WorldWideScience

Sample records for induce marked relocations

  1. Climate-induced community relocations: using integrated social-ecological assessments to foster adaptation and resilience

    Directory of Open Access Journals (Sweden)

    Robin Bronen

    2015-09-01

    Full Text Available Extreme weather events coupled with sea level rise and erosion will cause coastal and riverine areas where people live and maintain livelihoods to disappear permanently. Adaptation to these environmental changes, including the permanent relocation of millions of people, requires new governance tools. In the USA, local governments, often with state-level and national-level support, will be primarily responsible for protecting residents from climate-change impacts and implementing policies needed to protect their welfare. Government agencies have a variety of tools to facilitate protection in place and managed coastal retreat but have very limited tools to facilitate community relocation. In addition, no institutional mechanism currently exists to determine whether and when preventive relocation needs to occur to protect people from climate change impacts. Based on research involving four Alaska Native communities threatened by climate-induced environmental impacts, I propose the design and implementation of an adaptive governance framework to respond to the need to relocate populations. In this context, adaptive governance means the ability of institutions to dynamically respond to climate change impacts. A component of this adaptive governance framework is a social-ecological monitoring and assessment tool that can facilitate collaborative knowledge production by community residents and governance institutions to guide sustainable adaptation strategies and determine whether and when relocation needs to occur. The framework, including the monitoring and assessment tool, has not been systematically tested. However, the potential use of this tool is discussed by drawing on empirical examples of Alaskan communities faced with accelerating rates of erosion.

  2. Optical Marking of Alcohol Induced Hemoglobin Modification

    CERN Document Server

    Vlokh, R; Moroz, O; Nastishin, Yu; Dudok, K; Dudok, T; Grinchishin, N; Nechiporenko, I; Hul, A

    2007-01-01

    It has been shown that conformational modifications of Hb induced by ethanol consumption can be visualized in optical spectra studying oxygenation kinetics of hemoglobin or mixing hemoglobin with Cibacron blue dye. Better dye affinity of blood proteins extracted from alcoholised rats with respect to those from non-alcoholised ones confirms that ethanol and its metabolites induce structural pathologies in blood protein molecules. The detected changes for the case of the posterity of intoxicated animals may be explained as a post-translation modification, as well as a disturbance of the structure and function of tissue cellular gene mechanism for the blood creation. It is established that alcohol intake during first four months leads to the decrease of fractional weight of oxyhemoglobin and to the increase of methemoglobin amount in blood. Further alcohol consumption is accompanied by recovering of the normal level of hemoglobin derivatives in blood. Normalization of the fractional weight of hemoglobin derivati...

  3. Red Light-Induced Phytochrome Relocation into the Nucleus in Adiantum capillus-veneris

    Institute of Scientific and Technical Information of China (English)

    Hidenori Tsuboi; Sachihiko Nakamura; Eberhard Sch(a)fer; Masamitsu Wada

    2012-01-01

    Phytochromes in seed plants are known to move into nuclei in a red light-dependent manner with or without interacting factors.Here,we show phytochrome relocation to the nuclear region in phytochrome-dependent Adiantum capillus-veneris spore germination by partial spore-irradiation experiments.The nuclear or non-nuclear region of imbibed spores was irradiated with a microbeam of red and/or far-red light and the localization of phytochrome involved in spore germination was estimated from the germination rate.The phytochrome for spore germination existed throughout whole spore under darkness after imbibition,but gradually migrated to the nuclear region following red light irradiation.Intracellular distribution of PHY-GUS fusion proteins expressed in germinated spores by particle bombardment showed the migration of Acphy2,but not Acphy1,into nucleus in a red light-dependent manner,suggesting that Acphy2 is the photoreceptor for fern spore germination.

  4. Phototropin-dependent biased relocalization of cp-actin filaments can be induced even when chloroplast movement is inhibited.

    Science.gov (United States)

    Yamada, Noboru; Suetsugu, Noriyuki; Wada, Masamitsu; Kadota, Akeo

    2011-11-01

    In a recent publication using an actin-visualized line of Arabidopsis (Ichikawa et al. 2011, ref. 11), we reported a detailed analysis with higher time resolution on the dynamics of chloroplast actin filaments (cp-actin filaments) during chloroplast avoidance movement and demonstrated a good correlation between the biased configuration of cp-actin filaments and chloroplast movement. However, we could not conclusively determine whether the reorganization of cp-actin filaments into a biased configuration preceded actual chloroplast movement (and, thus, whether it could be a cause of the movement). In this report, we present clear evidence that the reorganization of cp-actin filaments into a biased distribution is induced even in the absence of the actual movement of chloroplasts. When the cells were treated with 2,3-butanedione monoxime (BDM), a potent inhibitor of myosin ATPase, chloroplast motility was completely suppressed. Nevertheless, the disappearance and biased relocalization of cp-actin filaments toward the side of the prospective movement direction were induced by irradiation with a strong blue light microbeam. The results definitively indicate that the reorganization of cp-actin filaments is not an effect of chloroplast movement; however, it is feasible that the biased localization of cp-actin filaments is an event leading to chloroplast movement.

  5. Angiotensin II infusion induces marked diaphragmatic skeletal muscle atrophy.

    Directory of Open Access Journals (Sweden)

    Bashir M Rezk

    Full Text Available Advanced congestive heart failure (CHF and chronic kidney disease (CKD are characterized by increased angiotensin II (Ang II levels and are often accompanied by significant skeletal muscle wasting that negatively impacts mortality and morbidity. Both CHF and CKD patients have respiratory muscle dysfunction, however the potential effects of Ang II on respiratory muscles are unknown. We investigated the effects of Ang II on diaphragm muscle in FVB mice. Ang II induced significant diaphragm muscle wasting (18.7±1.6% decrease in weight at one week and reduction in fiber cross-sectional area. Expression of the E3 ubiquitin ligases atrogin-1 and muscle ring finger-1 (MuRF-1 and of the pro-apoptotic factor BAX was increased after 24 h of Ang II infusion (4.4±0.3 fold, 3.1±0.5 fold and 1.6±0.2 fold, respectively, compared to sham infused control suggesting increased muscle protein degradation and apoptosis. In Ang II infused animals, there was significant regeneration of injured diaphragm muscles at 7 days as indicated by an increase in the number of myofibers with centralized nuclei and high expression of embryonic myosin heavy chain (E-MyHC, 11.2±3.3 fold increase and of the satellite cell marker M-cadherin (59.2±22.2% increase. Furthermore, there was an increase in expression of insulin-like growth factor-1 (IGF-1, 1.8±0.3 fold increase in Ang II infused diaphragm, suggesting the involvement of IGF-1 in diaphragm muscle regeneration. Bone-marrow transplantation experiments indicated that although there was recruitment of bone-marrow derived cells to the injured diaphragm in Ang II infused mice (267.0±74.6% increase, those cells did not express markers of muscle stem cells or regenerating myofibers. In conclusion, Ang II causes marked diaphragm muscle wasting, which may be important for the pathophysiology of respiratory muscle dysfunction and cachexia in conditions such as CHF and CKD.

  6. Characteristics of Induced and Tectonic Seismicity in Oklahoma Based on High-precision Earthquake Relocations and Focal mechanisms

    Science.gov (United States)

    Aziz Zanjani, F.; Lin, G.

    2016-12-01

    Seismic activity in Oklahoma has greatly increased since 2013, when the number of wastewater disposal wells associated with oil and gas production was significantly increased in the area. An M5.8 earthquake at about 5 km depth struck near Pawnee, Oklahoma on September 3, 2016. This earthquake is postulated to be related with the anthropogenic activity in Oklahoma. In this study, we investigate the seismic characteristics in Oklahoma by using high-precision earthquake relocations and focal mechanisms. We acquire the seismic data between January 2013 and October 2016 recorded by the local and regional (within 200 km distance from the Pawnee mainshock) seismic stations from the Incorporated Research Institutions for Seismology (IRIS). We relocate all the earthquakes by applying the source-specific station term method and a differential time relocation method based on waveform cross-correlation data. The high-precision earthquake relocation catalog is then used to perform full-waveform modeling. We use Muller's reflection method for Green's function construction and the mtinvers program for moment tensor inversion. The sensitivity of the solution to the station and component distribution is evaluated by carrying out the Jackknife resampling. These earthquake relocation and focal mechanism results will help constrain the fault orientation and the earthquake rupture length. In order to examine the static Coulomb stress change due to the 2016 Pawnee earthquake, we utilize the Coulomb 3 software in the vicinity of the mainshock and compare the aftershock pattern with the calculated stress variation. The stress change in the study area can be translated into probability of seismic failure on other parts of the designated fault.

  7. Caffeine Markedly Enhanced Radiation-Induced Bystander Effects

    Science.gov (United States)

    Jiang, Erkang; Wu, Lijun

    2009-04-01

    In this paper it is shown that incubation with 2 mM caffeine enhanced significantly the MN (micronucleus) formation in both the 1 cGy α-particle irradiated and non-irradiated bystander regions. Moreover, caffeine treatment made the non-irradiated bystander cells more sensitive to damage signals. Treated by c-PTIO(2-(4-carboxy-phenyl)-4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide), a nitric oxide (NO) scavenger, the MN frequencies were effectively inhibited, showing that nitric oxide might be very important in mediating the enhanced damage. These results indicated that caffeine enhanced the low dose α-particle radiation-induced damage in irradiated and non-irradiated bystander regions, and therefore it is important to investigate the relationship between the radiosensitizer and radiation-induced bystander effects (RIBE).

  8. Caffeine Markedly Enhanced Radiation-Induced Bystander Effects

    Institute of Scientific and Technical Information of China (English)

    JIANG Erkang; WU Lijun

    2009-01-01

    A bstract In this paper it is shown that incubation with 2 mM caffeine enhanced significantly the MN (micronucleus) formation in both the 1 cGy a-particle irradiated and non-irradiated by- stander regions. Moreover, caffeine treatment made the non-irradiated bystander cells more sensi- tive to damage signals. Treated by c-PTIO(2-(4-carboxy-phenyl)-4,4,5,5-tetramethyl-imidazoline- 1-oxyl-3-oxide), a nitric oxide (NO) scavenger, the MN frequencies were effectively inhibited, showing that nitric oxide might be very important in mediating the enhanced damage. These results indicated that caffeine enhanced the low dose a-particle radiation-induced damage in ir- radiated and non-irradiated bystander regions, and therefore it is important to investigate the relationship between the radiosensitizer and radiation-induced bystander effects (RIBE).

  9. Shigella effector IpaB-induced cholesterol relocation disrupts the Golgi complex and recycling network to inhibit host cell secretion.

    Science.gov (United States)

    Mounier, Joëlle; Boncompain, Gaëlle; Senerovic, Lidija; Lagache, Thibault; Chrétien, Fabrice; Perez, Franck; Kolbe, Michael; Olivo-Marin, Jean-Christophe; Sansonetti, Philippe J; Sauvonnet, Nathalie

    2012-09-13

    Shigella infection causes destruction of the human colonic epithelial barrier. The Golgi network and recycling endosomes are essential for maintaining epithelial barrier function. Here we show that Shigella epithelial invasion induces fragmentation of the Golgi complex with consequent inhibition of both secretion and retrograde transport in the infected host cell. Shigella induces tubulation of the Rab11-positive compartment, thereby affecting cell surface receptor recycling. The molecular process underlying the observed damage to the Golgi complex and receptor recycling is a massive redistribution of plasma membrane cholesterol to the sites of Shigella entry. IpaB, a virulence factor of Shigella that is known to bind cholesterol, is necessary and sufficient to induce Golgi fragmentation and reorganization of the recycling compartment. Shigella infection-induced Golgi disorganization was also observed in vivo, suggesting that this mechanism affecting the sorting of cell surface molecules likely contributes to host epithelial barrier disruption associated with Shigella pathogenesis. Copyright © 2012 Elsevier Inc. All rights reserved.

  10. Caspase-independent apoptosis in Friend's erythroleukemia cells: role of mitochondrial ATP synthesis impairment in relocation of apoptosis-inducing factor and endonuclease G.

    Science.gov (United States)

    Comelli, Marina; Genero, Nadia; Mavelli, Irene

    2009-02-01

    Mitochondria have emerged as the central components of both caspase-dependent and independent apoptosis signalling pathways through release of different apoptogenic proteins. We previously documented that parental and differentiated Friend's erythroleukemia cells were induced to apoptosis by oligomycin and H(2)O(2) exposure, showing that the energy impairment occurring in both cases as a consequence of a severe mitochondrial F(0)F(1)ATPsynthase inactivation was a common early feature. Here we provide evidence for AIF and Endo G mitochondrio-nuclear relocation in both cases, as a component of caspase-independent apoptosis pathways. No detectable change in mitochondrial transmembrane potential and no variation in mitochondrial levels of Bcl-2 and Bax are observed. These results point to the osmotic rupture of the mitochondrial outer membrane as occurring in response to cell exposure to the two energy-impairing treatments under conditions preserving the mitochondrial inner membrane. A critical role of the mitochondrial F(0)F(1)ATP synthase inhibition in this process is also suggested.

  11. MARK2 Rescues Nogo-66-Induced Inhibition of Neurite Outgrowth via Regulating Microtubule-Associated Proteins in Neurons In Vitro.

    Science.gov (United States)

    Zuo, Yu-Chao; Xiong, Nan-Xiang; Shen, Jian-Ying; Yu, Hua; Huang, Yi-Zhi; Zhao, Hong-Yang

    2016-11-01

    The ability of neurons in the adult mammalian central nervous system (CNS) to regenerate after injury is limited by inhibitors in CNS myelin. Nogo-66 is the most important myelin inhibitor but the mechanisms of Nogo-66 inhibition of neurite outgrowth remain poorly understood. Particularly, the relationship between Nogo-66 and microtubule-affinity regulating kinase 2 (MARK2) has not been examined. This study investigated the role of MARK2 in Nogo-66 inhibition and the function of MARK2 in neurite elongation in neurons in vitro. MARK2 and phosphorylated MARK2 at Ser212 (p-Ser212) alterations in Neuro 2a cells were assessed at different Nogo-66 exposure times; the relationships between MARK2 and microtubule-associated proteins (MAPs) were determined via the overexpression or interference of MARK2. Our study reports that Nogo-66 inhibited the expression of total MARK2 but also reduced Ser212 phosphorylation of MARK2, whereas levels of MAP1-b and tau varied depending on MARK2 overexpression or reduced expression. Furthermore, MARK2 increased the proportion of tyrosinated α-tubulin, thereby disrupting the stability of tubulin, most likely affecting axonal growth. In line with these results, overexpression of MARK2 promoted neurite elongation and therefore is able to rescue the inhibitory effect of Nogo-66 on neurite growth. In conclusion, the intracellular PKB/MARK2/MAPs/α-tubulin pathway appears to be essential for neurite elongation in neurons in vitro. These results suggest a critical role for MARK2 in overcoming Nogo-66-induced inhibition of axon outgrowth in neurons. Pharmacological activators of MARK2 may be applicable to promote successful axonal outgrowth following many types of CNS injuries.

  12. 25 CFR 700.93 - Relocation plan.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Relocation plan. 700.93 Section 700.93 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES General Policies and Instructions Definitions § 700.93 Relocation plan. The relocation plan shall be the plan...

  13. Stadium Relocation in Professional Football

    DEFF Research Database (Denmark)

    Junghagen, Sven; Lillo, Gonzalo Leal

    The aim of this paper is to conceptually illustrate the tension between commercialisation and club authenticity, which is a potential consequence of stadium relocation. There is a commercial pressure for relocating a football club to new and more modern facilities, but also a pressure from...

  14. Diethylene glycol-induced toxicities show marked threshold dose response in rats

    Energy Technology Data Exchange (ETDEWEB)

    Landry, Greg M., E-mail: Landry.Greg@mayo.edu [Department of Pharmacology, Toxicology, & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA (United States); Dunning, Cody L., E-mail: cdunni@lsuhsc.edu [Department of Pharmacology, Toxicology, & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA (United States); Abreo, Fleurette, E-mail: fabreo@lsuhsc.edu [Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA (United States); Latimer, Brian, E-mail: blatim@lsuhsc.edu [Department of Pharmacology, Toxicology, & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA (United States); Orchard, Elysse, E-mail: eorcha@lsuhsc.edu [Department of Pharmacology, Toxicology, & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA (United States); Division of Animal Resources, Louisiana State University Health Sciences Center, Shreveport, LA (United States); McMartin, Kenneth E., E-mail: kmcmar@lsuhsc.edu [Department of Pharmacology, Toxicology, & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA (United States)

    2015-02-01

    Diethylene glycol (DEG) exposure poses risks to human health because of widespread industrial use and accidental exposures from contaminated products. To enhance the understanding of the mechanistic role of metabolites in DEG toxicity, this study used a dose response paradigm to determine a rat model that would best mimic DEG exposure in humans. Wistar and Fischer-344 (F-344) rats were treated by oral gavage with 0, 2, 5, or 10 g/kg DEG and blood, kidney and liver tissues were collected at 48 h. Both rat strains treated with 10 g/kg DEG had equivalent degrees of metabolic acidosis, renal toxicity (increased BUN and creatinine and cortical necrosis) and liver toxicity (increased serum enzyme levels, centrilobular necrosis and severe glycogen depletion). There was no liver or kidney toxicity at the lower DEG doses (2 and 5 g/kg) regardless of strain, demonstrating a steep threshold dose response. Kidney diglycolic acid (DGA), the presumed nephrotoxic metabolite of DEG, was markedly elevated in both rat strains administered 10 g/kg DEG, but no DGA was present at 2 or 5 g/kg, asserting its necessary role in DEG-induced toxicity. These results indicate that mechanistically in order to produce toxicity, metabolism to and significant target organ accumulation of DGA are required and that both strains would be useful for DEG risk assessments. - Highlights: • DEG produces a steep threshold dose response for kidney injury in rats. • Wistar and F-344 rats do not differ in response to DEG-induced renal injury. • The dose response for renal injury closely mirrors that for renal DGA accumulation. • Results demonstrate the importance of DGA accumulation in producing kidney injury.

  15. Marek’s disease virus infection induces widespread differential chromatin marks in inbred chicken lines

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    Mitra Apratim

    2012-10-01

    Full Text Available Abstract Background Marek’s disease (MD is a neoplastic disease in chickens caused by the MD virus (MDV. Successful vaccine development against MD has resulted in increased virulence of MDV and the understanding of genetic resistance to the disease is, therefore, crucial to long-term control strategies. Also, epigenetic factors are believed to be one of the major determinants of disease response. Results Here, we carried out comprehensive analyses of the epigenetic landscape induced by MDV, utilizing genome-wide histone H3 lysine 4 and lysine 27 trimethylation maps from chicken lines with varying resistance to MD. Differential chromatin marks were observed on genes previously implicated in the disease such as MX1 and CTLA-4 and also on genes reported in other cancers including IGF2BP1 and GAL. We detected bivalent domains on immune-related transcriptional regulators BCL6, CITED2 and EGR1, which underwent dynamic changes in both lines as a result of MDV infection. In addition, putative roles for GAL in the mechanism of MD progression were revealed. Conclusion Our results confirm the presence of widespread epigenetic differences induced by MD in chicken lines with different levels of genetic resistance. A majority of observed epigenetic changes were indicative of increased levels of viral infection in the susceptible line symptomatic of lowered immunocompetence in these birds caused by early cytolytic infection. The GAL system that has known anti-proliferative effects in other cancers is also revealed to be potentially involved in MD progression. Our study provides further insight into the mechanisms of MD progression while revealing a complex landscape of epigenetic regulatory mechanisms that varies depending on host factors.

  16. Bite marks in mink—Induced experimentally and as reflection of aggressive encounters between mink

    DEFF Research Database (Denmark)

    Hansen, Steffen W; Møller, Steen Henrik; Damgaard, Birthe Marie

    2014-01-01

    by an artificial tooth. Before pressure wasapplied, each mink was anaesthetized and pain treated.In order to investigate when bite marks from cage mates are inflicted and to what extendthey accumulate over time, 120 brown and 40 white juvenile mink were placed in groupsof four in climbing cages after weaning......, the pelt during the growth phase of the winter coat will producemarks that can be recognized as bite marks at pelting, (2) bite marks applied experimentally by use of an artificial tooth or occurring due to social/aggressive interactions (bites)between mink are only visible if pressure/bite on the mink......: (1) experimentally applied pressure on the skin can be recog-nized as bite marks in brown mink at pelting, (2) bite marks are easier to detect on brownmink than on white coloured mink (P tooth or occurring due to social...

  17. White-tailed jackrabbit relocation

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This memo summarizes a plan to relocate white-tailed jackrabbits to Walnut Creek National Wildlife Refuge (Neal Smith National Wildlife Refuge) during 1997.

  18. VEGF receptor blockade markedly reduces retinal microglia/macrophage infiltration into laser-induced CNV.

    Directory of Open Access Journals (Sweden)

    Hu Huang

    Full Text Available Although blocking VEGF has a positive effect in wet age-related macular degeneration (AMD, the effect of blocking its receptors remains unclear. This was an investigation of the effect of VEGF receptor (VEGFR 1 and/or 2 blockade on retinal microglia/macrophage infiltration in laser-induced choroidal neovascularization (CNV, a model of wet AMD. CNV lesions were isolated by laser capture microdissection at 3, 7, and 14 days after laser and analyzed by RT-PCR and immunofluorescence staining for mRNA and protein expression, respectively. Neutralizing antibodies for VEGFR1 or R2 and the microglia inhibitor minocycline were injected intraperitoneally (IP. Anti-CD11b, CD45 and Iba1 antibodies were used to confirm the cell identity of retinal microglia/macrophage, in the RPE/choroidal flat mounts or retinal cross sections. CD11b(+, CD45(+ or Iba1(+ cells were counted. mRNA of VEGFR1 and its three ligands, PlGF, VEGF-A (VEGF and VEGF-B, were expressed at all stages, but VEGFR2 were detected only in the late stage. PlGF and VEGF proteins were expressed at 3 and 7 days after laser. Anti-VEGFR1 (MF1 delivered IP 3 days after laser inhibited infiltration of leukocyte populations, largely retinal microglia/macrophage to CNV, while anti-VEGFR2 (DC101 had no effect. At 14 days after laser, both MF1 and DC101 antibodies markedly inhibited retinal microglia/macrophage infiltration into CNV. Therefore, VEGFR1 and R2 play differential roles in the pathogenesis of CNV: VEGFR1 plays a dominant role at 3 days after laser; but both receptors play pivotal roles at 14 days after laser. In vivo imaging demonstrated accumulation of GFP-expressing microglia into CNV in both CX3CR1(gfp/gfp and CX3CR1(gfp/+ mice. Minocycline treatment caused a significant increase in lectin(+ cells in the sub-retinal space anterior to CNV and a decrease in dextran-perfused neovessels compared to controls. Targeting the chemoattractant molecules that regulate trafficking of retinal microglia

  19. Organizational Relocation: A Field Perspective.

    Science.gov (United States)

    1980-11-01

    economy -- the only possible basis of a long-term survival system. This thrust gene - rates expansion in detailed planning requirements. Coordination...UNCLASSIFIED Dobson, William C. Jr., and Edwin H. Harris, Jr. ranizational Relocation: A Field Perspective. North Carolina Department of Cime Control

  20. Corporate relocation in venture capital finance

    NARCIS (Netherlands)

    D. Cumming; G. Flemming; A. Schwienbacher

    2009-01-01

    This paper introduces an analysis of international relocation decisions of venture capital (VC)-backed companies. Relocations to the United States are motivated by economic conditions as well as an improvement in the laws of the country in which the entrepreneurial firm is based. Relocations to the

  1. Electroporation markedly improves Sleeping Beauty transposon-induced tumorigenesis in mice.

    Science.gov (United States)

    Jung, S; Choi, H-J; Park, H-K; Jo, W; Jang, S; Ryu, J-E; Kim, W-J; Yu, E-S; Son, W-C

    2014-08-01

    The Sleeping Beauty (SB) transposon system is an important tool for genetic studies. It is used to insert a gene of interest into the host chromosome, thus enabling permanent gene expression. However, this system is less useful in higher eukaryotes because the transposition frequency is low. Efforts to improve the efficacy of the SB transposon system have focused on the method of gene delivery, but although electroporation has recently attracted much attention as an in vivo gene delivery tool, the simultaneous use of electroporation and the SB transposon system has not been studied for gene transfer in mice. In this study, electroporation was used in a model of SB transposon-induced insertional tumorigenesis. Electroporation increased the rate of tumor development to three times that of the control group. There was no difference in phenotype between tumors induced with the SB transposon system alone and those induced by the SB transposon and electroporation. Electroporation therefore may be an efficient means of improving the efficacy of gene transfer via the SB transposon system.

  2. The tyrosine kinase inhibitor dasatinib induces a marked adipogenic differentiation of human multipotent mesenchymal stromal cells.

    Directory of Open Access Journals (Sweden)

    Adriana Borriello

    Full Text Available BACKGROUND: The introduction of specific BCR-ABL inhibitors in chronic myelogenous leukemia therapy has entirely mutated the prognosis of this hematologic cancer from being a fatal disorder to becoming a chronic disease. Due to the probable long lasting treatment with tyrosine-kinase inhibitors (TKIs, the knowledge of their effects on normal cells is of pivotal importance. DESIGN AND METHODS: We investigated the effects of dasatinib treatment on human bone marrow-derived mesenchymal stromal cells (MSCs. RESULTS: Our findings demonstrate, for the first time, that dasatinib induces MSCs adipocytic differentiation. Particularly, when the TKI is added to the medium inducing osteogenic differentiation, a high MSCs percentage acquires adipocytic morphology and overexpresses adipocytic specific genes, including PPARγ, CEBPα, LPL and SREBP1c. Dasatinib also inhibits the activity of alkaline phosphatase, an osteogenic marker, and remarkably reduces matrix mineralization. The increase of PPARγ is also confirmed at protein level. The component of osteogenic medium required for dasatinib-induced adipogenesis is dexamethasone. Intriguingly, the increase of adipocytic markers is also observed in MSCs treated with dasatinib alone. The TKI effect is phenotype-specific, since fibroblasts do not undergo adipocytic differentiation or PPARγ increase. CONCLUSIONS: Our data demonstrate that dasatinib treatment affects bone marrow MSCs commitment and suggest that TKIs therapy might modify normal phenotypes with potential significant negative consequences.

  3. The Soviet Crisis Relocation Program.

    Science.gov (United States)

    1983-05-01

    347 / start the relocation is given.- Natural lv these ,lmcnits will also have priority in the us of transportation. Ilbh All the above elements of...necessari lv apply onl\\ to persn1S assigned to hosting areas nearest to the cities, and it does riot mean that such evacuees will be expected to walk...Onatskiy, "The Development of Consumer Goods Production," Voprosy Ekonomiki (Questions of Economics), No. 11, November 1971, p. 22. 122. G.B. Polyak

  4. Marked inhibition of hepatic cytochrome P450 activity in cholesterol-induced atherosclerosis in rabbits.

    Science.gov (United States)

    Irizar, A; Ioannides, C

    1998-04-03

    The objective of the present study was to investigate the expression of major xenobiotic-metabolising cytochrome P450 proteins, and of other enzyme systems, in hepatic and extrahepatic tissues of rabbits rendered atherosclerotic by the dietary administration of 1% cholesterol diets for 8 weeks. Individual cytochrome P450 proteins were monitored using diagnostic substrates and immunologically in Western blot analysis. The activity of all hepatic isoforms studied was depressed in the atherosclerotic animals; when, however, apoprotein levels were determined immunologically, no major differences were evident between the control and the atherosclerotic rabbits. In vitro studies indicated that neither cholesterol nor palm oil inhibited cytochrome P450 activity. The effects of cholesterol treatment leading to atherosclerosis on kidney, heart and lung cytochrome P450 activities were isoform- and tissue-specific; no change was evident in the heart activities, but in the lung and kidney cytochrome P450 activities were clearly modulated by the treatment with cholesterol. Apoprotein levels did not always parallel the changes in activities. Western blot analysis of aortic cytochromes P450 revealed that administration of cholesterol-rich diets enhanced CYP2B and CYP3A apoprotein levels. Cholesterol feeding to rabbits gave rise to a marked decrease in hepatic glutathione S-transferase activity but did not influence glutathione reductase or total glutathione levels. The same treatment had no effect on catalase, glutathione peroxidase and superoxide dismutase. It is concluded that treatment of rabbits with cholesterol-rich diets leading to atherosclerosis gives rise to profound changes in the expression of cytochrome P450 proteins in the liver and other tissues; possible mechanisms are discussed.

  5. Protein kinase C epsilon induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism.

    Science.gov (United States)

    Montgomery, David E; Rundell, Veronica L M; Goldspink, Paul H; Urboniene, Dalia; Geenen, David L; de Tombe, Pieter P; Buttrick, Peter M

    2005-11-01

    Myofilament dysfunction is a common point of convergence for many forms of heart failure. Recently, we showed that cardiac overexpression of PKC epsilon initially depresses myofilament activity and then leads to a progression of changes characteristic of human heart failure. Here, we examined the effects of PKC epsilon on contractile reserve, Starling mechanism, and myofilament activation in this model of end-stage dilated cardiomyopathy. Pressure-volume loop analysis and echocardiography showed that the PKC epsilon mice have markedly compromised systolic function and increased end-diastolic volumes. Dobutamine challenge resulted in a small increase in contractility in PKC epsilon mice but failed to enhance cardiac output. The PKC epsilon mice showed a normal length-dependent tension development in skinned cardiac muscle preparations, although Frank-Starling mechanism appeared to be compromised in the intact animal. Simultaneous measurement of tension and ATPase demonstrated that the maximum tension and ATPase were markedly lower in the PKC epsilon mice at any length or Ca2+ concentration. However, the tension cost was also lower indicating less energy expenditure. We conclude 1) that prolonged overexpression of PKC epsilon ultimately leads to a dilated cardiomyopathy marked by exhausted contractile reserve, 2) that PKC epsilon does not compromise the Frank-Starling mechanism at the myofilament level, and 3) that the Starling curve excursion is limited by the inotropic state of the heart. These results reflect the significance of the primary myofilament contractilopathy induced by phosphorylation and imply a role for PKC epsilon-mediated phosphorylation in myofilament physiology and the pathophysiology of decompensated cardiac failure.

  6. Zinc mesoporphyrin induces rapid and marked degradation of the transcription factor Bach1 and up-regulates HO-1.

    Science.gov (United States)

    Hou, Weihong; Shan, Ying; Zheng, Jianyu; Lambrecht, Richard W; Donohue, Susan E; Bonkovsky, Herbert L

    2008-03-01

    Heme oxygenase 1 (HO-1) is the first and rate-controlling enzyme in heme degradation. Bach1 is a mammalian transcriptional repressor of HO-1. To understand how zinc mesoporphyrin (ZnMP) induces the expression of HO-1, we investigated the effects of ZnMP on Bach1 mRNA and protein levels in human hepatoma Huh-7 cells by quantitative RT-PCR and Western blots. We found that ZnMP markedly up-regulated HO-1 mRNA and protein levels, and rapidly and significantly decreased Bach1 protein levels by increasing degradation of Bach1 protein [half life (t(1/2)) from 19 h to 45 min], whereas ZnMP did not influence Bach1 mRNA levels. The proteasome inhibitors, epoxomicin and MG132, significantly inhibited degradation of Bach1 by ZnMP in a dose-dependent fashion, indicating that the degradation of Bach1 by ZnMP is proteasome-dependent. Purified Bach1 C-terminal fragment bound heme, but there was no evidence for binding of ZnMP to the heme-binding region of Bach1. In conclusion, ZnMP produces profound post-transcriptional down-regulation of Bach1 protein levels and transcriptional up-regulation of HO-1. Our results indicate that ZnMP up-regulates HO-1 gene expression by markedly increasing Bach1 protein degradation in a proteasome-dependent manner.

  7. LAND SURVEY AND ASSESSMENT FOR RELOCATION

    OpenAIRE

    Hung, Chia-Hung; LIN, Han-Liliang; YAO, Chia-Jun

    2012-01-01

    The Construction and Planning Agency, Ministry of the Interior, called for the meeting of “Proper village relocation in response to the ‘Efforts of August 8 Flood Rescue and Reconstruction’” on Aug 19 2009 to confirm the subsequent house reconstruction operations and the activation of initial survey procedure of permanent relocation sites. The “site safety survey group” was established immediately after the meeting to start the safety evaluation and survey of the sites of permanent relocation...

  8. Laser marking on soda-lime glass by laser-induced backside wet etching with two-beam interference

    Science.gov (United States)

    Nakazumi, Tomoka; Sato, Tadatake; Narazaki, Aiko; Niino, Hiroyuki

    2016-09-01

    For crack-free marking of glass materials, a beam-scanning laser-induced backside wet etching (LIBWE) process by a beam spot with a fine periodic structure was examined. The fine periodic structure was produced within a beam spot by means of a Mach-Zehnder interferometer incorporated to the optical setup for the beam-scanning LIBWE. A fine structure with a period of 9 µm was observed within the microstructures with a diameter of ca. 40 µm fabricated by a laser shot under double-beam irradiation, and they could be homogeneously fabricated within an area of 800  ×  800 µm. The area filled with the microstructures, including fine periodic structures, could be observed in high contrast under a diffuse, on-axis illumination that was used in commercial QR code readers.

  9. Stretch Marks

    Science.gov (United States)

    ... to get rid of stretch marks, but the truth is that most don't work and are ... The Nemours Foundation, iStock, Getty Images, Corbis, Veer, Science Photo Library, Science Source Images, Shutterstock, and Clipart. ...

  10. Stretch marks

    Science.gov (United States)

    Stretch marks can appear when there is rapid stretching of the skin. They are often seen when ... often disappear after the cause of the skin stretching is gone. Avoiding rapid weight gain helps reduce ...

  11. Law, Morality and the Relocation Camps.

    Science.gov (United States)

    Stearns, Hal

    1990-01-01

    Presents a lesson examining the historical background of the U.S. government's relocation and internment of Japanese-Americans and Japanese aliens during World War II. Asks secondary students to consider both the legal and moral dimensions of the relocation effort and current compensation arguments. Includes handouts and suggestions for role…

  12. Cerebrolysin, a mixture of neurotrophic factors induces marked neuroprotection in spinal cord injury following intoxication of engineered nanoparticles from metals.

    Science.gov (United States)

    Menon, Preeti Kumaran; Muresanu, Dafin Fior; Sharma, Aruna; Mössler, Herbert; Sharma, Hari Shanker

    2012-02-01

    Spinal cord injury (SCI) is the world's most disastrous disease for which there is no effective treatment till today. Several studies suggest that nanoparticles could adversely influence the pathology of SCI and thereby alter the efficacy of many neuroprotective agents. Thus, there is an urgent need to find suitable therapeutic agents that could minimize cord pathology following trauma upon nanoparticle intoxication. Our laboratory has been engaged for the last 7 years in finding suitable therapeutic strategies that could equally reduce cord pathology in normal and in nanoparticle-treated animal models of SCI. We observed that engineered nanoparticles from metals e.g., aluminum (Al), silver (Ag) and copper (Cu) (50-60 nm) when administered in rats daily for 7 days (50 mg/kg, i.p.) resulted in exacerbation of cord pathology after trauma that correlated well with breakdown of the blood-spinal cord barrier (BSCB) to serum proteins. The entry of plasma proteins into the cord leads to edema formation and neuronal damage. Thus, future drugs should be designed in such a way to be effective even when the SCI is influenced by nanoparticles. Previous research suggests that a suitable combination of neurotrophic factors could induce marked neuroprotection in SCI in normal animals. Thus, we examined the effects of a new drug; cerebrolysin that is a mixture of different neurotrophic factors e.g., brain-derived neurotrophic factor (BDNF), glial cell line derived neurotrophic factor (GDNF), nerve growth factor (NGF), ciliary neurotrophic factor (CNTF) and other peptide fragments to treat normal or nanoparticle-treated rats after SCI. Our observations showed that cerebrolysin (2.5 ml/kg, i.v.) before SCI resulted in good neuroprotection in normal animals, whereas nanoparticle-treated rats required a higher dose of the drug (5.0 ml/kg, i.v.) to induce comparable neuroprotection in the cord after SCI. Cerebrolysin also reduced spinal cord water content, leakage of plasma proteins

  13. 5 CFR 575.209 - Payment of relocation incentives.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Payment of relocation incentives. 575.209... RECRUITMENT, RELOCATION, AND RETENTION INCENTIVES; SUPERVISORY DIFFERENTIALS; AND EXTENDED ASSIGNMENT INCENTIVES Relocation Incentives § 575.209 Payment of relocation incentives. (a) An authorized agency...

  14. 76 FR 16629 - Federal Travel Regulation (FTR); Relocation Allowances-Relocation Income Tax Allowance (RITA) Tables

    Science.gov (United States)

    2011-03-24

    ... http://www.gsa.gov/relocationpolicy . Dated: March 21, 2011. Janet Dobbs, Director, Office of Travel... ADMINISTRATION Federal Travel Regulation (FTR); Relocation Allowances-- Relocation Income Tax Allowance (RITA... effective March 24, 2011. FOR FURTHER INFORMATION CONTACT: Mr. Ed Davis, Office of Governmentwide Policy...

  15. CMS DT Upgrade The Sector Collector Relocation

    CERN Document Server

    Navarro Tobar, Alvaro

    2015-01-01

    The Sector Collector relocation is the first stage of the upgrade program for the Drift Tubes subdetector of the CMS experiment. It was accomplished during Long Shutdown 2013-2014, and consisted in the relocation of the second-level trigger and readout electronics from the experimental to the service cavern, relieving the environmental constraints and improving accessibility for maintenance and upgrade. Extending the electrical links would degrade reliability, so the information is converted to optical with a custom system capable of dealing with the DC-unbalanced data. Initially, present electronics are used, so optical-to-copper conversion has also been installed.

  16. Relocating a Company within the EU

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2008-01-01

    This article analyses how a public or private limited company can be relocated in another EU country via establishment of a subsidiary in the second country, followed by a reverse vertical merger (the parent ceases to exist and the subsidiary is the continuing company). The consideration for the ......This article analyses how a public or private limited company can be relocated in another EU country via establishment of a subsidiary in the second country, followed by a reverse vertical merger (the parent ceases to exist and the subsidiary is the continuing company). The consideration...

  17. Coping with disaster: relocating a residency program.

    Science.gov (United States)

    Conlay, Lydia A; Searle, Nancy S; Gitlin, Melvin C

    2007-08-01

    In September 2005, in the aftermath of Hurricane Katrina, the Tulane University School of Medicine relocated temporarily from New Orleans to the Baylor College of Medicine in Houston, Texas. For Tulane's residency program in anesthesiology, a training consortium was formed in Texas consisting of the University of Texas at Houston, Baylor College of Medicine, the University of Texas Medical Branch at Galveston, and the M.D. Anderson Cancer Center. The authors explain the collaborative process that allowed the consortium to find spaces to accommodate Tulane's 30 anesthesiology residents within 30 days after they left New Orleans, and they offer reflections and recommendations. The residents were grateful to continue training close to home, and for maintaining the Tulane program. The consortium successfully provided an administrative and academic framework, logistical support, clinical capacity for the residents to complete the required numbers and types of cases, and integration into preexisting didactic programs. Communications represented a major challenge; the importance of having an up-to-date disaster plan, including provisions for communication using more than one modality or provider, cannot be underestimated. Other challenges included resuming a training program without basic information regarding medical credentials or training status, competing for resources with businesses that had also relocated, maintaining a coordinated decision-making process, and managing the behavioral sequelae after the disaster. Of the original 30 Tulane residents, 23 (77%) relocated to Houston. Seventeen (74%) of those who relocated either graduated or returned with the program to New Orleans. The program has retained its status of full accreditation.

  18. Relocation of the Donner Library collection

    Energy Technology Data Exchange (ETDEWEB)

    LaBrie, Rita Y.

    2005-10-13

    The Donner Library vacated its location from 2nd floor of the Donner Building located on the U.C. Berkeley campus to the 2nd floor of the Building 50 complex at Lawrence Berkeley National Laboratory. The report discusses solutions, options and methods for relocating the Donner Library Collection.

  19. Optimal relocation strategies for spatially mobile consumers

    CERN Document Server

    Iordanov, Iordan

    2007-01-01

    We develop a model of the behaviour of a dynamically optimizing economic agent who makes consumption-saving and spatial relocation decisions. We formulate an existence result for the model, derive the necessary conditions for optimality and study the behaviour of the economic agent, focusing on the case of a wage distribution with a single maximum.

  20. Northeast Pharmaceutical from Relocation Acquires Opportunity

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Northeast Pharmaceutical Group Co., Ltd., an old state-owned company, has met a major development opportunity in its relocation. According to the municipal program made by Shenyang City, Northeast Pharmaceutical Group located in the Tiexi District of Shenyang will move to Shenyang Xihe Development Zone.

  1. Short-distance relocation management approaches: 5 Case from Finland

    OpenAIRE

    Peggie Rothe; Christopher Heywood

    2014-01-01

    Corporate short-distance relocation is a significant event in the course of an organization’s lifetime. While these kinds of relocations happen frequently, they are an infrequent event from the perspective of a single organization. Therefore, few organizations have experience and knowledge on relocation management, which can result in improvised ways of managing the process. The aim of this paper is to describe different short-distance relocation management approaches applied by organizations...

  2. In vitro hydroquinone-induced instauration of histone bivalent mark on human retroelements (LINE-1) in HL60 cells.

    Science.gov (United States)

    Mancini, Monica; Mandruzzato, Martina; Garzia, Alba C; Sahnane, Nora; Magnani, Elena; Macchi, Filippo; Oulad-Abdelghani, Mustapha; Oudet, Pierre; Bollati, Valentina; Fustinoni, Silvia; Furlan, Daniela; Bonapace, Ian M

    2016-12-13

    Benzene is extensively used in industry despite its leukemogenic activity, representing a significant occupational hazard. We investigated if long-term treatment with low-doses hydroquinone (HQ), a benzene metabolite, might be sufficient to alter in vitro the epigenetic signature underlining LINE-1 sequences, a poorly explored step in health risks associated with benzene exposure. In HL-60 cell line, exploring the epigenetic events occurring in chromatin, we found the transient instauration of the distinctive signature combining the repressive H3Lys27 tri-methylation mark and the activating H3Lys4 tri-methylation mark (H3K27me3/H3K4me3), indicating a tendency toward a poised chromatin conformation. These alterations are lost in time after short-term treatments, while the long-term setting, performed using a concentration within the levels of total HQ in peripheral blood of benzene-exposed workers, showed a gradual increase in H3K4me3. We observed the absence of statistically significant variations in DNA methylation and expression levels of LINE-1, despite a decrease in protein levels of UHRF1, DNA methyl-transferases and histone methyl-transferases. In conclusion, in vitro treatment with low-dose HQ determined the instauration of a reversible poised state of chromatin in LINE-1 sequences, suggesting that prolonged exposure could cause persistent epigenetic alterations.

  3. Wages and commuting: quasi-natural experiments' evidence from firms that relocate

    DEFF Research Database (Denmark)

    Mulalic, Ismir; N. Van Ommeren, Jos; Pilegaard, Ninette

    2014-01-01

    We examine individual-level compensating differentials for commuting distance in a quasi-natural experiment setting by examining how wages respond to changes in commuting distance induced by firm relocations. This set-up enables us to test for the relevance of job search frictions within labour...

  4. WAGES AND COMMUTING: QUASI-NATURAL EXPERIMENTS’ EVIDENCE FROM FIRMS THAT RELOCATE

    DEFF Research Database (Denmark)

    Mulalic, Ismir; N. Van Ommeren, Jos; Pilegaard, Ninette

    2014-01-01

    We examine individual-level compensating differentials for commuting distance in a quasi-natural experiment setting by examining how wages respond to changes in commuting distance induced by firm relocations. This set-up enables us to test for the relevance of job search frictions within labour...

  5. 喜疗妥消褪中医罐斑的实验研究%Fading of cupping therapy-induced marks with external application of hirudoid

    Institute of Scientific and Technical Information of China (English)

    安丛丛; 齐彦春; 只利涛; 卢言言

    2012-01-01

    Objective To explore an effective method for shortening retention time of cupping therapy-induced marks. Methods Thirty healthy adults were selected. By using self-controlled study, three Jiaji acupoints on the left back which located near T4 —T6 were given cupping therapy, and were assigned into group A, B, C respectively. Group A did not receive any treatment,group B and C used hirudoid ointment on the marks until they disappeared, with the frequency being once a day in group B and twice a day in group C. Results The score of the marks 24 h after cupping therapy and its reduction, and the time it took for the marks to fade had significant differences among the 3 groups, with the best effect in the group C and the worst in the group A (P<0. 01 for all). Conclusion Hirudoid can effectively shorten fading time of cupping therapy-induced marks, and the frequency of twice a day is recommended.%目的 研究缩短中医拔罐致罐斑存留时间的有效方法.方法 选择正常健康成人30名,采用自身对照研究,在背部左边夹脊穴(第4~6胸椎旁)3个部位拔罐,分别设为A、B、C组.A组拔罐后对罐斑不作任何处理,B、C组拔罐后罐斑涂搽喜疗妥软膏,B组1次/d,C组2次/d,直至罐斑消失.结果 三组罐斑评分在拔罐后24 h及其下降幅度、罐斑消退时间比较,差异有统计学意义,C组最佳,B组次之,A组最差(均P<0.01).结论 喜疗妥能加速罐斑消褪,且每日2次优于每日1次用法.

  6. Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice

    OpenAIRE

    Poole, Jill A.; Wyatt, Todd A; Oldenburg, Peter J.; Elliott, Margaret K.; West, William W.; Sisson, Joseph H.; Von Essen, Susanna G.; Romberger, Debra J.

    2009-01-01

    Organic dust exposure in agricultural environments results in an inflammatory response that attenuates over time, but repetitive exposures can result in chronic respiratory disease. Animal models to study these mechanisms are limited. This study investigated the effects of single vs. repetitive dust-induced airway inflammation in mice by intranasal exposure method. Mice were exposed to swine facility dust extract (DE) or saline once and once daily for 1 and 2 wk. Dust exposure resulted in inc...

  7. Genotoxicity, cytotoxicity, and reactive oxygen species induced by single-walled carbon nanotubes and C(60) fullerenes in the FE1-Mutatrade markMouse lung epithelial cells

    DEFF Research Database (Denmark)

    Jacobsen, Nicklas Raun; Pojana, Giulio; White, Paul;

    2008-01-01

    Viability, cell cycle effects, genotoxicity, reactive oxygen species production, and mutagenicity of C(60) fullerenes (C(60)) and single-walled carbon nanotubes (SWCNT) were assessed in the FE1-Mutatrade markMouse lung epithelial cell line. None of these particles induced cell death within 24 hr...... at doses between 0 and 200 microg/ml or during long-term subculture exposure (576 hr) at 100 microg/ml, as determined by two different assays. However, cell proliferation was slower with SWCNT exposure and a larger fraction of the cells were in the G1 phase. Exposure to carbon black resulted...... by the comet assay. The mutant frequency in the cII gene was unaffected by 576 hr of exposure to either 100 microg/ml C(60) or SWCNT when compared with control incubations, whereas we have previously reported that carbon black and diesel exhaust particles induce mutations using an identical exposure scenario...

  8. Coinfection with the intestinal nematode Heligmosomoides polygyrus markedly reduces hepatic egg-induced immunopathology and proinflammatory cytokines in mouse models of severe schistosomiasis.

    Science.gov (United States)

    Bazzone, Lindsey E; Smith, Patrick M; Rutitzky, Laura I; Shainheit, Mara G; Urban, Joseph F; Setiawan, Tommy; Blum, Arthur M; Weinstock, Joel V; Stadecker, Miguel J

    2008-11-01

    Infection with the trematode helminth Schistosoma mansoni results in a parasite egg-induced, CD4 T-cell-mediated, hepatointestinal granulomatous and fibrosing inflammation that varies greatly in severity, with a higher frequency of milder forms typically occurring in regions where the disease is endemic. One possible explanation for this is that in these regions the degree of inflammation is lessened by widespread concurrent infection with gastrointestinal nematodes. We tested this hypothesis by establishing a murine coinfection model in which mice were infected with the intestinal nematode parasite Heligmosomoides polygyrus prior to infection with S. mansoni. In CBA mice that naturally display a severe form of schistosomiasis, preinfection with H. polygyrus resulted in a marked reduction in schistosome egg-induced hepatic immunopathology, which was associated with significant decreases in the levels of interleukin-17 (IL-17), gamma interferon, tumor necrosis factor alpha, IL-23, IL-6, and IL-1beta and with increases in the levels of IL-4, IL-5, IL-10, and transforming growth factor beta in mesenteric lymph node cells, purified CD4 T cells, and isolated liver granuloma cells. There also were increases in liver Ym1 and forkhead box P3 transcription factor expression. In another model of high-pathology schistosomiasis induced in C57BL/6 mice by immunization with schistosome egg antigens in complete Freund's adjuvant, coinfection with the nematodes also resulted in a marked inhibition of hepatic immunopathology accompanied by similar shifts in cytokine production. These findings demonstrate that intestinal nematodes prevent Th1- and Th17-cell-mediated inflammation by promoting a strong Th2-polarized environment associated with increases in the levels of alternatively activated macrophages and T regulatory cells, which result in significant amelioration of schistosome-induced immunopathology.

  9. Increased plasma citrulline in mice marks diet-induced obesity and may predict the development of the metabolic syndrome.

    Directory of Open Access Journals (Sweden)

    Manuela Sailer

    Full Text Available In humans, plasma amino acid concentrations of branched-chain amino acids (BCAA and aromatic amino acids (AAA increase in states of obesity, insulin resistance and diabetes. We here assessed whether these putative biomarkers can also be identified in two different obesity and diabetic mouse models. C57BL/6 mice with diet-induced obesity (DIO mimic the metabolic impairments of obesity in humans characterized by hyperglycemia, hyperinsulinemia and hepatic triglyceride accumulation. Mice treated with streptozotocin (STZ to induce insulin deficiency were used as a type 1 diabetes model. Plasma amino acid profiling of two high fat (HF feeding trials revealed that citrulline and ornithine concentrations are elevated in obese mice, while systemic arginine bioavailability (ratio of plasma arginine to ornithine + citrulline is reduced. In skeletal muscle, HF feeding induced a reduction of arginine levels while citrulline levels were elevated. However, arginine or citrulline remained unchanged in their key metabolic organs, intestine and kidney. Moreover, the intestinal conversion of labeled arginine to ornithine and citrulline in vitro remained unaffected by HF feeding excluding the intestine as prime site of these alterations. In liver, citrulline is mainly derived from ornithine in the urea cycle and DIO mice displayed reduced hepatic ornithine levels. Since both amino acids share an antiport mechanism for mitochondrial import and export, elevated plasma citrulline may indicate impaired hepatic amino acid handling in DIO mice. In the insulin deficient mice, plasma citrulline and ornithine levels also increased and additionally these animals displayed elevated BCAA and AAA levels like insulin resistant and diabetic patients. Therefore, type 1 diabetic mice but not DIO mice show the "diabetic fingerprint" of plasma amino acid changes observed in humans. Additionally, citrulline may serve as an early indicator of the obesity-dependent metabolic

  10. Increased plasma citrulline in mice marks diet-induced obesity and may predict the development of the metabolic syndrome.

    Science.gov (United States)

    Sailer, Manuela; Dahlhoff, Christoph; Giesbertz, Pieter; Eidens, Mena K; de Wit, Nicole; Rubio-Aliaga, Isabel; Boekschoten, Mark V; Müller, Michael; Daniel, Hannelore

    2013-01-01

    In humans, plasma amino acid concentrations of branched-chain amino acids (BCAA) and aromatic amino acids (AAA) increase in states of obesity, insulin resistance and diabetes. We here assessed whether these putative biomarkers can also be identified in two different obesity and diabetic mouse models. C57BL/6 mice with diet-induced obesity (DIO) mimic the metabolic impairments of obesity in humans characterized by hyperglycemia, hyperinsulinemia and hepatic triglyceride accumulation. Mice treated with streptozotocin (STZ) to induce insulin deficiency were used as a type 1 diabetes model. Plasma amino acid profiling of two high fat (HF) feeding trials revealed that citrulline and ornithine concentrations are elevated in obese mice, while systemic arginine bioavailability (ratio of plasma arginine to ornithine + citrulline) is reduced. In skeletal muscle, HF feeding induced a reduction of arginine levels while citrulline levels were elevated. However, arginine or citrulline remained unchanged in their key metabolic organs, intestine and kidney. Moreover, the intestinal conversion of labeled arginine to ornithine and citrulline in vitro remained unaffected by HF feeding excluding the intestine as prime site of these alterations. In liver, citrulline is mainly derived from ornithine in the urea cycle and DIO mice displayed reduced hepatic ornithine levels. Since both amino acids share an antiport mechanism for mitochondrial import and export, elevated plasma citrulline may indicate impaired hepatic amino acid handling in DIO mice. In the insulin deficient mice, plasma citrulline and ornithine levels also increased and additionally these animals displayed elevated BCAA and AAA levels like insulin resistant and diabetic patients. Therefore, type 1 diabetic mice but not DIO mice show the "diabetic fingerprint" of plasma amino acid changes observed in humans. Additionally, citrulline may serve as an early indicator of the obesity-dependent metabolic impairments.

  11. Marked Acceleration of Atherosclerosis following Lactobacillus casei induced Coronary Arteritis in a Mouse Model of Kawasaki Disease

    Science.gov (United States)

    Chen, Shuang; Lee, Young Ho; Crother, Timothy R.; Fishbein, Michael; Zhang, Wenxuan; Yilmaz, Atilla; Shimada, Kenichi; Schulte, Danica J; Lehman, Thomas J.A.; Shah, Prediman K.; Arditi, Moshe

    2012-01-01

    Objective To investigate if Lactobacillus casei cell wall extract (LCWE)-induced Kawasaki Disease (KD) accelerates atherosclerosis in hypercholesterolemic mice. Method and Resuslts Apoe−/− or Ldlr−/− mice were injected with LCWE (KD mice) or PBS, fed high fat diet for 8 weeks, and atherosclerotic lesions in aortic sinuses (AS), arch (AC) and whole aorta were assessed. KD mice had larger, more complex aortic lesions with abundant collagen, and both extracellular and intracellular lipid and foam cells, compared to lesions in control mice despite similar cholesterol levels. Both Apoe−/− KD and Ldlr−/− KD mice showed dramatic acceleration in atherosclerosis vs. controls, with increases in en face aortic atherosclerosis and plaque size in both the AS and AC plaques. Accelerated atherosclerosis was associated with increased circulating IL-12p40, IFN-γ, TNF-α, and increased macrophage, DC, and T cell recruitment in lesions. Furthermore, daily injections of the IL-1Ra, which inhibits LCWE induced KD vasculitis, prevented the acceleration of atherosclerosis. Conclusions Our results suggest an important pathophysiologic link between coronary arteritis/vasculitis in the KD mouse model and subsequent atherosclerotic acceleration, supporting the concept that a similar relation may also be present in KD patients. These results also suggest that KD in childhood may predispose to accelerated and early atherosclerosis as adults. PMID:22628430

  12. The effects of visual fluorescence marking induced by 5-aminolevulinic acid for endoscopic diagnosis of urinary bladder cancer

    Science.gov (United States)

    Daniltchenko, Dmitri I.; Koenig, Frank; Schnorr, Dietmar; Valdman, Alexander; Al-Shukri, Salman; Loening, Stefan A.

    2003-10-01

    During cystoscopy procedure, fluorescence diagnostics induced by 5-ALA improves visual detection of the bladder cancer. Macroscopic ALA-fluorescence allows visualizing of small flat tumors, carcinoma in situ, true neoplasm margins and dysplasias of the bladder. Following ALA instillation, cystoscopy has been performed under both standard and blue light illumination. Totally, 153 biopsies have been carried out at 53 patients with suspicion of bladder cancer. The results were compared to ALA-fluorescence data. In 13% of the patients, bladder cancer and dysplasia were found out in addition, due to red fluorescence. The sensitivity and specificity of ALA-fluorescence technique aggregated 96% and 52% respectively. The sensitivity and specificity of 5-ALA-fluorescent detection exceeded standard endoscopy under white light on 20%. The new method does not exclude a false positive and a false negative fluorescent luminescence. The ALA-based fluorescence detection system enhances the diagnosis of malignant/dysplastic bladder lesions significantly.

  13. Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: Marked differences between various antipsychotic drugs

    Directory of Open Access Journals (Sweden)

    Vik-Mo Audun O

    2006-10-01

    Full Text Available Abstract Background The etiology of schizophrenia is unknown, but neurodevelopmental disturbances, myelin- and oligodendrocyte abnormalities and synaptic dysfunction have been suggested as pathophysiological factors in this severe psychiatric disorder. Cholesterol is an essential component of myelin and has proved important for synapse formation. Recently, we demonstrated that the antipsychotic drugs clozapine and haloperidol stimulate lipogenic gene expression in cultured glioma cells through activation of the sterol regulatory element-binding protein (SREBP transcription factors. We here compare the action of chlorpromazine, haloperidol, clozapine, olanzapine, risperidone and ziprasidone on SREBP activation and SREBP-controlled gene expression (ACAT2, HMGCR, HMGCS1, FDPS, SC5DL, DHCR7, LDLR, FASN and SCD1 in four CNS-relevant human cell lines. Results There were marked differences in the ability of the antipsychotic drugs to activate the expression of SREBP target genes, with clozapine and chlorpromazine as the most potent stimulators in a context of therapeutically relevant concentrations. Glial-like cells (GaMg glioma and CCF-STTG1 astrocytoma cell lines displayed more pronounced drug-induced SREBP activation compared to the response in HCN2 human cortical neurons and SH-SY5Y neuroblastoma cells, indicating that antipsychotic-induced activation of lipogenesis is most prominent in glial cells. Conclusion Our present data show a marked variation in the ability of different antipsychotics to induce SREBP-controlled transcriptional activation of lipogenesis in cultured human CNS-relevant cells. We propose that this effect could be relevant for the therapeutic efficacy of some antipsychotic drugs.

  14. Marked detergents effects on safranine T-mediated photo-induced electron transfer in cytochrome P-450 1A2.

    Science.gov (United States)

    Nakano, R; Konami, H; Sato, H; Ito, O; Shimizu, T

    1995-10-25

    Cytochrome P-450 accepts electrons from electron transfer proteins to facilitate monooxidation reactions. It is suggested that basic amino acids such as Lys and Arg on the P-450 molecular surface interact with acidic amino acids such as Glu and Asp of the electron transfer protein. Safranine T is a basic compound which mediates electron transfer with illumination. It was found with flash photolysis that an electron from photo-reduced safranine T quickly reaches the heme iron of cytochrome P-450 1A2 (P-450 1A2). The photo-induced reduction kinetics of P-450 1A2 were analyzed by the Runge-Kutta method on the second order assumption. The electron-transfer rate constant from safranine T to P-450 1A2 was 2.1 x 10(6) M-1s-1. The rate constant was remarkably increased up to 3.1 x 10(8) M-1s-1 by adding cholic acid, while that was drastically reduced down to 3.5 x 10(4) M-1s-1 by adding Emulgen 913. The electron-transfer rate of a His163-Glu mutant, which has a 40 mV lower redox potential than that of the wild type, was the same as that of the wild type in the absence of the detergents, although the reduced fraction of the mutant was 30% lower than that of the wild type. The electron-transfer rate of the mutant also changed significantly by adding the detergents in the same way as the wild type. Based on these results, together with optical absorbance and fluorescence data, we discuss the inter- and intramolecular electron-transfer mechanism of P-450 1A2.

  15. 3,4-Methylenedioxymethamphetamine (MDMA) Abuse Markedly Inhibits Acetylcholinesterase Activity and Induces Severe Oxidative Damage and Liperoxidative Damage

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Objective To investigate whether 3,4-methylenedioxymethamphetamine (MDMA) abuse produces another neurotoxicity which may significantly inhibit the acetylcholinesterase activity and result in severe oxidative damage and liperoxidative damage to MDMA abusers. Methods 120 MDMA abusers (MA) and 120 healthy volunteers (HV) were enrolled in an independent sample control design, in which the levels of lipoperoxide (LPO) in plasma and erythrocytes as well as the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and acetylcholinesterase (AChE) in erythrocytes were determined by spectrophotometric methods. Results Compared with the average values of biochemical parameters in the HV group, those of LPO in plasma and erythrocytes in the MA group were significantly increased (P<0.0001), while those of SOD, CAT, GPX and AChE in erythrocytes in the MA group were significantly decreased (P<0.0001). The Pearson product-moment correlation analysis between the values of AChE and biochemical parameters in 120 MDMA abusers showed that significant linear negative correlation was present between the activity of AChE and the levels of LPO in plasma and erythrocytes (P<0.0005-0.0001), while significant linear positive correlation was observed between the activity of AchE and the activities of SOD, CAT and GPX (P<0.0001). The reliability analysis for the above biochemical parameters reflecting oxidative and lipoperoxidative damages in MDMA abusers suggested that the reliability coefficient (alpha) was 0.8124, and that the standardized item alpha was 0.9453. Conclusion The findings in the present study suggest that MDMA abuse can induce another neurotoxicity that significantly inhibits acetylcholinesterase activity and aggravates a series of free radical chain reactions and oxidative stress in the bodies of MDMA abusers, thereby resulting in severe neural, oxidative and lipoperoxidative damages in MDMA abusers.

  16. Marked Differences in C9orf72 Methylation Status and Isoform Expression between C9/ALS Human Embryonic and Induced Pluripotent Stem Cells

    Directory of Open Access Journals (Sweden)

    Yaara Cohen-Hadad

    2016-11-01

    Full Text Available We established two human embryonic stem cell (hESC lines with a GGGGCC expansion in the C9orf72 gene (C9, and compared them with haploidentical and unrelated C9 induced pluripotent stem cells (iPSCs. We found a marked difference in C9 methylation between the cells. hESCs and parental fibroblasts are entirely unmethylated while the iPSCs are hypermethylated. In addition, we show that the expansion alters promoter usage and interferes with the proper splicing of intron 1, eventually leading to the accumulation of repeat-containing mRNA following neural differentiation. These changes are attenuated in C9 iPSCs, presumably owing to hypermethylation. Altogether, this study highlights the importance of neural differentiation in the pathogenesis of disease and points to the potential role of hypermethylation as a neuroprotective mechanism against pathogenic mRNAs, envisaging a milder phenotype in C9 iPSCs.

  17. Chromosome aberrations induced in human lymphocytes by U-235 fission neutrons: I. Irradiation of human blood samples in the "dry cell" of the TRIGA Mark II nuclear reactor.

    Science.gov (United States)

    Fajgelj, A; Lakoski, A; Horvat, D; Remec, I; Skrk, J; Stegnar, P

    1991-11-01

    A set-up for irradiation of biological samples in the TRIGA Mark II research reactor in Ljubljana is described. Threshold activation detectors were used for characterisation of the neutron flux, and the accompanying gamma dose was measured by TLDs. Human peripheral blood samples were irradiated "in vitro" and biological effects evaluated according to the unstable chromosomal aberrations induced. Biological effects of two types of cultivation of irradiated blood samples, the first immediately after irradiation and the second after 96 h storage, were studied. A significant difference in the incidence of chromosomal aberrations between these two types of samples was obtained, while our dose-response curve fitting coefficients alpha 1 = (7.71 +/- 0.09) x 10(-2) Gy-1 (immediate cultivation) and alpha 2 = (11.03 +/- 0.08) x 10(-2) Gy-1 (96 h delayed cultivation) are in both cases lower than could be found in the literature.

  18. Records About Japanese Americans Relocated During World War II

    Data.gov (United States)

    National Archives and Records Administration — This series contains personal descriptive data about Japanese Americans evacuated from the states of Washington, Oregon, and California to ten relocation centers...

  19. Development of Relocation Strategies Regarding Eruption Hazard in Mount Merapi

    Directory of Open Access Journals (Sweden)

    Rosdiana Puji Lestari

    2015-09-01

    Full Text Available The research was conducted to answer a questions: 1 how the relocation of the current strategy was carried out by the government 2 the problems that arise in the relocation which has yet to be resolved, 3 how the good concept of relocation so that these problems can be minimized. The research methodology used in this study combined quantitative and qualitative methods. Qualitative methods are used to explain the empirical facts that exist in each of these conditions in the relocation settlements. SWOT analysis is used to provide an overview of the strengths, weaknesses, opportunities and threats in the relocation of victims of Merapi. Information, facts and issues that arise in the study will be described, explained and analyzed primarily for the impact of residential relocation on social and economic life of the community. Relocation concept of the economic aspects of community empowerment efforts should be made related to community economic recovery after a change in livelihood. In addition, the potential of community mapping needs to be done by the government to be optimized and developed. From the aspect of government settlements seek to transfer ownership of land in the new settlement which may be the property of the citizens so that citizens obtain legal certainty while occupying the new settlement. The social aspects of the development potential of relocating residents and making it as a tourist village, residents need to support that relocation is no longer a newcomer, they have the same rights and obligations with citizens of another.

  20. Management of Relocation in Cognitively Intact Older Adults.

    Science.gov (United States)

    Hertz, Judith E; Koren, Mary Elaine; Rossetti, Jeanette; Tibbits, Kathryn

    2016-11-01

    Relocation, a major life transition that can affect health positively and negatively, is moving from one permanent home to another. Many older adults will relocate at some time during their life. Relocation is also a complex process that requires careful consideration and planning before the move (i.e., pre-location) and adjustment to the new home after the move (i.e., post-relocation). The current article is a summary of content based on a comprehensive evidence-based practice guideline focused on management of relocation in cognitively intact older adults. The guideline was designed to be used across diverse settings by nurses and other providers. Pre-relocation guidelines include assessment for the need for relocation, interventions prior to moving, and outcomes for evaluation of the pre-relocation process. For post-relocation, content focuses on assessment of risks for not adjusting after the move as well as intervention guidelines to promote adjustment and outcomes for evaluation. Implications include advocacy for older adults by using the guideline, disseminating it, and conducting future research. [Journal of Gerontological Nursing, 42(11), 14-23.].

  1. Food Relocalization for Environmental Sustainability in Cumbria

    Directory of Open Access Journals (Sweden)

    Les Levidow

    2011-04-01

    Full Text Available In the past decade, many European farmers have adopted less-intensive production methods replacing external inputs with local resources and farmers’ skills. Some have developed closer relations with consumers, also known as short food-supply chains or agro-food relocalization. Through both these means, farmers can gain more of the value that they have added to food production, as well as greater incentives for more sustainable methods and/or quality products, thus linking environmental and economic sustainability. These systemic changes encounter difficulties indicating two generic needs—for state support measures, and for larger intermediaries to expand local markets. The UK rural county of Cumbria provides a case study for exploring those two needs. Cumbria farmers have developed greater proximity to consumers, as a means to gain their support for organic, territorially branded and/or simply ‘local’ food. This opportunity has been an incentive for practices which reduce transport distances, energy costs and other inputs. Regional authorities have provided various support measures for more closely linking producers with each other and with consumers, together developing a Cumbrian food culture. Going beyond the capacity of individual producers, farmer-led intermediaries have maintained distinctive product identities in larger markets including supermarket chains. Although Cumbria’s agro-food relocalization initiatives remain marginal, they counteract the 1990s trend towards delocalization, while also indicating potential for expansion elsewhere.

  2. Sensor Deployment and Relocation: A Unified Scheme

    Institute of Scientific and Technical Information of China (English)

    Michele Garetto; Marco Gribaudo; Carla-Fabiana Chiasserini; Emilio Leonardi

    2008-01-01

    Sensor networks are envisioned to revolutionize our daily life by ubiquitously monitoring our environment and/or adjusting it to suit our needs. Recent progress in robotics and low-power embedded systems has made it possible to add mobility to small, light, low-cost sensors to be used in teams or swarms. Augmenting static sensor networks with mobile nodes addresses many design challenges that exist in traditional static sensor networks. This paper addresses the problem of topology control in mobile wireless networks. Limitations in communication, computation and energy capabilities push towards the adoption of distributed, energy-efficient solutions to perform self-deployment and relocation of the nodes. We develop a unified, distributed algorithm that has the following features. During deployment, our algorithm yields a regular tessellation of the geographical area with a given node density, called monitoring configuration. Upon the occurrence of a physical phenomenon, network nodes relocate themselves so as to properly sample and control the event, while maintaining the network connectivity. Then, as soon as the event ends, all nodes return to the monitoring configuration. To achieve these goals, we use a virtual force-based strategy which proves to be very effective even when compared to an optimal centralized solution. We assess the performance of our approach in the presence of events with different shapes, and we investigate the transient behavior of our algorithm. This allows us to evaluate the effectiveness and the response time of the proposed solution under various environmental conditions.

  3. Over-expression of TSC-22 (TGF-beta stimulated clone-22) markedly enhances 5-fluorouracil-induced apoptosis in a human salivary gland cancer cell line.

    Science.gov (United States)

    Uchida, D; Kawamata, H; Omotehara, F; Miwa, Y; Hino, S; Begum, N M; Yoshida, H; Sato, M

    2000-06-01

    We have recently isolated TSC-22 (transforming growth factor-beta-stimulated clone-22) cDNA as an anticancer, drug-inducible (with vesnarinone) gene in a human salivary gland cancer cell line, TYS. We have also reported that TSC-22 negatively regulates the growth of TYS cells and that down-regulation of TSC-22 in TYS cells plays a major role in salivary gland tumorigenesis (Nakashiro et al, 1998). In this study, we transfected TYS cells with an expression vector encoding the TSC-22-GFP (green fluorescent protein) fusion protein, and we established TSC-22-GFP-expressing TYS cell clones. Next, we examined (a) the subcellular localization of the fusion protein, (b) the sensitivity of the transfectants to several anticancer drugs (5-fluorouracil, cis-diaminedichloroplatinum, peplomycin), and (c) induction of apoptotic cell death in the transfectants by 5-fluorouracil treatment. The TSC-22-GFP fusion protein was clearly localized to the cytoplasm, but not to the nucleus. Over-expression of the TSC-22-GFP fusion protein did not affect cell growth, but significantly increased the sensitivity of the cells to the anticancer drugs (p way ANOVA). Furthermore, over-expression of the TSC-22-GFP fusion protein markedly enhanced 5-fluorouracil-induced apoptosis. These findings suggest that over-expression of TSC-22-GFP protein in TYS cells enhances the chemosensitivity of the cells via induction of apoptosis.

  4. SOCIO-ECONOMIC AND DYNAMIC RELOCATIONS IN THE WORKPLACE

    Directory of Open Access Journals (Sweden)

    LAVINIA ELISABETA POPP

    2013-12-01

    Full Text Available This paper presents the ways due to which public stakeshares, private or civil society must respond to contemporary social problems being forced to seek new ways to solve public problems. In this context, a growing interest in public institutions to achieve partnerships with the private sector, profit or non-profit begins to manifest, in order to support social development. Social economy sector is growing steadily, the best representation being the non-governmental organizations. These organizations have expanded their number and activities and have started offering a variety of services, thus constituting the key factors that determined their development and reforms of social services in Romania as well. Thus, the policy framework in which private providers of social services operate is evolving permanently, marking new relocations regarding the need for state intervention to regulate the market, the changing relationships and roles. The new reforms have allowed the private sector and the tertiary sector in the social field, to provide the helping and representation framework to vulnerable groups, people with disabilities and certain age groups (children, young and old in a situation of social exclusion. Non-governmental Organizations in Romania have played in the last 20 years an active role in the social services market, supplying the missing services or complementing those provided by the state.

  5. Recurrent uranium relocations in distal turbidites emplaced in pelagic conditions

    Science.gov (United States)

    Colley, S.; Thomson, J.

    1985-11-01

    The sediments of the Madeira Abyssal Plain, east of Great Meteor Seamount, are dominated by distal turbidite deposition. While the turbidites exhibit a wide compositional range (25-80% CaCO 3), individual examples can be correlated over a wide area and are relatively homogenous. Organic C oxidation, by bottom water oxygen, proceeds from the turbidite tops downwards after emplacement in pelagic conditions, and the progress of this oxidation front is marked by a sharp colour contrast in the sediments ( WILSONet al., 1985). In turbidites with C org ≫ 0.5%, redistribution of authigenic U occurs to form a concentration peak (4-9 ppm U), just below the oxidation front or colour change. Several tens μg U/cm 2 may be mobilised, and in all examples studied ≫60% of the remobilised U is relocated into the peak. Following burial by subsequent turbidites, such U concentration peaks are persistent as relict indicators of their extinct oxidation fronts for at least 2 × 10 5 years. In the case of thin turbidites where labile C org is almost exhausted, the U peaks may be located in underlying sedimentary units because of their relationship to the oxidation front. A redox mechanism for U peak formation is suggested from these data rather than a complexation with organic matter.

  6. 47 CFR 0.383 - Emergency Relocation Board, authority delegated.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Emergency Relocation Board, authority delegated... ORGANIZATION Delegations of Authority National Security and Emergency Preparedness Delegations § 0.383 Emergency Relocation Board, authority delegated. (a) During any period in which the Commission is unable to...

  7. Relocation Impacts of a Major Release from SRTC

    Energy Technology Data Exchange (ETDEWEB)

    Blanchard, A.

    1999-05-17

    The relocation impacts of an accidental release, scenario 1-RD-3 , are evaluated for the Savannah River Technology Center. The extent of the area potentially contaminated to a level that would result in doses exceeding the relocation protective action guide is calculated.

  8. Preschoolers' Preparation for Retrieval in Object Relocation Tasks.

    Science.gov (United States)

    Beal, Carole R.; Fleisig, Wayne E.

    The finding that young children do not prepare markers to help themselves relocate objects after a delay may have resulted from children's misunderstanding of the difficulty of unassisted retrieval. This study examined children's ability to recognize that they should prepare markers in two simplified object relocation tasks after they had been…

  9. 24 CFR 583.310 - Displacement, relocation, and acquisition.

    Science.gov (United States)

    2010-04-01

    ... persons. A displaced person (defined in paragraph (f) of this section) must be provided relocation... “displaced person,” or the amount of relocation assistance for which the person is eligible, may file a... to the HUD field office. (f) Definition of displaced person. (1) For purposes of this section,...

  10. Psychometric properties of the index of relocation adjustment.

    Science.gov (United States)

    Bekhet, Abir K; Zauszniewski, Jaclene A

    2014-06-01

    More and more American older adults are relocating to retirement communities, and they experience challenges in adjusting to new surroundings that may increase their depression and mortality. An instrument not previously tested in the United States, the Index of Relocation Adjustment (IRA), may help in early identification of poor relocation adjustment. This study examined the psychometric properties of the IRA using secondary data from a convenience sample of 104 older adults who relocated to 6 retirement communities in Northeast Ohio. Cronbach's alpha was .86. The IRA was correlated with measures of positive cognitions (r = .48, p controllability (r = -.62, p IRA is potentially useful as a screening measure for early detection of poor adjustment among relocated older adults.

  11. Relocating to retirement living: an occupational perspective on successful transitions.

    Science.gov (United States)

    Walker, Emily; McNamara, Beverley

    2013-12-01

    Older adults are increasingly relocating to alternative housing options, such as retirement villages. Relocations can be stressful and these environmental transitions can cause significant disruption to the person-environment and occupational fit, thus influencing health, well-being and quality of life. There is a lack of literature from an occupational therapy perspective in relation to healthy older adults seeking to relocate. This study aimed to identify issues healthy older adults face when relocating to retirement living, what strategies they used during this process, how they maintained a sense of home, and the potential for occupational therapy involvement. Sixteen semi-structured, in-depth interviews were conducted with participants recruited from retirement living facilities across three stages of relocation; 'Decision', 'Early Days', and 'Established'. A grounded theory approach was used to code and analyse the data. Having control over the decisions surrounding relocation, being proactive rather than reactive and preparing sufficiently for the move all contributed to a positive post-location adjustment. Four main themes emerged from the narratives: timing of decision making, new beginnings, continuity, and strategies for change. This study contributes to literature surrounding how older adults occupy and make meaning of the spaces they call home and also enriches literature regarding environmental transitions. Relocation can be a disruptive process and occupational therapists are uniquely placed to facilitate healthy ageing throughout this transition using preventative and community-based occupational therapy. © 2013 Occupational Therapy Australia.

  12. Small-island communities in the Philippines prefer local measures to relocation in response to sea-level rise

    Science.gov (United States)

    Laurice Jamero, Ma.; Onuki, Motoharu; Esteban, Miguel; Billones-Sensano, Xyza Kristina; Tan, Nicholson; Nellas, Angelie; Takagi, Hiroshi; Thao, Nguyen Danh; Valenzuela, Ven Paolo

    2017-08-01

    Most adaptation studies suggest that sea-level rise will lead to relocation as flooding worsens. Here we identified and evaluated potential adaptation strategies for adapting to sea-level rise, based on the experiences of four low-lying island communities in central Philippines that have experienced flooding during normal high tides since a 2013 earthquake that induced land subsidence. Coastal surveys, interviews and household questionnaires showed that island residents generally prefer in situ adaptation strategies rather than relocation to the mainland. These results are unexpected, particularly because a relocation programme has been developed by authorities on the mainland. Direct measurements during a flooding event indicate stilted housing as the most effective type of adaptation strategy. Many households have also raised their floors using coral stones, although this might inadvertently increase their vulnerability to typhoons and storm surges in the long-term.

  13. Industrial relocation and energy consumption: Evidence from China

    Energy Technology Data Exchange (ETDEWEB)

    Zhao Xiaoli, E-mail: email99zxl@vip.sina.co [School of Economics and Business, North China Electric Power University, Beijing 102206 (China); Erb Institute for Global Sustainable Enterprise, University of Michigan, Ann Arbor, MI 48109 (United States); Yin Haitao, E-mail: htyin@sjtu.edu.c [Antai College of Economics and Management, Shanghai Jiao Tong University, Shanghai 200052 (China); Erb Institute for Global Sustainable Enterprise, University of Michigan, Ann Arbor, MI 48109 (United States)

    2011-05-15

    With economic development and the change of industrial structure, industrial relocation is an inevitable trend. In the process of industrial relocation, environmental externality and social cost could occur due to market failure and government failure. Little attention has been paid to this issue. In this paper, we address it with a theoretical analysis and an empirical investigation on the relationship between China's industrial relocation in the early 1990s and energy consumption which is the primary source of CO{sub 2} emission, an environmental externality that causes increasing concerns. The macro-policy analysis suggests that there would be a positive link between China's industrial relocation in the early 1990s and energy saving (and environmental externalities reduction). Using fixed-effect regression model and simulation method, we provide an empirical support to this argument. In order to further reduce environmental externalities and social cost in the process of industrial relocation, we provide policy suggestions as follows: First, strengthen the evaluation of environmental benefits/costs; Second, pay more attention to the coordinated social-economic development; Third, avoid long-lived investment in high-carbon infrastructure in areas with industries moved in; Fourth, address employment issue in the areas with industries moved out. - Research highlights: {yields} Little attention has been paid to the linkage between industrial relocation and environmental externality. {yields} Our macro-policy analysis suggests that there would be a positive link between China's industrial relocation in the early 1990s and energy saving (and environmental externalities reduction). {yields} Using fixed-effect regression model and simulation method, we find a positive link between China's industrial relocation in the early 1990s and energy saving. {yields} Policy suggestions to further reduce environmental externalities and social cost in the process

  14. Relocation impacts of a major release from SRTC

    Energy Technology Data Exchange (ETDEWEB)

    Blanchard, A.; Thompson, E.A.; Thompson, J.M.

    1999-06-01

    The relocation impacts of an accidental release, scenario 1-RD-3 , are evaluated for the Savannah River Technology Center. The extent of the area potentially contaminated to a level that would result in doses exceeding the relocation protective action guide(PAG)is calculated. The maximum calculated distance downwind from the accident at which the relocation PAG is exceeded is also determined. The consequences of the particulate portion of the release are evaluated using the HOTSPOT model and an EXCEL spreadsheet. The consequences of the tritium release are evaluated using UFOTRI.

  15. Mastering Marking Madness

    Science.gov (United States)

    Moore, Brooke

    2009-01-01

    Teachers are smart people, so why does marking reduce them to stressed and soulless messes? Because in their hearts they know that students do not learn from it, and that drives them nuts. Researchers like Lorna Earl and Dylan Wiliam have looked closely at marking systems and have proven what teachers already know deep down: marking student work…

  16. Reconfiguring trade mark law

    DEFF Research Database (Denmark)

    Elsmore, Matthew James

    2013-01-01

    -border setting, with a particular focus on small business and consumers. The article's overall message is to call for a rethink of received wisdom suggesting that trade marks are effective trade-enabling devices. The case is made for reassessing how we think about European trade mark law.......First, this article argues that trade mark law should be approached in a supplementary way, called reconfiguration. Second, the article investigates such a reconfiguration of trade mark law by exploring the interplay of trade marks and service transactions in the Single Market, in the cross...

  17. Parental relocation
    Free movement rights and joint parenting

    Directory of Open Access Journals (Sweden)

    Christina G. Jeppesen de Boer

    2008-06-01

    Full Text Available As joint parental authority increasingly becomes the legal norm applied in situations where the parents do not live together, for example, after divorce or the breakup of a relationship, the settlement of disputes regarding the concrete exercise of parental authority gain relevance. A common dispute concerns the relocation of the resident parent. How do the courts deal with relocation disputes? Is relocation dealt with even-handedly between resident and non-resident parents? Do the same principles apply to relocation inside and outside the jurisdiction? This article compares the approaches taken in Dutch and Danish law, as well as the Principles on Parental Responsibilities drafted by the European Commission on Family Law.

  18. Parental relocation Free movement rights and joint parenting

    Directory of Open Access Journals (Sweden)

    Christina G. Jeppesen de Boer

    2008-06-01

    Full Text Available As joint parental authority increasingly becomes the legal norm applied in situations where the parents do not live together, for example, after divorce or the breakup of a relationship, the settlement of disputes regarding the concrete exercise of parental authority gain relevance. A common dispute concerns the relocation of the resident parent. How do the courts deal with relocation disputes? Is relocation dealt with even-handedly between resident and non-resident parents? Do the same principles apply to relocation inside and outside the jurisdiction? This article compares the approaches taken in Dutch and Danish law, as well as the Principles on Parental Responsibilities drafted by the European Commission on Family Law.

  19. 7 CFR 1944.667 - Relocation and displacement.

    Science.gov (United States)

    2010-01-01

    ... permanent or temporary relocation of displaced persons for units repaired or rehabilitated or for individual... displaced persons. The applicant shall include in its statement of activities, a statement concerning...

  20. Means for Transferring Knowledge in the Relocation of Manufacturing Units

    DEFF Research Database (Denmark)

    Yang, Cheng; Madsen, Erik Skov; Liangsiri, Jirapha

    2009-01-01

    The global spread of production makes companies relocating their manufacturing units to achieve economies of scale, enjoy low-cost labor, or access to new markets. For the relocation, not only equipments, systems and facilities, need to be moved, but also operational knowledge and experience. Based...... on two action research projects, this paper investigates and discusses appropriate means for transfer knowledge when relocating manufacturing units. Different relocation situations are distinguished. Different groups of means including documents or manuals and peer-to-peer training, scenarios on real...... systems, prototypes and games, and emulation, are identified and classified according to their usages. Finally, a framework is summarized to integrate all the elements systematically. This provides strong supports and clear directions to managers and could be used as the guideline and the process model...

  1. Means for Transferring Knowledge in the Relocation of Manufacturing Units

    DEFF Research Database (Denmark)

    Yang, Cheng; Madsen, Erik Skov; Liangsiri, Jirapha

    2009-01-01

    The global spread of production makes companies relocating their manufacturing units to achieve economies of scale, enjoy low-cost labor, or access to new markets. For the relocation, not only equipments, systems and facilities, need to be moved, but also operational knowledge and experience. Based...... on two action research projects, this paper investigates and discusses appropriate means for transfer knowledge when relocating manufacturing units. Different relocation situations are distinguished. Different groups of means including documents or manuals and peer-to-peer training, scenarios on real...... systems, prototypes and games, and emulation, are identified and classified according to their usages. Finally, a framework is summarized to integrate all the elements systematically. This provides strong supports and clear directions to managers and could be used as the guideline and the process model...

  2. When Danish industry relocates – globalisation in an everyday perspective

    Directory of Open Access Journals (Sweden)

    Louise Karlskov Skyggebjerg

    2014-06-01

    Full Text Available When Danish companies move their production abroad, it is often verbalised as a tragedy with focus on the loss of production workplaces in Denmark. This article instead examines what explicitly happens when a company relocates. Based on a study of Royal Copenhagen’s relocation to Thailand as well as a study of a number of Danish companies’ production units in China (Grundfos, RMG Steel, MCI and Fiberline, the focus of this article is on relocation in an everyday perspective with special emphasis on communication, transfer of competencies, company culture and differences in culture.It is concluded – inspired by actor-network theory – that relocation is a complicated process which is not concluded with the opening of a new factory. Many different actor types play significant roles in relation to the manner in which the relocation is carried out in practice; both in the short term during the actual relocation process and in the long term when the relocation has become commonplace. Among the key actor types are human actors such as cultural bridge builders, but not least material actors such as raw materials and buildings as well as immaterial actors such as ‘Danishness’ and ‘the history of the company’. The many actor types indicate, among other, that the dream of relocating becoming a simple process - providing working procedures and products are documented and described to an adequate degree - must be rejected.This article draws inspiration from theories and research about knowledge (transfer, differences in culture, companies’ (historical narratives and recent materiality studies. Methodically, this article is based on two interview based contemporary documentary studies.

  3. Knowledge Transfer and Manufacturing Relocation in International Manufacturing Networks

    DEFF Research Database (Denmark)

    Madsen, Erik Skov

    2014-01-01

    This paper is built on six longitudinal case studies of knowledge transfer in manufacturing relocation. By focusing on tacit and explicit knowledge the paper introduces a model for identification of knowledge in relation to four task situations on the shop floor in a manufacturing environment...... after relocation. Finally the paper discusses how “dispatching capacity” and “absorptive capacity” can improve the process....

  4. Chemotherapy induced neutropenia at 1-month mark is a predictor of overall survival in patients receiving TAS-102 for refractory metastatic colorectal cancer: a cohort study.

    Science.gov (United States)

    Kasi, Pashtoon M; Kotani, Daisuke; Cecchini, Michael; Shitara, Kohei; Ohtsu, Atsushi; Ramanathan, Ramesh K; Hochster, Howard S; Grothey, Axel; Yoshino, Takayuki

    2016-07-13

    TAS-102 (trifluridine and tipiracil hydrochloride; a novel combination oral nucleoside anti-tumor agent) has recently received regulatory approval for patients with refractory metastatic colorectal cancer (mCRC). Internal review of data at a single-institution showed a trend towards better overall survival (OS) for patients who experienced chemotherapy-induced neutropenia at 1-month (CIN-1-month). To explore this finding further, a cohort study was designed based on outcome data from three centers in United States and one from Japan. CIN-1-month after starting TAS-102 was defined by the Common Terminology Criteria for Adverse Events (CTCAE), version 4.03 as a neutrophil count decrease of ≥ grade 2 (absolute neutrophil count < 1500/mm(3)). Patients had confirmed mCRC that was refractory to standard therapies. Patient demographics and clinical characteristics were compared between patients with CIN-1-month (CIN-1-month positive) versus those who did not have CIN-1-month (CIN-1-month negative); with the median progression-free survival (PFS) and OS were calculated using the Kaplan-Meier method, and differences evaluated using the Log-rank test. Our cohort study had a total of 149 patients with data regarding their neutrophil assessment at 1-month mark. Patients who developed ≥ grade 2 CIN-1-month had a both longer PFS (median 3.0 months versus 2.4 months; Log-rank P-value = 0.01), as well as OS (14.0 versus 5.6 months; Log-rank P-value < 0.0001). Only CIN-1-month (adjusted HR: 0.21 (95 % CI: 0.11-0.38) and higher baseline CEA levels (adjusted HR: 2.00 (95 % CI: 1.22-3.35) were noted to be independent predictors of OS. Furthermore, the CIN-1-month was noted to be a statistically significantly predictor of OS over a wide range of cutoffs. Our observations are novel and hypothesis generating. Neutropenia after starting TAS-102 was associated with better prognosis in patients with refractory mCRC. It can be postulated that the dosage of TAS

  5. On denture marking.

    Science.gov (United States)

    Borrman, H I; DiZinno, J A; Wasén, J; René, N

    1999-06-01

    During the last decades in Sweden dentures have been permanently marked with a stainless steel metal band incorporated into the acrylic and containing the patient's birth date, a special number, and "S" for Sweden. The last recommendation issued by the National Board of Health and Welfare states that "the patients shall always be offered denture marking and be informed about the benefit thereof. Denture marking is not permitted if the patient refuses it". Requirements for denture markers have been that they should be biologically inert (when incorporated into the denture), not be expensive, be easy to inscribe, be possible to retrieve after an accident, and survive elevated temperatures for a reasonable time under normal circumstances. Although the frequency of edentulousness has decreased in recent years due to the improvement in oral health there remains a need to address the issue of marking of complete dentures, because there is a large variation in the oral status of populations in different countries. Given that only one marked denture can reveal the identity of a deceased person when all other methods fail to do so, makes it worthwhile. Furthermore, denture marking is important in long-term care facilities. We have investigated the issue of denture marking in Europe and in the United States. The results from the European survey show that denture marking is, to our knowledge regulated by law only in Sweden and Iceland. In the US denture marking is so far mandatory in 21 states while New York State requires dentures to be marked if the patient requests it and several other states impose the obligation to mark dentures on long-term care facilities. Since there is no international consensus regarding the issue of denture marking it is important to address it. A survey from the Nordic countries has shown that if denture marking was in general use, the contribution to the establishment of identity by forensic odontology in cases of fire would increase by about 10

  6. Marking as Judgment

    Science.gov (United States)

    Brooks, Val

    2012-01-01

    An aspect of assessment which has received little attention compared with perennial concerns, such as standards or reliability, is the role of judgment in marking. This paper explores marking as an act of judgment, paying particular attention to the nature of judgment and the processes involved. It brings together studies which have explored…

  7. Marking as Judgment

    Science.gov (United States)

    Brooks, Val

    2012-01-01

    An aspect of assessment which has received little attention compared with perennial concerns, such as standards or reliability, is the role of judgment in marking. This paper explores marking as an act of judgment, paying particular attention to the nature of judgment and the processes involved. It brings together studies which have explored…

  8. High contrast laser marking of alumina

    Energy Technology Data Exchange (ETDEWEB)

    Penide, J. [Applied Physics Department, University of Vigo, EEI, Lagoas-Marcosende, 9, Vigo 36310 (Spain); Quintero, F., E-mail: fquintero@uvigo.es [Applied Physics Department, University of Vigo, EEI, Lagoas-Marcosende, 9, Vigo 36310 (Spain); Riveiro, A. [Applied Physics Department, University of Vigo, EEI, Lagoas-Marcosende, 9, Vigo 36310 (Spain); Fernández, A. [Department of Engineering Design, University of Vigo, Escuela de Ingeniería Industrial, Campus Universitario, Vigo E-36310 (Spain); Val, J. del [Applied Physics Department, University of Vigo, EEI, Lagoas-Marcosende, 9, Vigo 36310 (Spain); Comesaña, R. [Materials Engineering, Applied Mechanics and Construction Department, University of Vigo, EEI, Lagoas-Marcosende, Vigo E-36310 (Spain); Lusquiños, F.; Pou, J. [Applied Physics Department, University of Vigo, EEI, Lagoas-Marcosende, 9, Vigo 36310 (Spain)

    2015-05-01

    Highlights: • Laser marking of alumina using near infrared (NIR) lasers was experimentally analyzed. • Color change produced by NIR lasers is due to thermally induced oxygen vacancies. • Laser marking results obtained using NIR lasers and green laser are compared. • High contrast marks on alumina were achieved. - Abstract: Alumina serves as raw material for a broad range of advanced ceramic products. These elements should usually be identified by some characters or symbols printed directly on them. In this sense, laser marking is an efficient, reliable and widely implemented process in industry. However, laser marking of alumina still leads to poor results since the process is not able to produce a dark mark, yielding bad contrast. In this paper, we present an experimental study on the process of marking alumina by three different lasers working in two wavelengths: 1064 nm (Near-infrared) and 532 nm (visible, green radiation). A colorimetric analysis has been carried out in order to compare the resulting marks and its contrast. The most suitable laser operating conditions were also defined and are reported here. Moreover, the physical process of marking by NIR lasers is discussed in detail. Field Emission Scanning Electron Microscopy, High Resolution Transmission Electron Microscopy and X-ray Photoelectron Spectroscopy were also employed to analyze the results. Finally, we propose an explanation for the differences of the coloration induced under different atmospheres and laser parameters. We concluded that the atmosphere is the key parameter, being the inert one the best choice to produce the darkest marks.

  9. Bite Mark Analysis

    Directory of Open Access Journals (Sweden)

    SK Padmakumar

    2014-07-01

    Full Text Available Bite mark analysis plays an important role in personal identi- fi cation in forensic odontology. They are commonly seen in violent crimes such as sexual assaults, homicides, child abuse, etc. Human bites are common on the face and are usually seen on prominent locations of the face such as the ears, nose and lips. Individual characteristics recorded in the bite marks such as fractures, rotations, attrition, and congenital malformations are helpful in identifying the individual who caused it. We are reporting the case of a 55-year-old lady with bite marks on her left ear, who was allegedly assaulted by the suspect. On the basis of characteristic features of the suspect’s dentition, it was concluded that the bite marks seen on the victim was most probably caused by the suspect.

  10. Mark Raidpere portreefotod Kielis

    Index Scriptorium Estoniae

    1999-01-01

    Kieli Linnagaleriis avatud 2. Ars Baltica fototriennaalil 'Can You Hear Me?' esindab Eestit Mark Raidpere seeriaga 'Portreed 1998'. Näituse Eesti-poolne kuraator Anu Liivak, kataloogiteksti kirjutas Anders Härm. Tuntumaid osalejaid triennaalil Wolfgang Tillmans

  11. Mark 1 Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Mark I Test Facility is a state-of-the-art space environment simulation test chamber for full-scale space systems testing. A $1.5M dollar upgrade in fiscal year...

  12. Mark IVA microprocessor support

    Science.gov (United States)

    Burford, A. L.

    1982-01-01

    The requirements and plans for the maintenance support of microprocessor-based controllers in the Deep Space Network Mark IVA System are discussed. Additional new interfaces and 16-bit processors have introduced problems not present in the Mark III System. The need for continuous training of maintenance personnel to maintain a level of expertise consistent with the sophistication of the required tools is also emphasized.

  13. Marks of Metal Copenhell

    DEFF Research Database (Denmark)

    2015-01-01

    Planchebaseret udendørs udstilling på musikfestivalen Copenhell 18-20/6 2015. En mindre udgave af udstillingen Marks of Metal - Logodesign og visualitet i heavy metal. Udarbejdet i samarbejde med Mediemuseet.......Planchebaseret udendørs udstilling på musikfestivalen Copenhell 18-20/6 2015. En mindre udgave af udstillingen Marks of Metal - Logodesign og visualitet i heavy metal. Udarbejdet i samarbejde med Mediemuseet....

  14. Inter-domain Cooperation in INCENP Promotes Aurora B Relocation from Centromeres to Microtubules

    Directory of Open Access Journals (Sweden)

    Armando van der Horst

    2015-07-01

    Full Text Available The chromosomal passenger complex is essential for error-free chromosome segregation and proper execution of cytokinesis. To coordinate nuclear division with cytoplasmic division, its enzymatic subunit, Aurora B, relocalizes from centromeres in metaphase to the spindle midzone in anaphase. In budding yeast, this requires dephosphorylation of the microtubule-binding (MTB domain of the INCENP analog Sli15. The mechanistic basis for this relocalization in metazoans is incompletely understood. We demonstrate that the putative coiled-coil domain within INCENP drives midzone localization of Aurora B via a direct, electrostatic interaction with microtubules. Furthermore, we provide evidence that the CPC multimerizes via INCENP’s centromere-targeting domain (CEN box, which increases the MTB affinity of INCENP. In (prometaphase, the MTB affinity of INCENP is outcompeted by the affinity of its CEN box for centromeres, while at anaphase onset—when the histone mark H2AT120 is dephosphorylated—INCENP and Aurora B switch from centromere to microtubule localization.

  15. Adsorption capacity of chosen sandy ground with respect to contaminants relocating with groundwater

    Directory of Open Access Journals (Sweden)

    Aniszewski Andrzej

    2017-03-01

    Full Text Available One of the most important problems concerning contaminant transport in the ground is the problem related to the definition of parameters characterizing the adsorption capacity of ground for the chosen contaminants relocating with groundwater. In this paper, for chloride and sulfate indicators relocating in sandy ground, the numerical values of retardation factors (Ra (treated as average values and pore groundwater velocities with adsorption (ux/Ra (in micro-pore ground spaces are taken into consideration. Based on 2D transport equation the maximal dimensionless concentration values (C*max c in the chosen ground cross-sections were calculated. All the presented numerical calculations are related to the unpublished measurement series which was marked in this paper as: October 1982. For this measurement series the calculated concentration values are compared to the measured concentration ones (C*max m given recently to the author of this paper. In final part of this paper the parameters characterizing adsorption capacity (Ra, ux/Ra are also compared to the same parameters calculated for the two earlier measurement series. Such comparison also allowed for the estimation of a gradual in time depletion of adsorption capacity for the chosen sandy ground.

  16. COMPUTER HARDWARE MARKING

    CERN Multimedia

    Groupe de protection des biens

    2000-01-01

    As part of the campaign to protect CERN property and for insurance reasons, all computer hardware belonging to the Organization must be marked with the words 'PROPRIETE CERN'.IT Division has recently introduced a new marking system that is both economical and easy to use. From now on all desktop hardware (PCs, Macintoshes, printers) issued by IT Division with a value equal to or exceeding 500 CHF will be marked using this new system.For equipment that is already installed but not yet marked, including UNIX workstations and X terminals, IT Division's Desktop Support Service offers the following services free of charge:Equipment-marking wherever the Service is called out to perform other work (please submit all work requests to the IT Helpdesk on 78888 or helpdesk@cern.ch; for unavoidable operational reasons, the Desktop Support Service will only respond to marking requests when these coincide with requests for other work such as repairs, system upgrades, etc.);Training of personnel designated by Division Leade...

  17. FACTORS AND ASPECTS OF THE RELOCATION STRATEGIES OF COMPANIES

    Directory of Open Access Journals (Sweden)

    SERGHEI MĂRGULESCU

    2013-05-01

    Full Text Available In the last two decades there have been significant changes in the factors that determine the geographic location or relocation of R & D, production and marketing of all transnational companies. Supply chains have expanded to new areas of the globe and big traditional providers have also expanded their global presence by an increasing trend of co-localization with their main customers. Contract manufacturers have multiplied and strengthened, expanding their geographical distribution. A more obvious trend was that of the geographic dispersion of other global value chain functions such as business services and logistics support functions. Relocation to countries with cheap labor is not always a successful strategy. Therefore the decision to relocate in international geographical area, regardless of the structure formula, offshoring or outsourcing, must be based on a more diverse set of factors.

  18. Factors and aspects of the relocation strategies of companies

    Directory of Open Access Journals (Sweden)

    Serghei Margulescu

    2013-05-01

    Full Text Available In the last two decades there have been significant changes in the factors that determine the geographic location or relocation of R &D, production and marketing of all transnational companies. Supply chains have expanded to new areas of the globe and big traditional providers have also expanded their global presence by an increasing trend of co-localization with their main customers. Contract manufacturers have multiplied and strengthened, expanding their geographical distribution. A more obvious trend was that of the geographic dispersion of other global value chain functions such as business services and logistics support functions. Relocation to countries with cheap labor is not always a successful strategy. Therefore the decision to relocate in international geographical area, regardless of the structure formula, offshoring or outsourcing, must be based on a more diverse set of factors.

  19. Double-difference relocation of earthquakes at Uturuncu volcano, Bolivia, and Interior Alaska

    Science.gov (United States)

    Hutchinson, Laura

    In order to reliably interpret seismic patterns, we must have reliable earthquake locations. To improve our catalog locations, I incorporate cross-correlations into double-difference earthquake relocations to generate high precision relative locations. I perform relocations for two regions, one volcanic and one tectonic. At Uturuncu volcano, I incorporate a wealth of previous studies to present a picture of the processes at play. Seismic, gravity, InSAR, and electromagnetic studies all show that there is a magma body underlying the entire region, and chemical studies suggest that this magma body (the Altiplano-Puna Magma Body, or APMB) is the source of the large ignimbrite eruptions that have occurred in the past. The recent uplift has been modeled as a new batch of magma rising off the APMB, beginning the ascent as a diapir. My relocation results indicate that the seismicity aligns with the top of one of the imaged low velocities zones, which I interpret as a diapir beneath Uturuncu. The earthquakes mark the depth at which the crust is cool enough for brittle deformation. I also perform cross-correlations to determine families of similar events. These families are located around the summit of Uturuncu and display a radial pattern. This suggests that they are due to local volcanic stresses, such as inflation of the volcano, rather than regional stresses. In Interior Alaska, I study a region that is very seismically active, yet has no mapped Holocene faults. There are a series of seismic zones in the area, each comprised of NNE-striking seismic lineations. I perform earthquake relocations on 40 years worth of seismicity in order to refine and interpret fault planes. I additionally examine three earthquake sequences in the Minto Flats Seismic Zone (MFSZ). These earthquakes are large enough (≥M5) to produce an aftershock sequence to map out the rupture plane. I find that two of the three earthquakes occurred on WNW-striking planes, roughly perpendicular to the

  20. Serial Symmetrical Relocation Algorithm for the Equal Sphere Packing Problem

    CERN Document Server

    Huang, WenQi

    2012-01-01

    For dealing with the equal sphere packing problem, we propose a serial symmetrical relocation algorithm, which is effective in terms of the quality of the numerical results. We have densely packed up to 200 equal spheres in spherical container and up to 150 equal spheres in cube container. All results are rigorous because of a fake sphere trick. It was conjectured impossible to pack 68 equal spheres of radius 1 into a sphere of radius 5. The serial symmetrical relocation algorithm has proven wrong this conjecture by finding one such packing.

  1. Augmented marked graphs

    CERN Document Server

    Cheung, King Sing

    2014-01-01

    Petri nets are a formal and theoretically rich model for the modelling and analysis of systems. A subclass of Petri nets, augmented marked graphs possess a structure that is especially desirable for the modelling and analysis of systems with concurrent processes and shared resources.This monograph consists of three parts: Part I provides the conceptual background for readers who have no prior knowledge on Petri nets; Part II elaborates the theory of augmented marked graphs; finally, Part III discusses the application to system integration. The book is suitable as a first self-contained volume

  2. Relocating Subalternity : Scattered Speculations on the Conundrum of a Concept

    NARCIS (Netherlands)

    Mascat, J.; de Jong, S.

    2016-01-01

    This article introduces the special issue ‘Relocating Subalternity: Scattered Speculations on the Conundrum of a Concept’, in which we take Spivak’s particular invocation of (gendered) subalternity and its scholarly reception as a point of departure to confront the ‘foreclosure’ of subalternity.

  3. 24 CFR 576.59 - Relocation and acquisition.

    Science.gov (United States)

    2010-04-01

    ... person is ineligible under 49 CFR 24.2(g)(2); or (D) HUD determines that the person was not displaced as...) Relocation assistance for displaced persons. A displaced person (defined in paragraph (f)(1) of this section...) Definition—(1) Displaced person. (i) The term “displaced person” means a person......

  4. 39 CFR 777.22 - Relocation assistance advisory services.

    Science.gov (United States)

    2010-07-01

    ... persons. (b) Relocation Information. The Postal Service must contact each displaced person to provide an... contact the displaced persons personally, the informational statement must be mailed to the persons... replacement dwellings. (2) For displaced persons eligible for replacement housing payments, explain that...

  5. 24 CFR 42.350 - Relocation assistance for displaced persons.

    Science.gov (United States)

    2010-04-01

    ... described in 49 CFR part 24. A displaced person must be advised of his or her rights under the Fair Housing... of 1974 § 42.350 Relocation assistance for displaced persons. A displaced person may choose to... safety of the person or the public; or (2) The person is displaced from a “lower-income dwelling...

  6. 24 CFR 886.338 - Displacement, relocation, and acquisition.

    Science.gov (United States)

    2010-04-01

    ... regulations at 49 CFR part 24. A “displaced person” shall be advised of his or her rights under the Fair... persons. A “displaced person” (defined in paragraph (g) of this section) must be provided relocation... the requirements described in 49 CFR part 24, subpart B. (e) Appeals. A person who disagrees with...

  7. 24 CFR 882.810 - Displacement, relocation, and acquisition.

    Science.gov (United States)

    2010-04-01

    ... CFR 24.2(g)(2); or (iv) HUD determines that the person was not displaced as a direct result of... section. (c) Relocation assistance for displaced persons. A “displaced person” (defined in paragraph (g... displaced person must be advised of his or her rights under the Fair Housing Act (42 U.S.C. 3601-19) and,...

  8. Relocating Subalternity : Scattered Speculations on the Conundrum of a Concept

    NARCIS (Netherlands)

    Mascat, J.; de Jong, S.

    2016-01-01

    This article introduces the special issue ‘Relocating Subalternity: Scattered Speculations on the Conundrum of a Concept’, in which we take Spivak’s particular invocation of (gendered) subalternity and its scholarly reception as a point of departure to confront the ‘foreclosure’ of subalternity. Whi

  9. Thermal-aware relocation of servers in green data centers

    Institute of Scientific and Technical Information of China (English)

    Muhammad Tayyab CHAUDHRY; T C LING; S A HUSSAIN; Xin-zhu LU

    2015-01-01

    Rise in inlet air temperature increases the corresponding outlet air temperature from the server. As an added effect of rise in inlet air temperature, some active servers may start exhaling intensely hot air to form a hotspot. Increase in hot air tem-perature and occasional hotspots are an added burden on the cooling mechanism and result in energy wastage in data centers. The increase in inlet air temperature may also result in failure of server hardware. Identifying and comparing the thermal sensi-tivity to inlet air temperature for various servers helps in the thermal-aware arrangement and location switching of servers to minimize the cooling energy wastage. The peak outlet temperature among the relocated servers can be lowered and even be homogenized to reduce the cooling load and chances of hotspots. Based upon mutual comparison of inlet temperature sensitivity of heterogeneous servers, this paper presents a proactive approach for thermal-aware relocation of data center servers. The ex-perimental results show that each relocation operation has a cooling energy saving of as much as 2.1 kW·h and lowers the chances of hotspots by over 77%. Thus, the thermal-aware relocation of servers helps in the establishment of green data centers.

  10. Performance Evaluation of Resilience using Service Relocation for GMPLS Networks

    DEFF Research Database (Denmark)

    Wessing, Henrik; Herrmann, Sven; Ruepp, Sarah Renée

    2015-01-01

    path when providing resiliency to cloud services in the network. The control plane of a GMPLSenabled optical network is simulated, thus evaluating the proposed Path Computation Element architecture for service relocation. The results show that for increased offered traffic in the network, the overall...

  11. Firm relocation decisions in The Netherlands : An ordered logit approach

    NARCIS (Netherlands)

    van Dijk, Jouke; Pellenbarg, Piet H.

    2000-01-01

    This article explores the determinants of firm migration in The Netherlands. First, based on the existing literature a theoretical framework is developed. Second, based on aggregate data firm relocation processes in The Netherlands are discussed in terms of numbers, sectoral composition, origins and

  12. Binding of TFIIIC to sine elements controls the relocation of activity-dependent neuronal genes to transcription factories.

    Directory of Open Access Journals (Sweden)

    Luca Crepaldi

    Full Text Available In neurons, the timely and accurate expression of genes in response to synaptic activity relies on the interplay between epigenetic modifications of histones, recruitment of regulatory proteins to chromatin and changes to nuclear structure. To identify genes and regulatory elements responsive to synaptic activation in vivo, we performed a genome-wide ChIPseq analysis of acetylated histone H3 using somatosensory cortex of mice exposed to novel enriched environmental (NEE conditions. We discovered that Short Interspersed Elements (SINEs located distal to promoters of activity-dependent genes became acetylated following exposure to NEE and were bound by the general transcription factor TFIIIC. Importantly, under depolarizing conditions, inducible genes relocated to transcription factories (TFs, and this event was controlled by TFIIIC. Silencing of the TFIIIC subunit Gtf3c5 in non-stimulated neurons induced uncontrolled relocation to TFs and transcription of activity-dependent genes. Remarkably, in cortical neurons, silencing of Gtf3c5 mimicked the effects of chronic depolarization, inducing a dramatic increase of both dendritic length and branching. These findings reveal a novel and essential regulatory function of both SINEs and TFIIIC in mediating gene relocation and transcription. They also suggest that TFIIIC may regulate the rearrangement of nuclear architecture, allowing the coordinated expression of activity-dependent neuronal genes.

  13. Binding of TFIIIC to sine elements controls the relocation of activity-dependent neuronal genes to transcription factories.

    Science.gov (United States)

    Crepaldi, Luca; Policarpi, Cristina; Coatti, Alessandro; Sherlock, William T; Jongbloets, Bart C; Down, Thomas A; Riccio, Antonella

    2013-01-01

    In neurons, the timely and accurate expression of genes in response to synaptic activity relies on the interplay between epigenetic modifications of histones, recruitment of regulatory proteins to chromatin and changes to nuclear structure. To identify genes and regulatory elements responsive to synaptic activation in vivo, we performed a genome-wide ChIPseq analysis of acetylated histone H3 using somatosensory cortex of mice exposed to novel enriched environmental (NEE) conditions. We discovered that Short Interspersed Elements (SINEs) located distal to promoters of activity-dependent genes became acetylated following exposure to NEE and were bound by the general transcription factor TFIIIC. Importantly, under depolarizing conditions, inducible genes relocated to transcription factories (TFs), and this event was controlled by TFIIIC. Silencing of the TFIIIC subunit Gtf3c5 in non-stimulated neurons induced uncontrolled relocation to TFs and transcription of activity-dependent genes. Remarkably, in cortical neurons, silencing of Gtf3c5 mimicked the effects of chronic depolarization, inducing a dramatic increase of both dendritic length and branching. These findings reveal a novel and essential regulatory function of both SINEs and TFIIIC in mediating gene relocation and transcription. They also suggest that TFIIIC may regulate the rearrangement of nuclear architecture, allowing the coordinated expression of activity-dependent neuronal genes.

  14. Fathoming Mark Twain.

    Science.gov (United States)

    Biggar, Joanna

    1988-01-01

    Relates the efforts of completing two collections of the works and papers of Mark Twain. Describes the combined efforts of the University of Iowa and the University of California to publish both a scholarly edition and a reader's edition devoted to Twain. (KO)

  15. Teaching with Mark Dion

    Science.gov (United States)

    Fusaro, Joe

    2011-01-01

    Mark Dion creates sculptures, installations, and interactive environments that sometimes seem contrary to what one expects from visual artists. Remarkable curiosity cabinets and carefully arranged artifacts from specific places and time periods make up a large part of his work. His work does not neatly fit into traditional lessons about elements…

  16. Marked metric measure spaces

    CERN Document Server

    Depperschmidt, Andrej; Pfaffelhuber, Peter

    2011-01-01

    A marked metric measure space (mmm-space) is a triple (X,r,mu), where (X,r) is a complete and separable metric space and mu is a probability measure on XxI for some Polish space I of possible marks. We study the space of all (equivalence classes of) marked metric measure spaces for some fixed I. It arises as state space in the construction of Markov processes which take values in random graphs, e.g. tree-valued dynamics describing randomly evolving genealogical structures in population models. We derive here the topological properties of the space of mmm-spaces needed to study convergence in distribution of random mmm-spaces. Extending the notion of the Gromov-weak topology introduced in (Greven, Pfaffelhuber and Winter, 2009), we define the marked Gromov-weak topology, which turns the set of mmm-spaces into a Polish space. We give a characterization of tightness for families of distributions of random mmm- spaces and identify a convergence determining algebra of functions, called polynomials.

  17. Marked PCP is decidable

    NARCIS (Netherlands)

    Halava, V.; Hirvensalo, M.; de Wolf, R.

    2001-01-01

    We show that the marked version of the Post Correspondence Problem, where the words on a list are required to differ in the first letter, is decidable. On the other hand, we prove that the PCP remains undecidable if we only require the words to differ in the first two letters. Thus we locate the

  18. Acute renal failure induced by markedly decreased appetite secondary to a depressive episode after discontinuation of long-term lithium therapy in an elderly patient with bipolar disorder.

    Science.gov (United States)

    Okada, Akira

    2014-05-16

    Some elderly patients on chronic lithium therapy for bipolar disorder and their doctors may be faced with a therapeutic dilemma over whether or not to continue prescribing/taking lithium given their increased risk of reduced renal function. We present the case of a 78-year-old woman with bipolar disorder who discontinued lithium therapy due to increased risk factors for renal injury. After discontinuation, she experienced markedly decreased appetite secondary to a depressive episode, and developed acute renal failure, which subsequently progressed to a more advanced stage of chronic kidney disease. This case suggests that extreme care must be taken to prevent the recurrence of depression in elderly patients with bipolar disorder who discontinue lithium therapy, even when they had been emotionally stable for a long time while receiving lithium. Medications other than lithium for bipolar disorder may be needed at the time lithium therapy is discontinued. 2014 BMJ Publishing Group Ltd.

  19. Interview with Mark Watson

    Directory of Open Access Journals (Sweden)

    Katy Shaw

    2016-04-01

    Full Text Available Mark Watson is a British comedian and novelist. His five novels to date – 'Bullet Points' (2004, 'A Light-Hearted Look At Murder' (2007, 'Eleven' (2010, 'The Knot' (2012 and 'Hotel Alpha' (2014 – explore human relationships and communities in contemporary society. His latest novel Hotel Alpha tells the story of an extraordinary hotel in London and two mysterious disappearances that raise questions no one seems willing to answer. External to the novel, readers can also discover more about the hotel and its inhabitants in one hundred extra stories that expand the world of the novel and can be found at http://www.hotelalphastories.com. In conversation here with Dr Katy Shaw, Mark offers some reflections on his writing process, the field of contemporary literature, and the vitality of the novel form in the twenty-first century.

  20. Mark Twain on phrenology.

    Science.gov (United States)

    Stone, James L

    2003-12-01

    Mark Twain was a noted 19th century American writer and humorist. He often elaborated upon the personalities of his characters, and his observational skills reflected a strong interest in psychology. Similarly, he found an interest in phrenology, a pseudoscience that purported to characterize personality traits according to elevations or depressions on the head. Twain's style is clearly reflected in the interesting essay he wrote regarding his personal experience with phrenology.

  1. Strain measurement based on laser mark automatic tracking line mark on specimen

    Science.gov (United States)

    Tian, Qiuhong; Sun, Zhengrong; Le, Zhongping; Liu, Yanna; Zhang, Lijian; Xie, Sendong

    2014-12-01

    Conventional video extensometers, using a measurement mark on specimen to obtain material strain, have a problem with deformation of the measurement mark. Therefore, the accurate position of the measurement mark is difficult to evaluate, and measurement accuracy is limited. To solve this problem, a strain measurement method based on a laser mark automatically tracking a line mark on the specimen is proposed. This method is using an undeformed laser mark to replace the line mark to calculate the specimen strain and eliminates the measurement error induced by the deformation of specimen marks. The positions of the laser mark and the line mark are achieved by using digital image processing. Automatic tracking is realized by means of an intelligent motor control. Also, the strain of the specimen is obtained by analyzing the movement trace of the laser mark. A video extensometer experimental setup based on the proposed method is constructed. Two experiments were carried out. The first experiment verified the validity and the repeatability of the method via tensile testing of the specimens of low-carbon steel and cast iron. The second one demonstrated the high measurement accuracy of the method by comparing with a clip-on extensometer.

  2. Telicity marking in Hungarian

    Directory of Open Access Journals (Sweden)

    Éva Kardos

    2016-10-01

    Full Text Available This paper explores the encoding of telicity in Hungarian. While proposing a mereological, scalar semantic analysis, it shows that Hungarian uses a telicity-marking strategy in which it contrasts with English, where telicity is not the direct consequence of an overt marker but arises as a cumulative effect of specific, well-definable properties of various components of verbal predicates including the head verb and its argument(s. A major contribution of the analysis, which mainly addresses telicity marking in the class of non-creation/non-consumption predicates in neutral sentences, lies in the fact that it reveals important cross-linguistic differences with respect to the aspectual role of verbal particles and resultative/locative expressions and the referential properties of telic verbal predicates. As for the former, it is demonstrated that Hungarian verbal particles and resultative/locative expressions mark telicity by directly placing bounds on events by virtue of serving an event maximalizing function, whereas the English counterparts of these elements do not have such direct event-bounding effects. As for the latter, it emerges that in Hungarian quantized reference is a necessary and sufficient condition for telicity in cases where in English it is only sufficient.

  3. Delayed radiation-induced inflammation accompanying a marked carbohydrate antigen 19-9 elevation in a patient with resected pancreatic cancer

    Energy Technology Data Exchange (ETDEWEB)

    Mattes, Malcolm D.; Cardinal, Jon S.; Jacobson, Geraldine M. [West Virginia University School of Medicine, Morgantown (United States)

    2016-06-15

    Although carbohydrate antigen (CA) 19-9 is a useful tumor marker for pancreatic cancer, it can also become elevated from a variety of benign and malignant conditions. Herein we describe an unusual presentation of elevated CA 19-9 in an asymptomatic patient who had previously undergone adjuvant chemotherapy and radiation therapy for resected early stage pancreatic cancer. The rise in CA 19-9 might be due to delayed radiation-induced inflammation related to previous intra-abdominal radiation therapy with or without radiation recall induced by gemcitabine. After treatment with corticosteroids the CA 19-9 level decreased to normal, and the patient has not developed any evidence of recurrent cancer to date.

  4. Staphylococcus epidermidis Biofilm-Released Cells Induce a Prompt and More Marked In vivo Inflammatory-Type Response than Planktonic or Biofilm Cells

    Science.gov (United States)

    França, Angela; Pérez-Cabezas, Begoña; Correia, Alexandra; Pier, Gerald B.; Cerca, Nuno; Vilanova, Manuel

    2016-01-01

    Staphylococcus epidermidis biofilm formation on indwelling medical devices is frequently associated with the development of chronic infections. Nevertheless, it has been suggested that cells released from these biofilms may induce severe acute infections with bacteraemia as one of its major associated clinical manifestations. However, how biofilm-released cells interact with the host remains unclear. Here, using a murine model of hematogenously disseminated infection, we characterized the interaction of cells released from S. epidermidis biofilms with the immune system. Gene expression analysis of mouse splenocytes suggested that biofilm-released cells might be particularly effective at activating inflammatory and antigen presenting cells and inducing cellular apoptosis. Furthermore, biofilm-released cells induced a higher production of pro-inflammatory cytokines, in contrast to mice infected with planktonic cells, even though these had a similar bacterial load in livers and spleens. Overall, these results not only provide insights into the understanding of the role of biofilm-released cells in S. epidermidis biofilm-related infections and pathogenesis, but may also help explain the relapsing character of these infections. PMID:27729907

  5. T-2 toxin induced Salmonella Typhimurium intoxication results in decreased Salmonella numbers in the cecum contents of pigs, despite marked effects on Salmonella-host cell interactions

    Directory of Open Access Journals (Sweden)

    Verbrugghe Elin

    2012-03-01

    Full Text Available Abstract The mycotoxin T-2 toxin and Salmonella Typhimurium infections pose a significant threat to human and animal health. Interactions between both agents may result in a different outcome of the infection. Therefore, the aim of the presented study was to investigate the effects of low and relevant concentrations of T-2 toxin on the course of a Salmonella Typhimurium infection in pigs. We showed that the presence of 15 and 83 μg T-2 toxin per kg feed significantly decreased the amount of Salmonella Typhimurium bacteria present in the cecum contents, and a tendency to a reduced colonization of the jejunum, ileum, cecum, colon and colon contents was noticed. In vitro, proteomic analysis of porcine enterocytes revealed that a very low concentration of T-2 toxin (5 ng/mL affects the protein expression of mitochondrial, endoplasmatic reticulum and cytoskeleton associated proteins, proteins involved in protein synthesis and folding, RNA synthesis, mitogen-activated protein kinase signaling and regulatory processes. Similarly low concentrations (1-100 ng/mL promoted the susceptibility of porcine macrophages and intestinal epithelial cells to Salmonella Typhimurium invasion, in a SPI-1 independent manner. Furthermore, T-2 toxin (1-5 ng/mL promoted the translocation of Salmonella Typhimurium over an intestinal porcine epithelial cell monolayer. Although these findings may seem in favour of Salmonella Typhimurium, microarray analysis showed that T-2 toxin (5 ng/mL causes an intoxication of Salmonella Typhimurium, represented by a reduced motility and a downregulation of metabolic and Salmonella Pathogenicity Island 1 genes. This study demonstrates marked interactions of T-2 toxin with Salmonella Typhimurium pathogenesis, resulting in bacterial intoxication.

  6. Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

    Science.gov (United States)

    Brasacchio, Daniella; Okabe, Jun; Tikellis, Christos; Balcerczyk, Aneta; George, Prince; Baker, Emma K.; Calkin, Anna C.; Brownlee, Michael; Cooper, Mark E.; El-Osta, Assam

    2009-01-01

    OBJECTIVE Results from the Diabetes Control Complications Trial (DCCT) and the subsequent Epidemiology of Diabetes Interventions and Complications (EDIC) Study and more recently from the U.K. Prospective Diabetes Study (UKPDS) have revealed that the deleterious end-organ effects that occurred in both conventional and more aggressively treated subjects continued to operate >5 years after the patients had returned to usual glycemic control and is interpreted as a legacy of past glycemia known as “hyperglycemic memory.” We have hypothesized that transient hyperglycemia mediates persistent gene-activating events attributed to changes in epigenetic information. RESEARCH DESIGN AND METHODS Models of transient hyperglycemia were used to link NFκB-p65 gene expression with H3K4 and H3K9 modifications mediated by the histone methyltransferases (Set7 and SuV39h1) and the lysine-specific demethylase (LSD1) by the immunopurification of soluble NFκB-p65 chromatin. RESULTS The sustained upregulation of the NFκB-p65 gene as a result of ambient or prior hyperglycemia was associated with increased H3K4m1 but not H3K4m2 or H3K4m3. Furthermore, glucose was shown to have other epigenetic effects, including the suppression of H3K9m2 and H3K9m3 methylation on the p65 promoter. Finally, there was increased recruitment of the recently identified histone demethylase LSD1 to the p65 promoter as a result of prior hyperglycemia. CONCLUSIONS These studies indicate that the active transcriptional state of the NFκB-p65 gene is linked with persisting epigenetic marks such as enhanced H3K4 and reduced H3K9 methylation, which appear to occur as a result of effects of the methyl-writing and methyl-erasing histone enzymes. PMID:19208907

  7. Transferring Knowledge in the Relocation of Manufacturing Units

    DEFF Research Database (Denmark)

    Yang, Cheng; Madsen, Erik Skov; Liangsiri, Jirapha

    2010-01-01

    are derived predominantly from a cognitive perspective and normally focus on the organizational level and are rarely linked with outsourcing. Thus, from the perspective of operations management, the purpose of this paper is to explore how to transfer production know-how on the shop-floor level when...... manufacturing units are relocated and indicate which means can be used to support this intra-firm transfer process. Design/methodology/approach - Four cases are identified from research in three Danish companies. Observations and 77 semi-structured interviews have been made over a time period of two years...... in the relocation projects. Together with the framework, a process to help managers implement their knowledge transfer is also proposed. Originality/value - Besides the framework and process, this paper also indicates that absorptive capacity of a production unit depends not only on the level of technical...

  8. Housing Relocation Policy and Violence: A Literature Review.

    Science.gov (United States)

    Casas, Andrea; Duell, Jessica; O'Malley, Teagen; Documet, Patricia; Garland, Richard; Albert, Steven; Fabio, Anthony

    2016-12-01

    This article summarizes and reviews the cross-discipline literature on violent crime in destination neighborhoods postrelocation in order to build a more comprehensive picture of risk factors for violence, as well as how and why housing policies influence risk of violence. High rates of violent crime continue to be a persistent problem in areas of concentrated poverty and public housing. Modern housing programs such as Moving to Opportunity and Housing Opportunities for People Everywhere are popular interventions for reducing the density of low-income people receiving public housing assistance by relocating residents of distressed housing projects. However, evidence suggests that relocated residents may not experience less violence or improved safety in their new communities.

  9. Transferring Knowledge in the Relocation of Manufacturing Units

    DEFF Research Database (Denmark)

    Yang, Cheng; Madsen, Erik Skov; Liangsiri, Jirapha

    2010-01-01

    are derived predominantly from a cognitive perspective and normally focus on the organizational level and are rarely linked with outsourcing. Thus, from the perspective of operations management, the purpose of this paper is to explore how to transfer production know-how on the shop-floor level when...... manufacturing units are relocated and indicate which means can be used to support this intra-firm transfer process. Design/methodology/approach - Four cases are identified from research in three Danish companies. Observations and 77 semi-structured interviews have been made over a time period of two years....... Surveys of documents, questionnaires, and the Delphi method have been used to supplement the research. Findings - Four cases are analyzed from four aspects. By doing so, different relocation situations are identified; different types of transferred knowledge are recognized; and different groups of means...

  10. Transferring Knowledge in the Relocation of Manufacturing Units

    DEFF Research Database (Denmark)

    Yang, Cheng; Madsen, Erik; Liangsiri, Jirapha

    2010-01-01

    transfer are derived predominantly from a cognitive perspective and normally focus on the organizational level. Thus, from the perspective of operations management, this paper aims to explore how to transfer production know-how on the shop floor level when manufacturing units are relocated and the paper...... indicate which means can be used to support this intra-firm transfer process. Design/methodology/approach--Four cases are identified from two action research projects on the basis of observations over one-and-half years and semi-structured interviews with more than 59 people. Other methods, such as surveys...... of documents, questionnaires, and Delphi are also used for supplementary. Findings--Four cases are analyzed from four aspects. By doing so, different relocation situations are identified; different types of transferred knowledge are recognized; different groups of means for knowledge transfer are introduced...

  11. Means for transferring knowledge in the relocation of manufacturing units

    DEFF Research Database (Denmark)

    Madsen, Erik Skov; Yang, Cheng; Liangsiri, Jirapha

    2008-01-01

    Based on case studies and action research, this paper investigates and discusses appropriate means for transfer knowledge when relocating manufacturing units. The cases include relocations both within the country and overseas. A framework for identifying suitable means is developed based...... on the situations which are extracted from the cases. Two parameters are used to classify the situation: the complexity of knowledge, and the environment for transferring the knowledge. Four different groups of means are identified from the case studies; 1) Documents or manuals and peer-to-peer training, 2......) Scenarios on real systems, 3) Prototypes and games, and 4) Emulation. These means are evaluated based on the parameters in the framework and proper means are positioned in the framework. This framework can be used to support learning to develop knowledge in the new manufacturing unit....

  12. Ceremony marking Einstein Year

    CERN Multimedia

    2005-01-01

    Sunday 13th November at 10:00amat Geneva's St. Peter's Cathedral To mark Einstein Year and the importance of the intercultural dialogue of which it forms a part, a religious service will take place on Sunday 13 November at 10 a.m. in St. Peter's Cathedral, to which CERN members and colleagues are warmly welcomed. Pastor Henry Babel, senior minister at the Cathedral, will speak on the theme: 'God in Einstein's Universe'. Diether Blechschmidt will convey a message on behalf of the scientific community.

  13. Ceremony marking Einstein Year

    CERN Multimedia

    2005-01-01

    Sunday 13th November at 10:00amat Geneva's St. Peter's Cathedral To mark Einstein Year and the importance of the intercultural dialogue of which it forms a part, a religious service will take place on Sunday 13 November at 10 a.m. in St. Peter's Cathedral, to which CERN members and colleagues are warmly welcomed. Pastor Henry Babel, senior minister at the Cathedral, will speak on the theme: 'God in Einstein's Universe'. Diether Blechschmidt will convey a message on behalf of the scientific community.

  14. Temperature Discontinuity Caused by Relocation of Meteorological Stations in Taiwan

    Directory of Open Access Journals (Sweden)

    Chih-wen Hung

    2009-01-01

    Full Text Available With global warming upon us, it has be come increasingly important to identify the extent of this warming trend and in doing so be able to rank mean temperature changes in particular seasons and years. This requires a need for homogeneous climate data, which do not reflect individual anomalies in instruments, station locations or local environments (urbanization. Ac curate homogeneous long-term meteorological data helps show how temperature variations have truly occurred in the climate. Many possible factors contribute to artificial abrupt changes or sharp discontinuities in long time series data, such as the impact of station relocation, changes in observational schedules and instrumentation. Homogeneity adjustments of in situ climate data are very important processes for preparing observational data to be used in further analysis and research. Users require a well-documented history of stations to make appropriate homogeneity adjustments because precise historical back ground records of stations can provide researchers with knowledge of when artificial discontinuity has occurred and its causes. With out such de tailed historical data for each meteorological station, abrupt changes are difficult to interpret. Unfortunately, no homogeneity adjustments for temperature records have been con ducted previously in Tai wan, and present available sources of the history of Taiwan's meteorological stations exhibit in consistencies. In this study, information pertaining to station history, especially relocation records, is pro vided. This information is essential for anal y sis of continuous time series data for temperature and climate warming studies. Temperature data from several stations is given in this study to show how artificial discontinuity occurs due to station relocation. Al though there is no homogeneous adjusted climate data provided in this preliminary work, the summarizing of information regarding station relocations should be of assistance

  15. Moving as a gift: relocation in older adulthood.

    Science.gov (United States)

    Perry, Tam E

    2014-12-01

    While discussions of accessibility, mobility and activities of daily living frame relocation studies, in older adulthood, the paper explores the emotional motivation of gift giving as a rationale for moving. This ethnographic study investigates the processes of household disbandment and decision-making of older adults in the Midwestern United States relocating in post-Global Financial Crisis contexts. In this study, relationships are created and sustained through the process of moving, linking older adults (n=81), their kin (n=49), and professionals (n=46) in the Midwestern United States. Using Marcel Mauss' The Gift (1925/1990) as a theoretical lens, relocation in older adulthood is conceptualized as a gift in two ways: to one's partner, and one's kin. Partners may consider gift-giving in terms of the act of moving to appease and honor their partner. Kin who were not moving themselves were also recipients of the gift of moving. These gifts enchain others in relationships of reciprocity. However these gifts, like all gifts, are not without costs or danger, so this paper examines some of the challenges that emerge along with gift-giving.

  16. Marked changes in endogenous antioxidant expression precede vitamin A, C and E-protectable, radiation-induced reductions in small intestinal nutrient transport

    Science.gov (United States)

    Roche, Marjolaine; Kemp, Francis W; Agrawal, Amit; Attanasio, Alicia; Neti, Prasad VSV; Howell, Roger W; Ferraris, Ronaldo P

    2010-01-01

    Rapidly proliferating epithelial crypt cells of the small intestine are susceptible to radiation-induced oxidative stress, yet there is a dearth of data linking this stress to expression of antioxidant enzymes and to alterations of intestinal nutrient absorption. We previously showed that 5 – 14 d after acute γ-irradiation, intestinal sugar absorption decreased without change in antioxidant enzyme expression. In the present study, we measured antioxidant mRNA and protein expression in mouse intestines taken at early times postirradiation. Observed changes in antioxidant expression are characterized by a rapid decrease within 1 h postirradiation, followed by dramatic upregulation within 4 h, and then downregulation a few days later. The cell type and location expressing the greatest changes in levels of the oxidative stress marker 4HNE and in antioxidant enzymes are, respectively, epithelial cells responsible for nutrient absorption and the crypt region comprised mainly of undifferentiated cells. Consumption of a cocktail of antioxidant vitamins A, C and E, before irradiation, prevents reductions in transport of intestinal sugars, amino acids, bile acids and peptides. Ingestion of antioxidants may blunt radiation-induced decreases in nutrient transport, perhaps by reducing acute oxidative stress in crypt cells, thereby allowing the small intestine to retain its absorptive function when those cells migrate to the villus days after the insult. PMID:20970494

  17. Marked differences in drug-induced methemoglobinemia in sheep are not due to RBC glucose-6-phosphate dehydrogenase, reduced glutathione, or methemoglobin reductase activity

    Energy Technology Data Exchange (ETDEWEB)

    Martin, D.G.; Guertler, A.T.; Lagutchik, M.S.; Woodard, C.L.; Leonard, D.A.

    1993-05-13

    Benzocaine is a commonly used topical anesthetic that is structurally similar to current candidates for cyanide prophylaxis. Benzocaine induces profound methemoglobinemia in some sheep but not others. After topical benzocaine administration certain sheep respond to form MHb (elevated MHb 16-50% after a 56-280 mg dose, a 2-10 second spray with benzocine), while other phenotypically similar sheep fail to significantly form MHb (less than a 2% increase from baseline). Deficiencies in Glucose-6-phosphate dehydrogenase (G-6-PD), reduced glutathione (GSH), and MHb reductase increase the susceptibility to methemoglobinemia in man and animals. Sheep are used as a model for G-6-PD deficiency in man, and differences in this enzyme level could cause the variable response seen in these sheep. Similarly, differences in GSH and MHb reductase could be responsible for the observed differences in MHb formation.

  18. Residential relocations among older people over the course of more than ten years

    Science.gov (United States)

    Buurman, Bianca M.; Trentalange, Mark; Nicholson, Nicholas; McGloin, Joanne M.; Gahbauer, Evelyne A.; Allore, Heather G.; Gill, Thomas M.

    2014-01-01

    Objective To describe the rates of residential relocations over the course of 10.5 years and evaluate differences in these relocation rates according to gender and decedent status. Design Prospective, longitudinal study with monthly telephone follow-up for up to 126 months. Setting Greater New Haven, Connecticut. Participants 754 persons, aged 70 years or older, who were initially community-living and nondisabled in their basic activities of daily living. Measurements Residential location was assessed during monthly interviews and included: community, assisted living facility (AL) and nursing home (NH). A residential relocation was defined as a change of residential location for at least one week and included relocations within (e.g. community-community) or between (community-assisted living) locations. We calculated the rates of relocations/1000 patient-months and evaluated differences by gender and decedent status. Results Sixty-six percent of participants had at least one residential relocation (range 0–12). Women had lower rates of relocations from NH to community (rate ratio (RR) 0.59, p=.02); otherwise, there were no gender differences. Decedents had higher rates of relocation from community to AL (RR 1.71, p=0.002), from community to NH (RR 3.64, p<.001), between ALs (RR 3.65, p<.001) and from AL to NH (RR 2.5, p<0.001). In decedents, relocations from community to NH (RR 3.58, p<.001) and from AL to NH (RR 3.3, p<.001) were most often observed in the last year of life. Conclusions A majority of older people relocated at least once during 10.5 years follow-up. Women had lower rates of relocation from NH to community. Decedents were more likely to relocate to a residential location providing a higher level of assistance, compared with non-decedents. Residential relocations were most common in the last year of life. PMID:24794829

  19. An Antigen-Presenting and Apoptosis-Inducing Polymer Microparticle Prolongs Alloskin Graft Survival by Selectively and Markedly Depleting Alloreactive CD8+ T Cells

    Directory of Open Access Journals (Sweden)

    Wei Wang

    2017-06-01

    Full Text Available Selectively depleting the pathogenic T cells is a fundamental strategy for the treatment of allograft rejection and autoimmune disease since it retains the overall immune function of host. The concept of killer artificial antigen-presenting cells (KaAPCs has been developed by co-coupling peptide–major histocompatibility complex (pMHC multimer and anti-Fas monoclonal antibody (mAb onto the polymeric microparticles (MPs to induce the apoptosis of antigen-specific T cells. But little information is available about its in vivo therapeutic potential and mechanism. In this study, polyethylenimine (PEI-coated poly lactic-co-glycolic acid microparticle (PLGA MP was fabricated as a cell-sized scaffold to covalently co-couple H-2Kb-Ig dimer and anti-Fas mAb for the generation of alloantigen-presenting and apoptosis-inducing MPs. Intravenous infusions of the biodegradable KaAPCs prolonged the alloskin graft survival for 43 days in a single MHC-mismatched murine model, depleted the most of H-2Kb-alloreactive CD8+ T cells in peripheral blood, spleen, and alloskin graft in an antigen-specific manner and anti-Fas-dependent fashion. The cell-sized KaAPCs circulated throughout vasculature into liver, kidney, spleen, lymph nodes, lung, and heart, but few ones into local allograft at early stage, with a retention time up to 36 h in vivo. They colocalized with CD8+ T cells in secondary lymphoid organs while few ones contacted with CD4+ T cells, B cells, macrophage, and dendritic cells, or internalized by phagocytes. Importantly, the KaAPC treatment did not significantly impair the native T cell repertoire or non-pathogenic immune cells, did not obviously suppress the overall immune function of host, and did not lead to visible organ toxicity. Our results strongly document the high potential of PLGA MP-based KaAPCs as a novel antigen-specific immunotherapy for allograft rejection and autoimmune disorder. The in vivo mechanism of alloinhibition, tissue

  20. Long-term Temozolomide Treatment Induces Marked Amino Metabolism Modifications and an Increase in TMZ Sensitivity in Hs683 Oligodendroglioma Cells

    Directory of Open Access Journals (Sweden)

    Delphine Lamoral-Theys

    2010-01-01

    Full Text Available Gliomas account for more than 50% of all primary brain tumors. The worst prognosis is associated with gliomas of astrocytic origin, whereas gliomas with an oligodendroglial origin offer higher sensitivity to chemotherapy, especially when oligodendroglioma cells display 1p19q deletions. Temozolomide (TMZ provides therapeutic benefits and is commonly used with radiotherapy in highly malignant astrocytic tumors, including glioblastomas. The actual benefits of TMZ during long-term treatment in oligodendroglioma patients have not yet been clearly defined. In this study, we have investigated the effects of such a long-term TMZ treatment in the unique Hs683 oligodendroglioma model. We have observed increased TMZ sensitivity of Hs683 orthotopic tumors that were previously treated in vitro with months of progressive exposure to increasing TMZ concentrations before being xenografted into the brains of immunocompromised mice. Whole-genome and proteomic analyses have revealed that this increased TMZ sensitivity of Hs683 oligodendroglioma cells previously treated for long periods with TMZ can be explained, at least partly, by a TMZ-induced p38-dependant dormancy state, which in turn resulted in changes in amino acid metabolism balance, in growth delay, and in a decrease in Hs683 oligodendroglioma cell-invasive properties. Thus, long-term TMZ treatment seems beneficial in this Hs683 oligodendroglioma model, which revealed itself unable to develop resistance against TMZ.

  1. A Heuristic Procedure for the Outbound Container Relocation Problem during Export Loading Operations

    Directory of Open Access Journals (Sweden)

    Roberto Guerra-Olivares

    2015-01-01

    Full Text Available During export ship loading operations, it is often necessary to perform relocation movements with containers that interfere with access to the desired container in the ship loading sequence. This paper presents a real-time heuristic procedure for the container relocation problem employing reachstacker vehicles as container handling equipment. The proposed heuristic searches for good relocation coordinates within a set of nearby bays. The heuristic has a parameter that determines how far from the original bay a container may be relocated. The tradeoff between reducing relocation movements and limiting vehicle travel distances is examined and the performance of the heuristic is compared with a common practice in the smaller container terminals in Chile and Mexico. Finally, a mathematical model for the container relocation problem is presented.

  2. Building a new nest: the experience of women relocating to a seniors-designated apartment building.

    Science.gov (United States)

    Dupuis-Blanchard, Suzanne M

    2007-12-01

    Although relocation has been a subject of research for the last 30 years, few studies have described the experience of relocating to congregated housing for the elderly. The purpose of this qualitative grounded theory study was to describe women's experiences of relocating to an apartment building for seniors and the factors that influence relocation. The 11 women interviewed identified the central issue in relocation as re-establishing the self: the physical and psychosocial changes entailed in constructing a supportive and aesthetically pleasing living space while maintaining a sense of well-being. The basic social process that emerged was building a new nest, a non-linear process comprising 3 phases. The findings offer new insights into an aspect of relocation that is rarely explored in nursing research.

  3. Shark Mark Recapture Database (MRDBS)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Shark Mark Recapture Database is a Cooperative Research Program database system used to keep multispecies mark-recapture information in a common format for...

  4. Relocation impacts of an H-Separations coil and tube failure

    Energy Technology Data Exchange (ETDEWEB)

    Blanchard, A.

    2000-03-06

    The relocation impacts of an accidental release, scenario 1-RD-2.35, are evaluated for H-Separations. The extent of the area potentially contaminated to a level that would result in doses exceeding the relocation protective action guide (PAG) is calculated. The maximum calculated distance downwind from the accident at which the relocation PAG is exceeded is also determined. The consequences of the release are evaluated using the HOTSPOT model and an EXCEL spreadsheet.

  5. Relocating labour-intensive manufacturing firms from China to Southeast Asia: a preliminary investigation

    National Research Council Canada - National Science Library

    Yang, Chun

    2016-01-01

    ...). Since 2000, these export-led regions have encountered unprecedented challenges, particularly the rising cost of labour, which have engendered spatial relocation of labour-intensive manufacturing...

  6. Analyses of corium spreading in Mark I containment geometry

    Energy Technology Data Exchange (ETDEWEB)

    Sienicki, J.J.; Chu, C.C.; Farmer, M.T.

    1991-12-31

    An assessment of melt spreading in the Mark I system has been carried out using the MELTSPREAD-1 computer code together with supporting analyses. Application of MELTSPREAD-1 confirms the calculation of shell survival in a wet containment for the most probable melt release conditions from NUREG/CR-5423. According to MELTSPREAD-1, a dry containment also may not be threatened by melt spreading. This reflects the heat losses undergone by the melt in the process of spreading to the shell conservatively neglected in NUREG/CR-5423. However, there exist parameter ranges outside the most probable set where shell failure may be calculated. Accounting for the breakup and quenching of melt relocating through a deep layer of subcooled water also conservatively neglected in NUREG/CR-5423 can reduce the set of parameter variations for which containment failure is calculated in the wet case.

  7. Analyses of corium spreading in Mark I containment geometry

    Energy Technology Data Exchange (ETDEWEB)

    Sienicki, J.J.; Chu, C.C.; Farmer, M.T.

    1991-01-01

    An assessment of melt spreading in the Mark I system has been carried out using the MELTSPREAD-1 computer code together with supporting analyses. Application of MELTSPREAD-1 confirms the calculation of shell survival in a wet containment for the most probable melt release conditions from NUREG/CR-5423. According to MELTSPREAD-1, a dry containment also may not be threatened by melt spreading. This reflects the heat losses undergone by the melt in the process of spreading to the shell conservatively neglected in NUREG/CR-5423. However, there exist parameter ranges outside the most probable set where shell failure may be calculated. Accounting for the breakup and quenching of melt relocating through a deep layer of subcooled water also conservatively neglected in NUREG/CR-5423 can reduce the set of parameter variations for which containment failure is calculated in the wet case.

  8. Focusing patterns of seismicity with relocation and collapsing

    Science.gov (United States)

    Li, Ka Lok; Gudmundsson, Ólafur; Tryggvason, Ari; Bödvarsson, Reynir; Brandsdóttir, Bryndís

    2016-07-01

    Seismicity is generally concentrated on faults or in fault zones of varying, sometimes complex geometry. An earthquake catalog, compiled over time, contains useful information about this geometry, which can help understanding the tectonics of a region. Interpreting the geometrical distribution of events in a catalog is often complicated by the diffuseness of the earthquake locations. Here, we explore a number of strategies to reduce this diffuseness and hence simplify the seismicity pattern of an earthquake catalog. These strategies utilize information about event locations contained in their overall catalog distribution. They apply this distribution as an a priori constraint on relocations of the events, or as an attractor for each individual event in a collapsing scheme, and thereby focus the locations. The latter strategy is not a relocation strategy in a strict sense, although event foci are moved, because the movements are not driven by data misfit. Both strategies simplify the seismicity pattern of the catalog and may help to interpret it. A synthetic example and a real-data example from an aftershock sequence in south west Iceland are presented to demonstrate application of the strategies. Entropy is used to quantify their effect.

  9. Hypocentral Relocations of the 2008 Mt. Carmel, Illinois Aftershock Sequence

    Science.gov (United States)

    Shoemaker, K.; Hamburger, M. W.; Pavlis, G. L.; Horton, S. P.; Withers, M. M.

    2009-12-01

    On April 18, 2008, a moderate sized earthquake (Mw 5.2, hypocentral depth of 16 km) occurred near the Indiana-Illinois state border within 3 km of the Mt. Carmel-New Harmony fault at the northern termination of the Wabash Valley Fault System. A total of 257 aftershocks were recorded over the next month by a fourteen-station temporary network deployed by Indiana University and University of Memphis/Center of Earthquake Research and Information (CERI). The number of recorded aftershocks is greater than aftershocks recorded from previous earthquakes in the WVFS of similar magnitude within the last 50 years. The number and density of local stations allowed the generation of precise hypocentral relocations with the combination of waveform cross-correlation and joint hypocentral techniques. The relocated hypocenters indicate a well-defined near-vertical fault plane striking east-west. The fault orientation is consistent with the focal mechanism of the main shock and nearly orthogonal with respect to the trace of the neighboring Mt. Carmel-New Harmony fault. The interpreted ruptured fault orientation suggests the aftershock sequence occurred on a transfer structure at the fault termination. The structure may be related to the change in deformation styles suggested by the transition from the northeast-trending WVFS to the northwest-trending La Salle anticlinorium.

  10. Dihydralazine induces marked cerebral vasodilation in man

    DEFF Research Database (Denmark)

    Schroeder, T; Sillesen, H

    1987-01-01

    Dihydralazine is widely used for acute control of hypertension. In experimental studies it seems to dilate cerebral resistance vessels and increase intracranial pressure. However, the effect on cerebral blood flow (CBF) in man has been little studied. Measurements of CBF were performed with the i.......v. xenon-133 technique in seven young, normotensive volunteers before and 15, 60 and 180 min after 6.25 mg i.v. dihydralazine, corresponding approximately to 0.1 mg kg-1 body weight. For comparison the CBF reactivity to inhalation of 5% CO2 in air was investigated. Dihydralazine increased CBF throughout...

  11. Mark Kostabi soovib muuta inimesi õnnelikumaks / Kalev Mark Kostabi

    Index Scriptorium Estoniae

    Kostabi, Kalev Mark, 1960-

    2008-01-01

    Kalev Mark Kostabi oma sisekujunduslikest eelistustest, ameeriklaste ja itaallaste kodude sisekujunduse erinevustest, kunstist kui ruumikujunduse ühest osast, oma New Yorgi ja Rooma korterite kujundusest

  12. Mark Kostabi soovib muuta inimesi õnnelikumaks / Kalev Mark Kostabi

    Index Scriptorium Estoniae

    Kostabi, Kalev Mark, 1960-

    2008-01-01

    Kalev Mark Kostabi oma sisekujunduslikest eelistustest, ameeriklaste ja itaallaste kodude sisekujunduse erinevustest, kunstist kui ruumikujunduse ühest osast, oma New Yorgi ja Rooma korterite kujundusest

  13. Modelling cheetah relocation success in southern Africa using an iterative Bayesian network development cycle

    CSIR Research Space (South Africa)

    Johnson, S

    2010-02-01

    Full Text Available Relocation is one of the strategies used by conservationists to deal with problem cheetahs in southern Africa. The success of a relocation event and the factors that influence it within the broader context of long-term viability of wild cheetah...

  14. Relocating a city, challenges and opportunities for the transition of the water infrastructure in Kiruna

    NARCIS (Netherlands)

    Leonhardt, G.; Kuzniecow Bacchin, T.; Mair, M.; Zischg, J.; Ljung, S.; Rogers, B.; Goldkuhl, L.; Gustafsson, A.; Sitzenfrei, R.; Blecken, G.; Ashley, R.; Rauch, W.; van Timmeren, A.; Viklander, M.

    2015-01-01

    The city of Kiruna in Northern Sweden has become known for the need to relocate major parts of the city. Current and future mining activities in the world’s largest underground iron ore mine are the cause of land subsidence that requires relocation of substantial parts of the town including its

  15. The Effects of NAFTA-Driven Relocations on Organizations of the United States and Mexico.

    Science.gov (United States)

    Valentine, Sean

    1997-01-01

    Studies the use of relocation as a method for improving management performance. Describes the impact of manufacturing firms located in Mexico and the impact of relocations, such as the expected attributes of the new location and the use of support services. Discusses implications for employment counselors. (RJM)

  16. The Effects of NAFTA-Driven Relocations on Organizations of the United States and Mexico.

    Science.gov (United States)

    Valentine, Sean

    1997-01-01

    Studies the use of relocation as a method for improving management performance. Describes the impact of manufacturing firms located in Mexico and the impact of relocations, such as the expected attributes of the new location and the use of support services. Discusses implications for employment counselors. (RJM)

  17. Subnuclear relocalization and silencing of a chromosomal region by an ectopic ribosomal DNA repeat

    DEFF Research Database (Denmark)

    Jakociunas, Tadas; Domange Jordö, Marie Elise; Mebarek, Mazhoura Aït;

    2013-01-01

    dimerization, providing a mechanism for the observed relocalization. Replacing the full rDNA repeat with Reb1-binding sites, and using mutants lacking the histone H3K9 methyltransferase Clr4, indicated that the relocalized region was silenced redundantly by heterochromatin and another mechanism, plausibly...

  18. 24 CFR 968.108 - Displacement, relocation, and real property acquisition.

    Science.gov (United States)

    2010-04-01

    ...) of this section. (c) Relocation assistance for displaced persons. A “displaced person” (defined in... “displaced person” shall be advised of his/her rights under the Fair Housing Act (42 U.S.C. 3601-19), and, if... the person qualifies as a “displaced person,” or the amount of the relocation assistance for which...

  19. Relocation Stress, Coping, and Sense of Control among Resettlers Resulting from China's Three Gorges Dam Project

    Science.gov (United States)

    Xi, Juan; Hwang, Sean-Shong

    2011-01-01

    The involuntary relocation of people for development purposes has become prevalent across the world in recent decades. Depression is one of the documented negative outcomes of involuntary relocation among resettlers. Viewing the affected population simply as passive victims, past studies have largely ignored the coping strategies employed by…

  20. The effect of long-term relocation on child and adolescent survivors of Hurricane Katrina.

    Science.gov (United States)

    Hansel, Tonya C; Osofsky, Joy D; Osofsky, Howard J; Friedrich, Patricia

    2013-10-01

    The current study is designed to increase knowledge of the effects of relocation and its association with longer-term psychological symptoms following disaster. Following clinical observations and in discussions held with school officials expressing concerns about relocated students, it was hypothesized that students who relocated to a different city following Hurricane Katrina in 2005 would have more symptoms of posttraumatic stress compared to students who returned to New Orleans. The effect of Hurricane Katrina relocation was assessed on a sample of child and adolescent survivors in 5th through 12th grades (N = 795). Students with Orleans Parish zip codes prior to Hurricane Katrina were categorized into relocation groupings: (a) relocated to Baton Rouge, (b) returned to prior zip code, and (c) moved to a different zip code within Orleans Parish. Overall results revealed more trauma symptoms for relocated students. Results also revealed that younger relocated students had fewer symptoms compared to older students. The opposite was found for students who returned to their same zip code, with older students having fewer symptoms. This study supports the need for school-based services not only in disaster areas, but also in schools where survivors tend to migrate. Copyright © 2013 International Society for Traumatic Stress Studies.

  1. Policy interventions and grassroots initiatives: Mismatches in a relocation project in Chennai, India

    NARCIS (Netherlands)

    M. van Eerd (Maartje)

    2008-01-01

    textabstractThis article is based on research that took place between 1998 and 2002 in a relocation project in Southern Chennai, India. About 2,640 poor urban households were relocated from the city centre to the project location on the outskirts of the city in the early 1990s. The objectives of the

  2. 76 FR 32340 - Federal Travel Regulation; Temporary Duty (TDY) Travel Allowances (Taxes); Relocation Allowances...

    Science.gov (United States)

    2011-06-06

    ... Duty (TDY) Travel Allowances (Taxes); Relocation Allowances (Taxes) AGENCY: Office of Governmentwide... extended temporary duty (TDY) benefits to correct errors and to align that process with the proposed... incurred by employees as a result of relocation and to reimburse ``all'' of the taxes imposed on any...

  3. Improving Marking Quality through a Taxonomy of Mark Schemes

    Science.gov (United States)

    Ahmed, Ayesha; Pollitt, Alastair

    2011-01-01

    At the heart of most assessments lies a set of questions, and those who write them must achieve "two" things. Not only must they ensure that each question elicits the kind of performance that shows how "good" pupils are at the subject, but they must also ensure that each mark scheme gives more marks to those who are…

  4. Molecular basis for prey relocation in viperid snakes

    Science.gov (United States)

    2013-01-01

    Background Vertebrate predators use a broad arsenal of behaviors and weaponry for overcoming fractious and potentially dangerous prey. A unique array of predatory strategies occur among snakes, ranging from mechanical modes of constriction and jaw-holding in non-venomous snakes, to a chemical means, venom, for quickly dispatching prey. However, even among venomous snakes, different prey handling strategies are utilized, varying from the strike-and-hold behaviors exhibited by highly toxic elapid snakes to the rapid strike-and-release envenomation seen in viperid snakes. For vipers, this mode of envenomation represents a minimal risk predatory strategy by permitting little contact with or retaliation from prey, but it adds the additional task of relocating envenomated prey which has wandered from the attack site. This task is further confounded by trails of other unstruck conspecific or heterospecific prey. Despite decades of behavioral study, researchers still do not know the molecular mechanism which allows for prey relocation. Results During behavioral discrimination trials (vomeronasal responsiveness) to euthanized mice injected with size-fractionated venom, Crotalus atrox responded significantly to only one protein peak. Assays for enzymes common in rattlesnake venoms, such as exonuclease, L-amino acid oxidase, metalloproteinase, thrombin-like and kallikrein-like serine proteases and phospholipase A2, showed that vomeronasal responsiveness was not dependent on enzymatic activity. Using mass spectrometry and N-terminal sequencing, we identified the proteins responsible for envenomated prey discrimination as the non-enzymatic disintegrins crotatroxin 1 and 2. Our results demonstrate a novel and critical biological role for venom disintegrins far beyond their well-established role in disruption of cell-cell and cell-extracellular matrix interactions. Conclusions These findings reveal the evolutionary significance of free disintegrins in venoms as the molecular

  5. Hypocentric Relocations Aided by Virtual Receivers Constructed via Seismic Interferometry?

    Science.gov (United States)

    Horowitz, F. G.

    2013-12-01

    The 3D elastic wave propagation program (WPP; Petersson & Sjogreen, B 2011) has been used to investigate whether the technique of Curtis et al. (2009) can be used to improve hypocentric relocations by employing virtual receivers near a cloud of microearthquakes. The virtual receiver technique can be loosely described as the "dual" of the ambient noise technique from seismic interferometry -- replacing noise sources on the boundary of a region of interest with physical receivers. Seismograms from events in the interior of the region of interest can be cross-correlated and integrated over all boundary receivers to estimate a seismogram from one of the interior events as if it were recorded at the location of another interior event. Unlike ambient noise interferometry, where raypaths from all directions impinge on the region of interest, Virtual Receivers raypath directions are constrained by the location of the physical receiver array. Hence, approximating the surface integral plays a large role in the practical success of the technique. Fortunately, stationary-phase arguments suggest that only a few physical receivers nearby the interior-source to virtual-receiver ray direction suffice to reconstruct the seismogram (as described in Curtis et al., 2009). Arrival time error statistics supporting this conclusion from WPP simulations will be shown at the meeting. Additionally, relocations of perturbed synthetic hypocenters using virtual receiver arrivals are anticipated by the time of the meeting. References: Curtis, A., Nicolson, H., Halliday, D., Trampert, J., & Baptie, B. (2009). Virtual seismometers in the subsurface of the earth from seismic interferometry. Nature Geoscience, 2 (10), 700-704. Petersson, N. A., & Sjogreen, B. (2011). User's guide to WPP version 2.1.5. Lawrence Livermore National Laboratory.

  6. Relocations of Earthquakes (1899 1917) in South-Central Alaska

    Science.gov (United States)

    Doser, Diane I.

    2006-08-01

    I have relocated 18 earthquakes occurring in the south-central Alaska region between 1899 and 1917 using a bootstrap relocation technique. Locations of events within the Yakutat region suggest that the 1899 sequence began on 4 September with a MS = 7.9 event within the area of the Pamplona fault zone/western Transition fault zone, rupturing the western portion of the North American/Pacific plate interface. A MS = 7.4 event on 10 September appears to have ruptured the offshore portion of the plate interface to the east of the 4 September event. This was followed by a MS = 8.0 event that likely ruptured the onshore and down-dip portion of the plate interface. A MS = 7.0 event in 1908 may have ruptured a small portion of the plate interface between the 4 September and 10 September events. Events occurring between 1911 and 1916 in the Prince William Sound region appear to be slab events occurring in similar locations to more recent seismicity. Within the Kodiak region the 1900 earthquake of MS = 7.7 has a location consistent with the rupture of the Kodiak asperity which also ruptured during the 1964 great Alaska earthquake. Other large magnitude Kodiak events appear to be associated with regions of recent seismicity, including the Karluk Lake area of southwestern Kodiak Island and the Albatross Basin located offshore southeast of Kodiak Island. Space-time seismicity patterns since 1899 indicate that magnitude 6 to7 events have occurred with regularity in the Kodiak Island region; that there has been a lack of magnitude ≥ 6 events in the Prince William Sound region since 1964, and that the Yakutat region has remained notably quiescent at the magnitude ≥ 6 level.

  7. Mark-specific hazard ratio model with missing multivariate marks.

    Science.gov (United States)

    Juraska, Michal; Gilbert, Peter B

    2016-10-01

    An objective of randomized placebo-controlled preventive HIV vaccine efficacy (VE) trials is to assess the relationship between vaccine effects to prevent HIV acquisition and continuous genetic distances of the exposing HIVs to multiple HIV strains represented in the vaccine. The set of genetic distances, only observed in failures, is collectively termed the 'mark.' The objective has motivated a recent study of a multivariate mark-specific hazard ratio model in the competing risks failure time analysis framework. Marks of interest, however, are commonly subject to substantial missingness, largely due to rapid post-acquisition viral evolution. In this article, we investigate the mark-specific hazard ratio model with missing multivariate marks and develop two inferential procedures based on (i) inverse probability weighting (IPW) of the complete cases, and (ii) augmentation of the IPW estimating functions by leveraging auxiliary data predictive of the mark. Asymptotic properties and finite-sample performance of the inferential procedures are presented. This research also provides general inferential methods for semiparametric density ratio/biased sampling models with missing data. We apply the developed procedures to data from the HVTN 502 'Step' HIV VE trial.

  8. Divided parents, shared children Conflicting approaches to relocation disputes in the USA

    Directory of Open Access Journals (Sweden)

    Theresa Glennon

    2008-06-01

    Full Text Available Custody relocation disputes pose intractable dilemmas for courts in a highly mobile society. The custodial parent, most often a woman, seeks self-determination, freedom of movement and a continued custodial relationship with the child. The non-custodial parent seeks to preserve a geographically close relationship with the child. Courts must identify the best interests of the children amidst these multiple and conflicting interests. They make decisions that may determine the course of custodial parents’ lives, affecting remarriage, employment, education, and proximity to family. A narrow doctrinal focus on children’s best interests ignores these key aspects of relocation disputes. This article examines the varied legislative and judicial approaches to relocation disputes in the US and proposed principles for resolution of these disputes. It reviews scholarship analyzing relocation disputes from a wide range of perspectives, including: conflicting social science research; competing ideologies of the post-divorce family; alternative dispute resolution; parents’ constitutional rights; domestic violence victims; and proposals to eliminate geographic presumptions and remedy the economic effect of restraints on relocation. Relocation doctrine in the US should be realigned to address these complex perspectives. States should also assist post-divorce families to support children through the common experience of relocation.

  9. Teleseismic Double-Difference Earthquake Hypocenter Relocation in the Indonesian Region

    Science.gov (United States)

    Nugraha, A. D.; Shiddiqi, H. A.; Widiyantoro, S.; Ramdhan, M.; Wandono, W.; Sutiyono, S.; Handayani, T.

    2014-12-01

    Accuracy of hypocenter location is a crucial obstacle for seismicity study. Therefore, it is important to obtain accurate earthquake location using an adequate relocation method. We have relocated nearly 30,000 earthquakes (with magnitude greater than 2.0) compiled by BMKG from April 2009 to June 2014 around the Indonesian region using teleseismic double-difference relocation algorithm. We used arrival time data from local, regional and teleseismic stations. For the inversion procedure, we have applied 1-D and 3-D seismic velocity models to determine earthquake hypocenter location. Our relocation results show that the travel-time RMS errors were greatly reduced. The hypocenter locations distribution shows significantly improved locations after the relocation. The relocated hypocenters also exhibit improvement in hypocenter depths particularly for shallow earthquakes. Overall, our relocation results were well correlated with tectonic features in this region, e.g. major subduction zones beneath Sumatra, Java, Bali, Banda, Sulawesi and Molluca and inland fault zones such as the Sumatra faut zone. These results will provide better information for updating seismic hazard maps and further advanced studies in the Indonesian region.

  10. Divided parents, shared children
    Conflicting approaches to relocation disputes in the USA

    Directory of Open Access Journals (Sweden)

    Theresa Glennon

    2008-06-01

    Full Text Available Custody relocation disputes pose intractable dilemmas for courts in a highly mobile society. The custodial parent, most often a woman, seeks self-determination, freedom of movement and a continued custodial relationship with the child. The non-custodial parent seeks to preserve a geographically close relationship with the child. Courts must identify the best interests of the children amidst these multiple and conflicting interests. They make decisions that may determine the course of custodial parents’ lives, affecting remarriage, employment, education, and proximity to family. A narrow doctrinal focus on children’s best interests ignores these key aspects of relocation disputes. This article examines the varied legislative and judicial approaches to relocation disputes in the US and proposed principles for resolution of these disputes. It reviews scholarship analyzing relocation disputes from a wide range of perspectives, including: conflicting social science research; competing ideologies of the post-divorce family; alternative dispute resolution; parents’ constitutional rights; domestic violence victims; and proposals to eliminate geographic presumptions and remedy the economic effect of restraints on relocation. Relocation doctrine in the US should be realigned to address these complex perspectives. States should also assist post-divorce families to support children through the common experience of relocation.

  11. Surgical skin-marking techniques.

    Science.gov (United States)

    Granick, M S; Heckler, F R; Jones, E W

    1987-04-01

    Surgical skin-marking inks and dyes are in everyday use for designing and planning incisions in plastic and reconstructive surgery. We have traced the historical development of surgical skin-marking techniques from ancient times to the present. The biochemical characteristics of the commonly used marking agents are discussed. A three-part experiment utilizing a pig model was carried out to test the tissue inflammatory response to the various dyes and inks when used intradermally as tattoos, the persistence of such tattoos, and the ease of skin erasure for each of eight stains. Methylene blue and gentian violet are recommended as the best all-purpose marking agents. The use of proprietary inks is discouraged.

  12. Eesti vajab riigiarhitekti / Mark Soosaar

    Index Scriptorium Estoniae

    Soosaar, Mark, 1946-

    2006-01-01

    Linnade tekkimisest Eestis, linnaehitusest ja linnaplaneerimisest. Pärnu muinsuskaitsealast ja uute korruselamute ehitamisest. Arhitektuuriameti loomise ja riigiarhitekti ametikoha vajalikkusest. Kommenteerivad Ülar Mark, Triin Ojari, Harry Liivrand, Karin Paulus

  13. Relocation of long-period (LP) seismic events reveals en echelon fractures in the upper edifice of Turrialba volcano, Costa Rica

    Science.gov (United States)

    Zecevic, Megan; De Barros, Louis; Eyre, Thomas S.; Lokmer, Ivan; Bean, Christopher J.

    2016-10-01

    Swarms of long-period (LP) events were recorded on Turrialba volcano, Costa Rica, during a seismic field experiment in 2009. Families of LP events were previously identified and located using a joint inversion for source location and mechanism; however, the spatial resolution of the obtained locations was not sufficient for imaging the structures on which they occur. Using a waveform similarity-based location method, we take advantage of the joint location-mechanism inversion by relocating events around the obtained familial location. The location method is successfully tested on a synthetic data set and is then applied to the Turrialba LP data set. The relocated events are jointly interpreted with their source mechanisms and reveal an en echelon structure within the upper edifice of the volcano. This can be interpreted as a response of a shearing band with high fluid pressure inducing tensile fractures at unconsolidated rock layer interfaces within the upper edifice of the volcano.

  14. Lane marking aided vehicle localization

    OpenAIRE

    2013-01-01

    International audience; A localization system that exploits L1-GPS estimates, vehicle data, and features from a video camera as well as lane markings embedded in digital navigation maps is presented. A sensitivity analysis of the detected lane markings is proposed in order to quantify both the lateral and longitudinal errors caused by 2D-world hypothesis violation. From this, a camera observation model for vehicle localization is proposed. The paper presents also a method to build a map of th...

  15. Civilsamfundets ABC: M for Marked

    DEFF Research Database (Denmark)

    Lund, Anker Brink; Meyer, Gitte

    2016-01-01

    Bogstaveligt talt: Hvad er civilsamfundet? Anker Brink Lund og Gitte Meyer fra CBS Center for Civil Society Studies gennemgår civilsamfundet bogstav for bogstav. Vi er nået til M for Marked.......Bogstaveligt talt: Hvad er civilsamfundet? Anker Brink Lund og Gitte Meyer fra CBS Center for Civil Society Studies gennemgår civilsamfundet bogstav for bogstav. Vi er nået til M for Marked....

  16. Modeling and Simulation of Relocation of a Production in SIMPRO-Q Web Based Educational Environment

    Directory of Open Access Journals (Sweden)

    Lubomir Lengyel

    2012-02-01

    Full Text Available The aim of this paper is to show the how to get new knowledge and skills through solving production relocation situations in a continuously changing global environment. The used methods model and simulate the related risks, using web based learning environment of Quality Management Role Play Simulation (SIMPRO-Q. The presented methods are applicable also in engineering education. During simulations, the role-players make both quantitative and qualitative decisions regarding management of critical situations during production relocation. Experiences from relocation production project in industry are discussed at the end of the paper.

  17. Inflectional marking in Hungarian aphasics.

    Science.gov (United States)

    MacWhinney, B; Osmán-Sági, J

    1991-08-01

    How do aphasics deal with the rich inflectional marking available in agglutinative languages like Hungarian? For the Hungarian noun alone, aphasics have to deal with over 15 basic case markings and dozens of possible combinations of these basic markings. Using the picture description task of MacWhinney and Bates (1978), this study examined the use of inflectional markings in nine Broca's and five Wernicke's aphasic speakers of Hungarian. The analysis focused on subject, direct object, indirect object, and locative nominal arguments. Compared to normals, both groups had a much higher rate of omission of all argument types. Subject ellipsis was particularly strong, as it is in normal Hungarian. There was a tendency for Broca's to omit the indirect object and for Wernicke's to omit the direct object. Across argument types, Wernicke's had a much higher level of pronoun usage than did Broca's. Broca's also showed a very high level of article omission. Compared to similar data reported by Slobin (this issue) for Turkish, the Hungarian aphasics showed an elevated level of omission of case markings. Addition errors were quite rare, but there were 14 substitutions of one case marking for another. These errors all involved the substitution of some close semantic competitor. There were no errors in the basic rules for vowel harmony or morpheme order. Overall the results paint a picture of a group of individuals whose grammatical abilities are damaged and noisy, but still largely functional. Neither the view of Broca's as agrammatic nor the view of Wernicke's as paragrammatic was strongly supported.

  18. Identification marking by means of laser peening

    Science.gov (United States)

    Hackel, Lloyd A.; Dane, C. Brent; Harris, Fritz

    2002-01-01

    The invention is a method and apparatus for marking components by inducing a shock wave on the surface that results in an indented (strained) layer and a residual compressive stress in the surface layer. One embodiment of the laser peenmarking system rapidly imprints, with single laser pulses, a complete identification code or three-dimensional pattern and leaves the surface in a state of deep residual compressive stress. A state of compressive stress in parts made of metal or other materials is highly desirable to make them resistant to fatigue failure and stress corrosion cracking. This process employs a laser peening system and beam spatial modulation hardware or imaging technology that can be setup to impress full three dimensional patterns into metal surfaces at the pulse rate of the laser, a rate that is at least an order of magnitude faster than competing marking technologies.

  19. Project proposal : control of crested wheatgrass by relocation of black-tailed prairie dogs

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Proposal for research at the Rocky Mountain Arsenal to examine experimental means of controlling crested wheatgrass while establishing relocated prairie dog colonies...

  20. Prediction of changes in groundwater dynamics caused by relocation of river embankments

    Directory of Open Access Journals (Sweden)

    U. Mohrlok

    2003-01-01

    Full Text Available Ecosystems in river valleys are affected mainly by the hydraulic conditions in wetlands including groundwater dynamics. The quantitative prediction of changes in groundwater dynamics caused by river embankment relocation requires numerical modelling using a physically-based approach. Groundwater recharge from the intermittently flooded river plains was determined by a leakage approach considering soil hydraulic properties. For the study area in the Elbe river valley north of Magdeburg, Germany, a calibrated groundwater flow model was established and the groundwater dynamics for the present situation as well as for the case of embankment relocation were simulated over a 14-year time period. Changes in groundwater depth derived from simulated groundwater levels occurred only during flood periods. By analysing the spatial distributions of changes in statistical parameters, those areas with significant impact on the ecosystems by embankment relocation can be determined. Keywords: groundwater dynamics,groundwater recharge, flood plains, soil hydraulic properties, numerical modelling, river embankment relocation

  1. Study of seismicity around Toba area based on relocation hypocenter result from BMKG catalogue

    Energy Technology Data Exchange (ETDEWEB)

    Ramdhan, Mohamad [Indonesia' s Agency for Meteorology, Climatology and Geophysics (BMKG) Jl. Angkasa 1 No. 2 Kemayoran, Jakarta Pusat, 10720 (Indonesia); Nugraha, Andri Dian [Global Geophysics Research Group, Faculty of Mining and Petroleum Engineering, Institute of Technology Bandung, Indonesia, Jl. Ganesa 10, Bandung, 40132 (Indonesia)

    2013-09-09

    Toba area has complex tectonic setting attracting many earth scientists to study and understand tectonic and geological process or setting. The area is affected by oblique subduction zone, Renun Sumatran fault sub segment and some volcanoes that are near it. The earthquake catalogue provided by BMKG from April, 2009 to December, 2011 must be relocated firstly to get the precise hypocenter. We used catalogue data of P and S phase or P phase only and double-difference method to relocate the earthquakes. The results show hypocenter position enhancement that can be interpreted tectonically. The earthquakes after relocation relating to the Sumatran fault, subduction zone, volcanoes and seismic activities beneath Toba caldera can be mapped clearly. The relocated hypocenters in this study are very important to provide information for seismic hazard assessment and disaster mitigation study.

  2. Study of seismicity around Toba area based on relocation hypocenter result from BMKG catalogue

    Science.gov (United States)

    Ramdhan, Mohamad; Nugraha, Andri Dian

    2013-09-01

    Toba area has complex tectonic setting attracting many earth scientists to study and understand tectonic and geological process or setting. The area is affected by oblique subduction zone, Renun Sumatran fault sub segment and some volcanoes that are near it. The earthquake catalogue provided by BMKG from April, 2009 to December, 2011 must be relocated firstly to get the precise hypocenter. We used catalogue data of P and S phase or P phase only and double-difference method to relocate the earthquakes. The results show hypocenter position enhancement that can be interpreted tectonically. The earthquakes after relocation relating to the Sumatran fault, subduction zone, volcanoes and seismic activities beneath Toba caldera can be mapped clearly. The relocated hypocenters in this study are very important to provide information for seismic hazard assessment and disaster mitigation study.

  3. 76 FR 48863 - Federal Travel Regulation (FTR); Relocation Allowances-Standard Mileage Rate for Moving Purposes

    Science.gov (United States)

    2011-08-09

    ... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION Federal Travel Regulation (FTR); Relocation Allowances--Standard Mileage Rate for Moving Purposes AGENCY: Office of Governmentwide Policy, General Services Administration (GSA). ACTION: Notice of...

  4. 75 FR 22805 - Federal Travel Regulation; Relocation Allowances; Standard Data Dictionary for Collection of...

    Science.gov (United States)

    2010-04-30

    ... online a proposed FTR bulletin that contains the data dictionary that large Federal agencies must use in... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION Federal Travel Regulation; Relocation Allowances; Standard Data Dictionary for Collection...

  5. 13 CFR 302.5 - Relocation assistance and land acquisition policies.

    Science.gov (United States)

    2010-01-01

    ..., DEPARTMENT OF COMMERCE GENERAL TERMS AND CONDITIONS FOR INVESTMENT ASSISTANCE § 302.5 Relocation assistance... (States and political subdivisions of States and non-profits organizations, as applicable) are subject...

  6. Modularization of Legacy Features by Relocation and Reconceptualization: How Much is Enough?

    DEFF Research Database (Denmark)

    Olszak, Andrzej; Jørgensen, Bo Nørregaard

    2012-01-01

    As programs become larger and start evolving, they often need to be split into modules, in order to facilitate independent evolution of end-user features and consolidate reusable core abstractions. Achieving this for legacy object-oriented software is, however, problematic due to scattering...... and tangling of feature implementations. While relocation of classes among packages can be used to significantly reduce these phenomena, achieving complete separation of features requires reconceptualization of existing classes. In this paper, we investigate the tradeoffs between relocation...

  7. Tunnel for relocation the river Krivelj permanent risk solution of possible critical aspects

    OpenAIRE

    Krstić, Slađana; Marinković, Goran; Ljubojev, Vesna

    2011-01-01

    Tailing dumps are one of the major environmental problems within the complex of RTB Bor. As the urgent priority of solving the environmental problems, a construction of tunnel for relocation the river Krivelj is at the top, what is a permanent solution of possible critical aspects of collector which is located below the tailing dump Veliki Krivelj. This paper analyzed the facts indicated a need for construction the tunnel for relocation the Krivelj river eliminating the risk of ecological dis...

  8. Mark Napier / Mark Napier ; interv. Tilman Baumgärtel

    Index Scriptorium Estoniae

    Napier, Mark

    2006-01-01

    Ameerika kunstnikust Mark Napierist (sünd. 1961) ja tema loomingust, 2001. a. tehtud meiliintervjuu kunstnikuga. Võrguteosest "The Digital Landfill" (1998), koos Andy Deckiga loodud tööst "GrafficJam" (1999), töödest "Shredder" (1998), "Feed", "Riot", "P-Soup" (2000), võrgukunstist ja muust

  9. Vastab Mark Lubotski / Mark Lubotski ; interv. Toomas Velmet

    Index Scriptorium Estoniae

    Lubotski, Mark

    2008-01-01

    Hamburgi Muusikakõrgkooli viiuliprofessor Mark Lubotskist, kes viibis Tallinnas oktoobris 2008 ja oli IV rahvusvahelise Heino Elleri nimelise viiuldajate konkursi žürii esimeheks. Tema sidemetest Eesti muusikutega, pagemisest Läände, Heino Elleri nimelisest konkursist ja tööst žüriis

  10. Mark Napier / Mark Napier ; interv. Tilman Baumgärtel

    Index Scriptorium Estoniae

    Napier, Mark

    2006-01-01

    Ameerika kunstnikust Mark Napierist (sünd. 1961) ja tema loomingust, 2001. a. tehtud meiliintervjuu kunstnikuga. Võrguteosest "The Digital Landfill" (1998), koos Andy Deckiga loodud tööst "GrafficJam" (1999), töödest "Shredder" (1998), "Feed", "Riot", "P-Soup" (2000), võrgukunstist ja muust

  11. Minimal Marking: A Success Story

    Directory of Open Access Journals (Sweden)

    Anne McNeilly

    2014-11-01

    Full Text Available The minimal-marking project conducted in Ryerson’s School of Journalism throughout 2012 and early 2013 resulted in significantly higher grammar scores in two first-year classes of minimally marked university students when compared to two traditionally marked classes. The “minimal-marking” concept (Haswell, 1983, which requires dramatically more student engagement, resulted in more successful learning outcomes for surface-level knowledge acquisition than the more traditional approach of “teacher-corrects-all.” Results suggest it would be effective, not just for grammar, punctuation, and word usage, the objective here, but for any material that requires rote-memory learning, such as the Associated Press or Canadian Press style rules used by news publications across North America.

  12. Precise hypocentre relocation of microearthquakes in a high-temperature geothermal field: the Torfajökull central volcano, Iceland

    Science.gov (United States)

    Lippitsch, Regina; White, Robert S.; Soosalu, Heidi

    2005-01-01

    The Torfajökull volcanic system is one of approximately 30 active volcanoes comprising the neovolcanic zones of Iceland. The central volcano of the system is the largest silicic centre in Iceland with a caldera of approximately 12 km diameter. Its high-temperature geothermal system is one of the most powerful in Iceland. Torfajökull is a source of persistent seismicity, where both high- and low-frequency earthquakes occur. To study this microseismicity in detail, a temporary array of 20 broad-band seismic stations was deployed between 2002 June and November. These temporary stations were embedded in the permanent South Iceland Lowland (SIL) network and data from nine adjacent SIL stations were included in this study. A minimum one-dimensional (1-D) velocity model with station corrections was computed for earthquake relocation by inverting manually picked P- and S-wave arrival times from events occurring in the Torfajökull volcanic centre and its surroundings. High-frequency earthquakes from the Torfajökull volcanic centre were then relocated calculating a non-linear, probabilistic solution to the earthquake location problem. Subsequently, we correlated the waveforms of these 121 events (~2000 observations) to define linked events, calculated the relative traveltime difference between event pairs and solved for the hypocentral separation between these events. The resulting high-resolution pattern shows a tighter clustering in epicentre and focal depth when compared with original locations. Earthquakes are mainly located beneath the caldera with hypocentres between 1 and 6 km depth and lie almost exclusively within the geothermal system. A sharp cut-off in seismicity at 3 km suggests either that there is a marked temperature increase or that this is a structural boundary. No seismic activity was observed in the fissure swarms to the northeast (NE) and southwest (SW) of the volcanic centre.

  13. Relocalization of cell adhesion molecules during neoplastic transformation of human fibroblasts.

    Science.gov (United States)

    Belgiovine, Cristina; Chiodi, Ilaria; Mondello, Chiara

    2011-11-01

    Studying neoplastic transformation of telomerase immortalized human fibroblasts (cen3tel), we found that the transition from normal to tumorigenic cells was associated with the loss of growth contact inhibition, the acquisition of an epithelial-like morphology and a change in actin organization, from stress fibers to cortical bundles. We show here that these variations were paralleled by an increase in N-cadherin expression and relocalization of different adhesion molecules, such as N-cadherin, α-catenin, p-120 and β-catenin. These proteins presented a clear membrane localization in tumorigenic cells compared to a more diffuse, cytoplasmic distribution in primary fibroblasts and non-tumorigenic immortalized cells, suggesting that tumorigenic cells could form strong cell-cell contacts and cell contacts did not induce growth inhibition. The epithelial-like appearance of tumorigenic cells did not reflect a mesenchymal-epithelial transition; in fact, cen3tel cells expressed vimentin and did not express cytokeratins at all transformation stages. Moreover, they did not express epithelial proteins such as occluding and claudin-1. In contrast, ZO-1 showed higher levels and a more defined membrane localization in tumorigenic cells compared to non-tumorigenic cells; this confirms its role in adherens junction formation in mesenchymal cells and is in agreement with the strong cell-cell contact formation by neoplastically transformed cells. Finally, we found α-catenin and ZO-1 nuclear localization in non-transformed cells, suggestive of possible additional roles of these proteins besides cell junction formation.

  14. SATB1 regulates {beta}-like globin genes through matrix related nuclear relocation of the cluster

    Energy Technology Data Exchange (ETDEWEB)

    Gong, Huan; Wang, Zhao; Zhao, Guo-wei; Lv, Xiang; Wei, Gong-hong; Wang, Li [National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing 100005 (China); Liu, De-pei, E-mail: liudp@pumc.edu.cn [National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing 100005 (China); Liang, Chih-chuan [National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing 100005 (China)

    2009-05-22

    The nuclear location and relocation of genes play crucial regulatory roles in gene expression. SATB1, a MAR-binding protein, has been found to regulate {beta}-like globin genes through chromatin remodeling. In this study, we generated K562 cells over-expressing wild-type or nuclear matrix targeting sequences (NMTS)-deficient SATB1 and found that like wild-type SATB1, NMTS-deficient SATB1 induces out loop of {beta}-globin cluster from its chromosome territory (CT), while it is unable to associate the cluster with the nuclear matrix as wild-type SATB1 does and had no regulatory functions to the {beta}-globin cluster. Besides, our data showed that the transacting factor occupancies and chromatin modifications at {beta}-globin cluster were differentially affected by wild-type and NMTS-deficient SATB1. These results indicate that SATB1 regulates {beta}-like globin genes at the nuclear level interlaced with chromatin and DNA level, and emphasize the nuclear matrix binding activity of SATB1 to its regulatory function.

  15. Relocation of the M8.0 Wenchuan earthquake and its aftershock sequence

    Institute of Scientific and Technical Information of China (English)

    HUANG Yuan; WU JianPing; ZHANG TianZhong; ZHANG DongNing

    2008-01-01

    We relocated MB.0 Wenchuan earthquake and 2706 aftershocks with M≥2.0 using double-difference algorithm and obtained relocations of 2553 events. To reduce the influence of lateral variation in crustal and upper mantle velocity structure, we used different velocity models for the east and west side of Longmenshan fault zone. In the relocation process, we added seismic data from portable seismic stations close to the shocks to constrain focal depths. The precisions in E-W, N-S, and U-D directions after relocation are 0.6, 0.7, and 2.5 km respectively. The relocation results show that the aftershock epicenters of Wenchuan earthquake were distributed in NE-SW direction, with a total length of about 330km. The aftershocks were concentrated on the west side of the central fault of Longmenshan fault zone,excluding those on the north of Qingchuan, which obviously deviated from the surface fault and passed through Pingwu-Qingchuan fault in the north. The dominant focal depths of the aftershocks are between 5 and 20 km, the average depth is 13.3 km, and the depth of the relocated main shock is 16.0km. The depth profile reveals that focal depth distribution in some of the areas is characterized by high-angle westward dipping. The rupture mode of the main shock features reverse faulting in the south, with a large strike-slip component in the north.

  16. Relocation of the M8.0 Wenchuan earthquake and its aftershock sequence

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    We relocated M8.0 Wenchuan earthquake and 2706 aftershocks with M≥2.0 using double-difference algorithm and obtained relocations of 2553 events. To reduce the influence of lateral variation in crustal and upper mantle velocity structure, we used different velocity models for the east and west side of Longmenshan fault zone. In the relocation process, we added seismic data from portable seismic sta-tions close to the shocks to constrain focal depths. The precisions in E-W, N-S, and U-D directions after relocation are 0.6, 0.7, and 2.5 km respectively. The relocation results show that the aftershock epi-centers of Wenchuan earthquake were distributed in NE-SW direction, with a total length of about 330 km. The aftershocks were concentrated on the west side of the central fault of Longmenshan fault zone, excluding those on the north of Qingchuan, which obviously deviated from the surface fault and passed through Pingwu-Qingchuan fault in the north. The dominant focal depths of the aftershocks are between 5 and 20 km, the average depth is 13.3 km, and the depth of the relocated main shock is 16.0 km. The depth profile reveals that focal depth distribution in some of the areas is characterized by high-angle westward dipping. The rupture mode of the main shock features reverse faulting in the south, with a large strike-slip component in the north.

  17. Displacement, Deprivation and Development: The Impact of Relocation on Income and Livelihood of Tribes in Similipal Tiger and Biosphere Reserve, India.

    Science.gov (United States)

    Mahapatra, Ajay Kumar; Tewari, D D; Baboo, Biplab

    2015-08-01

    A large volume of literature describes adverse consequences of conservation-induced displacement on indigenous communities depended on natural resources of wildlife habitat. Resettlement policies in protected areas the world over are mainly designed and implemented without consideration of social and economic costs of exclusion. This study examined income and poverty profile of tribal residents in Similipal Tiger and Biosphere Reserve in India, relative to the households relocated out of the reserve. The income from different sources and livelihood diversification of displaced reserve dwellers reflected changes resulting from the loss of access to natural and household assets. The results contradicted common perception about impoverishment outcome of relocation. It showed an increase in the per capita income for poorer segments with an overall 8% increase in absolute household income and corresponding improvement in the poverty ratio (head count ratio) and FGT index (0.241) for the relocated community. Contrary to other studies, the finding did not observe social alignment or marginalization; however, on-farm livelihood diversification reduced with increased dependence on off-farm sources. Expulsion of people from forest reserves to support conservation is inadequate in restricting habitat use of locals unless suitable alternative livelihood options are available for forest dependent was proven from the study.

  18. Displacement, Deprivation and Development: The Impact of Relocation on Income and Livelihood of Tribes in Similipal Tiger and Biosphere Reserve, India

    Science.gov (United States)

    Mahapatra, Ajay Kumar; Tewari, D. D.; Baboo, Biplab

    2015-08-01

    A large volume of literature describes adverse consequences of conservation-induced displacement on indigenous communities depended on natural resources of wildlife habitat. Resettlement policies in protected areas the world over are mainly designed and implemented without consideration of social and economic costs of exclusion. This study examined income and poverty profile of tribal residents in Similipal Tiger and Biosphere Reserve in India, relative to the households relocated out of the reserve. The income from different sources and livelihood diversification of displaced reserve dwellers reflected changes resulting from the loss of access to natural and household assets. The results contradicted common perception about impoverishment outcome of relocation. It showed an increase in the per capita income for poorer segments with an overall 8 % increase in absolute household income and corresponding improvement in the poverty ratio (head count ratio) and FGT index (0.241) for the relocated community. Contrary to other studies, the finding did not observe social alignment or marginalization; however, on-farm livelihood diversification reduced with increased dependence on off-farm sources. Expulsion of people from forest reserves to support conservation is inadequate in restricting habitat use of locals unless suitable alternative livelihood options are available for forest dependent was proven from the study.

  19. Two Stories about Mark Twain

    Institute of Scientific and Technical Information of China (English)

    张策; 李秀云

    2004-01-01

    ⅠAsyouknow,MarkTwainwasafamousAmericanwriterandJamesWhistlerwasafa-mouspainter.TwainlikedWhistler’sworkverymuch,andthere’sastoryaboutthedayhevisitedWhistlerinhisstudio.Whistlerwasaratherseriousperson,butTwainen-joyedjokes.TwainwalkedroundthestudiolookingatWhistler’swonderfulpaintings.“Ilikethispictureofthesea,”Twainsaid.“Yes,Ipainteditsometimeago.It’scalled‘AngrySea’.”“Thecolorsarebeautiful,”Twainsaid.Thenhepointedatanotherpicture.“Ilikethewaythewomanisstandinginthepicture.Ilikethewayshe’slookingoutofthewin...

  20. Business Education Receives High Marks.

    Science.gov (United States)

    Yopp, Martha C.; Brumley, Debbie

    1996-01-01

    A national survey of state superintendents of public instruction (n=35) and state directors of employment and training (n=28) gives business education programs, courses, and competencies high marks. Suggests that business educators should take advantage of this support by becoming more active in professional organizations. (JOW)

  1. Visual marking of old objects

    NARCIS (Netherlands)

    Theeuwes, J.; Kramer, A.F.; Atchley, P.

    1998-01-01

    Watson and Humphreys (1997) presented evidence that selection of new elements can be prioritized by on-line top-down attentional inhibition of old stimuli already in the visual field (visual marking). The experiments on which this evidence was based always presented old elements in green and new ele

  2. Arabidopsis HIT4, a regulator involved in heat-triggered reorganization of chromatin and release of transcriptional gene silencing, relocates from chromocenters to the nucleolus in response to heat stress.

    Science.gov (United States)

    Wang, Lian-Chin; Wu, Jia-Rong; Hsu, Yi-Ju; Wu, Shaw-Jye

    2015-01-01

    Arabidopsis HIT4 is known to mediate heat-induced decondensation of chromocenters and release from transcriptional gene silencing (TGS) with no change in the level of DNA methylation. It is unclear whether HIT4 and MOM1, a well-known DNA methylation-independent transcriptional silencer, have overlapping regulatory functions. A hit4-1/mom1 double mutant strain was generated. Its nuclear morphology and TGS state were compared with those of wild-type, hit4-1, and mom1 plants. Fluorescent protein tagging was employed to track the fates of HIT4, hit4-1 and MOM1 in vivo under heat stress. HIT4- and MOM1-mediated TGS were distinguishable. Both HIT4 and MOM1 were localized normally to chromocenters. Under heat stress, HIT4 relocated to the nucleolus, whereas MOM1 dispersed with the chromocenters. hit4-1 was able to relocate to the nucleolus under heat stress, but its relocation was insufficient to trigger the decompaction of chromocenters. The hypersensitivity to heat associated with the impaired reactivation of TGS in hit4-1 was not alleviated by mom1-induced release from TGS. HIT4 delineates a novel and MOM1-independent TGS regulation pathway. The involvement of a currently unidentified component that links HIT4 relocation and the large-scale reorganization of chromatin, and which is essential for heat tolerance in plants is hypothesized.

  3. Poly(A)-Binding Protein 1 Partially Relocalizes to the Nucleus during Herpes Simplex Virus Type 1 Infection in an ICP27-Independent Manner and Does Not Inhibit Virus Replication▿

    Science.gov (United States)

    Salaun, C.; MacDonald, A. I.; Larralde, O.; Howard, L.; Lochtie, K.; Burgess, H. M.; Brook, M.; Malik, P.; Gray, N. K.; Graham, S. V.

    2010-01-01

    Infection of cells by herpes simplex virus type 1 (HSV-1) triggers host cell shutoff whereby mRNAs are degraded and cellular protein synthesis is diminished. However, virus protein translation continues because the translational apparatus in HSV-infected cells is maintained in an active state. Surprisingly, poly(A)-binding protein 1 (PABP1), a predominantly cytoplasmic protein that is required for efficient translation initiation, is partially relocated to the nucleus during HSV-1 infection. This relocalization occurred in a time-dependent manner with respect to virus infection. Since HSV-1 infection causes cell stress, we examined other cell stress inducers and found that oxidative stress similarly relocated PABP1. An examination of stress-induced kinases revealed similarities in HSV-1 infection and oxidative stress activation of JNK and p38 mitogen-activated protein (MAP) kinases. Importantly, PABP relocalization in infection was found to be independent of the viral protein ICP27. The depletion of PABP1 by small interfering RNA (siRNA) knockdown had no significant effect on viral replication or the expression of selected virus late proteins, suggesting that reduced levels of cytoplasmic PABP1 are tolerated during infection. PMID:20573819

  4. Biorefineries: Relocating Biomass Refineries to the Rural Area

    Directory of Open Access Journals (Sweden)

    Franka Papendiek

    2012-07-01

    Full Text Available The field for application of biomass is rising. The demand for food and feeding stuff rises while at the same time energy, chemicals and other materials also need to be produced from biomass because of decreasing fossil resources. However, the biorefinery ideas and concepts can help to use the limited renewable raw materials more efficiently than today. With biorefineries, valuable products, such as platform chemicals, can be produced from agricultural feedstock, which can subsequently be further processed into a variety of substances by the chemical industry. Due to the role they play as producers of biomass, rural areas will grow in importance in the decades to come. Parts of the biorefinery process can be relocated to the rural areas to bring a high added value to these regions. By refining biomass at the place of production, new economic opportunities may arise for agriculturists, and the industry gets high-grade pre-products. Additionally, an on-farm refining can increase the quality of the products because of the instant processing. To reduce competition with the food production and to find new possibilities of utilisation for these habitats, the focus for new agricultural biomass should be on grasslands. But also croplands can provide more renewable raw materials without endangering a sustainable agriculture, e.g. by implementing legumes in the crop rotation. To decide if a region can provide adequate amounts of raw material for a biorefinery, new raw material assessment procedures have to be developed. In doing so, involvement of farmers is inevitable to generate a reliable study of the biomass refinery potentials.

  5. 49 CFR 1520.13 - Marking SSI.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Marking SSI. 1520.13 Section 1520.13... SECURITY INFORMATION § 1520.13 Marking SSI. (a) Marking of paper records. In the case of paper records containing SSI, a covered person must mark the record by placing the protective marking conspicuously on the...

  6. Chorionic Villus Sampling and Marked Membrane Separation

    Directory of Open Access Journals (Sweden)

    Sh. Akhlaghpoor

    2010-12-01

    Full Text Available Background/Objective: The major concern about the invasive prenatal diagnostic tests is the"nfrequency of procedure induced pregnancy loss. Chorionic Villus Sampling (CVS is the invasive"ntest of choice in the first trimester after the 10th gestational week. Our experience suggests"nmarked chorioamniotic separation is an uncommon finding after the 10th gestational week. This"nstudy assesses the rate of marked membrane separation in a 10 to 14-week gestational period"nand its effect on post CVS fetal loss."nPatients and Methods: Forty-one patients (5.2% were selected among 782 patients as cases"nwith marked membrane separation (mean maternal age, 26.9 years. CVS procedures were"nperformed with a 20-gauge Chiba needle attached to a 20-ml syringe under ultrasound guidance."nFollow-up was performed by phone call and clinical visits until 24 weeks of gestation. For the"ncontrol group, the follow-up was performed for only 2 weeks. Early fetal loss in the first two"nweeks of post procedural period, and late fetal loss from 2 weeks after procedure till the 24th"ngestational week were considered as CVS complications."nResults: We detected 2.4% early fetal losses after the procedure. Fourteen cases voluntarily"nunderwent therapeutic abortion due to beta-thalassemia or hemophilia. One fetus with"nmicrocephaly was spontaneously aborted in the 21st gestational week. Twenty-five neonates"nwere delivered alive at term and one prematurely at the 32nd week. Marked membrane separation"nhad no significant effect on early post CVS fetal loss rate."nConclusion: The procedure does not have a major impact on the early post CVS fetal loss in"npatients with marked membrane separation.

  7. Overlay mark optimization for thick-film resist overlay metrology

    Institute of Scientific and Technical Information of China (English)

    Zhu Liang; Li Jie; Zhou Congshu; Gu Yili; Yang Huayue

    2009-01-01

    For thick resist implant layers, such as a high voltage P well and a deep N well, systematic and uncorrectable overlay residues brought about by the tapered resist profiles were found. It was found that the tapered profile is closely related to the pattern density. Potential solutions of the manufacturing problem include hardening the film solidness or balancing the exposure density. In this paper, instead of focusing on the process change methodology,we intend to solve the issue of the overlay metrology error from the perspective of the overlay mark design. Based on the comparison of the overlay performances between the proposed overlay mark and the original design, it is shown that the optimized overlay mark target achieves better performance in terms of profiles, dynamic precision,tool induced shift (TIS), and residues. Furthermore, five types of overlay marks with dummy bars are studied, and a recommendation for the overlay marks is given.

  8. Comparative study of human mitochondrial proteome reveals extensive protein subcellular relocalization after gene duplications

    Directory of Open Access Journals (Sweden)

    Huang Yong

    2009-11-01

    Full Text Available Abstract Background Gene and genome duplication is the principle creative force in evolution. Recently, protein subcellular relocalization, or neolocalization was proposed as one of the mechanisms responsible for the retention of duplicated genes. This hypothesis received support from the analysis of yeast genomes, but has not been tested thoroughly on animal genomes. In order to evaluate the importance of subcellular relocalizations for retention of duplicated genes in animal genomes, we systematically analyzed nuclear encoded mitochondrial proteins in the human genome by reconstructing phylogenies of mitochondrial multigene families. Results The 456 human mitochondrial proteins selected for this study were clustered into 305 gene families including 92 multigene families. Among the multigene families, 59 (64% consisted of both mitochondrial and cytosolic (non-mitochondrial proteins (mt-cy families while the remaining 33 (36% were composed of mitochondrial proteins (mt-mt families. Phylogenetic analyses of mt-cy families revealed three different scenarios of their neolocalization following gene duplication: 1 relocalization from mitochondria to cytosol, 2 from cytosol to mitochondria and 3 multiple subcellular relocalizations. The neolocalizations were most commonly enabled by the gain or loss of N-terminal mitochondrial targeting signals. The majority of detected subcellular relocalization events occurred early in animal evolution, preceding the evolution of tetrapods. Mt-mt protein families showed a somewhat different pattern, where gene duplication occurred more evenly in time. However, for both types of protein families, most duplication events appear to roughly coincide with two rounds of genome duplications early in vertebrate evolution. Finally, we evaluated the effects of inaccurate and incomplete annotation of mitochondrial proteins and found that our conclusion of the importance of subcellular relocalization after gene duplication on

  9. Mark Twain: inocente ou pecador? = Mark Twain: innocent or sinner?

    Directory of Open Access Journals (Sweden)

    Heloisa Helou Doca

    2009-01-01

    Full Text Available A leitura cuidadosa do texto do “Tratado de Paris”, em 1900, leva Mark Twain a concluir que a intenção política norte-americana era, claramente, a de subjugação. Declara-se, abertamente, antiimperialista, nesse momento, apesar das inúmeras críticasrecebidas por antagonistas políticos que defendiam o establishment dos Estados Unidos. Após viajar para a Europa e Oriente, em 1867, como correspondente do jornal Daily Alta Califórnia, Mark Twain publica, em 1869, seu relato de viagem, The Innocents Abroad or TheNew Pilgrim’s Progress. Nosso estudo demonstra que o autor, apesar das diversas máscaras usadas em seus relatos, narra histórias, culturas e tradições, tanto da Europa quanto do Oriente, já com os olhos bem abertos pelo viés antiimperialista. Faz uso da paródia, sátira, ironia e humor para dessacralizar impérios, monarcas e a Igreja que subjugavam os mais fracos, iluminando, desde então, os estudos sobre culturas. Nosso estudo, outrossim, faz uma reflexão sobre cultura, tradição e o olhar do viajante, justificando o “olhar inocente” do narrador em seu relato.After carefully reading the Treaty of Paris in 1900, Mark Twain concluded that the goal of U.S. policy was clearly one ofsubjugation. He openly declared himself an anti-imperialist at that time, in spite of the numerous criticisms he received from political opponents who supported the United States status quo. After traveling to Europe and the East in 1867 as a correspondent for The DailyAlta California newspaper, Mark Twain published his travel report, The Innocents Abroad or The New Pilgrim’s Progress in 1869. Our study demonstrates that the author, in spite of using different guises in his reports, narrated histories, cultures and traditions – from both Europe and the East – with a viewpoint already imbued by his anti-imperialistic ideals. Twain made use of parody, satire, irony and humor within his texts in order to desecrate empires,monarchs and

  10. First Results from the Relocated and Enhanced Purple Crow Lidar

    Science.gov (United States)

    Wing, R.; Argall, P. S.; Bandoro, J.; Khanna, J.; McCullough, E. M.; Sica, R. J.

    2011-12-01

    The University of Western Ontario's Purple Crow Lidar (PCL) has been in near continuous operation since 1993 and routinely measures temperature from 10 km to above 100 km, water vapor mixing ratio in the troposphere and stratosphere, as well as aerosol products. The PCL was recently relocated to a new custom-built, environmentally friendly facility at Western's Environmental Research Station located 9 km north of the campus. The PCL move allowed the opportunity for many new and exciting instrumentation upgrades and improvements. Our new transmitter, a Litron Nd:YAG laser, produces 1000 mJ/pulse at 532 nm with a 30 Hz repetition rate (i.e. 30 W). This new laser increases our transmitter power by 2.5 times compared to our previous laser and boosts the PCL's power-aperture product to 160 W/m2. We have also upgraded the counting electronics to improve the vertical height resolution of our Rayleigh temperature from 24 m to 7.5 m and our water vapour, vibrational Raman temperature, and aerosol measurements from 250 m to 24 m. As well, the system is now capable of automatic alignment during operations. The water vapor measurements have been further improved by the addition of a white light calibration source. We are in the process of upgrading the system for more direct aerosol measurements by including a low altitude aerosol channel using a small co-aligned telescope. The enhanced system will have two major impacts on upper mesosphere/lower thermosphere science. First, our new laser will allow our temperature measurements to gain another 10 km in altitude, pushing them at times above 110 km. Second, due to the new inversion method developed by Khanna (2011), an assumption of a seed pressure at the top of the atmosphere will no longer be required, so any systematic retrieval uncertainties will be less than the measurement statistical uncertainty in the lower thermosphere. With the seeding of the temperature profiles now done at the lowest heights (i.e. stratosphere), the

  11. Moonquake Relocation%月震重定位

    Institute of Scientific and Technical Information of China (English)

    赵娜; 朱培民; 张秉政; 袁悦锋

    2015-01-01

    由于前人的月震定位结果主要是基于20世纪70、80年代的月球速度模型,定位结果误差较大,无法为月震层析成像等研究提供精确的月震参数。随着对月球内部结构研究的不断深入,月球速度模型及分层结构的精细程度已经有了很大提高。通过对 Apollo 月震数据解码及分析,重新拾取了月震初至数据,在总结前人震源定位的基础上,利用月球新近速度模型,采用Geiger 震源定位方法进行了月震震源定位,给出了较为全面的月震参数目录,并对月震和地震的分布及形成机制进行了对比,可为以后月震及月球内部结构的深入研究提供更多的依据。%Existing parameters for tomography and relevant research about the moonquakes are not necessarily accurate due to he low precision of moonquake location resulted from outdated velocity models published during last century.However,the accuracy of lunar velocity model and stratigraphic structure has been improved greatly thanks to latest studies on lunar internal structure.This paper se-lects new arrival times from Apollo moonquake data,and relocates the moonquakes using Geiger method based on the latest lunar ve-locity model.In addition,the differences of distribution and mechanism between moonquakes and earthquakes are analyzed.This study can offer more information for further research of moonquakes and lunar internal structure.

  12. Relocation of the 1998 Zhangbei-Shangyi earthquake sequence using the double difference earthquake location algorithm

    Institute of Scientific and Technical Information of China (English)

    杨智娴; 陈运泰

    2004-01-01

    On January 10, 1998, at 11h50min Beijing Time (03h50min UTC), an earthquake of ML=6.2 occurred in the border region between the Zhangbei County and Shangyi County of Hebei Province. This earthquake is the most significant event to have occurred in northern China in the recent years. The earthquake-generating structure of this event was not clear due to no active fault capable of generating a moderate earthquake was found in the epicentral area,nor surface ruptures with any predominate orientation were observed, no distinct orientation of its aftershock distribution given by routine earthquake location was shown. To study the seismogenic structure of the ZhangbeiShangyi earthquake, the main shock and its aftershocks with ML≥3.0 of the Zhangbei-Shangyi earthquake sequence were relocated by the authors of this paper in 2002 using the master event relative relocation technique.The relocated epicenter of the main shock was located at 41.145°N, 114.462°E, which was located 4 km to the NE of the macro-epicenter of this event. The relocated focal depth of the main shock was 15 km. Hypocenters of the aftershocks distributed in a nearly vertical plane striking 180°~200° and its vicinity. The relocated results of the Zhangbei-Shangyi earthquake sequence clearly indicated that the seismogenic structure of this event was a NNE-SSW-striking fault with right-lateral and reverse slip. In this paper, a relocation of the Zhangbei-Shangyi earthquake sequence has been done using the double difference earthquake location algorithm (DD algorithm), and consistent results with that obtained by the master event technique were obtained. The relocated hypocenters of the main shock are located at 41.131 °N, 114.456°E, which was located 2.5 km to the NE of the macro-epicenter of the main shock. The relocated focal depth of the main shock was 12.8 km. Hypocenters of the aftershocks also distributed in a nearly vertical N10°E-striking plane and its vicinity. The relocated results

  13. The willingness to relocate to another country: the impact of cultural similarity, destination safety, and financial incentive.

    Science.gov (United States)

    Wagner, Michael R; Westaby, James D

    2009-08-01

    Because of increased concerns about terrorism around the globe, international organizations are very interested in understanding how safety and cultural issues impact their employees' willingness to relocate abroad. This has been especially true for international companies based in the United States, given the recent salience of US activities around the world. Additionally, questions remain regarding the efficacy of financial incentives to motivate individuals' willingness to relocate when the destination may be dangerous. Therefore, the factors impacting willingness to relocate from the US to another country were examined experimentally in this study. Based upon theory and research in social and organizational psychology, it was hypothesized that cultural similarity, destination safety, and financial incentives would have direct effects on individuals' willingness to accept relocation offers. It was also predicted that cultural similarity and destination safety would moderate the effects of incentives upon willingness to relocate. The study used a 2 × 2 × 3 between-subjects design manipulating destination similarity (similar, different), destination safety (safe, dangerous), and bonus for relocating (0% bonus, 20% bonus, 40% bonus). Results from 196 participants at a university in the northeastern part of the US revealed that financial incentives and safety perceptions directly impacted willingness to relocate. In line with moderator predictions, financial incentives had a stronger effect on willingness to relocate when the destination was culturally different from the United States than when it was similar. Against expectations, there was no interaction between financial incentives and safety. Destination safety perceptions were relatively strong determinants of willingness to relocate.

  14. Robustness of survival estimates for radio-marked animals

    Science.gov (United States)

    Bunck, C.M.; Chen, C.-L.

    1992-01-01

    Telemetry techniques are often used to study the survival of birds and mammals; particularly whcn mark-recapture approaches are unsuitable. Both parametric and nonparametric methods to estimate survival have becn developed or modified from other applications. An implicit assumption in these approaches is that the probability of re-locating an animal with a functioning transmitter is one. A Monte Carlo study was conducted to determine the bias and variance of the Kaplan-Meier estimator and an estimator based also on the assumption of constant hazard and to eva!uate the performance of the two-sample tests associated with each. Modifications of each estimator which allow a re-Iocation probability of less than one are described and evaluated. Generallv the unmodified estimators were biased but had lower variance. At low sample sizes all estimators performed poorly. Under the null hypothesis, the distribution of all test statistics reasonably approximated the null distribution when survival was low but not when it was high. The power of the two-sample tests were similar.

  15. Work environment perceptions following relocation to open-plan offices: A twelve-month longitudinal study.

    Science.gov (United States)

    Bergström, Jessica; Miller, Michael; Horneij, Eva

    2015-01-01

    A workplace's design can have various positive or negative effects on the employees and since the 1970s the advantages and disadvantages of open-plan offices have been discussed. The aim of this study was to investigate perceived health, work environment and self-estimated productivity one month before and at three, six and twelve months after relocation from individual offices to an open-plan office environment. Employees from three departments within the same company group and who worked with relatively similar tasks and who were planned to be relocated from private offices to open-plan offices were invited to participate. Questionnaires comprising items from The Salutogenic Health Indicator Scale, The Work Experience Measurement Scale, the questionnaire by Brennan et al. about perceived performance and one question from the Work Ability Index were sent to participants one month before relocation (baseline) to open-plan offices and then at three, six and twelve months after relocation. At baseline, 82 questionnaires were sent out. The response rate was 85%. At the follow-ups 77-79 questionnaires were sent out and the response-rate was 70%-81%. At follow-ups, perceived health, job satisfaction and performance had generally deteriorated. The results of the study indicate that employees' perception of health, work environment and performance decreased during a 12 month period following relocation from individual offices to open-plan offices.

  16. Methods study for the relocation of visual information in central scotoma cases

    Science.gov (United States)

    Scherlen, Anne-Catherine; Gautier, Vincent

    2005-03-01

    In this study we test the benefit on the reading performance of different ways to relocating the visual information present under the scotoma. The relocation (or unmasking) allows to compensate the loss of information and avoid the patient developing driving strategies not adapted for the reading. Eight healthy subjects were tested on a reading task, on each a central scotoma of various sizes was simulated. We then evaluate the reading speed (words/min) during three visual information relocation methods: all masked information is relocated - on both side of scotoma, - on the right of scotoma, - and only essentials letters for the word recognition too on the right of scotoma. We compare these reading speeds versus the pathological condition, ie without relocating visual information. Our results show that unmasking strategy improve the reading speed when all the visual information is unmask to the right of scotoma, this only for large scotoma. Taking account the word morphology, the perception of only certain letters outside the scotoma can be sufficient to improve the reading speed. A deepening of reading processes in the presence of a scotoma will then allows a new perspective for visual information unmasking. Multidisciplinary competences brought by engineers, ophtalmologists, linguists, clinicians would allow to optimize the reading benefit brought by the unmasking.

  17. Laser therapy of stretch marks.

    Science.gov (United States)

    McDaniel, David H

    2002-01-01

    Striae distensae, better known as stretch marks, are a common disfiguring skin disorder of significant cosmetic concern. Many sources have reported the use of lasers to diminish the appearance of striae. Controlled clinical studies of the various treatment modalities available for striae are relatively uncommon, and much of the clinical data are anecdotal. The use of lasers alone or in combination with other therapeutic modalities can provide a safe and effective reduction in the appearance of both red and white striae distensae. Many of these therapies require special measures for darker skin phototypes. This article reviews the historical use of laser therapy for this disorder and discusses current therapeutic options.

  18. 49 CFR 221.14 - Marking devices.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Marking devices. 221.14 Section 221.14..., DEPARTMENT OF TRANSPORTATION REAR END MARKING DEVICE-PASSENGER, COMMUTER AND FREIGHT TRAINS Marking Devices § 221.14 Marking devices. (a) As prescribed in § 221.13, passenger, commuter and freight trains shall...

  19. 27 CFR 28.154 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.154..., for Exportation or Transfer to a Foreign-Trade Zone § 28.154 Export marks. In addition to the marks... provisions of part 19 of this chapter, the proprietor shall mark the word “Export” on the Government side of...

  20. 27 CFR 28.193 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.193... Drawback Filing of Notice and Removal § 28.193 Export marks. In addition to the marks and brands required... chapter, the exporter shall mark the word “Export” on the Government side of each case or Government head...

  1. 27 CFR 28.103 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.103... Manufacturing Bonded Warehouse § 28.103 Export marks. (a) General. In addition to the marks and brands required... provisions of part 19 of this chapter, the proprietor shall mark the word “Export” on the Government side of...

  2. 27 CFR 28.144 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.144... § 28.144 Export marks. (a) General Requirement. In addition to the marks and brands required to be... brewer shall mark the word “Export” on each container or case of beer, or the words “Beer concentrate for...

  3. Negotiating a Concurrence: Tracing the Visible/Invisible Relocation within Migrant-Inhabited Cities of China

    Directory of Open Access Journals (Sweden)

    Xueni Peng

    2015-04-01

    China’s internal migrants experience hardship akin to those undergone by overseas immigrants. In this respect, migration in China is an experience that begins before people move away from their place of origin and continues long after arriving in their new home destinations. As a unique feature of migration research, national relocation is not simply crossing a geographical boundary, but also transgressing social and psychological environment barriers. Our research intends to examine the underestimated or marginal character played by such outsider crowds with special regard given to the individual’s experience of ‘unfamiliar settlements. This involves exploring the role of migrants’ transformation through the misapprehension that relocation is merely a geographical movement. We suggest that visible relocation brings other incidental replacements (such as changes in identity, psychological cognition and social cohesion.

  4. Comparison tomography relocation hypocenter grid search and guided grid search method in Java island

    Science.gov (United States)

    Nurdian, S. W.; Adu, N.; Palupi, I. R.; Raharjo, W.

    2016-11-01

    The main data in this research is earthquake data recorded from 1952 to 2012 with 9162 P wave and 2426 events are recorded by 30 stations located around Java island. Relocation hypocenter processed using grid search and guidded grid search method. Then the result of relocation hypocenter become input for tomography pseudo bending inversion process. It can be used to identification the velocity distribution in subsurface. The result of relocation hypocenter by grid search and guided grid search method after tomography process shown in locally and globally. In locally area grid search method result is better than guided grid search according to geological reseach area. But in globally area the result of guided grid search method is better for a broad area because the velocity variation is more diverse than the other one and in accordance with local geological research conditions.

  5. Optimal timing for managed relocation of species faced with climate change

    Science.gov (United States)

    McDonald Madden, Eve; Runge, Michael C.; Possingham, Hugh P.; Martin, Tara G.

    2011-01-01

    Managed relocation is a controversial climate-adaptation strategy to combat negative climate change impacts on biodiversity. While the scientific community debates the merits of managed relocation, species are already being moved to new areas predicted to be more suitable under climate change. To inform these moves, we construct a quantitative decision framework to evaluate the timing of relocation in the face of climate change. We find that the optimal timing depends on many factors, including the size of the population, the demographic costs of translocation and the expected carrying capacities over time in the source and destination habitats. In some settings, such as when a small population would benefit from time to grow before risking translocation losses, haste is ill advised. We also find that active adaptive management is valuable when the effect of climate change on source habitat is uncertain, and leads to delayed movement.

  6. Earthquake relocation in Mollucas Sea using teleseismic double difference method for tectonic setting analysis

    Science.gov (United States)

    Setiadi, Tio Azhar Prakoso; Rohadi, Supriyanto; Heryandoko, Nova

    2017-07-01

    Earthquake hypocenter relocation is need to be done to get a better earthquake location with high accuracy so tectonic setting, and seismicity analysis can be get and done for further studies. One of some method to relocate earthquake is teleseismic Double-Difference that used 3D velocity model. This research is done by relocating 7042 of 8845 available earthquakes from January 1st 2009 - June 12th 2016 in Moluccas Sea. The result are better earthquake depths, showed by no more fixed depth earthquakes and hypocenter distribution shows subduction pattern which is assossiated to Moluccas Sea Plate. Subducting Plate of Moluccas Sea below Sangihe is getting deeper more way it gets north (± 580 km) and sloping to the south (± 280 km) and the subducting Moluccas Sea below Halmahera Arc is 250 km depth on average. Another result is a rollback of Phillipine plate is found that moves along with Moluccas Sea plate which is subducting below Halmahera Arc.

  7. Seismicity studies at Moluccas area based on the result of hypocenter relocation using HypoDD

    Science.gov (United States)

    Utama, Muhammad Reza July; Nugraha, Andri Dian; Puspito, Nanang T.

    2015-04-01

    The precise hypocenter was determined location using double difference method around subduction zone in Moluccas area eastern part of Indonesia. The initial hypocenter location from MCGA data catalogue of 1,945 earthquake events. Basically the principle of double-difference algorithm assumes if the distance between two earthquake hypocenter distribution is very small compared to the distance between the station to the earthquake source, the ray path can be considered close to both earthquakes. The results show the initial earthquakes with a certain depth (fix depth 10 km) relocated and can be interpreted more reliable in term of seismicity and geological setting. The relocation of the intra slab earthquakes beneath Banda Arc are also clearly observed down to depth of about 400 km. The precise relocated hypocenter will give invaluable seismicity information for other seismological and tectonic studies especially for seismic hazard analysis in this region.

  8. Seismicity studies at Moluccas area based on the result of hypocenter relocation using HypoDD

    Energy Technology Data Exchange (ETDEWEB)

    Utama, Muhammad Reza July, E-mail: muhammad.reza@bmkg.go.id [Student of Geophysical Engineering Study Program, Institute of Technology Bandung (Indonesia); Indonesian Meteorological, Climatological and Geophysical Agency (MCGA), Jakarta (Indonesia); Nugraha, Andri Dian; Puspito, Nanang T. [Global Geophysical Research Group, Faculty of Mining and Petroleum Engineering, ITB (Indonesia)

    2015-04-24

    The precise hypocenter was determined location using double difference method around subduction zone in Moluccas area eastern part of Indonesia. The initial hypocenter location from MCGA data catalogue of 1,945 earthquake events. Basically the principle of double-difference algorithm assumes if the distance between two earthquake hypocenter distribution is very small compared to the distance between the station to the earthquake source, the ray path can be considered close to both earthquakes. The results show the initial earthquakes with a certain depth (fix depth 10 km) relocated and can be interpreted more reliable in term of seismicity and geological setting. The relocation of the intra slab earthquakes beneath Banda Arc are also clearly observed down to depth of about 400 km. The precise relocated hypocenter will give invaluable seismicity information for other seismological and tectonic studies especially for seismic hazard analysis in this region.

  9. The managerial issues related to transferring shop floor knowledge in manufacturing relocation

    DEFF Research Database (Denmark)

    Knudsen, Mette Præst; Madsen, Erik Skov

    2014-01-01

    Purpose – The purpose of this paper is to explore the specific practices of management in the dispatching unit and to identify mechanisms for supporting transfer of shop floor knowledge embedded in operating manufacturing equipment. Design/methodology/approach – The paper applies an inductive...... and a case study approach for exploring three empirical cases that represent different manufacturing facility relocation processes and differences in the applied managerial practices. Findings – The paper identifies two important gaps in international production literature when firms relocate equipment...... to other sites; a time gap (from dismantling to re-assembly of production facilities) and a space gap (from the current to the new site abroad). These gaps are important for understanding why relocation processes are difficult and what management can do to facilitate such processes. Practical implications...

  10. Pellet relocation testing results for four-foot-long tritium target rods

    Energy Technology Data Exchange (ETDEWEB)

    McKinnon, M.A.; Harding, N.E.

    1992-05-01

    This report discusses four-foot-long sections of a new production light-water reactor (NP-LWR) generic tritium target rod which were tested to determine if the length of the pellet pencils affects the amount of pellet material relocated during a burst and to characterize the burst. This testing was conducted as a follow-on study of cladding strength and pellet relocation behavior of short target rod specimens [11 cm (4-4 in.)]. The results of these tests could be used to support safety analyses of the effects of rod bursting and pellet relocation on the performance of a NP-LWR reactor core during a postulated loss-of-coolant accident (LOCA). All burst tests of the target rods were performed in air because air is more reactive than the air-steam or water environment that accompanies a LOCA.

  11. Performance Analysis of a Forecasting Relocation Model for One-Way Carsharing

    Directory of Open Access Journals (Sweden)

    Ganjar Alfian

    2017-06-01

    Full Text Available A carsharing service can be seen as a transport alternative between private and public transport that enables a group of people to share vehicles based at certain stations. The advanced carsharing service, one-way carsharing, enables customers to return the car to another station. However, one-way implementation generates an imbalanced distribution of cars in each station. Thus, this paper proposes forecasting relocation to solve car distribution imbalances for one-way carsharing services. A discrete event simulation model was developed to help evaluate the proposed model performance. A real case dataset was used to find the best simulation result. The results provide a clear insight into the impact of forecasting relocation on high system utilization and the reservation acceptance ratio compared to traditional relocation methods.

  12. Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expression and localization of the immediate early protein ICP0

    Directory of Open Access Journals (Sweden)

    Kimura Hiroshi

    2011-05-01

    Full Text Available Abstract Background Herpes simplex viruses (HSVs rapidly shut off macromolecular synthesis in host cells. In contrast, global microarray analyses have shown that HSV infection markedly up-regulates a number of host cell genes that may play important roles in HSV-host cell interactions. To understand the regulatory mechanisms involved, we initiated studies focusing on the zinc finger transcription factor insulinoma-associated 1 (INSM1, a host cell protein markedly up-regulated by HSV infection. Results INSM1 gene expression in HSV-1-infected normal human epidermal keratinocytes increased at least 400-fold 9 h after infection; INSM1 promoter activity was also markedly stimulated. Expression and subcellular localization of the immediate early HSV protein ICP0 was affected by INSM1 expression, and chromatin immunoprecipitation (ChIP assays revealed binding of INSM1 to the ICP0 promoter. Moreover, the role of INSM1 in HSV-1 infection was further clarified by inhibition of HSV-1 replication by INSM1-specific siRNA. Conclusions The results suggest that INSM1 up-regulation plays a positive role in HSV-1 replication, probably by binding to the ICP0 promoter.

  13. Nest Enlargement in Leaf-Cutting Ants: Relocated Brood and Fungus Trigger the Excavation of New Chambers

    Science.gov (United States)

    Römer, Daniela; Roces, Flavio

    2014-01-01

    During colony growth, leaf-cutting ants enlarge their nests by excavating tunnels and chambers housing their fungus gardens and brood. Workers are expected to excavate new nest chambers at locations across the soil profile that offer suitable environmental conditions for brood and fungus rearing. It is an open question whether new chambers are excavated in advance, or will emerge around brood or fungus initially relocated to a suitable site in a previously-excavated tunnel. In the laboratory, we investigated the mechanisms underlying the excavation of new nest chambers in the leaf-cutting ant Acromyrmex lundi. Specifically, we asked whether workers relocate brood and fungus to suitable nest locations, and to what extent the relocated items trigger the excavation of a nest chamber and influence its shape. When brood and fungus were exposed to unfavorable environmental conditions, either low temperatures or low humidity, both were relocated, but ants clearly preferred to relocate the brood first. Workers relocated fungus to places containing brood, demonstrating that subsequent fungus relocation spatially follows the brood deposition. In addition, more ants aggregated at sites containing brood. When presented with a choice between two otherwise identical digging sites, but one containing brood, ants' excavation activity was higher at this site, and the shape of the excavated cavity was more rounded and chamber-like. The presence of fungus also led to the excavation of rounder shapes, with higher excavation activity at the site that also contained brood. We argue that during colony growth, workers preferentially relocate brood to suitable locations along a tunnel, and that relocated brood spatially guides fungus relocation and leads to increased digging activity around them. We suggest that nest chambers are not excavated in advance, but emerge through a self-organized process resulting from the aggregation of workers and their density-dependent digging behavior

  14. Nest enlargement in leaf-cutting ants: relocated brood and fungus trigger the excavation of new chambers.

    Science.gov (United States)

    Römer, Daniela; Roces, Flavio

    2014-01-01

    During colony growth, leaf-cutting ants enlarge their nests by excavating tunnels and chambers housing their fungus gardens and brood. Workers are expected to excavate new nest chambers at locations across the soil profile that offer suitable environmental conditions for brood and fungus rearing. It is an open question whether new chambers are excavated in advance, or will emerge around brood or fungus initially relocated to a suitable site in a previously-excavated tunnel. In the laboratory, we investigated the mechanisms underlying the excavation of new nest chambers in the leaf-cutting ant Acromyrmex lundi. Specifically, we asked whether workers relocate brood and fungus to suitable nest locations, and to what extent the relocated items trigger the excavation of a nest chamber and influence its shape. When brood and fungus were exposed to unfavorable environmental conditions, either low temperatures or low humidity, both were relocated, but ants clearly preferred to relocate the brood first. Workers relocated fungus to places containing brood, demonstrating that subsequent fungus relocation spatially follows the brood deposition. In addition, more ants aggregated at sites containing brood. When presented with a choice between two otherwise identical digging sites, but one containing brood, ants' excavation activity was higher at this site, and the shape of the excavated cavity was more rounded and chamber-like. The presence of fungus also led to the excavation of rounder shapes, with higher excavation activity at the site that also contained brood. We argue that during colony growth, workers preferentially relocate brood to suitable locations along a tunnel, and that relocated brood spatially guides fungus relocation and leads to increased digging activity around them. We suggest that nest chambers are not excavated in advance, but emerge through a self-organized process resulting from the aggregation of workers and their density-dependent digging behavior

  15. Nest enlargement in leaf-cutting ants: relocated brood and fungus trigger the excavation of new chambers.

    Directory of Open Access Journals (Sweden)

    Daniela Römer

    Full Text Available During colony growth, leaf-cutting ants enlarge their nests by excavating tunnels and chambers housing their fungus gardens and brood. Workers are expected to excavate new nest chambers at locations across the soil profile that offer suitable environmental conditions for brood and fungus rearing. It is an open question whether new chambers are excavated in advance, or will emerge around brood or fungus initially relocated to a suitable site in a previously-excavated tunnel. In the laboratory, we investigated the mechanisms underlying the excavation of new nest chambers in the leaf-cutting ant Acromyrmex lundi. Specifically, we asked whether workers relocate brood and fungus to suitable nest locations, and to what extent the relocated items trigger the excavation of a nest chamber and influence its shape. When brood and fungus were exposed to unfavorable environmental conditions, either low temperatures or low humidity, both were relocated, but ants clearly preferred to relocate the brood first. Workers relocated fungus to places containing brood, demonstrating that subsequent fungus relocation spatially follows the brood deposition. In addition, more ants aggregated at sites containing brood. When presented with a choice between two otherwise identical digging sites, but one containing brood, ants' excavation activity was higher at this site, and the shape of the excavated cavity was more rounded and chamber-like. The presence of fungus also led to the excavation of rounder shapes, with higher excavation activity at the site that also contained brood. We argue that during colony growth, workers preferentially relocate brood to suitable locations along a tunnel, and that relocated brood spatially guides fungus relocation and leads to increased digging activity around them. We suggest that nest chambers are not excavated in advance, but emerge through a self-organized process resulting from the aggregation of workers and their density

  16. Interview with Professor Mark Wilcox.

    Science.gov (United States)

    Wilcox, Mark

    2016-08-01

    Mark Wilcox speaks to Georgia Patey, Commissioning Editor: Professor Mark Wilcox is a Consultant Microbiologist and Head of Microbiology at the Leeds Teaching Hospitals (Leeds, UK), the Professor of Medical Microbiology at the University of Leeds (Leeds, UK), and is the Lead on Clostridium difficile and the Head of the UK C. difficile Reference Laboratory for Public Health England (PHE). He was the Director of Infection Prevention (4 years), Infection Control Doctor (8 years) and Clinical Director of Pathology (6 years) at the Leeds Teaching Hospitals. He is Chair of PHE's Rapid Review Panel (reviews utility of infection prevention and control products for National Health Service), Deputy Chair of the UK Department of Health's Antimicrobial Resistance and Healthcare Associated Infection Committee and a member of PHE's HCAI/AR Programme Board. He is a member of UK/European/US working groups on C. difficile infection. He has provided clinical advice as part of the FDA/EMA submissions for the approval of multiple novel antimicrobial agents. He heads a healthcare-associated infection research team at University of Leeds, comprising approximately 30 doctors, scientists and nurses; projects include multiple aspects of C. difficile infection, diagnostics, antimicrobial resistance and the clinical development of new antimicrobial agents. He has authored more than 400 publications, and is the coeditor of Antimicrobial Chemotherapy (5th/6th/7th Editions, 15 December 2007).

  17. Design of Arabic Diacritical Marks

    CERN Document Server

    Hssini, Mohamed

    2011-01-01

    Diacritical marks play a crucial role in meeting the criteria of usability of typographic text, such as: homogeneity, clarity and legibility. To change the diacritic of a letter in a word could completely change its semantic. The situation is very complicated with multilingual text. Indeed, the problem of design becomes more difficult by the presence of diacritics that come from various scripts; they are used for different purposes, and are controlled by various typographic rules. It is quite challenging to adapt rules from one script to another. This paper aims to study the placement and sizing of diacritical marks in Arabic script, with a comparison with the Latin's case. The Arabic script is cursive and runs from right-to-left; its criteria and rules are quite distinct from those of the Latin script. In the beginning, we compare the difficulty of processing diacritics in both scripts. After, we will study the limits of Latin resolution strategies when applied to Arabic. At the end, we propose an approach t...

  18. Detachment of esophageal carcinoma cells from extracellular matrix causes relocalization of death receptor 5 and apoptosis

    Institute of Scientific and Technical Information of China (English)

    Guang-Chao Liu; Jun Zhang; Shi-Gui Liu; Rong Gao; Zhang-Fu Long; Ke Tao; Yuan-Fang Ma

    2009-01-01

    AIM:To investigate the effect of detachment of esophageal cancer cells from extracellular matrix on the localization of death receptor 5 (DR5) and apoptosis.METHODS: Anchorage-dependent EC9706 cells of esophageal squamous cell carcinoma were pretreated or not treated with brefeldin A. Detached cells were harvested by ethylenediaminetetraacetic acid digestion. Expression and localization of DR5 in these cells were determined by immunocytochemical and immunofluorescence assays, as well as flow cytometry analysis. Apoptosis of EC9706 cells was detected by flow cytometry after stained with fluorescein isothiocyanate-labeled annexin V/propidium iodide. Activation of caspase 8 was detected by Western blot analysis.RESULTS: Immunocytochemical assay indicated that DR5 was predominantly perinuclear in adherent cells but was mainly localized in cell membrane in detached cells. In addition, immunofluorescence assay also confirmed the above-mentioned results, and further demonstrated that DR5 was present in the form of coarse granules in detached cells, but in the form of fine granules in adherent cells. Cytometry analysis revealed higher levels of DR5 expression on the surfaces of brefeldin-A-untreated cells than on the surfaces of brefeldin-A-treated cells, but brefeldin A treatment did not affect the total DR5 expression levels. Moreover, nocodazole did not influence the extracelluar DR5 expression levels in EC9706 cells. Apoptosis assay revealed that detached cells were more sensitive to DR5 antibody-induced apoptosis than adherent cells. Western blotting showed that caspase 8 was activated in temporarily detached cells 4 h earlier than in adherent cells.CONCLUSION: Progress from adhesion to detachment of EC9706 cells causes DR5 relocalization, and promotes cytoplasmic translocation of DR5 to cell surfaces via a Golgi-dependent pathway. Moreover, it might also result in DR5 aggregation to render apoptosis of detached cells.

  19. Nest relocation and excavation in the Florida harvester ant, Pogonomyrmex badius.

    Science.gov (United States)

    Tschinkel, Walter R

    2014-01-01

    The Florida harvester ant (Pogonomyrmex badius) excavates deep nests in the sandy soils of the Gulf and Atlantic coastal plains. Nest relocations of over 400 colonies in a north Florida coastal plains pine forest were tracked and mapped from 2010 to 2013. Individual colonies varied from one move in two years to four times a year, averaging about one per year. Almost all moves occurred between May and November peaking in July when more than 1% of the colonies moved per day. Move directions were random, and averaged 4 m, with few moves exceeding 10 m. Distance moved was not related to colony size. Over multiple moves, paths were random walks around the original nest location. Relocation is probably intrinsic to the life history of this species, and the causes of relocation remain obscure--the architecture of old and new nests was very similar, and neither the forest canopy nor the density or size of neighbors was correlated with relocation. Monitoring entire relocations (n = 20) showed that they were usually completed in 4 to 6 days. Moves were diurnal, peaking in the mornings and afternoons dipping during mid-day, and ceasing before sundown. Workers excavated the new nest continuously during the daytime throughout the move and beyond. A minority of workers carried seeds, charcoal and brood, with seeds being by far the most common burden. The proportion of burdened workers increased throughout the move. Measured from year to year, small colonies gained size and large ones lost it. Colonies moving more than once in two years lost more size than those moving less often, suggesting that moving may bear a fitness cost. Colony relocation is a dramatic and consistent feature of the life history of the Florida harvester ant, inviting inquiry into its proximal and ultimate causes.

  20. Nest relocation and excavation in the Florida harvester ant, Pogonomyrmex badius.

    Directory of Open Access Journals (Sweden)

    Walter R Tschinkel

    Full Text Available The Florida harvester ant (Pogonomyrmex badius excavates deep nests in the sandy soils of the Gulf and Atlantic coastal plains. Nest relocations of over 400 colonies in a north Florida coastal plains pine forest were tracked and mapped from 2010 to 2013. Individual colonies varied from one move in two years to four times a year, averaging about one per year. Almost all moves occurred between May and November peaking in July when more than 1% of the colonies moved per day. Move directions were random, and averaged 4 m, with few moves exceeding 10 m. Distance moved was not related to colony size. Over multiple moves, paths were random walks around the original nest location. Relocation is probably intrinsic to the life history of this species, and the causes of relocation remain obscure--the architecture of old and new nests was very similar, and neither the forest canopy nor the density or size of neighbors was correlated with relocation. Monitoring entire relocations (n = 20 showed that they were usually completed in 4 to 6 days. Moves were diurnal, peaking in the mornings and afternoons dipping during mid-day, and ceasing before sundown. Workers excavated the new nest continuously during the daytime throughout the move and beyond. A minority of workers carried seeds, charcoal and brood, with seeds being by far the most common burden. The proportion of burdened workers increased throughout the move. Measured from year to year, small colonies gained size and large ones lost it. Colonies moving more than once in two years lost more size than those moving less often, suggesting that moving may bear a fitness cost. Colony relocation is a dramatic and consistent feature of the life history of the Florida harvester ant, inviting inquiry into its proximal and ultimate causes.

  1. A rapid and automated relocation method of an AFM probe for high-resolution imaging.

    Science.gov (United States)

    Zhou, Peilin; Yu, Haibo; Shi, Jialin; Jiao, Niandong; Wang, Zhidong; Wang, Yuechao; Liu, Lianqing

    2016-09-30

    The atomic force microscope (AFM) is one of the most powerful tools for high-resolution imaging and high-precision positioning for nanomanipulation. The selection of the scanning area of the AFM depends on the use of the optical microscope. However, the resolution of an optical microscope is generally no larger than 200 nm owing to wavelength limitations of visible light. Taking into consideration the two determinants of relocation-relative angular rotation and positional offset between the AFM probe and nano target-it is therefore extremely challenging to precisely relocate the AFM probe to the initial scan/manipulation area for the same nano target after the AFM probe has been replaced, or after the sample has been moved. In this paper, we investigate a rapid automated relocation method for the nano target of an AFM using a coordinate transformation. The relocation process is both simple and rapid; moreover, multiple nano targets can be relocated by only identifying a pair of reference points. It possesses a centimeter-scale location range and nano-scale precision. The main advantages of this method are that it overcomes the limitations associated with the resolution of optical microscopes, and that it is label-free on the target areas, which means that it does not require the use of special artificial markers on the target sample areas. Relocation experiments using nanospheres, DNA, SWCNTs, and nano patterns amply demonstrate the practicality and efficiency of the proposed method, which provides technical support for mass nanomanipulation and detection based on AFM for multiple nano targets that are widely distributed in a large area.

  2. Nest Relocation and Colony Founding in the Australian Desert Ant, Melophorus bagoti Lubbock (Hymenoptera: Formicidae

    Directory of Open Access Journals (Sweden)

    Patrick Schultheiss

    2010-01-01

    Full Text Available Even after years of research on navigation in the Red Honey Ant, Melophorus bagoti, much of its life history remains elusive. Here, we present observations on nest relocation and the reproductive and founding stages of colonies. Nest relocation is possibly aided by trail laying behaviour, which is highly unusual for solitary foraging desert ants. Reproduction occurs in synchronised mating flights, which are probably triggered by rain. Queens may engage in multiple matings, and there is circumstantial evidence that males are chemically attracted to queens. After the mating flight, the queens found new colonies independently and singly. Excavation of these founding colonies reveals first insights into their structure.

  3. Growth Rate and Relocation Movements of Common Nighthawk (Chordeiles minor) Nestlings in Relation to Age

    Science.gov (United States)

    Kramer, Gunnar R.; Chalfoun, Anna D.

    2012-01-01

    Relocation by dependent young is a survival strategy that occurs among a wide range of taxa. The Common Nighthawk (Chordeiles minor) lays its eggs on bare substrate and, once hatched, nestlings may relocate to new sites daily. We located and monitored eight Common Nighthawk nests in Grand Teton National Park, Wyoming, quantified inter-use-site distances in relation to nestling age, and calculated a nestling growth rate curve. Common Nighthawk nestlings grow in a nearly linear fashion. Nestlings moved up to 48 m in a single day and larger, older nestlings tended to move greater distances between daily use-sites.

  4. RELOCATION ALGORITHM FOR NON-UNIFORM DISTRIBUTION IN MOBILE SENSOR NETWORK

    Institute of Scientific and Technical Information of China (English)

    Pei Zhiqiang; Xu Changqing; Teng Jing

    2009-01-01

    Energy is the determinant factor for the survival of Mobile Sensor Networks (MSN). Based on the analysis of the energy distribution in this paper, a two-phase relocation algorithm is proposed based on the balance between the energy provision and energy consumption distribution. Our main objectives are to maximize the coverage percentage and to minimize the total distance of node movements. This algorithm is designed to meet the requirement of non-uniform distribution network applications, to extend the lifetime of MSN and to simplify the design of the routing protocol. In addition, test results show the feasibility of our proposed relocation algorithm.

  5. Classification of delocalization power of global unitary operations in terms of LOCC one-piece relocalization

    Directory of Open Access Journals (Sweden)

    Akihito Soeda

    2010-06-01

    Full Text Available We study how two pieces of localized quantum information can be delocalized across a composite Hilbert space when a global unitary operation is applied. We classify the delocalization power of global unitary operations on quantum information by investigating the possibility of relocalizing one piece of the quantum information without using any global quantum resource. We show that one-piece relocalization is possible if and only if the global unitary operation is local unitary equivalent of a controlled-unitary operation. The delocalization power turns out to reveal different aspect of the non-local properties of global unitary operations characterized by their entangling power.

  6. Relocation and Reestablishment in the City – Case Study of a Displaced Population

    OpenAIRE

    Jaramillo Marin, Jefferson; Universidad Javeriana, Departamento de Sociologia

    2006-01-01

    This article presents a case study of some of the dynamics and social impacts of two different processes of urban relocation. The article analyzes the implications of a temporary relocation process and a definitive establishment of a group of families, victims of forced displacement in the municipality of Tuluá (Valle del Cauca, Colombia). The research discusses the issue related to the urban reestablishment process for people that are victims of displacement and how this process produces rep...

  7. Dialectica Interpretation with Marked Counterexamples

    Directory of Open Access Journals (Sweden)

    Trifon Trifonov

    2011-01-01

    Full Text Available Goedel's functional "Dialectica" interpretation can be used to extract functional programs from non-constructive proofs in arithmetic by employing two sorts of higher-order witnessing terms: positive realisers and negative counterexamples. In the original interpretation decidability of atoms is required to compute the correct counterexample from a set of candidates. When combined with recursion, this choice needs to be made for every step in the extracted program, however, in some special cases the decision on negative witnesses can be calculated only once. We present a variant of the interpretation in which the time complexity of extracted programs can be improved by marking the chosen witness and thus avoiding recomputation. The achieved effect is similar to using an abortive control operator to interpret computational content of non-constructive principles.

  8. Dialectica Interpretation with Marked Counterexamples

    CERN Document Server

    Trifonov, Trifon

    2011-01-01

    Goedel's functional "Dialectica" interpretation can be used to extract functional programs from non-constructive proofs in arithmetic by employing two sorts of higher-order witnessing terms: positive realisers and negative counterexamples. In the original interpretation decidability of atoms is required to compute the correct counterexample from a set of candidates. When combined with recursion, this choice needs to be made for every step in the extracted program, however, in some special cases the decision on negative witnesses can be calculated only once. We present a variant of the interpretation in which the time complexity of extracted programs can be improved by marking the chosen witness and thus avoiding recomputation. The achieved effect is similar to using an abortive control operator to interpret computational content of non-constructive principles.

  9. 78 FR 53477 - Notice of Relocation of the Bureau of Land Management's San Pedro Project Office in Sierra Vista, AZ

    Science.gov (United States)

    2013-08-29

    ... Bureau of Land Management Notice of Relocation of the Bureau of Land Management's San Pedro Project Office in Sierra Vista, AZ AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: This notice announces the relocation of the Bureau of Land Management's (BLM) San Pedro Project Office (SPPO...

  10. Placement, Relocation and End of Life Issues in Aging Adults with and without Down's Syndrome: A Retrospective Study

    Science.gov (United States)

    Patti, P.; Amble, K.; Flory, M.

    2010-01-01

    Background: Aging adults with Down's syndrome (DS) experience more relocations and other life events than adults with intellectual disabilities aged 50 and older without DS. Age-related functional decline and the higher incidence of dementia were implicated as the contributing factors that led to relocation and nursing home placement. Method: A…

  11. 78 FR 38359 - Approval of Record of Decision for Relocation of Cattle Point Road, San Juan Island National...

    Science.gov (United States)

    2013-06-26

    ... National Park Service Approval of Record of Decision for Relocation of Cattle Point Road, San Juan Island... approved a Record of Decision for the Final Environmental Impact Statement for the relocation of the Cattle... Historical Park will begin to implement design and initiate construction of the Cattle Point Road...

  12. Relocations of sea turtle nests of Lepidochelys olivacea, Dermochelys coriacea and Chelonia mydas in the Galibi Nature Reserve, Suriname

    NARCIS (Netherlands)

    Schouten, A.D.; Weijerman, M.; Tienen, van L.H.G.; Hoekert, W.E.J.

    1997-01-01

    SCHOUTEN, A.D., WEIJERMAN, M., VAN TIENEN, L.H.G. & W.E.J. HOEKERT, 1997. Relocations of Sea Turtle nests of Lepidochelys olivacea, Dermochelys coriace and Chelonia mydas in the Galibi Nature Reserve, Suriname. Studies Nat. Hist. Caribbean Region 73, Amsterdam, 1997: 63-69. Relocation of nests of th

  13. Relocations of sea turtle nests of Lepidochelys olivacea, Dermochelys coriacea and Chelonia mydas in the Galibi Nature Reserve, Suriname

    NARCIS (Netherlands)

    Schouten, A.D.; Weijerman, M.; Tienen, van L.H.G.; Hoekert, W.E.J.

    1997-01-01

    SCHOUTEN, A.D., WEIJERMAN, M., VAN TIENEN, L.H.G. & W.E.J. HOEKERT, 1997. Relocations of Sea Turtle nests of Lepidochelys olivacea, Dermochelys coriace and Chelonia mydas in the Galibi Nature Reserve, Suriname. Studies Nat. Hist. Caribbean Region 73, Amsterdam, 1997: 63-69. Relocation of nests of th

  14. Preliminary Analysis on Environmental Impact of Relocation of Cities and Towns in the Three Gorges Reservoir Region%三峡工程库区城镇迁建环境影响初步分析

    Institute of Scientific and Technical Information of China (English)

    XUE; Lian-fang

    2001-01-01

    At the normal pool level of 175 m, the inundated areas of the Three Gor ges Reservoir involve 2 cities, 11 county seats and 140 towns. The population o f the cities and towns under the inundated line totals 393 000 people(1985). The se affected cities and towns will be rebuilt by means of moving back ward to a higher elevation or to other places.The cities and towns to be relocated are the regional political, economic and cu ltural centres, and serve as traffic complexes and places of goods gathering and dist ributing. They are also the seats containing some important cultural re lics and historic sites, landscaping and scenic spots. The relocation of the cit ies and towns will generate far-reaching impacts on regional socio-economy and e nvironment. The unreasonable excavation and fill or the improper protective meas ures adopted may induce land slide,collapse and soil loss. The ruins a nd wastes will affect the water quality in the early period of impoundment of th e Three Gorges Reservoir. A large demand of timber may result in forest fa ll excessively in the local area of the reservoir region, and lower forest and vegetation coverage rate may lead to soil loss. The relocation of the cities an d towns will increase urbanization in reservoir, improve the infrastructure, enh ance their location function and economic radiation capacity. The negative impa ct will r each its maximum during relocation peak period, and the environmental quality wi ll be progressively improved with the recovery of the functions of the relocated cities and towns and the implementation of environmental protection measures. F inally, the negative impact will be offset, and the negative impact will be chan ged into positive environmental elements.

  15. Modelling the duration of residence and plans for future residential relocation: A multilevel analysis

    NARCIS (Netherlands)

    Thomas, Michael J.; Stillwell, John C.H.; Gould, Myles

    2016-01-01

    Among the multitude of studies of factors that determine residential (im)mobility, relatively little attention has been paid to the length of time that people spend in a particular location and the importance of duration of stay for future relocation propensities. This study uses a large and

  16. 41 CFR 302-1.1 - Who is eligible for relocation expense allowances under this chapter?

    Science.gov (United States)

    2010-07-01

    ... to the same or different Government agency. (f) A student trainee assigned to any position upon... prior to relocating); (h) A Department of Defense overseas dependents school system teacher; (i) A... retirement benefits; or (j) An employee that is being assigned to a temporary duty station in connection...

  17. Cultural Diversity, Relocation, and the Security of International Students at an Internationalised University

    Science.gov (United States)

    Forbes-Mewett, Helen; Nyland, Chris

    2008-01-01

    The notion of "security" is an elusive concept that attracts varying interpretations. In this article, the authors adopt a definition that views security as a broadly applicable term that encompasses physical, social, and economic dimensions that relate to human rights, cultural difference, and relocation. The approach embraces the…

  18. 24 CFR 570.210 - Prohibition on use of assistance for employment relocation activities.

    Science.gov (United States)

    2010-04-01

    ... will provide benefit to multiple businesses does not fall under the definition of “directly assist... PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES COMMUNITY... relocation activities. (a) Prohibition. CDBG funds may not be used to directly assist a business, including...

  19. 76 FR 1096 - Pay Under the General Schedule and Recruitment, Relocation, and Retention Incentives

    Science.gov (United States)

    2011-01-07

    ... Recruitment, Relocation, and Retention Incentives AGENCY: U.S. Office of Personnel Management. ACTION... proposed regulations to improve oversight of group recruitment incentive determinations and all retention incentives; add succession planning to the list of factors that an agency may consider before approving a...

  20. Double-Difference Relocation of an Earthquake Nest at Bucaramanga, Colombia: Interaction Between Two Slabs?

    Science.gov (United States)

    Zhang, J.; Waldhauser, F.; Richards, P. G.; Schaff, D. P.

    2007-12-01

    For an earthquake nest at Bucaramanga, Colombia, that has dimensions comparable to the uncertainty of global earthquake bulletins (> 10 km), teleseismic relocation with high precision is achieved by applying a double- difference (DD) algorithm to the pick arrival times from the EHB bulletin of Engdahl et al. (1998) and waveform cross-correlation (WCC) measurements of correlated earthquakes. DD relocations using phase picks alone have relative location uncertainty less than 4 km. They concentrate on a small fault-like volume that has approximate dimensions of 20km x 10km x 10km. A map view of the relocated seismicity shows an elongated structure striking at ~ 135 degree. An on-fault view indicates, on a vertical plane, an approximately 10 km thick band of seismicity, tilting ~ 40 degree to the SE and sub-parallel to the subducting Nazca plate in this area. Further location improvement for 33 correlated events obtained by including WCC measurements in the relocation procedure images a complex near-vertical seismic zone with a width of ~ 5 km. Global CMT solutions for 23 earthquakes within this small volume show highly variable focal mechanisms, independently indicating nonuniform slip within the zone. In general, however, the P axes align with the WSW-orientation of the relative movement between the Nazca and the Caribbean plate. We propose a slab-slab interaction model, in which the nest may represent a contact zone where the two subducting slabs collide and slide past each other.

  1. 77 FR 61632 - Final Environmental Impact Statement for Cattle Point Road Relocation, San Juan Island National...

    Science.gov (United States)

    2012-10-10

    ... National Park Service Final Environmental Impact Statement for Cattle Point Road Relocation, San Juan.... ACTION: Notice of Availability of the Final Environmental Impact Statement for Cattle Point Road... bluff erosion that threatens a segment of the Cattle Point Road located in San Juan Island...

  2. Inter-domain Cooperation in INCENP Promotes Aurora B Relocation from Centromeres to Microtubules

    NARCIS (Netherlands)

    van der Horst, Armando; Vromans, Martijn J M; Bouwman, Kim; van der Waal, Maike S; Hadders, Michael A; Lens, Susanne M A; Lens, SMA

    2015-01-01

    The chromosomal passenger complex is essential for error-free chromosome segregation and proper execution of cytokinesis. To coordinate nuclear division with cytoplasmic division, its enzymatic subunit, Aurora B, relocalizes from centromeres in metaphase to the spindle midzone in anaphase. In buddin

  3. 75 FR 71788 - Agency Requests for Renewal of a Previously Approved Information Collection: Uniform Relocation...

    Science.gov (United States)

    2010-11-24

    ... status from affected persons to establish eligibility for relocation assistance and payments. Displacing agencies will require each person who is to be displaced by a Federal or federally assisted project, as a... displaced person is lawfully present in the United States as required by Public Law 105-117 and 49 CFR...

  4. 24 CFR 582.335 - Displacement, relocation, and real property acquisition.

    Science.gov (United States)

    2010-04-01

    ... CFR 24.2(g)(2); or (iv) HUD determines that the person was not displaced as a direct result of... for displaced persons. A displaced person (defined in paragraph (f) of this section) must be provided... “displaced person,” or the amount of relocation assistance for which the person is eligible, may file...

  5. 24 CFR 574.630 - Displacement, relocation and real property acquisition.

    Science.gov (United States)

    2010-04-01

    ... ineligible under 49 CFR 24.2(g)(2); or (iv) HUD determines that the person was not displaced as a direct... under this part. (b) Relocation assistance for displaced persons. A displaced person (defined in... the requirements described in 49 CFR part 24, subpart B. (d) Appeals. A person who disagrees with...

  6. 24 CFR 511.14 - Tenant assistance, displacement, relocation, and acquisition.

    Science.gov (United States)

    2010-04-01

    ... are described in 49 CFR 24.10. A low-income person that has been displaced from a dwelling may submit... commitment (defined in § 511.2), or earlier. (b) Relocation assistance for displaced persons. A displaced...-administered Small Cities Program) and 24 CFR 570.496a(b) (State CDBG Program). (e) Appeals. If a...

  7. 24 CFR 1000.14 - What relocation and real property acquisition policies are applicable?

    Science.gov (United States)

    2010-04-01

    ... assistance for displaced persons. A displaced person (defined in paragraph (g) of this section) must be....C. 4601-4655) and implementing regulations at 49 CFR part 24. (e) Appeals to the recipient. A person... “displaced person,” or the amount of relocation assistance for which the person is eligible, may file...

  8. 24 CFR 570.606 - Displacement, relocation, acquisition, and replacement of housing.

    Science.gov (United States)

    2010-04-01

    ... occupancy. (C) A person who is not displaced as described in 49 CFR 24.2(g)(2). (D) A person who the grantee... assistance for displaced persons at URA levels. (1) A displaced person shall be provided with relocation... Acquisition Policies Act of 1970 (URA) (42 U.S.C. 4601-4655). (2) Displaced person. (i) For purposes...

  9. Using an ecological ethics framework to make decisions about the relocation of wildlife

    Science.gov (United States)

    McCoy, E.D.; Berry, K.

    2008-01-01

    Relocation is an increasingly prominent conservation tool for a variety of wildlife, but the technique also is controversial, even among conservation practitioners. An organized framework for addressing the moral dilemmas often accompanying conservation actions such as relocation has been lacking. Ecological ethics may provide such a framework and appears to be an important step forward in aiding ecological researchers and biodiversity managers to make difficult moral choices. A specific application of this framework can make the reasoning process more transparent and give more emphasis to the strong sentiments about non-human organisms held by many potential users. Providing an example of the application of the framework may also increase the appeal of the reasoning process to ecological researchers and biodiversity managers. Relocation as a conservation action can be accompanied by a variety of moral dilemmas that reflect the interconnection of values, ethical positions, and conservation decisions. A model that is designed to address moral dilemmas arising from relocation of humans provides/demonstrates/illustrates a possible way to apply the ecological ethics framework and to involve practicing conservationists in the overall decision-making process. ?? 2008 Springer Science+Business Media B.V.

  10. Effects of fuel relocation on reflood in a partially-blocked rod bundle

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Byoung Jae [School of Mechanical Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134 (Korea, Republic of); Kim, Jongrok; Kim, Kihwan; Bae, Sung Won [Thermal-Hydraulic Safety Research Division, Korea Atomic Energy Research Division, 111 Daedeok-daero, Yuseong-gu, Daejeon 34057 (Korea, Republic of); Moon, Sang-Ki, E-mail: skmoon@kaeri.re.kr [Thermal-Hydraulic Safety Research Division, Korea Atomic Energy Research Division, 111 Daedeok-daero, Yuseong-gu, Daejeon 34057 (Korea, Republic of)

    2017-02-15

    Ballooning of the fuel rods has been an important issue, since it can influence the coolability of the rod bundle in a large-break loss-of-coolant accident (LBLOCA). Numerous past studies have investigated the effect of blockage geometry on the heat transfer in a partially blocked rod bundle. However, they did not consider the occurrence of fuel relocation and the corresponding effect on two-phase heat transfer. Some fragmented fuel particles located above the ballooned region may drop into the enlarged volume of the balloon. Accordingly, the fuel relocation brings in a local power increase in the ballooned region. The present study’s objective is to investigate the effect of the fuel relocation on the reflood under a LBLOCA condition. Toward this end, experiments were performed in a 5 × 5 partially-blocked rod bundle. Two power profiles were tested: one is a typical cosine shape and the other is the modified shape considering the effect of the fuel relocation. For a typical power shape, the peak temperature in the ballooned rods was lower than that in the intact rods. On the other hand, for the modified power shape, the peak temperature in the ballooned rods was higher than that in the intact rods. Numerical simulations were also performed using the MARS code. The tendencies of the peak clad temperatures were well predicted.

  11. 24 CFR 1003.209 - Prohibition on use of assistance for employment relocation activities.

    Science.gov (United States)

    2010-04-01

    ... INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMMUNITY DEVELOPMENT BLOCK GRANTS FOR INDIAN... employment relocation activities. (a) Prohibition. ICDBG funds may not be used to directly assist a business... ICDBG funds for activities pursuant to: (i) § 1003.203(b); or (ii) §§ 1003.201(a)-(d), 1003.201(k), 1003...

  12. Nuclear crisis relocation: Issues for a host community-the case of Greenfield, Massachusetts, USA

    Science.gov (United States)

    Platt, Rutherford H.

    1986-03-01

    US civil defense planning for nuclear attack since 1974 has emphasized the doctrine of “crisis relocation.” Under this doctrine, some 150 million people would evacuate from urban areas and other probable targets to rural “host communities.” The population of the latter would “stay put” to assist the relocatees. Local communities would be responsible for the welfare of up to ten times their normal population for an indefinite period of time. This study examined certain implications of crisis relocation for the town of Greenfield, Massachusetts, USA, a typical host community. Various assumptions were articulated regarding the timing of events, the season of year, weather, and social behavior. Assumptions were favorable to the success of crisis relocation. Nevertheless, Greenfield would face impossible burdens in attempting to provide fallout protection, water, food, medical care, and civil order. Additional pressures would arise from adjoining communities which are functionally dependent upon Greenfield for normal goods and services, but which would receive their own allotment of relocatees. Crisis relocation is not taken seriously in Greenfield and virtually no preparations have been made to implement it.

  13. 20 CFR 416.1239 - Exclusion of State or local relocation assistance payments.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Exclusion of State or local relocation assistance payments. 416.1239 Section 416.1239 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Resources and Exclusions § 416.1239 Exclusion...

  14. Surgical relocation of a malpositioned, unserviceable implant protruding into the maxillary sinus cavity. A clinical report.

    Science.gov (United States)

    Stacchi, Claudio; Bonino, Marco; Di Lenarda, Roberto

    2012-08-01

    Malpositioned implants always result in significant mechanical and aesthetic restorative challenges. This case report describes the correction of position of an unserviceable osseointegrated implant also protruding into the maxillary sinus cavity. This surgical technique facilitated the relocation of an implant-bony segment into a more favorable aesthetic and biomechanical position in a single stage surgery.

  15. 33 CFR 146.202 - Notice of arrival or relocation of MODUs on the OCS.

    Science.gov (United States)

    2010-07-01

    ... OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Mobile Offshore Drilling Units § 146.202 Notice of arrival or relocation of MODUs on the OCS. (a) The owner of any mobile... contained in, applications and notices under 33 CFR part 67 for aids to navigation on the Outer...

  16. 76 FR 75450 - Safety Zone; Container Crane Relocation, Cooper and Wando Rivers, Charleston, SC

    Science.gov (United States)

    2011-12-02

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Container Crane Relocation, Cooper and... Guard is establishing a 100 yard temporary moving safety zone around a barge transporting two container..., South Carolina. Discussion of Rule On Monday, December 5, 2011, two container cranes are scheduled to...

  17. Business or Pleasure? Blurring Relocation Categories and Motivation Patterns among Expatriates

    DEFF Research Database (Denmark)

    Lauring, Jakob; Selmer, Jan; Kristian S. Jacobsen, Jens

    2014-01-01

    and relations between leisure tourism and international work relocations. The study uniquely examines demographic differences in tourism and work motivation of academics temporarily residing abroad. Data was collected from 428 self-initiated expatriate academics from 60 countries temporarily working at 34...

  18. Modelling the duration of residence and plans for future residential relocation: A multilevel analysis

    NARCIS (Netherlands)

    Thomas, Michael J.; Stillwell, John C.H.; Gould, Myles

    2016-01-01

    Among the multitude of studies of factors that determine residential (im)mobility, relatively little attention has been paid to the length of time that people spend in a particular location and the importance of duration of stay for future relocation propensities. This study uses a large and detaile

  19. The research of laser marking control technology

    Science.gov (United States)

    Zhang, Qiue; Zhang, Rong

    2009-08-01

    In the area of Laser marking, the general control method is insert control card to computer's mother board, it can not support hot swap, it is difficult to assemble or it. Moreover, the one marking system must to equip one computer. In the system marking, the computer can not to do the other things except to transmit marking digital information. Otherwise it can affect marking precision. Based on traditional control methods existed some problems, introduced marking graphic editing and digital processing by the computer finish, high-speed digital signal processor (DSP) control marking the whole process. The laser marking controller is mainly contain DSP2812, digital memorizer, DAC (digital analog converting) transform unit circuit, USB interface control circuit, man-machine interface circuit, and other logic control circuit. Download the marking information which is processed by computer to U disk, DSP read the information by USB interface on time, then processing it, adopt the DSP inter timer control the marking time sequence, output the scanner control signal by D/A parts. Apply the technology can realize marking offline, thereby reduce the product cost, increase the product efficiency. The system have good effect in actual unit markings, the marking speed is more quickly than PCI control card to 20 percent. It has application value in practicality.

  20. Oleifolioside A mediates caspase-independent human cervical carcinoma HeLa cell apoptosis involving nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG.

    Science.gov (United States)

    Yu, Hai Yang; Jin, Cheng-Yun; Kim, Kyoung-Sook; Lee, Young-Choon; Park, Shin-Hyung; Kim, Gi-Young; Kim, Wun-Jae; Moon, Hyung-In; Choi, Yung Hyun; Lee, Jai-Heon

    2012-05-30

    Apoptosis, the main type of programmed cell death, plays an essential role in a variety of biological events. Whereas "classical" apoptosis is dependent on caspase activation, caspase-independent death is increasingly recognized as an alternative pathway. To develop new anticancer agents, oleifolioside A was isolated from Dendropanax morbifera Leveille and the biochemical mechanisms of oleifolioside A-induced apoptosis in HeLa cells were investigated. Exposure to oleifolioside A resulted in caspase activation and typical features of apoptosis, although cell death was not prevented by caspase inhibition. Oleifolioside A treatment induced up-regulation of Bad, loss of mitochondrial membrane potential, nuclear relocation of mitochondrial factors, apoptosis-inducing factor (AIF), endonuclease G (EndoG), and apoptosis induction. This is the first report of anticancer activity of oleifolioside A, and nuclear translocation of AIF and EndoG in oleifolioside A-treated HeLa cells might represent an alternative death signaling pathway in the absence of caspase activity.

  1. Readers of histone methylarginine marks.

    Science.gov (United States)

    Gayatri, Sitaram; Bedford, Mark T

    2014-08-01

    Arginine methylation is a common posttranslational modification (PTM) that alters roughly 0.5% of all arginine residues in the cells. There are three types of arginine methylation: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA). These three PTMs are enriched on RNA-binding proteins and on histones, and also impact signal transduction cascades. To date, over thirty arginine methylation sites have been cataloged on the different core histones. These modifications alter protein structure, impact interactions with DNA, and also generate docking sites for effector molecules. The primary "readers" of methylarginine marks are Tudor domain-containing proteins. The complete family of thirty-six Tudor domain-containing proteins has yet to be fully characterized, but at least ten bind methyllysine motifs and eight bind methylarginine motifs. In this review, we will highlight the biological roles of the Tudor domains that interact with arginine methylated motifs, and also address other types of interactions that are regulated by these particular PTMs. This article is part of a Special Issue entitled: Molecular mechanisms of histone modification function. Copyright © 2014 Elsevier B.V. All rights reserved.

  2. EDMS - Reaching the Million Mark

    CERN Document Server

    2009-01-01

    When Christophe Seith from the company Cegelec sat down to work on 14 May 2009 at 10:09 a.m. to create the EDMS document entitled "Rapport tournée PH semaine 20", little did he know that he would be the proud creator of the millionth EDMS document and the happy prize winner of a celebratory bottle of champagne to mark the occasion. In the run up to the creation of the millionth EDMS document the EDMS team had been closely monitoring the steady rise in the EDMS number generator, so as to ensure the switch from the six figured i.d. to seven figures would run smoothly and of course, to be able to congratulate the creator of the millionth EDMS document. From left to right: Stephan Petit (GS-ASE- EDS Section Leader), Christophe Delamare (GS- ASE Group Leader), Christophe Seith, creator of the millionth EDMS document, David Widegren, (GS-ASE- EPS Section Leader). The millionth EDMS document. For t...

  3. 46 CFR 160.005-6 - Marking.

    Science.gov (United States)

    2010-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Life Preservers, Fibrous Glass, Adult and Child (Jacket Type), Models 52 and 56 § 160.005-6 Marking. Each life preserver must have the following clearly marked in...

  4. 46 CFR 160.002-6 - Marking.

    Science.gov (United States)

    2010-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Life Preservers, Kapok, Adult and Child (Jacket Type), Models 3 and 5 § 160.002-6 Marking. Each life preserver must have the following clearly marked in waterproof...

  5. On-road Bicycle Pavement Markings

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — A mile by mile breakdown of the on-street bicycle pavement markings installed within the City of Pittsburgh. These include bike lanes, shared lane markings...

  6. Relocation and seismogenic structure of the 1998 Zhangbei-Shangyi earthquake sequence

    Institute of Scientific and Technical Information of China (English)

    杨智娴; 陈运泰; 张宏志

    2002-01-01

    On January 10, 1998, an earthquake of ML=6.2 occurred in the border region between the Zhangbei County and Shangyi County of Hebei Province. This earthquake has been the most significant event occurred in the northern China in the recent years. Historical seismicity in the Zhangbei-Shangyi region was very low. In the epicentral area no active fault capable of generating a moderate earthquake like this event was found. The earthquake locations of the main shock and its aftershocks of the Zhangbei-Shangyi earthquake sequence given by several agencies and authors were diverse and the resulted hypocentral distribution revealed no any dominant horizontal lineation. To study the seismogenic structure of the Zhangbei-Shangyi earthquake, in this paper the main shock and its aftershocks with ML≥3.0 of the Zhangbei-Shangyi earthquake sequence were relocated using the master event relative relocation algorithm. The relocated results show that the epicentral location of the main shock was 41.145°N, 114.462°E, which was located 4 km to the NE of the macro-epicenter of the main shock. The relocated focal depth of the main shock was 15 km. The hypocenters of the aftershocks distributed in a nearly vertical N20°E-striking plane and its vicinity. The relocated results of the Zhangbei-Shangyi earthquake sequence clearly indicated that the seismogenic structure of this event was a nearly N-S- to NNE-SSW-striking fault with right-lateral and reverse slip, and that the occurrence of this event was associated with the horizontal and ENE-oriented compressive tectonic stress, which was compatible with the tectonic stress field in the northern China.

  7. New Hypocenter Relocation Results From Volcano-Tectonic Events (1995-2006) at Popocatepetl Volcano, Mexico

    Science.gov (United States)

    Berger, P.; Nava, F. A.; Valdes-Gonzalez, C.

    2008-12-01

    Popocatepetl, one of the most active strato-volcanoes in Mexico, started a fumarolic and seismic reactivation in December 1994. New hypocenter relocation results have been calculated for some 1,800 volcano-tectonic (VT) events recorded by the seismic network operating at Popocatepetl during 1995-2006, and previously located by the National Center for Disasters Prevention (CENAPRED). We used two location programs to determine hypocenter relocation. One is a recently developed genetic algorithm program, Disloca, which adjusts the differences in arrival times between the recording seismic stations. The second is HypoDD, which uses the double difference earthquake location algorithm. Disloca allowed evaluation of station corrections, plus location of non-clustered hypocenters, while HypoDD refined the locations of clustered ones. Thus, for a given velocity model, hypocenters of clustered events varied slightly depending on the location program. For both programs, four different crustal velocity models were used, two of which include a low velocity zone (LVZ) below 6 km depth. This LVZ represents the presence of magma, which has been suggested to exist at this depth. The spatial distribution of the relocated hypocenters varies from one model to another, but a carefully considered combination of features common to the four distributions, allows a new characterization of the VT activity at Popocatepetl. The distribution of the relocated hypocenters found in this study differs from that of former investigations at Popocatépetl, and gives new insights into the volcano's structures. Hypocenters occur mainly above 10 km depth, with a horizontal range of about 5 km. Features of the spatial distribution allow a tentative interpretation of several internal volcanic structures. Chief among these are branched dike complexes and different sized zones free of volcano-tectonic events, which are in turn surrounded by zones of magma-rock interaction, as indicated by the presence of

  8. A rapid and automated relocation method of an AFM probe for high-resolution imaging

    Science.gov (United States)

    Zhou, Peilin; Yu, Haibo; Shi, Jialin; Jiao, Niandong; Wang, Zhidong; Wang, Yuechao; Liu, Lianqing

    2016-09-01

    The atomic force microscope (AFM) is one of the most powerful tools for high-resolution imaging and high-precision positioning for nanomanipulation. The selection of the scanning area of the AFM depends on the use of the optical microscope. However, the resolution of an optical microscope is generally no larger than 200 nm owing to wavelength limitations of visible light. Taking into consideration the two determinants of relocation—relative angular rotation and positional offset between the AFM probe and nano target—it is therefore extremely challenging to precisely relocate the AFM probe to the initial scan/manipulation area for the same nano target after the AFM probe has been replaced, or after the sample has been moved. In this paper, we investigate a rapid automated relocation method for the nano target of an AFM using a coordinate transformation. The relocation process is both simple and rapid; moreover, multiple nano targets can be relocated by only identifying a pair of reference points. It possesses a centimeter-scale location range and nano-scale precision. The main advantages of this method are that it overcomes the limitations associated with the resolution of optical microscopes, and that it is label-free on the target areas, which means that it does not require the use of special artificial markers on the target sample areas. Relocation experiments using nanospheres, DNA, SWCNTs, and nano patterns amply demonstrate the practicality and efficiency of the proposed method, which provides technical support for mass nanomanipulation and detection based on AFM for multiple nano targets that are widely distributed in a large area.

  9. Relocation of hypocenters from DOMERAPI and BMKG networks: a preliminary result from DOMERAPI project

    Science.gov (United States)

    Ramdhan, Mohamad; Widiyantoro, Sri; Nugraha, Andri Dian; Métaxian, Jean-Philippe; Saepuloh, Asep; Kristyawan, Said; Sembiring, Andry Syaly; Santoso, Agus Budi; Laurin, Antoine; Fahmi, Ahmad Ali

    2017-04-01

    Merapi volcano located in central Java, Indonesia, is one of the most active stratovolcanoes in the world. Many Earth scientists have conducted studies on this volcano using various methods. The geological features around Merapi are very attractive to be investigated because they have been formed by a complex tectonic process and volcanic activities since tens of millions of years ago. The southern mountain range, Kendeng basin and Opak active fault located around the study area resulted from these processes. DOMERAPI project was conducted to understand deep magma sources of the Merapi volcano comprehensively. The DOMERAPI network was running from October 2013 to mid-April 2015 by deploying 46 broad-band seismometers around the volcano. Several steps, i.e., earthquake event identification, arrival time picking of P and S waves, hypocenter determination and hypocenter relocation, were carried out in this study. We used Geiger's method (Geiger 1912) for hypocenter determination and double-difference method for hypocenter relocation. The relocation result will be used to carry out seismic tomographic imaging of structures beneath the Merapi volcano and its surroundings. For the hypocenter determination, the DOMERAPI data were processed simultaneously with those from the Agency for Meteorology, Climatology and Geophysics (BMKG) seismic network in order to minimize the azimuthal gap. We found that the majority of earthquakes occurred outside the DOMERAPI network. There are 464 and 399 earthquakes obtained before and after hypocenter relocation, respectively. The hypocenter relocation result successfully detects some tectonic features, such as a nearly vertical cluster of events indicating a subduction-related backthrust to the south of central Java and a cluster of events to the east of Opak fault suggesting that the fault has an eastward dip.

  10. 19 CFR 18.27 - Port marks.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Port marks. 18.27 Section 18.27 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY TRANSPORTATION... Port marks. Port marks may be added by authority of the port director and under the supervision of...

  11. 27 CFR 28.123 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.123..., or Transportation to a Manufacturing Bonded Warehouse § 28.123 Export marks. (a) General. In addition... filled under the provisions of part 24 of this chapter, the proprietor shall mark the word “Export” on...

  12. 27 CFR 28.216 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.216... Export marks. In addition to the marks and brands required to be placed on packages or other bulk... “Export” on the Government side of each case or Government head of each container before removal for...

  13. 27 CFR 28.223 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.223... Export marks. In addition to the marks and brands required to be placed on kegs, barrels, cases, crates... “Export” on each container or case before removal for export, for use on vessels or aircraft, or for...

  14. A viral nuclear noncoding RNA binds re-localized poly(A binding protein and is required for late KSHV gene expression.

    Directory of Open Access Journals (Sweden)

    Sumit Borah

    2011-10-01

    Full Text Available During the lytic phase of infection, the gamma herpesvirus Kaposi's Sarcoma-Associated Herpesvirus (KSHV expresses a highly abundant, 1.1 kb nuclear noncoding RNA of unknown function. We observe that this polyadenylated nuclear (PAN RNA avidly binds host poly(A-binding protein C1 (PABPC1, which normally functions in the cytoplasm to bind the poly(A tails of mRNAs, regulating mRNA stability and translation efficiency. During the lytic phase of KSHV infection, PABPC1 is re-localized to the nucleus as a consequence of expression of the viral shutoff exonuclease (SOX protein; SOX also mediates the host shutoff effect in which host mRNAs are downregulated while viral mRNAs are selectively expressed. We show that whereas PAN RNA is not required for the host shutoff effect or for PABPC1 re-localization, SOX strongly upregulates the levels of PAN RNA in transient transfection experiments. This upregulation is destroyed by the same SOX mutation that ablates the host shutoff effect and PABPC1 nuclear re-localization or by removal of the poly(A tail of PAN. In cells induced into the KSHV lytic phase, depletion of PAN RNA using RNase H-targeting antisense oligonucleotides reveals that it is necessary for the production of late viral proteins from mRNAs that are themselves polyadenylated. Our results add to the repertoire of functions ascribed to long noncoding RNAs and suggest a mechanism of action for nuclear noncoding RNAs in gamma herpesvirus infection.

  15. Demography and movement in a relocated population of Oregon Spotted Frogs (Rana pretiosa): Influence of season and gender

    Science.gov (United States)

    Chelgren, N.D.; Pearl, C.A.; Adams, M.J.; Bowerman, J.

    2008-01-01

    We used five years of recapture data and Bayesian estimation to assess seasonal survival, movement, and growth of Oregon Spotted Frogs (Rana pretiosa) relocated into created ponds at Dilman Meadow in Oregon, USA. We evaluate hypotheses specific to the relocation and elucidate aspects of R. pretiosa life history that are poorly known. The odds of survival of relocated individuals during the first year following relocation were 0.36 times the survival odds of relocated and non-relocated frogs after one year since the relocation. Survival rate was higher for large frogs. After accounting for frog size, we found little variation in survival between ponds at Dilman Meadow. Survival was lowest for males during the breeding/post-breeding redistribution period, suggesting a high cost of breeding for males. The highest survival rates occurred during winter for both genders, and one small spring was used heavily during winter but was used rarely during the rest of the year. Individual growth was higher in ponds that were not used for breeding, and increased with increasing pond age. Our study supports other evidence that R. pretiosa use different habitats seasonally and are specific in their overwintering habitat requirements. Because frogs were concentrated during winter, predator-free overwintering springs are likely to be of particular value for R. pretiosa populations. ?? 2008 by the American Society of Ichthyologists and Herpetologists.

  16. Clues to the signals for chloroplast photo-relocation from the lifetimes of accumulation and avoidance responses

    Institute of Scientific and Technical Information of China (English)

    Takeshi Higa; Masamitsu Wada

    2015-01-01

    Chloroplast photo-relocation movement is crucial for plant survival;however, the mechanism of this phenome-non is stil poorly understood. Especial y, the signal that goes from photoreceptor to chloroplast is unknown, although the photoreceptors (phototropin 1 and 2) have been identified and an actin structure (chloroplast actin filaments) has been characterized that is specific for chloroplast movement. Here, in gametophytes of the fern Adiantum capillus-veneris, gametophores of the moss Physcomiterella patens, and leaves of the seed plant Arabidopsis thaliana, we sought to characterize the signaling system by measuring the lifetime of the induced response. Chloroplast movements were induced by microbeam irradiation with high-intensity blue light and recorded. The lifetime of the avoidance state was measured as a lag time between switching off the beam and the loss of avoidance behavior, and that of the accumulation state was measured as the duration of accumulation behavior fol owing the extinction of the beam. The lifetime for the avoidance response state is approximately 3–4 min and that for the accumulation response is 19–28 min. These data suggest that the two responses are based on distinct signals.

  17. Clues to the signals for chloroplast photo-relocation from the lifetimes of accumulation and avoidance responses.

    Science.gov (United States)

    Higa, Takeshi; Wada, Masamitsu

    2015-01-01

    Chloroplast photo-relocation movement is crucial for plant survival; however, the mechanism of this phenomenon is still poorly understood. Especially, the signal that goes from photoreceptor to chloroplast is unknown, although the photoreceptors (phototropin 1 and 2) have been identified and an actin structure (chloroplast actin filaments) has been characterized that is specific for chloroplast movement. Here, in gametophytes of the fern Adiantum capillus-veneris, gametophores of the moss Physcomiterella patens, and leaves of the seed plant Arabidopsis thaliana, we sought to characterize the signaling system by measuring the lifetime of the induced response. Chloroplast movements were induced by microbeam irradiation with high-intensity blue light and recorded. The lifetime of the avoidance state was measured as a lag time between switching off the beam and the loss of avoidance behavior, and that of the accumulation state was measured as the duration of accumulation behavior following the extinction of the beam. The lifetime for the avoidance response state is approximately 3-4 min and that for the accumulation response is 19-28 min. These data suggest that the two responses are based on distinct signals.

  18. Evidence of a genetic instability induced by the incorporation of a DNA precursor marked with tritium; Mise en evidence d'une instabilite genetique induite par l'incorporation d'un precurseur de L'ADN marque au tritium

    Energy Technology Data Exchange (ETDEWEB)

    Saintigny, Y.; Laurent, D.; Lahayel, J.B. [CEA Fontenay-aux-Roses, IRCM-LRTS, U967 - CEA/INSERM/Universites Paris 7 and Paris-11, 92 (France); Roche, St.; Meynard, D.; Lopez, B.S. [CEA Fontenay-aux-Roses, LMR - UMR 217 - CEA/CNRS, Institut de Radiobiologie Cellulaire et moleculaire, Direction des Sciences du Vivant, 92 (France)

    2009-07-01

    The authors report a molecular geno-toxicology investigation which allowed molecular events induced par intracellular incorporation of tritium to be studied, and the genetic instability resulting from a chronic exposure even at low dose to be analysed. For this purpose, they developed cell models (hamster tumorous cells and human fibroblasts) in which they know how to incorporate given quantities of marked nucleotides in the DNA. They show that the incorporation of tritium, even with doses which are said to be non toxic, causes a prolonged exposure of the cell to a genotoxic stress, and maybe a genetic instability due to a too great number of recombination events

  19. Regulation of glucose homeostasis by KSR1 and MARK2.

    Directory of Open Access Journals (Sweden)

    Paula J Klutho

    Full Text Available Protein scaffolds control the intensity and duration of signaling and dictate the specificity of signaling through MAP kinase pathways. KSR1 is a molecular scaffold of the Raf/MEK/ERK MAP kinase cascade that regulates the intensity and duration of ERK activation. Relative to wild-type mice, ksr1⁻/⁻ mice are modestly glucose intolerant, but show a normal response to exogenous insulin. However, ksr1⁻/⁻ mice also demonstrate a three-fold increase in serum insulin levels in response to a glucose challenge, suggesting a role for KSR1 in insulin secretion. The kinase MARK2 is closely related to C-TAK1, a known regulator of KSR1. Mice lacking MARK2 have an increased rate of glucose disposal in response to exogenous insulin, increased glucose tolerance, and are resistant to diet-induced obesity. mark2⁻/⁻ksr1⁻/⁻ (DKO mice were compared to wild type, mark2⁻/⁻, and ksr1⁻/⁻ mice for their ability to regulate glucose homeostasis. Here we show that disruption of KSR1 in mark2⁻/⁻ mice reverses the increased sensitivity to exogenous insulin resulting from MARK2 deletion. DKO mice respond to exogenous insulin similarly to wild type and ksr1⁻/⁻ mice. These data suggest a model whereby MARK2 negatively regulates insulin sensitivity in peripheral tissue through inhibition of KSR1. Consistent with this model, we found that MARK2 binds and phosphorylates KSR1 on Ser392. Phosphorylation of Ser392 is a critical regulator of KSR1 stability, subcellular location, and ERK activation. These data reveal an unexpected role for the molecular scaffold KSR1 in insulin-regulated glucose metabolism.

  20. Aerial tracking of radio-marked white-tailed tropicbirds over the Caribbean Sea

    Science.gov (United States)

    Fuller, M.R.; Obrecht, H.H.; Pennycuick, C.J.; Schaffner, F.C.; Amlaner, Charles J.

    1989-01-01

    We radio-marked nesting white-tailed tropicbirds at Culebra National Wildlife Refuge, Puerto Rico, and tracked them from a Cessna 182 during flights over the open sea. Locations of the birds were determined using standard aerial telemetry techniques for side-facing Yagi antennas. We used strut-mounted, 4-element Yagi antennas connected to a switchbox and scanning receiver. By recording bearing and distance from at least 1 of 3 aeronautical navigation beacons, the position of the aircraft and the bird could be estimated with an error of about 2 km. On several occasions we plotted the general heading of a bird and then relocated and tracked the same bird on the following day. Our method of aerial tracking and navigation was useful for tracking birds over the sea to at least 116 km from the breeding colony

  1. Preliminary results of teleseismic double-difference relocation of earthquakes around Indonesian archipelago region

    Energy Technology Data Exchange (ETDEWEB)

    Nugraha, Andri Dian, E-mail: andridn104@gmail.com; Widiyantoro, Sri [Global Geophysical Research Group, Faculty of Mining and Petroleum Engineering, Institut Teknologi Bandung (Indonesia); Shiddiqi, Hasbi Ash [Earth Sciences Graduate Program, Faculty of Earth Sciences and Technology, Institut Teknologi Bandung (Indonesia); Ramdhan, Mohamad; Wandono,; Sutiyono,; Handayani, Titi; Nugroho, Hendro [Agency for Meteorology, Climatology, and Geophysics (BMKG), Jakarta (Indonesia)

    2015-04-24

    Indonesian archipelago region is located in active tectonic setting and high seismicity zone. During the last decade, Indonesian was experienced with destructive major earthquakes causing damage and victims. The information of precise earthquake location parameters are very important in partular for earthquake early warning to the society and for advance seismic studies. In this study, we attempted to improve hypocenter location compiled by BMKG for time periods of April, 2009 up to June, 2014 for about 22,000 earthquake events around Indonesian region. For the firts time, we applied teleseismic double-difference relocation algorithm (teletomoDD) to improve hypocenter region in Indonesia region combining regional and teleseismic stations. Hypocenter relocation was performed utilizing local, regional, and teleseismic P-wave arrival time data. Our relocation result show that travel-time RMS errors were greatly reduced compared to the BMKG catalog. Seismicity at shallower depth (less than 50 km) shows significantly improvement especially in depth, and refined shallow geological structures, e.g. trench and major strike slip faults. Clustered seismicity is also detected beneath volcanic region, and probably related volcano activities and also major faults nearby. In the Sunda arc region, seismicity at shallower depth centered at two major distributions parallel to the trench strike direction, i.e. around fore-arc and in mainland that related to major fault, e.g. the Sumatran fault, and volcanic fronts. Below Central Java region, relocated hypocenter result showed double seismic zone pattern. A seismic gap is detected around the Sunda-Banda transition zone where transition between oceanic subduction to continental crust collision of Australian plate occurs. In Eastern Indonesia region, shallow earthquakes are observed related to major strike slip faults, e.g. Sorong and Palu-Koro fault, volcanism, and shallow part of subduction and collision zones. We also compare our

  2. Preliminary results of teleseismic double-difference relocation of earthquakes around Indonesian archipelago region

    Science.gov (United States)

    Nugraha, Andri Dian; Shiddiqi, Hasbi Ash; Widiyantoro, Sri; Ramdhan, Mohamad; Wandono, Sutiyono, Handayani, Titi; Nugroho, Hendro

    2015-04-01

    Indonesian archipelago region is located in active tectonic setting and high seismicity zone. During the last decade, Indonesian was experienced with destructive major earthquakes causing damage and victims. The information of precise earthquake location parameters are very important in partular for earthquake early warning to the society and for advance seismic studies. In this study, we attempted to improve hypocenter location compiled by BMKG for time periods of April, 2009 up to June, 2014 for about 22,000 earthquake events around Indonesian region. For the firts time, we applied teleseismic double-difference relocation algorithm (teletomoDD) to improve hypocenter region in Indonesia region combining regional and teleseismic stations. Hypocenter relocation was performed utilizing local, regional, and teleseismic P-wave arrival time data. Our relocation result show that travel-time RMS errors were greatly reduced compared to the BMKG catalog. Seismicity at shallower depth (less than 50 km) shows significantly improvement especially in depth, and refined shallow geological structures, e.g. trench and major strike slip faults. Clustered seismicity is also detected beneath volcanic region, and probably related volcano activities and also major faults nearby. In the Sunda arc region, seismicity at shallower depth centered at two major distributions parallel to the trench strike direction, i.e. around fore-arc and in mainland that related to major fault, e.g. the Sumatran fault, and volcanic fronts. Below Central Java region, relocated hypocenter result showed double seismic zone pattern. A seismic gap is detected around the Sunda-Banda transition zone where transition between oceanic subduction to continental crust collision of Australian plate occurs. In Eastern Indonesia region, shallow earthquakes are observed related to major strike slip faults, e.g. Sorong and Palu-Koro fault, volcanism, and shallow part of subduction and collision zones. We also compare our

  3. A tailored relocation stress intervention programme for family caregivers of patients transferred from a surgical intensive care unit to a general ward.

    Science.gov (United States)

    Lee, Seul; Oh, HyunSoo; Suh, YeonOk; Seo, WhaSook

    2017-03-01

    To develop and examine a relocation stress intervention programme tailored for the family caregivers of patients scheduled for transfer from a surgical intensive care unit to a general ward. Family relocation stress syndrome has been reported to be similar to that exhibited by patients, and investigators have emphasised that nurses should make special efforts to relieve family relocation stress to maximise positive contributions to the well-being of patients by family caregivers. A nonequivalent control group, nonsynchronised pretest-post-test design was adopted. The study subjects were 60 family caregivers of patients with neurosurgical or general surgical conditions in the surgical intensive care unit of a university hospital located in Incheon, South Korea. Relocation stress and family burden were evaluated at three times, that is before intervention, immediately after transfer and four to five days after transfer. This relocation stress intervention programme was developed for the family caregivers based on disease characteristics and relocation-related needs. In the experimental group, relocation stress levels significantly and continuously decreased after intervention, whereas in the control group, a slight nonsignificant trend was observed. Family burden levels in the control group increased significantly after transfer, whereas burden levels in the experimental group increased only marginally and nonsignificantly. No significant between-group differences in relocation stress or family burden levels were observed after intervention. Relocation stress levels of family caregivers were significantly decreased after intervention in the experimental group, which indicates that the devised family relocation stress intervention programme effectively alleviated family relocation stress. The devised intervention programme, which was tailored to disease characteristics and relocation-related needs, may enhance the practicality and efficacy of relocation stress

  4. Earthquake hypocenter relocation using double difference method in East Java and surrounding areas

    Science.gov (United States)

    C, Aprilia Puspita; Nugraha, Andri Dian; Puspito, Nanang T.

    2015-04-01

    Determination of precise hypocenter location is very important in order to provide information about subsurface fault plane and for seismic hazard analysis. In this study, we have relocated hypocenter earthquakes in Eastern part of Java and surrounding areas from local earthquake data catalog compiled by Meteorological, Climatological, and Geophysical Agency of Indonesia (MCGA) in time period 2009-2012 by using the double-difference method. The results show that after relocation processes, there are significantly changes in position and orientation of earthquake hypocenter which is correlated with the geological setting in this region. We observed indication of double seismic zone at depths of 70-120 km within the subducting slab in south of eastern part of Java region. Our results will provide useful information for advance seismological studies and seismic hazard analysis in this study.

  5. 1-D seismic velocity model and hypocenter relocation using double difference method around West Papua region

    Science.gov (United States)

    Sabtaji, Agung; Nugraha, Andri Dian

    2015-04-01

    West Papua region has fairly high of seismicity activities due to tectonic setting and many inland faults. In addition, the region has a unique and complex tectonic conditions and this situation lead to high potency of seismic hazard in the region. The precise earthquake hypocenter location is very important, which could provide high quality of earthquake parameter information and the subsurface structure in this region to the society. We conducted 1-D P-wave velocity using earthquake data catalog from BMKG for April, 2009 up to March, 2014 around West Papua region. The obtained 1-D seismic velocity then was used as input for improving hypocenter location using double-difference method. The relocated hypocenter location shows fairly clearly the pattern of intraslab earthquake beneath New Guinea Trench (NGT). The relocated hypocenters related to the inland fault are also observed more focus in location around the fault.

  6. Earthquake hypocenter relocation using double difference method in East Java and surrounding areas

    Energy Technology Data Exchange (ETDEWEB)

    C, Aprilia Puspita [Geophysical Engineering Program, Faculty of Mining and Petroleum Engineering, Institute of Technology Bandung (Indonesia); Meteorological, Climatological, and Geophysical Agency (MCGA) of Indonesian, Jakarta (Indonesia); Nugraha, Andri Dian, E-mail: nugraha@gf.itb.ac.id [Geophysical Engineering Program, Faculty of Mining and Petroleum Engineering, Institute of Technology Bandung (Indonesia); Puspito, Nanang T [Global Geophysical Research Group, Faculty of Mining and Petroleum Engineering, Institute of Technology Bandung (Indonesia)

    2015-04-24

    Determination of precise hypocenter location is very important in order to provide information about subsurface fault plane and for seismic hazard analysis. In this study, we have relocated hypocenter earthquakes in Eastern part of Java and surrounding areas from local earthquake data catalog compiled by Meteorological, Climatological, and Geophysical Agency of Indonesia (MCGA) in time period 2009-2012 by using the double-difference method. The results show that after relocation processes, there are significantly changes in position and orientation of earthquake hypocenter which is correlated with the geological setting in this region. We observed indication of double seismic zone at depths of 70-120 km within the subducting slab in south of eastern part of Java region. Our results will provide useful information for advance seismological studies and seismic hazard analysis in this study.

  7. The Impact of DEM Resolution on Relocating Radar Altimetry Data Over Ice Sheets

    DEFF Research Database (Denmark)

    Fredenslund Levinsen, Joanna; Simonsen, Sebastian Bjerregaard; Sørensen, Louise Sandberg

    2016-01-01

    for correcting for such mispointing errors. Here, two techniques are applied to observations near Jakobshavn Isbræ, acquired with Envisat’s Radar Altimeter(RA-2). The apriori knowledge on the surface topography is obtained from a digital elevation model. The methods relocate the measurement location horizontally......Beam-limited footprints from conventional satellite radar altimeters have diameters of up to tens of kilometers. Topography within the footprint results in a displacement of the reflecting point from Nadir to the point of closest approach relative to the satellite. Several methods exist...... to agree with the measured range. One method assumes a constant surface slope within the footprint and uses this and the surface aspect to estimate the displacement parameter; the other locates the optimal relocation point using local topography. The results of the two methods are evaluated against...

  8. Relocation of Business Services into Central and Eastern Europe (Evidence from Trade and Location Statistics

    Directory of Open Access Journals (Sweden)

    ZOLTÁN GÁL

    2014-06-01

    Full Text Available Relocation of business service offshoring-related activities measured by foreign direct investments and exports in services have grown rapidly after the Millennium in the new EU member states of Central and Eastern Europe (CEE. Besides Foreign Direct Investment (FDI, trade statistics support the assumption that an expanding export in business and in ICT services has been associated with relocation of shared services centres created by FDI in the six new member states (NMS. The service export data collected between 1996/2002 and 2012 gives a good proxy to identify those segments of service trade, which are considered to be offshorable. The paper examines the additional location factors selecting Central and Eastern European locations and summarises the effect of crisis on this industry. It concludes that the sector has demonstrated market resilience in the NMS and continued to expand rapidly.

  9. Business closure and relocation: a comparative analysis of the Loma Prieta earthquake and Hurricane Andrew.

    Science.gov (United States)

    Wasileski, Gabriela; Rodríguez, Havidán; Diaz, Walter

    2011-01-01

    The occurrence of a number of large-scale disasters or catastrophes in recent years, including the Indian Ocean tsunami (2004), the Kashmir earthquake (2005), Hurricane Katrina (2005) and Hurricane Ike (2008), have raised our awareness regarding the devastating effects of disasters on human populations and the importance of developing mitigation and preparedness strategies to limit the consequences of such events. However, there is still a dearth of social science research focusing on the socio-economic impact of disasters on businesses in the United States. This paper contributes to this research literature by focusing on the impact of disasters on business closure and relocation through the use of multivariate logistic regression models, specifically focusing on the Loma Prieta earthquake (1989) and Hurricane Andrew (1992). Using a multivariate model, we examine how physical damage to the infrastructure, lifeline disruption and business characteristics, among others, impact business closure and relocation following major disasters.

  10. Vertical Handoff In Wlan-Wimax-Lte Heterogeneous Networks Through Gateway Relocation

    Directory of Open Access Journals (Sweden)

    L. Nithyanandan

    2012-09-01

    Full Text Available In wireless communication new technologies emerges regularly with faster data rates and larger coverage area. Therefore the forthcoming challenge is to make the best possible use of the available heterogeneous network. For connecting mobile between heterogeneous networks vertical handoff is mandatory. IP Multimedia Subsystem is an emerging architecture for interworking of heterogeneous networks. In this paper we used WLAN/WiMAX/LTE heterogeneous networks. Coupling architectures such as tight coupling and loose coupling are considered. In order to reduce the latency two mechanisms such as neighbour bandwidth reservation and gateway relocation are employed. The parameters such as vertical handoff delay, Mobile scanning interval activity, neighbouring advertisement received are obtained. From the simulation it is inferred that tight coupling with gateway relocation is performingbetter from handover point of view.

  11. Relocation of children after divorce and children's best interests: new evidence and legal considerations.

    Science.gov (United States)

    Braver, Sanford L; Ellman, Ira M; Fabricius, William V

    2003-06-01

    Relocation cases, in which a divorced parent seeks to move away with the child, are among the knottiest problems facing family courts. The recent trend is to permit such moves, largely because of Wallerstein's (1995) controversial amica curiae brief, which a recent court (Baures v. Lewis, 2001) interpreted as supporting the conclusion that "in general, what is good for the custodial parent is good for the child" (p. 222). The current study provides the first direct evidence on relocation by dividing college students into groups on the basis of their divorced parents' move-away status. On most child outcomes, the ones whose parents moved are significantly disadvantaged. This suggests courts should give greater weight to the child's separate interests in deciding such cases.

  12. 1-D seismic velocity model and hypocenter relocation using double difference method around West Papua region

    Energy Technology Data Exchange (ETDEWEB)

    Sabtaji, Agung, E-mail: sabtaji.agung@gmail.com, E-mail: agung.sabtaji@bmkg.go.id [Study Program of Earth Sciences, Faculty of Earth Sciencies and Technology, Institute of Technology Bandung, Bandung 40132 (Indonesia); Indonesia’s Agency for Meteorological, Climatological and Geophysics Region V, Jayapura 1572 (Indonesia); Nugraha, Andri Dian, E-mail: nugraha@gf.itb.ac.id [Global Geophysics Research Group, Faculty of Mining and Petroleum Engineering, Institute of Technology Bandung, Bandung 40132 (Indonesia)

    2015-04-24

    West Papua region has fairly high of seismicity activities due to tectonic setting and many inland faults. In addition, the region has a unique and complex tectonic conditions and this situation lead to high potency of seismic hazard in the region. The precise earthquake hypocenter location is very important, which could provide high quality of earthquake parameter information and the subsurface structure in this region to the society. We conducted 1-D P-wave velocity using earthquake data catalog from BMKG for April, 2009 up to March, 2014 around West Papua region. The obtained 1-D seismic velocity then was used as input for improving hypocenter location using double-difference method. The relocated hypocenter location shows fairly clearly the pattern of intraslab earthquake beneath New Guinea Trench (NGT). The relocated hypocenters related to the inland fault are also observed more focus in location around the fault.

  13. Aluminum alloy nanosecond vs femtosecond laser marking

    Indian Academy of Sciences (India)

    S Rusu; A Buzaianu; D G Galusca; L Ionel; D Ursescu

    2013-11-01

    Based on the lack of consistent literature publications that analyse the effects of laser marking for traceability on various materials, the present paper proposes a study of the influence of such radiation processing on an aluminum alloy, a vastly used material base within several industry fields. For the novelty impact, femtolaser marking has been carried out, besides the standard commercial nanosecond engraving. All the marks have been analysed using profilometry, overhead and cross-section SEM microscopy, respectively and EDAX measurements.

  14. Geometry of the Subducting Nazca Plate Beneath Colombia From Relocation of Intermediate-Depth Earthquakes

    Science.gov (United States)

    Chang, Y.; Warren, L. M.; Prieto, G. A.; Grigsby, I.

    2013-12-01

    In subduction zones, earthquakes help distinguish the location of the downgoing slab to hundreds of kilometers depth. However, beneath northwestern South America, the distribution of large intermediate-depth earthquakes in the Global CMT catalog has gaps along the subduction zone, so the position of the subducting Nazca plate is uncertain. In addition, the earthquake focal mechanisms, which range from along-strike compression to down-dip extension, vary over short distances, suggesting that the subducting slab may have a complicated morphology. To clarify the geometry of the subducting Nazca plate beneath Colombia, we relocate regional seismicity recorded by the Colombian National Seismic Network (RSNC). Our data set contains 1231 earthquakes with catalog locations from 0°N-6°N and 72°W-81°W at depths of 0-200 km and magnitudes from M2.5-6.5 that occurred between 1/2010-2/2013. Catalog hypocenters show an ~20 km thick slab subducting to the east, as well as vertical columns extending up from the slab. The shape, thickness, and position of the slab and other features can be refined by using differential travel times to relocate the earthquakes relative to each other. We verify and adjust the network P and S wave picks and pick arrivals at additional or temporary stations, and these arrival times are used to relocate the earthquakes. The hypocenters of the relocated earthquakes are used to generate 3D contours of the subducting plate and visualize bends and folds in the slab.

  15. The modeling of core melting and in-vessel corium relocation in the APRIL code

    Energy Technology Data Exchange (ETDEWEB)

    Kim. S.W.; Podowski, M.Z.; Lahey, R.T. [Rensselaer Polytechnic Institute, Troy, NY (United States)] [and others

    1995-09-01

    This paper is concerned with the modeling of severe accident phenomena in boiling water reactors (BWR). New models of core melting and in-vessel corium debris relocation are presented, developed for implementation in the APRIL computer code. The results of model testing and validations are given, including comparisons against available experimental data and parametric/sensitivity studies. Also, the application of these models, as parts of the APRIL code, is presented to simulate accident progression in a typical BWR reactor.

  16. MEB 2013, Regulation for Administrator Assignment and Relocation Based On the Opinions of Administrators

    OpenAIRE

    Doğan, Soner; DEMİR, Selçuk Beşir; Mehmet Ali PINAR

    2014-01-01

    In this study; it is aimed to determine the opinions of the institution managers concerning the Regulation for Administrator Assignment and Relocation dated February 28, 2013, the scoring criteria in the regulation and the disturbances experienced in the application process of the regulation. The study is carried out in accordance with the phenomenological pattern through qualitative research methods. The participants were determined with the criterion sampling method which is one of the purp...

  17. Evaluation of Transportation Vibration Associated with Relocation of Work in Process As Part of KCRIMS

    Energy Technology Data Exchange (ETDEWEB)

    Hartwig, Troy

    2013-04-01

    During relocation of the Kansas City Plant (KCP) from the site at Bannister Road to the site at Botts Road, work in process (WIP) within a production department must be transported. This report recommends packaging to mitigate vibration levels experienced by products during between-facility transportation. Measurements and analysis demonstrate that this mitigation results in vibration levels less than those experienced by the product during routine production processes within potentially damaging frequency ranges.

  18. New insights into Kilauea's volcano dynamics brought by large-scale relative relocation of microearthquakes

    Science.gov (United States)

    Got, J.-L.; Okubo, P.

    2003-01-01

    We investigated the microseismicity recorded in an active volcano to infer information concerning the volcano structure and long-term dynamics, by using relative relocations and focal mechanisms of microearthquakes. There were 32,000 earthquakes of the Mauna Loa and Kilauea volcanoes recorded by more than eight stations of the Hawaiian Volcano Observatory seismic network between 1988 and 1999. We studied 17,000 of these events and relocated more than 70%, with an accuracy ranging from 10 to 500 m. About 75% of these relocated events are located in the vicinity of subhorizontal decollement planes, at a depth of 8-11 km. However, the striking features revealed by these relocation results are steep southeast dipping fault planes working as reverse faults, clearly located below the decollement plane and which intersect it. If this decollement plane coincides with the pre-Mauna Loa seafloor, as hypothesized by numerous authors, such reverse faults rupture the pre-Mauna Loa oceanic crust. The weight of the volcano and pressure in the magma storage system are possible causes of these ruptures, fully compatible with the local stress tensor computed by Gillard et al. [1996]. Reverse faults are suspected of producing scarps revealed by kilometer-long horizontal slip-perpendicular lineations along the decollement surface and therefore large-scale roughness, asperities, and normal stress variations. These are capable of generating stick-slip, large-magnitude earthquakes, the spatial microseismic pattern observed in the south flank of Kilauea volcano, and Hilina-type instabilities. Rupture intersecting the decollement surface, causing its large-scale roughness, may be an important parameter controlling the growth of Hawaiian volcanoes.

  19. Meanings, functions, and experiences of living at home for individuals with dementia at the critical point of relocation.

    Science.gov (United States)

    Aminzadeh, Faranak; Dalziel, William B; Molnar, Frank J; Garcia, Linda J

    2010-06-01

    The sociophysical home environment is an integral component of everyday coping, self-identity, and well-being for individuals with dementia; however, residential discontinuity is a common experience for many of these individuals. This article examined the meanings, functions, and experiences associated with living at home for individuals with dementia at the critical point of relocation to a residential care facility. Qualitative research methods were used to analyze in-depth interviews with 16 individuals with dementia at their homes within 2 months prior to relocation. At the time of relocation, living at home had become a paradoxical experience for most participants. The findings inform practice and policy interventions at both individual and societal levels to help individuals with dementia age in place for as long as possible and to maximize their efforts to "place" themselves in their new living environments after relocation. Copyright 2010, SLACK Incorporated.

  20. Ossiculoplasty in Intact Stapes and Malleus Patients : A Comparison of PORPs Versus TORPs With Malleus Relocation and Silastic Banding Techniques

    NARCIS (Netherlands)

    Vincent, Robert; Rovers, Maroeska; Mistry, Nina; Oates, John; Sperling, Neil; Grolman, Wilko

    2011-01-01

    Objectives: To compare hearing results in patients undergoing ossiculoplasty using either partial ossicular replacement prosthesis (PORP) or total ossicular replacement prosthesis (TORP) with Silastic banding and malleus relocation techniques in cases with malleus and stapes both present and mobile.

  1. Ossiculoplasty in intact stapes and malleus patients: a comparison of PORPs versus TORPs with malleus relocation and Silastic banding techniques.

    NARCIS (Netherlands)

    Vincent, R.; Rovers, M.M.; Mistry, N.; Oates, J.; Sperling, N.; Grolman, W.

    2011-01-01

    OBJECTIVES: To compare hearing results in patients undergoing ossiculoplasty using either partial ossicular replacement prosthesis (PORP) or total ossicular replacement prosthesis (TORP) with Silastic banding and malleus relocation techniques in cases with malleus and stapes both present and mobile.

  2. Discussion on the Precise Relocation and Seismo-Tectonics of the Jiujiang-Ruichang Earthquake

    Institute of Scientific and Technical Information of China (English)

    Lü Jian; Ni Sidao; Shen Xiaoqi; Gao Jianhua; Zeng Xinfu

    2008-01-01

    Based on relocating the Jiujiang-Ruichang earthquake sequence which occurred on November 26, 2005 in Jiangxi Province with the double-difference (DD) algorithm and master event technique, the paper discusses the focal mechanism of the main shock (Ms5.7) and the probable seismo-tectonics. The precise relocation results indicate that the average horizontal error is 0.31 km in a EW direction and 0.40km in a NS direction, and the average depth error is 0.48km. The focal depths vary from 8kin to 14km, with the predominant distribution at 10km~ 12km. The epicenter of the main shock is relocated to be 29.69° N, 115.74°E and the focal depth is about 10.Skm. Combining the predominant distribution of the earthquake sequence, the focal mechanism of the main shock and the tectonic conditions of NE- and NWstrike faults growth in the seismic region, we infer that the main shock of the earthquake sequence was caused by a NW striking buried fault in the Rnichang basin. The nature of seismic faults needs to be further explored.

  3. Two seismic gaps on the Sagaing Fault, Myanmar, derived from relocation of historical earthquakes since 1918

    Science.gov (United States)

    Hurukawa, Nobuo; Maung Maung, Phyo

    2011-01-01

    Relocation of six M (magnitude) ≥ 7.0 earthquakes near the Sagaing Fault in Myanmar since 1918 allows us to image earthquake history along the Sagaing Fault. All the earthquakes were relocated on the Sagaing Fault by using the modified joint hypocenter determination method. Combining the relocated epicenters with information on foreshocks, aftershocks, seismic intensities, and coseismic displacement, we estimated the location of the fault plane that ruptured during each earthquake. This analysis revealed two seismic gaps: one between 19.2°N and 21.5°N in central Myanmar, and another south of 16.6°N in the Andaman Sea. Considering the length of the first seismic gap (˜260 km), a future earthquake of up to M ˜7.9 is expected to occur in central Myanmar. Because Nay Pyi Taw, the recently established capital of Myanmar, is located on the expected fault, its large population is exposed to a significant earthquake hazard.

  4. (Re)creating community: Experiences of Older Women Forcibly Relocated During Apartheid.

    Science.gov (United States)

    Roos, Vera; Kolobe, Patricia Stockie; Keating, Norah

    2014-01-01

    This article explores sense of community with a group of older African women, who were forcibly relocated during apartheid. The situation of a marginalised group, with a history of disconnection from younger generations and from place, provides an opportunity to consider the relevance of community in later life. The research was conducted at a day centre for older people in the North West Province of South Africa, more than 50 years after forced relocations took place. Eleven older women (70 years and older) participated. Qualitative data were obtained through visual research methods and group discussions and were thematically analysed. Findings were that place and sense of belonging as well as elements of community were relevant. Participants reported limited connections to place in either childhood or current communities. Post relocation, a sense of belonging was expressed only in relation to a shared-interest community of peers that addressed their needs for safety, emotional support and instrumental care. Also, generational relations were strained, giving rise to a sense of loss of a community where both young and old were responsible for each other. Constrained resource communities have a profound impact on opportunities to create a sense of belonging. © 2013 The Authors. Journal of Community & Applied Social Psychology published by John Wiley & Sons Ltd.

  5. [Distribution and pollution assessment of heavy metals in soil of relocation areas from the Danjiangkou Reservoir].

    Science.gov (United States)

    Zhang, Lei; Qin, Yan-Wen; Zheng, Bing-Hui; Shi, Yao; Han, Chao-Nan

    2013-01-01

    The aim of this article is to explore the pollution level and potential ecological risk of heavy metals in soil of the relocation areas from the Danjiangkou Reservoir. The contents and spatial distribution of Cd, Pb, Cu, Zn, Cr and As in soil of the relocation areas from the Danjiangkou Reservoir were analyzed. The integrated pollution index and potential ecological risk index were used to evaluate the contamination degree and potential ecological risk of these elements. The results indicated that the average contents of Cd, Pb, Cu, Zn, Cr and As in the samples were 0.61, 23.11, 58.25, 22.65, 58.99 and 16.95 mg x kg(-1), respectively. Compared with the background value of soils from Henan province, all these 6 elements except Zn were enriched to some extent, especially Cd. Similar patterns were observed for the spatial distribution of Cu, Zn, and Pb. Compared with the contents of heavy metals in surface sediments of the typical domestic reservoirs, Cd and As in soil of the relocation areas from the Danjiangkou Reservoir were heavily accumulated. The correlation analysis showed that there were significant positive correlations among Pb, Cu, and Zn. And there was also significant positive correlation between Cr and Pb. In contrast, negative correlation was found between Cr and As. To sum up, the comprehensive assessment results showed that Cd was the primary element with high ecological risk.

  6. Transitions to long-term care: how do families living with dementia experience mealtimes after relocating?

    Science.gov (United States)

    Henkusens, Caitlin; Keller, Heather H; Dupuis, Sherry; Schindel Martin, Lori

    2014-08-01

    Food and mealtimes play a central role in our lives and often hold great meaning. This study is a secondary analysis of a subset of data collected from a 6-year longitudinal qualitative study called Eating Together (ET), which sought to better understand the experiences around food and mealtimes for community dwelling persons with dementia (PWD) and their primary care partners (CP). Several PWD and, in some cases, their spousal CP, relocated to long-term care (LTC) during the conduct of the ET study. To understand how this relocation influenced the meaning of meals, a subset of those who experienced this transition were selected and analysis specific to this issue was undertaken. Seven families were included in this thematic inductive analysis. Findings revealed five themes related to the different mealtime experience in the LTC home, including systemizing the meal, adjusting to dining with others, holding on to home, evolving mealtime roles, and becoming "at home." Understanding how families adapt to commensal dining in LTC may be relevant to successful relocation. This work furthers this understanding and provides a basis for person-centered mealtime practices that promote adaptation.

  7. The Outsourcing-to-Insourcing Relocation Shift: A Response of U.S. Manufacturers to the Outsourcing Paradigm

    Science.gov (United States)

    2013-06-01

    relocation decision and the process applied (how?) to effect the implementation of the relocation decision . Qualitative research methods were selected to... Ellram , 1997). If, as has been well documented, there are significant value positions to be taken in long-term buyer- supplier contracts / exchanges...work done in the area of supplier relationship management (for example see Park et al., (2010)), to include areas such as supplier selection and

  8. HYPODD Relocations and Stress Tensor Inversion Analyses of Local Earthquake Clusters in the Sea of Marmara

    Science.gov (United States)

    Korkusuz Öztürk, Yasemin; Meral Özel, Nurcan

    2016-04-01

    Extensional focal mechanism solutions are mostly observed even in the Central Marmara by this comprehensive research although the main Marmara Fault that is the western branch of the NAF, is dominated by a right lateral strike-slip regime. Marmara Region, a seismically very active area, is located at the western section of the North Anatolian Fault Zone (NAFZ). The 1912 Mürefte and 1999 Izmit earthquakes are the last devastating events of the western and eastern sections of this region, respectively. The region between the locations of these earthquakes, is prone to a large earthquake. Therefore, the analysis of the Sea of Marmara is significant. The main objective of this research is to determine earthquake hypocenters and focal mechanism solutions accurately, hence we obtain recent states of stresses for this region. Accordingly, this research aims to define branches of fault structures and its geometrical orientations in the Sea of Marmara. In this study, a cluster of events in the Central Marmara is analyzed using hypocenter program as a usual location technique. In addition, these events and other clustered events (Korkusuz Öztürk et al., 2015) are relocated using HYPODD relocation procedure. Even though NAF is mostly dominated by a right lateral strike slip fault, we found out many extensional source mechanisms. Also, from the comparison of relocation results of hypocenter and HYPODD programs, it is found out that most of the relocations have the same orientations and dipping angles of the segments of the main Marmara Fault are not clear. As a result, since we observe many normal faulting mechanisms in the Sea of Marmara, we expect to observe some deviations in orientations of vertical orientations of the fault segments comparing a dip-slip model. Therefore, this research will continue to clearly identify fault dip angles of main fault segments in Marmara Sea. Further, our sensitive relocation and stress analyses will make an important contribution to a

  9. Motivations for active commuting: a qualitative investigation of the period of home or work relocation

    Directory of Open Access Journals (Sweden)

    Jones Caroline HD

    2012-09-01

    Full Text Available Abstract Background Promoting walking or cycling to work (active commuting could help to increase population physical activity levels. According to the habit discontinuity and residential self-selection hypotheses, moving home or workplace is a period when people (reassess, and may be more likely to change, their travel behavior. Research in this area is dominated by the use of quantitative research methods, but qualitative approaches can provide in-depth insight into the experiences and processes of travel behavior change. This qualitative study aimed to explore experiences and motivations regarding travel behavior around the period of relocation, in an effort to understand how active commuting might be promoted more effectively. Methods Participants were recruited from the Commuting and Health in Cambridge study cohort in the UK. Commuters who had moved home, workplace or both between 2009 and 2010 were identified, and a purposive sample was invited to participate in semi-structured interviews regarding their experiences of, and travel behavior before and after, relocating. A grounded theory approach was taken to analysis. Results Twenty-six commuters participated. Participants were motivated by convenience, speed, cost and reliability when selecting modes of travel for commuting. Physical activity was not a primary motivation, but incidental increases in physical activity were described and valued in association with active commuting, the use of public transport and the use of park-and-ride facilities. Conclusions Emphasizing and improving the relative convenience, cost, speed and reliability of active commuting may be a more promising approach to promoting its uptake than emphasizing the health benefits, at least around the time of relocation. Providing good quality public transport and free car parking within walking or cycling distance of major employment sites may encourage the inclusion of active travel in the journey to work

  10. A homogeneous earthquake catalogue of relocated recent shallow events of the Hellenic arc

    Science.gov (United States)

    Kolligri, Maria; Scordilis, Emmanuel; Koutrakis, Stelios; Evangelidis, Christos; Papazachos, Constantinos; Karakaisis, George; Drakatos, George; Vallianatos, Filippos

    2014-05-01

    The aim of this study is the compilation of a new homogeneous (with respect to magnitude) catalogue for shallow (h3.0 were considered, resulting in the generation of a unified data-base with phase readings from 13535 earthquakes. Three location algorithms were used for the initial relocation procedure, namely the HYPO71 earthquake location program (Lee & Lahr, 1972), the HYPOINVERSE algorithm (Klein, 2002) and the double-difference algorithm, HYPODD (Waldhauser & Ellsworth, 2000). The phase data were initially processed with both absolute location algorithms, namely HYPO71 and HYPOINVERSE algorithm, using the velocity model proposed by Karagianni et al. (2005). This relocation procedure resulted in an updated dataset 12149 earthquakes, for which improved relocations could be provided. The final relocation was performed by applying the double-difference algorithm, HYPODD, using the velocity model proposed for the study area by Karagianni et al. (2002), as it was considered as the more representative. The above procedure allowed the relocation of 8117 earthquakes revealing, in some cases, significant differences in both the depths and the epicenters of these earthquakes, with respect to the initial (HYPO71-HYPOINVERSE) catalogue. Several reports on the magnitudes of the earthquakes of the catalogue were elaborated in order to obtain the most reliable magnitude approximation. The available estimates, derived from several centers, include magnitude values expressed in several magnitude scales. Considering the moment-magnitude scale as the most reliable one, the values of the reported magnitudes of each earthquake were converted to the respective moment magnitudes by using already published converting relations (Papazachos et al., 2002; Scordilis, 2006) and their weighted mean value (inversely proportional to the standard error of each calibrating relation) was taken as the moment magnitude of this earthquake. When original moment magnitudes were available, their values

  11. Fantasy and Reality in Mark Twain's Aggression.

    Science.gov (United States)

    Sears, Robert R.

    Psychoanalysis, a favorite method for studying personality and motivation, cannot be used on the dead. Instead, biographical analysis must be employed. This study examines Mark Twain's aggression by analyzing his writings, social behavior, and environmental aspects of his life. In viewing Mark Twain's novels as representing fantasy, 17 categories…

  12. Effects of heat on cut mark characteristics.

    Science.gov (United States)

    Waltenberger, Lukas; Schutkowski, Holger

    2017-02-01

    Cut marks on bones provide crucial information about tools used and their mode of application, both in archaeological and forensic contexts. Despite a substantial amount of research on cut mark analysis and the influence of fire on bones (shrinkage, fracture pattern, recrystallisation), there is still a lack of knowledge in cut mark analysis on burnt remains. This study provides information about heat alteration of cut marks and whether consistent features can be observed that allow direct interpretation of the implemented tools used. In a controlled experiment, cut marks (n=25) were inflicted on pig ribs (n=7) with a kitchen knife and examined using micro-CT and digital microscopy. The methods were compared in terms of their efficacy in recording cut marks on native and heat-treated bones. Statistical analysis demonstrates that floor angles and the maximum slope height of cuts undergo significant alteration, whereas width, depth, floor radius, slope, and opening angle remain stable. Micro-CT and digital microscopy are both suitable methods for cut mark analysis. However, significant differences in measurements were detected between both methods, as micro-CT is less accurate due to the lower resolution. Moreover, stabbing led to micro-fissures surrounding the cuts, which might also influence the alteration of cut marks.

  13. Mark formation modeling in optical rewritable recording

    NARCIS (Netherlands)

    Brusche, J.H.; Segal, A.; Vuik, C.; Urbach, H.P.

    2006-01-01

    In optical rewritable recording media, such as the Blu-ray Disc, amorphous marks are formed on a crystalline background of a phase-change layer, by means of short, high power laser pulses. In order to improve this data storage concept, it is of great importance to understand the mark formation

  14. Mark Blaug: rebel with many causes

    NARCIS (Netherlands)

    M. Boumans; M. Klaes

    2013-01-01

    This book celebrates the immense contributions of Mark Blaug to every aspect of economics, a discipline in which his influence and relevance still resonate today, particularly in the field of the economics of education. This collection of eminent contributions discusses the ideas and works of Mark B

  15. Recent Discoveries on Antwerp Panel Makers' Marks

    DEFF Research Database (Denmark)

    Wadum, Jørgen

    1993-01-01

    There still exist today uncertainties and misunderstandings in our interpretation of panel makers' marks from early 17th century Antwerp. In the future, panel marks and the panels on which they can be found will certainly render much more information concerning the technology of that time. Still...

  16. 76 FR 490 - Marking Meteorological Evaluation Towers

    Science.gov (United States)

    2011-01-05

    ... Federal Aviation Administration 14 CFR Part 77 Marking Meteorological Evaluation Towers AGENCY: Federal.... SUMMARY: The FAA is considering revising its current Advisory Circular on Obstruction Marking and Lighting to include guidance for Meteorological Evaluation Towers (METs). These towers are erected in...

  17. 76 FR 36983 - Marking Meteorological Evaluation Towers

    Science.gov (United States)

    2011-06-24

    ... terrain. Without a similar evaluation process, the FAA cannot recommend lighting for METs. It is important... Federal Aviation Administration 14 CFR Part 77 Marking Meteorological Evaluation Towers AGENCY: Federal... recommended guidance for the voluntary marking of Meteorological Evaluation Towers (METs) erected in...

  18. 40 CFR 761.40 - Marking requirements.

    Science.gov (United States)

    2010-07-01

    ... time of removal from use if not already marked. ; (3) PCB Large High Voltage Capacitors at the time of... Capacitor at the time of manufacture, at the time of distribution in commerce if not already marked, and at... Capacitors at the time of removal from use (see also paragraph (k) of this section). (6) Electric...

  19. 49 CFR 15.13 - Marking SSI.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Marking SSI. 15.13 Section 15.13 Transportation... SSI. (a) Marking of paper records. In the case of paper records containing SSI, a covered person must... types of records. In the case of non-paper records that contain SSI, including motion picture films...

  20. Mark formation modeling in optical rewritable recording

    NARCIS (Netherlands)

    Brusche, J.H.; Segal, A.; Vuik, C.; Urbach, H.P.

    2006-01-01

    In optical rewritable recording media, such as the Blu-ray Disc, amorphous marks are formed on a crystalline background of a phase-change layer, by means of short, high power laser pulses. In order to improve this data storage concept, it is of great importance to understand the mark formation proce

  1. Credit Documentation and the Mark 15 Subroutine

    Energy Technology Data Exchange (ETDEWEB)

    McAllister, J.E.

    2001-08-16

    This report documents the rewrite of the heat transfer subroutine. Part of the process of preparing the Mark 15 assembly for production operation is the development of thermal-hydraulic limits for the assembly. These limits require, among other items, the development of a Mark 15 assembly subroutine for the CREDIT code.

  2. Teaching Mark through a postcolonial optic

    African Journals Online (AJOL)

    2015-07-16

    Jul 16, 2015 ... But empire (or anti-empire) studies and postcolonial studies are not one and the same. .... presence in Mark 1:1.8 As one scholar put it, 'Mark appears ... back to villages of Galilee (presumably to continue the project inaugurated in Jesus' ... A few chapters later, it is possible to let students see through.

  3. 7 CFR 956.162 - Container markings.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Container markings. 956.162 Section 956.162... WALLA VALLEY OF SOUTHEAST WASHINGTON AND NORTHEAST OREGON Rules and Regulations § 956.162 Container markings. Effective April 15, 1997, no handler shall ship any container of Walla Walla Sweet Onions...

  4. Dengue virus activates membrane TRAIL relocalization and IFN-α production by human plasmacytoid dendritic cells in vitro and in vivo.

    Directory of Open Access Journals (Sweden)

    Mariana Gandini

    Full Text Available BACKGROUND: Dengue displays a broad spectrum of clinical manifestations that may vary from asymptomatic to severe and even fatal features. Plasma leakage/hemorrhages can be caused by a cytokine storm induced by monocytes and dendritic cells during dengue virus (DENV replication. Plasmacytoid dendritic cells (pDCs are innate immune cells and in response to virus exposure secrete IFN-α and express membrane TRAIL (mTRAIL. We aimed to characterize pDC activation in dengue patients and their function under DENV-2 stimulation in vitro. METHODS FINDINGS: Flow cytometry analysis (FCA revealed that pDCs of mild dengue patients exhibit significantly higher frequencies of mTRAIL compared to severe cases or healthy controls. Plasma levels of IFN-α and soluble TRAIL are increased in mild compared to severe dengue patients, positively correlating with pDC activation. FCA experiments showed that in vitro exposure to DENV-2 induced mTRAIL expression on pDC. Furthermore, three dimension microscopy highlighted that TRAIL was relocalized from intracellular compartment to plasma membrane. Chloroquine treatment inhibited DENV-2-induced mTRAIL relocalization and IFN-α production by pDC. Endosomal viral degradation blockade by chloroquine allowed viral antigens detection inside pDCs. All those data are in favor of endocytosis pathway activation by DENV-2 in pDC. Coculture of pDC/DENV-2-infected monocytes revealed a dramatic decrease of antigen detection by FCA. This viral antigens reduction in monocytes was also observed after exogenous IFN-α treatment. Thus, pDC effect on viral load reduction was mainly dependent on IFN-α production. CONCLUSIONS: This investigation characterizes, during DENV-2 infection, activation of pDCs in vivo and their antiviral role in vitro. Thus, we propose TRAIL-expressing pDCs may have an important role in the outcome of disease.

  5. Relocation due to Climate Change: Mapping the Divergent Responses of the Governments of Tuvalu and Kiribati

    Science.gov (United States)

    McNamara, K. E.; Hemstock, S.; Smith, R.; Holland, E. A.

    2012-12-01

    Climate change will continue to impact Pacific Island livelihoods in diverse and complex ways. At the 2009 Copenhagen Conference of Parties to discuss the United Nations Framework Convention on Climate Change, Pacific governments argued for the need to limit warming to 1.5°C. A growing body of literature demonstrates that warming beyond this 2°C threshold is likely and will result in numerous negative impacts on socio-ecological systems across the world, particularly for low-lying coastal communities (Parry et al, 2009; Smith et al, 2009). These communities will need to manage, if possible,a series of interconnected impacts, such as declining freshwater and food security and diminishing land availability, as a result of sea level rise and increasing extreme weather events (Adger and Barnett, 2009). Discussions concerning climate change as a trigger for relocation for low-lying Pacific nations have been contentious, and are fuelled by emotion and varying degrees of sensitivity. As Hayward-Jones (2010: 2) lamented: 'What is at stake over the next decade is not a sinking island but the very viability of life on this fragile atoll state. The land mass of Tuvalu will still exist in 2020 but it may be unable to support the population'. While this debate has historical roots, and indeed the phenomenon of relocation due to localised environmental degradation is not something new in the Pacific, it remains a significant contemporary issue. Scholars have argued that a 'successful mix of strategies' is required to develop culturally-appropriate solutions to this concern about the need for low-lying coastal communities in the Pacific to relocate (Bedford and Bedford, 2010: 93). As such, this paper assesses how the national governments of two low-lying nations in the Pacific - Tuvalu and Kiribati - are mapping out very different long-term strategies to respond to climate change impacts and concerns about the possibility of relocation. The governments of Tuvalu and Kiribati

  6. Relocation consequences on an ophthalmology consultation service from an inpatient to outpatient facility

    Directory of Open Access Journals (Sweden)

    Singh JS

    2015-10-01

    Full Text Available Jorawer S Singh,1 Vincent M Imbrogno,2 Mary K Howard,3 Amandip S Cheema,3 Ausra D Selvadurai,4 Surbhi Bansal5 1Department of Ophthalmology, George Washington University, Washington, DC, 2Contemporary Ophthalmology of Erie, Erie, PA, 3Department of Ophthalmology, University at Buffalo, Buffalo, NY, 4OcuSight Eye Care Center, Rochester, NY, 5Department of Ophthalmology, Virginia Commonwealth University, Richmond, VA, USA Importance: This study shows that relocation of an academic ophthalmology residency program from an inpatient to an outpatient setting in western New York does not affect the consult volume but affects management patterns and follow-up rates.Objective: To investigate the effects on the ophthalmology consultation service of an academic program with relocation from a Regional Level-1 Trauma center to an outpatient facility.Design: Consultation notes from 3 years before and 3 years after the University at Buffalo’s (UB Department of Ophthalmology relocation from a Regional Level-1 Trauma center (Erie County Medical Center to an outpatient facility (Ross Eye Institute were obtained from hospital electronic medical records and analyzed.Setting: Hospitalized care and institutional practice.Participants: All inpatient or Emergency Room Ophthalmology consultation patients from the Department of Ophthalmology at UB from 2004 to 2010 (1,379 patients.Exposures: None, this was a retrospective chart review.Main outcome measures: Patient demographics, reason for consult, diagnoses, and ophthalmic procedures performed by the UB Department of Ophthalmology before and after its relocation.Results: Relocation to the outpatient facility did not affect consult volume (P=0.15. The number of consults focusing on ophthalmic conditions, as a percentage of the yearly total, rose 460% (P=0.0001, while systemic condition consults with ocular manifestations fell 83% (P=0.0001. Consults for ocular trauma decreased 65% (P=0.0034. Consults ending with a

  7. 30 CFR 7.409 - Approval marking.

    Science.gov (United States)

    2010-07-01

    ... approval number in addition to the number and size (gauge) of conductors and cable type. For cables containing electric conductors, the marking shall also include the voltage rating. For splices, the...

  8. Mark Twain, Fenimore Cooper, and Batman.

    Science.gov (United States)

    Crick, Robert Alan

    1992-01-01

    Describes how Mark Twain's essay "Fenimore Cooper's Literary Offenses" helped students to get interested in writing and inspired them to write a similar essay critiquing the movie "Batman." Provides excerpts from students' essays. (PRA)

  9. Mark Making: Methodologies and methods (innovative practice).

    Science.gov (United States)

    Zeilig, Hannah

    2016-09-01

    Mark Making is a recently completed AHRC-funded review exploring the role of the participative arts for people with dementia in the UK. Key concerns underlying Mark Making were both how to privilege the views and feelings of people with a dementia and also how best to understand the value of the arts for people with a dementia. These issues were tackled using a variety of qualitative methods. Methods included a rigorous literature review, the development of a unique web-based map locating many participative arts projects and above all working with people with a dementia to ascertain their views. This brief article will concentrate on some of the innovative methods that the Mark Making team used, with particular reference to comics as a mode of engagement as used in the Descartes project. The article will provide an insight into some of the methodological challenges confronted by Mark Making as well as the inspirations and successes that were enjoyed.

  10. Mark Twain National Wildlife Refuge: Sign Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Mark Twain NWR (including the Louisa District, the Annada District, and the Brussels District) Sign Plan explains how signs are used on the Refuge to help guide...

  11. Mark Twain National Wildlife Refuge Complex : 1980

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Mark Twain National Wildlife Refuge summarizes Refuge activities during the 1980 calendar year. The report begins with a summary of...

  12. 77 FR 4271 - Special Permit Marking Removal

    Science.gov (United States)

    2012-01-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION... Administration (FRA), Department of Transportation (DOT). ACTION: Removal of obsolete Special Permit markings... first shopping event, whichever occurred first. This document relieves tank car owners from that...

  13. 46 CFR 122.602 - Hull markings.

    Science.gov (United States)

    2010-10-01

    ... height, with its upper edge passing through the point of maximum draft. The loading mark must be painted in a contrasting color to the sideshell paint. (e) On a vessel that has a load line, the...

  14. Smoking Leaves Lasting Marks on DNA: Study

    Science.gov (United States)

    ... fullstory_161060.html Smoking Leaves Lasting Marks on DNA: Study Changes related to disease found in more ... cigarettes can leave a lasting imprint on human DNA, altering more than 7,000 genes in ways ...

  15. Environmental Perceptions and Health before and after Relocation to a Green Building.

    Science.gov (United States)

    MacNaughton, Piers; Spengler, John; Vallarino, Jose; Santanam, Suresh; Satish, Usha; Allen, Joseph

    2016-08-01

    Green buildings are designed to have low environmental impacts and improved occupant health and well-being. Improvements to the built environment including ventilation, lighting, and materials have resulted in improved indoor environmental quality (IEQ) in green buildings, but the evidence around occupant health is currently centered around environmental perceptions and self-reported health. To investigate the objective impact of green buildings on health, we tracked IEQ, self-reported health, and heart rate in 30 participants from green and conventional buildings for two weeks. 24 participants were then selected to be relocated to the Syracuse Center of Excellence, a LEED platinum building, for six workdays. While they were there, ventilation, CO2, and volatile organic compound (VOC) levels were changed on different days to match the IEQ of conventional, green, and green+ (green with increased ventilation) buildings. Participants reported improved air quality, odors, thermal comfort, ergonomics, noise and lighting and fewer health symptoms in green buildings prior to relocation. After relocation, participants consistently reported fewer symptoms during the green building conditions compared to the conventional one, yet symptom counts were more closely associated with environmental perceptions than with measured IEQ. On average, participants had 4.7 times the odds of reporting a lack of air movement, 1.4 more symptoms (p-value = 0.019) and a 2 bpm higher heart rate (p-value < 0.001) for a 1000 ppm increase in indoor CO2 concentration. These findings suggest that occupant health in green and conventional buildings is driven by both environmental perceptions and physiological pathways.

  16. Duplication and relocation of the functional DPY19L2 gene within low copy repeats

    Directory of Open Access Journals (Sweden)

    Cheung Joseph

    2006-03-01

    Full Text Available Abstract Background Low copy repeats (LCRs are thought to play an important role in recent gene evolution, especially when they facilitate gene duplications. Duplicate genes are fundamental to adaptive evolution, providing substrates for the development of new or shared gene functions. Moreover, silencing of duplicate genes can have an indirect effect on adaptive evolution by causing genomic relocation of functional genes. These changes are theorized to have been a major factor in speciation. Results Here we present a novel example showing functional gene relocation within a LCR. We characterize the genomic structure and gene content of eight related LCRs on human Chromosomes 7 and 12. Two members of a novel transmembrane gene family, DPY19L, were identified in these regions, along with six transcribed pseudogenes. One of these genes, DPY19L2, is found on Chromosome 12 and is not syntenic with its mouse orthologue. Instead, the human locus syntenic to mouse Dpy19l2 contains a pseudogene, DPY19L2P1. This indicates that the ancestral copy of this gene has been silenced, while the descendant copy has remained active. Thus, the functional copy of this gene has been relocated to a new genomic locus. We then describe the expansion and evolution of the DPY19L gene family from a single gene found in invertebrate animals. Ancient duplications have led to multiple homologues in different lineages, with three in fish, frogs and birds and four in mammals. Conclusion Our results show that the DPY19L family has expanded throughout the vertebrate lineage and has undergone recent primate-specific evolution within LCRs.

  17. [Child health environment in the context of relocating of camp site families to social housing].

    Science.gov (United States)

    Burgos, Soledad; Sigala, Fiorenza; Argueta, Luzmila; Iglesias, Verónica

    2015-01-01

    Housing interventions aimed at overcoming poverty can lead to changes in the health status of children by modifying risk factors in their physical and social environment the aim was to identify children's environmental health factors to change with the relocation of families from slums to public housing. A cross-sectional study was conducted in children ages 2-8 years old of families relocated to public housing (n=115) who were compared to children residing in slums (n=88) in Santiago, Chile. Family socioeconomic characteristics, indoor environment and neighborhoods were collected. It was included respiratory symptoms, accidents and maternal-child care of children. χ2, Fisher and Mann-Whitney test were used to compare groups. There were differences in households related to pets keeping, presence of humidity/molds in homes, types of fuels, and perceived safety problems in neighborhoods (p<0.05). The families from slums reported higher tenancy of pets (73.8% v/s 32.2%%), humidity/molds in homes (43.,2% v/s 18.3%), use of wood for heating (39.8% v/s 0.0%), compared with families of public housing. Residents of public housing perceived more safety problems in neighborhood, and children have more asthma related symptoms and have lower diversity of accidents in home. Among the factors studied, indoor air quality and safety in neighborhoods could be linked to changes from the relocation of families. This reinforces the need to deepen the positive and negative influences of residential mobility of these groups focused on child welfare perspective. Copyright © 2015 Sociedad Chilena de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

  18. Habitat selection by Eld's deer following relocation to a patchy landscape.

    Directory of Open Access Journals (Sweden)

    Duo Pan

    Full Text Available An emerging issue in wildlife conservation is the re-establishment of viable populations of endangered species in suitable habitats. Here, we studied habitat selection by a population of Hainan Eld's deer (Cervus eldi relocated to a patchy landscape of farmland and forest. Hainan Eld's deer were pushed to the brink of extinction in the 1970s, but their population expanded rapidly from 26 to more than 1000 individuals by 2003 through effective reserve protection. As part of a wider relocation and population management strategy, 131 deer were removed from the reserve and reintroduced into a farmland-forest landscape in 2005. Habitat use under a context of human disturbance was surveyed by monitoring 19 radio-collared animals. The majority of deer locations (77% were within 0.6-2 km of villages. Annual home ranges of these collared deer averaged 725 ha (SD 436, which was 55% of the size of the reserve from which they had originated. The annual home ranges contained 54% shrub-grassland, 26% forest and 15% farmland. The relocated deer population selected landscape comprising slash-and-burn agriculture and forest, and avoided both intensively farmed areas and areas containing only forest. Within the selected landscape, deer preferred swiddens and shrub-grasslands. Forests above 300 m in elevation were avoided, whereas forests below 300 m in elevation were overrepresented during the dry season and randomly used during the wet season. Our findings show that reintroduced deer can utilize disturbed habitats, and further demonstrate that subsistence agroforest ecosystems have the capacity to sustain endangered ungulates.

  19. Discrimination and Relocation of The 2013 North Korea Underground Nuclear Test: A New Contribution

    Science.gov (United States)

    Sianipar, D. S.

    2015-12-01

    We successfully give contribution in discriminating the 2013 North Korea underground nuclear test from natural earthquakes by using analysis of ratio of seismic energy and seismic moment (Ɵ) and analysis of the rupture duration. We used the waveform data of the shallow seismic event which occurred in the region of North Korea mainland and vicinity in last decade. We conclude that this earthquake was a shallow seismic event with explosion characteristics and can be discriminated from a natural or tectonic earthquake. The 2013 North Korea test earthquake had 2.817822 x 1019 N.m of the seismic moment and 7.652314 x 1014 N.m of radiated seismic energy and -4.56 of the Ɵ value. The equivalent Ɵ value with the two previous nuclear events and differences with natural earthquakes was considered as an implication of the explosion event. The rupture duration value of this event was 11.13 s. The very low value of the rupture duration from the three nuclear tests event shows us the characteristic of the explosion. We also give contribution in determining the high precision location of the 2013 nuclear test earthquake using relocation algorithm of Modified Joint Hypocenter Determination (MJHD) and double difference using IMS CTBTO, BMKG, regional and global seismic stations respectively. We also compared the relative location results with absolute location method of Simulated Annealing (SA). Results of the all relocation method in this study show the locations with distance less than 7 km from the Punggye-ri nuclear test facility. A result was compared with the relocation results by all possible combination of seismic phase data and stations and by previous researchers and analyzed using topographic data satellite imagery. We proposed that the northwest of the Punggye-ri facility (named "A" location) in coordinate 129.04 E and 41.29 N with elevation around 2050-2150 meter is the high possibility location of the 2013 North Korea underground nuclear test.

  20. Node 3 Relocation Environmental Control and Life Support System Modification Kit Verification and Updated Status

    Science.gov (United States)

    Williams, David E.; Spector Lawrence N.

    2010-01-01

    Node 1 (Unity) flew to International Space Station (ISS) on Flight 2A. Node 1 was the first module of the United States On-Orbit Segment (USOS) launched to ISS. The Node 1 ISS Environmental Control and Life Support (ECLS) design featured limited ECLS capability. The main purpose of Node 1 was to provide internal storage by providing four stowage rack locations within the module and to allow docking of multiple modules and a truss segment to it. The ECLS subsystems inside Node 1 were routed through the element prior to launch to allow for easy integration of the attached future elements, particularly the Habitation Module which was planned to be located at the nadir docking port of Node 1. After Node I was on-orbit, the Program decided not to launch the Habitation Module and instead, to replace it with Node 3 (Tranquility). In 2007, the Program became concerned with a potential Russian docking port approach issue for the Russian FGB nadir docking port after Node 3 is attached to Node 1. To solve this concern the Program decided to relocate Node 3 from Node I nadir to Node 1 port. To support the movement of Node 3 the Program decided to build a modification kit for Node 1, an on-orbit feedthrough leak test device, and new vestibule jumpers to support the ECLS part of the relocation. This paper provides a design overview of the modification kit for Node 1, a summary of the Node 1 ECLS re-verification to support the Node 3 relocation from Node 1 nadir to Node 1 port, and a status of the ECLS modification kit installation into Node 1.

  1. Global teleseismic earthquake relocation with improved travel times and procedures for depth determination

    Science.gov (United States)

    Robert, Engdah E.; Van Hilst, R. D.; Buland, Raymond P.

    1998-01-01

    We relocate nearly 100, 000 events that occurred during the period 1964 to 1995 and are well-constrained teleseismically by arrival-time data reported to the International Seismological Centre (ISC) and to the U. S. Geological Survey's National Earthquake Information Center (NEIC). Hypocenter determination is significantly improved by using, in addition to regional and teleseismic P and S phases, the arrival times of PKiKP, PKPdf, and the teleseismic depth phases pP, pwP, and sP in the relocation procedure. A global probability model developed for later-arriving phases is used to independently identify the depth phases. The relocations are compared to hypocenters reported in the ISC and NEIC catalogs and by other sources. Differences in our epicenters with respect to ISC and NEIC estimates are generally small and regionally systematic due to the combined effects of the observing station network and plate geometry regionally, differences in upper mantle travel times between the reference earth models used, and the use of later-arriving phases. Focal depths are improved substantially over most other independent estimates, demonstrating (for example) how regional structures such as downgoing slabs can severely bias depth estimation when only regional and teleseismic P arrivals are used to determine the hypocenter. The new data base, which is complete to about Mw 5. 2 and includes all events for which moment-tensor solutions are available, has immediate application to high-resolution definition of Wadati-Benioff Zones (WBZs) worldwide, regional and global tomographic imaging, and other studies of earth structure.

  2. Evaluation of RFID Tags to Permanently Mark Trees in Natural Populations

    Science.gov (United States)

    Marczewski, Tobias; Ma, Yongpeng; Sun, Weibang

    2016-01-01

    Long-term ecological and genetic studies in natural populations of tree species require marking techniques so that individuals can be re-visited over time, even in difficult terrain. Both GPS coordinates and physical labels have disadvantages that can make re-finding trees difficult. We tested passive and semi-active radio frequency identification (RFID) tags and readers as a means to relocate individual trees. Passive RFID tags do not provide a good solution because of low transmission power of hand-held readers and strong directionality. Semi-active RFID tags provide detection over longer distances, but also suffer from strong directionality. Active RFID tags promise an improvement over semi-passive tags, and could be evaluated in a future study. We conclude that RFID technology has the potential to improve the ability of researchers to locate individual trees repeatedly under natural conditions, and can be used in conjunction with other marking techniques such as physical tags and GPS coordinates. PMID:27630662

  3. PREOPERATIVE ENDOSCOPIC MARKING OF UNPALPABLE COLONIC TUMORS

    Directory of Open Access Journals (Sweden)

    A. L. Goncharov

    2013-01-01

    Full Text Available The identification of small colon lesions is one of the major problems in laparoscopic colonic resection.Research objective: to develop a technique of visualization of small tumors of a colon by preoperative endoscopic marking of a tumor.Materials and methods. In one day prior to operation to the patient after bowel preparation the colonoscopy is carried out. In the planned point near tumor on antimesentery edge the submucous infiltration of marking solution (Micky Sharpz blue tattoo pigment, UK is made. The volume of entered solution of 1–3 ml. In only 5 months of use of a technique preoperative marking to 14 patients with small (the size of 1–3 cm malignant tumors of the left colon is performed.Results. The tattoo mark was well visualized by during operation at 13 of 14 patients. In all cases we recorded no complications. Time of operation with preoperative marking averaged 108 min, that is significantly less in comparison with average time of operation with an intra-operative colonoscopy – 155 min (р < 0.001.Conclusions. The first experience of preoperative endoscopic marking of non palpable small tumors of a colon is encouraging. Performance of a technique wasn't accompanied by complications and allowed to reduce significantly time of operation and to simplify conditions of performance of operation.

  4. Enamel-based mark performance for marking Chinese mystery snail Bellamya chinensis

    Science.gov (United States)

    Wong, Alec; Allen, Craig R.; Hart, Noelle M.; Haak, Danielle M.; Pope, Kevin L.; Smeenk, Nicholas A.; Stephen, Bruce J.; Uden, Daniel R.

    2013-01-01

    The exoskeleton of gastropods provides a convenient surface for carrying marks, and i the interest of improving future marking methods our laboratory assessed the performance of an enamel paint. The endurance of the paint was also compared to other marking methods assessed in the past. We marked the shells of 30 adult Chinese mystery snails Bellamya chinensis and held them in an aquarium for 181 days. We observed no complete degradation of any enamel-paint mark during the 181 days. The enamel-paint mark was superior to a nai;-polish mark, which lasted a median of 100 days. Enamel-paint marks also have a lower rate of loss (0.00 month-1 181 days) than plastic bee tags (0.01 month-1, 57 days), gouache paint (0.07 month-1, 18.5 days), or car body paint from studies found in scientific literature. Legibility of enamel-paint marks had a median lifetime of 102 days. The use of enamel paint on the shells of gastropods is a viable option for studies lasting up to 6 months. Furthermore, visits to capture-mark-recapture site 1 year after application of enamel-paint marks on B. chinesnis shells produced several individuals on which the enamel paint was still visible, although further testing is required to clarify durability over longer periods.

  5. Thermophysical, hydrodynamic and mechanical aspects of molten core relocation to lower plenum

    Energy Technology Data Exchange (ETDEWEB)

    Suh, Kune Y.; Huh, Chang Wook [Seoul National University, Seoul (Korea, Republic of)

    1997-12-31

    This paper presents the current state of knowledge on molten material relocation into the lower plenum. Consequences of movement of material to the lower head are considered with regard to the potential for reactor pressure vessel failure from both thermal hydraulic and mechanical standpoints. The models are applied to evaluating various in-vessel retention strategies for the Korean Standard Power Plant (KSNPP) reactor. The results are summarized in terms of thermal response of the reactor vessel from the very relevant severe accident management perspective. 10 refs., 1 fig., 1 tab. (Author)

  6. p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy

    DEFF Research Database (Denmark)

    Song, Yun Ju C; Lundvig, Ditte M S; Huang, Yue

    2007-01-01

    was revealed by immunoblotting along with the presence of immunoreactivity for MBP degradation products in oligodendroglia. The oligodendroglial cell bodies in MSA displayed an enlargement along with the relocalization of p25alpha, and this was enhanced after the deposition of alpha-synuclein in the glial...... cytoplasmic inclusions. Overall, the data indicate that changes in the cellular interactions between MBP and p25alpha occur early in MSA and contribute to abnormalities in myelin and subsequent alpha-synuclein aggregation and the ensuing neuronal degeneration that characterizes this disease....

  7. How to assess the compensations for home relocation: the case of the Malpensa airport

    Directory of Open Access Journals (Sweden)

    Alessandra Oppio

    2016-01-01

    Full Text Available The development of the Malpensa airport into a Hub for the Central and South Europe has produced on one side relevant economic impacts, on the other one considerable environmental problems, due to the noise and atmospheric pollution, especially for the inhabitants who live within a distance of 400 meters from the airport.  In the face of this difficult situation, the Lombardy Region has endorsed an agreement for relocating and compensating households affected by the environmental negative externalities. In this context the paper introduces the appraisal procedure used for estimating compensations and discusses the results, mostly in terms of deviation from the expected values and effectiveness of the model.

  8. Globalised Markets and Localised Needs. Relocating Design Competence in a New Industrial Context

    DEFF Research Database (Denmark)

    Morelli, Nicola

    2006-01-01

    Globalisation implies several phenomena, such as the expansion of markets and the relocation of production. However the success of global production is linked to business companies’ capability to generate local and individualized solutions. In order to put together global production and local...... solutions, industries have to develop a new capability to mobilize local networks of actors and enable final customers to play an active role in the production of the final solution. This implies a radical change in the social role of business companies and, from the designer’s perspective, a genetic change...

  9. Hypocenter relocation using a fast grid search method and a 3-D seismic velocity model for the Sumatra region

    Science.gov (United States)

    Nugroho, Hendro; Widiyantoro, Sri; Nugraha, Andri Dian

    2013-09-01

    Determination of earthquake hypocenter in Indonesia conducted by the Meteorological, Climatological, and Geophysical Agency (MCGA) has still used a 1-D seismic velocity model. In this research, we have applied a Fast Grid Search (FGM) method and a 3-D velocity model resulting from tomographic imaging to relocate earthquakes in the Sumatran region. The data were taken from the MCGA data catalog from 2009 to 2011 comprising of subduction zone and on land fault earthquakes with magnitude greater than 4 Mw. Our preliminary results show some significant changes in the depths of the relocated earthquakes which are in general deeper than the depths of hypocenters from the MCGA data catalog. The residual times resulting from the relocation process are smaller than those prior to the relocation. Encouraged by these results, we will continue to conduct hypocenter relocation for all events from the MCGA data catalog periodically in order to produce a new data catalog with good quality. We hope that the new data catalog will be useful for further studies.

  10. Hypocenter relocation using a fast grid search method and a 3-D seismic velocity model for the Sumatra region

    Energy Technology Data Exchange (ETDEWEB)

    Nugroho, Hendro [Study Program of Earth Sciences, Faculty of Earth Sciences and Technology, Institute of Technology Bandung, Jl. Ganesha No. 10, Bandung 40132, Indonesia and Meteorological, Climatological, and Geophysical Agency, Jl. Angkasa 1 No. 2, Kemayoran, Jakar (Indonesia); Widiyantoro, Sri [Global Geophysics Research Group, Faculty of Mining and Petroleum Engineering, Institute of Technology Bandung, Jl. Ganesha No. 10, Bandung 40132 (Indonesia); Nugraha, Andri Dian [Global Geophysics Research Group, Faculty of Mining and Petroleum Engineering, Institute of Technologyc Bandung, Jl. Ganesha No. 10, Bandung 40132 (Indonesia)

    2013-09-09

    Determination of earthquake hypocenter in Indonesia conducted by the Meteorological, Climatological, and Geophysical Agency (MCGA) has still used a 1-D seismic velocity model. In this research, we have applied a Fast Grid Search (FGM) method and a 3-D velocity model resulting from tomographic imaging to relocate earthquakes in the Sumatran region. The data were taken from the MCGA data catalog from 2009 to 2011 comprising of subduction zone and on land fault earthquakes with magnitude greater than 4 Mw. Our preliminary results show some significant changes in the depths of the relocated earthquakes which are in general deeper than the depths of hypocenters from the MCGA data catalog. The residual times resulting from the relocation process are smaller than those prior to the relocation. Encouraged by these results, we will continue to conduct hypocenter relocation for all events from the MCGA data catalog periodically in order to produce a new data catalog with good quality. We hope that the new data catalog will be useful for further studies.

  11. Study of the laser marking process of cold sprayed titanium coatings on aluminium substrates

    Science.gov (United States)

    Astarita, A.; Genna, S.; Leone, C.; Memola Capece Minutolo, F.; Squillace, A.; Velotti, C.

    2016-09-01

    This paper deals with the study of the laser marking process of titanium cold sprayed coatings on aluminium substrates. Despite several studies regarding the laser marking process are available in literature very few attention have been paid to the marking of cold sprayed coatings and there are no previous papers in literature. Also the phenomena occurring during the marking of a porous coating are to date not fully understood and will be discussed in this paper. The experimental campaign was also repeated on grade 2 titanium rolled sheets with a thickness of 2 mm. The marking tests were carried out under different experimental conditions varying the main process parameters (i.e. laser pulse power and laser scan speed), after that the mark sections were observed by optical microscope and SEM. Both the maximum penetration depth and width of the marks were acquired and also internal damages induced by the process were studied. A correlation between the process parameters and the mark's geometry was found. The results show the effectiveness of the laser process to produce high quality marks on both the titanium layer and the titanium sheet. Moreover, a higher mark penetration on Ti coating was observed compared to the Ti sheet. However, the results show also the possibility to introduce severe and hidden damages in both materials if the process parameters are not properly set.

  12. Forensic surface metrology: tool mark evidence.

    Science.gov (United States)

    Gambino, Carol; McLaughlin, Patrick; Kuo, Loretta; Kammerman, Frani; Shenkin, Peter; Diaczuk, Peter; Petraco, Nicholas; Hamby, James; Petraco, Nicholas D K

    2011-01-01

    Over the last several decades, forensic examiners of impression evidence have come under scrutiny in the courtroom due to analysis methods that rely heavily on subjective morphological comparisons. Currently, there is no universally accepted system that generates numerical data to independently corroborate visual comparisons. Our research attempts to develop such a system for tool mark evidence, proposing a methodology that objectively evaluates the association of striated tool marks with the tools that generated them. In our study, 58 primer shear marks on 9 mm cartridge cases, fired from four Glock model 19 pistols, were collected using high-resolution white light confocal microscopy. The resulting three-dimensional surface topographies were filtered to extract all "waviness surfaces"-the essential "line" information that firearm and tool mark examiners view under a microscope. Extracted waviness profiles were processed with principal component analysis (PCA) for dimension reduction. Support vector machines (SVM) were used to make the profile-gun associations, and conformal prediction theory (CPT) for establishing confidence levels. At the 95% confidence level, CPT coupled with PCA-SVM yielded an empirical error rate of 3.5%. Complementary, bootstrap-based computations for estimated error rates were 0%, indicating that the error rate for the algorithmic procedure is likely to remain low on larger data sets. Finally, suggestions are made for practical courtroom application of CPT for assigning levels of confidence to SVM identifications of tool marks recorded with confocal microscopy.

  13. LANE MARKING DETECTION IN CLUTTERED ENVIRONMENT

    Institute of Scientific and Technical Information of China (English)

    李青; 郑南宁; 程洪

    2003-01-01

    Objective To determine the positions of marking in the presence of distracting shadows, highlight, pavement cracks, etc. Methods RGB color space is transformed into I1I2I3 color space and I2 component was used to form a new image with less effect of the clutter. Using an improved edge detection operator, an edge strength map was produced, and binarilized by adaptive thresholds. The binary image was labeled and circularity of all connected components is calculated. The Self-Organizing Mapping is adopted to extract regions which imply potential marking. Finally the position of marking was obtained by curve fitting. Results Color information was utilized fully, all thresholds were set adaptively and lane marking could be detected in challenging images with shadows, highlight or other cars. Conclusion The method based on circularity of connected components shows its outstanding robustness to lane marking detection and has a wide variety of applications in the areas of vehicle autonomous navigation and driver assistance system.

  14. Preliminary evaluation of crisis-relocation fallout-shelter options. Volume 2. Detailed analysis

    Energy Technology Data Exchange (ETDEWEB)

    Santini, D.J.; Clinch, J.M.; Davis, F.H.; Hill, L.G.; Lynch, E.P.; Tanzman, E.A.; Wernette, D.R.

    1982-12-01

    This report presents a preliminary, detailed evaluation of various shelter options for use if the President orders crisis relocation of the US urban population because of strong expectation of a nuclear war. The availability of livable shelter space at 40 ft/sup 2/ per person (congregate-care space) by state is evaluated. Options are evaluated for construction of fallout shelters allowing 10 ft/sup 2/ per person - such shelters are designed to provide 100% survival at projected levels of radioactive fallout. The FEMA concept of upgrading existing buildings to act as fallout shelters can, in principle, provide adequate shelter throughout most of the US. Exceptions are noted and remedies proposed. In terms of upgrading existing buildings to fallout shelter status, great benefits are possible by turning away from a standard national approach and adopting a more site-specific approach. Existing FEMA research provides a solid foundation for successful crisis relocation planning, but the program can be refined by making suitable modifications in its locational, engineering, and institutionally specific elements.

  15. DYNAMIC RELOCATION OF PLANT/WAREHOUSE FACILITIES:A FAST COMPACT GENETIC ALGORITHM APPROACH

    Institute of Scientific and Technical Information of China (English)

    Li Shugang; Wu Zhiming; Pang Xiaohong

    2004-01-01

    The problem of dynamic relocation and phase-out of combined manufacturing plant and warehousing facilities in the supply chain are concerned.A multiple time/multiple objective model is proposed to maximize total profit during the time horizon, minimize total access time from the plant/warehouse facilities to its suppliers and customers and maximize aggregated local incentives during the time horizon.The relocation problem keeps the feature of NP-hard and with the traditional method the optimal result cannot be got easily.So a compact genetic algorithm (CGA) is introduced to solve the problem.In order to accelerate the convergence speed of the CGA, the least square approach is introduced and a fast compact genetic algorithm (fCGA) is proposed.Finally, simulation results with the fCGA are compared with the CGA and classical integer programming (IP).The results show that the fCGA proposed is of high efficiency for Pareto optimality problem.

  16. Characteristics of Relocated Quiet Zones Using Virtual Microphone Algorithm in an Active Headrest System

    Directory of Open Access Journals (Sweden)

    Seokhoon Ryu

    2016-01-01

    Full Text Available This study displays theoretical and experimental investigation on the characteristics of the relocated zone of quiet by a virtual microphone (VM based filtered-x LMS (FxLMS algorithm which can be embedded in a real-time digital controller for an active headrest system. The attenuation changes at the relocated zones of quiet by the variation of the distance between the ear and the error microphone are mainly examined. An active headrest system was implemented for the control experiment at a chair and consists of two (left and right secondary loudspeakers, two error microphones, two observer microphones at ear positions in a HATS, and other electronics including a dSPACE 1401 controller. The VM based FxLMS algorithm achieved an attenuation of about 22 dB in the control experiment against a narrowband primary noise by the variation of the distance between the ear and the error microphone. The important factors for the algorithm are discussed as well.

  17. THE ROMANIAN RURAL SPACE AND ITS LANDSCAPES: ATTRACTION AND MOTIVATION FOR RELOCATING TOWNSPEOPLE

    Directory of Open Access Journals (Sweden)

    IULIAN DINCĂ

    2015-05-01

    Full Text Available The Romanian Rural Space And Its Landscapes: Attraction And Motivation For Relocating Townspeople. It is an easily noticed fact that a new generation of residents has been establishing new habitation structures all over Romania. This also applies to the south-eastern Oradea Suburban Area, in north-western Romania. The analysed suburban landscapes bring out open attitudes in former city dwellers, strongly biased pro-landscape (78.52% of all interviewees. The landscape criterion ranks second in reasons for relocation, indicating that local nature meets the expectations of the new residents. Indubitable spiritual benefits are also involved, the new residents’ perception of local landscapes being dominated by responses like beauty, repose, naturalness. However, the new residents do not have a narrowed-down, specialised definition in their minds when expressing opinions on local landscape physiognomy in detail, and on outstanding features that render local landscapes attractive. Even the landscape management interventions of new residents and of local authorities revolve around land estate categories and tailored urbanistic requisitions. Consequently, the configuration of neo-landscapes with a distinct suburban identity emerges. The major directions of this case study may serve as groundwork for further studies on the issue of landscape as subject matter in attracting city dwellers to suburban locations.

  18. The effect of relocation of whole-crop wheat and corn silages on their quality.

    Science.gov (United States)

    Chen, Y; Weinberg, Z G

    2014-01-01

    Whole-crop wheat and corn silages in 1.5-L anaerobic jars were exposed to air for 0 up to 48 h during their anaerobic storage period to simulate relocation of silages. Ensiling treatments included control (no additives) and either Koffosil T (Koffolk Inc., Petah Tikva, Israel) comprising a mixture of organic acids or Lactobacillus plantarum MTD1 (Ecosyl Products Ltd., Stokesley, UK). In the first set of experiments, the duration of exposure to air had little effect on ensiling parameters or on the aerobic stability of the final silages. In the second set of experiments, both the inoculant and duration of exposure to air had an effect on various fermentation parameters and on the aerobic stability of the final silages. We concluded that if the silages are of good quality, the duration of the relocation process has little effect on silage quality or its aerobic stability. However, if the silage contains any factor that may affect its aerobic stability, it is more sensitive to the time it takes to re-ensile the forage.

  19. Real-Time RGB-D Camera Relocalization via Randomized Ferns for Keyframe Encoding.

    Science.gov (United States)

    Glocker, Ben; Shotton, Jamie; Criminisi, Antonio; Izadi, Shahram

    2015-05-01

    Recovery from tracking failure is essential in any simultaneous localization and tracking system. In this context, we explore an efficient keyframe-based relocalization method based on frame encoding using randomized ferns. The method enables automatic discovery of keyframes through online harvesting in tracking mode, and fast retrieval of pose candidates in the case when tracking is lost. Frame encoding is achieved by applying simple binary feature tests which are stored in the nodes of an ensemble of randomized ferns. The concatenation of small block codes generated by each fern yields a global compact representation of camera frames. Based on those representations we define the frame dissimilarity as the block-wise hamming distance (BlockHD). Dissimilarities between an incoming query frame and a large set of keyframes can be efficiently evaluated by simply traversing the nodes of the ferns and counting image co-occurrences in corresponding code tables. In tracking mode, those dissimilarities decide whether a frame/pose pair is considered as a novel keyframe. For tracking recovery, poses of the most similar keyframes are retrieved and used for reinitialization of the tracking algorithm. The integration of our relocalization method into a hand-held KinectFusion system allows seamless continuation of mapping even when tracking is frequently lost.

  20. Minimizing Thermal Stress for Data Center Servers through Thermal-Aware Relocation

    Science.gov (United States)

    Ling, T. C.; Hussain, S. A.

    2014-01-01

    A rise in inlet air temperature may lower the rate of heat dissipation from air cooled computing servers. This introduces a thermal stress to these servers. As a result, the poorly cooled active servers will start conducting heat to the neighboring servers and giving rise to hotspot regions of thermal stress, inside the data center. As a result, the physical hardware of these servers may fail, thus causing performance loss, monetary loss, and higher energy consumption for cooling mechanism. In order to minimize these situations, this paper performs the profiling of inlet temperature sensitivity (ITS) and defines the optimum location for each server to minimize the chances of creating a thermal hotspot and thermal stress. Based upon novel ITS analysis, a thermal state monitoring and server relocation algorithm for data centers is being proposed. The contribution of this paper is bringing the peak outlet temperatures of the relocated servers closer to average outlet temperature by over 5 times, lowering the average peak outlet temperature by 3.5% and minimizing the thermal stress. PMID:24987743

  1. Minimizing Thermal Stress for Data Center Servers through Thermal-Aware Relocation

    Directory of Open Access Journals (Sweden)

    Muhammad Tayyab Chaudhry

    2014-01-01

    Full Text Available A rise in inlet air temperature may lower the rate of heat dissipation from air cooled computing servers. This introduces a thermal stress to these servers. As a result, the poorly cooled active servers will start conducting heat to the neighboring servers and giving rise to hotspot regions of thermal stress, inside the data center. As a result, the physical hardware of these servers may fail, thus causing performance loss, monetary loss, and higher energy consumption for cooling mechanism. In order to minimize these situations, this paper performs the profiling of inlet temperature sensitivity (ITS and defines the optimum location for each server to minimize the chances of creating a thermal hotspot and thermal stress. Based upon novel ITS analysis, a thermal state monitoring and server relocation algorithm for data centers is being proposed. The contribution of this paper is bringing the peak outlet temperatures of the relocated servers closer to average outlet temperature by over 5 times, lowering the average peak outlet temperature by 3.5% and minimizing the thermal stress.

  2. Post-tsunami relocation of fisher settlements in South Asia: evidence from the Coromandel Coast, India.

    Science.gov (United States)

    Bavinck, Maarten; de Klerk, Leo; van der Plaat, Felice; Ravesteijn, Jorik; Angel, Dominique; Arendsen, Hendrik; van Dijk, Tom; de Hoog, Iris; van Koolwijk, Ant; Tuijtel, Stijn; Zuurendonk, Benjamin

    2015-07-01

    The tsunami that struck the coasts of India on 26 December 2004 resulted in the large-scale destruction of fisher habitations. The post-tsunami rehabilitation effort in Tamil Nadu was directed towards relocating fisher settlements in the interior. This paper discusses the outcomes of a study on the social effects of relocation in a sample of nine communities along the Coromandel Coast. It concludes that, although the participation of fishing communities in house design and in allocation procedures has been limited, many fisher households are satisfied with the quality of the facilities. The distance of the new settlements to the shore, however, is regarded as an impediment to engaging in the fishing profession, and many fishers are actually moving back to their old locations. This raises questions as to the direction of coastal zone policy in India, as well as to the weight accorded to safety (and other coastal development interests) vis-à-vis the livelihood needs of fishers. © 2015 The Author(s). Disasters © Overseas Development Institute, 2015.

  3. 77 FR 16098 - In the Matter of All Operating Boiling Water Reactor Licensees With Mark I and Mark II...

    Science.gov (United States)

    2012-03-19

    ... the Matter of All Operating Boiling Water Reactor Licensees With Mark I and Mark II Containments... operate boiling-water reactors (BWRs) with Mark I and Mark II containment designs. II On March 11, 2011, a... Nuclear Reactor Regulation. Operating Boiling Water Reactor Licenses With Mark I and Mark II Containments...

  4. The national hydrologic bench-mark network

    Science.gov (United States)

    Cobb, Ernest D.; Biesecker, J.E.

    1971-01-01

    The United States is undergoing a dramatic growth of population and demands on its natural resources. The effects are widespread and often produce significant alterations of the environment. The hydrologic bench-mark network was established to provide data on stream basins which are little affected by these changes. The network is made up of selected stream basins which are not expected to be significantly altered by man. Data obtained from these basins can be used to document natural changes in hydrologic characteristics with time, to provide a better understanding of the hydrologic structure of natural basins, and to provide a comparative base for studying the effects of man on the hydrologic environment. There are 57 bench-mark basins in 37 States. These basins are in areas having a wide variety of climate and topography. The bench-mark basins and the types of data collected in the basins are described.

  5. The Mark II Vertex Drift Chamber

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, J.P.; Baggs, R.; Fujino, D.; Hayes, K.; Hoard, C.; Hower, N.; Hutchinson, D.; Jaros, J.A.; Koetke, D.; Kowalski, L.A.

    1989-03-01

    We have completed constructing and begun operating the Mark II Drift Chamber Vertex Detector. The chamber, based on a modified jet cell design, achieves 30 {mu}m spatial resolution and <1000 {mu}m track-pair resolution in pressurized CO{sub 2} gas mixtures. Special emphasis has been placed on controlling systematic errors including the use of novel construction techniques which permit accurate wire placement. Chamber performance has been studied with cosmic ray tracks collected with the chamber located both inside and outside the Mark II. Results on spatial resolution, average pulse shape, and some properties of CO{sub 2} mixtures are presented. 10 refs., 12 figs., 1 tab.

  6. MARK5:n asiakaslupaus ja myynnin argumentaatio

    OpenAIRE

    2015-01-01

    Opinnäytetyön tarkoituksena on rakentaa kohdeyritykselle MARK5:n asiakaslupaus ja myynnin argumentaatio sekä esittää ehdotus asiakaslupauksen ja myynnin argumentaation tuottotavasta, jota kohdeyritys voisi hyödyntää muiden tuotteidensa tai palveluidensa asiakaslupausten ja myynnin argumentaatioiden rakentamisessa. Opinnäytetyö aloitetaan esittelemällä kohdeyritys ja MARK5 sekä määrittelemällä liiketoimintaongelma ja työn tavoitteet. Opinnäytetyön ongelmana on, että kohdeyrityksellä ei ole...

  7. External Ca(2+) is essential for chloroplast movement induced by mechanical stimulation but not by light stimulation.

    Science.gov (United States)

    Sato, Y; Wada, M; Kadota, A

    2001-10-01

    In the fern Adiantum capillus-veneris, chloroplast movement is induced by mechanical stimulation as well as by light stimulation. Directional movement of both types depends on an actin-based motile system. To investigate the physiological relationship between mechanical and light signaling in the regulation of chloroplast movement, we examined the mechano-response of chloroplasts whose motility had been already restricted after photo-relocation. Chloroplast mechano-avoidance movement was induced under all of the photo-relocation conditions tested, indicating that mechano-specific signals generated by mechanical stimulation dominate over the light signals and reactivate the motility of chloroplasts. When the effects of external Ca(2+) on the induction of mechano- and light responses were examined, strikingly different requirements of external Ca(2+) were found for each. In medium without Ca(2+), the mechano-response was suppressed but no effects were observed on photo-response. Mechano-relocation movement of chloroplasts was inhibited by 100 microM lanthanum (La(3+)), a plasma membrane calcium channel blocker, and by 10 microM gadolinium (Gd(3+)), a stretch-activated channel blocker. However, the same concentrations of these drugs did not affect the photo-relocation movement at all. These results suggest that the influx of external Ca(2+) is crucial for the early signaling step of chloroplast mechano-relocation but not for that of photo-relocation. This is the first report showing the separation of signaling pathways in mechano- and photo-relocation of chloroplasts.

  8. Mark Twain's Nemesis: The Paige Compositor.

    Science.gov (United States)

    Goble, Corban

    Samuel Clemens (Mark Twain), who had set type by hand in his youth, had believed that a mechanical composer was beyond the realm of possibility. In 1880, however, he invested $2,000 in an early typesetter invented by James W. Paige. Both Clemens and Paige dreamed of immense wealth that would be generated by selling thousands of Paige Compositors.…

  9. Mark Twain and "The Awful German Language."

    Science.gov (United States)

    Hedderich, Norbert

    2003-01-01

    Analyzes Mark Twain's 1869 essay "The Awful German Language" in terms of Twain's comments on morphological, syntactical, lexical, and phonological features of German. The topic is presented in the context of Twain's German language learning experience. Relevance of the article for German language instruction today is also described. (Author/VWL)

  10. Mark Twain National Wildlife Refuge : Sign Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Mark Twain NWR Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is given as well as a list...

  11. Mark Twain: An Introduction and Interpretation.

    Science.gov (United States)

    Baldanza, Frank

    One of a series of works aimed at presenting contemporary critical opinion on major American authors, this volume contains critical studies of Mark Twain. Designed for use by both literary critics and secondary and college teachers of English, this work would also be of value to undergraduate and graduate students of literature. Topics covered…

  12. Mark Twain and American Humor [Lesson Plan].

    Science.gov (United States)

    2000

    In this three-part lesson, students examine structure and characterization in the short story and consider the significance of humor through a study of Mark Twain's "The Celebrated Jumping Frog of Calaveras County." In Part I, through skits and storytelling, students first examine the structure of Twain's story and the role he creates for his…

  13. A Collar for Marking Big Game Animals

    Science.gov (United States)

    Robert L. Phillips

    1970-01-01

    A Simple, inexpensive collar made of Armor-tite (a vinyl-coated nylon fabric) was designed for marking white-tailed deer (Odocoileus virginianus) and moose (Alces alces). Field tests showed that the material is easily seen and extrememly durable. It may be suitable for use on other large mammals. The collar can be quickly fitted to individual animals under field...

  14. Globaalne palavik ja Nord Stream / Mark Soosaar

    Index Scriptorium Estoniae

    Soosaar, Mark, 1946-

    2009-01-01

    Riigikogu keskkonnakomisjoni liikme Mark Soosaare sõnul peaks Eesti Taani eeskujul jõudma parlamentaarse otsuseni loobuda tuumajaamaehitusest, vähendada tuleks märgatavalt Eesti metsade raiumist. Vene-Saksa gaasitarneleppe vastu töötamise asemel tuleks otsida ühisosa nii Venemaa kui teiste Läänemeremaadega

  15. Eesti oma idamaa kunstnik / Mark Soosaar

    Index Scriptorium Estoniae

    Soosaar, Mark, 1946-

    1999-01-01

    8. apr.-st Pärnu Uue Kunsti Muuseumis veebruaris Soulis idamaise maalikunsti alal magistrikraadi kaitsnud Kati Kalda (sünd. 1971) maalinäitus "Elu korea moodi", Kalev Mark Kostabi maalide väljapanek ning loodusfoto konkursi parimate tööde näitus.

  16. Globaalne palavik ja Nord Stream / Mark Soosaar

    Index Scriptorium Estoniae

    Soosaar, Mark, 1946-

    2009-01-01

    Riigikogu keskkonnakomisjoni liikme Mark Soosaare sõnul peaks Eesti Taani eeskujul jõudma parlamentaarse otsuseni loobuda tuumajaamaehitusest, vähendada tuleks märgatavalt Eesti metsade raiumist. Vene-Saksa gaasitarneleppe vastu töötamise asemel tuleks otsida ühisosa nii Venemaa kui teiste Läänemeremaadega

  17. The Four Marks of Holistic Kinesiology

    Science.gov (United States)

    Twietmeyer, Gregg

    2012-01-01

    What, to borrow a theological phrase, are the marks of a truly holistic kinesiology department? "In Kinesis and the Nature of the Human Person" (2010), I examined the theoretical impact of Aristotle's definition of "kinesis" and Polanyi's theory of "tacit knowledge" on kinesiology. The intention here, however, is practical rather than theoretical.…

  18. Marks & Spencer loob ELis maksupretsedenti / Sirje Rank

    Index Scriptorium Estoniae

    Rank, Sirje, 1966-

    2005-01-01

    Ilmunud ka: Delovõje Vedomosti 13. apr. lk. 6. Briti rõivakett Marks & Spencer kaebas, et Briti maksuseadused, mis ei lubanud emafirma Suurbritannias maksustavast tulust maha kanda Saksamaal, Prantsusmaal ja Belgias asunud tütarfirmade suuri kahjumeid üheksakümnendate aastate lõpus, on vastuolus EL-i ühisturu seadustega

  19. Marks, forfeiture and a constitutional conundrum

    NARCIS (Netherlands)

    Ramalho, A.

    2009-01-01

    In Autumn 2008 a US district court ordered the forfeiture of marks owned by a gang known as the Mongols on the grounds that the gang engaged in illegal activities. While the forfeiture of property is provided for under various US statutes, this case raises more than its fair share of legal and const

  20. Action Research at St Mark's Academy 2013

    Science.gov (United States)

    Elwick, Alex, Ed.; Riggall, Anna, Ed.

    2013-01-01

    St Mark's Church of England Academy is an 11-18 academy situated in Mitcham, South London. It offers a commitment to high achievement within a community of care, underpinned by the Christian values of hope, love and trust. The academy encourages the development of the moral and spiritual well-being of students, alongside their academic success.…

  1. Mark the Evangelist: His African memory

    Directory of Open Access Journals (Sweden)

    Willem Oliver

    2016-05-01

    Full Text Available Mark is the author of the oldest gospel in the Christian Bible. Not much is known about him or his family except for a few references in the Bible. The general assumption, originating in the West, is that Mark was born and bred in Palestine. One of the main proponents of the Western view is Walter Bauer, a German theologian of the first half of the 20th century. His views rely heavily on the argument from silence, as Africa had – and to a great extent still has – an oral culture. Contrary to the Western view, Thomas Oden, an American theologian, did research on the oral culture and investigated the African memory of Mark. This article presents a critical discussion and a review of the book written by Oden in 2011 titled The African memory of Mark. Oden seems to be very subjective in his remarks in favour of Africa, as is also clear from his book titled How Africa shaped the Christian mind, written in 2007, and the question is if he really has enough grounds for his postulations.

  2. Laser Marked Codes For Paperless Tracking Applications

    Science.gov (United States)

    Crater, David

    1987-01-01

    The application of laser markers for marking machine readable codes is described. Use of such codes for automatic tracking and considerations for marker performance and features are discussed. Available laser marker types are reviewed. Compatibility of laser/material combinations and material/code/reader systems are reviewed.

  3. E. Mark Stern (1929-2014).

    Science.gov (United States)

    Vande Kemp, Hendrika

    2014-12-01

    This article memorializes E. Mark Stern (1929 -2014), a clinical psychologist who found his ideological home in humanistic and existential psychology. Highlights of Stern's career and professional contributions are noted. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

  4. Prosodic focus marking in Dali Mandarin

    NARCIS (Netherlands)

    Liu, L.Z.H.; van de Velde, H.; Chen, A.

    2016-01-01

    This study investigated prosodic marking of focus in Dali Mandarin, a variety of Xinan Guanhua (Southwestern Mandarin) spoken in Dali city, the capital of Dali Bai Autonomous Prefecture, China. Dali Mandarin as a variety of Mandarin has had heavy contact with Bai, a Tibeto-Burman language, for a lon

  5. Fingerprint Analysis with Marked Point Processes

    DEFF Research Database (Denmark)

    Forbes, Peter G. M.; Lauritzen, Steffen; Møller, Jesper

    We present a framework for fingerprint matching based on marked point process models. An efficient Monte Carlo algorithm is developed to calculate the marginal likelihood ratio for the hypothesis that two observed prints originate from the same finger against the hypothesis that they originate from...... different fingers. Our model achieves good performance on an NIST-FBI fingerprint database of 258 matched fingerprint pairs....

  6. 49 CFR 172.304 - Marking requirements.

    Science.gov (United States)

    2010-10-01

    ... could substantially reduce its effectiveness. (b) [Reserved] [Amdt. 172-29, 41 FR 15996, Apr. 15, 1976... 49 Transportation 2 2010-10-01 2010-10-01 false Marking requirements. 172.304 Section 172.304... PROVISIONS, HAZARDOUS MATERIALS COMMUNICATIONS, EMERGENCY RESPONSE INFORMATION, TRAINING REQUIREMENTS, AND...

  7. Recent Discoveries on Antwerp Panel Makers' Marks

    DEFF Research Database (Denmark)

    Wadum, Jørgen

    1993-01-01

    more can be added to our comprehension of the way the panel makers worked in Antwerp. In the following paper I shall give a brief summary of the present state of research, as well as outline the complicated task of interpreting these marks and their use as a dating tool. The ready-made supports...

  8. 22 CFR 226.91 - Marking.

    Science.gov (United States)

    2010-04-01

    ... funding, USAID Agreement Officers will request Apparent Successful Applicants to submit a Branding Strategy, defined in § 226.2. The proposed Branding Strategy will not be evaluated competitively. The... marked with the USAID Identity. (1) Any “public communications” as defined in § 226.2, funded by USAID...

  9. Marks & Spencer loob ELis maksupretsedenti / Sirje Rank

    Index Scriptorium Estoniae

    Rank, Sirje, 1966-

    2005-01-01

    Ilmunud ka: Delovõje Vedomosti 13. apr. lk. 6. Briti rõivakett Marks & Spencer kaebas, et Briti maksuseadused, mis ei lubanud emafirma Suurbritannias maksustavast tulust maha kanda Saksamaal, Prantsusmaal ja Belgias asunud tütarfirmade suuri kahjumeid üheksakümnendate aastate lõpus, on vastuolus EL-i ühisturu seadustega

  10. The Four Marks of Holistic Kinesiology

    Science.gov (United States)

    Twietmeyer, Gregg

    2012-01-01

    What, to borrow a theological phrase, are the marks of a truly holistic kinesiology department? "In Kinesis and the Nature of the Human Person" (2010), I examined the theoretical impact of Aristotle's definition of "kinesis" and Polanyi's theory of "tacit knowledge" on kinesiology. The intention here, however, is practical rather than theoretical.…

  11. Do clinicians use more question marks?

    Science.gov (United States)

    Otte, Willem M; van’t Klooster, Maryse A; van Diessen, Eric; Leijten, Frans SS; Sander, Josemir W

    2015-01-01

    Objective To quantify the use of question marks in titles of published studies. Design and setting Literature review. Participants All Pubmed publications between 1 January 2013 and 31 December 2013 with an available abstract. Papers were classified as being clinical when the search terms clin*, med* or patient* were found anywhere in the paper’s title, abstract or the journal’s name. Other papers were considered controls. As a verification, clinical journals were compared to non-clinical journals in two different approaches. Also, 50 highest impact journals were explored for publisher group dependent differences. Main outcome measure Total number of question marks in titles. Results A total of 368,362 papers were classified as clinical and 596,889 as controls. Clinical papers had question marks in 3.9% (95% confidence interval 3.8–4.0%) of titles and other papers in 2.3% (confidence interval 2.3–2.3%; p < 0.001). These findings could be verified for clinical journals compared to non-clinical journals. Different percentages between four publisher groups were found (p < 0.01). Conclusion We found more question marks in titles of clinical papers than in other papers. This could suggest that clinicians often have a question-driven approach to research and scientists in more fundamental research a hypothesis-driven approach. An alternative explanation is that clinicians like catchy titles. Publishing groups might have pro- and anti-question mark policies. PMID:26085937

  12. Relocation and Livelihood Concerns of Sariska Tiger Project, Rajasthan: A Pride or Plight?

    Directory of Open Access Journals (Sweden)

    Muraree Lal Meena

    2015-11-01

    Full Text Available It is well known that Sariska Tiger Reserve is a home to the India’s national animal - the Bengal Tiger (Panthera tigris tigris. The crux of this research is to examine the role of local peoples in the conservation of Sariska Tiger project, which was declared a wildlife reserve way back in 1955 and then further raised to a status of a Tiger Reserve in 1978, and a National Park in 1982. According to the Government officials, the people around the reserve are not only responsible for degrading the reserve, it has also emerged as a safe haven for the poachers involved in illegal hunting of the tigers. One of the reasons identified to be the cause of tiger extinction is the human habitation in the core and in the peripheral areas surrounding the tiger reserves. Despite efforts being made to protect, the Sariska Tiger Reserve, located in Alwar (Rajasthan is seriously facing the problem of tiger extinction. It is estimated that there are around 12 thousand people residing inside the tiger reserve, with 11 villages in the Core Zone-1 area and about 170 villages situated along the peripheries of the reserve. Among the prime measures undertaken are diversions of traffic, relocation of the villages located inside the forest. The Tiger Task Force (2005 has recommended relocation of three key villages surrounding the central area of the Sariska Tiger Reserve. However, this relocation of villages is quite contrary to the life style of the people residing within these villages. Their social and cultural attributes, needs and aspirations have not been given due consideration and the villagers are strongly resenting this move by the government. These displaced villagers have been living in perfect harmony with their environment from time immemorial and it is hard to understand how these villagers can be held responsible for degrading their natural environment, which is their lifeline. The government has failed to take into consideration the role of the

  13. 19 CFR 11.9 - Special marking on certain articles.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Special marking on certain articles. 11.9 Section... OF THE TREASURY PACKING AND STAMPING; MARKING Marking § 11.9 Special marking on certain articles. (a... of additional U.S. Note 4, Chapter 91. If any article so required to be marked is found not to...

  14. Orientation behaviors in residents relocated to a redesigned dementia care unit.

    Science.gov (United States)

    Gibson, Margaret C; MacLean, Jill; Borrie, Michael; Geiger, Julia

    2004-01-01

    This descriptive study took advantage of a scheduled environmental renovation in a secured dementia care unit. A convenience sample of 19 residents who were relocated to the unit completed a performance-based orientation task involving locating their own room. The study included a brief structured interview and tests of psychological function (cognition, depression, and visual-spatial ability) two months after admission. Intrusions (uninvited entry into another resident's room) were tracked for one week. Eighty-four percent of participants were able to find their own rooms during the orientation task. The majority of participants reported use of color (n = 13) and structure (n = 12) as cues for locating their rooms. Thirty-eight percent of those who could find their own rooms also intruded into others' rooms; these intrusions were most commonly related to seeking social interaction. The results attest to the importance of understanding the multiple factors that determine environmental use in this population.

  15. Control of a Multi-Drug-Resistant Acinetobacter baumannii Outbreak after Orthopedics Department Relocation

    Science.gov (United States)

    Gogou, Vasiliki; Meletis, Georgios; Tsitouras, Dimosthenis

    2013-01-01

    Acinetobacter baumannii clinical isolates have the ability to survive in the hospital niche for prolonged time periods and to develop resistance against multiple antimicrobial agents. Therefore, A. baumannii has emerged as an important cause of nosocomial outbreaks worldwide, especially in critical-care environments such as intensive care units. In the present communication, we report a multi-drug-resistant A. baumannii outbreak that occurred in an orthopedics department in Greece after the admission of a patient previously hospitalized in the intensive care unit of a Greek tertiary care hospital. Despite the implementation of infection control measures, 29 patients were infected, significantly raising their hospitalization periods and treatment costs. Interestingly, the outbreak was put under control after the department’s previously programmed relocation. PMID:27694769

  16. Planning and design of a green city in Kaixian for population relocation of Three Gorges Project

    Institute of Scientific and Technical Information of China (English)

    ZENG Wei; JIANG Jia-long; John KOCH-SCHULTE; Neol LEE

    2008-01-01

    We describe the green space system planning and design of a new Kaixian City for migrants in the Three Gorges Reservoir area of P.R.China. The goal of the project was to provide a high quality settlement for migrants relocated from the old Kaixian City that had a history of over one thousand years and from other places with different traditional cultures. Our efforts focused on conceiving affordable strategies to increase green areas, improve waterfront landscapes, deal with water level fluctuation,integrate diverse folk cultures, and encourage bicycling as an environmentally-friendly form of urban transportation.The new city is anticipated to benefit from the green space systems with an improved eco-environment, enriched tourism resources, cheap landscaping costs, relief from traffic pressure, and in other ways. The planning philosophies employed could be useful in the engineering and construction of other cities in the Three Gorges Reservoir area.

  17. A viral protease relocalizes in the presence of the vector to promote vector performance

    Science.gov (United States)

    Bak, Aurélie; Cheung, Andrea L.; Yang, Chunling; Whitham, Steven A.; Casteel, Clare L.

    2017-01-01

    Vector-borne pathogens influence host characteristics relevant to host–vector contact, increasing pathogen transmission and survival. Previously, we demonstrated that infection with Turnip mosaic virus, a member of one of the largest families of plant-infecting viruses, increases vector attraction and reproduction on infected hosts. These changes were due to a single viral protein, NIa-Pro. Here we show that NIa-Pro responds to the presence of the aphid vector during infection by relocalizing to the vacuole. Remarkably, vacuolar localization is required for NIa-Pro's ability to enhance aphid reproduction on host plants, vacuole localization disappears when aphids are removed, and this phenomenon occurs for another potyvirus, Potato virus Y, suggesting a conserved role for the protein in vector–host interactions. Taken together, these results suggest that potyviruses dynamically respond to the presence of their vectors, promoting insect performance and transmission only when needed. PMID:28205516

  18. The reproduction of gender norms through downsizing in later life residential relocation.

    Science.gov (United States)

    Addington, Aislinn; Ekerdt, David J

    2014-01-01

    Using data collected from qualitative interviews in 36 households, this article examines people's use of social relations based on gender to perform tasks associated with residential relocation in later life. Without prompting, our respondents addressed the social relations of gender in the meanings of things, in the persons of gift recipients, and in the persons of actors accomplishing the tasks. They matched gender-typed objects to same-sex recipients, reproducing circumstances of possession and passing on expectations for gender identity. The accounts of our respondents also depicted a gendered division of household labor between husbands and wives and a gendered division of care work by daughters and sons. These strategies economized a big task by shaping decisions about who should get what and who will do what. In turn, these practices affirmed the gendered nature of possession and care work into another generation.

  19. PSYCHOLOGICAL ASSESSMENT AND INTERNATIONAL LAW: CROSS-BORDER RELOCATIONS AND ABDUCTION OF CHILDREN

    Directory of Open Access Journals (Sweden)

    Carles Rodríguez Domínguez

    2015-01-01

    Full Text Available Globalisation has produced a new world order of profound socio-economic transformations that have caused dramatic changes, unprecedented in history, and together with the women's revolution they have introduced new challenges for the model of family and society. Divorce between spouses of different nationalities has significantly increased the number of international relocations of children - with or without abduction-, affecting both the judicial decision-making regarding the care and custody, as well as the forensic psychological evaluations. The objective of this article is to reflect upon the task of the expert forensic psychologist in cases of international transfers or child abduction that will help to deepen our understanding of these cases, for which it is necessary to understand the current legislative framework, among other issues.

  20. New City = New Friends?The Restructuring of Social Resources after Relocation

    Directory of Open Access Journals (Sweden)

    Natascha Nisic

    2013-05-01

    Full Text Available Despite the significance of spatially proximate social contacts, there is little evidence about the effects of residential mobility on the social capital available to an individual. Based on theoretical considerations of the accumulation process of social capital after relocation, we derive hypotheses about the consequences of residential mobility on social capital. Firstly, we expect a partial devaluation of social capital in the origin region after the move and compensatory investments in social capital at the new location. Secondly, we assume that social capital increases with the length of residence and distinguish accumulation and consolidation phases. Multivariate analysis based on survey data yields the expected consequences of mobility. Movers and native residents possess an equal amount of social capital; however, the composition of social capital differs between the two groups. Additionally, we decompose the length of residence into several time intervals to provide evidence for both the constituting and consolidating phases in the creation of social capital.

  1. Repositioning forelimb superficialis muscles: tendon attachment and muscle activity enable active relocation of functional myofibers.

    Science.gov (United States)

    Huang, Alice H; Riordan, Timothy J; Wang, Lingyan; Eyal, Shai; Zelzer, Elazar; Brigande, John V; Schweitzer, Ronen

    2013-09-16

    The muscles that govern hand motion are composed of extrinsic muscles that reside within the forearm and intrinsic muscles that reside within the hand. We find that the extrinsic muscles of the flexor digitorum superficialis (FDS) first differentiate as intrinsic muscles within the hand and then relocate as myofibers to their final position in the arm. This remarkable translocation of differentiated myofibers across a joint is dependent on muscle contraction and muscle-tendon attachment. Interestingly, the intrinsic flexor digitorum brevis (FDB) muscles of the foot are identical to the FDS in tendon pattern and delayed developmental timing but undergo limited muscle translocation, providing strong support for evolutionary homology between the FDS and FDB muscles. We propose that the intrinsic FDB pattern represents the original tetrapod limb and that translocation of the muscles to form the FDS is a mammalian evolutionary addition.

  2. Return or relocate? An inductive analysis of decision-making in a disaster.

    Science.gov (United States)

    Henry, Jacques

    2013-04-01

    This paper proposes an inductive analysis of the decision as to whether to return or to relocate by persons in the State of Louisiana, United States, who evacuated after Hurricanes Katrina and Rita in August and September 2005, respectively. Drawing on interviews with evacuees in these events and extensive fieldwork in the impacted area, the paper seeks to identify the folk dimensions of the decision-making process, assess their arrangements, and situate the process in the larger context of risk and resilience in an advanced society. It suggests that, despite the material and emotional upheaval experienced by affected persons, the decision-making process is a rational endeavour combining a definite set of tightly interconnected factors, involving material dimensions and substantive values that can act in concert or in conflict. In addition, it indicates that there are significant variations by geographic areas, homeownership, and kind of decision. Some theoretical implications, practical measures, and suggestions for future research are examined.

  3. Discrete element method study of fuel relocation and dispersal during loss-of-coolant accidents

    Science.gov (United States)

    Govers, K.; Verwerft, M.

    2016-09-01

    The fuel fragmentation, relocation and dispersal (FFRD) during LOCA transients today retain the attention of the nuclear safety community. The fine fragmentation observed at high burnup may, indeed, affect the Emergency Core Cooling System performance: accumulation of fuel debris in the cladding ballooned zone leads to a redistribution of the temperature profile, while dispersal of debris might lead to coolant blockage or to debris circulation through the primary circuit. This work presents a contribution, by discrete element method, towards a mechanistic description of the various stages of FFRD. The fuel fragments are described as a set of interacting particles, behaving as a granular medium. The model shows qualitative and quantitative agreement with experimental observations, such as the packing efficiency in the balloon, which is shown to stabilize at about 55%. The model is then applied to study fuel dispersal, for which experimental parametric studies are both difficult and expensive.

  4. Optimization of hospital ward resources with patient relocation using Markov chain modeling

    DEFF Research Database (Denmark)

    Andersen, Anders Reenberg; Nielsen, Bo Friis; Reinhardt, Line Blander

    2017-01-01

    Overcrowding of hospital wards is a well-known and often revisited problem in the literature, yet it appears in many different variations. In this study, we present a mathematical model to solve the problem of ensuring sufficient beds to hospital wards by re-distributing beds that are already...... that patient occupancy is reflected by our Markov chain model, and that a local optimum can be derived within a reasonable runtime.Using a Danish hospital as our case study, the Markov chain model is statistically found to reflect occupancy of hospital beds by patients as a function of how hospital beds...... are distributed. Furthermore, our heuristic is found to efficiently derive the optimal solution. Applying our model to the hospital case, we found that relocation of daily arrivals can be reduced by 11.7% by re-distributing beds that are already available to the hospital....

  5. Impacting earthquake science and geoscience education: Educational programming to earthquake relocation

    Science.gov (United States)

    Carrick, Tina Louise

    This dissertation is comprised of four studies: three related to research on geoscience education and another seismological study of the South Island of New Zealand. The geoscience education research is grounded in 10 years of data collection and its implications for best practices for recruitment and retention of underrepresented minority students into higher education in the geosciences. The seismological component contains results from the relocation of earthquakes from the 2009 Dusky Sound Mw 7.8 event, South Island, New Zealand. In recent years, many have cited a major concern that U.S. is not producing enough STEM graduates to fit the forecasted economic need. This situation is exacerbated by the fact that underrepresented minorities are becoming a growing portion of the population, and people in these groups enter STEM careers at rates much smaller than their proportion of the populations. Among the STEM disciplines the Geosciences are the worst at attracting young people from underrepresented minorities. This dissertation reports on results the Pathways program at the University of Texas at El Paso Pathways which sought to create a geoscience recruitment and training network in El Paso, Texas to increase the number of Hispanic Americans students to attain higher degrees and increase the awareness of the geosciences from 2002-2012. Two elements of the program were a summer program for high school students and an undergraduate research program conducted during the academic year, called PREP. Data collected from pre- and post-surveys from the summer program showed statistically significant positive changes in attitudes towards the geosciences. Longitudinal data shows a strong positive correlation of the program with retention of participants in the geoscience pipeline. Results from the undergraduate research program show that it produced far more women and minority geoscience professionals than national norms. Combination of the institutional data, focus

  6. 41 CFR 102-74.255 - How must occupant evacuation or relocation be accomplished when there is immediate danger to...

    Science.gov (United States)

    2010-07-01

    ... evacuation or relocation be accomplished when there is immediate danger to persons or property, such as fire... danger to persons or property, such as fire, explosion or the discovery of an explosive device (not... immediate danger to persons or property, such as fire, explosion or the discovery of an explosive...

  7. Subduction zone in Java Island using primary wave tomography from Jacobian relocation method based on ak135 velocity model

    Science.gov (United States)

    Listyaningrum, Risca; Muhlis, Faid; Soesilo, Joko; Palupi, Indriati Retno

    2017-07-01

    The subduction zone occurs in Java Island analyzed based on data of tectonic earthquake. Earthquake data used is P wave velocity accessed from the ISC website from 1900-2013 years located along the Java Island. ISC is an organization that provides a variety of data tectonic earthquakes around the world, but the data used is the data before relocation. Relocation needs to reposition the hypocenter, so it can result a new position based on geological model. The relocation is using Jacobian's matrix and AK135 velocity model of P wave in each depth. The tomography process using FMTOMO software from result of new hypocenter represent the subsurface condition at a depth of 0-700 km. The result of hypocenter relocation is shifted horizontally to the southeast while vertically relatively shallow. The results obtained from the tomographic analysis of north-south section show the response of the velocity wave where high value shown in blue color as subduction zone and low value shown red color under volcanic as the partial melting. Tomographic 3D visualization displayed by Voxler software shows the different subduction in Java Island. Result of 3D analysis indicate that the subduction in West Java until Central Java relatively sloping than subduction in East Java.

  8. Influence of Intimate Partner Violence on Domestic Relocation in Metropolitan and Non-Metropolitan Young Australian Women

    NARCIS (Netherlands)

    Dillon, Gina; Hussain, Rafat; Kibele, Eva; Rahman, Saifur; Loxton, Deborah

    2016-01-01

    Data from a national, population-based longitudinal study of Australian women (26-34 years) were analyzed to investigate the association between domestic relocation and multiple explanatory factors, namely intimate partner violence (IPV), metropolitan versus non-metropolitan residence, education, in

  9. 75 FR 36677 - Notice of Relocation/Change of Address for the Bureau of Land Management, Office of Pipeline...

    Science.gov (United States)

    2010-06-28

    ... Bureau of Land Management Notice of Relocation/Change of Address for the Bureau of Land Management, Office of Pipeline Monitoring, Alaska State Office AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: The Bureau of Land Management (BLM), Office of Pipeline Monitoring, located at 411...

  10. Associations between parental deployment, relocation, and risky sexual behaviors among a clinic-based sample of military-dependent youth.

    Science.gov (United States)

    Hernandez, Belinda F; Peskin, Melissa F; Markham, Christine M; Burr, Jean; Roberts, Timothy; Tortolero, Susan

    2015-10-01

    Although sexual behaviors have been extensively studied among youth in general, they have been relatively understudied among military-dependent youth (MDY). Furthermore, the impact of unique military stressors, such as parental deployment and multiple relocations, on the sexual behaviors of MDY has not been assessed. In this pilot study, we estimated the prevalence of sexual behaviors among MDY, and examined the association between these behaviors and parental deployment and multiple relocations. Between June and September 2011, we recruited youth (N = 208; aged 15-19 years) who attended a military treatment facility in the southern United States, to complete a short, paper-based survey. We computed prevalence estimates and conducted Chi-square analyses, as well as logistic regression analyses, while adjusting for age, gender, and race/ethnicity. More than half (53.7 %) of the youth reported being sexually experienced, and many of these youth reported engaging in risky sexual behaviors. Parental deployment and multiple relocations were significantly associated only with having had sex in the past 3 months. Although with most sexual behaviors there was no significant association between parental deployment and multiple relocations, many MDY are sexually experienced and engage in risky sexual behaviors. MDY should thus be exposed to evidence-based strategies for sexually transmitted infection and pregnancy prevention, as well as provided with teen-friendly health care services and comprehensive sexual/reproductive health counseling.

  11. Influence of Intimate Partner Violence on Domestic Relocation in Metropolitan and Non-Metropolitan Young Australian Women

    NARCIS (Netherlands)

    Dillon, Gina; Hussain, Rafat; Kibele, Eva; Rahman, Saifur; Loxton, Deborah

    2016-01-01

    Data from a national, population-based longitudinal study of Australian women (26-34 years) were analyzed to investigate the association between domestic relocation and multiple explanatory factors, namely intimate partner violence (IPV), metropolitan versus non-metropolitan residence, education,

  12. 76 FR 47210 - Notices of Filing of Petitions for Food Additives and Color Additives; Relocation in the Federal...

    Science.gov (United States)

    2011-08-04

    ... HUMAN SERVICES Food and Drug Administration Notices of Filing of Petitions for Food Additives and Color Additives; Relocation in the Federal Register AGENCY: Food and Drug Administration, HHS. ACTION: Notice... petitions for food additives and color additives that are published in accordance with the Federal...

  13. Relocation of the Yellow River estuary in 1855 AD recorded in the sediment core from the northern Yellow Sea

    Science.gov (United States)

    Zhou, Xin; Jia, Nan; Cheng, Wenhan; Wang, Yuhong; Sun, Liguang

    2013-12-01

    Relocation of the Yellow River estuary has significant impacts on not only terrestrial environment and human activities, but also sedimentary and ecological environments in coastal seas. The responses of regional geochemical characteristics to the relocation event, however, have not been well studied. In the present study, we performed detailed geochemical elemental analyses of a sediment core from the northern Yellow Sea and studied their geochemical responses to the 1855 AD relocation of the Yellow River estuary. The results show that TOC/TN, Co/Al2O3, Cr/Al2O3, Ni/Al2O3 and Se/Al2O3 ratios all decreased abruptly after 1855 AD, and similar decreases are observed in the sediments of the mud area southwest off the Cheju Island. These abrupt changes are very likely caused by the changes in source materials due to the relocation of the Yellow River estuary from the southern Yellow Sea to the Bohai Sea, which the corresponding decreasing trends caused by the changes in main source materials from those transported by the Liaohe River, the Haihe River and the Luanhe River to those by the Yellow River. Because the events have precise ages recorded in historical archives, these obvious changes in elemental geochemistry of sediments can be used to calibrate age models of related coastal sea sediments.

  14. The Evolving Law of Disputed Relocation: constructing inner-city renewal practices in Shanghai, 1990-2005.

    Science.gov (United States)

    Shih, Mi

    2010-01-01

    The forceful pursuit of inner-city renewal in Shanghai since the early 1990s has to a great extent achieved spatial modernization, but at the same time it has given rise to increasing conflicts over residential relocation. Using law as a prism through which to examine the dialectic relationship between renewal practices and disputed relocation, this article argues that the series of unprecedented enactments in law that have taken place during this period have both paved the way for real estate market expansion and been a significant source of relocation disputes in Shanghai. Rather than viewing law as simply given and determinate, the article traces the regulatory regime's codification of property practices as a means of actively responding to the requirements of the real estate market. Under large-scale renewal practices, residents' legal rights of "return settlement" (huiban) in inner-city areas were largely denied in the early 1990s, before being effectively abolished by the adoption of monetary compensation for displacement in the 2000s. The evolving law on property practices has greatly shaped the process of disputed relocation while simultaneously posing a potential challenge to China's use of law for market-oriented development.

  15. The impact of facility relocation on patients' perceptions of ward atmosphere and quality of received forensic psychiatric care.

    Science.gov (United States)

    Alexiou, Eirini; Degl' Innocenti, Alessio; Kullgren, Anette; Wijk, Helle

    2016-08-01

    In recent years, large groups of forensic psychiatric patients have been relocated into new medium- and maximum-security forensic psychiatric facilities in Sweden, where a psychosocial care approach is embedded. From this perspective and on the assumption that physical structures affect the therapeutic environment, a prospective longitudinal study was designed to investigate the impact of the facility relocation of three forensic psychiatric hospitals on patients' perceptions of ward atmosphere and quality of received forensic psychiatric care. Participants were patients over 18 years of age sentenced to compulsory forensic psychiatric treatment. Data were obtained by validated questionnaires. Overall, 58 patients (78%) answered the questionnaires at baseline with a total of 25 patients (34%) completing follow-up 1 at six months and 11 patients (15%) completing follow-up 2, one year after relocation. Approximately two-thirds of the participants at all time-points were men and their age range varied from 18 to 69. The results of this study showed that poor physical environment features can have a severe impact on care quality and can reduce the possibilities for person-centered care. Furthermore, the study provides evidence that the patients' perceptions of person-centered care in forensic psychiatric clinics are highly susceptible to factors in the physical and psychosocial environment. Future work will explore the staff's perception of ward atmosphere and the possibilities to adapt a person-centered approach in forensic psychiatric care after facility relocation.

  16. Normal faulting in the Simav graben of western Turkey reassessed with calibrated earthquake relocations

    Science.gov (United States)

    Karasözen, Ezgi; Nissen, Edwin; Bergman, Eric A.; Johnson, Kendra L.; Walters, Richard J.

    2016-06-01

    Western Turkey has a long history of large earthquakes, but the responsible faults are poorly characterized. Here we reassess the past half century of instrumental earthquakes in the Simav-Gediz region, starting with the 19 May 2011 Simav earthquake (Mw 5.9), which we image using interferometric synthetic aperture radar and regional and teleseismic waveforms. This event ruptured a steep, planar normal fault centered at 7-9 km depth but failed to break the surface. However, relocated main shock and aftershock hypocenters occurred beneath the main slip plane at 10-22 km depth, implying rupture initiation in areas of low coseismic slip. These calibrated modern earthquakes provide the impetus to relocate and reassess older instrumental events in the region. Aftershocks of the 1970 Gediz earthquake (Mw 7.1) form a narrow band, inconsistent with source models that invoke low-angle detachment faulting, and may include events triggered dynamically by the unilateral main shock rupture. Epicenters of the 1969 Demirci earthquakes (Mw 5.9, 6.0) are more consistent with slip on the south dipping Akdağ fault than the larger, north dipping Simav fault. A counterintuitive aspect of recent seismicity across our study area is that the largest event (Mw 7.1) occurred in an area of slower extension and indistinct surface faulting, yet ruptured the surface, while recent earthquakes in the well-defined and more rapidly extending Simav graben are smaller (Mw <6.0) and failed to produce surface breaks. Though our study area bounds a major metamorphic core complex, there is no evidence for involvement of low-angle normal faulting in any of the recent large earthquakes.

  17. Multicriteria relocation analysis of an off-site radioactive monitoring network for a nuclear power plant.

    Science.gov (United States)

    Chang, Ni-Bin; Ning, Shu-Kuang; Chen, Jen-Chang

    2006-08-01

    Due to increasing environmental consciousness in most countries, every utility that owns a commercial nuclear power plant has been required to have both an on-site and off-site emergency response plan since the 1980s. A radiation monitoring network, viewed as part of the emergency response plan, can provide information regarding the radiation dosage emitted from a nuclear power plant in a regular operational period and/or abnormal measurements in an emergency event. Such monitoring information might help field operators and decision-makers to provide accurate responses or make decisions to protect the public health and safety. This study aims to conduct an integrated simulation and optimization analysis looking for the relocation strategy of a long-term regular off-site monitoring network at a nuclear power plant. The planning goal is to downsize the current monitoring network but maintain its monitoring capacity as much as possible. The monitoring sensors considered in this study include the thermoluminescence dosimetry (TLD) and air sampling system (AP) simultaneously. It is designed for detecting the radionuclide accumulative concentration, the frequency of violation, and the possible population affected by a long-term impact in the surrounding area regularly while it can also be used in an accidental release event. With the aid of the calibrated Industrial Source Complex-Plume Rise Model Enhancements (ISC-PRIME) simulation model to track down the possible radionuclide diffusion, dispersion, transport, and transformation process in the atmospheric environment, a multiobjective evaluation process can be applied to achieve the screening of monitoring stations for the nuclear power plant located at Hengchun Peninsula, South Taiwan. To account for multiple objectives, this study calculated preference weights to linearly combine objective functions leading to decision-making with exposure assessment in an optimization context. Final suggestions should be useful for

  18. Relocation of earthquakes at southwestern Indian Ocean Ridge and its tectonic significance

    Science.gov (United States)

    Luo, W.; Zhao, M.; Haridhi, H.; Lee, C. S.; Qiu, X.; Zhang, J.

    2015-12-01

    The southwest Indian Ridge (SWIR) is a typical ultra-slow spreading ridge (Dick et al., 2003) and further plate boundary where the earthquakes often occurred. Due to the lack of the seismic stations in SWIR, positioning of earthquakes and micro-earthquakes is not accurate. The Ocean Bottom Seismometers (OBS) seismic experiment was carried out for the first time in the SWIR 49 ° 39 'E from Jan. to March, 2010 (Zhao et al., 2013). These deployed OBS also recorded the earthquakes' waveforms during the experiment. Two earthquakes occurred respectively in Feb. 7 and Feb. 9, 2010 with the same magnitude of 4.4 mb. These two earthquakes were relocated using the software HYPOSAT based on the spectrum analysis and band-pass (3-5 Hz) filtering and picking up the travel-times of Pn and Sn. Results of hypocentral determinations show that there location error is decreased significantly by joined OBS's recording data. This study do not only provide the experiences for the next step deploying long-term wide-band OBSs, but also deepen understanding of the structure of SWIR and clarify the nature of plate tectonic motivation. This research was granted by the Natural Science Foundation of China (41176053, 91028002, 91428204). Keywords: southwest Indian Ridge (SWIR), relocation of earthquakes, Ocean Bottom Seismometers (OBS), HYPOSAT References:[1] Dick, H. J. B., Lin J., Schouten H. 2003. An ultraslow-spreading class of ocean ridge. Nature, 426(6965): 405-412. [2] Zhao M. H., et al. 2013. Three-dimensional seismic structure of the Dragon Flag oceanic core complex at the ultraslow spreading Southwest Indian Ridge (49°39' E). Geochemistry Geophysics Geosystems, 14(10): 4544-4563.

  19. Forensic odontology, part 4. Human bite marks.

    Science.gov (United States)

    Hinchliffe, J

    2011-04-23

    The aim of this paper is to give a brief overview of bite mark analysis: its usefulness and limitations. The study and analysis of such injuries is challenging and complex. The correct protocols for collection, management, preservation, analysis and interpretation of this evidence should be employed if useful information is to be obtained for the courts. It is now possible, with advances in digital technology, to produce more accurate and reproducible comparison techniques which go some way to preventing and reducing problems such as photographic distortions. Research needs to be continued to increase our knowledge of the behaviour of skin when bitten. However, when presented with a high quality bite mark showing good dental detail, and a limited, accessible number of potential biters, it can be extremely useful in establishing a link between the bitten person and the biter or excluding the innocent.

  20. EcoMark 2.0

    DEFF Research Database (Denmark)

    Guo, Chenjuan; Yang, Bin; Andersen, Ove;

    2015-01-01

    Eco-routing is a simple yet effective approach to substantially reducing the environmental impact, e.g., fuel consumption and greenhouse gas (GHG) emissions, of vehicular transportation. Eco-routing relies on the ability to reliably quantify the environmental impact of vehicles as they travel...... in a spatial network. The procedure of quantifying such vehicular impact for road segments of a spatial network is called eco-weight assignment. EcoMark 2.0 proposes a general framework for eco-weight assignment to enable eco-routing. It studies the abilities of six instantaneous and five aggregated models......, and experiments for assessing the utility of the impact models in assigning eco-weights. The application of EcoMark 2.0 indicates that the instantaneous model EMIT and the aggregated model SIDRA-Running are suitable for assigning eco-weights under varying circumstances. In contrast, other instantaneous models...

  1. The Bionic Clicker Mark I & II.

    Science.gov (United States)

    Magee, Elliott G; Ourselin, S; Nikitichev, Daniil; Vercauteren, T; Vanhoestenberghe, Anne

    2017-08-14

    In this manuscript, we present two 'Bionic Clicker' systems, the first designed to demonstrate electromyography (EMG) based control systems for educational purposes and the second for research purposes. EMG based control systems pick up electrical signals generated by muscle activation and use these as inputs for controllers. EMG controllers are widely used in prosthetics to control limbs. The Mark I (MK I) clicker allows the wearer to change the slide of a presentation by raising their index finger. It is built around a microcontroller and a bio-signals shield. It generated a lot of interest from both the public and research community. The Mark II (MK II) device presented here was designed to be a cheaper, sleeker, and more customizable system that can be easily modified and directly transmit EMG data. It is built using a wireless capable microcontroller and a muscle sensor.

  2. Ispra Mark-10 water splitting process

    Science.gov (United States)

    1975-01-01

    A thermochemical water splitting process, the Ispra Mark-10 chemical reaction cycle, was chosen for examining the possibility of using water to produce hydrogen on a large scale for fuel and major industrial chemical uses. The assumed energy source for the process is an HTGR (helium cooled). A process flow diagram, a material balance, and an energy balance were developed for the thermochemical reaction cycle. Principal reactions which constitute the cycle are included.

  3. Mucocele and pyocele with marked intracranial extension

    Energy Technology Data Exchange (ETDEWEB)

    Tsuchiya, Kazuhiro; Machida, Tohru; Iio, Masahiro

    1984-08-01

    Two cases are presented with frontal sinus pyocele and fronto-ethmoid sinus mucocele in which marked intracranial extension is shown. Their intracranial part appeared as a large biconvex mass, which showed iso or slightly low density homogeneously and had gross calcification in the posterior rim. The findings of the paranasal sinuses and the orbit in tomograms and CT scans are thought to be useful in the differential diagnosis of chronic subdural hematoma.

  4. Exhibition by Gozitan artist Mark Sagona

    OpenAIRE

    Calleja, Joseph

    2004-01-01

    Mark Sagona's exhibition, entitled "Recent Insights" was held at the Banca Giuratale in Victoria, Gozo between the 24th January and the 8th February 2004. It brought together twenty-four paintings, all produced in 2003 and the majority of which were realised in oil on canvas. The exhibition was curated by Dr Joseph Paul Cassar, and inaugurated by the Minister for Gozo, the Hon. Giovanna Debono.

  5. Laser treatment of stretch marks: preliminary results

    Science.gov (United States)

    Longo, Leonardo; Piccinetti, A. L.; Monache, G. D.; Botta, G.; Mancini, S.

    2000-06-01

    The best treatment of these stretch mark is still unknown. Some authors proposed the treatment with flash-lamp-pumped dye laser 585 nm, with fluence over 8 J/cm2. Reviewing our experiences on no-surgical effects of lasers in the various phases of the wound healing, including the re- epithelization, we would like to apply the no-surgical laser therapy treating the stretch marks of breast, abdomen and lumbo-sacral region. The goal is to inhibit the fibrous tissue metabolism, encouraging the destruction of the collagen fibers with inflammatory mechanism, and increasing the reconstitution of the superficial dermis layers. We treated five cases of stretch marks in women 22-35 years old, since May 1999, with a cycle of applications of double lasers, 511 and 577 nm, with energy of 20 Joule for spot, respecting the maximum thermal relaxation times of the skin. We waited two weeks interval between the applications. Results obtained after five applications are very positive, and we are encouraged to continue this experimentation.

  6. High efficiency metal marking with CO2 laser and glass marking with excimer laser

    DEFF Research Database (Denmark)

    Bastue, Jens; Olsen, Flemmming Ove

    1997-01-01

    with a thoroughly tested ray-tracing model is presented and compared with experimental results. Special emphasis is put on two different applications namely marking in metal with TEA-CO2 laser and marking in glass with excimer laser. The results are evaluated on the basis of the achievable energy enhancement......Today, mask based laser materials processing and especially marking is widely used. However, the energy efficiency in such processes is very low [1].This paper gives a review of the results, that may be obtained using the energy enhancing technique [1]. Results of simulations performed...

  7. Mark Raidpere näitused Pariisis ja Napolis / Mark Raidpere ; interv. Harry Liivrand

    Index Scriptorium Estoniae

    Raidpere, Mark

    2008-01-01

    Mark Raidpere videod "Vekovka", "Dedication / Pühendus", "Majestoso Mystico" näitusel Pariisis Michel Reini galeriis. Osaleb koos saksa fotograafi Sven Johnega näitusel Napolis. Kreekas Thessalonikis valminud filmist "1:1:1"

  8. Mark Raidpere näitused Pariisis ja Napolis / Mark Raidpere ; interv. Harry Liivrand

    Index Scriptorium Estoniae

    Raidpere, Mark

    2008-01-01

    Mark Raidpere videod "Vekovka", "Dedication / Pühendus", "Majestoso Mystico" näitusel Pariisis Michel Reini galeriis. Osaleb koos saksa fotograafi Sven Johnega näitusel Napolis. Kreekas Thessalonikis valminud filmist "1:1:1"

  9. Lessons learnt for Public Policy Maker from Relocation of Tsunami Affected Villagers in Thailand

    Science.gov (United States)

    Kamthonkiat, Daroonwan; Thuy Vu, Tuong

    2013-04-01

    The most notable tsunami in the Indian Ocean was the Indian Ocean Tsunami on 26 December 2004 caused by two strong earthquakes with the magnitudes of 9.3 and 7.3 on the Richter scale near Sumatra, Indonesia. It was the first tsunamis hit the Andaman Coast in southern Thailand, affected six provinces along the Andaman Coast, namely Phang Nga, Phuket, Satun, Krabi, Ranong, and Trang. The highest death toll (78.3% of the total 5,395 including unidentified bodies) and number of homeless victims were reported from Phang Nga Province. Following the December 2004 disaster, financial aids and land donations from many public and private sectors were used to support the renovation of damaged houses and new constructions in both same and new locations. Based on our field surveys and interviews with tsunami impact villagers in Phang Nga during 2005-2010, more than 1,600 houses were constructed in 29 locations and donated to tsunami homeless victims. Although the house supporting from government and other charities had fulfilled the homeless suffer of tsunami impact villagers, some socio-economic problems had revealed as summarized; 1)Many fishermen villages had illegally located in the conservative zones under the Department of Marine and Coastal Resource (DMCR), Ministry of Natural Resources and Environment (MONRE), though many villagers stayed in this area long ago. Aftermath of 2004 Indian Ocean tsunami, such illegally occupancy has no longer permitted in many locations. In addition, the governmental support especially for house construction and fishing equipments were priority approved for the villagers who occupied the land with certificate of ownership. Some fishermen villages were forced to relocate while a lot of villagers tried to stay illegally at the same locations. 2)Locations of new house donated by government and other charities had located far from the coastal area, moved to upper ground or rubber plantation area (outside tsunami inundated zone). Basic

  10. The Mark II detector for the SLC

    Energy Technology Data Exchange (ETDEWEB)

    Abrams, G.; Baden, A.R.; Boyer, J.; Butler, F.; Drell, P.S.; Fay, J.; Gidal, G.; Goldhaber, G.; Haggerty, J.; Harr, R.; Hearty, C.; Herrup, D.; Holmgren, S.O.; Jaffre, M.; Juricic, I.; Kadyk, J.A.; Kral, J.F.; Levi, M.E.; Lynch, G.R.; Richman, J.D.; Rouse, F.R.; Schaad, M.W.; Schmidke, W.B.; Schumm, B.A.; Trilling, G.H.; Wood, D.R. (Lawrence Berkeley Lab., CA (USA); California Univ., Berkeley (USA). Dept. of Physics); Adolphsen, C.E.; Burchat, P.R.; Dorfan, D.E.; Gatto, C.; Gomez Cadenas, J.J.; Gratta, G.; Heusch, C.A.; Kent, J.; King, M.; Koepke, L.; Labarga, L.; Litke, A.M.; Sadrozinski, H.F.W.; Schwarz, A.S.; Seiden, A.; Turala, M.; Watson, S.; Weisz, S.; Zaccardelli, C.; Von Zanthier, C. (California Univ., Santa Cruz (USA)); Akerlof, C.; Bonvicini, G.; Chapman, J.; Chmeissani, M.; Frey, R.; Gero, E.; Hong, S.J.; Koska, W.; Nitz, D.; Petradza, M.; Thun, R.; Tschirhart, R.; Veltman, H. (Michigan Univ., Ann Arbor (USA)); Alexander, J.P.; Ballam, J.; Barklow, T.; Bartelt, J.; De Boe

    1989-08-20

    The Mark II detector has been upgraded in preparation for its role as the first detector to take data at the Stanford Linear Collider. The new detector components include the central drift chamber, the time-of-flight system, the coil, the endcap electromagnetic calorimeters and the beam energy and luminosity measuring devices. There have also been improvements in detector hermeticity. All of the major components were installed for a test run at the PEP storage ring ({radical}s=29 GeV) in 1985. This paper describes the upgraded detector, including its trigger and data acquisition systems, and gives performance figures for its components. Future improvements are also discussed. (orig.).

  11. Kuosheng Mark III containment analyses using GOTHIC

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Ansheng, E-mail: samuellin1999@iner.gov.tw; Chen, Yen-Shu; Yuann, Yng-Ruey

    2013-10-15

    Highlights: • The Kuosheng Mark III containment model is established using GOTHIC. • Containment pressure and temperature responses due to LOCA are presented. • The calculated results are all below the design values and compared with the FSAR results. • The calculated results can be served as an analysis reference for an SPU project in the future. -- Abstract: Kuosheng nuclear power plant in Taiwan is a twin-unit BWR/6 plant, and both units utilize the Mark III containment. Currently, the plant is performing a stretch power uprate (SPU) project to increase the core thermal power to 103.7% OLTP (original licensed thermal power). However, the containment response in the Kuosheng Final Safety Analysis Report (FSAR) was completed more than twenty-five years ago. The purpose of this study is to establish a Kuosheng Mark III containment model using the containment program GOTHIC. The containment pressure and temperature responses under the design-basis accidents, which are the main steam line break (MSLB) and the recirculation line break (RCLB) accidents, are investigated. Short-term and long-term analyses are presented in this study. The short-term analysis is to calculate the drywell peak pressure and temperature which happen in the early stage of the LOCAs. The long-term analysis is to calculate the peak pressure and temperature of the reactor building space. In the short-term analysis, the calculated peak drywell to wetwell differential pressure is 140.6 kPa for the MSLB, which is below than the design value of 189.6 kPa. The calculated peak drywell temperature is 158 °C, which is still below the design value of 165.6 °C. In addition, in the long-term analysis, the calculated peak containment pressure is 47 kPa G, which is below the design value of 103.4 kPa G. The calculated peak values of containment temperatures are 74.7 °C, which is lower than the design value of 93.3 °C. Therefore, the Kuosheng Mark III containment can maintain the integrity after

  12. Method of marking an animal or plant

    Energy Technology Data Exchange (ETDEWEB)

    Guy, R.J.

    1994-04-27

    This patent describes a method of marking (non-human) animals and plants, involving the use of isotopes, in order to verify the authenticity of animal or plant products in subsequent use, for example free range meat, eggs or other foods. Most elements exist in more than one atomic form in nature. By altering the ratios of the stable isotopes of one or more elements naturally present in the plant or animal, it is possible to differentiate between true and counterfeit products. Altering the isotopic balance leaves the products suitability for human consumption unchanged. (UK).

  13. Mark Zuckerberg biography of an accidental billionaire

    CERN Document Server

    Melendez, Macie

    2012-01-01

    ABOUT THE BOOK Mark Zuckerberg is one of the world's youngest billionaires, thanks to his role in co-founding social networking site, Facebook. As Facebook has grown exponentially since its founding in 2004 (with 845 million monthly active users as of the end of December 2011 according to Facebook), Zuckerberg's popularity has also flown through the roof. Interesting on so many levels, Zuckerberg's quick rise to fame is one that the mass media and general public just can't get enough of. There's his Harvard education, his invention of one of the most popular Internet sites this world has ev

  14. MARK II end cap calorimeter electronics

    Energy Technology Data Exchange (ETDEWEB)

    Jared, R.C.; Haggerty, J.S.; Herrup, D.A.; Kirsten, F.A.; Lee, K.L.; Olson, S.R.; Wood, D.R.

    1985-10-01

    An end cap calorimeter system has been added to the MARK II detector in preparation for its use at the SLAC Linear Collider. The calorimeter uses 8744 rectangular proportional counter tubes. This paper describes the design features of the data acquisition electronics that has been installed on the calorimeter. The design and use of computer-based test stands for the amplification and signal-shaping components is also covered. A portion of the complete system has been tested in a beam at SLAC. In these initial tests, using only the calibration provided by the test stands, a resolution of 18%/..sqrt..E was achieved.

  15. Citation Analysis with Mark-and-Recapture

    CERN Document Server

    Loe, Chuan Wen

    2015-01-01

    Mark-and-Recapture is a methodology from Population Biology to estimate the number of a species without counting every individual. This is done by multiple samplings of the species using traps and discounting the instances that were caught repeated. In this paper we show that this methodology is applicable for citation analysis as it is also not feasible to count all the relevant publications of a research topic. In addition this estimation also allows us to propose a stopping rule for researchers to decide how far one should extend their search for relevant literature.

  16. Marking Space and Making Place in Barcelona

    DEFF Research Database (Denmark)

    Hau, Mark Friis

    2016-01-01

    of Catalonia problematizes the role of ‘the city’ in the Catalan independence movement. Through the actors’ narrative inscriptions of certain spaces as Catalan and active markings of the cityscape, the city itself helps to orient understandings of national identity. Visual cues, both in architecture...... ideas of nation and state are encountered and contested in Barcelona through activists’ spatial engagements, exploring how the city, the nation, and the political are connected in Catalonia. The position of Barcelona in activists’ narratives as both ‘less Catalan’ and as the undeniable capital...

  17. The positive behavioral momentum of Mark Ylvisaker.

    Science.gov (United States)

    Turkstra, Lyn S

    2010-08-01

    Mark Ylvisaker inspired many people to believe they had the skills to help children and adults with brain injury live a meaningful life. He was thoroughly multidisciplinary in his approach, but also felt strongly that communication was the cornerstone of effective behavior management and that speech-language pathologists could make a unique contribution in the everyday lives of individuals with cognitive-communication disorders. This article recognizes his profound influence on the author's research, teaching, and clinical practice and was written in the spirit of paying forward the knowledge he shared.

  18. 33 CFR 62.27 - Safe water marks.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Safe water marks. 62.27 Section... UNITED STATES AIDS TO NAVIGATION SYSTEM The U.S. Aids to Navigation System § 62.27 Safe water marks. Safe water marks indicate that there is navigable water all around the mark. They are often used to...

  19. 14 CFR 45.31 - Marking of export aircraft.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Marking of export aircraft. 45.31 Section 45.31 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT IDENTIFICATION AND REGISTRATION MARKING Nationality and Registration Marks § 45.31 Marking of export aircraft. A...

  20. 19 CFR 134.45 - Approved markings of country name.

    Science.gov (United States)

    2010-04-01

    ... OF THE TREASURY COUNTRY OF ORIGIN MARKING Method and Location of Marking Imported Articles § 134.45 Approved markings of country name. (a) Language. (1) Except as otherwise provided in paragraph (a)(2) of this section, the markings required by this part shall include the full English name of the country...

  1. 46 CFR 108.646 - Marking of stowage locations.

    Science.gov (United States)

    2010-10-01

    ... AND EQUIPMENT Equipment Markings and Instructions § 108.646 Marking of stowage locations. (a) Containers, brackets, racks, and other similar stowage locations for lifesaving equipment, must be marked... 46 Shipping 4 2010-10-01 2010-10-01 false Marking of stowage locations. 108.646 Section...

  2. Characterization of the relocated and dispersed fuel in the Halden reactor project LOCA tests based on gamma scan data

    Energy Technology Data Exchange (ETDEWEB)

    Brankov, Vladimir, E-mail: vladimir.brankov@psi.ch [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne (Switzerland); Khvostov, Grigori; Mikityuk, Konstantin [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Pautz, Andreas [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne (Switzerland); Wiesenack, Wolfgang [Institutt For Energiteknikk OECD Halden Reactor Project, P.O. Box 173, Halden 1751 (Norway)

    2016-04-15

    Highlights: • We propose method to estimate dispersed fuel based on gamma scan data. • Analysis to determine the origin of relocated and dispersed fuel in Halden LOCA tests. • Useful data is gathered for code validation. • Suggestions are discussed to improve the quality of gamma scan data at Halden. • Dispersed and relocated material is a mixture of fuel from pellet periphery and bulk. - Abstract: The on-going Loss-of-Coolant Accident (LOCA) test program at the OECD Halden Reactor Project (HRP) conducts in-house gamma scanning as standard post-irradiation examination (PIE) procedure on Light Water Reactor (LWR) fuel rods. One of the primary objectives of the program is to investigate fuel relocation into the balloon region and fuel dispersal through the cladding rupture opening after burst. A simple model called Gamma Transport Model was formulated for the purpose of interpretation of fuel relocation based on the gamma scan data. Fuel relocation may have a strong effect on the linear heat generation rate at the balloon due to, firstly, increase in linear fuel density, and secondly due to differences in burn-up and local heat generation rate at the periphery and bulk of the pellet. For this analysis, a pair of short-lived isotopes with very different fission product yields for {sup 235}U and {sup 239}Pu is selected from the gamma scan spectrum. The intention is to use the difference in the ratio of their concentrations in the balloon region to qualitatively make conclusion on the fuel relocation. As a separate outcome, the same analysis can be applied to the dispersed fuel region and to draw conclusion on its origin (pellet rim or bulk). The Gamma Transport Model is validated against a special (non-destructive) case from the Halden LOCA test program and then applied for the analysis of selected tests. In addition, a methodology is presented for estimation of the amount of dispersed fuel from the LOCA tests based on the gamma scan data. Currently, at

  3. Fault geometry of Vesuvius earthquakes from revised tomographic models and accurate earthquake relocations

    Science.gov (United States)

    Scarpa, R.; del Pezzo, E.; Bianco, F.; Saccorotti, G.; Tronca, F.

    2003-04-01

    A high resolution P-wave image of Mt. Vesuvius edifice has been derived from simultaneous inversion of travel times and hypocentral parameters of local earthquakes, land based shots and small aperture array data. The resulting image is resolved to 300-500 m block size. The relocated local seismicity appears to extend down to 5 km below the central crater, distributed in a major cluster, centered at 3 km below the central crater and in a minor group, with diffuse hypocenters inside the volcanic edifice. The two clusters are separated by an anomalously high Vp region at around 1 km depth. A zone with high Vp/Vs in the upper layers is interpreted as produced by the presence of intense fluid circulation. The highest energy quakes (up to M=3.6) are located in the deeper cluster, in a high P-wave velocity zone. Our results favor an interpretation in terms of absence of shallow magma reservoirs. Fault plane solutions, obtained in the hypothesis of double couple mechanism, show unstable solutions with no preferential trend. This is possibly due to the unfavourable signal to noise ratio affecting the first motion pulse direction estimates. The occurrence of similar earthquakes (multiplets) greatly helps in evidencing the trend of the main faults of the investigated area. We grouped similar earthquakes into several different families using the Equivalence Class approach. For each family, we use interpolated correlation analyses to estimate the time shifts among the different members of the family with respect to a principal event selected as the master one. Least-squares adjustment of arrival times provide consistency of these estimates throughout the different members of the cluster. This refined set of arrival times is then used to relocate events belonging to individual clusters using a non-linear, probabilistic technique acting on the 3-D heterogeneous earth structure. The high similarity of waveforms for events belonging to different families is associated to similar

  4. The Five Marks of the Mental

    Science.gov (United States)

    Pernu, Tuomas K.

    2017-01-01

    The mental realm seems different to the physical realm; the mental is thought to be dependent on, yet distinct from the physical. But how, exactly, are the two realms supposed to be different, and what, exactly, creates the seemingly insurmountable juxtaposition between the mental and the physical? This review identifies and discusses five marks of the mental, features that set characteristically mental phenomena apart from the characteristically physical phenomena. These five marks (intentionality, consciousness, free will, teleology, and normativity) are not presented as a set of features that define mentality. Rather, each of them is something we seem to associate with phenomena we consider mental, and each of them seems to be in tension with the physical view of reality in its own particular way. It is thus suggested how there is no single mind-body problem, but a set of distinct but interconnected problems. Each of these separate problems is analyzed, and their differences, similarities and connections are identified. This provides a useful basis for future theoretical work on psychology and philosophy of mind, that until now has too often suffered from unclarities, inadequacies, and conflations. PMID:28736537

  5. MARKS OF ETHNICITY IN PURPLE HIBISCUS TRANSLATION

    Directory of Open Access Journals (Sweden)

    Fernanda de Oliveira Müller

    2016-10-01

    Full Text Available This study gives an analysis of the English – Brazilian Portuguese translation of Chimamanda Ngozi Adichie’s novel, Purple Hibiscus, made by Julia Romeu. It is an attempt to analyze how traces of ethnic identities marked in the source text are reproduced in the Brazilian version Hibisco Roxo, published in 2011. Initially, is a brief biography of the writer is presented together with her history towards the construction of a new paradigm for the literature about Africa and Nigeria. Adichie challenges Western stereotypes about that continent, which tend to report poverty, war and disease scenarios. Secondly, a summary of the story was made and the main characters were described. Thirdly, a collection of recorded words and phrases in the Igbo language was compiled from the original text and an analysis of the translation of those terms into Brazilian Portuguese was performed. Afterwards, the concept of ethnicity described by the sociologist Anthony Giddens was presented. Based on that concept, it was concluded that the terms previously selected could be considered as marks of ethnicity, reflecting the presence of the Igbo ethnic group in the British colonial culture. Finally, taking Antoine Berman’s proposition for an ethical translation, which embraces the foreign and rejects ethnocentrism, the conclusion to be drawn is that the translator’s option to keep Igbo terms in her work respected the author’s manifest intention of, through her work, showing the readers from other countries a bit of Nigeria’s culture and history.

  6. The Five Marks of the Mental

    Directory of Open Access Journals (Sweden)

    Tuomas K. Pernu

    2017-07-01

    Full Text Available The mental realm seems different to the physical realm; the mental is thought to be dependent on, yet distinct from the physical. But how, exactly, are the two realms supposed to be different, and what, exactly, creates the seemingly insurmountable juxtaposition between the mental and the physical? This review identifies and discusses five marks of the mental, features that set characteristically mental phenomena apart from the characteristically physical phenomena. These five marks (intentionality, consciousness, free will, teleology, and normativity are not presented as a set of features that define mentality. Rather, each of them is something we seem to associate with phenomena we consider mental, and each of them seems to be in tension with the physical view of reality in its own particular way. It is thus suggested how there is no single mind-body problem, but a set of distinct but interconnected problems. Each of these separate problems is analyzed, and their differences, similarities and connections are identified. This provides a useful basis for future theoretical work on psychology and philosophy of mind, that until now has too often suffered from unclarities, inadequacies, and conflations.

  7. Precise Hypocenter Relocation of Microearthquakes in the Torfajökull Volcanic System, Iceland

    Science.gov (United States)

    Lippitsch, R.; White, R. S.; Soosalu, H.

    2003-12-01

    The Torfajökull volcanic system is one of about 30 active volcanoes comprising the neovolcanic zones of Iceland. It is located at the rift-transform junction between the Eastern Volcanic Zone and the South Iceland Seismic Zone. The central volcanic part of the system is the largest silicic centre in Iceland with a caldera of about 12 km diameter. It's high-temperature geothermal system is one of the most powerful in Iceland. Torfajökull is the source of persistent seismicity, where both high- and low-frequency earthquakes occur. To study the microseismicity of the volcanic area in detail a temporary array of 20 broad-band seismic stations was deployed between May and November 2002. These temporary stations were embedded in the permanent South Iceland Lowland (SIL) network, and data from nine adjacent SIL-stations were included in the study. A 'minimum one-dimensional velocity model' with station corrections was computed for earthquake relocation by inverting manually picked P- and S- wave arrival times from events occurring in the Torfajökull volcanic centre, beneath Myrdalsjökull glacier south of the temporary array, and in the South Iceland Seismic Zone in the west. High-frequency earthquakes from the Torfajökull volcanic centre were then relocated using the program NonLinLoc, which calculates a non-linear, probabilistic solution to the earthquake location problem. From several hundred earthquakes in the Torfajökull area, 122 were well locatable (gap < 180 degrees, more than 10 observations). Subsequently, we correlated the waveforms of this sub-dataset (around 2000 obseravtions) to define linked events, calculated the relative travel time difference between event pairs, and solved for the hypocentral separation between these events with HypoDD. The resulting high-resolution pattern shows a tighter clustering in epicenter and focal depth when compared to original locations. All earthquakes are located beneath the caldera with hypocenters between 1 and 6 km

  8. Evaluation of copper for divider subassembly in MCO Mark IA and Mark IV scrap fuel baskets

    Energy Technology Data Exchange (ETDEWEB)

    Graves, C.E.

    1997-09-29

    The K Basin Spent Nuclear Fuel (SNF) Project Multi-Canister Overpack (MCO) subprojection eludes the design and fabrication of a canister that will be used to confine, contain, and maintain fuel in a critically safe array to enable its removal from the K Basins, vacuum drying, transport, staging, hot conditioning, and interim storage (Goldinann 1997). Each MCO consists of a shell, shield plug, fuel baskets (Mark IA or Mark IV), and other incidental equipment. The Mark IA intact and scrap fuel baskets are a safety class item for criticality control and components necessary for criticality control will be constructed from 304L stainless steel. It is proposed that a copper divider subassembly be used in both Mark IA and Mark IV scrap baskets to increase the safety basis margin during cold vacuum drying. The use of copper would increase the heat conducted away from hot areas in the baskets out to the wall of the MCO by both radiative and conductive heat transfer means. Thus copper subassembly will likely be a safety significant component of the scrap fuel baskets. This report examines the structural, cost and corrosion consequences associated with using a copper subassembly in the stainless steel MCO scrap fuel baskets.

  9. Hypocenters relocation using double-difference method around Molucca Collision Zone

    Science.gov (United States)

    Yulianto, Yuhanas; Nugraha, Andri Dian; Wiyono, Wandono Samsul

    2017-07-01

    Eastern Indonesia is situated in a very complicated tectonic settings due to the converging of three major plates. Those plates do not have a clear boundary between each other. The boundary zone is covered by many microplates which converging or subducting to each other or create a large dimension of transform fault. Consequently, the region has a relatively higher seismic activity compared to others region in Indonesia, or even we can say, in the world. In this study, we attempt to achieve better hypocenter locations with double-difference method using local earthquake events compiled by MCGA of Indonesia. We selected 3,666 events from 42 stations for time periods of January 2010 to December 2015 which occurred in area around Molucca Collision Zone. Our results show better hypocenter location according to the RMS of time residual shifting. The most significant changes are in the shallow events where fix-depth effect had been removed. Overall, the relocated hypocenter locations show a better distribution to represent the tectonic setting.

  10. Using Student Engagement to Relocate Ethics to the Core of the Engineering Curriculum.

    Science.gov (United States)

    Sunderland, Mary E

    2013-04-18

    One of the core problems with engineering ethics education is perceptual. Although ethics is meant to be a central component of today's engineering curriculum, it is often perceived as a marginal requirement that must be fulfilled. In addition, there is a mismatch between faculty and student perceptions of ethics. While faculty aim to communicate the nuances and complexity of engineering ethics, students perceive ethics as laws, rules, and codes that must be memorized. This paper provides some historical context to better understand these perceptual differences, and suggests that curriculum constraints are important contributing factors. Drawing on the growing scholarship of student engagement approaches to pedagogy, the paper explores how students can be empowered to effect change in the broader engineering curriculum through engineering ethics. The paper describes a student engagement approach to pedagogy that includes students as active participants in curriculum design-a role that enables them to critically reflect about why ethics is a requirement. Including students in the process of curriculum design leads students to reframe ethics as an integrative tool with the capacity to bring together different engineering departments and build bridges to non-engineering fields. This paper argues that students can and should play an active and important role in relocating ethics from the periphery to the core of the engineering curriculum.

  11. (Relocating (Identity With(in Politicized (Representation of Fe/Male Body in Kamala Das’ Poetry

    Directory of Open Access Journals (Sweden)

    Sharmin Sultana

    2016-04-01

    Full Text Available This paper is going to argue that the selected poems of renowned Indian poet Kamala Das are inclined to relocate both feminine and masculine identity through the politicized representation of body.  Kamala Das’ representation of body in her poems has always been viewed as a medium of re-historicizing the pain, sufferings, and psychological trauma that a woman goes through in a patriarchal society.  Though apparently female body seems to be submissive under patriarchal dominance but this paper reveals how female body in Das’ poems acts as a powerful agent over the male body. The objective of this paper is to analyze and evaluate kamala Das’ representation of body to understand the gender reality in a patriarchal society, to question the existing discourse of sexed/gendered identity, to find a new way of viewing to both female and male body. Echoing Beauvoir, Judith Butler and Hall, this paper is going to analyze how Kamala Das represents body as an important factor in her poems to fight back the normative concept of identity based on patriarchal sex and/or gender stereotypes. Keywords: identity, body, sex/gender, performativity, representation

  12. Solving the dynamic ambulance relocation and dispatching problem using approximate dynamic programming.

    Science.gov (United States)

    Schmid, Verena

    2012-06-16

    Emergency service providers are supposed to locate ambulances such that in case of emergency patients can be reached in a time-efficient manner. Two fundamental decisions and choices need to be made real-time. First of all immediately after a request emerges an appropriate vehicle needs to be dispatched and send to the requests' site. After having served a request the vehicle needs to be relocated to its next waiting location. We are going to propose a model and solve the underlying optimization problem using approximate dynamic programming (ADP), an emerging and powerful tool for solving stochastic and dynamic problems typically arising in the field of operations research. Empirical tests based on real data from the city of Vienna indicate that by deviating from the classical dispatching rules the average response time can be decreased from 4.60 to 4.01 minutes, which corresponds to an improvement of 12.89%. Furthermore we are going to show that it is essential to consider time-dependent information such as travel times and changes with respect to the request volume explicitly. Ignoring the current time and its consequences thereafter during the stage of modeling and optimization leads to suboptimal decisions.

  13. Farming the Desert: agriculture in the World War II-era Japanese-American relocation centers.

    Science.gov (United States)

    Lillquist, Karl

    2010-01-01

    In 1942 over 110,000 Japanese Americans were evacuated from the West Coast to ten inland, barbed wire-enclosed relocation centers in the name of national security. Agriculture was a key component of the eight arid to semi-arid centers located in the western United States. Each center's agricultural program included produce for human consumption, feed crops, and livestock. Some centers also grew seed, ornamental, and war crops. Evacuees raised and consumed five types of livestock and sixty-one produce varieties, including many traditional foods. Seasonal surpluses were preserved, shipped to other centers, or sold on the open market. Short growing seasons, poor soils, initially undeveloped lands, pests, equipment shortages, and labor issues hampered operations. However, imprisoned evacuee farmers proved that diverse agricultural programs could succeed in the harsh settings primarily because of labor-intensive farming methods, ingenuity, and the large markets provided by the centers. These agricultural programs played major roles in feeding, providing meaningful employment, and preparing evacuees for life outside the centers, and readied lands for post-war "homesteaders."

  14. Problem of relocation of citizens from unfit housing facilities exemplified by the regions

    Directory of Open Access Journals (Sweden)

    Unacheva Lyana Ruslanovna

    2016-12-01

    Full Text Available The problems of relocation of citizens from unfit and slum dwellings are considered. Residential property market analysis illustrating a house construction attenuation was performed. The problems of provision of quality and equivalent housing are touched, and the reasons for inaccessibility thereof are illustrated. Measures taken for control of quality of the provided houses are considered. Attention is drawn to development problems of the North Caucasus as an example of one of the problematic regions. For the system solution of the erected housing quality issue it is planned to introduce this year the obligation for a self-regulatory organization to have a permit for design and construction of low-rise buildings. It is necessary to focus on the quality of housing, on elimination of corruption, improvement of work of the body for the housing stock price formation, and the local self-governing authorities. The carried-out measures with due attention of regions’ authorities will enable to keep priority rates of the unfit dwelling liquidation and fulfil the general tasks set by the President and the RF Government.

  15. Learning in an exotic social wasp while relocating a food source.

    Science.gov (United States)

    Lozada, Mariana; D'Adamo, Paola

    2014-01-01

    In this paper we review several studies on Vespulagermanica behavioral plasticity while relocating a food source in natural environments. This exotic social wasp, which has become established in many parts of the world, displays diverse cognitive abilities when foraging. Given its successful invasiveness worldwide, our initial hypothesis was that this species has great behavioral plasticity, which enables it to face environmental uncertainty. In our work we have analyzed foraging behavior associated with undepleted resources. Throughout several experiments, rapid learning was observed in this species; after few learning experiences they associate diverse contextual cues with a food source. However, by exploring wasp behavior when food suddenly disappeared, either because it had been removed or displaced, we found that they continued searching over a no longer rewarding site for a considerable period of time, suggesting that past experience can hinder new learning. Particularly surprising is the fact that when food was displaced nearby, wasps persisted in searching over the empty dish, ignoring the presence of food close by. We propose that this species could be a suitable model for studying cognitive plasticity in relation to environmental uncertainty.

  16. An interview with Mark G. Hans.

    Science.gov (United States)

    Hans, Mark G; Nojima, Matilde da Cunha Gonçalves

    2014-01-01

    It is a great honor to conduct an interview with Professor Mark G. Hans, after following his outstanding work ahead of the Bolton-Brush Growth Study Center and the Department of Orthodontics at the prestigious Case Western Reserve School of Dental Medicine (CWRU) in Cleveland, Ohio. Born in Berea, Ohio, Professor Mark Hans attended Yale University in New Haven, CT, and earned his Bachelor of Science Degree in Chemistry. Upon graduation, Dr. Hans received his DDS and Masters Degree of Science in Dentistry with specialty certification in Orthodontics at Case Western Reserve University. During his education, Dr. Hans’ Master’s Thesis won the Harry Sicher Award for Best Research by an Orthodontic Student and being granted a Presidential Teaching Fellowship. As one of the youngest doctors ever certified by the American Board of Orthodontics, Dr. Hans continues to maintain his board certification. He has worked through academics on a variety of research interests, that includes the demographics of orthodontic practice, digital radiographic data, dental and craniofacial genetics, as obstructive sleep apnea syndrome, with selected publications in these fields. One of his noteworthy contributions to the orthodontic literature came along with Dr. Donald Enlow on the pages of “Essentials of Facial Growth”, being reference on the study of craniofacial growth and development. Dr. Mark Hans’s academic career is linked to CWRU, recognized as the renowned birthplace of research on craniofacial growth and development, where the classic Bolton-Brush Growth Study was historically set. Today, Dr. Hans is the Director of The Bolton-Brush Growth Study Center, performing, with great skill and dedication, the handling of the larger longitudinal sample of bone growth study. He is Associate Dean for Graduate Studies, Professor and Chairman of the Department of Orthodontics, working in clinical and theoretical activities with students of the Undergraduate Course from the School of

  17. Marking Streets to Improve Parking Density

    CERN Document Server

    Xu, Chao

    2015-01-01

    Street parking spots for automobiles are a scarce commodity in most urban environments. The heterogeneity of car sizes makes it inefficient to rigidly define fixed-sized spots. Instead, unmarked streets in cities like New York leave placement decisions to individual drivers, who have no direct incentive to maximize street utilization. In this paper, we explore the effectiveness of two different behavioral interventions designed to encourage better parking, namely (1) educational campaigns to encourage parkers to "kiss the bumper" and reduce the distance between themselves and their neighbors, or (2) painting appropriately-spaced markings on the street and urging drivers to "hit the line". Through analysis and simulation, we establish that the greatest densities are achieved when lines are painted to create spots roughly twice the length of average-sized cars. Kiss-the-bumper campaigns are in principle more effective than hit-the-line for equal degrees of compliance, although we believe that the visual cues of...

  18. Marked Seizure Reduction after MCT Supplementation

    Directory of Open Access Journals (Sweden)

    Raed Azzam

    2013-01-01

    Full Text Available We report the case of a 43-year-old man with history of nonsurgical partial epilepsy who previously failed multiple trials of antiepileptic drugs. Medium-chain triglycerides (MCT were added to his regular diet in the form of pure oil. Subsequently, his seizure frequency was markedly reduced from multiple daily seizures to one seizure every four days. His seizures recurred after transient discontinuation of MCT over a period of ten days. His seizure improvement was achieved at a dose of four tablespoons of MCT twice daily with no reported side effects. He developed significant diarrhea and flatulence at higher doses. We conclude that MCT oil supplementation to regular diet may provide better seizure control in some patients. MCT oil supplementation may be a more tolerable alternative to the standard ketogenic diet.

  19. TRIGA Mark-III reactor dismantling program

    Energy Technology Data Exchange (ETDEWEB)

    Chung, U. S.; Lee, B. J.; Paik, S. T.; Jung, K. J. [TRIGA Research Reactor D and D Project Team, Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1999-07-01

    The activation assessment of the main parts of the TRIGA Mark-III (KRR-2) was estimated to effectively dismantle the activated and contaminated areas. All of the method and the order for decommissioning the KRR-2 have been chosen as a result of the examination of the physical structure and radiological conditions of the reactor component. These decommissioning methods and orders were reviewed as part of the Hazard and Operability (HAZOP) studies for the project. Radiological assessment is also done to protect the workers and the environment from the dismantling work. License documents were submitted to the Ministry of Science and Technology (MOST) at the end of 1998. Practical work of the D and D will start at the end of 1999 once the government issues the license. Radiation protection plan was also set up to control the workers and environment. This paper summarized the main lines of those studies. (author)

  20. Mark IVA DSN 26-meter Subnet

    Science.gov (United States)

    Gordon, D. D.

    1984-01-01

    The Office of Space Tracking and Data Systems' Networks Consolidation Program (NCP), managed by the Jet Propulsion Laboratory (JPL), includes the implementation of a 26-meter Tracking and Communications Subnet as a part of the Mark IV A Deep Space Network (DSN). The incorporatin of this subnet into the DSN will contribute to the NCP goal of consolidating the two NASA ground tracking networks into one tracking network. The 26-meter Tracking and Communication Subnet was designed to provide the capability to support, at each Deep Space Communication Complex, the tracking and data communication requirements of the earth-orbital missions that cannot be supported by the Tracking and Data Relay Satellite System when it becomes operational. Implementation activities and planned capabilities of the subnet are discussed.

  1. An interview with Mark G. Hans

    Science.gov (United States)

    Bolognese, Ana Maria; Palomo, Juan Martin; Miyashita, Kunihiko; Nojima, Lincoln Issamu; Nojima, Matilde da Cunha Gonçalves

    2014-01-01

    It is a great honor to conduct an interview with Professor Mark G. Hans, after following his outstanding work ahead of the Bolton-Brush Growth Study Center and the Department of Orthodontics at the prestigious Case Western Reserve School of Dental Medicine (CWRU) in Cleveland, Ohio. Born in Berea, Ohio, Professor Mark Hans attended Yale University in New Haven, CT, and earned his Bachelor of Science Degree in Chemistry. Upon graduation, Dr. Hans received his DDS and Masters Degree of Science in Dentistry with specialty certification in Orthodontics at Case Western Reserve University. During his education, Dr. Hans' Master's Thesis won the Harry Sicher Award for Best Research by an Orthodontic Student and being granted a Presidential Teaching Fellowship. As one of the youngest doctors ever certified by the American Board of Orthodontics, Dr. Hans continues to maintain his board certification. He has worked through academics on a variety of research interests, that includes the demographics of orthodontic practice, digital radiographic data, dental and craniofacial genetics, as obstructive sleep apnea syndrome, with selected publications in these fields. One of his noteworthy contributions to the orthodontic literature came along with Dr. Donald Enlow on the pages of "Essentials of Facial Growth", being reference on the study of craniofacial growth and development. Dr. Mark Hans's academic career is linked to CWRU, recognized as the renowned birthplace of research on craniofacial growth and development, where the classic Bolton-Brush Growth Study was historically set. Today, Dr. Hans is the Director of The Bolton-Brush Growth Study Center, performing, with great skill and dedication, the handling of the larger longitudinal sample of bone growth study. He is Associate Dean for Graduate Studies, Professor and Chairman of the Department of Orthodontics, working in clinical and theoretical activities with students of the Undergraduate Course from the School of Dental

  2. Flower bats (Glossophaga soricina and fruit bats (Carollia perspicillata rely on spatial cues over shapes and scents when relocating food.

    Directory of Open Access Journals (Sweden)

    Gerald G Carter

    Full Text Available BACKGROUND: Natural selection can shape specific cognitive abilities and the extent to which a given species relies on various cues when learning associations between stimuli and rewards. Because the flower bat Glossophaga soricina feeds primarily on nectar, and the locations of nectar-producing flowers remain constant, G. soricina might be predisposed to learn to associate food with locations. Indeed, G. soricina has been observed to rely far more heavily on spatial cues than on shape cues when relocating food, and to learn poorly when shape alone provides a reliable cue to the presence of food. METHODOLOGY/PRINCIPAL FINDINGS: Here we determined whether G. soricina would learn to use scent cues as indicators of the presence of food when such cues were also available. Nectar-producing plants fed upon by G. soricina often produce distinct, intense odors. We therefore expected G. soricina to relocate food sources using scent cues, particularly the flower-produced compound, dimethyl disulfide, which is attractive even to G. soricina with no previous experience of it. We also compared the learning of associations between cues and food sources by G. soricina with that of a related fruit-eating bat, Carollia perspicillata. We found that (1 G. soricina did not learn to associate scent cues, including dimethyl disulfide, with feeding sites when the previously rewarded spatial cues were also available, and (2 both the fruit-eating C. perspicillata and the flower-feeding G. soricina were significantly more reliant on spatial cues than associated sensory cues for relocating food. CONCLUSIONS/SIGNIFICANCE: These findings, taken together with past results, provide evidence of a powerful, experience-independent predilection of both species to rely on spatial cues when attempting to relocate food.

  3. The Experience of Miners Relocated to Alternative Positions due to Silicosis in the Andean of CODELCO, Chile, 2010.

    Science.gov (United States)

    Delgado, Diemen; Aguilera, Maria de Los Angeles; Delgado, Fabian; Rug, Ani

    2012-06-01

    To understand the personal experiences of mine workers that have experienced job relocation due to silicosis at the Andina Division of Corporación Nacional del Cobre (CODELCO), Chile. The purpose of the study was to provide useful information for the development of new local, business and public policies for the care of workers with silicosis. A qualitative study based on a practical case study of 5 workers. The information was collected by means of structured individual interviews. The method of analysis was phenomenology. The corporal axis was the most commented upon. It included awareness of the illness, body pains, fatigue, and antagonistic mood disorders (sadness, or the difficulty in finding meaning in life). As far as personal relationships, there was evidence of strong relationships with family, coworkers and friends, as well as extended family. Over all, the experience of relocation was positive with periods of impatience and uncertainty. The job reassignment provided a new and pleasant context for the relocated workers and in the process improved their perception of their quality of life. A multidisciplinary team should attend mine workers relocated because of silicosis by addressing the mental and physical aspects of their disease, along with the integral participation of close family members. It is suggested that this investigation be maintain over time to record the personal experiences in the medium-term, adding new cases with the intention of shedding more light on the phenomenon being studied. As a preventive measure, continual workshops are needed on the proper use of respiratory protection in addition, a group of monitors is required.

  4. Acute stress disorder and major depressive disorder in flood victims from Tingo Maria: prevlence and the effect of relocating

    OpenAIRE

    2008-01-01

    Objectives. To determine the prevalence of acute stress disorder (ASD) and comorbidity with major depressive disorder (ASD+MDD) in flood victims from Tingo María, Huánuco (Peruvian central jungle), 20 days after the traumatic event. Material and methods: One hundred and twenty injured (people relocated after disaster) and 110 affected (people living in their own homes) were surveyed and compared. Was applied to structured clinical interview for disorders axis I from DSM-IV, clinical versi...

  5. Correlative imaging across microscopy platforms using the fast and accurate relocation of microscopic experimental regions (FARMER) method

    Science.gov (United States)

    Huynh, Toan; Daddysman, Matthew K.; Bao, Ying; Selewa, Alan; Kuznetsov, Andrey; Philipson, Louis H.; Scherer, Norbert F.

    2017-05-01

    Imaging specific regions of interest (ROIs) of nanomaterials or biological samples with different imaging modalities (e.g., light and electron microscopy) or at subsequent time points (e.g., before and after off-microscope procedures) requires relocating the ROIs. Unfortunately, relocation is typically difficult and very time consuming to achieve. Previously developed techniques involve the fabrication of arrays of features, the procedures for which are complex, and the added features can interfere with imaging the ROIs. We report the Fast and Accurate Relocation of Microscopic Experimental Regions (FARMER) method, which only requires determining the coordinates of 3 (or more) conspicuous reference points (REFs) and employs an algorithm based on geometric operators to relocate ROIs in subsequent imaging sessions. The 3 REFs can be quickly added to various regions of a sample using simple tools (e.g., permanent markers or conductive pens) and do not interfere with the ROIs. The coordinates of the REFs and the ROIs are obtained in the first imaging session (on a particular microscope platform) using an accurate and precise encoded motorized stage. In subsequent imaging sessions, the FARMER algorithm finds the new coordinates of the ROIs (on the same or different platforms), using the coordinates of the manually located REFs and the previously recorded coordinates. FARMER is convenient, fast (3-15 min/session, at least 10-fold faster than manual searches), accurate (4.4 μm average error on a microscope with a 100x objective), and precise (almost all errors are diverse set of samples and imaging methods: live mammalian cells at different time points; fixed bacterial cells on two microscopes with different imaging modalities; and nanostructures on optical and electron microscopes. FARMER can be readily adapted to any imaging system with an encoded motorized stage and can facilitate multi-session and multi-platform imaging experiments in biology, materials science

  6. Fuel relocation as deduced from the gas flow resistance and thermal behavior of Halden Assembly IFA-430. [BWR; PWR

    Energy Technology Data Exchange (ETDEWEB)

    Dagbjartsson, S. J.; Appelhans, T. D.; Quapp, W. J.

    1979-01-01

    The relationship of axial gas flow and fuel temperature measurements to fuel cracking and relocation occurring during the first month of irradiation of light water reactor fuel rods is discussed. Two types of fuel rod axial gas flow tests were used to determine the effective hydraulic diameter and its change during the ramping operations. Fuel centerline and off-center measurements are compared with the results of the gas flow analysis and pretest FRAP calculations.

  7. Dual-earner couples’ willingness to relocate abroad: the reciprocal influence of both partners’ career role salience and partner role salience.

    NARCIS (Netherlands)

    Velde, M.E.G. van der; Jansen, P.G.W.; Bal, P.M.; Erp, K.J.P.M. van

    2016-01-01

    Successful international assignments are important for international organizations. Research has shown that employee willingness to relocate internationally strongly depends on spouse’s willingness to follow. However, the mechanisms driving these effects are not thoroughly investigated. This study g

  8. Dual-earner couples’ willingness to relocate abroad : the reciprocal influence of both partners’ career role salience and partner role salience

    NARCIS (Netherlands)

    van der Velde, Mandy E.G.; Jansen, Paul G.W.; Bal, P. Matthijs; van Erp, Kim

    2017-01-01

    Successful international assignments are important for international organizations. Research has shown that employee willingness to relocate internationally strongly depends on spouse’s willingness to follow. However, the mechanisms driving these effects are not thoroughly investigated. This study

  9. Dual-earner couples’ willingness to relocate abroad: the reciprocal influence of both partners’ career role salience and partner role salience.

    NARCIS (Netherlands)

    Velde, M.E.G. van der; Jansen, P.G.W.; Bal, P.M.; Erp, K.J.P.M. van

    2017-01-01

    Successful international assignments are important for international organizations. Research has shown that employee willingness to relocate internationally strongly depends on spouse’s willingness to follow. However, the mechanisms driving these effects are not thoroughly investigated. This study

  10. Malpositioned Osseointegrated Implants Relocated with Segmental Osteotomies : A Retrospective Analysis of a Multicenter Case Series with a 1-to 15-Year Follow-Up

    NARCIS (Netherlands)

    Stacchi, Claudio; Chen, Stephen T.; Raghoebar, Gerry M.; Rosen, Daren; Poggio, Carlo E.; Ronda, Marco; Bacchini, Marco; Di Lenarda, Roberto

    2013-01-01

    Purpose: This multicenter case series evaluates retrospectively the clinical outcomes of malpositioned implants surgically relocated in a more convenient position by segmental osteotomies. Materials and Methods: Authors who published, on indexed journals or books, works about malpositioned implant

  11. Mark-recapture and mark-resight methods for estimating abundance with remote cameras: a carnivore case study

    Science.gov (United States)

    Alanso, Robert S.; McClintock, Brett T.; Lyren, Lisa M.; Boydston, Erin E.; Crooks, Kevin R.

    2015-01-01

    Abundance estimation of carnivore populations is difficult and has prompted the use of non-invasive detection methods, such as remotely-triggered cameras, to collect data. To analyze photo data, studies focusing on carnivores with unique pelage patterns have utilized a mark-recapture framework and studies of carnivores without unique pelage patterns have used a mark-resight framework. We compared mark-resight and mark-recapture estimation methods to estimate bobcat (Lynx rufus) population sizes, which motivated the development of a new "hybrid" mark-resight model as an alternative to traditional methods. We deployed a sampling grid of 30 cameras throughout the urban southern California study area. Additionally, we physically captured and marked a subset of the bobcat population with GPS telemetry collars. Since we could identify individual bobcats with photos of unique pelage patterns and a subset of the population was physically marked, we were able to use traditional mark-recapture and mark-resight methods, as well as the new “hybrid” mark-resight model we developed to estimate bobcat abundance. We recorded 109 bobcat photos during 4,669 camera nights and physically marked 27 bobcats with GPS telemetry collars. Abundance estimates produced by the traditional mark-recapture, traditional mark-resight, and “hybrid” mark-resight methods were similar, however precision differed depending on the models used. Traditional mark-recapture and mark-resight estimates were relatively imprecise with percent confidence interval lengths exceeding 100% of point estimates. Hybrid mark-resight models produced better precision with percent confidence intervals not exceeding 57%. The increased precision of the hybrid mark-resight method stems from utilizing the complete encounter histories of physically marked individuals (including those never detected by a camera trap) and the encounter histories of naturally marked individuals detected at camera traps. This new estimator

  12. Mark-recapture and mark-resight methods for estimating abundance with remote cameras: a carnivore case study.

    Directory of Open Access Journals (Sweden)

    Robert S Alonso

    Full Text Available Abundance estimation of carnivore populations is difficult and has prompted the use of non-invasive detection methods, such as remotely-triggered cameras, to collect data. To analyze photo data, studies focusing on carnivores with unique pelage patterns have utilized a mark-recapture framework and studies of carnivores without unique pelage patterns have used a mark-resight framework. We compared mark-resight and mark-recapture estimation methods to estimate bobcat (Lynx rufus population sizes, which motivated the development of a new "hybrid" mark-resight model as an alternative to traditional methods. We deployed a sampling grid of 30 cameras throughout the urban southern California study area. Additionally, we physically captured and marked a subset of the bobcat population with GPS telemetry collars. Since we could identify individual bobcats with photos of unique pelage patterns and a subset of the population was physically marked, we were able to use traditional mark-recapture and mark-resight methods, as well as the new "hybrid" mark-resight model we developed to estimate bobcat abundance. We recorded 109 bobcat photos during 4,669 camera nights and physically marked 27 bobcats with GPS telemetry collars. Abundance estimates produced by the traditional mark-recapture, traditional mark-resight, and "hybrid" mark-resight methods were similar, however precision differed depending on the models used. Traditional mark-recapture and mark-resight estimates were relatively imprecise with percent confidence interval lengths exceeding 100% of point estimates. Hybrid mark-resight models produced better precision with percent confidence intervals not exceeding 57%. The increased precision of the hybrid mark-resight method stems from utilizing the complete encounter histories of physically marked individuals (including those never detected by a camera trap and the encounter histories of naturally marked individuals detected at camera traps. This new

  13. 病案库房搬迁的对策%Countermeasures of Relocation of Medical Record Storeroom

    Institute of Scientific and Technical Information of China (English)

    陈斌; 吴建成; 朱健倩

    2012-01-01

    病案库房搬迁存在着工期长短、病案安全、使用、短时存储空间不足等种种问题,这些是制约病案顺利、安全、有序完成搬迁的主要因素.分组分批、交错开工;制定制度、责任到人;科学计算、分色标签等是病案库房达到高效、低耗、安全搬迁的科学策略方案.%The relocation of 1he medical record storeroom has problem s such as duration of 1he work , medical record security and insufficient storage space. T hese are 1he m ain factors w hich constraint 1he relocation of m edical records sm oolhly , safely , orderly . T he scientific strategic plan includes grouped in batehes, staggered start, system devebp , people responsibility , scientific com putting , cobr separation and label and so on which can relocate m edical records storeroom efficiently , bw consum ption and security .

  14. Japan unified hIgh-resolution relocated catalog for earthquakes (JUICE): Crustal seismicity beneath the Japanese Islands

    Science.gov (United States)

    Yano, Tomoko E.; Takeda, Tetsuya; Matsubara, Makoto; Shiomi, Katsuhiko

    2017-04-01

    We have generated a high-resolution catalog called the ;Japan Unified hIgh-resolution relocated Catalog for Earthquakes; (JUICE), which can be used to evaluate the geometry and seismogenic depth of active faults in Japan. We relocated > 1.1 million hypocenters from the NIED Hi-net catalog for events which occurred between January 2001 and December 2012, to a depth of 40 km. We apply a relative hypocenter determination method to the data in each grid square, in which entire Japan is divided into 1257 grid squares to parallelize the relocation procedure. We used a double-difference method, incorporating cross-correlating differential times as well as catalog differential times. This allows us to resolve, in detail, a seismicity distribution for the entire Japanese Islands. We estimated location uncertainty by a statistical resampling method, using Jackknife samples, and show that the uncertainty can be within 0.37 km in the horizontal and 0.85 km in the vertical direction with a 90% confidence interval for areas with good station coverage. Our seismogenic depth estimate agrees with the lower limit of the hypocenter distribution for a recent earthquake on the Kamishiro fault (2014, Mj 6.7), which suggests that the new catalog should be useful for estimating the size of future earthquakes for inland active faults.

  15. Effectiveness of coral relocation as a mitigation strategy in Kāne'ohe Bay, Hawai'i.

    Science.gov (United States)

    Rodgers, Ku'ulei S; Lorance, Koi; Richards Donà, Angela; Stender, Yuko; Lager, Claire; Jokiel, Paul L

    2017-01-01

    Coral reef restoration and management techniques are in ever-increasing demand due to the global decline of coral reefs in the last several decades. Coral relocation has been established as an appropriate restoration technique in select cases, particularly where corals are scheduled for destruction. However, continued long-term monitoring of recovery of transplanted corals is seldom sustained. Removal of coral from a navigation channel and relocation to a similar nearby dredged site occurred in 2005. Coral recovery at the donor site and changes in fish populations at the receiving site were tracked periodically over the following decade. Coral regrowth at the donor site was rapid until a recent bleaching event reduced coral cover by more than half. The transplant of mature colonies increased spatial complexity at the receiving site, immediately increasing fish biomass, abundance, and species that was maintained throughout subsequent surveys. Our research indicates that unlike the majority of historical accounts of coral relocation in the Pacific, corals transplanted into wave-protected areas with similar conditions as the original site can have high survival rates. Data on long-term monitoring of coral transplants in diverse environments is central in developing management and mitigation strategies.

  16. Genetics behind barbed wire: Masuo Kodani, émigré geneticists, and wartime genetics research at Manzanar relocation center.

    Science.gov (United States)

    Smocovitis, Vassiliki Betty

    2011-02-01

    This article explores the sociopolitical backdrop of genetics research during the politically turbulent decades of the mid-20th century that saw the persecution, displacement, and relocation of unpopular minorities in both the United States and Europe. It explores how geneticists in the United States accommodated these disruptions through formal and informal émigré networks and how the subsequent war affected their research programs and their lives. It does so by focusing on the career and life of geneticist Masuo Kodani, who, as a Japanese American, found himself conducting unexpected cytogenetics research in Manzanar, a "relocation center," or internment camp, located in the California desert, after the attack on Pearl Harbor. After the war, Kodani's subsequent career continued to be shaped by his experiences as a Japanese American and by the specific skills as a cytogeneticist that he demonstrated at a critical period in the history of 20th-century genetics. His many relocations in search of employment culminated in his work with the Atomic Bomb Casualty Commission on human chromosomes, for which he is best known.

  17. Effectiveness of coral relocation as a mitigation strategy in Kāne‘ohe Bay, Hawai‘i

    Directory of Open Access Journals (Sweden)

    Ku’ulei S. Rodgers

    2017-05-01

    Full Text Available Coral reef restoration and management techniques are in ever-increasing demand due to the global decline of coral reefs in the last several decades. Coral relocation has been established as an appropriate restoration technique in select cases, particularly where corals are scheduled for destruction. However, continued long-term monitoring of recovery of transplanted corals is seldom sustained. Removal of coral from a navigation channel and relocation to a similar nearby dredged site occurred in 2005. Coral recovery at the donor site and changes in fish populations at the receiving site were tracked periodically over the following decade. Coral regrowth at the donor site was rapid until a recent bleaching event reduced coral cover by more than half. The transplant of mature colonies increased spatial complexity at the receiving site, immediately increasing fish biomass, abundance, and species that was maintained throughout subsequent surveys. Our research indicates that unlike the majority of historical accounts of coral relocation in the Pacific, corals transplanted into wave-protected areas with similar conditions as the original site can have high survival rates. Data on long-term monitoring of coral transplants in diverse environments is central in developing management and mitigation strategies.

  18. The 2008 Wells, Nevada earthquake sequence: Source constraints using calibrated multiple event relocation and InSAR

    Science.gov (United States)

    Nealy, Jennifer; Benz, Harley M.; Hayes, Gavin; Berman, Eric; Barnhart, William

    2017-01-01

    The 2008 Wells, NV earthquake represents the largest domestic event in the conterminous U.S. outside of California since the October 1983 Borah Peak earthquake in southern Idaho. We present an improved catalog, magnitude complete to 1.6, of the foreshock-aftershock sequence, supplementing the current U.S. Geological Survey (USGS) Preliminary Determination of Epicenters (PDE) catalog with 1,928 well-located events. In order to create this catalog, both subspace and kurtosis detectors are used to obtain an initial set of earthquakes and associated locations. The latter are then calibrated through the implementation of the hypocentroidal decomposition method and relocated using the BayesLoc relocation technique. We additionally perform a finite fault slip analysis of the mainshock using InSAR observations. By combining the relocated sequence with the finite fault analysis, we show that the aftershocks occur primarily updip and along the southwestern edge of the zone of maximum slip. The aftershock locations illuminate areas of post-mainshock strain increase; aftershock depths, ranging from 5 to 16 km, are consistent with InSAR imaging, which shows that the Wells earthquake was a buried source with no observable near-surface offset.

  19. Effects of Relocation and Individual and Environmental Factors on the Long-Term Stress Levels in Captive Chimpanzees (Pan troglodytes: Monitoring Hair Cortisol and Behaviors.

    Directory of Open Access Journals (Sweden)

    Yumi Yamanashi

    Full Text Available Understanding the factors associated with the long-term stress levels of captive animals is important from the view of animal welfare. In this study, we investigated the effects of relocation in addition to individual and environmental factors related to social management on long-term stress level in group-living captive chimpanzees by examining behaviors and hair cortisol (HC. Specifically, we conducted two studies. The first compared changes in HC levels before and after the relocation of 8 chimpanzees (Study 1 and the second examined the relationship between individual and environmental factors and individual HC levels in 58 chimpanzees living in Kumamoto Sanctuary (KS, Kyoto University (Study 2. We hypothesized that relocation, social situation, sex, and early rearing conditions, would affect the HC levels of captive chimpanzees. We cut arm hair from chimpanzees and extracted and assayed cortisol with an enzyme immunoassay. Aggressive behaviors were recorded ad libitum by keepers using a daily behavior monitoring sheet developed for this study. The results of Study 1 indicate that HC levels increased during the first year after relocation to the new environment and then decreased during the second year. We observed individual differences in reactions to relocation and hypothesized that social factors may mediate these changes. In Study 2, we found that the standardized rate of receiving aggression, rearing history, sex, and group formation had a significant influence on mean HC levels. Relocation status was not a significant factor, but mean HC level was positively correlated with the rate of receiving aggression. Mean HC levels were higher in males than in females, and the association between aggressive interactions and HC levels differed by sex. These results suggest that, although relocation can affect long-term stress level, individuals' experiences of aggression and sex may be more important contributors to long-term stress than

  20. Frequent relocations between asylum-seeker centres are associated with mental distress in asylum-seeking children: a longitudinal medical record study.

    Science.gov (United States)

    Goosen, Simone; Stronks, Karien; Kunst, Anton E

    2014-02-01

    There are concerns about negative effects of relocations between asylum-seeker centres on the mental health of asylum-seeking children. However, empirical evidence comes from cross-sectional studies only. In this longitudinal medical record study, we aimed to assess: (i) whether relocations during the asylum process are associated with the incidence of newly recorded mental distress in asylum-seeking children; and (ii) whether this association is stronger among vulnerable children. Data were extracted from the electronic medical records database of the Community Health Services for Asylum Seekers in The Netherlands (study period: 1 January 2000-31 December 2008). Included were 8047 children aged 4 to 17 years. Case attribution was done using International Classification of Primary Care codes for mental, behavioural or psychosocial problems. The association between annual relocation rate and incidence of mental distress was measured using relative risks (RR) estimated with multivariate Cox regression models. A high annual relocation rate (>1 relocation/year) was associated with increased incidence of mental distress [RR = 2.70; 95% confidence interval (CI) 2.30-3.17]. The relative risk associated with a high annual relocation rate was larger in children who had experienced violence (RR = 3.87; 95% CI 2.79-5.37) and in children whose mothers had been diagnosed with post-traumatic stress disorder or depression (RR = 3.40; 95% CI 2.50-4.63). The risk of mental distress was greater in asylum-seeking children who had undergone a high annual relocation rate. This risk increase was stronger in vulnerable children. These findings contribute to the appeal for policies that minimize the relocation of asylum seekers.