND ENDOMETRIAL HISTOPATHOLOGY IN WOMEN WITH PERIMENOPAUSAL AND POSTMENOPAUSAL BLEEDING. Details. ISSN: 1110-5607. AJOL African Journals Online.

  7. Researcher Profile: An Interview With Dr. Rebecca J. Travnichek

    Directory of Open Access Journals (Sweden)

    Rebecca J. Travnichek

    2011-04-01

    Full Text Available

    Dr. Rebecca Travnichek is a Family Financial Education Specialist with University of Missouri Extension. Dr. Travnichek currently serves as the Annual Conference Program Chair. She is also very active in the Association for Financial Counseling and Planning Education, where she serves on the Board of Directors. Dr. Travnichek has participated in leadership development programs at the state and national levels. She was involved in the initial proposal development of the Financial Security for All Community of Practice with eXtension and continues to be involved through several roles. She is active in the National Extension Association of Family and Consumer Sciences at the national and state levels, serving in multiple leadership roles. For the past three years, Dr. Travnichek has also served as the Editor of the Journal of the National Extension Association of Family and Consumer Sciences. She represents the type of person who makes the Financial Therapy Association a dynamic organization linking practitioners and academicians.

  8. Through-Flow Calculations in Axial Turbomachinery

    Science.gov (United States)

    1976-10-01

    MEETING Dr Ing. G.Winterfeld, DFVLR, Germany PANEL EXECUTIVE Lt. Colonel J.B.Catiller, USAF - Meeting Organisation Dipl. Ing. J.H.Krengel, D.I.G...ralemenc subsonique. Ceci. ne veut d’ailleurs pas dire quo 10 problt~me du passage d’u-ne zone cupersonique A une zone subsonique ( chocs , blocago) se...ph~nom~nes tols que ci~collement, ondes do choc , etc... Nous avons v~rifi6 qu’une force do frottemont oppos~e A la viteese pout rernplir ce role sar.s

  9. The research contributions of Dr. Paul Van Deusen

    Science.gov (United States)

    Thomas B. Lynch; Francis A. Roesch; John Paul McTague; Jeffrey H. Gove; Gregory A. Reams; Aaron R. Weiskittel

    2015-01-01

    Dr. Paul Van Deusen’s recent passing concluded a rich 30+-year research career dedicated to development and implementation of quantitative methods for forestry and natural resources. Since the early part of his career as a biometrician with the USDA Forest Service Southern Research Station in the 1980s-1990s and continuing with his later employment at NCASI, Dr. Van...

  10. China's Investment Leade Dr, Alyce Su

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ I. Professional Background Dr. Alyce Su specializes in investment managemeng, managing portfolios consisted of investment opportunities originated from China's growth and internationalization, both'outbound and inbound.

  11. Drug: D08903 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available azole derivative See [DR:D00355] Non-erosive GERD, healing of erosive esophagitis, and maintenance of heal...ing of erosive esophagitis ATP4A [HSA:495] [KO:K01542]; ATP4B [HSA:496] [KO:K01543

  12. Energetics of lower tropospheric planetary waves over mid latitudes ...

    Indian Academy of Sciences (India)

    Indian Institute of Tropical Meteorology, Dr. Homi Bhabha Road, Pune 411 008, India. ∗ e-mail: ... port by wave 0 over southern equatorial belt dur- ing March leads to a ..... 2005a Contrasting features of wave number one during northern ...

  13. Value of HLA-DR genotype in systemic lupus erythematosus and lupus nephritis: a meta-analysis.

    Science.gov (United States)

    Niu, Zhili; Zhang, Pingan; Tong, Yongqing

    2015-01-01

    Human leukocyte antigen (HLA)-DRB1 allele polymorphisms have been reported to be associated with systemic lupus erythematosus (SLE) susceptibility, but the results of these previous studies have been inconsistent. The purpose of the present study was to systematically summarize and explore whether specific HLA-DRB1 alleles confer susceptibility or resistance to SLE and lupus nephritis. This review was guided by the preferred reporting items for systematic reviews and meta-analyses (PRISMA) approach. A comprehensive search was made for articles from PubMed, Medline, Elsevier Science, Springer Link and Cochrane Library database. A total of 25 case-control studies on the relationship between gene polymorphism of HLA-DRB l and SLE were performed and data were analyzed and processed using Review Manager 5.2 and Stata 11.0. At the allelic level, HLA-DR4, DR11 and DR14 were identified as protective factors for SLE (0.79 [0.69,0.91], P  0.05). DR4 and 11 (OR, 0.55 [0.39, 0.79], P  0.05; 0.90 [0.64, 1.27], P > 0.05; 0.61 [0.36, 1.03], P > 0.05, respectively) were not statistically significant between the lupus nephritis and control groups. The HLA-DR4, DR11, DR14 alleles might be protective factors for SLE and HLA-DR3, DR9, DR15 were potent risk factors. In addition, HLA-DR4 and DR11 alleles might be protective factors for lupus nephritis and DR3 and DR15 suggest a risk role. These results proved that HLA-DR3, DR15, DR4 and DR11 might be identified as predictors for lupus nephritis and SLE. © 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

  14. Treating Cataracts: Dr. Rachel Bishop's Top Tips for Your Eyes

    Science.gov (United States)

    ... please turn JavaScript on. Feature: Treating Cataracts Dr. Rachel Bishop's Top Tips for Your Eyes Past Issues / ... exams, a healthy lifestyle, and eye protection. Dr. Rachel Bishop, chief of consult services at the National ...

  15. Remaining Sites Verification Package for 132-DR-1, 1608-DR Effluent Pumping Station. Attachment to Waste Site Reclassification Form 2005-035

    International Nuclear Information System (INIS)

    Carlson, R.A.

    2005-01-01

    Radiological characterization, decommissioning and demolition of the 132-DR-1 site, 1608-DR Effluent Pumping Station was performed in 1987. The current site conditions achieve the remedial action objectives and the corresponding remedial action goals established in the Remaining Sites ROD. Residual concentrations support future land uses that can be represented by a rural-residential scenario and pose no threat to groundwater or the Columbia River based on RESRAD modeling

  16. Sproglige drømmerier

    DEFF Research Database (Denmark)

    Farø, Ken Joensen

    2015-01-01

    blev tidligere brugt i Danmarks Radio som pausesignal, afspillet på en spilledåse. Ak ja, det var dengang. Gå ind på nettet og lyt til den, hvis du ikke kender melodien. Det er national kulturarv. Mange bevingede ord indeholder en form af ”drøm(me)”, fx Martin Luther Kings ”I have a Dream”. Eller...

  17. Dr. Praveen Chaudhari named director of Brookhaven National Laboratory

    CERN Multimedia

    2003-01-01

    "Brookhaven Science Associates announced today the selection of Dr. Praveen Chaudhari as Director of the U.S. Department of Energy's Brookhaven National Laboratory. Dr. Chaudhari, who will begin his new duties on April 1, joins Brookhaven Lab after 36 years of distinguished service at IBM as a scientist and senior manager of research" (1 page).

  18. Murty, Dr Thutupalli Gopala Krishna

    Indian Academy of Sciences (India)

    Elected: 2002 Section: Engineering & Technology. Murty, Dr Thutupalli Gopala Krishna Ph.D. (Adelaide). Date of birth: 11 February 1944. Specialization: Optical Engineering, Thin Film Technology, Electro-Optical Instrumentation and Atmospheric Science Technologies Address: 848, 8th B Main, 17th Cross, ISRO Layout, ...

  19. 105-DR Large Sodium Fire Facility decontamination, sampling, and analysis plan

    International Nuclear Information System (INIS)

    Knaus, Z.C.

    1995-01-01

    This is the decontamination, sampling, and analysis plan for the closure activities at the 105-DR Large Sodium Fire Facility at Hanford Reservation. This document supports the 105-DR Large Sodium Fire Facility Closure Plan, DOE-RL-90-25. The 105-DR LSFF, which operated from about 1972 to 1986, was a research laboratory that occupied the former ventilation supply room on the southwest side of the 105-DR Reactor facility in the 100-D Area of the Hanford Site. The LSFF was established to investigate fire fighting and safety associated with alkali metal fires in the liquid metal fast breeder reactor facilities. The decontamination, sampling, and analysis plan identifies the decontamination procedures, sampling locations, any special handling requirements, quality control samples, required chemical analysis, and data validation needed to meet the requirements of the 105-DR Large Sodium Fire Facility Closure Plan in compliance with the Resource Conservation and Recovery Act

  20. SpoonEMF, une brique logicielle pour l'utilisation de l'IDM dans le cadre de la réingénierie de programmes Java5

    OpenAIRE

    Barais , Olivier

    2006-01-01

    2 ième Journée sur l'Ingénièrie Dirigée par les Modèles; Ce document présente succinctement SpoonEMF, une brique logicielle pour l'utilisation de l'IDM dans le cadre de la réingénierie d'applications écrites en Java. L'accent dans cette courte présentation est mis sur les cas d'utilisation possibles de cette brique logicielle et l'intérêt des choix techniques retenus : le framework EMF pour l'expression du méta-modèle afin de favoriser l'interopérabilité avec d'autres outils et l'intégration ...

  1. Analyize manifestations of DR and CT of 20 cases of bronchioloalveolar carcinoma

    International Nuclear Information System (INIS)

    Yang Zhongcheng

    2006-01-01

    Objective: Exploring the characters and changing rules between DR chest fluoroscopy and CT of bronchioloalveolar carcinoma. Methods: Collecting 20 cases DR chest fluoroscopies and CT scanning results of bron-chioloalveolar carcinoma, proved by biopsy, to reviewing analysis. Results: Bronchioloalveolar carcinoma divided into 3 types, nodular type, diffused type, infiltrated type. Nodular type focuses congregate and fused into node, density of the nodular shadow bad-distributed, vesical low-density shadow showed; Diffused type focus, multiple diffused nodish shadow gradually fused into patech consolidated shadow;Infiltrated focus distributed to pulmonary segment or lobes,like common pneumonia feature, existed airobronchogram, CT contrast scan shows typical 'CT angiogram'. Conclusion: No matter which type: nodular, diffused or infiltrated type, whose DR chest fluoroscopy and CT exists some features: Nodular type, DR chest fluoroscopy shows focuses mostly in periphery of pulmonary, margin with burr and plueral sunken sign, and whose HRCT manifestationshows typical small vesical sign in mediastinal window; Diffused type, DR chest fluoroscopy shows multiple diffused granular nodish shadow, however, CT manifestation can find more multiple focus than DR chest fluoroscopy, typical manifestation of HRCT is extensive small nodular shadow, with the thicken lobular interal; Infiltrated focus: DR chest fluoroscopy shows pulmonary consolidation and airobronchogram, And CT manifestations are CT angiogram and low-density consolidation shadow, wth specific property. Master all types of manifestation of DR and CT of bronchioloalveolar carcinoma, can help you improve the diagnosis of bronchioloalveolar carcinoma. (authors)

  2. Limited field investigation report for the 100-DR-1 Operable Unit

    International Nuclear Information System (INIS)

    1994-06-01

    This limited field investigation (LFI) report summarizes the data collection and analysis activities conducted during the 100-DR-1 Source Operable Unite LFI and the associated qualitative risk assessment (QRA), and makes recommendations on the continued candidacy of high-priority sites for interim remedial measures (IRM). The results and recommendations presented in this report are generally independent of future land use scenarios. The 100-DR-1 Operable Unit is one of four operable units associated with the 100 D/DR Area at the Hanford Site. The 100-DR-1 Operable Unit encompasses approximately 1.5 km 2 (0.59 mi 2 ) and is located immediately adjacent to the Columbia River shoreline. In general, it contains waste facilities associated with the original plant facilities constructed to support D Reactor facilities, as well as cooling water retention basin systems for both D and DR Reactors. The 100-DR-1 LFI began the investigative phase of the remedial investigation for a select number of high-priority sites. The LFI was performed to provide additional data needed to support selection, design and implementation of IRM, if needed. The LFI included data compilation, nonintrusive investigations, intrusive investigations, summarization of 100 Area aggregate studies, and data evaluation

  3. 105-DR large sodium fire facility closure Plan. Revision 2

    International Nuclear Information System (INIS)

    Ruck, F.A. III.

    1995-03-01

    The 105-DR Large Sodium Fire Facility (LSFF), which was operated 1972-1986, was a research laboratory that occupied the former ventilation supply room on the SW side of the 105-DR Reactor Facility. (The 105-DR defense reactor was shut down in 1964.) LSFF was used to investigate fire and safety aspects of large sodium or other metal alkali fires in the LMFBR facilities; it was also used to store and treat alkali metal waste. This closure plan presents a description of the unit, the history of the waste managed, and the procedures that will be followed to close the LSFF as an Alkali Metal Treatment Facility. No future use of LSFF is expected. It is located within the 100-DR-2 (source) and 100-HR-3 (groundwater) operable units, which will be addressed through the RCRA facility investigation/corrective measures study process

  4. DR AVRAM JOZEF VINAVER (1862-1915) - PIONEER OF RADIOLOGY IN SERBIA.

    Science.gov (United States)

    Babić, Rade Radomir; Stanković Babić, Gordana

    2015-01-01

    Dr Abraham Joseph Vinaver (1862-1915), a Jew from Poland, was a pioneer of radiology in Serbia. He graduated from the Faculty of Medicine in Warsaw (1887), but lived and worked in abac (the Kingdom of Serbia) since 1890. Dr Abraham Joseph Vinarev - Career Development. He procured the first X-ray machine and developed radiological service in Sabac five years after the discovery of X-rays. These were the beginnings of radiology in Serbia. He introduced the application of artesian wells. Dr Abraham Joseph Vinarev - a Participant at the First Congress of Serbian Physicians and Naturalists, Belgrade 1904. "The diagnostic importance of X-rays in lung disease, especially in initial tuberculosis" and "Five Years of Treatment by X-Ray Machines" were the first works in the field of radiology in Serbia by this author. Dr Abraham Joseph Vinaver - Reserve Medical Officer in the Serbian Army. During the Balkan Wars, he was a volunteer with the rank of major engaged in military corps and he participated in the First World War as well. He died of malaria in 1915 in Gevgelija. "Dr Avram Vinaver"- Stanislav Vinarev. His dedication to work during the typhus epidemics was put into verses of a poem by his son Stanislav Vinarev. Dr Avram Vinaver Joseph was a noble man with a great heart, who selflessly sacrificed himself for the Serbian people and Serbia. He gave his contribution to the development of health services in Serbia, both in peacetime and wartime conditions. Dr Abraham Joseph Vinaver laid the foundations for today's radiology in Serbia.

  5. Interview with Smithsonian NASM Spacesuit Curator Dr. Cathleen Lewis

    Science.gov (United States)

    Lewis, Cathleen; Wright, Rebecca

    2012-01-01

    Dr. Cathleen Lewis was interviewed by Rebecca Wright during the presentation of an "Interview with Smithsonian NASM Spacesuit Curator Dr. Cathleen Lewis" on May 14, 2012. Topics included the care, size, and history of the spacesuit collection at the Smithsonian and the recent move to the state-of-the-art permanent storage facility at the Udvar-Hazy facility in Virginia.

  6. The future of nursing: how important is discipline-specific knowledge? A conversation with Jacqueline Fawcett. Interview by Dr. Janie Butts and Dr. Karen Rich.

    Science.gov (United States)

    Fawcett, Jacqueline

    2012-04-01

    Nurses have long attempted to secure a unique identity for the profession. Many scholars are now promoting an interdisciplinary framework for nursing practice. Fawcett is convinced that interdisciplinary practice poses a danger for nursing to lose its identity and that interdisciplinary practice cannot be successful if members of each discipline do not understand the conceptual models, practice, and research of their own discipline. Dr. Janie Butts and Dr. Karen Rich interviewed Dr. Jacqueline Fawcett about her views related to discipline-specific knowledge and nursing's future. The authors conclude that Fawcett's scientific foundation gives nursing the solidarity and power necessary to determine the unique internal goods of its practice.

  7. Télécoms pour l’ingénierie du risque, Tullio Tanzi, Patrick Perrot

    Directory of Open Access Journals (Sweden)

    Jean-Baptiste Morin

    2013-04-01

    Full Text Available "Télécoms pour l’ingénierie du risque" est un ouvrage de 234 pages qui convoque la rencontre entre les Technologies de l’Information de la Communication (TIC et le risque. Les risques naturels, les risques industriels et technologiques ou encore les nouveaux risques générés par des usages déviants dans le domaine du numérique (cybercriminalité sont devenus monnaie courante. Les auteurs Tullio Tanzi (Professeur à Télécom ParisTech, département Traitement du Signal et des Images en télécommun...

  8. Data quality objectives summary report for the 100-BC-1, 100-BC-2, and 100-DR-1, and 100-DR-2 group 3 waste sites

    International Nuclear Information System (INIS)

    1997-03-01

    The 100-BC-1, 100-BC-2, 100-DR-1, and 100-DR-2 Group 3 waste sites contain 22 past-practice liquid waste disposal sites and process effluent piping associated with four plutonium-production nuclear reactors that operated from 1944 to 1967. The 100-BC-1, 100-BC-2, 100-DR-1, and 100-DR-2 Group 3 waste sites are the third set of Hanford 100 Area sites to undergo remediation to the extent practicable. Like the sites listed in Groups 1 and 2, the Group 3 sites are considered high-priority because of the contaminants present and their proximity to the Columbia River. Remediation of the 100-BC-1, 100-HR-1 and 100-DR-1 radioactive liquid waste sites is planned to occur in two phases: The first phase, which has been completed, was a demonstration project in the 100-B/C Area to test field techniques and acquire contamination data. The second phase is full-scale remediation of all the reactor areas, starting in the 10-B/C Area, using the field experience gained in the first phase and each subsequent reactor area remediation. This document provides the DQO in support of remediation sampling and analysis at selected sites in the 100-B/C and 100-D Areas

  9. DR. MIKA MAJALE MEMORIAL LECTURE

    African Journals Online (AJOL)

    He had four children Irene Majale,. Prof. Mike Majale (Architect) Victoria Majale Ojiambo and Chris Majale. Dr. Majale died on 21st April 1978. As an orthopaedic Surgeon he worked at Kenyatta. National Hospital (KNH), Kabete Orthopaedic Unit and. Armed Forces Memorial Hospital. He did not do any private practice.

  10. Ali, Dr Moizuddin Abdul Salim

    Indian Academy of Sciences (India)

    ... Section: Animal Sciences. Ali, Dr Moizuddin Abdul Salim D.Sc. (Andhra), D.Sc. (h.c.), FNA. Date of birth: 12 November 1896. Date of death: 20 June 1987. Specialization: Ecology, Zoogeography, Nature Conservation, Ornithology Last known address: No. 46, Pali Hill, Bombay 400 050. YouTube; Twitter; Facebook; Blog ...

  11. Separátory, sedimentační nádrže včetně funkce retenční nádrže Jeneweinova

    OpenAIRE

    Turic, Jakub

    2016-01-01

    Tato bakalářská práce se zabývá problematikou separátorů a sedimentačních nádrží, včetně funkce retenční nádrže Jeneweinova v Brně. Popisuje základní fyzikální a hydrodynamické vlastnosti vod a rozděluje její znečištění. Dále se zabývá popisem jednotlivých separačních a sedimentačních nádrží, jejich účel a využití. Zabývá se vznikem povodní a využití retenčních nádrží jako protipovodňové ochrany. Součástí práce je popis retenční nádrže Jeneweinova, její návrh, účel a funkce. The subject of...

  12. Raghavarao, Dr Karumanchi Srisaila Mallikarjuna S

    Indian Academy of Sciences (India)

    Elected: 2014 Section: Engineering & Technology. Raghavarao, Dr Karumanchi Srisaila Mallikarjuna S Ph.D. (Mumbai), FNAE, FNAAS. Specialization: Food Engineering, Biotechnology Address: Chief Scientist, Department of Food Engineering, Central Food Technological Research Institute, Mysore 570 020, Karnataka

  13. Dr. John Marburger visits DESY

    CERN Multimedia

    2003-01-01

    Dr. John Marburger, Director of the United States Office of Science and Technology Policy, visited the research center DESY in Hamburg. The American physicist wanted to inform himself about the status of the TESLA X-ray laser and the TESLA linear collider as well as the international collaboration at DESY (1/2 page).

  14. Den europæiske drøm - om EU

    DEFF Research Database (Denmark)

    Østergaard, Uffe

    2007-01-01

    Anmeldelse af: Jeremy Rifkin: Den europæiske drøm (Informations Forlag, 2006). Oversat fra engelsk efter: "The European Dream: How Europe's Vision of the Future Is Quietly Eclipsing the American Dream" (2004)......Anmeldelse af: Jeremy Rifkin: Den europæiske drøm (Informations Forlag, 2006). Oversat fra engelsk efter: "The European Dream: How Europe's Vision of the Future Is Quietly Eclipsing the American Dream" (2004)...

  15. Dr. David Syz, State Secretary for Economic Affairs, Switzerland

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Dr. David Syz, State Secretary for Economic Affairs, Switzerland is seen here (seventh from right) visiting the assembly hall for the ATLAS experiment during his recent visit to CERN. To his right is Dr. Peter Jenni (blue shirt), spokesperson for the ATLAS Collaboration. The horizontal metal cylinder behind the group is one of the eight vacuum vessels for the superconducting coils of the ATLAS barrel toroid magnet system.

  16. Celebrating the Life and Legacy of Dr. John Hope Franklin

    Science.gov (United States)

    Harris, Robert L., Jr.; Levering-Lewis, David; French, John D.; Wharton, Clifton R., Jr.

    2009-01-01

    Dr. John Hope Franklin chronicled the experiences of African-Americans like no one before him, forcing America to recognize Black history as American history. His contributions were innumerable and his impact was abiding. In celebration of his life and legacy, the authors profile the celebrated scholar and activist, Dr. John Hope Franklin.

  17. Dr Jacob van der Land, marine biologist extraordinary

    OpenAIRE

    Bruggen, van, A.C.

    2001-01-01

    This contribution is an attempt to sketch the life and works of Dr Jacob van der Land, curator of worms and chief marine biologist of the National Museum of Natural History, on the occasion of his official retirement. Born in 1935, Jacob van der Land read biology at Leiden University (1958-1964), where he obtained his Ph.D. in 1970 on a treatise on the Priapulida under the supervision of Prof. Dr L.D. Brongersma. In 1964 he was appointed curator of worms in the museum. Later on he took over l...

  18. Groener drogen

    NARCIS (Netherlands)

    Loman, N.G.M. (Niek)

    2012-01-01

    Auteur: N.G.M. (Niek) Loman Begeleiders: Ing. H.W. (Pim) van den Dool, Discrete Technologie en Productie Automatisering, RUG Dr.ir. I. (Ingrid) ten Have MBA, Interfac. Opleidingsinst. Technische Bedrijfskunde, RUG Drs. C.M. (Karin) Ree, Bèta Wetenschapswinkel, Science & Society Group, RUG Drs. R.W.

  19. CeasIng Cpap At standarD criteriA (CICADA): predicting a successful outcome.

    Science.gov (United States)

    Yin, Yue; Broom, Margaret; Wright, Audrey; Hovey, Donna; Abdel-Latif, Mohamed E; Shadbolt, Bruce; Todd, David A

    2016-01-01

    This is a retrospective analysis of a multicentre randomised controlled trial (RCT) where we concluded that CeasIng Cpap At standerD criteriA (CICADA) in premature babies (PBs) CPAP. To identify factors that may influence the number of attempts to cease CPAP, we reviewed the records of 50 PBs from the RCT who used the CICADA method. PBs were grouped according to number of attempts to cease CPAP (fast group ≤2 attempts and slow group >2 attempts to cease CPAP). There were 26 (fast group) and 24 (slow group) PBs included in the analysis. Results showed significant differences in mean GA (27.8 ± 0.3 vs 26.9 ± 0.3 [weeks ± SE], p = 0.03) and birth weight ([Bwt]; 1080 ± 48.8 vs 899 ± 45.8 [grams ± SE], p = 0.01) between groups. Significantly fewer PBs in the fast group had a patent ductus arteriosus (PDA) compared to the slow group (5/26 (19.2%) vs 13/24 (54.2 %), p = 0.02). Bwt was a significant negative predictor of CPAP duration (r = -0.497, p = 0.03) and CPAP ceasing attempts (r = -0.290, p = 0.04). PBs with a higher GA and Bwt without a PDA ceased CPAP earlier using the CICADA method. Bwt was better than GA for predicting CPAP duration and attempts to cease CPAP. Our previous studies showed that CeasIng Cpap At standarD criteriA (CICADA) significantly reduces CPAP time, oxygen requirements and caffeine use. Some PBs however using the CICADA method required >2 attempts to cease CPAP ('slow CICADA' group). PBs in the 'fast CICADA' group (CPAP) (a) have longer gestational age and higher birth weight, (b) shorter mechanical ventilation and (c) lower incidence of patent ductus arteriosus. Attempts to cease CPAP decreased by 0.5 times per 1 week increase in GA and 0.3 times per 100-g increase in birth weight for PBs <30 weeks gestation.

  20. The Honorable Dr Adolfo Urso, Vice Minister for Foreign Trade, "Viceministro delle Attivita' Produttive, Italia"

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Photo 01: The Honorable Dr Adolfo Urso, Deputy Minister for Productive Activities, Italy, visiting SM18 with (from l to r): Dr Roberto Saban, Technical Coordination and Planning, LHC machine; Prof. Luciano Maiani, CERN Director-General; Dr Mario Gerbino, Director General of the Ministry and Prof. Lucio Rossi, LHC Main Magnet and Superconductors (MMS) Group Leader. Photo 02: Prof. Luciano Maiani, CERN Director-General and The Honorable Dr Adolfo Urso, Deputy Minister for Productive Activities, Italy, in front of one of the LHC superconducting magnet in SM18. Photo 03 :In front of one of the LHC superconducting magnets - from left to right Dr Roberto Saban, Technical Coordination and Planning, LHC machine; The Honorable Dr Adolfo Urso, Deputy Minister for Productive Activities, Italy and Prof. Luciano Maiani, CERN Director-General. Photo 04: In the SM18 hall (from l. to r.) Prof. Luciano Maiani, CERN Director-General, The Honorable Dr Adolfo Urso, Deputy Minister for Productive Activities, Italy and Dr Mario Ge...

  1. An overview of the safety pharmacology career of Dr. C.R. Hassler.

    Science.gov (United States)

    Hawk, M A; Pugsley, M K; Vinci, T; Wallery, J; Hassler, C R; Hamlin, R L

    2017-09-01

    Each year the Safety Pharmacology Society (SPS) recognizes an investigator who has had a marked impact upon the discipline. The 2016 recipient of the SPS Distinguished Service Award (DSA) was Dr. Craig R. Hassler. Dr. Hassler is one of the founding members of the SPS and has been actively engaged in physiological research for over 46years. Dr. Hassler delivered a talk entitled "My 43Years at Battelle Memorial Institute" to meeting attendees. In this article an overview is provided of the illustrious career of Dr. Hassler along with an account of the numerous animal models that were developed at Battelle under his guidance over the years. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Influence of HLA-D/DR antigen disparity in CTL generation in vitro

    International Nuclear Information System (INIS)

    Johnsen, H.E.; Madsen, M.; Mossin, J.; Kristensen, T.

    1983-01-01

    This report describes the influence of HLA-D/-DR antigen disparity upon the level of cytotoxicity in allogeneic in vitro cultures. Allogeneic cultures, between unrelated HLA-D/-DR full house donors, tested in CML gave three different levels of cytotoxicity, termed weak, intermediate and strong cytotoxicity. HLA-D/-DR compatibility predicts weak cytotoxicity and two HLA-B antigen incompatibility predicts strong cytotoxicity. On the contrary, HLA-A antigens have no major influence upon the strength of cytotoxicity. Accepting that the MLC/CML reaction is an in vitro parallel to the in vivo transplantation of allogeneic tissue, the observations are in accordance with the results of HLA-D/-DR matching for graft survival in human renal transplantation. (author)

  3. Gaia DR1 documentation Chapter 6: Variability

    Science.gov (United States)

    Eyer, L.; Rimoldini, L.; Guy, L.; Holl, B.; Clementini, G.; Cuypers, J.; Mowlavi, N.; Lecoeur-Taïbi, I.; De Ridder, J.; Charnas, J.; Nienartowicz, K.

    2017-12-01

    This chapter describes the photometric variability processing of the Gaia DR1 data. Coordination Unit 7 is responsible for the variability analysis of over a billion celestial sources. In particular the definition, design, development, validation and provision of a software package for the data processing of photometrically variable objects. Data Processing Centre Geneva (DPCG) responsibilities cover all issues related to the computational part of the CU7 analysis. These span: hardware provisioning, including selection, deployment and optimisation of suitable hardware, choosing and developing software architecture, defining data and scientific workflows as well as operational activities such as configuration management, data import, time series reconstruction, storage and processing handling, visualisation and data export. CU7/DPCG is also responsible for interaction with other DPCs and CUs, software and programming training for the CU7 members, scientific software quality control and management of software and data lifecycle. Details about the specific data treatment steps of the Gaia DR1 data products are found in Eyer et al. (2017) and are not repeated here. The variability content of the Gaia DR1 focusses on a subsample of Cepheids and RR Lyrae stars around the South ecliptic pole, showcasing the performance of the Gaia photometry with respect to variable objects.

  4. Granice podmorskih prostora jadranskih država

    Directory of Open Access Journals (Sweden)

    Marina Vokić Žužul

    2015-09-01

    Full Text Available U ovome radu analiziraju se sve dosada utvrđene granice jadranskog podmorja kao i one koje tak valja utvrditi, posebice u svjetlu novih istraživanja njegovih prirodnih bogatstava. Uz Hrvatsku i Italiju, koje dijele najveći dio morskog dna i podzemlja u Jadranu, pravo na epikontinentski pojas imaju i Crna Gora te Albanija. Dvije jadranske države s kratkim obalama – Bosna i Hercegovina te Slovenija, države su u nepovoljnome geografskom položaju koje ne mogu imati epikontinentski pojas kao prirodni produžetak svoga kopnenog područja. Podmorski prostori tih država završavaju stoga na vanjskoj granici njihovih teritorijalnih mora. Osim razmatranja tih granica i sporazumno utvrđenih granica epikontinentskih pojaseva, autorice se kritički osvrću i na jednostrane akte Slovenije o proglašenju njezinoga epikontinentskog pojasa iz 2005. godine kao potpuno pravno neutemeljene akte. U središtu pozornosti ovoga rada je razmatranje granice koja dijeli podmorske prostore Hrvatske i Italije kao buduće granice dviju država i nad morskim dnom. Ta bi granična crta, u skladu s Konvencijom UN-a o pravu mora, trebala postati – jedinstvena morska granica njihovih epikontinentskih i gospodarskih pojaseva (odnosno ekološke zone Italije i zaštićenoga ekološko-ribolovnog pojasa Republike Hrvatske. Takva višefunkcionalna jedinstvena granična crta u najboljem je interesu pravne sigurnosti u svim načinima korištenja mora, a u međunarodnoj sudskoj i arbitražnoj praksi posljednjih desetljeća u potpunosti je zamijenila povlačenje različitih crta razgraničenja za više pojaseva u istome morskom prostoru. S obzirom na rezultate nedavno provedenih istraživanja potencijalnih nalazišta nafte i plina u južnom Jadranu, u radu se upozorava i na potrebu što skorijeg povlačenja crte bočnog razgraničenja epikontinentskih pojaseva Hrvatske i Crne Gore. Autorice analiziraju moguće pravce te nove granice, uzimajući u obzir znatno odstupanje od

  5. Evaluasi Fungsi Insinerator Dalam Memusnahkan Limbah B3 Di Rumah Sakit NI Dr.Ramelan Surabaya

    Directory of Open Access Journals (Sweden)

    Jahn Leonard Saragih

    2013-09-01

    Full Text Available Pengelolaan limbah padat B3 di Rumah Sakit TNI Angkatan Laut Dr. Ramelan sangat penting diperhatikan karena dapat berdampak buruk apabila tidak dikelola dengan baik. Oleh sebab itu diperlukan adanya penelitian untuk mengidentifikasi jumlah timbulan dan penanganan limbah padat B3, mengevaluasi manajemen, penyimpanan sementara serta mengevaluasi proses insinerasi. Evaluasi fungsi incinerator di Rumah Sakit TNI Angkatan Laut Dr. Ramelan dilakukan dengan meneliti jumlah timbulan limbah B3, kapasitas pembakaran insinerator, suhu pembakaran insinerator, densitas limbah dan abu pembakaran, dan tes TCLP residu pembakaran incinerator Rumah Sakit TNI Angkatan Laut Dr. Ramelan. Dalam penelitian ini, Rumkital Dr. Ramelan memusnahkan limbah dengan incinerator. Limbah B3 yang dihasilkan Rumkital Dr. Ramelan dimusnakan dengan satu incinerator dengan type KAMINE TYPE BDR-INC 10. Limbah yang dimusnahkan di Rumkital Dr. Ramelan berasal dari Rumkital Dr. Ramelan dan Lantamal Perak. Setelah dilakukan penelitian langsung selama 14 hari berturut-turut, didapatkan bahwa rata-rata timbulan limbah B3 di Rumkital Dr. Ramelan adalah 89.98 Kg/hari dan dengan densitas rata-rata limbah ialah 166,67 kg/m3. Tinggat removal dari pembakaran limbah dengan incinerator di Rumah Sakit TNI Angkatan Laut Dr. Ramelan ialah 82,63%. Pengelolaan abu sisa incinerator Rumkital Dr. Ramelan belum sesuai dengan peraturan yang berlaku dan dari penelitian yang dilakukan yaitu pengujian kandungan abu incinerator, solidifikasi abu incinerator dengan perbandingan semen:abu adalah 1:3 dan uji TCLP, didapatkan bahwa limbah abu sisa insinerator Rumah Sakit TNI Angkatan Laut Dr. Ramelan Surabaya, dapat ditimbun pada landfill kategori I sesuai dengan Keputusan Kepala Bapedal No.4 Tahun 1995.

  6. Decommissioning of DR 1, Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lauridsen, Kurt

    2006-01-15

    The report describes the decommissioning activities carried out at the 2kW homogeneous reactor DR 1 at Risoe National Laboratory. The decommissioning work took place from summer 2004 until late autumn 2005. The components with the highest activity, the core vessel the recombiner and the piping and valves connected to these, were dismantled first by Danish Decommissioning's own technicians. Demolition of the control rod house and the biological shield as well as the removal of the floor in the reactor hall was carried out by an external demolition contractor. The building was emptied and left for other use. Clearance measurements of the building showed that radionuclide concentrations were everywhere below the clearance limit set by the Danish nuclear regulatory authorities. Furthermore, measurements on the surrounding area showed that there was no contamination that could be attributed to the operation and decommissioning of DR 1. (au)

  7. Decommissioning of DR 1, Final report

    International Nuclear Information System (INIS)

    Lauridsen, Kurt

    2006-01-01

    The report describes the decommissioning activities carried out at the 2kW homogeneous reactor DR 1 at Risoe National Laboratory. The decommissioning work took place from summer 2004 until late autumn 2005. The components with the highest activity, the core vessel the recombiner and the piping and valves connected to these, were dismantled first by Danish Decommissioning's own technicians. Demolition of the control rod house and the biological shield as well as the removal of the floor in the reactor hall was carried out by an external demolition contractor. The building was emptied and left for other use. Clearance measurements of the building showed that radionuclide concentrations were everywhere below the clearance limit set by the Danish nuclear regulatory authorities. Furthermore, measurements on the surrounding area showed that there was no contamination that could be attributed to the operation and decommissioning of DR 1. (au)

  8. Tun Dr. Mahathir’s Leadership Communication: The Confucian Perspective

    Directory of Open Access Journals (Sweden)

    Cheah Joyce Lynn-Sze

    2017-01-01

    Full Text Available Previous studies have provided valuable insights into the impact of culture on the concept of leadership communication. However, only a few studies that focused on exploring and understanding the values of Confucianism and its impact on the Chinese culture, especially in Malaysia. Thus, this study is among the first study to examine the leadership communication from the perspective of Confucianism towards the leadership of Dr. Mahathir from the perspective of the Chinese community in Malaysia. This study aims to assess the role of Confucian values in Dr. Mahathir’s leadership communication. This study interviewed 15 Chinese leaders. The findings reveal that three main Confucian values are relevant to Dr. Mahathir’s leadership communication. The Confucian values are Zhi (wisdom, Xin (trust and Xiao (filial piety. This study provides a new perspective on leadership communication from the context of cultural diversity in Malaysia which emphasizes on Confucian values.

  9. DR2DI: a powerful computational tool for predicting novel drug-disease associations

    Science.gov (United States)

    Lu, Lu; Yu, Hua

    2018-05-01

    Finding the new related candidate diseases for known drugs provides an effective method for fast-speed and low-risk drug development. However, experimental identification of drug-disease associations is expensive and time-consuming. This motivates the need for developing in silico computational methods that can infer true drug-disease pairs with high confidence. In this study, we presented a novel and powerful computational tool, DR2DI, for accurately uncovering the potential associations between drugs and diseases using high-dimensional and heterogeneous omics data as information sources. Based on a unified and extended similarity kernel framework, DR2DI inferred the unknown relationships between drugs and diseases using Regularized Kernel Classifier. Importantly, DR2DI employed a semi-supervised and global learning algorithm which can be applied to uncover the diseases (drugs) associated with known and novel drugs (diseases). In silico global validation experiments showed that DR2DI significantly outperforms recent two approaches for predicting drug-disease associations. Detailed case studies further demonstrated that the therapeutic indications and side effects of drugs predicted by DR2DI could be validated by existing database records and literature, suggesting that DR2DI can be served as a useful bioinformatic tool for identifying the potential drug-disease associations and guiding drug repositioning. Our software and comparison codes are freely available at https://github.com/huayu1111/DR2DI.

  10. DR2DI: a powerful computational tool for predicting novel drug-disease associations

    Science.gov (United States)

    Lu, Lu; Yu, Hua

    2018-04-01

    Finding the new related candidate diseases for known drugs provides an effective method for fast-speed and low-risk drug development. However, experimental identification of drug-disease associations is expensive and time-consuming. This motivates the need for developing in silico computational methods that can infer true drug-disease pairs with high confidence. In this study, we presented a novel and powerful computational tool, DR2DI, for accurately uncovering the potential associations between drugs and diseases using high-dimensional and heterogeneous omics data as information sources. Based on a unified and extended similarity kernel framework, DR2DI inferred the unknown relationships between drugs and diseases using Regularized Kernel Classifier. Importantly, DR2DI employed a semi-supervised and global learning algorithm which can be applied to uncover the diseases (drugs) associated with known and novel drugs (diseases). In silico global validation experiments showed that DR2DI significantly outperforms recent two approaches for predicting drug-disease associations. Detailed case studies further demonstrated that the therapeutic indications and side effects of drugs predicted by DR2DI could be validated by existing database records and literature, suggesting that DR2DI can be served as a useful bioinformatic tool for identifying the potential drug-disease associations and guiding drug repositioning. Our software and comparison codes are freely available at https://github.com/huayu1111/DR2DI.

  11. Confessions of a Dr Math tutor

    CSIR Research Space (South Africa)

    Butgereit, L

    2015-06-01

    Full Text Available Mathematics look different on a small 3-inch screen of an inexpensive cell phone when compared to a 3-meter whiteboard in a mathematics classroom. Dr Math uses cell phone or mobile data "chat" technologies to assist primary and secondary school...

  12. Stop words for “Dr Math”

    CSIR Research Space (South Africa)

    Butgereit, L

    2011-05-01

    Full Text Available “Dr Math” is a facility where primary and secondary school pupils can use MXit on their cell phones to get help with their mathematics homework. Pupils use an abbreviated “MXit lingo” leaving out most vowels and substituting various numerals...

  13. Study on image quality and dosage comparison of F/S system and DR system

    International Nuclear Information System (INIS)

    Kim, Sun Chil; Jung, Jae Eun

    2003-01-01

    Currently, many hospital are hastening to introduce digital radiography systems. This is a direct result of the intentions to improve medical services and to digitalized radiology information systems, and is also leading to the improvement of medical imaging technology. Throughout F/S system's long history, many people have researched the image quality and dosage concerning these systems, and as a result, huge improvements in the dosage of patients were possible. Similarly, I believe that DR systems need the same kind of effort. Of course, decreases in dosage that ignore image quality are unthinkable. The results of experiments conducted by five hospitals during a period of 3 months brought to us the conclusions listed below. Based on the comparison and analysis of the exposure control of F/S systems and DR systems, DR systems generally showed higher exposure control for parts of the phantom that became thicker, and the exposure control improved rapidly as the thickness increased. DR systems still proved to be somewhat deficient in resolution measurements compared to existing F/S systems. The image processing part of DR systems contributed much to these result. Under conditions used clinically, the dosage measurements of DR systems were generally higher regardless of region. According to the evaluation of image quality, DR systems showed a higher degree of satisfaction as the thickness of the region became thinner. As mentioned above and based on the mutual relationship experiments between the dosage and image quality of F/S systems and DR systems, research to increase the satisfaction of DR systems must be considered

  14. Association of leprosy with HLA-DR2 in a Southern Brazilian population

    Directory of Open Access Journals (Sweden)

    Visentainer J.E.L.

    1997-01-01

    Full Text Available The association between HLA specificities and leprosy was investigated in a Southern Brazilian population. One hundred and twenty-one patients and 147 controls were typed for HLA-A, B, Cw, DR and DQ. Patients were subdivided into the following subgroups, according to clinical, histological and immunological criteria: lepromatous (N = 55, tuberculoid (N = 32, dimorphous (N = 20, and indeterminate (N = 14. The frequencies of HLA specificities were compared between the total group of patients and controls, and between the same controls and each subgroup of patients. After correction of the probabilities, deviations were not significant, except for the DR2 specificity, which presented a frequency of 44.2% in the total group of patients and 56.3% in the subgroup of individuals with the tuberculoid form of the disease, compared to 23.3% in the controls. Stratified analysis showed that the increased DR2 frequency in the total group of patients was due to the subgroups with the tuberculoid and dimorphous forms. The relative risk of tuberculoid leprosy for DR2-positive individuals was 4.2, and the etiologic fraction of DR2 was 0.429. In conclusion, a positive association of the DR2 specificity with the tuberculoid form of leprosy, but not with the lepromatous, dimorphous, or indeterminate forms, was demonstrated in this Southern Brazilian population

  15. Portrait of Dr. Von Braun with Walt Disney, 1954.

    Science.gov (United States)

    1954-01-01

    Marshall Center Director Dr. Wernher Von Braun is pictured with Walt Disney during a visit to the Marshall Space Flight Center in 1954. In the 1950s, Dr. Von Braun while working in California on the Saturn project, also worked with Disney studios as a technical director in making three films about Space Exploration for television. Disney's tour of Marshall in 1965 was Von Braun's hope for a renewed public interest in the future of the Space Program at NASA.

  16. Dr. Lindberg's Legacy : Charting A New Course | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... more. Don also created the National Center for Biotechnology Information (NCBI). NCBI has been a focal point ... with Dr. Lindberg (right) and National Center for Biotechnology Information Director Dr. David Lipman (center) at a ...

  17. 2700-IJBCS-Article-Dr Matar Seck

    African Journals Online (AJOL)

    hp

    of Maytenus senegalensis in the management of sickle cell disease. © 2016 International ... En plus de l'anémie, la vaso-occlusion, résultant de la ... crises de douleur, de la fièvre et des douleurs ... vaso-occlusives dans la drépanocytose. Ces.

  18. Practitioner Profile: An Interview with Dr. Jerry Gale, LMFT

    Directory of Open Access Journals (Sweden)

    Jerry Gale

    2012-06-01

    Full Text Available Dr. Jerry Gale is an Associate Professor and the Clinical Director of the Marriage and Family Therapy Doctoral Program at the University of Georgia. He is a Licensed Marriage and Family Therapist and an approved supervisor of the American Association of Marriage and Family Therapists. He earned a B.A. from the University of Michigan, a MEd from the University of Arizona, and a Ph.D. from Texas Tech University. Over the course of his career, Dr. Gale has authored three books and over 60 articles and book chapters. He is a co-developer of a relational financial therapy approach that combines financial counseling with family therapy and has extensive training in clinical hypnosis, couples therapy, and family therapy, as well as mindfulness meditation. He is the recipient of the American Family Therapy Academy 2006 Outstanding Research Award. In addition to his work at the University of Georgia, Dr. Gale conducts therapy at Athens Associates for Counseling and Psychotherapy.

  19. 105-DR Large Sodium Fire Facility closure plan

    International Nuclear Information System (INIS)

    1993-05-01

    The Hanford Site, located northwest of the city of Richland, Washington, houses reactors, chemical-separation systems, and related facilities used for the production of special nuclear materials, and activities associated with nuclear energy development. The 105-DR Large Sodium Fire Facility (LSFF), which was in operation from about 1972 to 1986, was a research laboratory that occupied the former ventilation supply room on the southwest side of the 105-DR Reactor facility. The LSFF was established to provide a means of investigating fire and safety aspects associated with large sodium or other metal alkali fires in the liquid metal fast breeder reactor (LMFBR) facilities. The 105-DR Reactor facility was designed and built in the 1950's and is located in the 100-D Area of the Hanford Site. The building housed the 105-DR defense reactor, which was shut down in 1964. The LSFF was initially used only for engineering-scale alkali metal reaction studies. In addition, the Fusion Safety Support Studies program sponsored intermediate-size safety reaction tests in the LSFF with lithium and lithium lead compounds. The facility has also been used to store and treat alkali metal waste, therefore the LSFF is subject to the regulatory requirements for the storage and treatment of dangerous waste. Closure will be conducted pursuant to the requirements of the Washington Administrative Code (WAC) 173-303-610. This closure plan presents a description of the facility, the history of waste managed, and the procedures that will be followed to close the LSFF as an Alkali Metal Treatment Facility. No future use of the LSFF is expected

  20. Comparative study between rib imaging of DR dual energy subtraction technology and chest imaging

    International Nuclear Information System (INIS)

    Yu Jianming; Lei Ziqiao; Kong Xiangchuang

    2006-01-01

    Objective: To investigate the application value of DR dual energy subtraction technology in rib lesions. Methods: 200 patients were performed with chest DR dual energy subtraction, comparing the rib imaging between DR of thorax and chest imaging using ROC analysis. Results: Among the total of 200 patients, there are 50 cases of rib calcification, 7 cases of rib destruction, 22 cases of rib fracture. The calcification, destruction and fracture were displayed respectively by ribs below diaphragm and rib markings. The analytic parameter of rib imaging of DR dual energy subtraction Az is 0.9367, while that of rib imaging of chest Az is 0.6830. Conclusion: DR dual energy subtraction technology is superior to chest imaging in the displaying of rib lesion and ribs below diaphragm. (authors)

  1. Dr. Tulga Ersal at NSF Workshop Accessible Remote Testbeds ART'15

    Science.gov (United States)

    Event Archives Dr. Tulga Ersal at NSF Workshop Accessible Remote Testbeds ART'15 On November 12th, Dr Workshop on Accessible Remote Testbeds (ART'15) at Georgia Tech. From the event website: The rationale behind the ART'15 workshop is that remote-access testbeds could, if done right, significantly change how

  2. Spre[ing amelanotic malignant melanoma: A rare differential diagnosis with tumors of the glandula submandibularis

    International Nuclear Information System (INIS)

    Ehrenberg, C.; Helmberger, H.

    1998-01-01

    The case reported emphasizes the importance of immediate performance of imaging scans in case of the slightest suspicion that clinical symptoms might indicate malignancy of a detected lesion. Despite the superficially only marginal macroscopic findings, MR imaging as well as the CT scans revealed an [vanced, malignant process that h[ been spre[ing. Particularly the soft tissue differential diagnosis obtained with MRI yields the information required for diagnostic characterization of the space occupying tumor mass. It will however be necessary in any case to verify the diagnosis by biopsy or extirpation and cytologic examination of tissue, as the imaging methods do not always unambigiously reveal the malignant dignity of the tumor. (orig./CB) [de

  3. Gaia: Mapping the Milky Way: The Scientific Promise of Gaia DR2

    Science.gov (United States)

    Walton, Nicholas; ESA Gaia, Data Processing and Analysis Consortium (DPAC)

    2018-06-01

    The ESA Gaia mission will release its first major all sky astrometric catalogue (Gaia DR2), of more than 1.3 billion stars in our Galaxy, on 25 April 2018.This presentation will provide an overview of the Gaia mission, focussing on the significant scientific potential of the Gaia DR2 release. This is based on 22 months of input data and allows for a full Gaia stand alone astrometric solution, including parallaxes and proper motions, of over 1.3 billion sources. The astrometric uncertainties in Gaia DR2 will be at the level of tens of micro-arcsec for sources Gproducts including the light curves of more than half a million variable stars, and the positions of more than thirteen thousand objects in our Solar System.Together with the Gaia DR2 data products and associated release documentation, a small number of performance verification papers, using Gaia DR2 data only to provide new insights into a number of key areas of Gaia science, will be published in a special edition of A&A. These will provide demonstrations of the scientific potential of the Gaia DR2 catalogue, and also highlight some of the issues and limitations involved in the use of the Gaia DR2 data.The Gaia mission and Gaia Data Releases are made possible through the dedication and expertise of the community scientists and engineers involved in the design, construction, and operation of Gaia (led by ESA) and the collaboration of some 450 scientists and software engineers responsible for the complex task of analysing the processed data (the DPAC). The role of both will be covered in the presentation.The presentation will conclude with a brief look ahead to the longer term Gaia data release schedule.

  4. Mida teed siis, kui töötaja on avaldanud soovi firmast lahkuda? / Inge Rumessen, Andres Hall, Mariliin Saar ... [jt.

    Index Scriptorium Estoniae

    2016-01-01

    Küsimusele vastavad PR Strategies partner ja strateegiline konsultant Inge Rumessen, auto24ring juhataja Andrs Hall, vabakutseline loovjuht ja produtsent Mariliin Saar, advokaadibüroo Tark partner Hannes Küün, ettevõtte Ööloom ja Frank kaasasutaja Jan Plaan, haridus- ja teadusministeeriumi personaliosakonna juhataja Margot Saluse, Sorry as Service müügijuht ja asutaja Indrek Põldvee ja EBS-i rahvusvahelise koostöö prorektor Toomas Danneberg

  5. Tales of Recombinant Femininity: "The Reincarnation of Golden Lotus," the "Chin P'ing Mei," and the Politics of Melodrama in Hong Kong.

    Science.gov (United States)

    Fore, Steve

    1993-01-01

    Examines the film "The Reincarnation of Golden Lotus" and the text upon which it is loosely based, the "Chin P'ing Mei," and the relationship between it and modern Chinese culture. States that the film's screenplay is much less an adaptation of the source novel than it is a female-centered reworking of a particular narrative…

  6. Dr. Ding Hou 80 years young

    NARCIS (Netherlands)

    Baas, Pieter; Adema, Frits

    2001-01-01

    Eleven October 2001 is the 80th birthday of Dr. Ding Hou, much appreciated Honorary Staff Member of our Nationaal Herbarium Nederland. Time to reflect on the life and career of this modest but highly productive and talented botanist. Ding Hou was born in 1921 in Hsingkan, Kiangsi Province, China.

  7. Drømmefabrikken

    Directory of Open Access Journals (Sweden)

    Paulo Affonso Grisolli

    1994-09-01

    Full Text Available Som mangeårig producent af telenovelaer både i Brasilien og Portugal, kender Grisolli alle sider af telenovelaen: Novelaen som de fattiges drøm om rigdom og succes, novelaen som et redskab i TV-kanalernes kamp om seerne, som exportvare, som glansbillede under det brasillianske dik- tatur, som industriprodukt og som politisk igangsætter. I denne artikel be- skriver Grisolli sine erfaringer med gode og dårlige sider af telenovela- fascinationen i Latinamerika og præsenterer en ny genre, som er på vej frem i Brasilien, mini-serien. Artiklen er Grisollis foredrag på Folkekirkens Nødhjælps Konference om TV og Video i Latinamerika, november 1992.

  8. The life and contribution of Dr. Ronald Gitelman: a pioneer of modern chiropractic science.

    Science.gov (United States)

    Vernon, Howard

    2013-03-01

    The life and contribution to chiropractic science of Dr. Ronald Gitelman is reviewed. Sources for this article included review of the notes prepared by Dr. Joseph Keating in his "biography" of the Canadian Memorial Chiropractic College (CMCC); review of the important articles published by Dr. Gitelman; review of the important projects undertaken by him along with various colleagues; notes from reminiscences obtained from many of these colleagues and discussions with his family. Dr. Gitelman's academic career spanned from 1963 to the late 1980's. During that time, he made foundational contributions to the development of chiropractic science including: developing the Archives (1974), the first collection of scientific articles supporting chiropractic science (which was subsequently published as the Chiropractic Archives Research Collection (CRAC)); delivering one of the few chiropractic papers at the seminal NINCDS conference (1975) and, developing the collaboration between CMCC and Dr. Kirkaldy-Willis at the University of Saskatoon (1976). He practiced in Toronto from 1961 to 2007. Dr. Gitelman was a pioneer in the development of chiropractic science. He died on October 7, 2012.

  9. [Sexuality education on the Internet : From Dr. Sommer to Dr. Google].

    Science.gov (United States)

    Döring, Nicola

    2017-09-01

    Female and male adolescents in Germany are increasingly using the Internet to find information about sexuality and sexual health. This review paper summarizes what we know about the status quo of online sexuality education in Germany.Based on a systematic literature review including 40 papers from international, peer-reviewed journals spanning 2010-2017, this paper first describes different aspects of the sexuality-related online search behavior of adolescents: its prevalence, predictors, topics and contexts. One main finding is the fact that adolescents use a computer or smartphone to type their sexuality-related questions into the search engine Google or the search engine of the video platform YouTube.Based on 54 online searches, this paper subsequently presents the kind of sexuality-related online content adolescents find if they ask "Dr. Google" for sexual advice; a collection of 1236 authentic sexuality-related questions of adolescents was used for this analysis. It turned out that online sexuality education offered by leading professional organizations like the BZgA ("Bundeszentrale für gesundheitliche Aufklärung") or pro familia was nearly invisible, while numerous other providers of online sex education consistently appeared in the top Google search results. Among them were the "Dr. Sommer" team of the youth magazine Bravo; online healthcare and advice portals; online forums; the online encyclopedia Wikipedia and, above all, sex education channels on YouTube. In this paper, the latter are presented in more detail for the first time.The third part of the paper addresses the quality of online sexual education over four main areas of quality evaluation. The presentation of the status quo ends with some recommendations both for future research and for sexuality education in practice.

  10. Clinical evaluation of diuretic renography in infants and children with congenital urinary abnormality

    International Nuclear Information System (INIS)

    Li Jingsong; Li Jianing; Fu Hongliang; Zou Renjian; Wu Jingchuan

    2006-01-01

    Objective: The clinical application of furosemide plus 15-minute diuretic renography (F+15 DR) was evaluated in infants and children with congenital urinary abnormalities. Methods: In 163 patients with different congenital urinary abnormalities undergoing F+15 DR, 97 were operated and followed by F+15 DR reexamination. The DR imaging characteristics were analyzed and, based on those analyses, hydronephrosis was classified into five degrees. Follow-up data were analyzed both quantitatively and qualitatively. Results: Each renal abnormality (kidney duplication 60, horseshoe kidney 6, multiple cysts of kidney 5, hypoplasia 35, ureterocele 20, displacement of ureter opening 13, megaloureter 20, valve of ureter 26) exhibited its unique characteristics on DR imaging. Renal functions of those patients were improved dur- ing the follow-up after surgical operations. Patients with duplex kidney and ureter abnormalities had better prognosis than those with urethral valve. Conclusion: F + 15 DR imaging may reveal characteristic changes of congenital urinary abnormalities and helps in the qualitative or quantitative evaluation of the treatments. (authors)

  11. Words of gratitude to Dr. Michel Huguet

    International Nuclear Information System (INIS)

    Yoshikawa, Masaji

    2003-01-01

    It is impossible for the Japanese fusion community, in particular for those associated with the ITER Project,to hear about the retirement of Dr. Michel Huguet without a great amount of gratitude, recollections, warm feelings, and the inevitable sadness. He was a first-generation ITER EDA person. Three months after the signing of the ITER EDA Agreement in July 1992, he arrived at the Naka Joint Work Site as Deputy Director of the ITER Central Team and Head of the site and he stayed for more than ten years. The Naka site was for design and technical co-ordination in the areas of magnets, plasma control and heating, plant systems, buildings, etc. Dr. Huguet was considered a highly qualified person to fill the position, since he had been successful as Deputy Director in similar areas in the JET Joint Undertaking. During the ITER EDA he co-ordinated the R and D activities in areas for which the Naka Joint Work Site was responsible. These R and D results permitted the completion of the ITER design in the above areas under his supervision. We thank Dr. Huguet for his achievements and contributions to ITER. He played a crucial role in establishing the convincing scientific and technical basis for ITER implementation. This was only made possible by his broad abilities and his dedication to the cause of fusion in general and ITER in particular

  12. HLA-DR-specific suppressor cells after repeated allogeneic sensitizations of human lymphocytes in vitro

    International Nuclear Information System (INIS)

    Sasportes, M.; Fradelizi, D.; Dausset, J.

    1978-01-01

    In conclusion, DR-specific suppressor cells can be induced by repeated in vitro sensitizations. They were able to decrease a secondary proliferation, to suppress consistently, in a primary proliferative assay, when added as third cells (primed twice against a DR antigen [PLT II] and γ-irradiated), the response of unprimed cells towards stimulating cells, which share a DR specificity with the priming cell of the PLT II. The suppression follows the D part of the recombinant haplotype within an HLA-B/D recombinant family and is specific for the DR antigen used twice as stimulator for production of the PLT II

  13. Desalination - A source of water supply | Yehuda | Zede Journal

    African Journals Online (AJOL)

    A talk Delivered on May 29th, 1964, before the Ethiopian Association of Engineers and Architects. After expressing his gratitude, joy and pride at being called upon to deliver the first lecture to the Ethiopian Association of Engineers and Architects, Professor Dr. - Ing. Y ehuda Peter introduced his lecture by recalling his ...

  14. Aircraft Fire Safety held in Sintra (Portugal) on 22-26 May 1989

    Science.gov (United States)

    1989-10-01

    Ankara, Turkey Cranfleld, Bedford MK43 OAL, UK Mr J.F.Cheva]ier Dr C.A.Moses Ing~nieur en Chef - Recherches Director, Department of Energy SNECMA...evacuation trials, there was a number of instances of affiliative behavior, i.e. friends and family did not evacuate untill they had found their companions

  15. Dr. Francis Collins Is New NIH Director

    Science.gov (United States)

    ... Ph.D., a physician and geneticist, is the new Director of the National Institutes of Health (NIH), part of the U.S. Department of Health and Human Services. President Barack Obama nominated Dr. Collins, who served as Director of ...

  16. EDITORIAL, FOREWORD

    Directory of Open Access Journals (Sweden)

    Editorial Foreword

    2017-06-01

    Full Text Available Biomaterials and SurfacesSeptember 20th-23th, 2016Herbertov, Czech RepublicOrganized by:Department of Materials Engineering, Faculty of Mechanical Engineering, Czech Technical University in PragueInstitute of Rock Structure and Mechanics AS CRSociety for composite and carbon materialsGuest editor: Ing. Zdeněk ToldeThe colloquium "Biomaterials and surfaces" focuses on methods for biocompatibility testing and methods for characterization and modification of biomaterials and their surfaces. The goal of this seminar is to inform the participants about fundamental problematic of biomaterials and the recent state of research and development of prostheses or artificial replacements in Czech Republic. At the seminar, participants and students are meeting with the scientific capacities in the field of biomaterials and surfaces (materials engineering, medicine, physics, chemistry, biology and with the experts from practice (doctors, representatives of leading Czech companies in the industry.Scientific comitee:Doc. RNDr. Vladimír Starý CSc. (Faculty of Mechanical EngineeringIng. Karel Balík, CSc. (Society for composite and carbon materialsIng. Tomáš Suchý Ph.D. (Institute of Rock Structure and Mechanics AS CR Ing. Radek Sedláček Ph.D. (Faculty of Mechanical Engineering Ing. Zdeněk Tolde (Faculty of Mechanical EngineeringGuarantors of peer review process: Prof. RNDr. Petr Špatenka CSc. (Faculty of Mechanical Engineering Doc. RNDr. Vladimír Starý CSc. (Faculty of Mechanical Engineering Ing. Tomáš Suchý Ph.D. (Institute of Rock Structure and Mechanics AS CR Doc. RNDr. Václav Nehasil, Dr. (Faculty of Mathematics and Physics RNDr. Marta Vandrovcová, Ph.D. (Institute of Physiology CAS Guarantor of language editing:Ing. Stanislav Krum PhD.Organizing comitee: Ing. Karel Balík, CSc. RNDr. Martin Braun, Ph.D. Ing. Ladislav Cvrček Ph.D. Ing. Zdeňka Jeníková Ph.D. Ing. Radek Sedláček Ph.D. Doc. RNDr. Vladimír Starý CSc. Ing. Tomáš Such

  17. In Memoriam Dr. J. H. Kern

    NARCIS (Netherlands)

    Kalkman, C.

    1974-01-01

    On 29 July 1974 dr. J. H. Kern died at the age of 70. At the occasion of his official retirement from the Rijksherbarium staff (January 1969) Van Steenis and Van Ooststroom gave due recognition to his achievements in tropical botany and to his share in the progress of the knowledge of the Dutch

  18. Identification and distribution of three serologically undetected alleles of HLA-DR by oligonucleotide x DNA typing analysis

    International Nuclear Information System (INIS)

    Tiercy, J.M.; Gorski, J.; Jeannet, M.; Mach, B.

    1988-01-01

    Recent progress in the molecular biology of human major histocompatibility complex class II genes (HLA-DP, -DQ, -DR) have shown that the genetic complexity and allelic polymorphism are greater than expected. In the case of HLA-DR, three DR β-chain loci have been identified and linked, two of which (DR βI and DR βIII, now assigned names HLA-DR1B and HLA-DR3B) are functional. The authors have shown that the HLA micropolymorphism detected at the DNA sequence level can easily be analyzed by hybridization with allele-specific oligonucleotides (HLA oligotyping). In the case of the HLA DRw52 supertypic specificity, which includes the DR3, DR5, DRw6, and DRw8 haplotypes, three alleles, referred to as DRw52a, DRw52b, and DRw52c, have recently been identified at the HLA-DR3B locus by DNA sequencing. Hybridization with locus- and allele-specific oligonucleotide probes (designated 52a, 52b, and 52c) has been performed on DNA from normal individuals forming a panel of 82 haplotypes to establish the distribution of these three alleles. Individuals of the DR3 haplotype had either the DRw52a or DRw52b allele, and individuals of extended haplotype HLA-A1,B8,DR3 had only the DRw52a allele. DR5 individuals all had the DRw52b allele, while individuals of DRw6 haplotype had the DRw52a, -52b, or -52c allele. None of these three alleles are found in DRw8 individuals. Analysis of this micropolymorphism, undetectable by common typing procedures, is therefore now operational for more accurate HLA matching for transplantation and for improving correlations between HLA and disease susceptibility

  19. The ING observatory in the 2015-2025 decade

    Science.gov (United States)

    Balcells, M.

    2015-05-01

    The Isaac Newton Group, after nearly 30 years of productive operation of the William Herschel, Isaac Newton and Jacobus Kapteyn telescopes, is reviewing its science focus. The central goal is to respond to the changes in the astronomical landscapes in UK, the Netherlands, and especially in Spain, now a mature world-player community with access to 10-m class telescopes on La Palma and Paranal. The current model, which exploits scientific and instrumentation diversity, will continue to be offered until 2017. In the meantime, an ING-led consortium is building WEAVE, a next-generation spectroscopic facility for the WHT. WEAVE is a multi-fibre system capable of deploying either 1000 single-fibre probes, 25 mini-IFUs or a single large IFU, to feed a two-arm bench spectrograph which delivers resolving powers of either 5000 or 20,000. WEAVE will exploit a new field corrector at the WHT that enlarges the prime-focus FOV diameter from the current 40 arcmin to 2 degrees. WEAVE will be used to carry out massive surveys that exploit Gaia data in topics of Milky Way astronomy and stellar evolution; surveys that carry out galaxy evolution studies linked to various multi-wavelength surveys, including the LOFAR radio telescope; and redshift surveys of distant galaxies for cosmology. Community fibres will be available. The expectation is that these surveys will use 70% of the WHT time until at least 2022. The rest of the time will be available via normal TAC allocations, for use of facility instrumentation. Plans for the INT include involving external institutions in the provision of new instrumentation and/or telescope upgrades in exchange for significant fractions of telescope time.

  20. Intra HLA-D/DR region recombinant detected by primed lymphocyte typing (PLT)

    DEFF Research Database (Denmark)

    Jakobsen, B K; Kristensen, T; Lamm, L U

    1983-01-01

    lymphocyte typing (PLT) for HLA-D/DR region associated DP antigens. None of these studies gave evidence that the recombinations had occurred within the HLA region. Mixed leucocyte culture (MLC) tests within the families showed no detectable stimulation between the HLA identical siblings in two......The chromosome 6 markers, HLA-ABC, D, DR, MT, properdin factor Bf, and complement factors 2 (C2) and 5 (C4), were studied in three families, each of which included two HLA identical siblings, one or both of whom were known to be HLA-B: GLO recombinants. The families were also typed with primed...... to reactive reagents. One of these (GHx), reacted with a determinant which segregated within the GG family as if child G was a paternal recombinant between the HLA-D, DR, DP, and C4 loci, on the one hand, and on the other hand one or more loci governing other HLA-D/DR region controlled lymphocyte activating...

  1. Visit of H.E. Dr Abdolrahim Gavahi, Secretary General, Economic Cooperation Organization, Islamic Republic of Iran

    CERN Multimedia

    Patrice Loïez

    2001-01-01

    Photo 01: L.to r. Prof. Galileo Violini, Head, UNESCO Office, Teheran; Mr Jan van der Boon, CERN Director of Administration; H.E. Dr Abdolrahim Gavahi, Secretary General, Economic Cooperation Organization, Islamic Republic of Iran (signing the Guest Book); Dr John Ellis, CERN Adviser for Non-Member State Relations and Dr Behzad Alipour Tehrany Photo 02: Mr Jan van der Boon, CERN Director of Administration (left) and Dr John Ellis, CERN Adviser for Non-Member State Relations (right) on the occasion of the visit of H.E. Dr Abdolrahim Gavahi, Secretary General, Economic Cooperation Organization, Islamic Republic of Iran.

  2. Reminiscences by Dr. I.I. Rabi

    International Nuclear Information System (INIS)

    Rabi, I.I.

    1973-01-01

    Dr. I.I. Rabi, Professor of Physics, Columbia University, Nobel Laureate, adviser to presidents and an original member of the scientific advisory committees both of the United Nations and the IAEA, delivered the following address at the Salazar Atomic Centre, Mexico, in October 1972 he spoke on 'reminiscences from scientific advisory services to governments and international organizations'. (author)

  3. Running injuries and associated factors in participants of ING Taipei Marathon.

    Science.gov (United States)

    Chang, Wei-Ling; Shih, Yi-Fen; Chen, Wen-Yin

    2012-08-01

    To investigate the distribution of lower extremity running injuries and their associated factors. Descriptive and exploratory study. 1004 participants of the 2005 ING Taipei International Marathon. We used a self-developed questionnaire to collect data of previous running injuries and applied multivariate logistic regression modeling to examine relationships between these injuries and associated factors. Of the 893 valid questionnaires, 396 (44.4%) reported having previous lower extremity pain related to running. Knee joint pain was the most common problem (32.5%). Hip pain was associated with the racing group, training duration, and medial arch support. Use of knee orthotics (P = 0.002) and ankle braces (P = 0.007) was related to a higher rate of knee and ankle pain. Participants of the full marathon group who practiced on a synthetic track had a higher incidence of ankle pain. A training duration of >60 min was linked to an increased rate of foot pain (P = 0.003). Our data indicated that running injuries were associated with training duration and use of orthotics. Clinicians can use this information in treating or preventing running associated injuries and pain. Copyright © 2011 Elsevier Ltd. All rights reserved.

  4. Agonistic Human Monoclonal Antibodies against Death Receptor 4 (DR4) | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The National Cancer Institute is seeking parties interested in licensing human monoclonal antibodies (mAbs) that bind to death receptor 4 ("DR4"). The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and its functional receptors, DR4 and DR5, have been recognized as promising targets for cancer treatment.

  5. White dwarf-main sequence binaries from LAMOST: the DR5 catalogue

    Science.gov (United States)

    Ren, J.-J.; Rebassa-Mansergas, A.; Parsons, S. G.; Liu, X.-W.; Luo, A.-L.; Kong, X.; Zhang, H.-T.

    2018-03-01

    We present the data release (DR) 5 catalogue of white dwarf-main sequence (WDMS) binaries from the Large Area Multi-Object fiber Spectroscopic Telescope (LAMOST). The catalogue contains 876 WDMS binaries, of which 757 are additions to our previous LAMOST DR1 sample and 357 are systems that have not been published before. We also describe a LAMOST-dedicated survey that aims at obtaining spectra of photometrically-selected WDMS binaries from the Sloan Digital Sky Survey (SDSS) that are expected to contain cool white dwarfs and/or early type M dwarf companions. This is a population under-represented in previous SDSS WDMS binary catalogues. We determine the stellar parameters (white dwarf effective temperatures, surface gravities and masses, and M dwarf spectral types) of the LAMOST DR5 WDMS binaries and make use of the parameter distributions to analyse the properties of the sample. We find that, despite our efforts, systems containing cool white dwarfs remain under-represented. Moreover, we make use of LAMOST DR5 and SDSS DR14 (when available) spectra to measure the Na I λλ 8183.27, 8194.81 absorption doublet and/or Hα emission radial velocities of our systems. This allows identifying 128 binaries displaying significant radial velocity variations, 76 of which are new. Finally, we cross-match our catalogue with the Catalina Surveys and identify 57 systems displaying light curve variations. These include 16 eclipsing systems, two of which are new, and nine binaries that are new eclipsing candidates. We calculate periodograms from the photometric data and measure (estimate) the orbital periods of 30 (15) WDMS binaries.

  6. Dr.Zhang Ren's Experience in Acupuncture Treatment of Obstinate Eye Diseases

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Dr.Zhang Ren (張仁), the board chairman of Shanghai Acupuncture Association, has been engaging in acupuncture treatment for more than 30years, during which he has kept on exploring the acupuncture therapies for obstinate diseases,especially for the obstinate eye diseases, ant summed up rich experience in this aspect. The following is a summary of what the author has learned from Dr. Zhang Ren.

  7. [Dr Guillermo Contreras Da Silva, a relevant figure in the development of Chilean microbiology].

    Science.gov (United States)

    Cabello, Felipe C

    2008-02-01

    The influence of the work of Dr. Guillermo Contreras Da Silva and his colaborators on the evolution of microbiology in Chile is briefly analyzed. Dr. Contreras was trained in modern virology at Yale University with Dr. J. Melnick under the sponsorhip of the Rockefeller Foundation. During this training, he used serological methods to classify Cocksakie viruses. After his return to Chile, he studied the epidemiology of enteroviruses, including poliovirus. His laboratory, the country's first in modern virology, took an active role in Chile's first Sabin polio vaccination in 1961. Dr. Contreras and his group transformed the teaching and the character of microbiology in Chile from a descriptive medically oriented discipline into an autonomous, quantitative and experimental science. They modernized microbiology with the introduction of molecular biology and microbial genetics and fostered collaborations with allied biological sciences. Dr. Contreras was a Guggenheim Fellow, and until his retirement, was the Chief of the Viral Products Division, Bureau of Biologies, Ottawa, Canada.

  8. Evolution and current status of demand response (DR) in electricity markets: Insights from PJM and NYISO

    International Nuclear Information System (INIS)

    Walawalkar, Rahul; Fernands, Stephen; Thakur, Netra; Chevva, Konda Reddy

    2010-01-01

    In electricity markets, traditional demand side management programs are slowly getting replaced with demand response (DR) programs. These programs have evolved since the early pilot programs launched in late 1990s. With the changes in market rules the opportunities have generally increased for DR for participating in emergency, economic and ancillary service programs. In recent times, various regulators have suggested that DR can also be used as a solution to meet supply - demand fluctuations in scenarios with significant penetration of variable renewable sources in grid. This paper provides an overview of the evolution of the DR programs in PJM and NYISO markets as well as analyzes current opportunities. Although DR participation has grown, most of the current participation is in the reliability programs, which are designed to provide load curtailment during peak days. This suggests that there is a significant gap between perception of ability of DR to mitigate variability of renewables and reality of current participation. DR in future can be scaled to play a more dynamic role in electricity markets, but that would require changes both on technology as well as policy front. Advances in building technologies and energy storage combined with appropriate price signals can lead to enhanced DR participation. (author)

  9. His Excellency Professor Dr Che-Ho Wei, Chairman, National Science Council Executive Yuan, Republic of China

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Photo 01: Professor Dr. Che-Ho Wei signing the Guest Book with CERN Director-General, L. Maiani. Photo 02: Professor Dr. Che-Ho Wei. Photo 03::Professor Dr. Che-Ho Wei shaking hands with CERN Director-General, L. Maiani.

  10. Characteristics of Rheumatoid Arthritis relative to HLA-DR in Saudi Arabia

    International Nuclear Information System (INIS)

    Al-Arfaj, Abdurhman S.

    2001-01-01

    The objective was to determine the clinical characteristics of rheumatoid arthritis in Saudi Arabia in relation to human leukocyte antigen type. A group of 91 rheumatoid arthritis patients, 72 females and 19 males were studied for the various clinical, laboratory and radiological parameters along with human leukocyte antigen-DR phenotypes. Since human leukocyte antigen-DR10 was most commonly associated with rheumatoid arthritis in our population, we compared those patients with human leukocyte antigen-DR10 to those without. The comparison yielded differences in the presence of rheumatoid nodules, erosions, corticosteroid treatment, and joint involvement at presentation, hemoglobin levels, and white cell count. Only the last 3 parameters showed a statistical significance. Human leukocyte antigen type of Saudi patients with rheumatoid arthritis influenced the course of the disease but only to a limited extent. (author)

  11. Loss and benefit of DR system in mass screening for upper GI-tracts. Comparison with an II-TV based DR system and 100-mm roll-film system

    International Nuclear Information System (INIS)

    Ogura, Toshihiro; Fujita, Hiroshi.

    1995-01-01

    A 2048 x 2048 matrix II-TV based digital radiography (DR) system, a fully digital imaging system with diagnosis on the CRT monitor, had been introduced to Cancer Institute Hospital for the GI-tracts examinations since January 1990. Furthermore, we had applied it to the mass screening of upper GI-tract since November 1992. In the present study, a retrospective study on clinical evaluation and features of the DR system for the mass screening were investigated and compared with the screening data taken by conventional 100-mm roll-film technique in the previous year. The loss ratios and appearance of the mucosal patterns in upper gastric images were studied as well. Also determined was the reading time of those images in the mass screening situation. It was found that the loss ratio on the subject image information in 100-mm roll-film images was smaller than that in DR images. However, the DR images processed by windowing technique provided the perfect information without partially over or under density area. It was shown that the clinical image quality greatly depended on the radiographic technique by radiologists or technologists rather than on the imaging modality itself employed; even in II/TV-DR system, the radiographic technique is important. Because of some issues, including the size of CRT monitor, eyestrain for CRT monitor, and windowing operation regard to reading system, the reading time of CRT images was 1.44-2.05 times longer than that of 100-mm roll-film images. (author)

  12. High Temperature Superconductors: From Delivery to Applications (Presentation from 2011 Ernest Orlando Lawrence Award-winner, Dr. Amit Goyal, and including introduction by Energy Secretary, Dr. Steven Chu)

    International Nuclear Information System (INIS)

    Goyal, Amit

    2012-01-01

    Dr. Amit Goyal, a high temperature superconductivity (HTS) researcher at Oak Ridge National Laboratory, was named a 2011 winner of the Department of Energy's Ernest Orlando Lawrence Award honoring U.S. scientists and engineers for exceptional contributions in research and development supporting DOE and its mission. Winner of the award in the inaugural category of Energy Science and Innovation, Dr. Goyal was cited for his work in 'pioneering research and transformative contributions to the field of applied high temperature superconductivity, including fundamental materials science advances and technical innovations enabling large-scale applications of these novel materials.' Following his basic research in grain-to-grain supercurrent transport, Dr. Goyal focused his energy in transitioning this fundamental understanding into cutting-edge technologies. Under OE sponsorship, Dr. Goyal co-invented the Rolling Assisted Bi-Axially Textured Substrate technology (RABiTS) that is used as a substrate for second generation HTS wires. OE support also led to the invention of Structural Single Crystal Faceted Fiber Substrate (SSIFFS) and the 3-D Self Assembly of Nanodot Columns. These inventions and associated R and D resulted in 7 R and D 100 Awards including the 2010 R and D Magazine's Innovator of the Year Award, 3 Federal Laboratory Consortium Excellence in Technology Transfer National Awards, a DOE Energy100 Award and many others. As a world authority on HTS materials, Dr. Goyal has presented OE-sponsored results in more than 150 invited talks, co-authored more than 350 papers and is a fellow of 7 professional societies.

  13. Successful Collaborations with Dr. S. Raman in Research on Nuclear Data in Japan

    International Nuclear Information System (INIS)

    Mizumoto, Motoharu

    2005-01-01

    Since the early 1970s, Dr. Raman visited Japan many times and established a good and fruitful relationship with many scientists from universities and institutions in Japan. Many Japanese scientists, in particular young researchers, also worked together with him at Oak Ridge National Laboratory (ORNL). Through this successful collaboration, we made various achievements in the nuclear data and nuclear physics fields. Japanese researchers all remember Dr. Raman as a very active and warmhearted person. In this paper, some of the results that Dr. Raman established by collaborating with Japanese scientists will be presented

  14. Dr. Andrew Foster: A Literature Review

    Science.gov (United States)

    Runnels, Joel

    2017-01-01

    Often compared to Laurent Clerc, Thomas Gallaudet, and Alexander Graham Bell, Dr. Andrew Foster was a deaf African American who founded 32 schools for the deaf in 13 African nations. The 60th anniversary of his arrival in Liberia and Ghana and the 30th anniversary of his tragic death in a Rwanda airplane accident both occur in 2017. Renewed…

  15. The Dr-nanos gene is essential for germ cell specification in the planarian Dugesia ryukyuensis.

    Science.gov (United States)

    Nakagawa, Haruka; Ishizu, Hirotsugu; Chinone, Ayako; Kobayashi, Kazuya; Matsumoto, Midori

    2012-01-01

    Homologs of nanos are required for the formation and maintenance of germline stem cell (GSC) systems and for gametogenesis in many metazoans. Planarians can change their reproductive mode seasonally, alternating between asexual and sexual reproduction; they develop and maintain their somatic stem cells (SSCs) and GCSs from pluripotent stem cells known as neoblasts. We isolated a nanos homolog, Dr-nanos, from the expressed sequence tags (ESTs) of the sexualized form of Dugesia ryukyuensis. We examined the expression of Dr-nanos in asexual and sexualized planarians by in situ hybridization and analyzed its function using RNA interference (RNAi) together with a planarian sexualization assay. A nanos homolog, Dr-nanos, was identified in the planarian D. ryukyuensis. Dr-nanos expression was observed in the ovarian primordial cells of the asexual worms. This expression increased in proportion to sexualization and was localized in the early germline cells of the ovaries and testes. In X-ray-irradiated worms, the expression of Dr-nanos decreased to a large extent, indicating that Dr-nanos is expressed in some subpopulations of stem cells, especially in GSCs. During the sexualization process, worms in which Dr-nanos was knocked down by RNAi exhibited decreased numbers of oogonia in the ovaries and failed to develop testes, whereas the somatic sexual organs were not affected. We conclude that Dr-nanos is essential for the development of germ cells in the ovaries and testes and may have a function in the early stages of germ cell specification, but not in the development of somatic sexual organs.

  16. Dr. Ted Trimble: Why I Do Cancer Research

    Science.gov (United States)

    In a video, Dr. Ted Trimble talks about the importance of cancer research. World Cancer Research Day commemorates the important role research and cancer researchers play in reducing the global burden of cancer.

  17. Chamber of Commerce reception for Dr. Lucas

    Science.gov (United States)

    1986-01-01

    Dr. William R. Lucas, Marshall's fourth Center Director (1974-1986), delivers a speech in front of a picture of the lunar landscape with Earth looming in the background while attending a Huntsville Chamber of Commerce reception honoring his achievements as Director of Marshall Space Flight Center (MSFC).

  18. Annotated Bibliography of Dr Salmani Nodoushan's Research on Education and Language Teaching

    Science.gov (United States)

    Etemadfar Kashani, Abbas Ali

    2016-01-01

    This is an annotated bibliography of the research conducted on education and language teaching and assessment by Dr. Mohammad Ali Salmani Nodoushan in the past 25 years. This bibliography is a precise picture of the current state of education and language teaching and assessment in Iran. Dr. Salmani Nodoushan is the most distinguished Iranian…

  19. Human radiation studies: Remembering the early years. Oral history of Dr. Nadine Foreman, M.D., August 19, 1994

    International Nuclear Information System (INIS)

    1995-07-01

    Dr. Nadine Foreman was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). Dr. Foreman was selected for interview because of the position she held at the University of California, San Francisco. Following a brief biographical sketch, Dr. Foreman describes her work with Dr. Mayo Soley using I-131 in treatment of hyperthyroidism, selection criteria for patients in the radioiodine project, work with Dr. Earl Miller, work at Highland Hospital, radioiodine treatment of diffuse toxic goiter (myxedema), the radiophosphorus and radioiodine programs with Dr. Bert Low-Beer, and treatment of polycythemia vera

  20. Human radiation studies: Remembering the early years. Oral history of Dr. Nadine Foreman, M.D., August 19, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    Dr. Nadine Foreman was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). Dr. Foreman was selected for interview because of the position she held at the University of California, San Francisco. Following a brief biographical sketch, Dr. Foreman describes her work with Dr. Mayo Soley using I-131 in treatment of hyperthyroidism, selection criteria for patients in the radioiodine project, work with Dr. Earl Miller, work at Highland Hospital, radioiodine treatment of diffuse toxic goiter (myxedema), the radiophosphorus and radioiodine programs with Dr. Bert Low-Beer, and treatment of polycythemia vera.

  1. Doppler transcranien au cours de la drépanocytose chez l'enfant Malagasy

    Science.gov (United States)

    Herinirina, Nicolas Fanantenana; Rajaonarison, Lova Hasina Ny Ony Narindra; Herijoelison, Andry Roussel; Rakoto, Olivat Aimée Alson; Ahmad, Ahmad

    2016-01-01

    Introduction Le doppler transcrânien est un outil efficace permettant de dépister les enfants drépanocytaires à risque d'AVC. Méthodes Nous avons réalisé une étude descriptive transversale sur des enfants Malagasy âgés entre 24 mois et 15 ans (groupe 1: 57 drépanocytaires, groupe 2: 43 témoins) afin d’évaluer le profil vélocimétrique des artères cérébrales chez les drépanocytaires. Un examen Doppler transcrânien a été réalisé avec étude des flux sanguins cérébraux chez les enfants des deux groupes. Résultats Pour les sujets drépanocytaires, la vitesse moyenne (VM) de l'artère cérébrale moyenne était de 100,9 ± 26,8 cm/s, l'indice de pulsatilité (IP) de 0,73 ± 0,20, la différence entre les artères cérébrales moyennes droite et gauche (ACMr) de 19,8 ± 21,5 cm/s, le rapport des vitesses de l'artère cérébrale antérieure/artère cérébrale moyenne (ACA/ACM) de 0,7 ± 0,2. Pour les enfants non drépanocytaires, VM: 80,6 ± 19,3 cm/s, IP: 0,79 ± 0,14, ACMr: 17 ± 20,1 cm/s, ACA/ACM: 0,8 ± 0,2. La vélocité des enfants drépanocytaires était supérieure au groupe contrôle. Les vitesses ont été corrélées avec le taux d'hémoglobine et l’âge et non pas avec le sexe et le volume globulaire moyen. Conclusion Les vitesses circulatoires cérébrales sont élevées chez les drépanocytaires que les enfants non drépanocytaires et sont influencées par le taux d'hémoglobine et l’âge. PMID:27516829

  2. An evaluation of calculation procedures affecting the constituent factors of equivalent circulating density for drilling hydraulics

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, William J.

    1996-12-31

    This Dr. ing. thesis covers a study of drilling hydraulics offshore. The purpose of drilling hydraulics is to provide information about downhole pressure, suitable surface pump rates, the quality of hole cleaning and optimum tripping speeds during drilling operations. Main fields covered are drilling hydraulics, fluid characterisation, pressure losses, and equivalent circulating density. 197 refs., 23 figs., 22 tabs.

  3. An evaluation of calculation procedures affecting the constituent factors of equivalent circulating density for drilling hydraulics

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, William J

    1997-12-31

    This Dr. ing. thesis covers a study of drilling hydraulics offshore. The purpose of drilling hydraulics is to provide information about downhole pressure, suitable surface pump rates, the quality of hole cleaning and optimum tripping speeds during drilling operations. Main fields covered are drilling hydraulics, fluid characterisation, pressure losses, and equivalent circulating density. 197 refs., 23 figs., 22 tabs.

  4. Sleep and Alertness Management II: Effects on Sleep Pattern and Sleep Quality in Marmosets (slaap- en alertheidsmanagement II: effecten op slaapritme en slaapkwaliteit in marmosetapen)

    Science.gov (United States)

    2006-10-01

    beleidsondersteuning Commando Luchtstrijdkrachten/Hoofd Auteur (s) Afdeling Gezondheidszorg operaties dr. I.H.C.H.M. Philippens, R.A.P. Vanwersob, ing. M.J... Theory .......................................................................................................................... 9 2.1 Sleep as an...2 Theory 2.1 Sleep as an active and rhythmical process Till the 50s the research on sleep was dominated by a passive theory of sleep. This theory

  5. Pengaruh Proses Pelapukan Clay Shale terhadap Perubahan Parameter Rasio Disintegritas (DR

    Directory of Open Access Journals (Sweden)

    Idrus M Alatas

    2017-04-01

    Full Text Available The background of this research because of the frequent occurrence of the failure in the geotechnical design of clay shale caused by weathering. Disintegration ratio is a comparison of physical changes due to weathering at certain times of the initial conditions. Changes in physical properties due to clay shale weathering determined by the disintegration ratio (DR.Clay shale weathering will occur more quickly as a result of wetting and drying cycles when compared with the drying process. While due to the increased number of cycles of wetting at the same time, causing weathering on clay shale will be faster again. Until the 80th day of drying time, the magnitude DRof Semarang-Bawenclay shaleand Hambalang are the same, namely DR = 0.916 (completelly durable. However, due to wetting and drying cycles on day 32, samples of Semarang-Bawenclay shale is DR = 0.000 or non durable completelly, while on Hambalang clay shale in same day DR between 0.2117 to 0.3344. Generally Semarang-Bawen clay shale will be faster weathered than Hambalang clay shale. It is caused by the mineralogy content of Semarang-Bawen clay shale has dominated by Smectite, and Hambalangclay shalehas dominated mineral Kaolinite and Illlite.

  6. Glaucoma: Eye-to-Eye with Dr. Rachel Bishop

    Science.gov (United States)

    ... of this page please turn JavaScript on. Feature: Glaucoma Eye-to-Eye with Dr. Rachel Bishop Past ... nerves are pale and cupped—signs of advanced glaucoma. Yet the patient wasn't aware of any ...

  7. Dr. William O. Coffee and his absorption cure for cataract.

    Science.gov (United States)

    Ferry, A P

    1989-08-01

    Dr. William O. Coffee was an ophthalmologist who conducted an office and mail-order practice in the Midwest from the 1880s until 1927. His main stock in trade was a self-discovered absorption cure for a variety of ocular diseases, with particular emphasis on the medical cure of cataracts. Dr. Coffee's career was a checkered one, marked by dubious credentials, exuberant self-promotion, unlikely and exaggerated claims of medical successes, plagiarism, and rejection by the medical "establishment." Certain parallels may be drawn between his activities and some currently observed practices in ophthalmology.

  8. Finance computationnelle et gestion des risques ingénierie financière avec applications Excel (Visual Basic) et Matlab

    CERN Document Server

    Racicot, François-Éric

    2006-01-01

    Ce manuel propose un exposé rigoureux de la gestion des risques en finance. Les aspects théoriques de la question sont abordés par des démonstrations claires et des rappels élaborés des bases mathématiques de la finance computationnelle. Le texte est émaillé de nombreux programmes écrits en langages Visual Basic (Excel), Matlab et EViews qui prépareront l'étudiant à sa carrière de spécialiste en ingénierie financière.

  9. Generation of functional HLA-DR*1101 tetramers receptive for loading with pathogen or tumour derived synthetic peptides

    Directory of Open Access Journals (Sweden)

    Protti Maria

    2005-12-01

    Full Text Available Abstract Background MHC class I-peptide tetramers are currently utilised to characterize CD8+ T cell responses at single cell level. The generation and use of MHC class II tetramers to study antigen-specific CD4+ T cells appears less straightforward. Most MHC class II tetramers are produced with a homogeneously built-in peptide, reducing greatly their flexibility of use. We attempted the generation of "empty" functional HLA-DR*1101 tetramers, receptive for loading with synthetic peptides by incubation. No such reagent is in fact available for this HLA-DR allele, one of the most frequent in the Caucasian population. Results We compared soluble MHC class II-immunoglobulin fusion proteins (HLA-DR*1101-Ig with soluble MHC class II protein fused with an optimised Bir site for enzymatic biotynilation (HLA-DR*1101-Bir, both produced in insect cells. The molecules were multimerised by binding fluorochrome-protein A or fluorochrome-streptavidin, respectively. We find that HLA-DR*1101-Bir molecules are superior to the HLA-DR*1101-Ig ones both in biochemical and functional terms. HLA-DR*1101-Bir molecules can be pulsed with at least three different promiscuous peptide epitopes, derived from Tetanus Toxoid, influenza HA and the tumour associated antigen MAGE-3 respectively, to stain specific CD4+ T cells. Both staining temperature and activation state of CD4+ T cells are critical for the binding of peptide-pulsed HLA-DR*1101-Bir to the cognate TCR. Conclusion It is therefore possible to generate a soluble recombinant HLA-DR*1101 backbone that is receptive for loading with different peptides to stain specific CD4+ T cells. As shown for other HLA-DR alleles, we confirm that not all the strategies to produce soluble HLA-DR*1101 multimers are equivalent.

  10. When Cathy Was a Little Girl: The Healing "Praxis" of Tarot Images

    Science.gov (United States)

    Semetsky, Inna

    2010-01-01

    This paper is a sequel to an earlier article that presented an argument for Tarot symbolic system functioning as a "techne" that can serve as a valuable educational aid. The present paper shifts the focus from "techne" to "praxis" as a practical art of interpreting images and creating imaginative narratives in the context of counselling and…

  11. [Homage to Professor Dr. Nicasio Etchepareborda].

    Science.gov (United States)

    1998-11-01

    During a solemn academic act, de Main Classroom of the Facultad de Odontologia de Buenos Aires was named after Prof. Dr. Nicasio Etchepareborda. He has been the first professor at the Escuela de Odontologia and its organizer, after having obtained his Dentistry degree at the Dental School of Paris, in 1882. The new school was founded in 1891, and its activities began the following year.

  12. Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions

    Directory of Open Access Journals (Sweden)

    Furuya Toshio

    2011-02-01

    Full Text Available Abstract Background The amount of data on protein-protein interactions (PPIs available in public databases and in the literature has rapidly expanded in recent years. PPI data can provide useful information for researchers in pharmacology and medicine as well as those in interactome studies. There is urgent need for a novel methodology or software allowing the efficient utilization of PPI data in pharmacology and medicine. Results To address this need, we have developed the 'Druggable Protein-protein Interaction Assessment System' (Dr. PIAS. Dr. PIAS has a meta-database that stores various types of information (tertiary structures, drugs/chemicals, and biological functions associated with PPIs retrieved from public sources. By integrating this information, Dr. PIAS assesses whether a PPI is druggable as a target for small chemical ligands by using a supervised machine-learning method, support vector machine (SVM. Dr. PIAS holds not only known druggable PPIs but also all PPIs of human, mouse, rat, and human immunodeficiency virus (HIV proteins identified to date. Conclusions The design concept of Dr. PIAS is distinct from other published PPI databases in that it focuses on selecting the PPIs most likely to make good drug targets, rather than merely collecting PPI data.

  13. Typing for HLA-D/DR associated DP-antigens with the primed lymphocyte typing (PLT) technique

    DEFF Research Database (Denmark)

    Morling, N; Jakobsen, B K; Platz, P

    1980-01-01

    A total of 74 healthy unrelated random individuals and 36 patients with juvenile rheumatoid arthritis (JRA) were typed for HLA-D antigens with the homozygous typing cell technique and typed for HLA-D/DR associated DP-antigens with the primed lymphocyte typing (PLT) technique. All patients and some...... of the controls were also HLA-DR typed with a limited battery of anti-DR sera. Selected PLT-cells, specific for the HLA-D/DR antigens D/DRw1-8 and the local specificity D"H" were used. The results of the PLT-experiments were evaluated with the Normalized Median Response (NMR) method and the further procedure...

  14. Engineering evaluation/cost analysis for the 105-DR and 105-F Reactor facilities and ancillary facilities

    International Nuclear Information System (INIS)

    Coenenberg, E.T.

    1998-01-01

    This document presents the results of an engineering evaluation/cost analysis (EE/CA) that was conducted to evaluate alternatives to address final disposition of the 105-DR and 105-F Reactor Buildings (subsequently referred to as facilities), including the fuel storage basins (FSB) and below-grade portions of the reactors, excluding the reactor blocks. The reactor blocks will remain in a safe storage mode for up to 75 years as identified in the Record the Decision (ROD) (58 FR 48509) for the Environmental Impact Statement (EIS), Decommissioning of Eight Surplus Production Reactors at the Hanford Site, Richland, Washington (DOE 1992a). This EE/CA also addresses final disposition of four ancillary facilities: 116-D and 116-DR Exhaust Air Stacks, 117-DR Exhaust Filter Building, and 119-DR Exhaust Air Sample Building. The 105-DR and 105-F facilities are located in the 100-D and 100-F Areas of the Hanford Site. In November 1989, the 100 Area of the Hanford Site was placed on the U.S. Environmental Protection Agency's (EPA) National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). The 100 Area NPL includes the 100-D Area (which includes the 100-DR site) and the 100-F Area, which are in various stages of the remediation process. It has been determined by DOE that hazardous substances in the 105-DR, 105-F, and the four ancillary facilities may present a potential threat to human health or the environment, and that a non-time critical removal action at these facilities is warranted. To help determine the most appropriate action, DOE, in cooperation with the Washington State Department of Ecology (Ecology) and the EPA, has prepared this EE/CA. The scope of the evaluation includes the 105-DR and 105-F facilities and the four ancillary facilities. The 116-DR and 117-DR facilities are located within the boundaries of the 105-DR Large Sodium Fire Facility Treatment, Storage, and Disposal (TSD) unit, which is

  15. Mapping the social impacts of small dams: The case of Thailand's Ing River basin.

    Science.gov (United States)

    Fung, Zali; Pomun, Teerapong; Charles, Katrina J; Kirchherr, Julian

    2018-05-24

    The social impacts of large dams have been studied extensively. However, small dams' social impacts have been largely neglected by the academic community. Our paper addresses this gap. We examine the social impacts of multiple small dams in one upstream and one downstream village in Thailand's Ing River basin. Our research is based on semi-structured interviews with beneficiaries, government and NGOs. We argue that small dams' social impacts are multi-faceted and unequal. The dams were perceived to reduce fish abundance and provide flood mitigation benefits. Furthermore, the dams enabled increased access to irrigation water for upstream farmers, who re-appropriated water via the dams at the expense of those downstream. The small dams thus engendered water allocation conflicts. Many scholars, practitioners and environmentalists argue that small dams are a benign alternative to large dams. However, the results of our research mandate caution regarding this claim.

  16. Dr. Omalu Talks Childhood, Concussions, and CTE | Poster

    Science.gov (United States)

    Dr. Bennet Omalu, the famed forensic pathologist who discovered Chronic Traumatic Encephalopathy (CTE), recently spoke at NCI at Frederick about his upbringing as well as the trials he faced while working to educate the NFL about CTE.

  17. HLA-DR typing by radioimmunoassay

    International Nuclear Information System (INIS)

    Tosi, R.; Tanigaki, N.; Centis, D.; Rossi, P.L.; Alfano, G.; Ferrara, G.B.; Pressman, D.

    1980-01-01

    A radioimmunoassay procedure is described by which peripheral blood lymphocytes can be typed for HLA-DR specificities. The major advantages of this method are the following: simple and reproducible procedure, no need for B lymphocyte separation, no need for optimal viability, and no need for preabsorption of antisera with platelets. This method will find an application in the genetic and biochemical analysis of the HLA complex, and in the clinical tests of Ia antigens for diagnostic or prognostic purposes and in retrospective transplant studies

  18. An EMD-ANN based prediction methodology for DR driven smart household load demand

    NARCIS (Netherlands)

    Tascikaraoglu, A.; Paterakis, N.G.; Catalaõ, J.P.S.; Erdinç, O.; Bakirtzis, A.G.

    2015-01-01

    This study proposes a model for the prediction of smart household load demand influenced by a dynamic pricing demand response (DR) program. Price-based DR programs have a considerable impact on household demand pattern due to the expected choice of customers or their home energy management systems

  19. Teeninduse taseme hoidmine ja heade teenindajate leidmine on tööandjatele võtmeküsimus / Anu-Mall Naarits, Anneli Mere, Kristjan Laja, Inge Suder

    Index Scriptorium Estoniae

    2009-01-01

    Anu-Mall Naarits Maratist, Anneli Mere Matkasport OÜ-st, Kristjan Laja Ambient Marketingist ning Inge Suder AS-ist Eesti Post vastavad küsimustele, mis puudutavad tagasisidet teenindusele, teenindajatele pakutavaid koolitusi ja motivatsioonipakette, teeninduse taset Eestis, teenindustöötajate palgataset, hea teenindaja isikuomadusi ning raskemaid ülesandeid teenindaja töös

  20. INTAS Secretary General Dr. J. Sinnaeve visiting Athena experiment.

    CERN Multimedia

    Patrice Loiez

    2002-01-01

    Photo 1: INTAS Secretary General Dr. J. Sinnaeve, N. Koulberg, Prof. H. Bokemeyer Head of Physics at INTAS, D.O.Williams and Rolf Landua visiting ATHENA. Photo 2: Prof. H. Bokemeyer Head of Physics at INTAS, INTAS Secretary General J. Sinnaeve and Rolf Landua visiting ATHENA. Photo 3: In the control room of ATHENA, Rolf Landua, Prof. H. Bokemeyer Head of Physics at INTAS and INTAS Secretary General Dr. J. Sinnaeve. INTAS is an independent International Association formed by the European Community, European Union´s Member States and like minded countries acting to preserve and promote the valuable scientific potential of the NIS partner countries through East-West Scientific co-operation.

  1. [Preparation and application of monoclonal antibodies against DR region of Na+-K+-ATPase α1 subunit].

    Science.gov (United States)

    Yan, Xiaofei; Wu, Litao; DU, Xiaojuan; Li, Jing; Zhang, Fujun; Han, Yan; Lyu, Shemin; Li, Dongmin

    2016-12-01

    Objective To prepare monoclonal antibodies against DR region (897DVEDSYGQQWTYEQR911) of Na + -K + -ATPase α1 subunit and identify their properties. Methods BALB/c mice were immunized with DR-keyholelimpet hemocyanin (KLH). Splenocytes from the immunized mice were collected and subsequently fused with SP2/0 mouse myeloma cells. Positive hybridoma clones were obtained after cell fusion and selection. ELISA was used to detect DR antibody titer in the cell supernatants. DR region-specific monoclonal antibodies were analyzed by dot blotting, Western blotting and immunofluorescence assay. Na + -K + -ATPase activity was detected by SensoLyte R FDP Protein Phosphatase Assay Kit and the protective effect of the monoclonal antibody against high glucose-induced cell injury was assessed in H9c2 cells. Results Three hybridoma cell lines which secreted stable DR monoclonal antibody were obtained. The strongest positive cell line, named DRm217, was selected to prepare ascites. Dot blotting, Western blotting and immunofluorescence assay showed that DRm217 recognized specially DR region of Na + -K + -ATPase and bound on H9c2 cell membranes. DRm217 stimulated Na + -K + -ATPase activity and alleviated high glucose-induced H9c2 cells injury. Conclusion The monoclonal antibodies against DR region of Na + -K + -ATPase α1 subunit is prepared.

  2. N2R vs. DR Network Infrastructure Evaluation

    DEFF Research Database (Denmark)

    Pedersen, Jens Myrup; Roost, Lars Jessen; Toft, Per Nesager

    2007-01-01

    Recent development of Internet-based services has set higher requirements to network infrastructures in terms of more bandwidth, lower delays and more reliability. Theoretical research within the area of Structural Quality of Service (SQoS) has introduced a new type of infrastructure which meet...... these requirements: N2R infrastructures. This paper contributes to the ongoing research with a case study from North Jutland. An evaluation of three N2R infrastructures compared to a Double Ring (DR) infrastructure will provide valuable information of the practical applicability of N2R infrastructures. In order...... to study if N2R infrastructures perform better than the DR infrastructure, a distribution network was established based on geographical information system (GIS) data. Nodes were placed with respect to demographic and geographical factors. The established distribution network was investigated with respect...

  3. Data of evolutionary structure change: 1DR8A-2DHTB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1DR8A-2DHTB 1DR8 2DHT A B ------------------------MKVAVLPGDGIGPEV...Chain> 2DHT B 2DHT...50 VAL CA 456 VAL CA 489 SER CA 527 2DHT... B 2DHTB AIEHKRKKVTI GLY CA 352 GLU CA 281 PHE CA 327

  4. Data of evolutionary structure change: 1DR0A-2DHTB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1DR0A-2DHTB 1DR0 2DHT A B ------------------------MKVAVLPGDGIGPEV...tryChain> 2DHT B 2DHT...95 HIS CA 348 VAL CA 450 VAL CA 478 2DHT... B 2DHTB YAIEHKRKKVT GLY CA 354 GLU CA 281 PHE CA 323 2DHT

  5. Shepard Award Winners, Part 1: Dr. Stephen Thacker

    Centers for Disease Control (CDC) Podcasts

    2009-07-22

    This podcast highlights the accomplishments of Dr. Stephen Thacker, recipient of the prestigious 2009 CDC Charles C. Shepard Award.  Created: 7/22/2009 by Centers for Disease Control and Prevention (CDC).   Date Released: 7/22/2009.

  6. Shepard Award Winners, Part 2: Dr. Tracie Williams

    Centers for Disease Control (CDC) Podcasts

    2009-07-29

    This podcast highlights the accomplishments of Dr. Tracie Williams, recipient of the prestigious 2009 CDC Charles C. Shepard Award.  Created: 7/29/2009 by Centers for Disease Control and Prevention (CDC).   Date Released: 7/29/2009.

  7. Shepard Award Winners, Part 3: Dr. Larissa Roux

    Centers for Disease Control (CDC) Podcasts

    2009-09-22

    This podcast highlights the accomplishments of Dr. Larissa Roux, recipient of the prestigious 2009 CDC Charles C. Shepard Award.  Created: 9/22/2009 by Centers for Disease Control and Prevention (CDC).   Date Released: 9/22/2009.

  8. DR3 regulation of apoptosis of naive T-lymphocytes in children with acute infectious mononucleosis.

    Science.gov (United States)

    Filatova, Elena Nikolaevna; Anisenkova, Elena Viktorovna; Presnyakova, Nataliya Borisovna; Utkin, Oleg Vladimirovich

    2016-09-01

    Acute infectious mononucleosis (AIM) is a widespread viral disease that mostly affects children. Development of AIM is accompanied by a change in the ratio of immune cells. This is provided by means of different biological processes including the regulation of apoptosis of naive T-cells. One of the potential regulators of apoptosis of T-lymphocytes is a death receptor 3 (DR3). We have studied the role of DR3 in the regulation of apoptosis of naive CD4 + (nTh) and CD8 + (nCTL) T-cells in healthy children and children with AIM. In healthy children as well as in children with AIM, the activation of DR3 is accompanied by inhibition of apoptosis of nTh. In healthy children, the stimulation of DR3 resulted in the increase in apoptosis of nCTL. On the contrary, in children with AIM, the level of apoptosis of nCTL decreased after DR3 activation, which is a positive contribution to the antiviral immune response. In children with AIM, nCTL are characterized by reduced level of apoptosis as compared with healthy children. These results indicate that DR3 can be involved in the reduction of sensitivity of nCTL to apoptosis in children with AIM.

  9. Razmerje med državnim zborom in vlado v Republiki Sloveniji

    OpenAIRE

    Holobar, Andreja

    2016-01-01

    V diplomskem delu je bilo obravnavano razmerje med državnim zborom in vlado Republike Slovenije. Državni zbor v Republiki Sloveniji predstavlja nosilca zakonodajne oblasti, vlada Republike Slovenije pa je eden izmed nosilcev izvršne oblasti. Na podlagi delitve oblasti, ki je opredeljena tudi v Ustavi Republike Slovenije, naj bi bili omenjeni veji oblasti ločeni, njuno razmerje pa uravnavajo mehanizmi ravnovesij in zavor, ki so prav tako opredeljeni v Ustavi. Uporabljeni mehanizmi naj bi zagot...

  10. Konsep Pendidikan Akhlak dan Dakwah dalam Perspektif Dr. KH. Zakky Mubarak, MA

    Directory of Open Access Journals (Sweden)

    Muchtar Muchtar

    2017-09-01

    Full Text Available Research aims to understand role, and the concept of education and dakwah in perspective Dr. KH. Zakky Mubarak, MA. This research departs from looking at the phenomenon of human life is increasingly complex, entered the modern life and globalization present and the future, wich is characterized by technical and professional paced lives, is forecast to many people ignore the moral and religious in individual and social life. The concept of moral education in the perspective of Dr. KH. Zakky Mubarak, MA that establishes the character of the learners, provide good role models, develop the moral high level, and then apply the knowledge of good character and exemplary in real life so it can become an ingrained habit. The concept of dakwah in perspective Dr. KH. Zakky Mubarak, MA at least two steps that need to be understood by a preacher, first that of bringing the wisdom, it means explaining the wisdoms contained in worship and other Islamic activities without patronizing impression, meaning a preacher should put the words and appropriate sentence appropriate to the circumstances . The second is to mau'idlah hasanah , means giving advice that touch the heart so that the message can be embedded in the memories of audience. Dr. KH. Zakky Mubarak, MA is one of the Nahdlatul Ulama cleric who spend their time preaching, either through a lecture or through scientific papers, scientific papers written contains a lot of moral education that can be used as a reference.  Keywords: Concept of Education and Dakwah, Zakky Mubarak, Nahdlatul Ulama Abstrak Penelitian ini bertujuan untuk mengetahui peran, serta konsep pendidikan akhlak dan dakwah dalam perspektif Dr. KH. Zakky Mubarak, MA. Kesimpulan penelitian ini bahwa Konsep pendidikan akhlak dalam perspektif Dr. KH. Zakky Mubarak, MA yaitu menanamkan pemahaman tentang akhlak terhadap peserta didik, memberikan keteladanan yang baik, mengembangkan pada akhlak tingkat tinggi, dan kemudian mengaplikasikan

  11. GENESI-DR: Discovery, Access and on-Demand Processing in Federated Repositories

    Science.gov (United States)

    Cossu, Roberto; Pacini, Fabrizio; Parrini, Andrea; Santi, Eliana Li; Fusco, Luigi

    2010-05-01

    GENESI-DR (Ground European Network for Earth Science Interoperations - Digital Repositories) is a European Commission (EC)-funded project, kicked-off early 2008 lead by ESA; partners include Space Agencies (DLR, ASI, CNES), both space and no-space data providers such as ENEA (I), Infoterra (UK), K-SAT (N), NILU (N), JRC (EU) and industry as Elsag Datamat (I), CS (F) and TERRADUE (I). GENESI-DR intends to meet the challenge of facilitating "time to science" from different Earth Science disciplines in discovery, access and use (combining, integrating, processing, …) of historical and recent Earth-related data from space, airborne and in-situ sensors, which are archived in large distributed repositories. In fact, a common dedicated infrastructure such as the GENESI-DR one permits the Earth Science communities to derive objective information and to share knowledge in all environmental sensitive domains over a continuum of time and a variety of geographical scales so addressing urgent challenges such as Global Change. GENESI-DR federates data, information and knowledge for the management of our fragile planet in line with one of the major goals of the many international environmental programmes such as GMES, GEO/GEOSS. As of today, 12 different Digital Repositories hosting more than 60 heterogeneous dataset series are federated in GENESI-DR. Series include satellite data, in situ data, images acquired by airborne sensors, digital elevation models and model outputs. ESA has started providing access to: Category-1 data systematically available on Internet; level 3 data (e.g., GlobCover map, MERIS Global Vegetation Index); ASAR products available in ESA Virtual Archive and related to the Supersites initiatives. In all cases, existing data policies and security constraints are fully respected. GENESI-DR also gives access to Grid and Cloud computing resources allowing authorized users to run a number of different processing services on the available data. The GENESI-DR

  12. Winston Churchill (1874-1965), Dr Robson Roose, MD Brux, FRCPE (1848-1905) and Dr Joseph Rutter, MD Lond, MRCP (1834-1913): Treatment for pneumonia in March 1886.

    Science.gov (United States)

    Vale, J Allister; Scadding, John W

    2018-01-01

    This paper will review Winston Churchill's severe respiratory illness in March 1886 when he developed pneumonia of the right lung as an 11-year-old boy. Winston was treated supportively with 'nourishment, stimulants [probably alcohol] and close watching' at his school by the 'celebrated' family physician, Dr Robson Roose, with the assistance of Dr Joseph Rutter. Roose was exemplary in his commitment to his young patient and assiduous in informing Lord Randolph Churchill of his son's clinical progress by letter.

  13. Optimization on scoliosis examination on Canons DR system

    DEFF Research Database (Denmark)

    Precht, Helle

    2007-01-01

    recordings of scoliosis today are carried out on CR systems even though most radiological departments have DR systems available. Theoretically speaking the two modalities are similar regarding dose and image quality. In this project consequently, the focus will be to obtain images of equal dose and quality...... at a DR system when using different receptors during the exam. This is a completely new opportunity, as it has earlier been difficult to compare distinct scintilators connected to the receptors due to unlike processing of the image. Given that Canon have released a receptor with CsI scintilator we...... in which theory is used as a background for the test setup and later audit appraisal. Two tests are carried out on two different hospitals with each their receptor, and afterwards the results are compared. To guarantee comparable tests the results are verified through status checks and statistical t...

  14. Cambodian and their Doctors, a Medical Anthropology of Colonial and Post-Colonial Cambodia, Jan Ovesen & Ing-Britt Trankell

    Directory of Open Access Journals (Sweden)

    Didier Bertrand

    2012-09-01

    Full Text Available Cet ouvrage, écrit par Jan Ovesen et Ing-Britt Trankell (professeurs associés d’anthropologie à l’université d’Uppsala engagés dans l’étude de la société cambodgienne depuis 1995, offre une synthèse unique d’anthropologie historique et d’ethnographie contemporaine sur le système de soins de santé cambodgien de la colonisation française à nos jours. Les auteurs décrivent la tension dans le Cambodge moderne entre la tradition médicale occidentale introduite par les colonisateurs français et le...

  15. Načini podpore prevajanju v državah Evropske unije

    OpenAIRE

    Šimenc, Agata

    2017-01-01

    Države Evropske unije poznajo različne oblike podpore, ki pomagajo pri spodbujanju in financiranju prevajanja literature v tuje jezike in s tem skrbijo za promocijo države, njene kulture, zlasti pa njene literature in njenih literarnih ustvarjalcev v tujini. Ti sistemi podpore so pomembni predvsem za literature, ki nastajajo v manj razširjenih jezikih in zato težje pridejo do tujih bralcev. Naloga primerja različne podpore prevajanju nacionalnih leposlovij v tuje jezike, ki obstajajo v različ...

  16. 105-DR Large Sodium Fire Facility closure plan. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-01

    The Hanford Site, located northwest of the city of Richland, Washington, houses reactors, chemical-separation systems, and related facilities used for the production of special nuclear materials, and activities associated with nuclear energy development. The 105-DR Large Sodium Fire Facility (LSFF), which was in operation from about 1972 to 1986, was a research laboratory that occupied the former ventilation supply room on the southwest side of the 105-DR Reactor facility. The LSFF was established to provide a means of investigating fire and safety aspects associated with large sodium or other metal alkali fires in the liquid metal fast breeder reactor (LMFBR) facilities. The 105-DR Reactor facility was designed and built in the 1950`s and is located in the 100-D Area of the Hanford Site. The building housed the 105-DR defense reactor, which was shut down in 1964. The LSFF was initially used only for engineering-scale alkali metal reaction studies. In addition, the Fusion Safety Support Studies program sponsored intermediate-size safety reaction tests in the LSFF with lithium and lithium lead compounds. The facility has also been used to store and treat alkali metal waste, therefore the LSFF is subject to the regulatory requirements for the storage and treatment of dangerous waste. Closure will be conducted pursuant to the requirements of the Washington Administrative Code (WAC) 173-303-610. This closure plan presents a description of the facility, the history of waste managed, and the procedures that will be followed to close the LSFF as an Alkali Metal Treatment Facility. No future use of the LSFF is expected.

  17. GenoType HelicoDR test in the determination of antimicrobial resistance of Helicobacter pylori in Korea.

    Science.gov (United States)

    Lee, Jung Won; Kim, Nayoung; Nam, Ryoung Hee; Park, Ji Hyun; Choi, Yoon Jin; Kim, Jung Mogg; Kim, Joo Sung; Jung, Hyun Chae

    2014-09-01

    Antimicrobial resistance of Helicobacter pylori is most important factor in eradication success. GenoType HelicoDR test has been developed for rapid detection of antimicrobial resistance. The present study evaluated the clinical usefulness of GenoType HelicoDR test in Korea. To detect 23S rRNA for clarithromycin resistance and gyrA mutations for fluoroquinolone resistance, both DNA sequencing after minimal inhibitory test (MIC) and GenoType HelicoDR test were performed in H. pylori isolates from the gastric mucosa of 101 patients. The eradication results of clarithromycin and moxifloxacin-containing triple therapy were evaluated by the 23S rRNA and gyrA mutations. For 42 isolates with A2143G mutation by GenoType HelicoDR, 83.3% (35/42) of concordance rate was estimated with DNA sequencing method and 85.7% (36/42) for MIC test. For 43 isolates with N87K mutation by GenoType HelicoDR, 71.1% (31/43) of concordance rate was estimated with DNA sequencing and 88.4% (38/43) for MIC test. The sensitivity and specificity of GenoType HelicoDR test in determination of 23S rRNA mutation were 94.9% and 87.1%, and those of gyrA 98.2% and 80.0%. The sensitivity and specificity of GenoType HelicoDR test in determination of clarithromycin resistance based on MIC test were 55.0% and 80.0%, for fluoroquinolone 74.4% and 70.0%. GenoType HelicoDR test is useful to determine mutations responsible for clarithromycin or fluoroquinolone-containing eradication failure but has a limitation for the clinical applicability in determination of resistance.

  18. Research on image reconstruction of DR/SSCT security inspection system

    International Nuclear Information System (INIS)

    Li Jian; Cong Peng

    2008-01-01

    On the basis of DR (Digital Radiography)/CT security inspection system, DR/SSCT (single slice spiral CT) security inspection system was developed. This spiral CT system can improve the CT system's drawbacks. The research work includes in replacing the former data acquisition system by a new system which can acquire projection data of multi-slices and devising the SSCT reconstruction algorithms. Simulation experiments and practical experiments were devised to contrast several algorithms. Interpolation technique was operated in detectors data in order to improve the algorithms. In conclusion, the system exploits an algorithm of weighted average of 360 degree LI (Linear Interpolation) and JH-HI (Jiang Hsieh-Half scan Interpolation). (authors)

  19. Dr. House: Patología dual en el médico

    Directory of Open Access Journals (Sweden)

    Mariano A. BELLINA

    2016-09-01

    Full Text Available Dr. House es una serie dramática estadounidense cuyo personaje central es el Dr. Gregory House, médi? co que dirige una unidad de diagnóstico (con otros tres doctores en el Hospital Universitario Princeton? Plainsboro, en Nueva Jersey. Dr. House utiliza un proceso lógico especial como base para llegar al diagnóstico. La Unidad que dirige el Dr. House trata pacientes que han sido evaluados previamente por otros doctores sin haber alcanzado un diagnóstico. Los diagnósticos oscilan desde algunos muy comunes a enfermedades raras. House no respeta las reglas y procedimientos comunes en la Medicina tradicional, tiene conflictos interpersonales graves (así como falta de empatía y no muestra interés por otras prácticas clínicas que no sean las suyas. Sufre un dolor crónico intenso en la pierna derecha por el que comienza a prescribirse Vicodin® (hidrocodona, al que acaba haciéndose dependiente. Nuestra hipótesis es que House es un caso típico de patología dual, PD (coexistencia de trastorno por uso de sustancias y otra enfermedad mental, en concreto: de dependencia de opiáceos y trastorno mixto de personalidad (comparte rasgos del trastorno de la personalidad antisocial y narcisista. La PD no es infrecuente en médicos dada la demora en pedir ayuda y la fácil accesibilidad a algunas sustancias.

  20. Dr John McLennan MD (Aberdeen), FRCP (Lond) (1801-1874) and the Medical School of Bombay that failed.

    Science.gov (United States)

    Pandya, Sunil K

    2017-01-01

    In 1826, Dr John McLennan was asked by Governor Mounstuart Elphinstone of Bombay to set up the first school to teach modern medicine to Indian citizens. He was expected to create textbooks on a variety of subjects in local languages and teach medicine to poorly educated students in their native tongues. Despite his valiant efforts, the school was deemed a failure and was abolished by the Government in 1832. Sir Robert Grant, appointed Governor of Bombay in 1835, analysed records pertaining to this medical school and concluded that the school failed since Dr McLennan was not provided the assistance he needed and as his suggestions for access to a hospital to teach medicine were not heeded. Dr McLennan provided able support to Dr Charles Morehead on his appointment as Principal and Professor of Medicine at the newly created Grant Medical College in Bombay in 1845. Dr Morehead dedicated his classic 'Clinical researches on diseases in India' to Dr McLennan. Dr McLennan headed the Board of Examiners created to assess the competence of the first batch of medical students emerging from this College. The system of evaluation set up by him remains admirable. Dr McLennan retired from service as Physician-General, full of honours.

  1. Exclusive Interview with Dr. Lassina Zerbo, Executive Secretary of the CTBTO

    International Nuclear Information System (INIS)

    Hautecouverture, Benjamin

    2013-01-01

    Dr Lassina Zerbo, the new Executive Secretary of the Comprehensive Nuclear-Test-Ban Treaty Organisation (CTBTO), was invited to speak at the Foundation for Strategic Research on 19 December 2013. Before the event, Dr. Zerbo spoke to Non-Proliferation Monthly, outlining the major axes of his strategy for the CTBTO over the coming years, his thoughts on the prospects for the Treaty's entry into force and on the role that he believes this instrument should fulfil in the political inter-State dialogue and in bilateral and multilateral diplomatic negotiation processes

  2. Interview with Dr Anna Matamala

    Directory of Open Access Journals (Sweden)

    Lucinea Marcelino Villela

    2016-09-01

    In this interview, which took place in June 2016, Dr Anna Matamala described some details about her long professional experience in Audiovisual Translation, especially in dubbing from English into Catalan, and we talked about many other things like her interest in lexicography, her point of view on some contemporary topics in Audiovisual Translation Studies: the use of technology, the relation between AVT and Accessibility Studies, AVT and Filmmaking fields, the importance of keeping in touch with other countries and even continents outside Europe, and she also gave some advice to the new generation of Translation students.

  3. Interview with Dr Anna Matamala

    Directory of Open Access Journals (Sweden)

    Lucinea Marcelino Villela

    2016-12-01

    Full Text Available In this interview, which took place in June 2016, Dr Anna Matamala described some details about her long professional experience in Audiovisual Translation, especially in dubbing from English into Catalan, and we talked about many other things like her interest in lexicography, her point of view on some contemporary topics in Audiovisual Translation Studies: the use of technology, the relation between AVT and Accessibility Studies, AVT and Filmmaking fields, the importance of keeping in touch with other countries and even continents outside Europe, and she also gave some advice to the new generation of Translation students.

  4. The great neurosis of Dr. Joseph Gerard.

    Science.gov (United States)

    Lefrère, Jean-Jacques; Rouillon, Frédéric

    2013-01-01

    The Great Neurosis, of Dr. Joseph Gerard, was published in 1889 in Paris. The book, intended for the general public, shows the different varieties of neuroses through picturesque and instructive examples. Its scientific and medical value is poor, but provides us with the various meanings of the word 'neurosis' in the late nineteenth century. Copyright © 2013 S. Karger AG, Basel.

  5. Underwater Gliders by Dr. Kevin Smith [video

    OpenAIRE

    Naval Postgraduate School Physics

    2015-01-01

    NPS Physics NPS Physics Research Projects Underwater glider research is currently underway in the physics department at the naval postgraduate in Monterey Ca. Dr. Kevin Smith is a specialist in underwater acoustics and sonar systems. He and his team are currently focused on autonomous underwater gliders and developing systems capable of detecting parameters in the ocean and listening for various sources of sound.

  6. Verification of the code DYN3D/R with the help of international benchmarks

    International Nuclear Information System (INIS)

    Grundmann, U.; Rohde, U.

    1997-10-01

    Different benchmarks for reactors with quadratic fuel assemblies were calculated with the code DYN3D/R. In this report comparisons with the results of the reference solutions are carried out. The results of DYN3D/R and the reference calculation for the eigenvalue k eff and the power distribution are shown for the steady-state 3-dimensional IAEA-Benchmark. The results of NEACRP-Benchmarks on control rod ejections in a standard PWR were compared with the reference solutions published by the NEA Data Bank. For assessing the accuracy of DYN3D/R results in comparison to other codes the deviations to the reference solutions are considered. Detailed comparisons with the published reference solutions of the NEA-NSC Benchmarks on uncontrolled withdrawal of control rods are made. The influence of the axial nodalization is also investigated. All in all, a good agreement of the DYN3D/R results with the reference solutions can be seen for the considered benchmark problems. (orig.) [de

  7. Establishment of HLA-DR4 transgenic mice for the identification of CD4+ T cell epitopes of tumor-associated antigens.

    Directory of Open Access Journals (Sweden)

    Junji Yatsuda

    Full Text Available Reports have shown that activation of tumor-specific CD4(+ helper T (Th cells is crucial for effective anti-tumor immunity and identification of Th-cell epitopes is critical for peptide vaccine-based cancer immunotherapy. Although computer algorithms are available to predict peptides with high binding affinity to a specific HLA class II molecule, the ability of those peptides to induce Th-cell responses must be evaluated. We have established HLA-DR4 (HLA-DRA*01:01/HLA-DRB1*04:05 transgenic mice (Tgm, since this HLA-DR allele is most frequent (13.6% in Japanese population, to evaluate HLA-DR4-restricted Th-cell responses to tumor-associated antigen (TAA-derived peptides predicted to bind to HLA-DR4. To avoid weak binding between mouse CD4 and HLA-DR4, Tgm were designed to express chimeric HLA-DR4/I-E(d, where I-E(d α1 and β1 domains were replaced with those from HLA-DR4. Th cells isolated from Tgm immunized with adjuvant and HLA-DR4-binding cytomegalovirus-derived peptide proliferated when stimulated with peptide-pulsed HLA-DR4-transduced mouse L cells, indicating chimeric HLA-DR4/I-E(d has equivalent antigen presenting capacity to HLA-DR4. Immunization with CDCA155-78 peptide, a computer algorithm-predicted HLA-DR4-binding peptide derived from TAA CDCA1, successfully induced Th-cell responses in Tgm, while immunization of HLA-DR4-binding Wilms' tumor 1 antigen-derived peptide with identical amino acid sequence to mouse ortholog failed. This was overcome by using peptide-pulsed syngeneic bone marrow-derived dendritic cells (BM-DC followed by immunization with peptide/CFA booster. BM-DC-based immunization of KIF20A494-517 peptide from another TAA KIF20A, with an almost identical HLA-binding core amino acid sequence to mouse ortholog, successfully induced Th-cell responses in Tgm. Notably, both CDCA155-78 and KIF20A494-517 peptides induced human Th-cell responses in PBMCs from HLA-DR4-positive donors. Finally, an HLA-DR4 binding DEPDC1191

  8. Dr Abraham Pais, 82, physicist and science historian dies

    CERN Document Server

    Glanz, J

    2000-01-01

    Obituary of Dr. Pais who died of heart failure in Copenhagen. He helped build the conceptual foundations of particle physics and then became a science historian, writing a critically acclaimed biography of Einstein (1 pg).

  9. Ingénierie de la maintenance De la conception à l'exploitation d'un bien

    CERN Document Server

    Francastel, Jean-Claude

    2003-01-01

    La maintenance a évolué : d’abord confinée à l’entretien des équipements “réparer“ les pannes puis élargie à leur surveillance “prévoir” les pannes elle est intégrée aujourd’hui dès la phase de conception du produit avec notamment le concept de “maintenabilité” du produit. L’ingénierie de maintenance désigne ce processus d’accompagnement d’un bien industriel durant toutes les phases de son cycle de vie de la conception au démantèlement qui permet d’optimiser l’exploitation de ce bien et son coût global life cycle cost. Cet ouvrage décrit les différentes phases du cycle de vie en exposant les techniques qui permettent d’intégrer à chaque étape les concepts de maintenance.

  10. The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model.

    Science.gov (United States)

    Yuksel, M; Xiao, X; Tai, N; Vijay, G M; Gülden, E; Beland, K; Lapierre, P; Alvarez, F; Hu, Z; Colle, I; Ma, Y; Wen, L

    2016-11-01

    Autoimmune hepatitis (AIH) is a chronic liver disease characterized by progressive inflammation, female preponderance and seropositivity for autoantibodies such as anti-smooth muscle actin and/or anti-nuclear, anti-liver kidney microsomal type 1 (anti-LKM1) and anti-liver cytosol type 1 (anti-LC1) in more than 80% of cases. AIH is linked strongly to several major histocompatibility complex (MHC) alleles, including human leucocyte antigen (HLA)-DR3, -DR7 and -DR13. HLA-DR4 has the second strongest association with adult AIH, after HLA-DR3. We investigated the role of HLA-DR4 in the development of AIH by immunization of HLA-DR4 (DR4) transgenic non-obese diabetic (NOD) mice with DNA coding for human CYP2D6/FTCD fusion autoantigen. Immunization of DR4 mice leads to sustained mild liver injury, as assessed biochemically by elevated alanine aminotransferase, histologically by interface hepatitis, plasma cell infiltration and mild fibrosis and immunologically by the development of anti-LKM1/anti-LC1 antibodies. In addition, livers from DR4 mice had fewer regulatory T cells (T regs ), which had decreased programmed death (PD)-1 expression. Splenic T regs from these mice also showed impaired inhibitory capacity. Furthermore, DR4 expression enhanced the activation status of CD8 + T cells, macrophages and dendritic cells in naive DR4 mice compared to naive wild-type (WT) NOD mice. Our results demonstrate that HLA-DR4 is a susceptibility factor for the development of AIH. Impaired suppressive function of T regs and reduced PD-1 expression may result in spontaneous activation of key immune cell subsets, such as antigen-presenting cells and CD8 + T effectors, facilitating the induction of AIH and persistent liver damage. © 2016 British Society for Immunology.

  11. The induction of autoimmune hepatitis in the human leucocyte antigen‐DR4 non‐obese diabetic mice autoimmune hepatitis mouse model

    Science.gov (United States)

    Yuksel, M.; Xiao, X.; Tai, N.; Vijay, G. M.; Gülden, E.; Beland, K.; Lapierre, P.; Alvarez, F.; Hu, Z.; Colle, I.; Ma, Y.

    2016-01-01

    Summary Autoimmune hepatitis (AIH) is a chronic liver disease characterized by progressive inflammation, female preponderance and seropositivity for autoantibodies such as anti‐smooth muscle actin and/or anti‐nuclear, anti‐liver kidney microsomal type 1 (anti‐LKM1) and anti‐liver cytosol type 1 (anti‐LC1) in more than 80% of cases. AIH is linked strongly to several major histocompatibility complex (MHC) alleles, including human leucocyte antigen (HLA)‐DR3, ‐DR7 and ‐DR13. HLA‐DR4 has the second strongest association with adult AIH, after HLA‐DR3. We investigated the role of HLA‐DR4 in the development of AIH by immunization of HLA‐DR4 (DR4) transgenic non‐obese diabetic (NOD) mice with DNA coding for human CYP2D6/FTCD fusion autoantigen. Immunization of DR4 mice leads to sustained mild liver injury, as assessed biochemically by elevated alanine aminotransferase, histologically by interface hepatitis, plasma cell infiltration and mild fibrosis and immunologically by the development of anti‐LKM1/anti‐LC1 antibodies. In addition, livers from DR4 mice had fewer regulatory T cells (Tregs), which had decreased programmed death (PD)‐1 expression. Splenic Tregs from these mice also showed impaired inhibitory capacity. Furthermore, DR4 expression enhanced the activation status of CD8+ T cells, macrophages and dendritic cells in naive DR4 mice compared to naive wild‐type (WT) NOD mice. Our results demonstrate that HLA‐DR4 is a susceptibility factor for the development of AIH. Impaired suppressive function of Tregs and reduced PD‐1 expression may result in spontaneous activation of key immune cell subsets, such as antigen‐presenting cells and CD8+ T effectors, facilitating the induction of AIH and persistent liver damage. PMID:27414259

  12. FIRST INTERFEROMETRIC IMAGES OF THE 36 GHz METHANOL MASERS IN THE DR21 COMPLEX

    International Nuclear Information System (INIS)

    Fish, Vincent L.; Muehlbrad, Talitha C.; Pratap, Preethi; Sjouwerman, Lorant O.; Strelnitski, Vladimir; Pihlstroem, Ylva M.; Bourke, Tyler L.

    2011-01-01

    Class I methanol masers are believed to be produced in the shock-excited environment around star-forming regions. Many authors have argued that the appearance of various subsets of class I masers may be indicative of specific evolutionary stages of star formation or excitation conditions. Until recently, however, no major interferometer was capable of imaging the important 36 GHz transition. We report on Expanded Very Large Array observations of the 36 GHz methanol masers and Submillimeter Array observations of the 229 GHz methanol masers in DR21(OH), DR21N, and DR21W. The distribution of 36 GHz masers in the outflow of DR21(OH) is similar to that of the other class I methanol transitions, with numerous multitransition spatial overlaps. At the site of the main continuum source in DR21(OH), class I masers at 36 and 229 GHz are found in virtual overlap with class II 6.7 GHz masers. To the south of the outflow, the 36 GHz masers are scattered over a large region but usually do not appear coincident with 44 GHz masers. In DR21W, we detect an 'S-curve' signature in Stokes V that implies a large value of the magnetic field strength if interpreted as due to Zeeman splitting, suggesting either that class I masers may exist at higher densities than previously believed or that the direct Zeeman interpretation of S-curve Stokes V profiles in class I masers may be incorrect. We find a diverse variety of different maser phenomena in these sources, suggestive of differing physical conditions among them.

  13. Paperwork at the service of safety? Workers' reluctance against written procedures exemplified by the concept of ‘seamanship'

    DEFF Research Database (Denmark)

    Knudsen, Fabienne

    2009-01-01

    epitomized in the concept of seamanship. Their objections suits well in Dreyfus and Dreyfus' model of skill acquisition: while novices steadily follow context-independent rules, the expert's behaviour goes beyond analytical rationality, and is situational, experience-based, and intuitive. The Aristotelian...... concept of phronesis brings us further by adding a reflexive, social and ethical dimension to the expert's knowledge. Phronesis is, like expertise, contextual, experience-based knowledge; but it is also value- and action-oriented. While phronesis rests on value rationality, ‘techne' (know how'), another...... Aristotelian concept, is based on instrumental rationality and is production-oriented. Phronesis is, inter alia, choosing the proper techne for the circumstances. However, the seamen fear a development where techne predominates at the expanse of phronesis. The case raises issues on which conditions...

  14. Kes peaks tagama seaduste täitmise? / Inge Timoštšuk, Volli Kalm, Maiki Udam ; üles kirjutanud Ülo Tikk

    Index Scriptorium Estoniae

    Timoštšuk, Inge, 1970-

    2001-01-01

    Vene koolidel käib Põhikooli- ja Gümnaasiumiseaduse § 52 teise lõike "Riigi- ja munitsipaalgümnaasiumides alustatakse üleminekut eesti õppekeelele hiljemalt 2007/08. õppeaastal" täitmine üle jõu, kuna ei jätku pädevaid õpetajaid. Teemat kommenteerivad Tartu Ülikooli prorektor Volli Kalm, Tallinna Pedagoogikaülikooli õpetajakoolituse osakonna juhataja Inge Timoštšuk ja Haridusministeeriumi kõrghariduse talituse juhataja Maiki Udam

  15. Životní jubileum RNDr. Tadeáše Czudka, DrSC

    OpenAIRE

    Hrádek, M. (Mojmír)

    2012-01-01

    Dr.Tadeaš Czudek,DrSc is an eminent Czech geomorphologist who turned eighty on April 1st, 2012. In years 1956 - 1993 he worked in the Institute of Geography of the Czechoslovak Academy of Science in Brno, part of this time as head of departement of geomorphology. He was interesting in periglacial and climatic geomorphology particularly in development of planation surfaces and specially cryopediments and significance of permafrost. He published more than 240 papers and other works and ...

  16. Perancangan Sistem Informasi Manajemen pada Klinik Skala Kecil (Studi Kasus: Klinik Dr. Jonni

    Directory of Open Access Journals (Sweden)

    Ayuliana Ayuliana

    2014-12-01

    Full Text Available The purpose of this research was to develop a database application at dr. Jonni clinic which can be used for processing and recording of operational data with an attractive user interface. Through the integrated database application, data on dr. Jonni clinic would be more structured, therefore data retrieval will go faster and more accurate, data security administration will be increased, data redundancy will be eliminated and service performance clinic dr. Jonni will also be increased. The method of analysis includes the study of literature, examination of documentation, observation, and interviews. While in the design, the method includes application design using the waterfall method models, database design and data modeling application screens using State Transition Diagrams. The results achieved from this research is an application of data base management hospital. With database applications, all data and information can be integrated well, so that it would improve the quality of  services as well as facilitate storing and accessing data. The conclusions obtained from this research is the application of data base management hospital helps in generating quick and accurate information that is used to support operations and decision-making in the clinic dr. Jonni.

  17. DR Experiments in the 60 years since the Bates paper

    International Nuclear Information System (INIS)

    Johnsen, Rainer

    2011-01-01

    About 60 years have passed since David Bates in a 1950 Physical Review Letter to the Editor first clarified the dissociative recombination mechanism (DR) of molecular ions and provided the conceptual basis for the process that plays an important role in the ionospheres of Earth and other planets, the interstellar medium, and electrical discharges. His visionary (and characteristically 'terse') thumbnail sketch of the DR mechanism only hinted at the subtleties that have kept atomic theorists and experimentalists busy for many years. In my talk, I will focus on experiments on N 2 + recombination, beginning with plasma afterglows, and then move on to the 'after'-afterglow period that is now dominated by the powerful storage-ring methods.

  18. Principles of plastic surgery portrayed by the professional life of Dr John Peter Mettauer.

    Science.gov (United States)

    Avashia, Yash J; Thaller, Seth R

    2011-11-01

    Regarded as "America's first plastic surgeon," Dr John Peter Mettauer's professional life displays 3 fundamental keystones of plastic surgery: education, innovation, and practice. To fully appreciate the history of our plastic surgery, one must look beyond a purely factual recount of noteworthy actions performed decades ago. Fundamental principles that governed achievements of our predecessors remain applicable even today. Dr Mettauer thrived as a medical student under the influence of distinguished professors in medicine at the University of Pennsylvania. Later, he continued to propagate their basic tenets when he established his medical institute in 1837. Throughout his life, Dr Mettauer combined ingenuity with scientific inquiry to devise numerous unprecedented surgical techniques and instruments. He was a prolific writer and exquisitely documented his work in medical journals for the benefit of both contemporary and future surgeons. One of Dr Mettauer's momentous achievements in plastic surgery that displays his remarkable capabilities was his contributions to management of both simple and complicated cases of cleft palate. He was the first to describe relaxing lateral incisions for treating complete cleft palates and, incidentally, was the first to successfully treat this in America. He invariably replicated similar success in establishing techniques for treating a wide range of anatomic deformities. Cumulatively, Dr Mettauer's lifelong commitment and diligence have truly laid a foundation for the eventual progress and success in the field of plastic surgery.

  19. Lasing characteristics of 1.5 μm GaInAsP-InP SCH-BIG-DR lasers

    International Nuclear Information System (INIS)

    Shim, J.I.; Komori, K.; Arai, S.; Arima, I.; Suematsu, Y.; Somchai, R.

    1991-01-01

    This paper reports that higher differential quantum efficiency η df , smaller chirp Δλ, narrower linewidth Δν, and high coupling efficiency C out between active and passive regions of 1.5 μm GaInAsP/In PSCH-BIG-Dr lasers with a thin active layer and asymmetric gratings are experimentally demonstrated by a comparison of those properties of DFB lasers from the same wafer. A submode suppression ratio (SMSR) of more than 39 dB at 1.7 times the threshold current and a C out of almost 100% in the SCH-BIG-DR lasers indicated that a separate-confinement-heterostructure (SCH) with a thin active layer and a bundle-integrated-guide (BIG) structure are quite adequate to realize high-performance distributed reflector (DR-type lasers) a two times larger η df and 16 times larger front-to-rear output ratio (FROR) of SCH-BIG-DR lasers that those of DFB lasers showed the superiority of DR lasers for high-efficiency operation. Furthermore, superior spectral characteristics of the SCH-BIG-DR laser in comparison to those of conventional DFB lasers, i.e., only about a half of chirping under a rapid direction modulation, as well as 1/5 of the linewidth-power product, were also obtained, which originated from the smaller effective linewidth enhancement factor α eff of the DR laser

  20. Dr Skateboard's Action Science: Teaching Physics in Context

    Science.gov (United States)

    Robertson, William H.

    2009-01-01

    In order to create student interest and promote new connections to the understanding of fundamental physics concepts, there is a need for new approaches and methods that are both contemporary and relevant. Dr Skateboard's Action Science, a curriculum supplement comprising video instruction and classroom activities, is an example that focuses on…

  1. Dr.LiTHO: a development and research lithography simulator

    Science.gov (United States)

    Fühner, Tim; Schnattinger, Thomas; Ardelean, Gheorghe; Erdmann, Andreas

    2007-03-01

    This paper introduces Dr.LiTHO, a research and development oriented lithography simulation environment developed at Fraunhofer IISB to flexibly integrate our simulation models into one coherent platform. We propose a light-weight approach to a lithography simulation environment: The use of a scripting (batch) language as an integration platform. Out of the great variety of different scripting languages, Python proved superior in many ways: It exhibits a good-natured learning-curve, it is efficient, available on virtually any platform, and provides sophisticated integration mechanisms for existing programs. In this paper, we will describe the steps, required to provide Python bindings for existing programs and to finally generate an integrated simulation environment. In addition, we will give a short introduction into selected software design demands associated with the development of such a framework. We will especially focus on testing and (both technical and user-oriented) documentation issues. Dr.LiTHO Python files contain not only all simulation parameter settings but also the simulation flow, providing maximum flexibility. In addition to relatively simple batch jobs, repetitive tasks can be pooled in libraries. And as Python is a full-blown programming language, users can add virtually any functionality, which is especially useful in the scope of simulation studies or optimization tasks, that often require masses of evaluations. Furthermore, we will give a short overview of the numerous existing Python packages. Several examples demonstrate the feasibility and productiveness of integrating Python packages into custom Dr.LiTHO scripts.

  2. Grading diabetic retinopathy (DR using the Scottish grading protocol

    Directory of Open Access Journals (Sweden)

    Sonia Zachariah

    2016-04-01

    Full Text Available Although traditionally the features of DR have been identified through direct ophthalmoscopy or slit lamp biomicroscopy, digital photography is more sensitive than direct ophthalmoscopy and is comparable to slit lamp examination by a trained observer.

  3. [Psychoanalysis in Buchenwald. Conversations between Bruno Bettelheim, Dr. Brief and Ernst Federn].

    Science.gov (United States)

    Federn, E

    1988-01-01

    Ernst Federn met in the concentration camp Buchenwald Bruno Bettelheim and the Chechoslovakian psychoanalyst Dr. Brief. They discussed the application of psychoanalytic knowledge to the situation in the camp, particularly the defense mechanism of "identification with the aggressor". Of the three, Bettelheim was released after one year, Dr. Brief died in Ausschwitz and Ernst Federn was liberated by the U.S.A. Army. How he could use his psychoanalytic knowledge to survive but also to help fellow prisoners is demonstrated.

  4. The Case of Dr. Oz: Ethics, Evidence, and Does Professional Self-Regulation Work?

    Science.gov (United States)

    Tilburt, Jon C; Allyse, Megan; Hafferty, Frederic W

    2017-02-01

    Dr. Mehmet Oz is widely known not just as a successful media personality donning the title "America's Doctor ® ," but, we suggest, also as a physician visibly out of step with his profession. A recent, unsuccessful attempt to censure Dr. Oz raises the issue of whether the medical profession can effectively self-regulate at all. It also raises concern that the medical profession's self-regulation might be selectively activated, perhaps only when the subject of professional censure has achieved a level of public visibility. We argue here that the medical profession must look at itself with a healthy dose of self-doubt about whether it has sufficient knowledge of or handle on the less visible Dr. "Ozes" quietly operating under the profession's presumptive endorsement. © 2017 American Medical Association. All Rights Reserved.

  5. Dr Jacob van der Land, marine biologist extraordinary

    NARCIS (Netherlands)

    Bruggen, van A.C.

    2001-01-01

    This contribution is an attempt to sketch the life and works of Dr Jacob van der Land, curator of worms and chief marine biologist of the National Museum of Natural History, on the occasion of his official retirement. Born in 1935, Jacob van der Land read biology at Leiden University (1958-1964),

  6. Decommissioning of DR 2. Experiences learnt from the completion

    International Nuclear Information System (INIS)

    Strufe, N.

    2009-10-01

    The report describes experiences gathered from the decommissioning of DR 2. The experiences encompasses planning and management of the project, methods of accomplishment, and various materials categories. Additionally, the report describes the experience with specific tools used in the project

  7. Dr. Vernon W. Hughes, 81, authority on the subatomic

    CERN Multimedia

    Lavietes, S

    2002-01-01

    "Dr. Vernon W. Hughes, a Yale physicist whose investigation of particles called muons poked holes in standard subatomic theory and provided evidence for the existence of previously undetected matter, died at Yale-New Haven Hospital last Tuesday" (1/2 page).

  8. Transcervical Inoculation with Chlamydia trachomatis Induces Infertility in HLA-DR4 Transgenic and Wild-Type Mice.

    Science.gov (United States)

    Pal, Sukumar; Tifrea, Delia F; Zhong, Guangming; de la Maza, Luis M

    2018-01-01

    Chlamydia trachomatis is the leading cause of infection-induced infertility in women. Attempts to control this epidemic with screening programs and antibiotic therapy have failed. Currently, a vaccine to prevent C. trachomatis infections is not available. In order to develop an animal model for evaluating vaccine antigens that can be applied to humans, we used C. trachomatis serovar D (strain UW-3/Cx) to induce infertility in mice whose major histocompatibility complex class II antigen was replaced with the human leukocyte antigen DR4 (HLA-DR4). Transcervical inoculation of medroxyprogesterone-treated HLA-DR4 transgenic mice with 5 × 10 5 C. trachomatis D inclusion forming units (IFU) induced a significant reduction in fertility, with a mean number of embryos/mouse of 4.4 ± 1.3 compared to 7.8 ± 0.5 for the uninfected control mice ( P < 0.05). A similar fertility reduction was elicited in the wild-type (WT) C57BL/6 mice (4.3 ± 1.4 embryos/mouse) compared to the levels of the WT controls (9.1 ± 0.4 embryos/mouse) ( P < 0.05). Following infection, WT mice mounted more robust humoral and cellular immune responses than HLA-DR4 mice. As determined by vaginal shedding, HLA-DR4 mice were more susceptible to a transcervical C. trachomatis D infection than WT mice. To assess if HLA-DR4 transgenic and WT mice could be protected by vaccination, 10 4 IFU of C. trachomatis D was delivered intranasally, and mice were challenged transcervically 6 weeks later with 5 × 10 5 IFU of C. trachomatis D. As determined by severity and length of vaginal shedding, WT C57BL/6 and HLA-DR4 mice were significantly protected by vaccination. The advantages and limitations of the HLA-DR4 transgenic mouse model for evaluating human C. trachomatis vaccine antigens are discussed. Copyright © 2017 American Society for Microbiology.

  9. Complex Strategic Choices Applying Systemic Planning for Strategic Decision Making

    CERN Document Server

    Leleur, Steen

    2012-01-01

    Effective decision making requires a clear methodology, particularly in a complex world of globalisation. Institutions and companies in all disciplines and sectors are faced with increasingly multi-faceted areas of uncertainty which cannot always be effectively handled by traditional strategies. Complex Strategic Choices provides clear principles and methods which can guide and support strategic decision making to face the many current challenges. By considering ways in which planning practices can be renewed and exploring the possibilities for acquiring awareness and tools to add value to strategic decision making, Complex Strategic Choices presents a methodology which is further illustrated by a number of case studies and example applications. Dr. Techn. Steen Leleur has adapted previously established research based on feedback and input from various conferences, journals and students resulting in new material stemming from and focusing on practical application of a systemic approach. The outcome is a coher...

  10. BEopt-CA (Ex): A Tool for Optimal Integration of EE, DR and PV in Existing California Homes

    Energy Technology Data Exchange (ETDEWEB)

    Christensen, Craig [National Renewable Energy Lab. (NREL), Golden, CO (United States); Horowitz, Scott [National Renewable Energy Lab. (NREL), Golden, CO (United States); Maguire, Jeff [National Renewable Energy Lab. (NREL), Golden, CO (United States); Velasco, Paulo Tabrares [National Renewable Energy Lab. (NREL), Golden, CO (United States); Springer, David [Davis Energy Group, Davis, CA (United States); Coates, Peter [Davis Energy Group, Davis, CA (United States); Bell, Christy [Davis Energy Group, Davis, CA (United States); Price, Snuller [Energy & Environmental Economics, San Francisco, CA (United States); Sreedharan, Priya [Energy & Environmental Economics, San Francisco, CA (United States); Pickrell, Katie [Energy & Environmental Economics, San Francisco, CA (United States)

    2014-04-01

    This project targeted the development of a software tool, BEopt-CA (Ex) (Building Energy Optimization Tool for California Existing Homes), that aims to facilitate balanced integration of energy efficiency (EE), demand response (DR), and photovoltaics (PV) in the residential retrofit1 market. The intent is to provide utility program managers and contractors in the EE/DR/PV marketplace with a means of balancing the integration of EE, DR, and PV

  11. Evaluation of GenoType NTM-DR Assay for Identification of Mycobacterium chimaera.

    Science.gov (United States)

    Mok, Simone; Rogers, Thomas R; Fitzgibbon, Margaret

    2017-06-01

    Identification of species within the Mycobacterium avium complex (MAC) is difficult, and most current diagnostic laboratory tests cannot distinguish between species included in the complex. Differentiation of species within the MAC is important, as Mycobacterium chimaera has recently emerged as a major cause of invasive cardiovascular infections following open heart surgery. A new commercial diagnostic assay, GenoType NTM-DR ver. 1.0, is intended to differentiate between three species within the MAC, namely, Mycobacterium avium , Mycobacterium intracellulare , and Mycobacterium chimaera In this study, we investigated an archival collection of 173 MAC isolates using 16S rRNA and 16S-23S internal transcribed spacer (ITS) gene sequencing, and GenoType NTM-DR was evaluated for identifying M. chimaera and other species belonging to the MAC. Species identification of 157/173 (91%) isolates with the GenoType NTM-DR assay was in agreement with 16S rRNA and 16S-23S ITS gene sequencing results. Misidentification occurred with 16 isolates which belonged to four species included in the MAC that are rarely encountered in clinical specimens. Despite some limitations of this assay, GenoType NTM-DR had 100% specificity for identifying M. chimaera This novel assay will enable diagnostic laboratories to differentiate species belonging to the Mycobacterium avium complex and to accurately identify M. chimaera It can produce rapid results and is also more cost efficient than gene sequencing methods. Copyright © 2017 American Society for Microbiology.

  12. Obituary Dr A. W. Kloos (1880—1952)

    NARCIS (Netherlands)

    Ooststroom, van S.J.

    1952-01-01

    At the end of the previous number of “Blumea” could just be inserted the death notice of one of the honorary collaborators of the Rijksherbarium, Dr Ir A. W. Kloos, who passed away in his home at Dordrecht on June 3rd, 1952. A more detailed obituary may follow here. Abraham Willem Kloos was born at

  13. Resistensi dan Sensitivitas Bakteri terhadap Antibiotik di RSU dr. Soedarso Pontianak Tahun 2011-2013

    OpenAIRE

    Nurmala Nurmala; IGN Virgiandhy; Andriani Andriani; Delima F. Liana

    2015-01-01

    Salah satu upaya untuk mengurangi resistensi, pemberian antibiotik harus berdasarkan pola bakteri penyebab infeksi dan kepekaan bakteri terhadap antibiotik. Tujuan penelitian ini untukmengetahui pola bakteri, resistensi dan sensitivitasnya terhadap antibiotik di RSU dr. SoedarsoPontianak tahun 2011-2013. Penelitian deskriptif dengan pendekatan retrospektif dilakukan RSU dr. Soedarso, Pontianak. Sampel penelitian adalah hasil pemeriksaan kultur dan uji kepekaan spesimen pus pasien yang diperi...

  14. Pressure loss tests for DR-BEP of fullsize 17 x 17 PWR fuel assembly

    International Nuclear Information System (INIS)

    Chung, Moon Ki; Chun, Se Young; Chang, Seok Kyu; Won, Soon Youn; Cho, Young Rho; Kim, Bok Deuk; Min, Kyoung Ho

    1993-01-01

    This report describes the conditions, procedure and results in the pressure loss tests carried out for a double grid type debris resistance bottom end piece (DR-BEP) designed by KAERI. In this test, the pressure loss coefficients of the full size 17 x 17 PWR simulated fuel assembly with DR-BET and with standard-BEP were measured respectively, and the pressure loss coefficients of DR-BEP were compared with the coefficients of STD-BET. The test conditions fall within the ranges of loop pressure from 5.2 to 45 bar, loop temperature from 27 to 221 deg C and Reynolds number in fuel bundle from 2.17 x 10 4 to 3.85 x 10 5 . (Author) 5 refs., 18 figs., 5 tabs

  15. Grantee Spotlight: Dr. Kolawole Okuyemi - Improving Cervical Cancer Screening Attitudes

    Science.gov (United States)

    Dr. Kolawole Okuyumi is studying cervical cancer screening attitudes and behaviors of African immigrants and refugees (Ethiopians, Nigerians, and Somalis) in Minnesota, and introducing “cancer” and “cervix” to their everyday vocabulary.

  16. Correlation of MMP-9, GA, HbA1c, and adipokines levels with DR

    Directory of Open Access Journals (Sweden)

    Cheng Qian

    2017-12-01

    Full Text Available AIM: To investigate the correlation of matrix metalloproteinase -9(MMP-9, glycated albumin(GA, glycosylated hemoglobin(HbA1cand adipokines(including visfatin, resistin and leptinwith diabetic retinopathy(DR. METHODS: From March 2015 to March 2017, 74 patients with DR were treated in our hospital, including 40 patients(80 eyeswith non proliferative diabetic retinopathy(NPDRand 34 patients(68 eyeswith proliferative diabetic retinopathy(PDR, and diabetes mellitus 40 patients(80 eyeswith non DR(NDRand 40 healthy volunteers(80 eyeswere selected as controls, the levels of MMP-9, GA, HbA1c, visfatin, resistin and leptin in each group were detected. RESULTS: PDR group visfatin was 4.41±0.82ng/mL, was significantly lower than the NPDR group, NDR group and control group(PPPPrs=0.523, 0.461 and 0.414, Prs=-0.433, Prs=0.401 and 0.460, PCONCLUSION: MMP-9, GA, HbA1c, and adipokines may play a role in the development and progression of DR, in which MMP-9 is associated with adipokines, both are not significantly related to the levels of GA and HbA1c.

  17. Dynamic simulation of a pumping system using the wind power and determination of the aeolian resources; Simulacion dinamica de un sistema de bombeo utilizando la potencia del viento y determinacion de recursos eolicos

    Energy Technology Data Exchange (ETDEWEB)

    Velasco Lozano, Miguel

    2002-05-15

    The present investigation project pretends toward analyze the possibility of pumping water using Aeolian energy from the Soto la Marina River to the Contadero Lagoon, through an eight kilometers channel. In order to obtain this objective it is necessary to analyze diverse configurations for Aeolian energy converters as well as to determine the Aeolian potential of the site. An isolated Aeolian energy pumping system will be analyzed, that is to say, without interconnection with the electric power network and another interconnected with this network. In addition, with the installation of meteorological monitoring stations a partial evaluation of the Aeolian resource in the zone will be made. This research project was born as a result of an invitation of the Dr. Eric Gustafson, President of Conservation Mexico A.C. and of Ing. Virgilio Garza, President of the Vigia Group, to participate in a project called Laguna Flamingo. Such project deals with the restoration of a habitat of aquatic birds in the Contadero Lagoon, property of Ing. Virgilio Garza in Soto la Marina, Tamaulipas, Mexico. [Spanish] El presente proyecto de investigacion pretende analizar la posibilidad de bombear agua utilizando energia eolica desde el rio Soto La Marina hasta la laguna Contadero, a traves de un canal de 8 km. Para lograr este objetivo es necesario analizar diversas configuraciones de convertidores de energia eolica asi como determinar el potencial eolico del sitio. Se analizara un sistema de bombeo con energia eolica operando aislado, es decir, sin interconexion con la red electrica y otro interconectado con dicha red. Ademas, con la instalacion de estaciones de monitoreo meteorologico se realizara una evaluacion parcial del recurso eolico en la zona. Este proyecto de investigacion nacio a raiz de una invitacion del Dr. Eric Gustafson, Presidente de Conservacion Mexico A.C. y del Ing. Virgilio Garza, Presidente del grupo Vigia, para participar en un proyecto llamado Laguna Flamingo. Tal

  18. The corpus-driven revolution in Polish Sign Language: the interview with Dr. Paweł Rutkowski

    Directory of Open Access Journals (Sweden)

    Iztok Kosem

    2018-02-01

    Full Text Available Dr. Paweł Rutkowski is head of the Section for Sign Linguistics at the University of Warsaw. He is a general linguist and a specialist in the field of syntax of natural languages, carrying out research on Polish Sign Language (polski język migowy — PJM. He has been awarded a number of prizes, grants and scholarships by such institutions as the Foundation for Polish Science, Polish Ministry of Science and Higher Education, National Science Centre, Poland, Polish–U.S. Fulbright Commission, Kosciuszko Foundation and DAAD. Dr. Rutkowski leads the team developing the Corpus of Polish Sign Language and the Corpus-based Dictionary of Polish Sign Language, the first dictionary of this language prepared in compliance with modern lexicographical standards. The dictionary is an open-access publication, available freely at the following address: http://www.slownikpjm.uw.edu.pl/en/. This interview took place at eLex 2017, a biennial conference on electronic lexicography, where Dr. Rutkowski was awarded the Adam Kilgarriff Prize and gave a keynote address entitled Sign language as a challenge to electronic lexicography: The Corpus-based Dictionary of Polish Sign Language and beyond. The interview was conducted by Dr. Victoria Nyst from Leiden University, Faculty of Humanities, and Dr. Iztok Kosem from the University of Ljubljana, Faculty of Arts.

  19. Does transitioning from computed radiography (CR) to direct radiography (DR) with portable imaging systems affect workflow efficiency?

    Science.gov (United States)

    Gali, Raja L.; Roth, Christopher G.; Smith, Elizabeth; Dave, Jaydev K.

    2018-03-01

    In digital radiography, computed radiography (CR) technology is based on latent image capture by storage phosphors whereas direct radiography (DR) technology is based either on indirect conversion using a scintillator or direct conversion using a photoconductor. DR-based portable imaging systems may enhance workflow efficiency. The purpose of this work was to investigate changes in workflow efficiency at a tertiary healthcare center after transitioning from CR to DR technology for imaging with portable x-ray units. An IRB exemption was obtained. Data for all inpatient-radiographs acquired with portable x-ray units from July-2014 till June-2015 (period 1) with CR technology (AMX4 or AMX4+ portable unit from GE Healthcare, NX workstation from Agfa Healthcare for digitization), from July-2015 till June-2016 (period 2) with DR technology (Carestream DRX-Revolution x-ray units and DRX-1C image receptors) and from July-2016 till January-2017 (period 3; same DR technology) were extracted using Centricity RIS-IC (GE Healthcare). Duration between the imaging-examination scheduled time and completed time (timesch-com) was calculated and compared using non-parametric tests (between the three time periods with corrections for multiple comparisons; three time periods were used to identify if there were any other potential temporal trends not related to transitioning from CR to DR). IBM's SPSS package was used for statistical analysis. Overall data was obtained from 33131, 32194, and 18015 cases in periods 1, 2 and 3, respectively. Independent-Samples Kruskal-Wallis test revealed a statistically significant difference in timesch-com across the three time periods (χ2(2, n= 83,340) = 2053, p < 0.001). The timesch-com was highest for period 1 i.e., radiographs acquired with CR technology (median: 64 minutes) and it decreased significantly for radiographs acquired with DR technology in periods 2 (median: 49 minutes; p < 0.001) and 3 (median∶ 44 minutes; p < 0.001). Overall

  20. A tribute to Dr. Robert C. Allen, an inspirational teacher, humanitarian, and friend (Nov. 18, 1950-Mar. 24, 2005).

    Science.gov (United States)

    Edlich, Richard F; Greene, Jill A; Long, William B

    2006-01-01

    Dr. Robert C. Allen was a gifted educator, as well as experienced ophthalmologist, who was a close personal friend of Dr. Edlich at the University of Virginia Health System. While serving on the faculty at the University of Virginia Health System, Dr. Allen proved to be a compassionate physician, who developed close personal relationships with the residents, faculty, and his patients. Dr. Allen was invited by Dr Edlich to be a member of the Editorial Board of the Journal of Long-Term Effects of Medical Implants. When Dr. Allen told Dr. Edlich that he had ocular melanoma in 2000, this news was a wake-up call to Dr. Edlich on the need to prevent skin cancer, as well as ocular melanoma. Empowered by this news, Dr. Edlich was honored to co-author four articles on skin cancer prevention, as well as the latest article focusing on prevention of ocular melanoma. The Ocular Melanoma Foundation (Richmond, VA (USA)) was founded in 2003 by Dr. Robert C. Allen to increase awareness, enhance education, and provide advocacy among both patients and health care professionals regarding this rare, but potentially lethal cancer. It has a website that provides patient information, up-to-date information and enables communication/ discourse between and among patients and practitioners (admin@ocularmelanoma.org). Dr. Allen died on March 24, 2005, at his home surrounded by family and loved ones. When surgeons are faced with challenging healthcare diseases, Dr. Edlich's mentor, Dr. Owen Wangensteen, advised Dr. Edlich that he should seek the advice and guidance of skilled basic scientists, who are familiar with the problem. Dr. Wangensteen is recognized as the greatest surgical teacher during the 20th century. Consequently, Dr. Edlich enlisted the advice and guidance from the two co-authors of the next article regarding the scientific basis for the selection of sunglasses to prevent the development of cataracts, pterygia, skin cancer, as well as ocular melanoma. Dr. Reichow is a Professor

  1. Acceptance of Medical Resume Completion at Dr. Radjiman Wediodiningrat Lawang Psychiatric Hospital

    Directory of Open Access Journals (Sweden)

    Silvia Shinta Devi

    2017-02-01

    Sistem kesehatan di Indonesia mengalami perubahan besar dengan diberlakukannya program Asuransi Kesehatan Nasional. Resume medis memiliki peran penting dalam klaim asuransi kesehatan, sehingga resume medis yang terlambat dan tidak lengkap akan mengganggu proses klaim asuransi. Penelitian ini bertujuan untuk mengetahui pengaruh persepsi kemudahan penggunaan, persepsi manfaat, dan sikap pada penerimaan dokter dalam menyelesaikan resume medis. di Dr Radjiman Wedyodiningrat Psychiatric Hospital Lawang berdasarkan Technology Acceptance Model. Technology Acceptance Model digunakan sebagai model dalam penelitian ini karena resume medis merupakan salah satu bentuk teknologi informasi yang masih dilakukan secara manual. Pengumpulan data untuk penelitian ini dilakukan pada bulan Maret 2016 dengan menggunakan kuesioner yang diberikan kepada 32 dokter di Rumah Sakit Jiwa Dr Radjiman Wediodiningrat Lawang. Skala Likert lima tingkat digunakan untuk mengukur setiap item variabel. Data dianalisis dengan menggunakan Partial Least Square. Hasil penelitian menunjukan bahwa secara umum, acceptance dokter di RSJ Dr. Radjiman Wediodiningrat Lawang terhadap pengisian resume medis masuk dalam kategori ringgi dan memiliki perceived usefulness and attitude yang dalam kategori baik, sedangkan perceived ease of use dalam kategori sedang.

  2. Faktor-Faktor Yang Mempengaruhi Kejadian Insomnia di Poliklinik Saraf RS DR. M. Djamil Padang

    OpenAIRE

    Lydia Susanti

    2015-01-01

    Abstrak Faktor risiko seperti usia lanjut, jenis kelamin wanita, penyakit penyerta (depresi dan penyakit lain), status sosial ekonomi rendah menyebabkan insomnia. Penelitian mengenai prevalensi dan faktor-faktor yang mempengaruhi kejadian insomnia di Poliklinik Saraf RS DR. M. Djamil Padang belum pernah dilakukan. Tujuan penelitian ini adalah menentukan faktor-faktor yang mempengaruhi terjadinya insomnia di poliklinik saraf RS DR. M. Djamil Padang. Penelitian ini merupakan penelitian cross se...

  3. A portrait of prefrontal lobotomy performed at the Royal Prince Alfred Hospital in Sydney by Dr Rex Money.

    Science.gov (United States)

    White, Richard T; McGee-Collett, Martin

    2016-10-01

    The objective of this article is to provide a portrait of prefrontal lobotomy performed at the Royal Prince Alfred Hospital, Sydney by the Head of Neurosurgery Dr Rex Money and to describe Dr Money's role in the promotion of psychosurgery in Sydney. We draw attention to an oral presentation by Dr Rex Money in 1951, a journal article written by Money, archival information held at the Royal Prince Alfred Hospital, including Dr Money's accounts of his travels and his reports regarding neurosurgery - both internationally and in Australia. Dr Rex Money performed a series of 13 prefrontal lobotomies between 1945 and 1951, and presented the theoretical basis for his series, his operative procedures and the outcomes at the annual meeting of its medical officers' association. Notwithstanding various deficiencies in his clinical research, Money's descriptions give a relatively comprehensive account of one of the first series of prefrontal lobotomies performed in Australia. The current article also describes Dr Money's contributions to the promotion of psychosurgery in Sydney, and illustrates the participation of a senior neurosurgeon and of a major Sydney teaching hospital during the psychosurgery saga. © The Royal Australian and New Zealand College of Psychiatrists 2016.

  4. Show: Dr. H, the life and death of pancakes

    CERN Multimedia

    2012-01-01

    Dr. H, the life and death of pancakes, a comic theatrical creation, written and performed by Heiko Buchholz.   Monday 2 April 2012 in German Tuesday 3 April 2012 in English Wednesday 4 April 2012 in French 8:30 p.m. at the Globe of Science and Innovation. This production takes a comic look at scientific methods, as applied to a common object: the pancake. More specifically, Dr H. regales his audience with statistics, experiments and scientific data surrounding this egg-and-milk-based culinary delight. And although these zany sketches are nothing short of absurd, the audience is drawn in more often than you might expect… and taken on quite an unexpected journey into the behavioural disorders, personality quirks and psychoanalysis of the base pancake. This show playfully mocks scientific logic and discourse, forcing the audience to reflect on their gullibility in the face of science and its impenetrable jargon. It purports to be neither explanation nor illustration of scientific fact,...

  5. Dr. Harry Whelan With the Light Emitting Diode Probe

    Science.gov (United States)

    1999-01-01

    The red light from the Light Emitting Diode (LED) probe shines through the fingers of Dr. Harry Whelan, a pediatric neurologist at the Children's Hospital of Wisconsin in Milwaukee. Dr. Whelan uses the long waves of light from the LED surgical probe to activate special drugs that kill brain tumors. Laser light previously has been used for this type of surgery, but the LED light illuminates through all nearby tissues, reaching parts of tumors that shorter wavelengths of laser light carnot. The new probe is safer because the longer wavelengths of light are cooler than the shorter wavelengths of laser light, making the LED less likely to injure normal brain tissue near the tumor. Also, it can be used for hours at a time while still remaining cool to the touch. The probe was developed for photodynamic cancer therapy under a NASA Small Business Innovative Research Program grant. The program is part of NASA's Technology Transfer Department at the Marshall Space Flight Center.

  6. [United Nations world population prize to Dr. Halfdan Mahler. Acceptance speech].

    Science.gov (United States)

    Mahler, H

    1995-06-01

    The professional achievements of Halfdan Mahler, for which he was awarded the 1995 UN World Population Prize, are summarized, and Dr. Mahler's acceptance speech is presented. Dr. Mahler worked for reproductive health and sustainable development during his six years as secretary general of the IPPF. Under his leadership, the IPPF established world standards for family planning and reproductive health. Dr. Mahler also guided creation and implementation of the long-term IPPF strategic plan, Vision 2000. During his tenure as director general of the World Health Organization from 1973 to 1988, he established the special program of education, development, and training for research in human reproduction. Dr. Mahler's acceptance speech sketched a world of the future in which women control their reproductive lives and enjoy equality with men in work and at home, where adolescents understand and control their sexuality, where all children are desired and cared for, and where hard work brings success even in the poorest population sectors. The challenges of achieving this vision are enormous. The world's population will have doubled to 10 billion, and tensions and inequities will persist. But if the vision is not fulfilled, the present population will triple to 15 billion and competition for every kind of resource will be intolerable. In order to succeed, the rights to free and informed reproductive decision making must be guaranteed for every couple. Harmful practices that violate the right to autonomous reproductive decision making, such as early marriage or female genital mutilation, must be eliminated. Governments must commit themselves to educating and providing resources to women so that they can exercise their rights. Family planning services must be extended to the poor and marginal population sectors that still are denied access, and to adolescents who are at risk of unwanted pregnancy and disease.

  7. Modeling Approach for Oxygen Exchange in the Human Lung under Hypobaric Conditions

    Science.gov (United States)

    2001-06-01

    Operational Medical Issues in Hypo-and Hyperbaric Conditions [les Questions medicales a caractere oprationel liees aux conditions hypobares ou hyperbares ] To...under Hypobaric Conditions DISTRIBUTION: Approved for public release, distribution unlimited This paper is part of the following report: TITLE...Approach for Oxygen Exchange in the Human Lung under Hypobaric Conditions Ing J.P.F. Lindhout*, Drs M. van de Graaff*, Ir Drs R.C. van de Graaff*, Dr

  8. Greater Philadelphia Bioinformatics Alliance (GPBA) 3rd Annual Retreat 2005

    Science.gov (United States)

    2005-11-01

    Biotech in recent days. The start of Biotech from the Agriculture ie rural side will be discussed and advancement will be discussed in detail towards...such advances in the food and Agricultural aspect. The significant results which not only makes the advancements of the understanding the public but...authored journal publications in human genetics, bioethics for industry and genetics education. Karl V. Steiner, Dr. Ing., Associate Director, Delaware

  9. Human radiation studies: Remembering the early years. Oral history of Dr. George Voelz, M.D., November 29, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-05-01

    Dr. George Voelz was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). This oral history covers Dr. Voelz`s research on Manhattan Engineering District plutonium workers, the acute and long term effects of radiation, his inhalation studies, and his activities at the 1961 INL reactor accident (SL-1 Reactor). After a brief biographical sketch, Dr. Voelz his remembrances on tissue studies of plutonium workers, the plutonium injection studies of 1945-1946, the controlled environmental radioiodine tests of 1963-1968, and tracer studies with human volunteers at Los Alamos. Dr. Voelz states his opinions concerning misconceptions about the Los Alamos Human Radiation Experiments.

  10. Human radiation studies: Remembering the early years. Oral history of Dr. George Voelz, M.D., November 29, 1994

    International Nuclear Information System (INIS)

    1995-05-01

    Dr. George Voelz was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). This oral history covers Dr. Voelz's research on Manhattan Engineering District plutonium workers, the acute and long term effects of radiation, his inhalation studies, and his activities at the 1961 INL reactor accident (SL-1 Reactor). After a brief biographical sketch, Dr. Voelz his remembrances on tissue studies of plutonium workers, the plutonium injection studies of 1945-1946, the controlled environmental radioiodine tests of 1963-1968, and tracer studies with human volunteers at Los Alamos. Dr. Voelz states his opinions concerning misconceptions about the Los Alamos Human Radiation Experiments

  11. Uzm Dr Sebahattin Okumuş 05-09-1937 - 14-03-2003

    Directory of Open Access Journals (Sweden)

    Veli Özdemir

    2003-12-01

    Full Text Available 1993 yılının Temmuz ayında tanıştık. Otopsisi ertesi güne kalan bir cenazenin başında beklerken, Fatih Adli Tabibi olduğunu anladığım iriyarı ve göbekli bir kişi kendine has yürüyüşüyle cenaze başına geldi. Daha tanışamadan elindeki dörde katlanmış ve “A4” olduğu belli olan kağıda hızlı bir biçimde not almaya başladı. Çevresiyle bağını koparmış, dış muayeneye ve elindeki kağıda konsantre olmuştu; birşey soranları “dur şimdi zamanı değil!” biçiminde geri çeviriyordu. Bu cümlenin, kendisinin her zaman kullandığı bir deyim olduğunu tanıyanlar bilir. Sonunda muayene bitti ve tanıştık; Dr. Sebahattin Okumuş imiş. “Sebahattin” olan adının “Sabahattin” olarak telaffuz edilmesine ve yazılmasına çok kızardı. Bunu ilk tanıştığımız gün anladım. Daha soma kendisiyle sık sık görüşmemizin dışmda, 1998-1999 yıllarında Fatih Adli Tabipliğinde çok yakından tanımamı sağlayacak 1 yıl kadar birlikte çalıştık... Kendi sağlığına pek dikkat etmez ve hele KOAH'lı (Kronik Obstrüktif Akciğer Hastahğı olmasına karşın ilaçlarım düzenli almaz ve bir hekim olmasına karşın doktor korkusundan dolayı kontrole gitmekten çekinirdi. Hastalığmın alevlendiği dönemlerde, ölü muayenesi için 1 kat merdiven çıkmak zorunda kalacağı için Cerrahpaşa Tıp Fakültesi'nin morguna gitmek istemezdi. 1999 yılı itibariyle 15 yıllık KOAH'lı olması ve tam konulduğu gün 20 yıh aşkın süre boyunca günde 2-3 paket kullandığı sigarayı birden bırakması (zorunda kalması dışında sağhğma pek dikkat etmemesi bildiğim en kötü yanıydı... Evine sürekli bir şeyler taşıması, oğlunun üzerine titremesi, eşi ve oğlu ile telefondaki diyaloglarından kendisinin evine pek düşkün olduğu, iyi bir “aile babası” ve “aile reisi” olduğu anlaşılıyordu. Evi ve işi dışında zaman geçirdiği tek yer Cengiz Ağabeyin (Uz

  12. VizieR Online Data Catalog: Mira stars discovered in LAMOST DR4 (Yao+, 2017)

    Science.gov (United States)

    Yao, Y.; Liu, C.; Deng, L.; de Grijs, R.; Matsunaga, N.

    2017-10-01

    By the end of 2016 March, the wide-field Large sky Area Multi-Object fiber Spectroscopic Telescope (LAMOST) DR4 catalog had accumulated 7681185 spectra (R=1800), of which 6898298 were of stars. We compiled a photometrically confirmed sample of Mira variables from the Kiso Wide-Field Camera (KWFC) Intensive Survey of the Galactic Plane (KISOGP; Matsunaga 2017, arXiv:1705.08567), the American Association of Variable Star Observers (AAVSO) International Database Variable Star Index (VSX; Watson 2006, B/vsx, version 2017-05-02; we selected stars of variability type "M"), and the SIMBAD Astronomical Database. We first cross-matched the KISOGP and VSX Miras with the LAMOST DR4 catalog. Finally, we cross-matched the DR4 catalog with the SIMBAD database. See section 2. (1 data file).

  13. VizieR Online Data Catalog: Gaia DR2 (Gaia Collaboration, 2018)

    Science.gov (United States)

    Gaia Collaboration

    2018-04-01

    Contents of Gaia DR2: The five-parameter astrometric solution - positions on the sky (alpha,delta), parallaxes, and proper motions - for more than 1.3 billion (109) sources, with a limiting magnitude of G=21 and a bright limit of G~=3. Parallax uncertainties are in the range of up to 0.04 milliarcsecond for sources at G2MASS PSC, SDSS DR9, Pan-STARRS1, GSC2.3, PPM-XL, AllWISE, and URAT-1 data on the other hand. Catalogue of radial velocity standard stars (Soubiran et al., 2018A&A..in.prep...): Individual and combined radial velocity measurements are presented for 4813 stars in rvstdcat.dat and rvstdmes.dat files. (20 data files).

  14. MSeqDR: A Centralized Knowledge Repository and Bioinformatics Web Resource to Facilitate Genomic Investigations in Mitochondrial Disease.

    Science.gov (United States)

    Shen, Lishuang; Diroma, Maria Angela; Gonzalez, Michael; Navarro-Gomez, Daniel; Leipzig, Jeremy; Lott, Marie T; van Oven, Mannis; Wallace, Douglas C; Muraresku, Colleen Clarke; Zolkipli-Cunningham, Zarazuela; Chinnery, Patrick F; Attimonelli, Marcella; Zuchner, Stephan; Falk, Marni J; Gai, Xiaowu

    2016-06-01

    MSeqDR is the Mitochondrial Disease Sequence Data Resource, a centralized and comprehensive genome and phenome bioinformatics resource built by the mitochondrial disease community to facilitate clinical diagnosis and research investigations of individual patient phenotypes, genomes, genes, and variants. A central Web portal (https://mseqdr.org) integrates community knowledge from expert-curated databases with genomic and phenotype data shared by clinicians and researchers. MSeqDR also functions as a centralized application server for Web-based tools to analyze data across both mitochondrial and nuclear DNA, including investigator-driven whole exome or genome dataset analyses through MSeqDR-Genesis. MSeqDR-GBrowse genome browser supports interactive genomic data exploration and visualization with custom tracks relevant to mtDNA variation and mitochondrial disease. MSeqDR-LSDB is a locus-specific database that currently manages 178 mitochondrial diseases, 1,363 genes associated with mitochondrial biology or disease, and 3,711 pathogenic variants in those genes. MSeqDR Disease Portal allows hierarchical tree-style disease exploration to evaluate their unique descriptions, phenotypes, and causative variants. Automated genomic data submission tools are provided that capture ClinVar compliant variant annotations. PhenoTips will be used for phenotypic data submission on deidentified patients using human phenotype ontology terminology. The development of a dynamic informed patient consent process to guide data access is underway to realize the full potential of these resources. © 2016 WILEY PERIODICALS, INC.

  15. Puma and Trail/Dr5 Pathways Control Radiation-Induced Apoptosis in Distinct Populations of Testicular Progenitors

    International Nuclear Information System (INIS)

    Coureuil, M.; Tavernier, M.; Barroca, V.; Fouchet, P.; Allemand, I.; Ugolin, N.; Chevillard, S.

    2010-01-01

    Spermatogonia- stem cells and progenitors of adult spermatogenesis- are killed through a p53-regulated apoptotic process after γ-irradiation but the death effectors are still poorly characterized. Our data demonstrate that both intrinsic and extrinsic apoptotic pathways are involved, and especially that spermatogonia can be split into two main populations, according to apoptotic effectors. Following irradiation both Dr5 and Puma genes are up-regulated in the α 6 -integrin-positive Side Population (SP) fraction, which is highly enriched in spermatogonia. Flow cytometric analysis confirms an increased number of Dr5-expressing SP cells, and Puma-β isoform accumulates in α 6 -integrin positive cellular extracts, enriched in spermatogonia. Trail -/- or Puma -/- spermatogonia display a reduced sensitivity to radiation-induced apoptosis. The TUNEL kinetics strongly suggest that the extrinsic and intrinsic pathways, via Trail/Dr5 and Puma respectively, could be engaged in distinct subpopulations of spermatogonia. Indeed flow cytometric studies show that Dr5 receptor is constitutively present on more than half of the undifferentiated progenitors (Kit - α 6 + SP) and half of the differentiated ones (Kit + α 6 + SP). In addition after irradiation, Puma is not detected in the Dr5-positive cellular fraction isolated by immuno-magnetic purification, while Puma is present in the Dr5-negative cell extracts. In conclusion, adult testicular progenitors are divided into distinct sub-populations by apoptotic effectors, independently of progenitor types (immature Kit-negative versus mature Kit-positive), underscoring differential radiosensitivities characterizing the stem cell/progenitors compartment. (authors)

  16. 105-DR Large Sodium Fire Facility Supplemental Information to the Hanford Facility Contingency Plan (DOE/RL-93-75)

    International Nuclear Information System (INIS)

    Edens, V.G.

    1998-05-01

    This document is a unit-specific contingency plan for the 105-DR Large Sodium Fire Facility and is intended to be used as a supplement to DOE/RL-93-75, Hanford Facility Contingency Plan (DOE-RL 1993). This unit-specific plan is to be used to demonstrate compliance with the contingency plan requirements of Washington Administrative Code (WAC) 173-303 for certain Resource Conservation and Recovery Act of 1976 (RCRA) waste management units.The LSFF occupied the former ventilation supply fan room and was established to provide a means of investigating fire and safety aspects associated with large sodium or other metal alkali fires. The unit was used to conduct experiments for studying the behavior of molten alkali metals and alkali metal fires. This unit had also been used for the storage and treatment of alkali metal dangerous waste. Additionally, the Fusion Safety Support Studies programs sponsored intermediate-size safety reaction tests in the LSFF with lithium and lithium-lead compounds. The LSFF, which is a RCRA site, was partially clean closed in 1995 and is documented in 'Transfer of the 105-DR Large Sodium Fire Facility to Bechtel Hanford, Inc.' (BHI 1998). In summary, the 105-DR supply fan room (1720-DR) has been demolished, and a majority of the surrounding soils were clean-closed. The 117-DR Filter Building, 116-DR Exhaust Stack, 119- DR Sampling Building, and associated ducting/tunnels were not covered under this closure

  17. Rembrandt's anatomy lesson of Dr. Deijman of 1656 dissected

    NARCIS (Netherlands)

    Ijpma, Frank F. A.; Middelkoop, Norbert E.; van Gulik, Thomas M.

    2013-01-01

    More than 350 years ago, Rembrandt painted Anatomy Lesson of Dr. Deijman. This group portrait, featuring important members of the Amsterdam Guild of Surgeons, belongs to the series of paintings of the guild. Rembrandt's masterpiece is one of the most famous historical images of a dissection of the

  18. Lack of death receptor 4 (DR4) expression through gene promoter methylation in gastric carcinoma.

    Science.gov (United States)

    Lee, Kyung Hwa; Lim, Sang Woo; Kim, Ho Gun; Kim, Dong Yi; Ryu, Seong Yeob; Joo, Jae Kyun; Kim, Jung Chul; Lee, Jae Hyuk

    2009-07-01

    To determine the underlying mechanism for the differential expression, the extent of promoter methylation in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-related genes acting downstream of TRAIL was examined in early and advanced gastric carcinomas. The extent of promoter methylation in the DR4, DR5, DcR1, DcR2, and CASP8 genes was quantified using bisulfite modification and methylation-specific polymerase chain reaction. The promoters for DcR1, DcR2, and CASP8 were largely unmethylated in early gastric carcinoma, advanced gastric carcinoma, and controls, with no significant difference among them. Protein levels of DR4, DcR1, and DcR2 as revealed by immunohistochemistry correlated with the extent of the respective promoter methylation (P < 0.05 in all cases). Hypomethylation, rather than hypermethylation, of the DR4 promoter was noted in invasive gastric malignancies, with statistical significance (P = 0.003). The promoter methylation status of TRAIL receptors in gastric carcinoma may have clinical implications for improving therapeutic strategies in patients with gastric carcinoma.

  19. Intra HLA-D/DR region recombinant detected by primed lymphocyte typing (PLT)

    DEFF Research Database (Denmark)

    Jakobsen, B K; Kristensen, T; Lamm, L U

    1983-01-01

    The chromosome 6 markers, HLA-ABC, D, DR, MT, properdin factor Bf, and complement factors 2 (C2) and 5 (C4), were studied in three families, each of which included two HLA identical siblings, one or both of whom were known to be HLA-B: GLO recombinants. The families were also typed with primed...... lymphocyte typing (PLT) for HLA-D/DR region associated DP antigens. None of these studies gave evidence that the recombinations had occurred within the HLA region. Mixed leucocyte culture (MLC) tests within the families showed no detectable stimulation between the HLA identical siblings in two...

  20. Strategies for dose reduction in ordinary radiographic examinations using CR and DR

    International Nuclear Information System (INIS)

    Willis, C.E.

    2004-01-01

    Uncoupling of display from acquisition in computed radiography (CR) and digital radiography (DR) introduces the potential for systematic overexposure without necessarily compromising image quality. Although the magnitude of radiation doses in general radiography is low compared to computed tomography and fluoroscopy, the dose to the patient is more critical in pediatric examinations than in adults, because of the greater radiosensitivity of children. This manuscript examines a variety of countermeasures for managing radiation doses in pediatric CR and DR examinations, including use of derived exposure indicators, modifications of imaging practice, and development of more efficient radiographic detectors. (orig.)

  1. Handlekompetence i naturfag

    DEFF Research Database (Denmark)

    Andersen, Thomas Bech Lillelund

    2012-01-01

    is to be seen as future potentials driven by will, but also because of the action part. I have divided knowledge in Aristotle’s three types of knowledge: episteme, techne and phronesis and argues that competences, contains all three kinds of knowledge. I argue that most assessment is on epistemic knowledge only...... to assess action competence. Inquiry suits well socio cultural theories of learning and competence goals, partly because of action and problem solving. Giving 8 grade class in science a new and authentic problem to solve I have tried to see signs of all three kinds of knowledge to estimate if action...... in Aristotle’s three types of knowledge: episteme, techne and phronesis and argues that competences, contains all three kinds of knowledge. I argue that most assessment is on epistemic knowledge only, leaving techne and phronesis out of assessment. Goals not assessed tend to disappear on behalf of easily...

  2. Autocrine secretion of tumor necrosis factor under the influence of interferon-γ amplifies HLA-DR gene induction in human monocytes

    International Nuclear Information System (INIS)

    Arenzana-Seisdedos, F.; Mogensen, S.C.; Vuillier, F.; Fiers, W.; Virelizier, J.L.

    1988-01-01

    Recombinant interferon-γ (IFN-γ) induced HLA-DR gene expression in both U937 and THP-1 human monocytic cell lines, although the former was only very weakly inducible. Combination of recombinant tumor necrosis factor (TNF) and IFN-γ resulted in a synergistic enhancement of DR mRNA and protein induction in both cell lines. TNF alone increased the constitutive expression of the DR gene in THP-1 cells. In the HLA class II-negative U937 cells, TNF used alone was not able to induce DR gene expression. Such a negative result was not due to a lack of TNF receptor expression in U937 cells, since TNF clearly induced HLA class I and TNF gene expression in this cell line. THP-1, but not U937, cells secreted TNF under the influence of IFN-γ. Neutralization of TNF by a specific antibody decreased IFN-γ-induced DR antigen expression in THP-1 cultures. These observations indicate that TNF is not able to directly induce DR gene expression, but rather amplifies ongoing expression of this gene, whether constitutive or induced by IFN-γ. In the two cell lines tested, the level of DR inducibility under the influence of IFN-γ used alone depended on a different inducibility of TNF secretion by IFN-γ. Altogether, the observations indicate that TNF, whether exogenous or endogenously produced under the influence of IFN-γ, amplifies DR gene expression in monocytes, a phenomenon that may provide to such antigen-presenting cells a selective sensitivity to the DR-inducing effects of IFN-γ

  3. The influence of Dr. Hsiang-Tung Chang on neuroscience in Union of Soviet Socialist Republics.

    Science.gov (United States)

    Jiang, Chun

    2012-10-25

    As one of the founders of Chinese neuroscience, Dr. Hsiang-Tung Chang's return to China has a profound impact on neuroscience in China. As many people expected, this action also may have influenced the development of neuroscience in other Eastern countries. Therefore, Dr. Chang's move may have changed the history of neuroscience in a greater area than China.

  4. Predominant antitumor effects by fully human anti-TRAIL-receptor2 (DR5) monoclonal antibodies in human glioma cells in vitro and in vivo

    Science.gov (United States)

    Nagane, Motoo; Shimizu, Saki; Mori, Eiji; Kataoka, Shiro; Shiokawa, Yoshiaki

    2010-01-01

    Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL/Apo2 L) preferentially induces apoptosis in human tumor cells through its cognate death receptors DR4 or DR5, thereby being investigated as a potential agent for cancer therapy. Here, we applied fully human anti-human TRAIL receptor monoclonal antibodies (mAbs) to specifically target one of death receptors for TRAIL in human glioma cells, which could also reduce potential TRAIL-induced toxicity in humans. Twelve human glioma cell lines treated with several fully human anti-human TRAIL receptor mAbs were sensitive to only anti-DR5 mAbs, whereas they were totally insensitive to anti-DR4 mAb. Treatment with anti-DR5 mAbs exerted rapid cytotoxicity and lead to apoptosis induction. The cellular sensitivity was closely associated with cell-surface expression of DR5. Expression of c-FLIPL, Akt, and Cyclin D1 significantly correlated with sensitivity to anti-DR5 mAbs. Primary cultures of glioma cells were also relatively resistant to anti-DR5 mAbs, exhibiting both lower DR5 and higher c-FLIPL expression. Downregulation of c-FLIPL expression resulted in the sensitization of human glioma cells to anti-DR5 mAbs, whereas overexpression of c-FLIPL conferred resistance to anti-DR5 mAb. Treatment of tumor-burden nude mice with the direct agonist anti-DR5 mAb KMTR2 significantly suppressed growth of subcutaneous glioma xenografts leading to complete regression. Similarly, treatment of nude mice bearing intracerebral glioma xenografts with KMTR2 significantly elongated lifespan without tumor recurrence. These results suggest that DR5 is the predominant TRAIL receptor mediating apoptotic signals in human glioma cells, and sensitivity to anti-DR5 mAbs was determined at least in part by the expression level of c-FLIPL and Akt. Specific targeting of death receptor pathway through DR5 using fully human mAbs might provide a novel therapeutic strategy for intractable malignant gliomas. PMID:20511188

  5. Regulation of MntH by a dual Mn(II- and Fe(II-dependent transcriptional repressor (DR2539 in Deinococcus radiodurans.

    Directory of Open Access Journals (Sweden)

    Hongxing Sun

    Full Text Available The high intracellular Mn/Fe ratio observed within the bacteria Deinococcus radiodurans may contribute to its remarkable resistance to environmental stresses. We isolated DR2539, a novel regulator of intracellular Mn/Fe homeostasis in D. radiodurans. Electrophoretic gel mobility shift assays (EMSAs revealed that DR2539 binds specifically to the promoter of the manganese acquisition transporter (MntH gene, and that DR0865, the only Fur homologue in D. radiodurans, cannot bind to the promoter of mntH, but it can bind to the promoter of another manganese acquisition transporter, MntABC. β-galactosidase expression analysis indicated that DR2539 acts as a manganese- and iron-dependent transcriptional repressor. Further sequence alignment analysis revealed that DR2539 has evolved some special characteristics. Site-directed mutagenesis suggested that His98 plays an important role in the activities of DR2539, and further protein-DNA binding activity assays showed that the activity of H98Y mutants decreased dramatically relative to wild type DR2539. Our study suggests that D. radiodurans has evolved a very efficient manganese regulation mechanism that involves its high intracellular Mn/Fe ratio and permits resistance to extreme conditions.

  6. The plays of Lillian Hellman, Clifford Odets and William Inge on Slovene stages

    Directory of Open Access Journals (Sweden)

    Mateja Slunjski

    2002-12-01

    Full Text Available After the Second World War, Slovene theatres started to include in their repertoires more and more American authors and their plays. Their choice were varied, from serious dramas by Eugene O'Neill, Tennessee Williams and Arthur Miller, to comedies by Norman Krasna and John Van Druten dependant mostly on the availability of the texts. In the immediate postwar years the theatres liked to present playwrights with progressive ideas in their plays, such as Lillian Hellman and her "The Little Foxes", which was successfully produced at three Slovene theatres, while her "The Children's Hour" received negative reviews. In the fifties, three theatres chose two plays by Clifford Odets, "Golden Boy" and "Country Girl", mainly because of his socially critical ideas and his admiration of humanity. His plays were rather well received; however, the critics doubted his literary genius. William Inge and his plays, "Come Back, Little Sheba", "Picnic" and "Bus Stop", chosen mainly because of the warmth with which the author depicted the tragedy and the beauty of life, were produced at three Slovene theatres. The author received rather wide-ranging opinions from the critics. Some thought him to be an unoriginal depicter of dull American life, while others praised his lyricism and new dramatic techniques.

  7. Mannose-binding lectin variant alleles and HLA-DR4 alleles are associated with giant cell arteritis

    DEFF Research Database (Denmark)

    Jacobsen, Soren; Baslund, Bo; Madsen, Hans O.

    2002-01-01

    /GCA, MBL variant alleles were associated with signs of increased inflammatory activity and clinical signs of arteritic manifestations. This was not found for HLA-DR4 alleles. These findings indicate that HLA-DR4 and MBL are contributing to the pathophysiology of GCA at different levels in the disease...... alleles in controls, patients with PMR only, and patients with GCA was 37, 32, and 53% (p = 0.01), respectively. HLA-DRB1*04 was found in 47% of patients with PMR only and in 54% of patients with GCA, which differed significantly from the 35% found in controls (p = 0.01). HLA-DR4 alleles were...... not associated with any clinical phenotypes of PMR/GCA, whereas MBL variant alleles were associated with cranial arteritis, high erythrocyte sedimentation rate, and low B-hemoglobin. CONCLUSION: We found MBL variant alleles and HLA-DR4 alleles to be weak susceptibility markers for GCA. In patients with PMR...

  8. GENESI-DR Portal: a scientific gateway to distributed repositories

    Science.gov (United States)

    Goncalves, Pedro; Brito, Fabrice; D'Andria, Fabio; Cossu, Roberto; Fusco, Luigi

    2010-05-01

    GENESI-DR (Ground European Network for Earth Science Interoperations - Digital Repositories) is a European Commission (EC)-funded project, kicked-off early 2008 lead by ESA; partners include Space Agencies (DLR, ASI, CNES), both space and no-space data providers such as ENEA (I), Infoterra (UK), K-SAT (N), NILU (N), JRC (EU) and industry as Elsag Datamat (I), CS (F) and TERRADUE (I). GENESI-DR intends to meet the challenge of facilitating "time to science" from different Earth Science disciplines in discovery, access and use (combining, integrating, processing, …) of historical and recent Earth-related data from space, airborne and in-situ sensors, which are archived in large distributed repositories. "Discovering" which data are available on a "geospatial web" is one of the main challenges ES scientists have to face today. Some well- known data sets are referred to in many places, available from many sources. For core information with a common purpose many copies are distributed, e.g., VMap0, Landsat, and SRTM. Other data sets in low or local demand may only be found in a few places and niche communities. Relevant services, results of analysis, applications and tools are accessible in a very scattered and uncoordinated way, often through individual initiatives from Earth Observation mission operators, scientific institutes dealing with ground measurements, service companies or data catalogues. In the discourse of Spatial Data Infrastructures, there are "catalogue services" - directories containing information on where spatial data and services can be found. For metadata "records" describing spatial data and services, there are "registries". The Geospatial industry coins specifications for search interfaces, where it might do better to reach out to other information retrieval and Internet communities. These considerations are the basis for the GENESI-DR scientific portal, which adopts a simple model allowing the geo-spatial classification and discovery of

  9. Multifunctional PMMA@Fe3O4@DR Magnetic Materials for Efficient Adsorption of Dyes

    Directory of Open Access Journals (Sweden)

    Bing Yu

    2017-10-01

    Full Text Available Magnetic porous microspheres are widely used in modern wastewater treatment technology due to their simple and quick dye adsorption and separation functions. In this article, we prepared porous polymethylmethacrylate (PMMA microspheres by the seed-swelling method, followed by in situ formation of iron oxide (Fe3O4 nanoparticles within the pore. Then, we used diazo-resin (DR to encapsulate the porous magnetic microspheres and achieve PMMA@Fe3O4@DR magnetic material. We studied the different properties of magnetic microspheres by different dye adsorption experiments before and after the encapsulation and demonstrated that the PMMA@Fe3O4@DR microspheres can be successfully used as a reusable absorbent for fast and easy removal of anionic and aromatic dyes from wastewater and can maintain excellent magnetic and adsorption properties in harsh environments.

  10. Dr. von Braun With a Model of a Launch Vehicle

    Science.gov (United States)

    1950-01-01

    Dr. von Braun stands beside a model of the upper stage (Earth-returnable stage) of the three-stage launch vehicle built for the series of the motion picture productions of space flight produced by Walt Disney in the mid-1950's.

  11. Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy.

    Science.gov (United States)

    Wang, Junjian; Wang, Haibin; Wang, Ling-Yu; Cai, Demin; Duan, Zhijian; Zhang, Yanhong; Chen, Peng; Zou, June X; Xu, Jianzhen; Chen, Xinbin; Kung, Hsing-Jien; Chen, Hong-Wu

    2016-11-01

    Recombinant TRAIL and agonistic antibodies to death receptors (DRs) have been in clinical trial but displayed limited anti-cancer efficacy. Lack of functional DR expression in tumors is a major limiting factor. We report here that chromatin regulator KDM4A/JMJD2A, not KDM4B, has a pivotal role in silencing tumor cell expression of both TRAIL and its receptor DR5. In TRAIL-sensitive and -resistant cancer cells of lung, breast and prostate, KDM4A small-molecule inhibitor compound-4 (C-4) or gene silencing strongly induces TRAIL and DR5 expression, and causes TRAIL-dependent apoptotic cell death. KDM4A inhibition also strongly sensitizes cells to TRAIL. C-4 alone potently inhibits tumor growth with marked induction of TRAIL and DR5 expression in the treated tumors and effectively sensitizes them to the newly developed TRAIL-inducer ONC201. Mechanistically, C-4 does not appear to act through the Akt-ERK-FOXO3a pathway. Instead, it switches histone modifying enzyme complexes at promoters of TRAIL and DR5 transcriptional activator CHOP gene by dissociating KDM4A and nuclear receptor corepressor (NCoR)-HDAC complex and inducing the recruitment of histone acetylase CBP. Thus, our results reveal KDM4A as a key epigenetic silencer of TRAIL and DR5 in tumors and establish inhibitors of KDM4A as a novel strategy for effectively sensitizing tumors to TRAIL pathway-based therapeutics.

  12. Post-Disaster Image Processing for Damage Analysis Using GENESI-DR, WPS and Grid Computing

    OpenAIRE

    Bielski, Conrad; Gentilini, Simone; Pappalardo, Marco

    2011-01-01

    The goal of the two year Ground European Network for Earth Science Interoperations-Digital Repositories (GENESI-DR) project was to build an open and seamless access service to Earth science digital repositories for European and world-wide science users. In order to showcase GENESI-DR, one of the developed technology demonstrators focused on fast search, discovery, and access to remotely sensed imagery in the context of post-disaster building damage assessment. This paper descri...

  13. Direct ex vivo detection of HLA-DR3-restricted cytomegalovirus- and Mycobacterium tuberculosis-specific CD4+ T cells.

    Science.gov (United States)

    Bronke, Corine; Palmer, Nanette M; Westerlaken, Geertje H A; Toebes, Mireille; van Schijndel, Gijs M W; Purwaha, Veenu; van Meijgaarden, Krista E; Schumacher, Ton N M; van Baarle, Debbie; Tesselaar, Kiki; Geluk, Annemieke

    2005-09-01

    In order to detect epitope-specific CD4+ T cells in mycobacterial or viral infections in the context of human class II major histocompatibility complex protein human leukocyte antigen (HLA)-DR3, two HLA-DR3 tetrameric molecules were successfully produced. One contained an immunodominant HLA-DR3-restricted T-cell epitope derived from the 65-kDa heat-shock protein of Mycobacterium tuberculosis, peptide 1-13. For the other tetramer, we used an HLA-DR3-restricted T-cell epitope derived from cytomegalovirus (CMV) pp65 lower matrix protein, peptide 510-522, which induced high levels of interferon (IFN)-gamma-producing CD4+ T cells in three of four HLA-DR3-positive CMV-seropositive individuals up to 0.84% of CD4+ T cells by intracellular cytokine staining. In peripheral blood mononuclear cells from M. tuberculosis-exposed, Mycobacterium bovis bacille Calmette-Guérin (BCG)-vaccinated, or CMV-seropositive individuals, we were able to directly detect with both tetramers epitope-specific T cells up to 0.62% and 0.45% of the CD4+ T-cell population reactive to M. tuberculosis and CMV, respectively. After a 6-day culture with peptide p510-522, the frequency of CMV-specific tetramer-binding T cells was expanded up to 9.90% tetramer+ CFSElow (5,6-carboxyfluorescein diacetate succinimidyl ester) cells within the CD4+ T-cell population, further confirming the specificity of the tetrameric molecules. Thus, HLA-DR3/peptide tetrameric molecules can be used to investigate HLA-DR3-restricted antigen-specific CD4+ T cells in clinical disease or after vaccination.

  14. Highlight: Dr David Butler-Jones on fighting pandemics | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    15 avr. 2016 ... Dr David Butler-Jones, professor in the Faculty of Medicine at the University of Manitoba and former Chief Medical Health Officer of Canada, delivered a lecture on lessons learned from the 2009 flu pandemic in Canada. He also commented on India's draft National Health Policy 2015 at the India ...

  15. [Dr. Valdimir Jakovljević--his contribution to the art of surgery].

    Science.gov (United States)

    Ilić, M

    1992-01-01

    In this article we present biographical data of Dr Vladimir Jakovljević, a surgeon (1893-1960), and his contribution to the technical approach to cephalic duodenopancreatectomy: the first pancreatico-jejunostomy, and first reported in world's literature triple different anastomosis of the jejunum with part of the stomach (after a 2/3 resection of the organ), choledochus and a part of the head of the pancreas, done by Vladimir Jakovljević in 1934, and published in "Medicinski pregled" (Medical Review) in 1935. A basic surgical teaching of Dr Jakovljević school of surgery is an aspiration toward the "physiological surgery", a technical viability for performing the most difficult operation on the biliary tract, a strong surgical imagination and full information about contemporary knowledge on surgery.

  16. Les métiers innovants de la formation. Le champ de la formation professionnelle et l'ingénierie de formation à distance

    OpenAIRE

    Marty, Olivier

    2013-01-01

    National audience; This document is extracted from a conference for PhD students at La Sorbonne University (Paris) about innovative teaching professions. It describes and analyses the crafts of vocational education as well as public distance education engineering.; Ce document est le support d'une conférence sur les métiers innovants de la formation. Après les définitions d'usage, il décrit et analyse les métiers de la formation professionnelle continue et l'ingénierie de formation à distance...

  17. Study on Al-alloy or silicide LEU for DR3 in Denmark

    Energy Technology Data Exchange (ETDEWEB)

    Haack, Karsten [Riso National Laboratory, DK 4000 Roskilde (Germany)

    1985-07-01

    The 10 MW D{sub 2}0-moderated and -cooled research reactor DR3 has at present HEU fuel available for continued operation till early 19. This report presents the status of a feasibility study prepared for selection of the best suited candidate LEU fuel type for DR3 at a potential conversion in 1988. At the moment two alternatives are evaluated: UAl-alloy with modified geometry and U{sub 3}Si{sub 2} with unchanged geometry. A decision on the type selected for further investigation is expected late 1984. The investigation should comprise development, in- and out-of-pile--testing and licensing activities on the potential LEU option. (author)

  18. Dr. Eduardo Paz Presilla: trascendental ejemplo de la medicina en la historia de nuestra localidad Dr.Eduardo Paz Presilla: momentous example of the medicine in the history of our city

    Directory of Open Access Journals (Sweden)

    Juan José Rondón Cabrera

    2009-12-01

    Full Text Available La maestría pedagógica del Dr. Eduardo Paz Presilla se mantuvo centrada en la educación como infinita obra de amor, entrega y exigencia social, pero también en el elevado cientificismo de su enseñanza. A lo largo de su fructífera vida supo ser un hombre atento, solícito, respetuoso de la ética profesional como principio de su actuación, inteligente, con gran sentido del humor y orgulloso de su familia, amigos y colegas. Por su excelente preparación clínica fue el segundo coautor del libro Temas de medicina interna, dirigido por el Dr. Reinaldo Roca Goderich, en el que estuvo a cargo de las secciones de enfermedades del sistema nervioso, reumáticas y del colágeno, inmunología y alergia.The pedagogic mastery of the Dr. Eduardo Paz Presilla focused on the education as an infinite work of love, devotion and social demand, but also on the high scientism of his teaching. During his fruitful life he knew how to be an attentive, solicitous man, respectful of the professional ethics as a principle of his performance, intelligent, with a great sense of humor and proud of his family, friends and colleagues. For his excellent clinical training he was the second coauthor of the book "Topics on Internal Medicine" directed by Dr. Reinaldo Roca Goderich, in which he was in charge of the sections on collagen, rheumatic and nervous system diseases, immunology and allergy.

  19. DR-Integrator: a new analytic tool for integrating DNA copy number and gene expression data.

    Science.gov (United States)

    Salari, Keyan; Tibshirani, Robert; Pollack, Jonathan R

    2010-02-01

    DNA copy number alterations (CNA) frequently underlie gene expression changes by increasing or decreasing gene dosage. However, only a subset of genes with altered dosage exhibit concordant changes in gene expression. This subset is likely to be enriched for oncogenes and tumor suppressor genes, and can be identified by integrating these two layers of genome-scale data. We introduce DNA/RNA-Integrator (DR-Integrator), a statistical software tool to perform integrative analyses on paired DNA copy number and gene expression data. DR-Integrator identifies genes with significant correlations between DNA copy number and gene expression, and implements a supervised analysis that captures genes with significant alterations in both DNA copy number and gene expression between two sample classes. DR-Integrator is freely available for non-commercial use from the Pollack Lab at http://pollacklab.stanford.edu/ and can be downloaded as a plug-in application to Microsoft Excel and as a package for the R statistical computing environment. The R package is available under the name 'DRI' at http://cran.r-project.org/. An example analysis using DR-Integrator is included as supplemental material. Supplementary data are available at Bioinformatics online.

  20. The sensitivity and specificity of one field non-mydriatic digital fundus photography for DR screening

    Directory of Open Access Journals (Sweden)

    Bin-Bin Li

    2013-07-01

    Full Text Available AIM:To evaluate the sensitivity and specificity of one-field non-mydriatic digital fundus photography and direct ophthalmoscopy for diabetic retinopathy(DRscreening, compared with fundus fluorescein angiography( FFA .METHODS:All 93 patients of type 1 or 2 diabetic who have underwent one-field non-mydriatic digital fundus photography, and direct ophthalmoscopy with dilation of their pupils, and FFA by ophthalmologists. The sensitivity and specificity of one-field non-mydriatic digital fundus photography and direct ophthalmoscopy were calculated respectively, compared with FFA.RESULTS: The sensitivity and specificity of one-field non-mydriatic digital fundus photography for detection of any DR were 80.4% and 94.7%; The sensitivity and specificity of direct ophthalmoscopy for detection of any DR were 64.2% and 84.2%; After the standard for referable DR being lowered down to the moderate non-proliferative diabetic retinopathy(M-NPDR, the sensitivity and specificity of non-mydriatic digital fundus photography for detection were 88.9% and 98.4%, the sensitivity and specificity of direct ophthalmoscopy for detection were 71.5% and 96.7%.CONCLUSION: One-field non-mydriatic digital fundus photography is an effective method for DR screening.

  1. Expression of MIF and CD74 in leukemic cell lines: correlation to DR expression destiny.

    Science.gov (United States)

    Georgouli, Mirella; Papadimitriou, Lina; Glymenaki, Maria; Patsaki, Valia; Athanassakis, Irene

    2016-06-01

    Invariant chain (Ii) or CD74 is a non-polymorphic glycoprotein, which apart from its role as a chaperone dedicated to MHCII molecules, is known to be a high-affinity receptor for macrophage migration inhibitory factor (MIF). The present study aimed to define the roles of CD74 and MIF in the immune surveillance escape process. Towards this direction, the cell lines HL-60, Raji, K562 and primary pre-B leukemic cells were examined for expression and secretion of MIF. Flow cytometry analysis detected high levels of MIF and intracellular/membrane CD74 expression in all leukemic cells tested, while MIF secretion was shown to be inversely proportional to intracellular HLA-DR (DR) expression. In the MHCII-negative cells, IFN-γ increased MIF expression and induced its secretion in HL-60 and K562 cells, respectively. In K562 cells, CD74 (Iip33Iip35) was shown to co-precipitate with HLA-DOβ (DOβ), inhibiting thus MIF or DR binding. Induced expression of DOα in K562 (DOα-DOβ+) cells in different transfection combinations decreased MIF expression and secretion, while increasing surface DR expression. Thus, MIF could indeed be part of the antigen presentation process.

  2. Capsaicin sensitizes TRAIL-induced apoptosis through Sp1-mediated DR5 up-regulation: Involvement of Ca2+ influx

    International Nuclear Information System (INIS)

    Moon, Dong-Oh; Kang, Chang-Hee; Kang, Sang-Hyuck; Choi, Yung-Hyun; Hyun, Jin-Won; Chang, Weon-Young; Kang, Hee-Kyoung; Koh, Young-Sang; Maeng, Young-Hee; Kim, Young-Ree; Kim, Gi-Young

    2012-01-01

    Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in various malignant cells, several cancers including human hepatocellular carcinoma (HCC) exhibit potent resistance to TRAIL-induced cell death. The aim of this study is to evaluate the anti-cancer potential of capsaicin in TRAIL-induced cancer cell death. As indicated by assays that measure phosphatidylserine exposure, mitochondrial activity and activation of caspases, capsaicin potentiated TRAIL-resistant cells to lead to cell death. In addition, we found that capsaicin induces the cell surface expression of TRAIL receptor DR5, but not DR4 through the activation Sp1 on its promoter region. Furthermore, we investigated that capsaicin-induced DR5 expression and apoptosis are inhibited by calcium chelator or inhibitors for calmodulin-dependent protein kinase. Taken together, our data suggest that capsaicin sensitizes TRAIL-mediated HCC cell apoptosis by DR5 up-regulation via calcium influx-dependent Sp1 activation. Highlights: ► Capsaicin sensitizes TRAIL-induced apoptosis through activation of caspases. ► Capsaicin induces expression of DR5 through Sp1 activation. ► Capsaicin activates calcium signaling pathway.

  3. A clinician friendly data warehouse oriented toward narrative reports: Dr. Warehouse.

    Science.gov (United States)

    Garcelon, Nicolas; Neuraz, Antoine; Salomon, Rémi; Faour, Hassan; Benoit, Vincent; Delapalme, Arthur; Munnich, Arnold; Burgun, Anita; Rance, Bastien

    2018-04-01

    Clinical data warehouses are often oriented toward integration and exploration of coded data. However narrative reports are of crucial importance for translational research. This paper describes Dr. Warehouse®, an open source data warehouse oriented toward clinical narrative reports and designed to support clinicians' day-to-day use. Dr. Warehouse relies on an original database model to focus on documents in addition to facts. Besides classical querying functionalities, the system provides an advanced search engine and Graphical User Interfaces adapted to the exploration of text. Dr. Warehouse is dedicated to translational research with cohort recruitment capabilities, high throughput phenotyping and patient centric views (including similarity metrics among patients). These features leverage Natural Language Processing based on the extraction of UMLS® concepts, as well as negation and family history detection. A survey conducted after 6 months of use at the Necker Children's Hospital shows a high rate of satisfaction among the users (96.6%). During this period, 122 users performed 2837 queries, accessed 4,267 patients' records and included 36,632 patients in 131 cohorts. The source code is available at this github link https://github.com/imagine-bdd/DRWH. A demonstration based on PubMed abstracts is available at https://imagine-plateforme-bdd.fr/dwh_pubmed/. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  4. Tribute to Emil Wolf: Science and Engineering Legacy of Physical Optics

    Science.gov (United States)

    2004-09-23

    1983; his Ph.D. research examined a novel nonimag - ing solar thermal collector with Prof. Roland Winston. While at NRL, Dr. Snail has published more...advanced illumination systems, sensors, and nonimaging optical devices. This SPIE Press book pays tribute to Emil Wolf (see Fig. 1) for his pio- neering...who described the effect of nonimage forming optical systems and scattering media in terms of the Mueller formalism; Edwin H. Land,† who invented the

  5. Typing of human fetal organs for the histocompatibility antigens A, B and DR.

    Science.gov (United States)

    Tuch, B E; Doran, T J; Messel, N; Turtle, J R

    1985-01-01

    In the transplantation of human fetal pancreatic explants into diabetic man, the importance of matching the histocompatibility antigens of donor and recipient to decrease the chances of rejection is unknown. Before this question can be answered human fetuses must be tissue typed. We have shown that lymphocytes harvested from fetal liver, thymus, bone marrow and spleen can be successfully HLA DR typed in 64% and A and B typed in 57% of 58 fetuses aged 15 wk or more. Typing should ideally be carried out on unseparated T and B cells. Best results were achieved if all four of the above organs were available and more than one million viable cells were able to be harvested for typing. Whilst the DR antigens could be typed from all tissues, the A and B antigens could be typed, with few exceptions only from thymus, spleen and bone marrow. The efficacy of matching the histocompatibility antigens of recipient and donor fetuses, especially the DR antigens can now be tested in the human diabetic being transplanted with pancreatic explants.

  6. Professor Oberth and Dr. von Braun at ARS Banquet

    Science.gov (United States)

    1961-01-01

    Dr. Wernher von Braun holds the coveted Hermarn Oberth award presented to him by Professor Oberth during the banquet hosted by the Alabama Section of the American Rocket Society (ARS), on October 19, 1961. The Oberth award was given for outstanding technical contributions to the field of astronautics or for the promotion and advancement of astronautical sciences.

  7. Photoelectric UBV-photometry of the In(YY) DR Tauri-type young star in 1982-1986

    International Nuclear Information System (INIS)

    Kolotilov, E.A.

    1987-01-01

    The results of photoelectric UBV-photometry carried out in 1982-1986 for DR TAU - the star which undergone nova-like brightness increase in 1965-1980 - are presented. The brightness variations of the star during the post-maximum period include several days lasting flares and much more rare deep minima. The averaged colour-brightness relations are as follows: the higher brightness, the bluer B - V colour and the redder U - B colour. However the fast variations on a time scale of days do not always follow this relation. The observed pattern of variability of DR Tau is in agreement with the model of young stars activity (Grinin, 1980) proposing the appearance of hot spots in stellar atmosphere due to accretion of gas. Some arguments for the binarity of DR Tau are presented

  8. Science Matters Podcast: Questions and Answers with EPA's Dr. Peter Grevatt

    Science.gov (United States)

    Listen to a podcast with Dr. Peter Grevatt, the director of EPA's Office of Children's Health Protection, as he answers questions about children's health, or read some of the highlights from the conversation here.

  9. Joint conference of iMEC 2015 (2nd International Manufacturing Engineering Conference and APCOMS 2015 (3rd Asia-Pacific Conference on Manufacturing Systems)

    International Nuclear Information System (INIS)

    2016-01-01

    ;Nanomaterials with Exceptional Properties Synthesized through Top Down Approach”, which was warmly welcomed by an eager and highly motivated audience. The second keynote speaker was Prof. Ir. Dradjad Irianto (ITB, Indonesia) on “Collaborative Manufacturing for Small-medium Enterprises”. The organizers are very grateful to them for supporting the conference and sharing their latest research results with the conference participants. The conference organizers would like to express our sincere gratitude and thanks to the honorary chairman Prof. Dato, Dr. Daing Nasir Ibrahim and Prof. Dr. Wan Azhar Wan Yusoff and organizing committee members of iMEC2015, Assoc. Prof. Dr. A.K. Prasada Rao (chairman), Dr. Ing. Mohd Azmir Mohd Azhari (co-chairman), and all committee members Assoc. Prof. Dr. Ahmad Razlan Yusoff, Assoc. Prof. Dr. Ismed Iskandar, Dr Noraini Mohd Razali, Dr Muhammed Nafis Osman Zahid, Dr Noor Mazni Ismail, Dr Izwan Ismail, Dr Zamzuri Hamedon, Dr Faiz Mohd Turan, Ms Suraya Sulaiman and secretariat Miss Zuryaty, Mrs Wan Norshihah, Mr. Mohd Khairulnazri and Mr Rafilah and also a million thanks to the steering committee from APCOMS Prof. Dr. Kadarsyah Suryadi, Prof. Dr. Bermawi, P. Iskandar, Prof. Dr. Abdul Hakim Halim, Prof. Dr. Dradjad Irianto, Dr. TMA Ari Samadhi, Ir. I Made Dana Tangkas and APCOMS organizing committee Prof. Dr. Abdul Hakim Halim (chair), Dr. Rachmawati Wangsaputra (co-chair) and other committee members Dr. Iwan Inrawan Wiratmadja, Dr. Anas Ma'ruf, Dr. Sukoyo and Dr. Wisnu Aribowo. The editorial board are indebted to all of the reviewers who were willing to spend their precious time in reviewing the papers. Thanks also to all who contributed direct or indirectly in making this conference a success, especially Mr. Mohd Khairulnazri in helping the editors complete the proceedings. Dr. Zamzuri Hamedon Editor in-chief iMEC and APCOMS 2015 Associate Editors 1. Assoc. Prof. Dr. A.K. Prasada Rao 2. Assoc. Prof. Dr. Ahmad Razlan Yusoff 3. Dr. Ing. Mohd Azmir

  10. Joint conference of iMEC 2015 (2nd International Manufacturing Engineering Conference & APCOMS 2015 (3rd Asia-Pacific Conference on Manufacturing Systems)

    Science.gov (United States)

    2016-02-01

    Properties Synthesized through Top Down Approach”, which was warmly welcomed by an eager and highly motivated audience. The second keynote speaker was Prof. Ir. Dradjad Irianto (ITB, Indonesia) on “Collaborative Manufacturing for Small-medium Enterprises”. The organizers are very grateful to them for supporting the conference and sharing their latest research results with the conference participants. The conference organizers would like to express our sincere gratitude and thanks to the honorary chairman Prof. Dato, Dr. Daing Nasir Ibrahim and Prof. Dr. Wan Azhar Wan Yusoff and organizing committee members of iMEC2015, Assoc. Prof. Dr. A.K. Prasada Rao (chairman), Dr. Ing. Mohd Azmir Mohd Azhari (co-chairman), and all committee members Assoc. Prof. Dr. Ahmad Razlan Yusoff, Assoc. Prof. Dr. Ismed Iskandar, Dr Noraini Mohd Razali, Dr Muhammed Nafis Osman Zahid, Dr Noor Mazni Ismail, Dr Izwan Ismail, Dr Zamzuri Hamedon, Dr Faiz Mohd Turan, Ms Suraya Sulaiman and secretariat Miss Zuryaty, Mrs Wan Norshihah, Mr. Mohd Khairulnazri and Mr Rafilah and also a million thanks to the steering committee from APCOMS Prof. Dr. Kadarsyah Suryadi, Prof. Dr. Bermawi, P. Iskandar, Prof. Dr. Abdul Hakim Halim, Prof. Dr. Dradjad Irianto, Dr. TMA Ari Samadhi, Ir. I Made Dana Tangkas and APCOMS organizing committee Prof. Dr. Abdul Hakim Halim (chair), Dr. Rachmawati Wangsaputra (co-chair) and other committee members Dr. Iwan Inrawan Wiratmadja, Dr. Anas Ma'ruf, Dr. Sukoyo and Dr. Wisnu Aribowo. The editorial board are indebted to all of the reviewers who were willing to spend their precious time in reviewing the papers. Thanks also to all who contributed direct or indirectly in making this conference a success, especially Mr. Mohd Khairulnazri in helping the editors complete the proceedings. Dr. Zamzuri Hamedon Editor in-chief iMEC & APCOMS 2015 Associate Editors 1. Assoc. Prof. Dr. A.K. Prasada Rao 2. Assoc. Prof. Dr. Ahmad Razlan Yusoff 3. Dr. Ing. Mohd Azmir Mohd Azhari 4. Dr. Muhammed

  11. Effect of an azo dye (DR1) on the dielectric parameters of a nematic liquid crystal system

    International Nuclear Information System (INIS)

    Ozder, S.; Okutan, M.; Koeysal, O.; Goektas, H.; San, S.E.

    2007-01-01

    The dielectric parameters and relaxation properties of azo dye (DR1) doped E7 and pure E7 liquid crystal (LC) have been investigated in a wide frequency range of 10 k-10 MHz through the dielectric spectroscopy method at room temperature. Dielectric anisotropy (Δε) property of the LC changes from the positive type to negative type and dielectric anisotropy values decrease with doping of DR1. The relaxation frequency f r of E7 and E7/DR1 LC was calculated by means of Cole-Cole plots. Influence of bias voltage on the dielectric parameters has also been investigated

  12. Prof. DR. F. C. Eloff - An appreciation

    Directory of Open Access Journals (Sweden)

    G de Graaff

    1984-12-01

    Full Text Available I have been requested to write an appreciation of the man to whom these proceedings of a symposium on the Kalahari Ecosystem are dedicated @ Prof. Dr. F. C. Eloff, or Fritz as he is popularly referred to. I undertook the task with some trepidation and the only claim to the honour to write this article may be the fact that I have known Professor Eloff since 1949 when I was a green-shanked first year veterinary student at the University of Pretoria where he lectured in zoology to the new students.

  13. Zingiber officinale, Piper retrofractum and Combination Induced Apoptosis and p53 Expression in Myeloma and WiDr Cell Lines

    Directory of Open Access Journals (Sweden)

    HENY EKOWATI

    2012-09-01

    Full Text Available In previous studies, Zingiber officinale, Piper retrofractum, and the combination showed cytotoxic activity, induced apoptosis, and p53 expression of HeLa, T47D, and MCF-7 cell lines. This study was conducted to investigate the cytotoxic and apoptotic activity of Zingiber officinale (ZO, Piper retrofractum (PR, and the combination as well as their effect to p53 expression on Myeloma and WiDr cells. The powder of ZO, PR, and ZO + PR combination (1:1 were macerated with 96% ethanol for 3 x 24 hours. MTT cytotoxic assay was performed on Myeloma and WiDr cell lines. Apoptotic cells were stained with ethidium bromide and acridine orange. Imunohistochemical expression of p53 was examined on Myeloma and WiDr cell lines. Doxorubicin was used as positive control in all assays. Results showed that ZO, PR, and ZO + PR combination had cytotoxic activity on Myeloma cells with IC50 of 28, 36, and 55 mg/ml respectively and WiDr cell lines with IC50 of 74, 158, and 64 mg/ml respectively, induced apoptotic activity, and increased p53 expression on Myeloma and WiDr cells. These results suggest that ZO, PR, and their combination induced Myeloma and WiDr cells in apoptosis through p53 expression.

  14. FAKTOR RISIKO KEJADIAN PREEKLAMPSIA PADA IBU HAMIL DI RSUP DR. M. DJAMIL PADANG TAHUN 2014

    OpenAIRE

    Dien Gusta Anggraini Nursal; Pratiwi Tamela; Fitrayeni Fitrayeni

    2017-01-01

    Preeklampsia merupakan penyakit yang disebabkan kehamilan dan penyebab kematian maternal. Angka kejadian preeklampsia di RSUP. DR. M. Djamil Padang Tahun 2014 adalah 20,14%. Tujuan penelitian ini mengetahui faktor risiko yang berhubungan dengan kejadian preeklampsia pada ibu hamil di RSUP DR. M. Djamil Padang tahun 2014. Jenis penelitian observasional analitik dengan rancangan kasus kontrol. Jumlah sampel 34 kasus dan 34 kontrol, perbandingan 1:1. Pengambilan sampel menggunakan teknik systema...

  15. Faktor Risiko Kejadian Preeklampsia pada Ibu Hamil di Rsup Dr. M. Djamil Padang Tahun 2014

    OpenAIRE

    Nursal, Dien Gusta Anggraini; Tamela, Pratiwi; Fitrayeni, Fitrayeni

    2015-01-01

    Preeklampsia merupakan penyakit yang disebabkan kehamilan dan penyebab kematian maternal. Angka kejadian preeklampsia di RSUP. DR. M. Djamil Padang Tahun 2014 adalah 20,14%. Tujuan penelitian ini mengetahui faktor risiko yang berhubungan dengan kejadian preeklampsia pada ibu hamil di RSUP DR. M. Djamil Padang tahun 2014. Jenis penelitian observasional analitik dengan rancangan kasus kontrol. Jumlah sampel 34 kasus dan 34 kontrol, perbandingan 1:1. Pengambilan sampel menggunakan teknik systema...

  16. Dr Fabiola Gianotti has been selected by CERN Council to become next CERN Director General

    CERN Multimedia

    Brice, Maximilien

    2014-01-01

    With the next Director-General announced, watch the press conference starting in a few minutes via http://cern.ch/webcast/ and send your questions via Twitter to @CERNpressoffice CERN Council selects Italian physicist, Dr Fabiola Gianotti, as CERN’s next Director-General. Dr Gianotti’s mandate will begin on 1 January 2016 and run for a period of five years, read more: http://cern.ch/go/tN09F

  17. Sedimentary environments in the south-western Barents Sea during the last deglaciation and the Holocene: a case study outside the Ingøydjupet trough

    Directory of Open Access Journals (Sweden)

    Mauro Pau

    2016-05-01

    Full Text Available A lithological and foraminiferal study of newly acquired sediment cores outside the Ingøydjupet (Ingøy Deep trough has been carried out to improve constraints on the last deglacial history in the south-western Barents Sea. Three lithofacies and three foraminiferal facies were identified. The lowermost lithological unit is a diamicton interpreted as glacial till. It contains a low-abundance, ecologically mixed foraminiferal assemblage, presumably resulting from glacial reworking. Above the diamicton, a layer of ice-rafted debris (IRD, likely associated with intensive iceberg production, marks the initial destabilization of the marine-based ice sheet. At this time, ca. 15.6–15.0 Ky B.P., opportunistic foraminiferal species Nonionellina labradorica and Stainforthia spp. reached peak abundance. During the south-western Barents Sea ice-margin retreat, presumably corresponding to the Bølling interstadial, a sequence of glaciomarine laminations was deposited conformably on the layer of IRD. Sedimentation rates were apparently high (estimated about 0.4 cm per year and the foraminiferal fauna was dominated by Elphidium spp. and Cassidulina reniforme, species common for glacier-proximal environments. A hiatus at the top of the deglacial unit is likely linked to the high bottom-current activity associated with a strengthened inflow of Atlantic water masses into the Barents Sea. The uppermost lithological unit is represented by the Holocene marine sandy mud. It contains a high-abundance, high-diversity foraminiferal fauna with common cassidulinids, Cibicides spp., Epistominella pusilla and planktic species.

  18. Removal Action Work Plan for 105-DR and 105-F Building Interim Safe Storage Projects and Ancillary Buildings

    International Nuclear Information System (INIS)

    Morton, M.R.

    2000-01-01

    This document contains the removal action work plan for the 105-DR and 105-F Reactor buildings and ancillary facilities. These buildings and facilities are located in the 100-D/DR and 100-F Areas of the Hanford Site, which is owned and operated by the US Department of Energy (DOE), in Benton County, Washington. The 100 Areas (including the 100-D/DR and 100-F Areas) of the Hanford Site were placed on the US Environmental Protection Agency's (EPA's) National Priorities List under the ''Comprehensive Environmental Response, Compensation, and Liability Act of 1980'' (CERCLA). The DOE has determined that hazardous substances in the 105-DR and 105-F Reactor buildings and four ancillary facilities present a potential threat to human health or the environment. The DOE has also determined that a non-time critical removal action is warranted at these facilities. Alternatives for conducting a non-time critical removal action were evaluated in the ''Engineering Evaluation/Cost Analysis for the 105-DR and 105-F Reactor Facilities and Ancillary Facilities'' (DOE-RL 1998a). The engineering evaluation/cost analysis (EE/CA) resulted in the recommendation to decontaminate and demolish the contaminated reactor buildings (except for the reactor blocks) and the ancillary facilities and to construct a safe storage enclosure (SSE) over the reactor blocks. The recommendation was approved in an action memorandum (Ecology et al. 1998) signed by the Washington State Department of Ecology (Ecology), EPA, and DOE. The DOE is the agency responsible for implementing the removal actions in the 105-D/DR and 105-F Areas. Ecology is the lead regulatory agency for facilities in the 100-D/DR Area, and EPA is the lead regulatory agency for facilities in the 100-F Area. The term ''lead regulator agency'' hereinafter, refers to these authorities. This removal action work plan supports implementation of the non-time critical removal action

  19. Removal Action Workplan for the 105-DR and 105-F Building Interim Safe Storage Projects and Ancillary Buildings

    International Nuclear Information System (INIS)

    Rodovsky, T. J.

    1999-01-01

    This document is the removal action workplan (RAW) for the 105-DR and 105-F Reactor Buildings and ancillary facilities. These buildings and facilities are located in the 100-D/DR and 100-F Areas of the Hanford Site in Benton County, Washington, which is owned and operated by the U.S. Department of Energy (DOE). The 100 Areas (including 100-D/DR and 100-F Areas) of the Hanford Site were placed on the U.S. Environmental Protection Agency's (EPA) National Priorities List under the Comprehensive Environmental Response, Compensation,and Liability Act of 1980 (CERCLA). DOE has determined that hazardous substances in the 105-DR and 105-F Reactor Buildings and four ancillary facilities present a potential threat to human health or the environment DOE has also determined that a non-time critical removal action is warranted at these facilities

  20. Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages.

    Directory of Open Access Journals (Sweden)

    Anupama Reddy

    Full Text Available Death Receptor 5 (DR5 agonists demonstrate anti-tumor activity in preclinical models but have yet to demonstrate robust clinical responses. A key limitation may be the lack of patient selection strategies to identify those most likely to respond to treatment. To overcome this limitation, we screened a DR5 agonist Nanobody across >600 cell lines representing 21 tumor lineages and assessed molecular features associated with response. High expression of DR5 and Casp8 were significantly associated with sensitivity, but their expression thresholds were difficult to translate due to low dynamic ranges. To address the translational challenge of establishing thresholds of gene expression, we developed a classifier based on ratios of genes that predicted response across lineages. The ratio classifier outperformed the DR5+Casp8 classifier, as well as standard approaches for feature selection and classification using genes, instead of ratios. This classifier was independently validated using 11 primary patient-derived pancreatic xenograft models showing perfect predictions as well as a striking linearity between prediction probability and anti-tumor response. A network analysis of the genes in the ratio classifier captured important biological relationships mediating drug response, specifically identifying key positive and negative regulators of DR5 mediated apoptosis, including DR5, CASP8, BID, cFLIP, XIAP and PEA15. Importantly, the ratio classifier shows translatability across gene expression platforms (from Affymetrix microarrays to RNA-seq and across model systems (in vitro to in vivo. Our approach of using gene expression ratios presents a robust and novel method for constructing translatable biomarkers of compound response, which can also probe the underlying biology of treatment response.

  1. Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages.

    Science.gov (United States)

    Reddy, Anupama; Growney, Joseph D; Wilson, Nick S; Emery, Caroline M; Johnson, Jennifer A; Ward, Rebecca; Monaco, Kelli A; Korn, Joshua; Monahan, John E; Stump, Mark D; Mapa, Felipa A; Wilson, Christopher J; Steiger, Janine; Ledell, Jebediah; Rickles, Richard J; Myer, Vic E; Ettenberg, Seth A; Schlegel, Robert; Sellers, William R; Huet, Heather A; Lehár, Joseph

    2015-01-01

    Death Receptor 5 (DR5) agonists demonstrate anti-tumor activity in preclinical models but have yet to demonstrate robust clinical responses. A key limitation may be the lack of patient selection strategies to identify those most likely to respond to treatment. To overcome this limitation, we screened a DR5 agonist Nanobody across >600 cell lines representing 21 tumor lineages and assessed molecular features associated with response. High expression of DR5 and Casp8 were significantly associated with sensitivity, but their expression thresholds were difficult to translate due to low dynamic ranges. To address the translational challenge of establishing thresholds of gene expression, we developed a classifier based on ratios of genes that predicted response across lineages. The ratio classifier outperformed the DR5+Casp8 classifier, as well as standard approaches for feature selection and classification using genes, instead of ratios. This classifier was independently validated using 11 primary patient-derived pancreatic xenograft models showing perfect predictions as well as a striking linearity between prediction probability and anti-tumor response. A network analysis of the genes in the ratio classifier captured important biological relationships mediating drug response, specifically identifying key positive and negative regulators of DR5 mediated apoptosis, including DR5, CASP8, BID, cFLIP, XIAP and PEA15. Importantly, the ratio classifier shows translatability across gene expression platforms (from Affymetrix microarrays to RNA-seq) and across model systems (in vitro to in vivo). Our approach of using gene expression ratios presents a robust and novel method for constructing translatable biomarkers of compound response, which can also probe the underlying biology of treatment response.

  2. Modulation of interferon-gamma-induced HLA-DR expression on the human keratinocyte cell line SCC-13 by ultraviolet radiation

    International Nuclear Information System (INIS)

    Khan, I.U.; Boehm, K.D.; Elmets, C.A.

    1993-01-01

    Cell surface expression of major histocompatibility determinants on epidermal keratinocytes is a characteristic feature of a number of inflammatory dermatoses and in all likelihood is caused by diffusion of human leukocyte antigen (HLA)-DR-inducing cytokines from cells present in the dermal mononuclear cell infiltrate. Many of these same disorders respond to ultraviolet (UV) radiation phototherapy. Using the human SCC-13 keratinocyte cell line as a model, UV radiation was found to inhibit interferon-gamma-induced HLA-DR expression. Inhibition correlated closely with decreased steady-state levels of HLA-DR mRNA. These findings provide evidence that the therapeutic effect of UV radiation phototherapy may be mediated by its capacity to down-regulate cytokine-induced keratinocyte HLA-DR expression. (Author)

  3. THE MAN HAD LINGUISTICS LIKED: PROF. DR. DOĞAN AKSAN DİL BİLİMİNİ SEVDİREN ADAM: PROF. DR. DOĞAN AKSAN (1929-2010

    Directory of Open Access Journals (Sweden)

    Ahmet Turan SİNAN

    2010-10-01

    Full Text Available Who is the linguistics studies’ the one of innovators in Turkey, Prof. Dr. Doğan Aksan is very important scientist who fall in love with Turkish, reweal the richness and power of expression of our mother tangue. He displays a lot of European turcologits’ delussions as A. von Gabain, R. Giraud, J. Kramsky for Turkish with his studies. Aksan, who writes a lot of studies for shabbiness, semantic features, expression, flexibility of Turkish, Turkish education, takes place between founders of linguistic in Turkey. He displays the big love to Turkish by serving to Turkish in the light of the methods and techniques of universal linguistic. Prof. Dr. Doğan Aksan will be remember always as a very important scientist and the man had linguistics liked. Türkiye’deki dil bilim çalışmalarının öncülerinden olan Prof. Dr. Doğan Aksan; Türkçeye gönül vermiş, anlam bilim çalışmaları ile ana dilimizin zenginliğini ve anlatım gücünü gözler önüne seren çok önemli bir bilim adamıdır. Bu çalışmaları ile A. von Gabain, R. Giraud, J. Kramsky gibi birçok Avrupalı Türkologun Türkçeye yönelik yanılgılarını da ortaya koymuştur. Türkçenin eskiliğine, anlamsal özelliklerine, anlatım gücü ve esnekliğine, Türkçe öğretimine yönelik birçok esere imza atan Aksan, Türkiye’de dil bilimin kurucuları arasında yer alır. Türkçeye olan büyük sevgisini evrensel dil bilimin yöntem ve teknikleri ışığında hizmet ederek göstermiştir. Prof. Dr. Doğan Aksan, çok önemli bir bilim adamı ve her şeyden önce dil bilimi sevdiren kişi olarak daima hatırlanacaktır.

  4. Human radiation studies: Remembering the early years: Oral history of Dr. Patricia Wallace Durbin, Ph.D., conducted November 11, 1994

    International Nuclear Information System (INIS)

    1995-07-01

    This report is a transcript of an interview of Dr. Patricia Wallace Durbin by representatives of the US DOE Office of Human Radiation Research. Dr. Durbin was selected for this interview because of her knowledge of the human plutonium injections and her recollections of key figures, especially Joseph Hamilton. After a brief biographical sketch Dr. Durbin discusses her loss of research funding from DOE, her recollections concerning research into strontium metabolism as part of Project Sunshine, her recollections relating to the rationale for studies of human metabolism of radionuclides, her remembrances of Dr. Hamilton's Astatine and Plutonium research, and her experiences in gathering archival records concerning these researches

  5. Decommissioning of DR 2. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Strufe, N.

    2009-02-15

    This report describes the work of dismantling and demolishing reactor DR 2, the waste volumes generated, the health physical conditions and the clearance procedures used for removed elements and waste. Since the ultimate goal for the decommissioning project was not clearance of the building, but downgrading the radiological classification of the building with a view to converting it to further nuclear use, this report documents how the lower classification was achieved and the known occurrence of remaining activity. The report emphasises some of the deliberations made and describes the lessons learned through this decommissioning project. The report also intends to contribute towards the technical basis and experience basis for further decommissioning of the nuclear facilities in Denmark. (au)

  6. ORAC-DR: A generic data reduction pipeline infrastructure

    Science.gov (United States)

    Jenness, Tim; Economou, Frossie

    2015-03-01

    ORAC-DR is a general purpose data reduction pipeline system designed to be instrument and observatory agnostic. The pipeline works with instruments as varied as infrared integral field units, imaging arrays and spectrographs, and sub-millimeter heterodyne arrays and continuum cameras. This paper describes the architecture of the pipeline system and the implementation of the core infrastructure. We finish by discussing the lessons learned since the initial deployment of the pipeline system in the late 1990s.

  7. Improving College Students English Learning with Dr. Eye Android Mid

    Science.gov (United States)

    Yang, Ju Yin; Che, Pei-Chun

    2015-01-01

    This paper investigates college students' English language learning through use of Dr. Eye Android handheld mobile Internet device (MID). Compared to related studies, students' English learning using MIDs has not been evaluated and fully understood in the field of higher education. Quantitatively, the researchers used TOEIC pretest and posttest to…

  8. Neue Phoriden aus Belgisch-Kongo, gesammelt von Dr. Jos. Bequaert

    NARCIS (Netherlands)

    Schmitz, H.

    1916-01-01

    Durch die Güte des Herrn Dr. Jos. Bequaert konnte ich einige Phoriden untersuchen, die dieser eifrige Entomologe während seines letzten Aufenthalts am Kongo und im Ruwenzori-Gebirge gesammelt hat. Es lagen im ganzen 5 Arten vor, darunter zwei neue, die im folgenden beschrieben werden. Von den drei

  9. The Effects of Dr. Oz on Health Behaviors and Attitudes

    Science.gov (United States)

    Crouch, Elizabeth; Dickes, Lori A.; Davis, Amanda; Zarandy, Joy

    2016-01-01

    Background: Consumption of social media has quickly evolved into a primary source of health information for many consumers. This seems to be particularly true for individuals seeking to modify chronic health conditions like weight loss, obesity, and obesity-related diseases. Purpose: This study explores whether watching Dr. Oz weight loss episodes…

  10. Sub-Saharan Africa Report No. 2793.

    Science.gov (United States)

    1983-05-02

    Loans (TIMES OF ZAMBIA, 7 Apr 83) 55 IFC Suing Prime Minister for Alleged Failure To Repay 1974 Loan (DAILY MAIL, 7 Apr 83) 57 Zulu Calls...Partner’ 60 Indian Trade Delegation 60 FAO Famine Relief Donation 60 SIDO Members to FRG 60 Wage Increase Request 61 Zulu Warns Against Threats 61...deteriorat- ing rangelands of most countries in the near future, according to Dr. David Hop- craft, founder and managing director of Game Ranch

  11. JPRS Report East Asia Southeast Asia

    Science.gov (United States)

    1987-06-03

    Article by Jim Shrimpton] [Text] ON May 14,1879, a ship arrived in Fiji bring- ing 489 Indians to labour in the British-run sugar cane fields... Labour Coalition Government elected in April has a Fijian leader, Dr Timoci Bavadra, but 19 of its 28 members are Indians. The House of...overseas Vietnamese residing in the FRG: "Feelings of an Absentee "] [Text] Human memory is a wonderful faculty. When leaving Hanoi, I was only 6

  12. Driving Simulator Development and Performance Study

    OpenAIRE

    Juto, Erik

    2010-01-01

    The driving simulator is a vital tool for much of the research performed at theSwedish National Road and Transport Institute (VTI). Currently VTI posses three driving simulators, two high fidelity simulators developed and constructed by VTI, and a medium fidelity simulator from the German company Dr.-Ing. Reiner Foerst GmbH. The two high fidelity simulators run the same simulation software, developed at VTI. The medium fidelity simulator runs a proprietary simulation software. At VTI there is...

  13. A structural study of the interaction between the Dr haemagglutinin DraE and derivatives of chloramphenicol

    International Nuclear Information System (INIS)

    Pettigrew, David M.; Roversi, Pietro; Davies, Stephen G.; Russell, Angela J.; Lea, Susan M.

    2009-01-01

    The structures of two Dr adhesin (DraE) complexes with chloramphenicol derivatives, namely chloramphenicol succinate and bromamphenicol, have been solved. The structures reveal important functional groups for small-molecule binding and imply possible modifications to the molecule that would permit a more wide-ranging interaction without the toxic side effects associated with chloramphenicol. Dr adhesins are expressed on the surface of uropathogenic and diffusely adherent strains of Escherichia coli. The major adhesin subunit (DraE/AfaE) of these organelles mediates attachment of the bacterium to the surface of the host cell and possibly intracellular invasion through its recognition of the complement regulator decay-accelerating factor (DAF) and/or members of the carcinoembryonic antigen (CEA) family. The adhesin subunit of the Dr haemagglutinin, a Dr-family member, additionally binds type IV collagen and is inhibited in all its receptor interactions by the antibiotic chloramphenicol (CLM). In this study, previous structural work is built upon by reporting the X-ray structures of DraE bound to two chloramphenicol derivatives: chloramphenicol succinate (CLS) and bromamphenicol (BRM). The CLS structure demonstrates that acylation of the 3-hydroxyl group of CLM with succinyl does not significantly perturb the mode of binding, while the BRM structure implies that the binding pocket is able to accommodate bulkier substituents on the N-acyl group. It is concluded that modifications of the 3@@hydroxyl group would generate a potent Dr haemagglutinin inhibitor that would not cause the toxic side effects that are associated with the normal bacteriostatic activity of CLM

  14. A short life history of Prof. Dr. F.P. Jonker

    NARCIS (Netherlands)

    Janssen, C.R.

    1978-01-01

    This year Prof. Dr. F.P. Jonker, Frits as he is known among his friends, will retire from the formal academic life at the State University of Utrecht: a long and busy life of 49 years, devoted to teaching, administration, and scientific research. Looking back on all these years, one realises the

  15. Dr Julia King CBE FREng, Chief Executive Designate, Institute of Physics (United Kingdom), visiting the NA48 experiment.

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Photo 02: Visiting the NA48 experiment, Dr Julia King, Chief Executive Designate, Institute of Physics (Britain and Ireland) (right) with A. Ceccucci and K. Peach. Photo 05: Visiting the NA48 experiment, Dr Julia King, Chief Executive Designate, Institute of Physics (Britain and Ireland) (centre) with A. Ceccucci and C. Lazzeroni. Photo 08: Visiting the NA48 experiment, Dr Julia King, Chief Executive Designate, Institute of Physics (Britain and Ireland) (second from left) with (left to right) R. Barlow, J. Wood, N. McCubbin, K. Peach, A. Ceccucci, C. Lazzeroni, M. Patel and D. Munday.

  16. Une expérience pédagogique du débat public en école d'ingénieur. Le cas du nucléaire

    Directory of Open Access Journals (Sweden)

    Colmellere Cynthia

    2014-01-01

    Full Text Available Cette communication présente un dispositif pédagogique d'exercice de débat public autour d'un projet d'implantation d'un réacteur nucléaire. Cet exercice est mené depuis trois ans dans le cadre d'un cours de sociologie pour des ingénieurs de deuxième année à l'Ecole Centrale Paris. Il concerne un groupe d'une vingtaine d'élèves et s'inspire d'une situation réelle et actuelle : le projet d'implantation d'un réacteur nucléaire de type EPR à Penly (76. Dans cette contribution, nous présentons tout d'abord les enjeux de cette expérience pédagogique dans le contexte de notre établissement et les questions pédagogiques qu'elle pose. Dans une deuxième partie, nous détaillons les différentes séquences du cours qui servent à préparer ce débat. Dans la troisième, nous revenons sur le déroulement du débat et la phase de discussion critique entre les observateurs, les élèves et l'enseignante qui s'ensuit. Nous concluons sur les apports et les limites de cet exercice en les mettant en perspective avec les enjeux de l'enseignement des controverses scientifiques et techniques dans la formation des ingénieurs.

  17. Photographer: Digital Telepresence: Dr Murial Ross's Virtual Reality Application for Neuroscience

    Science.gov (United States)

    1995-01-01

    Photographer: Digital Telepresence: Dr Murial Ross's Virtual Reality Application for Neuroscience Research Biocomputation. To study human disorders of balance and space motion sickness. Shown here is a 3D reconstruction of a nerve ending in inner ear, nature's wiring of balance organs.

  18. [Dr. Sklenar's Kombucha mushroom infusion--a biological cancer therapy. Documentation No. 18].

    Science.gov (United States)

    Hauser, S P

    1990-02-27

    Kombucha, a fungal infusion, is a 'symbiotic mixture' of bacteria, yeasts, tea and sugar. A number of components are listed, but exact analyses are not published. On the basis of 'thorough detoxification', Kombucha is claimed to be a prophylactic and therapeutic agent in countless diseases, such as rheumatism, intestinal disorders, ageing and cancer. All 'stages of the Sklenar blood picture' have to be treated with Kombucha Drink, Kombucha Drops, coli preparations and Gelum oral-rd for a period of months. A litre-bottle costs 13 DM, the blood analysis 150 Sfr. In the 1960's Dr. R. Sklenar developed a 'biological cancer therapy with Kombucha as the main agent' and his own system of diagnosing cancer. Sklenar's diagnosis of cancer is based on iris diagnosis and demonstration of the causative organism by means of a 'Blood picture according to Dr. Sklenar'. He claims, on one hand, that cancer is only one of the many metabolic diseases and, on the other, that viruses, in his view parasitic microorganisms in general, are responsible for the pathogenesis of cancer. No preclinical and nor investigations are available, as 'success has proved him (Dr. Sklenar) to be right'. The seven 'case histories' described have no solid medical data. There is so far no evidence to support the claim that Kombucha offers 'effective biological treatment of cancer'.

  19. Dr. Robert G. Heath: a controversial figure in the history of deep brain stimulation.

    Science.gov (United States)

    O'Neal, Christen M; Baker, Cordell M; Glenn, Chad A; Conner, Andrew K; Sughrue, Michael E

    2017-09-01

    The history of psychosurgery is filled with tales of researchers pushing the boundaries of science and ethics. These stories often create a dark historical framework for some of the most important medical and surgical advancements. Dr. Robert G. Heath, a board-certified neurologist, psychiatrist, and psychoanalyst, holds a debated position within this framework and is most notably remembered for his research on schizophrenia. Dr. Heath was one of the first physicians to implant electrodes in deep cortical structures as a psychosurgical intervention. He used electrical stimulation in an attempt to cure patients with schizophrenia and as a method of conversion therapy in a homosexual man. This research was highly controversial, even prior to the implementation of current ethics standards for clinical research and often goes unmentioned within the historical narrative of deep brain stimulation (DBS). While distinction between the modern practice of DBS and its controversial origins is necessary, it is important to examine Dr. Heath's work as it allows for reflection on current neurosurgical practices and questioning the ethical implication of these advancements.

  20. Deletion mutant defines DQ beta variants with DR4 positive DQw3 positive haplotypes

    International Nuclear Information System (INIS)

    Nepom, B.S.; Kim, S.J.; Nepom, G.T.

    1986-01-01

    We describe the production of an HLA deletion mutation by radiation mutagenesis of a DR4- and DQw3-homozygous, Dw4- and Dw14-heterozygous cell line designed to analyze polymorphisms associated with DR4 and DQw3. Southern blot analysis confirms a deletion of class I and class II genes on one haplotype. Variation in DQ beta alleles associated with DQw3 was previously described by characteristic RFLP patterns for a DQ beta bene. One pattern, which correlated precisely with A-10-83 monoclonal antibody reactivity (TA10), defined an allele which we call DQ''3.1''. The mutant cell line has lost the polymorphic bands on Southern blots corresponding to the DQ''3.1'' allele, while the intact Dw14 haplotype retains the alternate allele at DQ beta which is DQw-3 positive. TA10-negative. These data demonstrate the segregation of two DQw3 positive DQ beta allelic variants, both associated with DR4, which can be distinguished on the basis of both RFLP and monoclonal antibody reactivity