WorldWideScience

Sample records for individual grb sensitivity

  1. Stirring the Embers: High-Sensitivity VLBI Observations of GRB 030329

    Energy Technology Data Exchange (ETDEWEB)

    Pihlstrom, Y.M.; Taylor, G.B.; /New Mexico U.; Granot, J.; /KIPAC, Menlo Park; Doeleman, S.; /MIT, Haystack Observ.

    2007-09-24

    We present high-sensitivity Very Long Baseline Interferometry (VLBI) observations 806 days after the {gamma}-ray burst of 2003 March 29 (GRB 030329). The angular diameter of the radio afterglow is measured to be 0:347 {+-} 0:09 mas, corresponding to 0:99 {+-} 0:26 pc at the redshift of GRB 030329 (z = 0:1685). The evolution of the image size favors a uniform external density over an R{sup -2} windlike density profile (at distances of R {approx}> 10{sup 18} cm from the source), although the latter cannot be ruled out yet. The current apparent expansion velocity of the image size is only mildly relativistic, suggesting a nonrelativistic transition time of tNR {approx} 1 yr. A rebrightening, or at least a significant flattening in the flux decay, is expected within the next several years as the counterjet becomes visible (this has not yet been observed). An upper limit of <1.9c is set on the proper motion of the flux centroid.

  2. The GRB Simulator: A System for Testing GOES Rebroadcast (GRB)

    Science.gov (United States)

    Gibbons, K.; Race, R.; Miller, C.; Barnes, K.; Dittberner, G.

    2012-12-01

    GOES Rebroadcast (GRB) signals in the GOES-R era will replace the current legacy GOES Variable (GVAR) signal and will have substantially different characteristics, including a change in data rate from a single 2.1 Mbps stream to two digital streams of 15.5 Mbps each. The GRB Simulator is a portable system that outputs a high-fidelity stream of Consultative Committee for Space Data Systems (CCSDS) formatted GRB packet data equivalent to live GRB data. The data is used for on-site testing of user ingest and data handling systems known as field terminal sites. The GRB Simulator is a fully self-contained system which includes all hardware units needed for operation. The operator manages configurations to edit preferences, define individual test scenarios, and manage event logs and reports. Simulations are controlled by test scenarios, which are scripts that specify the test data and provide a series of actions for the GRB Simulator to perform when generating GRB output. Scenarios allow for the insertion of errors or modification of GRB packet headers for testing purposes. The GRB Simulator provides a built-in editor for managing scenarios. Data output by the simulator is derived from either proxy data files containing Level 1b (L1b) or GLM L2+ data, test pattern images, or non-image test pattern generation commands specified from within a scenario. The GRB Simulator outputs packets containing both instrument and GRB Information data. Instrument packets contain data simulated from any instrument: the Advanced Baseline Imager (ABI), Solar Ultraviolet Imager (SUVI), Space Environment In-Situ Suite (SEISS), Extreme Ultraviolet Sensor (EUVS) and X-ray Irradiance Sensor (XRS) called EXIS, Geostationary Lightning Mapper (GLM), or the Magnetometer. The GRB Information packets contain information such as satellite schedules. The GRB Simulator will provide GRB data as either baseband (digital) or Intermediate Frequency (IF) output to the test system. GRB packet data will be sent

  3. GRB 090313

    DEFF Research Database (Denmark)

    de Ugarte Postigo...[}, A.; Goldoni, P.; Thöne, Christina;

    2010-01-01

    % illuminated Moon was just 30 degrees away from the field. In spite of the adverse conditions, we obtained a spectrum that, for the first time in GRB research, simultaneously covers the range from 5700 to 23¿000 Å. Results. The spectrum shows multiple absorption features at a redshift of 3.3736, which we......Context. X-shooter is the first second-generation instrument to become operative at the ESO Very Large Telescope (VLT). It is a broad-band medium-resolution spectrograph designed with gamma-ray burst (GRB) afterglow spectroscopy as one of its main science drivers. Aims. During the first...

  4. GRB 050319

    DEFF Research Database (Denmark)

    Fynbo, J.P.U; Hjorth, J.; Jakobsson, P.

    2005-01-01

    "Using ALFOSC on the Nordic Optical Telescope (NOT) we have obtained spectra of the afterglow of GRB 050319 (GCN 3116, 3117) on 2005, March 20 UT. We find several absorption features, including strong Lyman-alpha, OI+SiII, SiIV and CIV, corresponding to a redshift of z=3.24."......"Using ALFOSC on the Nordic Optical Telescope (NOT) we have obtained spectra of the afterglow of GRB 050319 (GCN 3116, 3117) on 2005, March 20 UT. We find several absorption features, including strong Lyman-alpha, OI+SiII, SiIV and CIV, corresponding to a redshift of z=3.24."...

  5. Type 2 Diabetes Risk Alleles Near BCAR1 and in ANK1 Associate With Decreased ß-Cell Function Whereas Risk Alleles Near ANKRD55 and GRB14 Associate With Decreased Insulin Sensitivity in the Danish Inter99 Cohort

    DEFF Research Database (Denmark)

    Harder, Marie N; Ribel-Madsen, Rasmus; Justesen, Johanne M

    2013-01-01

    was to characterize prediabetic quantitative traits underlying these SNP associations and to calculate the amount of interindividual variation in glycemic traits explained by these and previous T2D susceptibility variants.Design and Participants:A total of 5739 Danish individuals naive to glucose-lowering medication......Context:Recently, 10 novel type 2 diabetes (T2D) susceptibility single nucleotide polymorphisms (SNPs) in ZMIZ1, ANK1, KLHDC5, TLE1, ANKRD55, CILP2, MC4R, BCAR1, HMG20A, and GRB14 loci were discovered in MetaboChip-genotyped populations of European ancestry.Objective:The aim of the present study...... were included in quantitative trait studies, and case-control analyses were performed in 1892 patients with T2D and 6603 normoglycemic control subjects. Participants without known T2D underwent an oral glucose tolerance test, and measures of insulin release and sensitivity were estimated from...

  6. GRB Simulations in GLAST

    Energy Technology Data Exchange (ETDEWEB)

    Omodei, Nicola; /INFN, Pisa; Battelino, Milan; /Stockholm Observ.; Komin, Nukri; /Montpellier U.; Longo, Francesco; /INFN, Trieste /Trieste U.; McEnery, Julie; /NASA, Goddard; Ryde, Felix; /Denver U.

    2007-10-22

    The Gamma-ray Large Area Space Telescope (GLAST), scheduled to be launched in fall of 2007, is the next generation satellite for high-energy gamma-ray astronomy. The Large Area Telescope (LAT) is a pair conversion telescope built with a high precision silicon tracker, a segmented CsI electromagnetic calorimeter and a plastic anticoincidence shield. The LAT will survey the sky in the energy range between 20 MeV to more than 300 GeV, shedding light on many issues left open by its highly successful predecessor EGRET. LAT will observe Gamma-Ray Bursts (GRB) in an energy range never explored before; to tie these frontier observations to the better-known properties at lower energies, a second instrument, the GLAST Burst Monitor (GBM) will provide important spectra and timing in the 10 keV to 30 MeV range. We briefly present the instruments onboard the GLAST satellite, their synergy in the GRB observations and the work done so far by the collaboration in simulation, analysis, and GRB sensitivity estimation.

  7. GRB 051008

    DEFF Research Database (Denmark)

    Volnova, A. A.; Pozanenko, A. S.; Gorosabel, J.

    2014-01-01

    in gamma- and X-rays and neither a prompt optical nor a radio afterglow was detected down to deep limits. We identified the host galaxy of the burst, which is a typical Lyman-break galaxy (LBG) with R-magnitude of 24.06 ± 0.10 mag. A redshift of the galaxy of z=2.77+0.15−0.20 is measured photometrically...... due to the presence of a clear, strong Lyman-break feature. The host galaxy is a small starburst galaxy with moderate intrinsic extinction (AV = 0.3) and has a star formation rate of ∼60 M⊙ yr−1 typical for LBGs. It is one of the few cases where a GRB host has been found to be a classical LBG. Using...

  8. Long and short GRB

    CERN Document Server

    Katz, J I

    1995-01-01

    We report evidence from the 3B Catalogue that short (T_90 10 s) GRB represent different populations and processes: Their spectral behavior is qualitatively different, with short bursts harder in the BATSE range, but chiefly long bursts detected at higher photon energies; \\langle V/V_max \\rangle = 0.385 \\pm 0.019 for short GRB but \\langle V/V_max \\rangle = 0.282 \\pm 0.014 for long GRB, differing by 0.103 \\pm 0.024. Long GRB may be the consequence of accretion-induced collapse, but this mechanism fails for short GRB, for which we suggest colliding neutron stars.

  9. [Individual sensitivity of Wistar rats to piracetam].

    Science.gov (United States)

    Nikol'skaia, K A; Kondrashevskaia, M V; Eremina, L V

    2007-11-01

    Effects of repeated piracetam (PIR) injections in a dose of 40 and 250 mg/kg/day on the learning in Water rats were studied. It has been found that character of the effects depends on typological features of the animals. Rats with strong predominance of excitation (choleric type) showed low sensitivity to PIR. Small dose of PIR provoked clear negative effect in rats with relative balance of the basic nervous processes: excitation and inhibition (sanguine and phlegmatic types). Despite of expressed activation of associative process, it complicated integrative activity. Small dose of PIR showed anxiolytic and psycho-stimulant actions only in initially unlearned rats characterized by high level of fear. Large dose of PIR had negative influence on the learning process in all animals, irrespective of typological features. Thus, the results of this study allow to suppose that the individual sensitivity of an animal to action of a pharmacological medication is caused by morpho-functional and neurochemical intraspecific heterogeneity.

  10. Individual radiation sensitivity: implications in medical practice

    Energy Technology Data Exchange (ETDEWEB)

    Gisone, P.; Dubner, D.; Perez, M.D.R.; Michelin, S.; Di Giogio, M. [Autoridad Regulatoria Nuclear, Buenos Aires (Argentina); Bourguignon, M. [Direction Generale de la Surete Nucleaire et de la Radioprotection, Paris (France)

    2006-07-01

    Important advances in radiotherapy and nuclear medicine towards better treatment modalities and safer applications have taken place in recent years. Progress in medical imaging, better tumour targeting and optimization of radiation delivery have allowed for dose escalation and improved patient outcome. However, the tolerance of normal tissues constitutes the limiting factor for dose escalation in therapeutical uses of ionizing radiation (IR). Patients vary considerably in their normal tissue response to IR even after similar treatments. As many as 5% of cancer patients develop severe effects to external radiation therapy in normal tissues within the treatment field: they may include acute effects such as erythema and desquamation of the exposed skin and mucosa that appear during or directly after radiotherapy, late effects developed months or years later, such as fibrosis and telangiectasia and cancer induction. Several patient and treatment related factors are known to influence the variability of side effects, however up to a 70% of the total variance of normal tissue radiation response remained unexplained. Thus, individual sensitivity to IR, i.e. hypersensitivity to carcinogenic risks (stochastic effects) and hypersensitivity to deterministic effects, is becoming an important issue in oncology and raises questions regarding the underlying mechanisms. The mechanisms of DNA repair, the signalling pathways involved in radiation sensitivity and non-targeted effects are key aspects, essential to understanding radiation effects at genetic level. Moreover, human genetic diseases that combine higher incidence of cancer and hypersensitivity to IR are associated with defects in cell response to DNA damage. Therefore, much interest has raised during the last years in the developing of predictive tests capable to detect in advance such hypersensitive conditions. The goal of this presentation is to review the possible mechanisms involved in genetic and epigenetic

  11. Prompt GRB optical follow-up experiments

    Energy Technology Data Exchange (ETDEWEB)

    Park, H-S; Williams, G; Ables, E; Band, D; Barthelmy, S; Bionta, R; Cline, T; Gehrels, N; Hartmann, D; Hurley, K; Kippen, M; Nemiroff, R; Pereira, W; Porrata, R

    2000-11-13

    Gamma Ray Bursts (GRBs) are brief, randomly located, releases of gamma-ray energy from unknown celestial sources that occur almost daily. The study of GRBs has undergone a revolution in the past three years due to an international effort of follow-up observations of coordinates provided by Beppo/SAX and IPN GRB. These follow-up observations have shown that GRBs are at cosmological distances and interact with surrounding material as described by the fireball model. However, prompt optical counterparts have only been seen in one case and are therefore very rare or much dimmer than the sensitivity of the current instruments. Unlike later time afterglows, prompt optical measurements would provide information on the GRB progenitor. LOTIS is the very first automated and dedicated telescope system that actively utilizes the GRB Coordinates Network (GCN) and it attempts to measure simultaneous optical light curve associated with GRBs. After 3 years of running, LOTIS has responded to 75 GRB triggers. The lack of any optical signal in any of the LOTIS images places numerical limits on the surrounding matter density, and other physical parameters in the environment of the GRB progenitor. This paper presents LOTIS results and describes other prompt GRB follow-up experiments including the Super-LOTIS at Kitt Peak in Arizona.

  12. The HAWC GRB Programme

    Science.gov (United States)

    Lennarz, D.; Taboada, I.

    2016-10-01

    HAWC is a very-high-energy gamma-ray extensive air shower detector located in central Mexico at an altitude of 4,100 m above sea level. This contribution summarises recent results of the HAWC GRB programme.

  13. GRB as luminosity indicator

    CERN Document Server

    Basak, Rupal

    2014-01-01

    Gamma Ray Bursts (GRBs) are found at much higher redshifts (z>6) than Supernova Ia (z~1), and hence, they can be used to probe very primitive universe. However, radiation mechanism of GRB remains a puzzle, unlike Supernova Ia. Through comprehensive description, both empirical and physical, we shall discuss the most likely way to use the constituent pulses of a GRB to find the radiation mechanism as well as using the pulses as luminosity indicators.

  14. Measuring the pulse of GRB 090618: A Simultaneous Spectral and Timing Analysis of the Prompt Emission

    CERN Document Server

    RupalBasak,

    2011-01-01

    We develop a new method for simultaneous timing and spectral studies of Gamma Ray Burst (GRB) prompt emission and apply it to make a pulse-wise description of the prompt emission of GRB 090618, the brightest GRB detected in the Fermi era. We exploit the large area (and sensitivity) of Swift/BAT and the wide band width of Fermi/GBM to derive the parameters for a complete spectral and timing description of the individual pulses of this GRB, based on the various empirical relations suggested in the literature. We demonstrate that this empirical model correctly describes the other observed properties of the burst like the variation of the lag with energy and the pulse width with energy. The measurements also show an indication of an increase in pulse width as a function of energy at low energies for some of the pulses, which is naturally explained as an off-shoot of some particular combination of the model parameters. We argue that these model parameters, particularly the peak energy at the beginning of the pulse...

  15. Is GRB 100418A a Cosmic Twin of GRB 060614?

    Indian Academy of Sciences (India)

    Lan-Wei Jia; Hou-Jun Lü; Shu-Jin Hou; En-Wei Liang

    2011-03-01

    GRB 100418A is a long burst at = 0.624 without detection of associated supernova (SN).We present a detailed analysis on this event and discuss possible origins of its multi-wavelength emission. The temporal features of this event is similar to GRB 060614, a well-known nearby long GRB without SN association (possibly a Type I GRB), indicating that the two events may be cosmic twins. However, both the circumburst medium density and the GRB classification based on the gamma-ray energy and spectrum suggest that GRB 100418A would be a Type II GRB. These results make a great puzzle on the progenitors of this kind of events, if they belong to the same population.

  16. Vantage sensitivity: individual differences in response to positive experiences.

    Science.gov (United States)

    Pluess, Michael; Belsky, Jay

    2013-07-01

    The notion that some people are more vulnerable to adversity as a function of inherent risk characteristics is widely embraced in most fields of psychology. This is reflected in the popularity of the diathesis-stress framework, which has received a vast amount of empirical support over the years. Much less effort has been directed toward the investigation of endogenous factors associated with variability in response to positive influences. One reason for the failure to investigate individual differences in response to positive experiences as a function of endogenous factors may be the absence of adequate theoretical frameworks. According to the differential-susceptibility hypothesis, individuals generally vary in their developmental plasticity regardless of whether they are exposed to negative or positive influences--a notion derived from evolutionary reasoning. On the basis of this now well-supported proposition, we advance herein the new concept of vantage sensitivity, reflecting variation in response to exclusively positive experiences as a function of individual endogenous characteristics. After distinguishing vantage sensitivity from theoretically related concepts of differential-susceptibility and resilience, we review some recent empirical evidence for vantage sensitivity featuring behavioral, physiological, and genetic factors as moderators of a wide range of positive experiences ranging from family environment and psychotherapy to educational intervention. Thereafter, we discuss genetic and environmental factors contributing to individual differences in vantage sensitivity, potential mechanisms underlying vantage sensitivity, and practical implications.

  17. Insulin sensitivity in clinically healthy individuals with microalbuminuria

    DEFF Research Database (Denmark)

    Jensen, J S; Borch-Johnsen, K; Jensen, G;

    1996-01-01

    In epidemiologic studies microalbuminuria is associated with increased atherosclerotic risk profile, morbidity, and mortality. In order to examine whether such association could be explained by impaired insulin sensitivity, 23 clinically healthy subjects with microalbuminuria (urinary albumin...... glucose, tobacco and alcohol consumption, physical activity, and age and sex, fasting serum insulin concentration was the only variable independently associated with insulin sensitivity (r = -0.55; P = 0.0001). It is concluded that microalbuminuria is not associated with impaired insulin sensitivity...... in clinically healthy individuals. The effect of microalbuminuria as predictor of atherosclerotic vascular disease may be mediated through other factors....

  18. Implications for the Origin of GRB 070201 from LIGO Observations

    Science.gov (United States)

    Abbott, B.; Abbott, R.; Adhikari, R.; Agresti, J.; Ajith, P.; Allen, B.; Amin, R.; Anderson, S. B.; Anderson, W. G.; Arain, M.; Araya, M.; Armandula, H.; Ashley, M.; Aston, S.; Aufmuth, P.; Aulbert, C.; Babak, S.; Ballmer, S.; Bantilan, H.; Barish, B. C.; Barker, C.; Barker, D.; Barr, B.; Barriga, P.; Barton, M. A.; Bayer, K.; Betzwieser, J.; Beyersdorf, P. T.; Bhawal, B.; Bilenko, I. A.; Billingsley, G.; Biswas, R.; Black, E.; Blackburn, K.; Blackburn, L.; Blair, D.; Bland, B.; Bogenstahl, J.; Bogue, L.; Bork, R.; Boschi, V.; Bose, S.; Brady, P. R.; Braginsky, V. B.; Brau, J. E.; Brinkmann, M.; Brooks, A.; Brown, D. A.; Bullington, A.; Bunkowski, A.; Buonanno, A.; Burmeister, O.; Busby, D.; Byer, R. L.; Cadonati, L.; Cagnoli, G.; Camp, J. B.; Cannizzo, J.; Cannon, K.; Cantley, C. A.; Cao, J.; Cardenas, L.; Castaldi, G.; Cepeda, C.; Chalkley, E.; Charlton, P.; Chatterji, S.; Chelkowski, S.; Chen, Y.; Chiadini, F.; Christensen, N.; Clark, J.; Cochrane, P.; Cokelaer, T.; Coldwell, R.; Conte, R.; Cook, D.; Corbitt, T.; Coyne, D.; Creighton, J. D. E.; Croce, R. P.; Crooks, D. R. M.; Cruise, A. M.; Cumming, A.; Dalrymple, J.; D'Ambrosio, E.; Danzmann, K.; Davies, G.; DeBra, D.; Degallaix, J.; Degree, M.; Demma, T.; Dergachev, V.; Desai, S.; DeSalvo, R.; Dhurandhar, S.; Díaz, M.; Dickson, J.; Di Credico, A.; Diederichs, G.; Dietz, A.; Doomes, E. E.; Drever, R. W. P.; Dumas, J.-C.; Dupuis, R. J.; Dwyer, J. G.; Ehrens, P.; Espinoza, E.; Etzel, T.; Evans, M.; Evans, T.; Fairhurst, S.; Fan, Y.; Fazi, D.; Fejer, M. M.; Finn, L. S.; Fiumara, V.; Fotopoulos, N.; Franzen, A.; Franzen, K. Y.; Freise, A.; Frey, R.; Fricke, T.; Fritschel, P.; Frolov, V. V.; Fyffe, M.; Galdi, V.; Garofoli, J.; Gholami, I.; Giaime, J. A.; Giampanis, S.; Giardina, K. D.; Goda, K.; Goetz, E.; Goggin, L. M.; González, G.; Gossler, S.; Grant, A.; Gras, S.; Gray, C.; Gray, M.; Greenhalgh, J.; Gretarsson, A. M.; Grosso, R.; Grote, H.; Grunewald, S.; Guenther, M.; Gustafson, R.; Hage, B.; Hammer, D.; Hanna, C.; Hanson, J.; Harms, J.; Harry, G.; Harstad, E.; Hayler, T.; Heefner, J.; Heng, I. S.; Heptonstall, A.; Heurs, M.; Hewitson, M.; Hild, S.; Hirose, E.; Hoak, D.; Hosken, D.; Hough, J.; Hoyland, D.; Huttner, S. H.; Ingram, D.; Innerhofer, E.; Ito, M.; Itoh, Y.; Ivanov, A.; Johnson, B.; Johnson, W. W.; Jones, D. I.; Jones, G.; Jones, R.; Ju, L.; Kalmus, P.; Kalogera, V.; Kasprzyk, D.; Katsavounidis, E.; Kawabe, K.; Kawamura, S.; Kawazoe, F.; Kells, W.; Keppel, D. G.; Khalili, F. Ya.; Kim, C.; King, P.; Kissel, J. S.; Klimenko, S.; Kokeyama, K.; Kondrashov, V.; Kopparapu, R. K.; Kozak, D.; Krishnan, B.; Kwee, P.; Lam, P. K.; Landry, M.; Lantz, B.; Lazzarini, A.; Lei, M.; Leiner, J.; Leonhardt, V.; Leonor, I.; Libbrecht, K.; Lindquist, P.; Lockerbie, N. A.; Longo, M.; Lormand, M.; Lubinski, M.; Lück, H.; Machenschalk, B.; MacInnis, M.; Mageswaran, M.; Mailand, K.; Malec, M.; Mandic, V.; Marano, S.; Márka, S.; Markowitz, J.; Maros, E.; Martin, I.; Marx, J. N.; Mason, K.; Matone, L.; Matta, V.; Mavalvala, N.; McCarthy, R.; McClelland, D. E.; McGuire, S. C.; McHugh, M.; McKenzie, K.; McWilliams, S.; Meier, T.; Melissinos, A.; Mendell, G.; Mercer, R. A.; Meshkov, S.; Messenger, C. J.; Meyers, D.; Mikhailov, E.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Miyakawa, O.; Mohanty, S.; Moreno, G.; Mossavi, K.; MowLowry, C.; Moylan, A.; Mudge, D.; Mueller, G.; Mukherjee, S.; Müller-Ebhardt, H.; Munch, J.; Murray, P.; Myers, E.; Myers, J.; Nash, T.; Newton, G.; Nishizawa, A.; Numata, K.; O'Reilly, B.; O'Shaughnessy, R.; Ottaway, D. J.; Overmier, H.; Owen, B. J.; Pan, Y.; Papa, M. A.; Parameshwaraiah, V.; Patel, P.; Pedraza, M.; Penn, S.; Pierro, V.; Pinto, I. M.; Pitkin, M.; Pletsch, H.; Plissi, M. V.; Postiglione, F.; Prix, R.; Quetschke, V.; Raab, F.; Rabeling, D.; Radkins, H.; Rahkola, R.; Rainer, N.; Rakhmanov, M.; Ramsunder, M.; Ray-Majumder, S.; Re, V.; Rehbein, H.; Reid, S.; Reitze, D. H.; Ribichini, L.; Riesen, R.; Riles, K.; Rivera, B.; Robertson, N. A.; Robinson, C.; Robinson, E. L.; Roddy, S.; Rodriguez, A.; Rogan, A. M.; Rollins, J.; Romano, J. D.; Romie, J.; Route, R.; Rowan, S.; Rüdiger, A.; Ruet, L.; Russell, P.; Ryan, K.; Sakata, S.; Samidi, M.; Sancho de la Jordana, L.; Sandberg, V.; Sannibale, V.; Saraf, S.; Sarin, P.; Sathyaprakash, B. S.; Sato, S.; Saulson, P. R.; Savage, R.; Savov, P.; Schediwy, S.; Schilling, R.; Schnabel, R.; Schofield, R.; Schutz, B. F.; Schwinberg, P.; Scott, S. M.; Searle, A. C.; Sears, B.; Seifert, F.; Sellers, D.; Sengupta, A. S.; Shawhan, P.; Shoemaker, D. H.; Sibley, A.; Siemens, X.; Sigg, D.; Sinha, S.; Sintes, A. M.; Slagmolen, B. J. J.; Slutsky, J.; Smith, J. R.; Smith, M. R.; Somiya, K.; Strain, K. A.; Strom, D. M.; Stuver, A.; Summerscales, T. Z.; Sun, K.-X.; Sung, M.; Sutton, P. J.; Takahashi, H.

    2008-07-01

    We analyzed the available LIGO data coincident with GRB 070201, a short-duration, hard-spectrum γ-ray burst (GRB) whose electromagnetically determined sky position is coincident with the spiral arms of the Andromeda galaxy (M31). Possible progenitors of such short, hard GRBs include mergers of neutron stars or a neutron star and a black hole, or soft γ-ray repeater (SGR) flares. These events can be accompanied by gravitational-wave emission. No plausible gravitational-wave candidates were found within a 180 s long window around the time of GRB 070201. This result implies that a compact binary progenitor of GRB 070201, with masses in the range 1 M⊙ 99% confidence. If the GRB 070201 progenitor was not in M31, then we can exclude a binary neutron star merger progenitor with distance D < 3.5 Mpc, assuming random inclination, at 90% confidence. The result also implies that an unmodeled gravitational-wave burst from GRB 070201 most probably emitted less than 4.4 × 10-4 M⊙c2 (7.9 × 1050 ergs) in any 100 ms long period within the signal region if the source was in M31 and radiated isotropically at the same frequency as LIGO's peak sensitivity (f ≈ 150 Hz). This upper limit does not exclude current models of SGRs at the M31 distance.

  19. [Procedure for determination of individual sensitivity to antitumor drugs].

    Science.gov (United States)

    Abduvaliev, A A; Gil'dieva, M S; Tatarskiĭ, V P

    2006-05-01

    The present paper proposes to employ the cultured tumor cells of the breast and chick fibroblasts after long-term cultivation (for above 24 days) to determine their individual drug sensitivity and, as a criterion of cell damage, to use the percent of destruction of the cell layer formed in the wells 24 hours after drug insertion. It also presents the comparative results of tests of 2 cellular models that have been used to determine the in vitro sensitivity of the cells of breast cancer and chick fibroblasts to melfalan and its complex compound with copper acetylacetonate - MOK*M. At the same time, the cytotoxic activity of MOK*M and melfalan against tumor cells has been not shown to differ greatly (16.02+/-1.85 and 15.71+/-0.65% cell layer destruction, respectively), but the same activity of MOK*M against the model of intact cells (chick fibroblasts) was much less (15.23+/-1.97%) than that of melfalan (95.39+/-1.11%). The test system proposed by the authors is of certain informative value and it may be used for the determination of the individual sensitivity of tumor cells to antitumor drugs.

  20. Development of wide-band GRB detectors and the GRB monitor for the CALET Experiment

    Science.gov (United States)

    Yoshida, Atsumasa; Yamaoka, Kazutaka; Nakagawa, Yujin; Nakahira, Satoshi; Sugita, Satoshi; Tomida, Hiroshi; Torii, Shoji

    Many previous observations revealed radiations from GRBs to be widely emitted in electromagnetic energy band form less than a keV to over a GeV range, and peak-energies of νFν spectra to be distributed rather more widely than expected before. Those includes soft events explored by Ginga, BeppoSAX and HETE-2, and delayed GeV emissions and additional hard continuum detected by EGRET. It is very important to have a GRB monitor in space to be sensitive to photons in continuously wide energy range. We are developing wide-band GRB detectors utilizing several kinds of scintillator and X-ray CCD for future space missions. One of these detectors is that proposed as a GRB Monitor for the CALorimetric Electron Telescope (CALET) mission that was selected for Phase A/B studies as a next experiment for JEM-EF of ISS. The GRB Monitor (GBM) is a part of this experiment to extend scientific products achieved by CALET which can detect gamma-rays in a range from about 20MeV to TeV by itself and is potentially sensitive to hard radiations from GRBs. GBM is designed as multiple scintillation counters made of BGO and LaBr3 (Ce) to detect GRBs in a few keV to about 20MeV range alone, and to cover the energy band continuously up-to TeV region together with the CALET's main instruments, Imaging Calorimeter (IMC) and Total Absorption Calorimeter (TASC); one can expect sensitive range of nine orders of magnitude for GRBs inside the IMC's FOV of about 1.8 str. We present current status of our study including preliminary experimental results for LaBr3 (Ce) using a proton accelerator, and the design and expected ability of CALET-GBM.

  1. Speech rhythm sensitivity and musical aptitude: ERPs and individual differences.

    Science.gov (United States)

    Magne, Cyrille; Jordan, Deanna K; Gordon, Reyna L

    2016-02-01

    This study investigated the electrophysiological markers of rhythmic expectancy during speech perception. In addition, given the large literature showing overlaps between cognitive and neural resources recruited for language and music, we considered a relation between musical aptitude and individual differences in speech rhythm sensitivity. Twenty adults were administered a standardized assessment of musical aptitude, and EEG was recorded as participants listened to sequences of four bisyllabic words for which the stress pattern of the final word either matched or mismatched the stress pattern of the preceding words. Words with unexpected stress patterns elicited an increased fronto-central mid-latency negativity. In addition, rhythm aptitude significantly correlated with the size of the negative effect elicited by unexpected iambic words, the least common type of stress pattern in English. The present results suggest shared neurocognitive resources for speech rhythm and musical rhythm.

  2. Puzzled by GRB 060218

    CERN Document Server

    Ghisellini, G; Tavecchio, F

    2006-01-01

    We study the optical-UV/X-ray spectral energy distribution of GRB 060218 during the prompt phase and during what seems to be the afterglow phase. The results are puzzling, since if the opt-UV and the X-ray emission belong to a single black body, then its luminosity is too large, and it cannot be interpreted as the signature of the supernova shock breakout. Problems are also encountered in associating the expected supernova shock breakout emission with either the opt-UV or the X-ray emission. In the former case we derive too small ejecta velocities; in the latter case, on the contrary, the required velocity is too large. We then present what we think is the most conservative alternative explanation, namely a synchrotron spectrum, self-absorbed in the opt-UV and extending up to the X-ray band, where we observe the emission of the most energetic electrons, which are responsible for the exponential roll-over of the spectrum. The fit to the data is quite satisfactory, and can explain the entire spectrum except the...

  3. The Redshift of GRB 970508

    CERN Document Server

    Reichart, D E

    1997-01-01

    GRB 970508 is the second gamma-ray burst (GRB) for which an optical afterglow has been detected. It is the first GRB for which a distance scale has been determined: absorption and emission features in spectra of the optical afterglow place GRB 970508 at a redshift of z >= 0.835 (Metzger et al. 1997a, 1997b). The lack of a Lyman-alpha forest in these spectra further constrains this redshift to be less than approximately 2.3. I show that the spectrum of the optical afterglow of GRB 970508, once corrected for Galactic absorption, is inconsistent with the relativistic blast-wave model unless a second, redshifted source of extinction is introduced. This second source of extinction may be the yet unobserved host galaxy. I determine its redshift to be z = 1.09^{+0.14}_{-0.41}, which is consistent with the observed redshift of z = 0.835. Redshifts greater than z = 1.40 are ruled out at the 3 sigma confidence level.

  4. GRB 060218 and the binaries as progenitors of GRB-SN systems

    CERN Document Server

    Dainotti, Maria Giovanna; Bianco, Carlo Luciano; Caito, Letizia; Guida, Roberto; Ruffini, Remo

    2007-01-01

    (shortened) We study the Gamma-Ray Burst (GRB) 060218: a particularly close source at z=0.033 with an extremely long duration, namely T_{90} ~ 2000 s, related to SN 2006aj. [...] I present the fitting time consuming procedure. In order to show its sensitivity I also present two examples of fits with the same value of B and different value of E_{e^\\pm}^{tot}. We fit the X- and \\gamma-ray observations by Swift of GRB 060218 in the 0.1-150 keV energy band during the entire time of observations from 0 all the way to 10^6 s within a unified theoretical model. The free parameters of our theory are only three, namely the total energy E_{e\\pm}^{tot} of the e^\\pm plasma, its baryon loading B \\equiv M_Bc^2/E_{e\\pm}^{tot}, as well as the CircumBurst Medium (CBM) distribution. We justify the extremely long duration of this GRB by a total energy E_{e\\pm}^{tot} = 2.32\\times 10^{50} erg, a very high value of the baryon loading B=1.0\\times 10^{-2} and the effective CircumBurst Medium (CBM) density which shows a radial depend...

  5. GRB Flares: UV/Optical Flaring (Paper I)

    CERN Document Server

    Swenson, C A; De Pasquale, M; Oates, S R

    2013-01-01

    We present a new algorithm for the detection of flares in gamma-ray burst (GRB) light curves and use this algorithm to detect flares in the UV/optical. The algorithm makes use of the Bayesian Information Criterion (BIC) to analyze the residuals of the fitted light curve, removing all major features, and to determine the statistically best fit to the data by iteratively adding additional `breaks' to the light curve. These additional breaks represent the individual components of the detected flares: T_start, T_stop, and T_peak. We present the detection of 119 unique flaring periods detected by applying this algorithm to light curves taken from the Second Swift Ultraviolet/Optical Telescope (UVOT) GRB Afterglow Catalog. We analyzed 201 UVOT GRB light curves and found episodes of flaring in 68 of the light curves. For those light curves with flares, we find an average number of ~2 flares per GRB. Flaring is generally restricted to the first 1000 seconds of the afterglow, but can be observed and detected beyond 10...

  6. The distribution of equivalent widths in long GRB afterglow spectra

    CERN Document Server

    Postigo, A de Ugarte; Thoene, C C; Christensen, L; Gorosabel, J; Milvang-Jensen, B; Schulze, S; Jakobsson, P; Wiersema, K; Sanchez-Ramirez, R; Leloudas, G; Zafar, T; Malesani, D; Hjorth, J

    2012-01-01

    The extreme brightness of gamma-ray burst (GRB) afterglows and their simple spectral shape make them ideal beacons to study the interstellar medium of their host galaxies through absorption line spectroscopy. Using 69 low-resolution GRB afterglow spectra, we conduct a study of the rest-frame equivalent width (EW) distribution of features with an average rest-frame EW larger than 0.5 A. To compare an individual GRB with the sample, we develop EW diagrams as a graphical tool, and we give a catalogue with diagrams for the 69 spectra. We introduce a line strength parameter (LSP) that allows us to quantify the strength of the absorption features as compared to the sample by a single number. Using the distributions of EWs of single-species features, we derive the distribution of column densities by a curve of growth (CoG) fit. We find correlations between the LSP and the extinction of the GRB, the UV brightness of the host galaxies and the neutral hydrogen column density. However, we see no significant evolution of...

  7. Patch test dose-response study: polysensitized individuals do not express lower elicitation thresholds than single/double-sensitized individuals.

    Science.gov (United States)

    Carlsen, B C; Fischer, L A; Sosted, H; Vølund, A; Menné, T; Johansen, J D

    2009-01-01

    It is not known if reduced elicitation thresholds are evident among polysensitized individuals when using allergens to which the patients are already sensitized. Reduced elicitation thresholds may be an expression of increased reactivity in this patient group. To examine and compare elicitation dose-response curves and elicitation thresholds in a polysensitized vs. a single/double-sensitized group for allergens to which the test subjects were already sensitized. Fifty-one patients (13 polysensitized and 38 single/double-sensitized) were patch tested with nickel sulphate, methyldibromo glutaronitrile (MDBGN) and p-phenylenediamine (PPD) in dilution series. The ratio between the doses eliciting a response in 50% of patients in the two groups was used as the measure for relative sensitivity. The dose-response curves of the polysensitized group for MDBGN and PPD were shifted to the right, and for nickel sulphate shifted to the left, compared with the single/double-sensitized group. The relative sensitivity for each of the three allergens and a combined relative sensitivity for all three allergens were not significantly different when comparing the polysensitized and single/double-sensitized groups. No increased sensitivity, in the form of distinct elicitation thresholds, could be demonstrated in polysensitized individuals compared with individuals with one or two contact allergies.

  8. A central role for GRB10 in regulation of islet function in man.

    Directory of Open Access Journals (Sweden)

    Inga Prokopenko

    2014-04-01

    Full Text Available Variants in the growth factor receptor-bound protein 10 (GRB10 gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin signaling and imprinted in a parent-of-origin fashion in different tissues. GRB10 knock-down in human pancreatic islets showed reduced insulin and glucagon secretion, which together with changes in insulin sensitivity may explain the paradoxical reduction of glucose despite a decrease in insulin secretion. Together, these findings suggest that tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism and contribute to T2D pathogenesis. The data also emphasize the need in genetic studies to consider whether risk alleles are inherited from the mother or the father.

  9. A Central Role for GRB10 in Regulation of Islet Function in Man

    Science.gov (United States)

    Prasad B, Rashmi; Salehi, S. Albert; Almgren, Peter; Osmark, Peter; Bouatia-Naji, Nabila; Wierup, Nils; Fall, Tove; Stančáková, Alena; Barker, Adam; Lagou, Vasiliki; Osmond, Clive; Xie, Weijia; Lahti, Jari; Jackson, Anne U.; Cheng, Yu-Ching; Liu, Jie; O'Connell, Jeffrey R.; Blomstedt, Paul A.; Fadista, Joao; Alkayyali, Sami; Dayeh, Tasnim; Ahlqvist, Emma; Taneera, Jalal; Lecoeur, Cecile; Kumar, Ashish; Hansson, Ola; Hansson, Karin; Voight, Benjamin F.; Kang, Hyun Min; Levy-Marchal, Claire; Vatin, Vincent; Palotie, Aarno; Syvänen, Ann-Christine; Mari, Andrea; Weedon, Michael N.; Loos, Ruth J. F.; Ong, Ken K.; Nilsson, Peter; Isomaa, Bo; Tuomi, Tiinamaija; Wareham, Nicholas J.; Stumvoll, Michael; Widen, Elisabeth; Lakka, Timo A.; Langenberg, Claudia; Tönjes, Anke; Rauramaa, Rainer; Kuusisto, Johanna; Frayling, Timothy M.; Froguel, Philippe; Walker, Mark; Eriksson, Johan G.; Ling, Charlotte; Kovacs, Peter; Ingelsson, Erik; McCarthy, Mark I.; Shuldiner, Alan R.; Silver, Kristi D.; Laakso, Markku; Groop, Leif; Lyssenko, Valeriya

    2014-01-01

    Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin signaling and imprinted in a parent-of-origin fashion in different tissues. GRB10 knock-down in human pancreatic islets showed reduced insulin and glucagon secretion, which together with changes in insulin sensitivity may explain the paradoxical reduction of glucose despite a decrease in insulin secretion. Together, these findings suggest that tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism and contribute to T2D pathogenesis. The data also emphasize the need in genetic studies to consider whether risk alleles are inherited from the mother or the father. PMID:24699409

  10. The supernova associated with GRB 020405

    CERN Document Server

    Dado, S; De Rújula, Alvaro; Dado, Shlomo; Dar, Arnon; Rujula, Alvaro De

    2002-01-01

    We used the very simple and successful Cannonball (CB) model of gamma ray bursts (GRBs) and their afterglows (AGs) to analyze the observations of the mildly extinct optical AG of the relatively nearby GRB 020405, first made with ground-based telescopes, and with the HST at later times. We show that GRB 020405 was associated with a 1998bw-like supernova (SN) at the GRB's redshift which appeared dimmer and red relative to SN1998bw because of extinction in the host and our Galaxy. The case for the SN/GRB association --advocated in the CB model-- is becoming indubitable.

  11. A Trio of GRB-SNe: GRB 120729A, GRB 130215A / SN 2013ez and GRB 130831A / SN 2013fu

    CERN Document Server

    Cano, Z; Pozanenko, A; Butler, N; Thone, C C; Guidorzi, C; Kruhler, T; Gorosabel, J; Jakobsson, P; Leloudas, G; Malesani, D; Hjorth, J; Melandri, A; Mundell, C; Wiersema, K; D'Avanzo, P; Schulze, S; Gomboc, A; Johansson, A; Zheng, W; Kann, D A; Knust, F; Varela, K; Akerlof, C W; Bloom, J; Burkhonov, O; Cooke, E; de Diego, J A; Dhungana, G; Farina, C; Ferrante, F V; Flewelling, H A; Fox, O D; Fynbo, J; Gehrels, N; Georgiev, L; Gonzalez, J J; Greiner, J; Guver, T; Hartoog, O; Hatch, N; Jelinek, M; Kehoe, R; Klose, S; Klunko, E; Kopac, D; Kutyrev, A; Krugl, Y; Lee, W H; Levan, A; Linkov, V; Matkin, A; Minikulov, N; Molotov, I; Prochaska, J Xavier; Richer, M G; Roman-Zuniga, C G; Rumyantsev, V; Sanchez-Ramirez, R; Steele, I; Tanvir, N R; Volnova, A; Watson, A M; Xu, D; Yuan, F

    2014-01-01

    We present optical and near-infrared (NIR) photometry for three gamma-ray burst supernovae (GRB-SNe): GRB 120729A, GRB 130215A / SN 2013ez and GRB 130831A / SN 2013fu. In the case of GRB 130215A / SN 2013ez, we also present optical spectroscopy at t-t0=16.1 d, which covers rest-frame 3000-6250 Angstroms. Based on Fe II (5169) and Si (II) (6355), our spectrum indicates an unusually low expansion velocity of 4000-6350 km/s, the lowest ever measured for a GRB-SN. Additionally, we determined the brightness and shape of each accompanying SN relative to a template supernova (SN 1998bw), which were used to estimate the amount of nickel produced via nucleosynthesis during each explosion. We find that our derived nickel masses are typical of other GRB-SNe, and greater than those of SNe Ibc that are not associated with GRBs. For GRB 130831A / SN 2013fu, we use our well-sampled R-band light curve (LC) to estimate the amount of ejecta mass and the kinetic energy of the SN, finding that these too are similar to other GRB-...

  12. Hydrodynamic Evolution of GRB Afterglow

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    We investigate the dynamics of a relativistic fireball which decelerates as it sweeps up ambient matter. Not only the radiative and adiabatic cases, but also the realistic intermediate cases are calculated. We perform numerical calcula-tion for various ambient media and sizes of beaming expansion, and find that the deceleration radius R0 may play an important role for the hydrodynamic evolution of GRB afterglow.

  13. Coherent Motion Sensitivity Predicts Individual Differences in Subtraction

    Science.gov (United States)

    Boets, Bart; De Smedt, Bert; Ghesquiere, Pol

    2011-01-01

    Recent findings suggest deficits in coherent motion sensitivity, an index of visual dorsal stream functioning, in children with poor mathematical skills or dyscalculia, a specific learning disability in mathematics. We extended these data using a longitudinal design to unravel whether visual dorsal stream functioning is able to "predict"…

  14. The ultraluminous GRB 110918A

    CERN Document Server

    Frederiks, D D; Svinkin, D S; Pal'shin, V D; Mangano, V; Oates, S; Aptekar, R L; Golenetskii, S V; Mazets, E P; Oleynik, Ph P; Tsvetkova, A E; Ulanov, M V; Kokomov, A V; Cline, T L; Burrows, D N; Krimm, H A; Pagani, C; Sbarufatti, B; Siegel, M H; Mitrofanov, I G; Golovin, D; Litvak, M L; Sanin, A B; Boynton, W; Fellows, C; Harshman, K; Enos, H; Starr, R; von Kienlin, A; Rau, A; Zhang, X; Goldstein, J

    2013-01-01

    GRB 110918A is the brightest long GRB detected by Konus-WIND during its 19 years of continuous observations and the most luminous GRB ever observed since the beginning of the cosmological era in 1997. We report on the final IPN localization of this event and its detailed multiwavelength study with a number of space-based instruments. The prompt emission is characterized by a typical duration, a moderare $E_{peak}$ of the time-integrated spectrum, and strong hard-to-soft evolution. The high observed energy fluence yields, at z=0.984, a huge isotropic-equivalent energy release $E_{iso}=(2.1\\pm0.1)\\times10^{54}$ erg. The record-breaking energy flux observed at the peak of the short, bright, hard initial pulse results in an unprecedented isotropic-equivalent luminosity $L_{iso}=(4.7\\pm0.2)\\times10^{54}$erg s$^{-1}$. A tail of the soft gamma-ray emission was detected with temporal and spectral behavior typical of that predicted by the synchrotron forward-shock model. Swift/XRT and Swift/UVOT observed the bright af...

  15. A trio of gamma-ray burst supernovae:. GRB 120729A, GRB 130215A/SN 2013ez, and GRB 130831A/SN 2013fu

    NARCIS (Netherlands)

    Cano, Z.; et al., [Unknown; Hartoog, O.

    2014-01-01

    We present optical and near-infrared (NIR) photometry for three gamma-ray burst supernovae (GRB-SNe): GRB 120729A, GRB 130215A/SN 2013ez, and GRB 130831A/SN 2013fu. For GRB 130215A/SN 2013ez, we also present optical spectroscopy at t − t0 = 16.1 d, which covers rest-frame 3000-6250 Å. Based on Fe ii

  16. Sensitivity of alpha band ERD to individual differences in cognition.

    Science.gov (United States)

    Neubauer, Aljoscha C; Fink, Andreas; Grabner, Roland H

    2006-01-01

    According to the neural efficiency hypothesis, brighter individuals might be characterized by lower and topographically more differentiated brain activation than less intelligent individuals, presumably reflecting a more specialized recruitment of task-related areas. The findings of several studies analyzing the event-related desynchronization (ERD) in the (upper) alpha frequency band have corroborated and elaborated the original neural efficiency hypothesis. In this chapter, we review classical and recent findings and argue in favor of a more differentiated picture of this phenomenon, emphasizing the role of participants' sex, task complexity, and material specificity, as well as the importance to select an adequate external criterion (intelligence measure). Also, recent ERD findings related to emotional intelligence and creativity as well as recent studies focusing on practice, learning ability, and expertise are presented, which point to the need of a broader neurophysiological ability concept. The reviewed findings point at the high suitability of the ERD method to uncover consistent and stable individual differences in people's brain activation patterns when engaged in performing cognitively demanding tasks.

  17. Study of WATCH GRB error boxes

    DEFF Research Database (Denmark)

    Gorosabel, J.; Castro-Tirado, A. J.; Lund, Niels

    1995-01-01

    We have studied the first WATCH GRB Catalogue ofγ-ray Bursts in order to find correlations between WATCH GRB error boxes and a great variety of celestial objects present in 33 different catalogues. No particular class of objects has been found to be significantly correlated with the WATCH GRBs....

  18. Challenging GRB models through the broadband dataset of GRB060908

    CERN Document Server

    Covino, S; Conciatore, M L; D'Elia, V; Palazzi, E; Thöne, C C; Vergani, S D; Wiersema, K; Brusasca, M; Cucchiara, A; Cobb, B E; Fernandez-Soto, A; Kann, D A; Malesani, D; Tanvir, N R; Antonelli, L A; Bremer, M; Castro-Tirado, A J; Postigo, A de Ugarte; Molinari, E; Nicastro, L; Stefanon, M; Testa, V; Tosti, G; Vitali, F; Amati, L; Chapman, R; Conconi, P; Cutispoto, G; Fynbo, J P U; Goldoni, P; Henriksen, C; Horne, K D; Malaspina, G; Meurs, E J A; Pian, E; Stella, L; Tagliaferri, G; Ward, P; Zerbi, F M

    2010-01-01

    Context: Multiwavelength observations of gamma-ray burst prompt and afterglow emission are a key tool to disentangle the various possible emission processes and scenarios proposed to interpret the complex gamma-ray burst phenomenology. Aims: We collected a large dataset on GRB060908 in order to carry out a comprehensive analysis of the prompt emission as well as the early and late afterglow. Methods: Data from Swift-BAT, -XRT and -UVOT together with data from a number of different ground-based optical/NIR and millimeter telescopes allowed us to follow the afterglow evolution from about a minute from the high-energy event down to the host galaxy limit. We discuss the physical parameters required to model these emissions. Results: The prompt emission of GRB060908 was characterized by two main periods of activity, spaced by a few seconds of low intensity, with a tight correlation between activity and spectral hardness. Observations of the afterglow began less than one minute after the high-energy event, when it ...

  19. The ultraluminous GRB 110918A

    Energy Technology Data Exchange (ETDEWEB)

    Frederiks, D. D.; Svinkin, D. S.; Pal' shin, V. D.; Aptekar, R. L.; Golenetskii, S. V.; Mazets, E. P.; Oleynik, Ph. P.; Tsvetkova, A. E.; Ulanov, M. V.; Kokomov, A. A. [Ioffe Physical-Technical Institute, Politekhnicheskaya 26, St. Petersburg 194021 (Russian Federation); Hurley, K. [Space Sciences Laboratory, University of California, 7 Gauss Way, Berkeley, CA 94720-7450 (United States); Mangano, V.; Burrows, D. N.; Sbarufatti, B.; Siegel, M. H. [Pennsylvania State University, Department of Astronomy and Astrophysics, College Park, PA 16801 (United States); Oates, S. [Mullard Space Science Laboratory, University College London, Holmbury St. Mary, Dorking, Surrey RH5 6NT (United Kingdom); Cline, T. L.; Krimm, H. A. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Pagani, C. [University of Leicester, University Road, Leicester LE1 7RH (United Kingdom); Mitrofanov, I. G., E-mail: fred@mail.ioffe.ru [Space Research Institute, Profsoyuznaya 84/32, Moscow 117997 (Russian Federation); and others

    2013-12-20

    GRB 110918A is the brightest long gamma-ray burst (GRB) detected by Konus-WIND during its almost 19 yr of continuous observations and the most luminous GRB ever observed since the beginning of the cosmological era in 1997. We report on the final Interplanetary Network localization of this event and its detailed multiwavelength study with a number of space-based instruments. The prompt emission is characterized by a typical duration, a moderate peak energy of the time-integrated spectrum, and strong hard-to-soft evolution. The high observed energy fluence yields, at z = 0.984, a huge isotropic-equivalent energy release E {sub iso} = (2.1 ± 0.1) × 10{sup 54} erg. The record-breaking energy flux observed at the peak of the short, bright, hard initial pulse results in an unprecedented isotropic-equivalent luminosity L {sub iso} = (4.7 ± 0.2) × 10{sup 54} erg s{sup –1}. A tail of the soft γ-ray emission was detected with temporal and spectral behavior typical of that predicted by the synchrotron forward-shock model. The Swift/X-Ray Telescope and the Swift/Ultraviolet Optical Telescope observed the bright afterglow from 1.2 to 48 days after the burst and revealed no evidence of a jet break. The post-break scenario for the afterglow is preferred from our analysis, with a hard underlying electron spectrum and interstellar-medium-like circumburst environment implied. We conclude that, among the multiple reasons investigated, the tight collimation of the jet must have been a key ingredient to produce this unusually bright burst. The inferred jet opening angle of 1.°7-3.°4 results in reasonable values of the collimation-corrected radiated energy and the peak luminosity, which, however, are still at the top of their distributions for such tightly collimated events. We estimate a detection horizon for a similar ultraluminous GRB of z ∼ 7.5 for Konus-WIND and z ∼ 12 for the Swift/Burst Alert Telescope, which stresses the importance of GRBs as probes of the early

  20. Hypervigilance to Rejecting Stimuli in Rejection Sensitive Individuals: Behavioral and Neurocognitive Evidence.

    Science.gov (United States)

    Ehrlich, Katherine B; Gerson, Sarah A; Vanderwert, Ross E; Cannon, Erin N; Fox, Nathan A

    2015-10-01

    Individuals who are high in rejection sensitivity are vigilant toward social cues that signal rejection, and they exhibit attention biases towards information that confirms expectations of rejection. Little is known, however, about the neural correlates of rejection sensitivity. The present study examined whether rejection sensitivity is associated with individuals' neural responses to rejection-relevant information. Female participants, classified as high or average in rejection sensitivity, completed a modified dot-probe task in which a neutral face was paired with either another neutral face or a gaze-averted ("rejecting") face while EEG was collected and ERP components were computed. Behavioral results indicated that average rejection sensitive participants showed an attention bias away from rejecting faces, while high rejection sensitive participants were equally vigilant to neutral and rejecting faces. High rejection sensitivity was associated with ERP components signaling elevated attention and arousal to faces. These findings suggest that rejection sensitivity shapes behavioral and neurocognitive responses to faces.

  1. Type 2 Diabetes Risk Alleles Near BCAR1 and in ANK1 Associate With Decreased β-Cell Function Whereas Risk Alleles Near ANKRD55 and GRB14 Associate With Decreased Insulin Sensitivity in the Danish Inter99 Cohort

    DEFF Research Database (Denmark)

    Harder, Marie Neergaard; Ribel-Madsen, Rasmus; Justesen, Johanne Marie

    2013-01-01

    insulinogenic (P = .005) and disposition (P = .002) indexes. The G allele of ANKRD55 rs459193 associated with decreased Matsuda index (P = .02) adjusted for waist circumference. The C allele of GRB14 rs13389219 associated with both increased insulinogenic (P = .04) and decreased Matsuda (P = .05) indexes. All...... insulinogenic, disposition, BIGTT, and Matsuda indexes.Results:We confirmed associations of ZMIZ1, KLHDC5, CILP2, HMG20A, ANK1, ANKRD55, and BCAR1 with T2D. The risk T allele of BCAR1 rs7202877 associated with decreased disposition index (P = .02). The C allele of ANK1 rs516946 associated with decreased...

  2. Patch test dose-response study: polysensitized individuals do not express lower elicitation thresholds than single/double-sensitized individuals

    DEFF Research Database (Denmark)

    Carlsen, B C; Fischer, Louise Arup; Sosted, H

    2009-01-01

    BACKGROUND: It is not known if reduced elicitation thresholds are evident among polysensitized individuals when using allergens to which the patients are already sensitized. Reduced elicitation thresholds may be an expression of increased reactivity in this patient group. OBJECTIVES: To examine a...

  3. Advances on GRB as cosmological tools

    CERN Document Server

    Ghirlanda, G

    2009-01-01

    Several interesting correlations among Gamma Ray Bursts (GRB) prompt and afterglow properties have been found in the recent years. Some of these correlations have been proposed also to standardize GRB energetics to use them as standard candles in constraining the expansion history of the universe up to z>6. However, given the still unexplained nature of most of these correlations, only the less scattered correlations can be used for constraining the cosmological parameters. The updated E_peak-E_gamma correlation is presented. Caveats of alternative methods of standardizing GRB energetics are discussed.

  4. GRB 080913 at redshift 6.7

    DEFF Research Database (Denmark)

    Greiner, J.; Krühler, T.; Fynbo, J. P. U.

    2009-01-01

    We report on the detection by Swift of GRB 080913, and subsequent optical/near-infrared follow-up observations by GROND, which led to the discovery of its optical/NIR afterglow and the recognition of its high-z nature via the detection of a spectral break between the i' and z' bands. Spectroscopy...... obtained at the ESO-VLT revealed a continuum extending down to ¿ = 9400 Å, and zero flux for 7500 Åz = 6.695± 0.025 (95.5% confidence level), making GRB 080913 the highest-redshift gamma-ray burst (GRB) to date, and more distant than...

  5. The Strongly Polarized Afterglow of GRB 020405

    CERN Document Server

    Bersier, D F; Garnavich, P M; Holman, M J; Grav, T; Quinn, J; Kaluzny, J; Challis, P M; Bower, R G; Wilman, D J; Heyl, J S; Holland, S T; Hradecky, V; Jha, S; Stanek, K Z

    2003-01-01

    We report polarization measurements and photometry for the optical afterglow of the gamma-ray burst GRB 020405. We measured a highly significant 9.9% polarization (in V band) 1.3 days after the burst and argue that it is intrinsic to the GRB. The light curve decay is well fitted by a $t^{-1.72}$ power-law; we do not see any evidence for a break between 1.24 and 4.3 days after the burst. We discuss these measurements in the light of several models of GRB afterglows.

  6. GRB 030227: The first multiwavelength afterglow of an INTEGRAL GRB

    DEFF Research Database (Denmark)

    Castro-Tirado, A.J.; Gorosabel, J.; Guziy, S.

    2003-01-01

    We present multiwavelength observations of a gamma-ray burst detected by INTEGRAL (GRB 030227) between 5.3 hours and similar to1.7 days after the event. Here we report the discovery of a dim optical afterglow (OA) that would not have been detected by many previous searches due to its faintess (R...... similar to 23). This OA was seen to decline following a power law decay with index alpha(R) = - 0.95 +/- 0.16. The spectral index beta(opt/NIR) yielded - 1.25 +/- 0.14. These values may be explained by a relativistic expansion of a fireball ( with p = 2.0) in the cooling regime. We also find evidence...... for inverse Compton scattering in X-rays....

  7. Pulse-wise GRB correlation: implication as a cosmological tool

    CERN Document Server

    Basak, Rupal

    2016-01-01

    Gamma-ray bursts (GRBs) are cosmological explosions which carry valuable information from the distant past of the expanding universe. One of the greatest discoveries in modern cosmology is the finding of the accelerated expansion of the universe using Type Ia supernovae (SN Ia) as standard candles. However, due to the interstellar extinction SN Ia can be seen only up to a redshift $z\\sim 1.5$. GRBs are considered as the potential alternative to push this limit to as high as $z\\sim 10$, a redshift regime corresponding to an epoch when the universe just started to form the first structures. There exist several correlations between the energy and an observable of a GRB which can be used to derive luminosity distance. In recent works, we have studied spectral evolution within the individual pulses and obtained such correlations within the pulses. Here we summarize our results of the pulse-wise GRB correlation study. It is worth mentioning that all GRB correlations are still empirical, and we cannot use them in co...

  8. LEAP - A Large Area GRB Polarimeter for the ISS

    Science.gov (United States)

    McConnell, Mark L.; Baring, Matthew G.; Bloser, Peter F.; Briggs, Michael Stephen; Connaughton, Valerie; Dwyer, Joseph; Gaskin, Jessica; Grove, J. Eric; Gunji, Shuichi; Hartmann, Dieter; Hayashida, Kiyoshi; Hill, Joanne E.; Kippen, R. Marc; Kishimoto, Shunji; Kishimoto, Yuji; Krizmanic, John F.; Lundman, Christoffer; Mattingly, David; McBreen, Sheila; Meegan, Charles A.; Mihara, Tatehiro; Nakamori, Takeshi; Pearce, Mark; Phlips, Bernard; Preece, Robert D.; Produit, Nicolas; Ryan, James M.; Ryde, Felix; Sakamoto, Takanori; Strickman, Mark Samuel; Sturner, Steven J.; Takahashi, Hiromitsu; Toma, Kenji; Vestrand, W. Thomas; Wilson-Hodge, Colleen A.; yatsu, Yoichi; Yonetoku, Daisuke; Zhang, Bing

    2017-08-01

    The LargE Area burst Polarimeter (LEAP) is a mission concept for a wide FOV Compton scatter polarimeter instrument that would be mounted as an external payload on the International Space Station (ISS) in 2022. It has recently been proposed as an astrophysics Mission of Opportunity (MoO), with the primary objective of measuring polarization of the prompt emission of Gamma Ray Bursts (GRBs). It will achieve its science objectives with a simple mission design that features a single instrument based entirely on well-established, flight-proven scintillator-photomultiplier tube (PMT) technologies. LEAP will provide GRB polarization measurements from 30-500 keV and GRB spectroscopy from 5 keV up to 5 MeV, and will self-sufficiently provide the source localization that is required for analysis of the polarization data. The instrument consists of 9 independent polarimeter modules and associated electronics. Each module is a 12 x 12 array of independent plastic and CsI(Tl) scintillator elements, each with individual PMT readout, to identify and measure Compton scatter events. It will provide coverage of GRB spectra over a range that includes most values of Ep. With a total geometric scintillator area of 5000 cm2, LEAP will provide a total effective area for polarization (double scatter) events of ~500 cm2. LEAP will trigger on >200 GRBs within its FOV during a two-year mission. At least 120 GRBs will have sufficient counts to enable localization with an error of 50%, as suggested by published results, LEAP will provide definitive polarization measurements on ~100 GRBs. These data will allow LEAP to differentiate between the intrinsic and geometric classes of GRB models and further distinguish between two geometric models at the 95% confidence level. Detailed time-resolved and/or energy-resolved studies will be conducted for the brightest GRBs.

  9. Heightened Olfactory Sensitivity in Young Females with Recent-Onset Anorexia Nervosa and Recovered Individuals

    DEFF Research Database (Denmark)

    Bentz, Mette; Guldberg, Johanne; Vangkilde, Signe

    2017-01-01

    INTRODUCTION: Olfaction may be related to food restriction and weight loss. However, reports regarding olfactory function in individuals with anorexia nervosa (AN) have been inconclusive. OBJECTIVE: Characterize olfactory sensitivity and identification in female adolescents and young adults...

  10. Heightened Olfactory Sensitivity in Young Females with Recent-Onset Anorexia Nervosa and Recovered Individuals

    DEFF Research Database (Denmark)

    Bentz, Mette; Guldberg, Johanne; Vangkilde, Signe

    2017-01-01

    INTRODUCTION: Olfaction may be related to food restriction and weight loss. However, reports regarding olfactory function in individuals with anorexia nervosa (AN) have been inconclusive. OBJECTIVE: Characterize olfactory sensitivity and identification in female adolescents and young adults...

  11. Individual Values and Sensitivity to Corporate Ethical Responsibility of Business Students and Managers

    NARCIS (Netherlands)

    Perrinjaquet, A.; Furrer, O.F.G.

    2005-01-01

    This study investigates the relationship between individual values and sensitivity to corporate ethical responsibility (CER) among current business students and practicing managers. Using Schwartz’s values typology and Maignan and Ferrell’s corporate ethical responsibility operationalization, survey

  12. Trait-Based Individual Differences on Discomfort Glare Rating Responses and Related Visual Contrast Sensitivity

    OpenAIRE

    Mekaroonreung, Haruetai

    2003-01-01

    This research was designed to investigate the relationship between Trait-based Individual differences (neuroticism and extraversion) and glare subjective responses as well as the actual contrast sensitivity when exposed to the same manipulated glare condition. In addition, the relationship between the glare subjective responses and actual contrast sensitivity was investigated. To examine the trait-based individual differences, the International Personality Item Pool (IPIP) was used while th...

  13. GRB 130427A: a Nearby Ordinary Monster

    CERN Document Server

    Maselli, A; Nava, L; Mundell, C G; Kawai, N; Campana, S; Covino, S; Cummings, J R; Cusumano, G; Evans, P A; Ghirlanda, G; Ghisellini, G; Guidorzi, C; Kobayashi, S; Kuin, P; La Parola, V; Mangano, V; Oates, S; Sakamoto, T; Serino, M; Virgili, F; Zhang, B -B; Barthelmy, S; Beardmore, A; Bernardini, M G; Bersier, D; Burrows, D; Calderone, G; Capalbi, M; Chiang, J; D'Avanzo, P; D'Elia, V; De Pasquale, M; Fugazza, D; Gehrels, N; Gomboc, A; Harrison, R; Hanayama, H; Japelj, J; Kennea, J; Kopac, D; Kouveliotou, C; Kuroda, D; Levan, A; Malesani, D; Marshall, F; Nousek, J; O'Brien, P; Osborne, J P; Pagani, C; Page, K L; Page, M; Perri, M; Pritchard, T; Romano, P; Saito, Y; Sbarufatti, B; Salvaterra, R; Steele, I; Tanvir, N; Vianello, G; Weigand, B; Wiersema, K; Yatsu, Y; Yoshii, T; Tagliaferri, G

    2014-01-01

    Long-duration Gamma-Ray Bursts (GRBs) are an extremely rare outcome of the collapse of massive stars, and are typically found in the distant Universe. Because of its intrinsic luminosity ($L\\sim 3 \\times 10^{53}$ erg s$^{-1}$) and its relative proximity ($z=0.34$), GRB 130427A was a unique event that reached the highest fluence observed in the gamma-ray band. Here we present a comprehensive multiwavelength view of GRB 130427A with Swift, the 2-m Liverpool and Faulkes telescopes and by other ground-based facilities, highlighting the evolution of the burst emission from the prompt to the afterglow phase. The properties of GRB 130427A are similar to those of the most luminous, high-redshift GRBs, suggesting that a common central engine is responsible for producing GRBs in both the contemporary and the early Universe and over the full range of GRB isotropic energies.

  14. GRB 130427A: A Nearby Ordinary Monster

    Science.gov (United States)

    Maselli, A.; Melandri, A.; Nava, L.; Mundell, C. G.; Kawai, N.; Campana, S.; Covino, S.; Cummings, J. R.; Cusumano, G.; Evans, P. A.; Ghirlanda, G.; Ghisellini, G.; Guidorzi, C.; Kobayashi, S.; Kuin, P.; La Parola, V.; Mangano, V.; Oates, S.; Sakamoto, T.; Serino, M.; Virgili, F.; Zhang, B.-B.; Barthelmy, S.; Beardmore, A.; Bernardini, M. G.; Bersier, D.; Burrows, D.; Calderone, G.; Capalbi, M.; Chiang, J.; D'Avanzo, P.; D'Elia, V.; De Pasquale, M.; Fugazza, D.; Gehrels, N.; Gomboc, A.; Harrison, R.; Hanayama, H.; Japelj, J.; Kennea, J.; Kopac, D.; Kouveliotou, C.; Kuroda, D.; Levan, A.; Malesani, D.; Marshall, F.; Nousek, J.; O'Brien, P.; Osborne, J. P.; Pagani, C.; Page, K. L.; Page, M.; Perri, M.; Pritchard, T.; Romano, P.; Saito, Y.; Sbarufatti, B.; Salvaterra, R.; Steele, I.; Tanvir, N.; Vianello, G.; Weigand, B.; Wiersema, K.; Yatsu, Y.; Yoshii, T.; Tagliaferri, G.

    2014-01-01

    Long-duration gamma-ray bursts (GRBs) are an extremely rare outcome of the collapse of massive stars and are typically found in the distant universe. Because of its intrinsic luminosity (L ˜ 3 × 1053 ergs per second) and its relative proximity (z = 0.34), GRB 130427A reached the highest fluence observed in the γ-ray band. Here, we present a comprehensive multiwavelength view of GRB 130427A with Swift, the 2-meter Liverpool and Faulkes telescopes, and by other ground-based facilities, highlighting the evolution of the burst emission from the prompt to the afterglow phase. The properties of GRB 130427A are similar to those of the most luminous, high-redshift GRBs, suggesting that a common central engine is responsible for producing GRBs in both the contemporary and the early universe and over the full range of GRB isotropic energies.

  15. Magnetic energy injection in GRB 080913

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    GRB 080913,with a spectroscopically determined redshift of z=6.7,was the record holder for being the most remote stellar object before the discovery of the recent gamma-ray burst GRB 090423,whose redshift is about 8.2.The gradually accumulated high redshift GRB sample has shed light on the origin and physical properties of GRBs during the cosmic re-ionization epoch.Here,we present a detailed numerical fit to the multi-wavelength data of the optical afterglow of GRB 080913 and then constrain its circumburst environment and the other model parameters.We conclude that the late optical/X-ray plateau at about one day since the burst is due to the Poynting-flux dominated injection from the central engine which is very likely a massive spinning black hole with super strong magnetic fields.

  16. Developing teacher sensitivity to individual learning differences (ILDs) : Studies on increasing teacher effectiveness

    NARCIS (Netherlands)

    Rosenfeld, M.N.

    2008-01-01

    Effective teachers are sensitive to individual learning differences (ILDs). This dissertation investigates teacher changes as a result of eight long-term professional development (PD) courses (56-hours and 28-hours) designed to help them become more sensitive to ILDs. In these courses, the teache

  17. GRB 060117: Reverse + forward shock solution

    CERN Document Server

    Jel'inek, M; Kubánek, P; Hudec, R; Nekola, M F; Rídky, J; Grygar, J; Jel\\'inek, Martin; Prouza, Michael; Kub\\'anek, Petr; Hudec, Ren\\'e; Nekola, Martin F.; Ridky, Jan; Grygar, Jiri

    2007-01-01

    We present a discovery and observation of an extraordinarily bright prompt optical emission of the GRB 060117 obtained by a wide-field camera atop the robotic telescope FRAM of the Pierre Auger Observatory from 2 to 10 minutes after the GRB. We found rapid average temporal flux decay of alpha = -1.7 +/- 0.1 and a peak brightness R = 10.1 mag. We interpret the shape of the lightcurve as a transition between reverse and forward shock emission.

  18. Present and future prospects for GRB standard candles

    Energy Technology Data Exchange (ETDEWEB)

    Friedman, A.S. [Harvard Smithsonian Center for Astrophysics, Cambridge (United States); Bloom, J.S. [California Univ., Berkeley (United States). Department of Astronomy; Harvard Smithsonian Center for Astrophysics, Cambridge (United States)

    2005-07-15

    Following our previous work, we conclude that a GRB standard candle constructed from the Ghirlanda et al. power-law relation between the geometry-corrected energy (E{sub {gamma}}) and the peak of the rest-frame prompt burst spectrum (E{sub p}) is not yet cosmographically useful, despite holding some potential advantages over SNe la, This is due largely to the small sample of {approx} 20 GRBs with the required measured redshifts, jet-breaks, and peak energies, and to the strong sensitivity of the goodness-of-fit of the power-law to input assumptions. The most important such finding concerns the sensitivity to the generally unknown density (and density profile), of the circumburst medium. Although the E{sub p}-E{sub {gamma}} relation is a highly significant correlation over many cosmologies, until the sample expands to include many low-z events, it will be most sensitive to {omega}M but essentially insensitive to {omega}A and w, with some hope of constraining dw/dt with high-z GRB data alone. The relation clearly represents a significant improvement in the search for an empirical GRB standard candle, but is further hindered by an unknown physical basis for the relation, the lack of a low-z training set to calibrate the relation in a cosmology-independent way, and several major potential systematic uncertainties and selection effects, Until these concerns are addressed, a larger sample is acquired, and attempts are made to marginalize or perform Monte Carlo simulations over the unknown density distribution, we urge caution concerning claims of the utility of GRBs for cosmography and especially the attempts to combine GRBs with SNe Ia.

  19. Solving the missing GRB neutrinos and the GRB-SN puzzles

    CERN Document Server

    Fargion, Daniele

    2016-01-01

    We argue that any GRB model where the progenitor is made by high relativistic hadronic interactions shock waves, and later on by electron-pairs feeding gamma jets, is necessarily leading to an average high neutrino over photon fluency ratio well above unity, mostly above several thousands. The present observed average highest energy ICECUBE neutrino energy fluency is at most comparable to the gamma-X in GRB one. Therefore no hadronic GRB, Fireball or even any earliest hadronic thin precessing Jet, may fit the observation. We therefore imagine a novel electronic thin spinning and precessing jet, fed in late binary system, able to avoid the overcrowded neutrino tails foreseen in hadronic GRB models. In some occasion such an electronic model may lead to an explosion that shines during a GRB with an (apparent) late SN-like event.

  20. Testing GRB models with the strange afterglow of GRB 090102

    CERN Document Server

    Gendre, B; Palazzi, E; Kruhler, T; Covino, S; Afonso, P; Antonelli, L A; Atteia, J L; D'Avanzo, P; Boër, M; Greiner, J; Klose, S

    2009-01-01

    We present the observations of the afterglow of gamma-ray burst GRB 090102. We use optical data taken by the TAROT, REM, GROND, Palomar and NOT telescopes, and X-ray data taken by the XRT instrument on board the Swift spacecraft. This event features an unusual light curve. In X-rays, it presents a very monotonic decrease with no hint of temporal break from 0.005 to 6 days after the burst. In optical, the light curve presents a flattening after 1 ks. Before this break, the optical light curve is steeper than the X-ray one. In optical, no further break is observed up to 10 days after the burst. We tried to explain these observations in light of the standard fireball model, but we failed to do so. We then investigated several other models, like the cannonball model. We find that the explanation of the broad band data by any model requires a strong fine tuning when taking into account both optical and X-ray bands.

  1. The LAGO Collaboration: Searching for high energy GRB emissions in Latin America

    Science.gov (United States)

    Barros, H.; Lago Collaboration

    2012-02-01

    During more than a decade Gamma Ray Bursts (GRB a cosmological phenomena of tremendous power) have been extensively studied in the keV - MeV energy range. However, the higher energy emission still remains a mystery. The Large Aperture GRB Observatory (L.A.G.O.) is an international collaboration started in 2005 aiming at a better understanding of the GRB by studying their emission at high energies (> 1 GeV), where the fluxes are low and measurements by satellites are difficult. This is done using the Single Particle Technique, by means of ground-based Water Cherenkov Detectors (WCD) at sites of high altitude. At those altitudes it is possible to detect air showers produced by high energy photons from the GRB, i. e. a higher rate of events on a short time scale, of the order of the second. The Pierre Auger Observatory could detect such GRB given its large number of detectors, but at 1400 m.a.s.l. the expected signal is quite small. At higher altitudes, similar performance is expected with only a very small number of WCD. As of 2011, high altitude WCD are in operation at Sierra Negra (Mexico, 4650 m.a.s.l.), Chacaltaya (Bolivia, 5200 m.a.s.l.), Maracapomacocha (Peru, 4200 m.a.s.l.), and new WCDs are being installed in Venezuela (Pico Espejo, 4750 m.a.s.l.), Argentina, Brazil, Chile, Colombia and Guatemala. Most of the new WCDs will not be at high enough altitude to detect GRB, never the less it will allow obtaining valuable measurements of secondaries at ground level, which are relevant for solar physics. The LAGO sensitivity to GRB is determined from simulations (under a sudden increase of 1 GeV - 1 TeV photons from a GRB) of the gamma initiated particle shower in the atmosphere and the WCD response to secondaries. We report on WDC calibration and operation at high altitude, GRB detectability, background rates, search for bursts in several months of preliminary data, as well as search for signals at ground level when satellite burst is reported, all these show the

  2. Sensitive plant (Mimosa pudica) hiding time depends on individual and state.

    Science.gov (United States)

    Reed-Guy, Sarah; Gehris, Connor; Shi, Meng; Blumstein, Daniel T

    2017-01-01

    The decisions animals make to adjust their antipredator behavior to rapidly changing conditions have been well studied. Inducible defenses in plants are an antipredator behavior that acts on a longer time scale, but sensitive plants, Mimosa pudica, have a much more rapid antipredator response; they temporarily close their leaves when touched. The time they remain closed is defined as hiding time. We studied hiding time in sensitive plants and found that individual plants differed significantly in their hiding times. We then showed that the effect of individual explained substantial variation in hiding time on a short time scale. Finally, on a longer time scale, individuality persisted but the amount of variation attributed to individual decreased. We hypothesized that variation in plant condition might explain this change. We therefore manipulated sunlight availability and quantified hiding time. When deprived of light for 6 h, sensitive plants significantly shortened their hiding times. But when only half a plant was deprived of light, hiding times on the deprived half and light exposed half were not significantly different. This suggests that overall condition best explains variation in sensitive plant antipredator behavior. Just like in animals, sensitive plant antipredator behavior is condition dependent, and, just like in animals, a substantial amount of the remaining variation is explained by individual differences between plants. Thus, models designed to predict plasticity in animal behavior may be successfully applied to understand behavior in other organisms, including plants.

  3. Sensitive plant (Mimosa pudica hiding time depends on individual and state

    Directory of Open Access Journals (Sweden)

    Sarah Reed-Guy

    2017-07-01

    Full Text Available The decisions animals make to adjust their antipredator behavior to rapidly changing conditions have been well studied. Inducible defenses in plants are an antipredator behavior that acts on a longer time scale, but sensitive plants, Mimosa pudica, have a much more rapid antipredator response; they temporarily close their leaves when touched. The time they remain closed is defined as hiding time. We studied hiding time in sensitive plants and found that individual plants differed significantly in their hiding times. We then showed that the effect of individual explained substantial variation in hiding time on a short time scale. Finally, on a longer time scale, individuality persisted but the amount of variation attributed to individual decreased. We hypothesized that variation in plant condition might explain this change. We therefore manipulated sunlight availability and quantified hiding time. When deprived of light for 6 h, sensitive plants significantly shortened their hiding times. But when only half a plant was deprived of light, hiding times on the deprived half and light exposed half were not significantly different. This suggests that overall condition best explains variation in sensitive plant antipredator behavior. Just like in animals, sensitive plant antipredator behavior is condition dependent, and, just like in animals, a substantial amount of the remaining variation is explained by individual differences between plants. Thus, models designed to predict plasticity in animal behavior may be successfully applied to understand behavior in other organisms, including plants.

  4. How the government's punishment and individual's sensitivity affect the rumor spreading in online social networks

    Science.gov (United States)

    Li, Dandan; Ma, Jing

    2017-03-01

    We explore the impact of punishment of governments and sensitivity of individuals on the rumor spreading in this paper. Considering the facts that some rumors that relate to the hot events could be disseminated repeatedly, however, some other rumors will never be disseminated after they have been popular for some time. Therefore, we investigate two types (SIS and SIR) of rumor spreading models in which the punishment of government and sensitivity of individuals are considered. Based on the mean-field method, we have calculated the spreading threshold of SIS and SIR model, respectively. Furthermore, we perform the rumor spreading process in the Facebook and POK social networks, and achieve that there is an excellent agreement between the theoretical and numerical results of spreading threshold. The results indicate that improving the punishment of government and increasing the sensitivity of individuals could control the spreading of rumor effectively.

  5. Analysis of the individual radio sensitivity of breast cancer patients; Untersuchungen zur individuellen Strahlenempfindlichkeit von Brustkrebspatientinnen

    Energy Technology Data Exchange (ETDEWEB)

    Auer, Judith

    2013-04-04

    Individual radiosensitivity has a crucial impact on radiotherapy related side effects. A prediction of individual radiosensitivity could avoid these side effects. Our aim was to study a breast cancer collective for its variation of individual radiosensitivity. Peripheral blood samples were obtained from 129 individuals. 67 breast cancer patients and 62 healthy and age matched individuals were looked at and their individual radiosensitivity was estimated by a 3-color Fluorescence in situ hybridization approach. Blood samples were obtained (i) before starting adjuvant radiotherapy and were in vitro irradiated by 2 Gy; (ii) after 5 single doses of 1.8 Gy and after 72 h had elapsed. DNA of lymphocytes was probed with whole chromosome painting for chromosomes 1, 2 and 4. The rate of breaks per metaphase was analyzed and used as a predictor of individual radiosensitivity. Breast cancer patients were distinctly more radio-sensitive compared to healthy controls. Additionally the distribution of the cancer patients' radiosensitivity was broader. A subgroup of 9 rather radio-sensitive and 9 rather radio-resistant patients was identified. A subgroup of patients aged between 40 and 50 was distinctly more radio-sensitive than younger or older patients. The in vivo irradiation approach was not applicable to detect individual radiosensitivity. In the breast cancer collective a distinctly resistant and sensitive subgroup is identified, which could be subject for treatment adjustment. Especially in the range of age 40 to 50 patients have an increased radiosensitivity. An in vivo irradiation in a breast cancer collective is not suitable to estimate individual radiosensitivity due to a low deposed dose.

  6. The analysis of individual Visegrad group members’ agrarian export sensitivity in relation to selected macroeconomic aggregations

    Directory of Open Access Journals (Sweden)

    Miroslav Svatoš

    2011-01-01

    Full Text Available This paper analyzes the development of agricultural trade of the countries of the Visegrad Group with emphasis on development of the value of agricultural exports of the individual countries. The subject matter of the analysis is the sensitivity of the commodity structure of agricultural exports of individual countries and the identification of aggregations that are the least and the most sensitive to changes to the external and internal economic environment. From the conducted research, agricultural trade in the V4 countries was found to have developed very dynamically from 1993 to 2008, while the commodity structure of exports has constantly narrowed as the degree of specialization of the individual countries has increased (this applies especially to the Czech Republic, Slovakia and Hungary. From the results of analysis of sensitivity to changes of selected variables relating to the development of the value of agricultural exports of the individual V4 countries, it appears that the aggregations that react most sensitively to changes are those that are the subject of re-exports, followed by the aggregations that are characterized by a high degree of added value. In general it can be said that products of agricultural primary production exhibit less sensitivity in comparison with grocery industry products. This is confirmed by the general trend arising from the very nature of consumer behaviour.

  7. Early emission of rising optical afterglows: The case of GRB 060904B and GRB 070420

    CERN Document Server

    Klotz, A; Stratta, G; Galli, A; Corsi, A; Preger, B; Cutini, S; Pelangeon, A; Atteia, J L; Boër, M; Piro, L

    2008-01-01

    We present the time-resolved optical emission of gamma-ray bursts GRB 060904B and GRB 070420 during their prompt and early afterglow phases. We used time resolved photometry from optical data taken by the TAROT telescope and time resolved spectroscopy at high energies from the Swift spacecraft instrument. The optical emissions of both GRBs are found to increase from the end of the prompt phase, passing to a maximum of brightness at t_{peak}=9.2 min and 3.3 min for GRB 060904B and GRB 070420 respectively and then decrease. GRB 060904B presents a large optical plateau and a very large X-ray flare. We argue that the very large X-flare occurring near t_{peak} is produced by an extended internal engine activity and is only a coincidence with the optical emission. GRB 070420 observations would support this idea because there was no X-flare during the optical peak. The nature of the optical plateau of GRB 060904B is less clear and might be related to the late energy injection.

  8. Moral judgment modulation by disgust is bi-directionally moderated by individual sensitivity

    Directory of Open Access Journals (Sweden)

    How Hwee eOng

    2014-03-01

    Full Text Available Modern theories of moral judgment predict that both conscious reasoning and unconscious emotional influences affect the way people decide about right and wrong. In a series of experiments, we tested the effect of subliminal and conscious priming of disgust facial expressions on moral dilemmas. Trolley-car-type scenarios were used, with subjects rating how acceptable they found the utilitarian course of action to be. On average, subliminal priming of disgust facial expressions resulted in higher rates of utilitarian judgments compared to neutral facial expressions. Further, in replication, we found that individual change in moral acceptability ratings due to disgust priming was modulated by individual sensitivity to disgust, revealing a bi-directional function. Our second replication extended this result to show that the function held for both subliminally and consciously presented stimuli. Combined across these experiments, we show a reliable bi-directional function, with presentation of disgust expression primes to individuals with higher disgust sensitivity resulting in more utilitarian judgments (i.e., number-based and presentations to individuals with lower sensitivity resulting in more deontological judgments (i.e., rules-based. Our results may reconcile previous conflicting reports of disgust modulation of moral judgment by modeling how individual sensitivity to disgust determines the direction and degree of this effect.

  9. Individual differences in sensitivity to reward and punishment and neural activity during reward and avoidance learning.

    Science.gov (United States)

    Kim, Sang Hee; Yoon, HeungSik; Kim, Hackjin; Hamann, Stephan

    2015-09-01

    In this functional neuroimaging study, we investigated neural activations during the process of learning to gain monetary rewards and to avoid monetary loss, and how these activations are modulated by individual differences in reward and punishment sensitivity. Healthy young volunteers performed a reinforcement learning task where they chose one of two fractal stimuli associated with monetary gain (reward trials) or avoidance of monetary loss (avoidance trials). Trait sensitivity to reward and punishment was assessed using the behavioral inhibition/activation scales (BIS/BAS). Functional neuroimaging results showed activation of the striatum during the anticipation and reception periods of reward trials. During avoidance trials, activation of the dorsal striatum and prefrontal regions was found. As expected, individual differences in reward sensitivity were positively associated with activation in the left and right ventral striatum during reward reception. Individual differences in sensitivity to punishment were negatively associated with activation in the left dorsal striatum during avoidance anticipation and also with activation in the right lateral orbitofrontal cortex during receiving monetary loss. These results suggest that learning to attain reward and learning to avoid loss are dependent on separable sets of neural regions whose activity is modulated by trait sensitivity to reward or punishment.

  10. Sensitivity and Specificity of the Montreal Cognitive Assessment Modified for Individuals Who Are Visually Impaired

    Science.gov (United States)

    Wittich, Walter; Phillips, Natalie; Nasreddine, Ziad S.; Chertkow, Howard

    2010-01-01

    Evaluating the cognitive status of individuals who are visually impaired is limited by the design of the test that is used. This article presents data on the sensitivity and specificity of the version of the Montreal Cognitive Assessment for people who are visually impaired. The original validation data were reanalyzed, excluding the five visual…

  11. Distrust As a Disease Avoidance Strategy: Individual Differences in Disgust Sensitivity Regulate Generalized Social Trust

    DEFF Research Database (Denmark)

    Aarøe, Lene; Osmundsen, Mathias; Petersen, Michael Bang

    2016-01-01

    that these motivations should prompt people to avoid others more broadly. Empirically, we utilize two convenience samples and a large nationally representative sample of US citizens to demonstrate the existence of a robust and replicable effect of individual differences in pathogen disgust sensitivity on generalized...

  12. Individual differences in disgust sensitivity modulate neural responses to aversive/disgusting stimuli.

    NARCIS (Netherlands)

    Mataix-Cols, D.; An, S.K.; Lawrence, N.S.; Caseras, X.; Speckens, A.E.M.; Giampietro, V.; Brammer, M.J.; Phillips, M.L.

    2008-01-01

    Little is known about how individual differences in trait disgust sensitivity modulate the neural responses to disgusting stimuli in the brain. Thirty-seven adult healthy volunteers completed the Disgust Scale (DS) and viewed alternating blocks of disgusting and neutral pictures from the Internation

  13. [Factors of individual radiation sensitivity in caries prevalence in population of radiation polluted regions].

    Science.gov (United States)

    Sevbitov, A V; Skatova, E A

    2005-01-01

    Analysing dental diseases prevalence in population of radiation polluted regions after the Chernobyl accident, one should take into account not only the level of the soil contamination with radionuclides but also factors of individual sensitivity to radioactivity, main of which is the age of the exposed person.

  14. Heightened Olfactory Sensitivity in Young Females with Recent-Onset Anorexia Nervosa and Recovered Individuals

    Science.gov (United States)

    Bentz, Mette; Guldberg, Johanne; Vangkilde, Signe; Pedersen, Tine; Plessen, Kerstin Jessica; Jepsen, Jens Richardt Moellegaard

    2017-01-01

    Introduction Olfaction may be related to food restriction and weight loss. However, reports regarding olfactory function in individuals with anorexia nervosa (AN) have been inconclusive. Objective Characterize olfactory sensitivity and identification in female adolescents and young adults with first-episode AN and young females recovered from AN. Methods We used the Sniffin’ Sticks Odor Threshold Test and Odor Identification Test to assess 43 participants with first-episode AN, 27 recovered participants, and 39 control participants. Participants completed the Importance of Olfaction questionnaire, the Beck Youth Inventory and the Eating Disorder Inventory. We also conducted a psychiatric diagnostic interview and the Autism Diagnostic Observation Schedule with participants. Results Both clinical groups showed heightened olfactory sensitivity. After excluding participants with depression, participants with first-episode AN identified more odors than recovered participants. Conclusion Heightened olfactory sensitivity in AN may be independent of clinical status, whereas only individuals with current AN and without depression show more accurate odor identification. PMID:28060877

  15. Hyper-accreting black hole as GRB central engine. I: Baryon loading in GRB jets

    CERN Document Server

    Lei, Wei-Hua; Liang, En-Wei

    2012-01-01

    A hyper-accreting stellar-mass black hole has been long speculated as the best candidate of central engine of gamma-ray bursts (GRBs). Recent rich observations of GRBs by space missions such as Swift and Fermi pose new constraints on GRB central engine models. In this paper, we study the baryon loading processes of a GRB jet launched from a black hole central engine. We consider a relativistic jet powered by $\

  16. Delay discounting, risk-taking, and rejection sensitivity among individuals with Internet and Video Gaming Disorders

    Science.gov (United States)

    Weinstein, Aviv; Abu, Hodaya Ben; Timor, Ayelet; Mama, Yaniv

    2016-01-01

    Background and aims There is a previous evidence for impulsivity in individuals with Internet and Video Gaming Disorders. The aim of this study was to examine whether Internet and video game addictions are associated with experiential delay discounting, risk-taking, and sensitivity to social rejection using computerized tasks and questionnaires. Methods Twenty participants (mean age 24, SD = 1.55) with high score on the Problematic Online Gaming Questionnaire (POGQ) were compared with 20 participants (mean age 24.8, SD = 1.34) with low score on the POGQ. They performed on computerized Balloon Analog Risk Task and Experiential Delay discounting Task (EDT), and filled in the sensitivity to social rejection questionnaire. Results Participants with high POGQ scores had lower measures of delay discounting, higher measures of risk-taking, and higher measures of sensitivity to social rejection compared with participants with low POGQ scores. Discussion The results of this study support the previous evidence of risk-taking and provide new evidence for difficulties in delay discounting and sensitivity to social rejection among those who score high on Internet and video games. Conclusions The results suggest that Internet- and video game-addicted individuals seek immediate gratification and cannot wait for later reward. Furthermore, these individuals spend time in the virtual world, where they feel safe, and avoid social interactions presumably due to fears of social rejection. PMID:27958761

  17. The host of GRB 060206: kinematics of a distant galaxy

    CERN Document Server

    Thoene, Christina C; Ledoux, Cedric; Starling, Rhaana L C; Fynbo, Johan P U; Curran, Peter A; Gorosabel, Javier; van der Horst, Alexander J; Kewley, Lisa J; Levan, Andrew J; LLorente, Alvaro; Rol, Evert; Tanvir, Nial R; Postigo, Antonio de Ugarte; Vreeswijk, Paul M; Wijers, Ralph A M J

    2007-01-01

    Context. The spectra of afterglows can provide us with detailed information on the line-of-sight towards high redshift gamma-ray bursts (GRBs). This allows us to use GRB afterglows as sensitive probes of interstellar matter in their host galaxies, and the circumstellar material around the progenitor star. Aims. In this paper we present early WHT/ISIS optical spectroscopy of the afterglow of the gamma-ray burst GRB 060206 at z = 4.048, detecting a range of metal absorption lines and their fine-structure transitions. Additional information is provided by properties derived from the afterglow lightcurve and from deep imaging of the host galaxy. Methods. The resolution and wavelength range of the spectra and the bright afterglow facilitate a detailed study of the circumburst and host galaxy environment through fitting of the absorption line systems. Their column densities allow us to derive properties for the different detected velocity components. We also use the deep imaging to detect the host galaxy and probe ...

  18. GRB Probes of the Early Universe with EXIST

    CERN Document Server

    Grindlay, Jonathan E

    2010-01-01

    With the Swift detection of GRB090423 at z = 8.2, it was confirmed that GRBs are now detectable at (significantly) larger redshifts than AGN, and so can indeed be used as probes of the Early Universe. The proposed Energetic X-ray Imaging Survey Telescope (EXIST) mission has been designed to detect and promptly measure redshifts and both soft X-ray (0.1 - 10 keV) and simultaneous nUV-nIR (0.3 - 2.3microns) imaging and spectra for GRBs out to redshifts z ~18, which encompasses (or even exceeds) current estimates for Pop III stars that are expected to be massive and possibly GRB sources. Scaling from Swift for the ~10X greater sensitivity of EXIST, more than 100 GRBs at z >=8 may be detected and would provide direct constraints on the formation and evolution of the first stars and galaxies. For GRBs at redshifts z >= 8, with Lyman breaks at greater than 1.12microns, spectra at resolution R = 30 or R = 3000 for afterglows with AB magnitudes brighter than 24 or 20 (respectively) within ~3000sec of trigger will dir...

  19. Swift and optical observations of GRB 050401

    CERN Document Server

    De Pasquale, M; Barthelmy, S D; Boyd, P; Burrows, D N; Fink, R; Geherls, N; Kobayashi, S; Mason, K O; McNought, R; Nousek, J A; Page, K L; Palmer, D M; Peterson, B A; Price, P A; Rich, J; Roming, P; Rosen, S R; Sakamoto, T; Schimdt, B P; Tüller, J; Wells, A A; Zane, S; Zhang, B; Ziaeepour, H; Pasquale, Massimiliano De; Beardmore, Andy P.

    2006-01-01

    We present the results of the analysis of gamma-ray and X-ray data of GRB 050401 taken with the Swift satellite, together with a series of ground-based follow-up observations. The Swift X-ray light curve shows a clear break at about 4900 seconds after the GRB. The decay indices before and after the break are consistent with a scenario of continuous injection of radiation from the 'central engine' of the GRB to the fireball. Alternatively, this behaviour could result if ejecta are released with a range of Lorentz factors with the slower shells catching up the faster at the afterglow shock position. The two scenarios are observationally indistinguishable. The GRB 050401 afterglow is quite bright in the X-ray band but weak in the optical, with an optical to X-ray flux ratio similar to those of 'dark bursts'. We detect a significant amount of absorption in the X-ray spectrum, with N_H = (1.7 +/- 0.2) x 10^22 cm^-2 at a redshift of z=2.9, which is typical of a dense circumbust medium. Such high column density impl...

  20. GRB070610 : A Curious Galactic Transient

    CERN Document Server

    Kasliwal, M M; Kulkarni, S R; Cameron, P B; Nakar, E; Ofek, E O; Rau, A; Soderberg, A M; Campana, S; Bloom, J S; Perley, D A; Pollack, L; Barthelmy, S; Cummings, J; Gehrels, N; Krimm, H A; Markwardt, C B; Sato, G; Chandra, P; Frail, D; Fox, D B; Price, P; Berger, E; Grebenev, S A; Krivonos, R A; Sunyaev, R A

    2007-01-01

    GRB070610 is a typical high-energy event with a duration of 5s. Yet within the burst localization we detect a highly unusual X-ray and optical transient, Swift J195509.6+261406. We see high amplitude X-ray and optical variability on very short time scales even at late times. Using near-infrared imaging assisted by a laser guide star and adaptive optics, we have identified a quiescent counterpart to Swift J195509.6+261406. Our spectroscopic observations show that the spectral type of the counterpart is likely a K dwarf/sub-giant. It is possible that GRB070610 and Swift J195509.6+261406 are unrelated sources. However, the absence of a typical X-ray afterglow from GRB070610 in conjunction with the spatial and temporal coincidence of GRB070610 and Swift J195509.6+261406 motivate us to suggest that the sources are related. The closest analog to Swift J195509.6+261406 is V4641 Sgr, an unusual black hole binary. We suggest that Swift J195509.6+261406 along with V4641 Sgr define a sub-class of stellar black holes -- ...

  1. Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats.

    Science.gov (United States)

    Kim, Sun Kwang; Min, Byung-Il; Kim, Ji Hoon; Hwang, Byung Gil; Yoo, Gi Yong; Park, Dong Suk; Na, Heung Sik

    2005-10-31

    In neuropathic rats sensitive to phentolamine (alpha-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (alpha1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the alpha-adrenoreceptor subtype predominantly involved in cold allodynia.

  2. Study of tactile sensitivity by Semmes–Weinstein monofilaments in patients with carpal tunnel syndrome and healthy individuals

    Directory of Open Access Journals (Sweden)

    I. G. Mikhailyuk

    2014-01-01

    Full Text Available Surface sensitivity disorders are observed in many diseases of the central and peripheral nervous system. Surface sensitivity thresholds were estimated in healthy individuals and patients with carpal tunnel syndrome. There was a statistically significant (p < 0.001 increase in the sensitivity threshold in the distal phalanx of the index finger in patients with carpal tunnel syndrome as compared to healthy individuals, by evaluating the surface sensitivity by Semmes–Weinstein monofilaments.

  3. Is GRB 050904 at z=6.3 absorbed by dust?

    CERN Document Server

    Stratta, G; Maiolino, R

    2011-01-01

    Claim of dust extinction for this GRB has been debated in the past. We suggest that the discrepant results occur primarily because most of previous studies have not simultaneously investigated the X-ray to near-IR spectral energy distribution of this GRB. The difficulty with this burst is that the X-ray afterglow is dominated by strong flares at early times and is poorly monitored at late times. In addition, the Z band photometry, which is the most sensitive to dust extinction, has been found to be affected by strong systematics. In this paper we carefully re-analyze the Swift/XRT afterglow observations of this GRB, using extensive past studies of X-ray flare properties when computing the X-ray afterglow flux level and exploiting the recent reanalysis of the optical (UV rest frame) data of the same GRB. We extract the X-ray to optical/near-IR afterglow SED for the three epochs where the best spectral coverage is available: 0.47, 1.25, and 3.4 days after the trigger. A spectral power-law model has been fitted ...

  4. Is there a genetic contribution to cultural differences? Collectivism, individualism and genetic markers of social sensitivity.

    Science.gov (United States)

    Way, Baldwin M; Lieberman, Matthew D

    2010-06-01

    Genes and culture are often thought of as opposite ends of the nature-nurture spectrum, but here we examine possible interactions. Genetic association studies suggest that variation within the genes of central neurotransmitter systems, particularly the serotonin (5-HTTLPR, MAOA-uVNTR) and opioid (OPRM1 A118G), are associated with individual differences in social sensitivity, which reflects the degree of emotional responsivity to social events and experiences. Here, we review recent work that has demonstrated a robust cross-national correlation between the relative frequency of variants in these genes and the relative degree of individualism-collectivism in each population, suggesting that collectivism may have developed and persisted in populations with a high proportion of putative social sensitivity alleles because it was more compatible with such groups. Consistent with this notion, there was a correlation between the relative proportion of these alleles and lifetime prevalence of major depression across nations. The relationship between allele frequency and depression was partially mediated by individualism-collectivism, suggesting that reduced levels of depression in populations with a high proportion of social sensitivity alleles is due to greater collectivism. These results indicate that genetic variation may interact with ecological and social factors to influence psychocultural differences.

  5. The long rapid decay phase of the extended emission from the short GRB 080503

    CERN Document Server

    Genet, Franck; Granot, Jonathan

    2009-01-01

    GRB080503 was classified as a short GRB with extended emission (Perley et al. 2009). The origin of such extended emission (found in about a quarter of Swift short GRBs) is still unclear and may provide some clues to the identity of the elusive progenitors of short GRBs. The extended emission from GRB 080503 is followed by a rapid decay phase (RDP) that is detected over an unusually large dynamical range (one decade in time and ~3.5 decades in flux). We model the broad envelope of extended emission and the subsequent RDP using a physical model (Genet & Granot 2009), in which the prompt emission (and its tail) is the sum of its individual pulses (and their tails). For GRB 080503, a single pulse fit is found to be unacceptable. The RDP displays very strong spectral evolution and shows some evidence for the presence of two spectral components with different temporal behaviour, likely arising from distinct physical regions. A two pulse fit provides a much better fit to the data. The shallow gamma-ray and steep...

  6. GRB afterglows: Dust extinction properties from the low to high redshift universe

    Science.gov (United States)

    Zafar, Tayyaba

    2016-11-01

    Long-duration Gamma-ray bursts (GRBs) are excellent probes to study dust extinction due to their occurrence in star-forming regions and having simple synchrotron emission spectra. Inclusion of spectroscopic data to the GRB X-ray to the infrared spectral energy distribution (SED) could better define the continuum and confirm extinction feature. A preliminary SED analysis of GRB afterglows targeted with the VLT/X-Shooter spectrograph finds that all the 60% of extinguished bursts fit-well with featureless extinction curves. The longer wavelength coverage from ultraviolet to the near-infrared of X-Shooter helps to derive individual extinction curves and determine the total-to-selective extinction, RV precisely, suggesting extinction curves steeper (with a mean of RV = 2.66 ± 0.10) than the Small Magellanic Cloud. Moreover, addition of more data to the study of dust-to-metals ratios in GRB afterglows, quasar absorbers, and multiply lensed galaxies still shows the dust-to-metals ratios close to the Galactic value (with a mean value of log - 21.2cm-2mag-1), hinting short time delay between metals and dust formation. Such studies demonstrate the strength of using GRB afterglows to study dust origin and its properties the from low to high redshift Universe.

  7. "Anomalous" Optical GRB Afterglows are Common: Two z~4 Bursts, GRB 060206 and 060210

    CERN Document Server

    Stanek, K Z; Calkins, M L; Dai, X; Dobrzycki, A; Garnavich, P M; Hao, H; Howk, C; Matheson, T; Prieto, J L; Serven, J; Worthey, G

    2006-01-01

    We report on two recent z~4 gamma-ray bursts (GRBs), GRB 060206 and GRB 060210, for which we have obtained well-sampled optical light curves. Our data, combined with early optical data reported in the literature, shows unusual behavior for both afterglows. In R-band GRB 060206 (z=4.045) experienced a slow early decay, followed by a rapid increase in brightness by factor ~2.5 about 1 hour after the burst. Its afterglow then faded in a broken power-law fashion, with a smooth break at t_b=0.6 days, but with additional, less dramatic (~10%) ``bumps and wiggles'', well detected in the densely sampled light curve. The R-band afterglow of GRB 060210 (z=3.91) is also unusual: the light curves was more or less flat between 60 and 300 sec after the burst, followed by ~70% increase at ~600 sec after the burst, after which the light curve declined as a \\~t^{-1.3} power-law. The early X-ray light curve of GRB 060210 exhibited two sharp flares, but later X-ray emission fades in the same fashion as the optical light curve. ...

  8. The weak INTEGRAL bursts GRB040223 and GRB040624: an emerging population of dark afterglows

    CERN Document Server

    Filliatre, P; D'Avanzo, P; De Luca, A; Gotz, D; McGlynn, S; McBreen, S; Fugazza, D; Antonelli, A; Campana, S; Chincarini, G; Cucchiara, A; Valle, M D; Foley, S; Goldoni, P; Hanlon, L; Israel, G; McBreen, B; Mereghetti, S; Stella, L; Tagliaferri, G

    2005-01-01

    We report here gamma-ray, X-ray and near-infrared observations of GRB040223 along with gamma-ray and optical observations of GRB040624. GRB040223 was detected by INTEGRAL close to the Galactic plane and GRB040624 at high Galactic latitude. Analyses of the prompt emission detected by the IBIS instrument on INTEGRAL are presented for both bursts. The two GRBs have long durations, slow pulses and are weak. The gamma-ray spectra of both bursts are best fit with steep power-laws, implying they are X-ray rich. GRB040223 is among the weakest and longest of INTEGRAL GRBs. The X-ray afterglow of this burst was detected 10 hours after the prompt event by XMM-Newton. The measured spectral properties are consistent with a column density much higher than that expected from the Galaxy, indicating strong intrinsic absorption. We carried out near-infrared observations 17 hours after the burst with the NTT of ESO, which yielded upper limits. Given the intrinsic absorption, we find that these limits are compatible with a simpl...

  9. Evidence of polarisation in the prompt gamma-ray emission from GRB 930131 and GRB 960924

    CERN Document Server

    Willis, D R; Bird, A J; Clark, D J; Dean, A J; McConnell, M L; Moran, L; Shaw, S E; Sguera, V

    2005-01-01

    The true nature of the progenitor to GRBs remains elusive; one characteristic that would constrain our understanding of the GRB mechanism considerably is gamma-ray polarimetry measurements of the initial burst flux. We present a method that interprets the prompt GRB flux as it Compton scatters off the Earth's atmosphere, based on detailed modelling of both the Earth's atmosphere and the orbiting detectors. The BATSE mission aboard the \\textit{CGRO} monitored the whole sky in the 20 keV - 1 MeV energy band continuously from April 1991 until June 2000. We present the BATSE Albedo Polarimetry System (BAPS), and show that GRB 930131 and GRB 960924 provide evidence of polarisation in their prompt flux that is consistent with degrees of polarisation of $\\Pi>35$% and $\\Pi>50$% respectively. While the evidence of polarisation is strong, the method is unable to strongly constrain the degree of polarisation beyond a systematics based estimation. Hence the implications on GRB theory are unclear, and further measurements...

  10. Evidence for TeV Emission from GRB 970417a

    CERN Document Server

    Atkins, R; Berley, D; Chen, M L; Coyne, D G; Dingus, B L; Dorfan, D E; Ellsworth, R W; Evans, D; Falcone, A D; Fleysher, L; Fleysher, R; Gisler, G; Goodman, J A; Haines, T J; Hoffman, C M; Hugenberger, S; Kelley, L A; Leonor, I; McConnell, M; McCullough, J F; McEnery, J E; Miller, R S; Mincer, A I; Morales, M F; Némethy, P; Ryan, J M; Shen, B; Shoup, A L; Sinnis, C; Smith, A J; Sullivan, G W; Tümer, T O; Wang, K; Wascko, M O; Westerhoff, S; Williams, D A; Yang, T; Yodh, G B

    2000-01-01

    Milagrito, a detector sensitive to very high energy gamma rays, monitored the northern sky from February 1997 through May 1998. With a large field of view and a high duty cycle, this instrument was well suited to perform a search for TeV gamma-ray bursts (GRBs). We report on a search made for TeV counterparts to GRBs observed by BATSE. BATSE detected 54 GRBs within the field of view of Milagrito during this period. An excess of events coincident in time and space with one of these bursts, GRB 970417a, was observed by Milagrito. The excess has a chance probability of $2.8 \\times 10^{-5}$ of being a fluctuation of the background. The probability for observing an excess at least this large from any of the 54 bursts is $1.5 \\times 10^{-3}$. No significant correlations were detected from the other bursts.

  11. The bright optical flash from GRB 060117

    CERN Document Server

    Jel'inek, M; Kubánek, P; Hudec, R; Nekola, M; Grygar, J; Castro-Tirado, A J; Gorosabel, J; Hrabovsk'y, M; Mandat, D; Nosek, D; Palatka, M; Pandey, S B; Pech, M; Schovanek, P; De Postigo, A U; Vítek, S; Jel\\'inek, Martin; Prouza, Michael; Kub\\'anek, Petr; Hudec, Ren\\'e; Nekola, Martin; R}\\'idk\\'y, Jan {; Grygar, Ji{r}\\'i; Castro-Tirado, Alberto J.; Gorosabel, Javier; Hrabovsk\\'y, Miroslav; Mand\\'at, Du{s}an; Nosek, Dalibor; Palatka, Miroslav; Pandey, Shashi B.; Pech, Miroslav; Schov\\'anek, Petr; S}m\\'ida, Radom\\'ir {; Postigo, Antonio de Ugarte; V\\'itek, Stanislav

    2006-01-01

    We present a discovery and observation of an extraordinarily bright prompt optical emission of the GRB 060117 obtained by a wide-field camera atop the robotic telescope FRAM of the Pierre Auger Observatory from 2 to 10 minutes after the GRB. We found rapid average temporal flux decay of alpha = -1.7 +- 0.1 and a peak brightness R = 10.1 mag. Later observations by other instruments set a strong limit on the optical and radio transient fluxes, unveiling an unexpectedly rapid further decay. We present an interpretation featuring a relatively steep electron-distribution parameter p ~ 3.0 and providing a straightforward solution for the overall fast decay of this optical transient as a transition between reverse and forward shock.

  12. Spinal Manipulative Therapy Specific Changes In Pain Sensitivity In Individuals With Low Back Pain (NCT01168999)

    Science.gov (United States)

    Bialosky, Joel E; George, Steven Z; Horn, Maggie E; Price, Donald D; Staud, Roland; Robinson, Michael E

    2013-01-01

    Spinal Manipulative Therapy (SMT) is effective for some individuals experiencing low back pain (LBP); however, the mechanisms are not established regarding the role of placebo. SMT is associated with changes in pain sensitivity suggesting related altered central nervous system response or processing of afferent nociceptive input. Placebo is also associated with changes in pain sensitivity and the efficacy of SMT for changes in pain sensitivity beyond placebo has not been adequately considered. We randomly assigned 110 participants with LBP to receive SMT, placebo SMT, placebo SMT with the instructional set, “The manual therapy technique you will receive has been shown to significantly reduce low back pain in some people”, or no intervention. Participants receiving the SMT and placebo SMT received their assigned intervention 6 times over two weeks. Pain sensitivity was assessed prior to and immediately following the assigned intervention during the first session. Clinical outcomes were assessed at baseline and following two weeks of participation in the study. Immediate attenuation of suprathreshold heat response was greatest following SMT (p= 0.05, partial η2= 0.07). Group dependent differences were not observed for changes in pain intensity and disability at two week. Participant satisfaction was greatest following the enhanced placebo SMT. PMID:24361109

  13. Use of water-Cherenkov detectors to detect Gamma Ray Bursts at the Large Aperture GRB Observatory (LAGO)

    Energy Technology Data Exchange (ETDEWEB)

    Allard, D. [APC, CNRS et Universite Paris 7 (France); Allekotte, I. [Centro Atomico Bariloche, Instituto Balseiro (Argentina); Alvarez, C. [Facultad de Ciencias Fisico-Matematicas de la BUAP (Mexico); Asorey, H. [Centro Atomico Bariloche, Instituto Balseiro (Argentina); Barros, H. [Laboratorio de Fisica Nuclear, Universidad Simon Bolivar, Caracas (Venezuela, Bolivarian Republic of); Bertou, X. [Centro Atomico Bariloche, Instituto Balseiro (Argentina)], E-mail: bertou@cab.cnea.gov.ar; Burgoa, O. [Instituto de Investigaciones Fisicas, UMSA (Bolivia); Gomez Berisso, M. [Centro Atomico Bariloche, Instituto Balseiro (Argentina); Martinez, O. [Facultad de Ciencias Fisico-Matematicas de la BUAP (Mexico); Miranda Loza, P. [Instituto de Investigaciones Fisicas, UMSA (Bolivia); Murrieta, T.; Perez, G. [Facultad de Ciencias Fisico-Matematicas de la BUAP (Mexico); Rivera, H. [Instituto de Investigaciones Fisicas, UMSA (Bolivia); Rovero, A. [Instituto de Astronomia y Fisica del Espacio (Argentina); Saavedra, O. [Dipartimento di Fisica Generale and INFN, Torino (Italy); Salazar, H. [Facultad de Ciencias Fisico-Matematicas de la BUAP (Mexico); Tello, J.C. [Laboratorio de Fisica Nuclear, Universidad Simon Bolivar, Caracas (Venezuela, Bolivarian Republic of); Ticona Peralda, R.; Velarde, A. [Instituto de Investigaciones Fisicas, UMSA (Bolivia); Villasenor, L. [Facultad de Ciencias Fisico-Matematicas de la BUAP (Mexico); Instituto de Fisica y Matematicas, Universidad de Michoacan (Mexico)

    2008-09-21

    The Large Aperture GRB Observatory (LAGO) project aims at the detection of high energy photons from Gamma Ray Bursts (GRB) using the single particle technique in ground-based water-Cherenkov detectors (WCD). To reach a reasonable sensitivity, high altitude mountain sites have been selected in Mexico (Sierra Negra, 4550 m a.s.l.), Bolivia (Chacaltaya, 5300 m a.s.l.) and Venezuela (Merida, 4765 m a.s.l.). We report on detector calibration and operation at high altitude, search for bursts in 4 months of preliminary data, as well as search for signal at ground level when satellites report a burst.

  14. The Sensitivity of the Parkes Pulsar Timing Array to Individual Sources of Gravitational Waves

    CERN Document Server

    Yardley, D R B; Jenet, F A; Verbiest, J P W; Wen, Z L; Manchester, R N; Coles, W A; van Straten, W; Bailes, M; Bhat, N D R; Burke-Spolaor, S; Champion, D J; Hotan, A W; Sarkissian, J M

    2010-01-01

    We present the sensitivity of the Parkes Pulsar Timing Array to gravitational waves emitted by individual super-massive black-hole binary systems in the early phases of coalescing at the cores of merged galaxies. Our analysis includes a detailed study of the effects of fitting a pulsar timing model to non-white timing residuals. Pulsar timing is sensitive at nanoHertz frequencies and hence complementary to LIGO and LISA. We place a sky-averaged constraint on the merger rate of nearby ($z < 0.6$) black-hole binaries in the early phases of coalescence with a chirp mass of $10^{10}\\,\\rmn{M}_\\odot$ of less than one merger every seven years. The prospects for future gravitational-wave astronomy of this type with the proposed Square Kilometre Array telescope are discussed.

  15. Filaggrin mutations are strongly associated with contact sensitization in individuals with dermatitis

    DEFF Research Database (Denmark)

    Thyssen, Jacob P; Linneberg, Allan; Ross-Hansen, Katrine

    2013-01-01

    Background. Although heterozygous filaggrin gene (FLG) mutation carriers seem to have an increased risk of atopic, irritant and allergic nickel dermatitis, it remains unclear whether the risk of contact sensitization to allergens other than nickel is also elevated in FLG mutation carriers....... Objectives. We hypothesized that heterozygous FLG mutation carriers who suffer from dermatitis will have strongly reduced or even absent filaggrin levels during episodes of inflammation, potentially increasing the penetration of contact allergens, and hence the risk of becoming sensitized. Materials...... and methods. During 2006-2008, 3335 randomly invited 18-69-year-old adult Danes participated in a general health examination, filled out a questionnaire, and were genotyped for the R501X and 2282del4 mutations in FLG. Results. A logistic regression analysis restricted to individuals who reported atopic...

  16. GRB Prompt Optical Observations by Master and Lomonosov

    Science.gov (United States)

    Gorbovskoy, Evgeny

    We present the results of the prompt, early and afterglow optical observations of five γ-ray bursts (GRBs): GRB 100901A, GRB 100902A, GRB 100905A, GRB 100906A and GRB 101020A. These observations were made with the Mobile Astronomical System of TElescope-Robots in Russia (MASTER-II Net), the 1.5-m telescope of the Sierra Nevada Observatory and the 2.56-m Nordic Optical Telescope. For two sources, GRB 100901A and GRB 100906A, we detected optical counterparts and obtained light curves starting before the cessation of γ-ray emission, at 113 and 48 s after the trigger, respectively. Observations of GRB 100906A were conducted in two polarizing filters. Observations of the other three bursts gave the upper limits on the optical flux; their properties are briefly discussed. A more detailed analysis of GRB 100901A and GRB 100906A, supplemented by Swift data, provides the following results and indicates different origins for the prompt optical radiation in the two bursts. The light-curve patterns and spectral distributions suggest that there is a common production site for the prompt optical and high-energy emission in GRB 100901A. The results of the spectral fits for GRB 100901A in the range from optical to X-ray favour power-law energy distributions and a consistent value of the optical extinction in the host galaxy. GRB 100906A produced a smoothly peaking optical light curve, suggesting that the prompt optical radiation in this GRB originated in a front shock. This is supported by a spectral analysis. We have found that the Amati and Ghirlanda relations are satisfied for GRB 100906A. We obtain an upper limit on the value of the optical extinction on the host of GRB 100906A. Also we consider prompt observation of dark gamma ray bursts for which on very widefield cameras MASTER-VWF and MASTER-II telescopes upper limits were received. We represent SHOCK experiment onboard the spacecraft Lomonosov.

  17. Constraining the energy budget of GRB 080721

    NARCIS (Netherlands)

    Starling, R.L.C.; Rol, E.; van der Horst, A.J.; Yoon, S.C.; Pal'shin, V.; Ledoux, C.; Page, K.L.; Fynbo, J.P.U.; Wiersema, K.; Tanvir, N.R.; Jakobsson, P.; Guidorzi, C.; Curran, P.A.; Levan, A.J.; O'Brien, P.T.; Osborne, J.P.; Svinkin, D.; de Ugarte Postigo, A.; Oosting, T.; Howarth, I.D.

    2009-01-01

    We follow the bright, highly energetic afterglow of Swift-discovered GRB 080721 at z = 2.591 out to 36 d or 3 x 10(6) s since the trigger in the optical and X-ray bands. We do not detect a break in the late-time light curve inferring a limit on the opening angle of theta(j) >= 7 degrees.3 and settin

  18. SYNCHROTRON ORIGIN OF THE TYPICAL GRB BAND FUNCTION—A CASE STUDY OF GRB 130606B

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Bin-Bin; Briggs, Michael S. [Center for Space Plasma and Aeronomic Research (CSPAR), University of Alabama in Huntsville, Huntsville, AL 35899 (United States); Uhm, Z. Lucas; Zhang, Bing [Department of Physics and Astronomy, University of Nevada, Las Vegas, NV 89154 (United States); Connaughton, Valerie, E-mail: binbin.zhang@uah.edu [Science and Technology Institute, Universities Space Research Association, Huntsville, AL 35805 (United States)

    2016-01-10

    We perform a time-resolved spectral analysis of GRB 130606B within the framework of a fast-cooling synchrotron radiation model with magnetic field strength in the emission region decaying with time, as proposed by Uhm and Zhang. The data from all time intervals can be successfully fit by the model. The same data can be equally well fit by the empirical Band function with typical parameter values. Our results, which involve only minimal physical assumptions, offer one natural solution to the origin of the observed GRB spectra and imply that, at least some, if not all, Band-like GRB spectra with typical Band parameter values can indeed be explained by synchrotron radiation.

  19. Assessment of retinal sensitivity using a time-saving strategy in normal individuals

    Directory of Open Access Journals (Sweden)

    Suzumura H

    2012-11-01

    Full Text Available Hirotaka Suzumura,1 Keiji Yoshikawa,2 Shiro Mizoue,3 Ryoko Hyodo,4 Tairo Kimura5 1Eye Department, Nakano General Hospital, Tokyo, 2Yoshikawa Eye Clinic, Tokyo, 3Department of Ophthalmology, Ehime University, Ehime, 4Eye Department, Minami Matsuyama Hospital, Ehime, 5Ueno Eye Clinic, Tokyo, JapanBackground: The purpose of this study was to compare retinal sensitivities in normal individuals obtained using the Swedish Interactive Threshold Algorithm Standard (SITA-S on the Humphrey field analyzer with those obtained using the Dynamic strategy on the Octopus.Methods: Prior to visual field examinations, the background luminance, stimulus size, and exposure time with the Octopus 101 were conformed to the Humphrey field analyzer II settings. Volunteers over 20 years of age without apparent ophthalmic abnormalities were examined with the SITA-S central 30-2 program followed by the Dynamic 32 program. Eye with corrected visual acuity ≥0.8, refraction ≥ −6.0 diopters, and fields with satisfactory levels of reliability in SITA-S and Dynamic were selected.Results: Sixty-seven eyes from 67 normal individuals of mean age 51.3 ± 16.3 (range 22–76 years satisfied the selection criteria and were analyzed. Mean retinal sensitivity was significantly (P < 0.0001 higher with SITA-S (29.0 ± 2.4 dB than with Dynamic (26.8 ± 2.1 dB. Changes in retinal sensitivity with increasing age were significantly (P = 0.0003 greater with Dynamic (−0.09 ± 0.04 dB/year; 95% confidence interval [CI] −0.10 to −0.08 dB/year than with SITA-S (−0.07 ± 0.04 dB/year, 95% CI −0.08 to −0.06 dB/year. When classifying the visual field into three areas (central, mid-peripheral, and peripheral, retinal sensitivities with SITA-S were significantly higher in all areas than with Dynamic (P < 0.0001 for all three areas.Conclusion: Differences in Dynamic and SITA-S strategies may contribute to the differences in retinal sensitivities observed in normal individuals

  20. Constraining GRB progenitors environment with Swift XRT

    CERN Document Server

    Saez, Dounia

    2015-01-01

    The characteristics of the Gamma-Ray Bursts (GRBs) environment may reflect the differences in GRB progenitors: long GRBs are expected to be found in high-density star-forming regions of the GRB host galaxies, while short ones may be associated with an older stellar population that may have had the time to travel far from stellar forming regions in potentially lower density regions. The latter is related to the hypothesis that short GRBs are associated to the merging of compact objects (BH-NS or NS-NS). We used the Swift XRT GRB afterglow archive to compare the intrinsic neutral hydrogen column density values for long and short GRBs within the redshift range 0.1- 1.3, performing a coherent analysis, and excluding from our analysis observations with poor statistics, which reduced our sample to 15 short GRBs. While short GRBs effectively show a median absorption value smaller than long ones the result is not statistically significant. In order to increase our sample we added short GRBs without redshift measure, ...

  1. Ultra-sensitive flow measurement in individual nanopores through pressure--driven particle translocation.

    Science.gov (United States)

    Gadaleta, Alessandro; Biance, Anne-Laure; Siria, Alessandro; Bocquet, Lyderic

    2015-05-07

    A challenge for the development of nanofluidics is to develop new instrumentation tools, able to probe the extremely small mass transport across individual nanochannels. Such tools are a prerequisite for the fundamental exploration of the breakdown of continuum transport in nanometric confinement. In this letter, we propose a novel method for the measurement of the hydrodynamic permeability of nanometric pores, by diverting the classical technique of Coulter counting to characterize a pressure-driven flow across an individual nanopore. Both the analysis of the translocation rate, as well as the detailed statistics of the dwell time of nanoparticles flowing across a single nanopore, allow us to evaluate the permeability of the system. We reach a sensitivity for the water flow down to a few femtoliters per second, which is more than two orders of magnitude better than state-of-the-art alternative methods.

  2. Neural correlates of individual differences in anxiety sensitivity: an fMRI study using semantic priming.

    Science.gov (United States)

    Yang, Yunbo; Lueken, Ulrike; Wittmann, André; Holtz, Katharina; Kleint, Nina Isabel; Herrmann, Martin J; Sass, Katharina; Jansen, Andreas; Konrad, Carsten; Ströhle, Andreas; Pfleiderer, Bettina; Lotze, Martin; Hamm, Alfons; Deckert, Jürgen; Arolt, Volker; Wittchen, Hans-Ulrich; Kircher, Tilo; Straube, Benjamin

    2016-08-01

    Individuals with high anxiety sensitivity (AS) have an increased risk of developing anxiety disorders and are more biased in how they process fear-related stimuli. This study investigates the neural correlates of fear-related words and word associations in high- and low-AS individuals. We used a semantic priming paradigm during functional magnetic resonance imaging in which three types of target words (fear symptoms, e.g. 'dizziness'; neutral, e.g. 'drink'; and pseudowords, e.g. 'salkom') were preceded by two types of prime words (fear-triggers, e.g. 'elevator'; and neutral, e.g. 'bottle'). Subjects with high AS rated fear-symptom words (vs neutral words) as more unpleasant than low-AS individuals; they also related these words more strongly to fear-triggers and showed prolonged reaction times. During the processing of fear-symptom words, greater activation in the left anterior insula was observed in high-AS subjects than in low-AS subjects. Lower activation in the left inferior frontal gyrus, angular gyrus, fusiform gyrus and bilateral amygdalae was found in high-AS subjects when fear-symptom words were preceded by fear-trigger words. The findings suggest that cognitive biases and the anterior insula play a crucial role in high-AS individuals. Furthermore, semantic processes may contribute to high AS and the risk of developing anxiety disorders. © The Author (2016). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  3. An individual reproduction model sensitive to milk yield and body condition in Holstein dairy cows.

    Science.gov (United States)

    Brun-Lafleur, L; Cutullic, E; Faverdin, P; Delaby, L; Disenhaus, C

    2013-08-01

    To simulate the consequences of management in dairy herds, the use of individual-based herd models is very useful and has become common. Reproduction is a key driver of milk production and herd dynamics, whose influence has been magnified by the decrease in reproductive performance over the last decades. Moreover, feeding management influences milk yield (MY) and body reserves, which in turn influence reproductive performance. Therefore, our objective was to build an up-to-date animal reproduction model sensitive to both MY and body condition score (BCS). A dynamic and stochastic individual reproduction model was built mainly from data of a single recent long-term experiment. This model covers the whole reproductive process and is composed of a succession of discrete stochastic events, mainly calving, ovulations, conception and embryonic loss. Each reproductive step is sensitive to MY or BCS levels or changes. The model takes into account recent evolutions of reproductive performance, particularly concerning calving-to-first ovulation interval, cyclicity (normal cycle length, prevalence of prolonged luteal phase), oestrus expression and pregnancy (conception, early and late embryonic loss). A sensitivity analysis of the model to MY and BCS at calving was performed. The simulated performance was compared with observed data from the database used to build the model and from the bibliography to validate the model. Despite comprising a whole series of reproductive steps, the model made it possible to simulate realistic global reproduction outputs. It was able to well simulate the overall reproductive performance observed in farms in terms of both success rate (recalving rate) and reproduction delays (calving interval). This model has the purpose to be integrated in herd simulation models to usefully test the impact of management strategies on herd reproductive performance, and thus on calving patterns and culling rates.

  4. A New GRB follow-up Software at TUG

    Science.gov (United States)

    Dindar, M.; Parmaksizoglu, M.; Helhel, S.; Esenoglu, H.; Kirbiyik, H.

    2016-12-01

    A gamma-ray burst (GRB) optical photometric follow-up system at TUBITAK (Scientic and Technological Research Council of Turkey) National Observatory (TUG) has been planned. It uses the 0.6 m Telescope (T60) and can automatically respond to GRB Coordinates Network (GCN) alerts. The telescopes slew relatively fast, being able to point to a new target field within 30 s upon a request. Whenever available, the 1 m T100 and 2.5 m RTT150 telescopes will be used in the future. As an example in 2015, the GRB software system (will be server side) at T60-telescope responded to GRB alert and started the observation as early as 129 s after the GRB trigger autonomously.

  5. Trajectories of glycaemia, insulin sensitivity and insulin secretion in South Asian and white individuals before diagnosis of type 2 diabetes

    DEFF Research Database (Denmark)

    Hulman, Adam; Simmons, Rebecca K; Brunner, Eric J

    2017-01-01

    PG trajectories. CONCLUSIONS/INTERPRETATION: We observed different trajectories of plasma glucose, insulin sensitivity and secretion prior to diabetes diagnosis in South Asian and white individuals. This might be due to ethnic differences in the natural history of diabetes. South Asian individuals experienced......AIMS/HYPOTHESIS: South Asian individuals have reduced insulin sensitivity and increased risk of type 2 diabetes compared with white individuals. Temporal changes in glycaemic traits during middle age suggest that impaired insulin secretion is a particular feature of diabetes development among South...... (FPG), 2 h post-load plasma glucose (2hPG), fasting serum insulin (FSI), 2 h post-load serum insulin (2hSI), HOMA of insulin sensitivity (HOMA2-S) and secretion (HOMA2-B), and the Gutt insulin sensitivity index (ISI0,120) among 120 South Asian and 867 white participants who developed diabetes during...

  6. Alterations in Diets of Patients With Nonceliac Gluten Sensitivity Compared With Healthy Individuals.

    Science.gov (United States)

    Zingone, Fabiana; Bartalini, Chiara; Siniscalchi, Monica; Ruotolo, Monica; Bucci, Cristina; Morra, Ivonne; Iovino, Paola; Ciacci, Carolina

    2017-01-01

    There is evidence that food components beyond gluten cause symptoms in patients with gluten sensitivity without celiac disease (nonceliac gluten sensitivity [NCGS]). We investigated the diets and nutritional characteristics of patients with NCGS. We performed a prospective observational study of 29 patients with NCGS seen at the outpatient clinic for celiac disease and other food intolerances of the University of Salerno in Italy from September 2015 through April 2016. Our study also included 37 control subjects. An experienced dietitian administered a validated food frequency questionnaire (from the European Prospective Investigation into Cancer and Nutrition) to collect information on amounts of common foods consumed. Patients and control subjects also completed the Eating Attitudes Test for diet-related disorders. Patients with NCGS completed the Minnesota Multiphasic Personality Inventory 2-I questionnaire. Differences in frequencies between patients and control subjects were calculated using chi-square test, whereas differences between continuous variables were calculated using Student t test. All tests were 2-tailed with significance level set at P 65 from the Minnesota Multiphasic Personality Inventory, indicating a high level of concern for their health. In an observational study, we found that patients with NCGS eat different foods than healthy individuals; patients consume lower levels of proteins, carbohydrates, fiber, and polyunsaturated fatty acids. Their diets should be routinely analyzed and possibly corrected to avoid nutritional deficiencies. Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

  7. Is a low content in atranol/chloroatranol safe in oak moss-sensitized individuals?

    Science.gov (United States)

    Nardelli, Andrea; Giménez-Arnau, Elena; Bernard, Guillaume; Lepoittevin, Jean-Pierre; Goossens, An

    2009-02-01

    Chloroatranol and atranol are degradation products of chloroatranorin and atranorin, respectively, and have been identified as important contact allergens in oak moss absolute (Evernia prunastri). To investigate whether chemically modified extracts of oak moss produce positive patch test reactions in previously sensitized subjects. A sample of oak moss was treated by a polymer-based method to reduce the content of the two main allergens, namely atranol and chloroatranol, from 3.4% to less than 75 p.p.m. and from 1.8% to less than 25 p.p.m., respectively. Fourteen subjects with positive reactions to oak moss from Trolab and/or Chemotechnique were patch tested to this sample, diluted 1% in petrolatum. The chemically modified sample reacted negatively in six but gave still positive reactions in eight subjects, with the same intensity as the commercially available oak moss patch test materials. Polymer-based treatment of oak moss extract reduces the allergenic elicitation potential in previously sensitized individuals only to a minor extent. The residual concentrations of atranol and chloroatranol being less than 75 p.p.m. and 25 p.p.m., respectively, are unsafe for the consumer.

  8. Template Reproduction of GRB Pulse Light Curves

    Science.gov (United States)

    Hakkila, Jon E.; Preece, R. D.; Loredo, T. J.; Wolpert, R. L.; Broadbent, M. E.

    2014-01-01

    A study of well-isolated pulses in gamma ray burst light curves indicates that simple models having smooth and monotonic pulse rises and decays are inadequate. Departures from the Norris et al. (2005) pulse shape are in the form of a wave-like pre-peak residual that is mirrored and stretched following the peak. Pulse shape departures are present in GRB pulses of all durations, but placement of the departures relative to pulse peaks correlates with asymmetry. This establishes an additional link between temporal structure and spectral evolution, as pulse asymmetry is related to initial hardness while pulse duration indicates the rate of hard-to-soft pulse evolution.

  9. The Structure and Dynamics of GRB Jets

    Energy Technology Data Exchange (ETDEWEB)

    Granot, Jonathan; /KIPAC, Menlo Park

    2006-10-25

    There are several lines of evidence which suggest that the relativistic outflows in gamma-ray bursts (GRBs) are collimated into narrow jets. The jet structure has important implications for the true energy release and the event rate of GRBs, and can constrain the mechanism responsible for the acceleration and collimation of the jet. Nevertheless, the jet structure and its dynamics as it sweeps up the external medium and decelerates, are not well understood. In this review I discuss our current understanding of GRB jets, stressing their structure and dynamics.

  10. The host galaxy of GRB 990712

    DEFF Research Database (Denmark)

    Christensen, L.; Hjorth, J.; Gorosabel, J.

    2004-01-01

    We present a comprehensive study of the z = 0.43 host galaxy of GRB 990712, involving ground-based photometry, spectroscopy, and HST imaging. The broad-band UBVRIJHKs photometry is used to determine the global spectral energy distribution (SED) of the host galaxy. Comparison with that of known...... galaxy types shows that the host is similar to a moderately kreddened starburst galaxy with a young stellar population. The estimated internal extinction in the host is A(V) = 0.15 +/- 0.1 and the star-formation rate (SFR) from the UV continuum is 1.3 +/- 0.3 M-circle dot yr(-1) (not corrected...... for the effects of extinction). Other galaxy template spectra than starbursts failed to reproduce the observed SED. We also present VLT spectra leading to the detection of Halpha from the GRB host galaxy. A SFR of 2.8 +/- 0.7 M-circle dot yr(-1) is inferred from the Halpha line flux, and the presence of a young...

  11. The Observable Signatures of GRB Cocoons

    CERN Document Server

    Nakar, Ehud

    2016-01-01

    As a long GRB jet propagates within the surrounding stellar atmosphere it creates a cocoon composed of an outer Newtonian shocked stellar material and an inner (possibly relativistic) shocked jet material. The jet deposits $10^{51}-10^{52}$ erg into this cocoon. This energy is comparable to the GRB's energy and to the energy of the accompanying supernova, yet its signature has been largely neglected so far. A fraction of the cocoon energy is released during its expansion following the breakout from the star and later as it interacts with the surrounding matter. We explore here the possible signatures of the cocoon emission and outline a framework to calculate them from the conditions of the cocoon at the time of the jet breakout. We show that the cocoon signature depends strongly on the level of mixing between the shocked jet and shocked stellar material that fills it, which is currently unknown. We find that if there is no mixing at all then the $\\gamma$-ray emission from the cocoon is so bright that it shou...

  12. GRB 080319b and SN1054 .

    Science.gov (United States)

    Martocchia, A.; Polcaro, V. F.

    A typical SN Type IIp model can fit the SN1054 explosion light curve when data coming from European sources are also considered. Though a detailed study of these texts reveals a number of problems in their precise datation, it is likely that they actually describe the observation of an unusual celestial event which occurred in a day near to the one of Pope Leo IX's death (19 April, 1054). In particular, they seem to show that a very bright transient celestial phenomenon, lasting about 30 min, was observed. We already suggested that this Medieval testimonies were due to a very short and bright light flash in the first phase of the SN precursor collapse. The discovery of a similar flash in GRB 080319b brought us to consider this hypothesis more deeply. We thus scaled the intensity of the GRB 080319b to a distance of 1.83 kpc, in order to evaluate the intensity of a similar flash in the SN1054. We then took this value as input of the atmospheric optical effects simulation code \\textit{HaloSim3}, using the point-like source option for the dates and sites reported in European texts connected with the SN1054 event, and in various atmospheric conditions. The results are remarkably similar to the effects reported in Medieval chronicles.

  13. The Optical Afterglow of GRB 011211

    CERN Document Server

    Holland, S T; Gladders, M D; Barrientos, L F; Berlind, P; Bersier, D F; Garnavich, P M; Jha, S; Stanek, K Z; Holland, Stephen T.; Gladders, Michael D.; Bersier, David; Garnavich, Peter M.; Jha, Saurabh

    2002-01-01

    We present early-time optical photometry and spectroscopy of the optical afterglow of the gamma-ray burst GRB 011211. The spectrum contains several narrow metal lines which are consistent with the burst occurring at a redshift of 2.140 +/- 0.001. The optical afterglow decays as a power law with a slope of 0.83 +/- 0.04 for approximately the first two days after the burst at which time there is evidence for a break. The slope after the break is greater than approximately 1.4. There is evidence for rapid variations in the R-band light approximately 0.5 days after the burst, which suggests that there are density fluctuations near the GRB on spatial scales of approximately 30 to 200 AU. The magnitude of the break in the light curve, and the observed fluence, suggest that the burst expanded into an ambient medium that is homogeneous on large scales with a local particle density between approximately 0.1 and 10 per cubic cm. The total energy in the burst was 1.6-2.4 x 10^50 erg, consistent with the ``standard'' val...

  14. GRB Catalog: Bursts from Vela to Swift

    Science.gov (United States)

    Angelini, L.

    2008-01-01

    Gamma ray burst (GRB) astronomy started when the first event was recorded on July 2, 1967 by Vela 4a and 4b. Since then many missions have flown experiments capable of detecting GRBs. The events collected by these older experiments are mostly available in paper copy, each containing a few ten to a few hundred bursts. No systematic effort in cataloging of these bursts has been available. In some cases the information is unpublished and in others difficult to retrieve. The first major GRB catalog was obtained by GRO with the BATSE experiment. It contains more than 2000 bursts and includes homogeneous information for each of the bursts. With the launch of Swift, the first Gamma-ray/X-ray mission dedicated to the study of GRBs and their afterglows, a wealth of information is collected by the Swift instrument as well as from ground-based telescopes. This talk will describe the efforts to create a comprehensive GRBCAT and its current status and future prospective.

  15. A multi band study of the optically dark GRB 051028

    CERN Document Server

    Urata, Yuji; Kuo, Ping-Hung; Ip, Wing-Huen; Qiu, Yulei; Masuno, Keisuke; Tashiro, Makoto; Abe, Keichi; Onda, Kaori; Kodaka, Natsuki; Kuwahara, Makoto; Tamagawa, Toru; Usui, Fumihiko; Ioka, Kunihito; Lee, Yi-Hsi; Wei, Jianyan; Deng, Jinsong; Zheng, Weikang; Makishima, Kazuo

    2007-01-01

    Observations were made of the optical afterglow of GRB 051028 with the Lulin observatory's 1.0 m telescope and the WIDGET robotic telescope system. R band photometric data points were obtained on 2005 October 28 (UT), or 0.095-0.180 days after the burst. There is a possible plateau in the optical light curve around 0.1 days after the burst; the light curve resembles optically bright afterglows (e.g. GRB 041006, GRB 050319, GRB060605) in shape of the light curve but not in brightness. The brightness of the GRB 051028 afterglow is 3 magnitudes fainter than that of one of the dark events, GRB 020124. Optically dark GRBs have been attributed to dust extinction within the host galaxy or high redshift. However, the spectrum analysis of the X-rays implies that there is no significant absorption by the host galaxy. Furthermore, according to the model theoretical calculation of the Ly$\\alpha$ absorption to find the limit of GRB 051028's redshift, the expected $R$ band absorption is not high enough to explain the darkn...

  16. Alcohol induces sensitization to gluten in genetically susceptible individuals: a case control study.

    Directory of Open Access Journals (Sweden)

    Stuart Currie

    Full Text Available BACKGROUND: The mechanisms of cerebellar degeneration attributed to prolonged and excessive alcohol intake remain unclear. Additional or even alternative causes of cerebellar degeneration are often overlooked in suspected cases of alcohol-related ataxia. The objectives of this study were two fold: (1 to investigate the prevalence of gluten-related serological markers in patients with alcohol-related ataxia and; (2 to compare the pattern of brain involvement on magnetic resonance imaging between patients with alcohol and gluten ataxias. MATERIALS & METHODS: Patients diagnosed with alcohol and gluten ataxias were identified from a retrospective review of patients attending a tertiary clinic. HLA genotype and serological markers of gluten-related disorders were recorded. Cerebellar volumetry, MR spectroscopy and voxel-based morphometric analyses were performed on patients and compared with matched control data. RESULTS: Of 904 registered patients, 104 had alcohol ataxia and 159 had gluten ataxia. 61% of the alcohol ataxia group and 70% of the gluten ataxia group had HLA DQ2/DQ8 genotype compared to 30% in healthy local blood donors. 44% of patients with alcohol ataxia had antigliadin antibodies compared to 12% in the healthy local population and 10% in patients with genetically confirmed ataxias. None of the patients with alcohol ataxia and antigliadin antibodies had celiac disease compared to 40% in patients with gluten ataxia. The pattern of structural brain abnormality in patients with alcohol ataxia who had antigliadin antibodies differed from gluten ataxia and was identical to that of alcohol ataxia. CONCLUSIONS: Alcohol related cerebellar degeneration may, in genetically susceptible individuals, induce sensitization to gluten. Such sensitization may result from a primary cerebellar insult, but a more systemic effect is also possible. The duration and amount of exposure to alcohol may not be the only factors responsible for the cerebellar

  17. Correlation between the adaptive response and individual sensitivity to monoepoxybutene in in vitro experiments on human lymphocytes.

    Science.gov (United States)

    Sasiadek, M; Paprocka-Borowicz, M

    1997-05-23

    Individual variations in the susceptibility to mutagenic/carcinogenic chemicals depend on the activity of xenobiotic metabolizing enzymes and on DNA- and chromosome-damage repair systems. Monoepoxybutene (MEB) is a genotoxic metabolite of 1,3-butadiene (BD), which has been classified as a probable carcinogen in humans. The purpose of the present study was to investigate by in vitro experiments on human whole blood lymphocytes (WBL), whether an individual sensitivity to MEB correlates with the adaptive response to the tested agent. In the analyzed group, 8.3% of blood donors were relatively sensitive to MEB. The comparison of SCE induction in cultures pretreated and not pretreated with an adaptive dose (AD) of MEB showed, that there was an adaptive response to MEB. The adaptive response in the group of relatively sensitive donors was similar to that of the relatively resistant ones. This result suggests that individual sensitivity to the tested agent and adaptive response depend on different biological mechanisms.

  18. H.E.S.S. Observations of the Prompt and Afterglow Phases of GRB 060602B

    CERN Document Server

    Aharonian, F; Barresde Almeida, U; Bazer-Bachi, A R; Behera, B; Beilicke, M; Benbow, W; Bernlöhr, K; Boisson, C; Borrel, V; Braun, I; Brion, E; Brucker, J; Buhler, R; Bulik, T; Büsching, I; Boutelier, T; Carrigan, S; Chadwick, P M; Chaves, R; Chounet, L M; Clapson, A C; Coignet, G; Cornils, R; Costamante, L; Dalton, M; Degrange, B; Dickinson, H J; Djannati-Atai, A; Domainko, W; O'Connor-Drury, L; Dubois, F; Dubus, G; Dyks, J; Egberts, K; Emmanoulopoulos, D; Espigat, P; Farnier, C; Feinstein, F; Fiasson, A; Förster, A; Fontaine, G; Fussling, M; Gabici, S; Gallant, Y A; Giebels, B; Glicenstein, J F; Glück, B; Goret, P; Hadjichristidis, C; Hauser, D; Hauser, M; Heinzelmann, G; Henri, G; Hermann, G; Hinton, J A; Hoffmann, A; Hofmann, W; Holleran, M; Hoppe, S; Horns, D; Jacholkowska, A; De Jager, O C; Jung, I; Katarzy, K; Kendziorra, E; Kerschhaggl, M; Khangulyan, D; Kh, B; Keogh, D; Komin, Nu; Kosack, K; Lamanna, G; Latham, I J; Lenain, J P; Lohse, T; Martin, J M; Martineau-Huynh, O; Marcowith, A; Masterson, C; Maurin, D; McComb, T J L; Moderski, R; Moulin, E; Naumann-Godo, M; De Naurois, Mathieu; Nedbal, D; Nekrassov, D; Nolan, S J; Ohm, S; Olive, J P; De Ona Wilhelmi, E; Orford, K J; Osborne, J L; Ostrowski, M; Panter, M; Pedaletti, G; Pelletier, G; Petrucci, P O; Pita, S; Pühlhofer, G; Punch, M; Quirrenbach, Andreas G; Raubenheimer, B C; Raue, M; Rayner, S M; Renaud, M; Rieger, F; Ripken, J; Rob, L; Rosier-Lees, S; Rowell, G; Rudak, B; Ruppel, J; Sahakian, V V; Santangelo, A; Schlickeiser, R; Sch, F M; Schroder, R; Schwanke, U; Schwarzburg, S; Schwemmer, S; Shalchi, A; Sol, H; Spangler, D; Stawarz, L; Steenkamp, R; Stegmann, C; Superina, G; Tam, P H; Tavernet, J P; Terrier, R; Van Eldik, C; Vasileiadis, G; Venter, C; Vialle, J P; Vincent, P; Vivier, M; Völk, H J; Volpe, F; Wagner, S J; Ward, M; Zdziarski, A A; Zech, A

    2008-01-01

    We report on the first completely simultaneous observation of a gamma-ray burst (GRB) using an array of Imaging Atmospheric Cherenkov Telescopes which is sensitive to photons in the very-high-energy (VHE) gamma-ray range (>~100 GeV). On 2006 June 2, the Swift Burst Alert Telescope (BAT) registered an unusually soft gamma-ray burst (GRB 060602B). The burst position was under observation using the High Energy Stereoscopic System (H.E.S.S.) at the time the burst occurred. Data were taken before, during, and after the burst. A total of 5 hours of observations were obtained during the night of 2006 June 2-3, and 5 additional hours were obtained over the next 3 nights. No VHE gamma-ray signal was found during the period covered by the H.E.S.S. observations. The 99% confidence level flux upper limit (>1 TeV) for the prompt phase (9s) of GRB 060602B is 2.9x10^-9 erg cm^-2 s^-1. Due to the very soft BAT spectrum of the burst compared to other Swift GRBs and its proximity to the Galactic center, the burst is likely ass...

  19. Observational constraints on the afterglow of GRB 020531

    CERN Document Server

    Klotz, A H; Atteia, J L; Klotz, Alain; Boer, Michel; Atteia, Jean-Luc

    2003-01-01

    We present the data acquired by the TAROT automated observatory on the afterglow of GRB 020531. Up to now, no convincing afterglow emission has been reported for this short/hard GRB at any wavelength, including X-ray and optical. The combination of our early limits, with other published data allows us to put severe constraints on the afterglow magnitude and light curve. The limiting magnitude is 18.5 in R band, 88 minutes after the GRB, and the decay slope power law index could be larger than 2.2.

  20. GRB as a counterpart for Gravitational Wave detection in LCGT

    Science.gov (United States)

    Kanda, Nobuyuki

    2010-10-01

    Short Gamma-ray burst (GRB) progenitors are considered as merger of compact star binaries which consist of neutron stars or blackholes. These compact star binaries will radiate a strong gravitational wave in their coalescence, and gravitational wave detectors aim to detect them. We studied the chance probability of coincidence between GRB and GW detection in LCGT detector. Due to omni-directional acceptance of GW detectors, about 75% of GRB events which closer than cosmological redshift z<0.1 are expected to confirm by GW detection.

  1. Individual differences in attributional style but not in interoceptive sensitivity, predict subjective estimates of action intention.

    Directory of Open Access Journals (Sweden)

    Tegan ePenton

    2014-08-01

    Full Text Available The debate on the existence of free will is on-going. Seminal findings by Libet et al. demonstrate that subjective awareness of a voluntary urge to act (the W-judgement occurs before action execution. Libet’s paradigm requires participants to perform voluntary actions while watching a clock hand rotate. On response trials, participants make a retrospective judgement related to awareness of their urge to act. This research investigates the relationship between individual differences in performance on the Libet task and self-awareness. We examined the relationship between W-judgement, Attributional Style (AS; a measure of perceived control and interoceptive sensitivity (IS; awareness of stimuli originating from one’s body; e.g. heartbeats. Thirty participants completed the AS questionnaire (ASQ, a heartbeat estimation task (IS, and the Libet paradigm. The ASQ score significantly predicted performance on the Libet task, while IS did not - more negative ASQ scores indicated larger latency between W-judgement and action execution. A significant correlation was also observed between ASQ score and IS. This is the first research to report a relationship between W-judgement and AS and should inform the future use of electroencephalography to investigate the relationship between AS, W-judgement and RP onset. Our findings raise questions surrounding the importance of one’s perceived control in determining the point of conscious intention to act. Furthermore, we demonstrate possible negative implications associated with a longer period between conscious awareness and action execution.

  2. A Search for Gravitational Waves Associated with the Gamma Ray Burst GRB030329 Using the LIGO Detectors

    CERN Document Server

    Abbott, R; Ageev, A; Allen, B; Amin, R; Anderson, S B; Anderson, W G; Araya, M; Armandula, H; Ashley, M; Asiri, F; Aufmuth, P; Aulbert, C; Babak, S; Balasubramanian, R; Ballmer, S; Barish, B C; Barker, C; Barker, D; Barnes, M; Barr, B; Barton, M A; Bayer, K; Beausoleil, R; Belczynski, K; Bennett, R; Berukoff, S J; Betzwieser, J; Bhawal, B; Bilenko, I A; Billingsley, G; Black, E; Blackburn, K; Blackburn, L; Bland, B; Bochner, B; Bogue, L; Bork, R; Bose, S; Brady, P R; Braginsky, V B; Brau, J E; Brown, D A; Bullington, A; Bunkowski, A; Buonanno, A; Burgess, R; Busby, D; Butler, W E; Byer, R L; Cadonati, L; Cagnoli, G; Camp, J B; Cantley, C A; Cardenas, L; Carter, K; Casey, M M; Castiglione, J; Chandler, A; Chapsky, J; Charlton, P; Chatterji, S; Chelkowski, S; Chen, Y; Chickarmane, V; Chin, D; Christensen, N; Churches, D; Cokelaer, T; Colacino, C; Coldwell, R; Coles, M; Cook, D; Corbitt, T; Coyne, D; Creighton, J D E; Creighton, T D; Crooks, D R M; Csatorday, P; Cusack, B J; Cutler, C; D'Ambrosio, E; Danzmann, K; Daw, E; De Bra, D; Delker, T; Dergachev, V; DeSalvo, R; Dhurandhar, S V; Di Credico, A; Díaz, M; Ding, H; Drever, R W P; Dupuis, R J; Edlund, J A; Ehrens, P; Elliffe, E J; Etzel, T; Evans, M; Evans, T; Fairhurst, S; Fallnich, C; Farnham, D; Fejer, M M; Findley, T; Fine, M; Finn, L S; Franzen, K Y; Freise, A; Frey, R; Fritschel, P; Frolov, V V; Fyffe, M; Ganezer, K S; Garofoli, J; Giaime, J A; Gillespie, A; Goda, K; González, G; Goler, S; Grandclément, P; Grant, A; Gray, C; Gretarsson, A M; Grimmett, D; Grote, H; Grünewald, S; Günther, M; Gustafson, E; Gustafson, R; Hamilton, W O; Hammond, M; Hanson, J; Hardham, C; Harms, J; Harry, G; Hartunian, A; Heefner, J; Hefetz, Y; Heinzel, G; Heng, I S; Hennessy, M; Hepler, N; Heptonstall, A; Heurs, M; Hewitson, M; Hild, S; Hindman, N; Hoang, P; Hough, J; Hrynevych, M; Hua, W; Ito, M; Itoh, Y; Ivanov, A; Jennrich, O; Johnson, B; Johnson, W W; Johnston, W R; Jones, D I; Jones, L; Jungwirth, D; Kalogera, V; Katsavounidis, E; Kawabe, K; Kawamura, S; Kells, W; Kern, J; Khan, A; Killbourn, S; Killow, C J; Kim, C; King, C; King, P; Klimenko, S; Koranda, S; Kotter, K; Kovalik, Yu; Kozak, D; Krishnan, B; Landry, M; Langdale, J; Lantz, B; Lawrence, R; Lazzarini, A; Lei, M; Leonor, I; Libbrecht, K; Libson, A; Lindquist, P; Liu, S; Logan, J; Lormand, M; Lubinski, M; Luck, H; Lyons, T T; Machenschalk, B; MacInnis, M; Mageswaran, M; Mailand, K; Majid, W; Malec, M; Mann, F; Marin, A; Marka, S; Maros, E; Mason, J; Mason, K; Matherny, O; Matone, L; Mavalvala, N; McCarthy, R; McClelland, D E; McHugh, M; McNabb, J W C; Mendell, G; Mercer, R A; Meshkov, S; Messaritaki, E; Messenger, C; Mitrofanov, V P; Mitselmakher, G; Mittleman, R; Miyakawa, O; Miyoki, S; Mohanty, S; Moreno, G; Mossavi, K; Müller, G; Mukherjee, S; Murray, P; Myers, J; Nagano, S; Nash, T; Nayak, R; Newton, G; Nocera, F; Noel, J S; Nutzman, P; Olson, T; O'Reilly, B; Ottaway, D J; Ottewill, A; Ouimette, D A; Overmier, H; Owen, B J; Pan, Y; Papa, M A; Parameshwaraiah, V; Parameswariah, C; Pedraza, M; Penn, S; Pitkin, M; Plissi, M; Prix, R; Quetschke, V; Raab, F; Radkins, H; Rahkola, R; Rakhmanov, M; Rao, S R; Rawlins, K; Ray-Majumder, S; Re, V; Redding, D; Regehr, M W; Regimbau, T; Reid, S; Reilly, K T; Reithmaier, K; Reitze, D H; Richman, S; Riesen, R; Riles, K; Rivera, B; Rizzi, A; Robertson, D I; Robertson, N A; Robison, L; Roddy, S; Rollins, J; Romano, J D; Romie, J; Rong, H; Rose, D; Rotthoff, E; Rowan, S; Rüdiger, A; Russell, P; Ryan, K; Salzman, I; Sandberg, V; Sanders, G H; Sannibale, V; Sathyaprakash, B; Saulson, P R; Savage, R; Sazonov, A; Schilling, R; Schlaufman, K; Schmidt, V; Schnabel, R; Schofield, R; Schutz, B F; Schwinberg, P; Scott, S M; Seader, S E; Searle, A C; Sears, B; Seel, S; Seifert, F; Sengupta, A S; Shapiro, C A; Shawhan, P; Shoemaker, D H; Shu, Q Z; Sibley, A; Siemens, X; Sievers, L; Sigg, D; Sintes, A M; Smith, J R; Smith, M; Smith, M R; Sneddon, P H; Spero, R; Stapfer, G; Steussy, D; Strain, K A; Strom, D; Stuver, A; Summerscales, T; Sumner, M C; Sutton, P J; Sylvestre, J; Takamori, A; Tanner, D B; Tariq, H; Taylor, I; Taylor, R; Thorne, K A; Thorne, K S; Tibbits, M; Tilav, S; Tinto, M; Tokmakov, K V; Torres, C; Torrie, C; Traylor, G; Tyler, W; Ugolini, D W; Ungarelli, C; Vallisneri, M; Van Putten, M H P M; Vass, S; Vecchio, A; Veitch, J; Vorvick, C; Vyachanin, S P; Wallace, L; Walther, H; Ward, H; Ware, B; Watts, K; Webber, D; Weidner, A; Weiland, U; Weinstein, A; Weiss, R; Welling, H; Wen, L; Wen, S; Whelan, J T; Whitcomb, S E; Whiting, B F; Wiley, S; Wilkinson, C; Willems, P A; Williams, P R; Williams, R; Willke, B; Wilson, A; Winjum, B J; Winkler, W; Wise, S; Wiseman, A G; Woan, G; Wooley, R; Worden, J; Wu, W; Yakushin, I; Yamamoto, H; Yoshida, S; Zaleski, K D; Zanolin, M; Zawischa, I; Zhang, L; Zhu, R; Zotov, N P; Zucker, M; Zweizig, J

    2005-01-01

    We have performed a search for bursts of gravitational waves associated with the very bright Gamma Ray Burst GRB030329, using the two detectors at the LIGO Hanford Observatory. Our search covered the most sensitive frequency range of the LIGO detectors (approximately 80-2048 Hz), and we specifically targeted signals shorter than 150 ms. Our search algorithm looks for excess correlated power between the two interferometers and thus makes minimal assumptions about the gravitational waveform. We observed no candidates with gravitational wave signal strength larger than a pre-determined threshold. We report frequency dependent upper limits on the strength of the gravitational waves associated with GRB030329. Near the most sensitive frequency region, around 250 Hz, our root-sum-square (RSS) gravitational wave strain sensitivity for optimally polarized bursts was better than h_RSS = 6E-21 Hz^{-1/2}. Our result is comparable to the best published results searching for association between gravitational waves and GRBs...

  3. Study of GRB Light-curve Decay Indices in the Afterglow Phase

    Science.gov (United States)

    Del Vecchio, Roberta; Dainotti, Maria Giovanna; Ostrowski, Michał

    2016-09-01

    In this work, we study the distribution of temporal power-law decay indices, α, in the gamma-ray burst (GRB) afterglow phase, fitted for 176 GRBs (139 long GRBs, 12 short GRBs with extended emission, and 25 X-ray flashes) with known redshifts. These indices are compared with the temporal decay index, α W , derived with the light-curve fitting using the Willingale et al. model. This model fitting yields similar distributions of α W to the fitted α, but for individual bursts a difference can be significant. Analysis of (α, L a ) distribution, where L a is the characteristic luminosity at the end of the plateau, reveals only a weak correlation of these quantities. However, we discovered a significant regular trend when studying GRB α values along the Dainotti et al. correlation between L a and the end time of the plateau emission in the rest frame, {T}a* , hereafter LT correlation. We note a systematic variation of the α parameter distribution with luminosity for any selected {T}a* . We analyze this systematics with respect to the fitted LT correlation line, expecting that the presented trend may allow us to constrain the GRB physical models. We also attempted to use the derived correlation of α ({T}a) versus {L}a({T}a) to diminish the luminosity scatter related to the variations of α along the LT distribution, a step forward in the effort of standardizing GRBs. A proposed toy model accounting for this systematics applied to the analyzed GRB distribution results in a slight increase of the LT correlation coefficient.

  4. GRB 090227B: a First Example of a Genuine Short GRB

    Science.gov (United States)

    Muccino, M.; Bianco, C. L.; Izzo, L.; Penacchioni, A. V.; Ruffini, R.

    In the context of the Fireshell scenario Gamma-Ray Bursts (GRBs) find a natural explanation in the values of three main parameters: the energy of the emitting e± plasma Etote±, the baryon load B, and the density of the Circum-Burst Medium (CBM) nCBM. For B≲10-5, the GRB consists of a spike-like emission without any afterglow: a genuine short burst. GRB 090227B is the first recognized genuine short GRB. Its analysis reveals that the transparency emission is not a pure thermal process, owing to a non-gradual transition between the optically thick and the optically thin phases. Within our theory we have recovered the original thermal spectrum of the e± plasma, namely the effective Black body (BB); we indeed have determined the parameters of the Fireshell model, including the redshift. Setting a baryon load B = 10-6, we obtain the effective temperature k{T} = (719.3±48.5) keV, the Lorentz factor at transparency Γ = 12852, and the total energy Etote± = (1.13±0.12)×1054 erg. The estimated redshift is z = 4.07±0.36.

  5. GRB Flares: A New Detection Algorithm, Previously Undetected Flares, and Implications on GRB Physics

    CERN Document Server

    Swenson, C A

    2013-01-01

    Flares in GRB light curves have been observed since shortly after the discovery of the first GRB afterglow. However, it was not until the launch of the Swift satellite that it was realized how common flares are, appearing in nearly 50% of all X-ray afterglows as observed by the XRT instrument. The majority of these observed X-ray flares are easily distinguishable by eye and have been measured to have up to as much fluence as the original prompt emission. Through studying large numbers of these X-ray flares it has been determined that they likely result from a distinct emission source different than that powering the GRB afterglow. These findings could be confirmed if similar results were found using flares in other energy ranges. However, until now, the UVOT instrument on Swift seemed to have observed far fewer flares in the UV/optical than were seen in the X-ray. This was primarily due to poor sampling and data being spread across multiple filters, but a new optimal co-addition and normalization of the UVOT ...

  6. LCD panel characterization by measuring full Jones matrix of individual pixels using polarization-sensitive digital holographic microscopy.

    Science.gov (United States)

    Park, Jongchan; Yu, Hyeonseung; Park, Jung-Hoon; Park, YongKeun

    2014-10-06

    We present measurements of the full Jones matrix of individual pixels in a liquid-crystal display (LCD) panel. Employing a polarization-sensitive digital holographic microscopy based on Mach-Zehnder interferometry, the complex amplitudes of the light passing through individual LCD pixels are precisely measured with respect to orthogonal bases of polarization states, from which the full Jones matrix components of individual pixels are obtained. We also measure the changes in the Jones matrix of individual LCD pixels with respect to an applied bias. In addition, the complex optical responses of a LCD panel with respect to arbitrary polarization states of incident light were characterized from the measured Jones matrix.

  7. Confronting GRB prompt emission with a model for subphotospheric dissipation

    CERN Document Server

    Ahlgren, Björn; Nymark, Tanja; Ryde, Felix; Pe'er, Asaf

    2015-01-01

    The origin of the prompt emission in gamma-ray bursts (GRBs) is still an unsolved problem and several different mechanisms have been suggested. Here we fit Fermi GRB data with a photospheric emission model which includes dissipation of the jet kinetic energy below the photosphere. The resulting spectra are dominated by Comptonization and contain no significant contribution from synchrotron radiation. In order to fit to the data we span a physically motivated part of the model's parameter space and create DREAM ($\\textit{Dissipation with Radiative Emission as A table Model}$), a table model for ${\\scriptsize XSPEC}$. We show that this model can describe different kinds of GRB spectra, including GRB 090618, representing a typical Band function spectrum, and GRB 100724B, illustrating a double peaked spectrum, previously fitted with a Band+blackbody model, suggesting they originate from a similar scenario. We suggest that the main difference between these two types of bursts is the optical depth at the dissipatio...

  8. RAPTOR observations of the early optical afterglow from GRB 050319

    CERN Document Server

    Wozniak, P R; Wren, J A; White, R R; Evans, S M; Casperson, D

    2005-01-01

    The RAPid Telescopes for Optical Response (RAPTOR) system at Los Alamos National Laboratory observed GRB 050319 starting 25.4 seconds after gamma-ray emission triggered the Burst Alert Telescope (BAT) on-board the Swift satellite. Our well sampled light curve of the early optical afterglow is composed of 32 points (derived from 70 exposures) that measure the flux decay during the first hour after the GRB. The GRB 050319 light curve measured by RAPTOR can be described as a relatively gradual flux decline (power-law index alpha = -0.37) with a transition, at about 400 s after the GRB, to a faster flux decay (alpha = -0.91). The addition of other available measurements to the RAPTOR light curve suggests that another emission component emerged after 10^4 s. We hypothesize that the early afterglow emission is powered by extended energy injection or delayed reverse shock emission followed by the emergence of forward shock emission.

  9. High Energy Polarimetry of Prompt GRB Emission

    CERN Document Server

    McConnell, Mark L

    2016-01-01

    Evidence of polarized $\\gamma$-ray emission ($>$ 50 keV) from Gamma-Ray Bursts (GRBs) has been accumulated in recent years. Measurements have been reported with levels in the range of 30-80\\%, typically with limited statistical significance. No clear picture has yet emerged with regards to the polarization properties of GRBs. Taken at face value, the data suggest that most GRBs have a relatively large level of polarization (typically, $> 50\\%$), which may suggest synchrotron emission associated with an ordered magnetic field structure within the GRB jet. But these results are far from conclusive. Here, we review the observations that have been made, concentrating especially on the instrumental issues and the lessons that might be learned from these data.

  10. The Spectroscopic Variability of GRB 021004

    CERN Document Server

    Matheson, T; Foltz, C; West, S; Williams, G; Falco, E E; Calkins, M L; Castander, F J; Gawiser, E; Jha, S; Bersier, D F; Stanek, K Z

    2003-01-01

    We present spectra of the optical transient (OT) associated with GRB 021004. The spectra show a blue continuum with superposed absorption features and one emission line. There are two intervening metal-line systems at z = 1.380 and z = 1.602 and one very strong absorption system at a redshift of z = 2.323. Ly_alpha emission is also seen at this redshift. While the spectrum of the OT overall cannot be simply described with a power law, the spectral index over the range 5500-8850 A is steep, F_nu prop nu^(-0.96 +/- 0.03). Comparison of spectra from multiple epochs shows a distinct color evolution with the OT becoming redder with time, implying a B-V increase of ~0.2-0.3 mag over the first three days. This is the first clear example of color change in an OT detected spectroscopically.

  11. Correlating prompt GRB photons with neutrinos

    CERN Document Server

    Taboada, Ignacio

    2007-01-01

    It is standard in theoretical neutrino astrophysics to use a broken power law approximation, based on the Band function, to describe the average photon flux of the prompt emission of Gamma-Ray Bursts. We will show that this approximation overestimates the contribution of high energy gamma-rays (and underestimates low energy gamma-rays). As a consequence models that rely on this approximation overestimate neutrino event rate by a factor of approx 2 depending on Earth's column density in the direction of the GRB. Furthermore the characteristic energy of neutrinos that trigger a km^3 detector is typically 10^{16} eV, higher than previously predicted. We also provide a new broken power law approximation to the Band function and show that it properly represents the photon spectra.

  12. Search for TeV Gamma-ray Emission from GRB 100621A, an extremely bright GRB in X-rays, with H.E.S.S

    CERN Document Server

    Abramowski, A; Benkhali, F Ait; Akhperjanian, A G; Angüner, E; Anton, G; Balenderan, S; Balzer, A; Barnacka, A; Becherini, Y; Tjus, J Becker; Bernlöhr, K; Birsin, E; Bissaldi, E; Biteau, J; Böttcher, M; Boisson, C; Bolmont, J; Bordas, P; Brucker, J; Brun, F; Brun, P; Bulik, T; Carrigan, S; Casanova, S; Cerruti, M; Chadwick, P M; Chalme-Calvet, R; Chaves, R C G; Cheesebrough, A; Chrétien, M; Colafrancesco, S; Cologna, G; Conrad, J; Couturier, C; Dalton, M; Daniel, M K; Davids, I D; Degrange, B; Deil, C; deWilt, P; Dickinson, H J; Djannati-Ataï, A; Domainko, W; Drury, L O'C; Dubus, G; Dutson, K; Dyks, J; Dyrda, M; Edwards, T; Egberts, K; Eger, P; Espigat, P; Farnier, C; Fegan, S; Feinstein, F; Fernandes, M V; Fernandez, D; Fiasson, A; Fontaine, G; Förster, A; Füßling, M; Gajdus, M; Gallant, Y A; Garrigoux, T; Giebels, B; Glicenstein, J F; Grondin, M -H; Grudzińska, M; Häffner, S; Hahn, J; Harris, J; Heinzelmann, G; Henri, G; Hermann, G; Hervet, O; Hillert, A; Hinton, J A; Hofmann, W; Hofverberg, P; Holler, M; Horns, D; Jacholkowska, A; Jahn, C; Jamrozy, M; Janiak, M; Jankowsky, F; Jung, I; Kastendieck, M A; Katarzyński, K; Katz, U; Kaufmann, S; Khélifi, B; Kieffer, M; Klepser, S; Klochkov, D; Kluźniak, W; Kneiske, T; Kolitzus, D; Komin, Nu; Kosack, K; Krakau, S; Krayzel, F; Krüger, P P; Laffon, H; Lamanna, G; Lefaucheur, J; Lemière, A; Lemoine-Goumard, M; Lenain, J -P; Lennarz, D; Lohse, T; Lopatin, A; Lu, C -C; Marandon, V; Marcowith, A; Marx, R; Maurin, G; Maxted, N; Mayer, M; McComb, T J L; Méhault, J; Menzler, U; Meyer, M; Moderski, R; Mohamed, M; Moulin, E; Murach, T; Naumann, C L; de Naurois, M; Niemiec, J; Nolan, S J; Oakes, L; O'Brien, P T; Ohm, S; Wilhelmi, E de Oña; Opitz, B; Ostrowski, M; Oya, I; Panter, M; Parsons, R D; Arribas, M Paz; Pekeur, N W; Pelletier, G; Perez, J; Petrucci, P -O; Peyaud, B; Pita, S; Poon, H; Pühlhofer, G; Punch, M; Quirrenbach, A; Raab, S; Raue, M; Reimer, A; Reimer, O; Renaud, M; Reyes, R de los; Rieger, F; Rob, L; Romoli, C; Rosier-Lees, S; Rowell, G; Rudak, B; Rulten, C B; Sahakian, V; Sanchez, D A; Santangelo, A; Schlickeiser, R; Schüssler, F; Schulz, A; Schwanke, U; Schwarzburg, S; Schwemmer, S; Sol, H; Spengler, G; Spies, F; Stawarz, Ł; Steenkamp, R; Stegmann, C; Stinzing, F; Stycz, K; Sushch, I; Szostek, A; Tam, P H T; Tavernet, J -P; Tavernier, T; Taylor, A M; Terrier, R; Tluczykont, M; Trichard, C; Valerius, K; van Eldik, C; Vasileiadis, G; Venter, C; Viana, A; Vincent, P; Völk, H J; Volpe, F; Vorster, M; Wagner, S J; Wagner, P; Ward, M; Weidinger, M; Weitzel, Q; White, R; Wierzcholska, A; Willmann, P; Wörnlein, A; Wouters, D; Zacharias, M; Zajczyk, A; Zdziarski, A A; Zech, A; Zechlin, H -S

    2014-01-01

    The long gamma-ray burst (GRB) 100621A, at the time the brightest X-ray transient ever detected by Swift-XRT in the $0.3\\textrm{--}10$ keV range, has been observed with the H.E.S.S. imaging air Cherenkov telescope array, sensitive to gamma radiation in the very-high-energy (VHE, $>100$ GeV) regime. Due to its relatively small redshift of $z\\sim0.5$, the favourable position in the southern sky and the relatively short follow-up time ($<700 \\rm{s}$ after the satellite trigger) of the H.E.S.S. observations, this GRB could be within the sensitivity reach of the H.E.S.S. instrument. The analysis of the H.E.S.S. data shows no indication of emission and yields an integral flux upper limit above $\\sim$380 GeV of $4.2\\times10^{-12} \\rm cm^{-2}s^{-1}$ (95 % confidence level), assuming a simple Band function extension model. A comparison to a spectral-temporal model, normalised to the prompt flux at sub-MeV energies, constraints the existence of a temporally extended and strong additional hard power law, as has been ...

  13. Blood-injection-injury phobia and fear of spiders : Domain specific individual differences in disgust sensitivity

    NARCIS (Netherlands)

    Merckelbach, H; de Jong, Peter

    1998-01-01

    We investigated whether disgust sensitivity is associated with blood-injection-injury (BII) and spider fear. We also explored whether the relationship between disgust sensitivity and phobic fears is domain specific. Ninety-six undergraduates (all women) completed the Disgust Questionnaire (DQ) (Rozi

  14. Can individualized weight monitoring using the HeartPhone algorithm improve sensitivity for clinical deterioration of heart failure?

    LENUS (Irish Health Repository)

    Ledwidge, Mark T

    2013-04-01

    Previous studies have demonstrated poor sensitivity of guideline weight monitoring in predicting clinical deterioration of heart failure (HF). This study aimed to evaluate patterns of remotely transmitted daily weights in a high-risk HF population and also to compare guideline weight monitoring and an individualized weight monitoring algorithm.

  15. Individual differences in reward sensitivity are related to food craving and relative body weight in healthy women.

    Science.gov (United States)

    Franken, Ingmar H A; Muris, Peter

    2005-10-01

    According to the theory of J.A. Gray, a strongly reactive approach system is highly sensitive to reward or to cues that signal reward. This implies that intake driven by the rewarding properties of food should be affected by individual differences in reactivity of the approach system. The present study examined whether reward sensitivity is associated with food craving and relative body weight in a sample of female college students. Participants completed the Sensitivity to Punishment and Sensitivity to Reward Questionnaire and the trait version of the Food Craving Questionnaire and also reported their weight and height in order to compute Body Mass Index (BMI). Sensitivity to reward was significantly related to food craving and BMI. Furthermore, the correlation between reward sensitivity and BMI was not attenuated when the influence of food craving was partialled out, indicating that the relation between sensitivity to reward and BMI was not mediated by food craving. This is the first study demonstrating a relation between the personality trait of sensitivity to reward and BMI. These findings are discussed in the context of the involvement of dopaminergic reward circuitry in overeating.

  16. Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease.

    Science.gov (United States)

    Uhde, Melanie; Ajamian, Mary; Caio, Giacomo; De Giorgio, Roberto; Indart, Alyssa; Green, Peter H; Verna, Elizabeth C; Volta, Umberto; Alaedini, Armin

    2016-12-01

    Wheat gluten and related proteins can trigger an autoimmune enteropathy, known as coeliac disease, in people with genetic susceptibility. However, some individuals experience a range of symptoms in response to wheat ingestion, without the characteristic serological or histological evidence of coeliac disease. The aetiology and mechanism of these symptoms are unknown, and no biomarkers have been identified. We aimed to determine if sensitivity to wheat in the absence of coeliac disease is associated with systemic immune activation that may be linked to an enteropathy. Study participants included individuals who reported symptoms in response to wheat intake and in whom coeliac disease and wheat allergy were ruled out, patients with coeliac disease and healthy controls. Sera were analysed for markers of intestinal cell damage and systemic immune response to microbial components. Individuals with wheat sensitivity had significantly increased serum levels of soluble CD14 and lipopolysaccharide (LPS)-binding protein, as well as antibody reactivity to bacterial LPS and flagellin. Circulating levels of fatty acid-binding protein 2 (FABP2), a marker of intestinal epithelial cell damage, were significantly elevated in the affected individuals and correlated with the immune responses to microbial products. There was a significant change towards normalisation of the levels of FABP2 and immune activation markers in a subgroup of individuals with wheat sensitivity who observed a diet excluding wheat and related cereals. These findings reveal a state of systemic immune activation in conjunction with a compromised intestinal epithelium affecting a subset of individuals who experience sensitivity to wheat in the absence of coeliac disease. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  17. Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease

    Science.gov (United States)

    Uhde, Melanie; Ajamian, Mary; Caio, Giacomo; De Giorgio, Roberto; Indart, Alyssa; Green, Peter H; Verna, Elizabeth C; Volta, Umberto; Alaedini, Armin

    2016-01-01

    Objective Wheat gluten and related proteins can trigger an autoimmune enteropathy, known as coeliac disease, in people with genetic susceptibility. However, some individuals experience a range of symptoms in response to wheat ingestion, without the characteristic serological or histological evidence of coeliac disease. The aetiology and mechanism of these symptoms are unknown, and no biomarkers have been identified. We aimed to determine if sensitivity to wheat in the absence of coeliac disease is associated with systemic immune activation that may be linked to an enteropathy. Design Study participants included individuals who reported symptoms in response to wheat intake and in whom coeliac disease and wheat allergy were ruled out, patients with coeliac disease and healthy controls. Sera were analysed for markers of intestinal cell damage and systemic immune response to microbial components. Results Individuals with wheat sensitivity had significantly increased serum levels of soluble CD14 and lipopolysaccharide (LPS)-binding protein, as well as antibody reactivity to bacterial LPS and flagellin. Circulating levels of fatty acid-binding protein 2 (FABP2), a marker of intestinal epithelial cell damage, were significantly elevated in the affected individuals and correlated with the immune responses to microbial products. There was a significant change towards normalisation of the levels of FABP2 and immune activation markers in a subgroup of individuals with wheat sensitivity who observed a diet excluding wheat and related cereals. Conclusions These findings reveal a state of systemic immune activation in conjunction with a compromised intestinal epithelium affecting a subset of individuals who experience sensitivity to wheat in the absence of coeliac disease. PMID:27459152

  18. Individual differences in initial morphine sensitivity as a predictor for the development of opiate addiction in rats.

    Science.gov (United States)

    Nishida, Kevin S; Park, Thomas Y; Lee, Bong Hyo; Ursano, Robert J; Choi, Kwang H

    2016-10-15

    Individuals report a wide range of analgesia to similar doses of opiates, and not all opiate users become addicted. This suggests that there may be certain predispositions that influence one to develop opiate addiction. We investigated the relationship between the individual differences in initial morphine sensitivity and the subsequent development of opiate addiction-like behavior using a hot plate test and an intravenous morphine self-administration (MSA) paradigm in rats. Using a median split of initial morphine antinociception, animals were defined as low antinociception (LA) and high antinociception (HA) groups. Thus, the LA group represents the animals that were less sensitive to initial morphine antinociception as compared to those of the HA group. The animals were allowed to self-administer either saline or morphine (0.5mg/kg/infusion, 4hr/day) 5days per week for 3 weeks. Spontaneous locomotor activity was measured on self-administration days 10 and 15. Individual differences in initial morphine sensitivity were not correlated with the amount of morphine self-administered by the animals on day 1. In the second-week of MSA, the LA group exhibited increased morphine intake and locomotor hyperactivity as compared to those of the HA group. Therefore, certain animals that are less sensitive to initial morphine antinociception may be susceptible to developing opiate addiction. The current findings may have clinical implications for future research on the biological mechanisms of opiate addiction and preclinical medication development.

  19. Predicting Performance during Chronic Sleep Loss: Identification of Factors Sensitive to Individual Fatigue Resistance

    Science.gov (United States)

    2015-03-18

    confirmed that changes in response to sleep loss were evident, whereas significance at the individual level revealed inter-individual variability in...Repeated Measures Analyses of Variance (ANOVAs) to identify those variables which were significantly affected by chronic sleep restriction. Any...during the sleep restriction phase of the study. Psychomotor Vigilance Task (PVT). Two variables from the PVT were analyzed: number of PVT

  20. GRB 090902B: afterglow observations and implications

    CERN Document Server

    Pandey, S B; Perley, D A; Guidorzi, C; Wiersema, K; Malesani, D; Akerlof, C; Ashley, M C B; Bersier, D; Cano, Z; Gomboc, A; Ilyin, I; Jakobsson, P; Kleiser, I K W; Kobayashi, S; Kouveliotou, C; Levan, A J; McKay, T A; Melandri, A; Mottram, C J; Mundell, C G; O'Brien, P T; Phillips, A; Rex, J M; Siegel, M H; Smith, R J; Steele, I A; Stratta, G; Tanvir, N R; Weights, D; Yost, S A; Yuan, F; Zheng, W

    2010-01-01

    The optical-infrared afterglow of the LAT-detected long duration burst, GRB 090902B, has been observed by several instruments. The earliest detection by ROTSE-IIIa occurred 80 minutes after detection by the GBM instrument onboard the Fermi Gamma-Ray Space Telescope, revealing a bright afterglow and a decay slope suggestive of a reverse shock origin. Subsequent optical-IR observations followed the light curve for 6.5 days. The temporal and spectral behavior at optical-infrared frequencies is consistent with synchrotron fireball model predictions; the cooling break lies between optical and XRT frequencies ~ 1.9 days after the burst. The inferred electron energy index is $p = 1.8 \\pm 0.2$, which would however imply an X-ray decay slope flatter than observed. The XRT and LAT data have similar spectral indices and the observed steeper value of the LAT temporal index is marginally consistent with the predicted temporal decay in the radiative regime of the forward shock model. Absence of a jet break during the first...

  1. GRB 141221A: gone is the wind

    CERN Document Server

    Bardho, O; Rossi, A; Amati, L; Haislip, J; Klotz, A; Palazzi, E; Reichart, D; Trotter, A S; Boer, M

    2016-01-01

    GRB 141221A was observed from infrared to soft gamma-ray bands. Here, we investigate its properties, in light of the standard model. We find that the optical light curve of the afterglow of this burst presents an unusual steep/quick rise. The broad band spectral energy distribution taken near the maximum of the optical emission presents either a thermal component or a spectral break. In the former case, the properties of the afterglow are then very unusual, but could explain the lack of apparent jet breaks in the Swift light curves. In the latter case, the afterglow properties of this burst are more usual, and we can see in the light curves the passing through of the injection and cooling frequencies within the optical bands, not masked by a reverse shock. This model also excludes the presence of a stellar wind, challenging either the stellar progenitor properties, or the very stellar nature of the progenitor itself. In all cases, this burst may be a part of a Rosetta stone that could help to explain some of ...

  2. GRB INVESTIGATIONS BY ESA GAIA AND LOFT

    Directory of Open Access Journals (Sweden)

    René Hudec

    2013-12-01

    Full Text Available The possibility of studying GRBs with the ESA Gaia and LOFT missions is briefly addressed. The ESA Gaia satellite to be launched in November 2013 will focus on high precision astrometry of stars and all objects down to limiting magnitude 20. The satellite will also provide photometric and spectral information and hence important inputs for various branches of astrophysics, including the study of GRBs and related optical afterglows (OAs and optical transients (OTs. The strength of Gaia in GRB analyses will be the fine spectral resolution (spectro-photometry and ultra-low dispersion spectroscopy, which will allow the correct classication of related triggers. An interesting feature of Gaia BP and RP instruments will be the study of highly redshifted triggers. Similarly, the low dispersion spectroscopy provided by various plate surveys can also supply valuable data for investigations of high-energy sources. The ESA LOFT candidate mission, now in the assessment study phase, will also be able to detect and be used in the study of GRBs, with emphasis on low-energy (X-ray emission.

  3. Slope evolution of GRB correlations and cosmology

    CERN Document Server

    Dainotti, Maria Giovanna; Piedipalumbo, Ester; Capozziello, Salvatore

    2013-01-01

    Gamma -ray bursts (GRBs) observed up to redshifts $z>9.4$ can be used as possible probes to test cosmological models. Here we show how changes of the slope of the {\\it luminosity $L^*_X$ -break time $T^*_a$} correlation in GRB afterglows, hereafter the LT correlation, affect the determination of the cosmological parameters. With a simulated data set of 101 GRBs with a central value of the correlation slope that differs on the intrinsic one by a $5\\sigma$ factor, we find an overstimated value of the matter density parameter, $\\Omega_M$, compared to the value obtained with SNe Ia, while the Hubble constant, $H_0$, best fit value is still compatible in 1$\\sigma$ compared to other probes. We show that this compatibility of $H_0$ is due to the large intrinsic scatter associated with the simulated sample. Instead, if we consider a subsample of high luminous GRBs ($HighL$), we find that both the evaluation of $H_0$ and $\\Omega_M$ are not more compatible in 1$\\sigma$ and $\\Omega_M$ is underestimated by the $13\\%$. Ho...

  4. The red optical afterglow of GRB 030725

    CERN Document Server

    Pugliese, G; Gorosabel, J; Jensen, B L; Fynbo, J P U; Hjorth, J; Jorgensen, S F; Monard, B; Vinter, C

    2005-01-01

    We present a photometric study of the optical counterpart of the long-duration Gamma Ray Burst (GRB) 030725, which triggered the HETE FREGATE and WXM instruments on July 25th, 2003, and lasted more than 160s. An optical counterpart was identified at the Bronberg Observatory in South Africa about 7 hours after the burst occurred. The optical afterglow (OA) was observed between 4 and 15 days after the burst with the 1.54m Danish telescope at La Silla in the V, Rc, and Ic bands. We fit a broken power law to the data and determine a break time in the light curve between 16 hours and 4.7 days after the first detection of the burst. The decay slope is alpha1 = -0.59 +0.59/-0.44 before and alpha2 = -1.43 +/- 0.06 after the break. A bump may be present in the light curve, only significant at the 2-sigma level, 13.9 days after the main burst. The spectral slope of the OA, measured 12 days after the burst, is -2.9 +/- 0.6 , i.e. it falls in the extreme red end of the distribution of previous OA spectral slopes. Observa...

  5. A Reverse Shock in GRB 130427A

    CERN Document Server

    Laskar, T; Zauderer, B A; Margutti, R; Soderberg, A M; Chakraborti, S; Lunnan, R; Chornock, R; Chandra, P; Ray, A

    2013-01-01

    We present extensive radio and millimeter observations of the unusually bright GRB 130427A at z=0.340, spanning 0.67 to 12 days after the burst. Taken in conjunction with detailed multi-band UV, optical, NIR, and X-ray observations we find that the broad-band afterglow emission is composed of distinct reverse shock and forward shock contributions. The reverse shock emission dominates in the radio/millimeter and at 0.1 days in the UV/optical/NIR. We further find that the optical and X-ray data require a Wind circumburst environment, pointing to a massive star progenitor. Using the combined forward and reverse shock emission we find that the parameters of the burst are an isotropic kinetic energy of E_Kiso~2e53 erg, a mass loss rate of Mdot~3e-8 Msun/yr (for a wind velocity of 1,000 km/s), and a Lorentz factor at the deceleration time of Gamma(200s)~130. Due to the low density and large isotropic energy, the absence of a jet break to ~15 days places only a weak constraint on the opening angle of theta_j>2.5 deg...

  6. GRB060218: A Relativistic Supernova Shock Breakout

    CERN Document Server

    Waxman, E; Campana, S

    2007-01-01

    We show that the prompt and afterglow X-ray emission of GRB060218, as well as its early (t<=1 d) optical-UV emission, can be explained by a model in which a radiation- mediated shock propagates through a compact progenitor star into a dense wind. The prompt thermal X-ray emission is produced in this model as the mildly relativistic shock, v/c=0.85 carrying few x 10^49 erg, reaches the wind (Thomson) photosphere, where the post-shock thermal radiation is released and the shock becomes collisionless. Adopting this interpretation of the thermal X-ray emission, a subsequent X-ray afterglow is predicted, due to synchrotron emission and inverse-Compton scattering of SN UV photons by electrons accelerated in the collisionless shock. Early optical-UV emission is also predicted, due to the cooling of the outer \\delta M ~10^{-3} M_sun envelope of the star, which was heated to high temperature during shock passage. The observed X-ray afterglow and the early optical-UV emission are both consistent with those expected ...

  7. A Reverse Shock in GRB 160509A

    CERN Document Server

    Laskar, Tanmoy; Berger, Edo; Fong, Wen-fai; Margutti, Raffaella; Shivvers, Isaac; Williams, Peter K G; Kopac, Drejc; Kobayashi, Shiho; Mundell, Carole; Gomboc, Andreja; Zheng, WeiKang; Menten, Karl M; Graham, Melissa L; Filippenko, Alexei V

    2016-01-01

    We present the second multi-frequency radio detection of a reverse shock in a $\\gamma$-ray burst. By combining our extensive radio observations of the Fermi-LAT GRB 160509A at $z = 1.17$ up to $20$ days after the burst with Swift X-ray observations and ground-based optical and near-infrared data, we show that the afterglow emission comprises distinct reverse shock and forward shock contributions: the reverse shock emission dominates in the radio band at $\\lesssim10~$days, while the forward shock emission dominates in the X-ray, optical, and near-infrared bands. Through multi-wavelength modeling, we determine a circumburst density of $n_0\\approx10^{-3}~$cm$^{-3}$, supporting our previous suggestion that a low-density circumburst environment is conducive to the production of long-lasting reverse shock radiation in the radio band. We infer the presence of a large excess X-ray absorption column, $N_{\\rm H} \\approx 1.5\\times10^{22}~$cm$^{-2}$, and a high rest-frame optical extinction, $A_{\\rm V}\\approx3.4~$mag. We...

  8. A Fe K Line in GRB 970508

    Science.gov (United States)

    Protassov, R.; van Dyk, D.; Connors, A.; Kashyap, V.; Siemiginowska, A.

    2000-12-01

    We examine the x-ray spectrum of the afterglow of GRB 970508, analyzed for Fe line emission by Piro et al (1999, ApJL, 514, L73). This is a difficult and extremely important measurement: the detection of x-ray afterglows from γ -ray bursts is at best a tricky business, relying on near-real satellite time response to unpredictable events; and a great deal of luck in catching a burst bright enough for a useful spectral analysis. Detecting a clear atomic (or cyclotron) line in the generally smooth and featureless afterglow (or burst) emission not only gives one of the few very specific keys to the physics local to the emission region, but also provides clues or confirmation of its distance (via redshift). Unfortunately, neither the likelihood ratio test or the related F-statistic commonly used to detect spectral lines adhere to their nominal Chi square and F-distributions. Thus we begin by calibrating the F-statistic used in Piro et al (1999, ApJL, 514, L73) via a simulation study. The simulation study relies on a completely specified source model, i.e. we do Monte Carlo simulations with all model parameters fixed (so--called ``parametric bootstrapping''). Second, we employ the method of posterior predictive p-values to calibrate a LRT statistic while accounting for the uncertainty in the parameters of the source model. Our analysis reveals evidence for the Fe K line.

  9. GRB 050505: A high redshift burst discovered by Swift

    CERN Document Server

    Hurkett, C P; Page, K L; Rol, E; Goad, M R; O'Brien, P T; Beardmore, A; Godet, O; Burrows, D N; Tanvir, N R; Levan, A; Zhang, B; Malesani, D; Hill, J E; Kennea, J A; Chapman, R; La Parola, V; Perri, M; Romano, P; Gehrels, R S N

    2006-01-01

    We report the discovery and subsequent multi-wavelength afterglow behaviour of the high redshift (z = 4.27) Gamma Ray Burst GRB 050505. This burst is the third most distant burst, measured by spectroscopic redshift, discovered after GRB 000131 (z = 4.50) and GRB 050904 (z = 6.29). GRB 050505 is a long GRB with a multipeaked gamma-ray light curve, with a duration of T_90 = 63+/-2 s and an inferred isotropic release in gamma-rays of ~4.44 x 10^53 ergs in the 1-10^4 keV rest frame energy range. The Swift X-Ray Telescope followed the afterglow for 14 days, detecting two breaks in the light curve at 7.4(+/-1.5) ks and 58.0 (+9.9/-15.4) ks after the burst trigger. The power law decay slopes before, between and after these breaks were 0.25 (+0.16/-0.17), 1.17 (+0.08/-0.09) and 1.97 (+0.27/-0.28) respectively. The light curve can also be fit with a `smoothly broken' power law model with a break observed at ~ T+18.5 ks, with decay slopes of ~0.4 and ~1.8 before and after the break respectively. The X-ray afterglow sho...

  10. GRB090426: the farthest short gamma-ray burst?

    CERN Document Server

    Antonelli, L A; Perna, R; Amati, L; Covino, S; Cutini, S; Elia, V D; Gallozzi, S; Grazian, A; Palazzi, E; Piranomonte, S; Rossi, A; Spiro, S; Stella, L; Testa, V; Chincarini, G; Di Paola, A; Fiore, F; Fugazza, D; Giallongo, E; Maiorano, E; Masetti, N; Pedichini, F; Salvaterra, R; Tagliaferri, G; Vergani, S

    2009-01-01

    Aims. With an observed and rest-frame duration of < 2s and < 0.5s, respectively, GRB090426 could be classified as a short GRB. The prompt detection, both from space and ground-based telescopes, of a bright optical counterpart to this GRB offered a unique opportunity to complete a detailed study. Methods. Based on an extensive ground-based observational campaign, we obtained the spectrum of the optical afterglow of GRB090426, measuring its redshift and obtaining information about the medium in which the event took place. We completed follow-up observation of the afterglow optical light curve down to the brightness level of the host galaxy that we firmly identified and studied. We also retrieved and analyzed all the available high-energy data of this event, and compared the results with our findings in the optical. This represents one of the most detailed studies of a short-duration event presented so far. Results. The time properties qualify GRB090426 as a short burst. In this case, its redshift of z = 2...

  11. Radio rebrightening of the GRB afterglow by the accompanying supernova

    CERN Document Server

    Duran, Rodolfo Barniol

    2015-01-01

    The gamma-ray burst (GRB) jet powers the afterglow emission by shocking the surrounding medium, and radio afterglow can now be routinely observed to almost a year after the explosion. Long-duration GRBs are accompanied by supernovae (SNe) that typically contain much more energy than the GRB jet. Here we consider the fact that the SN blast wave will also produce its own afterglow, which will peak at much later time (since it is non-relativistic), when the SN blast wave transitions from a coasting phase to a decelerating Sedov-Taylor phase. We predict that this component will peak generally a few tens of years after the explosion and it will outshine the GRB powered afterglow well-before its peak emission. In the case of GRB 030329, where the external density is constrained by the $\\sim 10$-year coverage of the radio GRB afterglow, the radio emission is predicted to start rising over the next decade and to continue to increase for the following decades up to a level of $\\sim 0.5$ mJy. Detection of the SN-powere...

  12. GRB Spectra in the complex of synchrotron and Compton processes

    CERN Document Server

    Jiang, Yunguo; Chen, Xu; Li, Kai; Guo, Di-Fu; Li, Yu-Tong; Li, Huai-Zhen; Lin, Hai-Nan; Chang, Zhe

    2015-01-01

    Under the steady state condition, the spectrum of electrons is investigated by solving the continuity equation under the complex radiation of both the synchrotron and Compton processes. The resulted GRB spectrum is a broken power law in both the fast and slow cooling phases. On the basis of this electron spectrum, the spectral indices of the Band function in four different phases are presented. In the complex radiation frame, the detail investigation on physical parameters reveals that both the reverse shock photosphere model and the forward shock with strong coupling model can answer the $\\alpha \\sim -1$ problem. A possible marginal to fast cooling phase transition in GRB 080916C is discussed. The time resolved spectra in different pulses of GRB 100724B, GRB 100826A and GRB 130606B are investigated. We found that the flux is proportional to the peak energy in almost all pulses. The phases for different pulses are determined according to the spectral index revolution. We found the strong correlations between ...

  13. Exploring Broadband GRB Behavior During gamma-ray Emission

    CERN Document Server

    Yost, S A; Rykoff, E S; Aharonian, F; Akerlof, C W; Alday, A; Ashley, M C B; Barthelmy, S; Burrows, D; Depoy, D L; Dufour, R J; Eastman, J D; Forgey, R D; Gehrels, N; G"uver, T; Halpern, J P; Hardin, L C; Horns, D; Krimm, H A; Lepine, S; Liang, E P; Marshall, J L; McKay, T A; Mineo, T; Mirabal, N; Phillips, A; Prieto, J L; Quimby, R M; Romano, P; Rowell, G; Rujopakarn, W; Schaefer, B E; Silverman, J M; Siverd, R; Skinner, M; Smith, D A; Smith, I A; Tonnesen, S; Troja, E; Vestrand, W T; Wheeler, J C; Wren, J; Yuan, F; Zhang, B

    2006-01-01

    The robotic ROTSE-III telescope network detected prompt optical emission contemporaneous with the gamma-ray emission of Swift events GRB051109A and GRB051111. Both datasets have continuous coverage at high signal-to-noise levels from the prompt phase onwards, thus the early observations are readily compared to the Swift XRT and BAT high energy detections. In both cases, the optical afterglow is established, declining steadily during the prompt emission. For GRB051111, there is evidence of an excess optical component during the prompt emission. The component is consistent with the flux spectrally extrapolated from the gamma-rays, using the gamma-ray spectral index. A compilation of spectral information from previous prompt detections shows that such a component is unusual. The existence of two prompt optical components - one connected to the high-energy emission, the other to separate afterglow flux, as indicated in GRB051111 - is not compatible with a simple ``external-external'' shock model for the GRB and i...

  14. The flux-E_p relation within GRB060218 in comparison with typical GRB pulses

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The prompt gamma-ray/X-ray emission of gamma-ray burst(GRB) 060218 was simultaneously observed by the Burst Alert Telescope(BAT) and X-ray Telescope(XRT) onboard Swift.Its peak energy of the joint νfν spectrum(Ep) clearly evolves with time from tens of keV to-1 keV,crossing both the BAT and XRT bands.The best fit yields log Ep=(4.61± 0.23)+(-1.29±0.08) log t,with a correlation coefficient of 0.98 and a chance probability of p<10-4.We derive its bolometric flux(F)in the 0.01-10 4 keV band,and find that its F-Ep relation,with a power-law index of 0.37,is much shallower than that observed in typical GRB pulses.Discussion of this shallowness is presented.

  15. Calibration and Simulation of the GRB trigger detector of the Ultra Fast Flash Observatory

    DEFF Research Database (Denmark)

    Huang, M.-H.A.; Ahmad, S.; Barrillon, P.

    2013-01-01

    The UFFO (Ultra-Fast Flash Observatory) is a GRB detector on board the Lomonosov satellite, to be launched in 2013. The GRB trigger is provided by an X-ray detector, called UBAT (UFFO Burst Alarm & Trigger Telescope), which detects X-rays from the GRB and then triggers to determine the direction ...

  16. Analysis of differentially expressed genes between fluoride-sensitive and fluoride-endurable individuals in midgut of silkworm, Bombyx mori.

    Science.gov (United States)

    Qian, Heying; Li, Gang; He, Qingling; Zhang, Huaguang; Xu, Anying

    2016-08-15

    Fluoride tolerance is an economically important trait of silkworm. Near-isogenic lines (NILs) of the dominant endurance to fluoride (Def) gene in Bombyx mori has been constructed before. Here, we analyzed the gene expression profiles of midgut of fluoride-sensitive and fluoride-endurable individuals of Def NILs by using high-throughput Illumina sequencing technology and bioinformatics tools, and identified differentially expressed genes between these individuals. A total of 3,612,399 and 3,567,631 clean tags for the libraries of fluoride-endurable and fluoride-sensitive individuals were obtained, which corresponded to 32,933 and 43,976 distinct clean tags, respectively. Analysis of differentially expressed genes indicates that 241 genes are differentially expressed between the two libraries. Among the 241 genes, 30 are up-regulated and 211 are down-regulated in fluoride-endurable individuals. Pathway enrichment analysis demonstrates that genes related to ribosomes, pancreatic secretion, steroid biosynthesis, glutathione metabolism, steroid biosynthesis, and glycerolipid metabolism are down-regulated in fluoride-endurable individuals. qRT-PCR was conducted to confirm the results of the DGE. The present study analyzed differential expression of related genes and tried to find out whether the crucial genes were related to fluoride detoxification which might elucidate fluoride effect and provide a new way in the fluorosis research.

  17. State of the art in non-animal approaches for skin sensitization testing: from individual test methods towards testing strategies.

    Science.gov (United States)

    Ezendam, Janine; Braakhuis, Hedwig M; Vandebriel, Rob J

    2016-12-01

    The hazard assessment of skin sensitizers relies mainly on animal testing, but much progress is made in the development, validation and regulatory acceptance and implementation of non-animal predictive approaches. In this review, we provide an update on the available computational tools and animal-free test methods for the prediction of skin sensitization hazard. These individual test methods address mostly one mechanistic step of the process of skin sensitization induction. The adverse outcome pathway (AOP) for skin sensitization describes the key events (KEs) that lead to skin sensitization. In our review, we have clustered the available test methods according to the KE they inform: the molecular initiating event (MIE/KE1)-protein binding, KE2-keratinocyte activation, KE3-dendritic cell activation and KE4-T cell activation and proliferation. In recent years, most progress has been made in the development and validation of in vitro assays that address KE2 and KE3. No standardized in vitro assays for T cell activation are available; thus, KE4 cannot be measured in vitro. Three non-animal test methods, addressing either the MIE, KE2 or KE3, are accepted as OECD test guidelines, and this has accelerated the development of integrated or defined approaches for testing and assessment (e.g. testing strategies). The majority of these approaches are mechanism-based, since they combine results from multiple test methods and/or computational tools that address different KEs of the AOP to estimate skin sensitization potential and sometimes potency. Other approaches are based on statistical tools. Until now, eleven different testing strategies have been published, the majority using the same individual information sources. Our review shows that some of the defined approaches to testing and assessment are able to accurately predict skin sensitization hazard, sometimes even more accurate than the currently used animal test. A few defined approaches are developed to provide an

  18. Sensitization pattern of crustacean-allergic individuals can indicate allergy to molluscs

    DEFF Research Database (Denmark)

    Vidal, C; Bartolomé, B; Rodríguez, V

    2015-01-01

    This study investigated the sensitization pattern of crustacean-allergic patients according to tolerance to molluscs. Thirty-one patients with anaphylaxis to crustaceans (14 with mollusc allergy and 17 with mollusc tolerance) were studied using skin prick tests (SPTs), specific IgEs (sIgEs) and SDS......-PAGE immunoblotting. IgE-reactive shrimp proteins were identified by proteomic analyses. Patients with mollusc allergy presented more frequently SPTs positive to molluscs and higher sIgE titres in response to both molluscs and crustaceans. Shrimp-sIgE and rPen a1-sIgE values of 1.57 kUA /l and 4.38 kUA /l...... = 14) was not different between the two groups. Among patients with crustacean anaphylaxis, patients with mollusc allergy and mollusc tolerance show a different pattern of sensitization, something that may help identify them....

  19. XMM-Newton and Swift observations prove GRB 090709A to be a distant, standard, long GRB

    CERN Document Server

    De Luca, A; Israel, G L; Götz, D; Novara, F; Tiengo, A; Mereghetti, S

    2009-01-01

    GRB 090709A is a long gamma-ray burst (GRB) discovered by Swift, featuring a bright X-ray afterglow as well as a faint infrared transient with very red and peculiar colors. The burst attracted a large interest because of a possible quasi-periodicity at P=8.1 s in the prompt emission, suggesting that it could have a different origin with respect to standard, long GRBs. In order to understand the nature of this burst, we obtained a target of opportunity observation with XMM-Newton. X-ray spectroscopy, based on XMM-Newton and Swift data, allowed us to model the significant excess in photoelectric absorption with respect to the Galactic value as due to a large column density (about 6.5E+22 cm^-2) in the GRB host, located at z=4.2. Such a picture is also consistent with the infrared transient's properties. Re-analysis of the prompt emission, based on INTEGRAL and on Swift data, excludes any significant modulation at P=8.1 s. Thus, we conclude that GRB 090709A is a distant, standard, long GRB.

  20. Sensory Sensitivities and Performance on Sensory Perceptual Tasks in High-Functioning Individuals with Autism

    Science.gov (United States)

    Minshew, Nancy J.; Hobson, Jessica A.

    2008-01-01

    Most reports of sensory symptoms in autism are second hand or observational, and there is little evidence of a neurological basis. Sixty individuals with high-functioning autism and 61 matched typical participants were administered a sensory questionnaire and neuropsychological tests of elementary and higher cortical sensory perception. Thirty-two…

  1. Methods to measure peripheral and central sensitization using quantitative sensory testing: A focus on individuals with low back pain.

    Science.gov (United States)

    Starkweather, Angela R; Heineman, Amy; Storey, Shannon; Rubia, Gil; Lyon, Debra E; Greenspan, Joel; Dorsey, Susan G

    2016-02-01

    Quantitative sensory testing can be used to assess peripheral and central sensitization; important factors that contribute to the individual's experience of pain and disability. Many studies use quantitative sensory testing in patients with low back pain to detect alterations in pain sensitivity, however, because investigators employ different protocols, interpretation of findings across studies can become problematic. The purpose of this article is to propose a standardized method of testing peripheral and central pain sensitization in patients with low back pain. Video clips are provided to demonstrate correct procedures for measuring the response to experimental pain using mechanical, thermal and pressure modalities. As nurse researchers and clinicians increase utilization of quantitative sensory testing to examine pain phenotypes, it is anticipated that more personalized methods for monitoring the trajectory of low back pain and response to treatment will improve outcomes for this patient population. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. GRB Cosmology and Self-organized Criticality in GRBs

    CERN Document Server

    Wang, F Y

    2015-01-01

    Gamma-ray bursts (GRBs), which have isotropic energy up to $10^{54}$ erg, would be the ideal tool to study the properties of early universe: including dark energy, star formation rate, and the metal enrichment history of the Universe. We will briefly review the progress on the field of GRB cosmology. Meanwhile, X-ray flares, which may have important clues to the central engine, are common phenomena in the GRB afterglows. We present statistical results of X-ray flares, i.e., energy, duration time and waiting time distributions, and compare the results with solar flares. The similarity between the two kinds of flares are found, which may indicates that the physical mechanism of GRB X-ray flares is magnetic reconnection.

  3. Circular polarization in the optical afterglow of GRB 121024A

    CERN Document Server

    Wiersema, K; Toma, K; van der Horst, A J; Varela, K; Min, M; Greiner, J; Starling, R L C; Tanvir, N R; Wijers, R A M J; Campana, S; Curran, P A; Fan, Y; Fynbo, J P U; Gorosabel, J; Gomboc, A; Gotz, D; Hjorth, J; Jin, Z P; Kobayashi, S; Kouveliotou, C; Mundell, C; O'Brien, P T; Pian, E; Rowlinson, A; Russell, D M; Salvaterra, R; Alighieri, S di Serego; Tagliaferri, G; Vergani, S D; Elliott, J; Farina, C; Hartoog, O E; Karjalainen, R; Klose, S; Knust, F; Levan, A J; Schady, P; Sudilovski, V; Willingale, R

    2014-01-01

    Gamma-ray bursts (GRBs) are most probably powered by collimated relativistic outflows (jets) from accreting black holes at cosmological distances. Bright afterglows are produced when the outflow collides with the ambient medium. Afterglow polarization directly probes the magnetic properties of the jet, when measured minutes after the burst, and the geometric properties of the jet and the ambient medium when measured hours to days after the burst. High values of optical polarization detected minutes after burst in GRB 120308A indicate the presence of large-scale ordered magnetic fields originating from the central engine (the power source of the GRB). Theoretical models predict low degrees of linear polarization and negligable circular polarization at late times, when the energy in the original ejecta is quickly transferred to the ambient medium and propagates farther into the medium as a blastwave. Here we report the detection of circularly polarized optical light in the afterglow of GRB 121024A, measured 0.1...

  4. An HST study of three very faint GRB host galaxies

    DEFF Research Database (Denmark)

    Jaunsen, A.O.; Andersen, M.I.; Hjorth, J.;

    2003-01-01

    . (2002). We obtain a revised and much higher probability that the galaxies identified as hosts indeed are related to the GRBs (P(n(chance))=0.69, following Bloom et al. 2002), thereby strengthening the conclusion that GRBs are preferentially located in star-forming regions in their hosts. Apart from......As part of the HST/STIS GRB host survey program we present the detection of three faint gamma-ray burst (GRB) host galaxies based on an accurate localisation using ground-based data of the optical afterglows (OAs). A common property of these three hosts is their extreme faintness. The location...... at which GRBs occur with respect to their host galaxies and surrounding environments are robust indicators of the nature of GRB progenitors. The bursts studied here are among the four most extreme outliers, in terms of relative distance from the host center, in the recent comprehensive study of Bloom et al...

  5. Short GRB 130603B: Discovery of a jet break in the optical and radio afterglows, and a mysterious late-time X-ray excess

    Energy Technology Data Exchange (ETDEWEB)

    Fong, W.; Berger, E.; Margutti, R.; Chornock, R.; Migliori, G.; Zauderer, B. A.; Lunnan, R.; Laskar, T. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Metzger, B. D. [Department of Physics and Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027 (United States); Foley, R. J. [Astronomy Department, University of Illinois at Urbana-Champaign, 1002 W. Green Street, Urbana, IL 61801 (United States); Desch, S. J. [School of Earth and Space Exploration, Arizona State University, P.O. Box 871404, Tempe, AZ 85287-1404 (United States); Meech, K. J.; Sonnett, S. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Dickey, C.; Hedlund, A. [Pomona College, 610 N. College Ave., Claremont, CA 91711 (United States); Harding, P. [Department of Astronomy, Case Western Reserve University, Cleveland, OH 44106-7215 (United States)

    2014-01-10

    We present radio, optical/NIR, and X-ray observations of the afterglow of the short-duration Swift and Konus-Wind GRB 130603B, and uncover a break in the radio and optical bands at ≈0.5 day after the burst, best explained as a jet break with an inferred jet opening angle of ≈4°-8°. GRB 130603B is only the third short GRB with a radio afterglow detection to date, and represents the first time that a jet break has been evident in the radio band. We model the temporal evolution of the spectral energy distribution to determine the burst explosion properties and find an isotropic-equivalent kinetic energy of ≈(0.6-1.7) × 10{sup 51} erg and a circumburst density of ≈5 × 10{sup –3}-30 cm{sup –3}. From the inferred opening angle of GRB 130603B, we calculate beaming-corrected energies of E {sub γ} ≈ (0.5-2) × 10{sup 49} erg and E {sub K} ≈ (0.1-1.6) × 10{sup 49} erg. Along with previous measurements and lower limits we find a median opening angle of ≈10°. Using the all-sky observed rate of 10 Gpc{sup –3} yr{sup –1}, this implies a true short GRB rate of ≈20 yr{sup –1} within 200 Mpc, the Advanced LIGO/VIRGO sensitivity range for neutron star binary mergers. Finally, we uncover evidence for significant excess emission in the X-ray afterglow of GRB 130603B at ≳ 1 day and conclude that the additional energy component could be due to fall-back accretion or spin-down energy from a magnetar formed following the merger.

  6. A New Approach to Measuring Individual Differences in Sensitivity to Facial Expressions: Influence of Temperamental Shyness and Sociability

    Directory of Open Access Journals (Sweden)

    Xiaoqing eGao

    2014-02-01

    Full Text Available To examine individual differences in adults’ sensitivity to facial expressions, we used a novel method that has proved revealing in studies of developmental change. Using static faces morphed to show different intensities of facial expressions, we calculated two measures: (1 the threshold to detect that a low intensity facial expression is different from neutral, and (2 accuracy in recognizing the specific facial expression in faces above the detection threshold. We conducted two experiments with young adult females varying in reported temperamental shyness and sociability - the former trait is known to influence the recognition of facial expressions during childhood. In both experiments, the measures had good split half reliability. Because shyness was significantly negatively correlated with sociability, we used partial correlations to examine the relation of each to sensitivity to facial expression. Sociability was negatively related to threshold to detect fear (Experiment 1 and to misidentify fear as another expression or happy expressions as fear (Experiment 2. Both patterns are consistent with hypervigilance by less sociable individuals. Shyness was positively related to misidentification of fear as another emotion (Experiment 2, a pattern consistent with a history of avoidance. We discuss the advantages and limitations of this new approach for studying individual differences in sensitivity to facial expression.

  7. Big-data-based edge biomarkers: study on dynamical drug sensitivity and resistance in individuals.

    Science.gov (United States)

    Zeng, Tao; Zhang, Wanwei; Yu, Xiangtian; Liu, Xiaoping; Li, Meiyi; Chen, Luonan

    2016-07-01

    Big-data-based edge biomarker is a new concept to characterize disease features based on biomedical big data in a dynamical and network manner, which also provides alternative strategies to indicate disease status in single samples. This article gives a comprehensive review on big-data-based edge biomarkers for complex diseases in an individual patient, which are defined as biomarkers based on network information and high-dimensional data. Specifically, we firstly introduce the sources and structures of biomedical big data accessible in public for edge biomarker and disease study. We show that biomedical big data are typically 'small-sample size in high-dimension space', i.e. small samples but with high dimensions on features (e.g. omics data) for each individual, in contrast to traditional big data in many other fields characterized as 'large-sample size in low-dimension space', i.e. big samples but with low dimensions on features. Then, we demonstrate the concept, model and algorithm for edge biomarkers and further big-data-based edge biomarkers. Dissimilar to conventional biomarkers, edge biomarkers, e.g. module biomarkers in module network rewiring-analysis, are able to predict the disease state by learning differential associations between molecules rather than differential expressions of molecules during disease progression or treatment in individual patients. In particular, in contrast to using the information of the common molecules or edges (i.e.molecule-pairs) across a population in traditional biomarkers including network and edge biomarkers, big-data-based edge biomarkers are specific for each individual and thus can accurately evaluate the disease state by considering the individual heterogeneity. Therefore, the measurement of big data in a high-dimensional space is required not only in the learning process but also in the diagnosing or predicting process of the tested individual. Finally, we provide a case study on analyzing the temporal expression

  8. Age-dependent atypicalities in body- and face-sensitive activation of the EBA and FFA in individuals with ASD.

    Science.gov (United States)

    Okamoto, Yuko; Kosaka, Hirotaka; Kitada, Ryo; Seki, Ayumi; Tanabe, Hiroki C; Hayashi, Masamichi J; Kochiyama, Takanori; Saito, Daisuke N; Yanaka, Hisakazu T; Munesue, Toshio; Ishitobi, Makoto; Omori, Masao; Wada, Yuji; Okazawa, Hidehiko; Koeda, Tatsuya; Sadato, Norihiro

    2017-06-01

    Individuals with autism spectrum disorder (ASD) have difficuly in recognizing bodies and faces, which are more pronounced in children than adults. If such difficulties originate from dysfunction of the extrastriate body area (EBA) and the fusiform face area (FFA), activation in these regions might be more atypical in children than in adults. We preformed functional magnetic resonance imaging while children and adults with ASD and age-matched typically developed (TD) individuals observed face, body, car, and scene. To examine various aspects, we performed individual region of interest (ROI) analysis, as well as conventional random effect group analysis. At individual ROI analysis, we examined the ratio of participants showing a category-sensitive response, the size of regions, location and activation patterns among the four object categories. Adults with ASD showed no atypicalities in activation of the EBA and FFA, whereas children with ASD showed atypical activation in these regions. Specifically, a smaller percentage of children with ASD showed face-sensitive activation of the FFA than TD children. Moreover, the size of the EBA was smaller in children with ASD than in TD children. Our results revealed atypicalities in both the FFA and EBA in children with ASD but not in adults with ASD. Copyright © 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.

  9. GRB Polarization Measurements with CGRO/COMPTEL

    Science.gov (United States)

    McConnell, Mark L.; Collmar, Werner

    2016-04-01

    We have embarked on a program to analyze CGRO/COMPTEL data in search for evidence of polarization in both transient sources and in brighter steady sources. We are pursuing this work because of the heightened interest in high energy polarimetry, the recognition that some high energy sources may be highly polarized (thus improving our chances of a making useful measurements), and the ready availability of modern computing resources that provide the ability to carry out more comprehensive simulations in support of the analysis. The only significant work done to date with regards to COMPTEL polarimetry was published almost 20 years ago and used a simplified mass model of COMPTEL for simulating the instrument response. Estimates of the minimum detectable polarization (MDP) near 1 MeV included 30% for a two-week observation of the Crab, as low as 10% for bright GRBs, and as low as 10% for bright solar flares. The data analysis performed at the time led to inconclusive results and suggested some unknown systematic error. We contend that a self-consistent analysis will be feasible with high fidelity simulations, simulations that were not easily generated 20 years ago. Our analysis utilizes the latest GEANT4 simulation tools in conjunction with a high-fidelity mass model of the COMPTEL instrument, and incorporate updated analysis tools originally developed by the COMPTEL collaboration. Given the nine years of COMPTEL data, we expect that this work will likely add to our understanding of the polarization properties of transient sources, such as GRBs and solar flares, as well as brighter steady sources, such as the Crab and Cyg X-1. Here we present results from simulations of the COMPTEL polarization response and examine prospects for studying GRB polarization.

  10. ROAT: morphology of ROAT on arm, neck and face in formaldehyde and diazolidinyl urea sensitive individuals

    DEFF Research Database (Denmark)

    Zachariae, Claus; Hall, Barbara; Cupferman, Sylvie

    2006-01-01

    The morphology of early allergic contact dermatitis reactions was studied in formaldehyde allergic individuals exposed to a cream product preserved with 4 different concentrations of diazolidinyl urea. The study was made using a dose-escalating design in 3 different anatomical regions, the upper ...... arm, neck and face. On the arm and neck, the dominant initial morphology was an eczematous papular eruption. In the face, the initial skin changes were more homogeneous and infiltrated erythema....

  11. Sensitive Detection of Individual Neutral Atoms in a Strong Coupling Cavity QED System

    Institute of Scientific and Technical Information of China (English)

    ZHANG Peng-Fei; ZHANG Yu-Chi; LI Gang; DU Jin-Jin; ZHANG Yan-Feng; GUO Yan-Qiang; WANG Jun-Min; ZHANG Tian-Cai; LI Wei-Dong

    2011-01-01

    We experimentally demonstrate real-time detection of individual cesium atoms by using a high-finesse optical micro-cavity in a strong coupling regime.A cloud of cesium atoms is trapped in a magneto-optical trap positioned at 5 mm above the micro-cavity center.The atoms fall down freely in gravitation after shutting off the magnetooptical trap and pass through the cavity.The cavity transmission is strongly affected by the atoms in the cavity, which enables the micro-cavity to sense the atoms individually.We detect the single atom transits either in the resonance or various detunings.The single atom vacuum-Rabi splitting is directly measured to be Ω = 2π × 23.9 MHz.The average duration of atom-cavity coupling of about 110μs is obtained according to the probability distribution of the atom transits.%@@ We experimentally demonstrate real-time detection of individual cesium atoms by using a high-finesse optical micro-cavity in a strong coupling regime.A cloud of cesium atoms is trapped in a magneto-optical trap positioned at 5mm above the micro-cavity center.The atoms fall down freely in gravitation after shutting off the magnetooptical trap and pass through the cavity.The cavity transmission is strongly affected by the atoms in the cavity, which enables the micro-cavity to sense the atoms individually.We detect the single atom transits either in the resonance or various detunings.The single atom vacuum-Rabi splitting is directly measured to be Ω=2π×23.9 MHz.The average duration of atom-cavity coupling of about 110μs is obtained according to the probability distribution of the atom transits.

  12. Circular polarization in the optical afterglow of GRB 121024A

    DEFF Research Database (Denmark)

    Wiersema, K.; Covino, S.; Toma, K.

    2014-01-01

    of the jet, when measured minutes after the burst, and the geometric properties of the jet and the ambient medium when measured hours to days after the burst. High values of optical polarization detected minutes after burst in GRB 120308A indicate the presence of large-scale ordered magnetic fields...... originating from the central engine (the power source of the GRB). Theoretical models predict low degrees of linear polarization and negligable circular polarization at late times, when the energy in the original ejecta is quickly transferred to the ambient medium and propagates farther into the medium...

  13. The Early Optical Brightening in the GRB 071010B

    Energy Technology Data Exchange (ETDEWEB)

    Wang, J H; Schwamb, M E; Huang, K Y; Wen, C Y; Zhang, Z W; Wang, S Y; Chen, W P; Bianco, F B; Dave, R; Lehner, M J; Marshall, S L; Porrata, R; Alcock, C; Byun, Y I; Cook, K H; King, S K; Lee, T; Urata, Y

    2008-04-08

    We report the detection of early (60-230 s) optical emission of the gamma-ray burst afterglow of GRB071010B. No significant correlation with the prompt {gamma}-ray emission was found. Our high time-resolution data combining with other measurements within 2 days after the burst indicate that GRB071010B is composed of a weak early brightening ({alpha} {approx} 0.6), probably caused by the peak frequency passing through the optical wavelengths, followed by a decay ({alpha} {approx} -0.51), attributed to continuous energy injection by patchy jets.

  14. GRB Afterglows and Other Transients in the SDSS

    OpenAIRE

    Lee, Brian C.; Reichart, Daniel E.

    2003-01-01

    The Sloan Digital Sky Survey (SDSS) will image one quarter of the sky centered on the northern galactic cap and produce a 3-D map of galaxies and quasars found in the sample. An additional 225 deg^2 southern survey will be imaged repeatedly on varying timescales. Here we discuss both archival searches in the SDSS catalog (such as SDSS J24602.54+011318.8) and active searches with the SDSS instruments (such as for GRB 010222) for GRB afterglows and other transient objects.

  15. Is pressure pain sensitivity over the cervical musculature associated with neck disability in individuals with migraine?

    Science.gov (United States)

    Gonçalves, Maria Claudia; Chaves, Thaís Cristina; Florencio, Lidiane Lima; Carvalho, Gabriela Ferreira; Dach, Fabíola; Fernández-De-Las-Penãs, Cesar; Bevilaqua-Grossi, Débora

    2015-01-01

    The objective was to determine if disability due to neck pain is correlated with pressure pain sensitivity in the cervical muscles in patients with migraine. Thirty-two volunteers with migraine completed the Neck Disability Index (NDI). Pressure pain thresholds (PPT) over the sternocleidomastoid, upper trapezius and suboccipital muscles were also assessed. Data were analyzed using the Spearman correlation coefficient (rs) and linear regression models (α cervical muscles correlated moderately and was inversely proportional in patients with migraine, but the association was not linear, so both outcomes should be considered in the assessment of this population.

  16. Sensitization pattern of crustacean-allergic individuals can indicate allergy to molluscs.

    Science.gov (United States)

    Vidal, C; Bartolomé, B; Rodríguez, V; Armisén, M; Linneberg, A; González-Quintela, A

    2015-11-01

    This study investigated the sensitization pattern of crustacean-allergic patients according to tolerance to molluscs. Thirty-one patients with anaphylaxis to crustaceans (14 with mollusc allergy and 17 with mollusc tolerance) were studied using skin prick tests (SPTs), specific IgEs (sIgEs) and SDS-PAGE immunoblotting. IgE-reactive shrimp proteins were identified by proteomic analyses. Patients with mollusc allergy presented more frequently SPTs positive to molluscs and higher sIgE titres in response to both molluscs and crustaceans. Shrimp-sIgE and rPen a1-sIgE values of 1.57 kUA /l and 4.38 kUA /l, respectively, showed positive likelihood ratios of 4.3 and 10.9 for the identification of mollusc allergy. Patients with mollusc allergy reacted more frequently to tropomyosin in immunoblots than did patients without it (93% vs 35%, respectively, P = 0.004). Reactivity to proteins other than tropomyosin (n = 14) was not different between the two groups. Among patients with crustacean anaphylaxis, patients with mollusc allergy and mollusc tolerance show a different pattern of sensitization, something that may help identify them. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  17. Monitoring Integrated Activity of Individual Neurons Using FRET-Based Voltage-Sensitive Dyes.

    Science.gov (United States)

    Briggman, Kevin L; Kristan, William B; González, Jesús E; Kleinfeld, David; Tsien, Roger Y

    2015-01-01

    Pairs of membrane-associated molecules exhibiting fluorescence resonance energy transfer (FRET) provide a sensitive technique to measure changes in a cell's membrane potential. One of the FRET pair binds to one surface of the membrane and the other is a mobile ion that dissolves in the lipid bilayer. The voltage-related signal can be measured as a change in the fluorescence of either the donor or acceptor molecules, but measuring their ratio provides the largest and most noise-free signal. This technology has been used in a variety of ways; three are documented in this chapter: (1) high throughput drug screening, (2) monitoring the activity of many neurons simultaneously during a behavior, and (3) finding synaptic targets of a stimulated neuron. In addition, we provide protocols for using the dyes on both cultured neurons and leech ganglia. We also give an updated description of the mathematical basis for measuring the coherence between electrical and optical signals. Future improvements of this technique include faster and more sensitive dyes that bleach more slowly, and the expression of one of the FRET pair genetically.

  18. Higher sensitivity to sweet and salty taste in obese compared to lean individuals.

    Science.gov (United States)

    Hardikar, Samyogita; Höchenberger, Richard; Villringer, Arno; Ohla, Kathrin

    2017-04-01

    Although putatively taste has been associated with obesity as one of the factors governing food intake, previous studies have failed to find a consistent link between taste perception and Body Mass Index (BMI). A comprehensive comparison of both thresholds and hedonics for four basic taste modalities (sweet, salty, sour, and bitter) has only been carried out with a very small sample size in adults. In the present exploratory study, we compared 23 obese (OB; BMI > 30), and 31 lean (LN; BMI salty), citric acid (sour), and quinine hydrochloride (bitter) dissolved in water. Recognition thresholds were estimated with an adaptive Bayesian staircase procedure (QUEST). Intensity and pleasantness ratings were acquired using visual analogue scales (VAS). It was found that OB had lower thresholds than LN for sucrose and NaCl, indicating a higher sensitivity to sweet and salty tastes. This effect was also reflected in ratings of intensity, which were significantly higher in the OB group for the lower concentrations of sweet, salty, and sour. Calculation of Bayes factors further corroborated the differences observed with null-hypothesis significance testing (NHST). Overall, the results suggest that OB are more sensitive to sweet and salty, and perceive sweet, salty, and sour more intensely than LN. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Pholcodine stimulates a dramatic increase of IgE in IgE-sensitized individuals. A pilot study.

    Science.gov (United States)

    Florvaag, E; Johansson, S G O; Oman, H; Harboe, T; Nopp, A

    2006-01-01

    A previous study showed a relation between pholcodine (PHO) consumption, prevalence of IgE-sensitization to PHO, morphine (MOR) and suxamethonium (SUX) and anaphylaxis to neuromuscular blocking agents (NMBA). The purpose of this pilot study was to explore the effect on IgE production, in IgE-sensitized and nonsensitized individuals, of exposure to cough syrup and environmental chemicals containing PHO, MOR and SUX related allergenic structures. Serum concentrations of IgE and IgE antibodies to PHO, MOR and SUX allergens measured by ImmunoCAP (Pharmacia Diagnostics, Uppsala, Sweden) were followed after intake of cough syrup, or exposure to confectionary and other household chemicals containing various amounts of substances cross-reacting with PHO, MOR and SUX. Cough syrup containing PHO gave, in sensitized individuals, within 1-2 weeks, an increase of IgE of 60-105 times and of IgE antibodies to PHO, MOR and SUX in the order of 30-80 times. The tested confectionary did not have any similar stimulating effect but seemed to counteract the expected decrease of IgE. No effect was seen in nonsensitized individuals. The PHO stimulated IgE showed a nonspecific binding to ImmunoCAP with common allergens and glycine background ImmunoCAP that was up to 10-fold higher than that of monomeric myeloma-IgE at twice the concentration. It seems as cough syrups containing PHO have a most remarkable IgE boostering effect in persons IgE-sensitized to PHO, MOR and SUX related allergens. Household chemicals containing such allergenic epitopes seem capable of some, minor, stimulation.

  20. Temporal variability of GRB early X-ray afterglows and GRB080319B prompt emission

    CERN Document Server

    Margutti, R; Chincarini, G; Pasotti, F; Covino, S; Mao, J

    2008-01-01

    We performed the first systematic search for the minimum variability time scale between 0.3 and 10 keV studying the 28 brightest early (<3000 s) afterglows detected by Swift-XRT up to March 2008. We adopt the power spectrum analysis in the time domain: unlike the Fourier spectrum, this is suitable to study the rms variations at different time-scales. We find that early XRT afterglows show variability in excess of the Poissonian noise level on time-scales as short as about 1 s (rest frame value), with the shortest t_{min} associated with the highest energy band. The gamma-ray prompt emission of GRB080319B shows a characteristic average variability time-scale t_{var} of about 1s; this parameter undergoes a remarkable evolution during the prompt emission (BAT observation).

  1. On the Sensitivity of the HAWC Observatory to Gamma-Ray Bursts

    Science.gov (United States)

    Hays, E.; McEnery, Julie E.

    2011-01-01

    We present the sensitivity of HAWC to Gamma Ray Bursts (GRBs). HAWC is a very high-energy gamma-ray observatory currently under construction in Mexico at an altitude of 4100 m. It will observe atmospheric air showers via the water Cherenkov method. HAWC will consist of 300 large water tanks instrumented with 4 photomultipliers each. HAWC has two data acquisition (DAQ) systems. The main DAQ system reads out coincident signals in the tanks and reconstructs the direction and energy of individual atmospheric showers. The scaler DAQ counts the hits in each photomultiplier tube (PMT) in the detector and searches for a statistical excess over the noise of all PMTs. We show that HAWC has a realistic opportunity to observe the high-energy power law components of GRBs that extend at least up to 30 GeV, as it has been observed by Fermi LAT. The two DAQ systems have an energy threshold that is low enough to observe events similar to GRB 090510 and GRB 090902b with the characteristics observed by Fermi LAT. HAWC will provide information about the high-energy spectra of GRBs which in turn will lead to understanding about e-pair attenuation in GRB jets, extragalactic background light absorption, as well as establishing the highest energy to which GRBs accelerate particles.

  2. SENSITIVITY AND SPECIFICITY OF INDIVIDUAL BERG BALANCE ITEMS COMPARED WITH THE TOTAL SCORE TO PREDICT FALLS IN COMMUNITY DWELLING ELDERLY INDIVIDUALS

    Directory of Open Access Journals (Sweden)

    Hazel Denzil Dias

    2014-06-01

    Full Text Available Background: Falls are a major problem in the elderly leading to increased morbidity and mortality in this population. Scores from objective clinical measures of balance have frequently been associated with falls in older adults. The Berg Balance Score (BBS which is a frequently used scale to test balance impairments in the elderly ,takes time to perform and has been found to have scoring inconsistencies. The purpose was to determine if individual items or a group of BBS items would have better accuracy than the total BBS in classifying community dwelling elderly individuals according to fall history. Method: 60 community dwelling elderly individuals were chosen based on a history of falls in this cross sectional study. Each BBS item was dichotomized at three points along the scoring scale of 0 – 4: between scores of 1 and 2, 2 and 3, and 3 and 4. Sensitivity (Sn, specificity (Sp, and positive (+LR and negative (-LR likelihood ratios were calculated for all items for each scoring dichotomy based on their accuracy in classifying subjects with a history of multiple falls. These findings were compared with the total BBS score where the cut-off score was derived from receiver operating characteristic curve analysis. Results: On analysing a combination of BBS items, B9 and B11 were found to have the best sensitivity and specificity when considered together. However the area under the curve of these items was 0.799 which did not match that of the total score (AUC= 0.837. A, combination of 4 BBS items - B9 B11 B12 and B13 also had good Sn and Sp but the AUC was 0.815. The combination with the AUC closest to that of the total score was a combination items B11 and B13. (AUC= 0.824. hence these two items can be used as the best predictor of falls with a cut off of 6.5 The ROC curve of the Total Berg balance Scale scores revealed a cut off score of 48.5. Conclusion: This study showed that combination of items B11 and B13 may be best predictors of falls in

  3. SENSITIVITY AND SPECIFICITY OF INDIVIDUAL BERG BALANCE ITEMS COMPARED WITH THE TOTAL SCORE TO PREDICT FALLS IN COMMUNITY DWELLING ELDERLY INDIVIDUALS

    Directory of Open Access Journals (Sweden)

    Hazel Denzil Dias

    2014-09-01

    Full Text Available Background: Falls are a major problem in the elderly leading to increased morbidity and mortality in this population. Scores from objective clinical measures of balance have frequently been associated with falls in older adults. The Berg Balance Score (BBS which is a frequently used scale to test balance impairments in the elderly ,takes time to perform and has been found to have scoring inconsistencies. The purpose was to determine if individual items or a group of BBS items would have better accuracy than the total BBS in classifying community dwelling elderly individuals according to fall history. Method: 60 community dwelling elderly individuals were chosen based on a history of falls in this cross sectional study. Each BBS item was dichotomized at three points along the scoring scale of 0 – 4: between scores of 1 and 2, 2 and 3, and 3 and 4. Sensitivity (Sn, specificity (Sp, and positive (+LR and negative (-LR likelihood ratios were calculated for all items for each scoring dichotomy based on their accuracy in classifying subjects with a history of multiple falls. These findings were compared with the total BBS score where the cut-off score was derived from receiver operating characteristic curve analysis. Results: On analysing a combination of BBS items, B9 and B11 were found to have the best sensitivity and specificity when considered together. However the area under the curve of these items was 0.799 which did not match that of the total score (AUC= 0.837. A, combination of 4 BBS items - B9 B11 B12 and B13 also had good Sn and Sp but the AUC was 0.815. The combination with the AUC closest to that of the total score was a combination items B11 and B13. (AUC= 0.824. hence these two items can be used as the best predictor of falls with a cut off of 6.5 The ROC curve of the Total Berg balance Scale scores revealed a cut off score of 48.5. Conclusion: This study showed that combination of items B11 and B13 may be best predictors of falls in

  4. High sensitive troponin T in individuals with chest pain of presumed ischemic origin.

    Science.gov (United States)

    Cuda, Giovanni; Lentini, Margherita; Gallo, Luigia; Lucia, Fortunata G; Giacinto Carinci, Lorenzina; Mancuso, Serafina; Biondi, Rosa A; Sinopoli, Raffaella; Casadonte, Rita; Guzzi, Pietro H; Cannataro, Mario; Mongiardo, Annalisa; Iaconetti, Claudio; Bochicchio, Angela; Curcio, Antonio; Torella, Daniele; Ricci, Pietroantonio; Indolfi, Ciro; Costanzo, Francesco

    2012-06-01

    This study was aimed at assessing the bias of high sensitive cardiac troponin T vs. the standard cardiac troponin T in a selected population with chest pain of presumed cardiac origin. Serum cTnT was determined in 132 patients and in 106 apparently healthy controls by both assays. The hs-cTnT outperformed the standard generation assay by: i) allowing a larger and earlier diagnosis of AMI (74.2 percent vs. 64.3 percent patients resulted positive at the final diagnosis of AMI when tested with the hs-cTnT or the std-cTnT assay, respectively); ii) showing a better time-dependent dynamics in patients with AMI due to a higher precision at low concentrations; iii) identifying, within the controls, 6 subjects in whom a further examination revealed the presence of chronic asymptomatic cardiac ischemia. The results underscore the excellent performance of the hs-cTnT assay in our population. The use of this test can thus be strongly recommended in subjects presenting to the emergency unit with chest pain of presumed ischemic origin in order to increase the probability of earlier diagnosis of AMI, especially in non-STEMI.

  5. Individual Differences in Scotopic Visual Acuity and Contrast Sensitivity: Genetic and Non-Genetic Influences.

    Directory of Open Access Journals (Sweden)

    Alex J Bartholomew

    Full Text Available Despite the large amount of variation found in the night (scotopic vision capabilities of healthy volunteers, little effort has been made to characterize this variation and factors, genetic and non-genetic, that influence it. In the largest population of healthy observers measured for scotopic visual acuity (VA and contrast sensitivity (CS to date, we quantified the effect of a range of variables on visual performance. We found that young volunteers with excellent photopic vision exhibit great variation in their scotopic VA and CS, and this variation is reliable from one testing session to the next. We additionally identified that factors such as Circadian preference, iris color, astigmatism, depression, sex and education have no significant impact on scotopic visual function. We confirmed previous work showing that the amount of time spent on the vision test influences performance and that laser eye surgery results in worse scotopic vision. We also showed a significant effect of intelligence and photopic visual performance on scotopic VA and CS, but all of these variables collectively explain <30% of the variation in scotopic vision. The wide variation seen in young healthy volunteers with excellent photopic vision, the high test-retest agreement, and the vast majority of the variation in scotopic vision remaining unexplained by obvious non-genetic factors suggests a strong genetic component. Our preliminary genome-wide association study (GWAS of 106 participants ruled out any common genetic variants of very large effect and paves the way for future, larger genetic studies of scotopic vision.

  6. IMPLICATIONS FOR THE ORIGIN OF GRB 051103 FROM LIGO OBSERVATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Abadie, J.; Abbott, B. P.; Abbott, R.; Adhikari, R.; Ajith, P.; Anderson, S. B.; Arai, K.; Araya, M. C. [LIGO-California Institute of Technology, Pasadena, CA 91125 (United States); Abbott, T. D. [California State University Fullerton, Fullerton, CA 92831 (United States); Abernathy, M. [University of Glasgow, Glasgow G12 8QQ (United Kingdom); Adams, C. [LIGO-Livingston Observatory, Livingston, LA 70754 (United States); Affeldt, C.; Allen, B. [Albert-Einstein-Institut, Max-Planck-Institut fuer Gravitationsphysik, D-30167 Hannover (Germany); Allen, G. S. [Stanford University, Stanford, CA 94305 (United States); Ceron, E. Amador; Anderson, W. G. [University of Wisconsin-Milwaukee, Milwaukee, WI 53201 (United States); Amariutei, D.; Arain, M. A. [University of Florida, Gainesville, FL 32611 (United States); Amin, R. S. [Louisiana State University, Baton Rouge, LA 70803 (United States); Aston, S. M. [University of Birmingham, Birmingham B15 2TT (United Kingdom); Collaboration: LIGO Collaboration; and others

    2012-08-10

    We present the results of a LIGO search for gravitational waves (GWs) associated with GRB 051103, a short-duration hard-spectrum gamma-ray burst (GRB) whose electromagnetically determined sky position is coincident with the spiral galaxy M81, which is 3.6 Mpc from Earth. Possible progenitors for short-hard GRBs include compact object mergers and soft gamma repeater (SGR) giant flares. A merger progenitor would produce a characteristic GW signal that should be detectable at a distance of M81, while GW emission from an SGR is not expected to be detectable at that distance. We found no evidence of a GW signal associated with GRB 051103. Assuming weakly beamed {gamma}-ray emission with a jet semi-angle of 30 Degree-Sign , we exclude a binary neutron star merger in M81 as the progenitor with a confidence of 98%. Neutron star-black hole mergers are excluded with >99% confidence. If the event occurred in M81, then our findings support the hypothesis that GRB 051103 was due to an SGR giant flare, making it one of the most distant extragalactic magnetars observed to date.

  7. Implications For The Origin Of GRB 051103 From LIGO Observations

    CERN Document Server

    Abadie, J; Abbott, T D; Abbott, R; Abernathy, M; Adams, C; Adhikari, R; Affeldt, C; Ajith, P; Allen, B; Allen, G S; Ceron, E Amador; Amariutei, D; Amin, R S; Anderson, S B; Anderson, W G; Arai, K; Arain, M A; Araya, M C; Aston, S M; Atkinson, D; Aufmuth, P; Aulbert, C; Aylott, B E; Babak, S; Baker, P; Ballmer, S; Barker, D; Barnum, S; Barr, B; Barriga, P; Barsotti, L; Barton, M A; Bartos, I; Bassiri, R; Bastarrika, M; Bauchrowitz, J; Behnke, B; Bell, A S; Belopolski, I; Benacquista, M; Bertolini, A; Betzwieser, J; Beveridge, N; Beyersdorf, P T; Bilenko, I A; Billingsley, G; Birch, J; Biswas, R; Black, E; Blackburn, J K; Blackburn, L; Blair, D; Bland, B; Bock, O; Bodiya, T P; Bogan, C; Bondarescu, R; Bork, R; Born, M; Bose, S; Boyle, M; Brady, P R; Braginsky, V B; Brau, J E; Breyer, J; Bridges, D O; Brinkmann, M; Britzger, M; Brooks, A F; Brown, D A; Brummitt, A; Buonanno, A; Burguet-Castell, J; Burmeister, O; Byer, R L; Cadonati, L; Camp, J B; Campsie, P; Cannizzo, J; Cannon, K; Cao, J; Capano, C; Caride, S; Caudill, S; Cavaglia, M; Cepeda, C; Chalermsongsak, T; Chalkley, E; Charlton, P; Chelkowski, S; Chen, Y; Christensen, N; Chua, S S Y; Chung, S; Chung, C T Y; Clara, F; Clark, D; Clark, J; Clayton, J H; Conte, R; Cook, D; Corbitt, T R C; Cornish, N; Costa, C A; Coughlin, M; Coward, D M; Coyne, D C; Creighton, J D E; Creighton, T D; Cruise, A M; Cumming, A; Cunningham, L; Culter, R M; Dahl, K; Danilishin, S L; Dannenberg, R; Danzmann, K; Das, K; Daudert, B; Daveloza, H; Davies, G; Daw, E J; Dayanga, T; DeBra, D; Degallaix, J; Dent, T; Dergachev, V; DeRosa, R; DeSalvo, R; Dhurandhar, S; Di Palma, I; Diaz, M; Donovan, F; Dooley, K L; Dorsher, S; Douglas, E S D; Drever, R W P; Driggers, J C; Dumas, J -C; Dwyer, S; Eberle, T; Edgar, M; Edwards, M; Effler, A; Ehrens, P; Engel, R; Etzel, T; Evans, M; Evans, T; Factourovich, M; Fairhurst, S; Fan, Y; Farr, B F; Fazi, D; Fehrmann, H; Feldbaum, D; Finn, L S; Flanigan, M; Foley, S; Forsi, E; Fotopoulos, N; Frede, M; Frei, M; Frei, Z; Freise, A; Frey, R; Fricke, T T; Friedrich, D; Fritschel, P; Frolov, V V; Fulda, P; Fyffe, M; Garcia, J; Garofoli, J A; Gholami, I; Ghosh, S; Giaime, J A; Giampanis, S; Giardina, K D; Gill, C; Goetz, E; Goggin, L M; Gonzalez, G; Gorodetsky, M L; Gossler, S; Graef, C; Grant, A; Gras, S; Gray, C; Greenhalgh, R J S; Gretarsson, A M; Grosso, R; Grote, H; Grunewald, S; Guido, C; Gupta, R; Gustafson, E K; Gustafson, R; Hage, B; Hallam, J M; Hammer, D; Hammond, G; Hanks, J; Hanna, C; Hanson, J; Harms, J; Harry, G M; Harry, I W; Harstad, E D; Hartman, M T; Haughian, K; Hayama, K; Heefner, J; Hendry, M A; Heng, I S; Heptonstall, A W; Herrera, V; Hewitson, M; Hild, S; Hoak, D; Hodge, K A; Holt, K; Hong, T; Hooper, S; Hosken, D J; Hough, J; Howell, E J; Hughey, B; Husa, S; Huttner, S H; Ingram, D R; Inta, R; Isogai, T; Ivanov, A; Johnson, W W; Jones, D I; Jones, G; Jones, R; Ju, L; Kalmus, P; Kalogera, V; Kandhasamy, S; Kanner, J B; Katsavounidis, E; Katzman, W; Kawabe, K; Kawamura, S; Kawazoe, F; Kells, W; Kelner, M; Keppel, D G; Khalaidovski, A; Khalili, F Y; Khazanov, E A; Kim, N; Kim, H; King, P J; Kinzel, D L; Kissel, J S; Klimenko, S; Kondrashov, V; Kopparapu, R; Koranda, S; Korth, W Z; Kozak, D; Kringel, V; Krishnamurthy, S; Krishnan, B; Kuehn, G; Kumar, R; Kwee, P; Landry, M; Lantz, B; Lastzka, N; Lazzarini, A; Leaci, P; Leong, J; Leonor, I; Li, J; Lindquist, P E; Lockerbie, N A; Lodhia, D; Lormand, M; Lu, P; Luan, J; Lubinski, M; Luck, H; Lundgren, A P; Macdonald, E; Machenschalk, B; MacInnis, M; Mageswaran, M; Mailand, K; Mandel, I; Mandic, V; Marandi, A; Marka, S; Marka, Z; Maros, E; Martin, I W; Martin, R M; Marx, J N; Mason, K; Matichard, F; Matone, L; Matzner, R A; Mavalvala, N; McCarthy, R; McClelland, D E; McGuire, S C; McIntyre, G; McIver, J; McKechan, D J A; Meadors, G; Mehmet, M; Meier, T; Melatos, A; Melissinos, A C; Mendell, G; Mercer, R A; Meshkov, S; Messenger, C; Meyer, M S; Miao, H; Miller, J; Mino, Y; Mitrofanov, V P; Mitselmakher, G; Mittleman, R; Miyakawa, O; Moe, B; Moesta, P; Mohanty, S D; Moraru, D; Moreno, G; Mossavi, K; Mow-Lowry, C M; Mueller, G; Mukherjee, S; Mullavey, A; Muller-Ebhardt, H; Munch, J; Murphy, D; Murray, P G; Nash, T; Nawrodt, R; Nelson, J; Newton, G; Nishizawa, A; Nolting, D; Nuttall, L; O'Reilly, B; O'Shaughnessy, R; Ochsner, E; O'Dell, J; Ogin, G H; Oldenburg, R G; Osthelder, C; Ott, C D; Ottaway, D J; Ottens, R S; Overmier, H; Owen, B J; Page, A; Pan, Y; Pankow, C; Papa, M A; Patel, P; Pedraza, M; Pekowsky, L; Penn, S; Peralta, C; Perreca, A; Phelps, M; Pickenpack, M; Pinto, I M; Pitkin, M; Pletsch, H J; Plissi, M V; Podkaminer, J; Pold, J; Postiglione, F; Predoi, V; Price, L R; Prijatelj, M; Principe, M; Privitera, S; Prix, R; Prokhorov, L; Puncken, O; Quetschke, V; Raab, F J; Radkins, H; Raffai, P; Rakhmanov, M; Ramet, C R; Rankins, B; Mohapatra, S R P; Raymond, V; Redwine, K; Reed, C M; Reed, T; Reid, S; Reitze, D H; Riesen, R; Riles, K; Roberts, P; Robertson, N A; Robinson, C; Robinson, E L; Roddy, S; Rollins, J; Romano, J D; Romie, J H; Rover, C; Rowan, S; Rudiger, A; Ryan, K; Sakata, S; Sakosky, M; Salemi, F; Salit, M; Sammut, L; de la Jordana, L Sancho; Sandberg, V; Sannibale, V; SantamarÌa, L; Santiago-Prieto, I; Santostasi, G; Saraf, S; Sathyaprakash, B S; Sato, S; Saulson, P R; Savage, R; Schilling, R; Schlamminger, S; Schnabel, R; Schofield, R M S; Schulz, B; Schutz, B F; Schwinberg, P; Scott, J; Scott, S M; Searle, A C; Seifert, F; Sellers, D; Sengupta, A S; Sergeev, A; Shaddock, D A; Shaltev, M; Shapiro, B; Shawhan, P; Weerathunga, T Shihan; Shoemaker, D H; Sibley, A; Siemens, X; Sigg, D; Singer, A; Singer, L; Sintes, A M; Skelton, G; Slagmolen, B J J; Slutsky, J; Smith, R; Smith, J R; Smith, M R; Smith, N D; Somiya, K; Sorazu, B; Soto, J; Speirits, F C; Stein, A J; Steinlechner, J; Steinlechner, S; Steplewski, S; Stefszky, M; Stochino, A; Stone, R; Strain, K A; Strigin, S; Stroeer, A S; Stuver, A L; Summerscales, T Z; Sung, M; Susmithan, S; Sutton, P J; Szokoly, G P; Talukder, D; Tanner, D B; Tarabrin, S P; Taylor, J R; Taylor, R; Thomas, P; Thorne, K A; Thorne, K S; Thrane, E; Thuring, A; Tokmakov, K V; Torres, C; Torrie, C I; Traylor, G; Trias, M; Tseng, K; Ugolini, D; Urbanek, K; Vahlbruch, H; Vaishnav, B; Vallisneri, M; Broeck, C Van Den; van der Sluys, M V; van Veggel, A A; Vass, S; Vaulin, R; Vecchio, A; Veitch, J; Veitch, P J; Veltkamp, C; Villar, A E; Vorvick, C; Vyachanin, S P; Waldman, S J; Wallace, L; Wanner, A; Ward, R L; Wei, P; Weinert, M; Weinstein, A J; Weiss, R; Wen, L; Wen, S; Wessels, P; West, M; Westphal, T; Wette, K; Whelan, J T; Whitcomb, S E; White, D; Whiting, B F; Wilkinson, C; Willems, P A; Williams, H R; Williams, L; Willke, B; Winkelmann, L; Winkler, W; Wipf, C C; Wiseman, A G; Woan, G; Wooley, R; Worden, J; Yablon, J; Yakushin, I; Yamamoto, K; Yamamoto, H; Yang, H; Yeaton-Massey, D; Yoshida, S; Yu, P; Zanolin, M; Zhang, L; Zhang, Z; Zhao, C; Zotov, N; Zucker, M E; Zweizig, J; Bizouard, M A; Dietz, A; Guidi, G M; Was, M

    2012-01-01

    We present the results of a LIGO search for gravitational waves (GWs) associated with GRB 051103, a short-duration hard-spectrum gamma-ray burst (GRB) whose electromagnetically determined sky position is coincident with the spiral galaxy M81, which is 3.6 Mpc from Earth. Possible progenitors for short-hard GRBs include compact object mergers and soft gamma repeater (SGR) giant flares. A merger progenitor would produce a characteristic GW signal that should be detectable at the distance of M81, while GW emission from an SGR is not expected to be detectable at that distance. We found no evidence of a GW signal associated with GRB 051103. Assuming weakly beamed gamma-ray emission with a jet semi-angle of 30 deg we exclude a binary neutron star merger in M81 as the progenitor with a confidence of 98%. Neutron star-black hole mergers are excluded with > 99% confidence. If the event occurred in M81 our findings support the the hypothesis that GRB 051103 was due to an SGR giant flare, making it the most distant extr...

  8. The 1.4 GHZ light curve of GRB 970508

    NARCIS (Netherlands)

    Galama, TJ; Wijers, RAMJ; Groot, PJ; Strom, RG; De Bruyn, AG; Kouveliotou, C; Robinson, CR; van Paradus, J

    1998-01-01

    We report on Westerbork 1.4 GHz radio observations of the radio counterpart to gamma-ray burst GRB 970508, between 0.80 and 138 days after this event. The 1.4 GHz light curve shows a transition from optically thick to thin emission between 39 and 54 days after the event. We derive the slope p of the

  9. The Supercritical Pile GRB Model: The Prompt to Afterglow Evolution

    Science.gov (United States)

    Mastichiadis, A.; Kazanas, D.

    2009-01-01

    The "Supercritical Pile" is a very economical GRB model that provides for the efficient conversion of the energy stored in the protons of a Relativistic Blast Wave (RBW) into radiation and at the same time produces - in the prompt GRB phase, even in the absence of any particle acceleration - a spectral peak at energy approx. 1 MeV. We extend this model to include the evolution of the RBW Lorentz factor Gamma and thus follow its spectral and temporal features into the early GRB afterglow stage. One of the novel features of the present treatment is the inclusion of the feedback of the GRB produced radiation on the evolution of Gamma with radius. This feedback and the presence of kinematic and dynamic thresholds in the model can be the sources of rich time evolution which we have began to explore. In particular. one can this may obtain afterglow light curves with steep decays followed by the more conventional flatter afterglow slopes, while at the same time preserving the desirable features of the model, i.e. the well defined relativistic electron source and radiative processes that produce the proper peak in the (nu)F(sub nu), spectra. In this note we present the results of a specific set of parameters of this model with emphasis on the multiwavelength prompt emission and transition to the early afterglow.

  10. Shocked by GRB 970228: the afterglow of a cosmological fireball

    NARCIS (Netherlands)

    Wijers, R.A.M.J.; Rees, M.J.; Meszaros, P.

    1997-01-01

    The location accuracy of the BeppoSAX Wide Field Cameras and acute ground-based follow-up have led to the detection of a decaying afterglow in X-rays and optical light following the classical gamma-ray burst GRB 970228. The afterglow in X-rays and optical light fades as a power law at all wavelength

  11. Physics of the GRB 030328 afterglow and its environment

    NARCIS (Netherlands)

    Maiorano, E.; Masetti, N.; Palazzi, E.; Savaglio, S.; Rol, E.; Vreeswijk, P.M.; Pian, E.; Price, P.A.; Peterson, B.A.; Jelínek, M.; Amati, L.; Andersen, M.I.; Castro-Tirado, A.J.; Castro Cerón, J.M.; de Ugarte Postigo, A.; Frontera, F.; Fruchter, A.S.; Fynbo, J.P.U.; Gorosabel, J.; Henden, A.A.; Hjorth, J.; Jensen, B.L.; Klose, S.; Kouveliotou, C.; Masi, G.; Møller, P.; Nicastro, L.; Ofek, E.O.; Pandey, S.B.; Rhoads, J.E.; Tanvir, N.R.; Wijers, R.A.M.J.; van den Heuvel, E.P.J.

    2006-01-01

    Aims.To investigate the physical nature of the afterglow emission. We report on the photometric, spectroscopic and polarimetric observations of the optical afterglow of Gamma-Ray Burst (GRB) 030328 detected by HETE-2. Methods.Photometric, spectroscopic and polarimetric monitoring of the optical afte

  12. ALMA and RATIR observations of GRB 131030A

    Science.gov (United States)

    Huang, Kuiyun; Urata, Yuji; Takahashi, Satoko; Im, Myungshin; Yu, Po-Chieh; Choi, Changsu; Butler, Nathaniel; Watson, Alan M.; Kutyrev, Alexander; Lee, William H.; Klein, Chris; Fox, Ori D.; Littlejohns, Owen; Cucchiara, Nino; Troja, Eleonora; González, Jesús; Richer, Michael G.; Román-Zúñiga, Carlos; Bloom, Josh; Prochaska, J. Xavier; Gehrels, Neil; Moseley, Harvey; Georgiev, Leonid; de Diego, José A.; Ramirez-Ruiz, Enrico

    2017-01-01

    We report on the first open-use based Atacama Large Millimeter/submm Array (ALMA) 345 GHz observation for the late afterglow phase of GRB 131030A. The ALMA observation constrained a deep limit at 17.1 d for the afterglow and host galaxy. We also identified a faint submillimeter source (ALMA J2300-0522) near the GRB 131030A position. The deep limit at 345 GHz and multifrequency observations obtained using Swift and RATIR yielded forward-shock modeling with a two-dimensional relativistic hydrodynamic jet simulation and described X-ray excess in the afterglow. The excess was inconsistent with the synchrotron self-inverse Compton radiation from the forward shock. The host galaxy of GRB 131030A and optical counterpart of ALMA J2300-0522 were also identified in the Subaru image. Based on the deep ALMA limit for the host galaxy, the 3σ upper limits of IR luminosity and the star formation rate (SFR) are estimated as LIR ALMA J2300-0522 may be one component of the GRB 131030A host galaxy, according to previous host galaxy cases.

  13. Spectroscopy of the short-hard GRB 130603B

    DEFF Research Database (Denmark)

    Postigo, A. de Ugarte; Thoene, C. C.; Rowlinson, A.;

    2014-01-01

    Short duration gamma-ray bursts (SGRBs) are thought to be related to the violent merger of compact objects, such as neutron stars or black holes, which makes them promising sources of gravitational waves. The detection of a 'kilonova'-like signature associated to the Swift-detected GRB 130603B has...

  14. Early danish GRB experiments - And some for the future?

    DEFF Research Database (Denmark)

    Lund, Niels

    2013-01-01

    by a japanese report of a balloon instrument for GRB studies based on a Rotation Modulation Collimator we at the Danish Space Research Institute started the development of an RMC detector for GRBs, the WATCH wide field monitor. Four WATCH units were flown on the Soviet Granat satellites, and one on ESA's EURECA...

  15. WIDGET: System Performance and GRB Prompt Optical Observations

    CERN Document Server

    Urata, Yuji; Tamagawa, Toru; Usui, Fumihiko; Kuwahara, Makoto; Lin, Hungmiao; Kageyama, Shoichi; Iwakiri, Wataru; Sugasahara, Takako; Takahara, Kazuki; Kodaka, Natsuki; Abe, Keiichi; Masuno, Keisuke; Onda, Kaori

    2010-01-01

    The WIDeField telescope for Gamma-ray burst Early Timing (WIDGET) is used for a fully automated, ultra-wide-field survey aimed at detecting the prompt optical emission associated with Gamma-ray Bursts (GRBs). WIDGET surveys the HETE-2 and Swift/BAT pointing directions covering a total field of view of 62 degree x 62 degree every 10 secounds using an unfiltered system. This monitoring survey allows exploration of the optical emission before the gamma-ray trigger. The unfiltered magnitude is well converted to the SDSS r' system at a 0.1 mag level. Since 2004, WIDGET has made a total of ten simultaneous and one pre-trigger GRB observations. The efficiency of synchronized observation with HETE-2 is four times better than that of Swift. There has been no bright optical emission similar to that from GRB 080319B. The statistical analysis implies that GRB080319B is a rare event. This paper summarizes the design and operation of the WIDGET system and the simultaneous GRB observations obtained with this instrument.

  16. LOTIS Upper Limits and the Prompt OT from GRB 990123

    Energy Technology Data Exchange (ETDEWEB)

    Williams, G G; Hartmann, D H; Park, H S; Porrata, R A; Ables, E; Bionta, R; Band, D L; Barthelmy, S D; Cline, T; Gehrels, N; Ferguson, D H; Fishman, G; Kippen, R M; Kouveliotou, C; Hurley, K; Nemiroff, R; Sasseen, T

    2000-08-10

    GRB 990123 established the existence of prompt optical emission from gamma-ray bursts (GRBs). The Livermore Optical Transient Imaging System (LOTIS) has been conducting a fully automated search for this kind of simultaneous low energy emission from GRBs since October 1996. Although LOTIS has obtained simultaneous, or near simultaneous, coverage of the error boxes obtained with BATSE, IPN, XTE, and BeppoSAX for several GRBs, image analysis resulted in only upper limits. The unique gamma-ray properties of GRB 990123, such as very large fluence (top 0.4%) and hard spectrum, complicate comparisons with more typical bursts. We scale and compare gamma-ray properties, and in some cases afterglow properties, from the best LOTIS events to those of GRB 990123 in an attempt to determine whether the prompt optical emission of this event is representative of all GRBs. Furthermore, using LOTIS upper limits in conjunction with the relativistic blast wave model, we weakly constrain the GRB and afterglow parameters such as density of the circumburster medium and bulk Lorentz factor of the ejecta.

  17. The Redshift of the Optical Transient Associated with GRB 010222

    CERN Document Server

    Jha, S; Garnavich, P M; Calkins, M L; Kilgard, R E; Matheson, T; McDowell, J C; Roll, J B; Stanek, K Z; Jha, Saurabh; Pahre, Michael A.; Garnavich, Peter M.; Calkins, Michael L.; Kilgard, Roy E.; Matheson, Thomas; Dowell, Jonathan C. Mc; Roll, John B.; Stanek, Krzysztof Z.

    2001-01-01

    The gamma-ray burst (GRB) 010222 is the brightest GRB detected to date by the BeppoSAX satellite. Prompt identification of the associated optical transient (OT) allowed for spectroscopy with the Tillinghast 1.5m telescope at F. L. Whipple Observatory while the source was still relatively bright (R ~ 18.6 mag), within five hours of the burst. The OT shows a blue continuum with many superimposed absorption features corresponding to metal lines at z = 1.477, 1.157, and possibly also at 0.928. The redshift of GRB 010222 is therefore unambiguously placed at z >= 1.477. The high number of Mg II absorbers and especially the large equivalent widths of the Mg II, Mg I, and Fe II absorption lines in the z = 1.477 system further argue either for a very small impact parameter or that the z = 1.477 system is the GRB host galaxy itself. The spectral index of the OT is relatively steep, beta = 0.89 +/- 0.03, and this cannot be caused by dust with a standard Galactic extinction law in the z = 1.477 absorption system. This sp...

  18. Spectroscopy of the short-hard GRB 130603B

    DEFF Research Database (Denmark)

    Postigo, A. de Ugarte; Thoene, C. C.; Rowlinson, A.

    2014-01-01

    Short duration gamma-ray bursts (SGRBs) are thought to be related to the violent merger of compact objects, such as neutron stars or black holes, which makes them promising sources of gravitational waves. The detection of a 'kilonova'-like signature associated to the Swift-detected GRB 130603B has...

  19. Constraints on Very High Energy Emission from GRB 130427A

    CERN Document Server

    Aliu, E; Barnacka, A; Beilicke, M; Benbow, W; Berger, K; Biteau, J; Buckley, J H; Bugaev, V; Byrum, K; Cardenzana, J V; Cerruti, M; Chen, X; Ciupik, L; Connaughton, V; Cui, W; Dickinson, H J; Eisch, J D; Errando, M; Falcone, A; Federici, S; Feng, Q; Finley, J P; Fleischhack, H; Fortin, P; Fortson, L; Furniss, A; Galante, N; Gillanders, G H; Griffin, S; Griffiths, S T; Grube, J; Gyuk, G; Håkansson, N; Hanna, D; Holder, J; Hughes, G; Humensky, T B; Johnson, C A; Kaaret, P; Kar, P; Kertzman, M; Khassen, Y; Kieda, D; Krawczynski, H; Krennrich, F; Lang, M J; Madhavan, A S; Maier, G; McArthur, S; McCann, A; Meagher, K; Millis, J; Moriarty, P; Mukherjee, R; Nieto, D; de Bhróithe, A O'Faoláin; Ong, R A; Otte, A N; Park, N; Pohl, M; Popkow, A; Prokoph, H; Pueschel, E; Quinn, J; Ragan, K; Rajotte, J; Reyes, L C; Reynolds, P T; Richards, G T; Roache, E; Sembroski, G H; Shahinyan, K; Smith, A W; Staszak, D; Telezhinsky, I; Tucci, J V; Tyler, J; Varlotta, A; Vassiliev, V V; Vincent, S; Wakely, S P; Weiner, O M; Weinstein, A; Welsing, R; Wilhelm, A; Williams, D A; Zitzer, B; McEnery, J E; Perkins, J S; Veres, P; Zhu, S

    2014-01-01

    Prompt emission from the very fluent and nearby (z=0.34) gamma-ray burst GRB 130427A was detected by several orbiting telescopes and by ground-based, wide-field-of-view optical transient monitors. Apart from the intensity and proximity of this GRB, it is exceptional due to the extremely long-lived high-energy (100 MeV to 100 GeV) gamma-ray emission, which was detected by the Large Area Telescope on the Fermi Gamma-ray Space Telescope for ~70 ks after the initial burst. The persistent, hard-spectrum, high-energy emission suggests that the highest-energy gamma rays may have been produced via synchrotron self-Compton processes though there is also evidence that the high-energy emission may instead be an extension of the synchrotron spectrum. VERITAS, a ground-based imaging atmospheric Cherenkov telescope array, began follow-up observations of GRB 130427A ~71 ks (~20 hr) after the onset of the burst. The GRB was not detected with VERITAS; however, the high elevation of the observations, coupled with the low redsh...

  20. Implications for the Origin of GRB 051103 from LIGO Observations

    Science.gov (United States)

    Abadie, J.; Abbott, B. P.; Abbott, T. D.; Abbott, R.; Abernathy, M.; Adams, C.; Adhikari, R.; Affeldt, C.; Ajith, P.; Allen, B.; Allen, G. S.; Amador Ceron, E.; Amariutei, D.; Amin, R. S.; Anderson, S. B.; Anderson, W. G.; Arai, K.; Arain, M. A.; Araya, M. C.; Aston, S. M.; Atkinson, D.; Aufmuth, P.; Aulbert, C.; Aylott, B. E.; Babak, S.; Baker, P.; Ballmer, S.; Barker, D.; Barnum, S.; Barr, B.; Barriga, P.; Barsotti, L.; Barton, M. A.; Bartos, I.; Bassiri, R.; Bastarrika, M.; Bauchrowitz, J.; Behnke, B.; Bell, A. S.; Belopolski, I.; Benacquista, M.; Bertolini, A.; Betzwieser, J.; Beveridge, N.; Beyersdorf, P. T.; Bilenko, I. A.; Billingsley, G.; Birch, J.; Biswas, R.; Black, E.; Blackburn, J. K.; Blackburn, L.; Blair, D.; Bland, B.; Bock, O.; Bodiya, T. P.; Bogan, C.; Bondarescu, R.; Bork, R.; Born, M.; Bose, S.; Boyle, M.; Brady, P. R.; Braginsky, V. B.; Brau, J. E.; Breyer, J.; Bridges, D. O.; Brinkmann, M.; Britzger, M.; Brooks, A. F.; Brown, D. A.; Brummitt, A.; Buonanno, A.; Burguet-Castell, J.; Burmeister, O.; Byer, R. L.; Cadonati, L.; Camp, J. B.; Campsie, P.; Cannizzo, J.; Cannon, K.; Cao, J.; Capano, C.; Caride, S.; Caudill, S.; Cavaglia, M.; Cepeda, C.; Chalermsongsak, T.; Chalkley, E.; Charlton, P.; Chelkowski, S.; Chen, Y.; Christensen, N.; Chua, S. S. Y.; Chung, S.; Chung, C. T. Y.; Clara, F.; Clark, D.; Clark, J.; Clayton, J. H.; Conte, R.; Cook, D.; Corbitt, T. R. C.; Cornish, N.; Costa, C. A.; Coughlin, M.; Coward, D. M.; Coyne, D. C.; Creighton, J. D. E.; Creighton, T. D.; Cruise, A. M.; Cumming, A.; Cunningham, L.; Culter, R. M.; Dahl, K.; Danilishin, S. L.; Dannenberg, R.; Danzmann, K.; Das, K.; Daudert, B.; Daveloza, H.; Davies, G.; Daw, E. J.; Dayanga, T.; DeBra, D.; Degallaix, J.; Dent, T.; Dergachev, V.; DeRosa, R.; DeSalvo, R.; Dhurandhar, S.; Di Palma, I.; Díaz, M.; Donovan, F.; Dooley, K. L.; Dorsher, S.; Douglas, E. S. D.; Drever, R. W. P.; Driggers, J. C.; Dumas, J.-C.; Dwyer, S.; Eberle, T.; Edgar, M.; Edwards, M.; Effler, A.; Ehrens, P.; Engel, R.; Etzel, T.; Evans, M.; Evans, T.; Factourovich, M.; Fairhurst, S.; Fan, Y.; Farr, B. F.; Fazi, D.; Fehrmann, H.; Feldbaum, D.; Finn, L. S.; Flanigan, M.; Foley, S.; Forsi, E.; Fotopoulos, N.; Frede, M.; Frei, M.; Frei, Z.; Freise, A.; Frey, R.; Fricke, T. T.; Friedrich, D.; Fritschel, P.; Frolov, V. V.; Fulda, P.; Fyffe, M.; Garcia, J.; Garofoli, J. A.; Gholami, I.; Ghosh, S.; Giaime, J. A.; Giampanis, S.; Giardina, K. D.; Gill, C.; Goetz, E.; Goggin, L. M.; González, G.; Gorodetsky, M. L.; Goßler, S.; Graef, C.; Grant, A.; Gras, S.; Gray, C.; Greenhalgh, R. J. S.; Gretarsson, A. M.; Grosso, R.; Grote, H.; Grunewald, S.; Guido, C.; Gupta, R.; Gustafson, E. K.; Gustafson, R.; Hage, B.; Hallam, J. M.; Hammer, D.; Hammond, G.; Hanks, J.; Hanna, C.; Hanson, J.; Harms, J.; Harry, G. M.; Harry, I. W.; Harstad, E. D.; Hartman, M. T.; Haughian, K.; Hayama, K.; Heefner, J.; Hendry, M. A.; Heng, I. S.; Heptonstall, A. W.; Herrera, V.; Hewitson, M.; Hild, S.; Hoak, D.; Hodge, K. A.; Holt, K.; Hong, T.; Hooper, S.; Hosken, D. J.; Hough, J.; Howell, E. J.; Hughey, B.; Husa, S.; Huttner, S. H.; Ingram, D. R.; Inta, R.; Isogai, T.; Ivanov, A.; Johnson, W. W.; Jones, D. I.; Jones, G.; Jones, R.; Ju, L.; Kalmus, P.; Kalogera, V.; Kandhasamy, S.; Kanner, J. B.; Katsavounidis, E.; Katzman, W.; Kawabe, K.; Kawamura, S.; Kawazoe, F.; Kells, W.; Kelner, M.; Keppel, D. G.; Khalaidovski, A.; Khalili, F. Y.; Khazanov, E. A.; Kim, N.; Kim, H.; King, P. J.; Kinzel, D. L.; Kissel, J. S.; Klimenko, S.; Kondrashov, V.; Kopparapu, R.; Koranda, S.; Korth, W. Z.; Kozak, D.; Kringel, V.; Krishnamurthy, S.; Krishnan, B.; Kuehn, G.; Kumar, R.; Kwee, P.; Landry, M.; Lantz, B.; Lastzka, N.; Lazzarini, A.; Leaci, P.; Leong, J.; Leonor, I.; Li, J.; Lindquist, P. E.; Lockerbie, N. A.; Lodhia, D.; Lormand, M.; Lu, P.; Luan, J.; Lubinski, M.; Lück, H.; Lundgren, A. P.; Macdonald, E.; Machenschalk, B.; MacInnis, M.; Mageswaran, M.; Mailand, K.; Mandel, I.; Mandic, V.; Marandi, A.; Márka, S.; Márka, Z.; Maros, E.; Martin, I. W.; Martin, R. M.; Marx, J. N.; Mason, K.; Matichard, F.; Matone, L.; Matzner, R. A.; Mavalvala, N.; McCarthy, R.; McClelland, D. E.; McGuire, S. C.; McIntyre, G.; McIver, J.; McKechan, D. J. A.; Meadors, G.; Mehmet, M.; Meier, T.; Melatos, A.; Melissinos, A. C.; Mendell, G.; Mercer, R. A.; Meshkov, S.; Messenger, C.; Meyer, M. S.; Miao, H.; Miller, J.; Mino, Y.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Miyakawa, O.; Moe, B.; Moesta, P.; Mohanty, S. D.; Moraru, D.; Moreno, G.; Mossavi, K.; Mow-Lowry, C. M.; Mueller, G.; Mukherjee, S.; Mullavey, A.; Müller-Ebhardt, H.; Munch, J.; Murphy, D.; Murray, P. G.; Nash, T.; Nawrodt, R.; Nelson, J.; Newton, G.; Nishizawa, A.; Nolting, D.; Nuttall, L.; O'Reilly, B.; O'Shaughnessy, R.; Ochsner, E.; O'Dell, J.

    2012-08-01

    We present the results of a LIGO search for gravitational waves (GWs) associated with GRB 051103, a short-duration hard-spectrum gamma-ray burst (GRB) whose electromagnetically determined sky position is coincident with the spiral galaxy M81, which is 3.6 Mpc from Earth. Possible progenitors for short-hard GRBs include compact object mergers and soft gamma repeater (SGR) giant flares. A merger progenitor would produce a characteristic GW signal that should be detectable at a distance of M81, while GW emission from an SGR is not expected to be detectable at that distance. We found no evidence of a GW signal associated with GRB 051103. Assuming weakly beamed γ-ray emission with a jet semi-angle of 30°, we exclude a binary neutron star merger in M81 as the progenitor with a confidence of 98%. Neutron star-black hole mergers are excluded with >99% confidence. If the event occurred in M81, then our findings support the hypothesis that GRB 051103 was due to an SGR giant flare, making it one of the most distant extragalactic magnetars observed to date.

  1. An External Shock Origin of GRB $\\textit{141028A}$

    CERN Document Server

    Burgess, J Michael; Ryde, Felix; Omodei, Nicola; Pe'er, Asaf; Racusin, J L; Cucchiara, A

    2015-01-01

    The prompt emission of the long, smooth, and single-pulsed gamma-ray burst, GRB $\\textit{141028A}$, is analyzed under the guise of an external shock model. First, we fit the $\\gamma$-ray spectrum with a two-component photon model, namely synchrotron+blackbody, and then fit the recovered evolution of the synchrotron $\

  2. CONSTRAINTS ON THE EMISSION MODEL OF THE 'NAKED-EYE BURST' GRB 080319B

    Energy Technology Data Exchange (ETDEWEB)

    Abdo, A. A.; Abeysekara, A. U.; Linnemann, J. T. [Department of Physics and Astronomy, Michigan State University, 3245 BioMedical Physical Sciences Building, East Lansing, MI 48824 (United States); Allen, B. T.; Chen, C. [Department of Physics and Astronomy, University of California, Irvine, CA 92697 (United States); Aune, T. [Santa Cruz Institute for Particle Physics, University of California, 1156 High Street, Santa Cruz, CA 95064 (United States); Berley, D.; Goodman, J. A. [Department of Physics, University of Maryland, College Park, MD 20742 (United States); Christopher, G. E.; Kolterman, B. E.; Mincer, A. I. [Department of Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); DeYoung, T. [Department of Physics, Pennsylvania State University, University Park, PA 16802 (United States); Dingus, B. L.; Hoffman, C. M. [Group P-23, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545 (United States); Ellsworth, R. W. [School of Physics, Astronomy and Computational Sciences, George Mason University, Fairfax, VA 22030 (United States); Gonzalez, M. M. [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, D.F., Mexico 04510 (Mexico); Granot, J. [Open University of Israel, 1 University Road, POB 808, Ra' anana 43537 (Israel); Hays, E.; McEnery, J. E. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Huentemeyer, P. H. [Department of Physics, Michigan Technological University, Houghton, MI 49931 (United States); and others

    2012-07-10

    On 2008 March 19, one of the brightest gamma-ray bursts (GRBs) ever recorded was detected by several ground- and space-based instruments spanning the electromagnetic spectrum from radio to gamma rays. With a peak visual magnitude of 5.3, GRB 080319B was dubbed the 'naked-eye' GRB, as an observer under dark skies could have seen the burst without the aid of an instrument. Presented here are results from observations of the prompt phase of GRB 080319B taken with the Milagro TeV observatory. The burst was observed at an elevation angle of 47 Degree-Sign . Analysis of the data is performed using both the standard air shower method and the scaler or single-particle technique, which results in a sensitive energy range that extends from {approx}5 GeV to >20 TeV. These observations provide the only direct constraints on the properties of the high-energy gamma-ray emission from GRB 080319B at these energies. No evidence for emission is found in the Milagro data, and upper limits on the gamma-ray flux above 10 GeV are derived. The limits on emission between {approx}25 and 200 GeV are incompatible with the synchrotron self-Compton model of gamma-ray production and disfavor a corresponding range (2 eV-16 eV) of assumed synchrotron peak energies. This indicates that the optical photons and soft ({approx}650 keV) gamma rays may not be produced by the same electron population.

  3. Development of a differential interference contrast thermal lens microscope for sensitive individual nanoparticle detection in liquid.

    Science.gov (United States)

    Shimizu, Hisashi; Mawatari, Kazuma; Kitamori, Takehiko

    2009-12-01

    A thermal lens microscope (TLM) with a new principle was developed to improve the detection limit of conventional TLM. The detection limit was decreased by introducing a differential interference contrast (DIC) method which realizes background-free photodetection. The new differential interference contrast thermal lens microscope (DIC-TLM) exploits phase contrast resulting from a photothermal effect instead of refraction used in conventional TLM. In order to produce high phase contrast, we fabricated a pair of DIC prisms with a large shear value of 5 microm which is in accordance with the thermal diffusion length. First, we verified the principle of DIC-TLM. The background of TLM measurement was reduced to 1/100 by differential interference, and the signal-to-background (S/B) ratio was improved by 1 order of magnitude. The signal was confirmed to originate from phase contrast, and the expansion of the shear value was effective. Furthermore, we demonstrated counting of individual gold nanoparticles (5 nm) using DIC-TLM. The particles were counted with high signal-to-noise (S/N) ratio, and the S/N ratio was improved by 1 order of magnitude. Finally, we discuss the possibility of single molecule counting in a liquid.

  4. Combined effects of irritants and allergens. Synergistic effects of nickel and sodium lauryl sulfate in nickel- sensitized individuals

    DEFF Research Database (Denmark)

    Agner, Tove; Johansen, Jeanne Duus; Overgaard, Lene

    2002-01-01

    Knowledge of the combined effects of irritants and allergens is of interest with respect to accurate risk assessment. The threshold for elicitation of allergic contact dermatitis in previously sensitized individuals may theoretically be markedly influenced by the simultaneous presence of irritants...... exposure to NiCl2 and SLS, as compared to each of the substances applied separately, as evaluated by colorimetry and clinical scoring. This means that the effect produced by the combined exposure was substantially greater than the effect produced by either of the substances alone. A synergistic effect...

  5. A magnetar powering the ordinary monster GRB 130427A?

    Science.gov (United States)

    Bernardini, M. G.; Campana, S.; Ghisellini, G.; D'Avanzo, P.; Calderone, G.; Covino, S.; Cusumano, G.; Ghirlanda, G.; La Parola, V.; Maselli, A.; Melandri, A.; Salvaterra, R.; Burlon, D.; D'Elia, V.; Fugazza, D.; Sbarufatti, B.; Vergani, S. D.; Tagliaferri, G.

    2014-03-01

    We present the analysis of the extraordinarily bright gamma-ray burst (GRB) 130427A under the hypothesis that the GRB central engine is an accretion-powered magnetar. In this framework, initially proposed to explain GRBs with precursor activity, the prompt emission is produced by accretion of matter on to a newly born magnetar, and the observed power is related to the accretion rate. The emission is eventually halted if the centrifugal forces are able to pause accretion. We show that the X-ray and optical afterglow is well explained as the forward shock emission with a jet break plus a contribution from the spin-down of the magnetar. Our modelling does not require any contribution from the reverse shock, that may still influence the afterglow light curve at radio and mm frequencies, or in the optical at early times. We derive the magnetic field (B ˜ 1016 G) and the spin period (P ˜ 20 ms) of the magnetar and obtain an independent estimate of the minimum luminosity for accretion. This minimum luminosity results well below the prompt emission luminosity of GRB 130427A, providing a strong consistency check for the scenario where the entire prompt emission is the result of continuous accretion on to the magnetar. This is in agreement with the relatively long spin period of the magnetar. GRB 130427A was a well-monitored GRB showing a very standard behaviour and, thus, is a well-suited benchmark to show that an accretion-powered magnetar gives a unique view of the properties of long GRBs.

  6. Study of GRB light curve decay indices in the afterglow phase

    CERN Document Server

    Del Vecchio, Roberta; Ostrowski, Michał

    2016-01-01

    In this work we study the distribution of temporal power-law decay indices, $\\alpha$, in the Gamma Ray Burst (GRB) afterglow phase, fitted for $176$ GRBs (139 long GRBs, 12 short GRBs {\\it with extended emission} and 25 X-Ray Flashes (XRFs)) with known redshifts. These indices are compared to the values of characteristic afterglow luminosity, $L_a$, the time, $T_a^*$, and the decay index, $\\alpha_W$, derived with global light curve fitting using the \\cite{willingale07} model. This model fitting yields similar distributions of $\\alpha_W$ to the fitted $\\alpha$, but for individual bursts a difference can be significant. Analysis of the ($\\alpha$, $L_a$) distribution reveals only a weak correlation of these quantities. However, we discovered a significant regular trend when studying GRB $\\alpha$ values along the $L_a$ versus $T_a^*$ (LT) distribution, with systematic variation of $\\alpha$ parameter distribution with luminosity for any selected $T_a^*$. We analyze this systematics with respect to the fitted LT co...

  7. GRB 090510: a genuine short-GRB from a binary neutron star coalescing into a Kerr-Newman black hole

    CERN Document Server

    Enderli, M; Muccino, M; Aimuratov, Y; Bianco, C L; Cherubini, C; Kovacevic, M; Moradi, R; Penacchioni, A V; Pisani, G B; Rueda, J A; Wang, Y

    2016-01-01

    In a new classification of merging binary neutron stars (NSs) we separate short gamma-ray bursts (GRBs) in two sub-classes. The ones with $E_{\\rm iso}\\lesssim10^{52}$ erg coalesce to form a massive NS and are indicated as short gamma-ray flashes (S-GRFs). The hardest, with $E_{\\rm iso}\\gtrsim10^{52}$ erg, coalesce to form a black hole (BH) and are indicated as genuine short-GRBs (S-GRBs). Within the fireshell model, S-GRBs exhibit three different components: the P-GRB emission, observed at the transparency of a self-accelerating baryon-$e^+e^-$ plasma; the prompt emission, originating from the interaction of the accelerated baryons with the circumburst medium; the high-energy (GeV) emission, observed after the P-GRB and indicating the formation of a BH. GRB 090510 gives the first evidence for the formation of a Kerr-Newman BH. Its P-GRB spectrum can be fitted by a convolution of thermal spectra whose origin can be traced back to an axially symmetric dyadotorus. A large value of the angular momentum of the new...

  8. Long-short GRBs within the horizon of the advanced LIGO/VIRGO network and Time lag between compact object coalescence and GRB onset

    CERN Document Server

    Li, Xiang; Fan, Yi-Zhong; Wei, Da-Ming

    2016-01-01

    Short duration GRBs (SGRBs) are widely believed to be powered by the mergers of compact binaries, like binary neutron stars or possibly neutron star-black hole binaries. Though the prospect of detecting SGRBs with gravitational wave (GW) signals by the advanced LIGO/VIRGO network is promising, no known SGRB has been found within the expected advanced LIGO/VIRGO sensitivity range. We argue, however, that the two long-short GRBs (GRB 060505 and GRB 060614) may be within the horizon of advanced GW detectors. In the upcoming era of GW astronomy, the merger origin of some long-short GRBs, as favored by the macronova signature displayed in GRB 060614, can be unambiguously tested. The model-dependent time-lags between the merger and the onset of the prompt emission of GRB are estimated. The comparison of such time-lags between model prediction to the real data expected in the era of the GW astronomy would be helpful in revealing the physical processes taking place at the central engine (including the launch of the r...

  9. The properties of the 2175AA extinction feature discovered in GRB afterglows

    CERN Document Server

    Zafar, Tayyaba; Eliasdottir, Ardis; Fynbo, Johan P U; Kruhler, Thomas; Schady, Patricia; Leloudas, Giorgos; Jakobsson, Pall; Thone, Christina C; Perley, Daniel A; Morgan, Adam N; Bloom, Joshua; Greiner, Jochen

    2012-01-01

    The unequivocal, spectroscopic detection of the 2175 bump in extinction curves outside the Local Group is rare. To date, the properties of the bump have been examined in only two GRB afterglows (GRB 070802 and GRB 080607). In this work we analyse in detail the detections of the 2175 extinction bump in the optical spectra of the two further GRB afterglows: GRB 080605 and 080805. We gather all available optical/NIR photometric, spectroscopic and X-ray data to construct multi-epoch SEDs for both GRB afterglows. We fit the SEDs with the Fitzpatrick & Massa (1990) model with a single or broken PL. We also fit a sample of 38 GRB afterglows, known to prefer a SMC-type extinction curve, with the same model. We find that the SEDs of GRB 080605 and GRB 080805 at two epochs are fit well with a single PL with a derived extinction of A_V = 0.52(+0.13 -0.16) and 0.50 (+0.13 -0.10), and 2.1(+0.7-0.6) and 1.5+/-0.2 respectively. While the slope of the extinction curve of GRB 080805 is not well-constrained, the extinction...

  10. Distrust as a Disease-Avoidance Strategy:Individual Differences in Disgust Sensitivity Regulate Generalized Social Trust

    Directory of Open Access Journals (Sweden)

    Lene Aarøe

    2016-07-01

    Full Text Available Throughout human evolutionary history, cooperative contact with others has been fundamental for human survival. At the same time, social contact has been a source of threats. In this article, we focus on one particular viable threat, communicable disease, and investigate how motivations to avoid pathogens influence people's propensity to interact and cooperate with others, as measured by individual differences in generalized social trust. While extant studies on pathogen avoidance have argued that such motivations should prompt people to avoid interactions with outgroups specifically, we argue that these motivations should prompt people to avoid others more broadly. Empirically, we utilise two convenience samples and a large nationally representative sample of US citizens to demonstrate the existence of a robust and replicable effect of individual differences in pathogen disgust sensitivity on generalized social trust. We furthermore compare the effects of pathogen disgust sensitivity on generalised social trust and outgroup prejudice and explore whether generalised social trust to some extent constitutes a pathway between pathogen avoidance motivations and prejudice.

  11. Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells.

    Science.gov (United States)

    Hammarstedt, Ann; Graham, Timothy E; Kahn, Barbara B

    2012-09-19

    Obesity contributes to Type 2 diabetes by promoting systemic insulin resistance. Obesity causes features of metabolic dysfunction in the adipose tissue that may contribute to later impairments of insulin action in skeletal muscle and liver; these include reduced insulin-stimulated glucose transport, reduced expression of GLUT4, altered expression of adipokines, and adipocyte hypertrophy. Animal studies have shown that expansion of adipose tissue alone is not sufficient to cause systemic insulin resistance in the absence of adipose tissue metabolic dysfunction. To determine if this holds true for humans, we studied the relationship between insulin resistance and markers of adipose tissue dysfunction in non-obese individuals. 32 non-obese first-degree relatives of Type 2 diabetic patients were recruited. Glucose tolerance was determined by an oral glucose tolerance test and insulin sensitivity was measured with the hyperinsulinaemic-euglycaemic clamp. Blood samples were collected and subcutaneous abdominal adipose tissue biopsies obtained for gene/protein expression and adipocyte cell size measurements. Our findings show that also in non-obese individuals low insulin sensitivity is associated with signs of adipose tissue metabolic dysfunction characterized by low expression of GLUT4, altered adipokine profile and enlarged adipocyte cell size. In this group, insulin sensitivity is positively correlated to GLUT4 mRNA (R = 0.49, p = 0.011) and protein (R = 0.51, p = 0.004) expression, as well as with circulating adiponectin levels (R = 0.46, 0 = 0.009). In addition, insulin sensitivity is inversely correlated to circulating RBP4 (R = -0.61, 0 = 0.003) and adipocyte cell size (R = -0.40, p = 0.022). Furthermore, these features are inter-correlated and also associated with other clinical features of the metabolic syndrome in the absence of obesity. No association could be found between the hypertrophy-associated adipocyte

  12. Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells

    Directory of Open Access Journals (Sweden)

    Hammarstedt Ann

    2012-09-01

    Full Text Available Abstract Background Obesity contributes to Type 2 diabetes by promoting systemic insulin resistance. Obesity causes features of metabolic dysfunction in the adipose tissue that may contribute to later impairments of insulin action in skeletal muscle and liver; these include reduced insulin-stimulated glucose transport, reduced expression of GLUT4, altered expression of adipokines, and adipocyte hypertrophy. Animal studies have shown that expansion of adipose tissue alone is not sufficient to cause systemic insulin resistance in the absence of adipose tissue metabolic dysfunction. To determine if this holds true for humans, we studied the relationship between insulin resistance and markers of adipose tissue dysfunction in non-obese individuals. Method 32 non-obese first-degree relatives of Type 2 diabetic patients were recruited. Glucose tolerance was determined by an oral glucose tolerance test and insulin sensitivity was measured with the hyperinsulinaemic-euglycaemic clamp. Blood samples were collected and subcutaneous abdominal adipose tissue biopsies obtained for gene/protein expression and adipocyte cell size measurements. Results Our findings show that also in non-obese individuals low insulin sensitivity is associated with signs of adipose tissue metabolic dysfunction characterized by low expression of GLUT4, altered adipokine profile and enlarged adipocyte cell size. In this group, insulin sensitivity is positively correlated to GLUT4 mRNA (R = 0.49, p = 0.011 and protein (R = 0.51, p = 0.004 expression, as well as with circulating adiponectin levels (R = 0.46, 0 = 0.009. In addition, insulin sensitivity is inversely correlated to circulating RBP4 (R = −0.61, 0 = 0.003 and adipocyte cell size (R = −0.40, p = 0.022. Furthermore, these features are inter-correlated and also associated with other clinical features of the metabolic syndrome in the absence of obesity. No association could be found

  13. Multiparametric assessment of radiation effects for the individual radiation sensitivity estimation; Multiparametrische Erfassung von Strahlenwirkungen zur Abschaetzung der individuellen Strahlenempfindlichkeit

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The effects of low dose irradiation are highly relevant for radiation protection in the public. The sensitivity to clastogenic and tumorigenic effects of ionizing radiation (IR) varies considerably amongst individuals. Examples for genetically determined enhanced sensitivity are well known in some hereditary diseases: patients with chromosomal instability syndromes, Ataxia telangiectasia (A-T), Nijmegen Breakage Syndrome (NBS) and Bloom Syndrome (BS) show strongly enhanced sensitivity towards IR, severe immunodeficiencies, and a high incidence for developing leukemias and lymphomas. This obvious coincidence of enhanced radiosensitivity and tumor risk, and the frequently observed enhanced radiosensitivity of genetically non-defined tumor patients indicate that tumor patients may constitute a subpopulation with enriched genetical predisposition for enhanced radiosensitivity. Furthermore, a subpopulation of radiosensitive individuals may be part of the probably inconspicuous total population. For example, individuals heterozygous for the above mentioned genes (and possibly some other genes) show enhanced radiosensitivity if compared with the normal population. In general, heterozygous carriers of those hereditary deficiencies are clinically inconspicuous, but due an haploinsufficiency their tumour risk may be enhanced. This has been shown for mice carrying an heterozygous Nbs1 mutation (J.-Q. Wang, Lyon, pers. Communication). Our findings concerning enhanced radiation-induced chromosomal aberrations in heterozygous Nbs1 cell lines support this notion. The identification of high risk groups with enhanced radiosensitivity is therefore an important task for radioprotection. This project aimed at establishing a procedure which allows to test various cellular parameters as indicators for effects of radiation. A standard protocol for the isolation and cryoconservation of primary blood cells was developed. DNA repair analysis (Comet Assay) and radiation-induced apoptosis

  14. Relations between pure dietary and dietary-negative affect subtypes and impulsivity and reinforcement sensitivity in binge eating individuals.

    Science.gov (United States)

    Carrard, Isabelle; Crépin, Christelle; Ceschi, Grazia; Golay, Alain; Van der Linden, Martial

    2012-01-01

    To investigate potential predictors of the severity of binge eating disorder (BED), two subtypes of patients with the disorder, a pure dietary subtype and a dietary-negative affect subtype, were identified. This study investigated the relationships between the two subtypes and impulsivity and reinforcement sensitivity. Ninety-two women meeting threshold and subthreshold criteria for BED diagnosis filled out questionnaires to determine eating disorder severity, impulsivity and reinforcement sensitivity before and after participating in an online guided self-help program for BED. Cluster analyses revealed a pure dietary subtype (N=66, 71.7%) and a dietary-negative affect subtype (N=26, 28.3%). Compared to the pure dietary subtype, the dietary-negative affect subtype reported a higher frequency of objective binge episodes, more severe eating disorders, higher urgency scores (defined as a tendency to act rashly in the context of negative affect), a greater sensitivity to punishment, and a higher dropout rate during treatment. These findings suggest that BED patients in the dietary-negative affect subtype exhibit heightened anxiety and are highly impulsive, especially in contexts of negative affect. For these individuals, psychological interventions for BED should focus on inhibiting automatic responses to negative emotions.

  15. The Remarkable Afterglow of GRB 061007: Implications for Optical Flashes and GRB Fireballs

    CERN Document Server

    Mundell, C G; Guidorzi, C; Kobayashi, S; Steele, I A; Malesani, D; Amati, L; D'Avanzo, P; Bersier, D F; Gomboc, A; Rol, E; Bode, M F; Carter, D; Mottram, C J; Monfardini, A; Smith, R J; Malhotra, S; Wang, J; Bannister, N; O'Brien, P T; Tanvir, N R

    2006-01-01

    We present a multiwavelength analysis of Swift GRB 061007. The 2-m robotic Faulkes Telescope South (FTS) began observing 137 s after the onset of the gamma-ray emission, when the optical counterpart was already decaying from R~10.3 mag, and continued observing for the next 5.5 hours. These observations begin during the final gamma-ray flare and continue through and beyond a long, soft tail of gamma-ray emission whose flux shows an underlying simple power law decay identical to that seen at optical and X-ray wavelengths, with temporal slope alpha~1.7. This remarkably simple decay in all of these bands is rare for Swift bursts, which often show much more complex light curves. We suggest the afterglow emission begins as early as 30-100 s and is contemporaneous with the on-going variable prompt emission from the central engine, but originates from a physically distinct region dominated by the forward shock. The afterglow continues unabated until at least ~10^5 seconds showing no evidence of a break. The observed ...

  16. Probing GRB environments with time variability: ULTRASPEC fast imaging of GRB 080210

    CERN Document Server

    De Cia, A; Björnsson, G; Vreeswijk, P M; Dhillon, V S; Marsh, T R; Chapman, R; Fynbo, J P U; Ledoux, C; Littlefair, S P; Malesani, D; Schulze, S; Smette, A; Zafar, T; Gudmundsson, E H

    2010-01-01

    We present high time resolution (1.09 s) photometry of GRB 080210 obtained with ULTRASPEC mounted on the ESO/3.6-m telescope, starting 68.22 min after the burst and lasting for 26.45 min. The light curve is smooth on both short (down to 2.18 s) and long time scales, confirmed by a featureless power spectrum. On top of the fireball power-law decay, bumps and wiggles at different time scales can, in principle, be produced by density fluctuations in the circumburst medium, substructures in the jet or by refreshed shocks. Comparing our constraints with variability limits derived from kinematic arguments, we exclude under-density fluctuations producing flux dips larger than 1 per cent with time scales \\Deltat > 9.2 min (2 per cent on \\Deltat > 2.3 min for many fluctuating regions). In addition, we study the afterglow VLT/FORS2 spectrum, the optical-to-X-ray spectral energy distribution (SED) and the time decay. The SED is best fit with a broken power law with slopes {\\beta}opt = 0.71 \\pm 0.01 and {\\beta}X = 1.59 \\...

  17. Effect of GRB spectra on the empirical luminosity correlations and the GRB Hubble diagram

    CERN Document Server

    Lin, Hai-Nan; Chang, Zhe

    2016-01-01

    The spectra of gamma-ray bursts (GRBs) in a wide energy range can usually be well described by the Band function, which is a two smoothly jointed power laws cutting at a breaking energy. Below the breaking energy, the Band function reduces to a cut-off power law, while above the breaking energy it is a simple power law. However, for some detectors (such as the Swift-BAT) whose working energy is well below or just near the breaking energy, the observed spectra can be fitted to cut-off power law with enough precision. Besides, since the energy band of Swift-BAT is very narrow, the spectra of most GRBs can be fitted well even using a simple power law. In this paper, with the most up-to-date sample of Swift-BAT GRBs, we study the effect of different spectral models on the empirical luminosity correlations, and further investigate the effect on the reconstruction of GRB Hubble diagram. We mainly focus on two luminosity correlations, i.e., the Amati relation and Yonetoku relation. We calculate these two luminosity ...

  18. Deep Ly alpha imaging of two z=2.04 GRB host galaxy fields

    DEFF Research Database (Denmark)

    Fynbo, J.P.U.; Møller, Per; Thomsen, Bente

    2002-01-01

    We report on the results of deep narrow-band Lyalpha and broad-band U and I imaging of the fields of two Gamma-Ray bursts at redshift z = 2.04 (GRB 000301C and GRB 000926). We find that the host galaxy of GRB 000926 is an extended (more than 2 arcsec), strong Lyalpha emitter with a rest-frame equ......We report on the results of deep narrow-band Lyalpha and broad-band U and I imaging of the fields of two Gamma-Ray bursts at redshift z = 2.04 (GRB 000301C and GRB 000926). We find that the host galaxy of GRB 000926 is an extended (more than 2 arcsec), strong Lyalpha emitter with a rest...

  19. Deep Ly alpha imaging of two z=2.04 GRB host galaxy fields

    DEFF Research Database (Denmark)

    Fynbo, J.P.U.; Møller, Per; Thomsen, Bente

    2002-01-01

    We report on the results of deep narrow-band Lyalpha and broad-band U and I imaging of the fields of two Gamma-Ray bursts at redshift z = 2.04 (GRB 000301C and GRB 000926). We find that the host galaxy of GRB 000926 is an extended (more than 2 arcsec), strong Lyalpha emitter with a rest-frame equ......We report on the results of deep narrow-band Lyalpha and broad-band U and I imaging of the fields of two Gamma-Ray bursts at redshift z = 2.04 (GRB 000301C and GRB 000926). We find that the host galaxy of GRB 000926 is an extended (more than 2 arcsec), strong Lyalpha emitter with a rest...

  20. Individual Differences in Disgust Sensitivity Do Not Influence Moral Reasoning, but a Discipline-Specific Ethics Course Does

    Directory of Open Access Journals (Sweden)

    Lisa M. McCool

    2014-07-01

    Full Text Available The purpose of this research study was to determine undergraduate students’ perceptions of ethical dilemmas as a means of measuring general concern for leadership ethics within the marketplace. With the end goal of identifying best practices for ethics education in business and to further aid our understanding of how individual factors, such as disgust sensitivity, can alter students’ moral assessments, we measured the relationship between emotion and cognition in affecting ethical decision making. We found specific coursework in business ethics can produce a significant gain in moral reasoning. These results suggest that in the absence of strong moral intuitions, discipline-specific ethics coursework can lead to more postconventional moral decision making.

  1. Operating Water Cherenkov Detectors in high altitude sites for the Large Aperture GRB Observatory

    CERN Document Server

    Allard, D; Asorey, H; Barros, H; Bertou, X; Castillo, M; Chirinos, J M; De Castro, A; Flores, S; González, J; Berisso, M Gomez; Grajales, J; Guada, C; Day, W R Guevara; Ishitsuka, J; López, J A; Martínez, O; Melfo, A; Meza, E; Loza, P Miranda; Barbosa, E Moreno; Murrugarra, C; Núñez, L A; Ormachea, L J Otiniano; Pérez, G; Perez, Y; Ponce, E; Quispe, J; Quintero, C; Rivera, H; Rosales, M; Rovero, A C; Saavedra, O; Salazar, H; Tello, J C; Peralda, R Ticona; Varela, E; Velarde, A; Villaseñor, L; Wahl, D; Zamalloa, M A

    2009-01-01

    Water Cherenkov Detectors (WCD) are efficient detectors for detecting GRBs in the 10 GeV - 1 TeV energy range using the single particle technique, given their sensitivity to low energy secondary photons produced by high energy photons when cascading in the atmosphere. The Large Aperture GRB Observatory (LAGO) operates arrays of WCD in high altitude sites (above 4500 m a.s.l.) in Bolivia, Mexico and Venezuela, with planned extension to Peru. Details on the operation and stability of these WCD in remote sites with high background rates of particles will be detailed, and compared to simulations. Specific issues due to operation at high altitude, atmospheric effects and solar activity, as well as possible hardware enhancements will also be presented.

  2. Voltage-sensitive dye recording from axons, dendrites and dendritic spines of individual neurons in brain slices.

    Science.gov (United States)

    Popovic, Marko; Gao, Xin; Zecevic, Dejan

    2012-11-29

    phototoxic effects (4, 6, 12, 13). At present, we take advantage of the superb brightness and stability of a laser light source at near-optimal wavelength to maximize the sensitivity of the V(m)-imaging technique. The current sensitivity permits multiple site optical recordings of V(m) transients from all parts of a neuron, including axons and axon collaterals, terminal dendritic branches, and individual dendritic spines. The acquired information on signal interactions can be analyzed quantitatively as well as directly visualized in the form of a movie.

  3. GRB 090510: A Genuine Short GRB from a Binary Neutron Star Coalescing into a Kerr-Newman Black Hole

    Science.gov (United States)

    Ruffini, R.; Muccino, M.; Aimuratov, Y.; Bianco, C. L.; Cherubini, C.; Enderli, M.; Kovacevic, M.; Moradi, R.; Penacchioni, A. V.; Pisani, G. B.; Rueda, J. A.; Wang, Y.

    2016-11-01

    In a new classification of merging binary neutron stars (NSs) we separate short gamma-ray bursts (GRBs) into two subclasses. The ones with {E}{iso}≲ {10}52 erg coalesce to form a massive NS and are indicated as short gamma-ray flashes (S-GRFs). The hardest, with {E}{iso}≳ {10}52 erg, coalesce to form a black hole (BH) and are indicated as genuine short GRBs (S-GRBs). Within the fireshell model, S-GRBs exhibit three different components: the proper GRB (P-GRB) emission, observed at the transparency of a self-accelerating baryon-{e}+{e}- plasma; the prompt emission, originating from the interaction of the accelerated baryons with the circumburst medium; and the high-energy (GeV) emission, observed after the P-GRB and indicating the formation of a BH. GRB 090510 gives the first evidence for the formation of a Kerr BH or, possibly, a Kerr-Newman BH. Its P-GRB spectrum can be fitted by a convolution of thermal spectra whose origin can be traced back to an axially symmetric dyadotorus. A large value of the angular momentum of the newborn BH is consistent with the large energetics of this S-GRB, which reach in the 1-10,000 keV range {E}{iso}=(3.95+/- 0.21)× {10}52 erg and in the 0.1-100 GeV range {E}{LAT}=(5.78+/- 0.60)× {10}52 erg, the most energetic GeV emission ever observed in S-GRBs. The theoretical redshift {z}{th}=0.75+/- 0.17 that we derive from the fireshell theory is consistent with the spectroscopic measurement z=0.903+/- 0.003, showing the self-consistency of the theoretical approach. All S-GRBs exhibit GeV emission, when inside the Fermi-LAT field of view, unlike S-GRFs, which never evidence it. The GeV emission appears to be the discriminant for the formation of a BH in GRBs, confirmed by their observed overall energetics.

  4. Correlated optical and gamma emissions from GRB 081126

    CERN Document Server

    Klotz, Alain; Atteia, J L; Boër, Michel; Coward, David M; Imerito, Alan C

    2009-01-01

    We present an analysis of time-resolved optical emissions observed from the gamma-ray burst GRB 081126 during the prompt phase. The analysis employed time-resolved photometry using optical data obtained by the TAROT telescope, using BAT data from the Swift spacecraft, and time-resolved spectroscopy at high energies from the GBM instrument onboard the Fermi spacecraft. The optical emission of GRB 081126 is found to be compatible with the second gamma emission pulse shifted by a positive time lag of 8.4 $\\pm$ 3.9 s. This is the first well-resolved observation of a time lag between optical and gamma emissions during a gamma-ray burst. Our observations could potentially provide new constraints on the fireball model for gamma-ray burst early emissions. Furthermore, observations of time lags between optical and gamma ray photons provides an exciting opportunity to constrain quantum gravity theories.

  5. On GRB Physics Revealed by FERMI/LAT

    CERN Document Server

    Li, Zhuo

    2012-01-01

    We discuss the implications of Fermi/LAT observations on several aspects of gamma-ray burst (GRB) physics, including the radiation process, the emission sites, the bulk Lorentz factor, and the pre-shock magnetic field: (1) MeV-range emission favors synchrotron process but the highest energy (>10GeV) emission may not be synchrotron origin, more likely inverse Compton origin; (2) GRB should have multi-zone emission region, with MeV emission produced at smaller radii while optical and >100MeV emission at larger radii; (3) the bulk Lorentz factor can be a few 100's, much lower than 10^3, in multi-zone model; (4) the upstream magnetic field of afterglow shock is strongly amplified to be at least in mG scale.

  6. Time resolved spectroscopy of GRB 030501 using INTEGRAL

    DEFF Research Database (Denmark)

    Beckmann, V.; Borkowski, J.; Courvoisier, T.J.L.;

    2003-01-01

    The gamma-ray instruments on-board INTEGRAL offer an unique opportunity to perform time resolved analysis on GRBs. The imager IBIS allows accurate positioning of GRBs and broad band spectral analysis, while SPI provides high resolution spectroscopy. GRB 030501 was discovered by the INTEGRAL Burst...... Alert System in the ISGRI field of view. Although the burst was fairly weak (fluence F20-200 keV similar or equal to 3.5x10(-6) erg cm(-2)) it was possible to perform time resolved spectroscopy with a resolution of a few seconds. The GRB shows a spectrum in the 20-400 keV range which is consistent...

  7. IceCube and GRB neutrinos propagating in quantum spacetime

    Science.gov (United States)

    Amelino-Camelia, Giovanni; Barcaroli, Leonardo; D'Amico, Giacomo; Loret, Niccoló; Rosati, Giacomo

    2016-10-01

    Two recent publications have reported intriguing analyses, tentatively suggesting that some aspects of IceCube data might be manifestations of quantum-gravity-modified laws of propagation for neutrinos. We here propose a strategy of data analysis which has the advantage of being applicable to several alternative possibilities for the laws of propagation of neutrinos in a quantum spacetime. In all scenarios here of interest one should find a correlation between the energy of an observed neutrino and the difference between the time of observation of that neutrino and the trigger time of a GRB. We select accordingly some GRB-neutrino candidates among IceCube events, and our data analysis finds a rather strong such correlation. This sort of study naturally lends itself to the introduction of a "false alarm probability", which for our analysis we estimate conservatively to be of 1%. We therefore argue that our findings should motivate a vigorous program of investigation following the strategy here advocated.

  8. IceCube and GRB neutrinos propagating in quantum spacetime

    CERN Document Server

    Amelino-Camelia, Giovanni; D'Amico, Giacomo; Loret, Niccoló; Rosati, Giacomo

    2016-01-01

    Two recent publications have reported intriguing analyses, tentatively suggesting that some aspects of IceCube data might be manifestations of quantum-gravity-modified laws of propagation for neutrinos. We here propose a strategy of data analysis which has the advantage of being applicable to several alternative possibilities for the laws of propagation of neutrinos in a quantum spacetime. In all scenarios here of interest one should find a correlation between the energy of an observed neutrino and the difference between the time of observation of that neutrino and the trigger time of a GRB. We select accordingly some GRB-neutrino candidates among IceCube events, and our data analysis finds a rather strong such correlation. This sort of studies naturally lends itself to the introduction of a "false alarm probability", which for our analysis we estimate conservatively to be of 1%. We therefore argue that our findings should motivate a vigorous program of investigation following the strategy here advocated.

  9. Individually addressable microelectrode arrays fabricated with gold-coated pencil graphite particles for multiplexed and high sensitive impedance immunoassays.

    Science.gov (United States)

    Zhang, Yun; Wang, Hua; Nie, Jinfang; Zhang, Yuwei; Shen, Guoli; Yu, Ruqin

    2009-09-15

    A renewable, site-selective immobilization platform of microelectrode array (MEA) for multiplexed immunoassays has been initially developed using pencil graphite particles coated with gold layers as microelectrodes. The graphite particles available on the common pencil were utilized for directing the electro-deposition of gold layers with uniform microstructures which displayed a well-defined sigmoidal voltammetric response. In the concept-of-proof experiments, the resulting MEA platform was modified with functionalized monolayer, on which anti-human IgG antibodies could be stably immobilized in a site-selective way through binding chemistry to selectively capture human IgG antigens from the sample media. The subsequent introduction of anti-human IgG antibodies conjugated with 15 nm electro-active gold nanoparticles to recognize the captured IgG proteins resulted in a significant decrease in the interfacial electron-transfer resistance. High sensitive electrochemical quantification by gold nanoparticle-amplified impedance responses could thus be achieved. Experimental results show that the developed MEA sensor can allow for the detection of human IgG with wide linear range (0.05-100 ng ml(-1)) and sensitivity over 10(3) larger than that of the conventional, bulk gold electrode. The rapid regeneration of the used MEA platform can additionally be realized by a simple electrochemical treatment. The high selectivity of four individually addressable MEA platforms for multiple antigens in a single sample has been further demonstrated in the multiplexed immunoassay experiments. Such a site-selective immobilization strategy of MEA platform may open a new door towards the development of various simple, sensitive, cost-effective, and reusable biological sensors and biochips.

  10. Early re-brightening of the afterglow of GRB 050525a

    CERN Document Server

    Klotz, A; Atteia, J L; Stratta, G; Behrend, R; Malacrino, F; Damerdji, Y

    2005-01-01

    We present time resolved optical data acquired by the TAROT automated observatory on the afterglow of GRB 050525a from 6 to 136 minutes after the GRB. We evidence a rapid re-brightening of 0.65 magnitude of the afterglow at $\\sim$ 33 min after the GRB. The decay slope $\\alpha$ is $1.14\\pm 0.07$ in the first part and is $1.23\\pm 0.27$ after the re-brightening event. The afterglow of GRB 050525a is the third known afterglow that exhibits a re-brightening event begining at 0.01--0.02 day in the rest time frame.

  11. Time-resolved GRB spectra in the complex radiation of synchrotron and Compton processes

    Science.gov (United States)

    Jiang, Y. G.; Hu, S. M.; Chen, X.; Li, K.; Guo, D. F.; Li, Y. T.; Li, H. Z.; Zhao, Y. Y.; Lin, H. N.; Chang, Z.

    2016-03-01

    Under the steady-state condition, the spectrum of electrons is investigated by solving the continuity equation under the complex radiation of both the synchrotron and Compton processes. The resulted gamma-ray burst (GRB) spectrum is a broken power law in both the fast and slow cooling phases. On the basis of this electron spectrum, the spectral indices of the Band function in four different phases are presented. In the complex radiation frame, the detail investigation on physical parameters reveals that three models can answer the α ˜ -1 problem, which are the synchrotron plus synchrotron self-Compton in the internal and the external shock models, and the synchrotron plus the external Compton processes in the external shock model. A possible marginal to fast cooling phase transition in GRB 080916C is discussed. The time-resolved spectra in different main pulses of GRB 100724B, GRB 100826A and GRB 130606B are investigated. We found that the flux is proportional to the peak energy in almost all main pulses. A significant (5σ) correlation for Fp ˜ Ep is evident the first main pulse of GRB 100826A, and three marginally significant (3σ) correlations Fp ˜ Ep are found in main pulses of GRB 100826A and GRB 130606B. The correlation between spectral index and Ep at 3 ˜ 4σ level are observed in the first main pulse of GRB 100826A. Such correlations are possible explained in the complex radiation scenario.

  12. Fermi-LAT Observations of the Gamma-Ray Burst GRB 130427A

    Science.gov (United States)

    Ackermann, M.; Ajello, M.; Asano, K.; Atwood, W. B.; Axelsson, M.; Baldini, L.; Ballet, J.; Barbiellini, G.; Baring, M. G.; Bastieri, D.; Gehrels, Cornelis

    2013-01-01

    The observations of the exceptionally bright gamma-ray burst (GRB) 130427A by the Large Area Telescope aboard the Fermi Gamma-ray Space Telescope provide constraints on the nature of these unique astrophysical sources. GRB 130427A had the largest fluence, highest-energy photon (95 GeV), longest gamma-ray duration (20 hours), and one of the largest isotropic energy releases ever observed from a GRB. Temporal and spectral analyses of GRB 130427A challenge the widely accepted model that the nonthermal high-energy emission in the afterglow phase of GRBs is synchrotron emission radiated by electrons accelerated at an external shock.

  13. Modeling the Radio and Optical/NIR Afterglows of GRB 980703: a Numerical Study

    Science.gov (United States)

    Kong, S. W.; Huang, Y. F.

    2008-10-01

    GRB 980703 has extensive available multiband afterglow data. Especially, its radio afterglows were very bright and monitored until more than 1000 days after the trigger time. This makes GRB 980703 a precious sample in GRB research. We calculate the radio and optical/NIR afterglows of GRB 980703 numerically, by using a set of generic dynamical equations. It is found that the observations consist with the theoretical expectation of the standard fireball model well. Our result suggests that the jet opening angle is ~13°, the number density of the surrounding medium is ~30 cm-3, and the isotropic equivalent kinetic energy of the explosion is ~3.8×1052 ergs.

  14. A SUPRAMASSIVE MAGNETAR CENTRAL ENGINE FOR GRB 130603B

    Energy Technology Data Exchange (ETDEWEB)

    Fan, Yi-Zhong; Jin, Zhi-Ping; Wei, Da-Ming [Key Laboratory of dark Matter and Space Astronomy, Purple Mountain Observatory, Chinese Academy of Science, Nanjing 210008 (China); Yu, Yun-Wei [Institute of Astrophysics, Central China Normal University, Wuhan 430079 (China); Xu, Dong [Dark Cosmology Centre, Niels Bohr Institute, University of Copenhagen, Juliane Maries Vej 30, DK-2100 Copenhagen (Denmark); Wu, Xue-Feng [Chinese Center for Antarctic Astronomy, Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008 (China); Zhang, Bing, E-mail: yzfan@pmo.ac.cn, E-mail: zhang@physics.unlv.edu [Department of Physics and Astronomy, University of Nevada, Las Vegas, NV 89154 (United States)

    2013-12-20

    We show that the peculiar early optical emission and, in particular, the X-ray afterglow emission of the short-duration burst GRB 130603B can be explained by continuous energy injection into the blastwave from a supramassive magnetar central engine. The observed energetics and temporal/spectral properties of the late infrared bump (i.e., the {sup k}ilonova{sup )} are also found to be consistent with emission from the ejecta launched during a neutron star (NS)-NS merger and powered by a magnetar central engine. The isotropic-equivalent kinetic energies of both the gamma-ray burst (GRB) blastwave and the kilonova are approximately E{sub k} ∼ 10{sup 51} erg, consistent with being powered by a near-isotropic magnetar wind. However, this relatively small value requires that most of the initial rotational energy of the magnetar (∼a few × 10{sup 52} erg) is carried away by gravitational wave radiation. Our results suggest that (1) the progenitor of GRB 130603B was a NS-NS binary system, the merger product of which would have been a supramassive NS that lasted for about ∼1000 s; (2) the equation of state of the nuclear matter should be stiff enough to allow the survival of a long-lived supramassive NS; thus this suggested that the detection of the bright electromagnetic counterparts of gravitational wave triggers without short GRB associations is promising in the upcoming Advanced LIGO/VIRGO era.

  15. Spectroscopic Observations of the Bright Afterglow of GRB021004

    Science.gov (United States)

    Harrison, Fiona

    2001-09-01

    One of the holy grails of gamma-ray burst research is to detect X-ray line signatures from an afterglow with high statistical significance. Of all possible observations, this perhaps offers the best chance of constraining the GRB mechanism and environment, and could provide the "smoking gun" signature connecting GRBs to massive stellar deaths. In order to accomplish this, we know long observations within one day of the event are necessary.

  16. The H.E.S.S. II GRB Program

    CERN Document Server

    Parsons, R D; Füssling, M; Hoischen, C; Holler, M; Mitchell, A M W; Pühlhofer, G; Rowell, G; Wagner, S; Bissaldi, E; O'Brien, P; Tam, P H T

    2015-01-01

    Gamma-ray bursts (GRBs) are some of the most energetic and exotic events in the Universe, however their behaviour at the highest energies (>10 GeV) is largely unknown. Although the Fermi-LAT space telescope has detected several GRBs in this energy range, it is limited by the relatively small collection area of the instrument. The H.E.S.S. experiment has now entered its second phase by adding a fifth telescope of 600 m$^{2}$ mirror area to the centre of the array. This new telescope increases the energy range of the array, allowing it to probe the sub-100 GeV range while maintaining the large collection area of ground based gamma-ray observatories, essential to probing short-term variability at these energies. We will present a description of the GRB observation scheme used by the H.E.S.S. experiment, summarising the behaviour and performance of the rapid GRB repointing system, the conditions under which potential GRB repointings are made and the data analysis scheme used for these observations.

  17. The 050709 macronova and the GRB/macronova connection

    CERN Document Server

    Jin, Zhi-Ping; Li, Xiang; Tanaka, Masaomi; D'Avanzo, Paolo; Fan, Yi-Zhong; Covino, Stefano; Wei, Da-Ming; Piran, Tsvi

    2016-01-01

    We reanalyzed the publicly-available optical/near-infrared afterglow observations of GRB 050709, the first short GRB from which an optical afterglow was detected. The $I$-band/F814W-band light curve is significantly shallower than the $R$-band light curve. This additional low-luminosity soft component can be a signature of a Li-Paczy\\'{n}ski macronova (also known as kilonova) arising from $\\sim 0.05~M_\\odot$ r-process material launched by a compact binary merger. As macronovae are relatively weak and soft they can be identified only within the afterglows of relatively nearby ($z<0.4$) bursts that have sufficient near-infrared/optical data. There are five such events: GRBs 050709, 060505, 060614, 061201 and 130603B. However, the redshift of 061201 is unclear and there is doubt concerning the origin of GRB 060505. Remarkably, evidence for a macronova signature is found in the afterglow of each one of the remaining three events. This demonstrates that macronovae are ubiquitous. The significant mass ejection s...

  18. Implications for the Origin of GRB 051103 from LIGO Observations

    Science.gov (United States)

    Bizouard, M. A.; Dietz, A.; Guidi, G. M.; Was, M.; Camp, J. B.; Cannizzo, J.; Stroeer, A. S.; Blackburn, L.

    2012-01-01

    We present the results of a LIGO search for gravitational waves (GWs) associated with GRB 051103, a short-duration hard-spectrum gamma-ray burst whose electromagnetically determined sky position is coincident with the spiral galaxy M81, which is 3.6Mpc from Earth. Possible progenitors for short-hard GRBs include compact object mergers and soft gamma repeater (SGR) giant flares. A merger progenitor would produce a characteristic GW signal that should be detectable at the distance of M81, while GW emission from an SGR is not expected to be detectable at that distance. We found no evidence of a GW signal associated with GRB 051103. Assuming weakly beamed gamma-ray emission with a jet semi-angle of 30. we exclude a binary neutron star merger in M81 as the progenitor with a confidence of 98%. Neutron star-black hole mergers are excluded with > 99% confidence. If the event occurred in M81 our findings support the hypothesis that GRB 051103 was due to an SGR giant flare, making it the most distant extragalactic magnetar observed to date.

  19. Time resolved spectroscopy of GRB030501 using INTEGRAL

    CERN Document Server

    Beckmann, V; Courvoisier, Thierry J L; Goetz, D; Hudec, R; Hroch, F; Lund, N; Mereghetti, S; Shaw, S E; Wigger, C

    2003-01-01

    The Gamma-ray instruments on-board INTEGRAL offer an unique opportunity to perform time resolved analysis on GRBs. The imager IBIS allows accurate positiioning of GRBs and broad band spectral analysis, while SPI provides high resolution spectroscopy. GRB 030501 was discovered by the INTEGRAL Burst Alert System in the ISGRI field of view. Although the burst was fairly weak (fluence F = 3.5 * 10^-6 erg cm^-2 in the 20-200 keV energy band) it was possible to perform time resolved spectroscopy with a resolution of a few seconds. The GRB shows a spectrum in the 20 - 400 keV range which is consistent with a spectral photon index of -1.7. No emission line or spectral break was detectable in the spectrum. Although the flux seems to be correlated with the hardness of the GRB spectrum, there is no clear soft to hard evolution seen over the duration of the burst. The INTEGRAL data have been compared with results from the Ulysses and RHESSI experiments.

  20. A compact binary merger model for GRB 050509b

    CERN Document Server

    Lee, W H; Granot, J; Lee, William H.; Ramirez-Ruiz, Enrico; Granot, Jonathan

    2005-01-01

    The first X-ray afterglow for a short (30 ms), hard gamma-ray burst was detected by Swift on 9 May 2005 (GRB 050509b). No optical or radio counterpart was identified in follow--up observations. The tentative association of the GRB with a nearby giant elliptical galaxy at redshift z=0.2248 would imply the progenitor had traveled several tens of kpc from its point of origin, in agreement with expectations linking these events to the final merger of compact binaries driven by gravitational wave emission. We model the dynamical merger of such a system and the time--dependent evolution of the accretion tori thus created. The resulting energetics, variability, and expected durations are consistent with GRB 050509b originating from the tidal disruption of a neutron star by a stellar mass black hole, or of the merger of two neutron stars followed by prompt gravitational collapse of the massive remnant. We discuss how the available gamma-ray and X-ray data provides a probe for the nature of the relativistic ejecta and...

  1. Testing the Predictions of the Universal Structured GRB Jet Model

    CERN Document Server

    Nakar, E; Guetta, D; Nakar, Ehud; Granot, Jonathan; Guetta, Dafne

    2004-01-01

    The two leading models for the structure of GRB jets are (1) the uniform jet model, where the energy per solid angle, $\\epsilon$, is roughly constant within some finite half-opening angle, $\\theta_j$, and sharply drops outside of $\\theta_j$, and (2) the universal structured jet (USJ) model, where all GRB jets are intrinsically identical, and $\\epsilon$ drops as the inverse square of the angle from the jet axis. The simplicity of the USJ model gives it a strong predictive power, including a specific prediction for the observed GRB distribution as a function of both the redshift $z$ and the viewing angle $\\theta$ from the jet axis. We show that the current sample of GRBs with known $z$ and estimated $\\theta$ does not agree with the predictions of the USJ model. This can be best seen for a relatively narrow range in $z$, in which the USJ model predicts that most GRBs should be near the upper end of the observed range in $\\theta$, while in the observed sample most GRBs are near the lower end of that range. Since ...

  2. Discovery of Early Optical Emission from GRB 021211

    CERN Document Server

    Fox, D W; Soderberg, A M; Berger, E; Kulkarni, S R; Sari, R; Frail, D A; Harrison, F A; Yost, S A; Matthews, K; Peterson, B A; Tanaka, I; Christiansen, J; Moriarty-Schieven, G H

    2003-01-01

    We report our discovery and early time optical, near-infrared, and radio wavelength follow-up observations of the afterglow of the gamma-ray burst GRB 021211. Our optical observations, beginning 21 min after the burst trigger, demonstrate that the early afterglow of this burst is roughly three magnitudes fainter than the afterglow of GRB 990123 at similar epochs, and fainter than almost all known afterglows at an epoch of 1d after the GRB. Our near-infrared and optical observations indicate that this is not due to extinction. Combining our observations with data reported by other groups, we identify the signature of a reverse shock. This reverse shock is not detected to a 3-sigma limit of 110 uJy in an 8.46-GHz VLA observation at t=0.10d, implying either that the Lorentz factor of the burst gamma ~ 1 week, we find that the late-time radio flux is suppressed by a factor of two relative to the >~ 80 uJy peak flux at optical wavelengths. This suppression is not likely to be due to synchrotron self-absorption or ...

  3. The Interpretation and Implication of the Afterglow of GRB 060218

    CERN Document Server

    Fan, Y; Xu, D; Fan, Yizhong; Piran, Tsvi; Xu, Dong

    2006-01-01

    The nearby GRB 060216/SN 2006aj was an extremely long, weak and very soft GRB. While it was peculiar in many aspects its late ($>10^4$ sec) X-ray afterglow showed a canonical power law decay. Assuming that this component arises due to a relativistic blast wave decelerated by a circumburst matter we infer that the blast wave's kinetic energy was rather high, $5 \\times 10^{50}$ erg, close to what is seen in other GRBs. The lack of a "jet break" implies that the outflow was wide $\\theta_j \\sim 1$. The rather weak early optical emission rules out a dense circumburst wind profile. It also constrains the initial Lorentz factor to be significantly lower than usual, $\\Gamma_{\\rm ini}\\sim 15$. The observed afterglow suggests that the medium surrounding a massive star progenitor (up to distances of $\\sim 10^{17}-10^{18}$ cm) is not the expected dense stellar wind (a similar result was seen in many other bursts and in particular in GRB 030329). This implies that the progenitor's wind was weak during the last 100-1000 ye...

  4. The rise of the afterglow in GRB 050820a

    CERN Document Server

    Genet, F; Mochkovitch, R

    2007-01-01

    The early optical afterglow of GRB 050820a recorded by the RAPTOR telescope shows both a contribution from the prompt emission and the initial rise of the afterglow. It is therefore well-suited for the study of the dynamical evolution of the GRB ejecta when it first undergoes the decelerating effect of the environment. This is a complex phase where the internal, reverse, and forward shocks can all be present simultaneously. We have developed a simplified model that can follow these different shocks in an approximate, but self-consistent way. It is applied to the case of GRB 050820a to obtain the prompt and afterglow light curves. We show that the rise of the afterglow during the course of the prompt emission has some important consequences. The reverse shock propagates back into the ejecta before internal shocks are completed, which affects the shape of the gamma-ray profile. We get the best results when the external medium has a uniform density, but obtaining a simultaneous fit of the prompt and afterglow em...

  5. Spectroscopic Discovery of the Supernova Associated with GRB 030329

    CERN Document Server

    Stanek, K Z; Garnavich, P M; Martini, P; Caldwell, P B N; Challis, P M; Brown, W; Schild, R; Krisciunas, K; Calkins, M L; Lee, J C; Hathi, N; Jansen, R; Windhorst, R A; Echevarria, L; Eisenstein, D J; Pindor, B; Olszewski, E W; Harding, P; Bersier, D F

    2003-01-01

    We present early observations of the afterglow of the Gamma-Ray Burst (GRB) 030329 and the spectroscopic discovery of its associated supernova. We obtained spectra of the afterglow of GRB 030329 each night from March 30.12 (0.6 days after the burst) to April 8.13 (UT) (9.6 days after the burst). The spectra cover a wavelength range of 350 nm to 850 nm. The early spectra consist of a power-law continuum (F_{nu} ~ nu^{-0.9}) with narrow emission lines originating from HII regions in the host galaxy, indicating a low redshift of z=0.1687. However, our spectra taken after 2003 Apr. 5 show broad peaks in flux characteristic of a supernova. Correcting for the afterglow emission, we find the spectrum of the supernova is remarkably similar to the type Ic `hypernova' SN 1998bw. While the presence of supernovae have been inferred from the light curves and colors of GRB afterglows in the past, this is the first direct, spectral confirmation that a subset of classical gamma-ray bursts originate from supernovae.

  6. Extinction and Absorption of the Afterglow of GRB980329

    CERN Document Server

    Reichart, D E; Metzger, M R; Quashnock, J M; Cole, D M; Castander, F J; Cooray, A R; Vanden Berk, Daniel E; Reichart, Daniel E.; Lamb, Donald Q.; Metzger, Mark R.; Quashnock, Jean M.; Cole, David M.; Castander, Francisco J.; Cooray, Asantha R.; Berk, Daniel E. Vanden

    1998-01-01

    We report R-, J- and K-band observations of the GRB980329 field made on April 1 with the APO 3.5-m telescope, and J- and K-band observations made between April 6 - 8 with the Keck-I 10-m telescope. We show that these data and other reported measurements are consistent with a power-law fading of the optical/NIR source that is coincident with the variable radio source VLA J0702+3850. This establishes this source as the afterglow of GRB980329. We construct a model of the observed optical/NIR and X-ray spectrum of burst afterglows that takes into account the extinction of optical/NIR light and the absorption of soft X rays by dust and gas along the line-of-sight to the burst and in any host galaxy. For GRB980329, we find a rest-frame V-band absorption magnitude of A_V(1+z) = 3.00 +/- 0.25 mag, assuming a power law for the intrinsic spectrum, and that the observed spectrum of the burst afterglow is fully consistent with extinction of the intrinsic spectrum in the optical/NIR. This value of A_V is too large to be c...

  7. The extremely red host galaxy of GRB 080207

    CERN Document Server

    Hunt, Leslie; Rossi, Andrea; Savaglio, Sandra; Cresci, Giovanni; Klose, Sylvio; Michalowski, Michal; Pian, Elena

    2011-01-01

    We present optical, near-infrared, and Spitzer IRAC and MIPS observations of the host galaxy of the dark gamma-ray burst GRB 080207. The host is faint, with extremely red optical-infrared colors ($R-K\\,=\\,6.3$, 24\\micron/$R-$band flux $\\sim1000$) making it an extremely red object (ERO) and a dust-obscured galaxy (DOG). The spectral energy distribution (SED) shows the clear signature of the 1.6 micron photometric "bump", typical of evolved stellar populations. We use this bump to establish the photometric redshift $z_{\\rm phot}$ as 2.2$^{+0.2}_{-0.3}$, using a vast library of SED templates, including M 82. The star-formation rate (SFR) inferred from the SED fitting is $\\sim$119\\msun\\,yr$^{-1}$, the stellar mass $3\\times10^{11}$\\,\\msun, and \\av\\ extinction from 1-2\\,mag. The ERO and DOG nature of the host galaxy of the dark GRB 080207 may be emblematic of a distinct class of dark GRB hosts, with high SFRs, evolved and metal-rich stellar populations, and significant dust extinction within the host galaxy.

  8. Cooling via one hand improves physical performance in heat-sensitive individuals with Multiple Sclerosis: A preliminary study

    Directory of Open Access Journals (Sweden)

    Murray Julie

    2008-05-01

    Full Text Available Abstract Background Many individuals afflicted with multiple sclerosis (MS experience a transient worsening of symptoms when body temperature increases due to ambient conditions or physical activity. Resulting symptom exacerbations can limit performance. We hypothesized that extraction of heat from the body through the subcutaneous retia venosa that underlie the palmar surfaces of the hands would reduce exercise-related heat stress and thereby increase the physical performance capacity of heat-sensitive individuals with MS. Methods Ten ambulatory MS patients completed one or more randomized paired trials of walking on a treadmill in a temperate environment with and without cooling. Stop criteria were symptom exacerbation and subjective fatigue. The cooling treatment entailed inserting one hand into a rigid chamber through an elastic sleeve that formed an airtight seal around the wrist. A small vacuum pump created a -40 mm Hg subatmospheric pressure enviinside the chamber where the palmar surface of the hand rested on a metal surface maintained at 18–22°C. During the treatment trials, the device was suspended from above the treadmill on a bungee cord so the subjects could comfortably keep a hand in the device without having to bear its weight while walking on the treadmill. Results When the trials were grouped by treatment only, cooling treatment increased exercise durations by 33% (43.6 ± 17.1 min with treatment vs. 32.8 ± 10.9 min. without treatment, mean ± SD, p -6, paired t-test, n = 26. When the average values were calculated for the subjects who performed multiple trials before the treatment group results were compared, cooling treatment increased exercise duration by 35% (42.8 ± 16.4 min with treatment vs. 31.7 ± 9.8 min. without treatment, mean ± SD, p Conclusion These preliminary results suggest that utilization of the heat transfer capacity of the non-hairy skin surfaces can enable temperature-sensitive individuals with MS to

  9. A Search for gravitational waves associated with the gamma ray burst GRB030329 using the LIGO detectors

    Energy Technology Data Exchange (ETDEWEB)

    Abbott, B.; Abbott, R.; Adhikari, R.; Ageev, A.; Allen, B.; Amin, R.; Anderson, S.B.; Anderson, W.G.; Araya, M.; Armandula, H.; Ashley, M.; Asiri, F.; Aufmuth, P.; Aulbert, C.; Babak, S.; Balasubramanian, R.; Ballmer, S.; Barish, B.C.; Barker, C.; Barker, D.; Barnes, M.; /Potsdam, Max Planck Inst. /Hannover, Max Planck Inst. Grav. /Australian

    2005-01-01

    We have performed a search for bursts of gravitational waves associated with the very bright Gamma Ray Burst GRB030329, using the two detectors at the LIGO Hanford Observatory. Our search covered the most sensitive frequency range of the LIGO detectors (approximately 80-2048 Hz), and we specifically targeted signals shorter than {approx_equal}150 ms. Our search algorithm looks for excess correlated power between the two interferometers and thus makes minimal assumptions about the gravitational waveform. We observed no candidates with gravitational wave signal strength larger than a pre-determined threshold. We report frequency dependent upper limits on the strength of the gravitational waves associated with GRB030329. Near the most sensitive frequency region, around {approx_equal}250 Hz, our root-sum-square (RSS) gravitational wave strain sensitivity for optimally polarized bursts was better than h{sub RSS} {approx_equal} 6 x 10{sup -21} Hz{sup -1/2}. Our result is comparable to the best published results searching for association between gravitational waves and GRBs.

  10. GRB 110721A: PHOTOSPHERE 'DEATH LINE' AND THE PHYSICAL ORIGIN OF THE GRB BAND FUNCTION

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Bing; Lu Ruijing; Liang Enwei [Department of Physics and GXU-NAOC Center for Astrophysics and Space Sciences, Guangxi University, Nanning 530004 (China); Wu Xuefeng [Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008 (China)

    2012-10-20

    The prompt emission spectra of gamma-ray bursts (GRBs) usually have a dominant component that is well described by a phenomenological Band function. The physical origin of this spectral component is debated. Although the traditional interpretation is synchrotron radiation of non-thermal electrons accelerated in internal shocks or magnetic dissipation regions, the growing trend within the community is to interpret this component as modified thermal emission from a dissipative photosphere of a GRB fireball. We analyze the time-dependent spectrum of GRB 110721A detected by the Fermi Gamma-Ray Burst Monitor and Large Area Telescope, and pay special attention to the rapid evolution of the peak energy E{sub p} . We define a 'death line' of thermally dominated dissipative photospheric emission in the E{sub p} -L plane, and show that E{sub p} of GRB 110721A at the earliest epoch has a very high E{sub p} {approx} 15 MeV that is beyond the 'death line'. Together with the finding that an additional 'shoulder' component exists in this burst that is consistent with a photospheric origin, we suggest that at least for some bursts, the Band component is not from a dissipative photosphere, but must invoke a non-thermal origin (e.g., synchrotron or inverse Compton) in the optically thin region of a GRB outflow. We also suggest that the rapid hard-to-soft spectral evolution is consistent with the quick discharge of magnetic energy in a magnetically dominated outflow in the optically thin region.

  11. GRB 140619B: a short GRB from a binary neutron stars merger leading to the black hole formation

    CERN Document Server

    Muccino, M; Kovacevic, M; Izzo, L; Oliveira, F G; Rueda, J A; Bianco, C L; Enderli, M; Penacchioni, A V; Pisani, G B; Wang, Y; Zaninoni, E

    2014-01-01

    Following the recent identification of the prototypical short GRB 090227B originating from a binary neutron star (NS) merger and forming a black hole (BH), we present here a new example of such sources, GRB 140619B. The time-resolved spectral analysis of the early ~0.2s of the Fermi-GBM data, allows for the identification of the characteristic features of the e^+e^- plasma at transparency (P-GRB): i.e., a thermal spectrum with an observed temperature kT=(324+/-33)keV which represents ~40% of the total source fluence. The subsequent emission, with no thermal spectrum, is identified with the prompt emission. We consequently deduce a theoretical redshift of z=2.67+/-0.37, a total burst energy E+/-=(6.03+/-0.79)x10^{52}erg, a baryon load B=(5.52+/-0.73)x10^{-5}, and a Lorentz factor at transparency Gamma=(1.08+/-0.08)x10^4. From the simulation of the prompt emission we determine the average density of the circumburst medium (CBM), n_CBM=(4.7+/-1.2)x10^{-5}cm^{-3}, typical of the galactic halo environment. These l...

  12. Individual differences in the sensitivity to serotonergic drugs: a pharmacobehavioural approach using rats selected on the basis of their response to novelty

    OpenAIRE

    Verheij, Michel M. M.; Veenvliet, Jesse V.; Groot Kormelink, Tom; Steenhof, Maaike; Cools, Alexander R.

    2009-01-01

    Rationale The mechanisms underlying individual differences in the response to serotonergic drugs are poorly understood. Rat studies may contribute to our knowledge of the neuronal substrates that underlie these individual differences. Objectives A pharmacobehavioural study was performed to assess individual differences in the sensitivity to serotonergic drugs in rats that were selected based on their response to a novel environment. Methods Low responders (LR) and high responders (HR) to nove...

  13. The Katzman Automatic Imaging Telescope Gamma-Ray Burst Alert System, and Observations of GRB 020813

    CERN Document Server

    Li, W; Chornock, R; Jha, S; Li, Weidong; Filippenko, Alexei V.; Chornock, Ryan; Jha, Saurabh

    2003-01-01

    We present the technical details of the gamma-ray burst (GRB) alert system of the Katzman Automatic Imaging Telescope (KAIT) at Lick Observatory, and the successful observations of the GRB 020813 optical afterglow with this system. KAIT responds to GRB alerts robotically, interrupts its pre-arranged program, and takes a sequence of images for each GRB alert. A grid-imaging procedure is used to increase the efficiency of the early-time observations. Different sequences of images have been developed for different types of GRB alerts. With relatively fast telescope slew and CCD readout speed, KAIT can typically complete the first observation within 60 s after receiving a GRB alert, reaching a limiting magnitude of $\\sim 19$. Our reduction of the GRB 020813 data taken with KAIT shows that unfiltered magnitudes can be reliably transformed to a standard passband with a precision of $\\sim$5%, given that the color of the object is known. The GRB 020813 optical afterglow has an exceptionally slow early-time power-law ...

  14. Spatially-resolved dust properties of the GRB 980425 host galaxy

    DEFF Research Database (Denmark)

    Michałowski, Michał J.; Hunt, L. K.; Palazzi, E.

    2014-01-01

    ), located 800 pc away from the GRB position. The host is characterised by low dust content and high fraction of UV-visible star-formation, similar to other dwarf galaxies. Such galaxies are abundant in the local universe, so it is not surprising to find a GRB in one of them, assuming the correspondence...

  15. Discovery of the optical counterpart and early optical observations of GRB 990712

    DEFF Research Database (Denmark)

    Sahu, K.C.; Vreesvijk, P.; Bakos, G.

    2000-01-01

    of the decay is similar, but the goodness of fit is worse, which would imply that either this GRB is not associated with an underlying supernova or the underlying supernova is much fainter than the supernova associated with GRB 980425. The galaxy in this case is fainter: V = 22.7 +/- 0.05, R = 22.25 +/- 0...

  16. GRB 051022: Physical Parameters and Extinction of a Prototype Dark Burst

    NARCIS (Netherlands)

    Rol, E.; van der Horst, A.; Wiersema, K.; Patel, S.K.; Levan, A.; Nysewander, M.; Kouveliotou, C.; Wijers, R.A.M.J.; Tanvir, N.; Reichart, D.; Fruchter, A.S.; Graham, J.; Ovaldsen, J.-E.; Jaunsen, A.O.; Jonker, P.G.; van der Ham, W.; Hjorth, J.; Starling, R.L.C.; O'Brien, P.T.; Fynbo, J.; Burrows, D.N.; Strom, R.

    2007-01-01

    GRB 051022 was undetected to deep limits in early optical observations, but precise astrometry from radio and X-rays showed that it most likely originated in a galaxy at z~0.8. We report radio, optical, near-infrared, and X-ray observations of GRB 051022. Using the available X-ray and radio data, we

  17. The Ultra-Fast Flash Observatory’s space GRB mission and science

    DEFF Research Database (Denmark)

    Lim, H.; Ahmad, S.; Barrillon, P.

    2012-01-01

    Abstract. The Ultra-Fast Flash Observatory (UFFO) is a space mission to detect the early moments of an explosion from Gamma-ray bursts (GRBs), thus enhancing our understanding of the GRB mechanism. It consists of the UFFO Burst & Trigger telescope (UBAT) for the recognition of GRB positions using...

  18. The Enigma of the Strong MgII Absorbers along the GRB Sightlines

    Science.gov (United States)

    Cucchiara, Antonino; Charlton, J.; Jones, T.; Fox, D. B.; Narayan, A.; Narayan, A.

    2009-01-01

    The startling result of Prochter & Prochaska (2006) that the incidence of strong MgII absorbers (equivalent width EW(2796Å) > 1 Å) along gamma-ray burst (GRB) sightlines is four times larger (dN/dzGR=0.90) than for quasar sightlines (dN/dzQSO=0.24) has yet to be understood. In particular, explanations relating to dust bias in quasar samples, partial covering of quasars, and lensing amplification of the GRB beam all fail to satisfy basic observational constraints. We are currently engaged in an effort to explore this mystery using archival VLT/UVES (R=45,000) quasar and afterglow spectra. Identifying strong MgII absorbers in a uniform and statistically complete manner, we have compiled a sample of 28 absorbers toward 81 quasars and 9 absorbers toward 6 GRB afterglows. We explore the kinematics of the absorbers, the abundances of other metal species, and the strength of dust depletion in the GRB and QSO samples. We fail to identify any respects in which 75% of the GRB line-of-sight absorbers can be distinguished from the other members of the GRB and QSO absorber populations. We consider whether this finding rules out the possibility of an intrinsic high-velocity (v 0.2 c) GRB or GRB host-related origin for the excess absorbers, and conclude that it does not.

  19. Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation.

    Science.gov (United States)

    Mokbel, Nancy; Hoffman, Nolan J; Girgis, Christian M; Small, Lewin; Turner, Nigel; Daly, Roger J; Cooney, Gregory J; Holt, Lowenna J

    2014-11-01

    Grb10 is an intracellular adaptor protein which binds directly to several growth factor receptors, including those for insulin and insulin-like growth factor receptor-1 (IGF-1), and negatively regulates their actions. Grb10-ablated (Grb10(-/-) ) mice exhibit improved whole body glucose homeostasis and an increase in muscle mass associated specifically with an increase in myofiber number. This suggests that Grb10 may act as a negative regulator of myogenesis. In this study, we investigated in vitro, the molecular mechanisms underlying the increase in muscle mass and the improved glucose metabolism. Primary muscle cells isolated from Grb10(-/-) mice exhibited increased rates of proliferation and differentiation compared to primary cells isolated from wild-type mice. The improved proliferation capacity was associated with an enhanced phosphorylation of Akt and ERK in the basal state and changes in the expression of key cell cycle progression markers involved in regulating transition of cells from the G1 to S phase (e.g., retinoblastoma (Rb) and p21). The absence of Grb10 also promoted a faster transition to a myogenin positive, differentiated state. Glucose uptake was higher in Grb10(-/-) primary myotubes in the basal state and was associated with enhanced insulin signaling and an increase in GLUT4 translocation to the plasma membrane. These data demonstrate an important role for Grb10 as a link between muscle growth and metabolism with therapeutic implications for diseases, such as muscle wasting and type 2 diabetes.

  20. Multiwavelength analysis of the intriguing GRB 061126: The reverse shock scenario and magnetization

    NARCIS (Netherlands)

    Gomboc, A.; Kobayashi, S.; Guidorzi, C.; Melandri, A.; Mangano, V.; Sbarufatti, B.; Mundell, C.G.; Schady, P.; Smith, R.J.; Updike, A.C.; Kann, D.A.; Misra, K.; Rol, E.; Pozanenko, A.; Castro-Tirado, A.J.; Anupama, G.C.; Bersier, D.; Bode, M.F.; Carter, D.; Curran, P.; Fruchter, A.; Graham, J.; Hartmann, D.H.; Ibrahimov, M.; Levan, A.; Monfardini, A.; Mottram, C.J.; O'Brien, P.T.; Prema, P.; Sahu, D.K.; Steele, I.A.; Tanvir, N.R.; Wiersema, K.

    2008-01-01

    We present a detailed study of the prompt and afterglow emission from Swift GRB 061126 using BAT, XRT, UVOT data and multicolor optical imaging from 10 ground-based telescopes. GRB 061126 was a long burst (T90 = 191 s) with four overlapping peaks in its γ-ray light curve. The X-ray afterglow, observ

  1. The X-Ray, optical, and infrared counterpart to GRB 980703

    NARCIS (Netherlands)

    Vreeswijk, P.M.; Galama, T.J.; Owens, A.; Oosterbroek, T.; Geballe, T.R.; van Paradijs, J.; Groot, P.J.; Kouveliotou, C.; Wijers, R.A.M.J.

    1999-01-01

    We report on X-ray, optical, and infrared follow-up observations of GRB 980703. We detect a previously unknown X-ray source in the GRB error box; assuming a power-law decline, we find for its decay index alpha<-0.91 (3 sigma). We invoke host-galaxy extinction to match the observed spectral slope wit

  2. On the jet structure and magnetic field configuration of GRB 020813

    NARCIS (Netherlands)

    Lazzati, D.; Covino, S.; Gorosabel, J.; Rossi, E.; Ghisellini, G.; Rol, E.; Castro Cerón, J.M.; Castro-Tirado, A.J.; Della Valle, M.; di Serego Alighieri, S.; Fruchter, A.S.; Fynbo, J.P.U.; Goldoni, P.; Hjorth, J.; Israel, G.L.; Kaper, L.; Kawai, N.; Le Floc'h, E.; Malesani, D.; Mazzali, P.; Mirabel, F.; Møller, P.; Ortolani, S.; Palazzi, E.; Pian, E.; Rhoads, J.; Ricker, G.; Salmonson, J.D.; Stella, L.; Tagliaferri, G.; Tanvir, N.; van den Heuvel, E.; Wijers, R.A.M.J.; Zerbi, F.M.

    2004-01-01

    The polarization curve of GRB 020813 is discussed and compared to different models for the structure, evolution and magnetisation properties of the jet and the interstellar medium onto which the fireball impacts. GRB 020813 is best suited for this kind of analysis for the smoothness of its afterglow

  3. A multi-colour study of the dark GRB 000210 host galaxy and its environment

    DEFF Research Database (Denmark)

    Gorosabel, J.; Christensen, Lise; Hjorth, J.;

    2003-01-01

    We present UBVRIZJsHKs broad band photometry of the host galaxy of the dark gamma-ray burst (GRB) of February 10, 2000. These observations represent the most exhaustive photometry given to date of any GRB host galaxy. A grid of spectral templates have been fitted to the Spectral Energy Distributi...

  4. Constraints on Short Gamma-Ray Burst Models with Optical Limits of GRB 050509b

    Energy Technology Data Exchange (ETDEWEB)

    Hjorth, Jens; Sollerman, J.; Gorosabel, J.; Granot, J.; Klose, S.; Kouveliotou, C.; Melinder, J.; Ramirez-Ruiz, E.; Starling, R.; Thomsen, B.; Andersen, M.I.; Fynbo,; Jensen, B.L.; Vreeswijk, P.M.; Castro-Ceron, J.M.; Jakobsson, P.; Levan, A.; Pedersen, K.; Rhoads, J.E.; Tanvir, N.R.; Watson, D.; /Bohr Inst. /Stockholm U. /IAA, Granada

    2005-06-15

    We have obtained deep optical images with the Very Large Telescope at ESO of the first well-localized short-duration gamma-ray burst, GRB 050509b. We observed in the V and R bands at epochs starting at {approx}2 days after the GRB trigger and lasting up to three weeks. We detect no variable objects inside the small Swift/XRT X-ray error circle down to 5{sigma} limiting magnitudes of V = 26.5 and R = 25.2. The X-ray error circle includes a giant elliptical galaxy at z = 0.225, which has been proposed as the likely host of this GRB. Our limits indicate that if the GRB originated at z = 0.225, any supernova-like event accompanying the GRB would have to be over 100 times fainter than normal Type Ia SNe or Type Ic hypernovae, 5 times fainter than the faintest known Ia or Ic SNe, and fainter than the faintest known Type II SNe. Moreover, we use the optical limits to constrain the energetics of the GRB outflow, and conclude that there was very little radioactive material produced during the GRB explosion. These limits strongly constrain progenitor models for this short GRB.

  5. Limits on the Transient Ultra-High Energy Neutrino Flux from Gamma-Ray Bursts (GRB) Derived from RICE Data

    CERN Document Server

    Hussain, S; al, et

    2006-01-01

    We present limits on ultra-high energy (UHE; E(nu)>1 PeV) neutrino fluxes from gamma-ray bursts (GRB), based on recently presented data, limits, and simulations from the RICE experiment. We use data from five recorded transients with sufficient photon spectral shape and redshift information to derive an expected neutrino flux, assuming that the observed photons are linked to neutrino production through pion decay via the well-known 'Waxman-Bahcall' prescription. Knowing the declination of the observed burst, as well as the RICE sensitivity as a function of polar angle and the previously published non-observation of any neutrino events allows an estimate of the sensitivity to a given neutrino flux. Although several orders of magnitude weaker than the expected fluxes, our GRB neutrino flux limits are nevertheless the first in the PeV--EeV energy regime. For completeness, we also provide a listing of other bursts, recorded at times when the RICE experiment was active, but requiring some assumptions regarding lum...

  6. The spatially resolved host of GRB 060505 and implications for the nature of the progenitor

    CERN Document Server

    Thoene, Christina C

    2007-01-01

    We present a study of the host galaxy of the Gamma-Ray Burst (GRB) of May 5 2006 (GRB 060505). The host is spatially resolved in both imaging data and in a long slit spectrum including the GRB site. We find the galaxy to be a Sbc spiral, which is unusual for a long GRB host galaxy. The site of the GRB is considerably different from the rest of the galaxy with intense star formation, low metallicity and a young age. This suggest a massive stellar progenitor rather than a merger of compact objects which has been suggested based on the the relatively short duration of T_90=4s for the prompt emission.

  7. MASTER-OAFA: Fermi GRB faded optical counterpart detection

    Science.gov (United States)

    Pogrosheva, T.; Lipunov, V.; Podesta, R.; Levato, H.; Buckley, D.; Gorbovskoy, E.; Tiurina, N.; Balanutsa, P.; Kuznetsov, A.; Gress, O.; Kornilov, V.; Vladimirov, V.; Chazov, V.; Gorbunov, I.; Krylov, A.; Shumkov, V.; Kuvshinov, D.

    2017-02-01

    During Fermi GBM 508295323 trigger ( GRB_TIME: 2017-02-09 01:08:38.08 UT https://gcn.gsfc.nasa.gov/other/508295323.fermi ) inspection MASTER-OAFA auto-detection system ( Lipunov et al., "MASTER Global Robotic Net", Advances in Astronomy, 2010, 30L ) discovered new OT source (Podesta et al. GCN #20650) at (RA, Dec) = 07h 23m 07.30s -52d 14m 46.6s on 2017-02-09 02:07:07.478UT with unfiltered m_OT=17.4 (mlimit=18.1m).

  8. Light speed variation from gamma ray burst GRB 160509A

    CERN Document Server

    Xu, Haowei

    2016-01-01

    It is postulated in Einstein's relativity that the speed of light in vacuum is a constant for all observers. However, the effect of quantum gravity could bring an energy dependence of light speed. Even a tiny speed variation, when amplified by the cosmological distance, may be revealed by the observed time lags between photons with different energies from astrophysical sources. From the newly detected long gamma ray burst GRB~160509A, we find evidence to support the prediction for a linear form modification of light speed in cosmological space.

  9. Light speed variation from gamma ray burst GRB 160509A

    Directory of Open Access Journals (Sweden)

    Haowei Xu

    2016-09-01

    Full Text Available It is postulated in Einstein's relativity that the speed of light in vacuum is a constant for all observers. However, the effect of quantum gravity could bring an energy dependence of light speed. Even a tiny speed variation, when amplified by the cosmological distance, may be revealed by the observed time lags between photons with different energies from astrophysical sources. From the newly detected long gamma ray burst GRB 160509A, we find evidence to support the prediction for a linear form modification of light speed in cosmological space.

  10. A Characteristic Wind Signature in Prompt GRB Afterglows

    CERN Document Server

    Kobayashi, S; Zhang, B; Kobayashi, Shiho; Meszaros, Peter; Zhang, Bing

    2004-01-01

    We discuss the self-absorption effects in the prompt emission from the reverse shock in GRB afterglows that occur in the wind environment of a massive stellar progenitor. We point out that the higher self-absorption frequency in a wind environment implies a hump in the reverse shock emission spectrum and a more complex optical/IR light curve behavior than previously thought. We discuss a possible new diagnostic to test for the presence of a wind environment, and to provide constraints on the progenitor wind mass loss and the burst parameters.

  11. The Afterglow and Environment of the Short GRB111117A

    CERN Document Server

    Margutti, R; Fong, W; Zauderer, B A; Cenko, S B; Greiner, J; Soderberg, A M; Cucchiara, A; Klose, S; Rossi, A; Schmidl, S; Milisavljevic, D; Sanders, N

    2012-01-01

    We present multi-wavelength observations of the afterglow of the short GRB111117A, and follow-up observations of its host galaxy. From rapid optical and radio observations we place limits of r \\gtrsim 25.5 mag at \\deltat \\approx 0.55 d and F_nu(5.8 GHz) 3-10 degrees (depending on the circumburst density). We conclude that Chandra observations of short GRBs are effective at determining precise positions and robust host galaxy associations in the absence of optical and radio detections.

  12. Light speed variation from gamma ray burst GRB 160509A

    Science.gov (United States)

    Xu, Haowei; Ma, Bo-Qiang

    2016-09-01

    It is postulated in Einstein's relativity that the speed of light in vacuum is a constant for all observers. However, the effect of quantum gravity could bring an energy dependence of light speed. Even a tiny speed variation, when amplified by the cosmological distance, may be revealed by the observed time lags between photons with different energies from astrophysical sources. From the newly detected long gamma ray burst GRB 160509A, we find evidence to support the prediction for a linear form modification of light speed in cosmological space.

  13. The bright optical afterglow of the long GRB 001007

    DEFF Research Database (Denmark)

    Ceron, J.M.C.; Castro-Tirado, A.J.; Gorosabel, J.

    2002-01-01

    We present optical follow up observations of the long GRB 001007 between 6.14 hours and similar to468 days after the event. An unusually bright optical afterglow (OA) was seen to decline following a steep power law decay with index alpha = -2.03 +/- 0.11, possibly indicating a break in the light...... curve at t - t(0) ray event provide tentative (1.2σ) evidence for a break in the optical light curve. The spectral index β of the OA yields -1.24 +/- 0.57. These values may be explained both...

  14. Review of the efficacy of individualized chemotherapy selected by in vitro drug sensitivity testing for patients with cancer.

    Science.gov (United States)

    Cortazar, P; Johnson, B E

    1999-05-01

    The purpose of this study is to review the potential efficacy of individualized chemotherapy selected by in vitro drug sensitivity testing (DST) compared with empiric regimens for patients with cancer. MEDLINE and CANCERLIT were searched for articles published (in English) about prospective clinical trials in which patients were treated with chemotherapy that was selected with the use of in vitro DST. We identified 12 prospective studies that examined the benefit of chemotherapy selected by DST. Five hundred six patients (33%) were treated with chemotherapy that was selected with the use of in vitro DST. The mean response rate for patients treated with in vitro-selected therapy was 27% (range, 10% to 100%; n = 12 studies) compared with 18% (range, 0% to 100%; n = 7 studies) for patients treated with empiric therapy. Five studies (only one randomized) evaluated the impact of chemotherapy selected by in vitro DST on patient survival. Three studies showed that survival was 1 to 4 months longer for the 238 patients treated with empiric chemotherapy compared with that of the 65 patients treated with chemotherapy that was selected by in vitro testing. Two nonrandomized studies showed that survival was 4 or 19 months longer for 27 patients treated with chemotherapy selected by in vitro testing compared with that of 80 patients who were treated with empiric chemotherapy. Only one third of patients entered in prospective trials of in vitro DST were actually treated with an in vitro best regimen. The response rates seem to be better with in vitro selected chemotherapy regimens than with empiric regimens, but the impact on survival has not been adequately addressed.

  15. First GRB detections with the AGILE Minicalorimeter

    Science.gov (United States)

    Marisaldi, M.; Labanti, C.; Fuschino, F.; Galli, M.; Tavani, M.; Bulgarelli, A.; Gianotti, F.; Trifoglio, M.; Argan, A.

    2008-05-01

    The Minicalorimeter (MCAL) onboard the AGILE satellite is a 1400 cm2 scintillation detector sensitive in the energy range 0.3-200 MeV. MCAL works both as a slave of the AGILE Silicon Tracker and as an autonomous detector for transient events (BURST mode). A dedicated onboard Burst Search logic scans BURST mode data in search of count rate increase. Peculiar characteristics of the detector are the high energy spectral coverage and a timing resolution of about 2 microseconds. Even if a trigger is not issued, BURST mode data are used to build a broad band energy spectrum (scientific ratemeters) organized in 11 bands for each of the two MCAL detection planes, with a time resolution of 1 second. After the first engineering commissioning phase, following the AGILE launch on 23rd April 2007, between 22nd June and 5th November 2007 eighteen GRBs were detected offline in the scientific ratemeters data, with a detection rate of about one per week. In this paper the capabilities of the detector will be described and an overview of the first detected GRBs will be given.

  16. GRB beaming and gravitational-wave observations

    CERN Document Server

    Chen, Hsin-Yu

    2012-01-01

    Using the observed rate of short-duration gamma-ray bursts (GRBs) it is possible to make predictions for the detectable rate of compact binary coalescences in gravitational-wave detectors. These estimates rely crucially on the growing consensus that short gamma-ray bursts are associated with the merger of two neutron stars or a neutron star and a black hole, but otherwise make no assumptions beyond the observed rate of short GRBs. In particular, our results do not assume coincident gravitational wave and electromagnetic observations. We show that the non-detection of mergers in the existing LIGO/Virgo data constrains the progenitor masses and beaming angles of gamma-ray bursts. For future detectors, we find that the first detection of a NS-NS binary coalescence associated with the progenitors of short GRBs is likely to happen within the first 16 months of observation, even in the case of a modest network of observatories (e.g., only LIGO-Hanford and LIGO-Livingston) operating at modest sensitivities (e.g., ad...

  17. SN 2013dx associated with GRB 130702A: a detailed photometric and spectroscopic monitoring and a study of the environment

    Science.gov (United States)

    D'Elia, V.; Pian, E.; Melandri, A.; D'Avanzo, P.; Della Valle, M.; Mazzali, P. A.; Piranomonte, S.; Tagliaferri, G.; Antonelli, L. A.; Bufano, F.; Covino, S.; Fugazza, D.; Malesani, D.; Møller, P.; Palazzi, E.

    2015-05-01

    Aims: Long-duration gamma-ray bursts (GRBs) and broad-line, type Ic supernovae (SNe) are strongly connected. We aim at characterizing SN 2013dx, which is associated with GRB 130702A, through a sensitive and extensive ground-based observational campaign in the optical-IR band. Methods: We monitored the field of the Swift GRB 130702A (redshift z = 0.145) using the 8.2 m VLT, the 3.6 m TNG and the 0.6 m REM telescopes during the time interval between 4 and 40 days after the burst. Photometric and spectroscopic observations revealed the associated type Ic SN 2013dx. Our multiband photometry allowed constructing a bolometric light curve. Results: The bolometric light curve of SN 2013dx resembles that of 2003dh (associated with GRB 030329), but is ~10% faster and ~25% dimmer. From this we infer a synthesized 56Ni mass of ~0.2 M⊙. The multi-epoch optical spectroscopy shows that the SN 2013dx behavior is best matched by SN 1998bw, among the other well-known low-redshift SNe associated with GRBs and XRFs, and by SN 2010ah, an energetic type Ic SN not associated with any GRB. The photospheric velocity of the ejected material declines from ~2.7 × 104 km s-1 at 8 rest frame days from the explosion, to ~3.5 × 103 km s-1 at 40 days. These values are extremely close to those of SN1998bw and 2010ah. We deduce for SN 2013dx a kinetic energy of ~35 × 1051 erg and an ejected mass of ~7 M⊙. This suggests that the progenitor of SN2013dx had a mass of ~25-30 M⊙, which is 15-20% less massive than that of SN 1998bw. Finally, we studied the SN 2013dx environment through spectroscopy of the closeby galaxies: 9 out of the 14 inspected galaxies lie within 0.03 in redshift from z = 0.145, indicating that the host of GRB 130702A/SN 2013dx belongs to a group of galaxies, an unprecedented finding for a GRB-associated SN and, to our knowledge, for long GRBs in general. Based on observations collected at the Italian 3.6-m Telescopio Nazionale Galileo (TNG), operated on the island of La

  18. An optical study of the GRB 970111 field beginning 19 hours after the gamma-ray burst

    DEFF Research Database (Denmark)

    Gorosabel, J.; Castro-Tirado, A.J.; Wolf, Christian

    1998-01-01

    We present the results of the monitoring of the GRB 970111 field that started 19 hours after the event. This observation represents the fastest ground-based follow-up performed for GRB 970111 in all wavelengths. As soon as the detection of the possible GRB 970111 X-ray afterglow was reported...... by Feroci et al. (1998) we reanalyzed the optical data collected for the GRB 970111 field. Although we detect small magnitude variability in some objects, no convincing optical counterpart is found inside the WFC error box. Any change in brightness 19 hours after the GRB is less than 0.2 mag for objects...... multicolour photometry for objects in the GRB 970111 error box. The colour-colour diagrams do not show any object with unusual colours. We applied a photometric classification method to the objects inside the GRB error box, that can distinguish stars from galaxies and estimate redshifts. We were able...

  19. Grb2 is regulated by foxd3 and has roles in preventing accumulation and aggregation of mutant huntingtin.

    Directory of Open Access Journals (Sweden)

    Shounak Baksi

    Full Text Available Growth factor receptor protein binding protein 2 (Grb2 is known to be associated with intracellular growth and proliferation related signaling cascades. Huntingtin (Htt, a ubiquitously expressed protein, when mutated, forms toxic intracellular aggregates - the hallmark of Huntington's disease (HD. We observed an elevated expression of Grb2 in neuronal cells in animal and cell models of HD. Grb2 overexpression was predominantly regulated by the transcription factor Forkhead Box D3 (Foxd3. Exogenous expression of Grb2 also reduced aggregation of mutant Htt in Neuro2A cells. Grb2 is also known to interact with Htt, depending on epidermal growth factor receptor (EGFR activation. Grb2- mutant Htt interaction in the contrary, took place in vesicular structures, independent of EGFR activation that eventually merged with autophagosomes and activated the autophagy machinery helping in autophagosome and lysosome fusion. Grb2, with its emerging dual role, holds promise for a survival mechanism for HD.

  20. Discovery of GRB 020405 and its Underlying Supernova

    CERN Document Server

    Price, P A; Berger, E; Fox, D W; Bloom, J S; Djorgovski, S G; Frail, D A; Galama, T J; Harrison, F A; McCarthy, P; Reichart, D E; Sari, R; Yost, S A; Jerjen, H; Flint, K; Phillips, A; Warren, B E; Axelrod, T S; Chevalier, R A; Halpern, J P; Holtzmann, J A; Kimble, R A; Schmidt, B P; Wheeler, J C; Frontera, F; Costa, E; Piro, L; Hurley, K; Cline, T; Guidorzi, C; Montanari, E; Mazets, E; Golenetskii, S V; Mitrofanov, I G; Anfimov, D; Kozyrev, A B; Litvak, M; Sanin, A; Boynton, W; Fellows, C; Harshman, K; Shinohara, C; Gal-Yam, A; Ofek, E O; Lipkin, Yu M

    2002-01-01

    We present the discovery of GRB 020405 made with the Inter-Planetary Network (IPN). With a duration of 60 s, the burst appears to be a typical long duration event. We observed the 75-square acrminute IPN error region with the Mount Stromlo Observatory's 50-inch robotic telescope and discovered a transient source which subsequently decayed and was also associated with a variable radio source. We identify this source as the afterglow of GRB 020405. Subsequent observations by other groups found varying polarized flux and established a redshift of 0.690 to the host galaxy. Motivated by the low redshift we triggered observations with WFPC2 on-board the Hubble Space Telescope (HST). Modeling the early ground-based data with a jet model, we find a clear red excess over the decaying optical lightcurves that is present between day 10 and day 50 (the last HST epoch). This "bump" has the spectral and temporal features expected of an underlying supernova (SN). In particular, the red color of the putative SN is similar to...

  1. Off-Axis Neutrino Scattering in GRB Central Engines

    CERN Document Server

    George, N D; McGhee, J M; Miller, W A; George, Nathan D.; Kheyfets, Arkady; Ghee, John M. Mc; Miller, Warner A.

    2003-01-01

    The search for an understanding of an energy source great enough to explain the gamma-ray burst (GRB) phenomena has attracted much attention from the astrophysical community since its discovery. In this paper we extend the work of K. Asano and T. Fukuyama, and J. D. Salmonson and J. R. Wilson, and analyze the off-axis contributions to the energy-momentum deposition rate (MDR) from the neutrino anti-neutrino collisions above a rotating black hole/thin accretion disk system. Our calculations are performed by imaging the accretion disk at a specified observer using the full geodesic equations, and calculating the cumulative MDR from the scattering of all pairs of neutrinos and anti-neutrinos arriving at the observer. Our results shed light on the beaming efficiency of GRB models of this kind. Although we confirm Asano and Fukuyama's conjecture as to the constancy of the beaming for small angles away from the axis; nevertheless, we find the dominant contribution to the MDR comes from near the surface of the disk ...

  2. GAME: Grb and All-sky Monitor Experiment

    CERN Document Server

    Amati, L; Frontera, F; Labanti, C; Feroci, M; Hudec, R; Gomboc, A; Ruffini, R; Santangelo, A; Vacchi, A; Campana, R; Evangelista, Y; Fuschino, F; Salvaterra, R; Stratta, G; Tagliaferri, G; Guidorzi, C; Rosati, P; Titarchuk, L; Penacchioni, A; Izzo, L; Zampa, N; Rodic, T

    2014-01-01

    We describe the GRB and All-sky Monitor Experiment (GAME) mission submitted by a large international collaboration (Italy, Germany, Czech Repubblic, Slovenia, Brazil) in response to the 2012 ESA call for a small mission opportunity for a launch in 2017 and presently under further investigation for subsequent opportunities. The general scientific objective is to perform measurements of key importance for GRB science and to provide the wide astrophysical community of an advanced X-ray all-sky monitoring system. The proposed payload was based on silicon drift detectors (~1-50 keV), CdZnTe (CZT) detectors (~15-200 keV) and crystal scintillators in phoswich (NaI/CsI) configuration (~20 keV-20 MeV), three well established technologies, for a total weight of ~250 kg and a required power of ~240 W. Such instrumentation allows a unique, unprecedented and very powerful combination of large field of view (3-4 sr), a broad energy energy band extending from ~1 keV up to ~20 MeV, an energy resolution as good as ~300 eV in ...

  3. The dark nature of GRB 051022 and its host galaxy

    CERN Document Server

    Castro-Tirado, A J; McBreen, S; Gorosabel, J; Guziy, S; Delgado, R M Gonzalez; Bihain, G; Fakthullin, T; Pandey, S B; Jelinek, M; Postigo, A de Ugarte; Sokolov, V; Misra, K; Sagar, R; Bama, P; Kamble, A P; Anupama, G C; Licandro, J; Aceituno, F J; Neri, R

    2007-01-01

    We present multiwavelength (X-ray/optical/near-infrared/millimetre) observations of GRB 051022 between 2.5 hours and ~1.15 yr after the event. It is the most intense gamma-ray burst (~ 10^-4 erg cm^-2) detected by HETE-2, with the exception of the nearby GRB 030329. Optical and near infrared observations did not detect the afterglow despite a strong afterglow at X-ray wavelengths. Millimetre observations at Plateau de Bure (PdB) detected a source and a flare, confirming the association of this event with a moderately bright (R = 21.5) galaxy. Spectroscopic observations of this galaxy show strong [O II], Hbeta and [O III] emission lines at a redshift of 0.809. The spectral energy distribution of the galaxy implies Av (rest frame) = 1.0 and a starburst occuring ~ 25 Myr ago, during which the star-forming-rate reached >= 25 Msun/yr. In conjunction with the spatial extent (~ 1'') it suggests a very luminous (Mv = - 21.8) blue compact galaxy, for which we also find with Z Zsun. The X-ray spectrum shows evidence of...

  4. Early afterglow detection in the Swift observations of GRB 050801

    CERN Document Server

    De Pasquale, M; Page, M J; Burrows, D N; Blustin, A J; Zane, S; Mason, K O; Roming, P W A; Palmer, D; Gehrels, N; Zhang, B; Pasquale, Massimiliano De

    2007-01-01

    We present results of Swift optical, UV and X-ray observations of the afterglow of GRB 050801. The source is visible over the full optical, UV and X-ray energy range of the Swift UVOT and XRT instruments.Both optical and X-ray lightcurves exhibit a broad plateau (\\Delta t/t ~ 1) during the first few hundred seconds after the gamma-ray event. We investigate the multiwavelength spectral and timing properties of the afterglow, and we suggest that the behaviour at early times is compatible with an energy injection by a newly born magnetar with a period of a few tenths of a millisecond, which keeps the forward shock refreshed over this short interval by irradiation. Reverse shock emission is not observed. Its suppression might be due to GRB ejecta being permeated by high magnetic fields, as expected for outflows powered by a magnetar.Finally, the multiwavelength study allows a determination of the burst redshift, z=1.56.

  5. GRB cosmology through the Ep,i-intensity correlation

    Science.gov (United States)

    Amati, L.; Sawant, D. S.; Della Valle, M.

    Despite they are not standard candles, the investigation of Gamma-Ray Bursts (GRBs) as a tool for measuring the geometry and expansion rate of the Universe is strongly motivated by their unique combination of huge luminosity, up to more than 10/53 erg/s, with a redshift distribution extending up to more than z = 9. In recent years, several attempts to exploit the correlation between the photon energy at which the vFv spec- trum peaks (peak energy) and the radiated energy (or luminosity) for standardizing GRBs and using them to estimate cosmological parameters have been made. These studies show that already with the present data-set, GRBs can provide a significant and independent confirmation of ΛM ˜ 0.3 for a flat ΛCDM. The investigation of the correlation of Ep,i with different intensity indicators (e.g., radiated energy, average and peak luminosity, bolometric vs. monochromatic quantities, etc.) both in terms of intrinsic dispersion of and accuracy for estimating ΛM further confirms its reliability and effectiveness for both GRB physics and their standardization for cosmology. Current (e.g., Swift, Fermi/GBM, Konus-WIND) and forthcoming GRB experiments (e.g., CALET/GBM, SVOM, Lomonosov/UFFO) will allow us to constrain ΛM with an accuracy comparable to that currently exhibited by Type Ia supernovae and to study the properties of dark energy and their evolution with time.

  6. Statistical significance of spectral lag transition in GRB 160625B

    Science.gov (United States)

    Ganguly, Shalini; Desai, Shantanu

    2017-09-01

    Recently Wei et al.[1] have found evidence for a transition from positive time lags to negative time lags in the spectral lag data of GRB 160625B. They have fit these observed lags to a sum of two components: an assumed functional form for intrinsic time lag due to astrophysical mechanisms and an energy-dependent speed of light due to quadratic and linear Lorentz invariance violation (LIV) models. Here, we examine the statistical significance of the evidence for a transition to negative time lags. Such a transition, even if present in GRB 160625B, cannot be due to an energy dependent speed of light as this would contradict previous limits by some 3-4 orders of magnitude, and must therefore be of intrinsic astrophysical origin. We use three different model comparison techniques: a frequentist test and two information based criteria (AIC and BIC). From the frequentist model comparison test, we find that the evidence for transition in the spectral lag data is favored at 3.05σ and 3.74σ for the linear and quadratic models respectively. We find that ΔAIC and ΔBIC have values ≳ 10 for the spectral lag transition that was motivated as being due to quadratic Lorentz invariance violating model pointing to ;decisive evidence;. We note however that none of the three models (including the model of intrinsic astrophysical emission) provide a good fit to the data.

  7. GRB-supernovae: a new spin on gravitational waves

    CERN Document Server

    Van Putten, M H P M

    2005-01-01

    The discovery of the GRB-supernova association poses the question on the nature of the inner engine as the outcome of Type Ib/c supernovae. These events are believed to represent core-collapse of massive stars, probably in low-period stellar binaries and similar but not identical to the Type II event SN1987A. The branching ratio of Type Ib/c supernovae into GRB-supernovae has the remarkably small value of less than 0.5%. These observational constraints point towards a rapidly rotating black hole formed at low probability with low kick velocity. The putative black hole hereby remains centered, and matures into a high-mass object with large rotational energy in angular momentum. As the MeV-neutrino emissions from SN1987A demonstrate, the most powerful probe of the inner workings of core-collapse events are radiation channels to which the remnant envelope is optically thin. We here discuss the prospect of gravitational-wave emissions powered by a rapidly rotating central black hole which, in contrast to MeV-neut...

  8. IceCube and GRB neutrinos propagating in quantum spacetime

    Directory of Open Access Journals (Sweden)

    Giovanni Amelino-Camelia

    2016-10-01

    Full Text Available Two recent publications have reported intriguing analyses, tentatively suggesting that some aspects of IceCube data might be manifestations of quantum-gravity-modified laws of propagation for neutrinos. We here propose a strategy of data analysis which has the advantage of being applicable to several alternative possibilities for the laws of propagation of neutrinos in a quantum spacetime. In all scenarios here of interest one should find a correlation between the energy of an observed neutrino and the difference between the time of observation of that neutrino and the trigger time of a GRB. We select accordingly some GRB-neutrino candidates among IceCube events, and our data analysis finds a rather strong such correlation. This sort of study naturally lends itself to the introduction of a “false alarm probability”, which for our analysis we estimate conservatively to be of 1%. We therefore argue that our findings should motivate a vigorous program of investigation following the strategy here advocated.

  9. MAGIC upper limits on the GRB 090102 afterglow

    CERN Document Server

    Aleksić, J; Antonelli, L A; Antoranz, P; Babic, A; Bangale, P; de Almeida, U Barres; Barrio, J A; González, J Becerra; Bednarek, W; Berger, K; Bernardini, E; Biland, A; Blanch, O; Bock, R K; Bonnefoy, S; Bonnoli, G; Borracci, F; Bretz, T; Carmona, E; Carosi, A; Fidalgo, D Carreto; Colin, P; Colombo, E; Contreras, J L; Cortina, J; Covino, S; Da Vela, P; Dazzi, F; De Angelis, A; De Caneva, G; De Lotto, B; Mendez, C Delgado; Doert, M; Domínguez, A; Prester, D Dominis; Dorner, D; Doro, M; Einecke, S; Eisenacher, D; Elsaesser, D; Farina, E; Ferenc, D; Fonseca, M V; Font, L; Frantzen, K; Fruck, C; López, R J García; Garczarczyk, M; Terrats, D Garrido; Gaug, M; Giavitto, G; Godinović, N; Muñoz, A González; Gozzini, S R; Hadasch, D; Hayashida, M; Herrero, A; Hildebrand, D; Hose, J; Hrupec, D; Idec, W; Kadenius, V; Kellermann, H; Knoetig, M L; Kodani, K; Konno, Y; Krause, J; Kubo, H; Kushida, J; La Barbera, A; Lelas, D; Lewandowska, N; Lindfors, E; Lombardi, S; López, M; López-Coto, R; López-Oramas, A; Lorenz, E; Lozano, I; Makariev, M; Mallot, K; Maneva, G; Mankuzhiyil, N; Mannheim, K; Maraschi, L; Marcote, B; Mariotti, M; Martínez, M; Mazin, D; Menzel, U; Meucci, M; Miranda, J M; Mirzoyan, R; Moralejo, A; Munar-Adrover, P; Nakajima, D; Niedzwiecki, A; Nilsson, K; Nishijima, K; Nowak, N; Orito, R; Overkemping, A; Paiano, S; Palatiello, M; Paneque, D; Paoletti, R; Paredes, J M; Paredes-Fortuny, X; Partini, S; Persic, M; Prada, F; Moroni, P G Prada; Prandini, E; Preziuso, S; Puljak, I; Reinthal, R; Rhode, W; Ribó, M; Rico, J; Garcia, J Rodriguez; Rügamer, S; Saggion, A; Saito, T; Saito, K; Salvati, M; Satalecka, K; Scalzotto, V; Scapin, V; Schultz, C; Schweizer, T; Shore, S N; Sillanpää, A; Sitarek, J; Snidaric, I; Sobczynska, D; Spanier, F; Stamatescu, V; Stamerra, A; Steinbring, T; Storz, J; Sun, S; Surić, T; Takalo, L; Takami, H; Tavecchio, F; Temnikov, P; Terzić, T; Tescaro, D; Teshima, M; Thaele, J; Tibolla, O; Torres, D F; Toyama, T; Treves, A; Vogler, P; Wagner, R M; Zandanel, F; Zanin, R; Bouvier, A; Tajima, H; Longo, F

    2013-01-01

    Indications of a GeV component in the emission from GRBs are known since the EGRET observations during the 1990's and they have been confirmed by the data of the Fermi satellite. These results have, however, shown that our understanding of GRB physics is still unsatisfactory. The new generation of Cherenkov observatories and in particular the MAGIC telescope, allow for the first time the possibility to extend the measurement of GRBs from several tens up to hundreds of GeV energy range. Both leptonic and hadronic processes have been suggested to explain the possible GeV/TeV counterpart of GRBs. Observations with ground-based telescopes of very high energy photons (E>30 GeV) from these sources are going to play a key role in discriminating among the different proposed emission mechanisms, which are barely distinguishable at lower energies. MAGIC telescope observations of the GRB 090102 (z=1.547) field and Fermi Large Area Telescope (LAT) data in the same time interval are analysed to derive upper limits of the ...

  10. Early-Time Observations of the GRB 050319 Optical Transient

    CERN Document Server

    Quimby, R M; Yost, S A; Aharonian, F; Akerlof, C W; Alatalo, K; Ashley, M C B; Goegues, E; Guever, T; Horns, D; Kehoe, R L; Kiziloglu, U; McKay, T A; Oezel, M; Phillips, A; Schaefer, B E; Smith, D A; Swan, H F; Vestrand, W T; Wheeler, J C; Wren, J; Kiziloglu, Ue.

    2006-01-01

    We present the unfiltered ROTSE-III light curve of the optical transient associated with GRB 050319 beginning 4 s after the cessation of gamma-ray activity. We fit a power-law function to the data using the revised trigger time given by Chincarini et al. (2005), and a smoothly broken power-law to the data using the original trigger disseminated through the GCN notices. Including the RAPTOR data from Wozniak et al. (2005), the best fit power-law indices are alpha=-0.854 (+/- 0.014) for the single power-law and alpha_1=-0.364 (+/- 0.020), alpha_2= -0.881 (+/- 0.030), with a break at t_b = 418 (+/- 30) s for the smoothly broken fit. We discuss the fit results with emphasis placed on the importance of knowing the true start time of the optical transient for this multi-peaked burst. As Swift continues to provide prompt GRB locations, it becomes more important to answer the question, "when does the afterglow begin" to correctly interpret the light curves.

  11. GRB Probes of the High-z Universe with EXIST

    CERN Document Server

    Grindlay, Jonathan

    2009-01-01

    The Energetic X-ray Imaging Survey Telescope (EXIST) mission concept is optimized for study of high-z GRBs as probes of the early Universe. With a High Energy Telescope (HET) incorporating a 4.5m^2 5-600keV (CZT; 0.6mm pixels) detector plane for coded aperture imaging a 90deg x 70deg (>10% coding fraction) field of view with 2' resolution and 5 sigma sources, EXIST will perform rapid (7, EXIST will open a new era in studies of the early Universe as well as carry o ut a rich program of AGN and transient-source science. An overview of the GRB science objectives and a brief discussion of the overall mission design and operations is given, and example high-z GRB IRT spectra are shown. EXIST is being proposed to the Astro2010 Decadal Survey as a 5 year Medium Class mission that could be launched as early as 2017.

  12. Tracer-based quantification of individual frac discharge in single-well multiple-frac backflow: sensitivity study

    Science.gov (United States)

    Ghergut, Julia; Behrens, Horst; Sauter, Martin

    2014-05-01

    Within the deep-geothermal research project at GroßSchönebeck in the NE German Basin, targeting volcanic rocks (Lower Rotliegend) and siliciclastics (Upper Rotliegend) in the Lower Permian by means of a well doublet with several screening intervals between 3815 and 4247 m b.s.l., several artificial fractures with different geometric and hydraulic characteristics were created at each well, aiming to increase reservoir performance [1], [2]. It could not be told a priori which of the various fracturing treatments was to prove as most promising in terms of future reservoir productivity. At the intended-production well (GS-4), one large-area waterfrac was created in the low-permeability volcanic rocks, and two gel-proppant fractures in selected sandstone layers. Each fracturing treatment was accompanied by the injection of a water-dissolved tracer slug, followed by a defined volume of tracer-free ('chaser') fluid [3]. Each frac received a different species of a sulfonated aromatic acid salt, as a conservative water tracer. During subsequent backflow tests (either gas-based lifting, or production by means of a downhole submersible pump), each frac can contribute a certain (more or less constant) amount to the measured total discharge (also depending on whether and when each frac 'starts' contributing, and which effective aperture and area it actually 'manifests' during the process). Since these individual-frac discharge amounts cannot be measured directly, it was endeavoured to indirectly determine ('resolve') them from tracer signals as detectable in the overall backflow discharge. Therefore, we need to examine how these tracer signals depend on local discharge values and on local hydrogeologic parameters (matrix porosity, permeability distribution; frac transmissivity, thickness, effective area and aperture), and to what extent hydrogeological uncertainty will impede the inversion of local discharge values. To this end, a parameter sensitivity study was conducted on

  13. Prospects for GRB Polarimetry with GRAPE

    Science.gov (United States)

    McConnell, M. L.; Bloser, P. F.; Legere, J.; Macri, J. R.; Narita, T.; Ryan, J. M.

    2006-05-01

    This paper discusses the latest progress in the development of GRAPE (Gamma-Ray Polarimeter Experiment), a hard X-ray Compton Polarimeter. The purpose of GRAPE is to measure the polarization of hard X-rays in the 50-300 keV energy range. We are particularly interested in X-rays that are emitted from solar flares and gamma-ray bursts (GRBs). Accurately measuring the polarization of the emitted radiation from these sources will lead to a better understating of both the emission mechanisms and source geometries. The GRAPE design consists of an array of plastic scintillators surrounding a central high-Z crystal scintillator. We can monitor individual Compton scatters that occur in the plastics and determine whether the photon is photo absorbed by the high-Z crystal or not. A Compton scattered photon that is immediately photo absorbed by the high-Z crystal constitutes a valid event. These valid events provide us with the interaction locations of each incident photon and ultimately produces a modulation pattern for the Compton scattering of the polarized radiation. Comparing with Monte Carlo simulations of a 100% polarized beam, the level of polarization of the measured beam can then be determined. The complete array is mounted on a flat-panel multi-anode photomultiplier tube (MAPMT) that can measure the deposited energies resulting from the photon interactions. The design of the detector allows for a large field-of-view (> π steradian), at the same time offering the ability to be close-packed with multiple modules in order to reduce deadspace. We present in this paper the latest laboratory results obtained from GRAPE using partially polarized radiation sources along with a brief description of our future plans for the GRAPE design.

  14. Spatially resolved properties of the GRB 060505 host: implications for the nature of the progenitor

    CERN Document Server

    Thoene, C C; Oestlin, G; Milvang-Jensen, B; Wiersema, K; Malesani, D; Ferreira, D D M; Gorosabel, J; Kann, D A; Watson, D; Michalowski, M J; Hjorth, J; Fruchter, A S; Sollerman, J; Thoene, Christina C.; Fynbo, Johan P. U.; Oestlin, Goeran; Milvang-Jensen, Bo; Wiersema, Klaas; Malesani, Daniele; Ferreira, Desiree Della Monica; Gorosabel, Javier; Watson, Darach; Michalowski, Michal J.; Hjorth, Jens; Fruchter, Andrew S.; Sollerman, Jesper

    2007-01-01

    GRB 060505 was the first well-observed nearby long-duration GRB that had no associated supernova. Here we present spatially resolved spectra of the host galaxy of GRB 060505, an Sbc spiral, at redshift z=0.0889. The GRB occurred inside a star-forming region in the northern spiral arm at 6.5 kpc from the center. From the position of the emission lines, we determine a maximum rotational velocity for the galaxy of v ~ 212 km/s corresponding to a mass of 1.3x10^11 M_solar within 24 kpc. The Halpha equivalent width at the GRB site gives a very young age of <~ 7 Myr. By fitting single-age spectral synthesis models to the stellar continuum, we derive ages for the dominant stellar populations in different parts of the galaxy resulting in ~ 800 Myr for the bulge an only ~ 47 Myr for the GRB site. The metallicity derived from the R_23 parameter is lowest at the GRB site with 0.14 Z_solar but roughly solar in the rest of the galaxy. The extinction in the galaxy is overall low with A_V < 0.40 mag in the bulge and A...

  15. The host of the SN-less GRB 060505 in high resolution

    CERN Document Server

    Thöne, C C; Prochaska, J X; Bloom, J S; Gorosabel, J; Fynbo, J P U; Jakobsson, P; Fruchter, A S

    2014-01-01

    The spiral host galaxy of GRB 060505 at z=0.089 was the site of a puzzling long duration burst without an accompanying supernova. Studies of the burst environment by Th\\"one et al. (2008) suggested that this GRB came from the collapse of a massive star and that the GRB site was a region with properties different from the rest of the galaxy. We reobserved the galaxy in high spatial resolution using the VIMOS integral-field unit (IFU) at the VLT with a spaxel size of 0.67 arcsec. Furthermore, we use long slit high resolution data from HIRES/Keck at two different slit positions covering the GRB site, the center of the galaxy and an HII region next to the GRB region. We compare the properties of different HII regions in the galaxy with the GRB site and study the global and local kinematic properties of this galaxy. The resolved data show that the GRB site has the lowest metallicity in the galaxy with around 1/3 Z_solar, but its specific SFR (SSFR) of 7.4 M_solar/yr/L/L* and age (determined by the Halpha EW) are s...

  16. Relationships between fat deposition in the liver and skeletal muscle and insulin sensitivity in Japanese individuals: a pilot study

    Directory of Open Access Journals (Sweden)

    Eiichi Yoshimura

    2011-01-01

    < 0.01 and plasminogen activator inhibitor-1 (r = -0.58, P < 0.01 and -0.52, P < 0.05, respectively, whereas LDMA was not.Conclusion: These findings indicate that ectopic fat deposition in the liver and skeletal muscle may be associated with peripheral IS independently of body fat accumulation and aerobic capacity in middle- to older-aged Japanese individuals with visceral adiposity. Because of the small sample size, additional larger studies are needed to provide further insight into these preliminary findings.Keywords: aerobic capacity, fat in liver, lipid-rich skeletal muscle, visceral fat, subcutaneous fat, peripheral insulin sensitivity

  17. Spatial learning and psychomotor performance of C57BL/6 mice: age sensitivity and reliability of individual differences.

    Science.gov (United States)

    de Fiebre, Nancyellen C; Sumien, Nathalie; Forster, Michael J; de Fiebre, Christopher M

    2006-09-01

    Two tests often used in aging research, the elevated path test and the Morris water maze test, were examined for their application to the study of brain aging in a large sample of C57BL/6JNia mice. Specifically, these studies assessed: (1) sensitivity to age and the degree of interrelatedness among different behavioral measures derived from these tests, (2) the effect of age on variation in the measurements, and (3) the reliability of individual differences in performance on the tests. Both tests detected age-related deficits in group performance that occurred independently of each other. However, analysis of data obtained on the Morris water maze test revealed three relatively independent components of cognitive performance. Performance in initial acquisition of spatial learning in the Morris maze was not highly correlated with performance during reversal learning (when mice were required to learn a new spatial location), whereas performance in both of those phases was independent of spatial performance assessed during a single probe trial administered at the end of acquisition training. Moreover, impaired performance during initial acquisition could be detected at an earlier age than impairments in reversal learning. There were modest but significant age-related increases in the variance of both elevated path test scores and in several measures of learning in the Morris maze test. Analysis of test scores of mice across repeated testing sessions confirmed reliability of the measurements obtained for cognitive and psychomotor function. Power calculations confirmed that there are sufficiently large age-related differences in elevated path test performance, relative to within age variability, to render this test useful for studies into the ability of an intervention to prevent or reverse age-related deficits in psychomotor performance. Power calculations indicated a need for larger sample sizes for detection of intervention effects on cognitive components of the

  18. Modeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2.

    Directory of Open Access Journals (Sweden)

    Ambarish Nag

    Full Text Available The linker for activation of T cells (LAT, the linker for activation of B cells (LAB, and the linker for activation of X cells (LAX form a family of transmembrane adaptor proteins widely expressed in lymphocytes. These scaffolding proteins have multiple binding motifs that, when phosphorylated, bind the SH2 domain of the cytosolic adaptor Grb2. Thus, the valence of LAT, LAB and LAX for Grb2 is variable, depending on the strength of receptor activation that initiates phosphorylation. During signaling, the LAT population will exhibit a time-varying distribution of Grb2 valences from zero to three. In the cytosol, Grb2 forms 1:1 and 2:1 complexes with the guanine nucleotide exchange factor SOS1. The 2:1 complex can bridge two LAT molecules when each Grb2, through their SH2 domains, binds to a phosphorylated site on a separate LAT. In T cells and mast cells, after receptor engagement, receptor phosphoyrlation is rapidly followed by LAT phosphorylation and aggregation. In mast cells, aggregates containing more than one hundred LAT molecules have been detected. Previously we considered a homogeneous population of trivalent LAT molecules and showed that for a range of Grb2, SOS1 and LAT concentrations, an equilibrium theory for LAT aggregation predicts the formation of a gel-like phase comprising a very large aggregate (superaggregate. We now extend this theory to investigate the effects of a distribution of Grb2 valence in the LAT population on the formation of LAT aggregates and superaggregate and use stochastic simulations to calculate the fraction of the total LAT population in the superaggregate.

  19. Analysis of GRB 080319B and GRB 050904 within the fireshell model: evidence for a broader spectral energy distribution

    CERN Document Server

    Patricelli, Barbara; Bianco, Carlo Luciano; Caito, Letizia; de Barros, Gustavo; Izzo, Luca; Ruffini, Remo; Vereshchagin, Gregory

    2012-01-01

    (Shortened) GRB080319B, with an isotropic energy E_{iso}=1.32x10^{54}erg, and GRB050904, with E_{iso}=1.04x10^{54}erg, offer the possibility of studying the spectral properties of the prompt radiation of two of the most energetic Gamma-Ray Bursts (GRBs). This allows us to probe the validity of the fireshell model for GRBs beyond 10^{54}erg, well outside the energy range where it has been successfully tested up to now (10^{49}-10^{53}erg). We find that in the low energy region, the prompt emission spectra observed by Swift BAT reveals more power than theoretically predicted. The opportunities offered by these observations to improve the fireshell model are outlined. One of the distinguishing features of the fireshell model is that it relates the observed spectra to the spectrum in the comoving frame of the fireshell. Originally, a fully radiative condition and a comoving thermal spectrum were adopted. An additional power-law in the comoving thermal spectrum is required [...] in the fireshell model for GRBs 080...

  20. Evidence for jet launching close to the black hole in GRB 101219B - a Fermi GRB dominated by thermal emission

    CERN Document Server

    Larsson, J; Burgess, J M

    2015-01-01

    We present observations by the Fermi Gamma-Ray Space Telescope Gamma-Ray Burst Monitor (GBM) of the nearby (z=0.55) GRB 101219B. This burst is a long GRB, with an associated supernova and with a blackbody component detected in the early afterglow observed by the Swift X-ray Telescope (XRT). Here we show that the prompt gamma-ray emission has a blackbody spectrum, making this the second such burst observed by Fermi GBM. The properties of the blackbody, together with the redshift and our estimate of the radiative efficiency, makes it possible to calculate the absolute values of the properties of the outflow. We obtain an initial Lorentz factor Gamma=138\\pm 8, a photospheric radius r_phot=4.4\\pm 1.9 \\times 10^{11} cm and a launch radius r_0=2.7\\pm 1.6 \\times 10^{7} cm. The latter value is close to the event horizon for a stellar-mass black hole and suggests that the jet has a relatively unobstructed path through the star. There is no smooth connection between the blackbody components seen by GBM and XRT, ruling ...

  1. Unusual Central Engine Activity in the Double Burst GRB 110709B

    CERN Document Server

    Zhang, Bin-Bin; Zhang, Bing; Meszaros, Peter; Stratta, Giulia; D'Elia, Valerio; Frederiks, Dmitry; Golenetskii, S; Cummings, Jay R; Wang, Xiang-Yu; Falcone, Abraham D; Barthelmy, Scott D; Gehrels, Neil

    2011-01-01

    The double burst, GRB 110709B, triggered Swift/BAT twice at 21:32:39 UT and 21:43:45 UT, respectively, on 9 July 2011. This is the first time we observed a GRB with two BAT triggers. In this paper, we present simultaneous Swift and Konus-WIND observations of this unusual GRB and its afterglow. If the two events are from the same physical origin, their different time-dependent spectral evolution suggest they must belong to different episodes of the central engine, which may be a magnetar-to-BH accretion system.

  2. The GRB afterglow onset observed by REM: fireball Lorentz factor and afterglow fluence

    CERN Document Server

    Malesani, Daniele; Vergani, Susanna; Covino, Stefano

    2007-01-01

    We report observations of the early light curves of GRB 060418 and GRB 060607A, carried out with the pink robotic telescope REM. A clear peak is detected for both events, which is interpreted as the onset of the afterglow, that is the time at which the fireball starts decelerating. This detection allows to directly measure the initial fireball Lorentz factor, which was found to be Gamma_0 ~ 400 for both events, fully confirming the ultrarelativistic nature of gamma-ray burst fireballs. Sampling the light curve before the peak also allows to compute the bolometric fluence of the afterglow, which is 16% of the prompt one in the case of GRB 060418.

  3. Global Gene Expression Profiles of Subcutaneous Adipose and Muscle From Glucose-Tolerant, Insulin-Sensitive, and Insulin-Resistant Individuals Matched for BMI

    Science.gov (United States)

    Elbein, Steven C.; Kern, Philip A.; Rasouli, Neda; Yao-Borengasser, Aiwei; Sharma, Neeraj K.; Das, Swapan K.

    2011-01-01

    OBJECTIVE To determine altered gene expression profiles in subcutaneous adipose and skeletal muscle from nondiabetic, insulin-resistant individuals compared with insulin-sensitive individuals matched for BMI. RESEARCH DESIGN AND METHODS A total of 62 nondiabetic individuals were chosen for extremes of insulin sensitivity (31 insulin-resistant and 31 insulin-sensitive subjects; 40 were European American and 22 were African American) and matched for age and obesity measures. Global gene expression profiles were determined and compared between ethnic groups and between insulin-resistant and insulin-sensitive participants individually and using gene-set enrichment analysis. RESULTS African American and European American subjects differed in 58 muscle and 140 adipose genes, including many inflammatory and metabolically important genes. Peroxisome proliferator–activated receptor γ cofactor 1A (PPARGC1A) was 1.75-fold reduced with insulin resistance in muscle, and fatty acid and lipid metabolism and oxidoreductase activity also were downregulated. Unexpected categories included ubiquitination, citrullination, and protein degradation. In adipose, highly represented categories included lipid and fatty acid metabolism, insulin action, and cell-cycle regulation. Inflammatory genes were increased in European American subjects and were among the top Kyoto Encyclopedia of Genes and Genomes pathways on gene-set enrichment analysis. FADS1, VEGFA, PTPN3, KLF15, PER3, STEAP4, and AGTR1 were among genes expressed differentially in both adipose and muscle. CONCLUSIONS Adipose tissue gene expression showed more differences between insulin-resistant versus insulin-sensitive groups than the expression of genes in muscle. We confirm the role of PPARGC1A in muscle and show some support for inflammation in adipose from European American subjects but find prominent roles for lipid metabolism in insulin sensitivity independent of obesity in both tissues. PMID:21266331

  4. MIRAX sensitivity for Gamma Ray Bursts

    Science.gov (United States)

    Sacahui, J. R.; Penacchioni, A. V.; Braga, J.; Castro, M. A.; D'Amico, F.

    2016-03-01

    In this work we present the detection capability of the MIRAX (Monitor e Imageador de RAios-X) experiment for Gamma-Ray Bursts (GRBs). MIRAX is an X-ray astronomy mission designed to perform a wide band hard X-ray (10-200 keV) survey of the sky, especially in the Galactic plane. With a total detection area of 169 cm2, large field of view (FoV, 20 ° × 20 °), angular resolution of 1°45‧ and good spectral and time resolution (∼8% at 60 keV, 10 μs), MIRAX will be optimized for the detection and study of transient sources, such as accreting neutron stars (NS), black holes (BH), Active Galactic Nuclei (AGNs), and both short and long GRBs. This is especially important because MIRAX is expected to operate in an epoch when probably no other hard X-ray wide-field imager will be active. We have performed detailed simulations of MIRAX GRB observations using the GEANT4 package, including the background spectrum and images of GRB sources in order to provide accurate predictions of the sensitivity for the expected GRB rate to be observed. MIRAX will be capable of detecting ∼44 GRBs per year up to redshifts of ∼4.5. The MIRAX mission will be able to contribute significantly to GRB science by detecting a large number of GRBs per year with wide band spectral response. The observations will contribute mainly to the part of GRB spectra where a thermal emission is predicted by the Fireball model. We also discuss the possibility of detecting GRB afterglows in the X-ray band with MIRAX.

  5. Making a Short Gamma-Ray Burst from a Long one: Implications for the Nature of GRB 060614

    CERN Document Server

    Zhang, B; Liang, E W; Gehrels, N; Burrows, D N; Mészáros, P; Zhang, Bing; Zhang, Bin-Bin; Liang, En-Wei; Gehrels, Neil; Burrows, David N.; Meszaros, Peter

    2006-01-01

    The absence of a supernova accompanying the nearby long GRB 060614 poses a great puzzle about the progenitor of this event and challenges the current GRB classification scheme. This burst displays a short-hard emission episode followed by extended soft emission with strong spectral evolution. Noticing that this burst has an isotropic gamma-ray energy only ~8 times that of GRB 050724, a good candidate of merger-type short GRBs, we generate a ``pseudo'' burst that is ~8 times less energetic than GRB 060614 based on the spectral properties of GRB 060614 and the Ep ~ Eiso^{1/2} (Amati) relation. We find that this pseudo-burst would have been detected by BATSE as a marginal short-duration GRB, and would have properties in the Swift BAT and XRT bands similar to GRB 050724. This suggests that GRB 060614 is likely a more intense event in the traditional short-hard GRB category as would be detected by BATSE. Events like GRB 060614 that seem to defy the traditional short vs. long classification of GRBs may require modi...

  6. A nearby GRB host prototype for z~7 Lyman-break galaxies: Spitzer-IRS and X-shooter spectroscopy of the host galaxy of GRB031203

    CERN Document Server

    Watson, D; Christensen, L; O'Halloran, B; Michałowski, M; Hjorth, J; Malesani, D; Fynbo, J P U; Gordon, K D; Cerón, J M Castro

    2010-01-01

    Gamma-ray burst (GRB) host galaxies have been studied extensively in optical photometry and spectroscopy. Here we present the first mid-infrared spectrum of a GRB host, HG031203. It is one of the nearest GRB hosts at z=0.1055, allowing both low and high-resolution spectroscopy with Spitzer-IRS. Medium resolution UV-to-K-band spectroscopy with the X-shooter spectrograph on the VLT is also presented, along with Spitzer IRAC and MIPS photometry, as well as radio and sub-mm observations. These data allow us to construct a UV-to-radio spectral energy distribution with almost complete spectroscopic coverage from 0.3-35 micron of a GRB host galaxy for the first time, potentially valuable as a template for future model comparisons. The IRS spectra show strong, high-ionisation fine structure line emission indicative of a hard radiation field in the galaxy, suggestive of strong ongoing star-formation and a very young stellar population. The selection of HG031203 via the presence of a GRB suggests that it might be a use...

  7. GRB hosts through cosmic time - VLT/X-shooter emission-line spectroscopy of 96 GRB-selected galaxies at 0.1 < z < 3.6

    CERN Document Server

    Krühler, T; Fynbo, J P U; Hartoog, O E; Hjorth, J; Jakobsson, P; Perley, D A; Rossi, A; Schady, P; Schulze, S; Tanvir, N R; Vergani, S D; Wiersema, K; Afonso, P M J; Bolmer, J; Cano, Z; Covino, S; D'Elia, V; Postigo, A de Ugarte; Filgas, R; Friis, M; Graham, J F; Greiner, J; Goldoni, P; Gomboc, A; Hammer, F; Japelj, J; Kann, D A; Kaper, L; Klose, S; Levan, A J; Leloudas, G; Milvang-Jensen, B; Guelbenzu, A Nicuesa; Palazzi, E; Pian, E; Piranomonte, S; Sanchez-Ramirez, R; Savaglio, S; Selsing, J; Tagliaferri, G; Vreeswijk, P M; Watson, D J; Xu, D

    2015-01-01

    We present data and initial results from VLT/X-shooter emission-line spectroscopy of 96 GRB-selected galaxies at 0.1GRB host spectroscopy available to date. The majority of our GRBs was detected by Swift and 76% are at 0.5GRB hosts with redshift. The median SFR, for example, increases from ~0.6 M_sun/yr at z~0.6 up to ~15 M_sun/yr at z~2. A higher ratio of [OIII]/[OII] at higher redshifts leads to an increasing distance of GRB-selected galaxies to the locus of local galaxies in the BPT diagram. Oxygen abundances of the galaxies are distributed between 12+log(O/H)=7.9 and 12+log(O/H)=9.0 with a median of 12+log(O/H)~8.5. The fraction of GRB-selected galaxies with super-solar metallic...

  8. Individual differences in ethanol locomotor sensitization are associated with dopamine D1 receptor intra-cellular signaling of DARPP-32 in the nucleus accumbens.

    Directory of Open Access Journals (Sweden)

    Karina Possa Abrahao

    Full Text Available In mice there are clear individual differences in the development of behavioral sensitization to ethanol, a progressive potentiation of its psychomotor stimulant effect. Variability in the behavioral responses to ethanol has been associated with alcohol preference. Here we investigated if the functional hyperresponsiveness of D1 receptors observed in ethanol sensitized mice leads to an increased activation of DARPP-32, a central regulatory protein in medium spiny neurons, in the nucleus accumbens - a brain region known to play a role in drug reinforcement. Swiss Webster mice received ethanol (2.2 g/kg/day or saline i.p. administrations for 21 days and were weekly evaluated regarding their locomotor activity. From those treated with ethanol, the 33% with the highest levels of locomotor activity were classified as "sensitized" and the 33% with the lowest levels as "non-sensitized". The latter presented similar locomotor levels to those of saline-treated mice. Different subgroups of mice received intra-accumbens administrations of saline and, 48 h later, SKF-38393, D1 receptor agonist 0.1 or 1 µg/side. Indeed, sensitized mice presented functional hyperresponsiveness of D1 receptors in the accumbens. Two weeks following the ethanol treatment, other subgroups received systemic saline or SKF 10 mg/kg, 20 min before the euthanasia. The nucleus accumbens were dissected for the Western Blot analyses of total DARPP-32 and phospho-Thr34-DARPP-32 expression. D1 receptor activation induced higher phospho-Thr34-DARPP-32 expression in sensitized mice than in non-sensitized or saline. The functionally hyperresponsiveness of D1 receptors in the nucleus accumbens is associated with an increased phospho-Thr34-DARPP-32 expression after D1 receptor activation. These data suggest that an enduring increase in the sensitivity of the dopamine D1 receptor intracellular pathway sensitivity represents a neurobiological correlate associated with the development of

  9. GRB optical and IR rapid follow-up with the 2 m Liverpool Robotic Telescope

    CERN Document Server

    Gomboc, A; Carter, D; Mundell, C G; Newsam, A M; Smith, R J; Steele, I A

    2003-01-01

    The Liverpool Telescope, owned and operated by Liverpool John Moores University and situated at Roque de los Muchachos, La Palma, is the first 2-m, fully instrumented robotic telescope. We plan to use the LT in conjunction with Gamma Ray Observatories (HETE-2, INTEGRAL, Swift) to study GRB physics. A special over-ride mode will enable observations commencing less than a minute after the GRB alert, including optical and near infrared imaging and spectroscopy. These observations, together with systematic monitoring of the burst through the afterglow, will help to unravel the nature of prompt optical flashes, short bursts, optically dark bursts, redshift distribution, GRB - supernova connection and other questions related to the GRB phenomenon. In particular, the combination of aperture, instrumentation and rapid automated response makes the Liverpool Telescope excellently suited to the investigation of optically dark bursts and currently optically unstudied short bursts.

  10. A Missing-Link in the Supernova-GRB Connection: The Case of SN 2012ap

    CERN Document Server

    Chakraborti, Sayan; Chomiuk, Laura; Kamble, Atish; Yadav, Naveen; Ray, Alak; Hurley, Kevin; Margutti, Raffaella; Milisavljevic, Dan; Bietenholz, Michael; Brunthaler, Andreas; Pignata, Giuliano; Pian, Elena; Mazzali, Paolo; Fransson, Claes; Bartel, Norbert; Hamuy, Mario; Levesque, Emily; MacFadyen, Andrew; Dittmann, Jason; Krauss, Miriam; Briggs, M S; Connaughton, V; Yamaoka, K; Takahashi, T; Ohno, M; Fukazawa, Y; Tashiro, M; Terada, Y; Murakami, T; Goldsten, J; Barthelmy, S; Gehrels, N; Cummings, J; Krimm, H; Palmer, D; Golenetskii, S; Aptekar, R; Frederiks, D; Svinkin, D; Cline, T; Mitrofanov, I G; Golovin, D; Litvak, M L; Sanin, A B; Boynton, W; Fellows, C; Harshman, K; Enos, H; von Kienlin, A; Rau, A; Zhang, X; Savchenko, V

    2014-01-01

    Gamma Ray Bursts (GRBs) are characterized by ultra-relativistic outflows, while supernovae are generally characterized by non-relativistic ejecta. GRB afterglows decelerate rapidly usually within days, because their low-mass ejecta rapidly sweep up a comparatively larger mass of circumstellar material. However supernovae, with heavy ejecta, can be in nearly free expansion for centuries. Supernovae were thought to have non-relativistic outflows except for few relativistic ones accompanied by GRBs. This clear division was blurred by SN 2009bb, the first supernova with a relativistic outflow without an observed GRB. Yet the ejecta from SN 2009bb was baryon loaded, and in nearly-free expansion for a year, unlike GRBs. We report the first supernova discovered without a GRB, but with rapidly decelerating mildly relativistic ejecta, SN 2012ap. This shows that central engines in type Ic supernovae, even without an observed GRB, can produce both relativistic and rapidly decelerating outflows like GRBs.

  11. Clustering of galaxies around the GRB 021004 sight-line at z ~ 0.5

    Science.gov (United States)

    Sokolov, Ilya V.; Castro-Tirado, A. J.; Verkhodanov, O. V.; Zhelenkova, O. P.; Baryshev, Yu. V.

    2016-06-01

    In this report we test for reliability any signatures of field galaxies clustering in the GRB 021004 line of sight. The first signature is the BTA and Hubble GRB 021004 field photometric redshift distribution with a peak at z ~ 0.5 estimated from multicolor photometry. The second signature is the MgII 2796,2803 absorption doublet at z ~ 0.5 in the GRB 021004 afterglow spectrum. The third signature is some inhomogeneity in Plank + GRB 021004 fields. And the fourth signature may be the galaxy clustering with an effective redshift of z = 0.5 from the Baryon Oscillation Spectroscopic Survey (BOSS), which is a part of the Sloan Digital Sky Survey III (SDSS-III).

  12. Afterglow from GRB 070610/Swift J195509.6+261406:An explanation using the fireball model

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    GRB 070610,which is also named Swift J195509.6+261406,is a peculiar Galactic transient with significant variability on short timescales in both X-ray and optical light curves.One possible explanation is that GRB 070610/Swift J195509.6 + 261406 is a soft gamma-ray repeater(SGR) in our Galaxy.Here,we use the fireball model,which is usually recognized as the standard model of gamma-ray burst(GRB) afterglows,and the energy injection hypothesis to interpret the X-ray and optical afterglow light curves of GRB 070610/Swift J195509.6 + 261406.It is found that the model is generally consistent with observations.

  13. Constraints on an Optical Afterglow and on Supernova Light Following the Short Burst GRB 050813

    Science.gov (United States)

    Ferrero, P.; Sanchez, S. F.; Kann, D. A.; Klose, S.; Greiner, J.; Gorosabel, J.; Hartmann, D. H.; Henden, A. A.; Moller, P.; Palazzi, E.; Rau, A.; Stecklum, B.; Castro-Tirado, A. J.; Fynbok J. P. U.; Hjorth, J.; Jakobsson, P.; Kouveliotou, C.; Masetti, N.; Pian, E.; Tanvir, N. R.; Wijers, R. A. M. J.

    2006-01-01

    We report early follow-up observations of the error box of the short burst 050813 using the telescopes at Calar Alto and at Observatorio Sierra Nevada (OSN), followed by deep VLT/FORS2 I-band observations obtained under very good seeing conditions 5.7 and 11.7 days after the event. No evidence for a GRB afterglow was found in our Calar Alto and OSN data, no rising supernova component was detected in our FORS2 images. A potential host galaxy can be identified in our FORS2 images, even though we cannot state with certainty its association with GRB 050813. IN any case, the optical afterglow of GRB 050813 was very faint, well in agreement with what is known so far about the optical properties of afterglows of short bursts. We conclude that all optical data are not in conflict with the interpretation that GRB 050813 was a short burst.

  14. GRB 990123 Reverse and Internal Shock Flashes and Late Afterglow

    CERN Document Server

    Mészáros, P

    1999-01-01

    The prompt $(t \\siml 0.16$ days) light curve and initial 9-th magnitude optical flash from GRB 990123 can be attributed to a reverse external shock, or possibly to internal shocks. We discuss the time decay laws and spectral slopes expected under various dynamical regimes, and discuss the constraints imposed on the model by the observations, arguing that they provide strongly suggestive evidence for features beyond those in the simple standard model. The longer term afterglow behavior is discussed in the context of the forward shock, and it is argued that, if the steepening after three days is due to a jet geometry, this is likely to be due to jet-edge effects, rather than sideways expansion.

  15. A template for describing intrinsic GRB pulse shapes

    CERN Document Server

    Hakkila, Jon; Wolpert, Robert L; Broadbent, Mary E; Preece, Robert D

    2013-01-01

    A preliminary study of a set of well-isolated pulses in GRB light curves indicates that simple pulse models, with smooth and monotonic pulse rise and decay regions, are inadequate. Examining the residuals of fits of pulses to such models suggests the following patterns of departure from the smooth pulse model of Norris et al. (2005): A Precursor Shelf occurs prior to or concurrent with the exponential Rapid Rise. The pulse reaches maximum intensity at the Peak Plateau, then undergoes a Rapid Decay. The decay changes into an Extended Tail. Pulses are almost universally characterized by hard-to-soft evolution, arguing that the new pulse features reflect a single physical phenomenon, rather than artifacts of pulse overlap.

  16. GRB-081029: A Step Towards Understanding Multiple Afterglow Components

    Science.gov (United States)

    Holland Stephen T.

    2010-01-01

    We present an analysis of the unusual optical light curve of the gamma-ray burst-081029 at a redshift of z = 3.8474. We combine X-ray and optical observations from (Swift) with optical and infrared data from REM to obtain a detailed data set extending from approx 10(exp 2)s to approx 10(exp 5)s after the BAT trigger, and from approx.10 keV to 16,000 AA. The X-ray afterglow showed a shallow initial decay followed by u rapid decay after about 18,000 s. The optical afterglow, however, shows an uncharecteristic rise at about 5000 s that has no corresponding feature in the X-ray light curve. The data are not consistent with a single-component jet. It is possible that there are multiple physical components contributing to the afterglow of GRB-081029.

  17. The optical afterglow and host galaxy of GRB 000926

    DEFF Research Database (Denmark)

    Fynbo, J.U.; Gorosabel, J.; Dall, T.H.;

    2002-01-01

    In this paper we illustrate with the case of GRB 000926 how Gamma Ray Bursts (GRBs) can be used as cosmological lighthouses to identify and study star forming galaxies at high redshifts. The optical afterglow of the burst was located with optical imaging at the Nordic Optical Telescope 20.7 hours...... after the burst. Rapid follow-up spectroscopy allowed the determination of the redshift of the burst and a measurement of the host galaxy HI-column density in front of the burst. With late-time narrow band Lyalpha as well as broad band imaging, we have studied the emission from the host galaxy and found...... that it is a strong Lyalpha emitter in a state of active star formation....

  18. Jet or shock breakout? The low-luminosity GRB 060218

    Science.gov (United States)

    Irwin, Christopher M.; Chevalier, Roger A.

    2016-08-01

    We consider a model for the low-luminosity gamma-ray burst GRB 060218 that plausibly accounts for multiwavelength observations to day 20. The model components are: (1) a long-lived (tj ˜ 3000 s) central engine and accompanying low-luminosity (Lj ˜ 1047 erg s-1), mildly relativistic (γ ˜ 10) jet; (2) a low-mass (˜4 × 10-3 M⊙) envelope surrounding the progenitor star; and (3) a modest amount of dust (AV ˜ 0.1 mag) in the circumstellar or interstellar environment. Blackbody emission from the transparency radius in a low-power jet outflow can fit the prompt thermal X-ray emission, and the non-thermal X-rays and gamma-rays may be produced via Compton scattering of thermal photons from hot leptons in the jet interior or the external shocks. The later mildly relativistic phase of this outflow can produce the radio emission via synchrotron radiation from the forward shock. Meanwhile, interaction of the associated SN 2006aj with a circumstellar envelope extending to ˜1013 cm can explain the early optical emission. The X-ray afterglow can be interpreted as a light echo of the prompt emission from dust at ˜30 pc. Our model is a plausible alternative to that of Nakar, who recently proposed shock breakout of a jet smothered by an extended envelope as the source of prompt emission. Both our results and Nakar's suggest that bursts such as GRB 060218 may originate from unusual progenitors with extended circumstellar envelopes, and that a jet is necessary to decouple the prompt emission from the supernova.

  19. Probing the bright radio flare and afterglow of GRB 130427A with the Arcminute Microkelvin Imager

    NARCIS (Netherlands)

    Anderson, G.E.; van der Horst, A.J.; Staley, T.D.; Fender, R.P.; Wijers, R.A.M.J.; Scaife, A.M.M.; Rumsey, C.; Titterington, D.J.; Rowlinson, A.; Saunders, R.D.E.

    2014-01-01

    We present one of the best sampled early-time light curves of a gamma-ray burst (GRB) at radio wavelengths. Using the Arcminute Mircrokelvin Imager (AMI), we observed GRB 130427A at the central frequency of 15.7 GHz between 0.36 and 59.32 d post-burst. These results yield one of the earliest radio d

  20. Observations of the Prompt Optical Emission of GRB 160625B with Mini-MegaTORTORA

    Science.gov (United States)

    Karpov, S.; Beskin, G.; Biryukov, A.; Bondar, S.; Ivanov, E.; Katkova, E.; Orekhova, N.; Perkov, A.; Sasyuk, V.

    2017-06-01

    Here we report our observations of bright optical flash coincident with Fermi GRB160625B using Mini-MegaTORTORA wide-field monitoring system. The prompt optical emission is correlated with gamma one and lags behind it for about 3 seconds, that suggests that optical and gamma emission are formed in different regions of the burst. The multiwavelength properties of this burst are very similar to ones of Naked-Eye Burst, GRB080319B, we detected earlier with TORTORA camera.

  1. A Decade of GRB Follow-Up by BOOTES in Spain (2003–2013

    Directory of Open Access Journals (Sweden)

    Martin Jelínek

    2016-01-01

    Full Text Available This article covers ten years of GRB follow-ups by the Spanish BOOTES stations: 71 follow-ups providing 23 detections. Follow-ups by BOOTES-1B from 2005 to 2008 were given in a previous article and are here reviewed and updated, and additional detection data points are included as the former article merely stated their existence. The all-sky cameras CASSANDRA have not yet detected any GRB optical afterglows, but limits are reported where available.

  2. Multi-wavelength afterglow observations of the high redshift GRB 050730

    OpenAIRE

    2006-01-01

    GRB 050730 is a long duration high-redshift burst (z=3.967) discovered by Swift. The afterglow shows variability and is well monitored over a wide wavelength range. We present comprehensive temporal and spectral analysis of the afterglow of GRB 050730 including observations from the millimeter to X-rays. We use multi-wavelength afterglow data to understand the temporal and spectral decay properties with superimposed variability of this high redshift burst. Five telescopes were used to study t...

  3. Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice.

    Directory of Open Access Journals (Sweden)

    Rana Mroue

    2015-05-01

    Full Text Available Imprinted genes are expressed from only one parental allele and heterozygous loss involving the expressed allele is sufficient to produce complete loss of protein expression. Genetic alterations are common in tumorigenesis but the role of imprinted genes in this process is not well understood. In earlier work we mutagenized mice heterozygous for the Neurofibromatosis I tumor suppressor gene (NF1 to model radiotherapy-associated second malignant neoplasms that arise in irradiated NF1 patients. Expression analysis of tumor cell lines established from our mouse models identified Grb10 expression as widely absent. Grb10 is an imprinted gene and polymorphism analysis of cell lines and primary tumors demonstrates that the expressed allele is commonly lost in diverse Nf1 mutant tumors arising in our mouse models. We performed functional studies to test whether Grb10 restoration or loss alter fundamental features of the tumor growth. Restoring Grb10 in Nf1 mutant tumors decreases proliferation, decreases soft agar colony formation and downregulates Ras signaling. Conversely, Grb10 silencing in untransformed mouse embryo fibroblasts significantly increased cell proliferation and increased Ras-GTP levels. Expression of a constitutively activated MEK rescued tumor cells from Grb10-mediated reduction in colony formation. These studies reveal that Grb10 loss can occur during in vivo tumorigenesis, with a functional consequence in untransformed primary cells. In tumors, Grb10 loss independently promotes Ras pathway hyperactivation, which promotes hyperproliferation, an early feature of tumor development. In the context of a robust Nf1 mutant mouse model of cancer this work identifies a novel role for an imprinted gene in tumorigenesis.

  4. Structural basis for the interaction of the adaptor protein grb14 with activated ras.

    Directory of Open Access Journals (Sweden)

    Rohini Qamra

    Full Text Available Grb14, a member of the Grb7-10-14 family of cytoplasmic adaptor proteins, is a tissue-specific negative regulator of insulin signaling. Grb7-10-14 contain several signaling modules, including a Ras-associating (RA domain, a pleckstrin-homology (PH domain, a family-specific BPS (between PH and SH2 region, and a C-terminal Src-homology-2 (SH2 domain. We showed previously that the RA and PH domains, along with the BPS region and SH2 domain, are necessary for downregulation of insulin signaling. Here, we report the crystal structure at 2.4-Å resolution of the Grb14 RA and PH domains in complex with GTP-loaded H-Ras (G12V. The structure reveals that the Grb14 RA and PH domains form an integrated structural unit capable of binding simultaneously to small GTPases and phosphoinositide lipids. The overall mode of binding of the Grb14 RA domain to activated H-Ras is similar to that of the RA domains of RalGDS and Raf1 but with important distinctions. The integrated RA-PH structural unit in Grb7-10-14 is also found in a second adaptor family that includes Rap1-interacting adaptor molecule (RIAM and lamellipodin, proteins involved in actin-cytoskeleton rearrangement. The structure of Grb14 RA-PH in complex with H-Ras represents the first detailed molecular characterization of tandem RA-PH domains bound to a small GTPase and provides insights into the molecular basis for specificity.

  5. A decade of GRB follow-up by BOOTES in Spain (2003-2013)

    CERN Document Server

    Jelínek, Martin; Cunniffe, Ronan; Gorosabel, Javier; Vítek, Stanislav; Kubánek, Petr; Postigo, Antonio de Ugarte; Guziy, Sergey; Tello, Juan C; Páta, Petr; Sánchez-Ramírez, Rubén; Oates, Samantha; Jeong, Soomin; Štrobl, Jan; Castillo-Carrión, Sebastián; Sanguino, Tomás Mateo; Rabaza, Ovidio; Pérez-Ramírez, Dolores; Fernández-Muñoz, Rafael; Carretero, Benito A de la Morena; Hudec, René; Reglero, Víctor; Sabau-Graziati, Lola

    2016-01-01

    This article covers ten years of GRB follow-ups by the Spanish BOOTES stations: 71 follow-ups providing 23 detections. Follow-ups by BOOTES-1B from 2005 to 2008 were given in the previous article, and are here reviewed, updated, and include additional detection data points as the former article merely stated their existence. The all-sky cameras CASSANDRA have not yet detected any GRB optical afterglows, but limits are reported where available.

  6. Variation in drug sensitivity of malignant mesothelioma cell lines with substantial effects of selenite and bortezomib, highlights need for individualized therapy.

    Directory of Open Access Journals (Sweden)

    Adam Szulkin

    Full Text Available BACKGROUND: Malignant mesothelioma cells have an epithelioid or sarcomatoid morphology, both of which may be present in the same tumor. The sarcomatoid phenotype is associated with worse prognosis and heterogeneity of mesothelioma cells may contribute to therapy resistance, which is often seen in mesothelioma. This study aimed to investigate differences in sensitivity between mesothelioma cell lines to anti-cancer drugs. We studied two novel drugs, selenite and bortezomib and compared their effect to four conventional drugs. We also investigated the immunoreactivity of potential predictive markers for drug sensitivity; Pgp, MRP-1, ERCC1, RRM1, TS, xCT and proteasome 20S subunit. MATERIALS AND METHODS: We treated six mesothelioma cell lines with selenite, bortezomib, carboplatin, pemetrexed, doxorubicin or gemcitabine as single agents and in combinations. Viability was measured after 24 and 48 hours. Immunocytochemistry was used to detect predictive markers. RESULTS: As a single agent, selenite was effective on four out of six cell lines, and in combination with bortezomib yielded the greatest response in the studied mesothelioma cell lines. Cells with an epithelioid phenotype were generally more sensitive to the different drugs than the sarcomatoid cells. Extensive S-phase arrest was seen in pemetrexed-sensitive cell lines. MRP-1 predicted sensitivity of cell lines to treatment with carboplatin and xCT predicted pemetrexed effect. CONCLUSIONS: The observed heterogeneity in sensitivity of mesothelioma cell lines with different morphology highlights the need for more individualized therapy, requiring development of methods to predict drug sensitivity of individual tumors. Selenite and bortezomib showed a superior effect compared to conventional drugs, motivating clinical testing of these agents as future treatment regime components for patients with malignant mesothelioma.

  7. Is individual nasal sensitivity related to cellular metabolism of formaldehyde and susceptibility towards formaldehyde-induced genotoxicity?

    Science.gov (United States)

    Zeller, Jasmin; Ulrich, Alexandra; Mueller, Joerg U; Riegert, Clarissa; Neuss, Simone; Bruckner, Thomas; Triebig, Gerhard; Speit, Günter

    2011-07-14

    Forty-one volunteers (male non-smokers, aged 32 ± 9.6yrs) were tested for susceptibility towards unspecific nasal irritation (sensitivity towards CO(2)) in order to define subgroups of hypersensitive and hyposensitive subjects. Blood samples were taken and the expression (mRNA level) of the GSH-dependent formaldehyde dehydrogenase gene (FDH, identical to alcohol dehydrogenase 5, ADH5; EC 1.2.1.46) was measured in leukocytes by quantitative real-time RT-PCR with TaqMan probes. FDH is the most important enzyme for the metabolic inactivation of FA. Blood samples were exposed to 150μM formaldehyde (FA) for 2h and the induction of DNA-protein crosslinks (DPX) in leukocytes was measured by means of a modification of the alkaline comet assay (i.e., by assessing the reduction of DNA migration induced by γ-radiation). Removal of DPX was determined by the abolition of FA-induced reduction in DNA migration within 4h after the end of the exposure. Furthermore, the induction of sister chromatid exchange (SCE) in cultured lymphocytes was studied after treatment of whole blood cultures with FA (150μM). A correlation analysis was performed for all parameters tested for the whole study group and for hypersensitive and hyposensitive subgroups. The results indicate that despite large differences in CO(2)-sensitivity, the susceptibility towards nasal irritation was not related to the induction of genotoxic effects (DPX, SCE) in peripheral blood or to the protection of blood cells against FA-induced effects (expression of FDH, repair capacity for FA-induced DPX). There was no correlation between CO(2)-sensitivity and the expression of FDH. There was also no close correlation between the various indicators of cellular sensitivity towards FA-induced genotoxic effects and no subgroups were identified with particular mutagen sensitivity towards FA.

  8. Fusion protein based on Grb2-SH2 domain for cancer therapy

    Energy Technology Data Exchange (ETDEWEB)

    Saito, Yuriko [Molecular Imaging Center, National Institute of Radiological Sciences (Japan); Graduate School of Pharmaceutical Sciences, Chiba University (Japan); Furukawa, Takako, E-mail: tfuru@nirs.go.jp [Molecular Imaging Center, National Institute of Radiological Sciences (Japan); Biomedical Imaging Research Center, University of Fukui (Japan); Arano, Yasushi [Graduate School of Pharmaceutical Sciences, Chiba University (Japan); Fujibayashi, Yasuhisa [Molecular Imaging Center, National Institute of Radiological Sciences (Japan); Biomedical Imaging Research Center, University of Fukui (Japan); Saga, Tsuneo [Molecular Imaging Center, National Institute of Radiological Sciences (Japan)

    2010-08-20

    Research highlights: {yields} Grb2 mediates EGFR signaling through binding to phosphorylate EGFR with SH2 domain. {yields} We generated fusion proteins containing 1 or 2 SH2 domains of Grb2 added with TAT. {yields} The one with 2 SH2 domains (TSSF) interfered ERK phosphorylation. {yields} TSSF significantly delayed the growth of EGFR overexpressing tumor in a mouse model. -- Abstract: Epidermal growth factor receptor (EGFR) is one of the very attractive targets for cancer therapy. In this study, we generated fusion proteins containing one or two Src-homology 2 (SH2) domains of growth factor receptor bound protein 2 (Grb2), which bind to phosphorylated EGFR, added with HIV-1 transactivating transcription for cell membrane penetration (termed TSF and TSSF, respectively). We examined if they can interfere Grb2-mediated signaling pathway and suppress tumor growth as expected from the lack of SH3 domain, which is necessary to intermediate EGFR-Grb2 cell signaling, in the fusion proteins. The transduction efficiency of TSSF was similar to that of TSF, but the binding activity of TSSF to EGFR was higher than that of TSF. Treatment of EGFR-overexpressing cells showed that TSSF decreased p42-ERK phosphorylation, while TSF did not. Both the proteins delayed cell growth but did not induce cell death in culture. TSSF also significantly suppressed tumor growth in vivo under consecutive administration. In conclusion, TSSF showed an ability to inhibit EGFR-Grb2 signaling and could have a potential to treat EGFR-activated cancer.

  9. A MISSING-LINK IN THE SUPERNOVA–GRB CONNECTION: THE CASE OF SN 2012ap

    Energy Technology Data Exchange (ETDEWEB)

    Chakraborti, Sayan; Soderberg, Alicia; Kamble, Atish; Margutti, Raffaella; Milisavljevic, Dan; Dittmann, Jason [Institute for Theory and Computation, Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Chomiuk, Laura [Department of Physics and Astronomy, Michigan State University, East Lansing, MI 48824 (United States); Yadav, Naveen; Ray, Alak [Tata Institute of Fundamental Research, 1 Homi Bhabha Road, Mumbai 400005 (India); Hurley, Kevin [Space Sciences Laboratory, University of California, 7 Gauss Way, Berkeley, CA 94720 (United States); Bietenholz, Michael [Department of Physics and Astronomy, York University, 4700 Keele St., M3J 1P3 Ontario (Canada); Brunthaler, Andreas [Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Pignata, Giuliano [Departamento de Ciencias Fisicas, Universidad Andres Bello, Avda. Republica 252, Santiago (Chile); Pian, Elena [Scuola Normale Superiore, Piazza Dei Cavalieri 7—I-56126 Pisa (Italy); Mazzali, Paolo [Liverpool John Moores University, IC2, 146 Brownlow Hill, Liverpool (United Kingdom); Fransson, Claes [Department of Astronomy, Stockholm University, AlbaNova, SE-106 91 Stockholm (Sweden); Bartel, Norbert [Hartebeesthoek Radio Astronomy Observatory, PO Box 443, Krugersdrop, 1740 (South Africa); Hamuy, Mario [Departamento de Astronoma, Universidad de Chile (Chile); Levesque, Emily [University of Colorado, C327A, Boulder, CO 80309 (United States); MacFadyen, Andrew, E-mail: schakraborti@fas.harvard.edu [New York University, 4 Washington Place, New York, NY 10003 (United States); and others

    2015-06-01

    Gamma-ray bursts (GRBs) are characterized by ultra-relativistic outflows, while supernovae are generally characterized by non-relativistic ejecta. GRB afterglows decelerate rapidly, usually within days, because their low-mass ejecta rapidly sweep up a comparatively larger mass of circumstellar material. However, supernovae with heavy ejecta can be in nearly free expansion for centuries. Supernovae were thought to have non-relativistic outflows except for a few relativistic ones accompanied by GRBs. This clear division was blurred by SN 2009bb, the first supernova with a relativistic outflow without an observed GRB. However, the ejecta from SN 2009bb was baryon loaded and in nearly free expansion for a year, unlike GRBs. We report the first supernova discovered without a GRB but with rapidly decelerating mildly relativistic ejecta, SN 2012ap. We discovered a bright and rapidly evolving radio counterpart driven by the circumstellar interaction of the relativistic ejecta. However, we did not find any coincident GRB with an isotropic fluence of more than one-sixth of the fluence from GRB 980425. This shows for the first time that central engines in SNe Ic, even without an observed GRB, can produce both relativistic and rapidly decelerating outflows like GRBs.

  10. Probing the Nature of Short Swift Bursts via Deep INTEGRAL Monitoring of GRB 050925

    Science.gov (United States)

    Sakamoto, T.; Barbier, L.; Barthelmy, S. D.; Cummings, J. R.; Fenimore, E. E.; Gehrels, N.; Krimm, H. A.; Markwardt, C. B.; Palmer, D. M.; Parsons, A. M.; hide

    2010-01-01

    We present results from Swift, XMM-Newton, and deep INTEGRAL monitoring in the region of GRB 050925. This short Swift burst is a candidate for a newly discovered soft gamma-ray repeater (SGR) with the following observational burst properties: 1) galactic plane (b=-0.1 deg) localization, 2) 150 msec duration, and 3) a blackbody rather than a simple power-law spectral shape (with a significance level of 97%). We found two possible X-ray counterparts of GRB 050925 by comparing the X-ray images from Swift XRT and XMM-Newton. Both X-ray sources show the transient behavior with a power-law decay index shallower than -1. We found no hard X-ray emission nor any additional burst from the location of GRB 050925 in approximately 5 Ms of INTEGRAL data. We discuss about the three BATSE short bursts which might be associated with GRB 050925, based on their location and the duration. Assuming GRB 050925 is associated with the H(sub II), regions (W 58) at the galactic longitude of 1=70 deg, we also discuss the source frame properties of GRB 050925.

  11. Grb10 characterization in bovine cumulus oocyte complexes from different follicle sizes

    Directory of Open Access Journals (Sweden)

    Paulo Roberto Antunes da Rosa

    2015-05-01

    Full Text Available The objective of this study was to investigate the mRNA expression and protein localization of Grb10 gene in bovine cumulus-oocyte complexes (COCs from different follicle sizes. Firstly, it was investigated the mRNA expression to correlate with maturation rates. COCs from follicles at 1-3, 4-6, 6-8 and >8mm were used to evaluate Grb10 gene expression by qRT-PCR assay and nuclear maturation rates. It was observed that more competent oocytes (from follicles at 6-8 and >8mm; P>0.05, had lower Grb10 mRNA expression levels when compared to the oocytes from follicles at 1-3 and 4-6mm (P>0.05. After it was performed an immunofluorescence analysis in COCs from different follicle sizes (1-3, 4-6, 6-8 and >8mm to investigate Grb10 protein localization. Samples were incubated with primary antibody: Polyclonal rabbit anti-Grb10 (1:100. Primary antibody was detected using goat anti-rabbit IgG antibody conjugated with Alexa Fluor 488 (1:500. Positive fluorescence signal was detected in all analyzed samples but less evident in COCs from largest follicles. These results characterized Grb10 gene in bovine COC and provide evidences for its involvement during oocyte molecular maturation.

  12. Routine OGTT: a robust model including incretin effect for precise identification of insulin sensitivity and secretion in a single individual.

    Science.gov (United States)

    De Gaetano, Andrea; Panunzi, Simona; Matone, Alice; Samson, Adeline; Vrbikova, Jana; Bendlova, Bela; Pacini, Giovanni

    2013-01-01

    In order to provide a method for precise identification of insulin sensitivity from clinical Oral Glucose Tolerance Test (OGTT) observations, a relatively simple mathematical model (Simple Interdependent glucose/insulin MOdel SIMO) for the OGTT, which coherently incorporates commonly accepted physiological assumptions (incretin effect and saturating glucose-driven insulin secretion) has been developed. OGTT data from 78 patients in five different glucose tolerance groups were analyzed: normal glucose tolerance (NGT), impaired glucose tolerance (IGT), impaired fasting glucose (IFG), IFG+IGT, and Type 2 Diabetes Mellitus (T2DM). A comparison with the 2011 Salinari (COntinuos GI tract MOdel, COMO) and the 2002 Dalla Man (Dalla Man MOdel, DMMO) models was made with particular attention to insulin sensitivity indices ISCOMO, ISDMMO and kxgi (the insulin sensitivity index for SIMO). ANOVA on kxgi values across groups resulted significant overall (P<0.001), and post-hoc comparisons highlighted the presence of three different groups: NGT (8.62×10(-5)±9.36×10(-5) min(-1)pM(-1)), IFG (5.30×10(-5)±5.18×10(-5)) and combined IGT, IFG+IGT and T2DM (2.09×10(-5)±1.95×10(-5), 2.38×10(-5)±2.28×10(-5) and 2.38×10(-5)±2.09×10(-5) respectively). No significance was obtained when comparing ISCOMO or ISDMMO across groups. Moreover, kxgi presented the lowest sample average coefficient of variation over the five groups (25.43%), with average CVs for ISCOMO and ISDMMO of 70.32% and 57.75% respectively; kxgi also presented the strongest correlations with all considered empirical measures of insulin sensitivity. While COMO and DMMO appear over-parameterized for fitting single-subject clinical OGTT data, SIMO provides a robust, precise, physiologically plausible estimate of insulin sensitivity, with which habitual empirical insulin sensitivity indices correlate well. The kxgi index, reflecting insulin secretion dependency on glycemia, also significantly differentiates clinically

  13. Routine OGTT: a robust model including incretin effect for precise identification of insulin sensitivity and secretion in a single individual.

    Directory of Open Access Journals (Sweden)

    Andrea De Gaetano

    Full Text Available In order to provide a method for precise identification of insulin sensitivity from clinical Oral Glucose Tolerance Test (OGTT observations, a relatively simple mathematical model (Simple Interdependent glucose/insulin MOdel SIMO for the OGTT, which coherently incorporates commonly accepted physiological assumptions (incretin effect and saturating glucose-driven insulin secretion has been developed. OGTT data from 78 patients in five different glucose tolerance groups were analyzed: normal glucose tolerance (NGT, impaired glucose tolerance (IGT, impaired fasting glucose (IFG, IFG+IGT, and Type 2 Diabetes Mellitus (T2DM. A comparison with the 2011 Salinari (COntinuos GI tract MOdel, COMO and the 2002 Dalla Man (Dalla Man MOdel, DMMO models was made with particular attention to insulin sensitivity indices ISCOMO, ISDMMO and kxgi (the insulin sensitivity index for SIMO. ANOVA on kxgi values across groups resulted significant overall (P<0.001, and post-hoc comparisons highlighted the presence of three different groups: NGT (8.62×10(-5±9.36×10(-5 min(-1pM(-1, IFG (5.30×10(-5±5.18×10(-5 and combined IGT, IFG+IGT and T2DM (2.09×10(-5±1.95×10(-5, 2.38×10(-5±2.28×10(-5 and 2.38×10(-5±2.09×10(-5 respectively. No significance was obtained when comparing ISCOMO or ISDMMO across groups. Moreover, kxgi presented the lowest sample average coefficient of variation over the five groups (25.43%, with average CVs for ISCOMO and ISDMMO of 70.32% and 57.75% respectively; kxgi also presented the strongest correlations with all considered empirical measures of insulin sensitivity. While COMO and DMMO appear over-parameterized for fitting single-subject clinical OGTT data, SIMO provides a robust, precise, physiologically plausible estimate of insulin sensitivity, with which habitual empirical insulin sensitivity indices correlate well. The kxgi index, reflecting insulin secretion dependency on glycemia, also significantly differentiates clinically

  14. EVIDENCE FOR A PHOTOSPHERIC COMPONENT IN THE PROMPT EMISSION OF THE SHORT GRB 120323A AND ITS EFFECTS ON THE GRB HARDNESS-LUMINOSITY RELATION

    Energy Technology Data Exchange (ETDEWEB)

    Guiriec, S.; McEnery, J.; Gehrels, N. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Daigne, F.; Hascoeet, R.; Mochkovitch, R. [Institut d' Astrophysique de Paris UMR 7095 Universite Pierre et Marie Curie-Paris 06 (France); CNRS 98 bis bd Arago, F-75014 Paris (France); Vianello, G. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Ryde, F. [Department of Physics, Royal Institute of Technology, AlbaNova, SE-106 91 Stockholm (Sweden); Kouveliotou, C. [Office of Science and Technology, ZP12, NASA/Marshall Space Flight Center, Huntsville, AL 35812 (United States); Xiong, S.; Bhat, P. N.; Burgess, J. M. [University of Alabama in Huntsville, NSSTC, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Foley, S.; McGlynn, S. [UCD School of Physics, University College Dublin, Dublin 4 (Ireland); Gruber, D., E-mail: sylvain.guiriec@nasa.gov [Max-Planck-Institut fuer extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching (Germany)

    2013-06-10

    The short GRB 120323A had the highest flux ever detected with the Gamma-Ray Burst Monitor on board the Fermi Gamma-Ray Space Telescope. Here we study its remarkable spectral properties and their evolution using two spectral models: (1) a single emission component scenario, where the spectrum is modeled by the empirical Band function (a broken power law), and (2) a two-component scenario, where thermal (a Planck-like function) emission is observed simultaneously with a non-thermal component (a Band function). We find that the latter model fits the integrated burst spectrum significantly better than the former, and that their respective spectral parameters are dramatically different: when fit with a Band function only, the E{sub peak} of the event is unusually soft for a short gamma-ray burst (GRB; 70 keV compared to an average of 300 keV), while adding a thermal component leads to more typical short GRB values (E{sub peak} {approx} 300 keV). Our time-resolved spectral analysis produces similar results. We argue here that the two-component model is the preferred interpretation for GRB 120323A based on (1) the values and evolution of the Band function parameters of the two component scenario, which are more typical for a short GRB, and (2) the appearance in the data of a significant hardness-intensity correlation, commonly found in GRBs, when we employee two-component model fits; the correlation is non-existent in the Band-only fits. GRB 110721A, a long burst with an intense photospheric emission, exhibits the exact same behavior. We conclude that GRB 120323A has a strong photospheric emission contribution, observed for the first time in a short GRB. Magnetic dissipation models are difficult to reconcile with these results, which instead favor photospheric thermal emission and fast cooling synchrotron radiation from internal shocks. Finally, we derive a possibly universal hardness-luminosity relation in the source frame using a larger set of GRBs (L{sub i}{sup Band

  15. Association of Neutralization Sensitivity of HIV- 1 Primary Isolates With Biological Properties of Isolates From HIV-1 Infected Chinese Individuals

    Institute of Scientific and Technical Information of China (English)

    FA-XIN HEI; HAI-LI TANG; KUN-XUE HONG; JIAN-PING CHEN; HONG PENG; LIN YUAN; JIANG-QING XU; YI-MING SHAO

    2005-01-01

    Objective Although HIV-1 infection is prevalent in many regions in China, it remains largely unknown on the biological characteristics of dominant circulating isolates. This study was designed to isolate the circulating viral strains from different prevalent regions and to characterize their biological properties and neutralization sensitivity. Methods Primary viruses were isolated from fresh PBMCs using the traditional co-culture method and their capacity of inducing syncytium was tested in MT-2 cells. Meanwhile, their coreceptor usage was determined with two cell lines: Magi and GHOST (3) stably expressing CD4 and the chemokine receptor CCR5 or CXCR4. Furthermore, the sensitivity of these viruses to neutralization by HIV-1-infected patients' plasma which were highly active to neutralize SF33 strain, was quantified in GHOST cell-based neutralization assay. Results Six primary viral strains were isolated from 4 separated regions. Isolates LTG0213,LTG0214 and XVS032691 induced syncytia in MT-2 cells, and used CXCR4 as coreceptor. Isolates XJN0021, XJN0091, or SHXDC0041 did not induce syncytia, and used CCR5 as coreceptor. Overall neutralization sensitivity differed among four representative strains: HIV-1 XVS032691>LTG0214>XJN0091≈SHXDC0041. Conclusion The neutralization sensitivity of HIV isolates is linked with the phenotype of isolates, in which syncytium-inducing (SI) or CXCR4-tropic (X4) viruses are more easily neutralized than non-syncytium-inducing (NSI) or CCR5-tropic (R5) viruses. The genetic subtypes based on the phylogeny of env sequences are not classical neutralization serotypes.

  16. Disrupted Stimulus Control but Not Reward Sensitivity in Individuals with Autism Spectrum Disorders: A Matching Law Analysis

    Science.gov (United States)

    Reed, Phil; Hawthorn, Rose; Bolger, Sam; Meredith, Katie; Bishop, Ruth

    2012-01-01

    The matching law suggests that behavior is emitted in proportion to the level of reinforcement available. The current study investigated this effect in individuals with autism spectrum disorders (ASD), and focused on the effects of magnitude of reinforcement (Study 1), and rate of reinforcement (Studies 2 and 3), on matching performance. Studies 1…

  17. Are Perfectionism, Individualism, and Racial Color-Blindness Associated with Less Cultural Sensitivity? Exploring Diversity Awareness in White Prospective Teachers

    Science.gov (United States)

    Wang, Kenneth T.; Castro, Antonio J.; Cunningham, Yu Li

    2014-01-01

    Cultural ideologies of meritocracy and individualism act as strong barriers for college students in understanding the most complex systems of inequity across racial, cultural, and gendered lines. The dichotomous thinking patterns of maladaptive perfectionists may also relate to resistance of multicultural awareness. This study examined whether…

  18. Are Perfectionism, Individualism, and Racial Color-Blindness Associated with Less Cultural Sensitivity? Exploring Diversity Awareness in White Prospective Teachers

    Science.gov (United States)

    Wang, Kenneth T.; Castro, Antonio J.; Cunningham, Yu Li

    2014-01-01

    Cultural ideologies of meritocracy and individualism act as strong barriers for college students in understanding the most complex systems of inequity across racial, cultural, and gendered lines. The dichotomous thinking patterns of maladaptive perfectionists may also relate to resistance of multicultural awareness. This study examined whether…

  19. The Role of the L1 and Individual Differences in L2 Sensitivity to Morphosyntactic Features: An ERP Investigation

    Science.gov (United States)

    Bond, Kristi

    2013-01-01

    This study used ERP (event-related potentials) to examine both the role of the L1 and the role of individual differences in the processing of agreement violations. Theories of L2 acquisition differ with regard to whether or not native-like acquisition of L2 features is possible (Schwartz and Sprouse, 1994, 1996; Tsimpli and Mastropavlou, 2007),…

  20. GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production.

    Science.gov (United States)

    Bilal, Mahmood Yousif; Houtman, Jon C D

    2015-01-01

    GRB2 is a ubiquitously expressed adaptor protein required for signaling downstream of multiple receptors. To address the role of GRB2 in receptor-mediated signaling, the expression of GRB2 was suppressed in human CD4+ T cells and its role downstream of the T cell receptor (TCR) was examined. Interestingly, GRB2 deficient T cells had enhanced signaling from complexes containing the TCR. However, GRB2 deficient T cells had substantially reduced production of IL-2 and IFN-γ. This defect was attributed to diminished formation of linker for activation of T cells (LAT) signaling clusters, which resulted in reduced MAP kinase activation, calcium flux, and PLC-γ1 recruitment to LAT signaling clusters. Add back of wild-type GRB2, but not a novel N-terminal SH3 domain mutant, rescued LAT microcluster formation, calcium mobilization, and cytokine release, providing the first direct evidence that GRB2, and its ability to bind to SH3 domain ligands, is required for establishing LAT microclusters. Our data demonstrate that the ability of GRB2 to facilitate protein clusters is equally important in regulating TCR-mediated functions as its capacity to recruit effector proteins. This highlights that GRB2 regulates signaling downstream of adaptors and receptors by both recruiting effector proteins and regulating the formation of signaling complexes.

  1. Method for detecting neutrinos from internal shocks in GRB fireballs with AMANDA

    CERN Document Server

    Stamatikos, M

    2004-01-01

    Neutrino-based astronomy provides a new window on the most energetic processes in the universe. The discovery of high-energy (E >or= 10 /sup 14/ eV) muonic neutrinos (v/sub mu /) from gamma-ray bursts (GRBs) would confirm hadronic acceleration in the relativistic GRB- wind, validate the phenomenology of the canonical fireball model and possibly reveal an acceleration mechanism for the highest energy cosmic rays (CRs). The Antarctic Muon and Neutrino Detector Array (AMANDA) is the world's largest operational neutrino telescope with a PeV muon effective area (averaged over zenith angle) ~ 50,000 m/sup 2 /. AMANDA uses the natural ice at the geographic South Pole as a Cherenkov medium and has been successfully calibrated on the signal of atmospheric neutrinos (v/sub atm/). Contrary to previous diffuse searches, we describe an analysis based upon confronting AMANDA observations of individual GRBs, adequately modeled by fireball phenomenology, with the predictions of the canonical fireball model. The expected neut...

  2. On the sensitivity of the HAWC observatory to gamma-ray bursts

    CERN Document Server

    Abeysekara, A U; Aguilar, S; Alfaro, R; Almaraz, E; Álvarez, C; Álvarez-Romero, J de D; Álvarez, M; Arceo, R; Arteaga-Velázquez, J C; Badillo, C; Barber, A; Baughman, B M; Bautista-Elivar, N; Belmont, E; Benítez, E; BenZvi, S Y; Berley, D; Bernal, A; Bonamente, E; Braun, J; Caballero-Lopez, R; Cabrera, I; Carramiñana, A; Carrasco, L; Castillo, M; Chambers, L; Conde, R; Condreay, P; Cotti, U; Cotzomi, J; D'Olivo, J C; de la Fuente, E; De León, C; Delay, S; Delepine, D; DeYoung, T; Diaz, L; Diaz-Cruz, L; Dingus, B L; Duvernois, M A; Edmunds, D; Ellsworth, R W; Fick, B; Fiorino, D W; Flandes, A; Fraija, N I; Galindo, A; García-Luna, J L; García-Torales, G; Garfias, F; González, L X; González, M M; Goodman, J A; Grabski, V; Gussert, M; Guzmán-Ceron, C; Hampel-Arias, Z; Harris, T; Hays, E; Hernandez-Cervantes, L; Hüntemeyer, P H; Imran, A; Iriarte, A; Jimenez, J J; Karn, P; Kelley-Hoskins, N; Kieda, D; Langarica, R; Lara, A; Lauer, R; Lee, W H; Linares, E C; Linnemann, J T; Longo, M; Luna-García, R; Martínez, H; Martínez, J; Martínez, L A; Martínez, O; Martínez-Castro, J; Martos, M; Matthews, J; McEnery, J E; Medina-Tanco, G; Mendoza-Torres, J E; Miranda-Romagnoli, P A; Montaruli, T; Moreno, E; Mostafa, M; Napsuciale, M; Nava, J; Nellen, L; Newbold, M; Noriega-Papaqui, R; Oceguera-Becerra, T; Tapia, A Olmos; Orozco, V; Pérez, V; Pérez-Pérez, E G; Perkins, J S; Pretz, J; Ramirez, C; Ramírez, I; Rebello, D; Rentería, A; Reyes, J; Rosa-González, D; Rosado, A; Ryan, J M; Sacahui, J R; Salazar, H; Salesa, F; Sandoval, A; Santos, E; Schneider, M; Shoup, A; Silich, S; Sinnis, G; Smith, A J; Sparks, K; Springer, W; Suárez, F; Suarez, N; Taboada, I; Tellez, A F; Tenorio-Tagle, G; Tepe, A; Toale, P A; Tollefson, K; Torres, I; Ukwatta, T N; Valdes-Galicia, J; Vanegas, P; Vasileiou, V; Vázquez, O; Vázquez, X; Villaseñor, L; Wall, W; Walters, J S; Warner, D; Westerhoff, S; Wisher, I G; Wood, J; Yodh, G B; Zaborov, D; Zepeda, A

    2011-01-01

    We present the sensitivity of HAWC to Gamma Ray Bursts (GRBs). HAWC is a very high-energy gamma-ray observatory currently under construction in Mexico at an altitude of 4100 m. It will observe atmospheric air showers via the water Cherenkov method. HAWC will consist of 300 large water tanks instrumented with 4 photomultipliers each. HAWC has two data acquisition (DAQ) systems. The main DAQ system reads out coincident signals in the tanks and reconstructs the direction and energy of individual atmospheric showers. The scaler DAQ counts the hits in each photomultiplier tube (PMT) in the detector and searches for a statistical excess over the noise of all PMTs. We show that HAWC has a realistic opportunity to observe the high-energy power law components of GRBs that extend at least up to 30 GeV, as it has been observed by Fermi LAT. The two DAQ systems have an energy threshold that is low enough to observe events similar to GRB 090510 and GRB 090902b with the characteristics observed by Fermi LAT. HAWC will prov...

  3. Nickel-induced cytokine production from mononuclear cells in nickel-sensitive individuals and controls. Cytokine profiles in nickel-sensitive individuals with nickel allergy-related hand eczema before and after nickel challenge

    DEFF Research Database (Denmark)

    Borg, L; Christensen, J M; Kristiansen, J

    2000-01-01

    Exposure to nickel is a major cause of allergic contact dermatitis which is considered to be an inflammatory response induced by antigen-specific T cells. Here we describe the in vitro analysis of the nickel-specific T-cell-derived cytokine response of peripheral blood mononuclear cells from 35...... was somewhat of a surprise, since previous studies have suggested a Th1 response in nickel-mediated allergic contact dermatitis. Subsequently, the nickel-allergic individuals were randomized to experimental exposure to nickel or vehicle in a double-blind design. A daily 10-min exposure of one finger to 10 ppm...... nickel solution for 1 week followed by 100 ppm for an additional week evoked a clinical response of hand eczema in the nickel-exposed group. Blood samples were drawn on days 7 and 14 after the start of this exposure to occupationally relevant concentrations of nickel. No statistically significant...

  4. From individual coping strategies to illness codification: the reflection of gender in social science research on multiple chemical sensitivities (MCS).

    Science.gov (United States)

    Nadeau, Geneviève; Lippel, Katherine

    2014-09-10

    Emerging fields such as environmental health have been challenged, in recent years, to answer the growing methodological calls for a finer integration of sex and gender in health-related research and policy-making. Through a descriptive examination of 25 peer-reviewed social science papers published between 1996 and 2011, we explore, by examining methodological designs and theoretical standpoints, how the social sciences have integrated gender sensitivity in empirical work on Multiple Chemical Sensitivities (MCS). MCS is a "diagnosis" associated with sensitivities to chronic and low-dose chemical exposures, which remains contested in both the medical and institutional arenas, and is reported to disproportionately affect women. We highlighted important differences between papers that did integrate a gender lens and those that did not. These included characteristics of the authorship, purposes, theoretical frameworks and methodological designs of the studies. Reviewed papers that integrated gender tended to focus on the gender roles and identity of women suffering from MCS, emphasizing personal strategies of adaptation. More generally, terminological confusions in the use of sex and gender language and concepts, such as a conflation of women and gender, were observed. Although some men were included in most of the study samples reviewed, specific data relating to men was undereported in results and only one paper discussed issues specifically experienced by men suffering from MCS. Papers that overlooked gender dimensions generally addressed more systemic social issues such as the dynamics of expertise and the medical codification of MCS, from more consistently outlined theoretical frameworks. Results highlight the place for a critical, systematic and reflexive problematization of gender and for the development of methodological and theoretical tools on how to integrate gender in research designs when looking at both micro and macro social dimensions of environmental

  5. CONSTRAINING THE GRB-MAGNETAR MODEL BY MEANS OF THE GALACTIC PULSAR POPULATION

    Energy Technology Data Exchange (ETDEWEB)

    Rea, N. [Anton Pannekoek Institute for Astronomy, University of Amsterdam, Postbus 94249, NL-1090 GE Amsterdam (Netherlands); Gullón, M.; Pons, J. A.; Miralles, J. A. [Departament de Fisica Aplicada, Universitat d’Alacant, Ap. Correus 99, E-03080 Alacant (Spain); Perna, R. [Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY 11794 (United States); Dainotti, M. G. [Physics Department, Stanford University, Via Pueblo Mall 382, Stanford, CA (United States); Torres, D. F. [Instituto de Ciencias de l’Espacio (ICE, CSIC-IEEC), Campus UAB, Carrer Can Magrans s/n, E-08193 Barcelona (Spain)

    2015-11-10

    A large fraction of Gamma-ray bursts (GRBs) displays an X-ray plateau phase within <10{sup 5} s from the prompt emission, proposed to be powered by the spin-down energy of a rapidly spinning newly born magnetar. In this work we use the properties of the Galactic neutron star population to constrain the GRB-magnetar scenario. We re-analyze the X-ray plateaus of all Swift GRBs with known redshift, between 2005 January and 2014 August. From the derived initial magnetic field distribution for the possible magnetars left behind by the GRBs, we study the evolution and properties of a simulated GRB-magnetar population using numerical simulations of magnetic field evolution, coupled with Monte Carlo simulations of Pulsar Population Synthesis in our Galaxy. We find that if the GRB X-ray plateaus are powered by the rotational energy of a newly formed magnetar, the current observational properties of the Galactic magnetar population are not compatible with being formed within the GRB scenario (regardless of the GRB type or rate at z = 0). Direct consequences would be that we should allow the existence of magnetars and “super-magnetars” having different progenitors, and that Type Ib/c SNe related to Long GRBs form systematically neutron stars with higher initial magnetic fields. We put an upper limit of ≤16 “super-magnetars” formed by a GRB in our Galaxy in the past Myr (at 99% c.l.). This limit is somewhat smaller than what is roughly expected from Long GRB rates, although the very large uncertainties do not allow us to draw strong conclusion in this respect.

  6. Supplementation of Diet With Galacto-oligosaccharides Increases Bifidobacteria, but Not Insulin Sensitivity, in Obese Prediabetic Individuals

    DEFF Research Database (Denmark)

    Canfora, Emanuel E; van der Beek, Christina M; Hermes, Gerben D A

    2017-01-01

    in these processes. We investigated the long-term effects of supplementation with galacto-oligosaccharides (GOS), an acetogenic fiber, on the composition of the human gut microbiota and human metabolism. METHODS: We performed a double-blinded, placebo-controlled, parallel intervention study of 44 overweight or obese......BACKGROUND & AIMS: The gut microbiota affects host lipid and glucose metabolism, satiety, and chronic low-grade inflammation to contribute to obesity and type 2 diabetes. Fermentation end products, in particular the short-chain fatty acid (SCFA) acetate, are believed to be involved....... Before and after this period, we collected data on peripheral and adipose tissue insulin sensitivity, fecal microbiota composition, plasma and fecal SCFA, energy expenditure and substrate oxidation, body composition, and hormonal and inflammatory responses. The primary outcome was the effect of GOS...

  7. Evidence for a Photospheric Component in the Prompt Emission of the Short GRB120323A and its Effects on the GRB Hardness-Luminosity Relation

    CERN Document Server

    Guiriec, S; Hascoët, R; Vianello, G; Mochkovitch, R; Ryde, F; Kouveliotou, C; Xiong, S; Bhat, P N; Foley, S; Grüber, D; Burgess, J M; McGlynn, S; McEnery, J; Gehrels, N

    2012-01-01

    The short GRB 120323A had the highest flux ever detected with the Fermi/GBM. Here we study its remarkable spectral properties and their evolution using two spectral models: (i) a single emission component scenario, where the spectrum is modeled by the empirical Band function, and (ii) a two component scenario, where thermal (Planck-like) emission is observed simultaneously with a non-thermal component (a Band function). We find that the latter model fits the integrated burst spectrum significantly better than the former, and that their respective spectral parameters are dramatically different: when fit with a Band function only, the Epeak of the event is unusually soft for a short GRB, while adding a thermal component leads to more typical short GRB values. Our time-resolved spectral analysis produces similar results. We argue here that the two-component model is the preferred interpretation for GRB 120323A, based on: (i) the values and evolution of the Band function parameters of the two component scenario, ...

  8. Dose-response relationship of baroreflex sensitivity and heart rate variability to individually-tailored exercise training in patients with heart failure.

    Science.gov (United States)

    Iellamo, Ferdinando; Manzi, Vincenzo; Caminiti, Giuseppe; Sposato, Barbara; Massaro, Michele; Cerrito, Anna; Rosano, Giuseppe; Volterrani, Maurizio

    2013-06-20

    Heart Rate Variability (HRV) and Baroreflex Sensitivity (BRS) are impaired in patients with Chronic Heart Failure (CHF) and carry negative prognosis. Exercise training improves these parameters. However, the relationship between exercise training with HRV and BRS has been investigated without regard for individual training loads. We tested the hypothesis that in CHF patients changes in HRV and BRS are dose-response related to individual volume/intensity training load (TL). Twenty patients with stable postinfarction CHF under optimal medical treatment were randomized to either aerobic continuous training (ACT) or aerobic interval training (AIT) for 12weeks. Individualized TL was monitored by the Training Impulses (TRIMPi) method, which was determined using the individual HR and lactate profiling determined during a treadmill test at baseline. HRV (standard deviation of mean R-R interval) and BRS were assessed at rest and 3weeks apart, throughout the study. HRV, BRS and R-R interval increased significantly with training, being very highly correlated to the dose of exercise with a second-order regression model (r(2) ranged from 0.75 to 0.96; Pincrease in functional capacity. No significant differences were detected between ACT and AIT in any variable. These results suggest that improvements in HRV and BRS by exercise training in CHF patients are dose related to TL in a non-linear fashion on an individual basis, with optimal results at moderate doses of exercise. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  9. Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis.

    Science.gov (United States)

    Radtke, Daniel; Lacher, Sonja M; Szumilas, Nadine; Sandrock, Lena; Ackermann, Jochen; Nitschke, Lars; Zinser, Elisabeth

    2016-04-01

    The small adaptor protein growth factor receptor-bound protein 2 (Grb2) modulates and integrates signals from receptors on cellular surfaces in inner signaling pathways. In murine T cells, Grb2 is crucial for amplification of TCR signaling. T cell-specific Grb2(fl/fl) Lckcre(tg) Grb2-deficient mice show reduced T cell numbers due to impaired negative and positive selection. In this study, we found that T cell numbers in Grb2(fl/fl) CD4cre(tg) mice were normal in the thymus and were only slightly affected in the periphery. Ex vivo analysis of CD4(+) Th cell populations revealed an increased amount of Th1 cells within the CD4(+) population of Grb2(fl/fl) CD4cre(tg) mice. Additionally, Grb2-deficient T cells showed a greater potential to differentiate into Th17 cells in vitro. To test whether these changes in Th cell differentiation potential rendered Grb2(fl/fl) CD4cre(tg) mice more prone to inflammatory diseases, we used the murine Th1 cell- and Th17 cell-driven model of experimental autoimmune encephalomyelitis (EAE). In contrast to our expectations, Grb2(fl/fl) CD4cre(tg) mice developed a milder form of EAE. The impaired EAE disease can be explained by the reduced proliferation rate of Grb2-deficient CD4(+) T cells upon stimulation with IL-2 or upon activation by allogeneic dendritic cells, because the activation of T cells by dendritic cells and the subsequent T cell proliferation are known to be crucial factors for the induction of EAE. In summary, Grb2-deficient T cells show defects in T cell development, increased Th1 and Th17 cell differentiation capacities, and impaired proliferation after activation by dendritic cells, which likely reduce the clinical symptoms of EAE.

  10. The development of a low energy Compton imager for GRB polarization studies

    Science.gov (United States)

    McConnell, Mark L.; Bloser, Peter F.; Legere, Jason S.; Ryan, James M.

    2016-07-01

    Theoretical models show that a more complete understanding of the inner structure of -ray bursts (GRBs), including the geometry and physical processes close to the central engine, requires the exploitation of -ray polarimetry. Over the past several years, we have developed the Gamma Ray Polarization Experiment (GRAPE) to measure the polarization of -rays from GRBs over the energy range of 50 to 500 keV. GRAPE is a large FoV instrument with a sensitive energy range covering the peak energy distribution of GRBs. The design is based on an array of independent modules, each of which consists of an array of (high-Z and low-Z) scintillator elements read out by a multi-anode PMT (MAPMT). Our eventual goal is to y GRAPE on a long duration balloon (LDB) platform to collect data on a significant sample of GRBs. Our experience with two balloon flights (in 2011 and 2014), coupled with further design efforts focused on orbital payloads, has led to an improved polarimeter concept that represents a natural evolution of the current design. The new concept employs a large number of optically-isolated scintillator elements, each of which is designed to provide a depth-of-interaction (DOI) using two (or perhaps more) readout sensors. The resulting three-dimensional location data provides a moderate level of Compton imaging capability (1 angular resolution of 10 - 15°. Even this level of imaging can be used to significantly reduce the instrumental background by limiting the impact of the cosmic diffuse flux, dramatically improving the polarization sensitivity. Here we shall describe this concept and the expected performance for GRB polarization measurements.

  11. Humoral and Cell-mediated Autoimmune Reactions to Human Acidic Ribosomal P2 Protein in Individuals Sensitized to Aspergillus fumigatus P2 Protein

    Science.gov (United States)

    Mayer, Christina; Appenzeller, Ulrich; Seelbach, Heike; Achatz, Gernot; Oberkofler, Hannes; Breitenbach, Michael; Blaser, Kurt; Crameri, Reto

    1999-01-01

    A panel of cDNAs encoding allergenic proteins was isolated from an Aspergillus fumigatus cDNA library displayed on the surface of filamentous phage. Solid phase–immobilized serum immunoglobulin E (IgE) from A. fumigatus–allergic individuals was used to enrich phage displaying IgE-binding molecules. One of the cDNAs encoded a 11.1-kD protein that was identified as acidic ribosomal phosphoprotein type 2 (P2 protein). The allergen, formally termed rAsp f 8, shares >62% sequence identity and >84% sequence homology to corresponding eukaryotic P2 proteins, including human P2 protein. The sequences encoding human and fungal P2 protein were subcloned, expressed in Escherichia coli as His6-tagged fusion proteins, and purified by Ni2+–chelate affinity chromatography. Both recombinant P2 proteins were recognized by IgE antibodies from allergic individuals sensitized to the A. fumigatus P2 protein and elicited strong type 1–specific skin reactions in these individuals. Moreover, human and fungal P2 proteins induced proliferative responses in peripheral blood mononuclear cells of A. fumigatus– allergic subjects sensitized to the fungal P2 protein. These data provide strong evidence for in vitro and in vivo humoral and cell-mediated autoreactivity to human P2 protein in patients suffering from chronic A. fumigatus allergy. PMID:10224291

  12. Virtual patients and sensitivity analysis of the Guyton model of blood pressure regulation: towards individualized models of whole-body physiology.

    Directory of Open Access Journals (Sweden)

    Robert Moss

    Full Text Available Mathematical models that integrate multi-scale physiological data can offer insight into physiological and pathophysiological function, and may eventually assist in individualized predictive medicine. We present a methodology for performing systematic analyses of multi-parameter interactions in such complex, multi-scale models. Human physiology models are often based on or inspired by Arthur Guyton's whole-body circulatory regulation model. Despite the significance of this model, it has not been the subject of a systematic and comprehensive sensitivity study. Therefore, we use this model as a case study for our methodology. Our analysis of the Guyton model reveals how the multitude of model parameters combine to affect the model dynamics, and how interesting combinations of parameters may be identified. It also includes a "virtual population" from which "virtual individuals" can be chosen, on the basis of exhibiting conditions similar to those of a real-world patient. This lays the groundwork for using the Guyton model for in silico exploration of pathophysiological states and treatment strategies. The results presented here illustrate several potential uses for the entire dataset of sensitivity results and the "virtual individuals" that we have generated, which are included in the supplementary material. More generally, the presented methodology is applicable to modern, more complex multi-scale physiological models.

  13. Virtual patients and sensitivity analysis of the Guyton model of blood pressure regulation: towards individualized models of whole-body physiology.

    Science.gov (United States)

    Moss, Robert; Grosse, Thibault; Marchant, Ivanny; Lassau, Nathalie; Gueyffier, François; Thomas, S Randall

    2012-01-01

    Mathematical models that integrate multi-scale physiological data can offer insight into physiological and pathophysiological function, and may eventually assist in individualized predictive medicine. We present a methodology for performing systematic analyses of multi-parameter interactions in such complex, multi-scale models. Human physiology models are often based on or inspired by Arthur Guyton's whole-body circulatory regulation model. Despite the significance of this model, it has not been the subject of a systematic and comprehensive sensitivity study. Therefore, we use this model as a case study for our methodology. Our analysis of the Guyton model reveals how the multitude of model parameters combine to affect the model dynamics, and how interesting combinations of parameters may be identified. It also includes a "virtual population" from which "virtual individuals" can be chosen, on the basis of exhibiting conditions similar to those of a real-world patient. This lays the groundwork for using the Guyton model for in silico exploration of pathophysiological states and treatment strategies. The results presented here illustrate several potential uses for the entire dataset of sensitivity results and the "virtual individuals" that we have generated, which are included in the supplementary material. More generally, the presented methodology is applicable to modern, more complex multi-scale physiological models.

  14. Increased sensitivity to physical activity among individuals with knee osteoarthritis: relation to pain outcomes, psychological factors, and responses to quantitative sensory testing.

    Science.gov (United States)

    Wideman, Timothy H; Finan, Patrick H; Edwards, Robert R; Quartana, Phillip J; Buenaver, Luis F; Haythornthwaite, Jennifer A; Smith, Michael T

    2014-04-01

    Recent findings suggest that certain individuals with musculoskeletal pain conditions have increased sensitivity to physical activity (SPA) and respond to activities of stable intensity with increasingly severe pain. This study aimed to determine the degree to which individuals with knee osteoarthritis (OA) show heightened SPA in response to a standardized walking task and whether SPA cross-sectionally predicts psychological factors, responses to quantitative sensory testing (QST), and different OA-related outcomes. One hundred seven adults with chronic knee OA completed self-report measures of pain, function, and psychological factors, underwent QST, and performed a 6-min walk test. Participants rated their discomfort levels throughout the walking task; an index of SPA was created by subtracting first ratings from peak ratings. Repeated-measure analysis of variance revealed that levels of discomfort significantly increased throughout the walking task. A series of hierarchical regression analyses determined that after controlling for significant covariates, psychological factors, and measures of mechanical pain sensitivity, individual variance in SPA predicted self-report pain and function and performance on the walking task. Analyses also revealed that both pain catastrophizing and the temporal summation of mechanical pain were significant predictors of SPA and that SPA mediated the relationship between catastrophizing and self-reported pain and physical function. The discussion addresses the potential processes contributing to SPA and the role it may play in predicting responses to different interventions for musculoskeletal pain conditions.

  15. Circadian exosomal expression of renal thiazide-sensitive NaCl cotransporter (NCC) and prostasin in healthy individuals.

    Science.gov (United States)

    Castagna, Annalisa; Pizzolo, Francesca; Chiecchi, Laura; Morandini, Francesca; Channavajjhala, Sarath Kiran; Guarini, Patrizia; Salvagno, Gianluca; Olivieri, Oliviero

    2015-06-01

    A circadian timing system is involved in the maintenance of fluid and electrolyte balance and blood pressure control. Aldosterone and vasopressin modulate ion transporters and channels crucial in sodium (Na) and water reabsorption such as the epithelium Na channel and the renal thiazide-sensitive NaCl cotransporter (NCC). We analyzed in urinary exosomes the intraday variations of NCC and prostasin expression and the association with electrolytes and water balance parameters. Blood and urine samples were collected at five time points during the day from five healthy subjects. Blood renin, aldosterone, cortisol, ACTH, and plasmatic and urinary Na, potassium, creatinine, adiuretin (ADH), NCC, and prostasin were evaluated. ACTH and cortisol showed a circadian pattern, similarly to aldosterone, while exosomal NCC and prostasin pattern were similar to urinary ADH, decreased in the morning and subsequently increased in the afternoon and evening. In urinary exosomes, NCC and prostasin had a diurnal pattern parallel to ADH and aquaporin 2, confirming that, in healthy subjects, both prostasin and NCC relate to water balance. These results provide suggestions for a possible chronotherapeutic approach in patients treated with thiazides, diuretic drugs acting as specific inhibitors of NCC-mediated Na reabsorption. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Anatomy of A Dark Burst - The Afterglow of GRB 060108

    CERN Document Server

    Oates, S R; Piranomonte, S; Page, K L; De Pasquale, M; Monfardini, A; Melandri, A; Zane, S; Guidorzi, C; Malesani, D; Gomboc, A; Bannister, N; Blustin, A J; Capalbi, M; Carter, D; D'Avanzo, P; Kobayashi, S; Krimm, H A; O'Brien, P T; Page, M J; Smith, R J; Steele, I A; Tanvir, N

    2006-01-01

    We report the first detection of an optical afterglow of a GRB (060108) that would have been classified as 'dark' in the absence of deep, rapid ground-based optical imaging with the 2-m robotic Faulkes Telesscope (FTN). Our multiwavelength analysis reveals an X-ray light curve typical of many Swift long GRBs (3-segments plus flare). Its optical afterglow, however, was already fainter than the detection limit of the UVOT within 100s of the burst. Optical imaging in BVRi' filters with the FTN began 2.75 minutes after the burst and resulted in the detection of the optical afterglow at 5.3 minutes, with a UKIRT K-band identification at ~45 mins. R and i'-band light curves are consistent with a single power law decay in flux, F(t) prop t^-a where a=0.43+/-0.08, or a 2-segment light curve with a steep decay a_1 <0.88, flattening to a_2 ~ 0.31, with evidence for rebrightening at i' band. Deep VLT R-band imaging at ~12 days reveals a faint, extended object (R ~23.5 mag) at the location of the afterglow. Although t...

  17. GRB physics and cosmology with peak energy-intensity correlations

    Energy Technology Data Exchange (ETDEWEB)

    Sawant, Disha, E-mail: sawant@fe.infn.it [University of Ferrara, Via Saragat-1, Block C, Ferrara 44122 (Italy); University of Nice, 28 Avenue Valrose, Nice 06103 (France); IRAP Erasmus PhD Program, European Union and INAF - IASF Bologna, Via P. Gobetti 101, Bologna 41125 (Italy); Amati, Lorenzo, E-mail: amati@iasfbo.inaf.it [INAF - IASF Bologna, Via P. Gobetti 101, Bologna 41125 (Italy); ICRANet, Piazzale Aldo Moro-5, Rome 00185 (Italy)

    2015-12-17

    Gamma Ray Bursts (GRBs) are immensely energetic explosions radiating up to 10{sup 54} erg of energy isotropically (E{sub iso}) and they are observed within a wide range of redshift (from ∼ 0.01 up to ∼ 9). Such enormous power and high redshift point at these phenomena being highly favorable to investigate the history and evolution of our universe. The major obstacle in their application as cosmological study-tools is to find a way to standardize the GRBs, for instance similar to SNe Ia. With respect to this goal, the correlation between spectral peak energy (E{sub p,i}) and the “intensity” is a positively useful and investigated criterion. Moreover, it has been demonstrated that, through the E{sub p,i} – E{sub iso} correlation, the current data set of GRBs can already contribute to the independent evidence of the matter density Ω{sub M} being ∼ 0.3 for a flat universe scenario. We try to inspect and compare the correlations of E{sub p,i} with different intensity indicators (e.g., radiated energy, average and peak luminosity, bolometric vs. monochromatic quantities, etc.) both in terms of intrinsic dispersion and precise estimation of Ω{sub M}. The outcome of such studies are further analyzed in verifying the reliability of the correlations for both GRB physics and their standardization for cosmology.

  18. GRB physics and cosmology with peak energy-intensity correlations

    Science.gov (United States)

    Sawant, Disha; Amati, Lorenzo

    2015-12-01

    Gamma Ray Bursts (GRBs) are immensely energetic explosions radiating up to 1054 erg of energy isotropically (Eiso) and they are observed within a wide range of redshift (from ˜ 0.01 up to ˜ 9). Such enormous power and high redshift point at these phenomena being highly favorable to investigate the history and evolution of our universe. The major obstacle in their application as cosmological study-tools is to find a way to standardize the GRBs, for instance similar to SNe Ia. With respect to this goal, the correlation between spectral peak energy (Ep,i) and the "intensity" is a positively useful and investigated criterion. Moreover, it has been demonstrated that, through the Ep,i - Eiso correlation, the current data set of GRBs can already contribute to the independent evidence of the matter density ΩM being ˜ 0.3 for a flat universe scenario. We try to inspect and compare the correlations of Ep,i with different intensity indicators (e.g., radiated energy, average and peak luminosity, bolometric vs. monochromatic quantities, etc.) both in terms of intrinsic dispersion and precise estimation of ΩM. The outcome of such studies are further analyzed in verifying the reliability of the correlations for both GRB physics and their standardization for cosmology.

  19. The afterglow and the host galaxy of GRB 011211

    CERN Document Server

    Jakobsson, P; Fynbo, J P U; Gorosabel, J; Pedersen, K; Burud, I; Levan, A J; Kouveliotou, C; Tanvir, N R; Fruchter, A S; Rhoads, J; Grav, T; Hansen, M W; Michelsen, R; Andersen, M I; Jensen, B L; Pedersen, H; Thomsen, B; Weidinger, M; Bhargavi, S G; Cowsik, R; Pandey, S B

    2003-01-01

    We present optical, near-infrared, and X-ray observations of the optical afterglow (OA) of the X-ray rich, long-duration gamma-ray burst GRB 011211. Hubble Space Telescope (HST) data obtained 14, 26, 32, and 59 days after the burst, show the host galaxy to have a morphology that is fairly typical of blue galaxies at high redshift. We measure its magnitude to be R = 24.95 +/- 0.11. We detect a break in the OA R-band light curve which is naturally accounted for by a collimated outflow geometry. By fitting a broken power-law to the data we find a best fit with a break 1.56 +/- 0.02 days after the burst, a pre-break slope of alpha_1 = -0.95 +/- 0.02, and a post-break slope of alpha_2 = -2.11 +/- 0.07. The UV-optical spectral energy distribution (SED) around 14 hours after the burst is best fit with a power-law with index beta = -0.56 +/- 0.19 reddened by an SMC-like extinction law with a modest A_V = 0.08 +/- 0.08 mag. By comparison, from the XMM-Newton X-ray data at around the same time, we find a decay index of...

  20. Nonlinear Particle Acceleration and Thermal Particles in GRB Afterglows

    Science.gov (United States)

    Warren, Donald C.; Ellison, Donald C.; Barkov, Maxim V.; Nagataki, Shigehiro

    2017-02-01

    The standard model for GRB afterglow emission treats the accelerated electron population as a simple power law, N(E)\\propto {E}-p for p≳ 2. However, in standard Fermi shock acceleration, a substantial fraction of the swept-up particles do not enter the acceleration process at all. Additionally, if acceleration is efficient, then the nonlinear back-reaction of accelerated particles on the shock structure modifies the shape of the nonthermal tail of the particle spectra. Both of these modifications to the standard synchrotron afterglow impact the luminosity, spectra, and temporal variation of the afterglow. To examine the effects of including thermal particles and nonlinear particle acceleration on afterglow emission, we follow a hydrodynamical model for an afterglow jet and simulate acceleration at numerous points during the evolution. When thermal particles are included, we find that the electron population is at no time well fitted by a single power law, though the highest-energy electrons are; if the acceleration is efficient, then the power-law region is even smaller. Our model predicts hard–soft–hard spectral evolution at X-ray energies, as well as an uncoupled X-ray and optical light curve. Additionally, we show that including emission from thermal particles has drastic effects (increases by factors of 100 and 30, respectively) on the observed flux at optical and GeV energies. This enhancement of GeV emission makes afterglow detections by future γ-ray observatories, such as CTA, very likely.

  1. An external-shock model for GRB afterglow 130427A

    CERN Document Server

    Panaitescu, A; Wozniak, P

    2013-01-01

    The complex multiwavelength emission of GRB afterglow 130427A (monitored in the radio up to 10 days, in the optical and X-ray until 50 days, and at GeV energies until 1 day) can be accounted for by a hybrid reverse-forward shock synchrotron model, with inverse-Compton emerging only above a few GeV. The high ratio of the early optical to late radio flux requires that the ambient medium is a wind and that the forward-shock synchrotron spectrum peaks in the optical at about 10 ks. The latter has two consequences: the wind must be very tenuous and the optical emission before 10 ks must arise from the reverse-shock, as suggested also by the bright optical flash that Raptor has monitored during the prompt emission phase (<100 s). The VLA radio emission is from the reverse-shock, the Swift X-ray emission is mostly from the forward-shock, but the both shocks give comparable contributions to the Fermi GeV emission. The weak wind implies a large blast-wave radius (8 t_{day}^{1/2} pc), which requires a very tenuous c...

  2. Fireballs and cannonballs confront the afterglow of GRB 991208

    CERN Document Server

    Dado, S; De Rújula, Alvaro; Dado, Shlomo; Dar, Arnon; Rujula, Alvaro De

    2003-01-01

    Galama et al. have recently reported their follow-up measurements of the radio afterglow (AG) of the Gamma Ray Burst (GRB) 991208, up to 293 days after burst, and their reanalysis of the broad-band AG, in the framework of standard fireball models. They advocate a serious revision of their prior analysis and conclusions, based on optical data and on their earlier observations during the first two weeks of the AG. We comment on their work and fill a lacuna: these authors have overlooked the possibility of comparing their new data to the available predictions of the cannonball (CB) model, based --like their incorrect predictions-- on the first round of data. The new data are in good agreement with these CB-model predictions. This is in spite of the fact that, in comparison to the fireball models, the CB model is much simpler, much more predictive, has many fewer parameters, practically no free choices... and it describes well --on a universal basis-- all the measured AGs of GRBs of known redshift.

  3. LAGOVirtual: A Collaborative Environment for the Large Aperture GRB Observatory

    CERN Document Server

    Camacho, R; Diaz, G; Guada, C; Hamar, V; Hoeger, H; Melfo, A; Nunez, L A; Perez, Y; Quintero, C; Rosales, M; Torrens, R

    2009-01-01

    We present the LAGOVirtual Project: an ongoing project to develop platform to collaborate in the Large Aperture GRB Observatory (LAGO). This continental-wide observatory is devised to detect high energy (around 100 GeV) component of Gamma Ray Bursts, by using the single particle technique in arrays of Water Cherenkov Detectors (WCD) at high mountain sites (Chacaltaya, Bolivia, 5300 m a.s.l., Pico Espejo, Venezuela, 4750 m a.s.l., Sierra Negra, Mexico, 4650 m a.s.l). This platform will allow LAGO collaboration to share data, and computer resources through its different sites. This environment has the possibility to generate synthetic data by simulating the showers through AIRES application and to store/preserve distributed data files collected by the WCD at the LAGO sites. The present article concerns the implementation of a prototype of LAGO-DR adapting DSpace, with a hierarchical structure (i.e. country, institution, followed by collections that contain the metadata and data files), for the captured/simulate...

  4. The emission mechanism in magnetically dominated GRB outflows

    CERN Document Server

    Beniamini, Paz

    2014-01-01

    We consider the conditions within Gamma-Ray Burst (GRB) emission region that is Poynting flux dominated. Due to the enormous magnetic energy density, relativistic electrons will cool in such a region extremely rapidly via synchrotron. As there is no known mechanism that can compete with synchrotron it must be the source of the prompt sub-MeV emission. This sets strong limits on the size and Lorentz factor of the outflow. Furthermore, synchrotron cooling is too efficient. It overproduces optical and X-ray as compared with the observations. This overproduction of low energy emission can be avoided if the electrons are re-accelerated many times ($\\gtrsim 5\\times 10^4$) during each pulse (or are continuously heated) or if they escape the emitting region before cooling down. We explore the limitations of both models, practically ruling out the later and demonstrating that the former requires two different acceleration mechanisms as well as an extremely large magnetic energy to Baryonic energy ratio. To be viable, ...

  5. Modeling the early multiwavelength emission in GRB130427A

    CERN Document Server

    Fraija, Nissim; Veres, Péter

    2016-01-01

    One of the most powerful gamma-ray bursts, GRB 130427A was swiftly detected from GeV $\\gamma$-rays to optical wavelengths. In the GeV band, the Large Area Telescope (LAT) on board the Fermi Gamma-Ray Space Telescope observed the highest-energy photon ever recorded of 95 GeV, and a bright peak in the early phase followed by emission temporally extended for more than 20 hours. In the optical band, a bright flash with a magnitude of $7.03\\pm 0.03$ in the time interval from 9.31 s to 19.31 s after the trigger was reported by RAPTOR in r-band. We study the origin of the GeV $\\gamma$-ray emission, using the multiwavelength observation detected in X-ray and optical bands. The origin of the temporally extended LAT, X-ray and optical flux is naturally interpreted as synchrotron radiation and the 95-GeV photon and the integral flux upper limits placed by the HAWC observatory are consistent with synchrotron self-Compton from an adiabatic forward shock propagating into the stellar wind of its progenitor. The extreme LAT ...

  6. MODELING THE EARLY MULTIWAVELENGTH EMISSION IN GRB 130427A

    Energy Technology Data Exchange (ETDEWEB)

    Fraija, N.; Lee, W. [Instituto de Astronomía, Universidad Nacional Autónoma de México, Apdo. Postal 70-264, Cd. Universitaria, DF 04510, México (Mexico); Veres, P., E-mail: nifraija@astro.unam.mx, E-mail: wlee@astro.unam.mx, E-mail: pv0004@uah.edu [Center for Space Plasma and Aeronomic Research (CSPAR), University of Alabama in Huntsville, Huntsville, AL 35899 (United States)

    2016-02-20

    One of the most powerful gamma-ray bursts, GRB 130427A was swiftly detected from GeV γ-rays to optical wavelengths. In the GeV band, the Large Area Telescope (LAT) on board the Fermi Gamma-Ray Space Telescope observed the highest-energy photon ever recorded of 95 GeV and a bright peak in the early phase followed by emission temporally extended for more than 20 hr. In the optical band, a bright flash with a magnitude of 7.03 ± 0.03 in the time interval from 9.31 to 19.31 s after the trigger was reported by RAPTOR in r band. We study the origin of the GeV γ-ray emission, using the multiwavelength observation detected in X-ray and optical bands. The origin of the temporally extended LAT, X-ray, and optical flux is naturally interpreted as synchrotron radiation, and the 95 GeV photon and the integral flux upper limits placed by the high-altitude water Cerenkov observatory are consistent with synchrotron self-Compton from an adiabatic forward shock propagating into the stellar wind of its progenitor. The extreme LAT peak and the bright optical flash are explained through synchrotron self-Compton and synchrotron emission from the reverse shock, respectively, when the ejecta evolves in the thick-shell regime and carries a significant magnetic field.

  7. Swift captures the spectrally evolving prompt emission of GRB 070616

    CERN Document Server

    Starling, R L C; Willingale, R; Page, K L; Osborne, J P; De Pasquale, M; Nakagawa, Y E; Kuin, N P M; Onda, K; Norris, J P; Ukwatta, T N; Kodaka, N; Burrows, D N; Kennea, J A; Page, M J; Perri, M; Markwardt, C B

    2007-01-01

    The origins of Gamma-ray Burst prompt emission are currently not well understood and in this context long, well-observed events are particularly important to study. We present the case of GRB 070616, analysing the exceptionally long-duration multipeaked prompt emission, and later afterglow, captured by all the instruments on-board Swift and by Suzaku WAM. The high energy light curve remained generally flat for several hundred seconds before going into a steep decline. Spectral evolution from hard to soft is clearly taking place throughout the prompt emission, beginning at 285 s after the trigger and extending to 1200 s. We track the movement of the spectral peak energy, whilst observing a softening of the low energy spectral slope. The steep decline in flux may be caused by a combination of this strong spectral evolution and the curvature effect. We investigate origins for the spectral evolution, ruling out a superposition of two power laws and considering instead an additional component dominant during the l...

  8. Are GRB Blackbodies an Artifact of Spectral Evolution?

    CERN Document Server

    Burgess, J Michael

    2014-01-01

    The analysis of gamma-ray burst (GRB) spectra with multi-component emission models has become an important part of the field. In particular, multi-component analysis where one component is a blackbody representing emission from a photosphere has enabled both a more detailed understanding of the energy content of the jet as well as the ability to examine the dynamic structure of the outflow. While the existence of a blackbody-like component has been shown to be significant and not a byproduct of background fluctuations, it is very possible that it can be an artifact of spectral evolution of a single component that is being poorly resolved in time. Herein, this possibility is tested by simulating a single component evolving in time and then folding the spectra through the $Fermi$ detector response to generate time-tagged event Gamma-ray Burst Monitor (GBM) data. We then fit both the time integrated and resolved generated spectral data with a multi-component model using standard tools. It is found that in {\\it t...

  9. AstroSat CZT Imager observations of GRB 151006A: timing, spectroscopy, and polarisation study

    CERN Document Server

    Rao, A R; Hingar, M K; Iyyani, S; Khanna, Rakesh; Kutty, A P K; Malkar, J P; Paul, D; Bhalerao, V B; Bhattacharya, D; Dewangan, G C; Pawar, Pramod; Vibhute, A M; Chattopadhyay, T; Mithun, N P S; Vadawale, S V; Vagshette, N; Basak, R; Pradeep, P; Samuel, Essy; Sreekumar, S; Vinod, P; Navalgund, K H; Pandiyan, R; Sarma, K S; Seetha, S; Subbarao, K

    2016-01-01

    AstroSat is a multi-wavelength satellite launched on 2015 September 28. The CZT Imager of AstroSat on its very first day of operation detected a long duration gamma-ray burst (GRB) namely GRB 151006A. Using the off-axis imaging and spectral response of the instrument, we demonstrate that CZT Imager can localise this GRB correct to about a few degrees and it can provide, in conjunction with Swift, spectral parameters similar to that obtained from Fermi/GBM. Hence CZT Imager would be a useful addition to the currently operating GRB instruments (Swift and Fermi). Specifically, we argue that the CZT Imager will be most useful for the short hard GRBs by providing localisation for those detected by Fermi and spectral information for those detected only by Swift. We also provide preliminary results on a new exciting capability of this instrument: CZT Imager is able to identify Compton scattered events thereby providing polarisation information for bright GRBs. GRB 151006A, in spite of being relatively faint, shows h...

  10. On the Host Galaxy of GRB 150101B and the Associated Active Galactic Nucleus

    CERN Document Server

    Xie, Chen; Wang, Junfeng; Liu, Tong; Jiang, Xiaochuan

    2016-01-01

    We present a multi-wavelength analysis of the host galaxy of short-duration gamma-ray burst (GRB) 150101B. Follow-up optical and X-ray observations suggested that the host galaxy, 2MASX J12320498-1056010, likely harbors a low-luminosity active galactic nuclei (AGN). Our modeling of the spectral energy distribution (SED) has confirmed the nature of the AGN, making it the first reported GRB host that contains an AGN. We have also found the host galaxy is a massive elliptical galaxy with stellar population of $\\sim 5.7\\ Gyr$, one of the oldest among the short-duration GRB hosts. Our analysis suggests that the host galaxy can be classified as an X-ray bright, optically normal galaxy (XBONG), and the central AGN is likely dominated by a radiatively inefficient accretion flow (RIAF). Our work explores interesting connection that may exist between GRB and AGN activities of the host galaxy, which can help understand the host environment of the GRB events and the roles of AGN feedback.

  11. GRB 110715A: the peculiar multiwavelength evolution of the first afterglow detected by ALMA

    Science.gov (United States)

    Sánchez-Ramírez, R.; Hancock, P. J.; Jóhannesson, G.; Murphy, Tara; de Ugarte Postigo, A.; Gorosabel, J.; Kann, D. A.; Krühler, T.; Oates, S. R.; Japelj, J.; Thöne, C. C.; Lundgren, A.; Perley, D. A.; Malesani, D.; de Gregorio Monsalvo, I.; Castro-Tirado, A. J.; D'Elia, V.; Fynbo, J. P. U.; Garcia-Appadoo, D.; Goldoni, P.; Greiner, J.; Hu, Y.-D.; Jelínek, M.; Jeong, S.; Kamble, A.; Klose, S.; Kuin, N. P. M.; Llorente, A.; Martín, S.; Nicuesa Guelbenzu, A.; Rossi, A.; Schady, P.; Sparre, M.; Sudilovsky, V.; Tello, J. C.; Updike, A.; Wiersema, K.; Zhang, B.-B.

    2017-02-01

    We present the extensive follow-up campaign on the afterglow of GRB 110715A at 17 different wavelengths, from X-ray to radio bands, starting 81 s after the burst and extending up to 74 d later. We performed for the first time a GRB afterglow observation with the ALMA observatory. We find that the afterglow of GRB 110715A is very bright at optical and radio wavelengths. We use the optical and near-infrared spectroscopy to provide further information about the progenitor's environment and its host galaxy. The spectrum shows weak absorption features at a redshift z = 0.8225, which reveal a host-galaxy environment with low ionization, column density, and dynamical activity. Late deep imaging shows a very faint galaxy, consistent with the spectroscopic results. The broad-band afterglow emission is modelled with synchrotron radiation using a numerical algorithm and we determine the best-fitting parameters using Bayesian inference in order to constrain the physical parameters of the jet and the medium in which the relativistic shock propagates. We fitted our data with a variety of models, including different density profiles and energy injections. Although the general behaviour can be roughly described by these models, none of them are able to fully explain all data points simultaneously. GRB 110715A shows the complexity of reproducing extensive multiwavelength broad-band afterglow observations, and the need of good sampling in wavelength and time and more complex models to accurately constrain the physics of GRB afterglows.

  12. Constraining the GRB-magnetar model by means of the Galactic pulsar population

    CERN Document Server

    Rea, Nanda; Pons, Jose' A; Perna, Rosalba; Dainotti, Maria G; Miralles, Juan A; Torres, Diego F

    2015-01-01

    A large fraction of Gamma Ray Bursts (GRBs) displays an X-ray plateau phase within <10^{5} s from the prompt emission, proposed to be powered by the spin-down energy of a rapidly spinning newly born magnetar. In this work we use the properties of the Galactic neutron star population to constrain the GRB-magnetar scenario. We re-analyze the X-ray plateaus of all Swift GRBs with known redshift, between January 2005 and August 2014. From the derived initial magnetic field distribution for the possible magnetars left behind by the GRBs, we study the evolution and properties of a simulated GRB-magnetar population using numerical simulations of magnetic field evolution, coupled with Monte Carlo simulations of Pulsar Population Synthesis in our Galaxy. We find that if the GRB X-ray plateaus are powered by the rotational energy of a newly formed magnetar, the current observational properties of the Galactic magnetar population are not compatible with being formed within the GRB scenario (regardless of the GRB type...

  13. HAPPY BIRTHDAY SWIFT: ULTRA-LONG GRB 141121A AND ITS BROADBAND AFTERGLOW

    Energy Technology Data Exchange (ETDEWEB)

    Cucchiara, A. [Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Veres, P. [The George Washington University, Department of Physics, 725 21st, NW Washington, DC 20052 (United States); Corsi, A. [Physics Department, Texas Tech University, Box 41051, Lubbock, TX 79409 (United States); Cenko, S. B.; Marshall, F. E.; Kutyrev, A. S. [Astrophysics Science Division, NASA Goddard Space Flight Center, MC 661, Greenbelt, MD 20771 (United States); Perley, D. A.; Horesh, A. [Department of Astronomy, California Institute of Technology, MC 249-17, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Lien, A. [Center for Research and Exploration in Space Science and Technology (CRESST) and NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Pagani, C. [Department of Physics and Astronomy, University of Leicester, University Road, Leicester LE1 7RH (United Kingdom); Toy, V. L.; Capone, J. I. [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Frail, D. A. [National Radio Astronomy Observatory P.O. Box 0. Socorro, NM (United States); Modjaz, M. [Center for Cosmology and Particle Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); Butler, N. R.; Littlejohns, O. M. [School of Earth and Space Exploration, Arizona State University, AZ 85287 (United States); Watson, A. M.; Lee, W. H.; Richer, M. G. [Instituto de Astronomía, Universidad Nacional Autónoma de México, Apartado Postal 70-264, 04510 México, D. F., México (Mexico); Klein, C. R., E-mail: antonino.cucchiara@nasa.gov [Astronomy Department, University of California, Berkeley, CA 94720-7450 (United States); and others

    2015-10-20

    We present our extensive observational campaign on the Swift-discovered GRB 141121A, almost 10 years after its launch. Our observations cover radio through X-rays and extend for more than 30 days after discovery. The prompt phase of GRB 141121A lasted 1410 s and, at the derived redshift of z = 1.469, the isotropic energy is E{sub γ,iso} = 8.0 × 10{sup 52} erg. Due to the long prompt duration, GRB 141121A falls into the recently discovered class of ultra-long GRBs (UL-GRBs). Peculiar features of this burst are (1) a flat early-time optical light curve and (2) a radio-to-X-ray rebrightening around three days after the burst. The latter is followed by a steep optical-to-X-ray decay and a much shallower radio fading. We analyze GRB 141121A in the context of the standard forward–reverse shock (FS, RS) scenario and we disentangle the FS and RS contributions. Finally, we comment on the puzzling early-time (t ≲ 3 days) behavior of GRB 141121A, and suggest that its interpretation may require a two-component jet model. Overall, our analysis confirms that the class of UL-GRBs represents our best opportunity to firmly establish the prominent emission mechanisms in action during powerful gamma-ray burst explosions, and future missions (like SVOM, XTiDE, or ISS-Lobster) will provide many more of such objects.

  14. The ECLAIRs GRB-trigger telescope on-board the future mission SVOM

    CERN Document Server

    Schanne, Stéphane; Atteia, Jean-Luc; Godet, Olivier; Lachaud, Cyril; Mercier, Karine

    2015-01-01

    The Space-based multi-band astronomical Variable Objects Monitor (SVOM) is an approved satellite mission for Gamma-Ray Burst (GRB) studies, developed in cooperation between the Chinese National Space Agency (CNSA), the Chinese Academy of Sciences (CAS), the French Space Agency (CNES) and French laboratories. SVOM entered Phase B in 2014 and is scheduled for launch in 2021. SVOM will provide fast and accurate GRB localizations, and determine the temporal and spectral properties of the GRB emission, thanks to a set of 4 on-board instruments. The trigger system of the coded-mask telescope ECLAIRs images the sky in the 4-120 keV energy range, in order to detect and localize GRBs in its 2 sr-wide field of view. The low-energy threshold of ECLAIRs is well suited for the detection of highly redshifted GRB. The high-energy coverage is extended up to 5 MeV thanks to the non-imaging gamma-ray spectrometer GRM. GRB alerts are sent in real-time to the ground observers community, and a spacecraft slew is performed in orde...

  15. GRB 070125 and the environments of spectral-line poor afterglow absorbers

    CERN Document Server

    De Cia, A; Wiersema, K; van der Horst, A J; Vreeswijk, P M; Björnsson, G; Postigo, A de Ugarte; Jakobsson, P; Levan, A J; Rol, E; Schulze, S; Tanvir, N R

    2011-01-01

    GRB 070125 is among the most energetic bursts detected and the most extensively observed so far. Nevertheless, unresolved issues are still open in the literature on the physics of the afterglow and on the GRB environment. In particular, GRB 070125 was claimed to have exploded in a galactic halo environment, based on the uniqueness of the optical spectrum and the non-detection of an underlying host galaxy. In this work we collect all publicly available data and address these issues by modelling the NIR-to-X-ray spectral energy distribution (SED) and studying the high signal-to-noise VLT/FORS afterglow spectrum in comparison with a larger sample of GRB absorbers. The SED reveals a synchrotron cooling break in the UV, low equivalent hydrogen column density and little reddening caused by a LMC- or SMC-type extinction curve. From the weak MgII absorption at z=1.5477 in the spectrum, we derived logN(MgII)=12.96+0.13-0.18 and upper limits on the ionic column density of several metals. These suggest that the GRB abso...

  16. On the mass-metallicity relation, velocity dispersion and gravitational well depth of GRB host galaxies

    CERN Document Server

    Arabsalmani, Maryam; Fynbo, Johan P U; Christensen, Lise; Freudling, Wolfram; Savaglio, Sandra; Zafar, Tayyaba

    2014-01-01

    We analyze a sample of 16 absorption systems intrinsic to long duration GRB host galaxies at $z \\gtrsim 2$ for which the metallicities are known. We compare the relation between the metallicity and cold gas velocity width for this sample to that of the QSO-DLAs, and find complete agreement. We then compare the redshift evolution of the mass-metallicity relation of our sample to that of QSO-DLAs and find that also GRB hosts favour a late onset of this evolution, around a redshift of $\\approx 2.6$. We compute predicted stellar masses for the GRB host galaxies using the prescription determined from QSO-DLA samples and compare the measured stellar masses for the four hosts where stellar masses have been determined from SED fits. We find excellent agreement and conclude that, on basis of all available data and tests, long duration GRB-DLA hosts and intervening QSO-DLAs are consistent with being drawn from the same underlying population. GRB host galaxies and QSO-DLAs are found to have different impact parameter di...

  17. Revealing Physical Activity of GRB Central Engine with Macronova/Kilonova Data

    Science.gov (United States)

    Shen, Zhao-Qiang; Jin, Zhi-Ping; Liang, Yun-Feng; Li, Xiang; Fan, Yi-Zhong; Wei, Da-Ming

    2017-02-01

    The modeling of Li-Paczyński macronova/kilonova signals gives a reasonable estimate on the neutron-rich material ejected during the neutron star mergers. Usually the accretion disk is more massive than the macronova ejecta, with which the efficiencies of converting the disk mass into prompt emission of three merger-driven GRBs can hence be directly constrained. Supposing the macronovae/kilonovae associated with GRB 050709, GRB 060614, and GRB 130603B arose from radioactive decay of the r-process material, the upper limit on energy conversion efficiencies are found to be as low as ∼10‑6–10‑4. Moreover, for all three events, neutrino annihilation is likely powerful enough to account for the brief gamma-ray flashes. Neutrino annihilation can also explain the “extended” emission lasting ∼100 s in GRB 050709, but does not work for the one in GRB 060614. These progresses demonstrate that the macronova can serve as a novel probe of the central engine activity.

  18. Happy Birthday Swift: Ultra-long GRB141121A and its broad-band Afterglow

    CERN Document Server

    Cucchiara, A; Corsi, A; Cenko, S B; Perley, D A; Marshall, A Lien F E; Pagani, C; Toy, V L; Capone, J I; Frail, D A; Horesh, A; Modjaz, M; Butler, N R; Littlejohns, O M; Watson, A M; Kutyrev, A S; Lee, W H; Richer, M G; Klein, C R; Fox, O D; Prochaska, J X; Bloom, J S; Troja, E; Ramirez-Ruiz, E; de Diego, J A; Georgiev, L; Gonzalez, J; Roman-Zuniga, C G; Gehrels, N; Moseley, H

    2015-01-01

    We present our extensive observational campaign on the Swift-discovered GRB141121A, al- most ten years after its launch. Our observations covers radio through X-rays, and extends for more than 30 days after discovery. The prompt phase of GRB 141121A lasted 1410 s and, at the derived redshift of z = 1.469, the isotropic energy is E{\\gamma},iso = 8.0x10^52 erg. Due to the long prompt duration, GRB141121A falls into the recently discovered class of UL-GRBs. Peculiar features of this burst are a flat early-time optical light curve and a radio-to-X-ray rebrightening around 3 days after the burst. The latter is followed by a steep optical-to-X-ray decay and a much shallower radio fading. We analyze GRB 141121A in the context of the standard forward-reverse shock (FS,RS) scenario and we disentangle the FS and RS contributions. Finally, we comment on the puzzling early-time (t ~3 d) behavior of GRB 141121A, and suggest that its interpretation may require a two-component jet model. Overall, our analysis confirms that ...

  19. GRB 130606A within a sub-DLA at redshift 5.91

    CERN Document Server

    Castro-Tirado, A J; Ellison, S L; Jelínek, M; Martín-Carrillo, A; Bromm, V; Gorosabel, J; Bremer, M; Winters, J M; Hanlon, L; Meegan, S; Topinka, M; Pandey, S B; Guziy, S; Jeong, S; Sonbas, E; Pozanenko, A S; Cunniffe, R; Fernández-Muñoz, R; Ferrero, P; Gehrels, N; Hudec, R; Kubánek, P; Lara-Gil, O; Muñoz-Martínez, V F; Pérez-Ramírez, D; Štrobl, J; Álvarez-Iglesias, C; Inasaridze, R; Rumyantsev, V; Volnova, A; Hellmich, S; Mottola, S; Cerón, J M Castro; Cepa, J; Göğüş, E; Güver, T; Taş, Ö Önal; Park, I H; Sabau-Graziati, L; Tejero, A

    2013-01-01

    Events such as GRB130606A at z=5.91, offer an exciting new window into pre-galactic metal enrichment in these very high redshift host galaxies. We study the environment and host galaxy of GRB 130606A, a high-z event, in the context of a high redshift population of GRBs. We have obtained multiwavelength observations from radio to gamma-ray, concentrating particularly on the X-ray evolution as well as the optical photometric and spectroscopic data analysis. With an initial Lorentz bulk factor in the range \\Gamma_0 ~ 65-220, the X-ray afterglow evolution can be explained by a time-dependent photoionization of the local circumburst medium, within a compact and dense environment. The host galaxy is a sub-DLA (log N (HI) = 19.85+/-0.15), with a metallicity content in the range from ~1/7 to ~1/60 of solar. Highly ionized species (N V and Si IV) are also detected. This is the second highest redshift burst with a measured GRB-DLA metallicity and only the third GRB absorber with sub-DLA HI column density. GRB ' lightho...

  20. Late time observations of GRB080319B: jet break, host galaxy and accompanying supernova

    CERN Document Server

    Tanvir, Nial R; Levan, Andrew; Fruchter, Andrew; Granot, Jonathan; Svensson, Karl M; O'Brien, Paul T; Wiersema, Klaas; Starling, Rhaana L C; Jakobsson, Pall; Fynbo, Johan; Hjorth, Jens; Curran, Peter; van der Horst, Alexander J; Kouveliotou, Chryssa; Racusin, Judith L; Burrows, David N; Genet, Frank

    2008-01-01

    The Swift-discovered GRB080319B was by far the most distant source ever observed at naked eye brightness, reaching a peak magnitude of 5.3 at a redshift of z=0.937. We present our late time optical and X-ray observations, which confirm that an achromatic break occurred in the power-law afterglow light curve at ~10^6 s post-burst. This most likely indicates that the gamma-ray burst (GRB) outflow was collimated, which for a uniform jet would imply a total energy in the jet E_{jet} \\gsim 10^{52.5} erg. Our observations also show a late-time excess of red light, which is well explained if the GRB was accompanied by a supernova, similar to those seen in some other long-duration GRBs. The latest observations are dominated by light from the host and show that the GRB took place in a faint dwarf galaxy (r(AB) = 27.2, rest-frame M_B = -17.3). This galaxy is small even by the standards of other GRB hosts, which is suggestive of a low metallicity environment.

  1. HST Data Suggest Proper Motion for the Optical Counterpart of GRB 970228

    CERN Document Server

    Caraveo, P A; Tavani, M; Bignami, Giovanni Fabrizio

    1997-01-01

    After a quarter of a century of gamma-ray burst (GRB) astronomy, the Italian-Dutch satellite BeppoSAX on Feb 28th, 1997 detected a soft X-ray afterglow from GRB 970228 and positioned it accurately. This made possible the successful detection of an optical transient. Two public Hubble Space Telescope (HST) images of the GRB/optical transient region were taken on March 26th and April 7th, 1997. They are analyzed here, with the purpose of understanding the nature of GRB 970228. We find that the position of the faint point-like object V ~ 26 seen at the transient location changed by 0.40 +/-0.10 pixels in 12 days, corresponding to a proper motion of ~ 550 mas/year. By comparison, four adjacent sources in the same field do not show any significant displacement, with astrometric residuals close to zero and average absolute displacements less than 0.09 pixels. If confirmed, this result would strongly support the galactic nature of GRB 970228.

  2. Super-solar metallicity at the position of the ultra-long GRB130925A

    CERN Document Server

    Schady, P; Greiner, J; Graham, J F; Kann, D A; Bolmer, J; Delvaux, C; Elliott, J; Klose, S; Knust, F; Guelbenzu, A Nicuesa; Rau, A; Rossi, A; Savaglio, S; Schmidl, S; Sudilovsky, T Schweyer V; Tanga, M; Tanvir, N R; Varela, K; Wiseman, P

    2015-01-01

    Over the last decade there has been immense progress in the follow-up of short and long GRBs, resulting in a significant rise in the detection rate of X-ray and optical afterglows, in the determination of GRB redshifts, and of the identification of the underlying host galaxies. Nevertheless, our theoretical understanding on the progenitors and central engines powering these vast explosions is lagging behind, and a newly identified class of `ultra-long' GRBs has fuelled speculation on the existence of a new channel of GRB formation. In this paper we present high signal-to-noise X-shooter observations of the host galaxy of GRB130925A, which is the fourth unambiguously identified ultra-long GRB, with prompt gamma-ray emission detected for ~20ks. The GRB line of sight was close to the host galaxy nucleus, and our spectroscopic observations cover both this region along the bulge/disk of the galaxy, in addition to a bright star-forming region within the outskirts of the galaxy. From our broad wavelength coverage we...

  3. Synchrotron radiation and diffusive shock acceleration - A short review and GRB perspective

    Energy Technology Data Exchange (ETDEWEB)

    Karlica, Mile, E-mail: mile.karlica@icranet.org [La Sapienza University of Rome - ICRANet, Piazzale Aldo Moro 5, 00189 Rome (Italy)

    2015-12-17

    In this talk we present the sponge” model and its possible implications on the GRB afterglow light curves. “Sponge” model describes source of GRB afterglow radiation as fragmented GRB ejecta where bubbles move through the rarefied medium. In the first part of the talk a short introduction to synchrotron radiation and Fermi acceleration was presented. In the assumption that X-ray luminosity of GRB afterglow phase comes from the kinetic energy losses of clouds in ejecta medium radiated as synchrotron radiation we solved currently very simple equation of motion to find which combination of cloud and medium regime describes the afterglow light curve the best. We proposed for the first step to watch simple combinations of expansion regimes for both bubbles and surrounding medium. The closest case to the numerical fit of GRB 150403A with time power law index k = 1.38 is the combination of constant bubbles and Sedov like expanding medium with time power law index k = 1.25. Of course the question of possible mixture of variuos regime combinations is still open within this model.

  4. GRB 140206A: the most distant polarized Gamma-Ray Burst

    CERN Document Server

    Gotz, D; Antier, S; Covino, S; D'Avanzo, P; D'Elia, V; Melandri, A

    2014-01-01

    The nature of the prompt gamma-ray emission of Gamma-Ray Bursts (GRBs) is still far from being completely elucidated. The measure of linear polarization is a powerful tool that can be used to put further constraints on the content and magnetization of the GRB relativistic outflows, as well as on the radiation processes at work. To date only a handful of polarization measurements are available for the prompt emission of GRBs. Here we present the analysis of the prompt emission of GRB 140206A, obtained with INTEGRAL/IBIS, Swift/BAT, and Fermi/GBM. Using INTEGRAL/IBIS as a Compton polarimeter we were able to constrain the linear polarization level of the second peak of this GRB as being larger than 28% at 90% c.l. We also present the GRB afterglow optical spectroscopy obtained at the Telescopio Nazionale Galileo (TNG), which allowed us the measure the distance of this GRB, z=2.739. This distance value together with the polarization measure obtained with IBIS, allowed us to derive the deepest and most reliable li...

  5. "Dark" GRB 080325 In A Dusty Massive Galaxy At z \\sim 2

    CERN Document Server

    Hashimoto, T; Aoki, K; Tanaka, I; Yabe, K; Kawai, N; Aoki, W; Furusawa, H; Hattori, T; Iye, M; Kawabata, K S; Kobayashi, N; Komiyama, Y; Kosugi, G; Minowa, Y; Mizumoto, Y; Niino, Y; Nomoto, K; Noumaru, J; Ogasawara, R; Pyo, T -S; Sakamoto, T; Sekiguchi, K; Shirasaki, Y; Suzuki, M; Tajitsu, A; Takata, T; Tamagawa, T; Terada, H; Totani, T; Watanabe, J; Yamada, T; Yoshida, A

    2010-01-01

    We present optical and near infrared observations of GRB 080325 putatively classified as a "Dark GRB". Near-infrared observations with Subaru/MOIRCS provided a clear detection of afterglow in Ks band, although no optical counterpart was reported. The flux ratio of rest-wavelength optical to X-ray bands of the afterglow indicates that the dust extinction along the line of sight to the afterglow is Av = 2.5 - 10 mag. This large extinction is probably the major reason for optical faintness of GRB 080325. The J - Ks color of the host galaxy, (J - Ks = 1.3 in AB magnitude), is significantly redder than those for typical GRB hosts previously identified. In addition to J and Ks bands, optical images in B, Rc, i', and z' bands with Subaru/Suprime-Cam were obtained at about one year after the burst, and a photometric redshift of the host is estimated to be z_{photo} = 1.9. The host luminosity is comparable to L^{*} at z \\sim 2 in contrast to the sub-L^{*} property of typical GRB hosts at lower redshifts. The best-fit ...

  6. Cognitive Style as Environmentally Sensitive Individual Differences in Cognition: A Modern Synthesis and Applications in Education, Business, and Management.

    Science.gov (United States)

    Kozhevnikov, Maria; Evans, Carol; Kosslyn, Stephen M

    2014-05-01

    The key aims of this article are to relate the construct of cognitive style to current theories in cognitive psychology and neuroscience and to outline a framework that integrates the findings on individual differences in cognition across different disciplines. First, we characterize cognitive style as patterns of adaptation to the external world that develop on the basis of innate predispositions, the interactions among which are shaped by changing environmental demands. Second, we show that research on cognitive style in psychology and cross-cultural neuroscience, on learning styles in education, and on decision-making styles in business and management all address the same phenomena. Third, we review cognitive-psychology and neuroscience research that supports the validity of the concept of cognitive style. Fourth, we show that various styles from disparate disciplines can be organized into a single taxonomy. This taxonomy allows us to integrate all the well-documented cognitive, learning, and decision-making styles; all of these style types correspond to adaptive systems that draw on different levels of information processing. Finally, we discuss how the proposed approach might promote greater coherence in research and application in education, in business and management, and in other disciplines.

  7. NuSTARobservations of grb 130427a establish a single component synchrotron afterglow origin for the late optical to multi-gev emission

    DEFF Research Database (Denmark)

    Kouveliotou, C.; Granot, J.; Racusin, J. L.

    2013-01-01

    GRB 130427A occurred in a relatively nearby galaxy; its prompt emission had the largest GRB fluence ever recorded. The afterglow of GRB 130427A was bright enough for the Nuclear Spectroscopic Telescope ARray (NuSTAR) to observe it in the 3-79 keV energy range long after its prompt emission (simil...

  8. The Long Term Role of Anxiety Sensitivity and Experiential Avoidance on Pain Intensity, Mood, and Disability among Individuals in a Specialist Pain Clinic

    Directory of Open Access Journals (Sweden)

    S. Mehta

    2016-01-01

    Full Text Available Background. Anxiety sensitivity (AS and experiential avoidance (EA have been shown to have an interactive effect on the response an individual has to chronic pain (CP potentially resulting in long term negative outcomes. Objective. The current study attempted to (1 identify distinct CP subgroups based on their level of EA and AS and (2 compare the subgroups in terms of mood and disability. Methods. Individuals with CP were recruited from an academic pain clinic. Individuals were assessed for demographic, psychosocial, and personality measures at baseline and 1-year follow-up. A cluster analysis was conducted to identify distinct subgroups of patients based on their level of EA and AS. Differences in clinical outcomes were compared using the Repeated Measures MANOVA. Results. From a total of 229 participants, five clusters were formed. Subgroups with lower levels of AS but similar high levels of EA did not differ in outcomes. Mood impairment was significantly greater among those with high levels of EA compared to lower levels (p<0.05. Significant improvement in disability (p<0.05 was only seen among those with lower levels of EA and AS. Conclusions. This cluster analysis demonstrated that EA had a greater influence on mood impairment, while both EA and AS levels affected disability outcomes among individuals with CP.

  9. The Long Term Role of Anxiety Sensitivity and Experiential Avoidance on Pain Intensity, Mood, and Disability among Individuals in a Specialist Pain Clinic.

    Science.gov (United States)

    Mehta, S; Rice, D; Janzen, S; Serrato, J; Getty, H; Shapiro, A P; Morley-Forster, P; Sequeira, K; Teasell, R W

    2016-01-01

    Background. Anxiety sensitivity (AS) and experiential avoidance (EA) have been shown to have an interactive effect on the response an individual has to chronic pain (CP) potentially resulting in long term negative outcomes. Objective. The current study attempted to (1) identify distinct CP subgroups based on their level of EA and AS and (2) compare the subgroups in terms of mood and disability. Methods. Individuals with CP were recruited from an academic pain clinic. Individuals were assessed for demographic, psychosocial, and personality measures at baseline and 1-year follow-up. A cluster analysis was conducted to identify distinct subgroups of patients based on their level of EA and AS. Differences in clinical outcomes were compared using the Repeated Measures MANOVA. Results. From a total of 229 participants, five clusters were formed. Subgroups with lower levels of AS but similar high levels of EA did not differ in outcomes. Mood impairment was significantly greater among those with high levels of EA compared to lower levels (p < 0.05). Significant improvement in disability (p < 0.05) was only seen among those with lower levels of EA and AS. Conclusions. This cluster analysis demonstrated that EA had a greater influence on mood impairment, while both EA and AS levels affected disability outcomes among individuals with CP.

  10. A New ELISA Using the ANANAS Technology Showing High Sensitivity to diagnose the Bovine Rhinotracheitis from Individual Sera to Pooled Milk.

    Science.gov (United States)

    Casarin, Elisabetta; Lucchese, Laura; Grazioli, Santina; Facchin, Sonia; Realdon, Nicola; Brocchi, Emiliana; Morpurgo, Margherita; Nardelli, Stefano

    2016-01-01

    Diagnostic tests for veterinary surveillance programs should be efficient, easy to use and, possibly, economical. In this context, classic Enzyme linked ImmunoSorbent Assay (ELISA) remains the most common analytical platform employed for serological analyses. The analysis of pooled samples instead of individual ones is a common procedure that permits to certify, with one single test, entire herds as "disease-free". However, diagnostic tests for pooled samples need to be particularly sensitive, especially when the levels of disease markers are low, as in the case of anti-BoHV1 antibodies in milk as markers of Infectious Bovine Rhinotracheitis (IBR) disease. The avidin-nucleic-acid-nanoassembly (ANANAS) is a novel kind of signal amplification platform for immunodiagnostics based on colloidal poly-avidin nanoparticles that, using model analytes, was shown to strongly increase ELISA test performance as compared to monomeric avidin. Here, for the first time, we applied the ANANAS reagent integration in a real diagnostic context. The monoclonal 1G10 anti-bovine IgG1 antibody was biotinylated and integrated with the ANANAS reagents for indirect IBR diagnosis from pooled milk mimicking tank samples from herds with IBR prevalence between 1 to 8%. The sensitivity and specificity of the ANANAS integrated method was compared to that of a classic test based on the same 1G10 antibody directly linked to horseradish peroxidase, and a commercial IDEXX kit recently introduced in the market. ANANAS integration increased by 5-fold the sensitivity of the 1G10 mAb-based conventional ELISA without loosing specificity. When compared to the commercial kit, the 1G10-ANANAS integrated method was capable to detect the presence of anti-BHV1 antibodies from bulk milk of gE antibody positive animals with 2-fold higher sensitivity and similar specificity. The results demonstrate the potentials of this new amplification technology, which permits improving current classic ELISA sensitivity limits

  11. A New ELISA Using the ANANAS Technology Showing High Sensitivity to diagnose the Bovine Rhinotracheitis from Individual Sera to Pooled Milk.

    Directory of Open Access Journals (Sweden)

    Elisabetta Casarin

    Full Text Available Diagnostic tests for veterinary surveillance programs should be efficient, easy to use and, possibly, economical. In this context, classic Enzyme linked ImmunoSorbent Assay (ELISA remains the most common analytical platform employed for serological analyses. The analysis of pooled samples instead of individual ones is a common procedure that permits to certify, with one single test, entire herds as "disease-free". However, diagnostic tests for pooled samples need to be particularly sensitive, especially when the levels of disease markers are low, as in the case of anti-BoHV1 antibodies in milk as markers of Infectious Bovine Rhinotracheitis (IBR disease. The avidin-nucleic-acid-nanoassembly (ANANAS is a novel kind of signal amplification platform for immunodiagnostics based on colloidal poly-avidin nanoparticles that, using model analytes, was shown to strongly increase ELISA test performance as compared to monomeric avidin. Here, for the first time, we applied the ANANAS reagent integration in a real diagnostic context. The monoclonal 1G10 anti-bovine IgG1 antibody was biotinylated and integrated with the ANANAS reagents for indirect IBR diagnosis from pooled milk mimicking tank samples from herds with IBR prevalence between 1 to 8%. The sensitivity and specificity of the ANANAS integrated method was compared to that of a classic test based on the same 1G10 antibody directly linked to horseradish peroxidase, and a commercial IDEXX kit recently introduced in the market. ANANAS integration increased by 5-fold the sensitivity of the 1G10 mAb-based conventional ELISA without loosing specificity. When compared to the commercial kit, the 1G10-ANANAS integrated method was capable to detect the presence of anti-BHV1 antibodies from bulk milk of gE antibody positive animals with 2-fold higher sensitivity and similar specificity. The results demonstrate the potentials of this new amplification technology, which permits improving current classic ELISA

  12. Molecular docking and dynamic studies of human growth factor receptorbound protein (Grb 2 insights to identify novel inhibitors

    Directory of Open Access Journals (Sweden)

    Sandeep S

    2016-10-01

    Full Text Available Background: Human growth factor receptor bound protein-2 (Grb 2 involves in initiation of kinase signaling by Son of Sevenless (SOS and activates mitogen activated protein kinase pathway. Grb2 overexpress during cancerous condition hence it emerged as a potent target for various cancers. Material and Methods: Seven pharmacophores were developed from seven co-crystal structures of Grb2 and applied for common pharmacophore hypothesis. Two common pharmacophore hypothesis (CPH models were screened and hits were applied for docking and free energy [G] calculations. Results: Two leads were proposed from docking and G analysis. Energy of the system, RMSD, RMSF, hydrogen bonds and water bridges of lead1 was better than the co-crystal ligand during 50 ns molecular dynamics simulations. Discussion: Two leads are interacting with Src homology 2 (SH2 domain of Grb2 and blocking the function of Grb2.

  13. Late Time Observations of the Afterglow and Environment of GRB 030329

    CERN Document Server

    Taylor, G B; Pihlström, Y M; Ghosh, T; Salter, C

    2004-01-01

    We present Very Long Baseline Interferometry (VLBI) observations 217 days after the gamma-ray burst of 2003 March 29. These observations provide further measurements of the size and position of GRB 030329 that are used to constrain the expansion rate and proper motion of this nearby GRB. The expansion rate appears to be slowing down with time, favoring expansion into a constant density interstellar medium, rather than a circumstellar wind with an r^-2 density profile. We also present late time Arecibo observations of the redshifted HI and OH absorption spectra towards GRB 030329. No absorption (or emission) is seen allowing us to place limits on the atomic neutral hydrogen of N_H < 8.5 x 10^20 cm^-2, and molecular hydrogen of N_H_2 < 1.4 x 10^22 cm^-2. Finally, we present VLA limits on the radio polarization from the afterglow of <2% at late times.

  14. Simulations of GRB detections with the ECLAIRs telescope onboard the future SVOM mission

    CERN Document Server

    Antier, S; Cordier, B; Gros, A; Götz, D; Lachaud, C

    2015-01-01

    The soft gamma-ray telescope ECLAIRs with its Scientific Trigger Unit is in charge of detecting Gamma-Ray Bursts (GRBs) on-board the future SVOM satellite. Using the "scientific software model" (SSM), we study the efficiency of both implemented trigger algorithms, the Count-Rate Trigger for time-scales below 20s and the Image Trigger for larger ones. The SMM provides a simulation of ECLAIRs with photon projection through the coded-mask onto the detection plane. We developed an input GRB database for the SSM based on GRBs light curves detected by the Fermi GBM instrument. We extrapolated the GRB spectra into the ECLAIRs band (4-120 keV) and projected them onto the detection plane, superimposed with cosmic extragalactic background photons (CXB). Several simulations were performed by varying the GRB properties (fluxes and positions in the field of view). We present first results of this study in this paper.

  15. The gamma-ray burst GRB060614 requires a novel explosive process

    CERN Document Server

    Gal-Yam, A; Price, P; Davis, M; Leonard, D; Soderberg, A M; Nakar, E; Ofek, E; Schmidt, B; Lewis, K; Peterson, B; Kulkarni, S; Berger, E; Cenko, B; Sari, R; Sharon, K; Frail, D A; Gehrels, N; Nousek, J; Burrows, D; Mangano, V; Holland, S; Brown, P; Moon, D S; Harrison, F; Piran, T; McCarthy, P; Penprase, B; Chevalier, R

    2006-01-01

    Over the past decade our physical understanding of gamma-ray bursts (GRBs) has progressed rapidly thanks to the discovery and observation of their long-lived afterglow emission. Long-duration (T 2 s) GRBs arise from a different origin, which has been argued to be the merger of two compact objects, either neutron stars or black holes. Here we present observations of GRB060614, a 100-s long burst discovered by the Swift satellite, which require the invocation of a new explosive process: either a massive ``collapsar'' that powers a GRB without any associated supernova, or a new type of engine, as long-lived as the collapsar but without any such massive stellar host. We also discuss the properties of this burst's redshift z=0.125 host galaxy, which distinguish it from other long-duration GRBs and suggest that an entirely new type of GRB progenitor may be required.

  16. The nature of GRB-selected submillimeter galaxies: hot and young

    CERN Document Server

    Michałowski, M J; Cerón, J M Castro; Watson, D

    2007-01-01

    We present detailed fits of the spectral energy distributions (SEDs) of four submillimeter (submm) galaxies selected by the presence of a gamma-ray burst (GRB) event (GRBs 980703, 000210, 000418 and 010222). These faint ~3 mJy submm emitters at redshift ~1 are characterized by an unusual combination of long- and short-wavelength properties, namely enhanced submm and/or radio emission combined with optical faintness and blue colors. We exclude an active galactic nucleus as the source of long-wavelength emission. From the SED fits we conclude that the four galaxies are young (ages 45 K) indicate that GRB host galaxies are hotter, younger, and less massive counterparts to submm-selected galaxies detected so far. Future facilities like Herschel, JCMT/SCUBA-2 and ALMA will test this hypothesis enabling measurement of dust temperatures of fainter GRB-selected galaxies.

  17. A new model of the central engine of GRB and the cosmic jets

    Science.gov (United States)

    Fiziev, P.; Staicova, D.

    Despite the volume of already existing observational data, current models still cannot explain completely the excessive energy output and the time variability of gamma-ray bursts(GRB). One of the reasons for this is the lack of a good model of the central engine of GRB. A major problem in the proposed models with a black hole (BH) in the center is that they don't explain the observed evidences of late time activity of the central engine. In this paper we are starting the search for a possible model of that central engine as a rotating compact body of still unknown nature. The formation of jets in the new model lies entirely on the fundamental Teukolsky Master Equation. We demonstrate that this general model can describe the formation of collimated GRB-jets of various forms. Some preliminary results are presented.

  18. A new model of the Central Engine of GRB and the Cosmic Jets

    CERN Document Server

    Fiziev, P P

    2009-01-01

    Despite all the already existing observational data, current models still cannot explain completely the excessive energy output and the time variability of GRB. One of the reasons for this is the lack of a good model of the central engine of GRB. A major problem in the proposed models with a black hole (BH) in the center is that they don't explain the observed evidences of late time activity of the central engine. In this paper we are starting the search for a possible model of that central engine as a rotating compact body of still unknown nature. The formation of jets in the new model lies entirely on the fundamental Teukolsky Master Equation. We demonstrate that this general model can describe the formation of collimated GRB-jets of various forms. Some preliminary results are presented.

  19. The local energy production rates of GRB photons and of UHECRs

    CERN Document Server

    Waxman, Eli

    2010-01-01

    In a recent analysis it was found that the local (z=0) rate at which gamma-ray bursts (GRBs) produce energy in 1 MeV photons, Q_GRB(z=0), is 300 times lower than the local energy production rate in ultra-high energy cosmic-rays. This may appear to be in contradiction with earlier results, according to which Q_GRB(z=0) is similar to the local energy production rate in >10^{19} eV cosmic-rays, Q_{10EeV}(z=0). This short (1 page) note identifies the origin of the apparent discrepancy and shows that Q_GRB(z=0) Q_{10EeV}(z=0) holds.

  20. Physical conditions and element abundances in SN and GRB host galaxies at different redshifts

    CERN Document Server

    Contini, M

    2016-01-01

    We compare the physical parameters and the relative abundances calculated throughout supernova (SN) and gamma-ray burst (GRB) host galaxies by the detailed modelling of the spectra. The results show that : 1) shock velocities are lower in long period GRB (LGRB) than in SN host galaxies. 2) O/H relative abundance in SN hosts are scattered within a range 8.0 10^5 K. Ts in LGRB hosts are 3-8 10^4 K. 4) Ha increases with the ionization parameter U. We suggest that SN-host symbiosis is stronger in terms of host galaxy activity than GRB-host in the range of energies related to the near UV - optical - near IR spectra.

  1. Evidence of Bulk Acceleration of the GRB X-Ray Flare Emission Region

    Science.gov (United States)

    Uhm, Z. Lucas; Zhang, Bing

    2016-06-01

    Applying our recently developed generalized version of the high-latitude emission theory to the observations of X-ray flares in gamma-ray bursts (GRBs), here we present clear observational evidence that the X-ray flare emission region is undergoing rapid bulk acceleration as the photons are emitted. We show that both the observed X-ray flare light curves and the photon index evolution curves can be simultaneously reproduced within a simple physical model invoking synchrotron radiation in an accelerating emission region far from the GRB central engine. Such an acceleration process demands an additional energy dissipation source other than kinetic energy, which points toward a significant Poynting flux in the emission region of X-ray flares. As the X-ray flares are believed to share a similar physical mechanism as the GRB prompt emission, our finding here hints that the GRB prompt emission jets may also carry a significant Poynting flux in their emitting region.

  2. A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep.

    Science.gov (United States)

    Rétey, J V; Adam, M; Khatami, R; Luhmann, U F O; Jung, H H; Berger, W; Landolt, H-P

    2007-05-01

    Caffeine is the most widely used stimulant in Western countries. Some people voluntarily reduce caffeine consumption because it impairs the quality of their sleep. Studies in mice revealed that the disruption of sleep after caffeine is mediated by blockade of adenosine A2A receptors. Here we show in humans that (1) habitual caffeine consumption is associated with reduced sleep quality in self-rated caffeine-sensitive individuals, but not in caffeine-insensitive individuals; (2) the distribution of distinct c.1083T>C genotypes of the adenosine A2A receptor gene (ADORA2A) differs between caffeine-sensitive and -insensitive adults; and (3) the ADORA2A c.1083T>C genotype determines how closely the caffeine-induced changes in brain electrical activity during sleep resemble the alterations observed in patients with insomnia. These data demonstrate a role of adenosine A2A receptors for sleep in humans, and suggest that a common variation in ADORA2A contributes to subjective and objective responses to caffeine on sleep.

  3. The Supercritical Pile Gamma-Ray Burst Model: The GRB Afterglow Steep Decline and Plateau Phase

    Science.gov (United States)

    Sultana, Joseph; Kazanas, D.; Mastichiadis, A.

    2013-01-01

    We present a process that accounts for the steep decline and plateau phase of the Swift X-Ray Telescope (XRT) light curves, vexing features of gamma-ray burst (GRB) phenomenology. This process is an integral part of the "supercritical pile" GRB model, proposed a few years ago to account for the conversion of the GRB kinetic energy into radiation with a spectral peak at E(sub pk) is approx. m(sub e)C(exp 2). We compute the evolution of the relativistic blast wave (RBW) Lorentz factor Gamma to show that the radiation-reaction force due to the GRB emission can produce an abrupt, small (approx. 25%) decrease in Gamma at a radius that is smaller (depending on conditions) than the deceleration radius R(sub D). Because of this reduction, the kinematic criticality criterion of the "supercritical pile" is no longer fulfilled. Transfer of the proton energy into electrons ceases and the GRB enters abruptly the afterglow phase at a luminosity smaller by approx. m(sub p)/m(sub e) than that of the prompt emission. If the radius at which this slow-down occurs is significantly smaller than R(sub D), the RBW internal energy continues to drive the RBW expansion at a constant (new) Gamma and its X-ray luminosity remains constant until R(sub D) is reached, at which point it resumes its more conventional decay, thereby completing the "unexpected" XRT light curve phase. If this transition occurs at R is approx. equal to R(sub D), the steep decline is followed by a flux decrease instead of a "plateau," consistent with the conventional afterglow declines. Besides providing an account of these peculiarities, the model suggests that the afterglow phase may in fact begin before the RBW reaches R is approx. equal to R(sub D), thus providing novel insights into GRB phenomenology.

  4. GRB 080503 LATE AFTERGLOW RE-BRIGHTENING: SIGNATURE OF A MAGNETAR-POWERED MERGER-NOVA

    Energy Technology Data Exchange (ETDEWEB)

    Gao, He; Ding, Xuan; Wu, Xue-Feng [Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008 (China); Dai, Zi-Gao [School of Astronomy and Space Science, Nanjing University, Nanjing 2100093 (China); Zhang, Bing, E-mail: hug18@psu.edu, E-mail: xfwu@pmo.ac.cn, E-mail: dzg@nju.edu.cn, E-mail: zhang@physics.unlv.edu [Department of Physics and Astronomy, University of Nevada Las Vegas, NV 89154 (United States)

    2015-07-10

    GRB 080503 is a short gamma-ray burst (GRB) detected by Swift and has been classified as a GRB originating from a compact star merger. The soft extended emission and the simultaneous late re-brightening in both the X-ray and optical afterglow light curves raise interesting questions regarding its physical origin. We show that the broadband data of GRB 080503 can be well explained within the framework of the double neutron star merger model, provided that the merger remnant is a rapidly rotating massive neutron star with an extremely high magnetic field (i.e., a millisecond magnetar). We show that the late optical re-brightening is consistent with the emission from a magnetar-powered “merger-nova.” This adds one more case to the growing sample of merger-novae associated with short GRBs. The soft extended emission and the late X-ray excess emission are well connected through a magnetar dipole spin-down luminosity evolution function, suggesting that direct magnetic dissipation is the mechanism to produce these X-rays. The X-ray emission initially leaks from a hole in the merger ejecta pierced by the short GRB jet. The hole subsequently closes after the magnetar spins down and the magnetic pressure drops below ram pressure. The X-ray photons are then trapped behind the merger-nova ejecta until the ejecta becomes optically thin at a later time. This explains the essentially simultaneous re-brightening in both the optical and X-ray light curves. Within this model, future gravitational-wave sources could be associated with a bright X-ray counterpart along with the merger-nova, even if the short GRB jet beams away from Earth.

  5. The supercritical pile gamma-ray burst model: The GRB afterglow steep decline and plateau phase

    Energy Technology Data Exchange (ETDEWEB)

    Sultana, J. [Mathematics Department, Faculty of Science, University of Malta, Msida MSD2080 (Malta); Kazanas, D. [Astrophysics Science Division, NASA/Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Mastichiadis, A., E-mail: joseph.sultana@um.edu.mt [Department of Physics, University of Athens, Panepistimiopolis, GR 15783 Zografos (Greece)

    2013-12-10

    We present a process that accounts for the steep decline and plateau phase of the Swift X-Ray Telescope (XRT) light curves, vexing features of gamma-ray burst (GRB) phenomenology. This process is an integral part of the 'supercritical pile' GRB model, proposed a few years ago to account for the conversion of the GRB kinetic energy into radiation with a spectral peak at E {sub pk} ∼ m{sub e}c {sup 2}. We compute the evolution of the relativistic blast wave (RBW) Lorentz factor Γ to show that the radiation-reaction force due to the GRB emission can produce an abrupt, small (∼25%) decrease in Γ at a radius that is smaller (depending on conditions) than the deceleration radius R{sub D} . Because of this reduction, the kinematic criticality criterion of the 'supercritical pile' is no longer fulfilled. Transfer of the proton energy into electrons ceases and the GRB enters abruptly the afterglow phase at a luminosity smaller by ∼m{sub p} /m{sub e} than that of the prompt emission. If the radius at which this slow-down occurs is significantly smaller than R{sub D} , the RBW internal energy continues to drive the RBW expansion at a constant (new) Γ and its X-ray luminosity remains constant until R{sub D} is reached, at which point it resumes its more conventional decay, thereby completing the 'unexpected' XRT light curve phase. If this transition occurs at R ≅ R{sub D} , the steep decline is followed by a flux decrease instead of a 'plateau,' consistent with the conventional afterglow declines. Besides providing an account of these peculiarities, the model suggests that the afterglow phase may in fact begin before the RBW reaches R ≅ R{sub D} , thus providing novel insights into GRB phenomenology.

  6. Grb7 and Hax1 may colocalize partially to mitochondria in EGF treated SKBR3 cells and their interaction can affect Caspase3 cleavage of Hax1

    Science.gov (United States)

    Qian, Lei; Bradford, Andrew M.; Cooke, Peter H.; Lyons, Barbara A.

    2017-01-01

    Growth factor receptor bound protein 7 (Grb7) is a signal transducing adaptor protein that mediates specific protein-protein interactions in multiple signaling pathways. Grb7, with Grb10 and Grb14, are members of the Grb7 protein family. The topology of the Grb7 family members contains several protein-binding domains that facilitate the formation of protein complexes and high signal transduction efficiency. Grb7 has been found overexpressed in several types of cancers and cancer cell lines, and is presumed involved in cancer progression through promotion of cell proliferation and migration via interactions with the ErbB2 (HER2) receptor, FAK (focal adhesion kinase), Ras-GTPases, and other signaling partners. We previously reported Grb7 binds to Hax1 (HS1 associated protein X1) isoform 1, an anti-apoptotic protein also involved in cell proliferation and calcium homeostasis. In this study, we confirm the in vitro Grb7/Hax1 interaction is exclusive to these two proteins and their interaction does not depend on Grb7 dimerization state. In addition, we report Grb7 and Hax1 isoform 1 may colocalize partially to mitochondria in EGF treated SKBR3 cells and growth conditions can affect this colocalization. Moreover, Grb7 can affect Caspase3 cleavage of the Hax1 isoform 1 in vitro, and Grb7 expression may slow the Caspase3 cleavage of Hax1 isoform 1 in apoptotic HeLa cells. Finally, Grb7 is shown to increase cell viability in apoptotic HeLa cells in a time dependent manner. Taken together, these discoveries provide clues for the role of a Grb7/Hax1 protein interaction in apoptosis pathways involving Hax1. PMID:26869103

  7. The Prevalence of Antibiotic and Toothpaste Sensitivity found in Oral Streptococcal Isolates in Healthy Individuals in the Okada Community of Nigeria

    Directory of Open Access Journals (Sweden)

    Maureen U Okwu

    2017-04-01

    Full Text Available Background: This study aimed to determine the prevalence, antibiotic, and toothpaste sensitivity of oral streptococcal isolates in healthy individuals in the Okada community of Nigeria. Methods: Oral samples were collected from 230 volunteers and were subjected to standard microbiological tests. Antibacterial sensitivity tests were carried out on the streptococcal isolates that were obtained using a disk diffusion technique, and eight kinds of toothpaste (A-H were screened for their antibacterial effects on Streptococcus mutans (S. mutans. Results: The prevalence of oral streptococci found in this study was 26.1% and the predominant species was S. salivarius (13.9%. S. salivarius was highly resistant to cloxacillin (100% and Augmentin (96.9%, whilst resistance to gentamicin and erythromycin was low at 21.9% and 3.1% respectively. S. mutans were completely sensitive to gentamicin whilst resistance to erythromycin was 33.3%. The entire Streptococcus species showed the lowest resistance to erythromycin (20.0%, followed by gentamicin (31.7%. At 100 mg/mL all toothpaste samples had antibacterial effects on S. mutans. At 50 mg/mL all samples except toothpastes G and H inhibited the bacterium. Toothpastes A and E had the lowest minimum inhibitory concentration of 25 mg/mL. Conclusions: Toothpastes A and E were the most effective toothpastes of the eight assessed in this study.

  8. High-sensitive and rapid detection of Mycobacterium tuberculosis infection by IFN-γ release assay among HIV-infected individuals in BCG-vaccinated area

    Directory of Open Access Journals (Sweden)

    Jiang Weimin

    2009-05-01

    Full Text Available Abstract Background An accurate test for Mycobacterium tuberculosis infection is urgently needed in immunosuppressed populations. The aim of this study was to investigate the diagnostic power of enzyme-linked immunospot (ELISPOT-based IFN-γ release assay in detecting active and latent tuberculosis in HIV-infected population in bacillus Calmette-Guerin (BCG-vaccinated area. A total of 100 HIV-infected individuals including 32 active tuberculosis patients were recruited. An ELISPOT-based IFN-γ release assay, T-SPOT.TB, was used to evaluate the M. tuberculosis ESAT-6 and CFP-10 specific IFN-γ response. Tuberculin skin test (TST was performed for all recruited subjects. Results The subjects were divided into group HIV+ATB (HIV-infected individuals with active tuberculosis, n = 32, group HIV+LTB (HIV-infected individuals with positive results of T-SPOT.TB assay, n = 46 and group HIV only (HIV-infected individuals with negative results of T-SPOT.TB assay and without evidence of tuberculosis infection, n = 22. In group HIV+ATB and HIV+LTB, T-SPOT.TB positive rate in subjects with TST P 85% in patients with TB treatment for less than 1 month and CD4+ T cells ≥200/μl, while for patients treated for more than 3 months and CD4+ T cells Conclusion ELISPOT-based IFN-γ release assay is more sensitive and rapid for the diagnosis of TB infection in Chinese HIV-infected individuals with history of BCG vaccination, and could be an effective tool for guiding preventive treatment with isoniazid in latently infected people and for TB control in China.

  9. Preliminary Results on VLT K-band Imaging Observations of GRB Host Galaxies

    Indian Academy of Sciences (India)

    E. Le Floc’h; I. F. Mirabel; P.-A. Duc

    2002-03-01

    We have obtained -band imaging observations of Gamma-Ray Burst (GRB) host galaxies with the near-infrared spectro-imager ISAAC installed on the Very Large Telescope at Paranal (Chile). The derived magnitudes, combined with other photometric data taken from the literature, are used to investigate the – colors of GRB hosts. We do not find any extremely reddened starbursts in our sample, despite the capability of GRBs to trace star formation even in dusty regions. The observed – colors are on the contrary typical of irregular and spiral blue galaxies at high redshift.

  10. Four Years of Real-Time GRB Followup by BOOTES-1B (2005–2008

    Directory of Open Access Journals (Sweden)

    Martin Jelínek

    2010-01-01

    Full Text Available Four years of BOOTES-1B GRB follow-up history are summarised for the first time in the form of a table. The successfully followed events are described case by case. Further, the data are used to show the GRB trigger rate in Spain on a per-year basis, resulting in an estimate of 18 triggers and about 51 hours of telescope time per year for real-time triggers. These numbers grow to about 22 triggers and 77 hours per year if we include also the GRBs observable within 2 hours after the trigger.

  11. Reviewing the case of the atypical central-engine activity in GRB 110709B

    CERN Document Server

    Fraija, Nissim; Patricelli, Barbara

    2015-01-01

    The unusual GRB 110709B triggered Swift/BAT twice, with a time difference of $\\sim 11$ minutes. Its light curve presented three noticeable peaks but only two were originally identified. In this work, we describe each peak as due to a different central-engine phase: the first one is the millisecond-protomagnetar stage, the second one is the BH-formation collapse phase and the last one is the Collapsar scenario with a Blandford-Znajek engine. Additionally, we analyze and explain the afterglow phase evoking the standard fireball model. Our model can successfully describe the timescales, fluxes and spectral indices observed for GRB 110709B.

  12. GRB observed by IBIS/PICsIT in the MeV energy range

    Energy Technology Data Exchange (ETDEWEB)

    Bianchin, V.; Foschini, L.; Di Cocco, G.; Gianotti, F.; Malaguti, G.; Schiavone, F. [INAF, IASF Bologna, I-40129 Bologna, (Italy); Gotz, D.; Laurent, P. [CEA, IRFU, SAp, F-91191 Gif Sur Yvette, (France); Laurent, P. [APC, F-75205 Paris, (France)

    2009-07-01

    We present the preliminary results of a systematic search for GRB and other transients ill the publicly available data for the IBIS/PICsIT (0.2-10 MeV) detector on board INTEGRAL. Light curves in 2-8 energy bands with time resolution from 1 to 62.5 ms have been collected and an analysis of spectral and temporal characteristics has been performed. This is the nucleus of a forthcoming first catalog of GRB observed by PICsIT. (authors)

  13. GRB 070714B - Discovery of the Highest Spectroscopically Confirmed Short Burst Redshift

    CERN Document Server

    Graham, J F; Levan, A J; Nysewander, M; Tanvir, N R; Dahlen, T; Bersier, D; Peér, A

    2008-01-01

    Gemini Nod & Shuffle spectroscopy on the host of the short GRB 070714B shows a single emission line at 7167 angstroms which, based on a grizJHK photometric redshift, we conclude is the 3727 angstrom [O II] line. This places the host at a redshift of z=.923 exceeding the previous record for the highest spectroscopically confirmed short burst redshift of z=.546 held by GRB 051221. This dramatically moves back the time at which we know short bursts were being formed, and suggests that the present evidence for an old progenitor population may be observationally biased.

  14. Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1.

    Science.gov (United States)

    Schuster-Gossler, Karin; Cordes, Ralf; Müller, Julia; Geffers, Insa; Delany-Heiken, Patricia; Taft, Manuel; Preller, Matthias; Gossler, Achim

    2016-03-01

    The highly conserved Notch-signaling pathway mediates cell-to-cell communication and is pivotal for multiple developmental processes and tissue homeostasis in adult organisms. Notch receptors and their ligands are transmembrane proteins with multiple epidermal-growth-factor-like (EGF) repeats in their extracellular domains. In vitro the EGF repeats of mammalian ligands that are essential for Notch activation have been defined. However, in vivo the significance of the structural integrity of each EGF repeat in the ligand ectodomain for ligand function is still unclear. Here, we analyzed the mouse Notch ligand DLL1. We expressed DLL1 proteins with mutations disrupting disulfide bridges in each individual EGF repeat from single-copy transgenes in the HPRT locus of embryonic stem cells. In Notch transactivation assays all mutations impinged on DLL1 function and affected both NOTCH1 and NOTCH2 receptors similarly. An allelic series in mice that carried the same point mutations in endogenous Dll1, generated using a mini-gene strategy, showed that early developmental processes depending on DLL1-mediated NOTCH activation were differently sensitive to mutation of individual EGF repeats in DLL1. Notably, some mutations affected only somite patterning and resulted in vertebral column defects resembling spondylocostal dysostosis. In conclusion, the structural integrity of each individual EGF repeat in the extracellular domain of DLL1 is necessary for full DLL1 activity, and certain mutations in Dll1 might contribute to spondylocostal dysostosis in humans.

  15. Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation

    Directory of Open Access Journals (Sweden)

    Pero Stephanie C

    2007-09-01

    Full Text Available Abstract Background Human growth factor receptor bound protein 7 (Grb7 is an adapter protein that mediates the coupling of tyrosine kinases with their downstream signaling pathways. Grb7 is frequently overexpressed in invasive and metastatic human cancers and is implicated in cancer progression via its interaction with the ErbB2 receptor and focal adhesion kinase (FAK that play critical roles in cell proliferation and migration. It is thus a prime target for the development of novel anti-cancer therapies. Recently, an inhibitory peptide (G7-18NATE has been developed which binds specifically to the Grb7 SH2 domain and is able to attenuate cancer cell proliferation and migration in various cancer cell lines. Results As a first step towards understanding how Grb7 may be inhibited by G7-18NATE, we solved the crystal structure of the Grb7 SH2 domain to 2.1 Å resolution. We describe the details of the peptide binding site underlying target specificity, as well as the dimer interface of Grb 7 SH2. Dimer formation of Grb7 was determined to be in the μM range using analytical ultracentrifugation for both full-length Grb7 and the SH2 domain alone, suggesting the SH2 domain forms the basis of a physiological dimer. ITC measurements of the interaction of the G7-18NATE peptide with the Grb7 SH2 domain revealed that it binds with a binding affinity of Kd = ~35.7 μM and NMR spectroscopy titration experiments revealed that peptide binding causes perturbations to both the ligand binding surface of the Grb7 SH2 domain as well as to the dimer interface, suggesting that dimerisation of Grb7 is impacted on by peptide binding. Conclusion Together the data allow us to propose a model of the Grb7 SH2 domain/G7-18NATE interaction and to rationalize the basis for the observed binding specificity and affinity. We propose that the current study will assist with the development of second generation Grb7 SH2 domain inhibitors, potentially leading to novel inhibitors of

  16. A Survey for NV Absorption at z~z_GRB in GRB Afterglow Spectra: Clues to Gas Near the Progenitor Star

    CERN Document Server

    Prochaska, Jason X; Ramirez-Ruiz, Enrico; Chen, Hsiao-Wen

    2008-01-01

    We survey NV absorption in the afterglow spectra of long-duration gamma-ray bursts (GRBs) with the intent to study highly ionized gas in the galaxies hosting these events. We identify a high incidence (6/7) of spectra exhibiting NV gas with z~z_GRB and the majority show large column densities NV > 10^14 cm^-2. With one exception, the observed line-profiles are kinematically `cold', i.e. they are narrow and have small velocity offset (Dv 10^3 cm^-3) environments, typical of molecular clouds. The observations, therefore, primarily constrain the physical conditions -- metallicity, density, velocity fields -- of the gas within the (former) molecular cloud region surrounding the GRB.

  17. On the constraining observations of the dark GRB 001109 and the properties of a z=0.398 radio selected starburst galaxy contained in its error box

    DEFF Research Database (Denmark)

    Ceron, J.M.C.; Gorosabel, J.; Castro-Tirado, A.J.;

    2004-01-01

    We present optical and NIR (near infrared) follow up observations of the GRB 001109 from 1 to 300 days after the burst. No transient emission was found at these wavelengths within this GRB's (Gamma Ray Burst) 50" radius BeppoSAX error box. Strong limits (3sigma) are set with: Rgreater than...... or similar to21, 10.2 h after the GRB; Igreater than or similar to23, 11.4 h after the GRB; Hgreater than or similar to20.7, 9.9 h after the GRB; and K(S)greater than or similar to20, 9.6 h after the GRB. We discuss whether the radio source found in the GRB's error box (Taylor et al. 2000) might be related...

  18. Survival of patients with limited-stage small cell lung cancer treated with individualized chemotherapy selected by in vitro drug sensitivity testing.

    Science.gov (United States)

    Cortazar, P; Gazdar, A F; Woods, E; Russell, E; Steinberg, S M; Williams, J; Ihde, D C; Johnson, B E

    1997-05-01

    Our purpose was to study the feasibility of determining individualized chemotherapy regimens by in vitro drug sensitivity testing (DST) for patients with limited-stage small cell lung cancer (SCLC) and to evaluate patient response and survival. Fifty-four previously untreated patients with limited-stage small cell cancer were studied. Fresh tumor specimens for DST were collected, when possible, from patients' biopsies before the start of treatment. The differential staining cytotoxicity assay was used to determine the in vitro sensitivity of the tumor cells to different drugs. From these results, an in vitro best regimen (IVBR), a three-drug combination of previously proven efficacy of seven active drugs in SCLC, was selected. Patients were initially treated with four cycles of etoposide/cisplatin and concurrent radiotherapy. This was followed by four cycles of either individualized chemotherapy regimens based on the results of DST or, when DST results were not available, four cycles of vincristine, doxorubicin, and cyclophosphamide. Eighteen patients (33%) underwent biopsy procedures that provided tissue specimens for DST. The biopsy specimens contained tumor cells in 16 of 18 patients. The median duration from diagnosis to start of treatment was 22 days (range, 4-58 days) for the 18 patients who underwent elective thoracic biopsies compared to 21 days (range, 2-74 days) for members of the group that did not (P2 = 0.58). Time from thoracic biopsy to initiation of chemotherapy was a median of 4 days (range, 2-22 days). DST was done in 10 patients, and IVBR was administered to 8 patients. The median actuarial survival of 8 patients treated with their IVBR was 38.5 months compared to 19 months for the 46 patients treated with empiric chemotherapy. Selection of individualized chemotherapy regimens is labor intensive but feasible in limited-stage SCLC. Treatment with an individualized IVBR in our patients was associated with prolonged patient survival; however, because

  19. The circumburst environment of a FRED GRB: study of the prompt emission and X-ray/optical afterglow of GRB 051111

    CERN Document Server

    Guidorzi, C; Kobayashi, S; Mundell, C G; Rol, E; Bode, M F; Carter, D; La Parola, V; Melandri, A; Monfardini, A; Mottram, C J; O'Brien, P T; Page, K L; Sakamoto, T; Smith, R J; Steele, I A; Tanvir, N R

    2006-01-01

    We report a multi-wavelength analysis of the prompt emission and early afterglow of GRB051111 and discuss its properties in the context of current fireball models. The detection of GRB051111 by the Burst Alert Telescope on-board Swift triggered early BVRi' observations with the 2-m robotic Faulkes Telescope North in Hawaii, as well as X-ray observations with the Swift X-Ray Telescope. The prompt gamma-ray emission shows a classical FRED profile. The optical afterglow light curves are fitted with a broken power law, with alpha_1=0.35 to alpha_2=1.35 and a break time around 12 minutes after the GRB. Although contemporaneous X-ray observations were not taken, a power law connection between the gamma-ray tail of the FRED temporal profile and the late XRT flux decay is feasible. Alternatively, if the X-ray afterglow tracks the optical decay, this would represent one of the first GRBs for which the canonical steep-shallow-normal decay typical of early X-ray afterglows has been monitored optically. We present a deta...

  20. A sensitive, reproducible and objective immunofluorescence analysis method of dystrophin in individual fibers in samples from patients with duchenne muscular dystrophy.

    Directory of Open Access Journals (Sweden)

    Chantal Beekman

    Full Text Available Duchenne muscular dystrophy (DMD is characterized by the absence or reduced levels of dystrophin expression on the inner surface of the sarcolemmal membrane of muscle fibers. Clinical development of therapeutic approaches aiming to increase dystrophin levels requires sensitive and reproducible measurement of differences in dystrophin expression in muscle biopsies of treated patients with DMD. This, however, poses a technical challenge due to intra- and inter-donor variance in the occurrence of revertant fibers and low trace dystrophin expression throughout the biopsies. We have developed an immunofluorescence and semi-automated image analysis method that measures the sarcolemmal dystrophin intensity per individual fiber for the entire fiber population in a muscle biopsy. Cross-sections of muscle co-stained for dystrophin and spectrin have been imaged by confocal microscopy, and image analysis was performed using Definiens software. Dystrophin intensity has been measured in the sarcolemmal mask of spectrin for each individual muscle fiber and multiple membrane intensity parameters (mean, maximum, quantiles per fiber were calculated. A histogram can depict the distribution of dystrophin intensities for the fiber population in the biopsy. This method was tested by measuring dystrophin in DMD, Becker muscular dystrophy, and healthy muscle samples. Analysis of duplicate or quadruplicate sections of DMD biopsies on the same or multiple days, by different operators, or using different antibodies, was shown to be objective and reproducible (inter-assay precision, CV 2-17% and intra-assay precision, CV 2-10%. Moreover, the method was sufficiently sensitive to detect consistently small differences in dystrophin between two biopsies from a patient with DMD before and after treatment with an investigational compound.

  1. The 80 Ms follow-up of the X-ray afterglow of GRB 130427A challenges the standard forward shock model

    Science.gov (United States)

    De Pasquale, M.; Page, M. J.; Kann, D. A.; Oates, S. R.; Schulze, S.; Zhang, B.; Cano, Z.; Gendre, B.; Malesani, D.; Rossi, A.; Troja, E.; Piro, L.; Boër, M.; Stratta, G.; Gehrels, N.

    2016-10-01

    GRB 130427A was the brightest gamma-ray burst detected in the last 30 yr. With an equivalent isotropic energy output of 8.5 × 1053 erg and redshift z = 0.34, it uniquely combined very high energetics with a relative proximity to Earth. As a consequence, its X-ray afterglow has been detected by sensitive X-ray observatories such as XMM-Newton and Chandra for a record-breaking baseline longer than 80 million seconds. We present the X-ray light curve of this event over such an interval. The light curve shows a simple power-law decay with a slope α = 1.309 ± 0.007 over more than three decades in time (47 ks-83 Ms). We discuss the consequences of this result for a few models proposed so far to interpret GRB 130427A, and more in general the significance of this outcome in the context of the standard forward shock model. We find that this model has difficulty in explaining our data, in both cases of constant density and stellar-wind circumburst media, and requires far-fetched values for the physical parameters involved.

  2. The 80 Ms follow-up of the X-ray afterglow of GRB 130427A challenges the standard forward shock model

    CERN Document Server

    De Pasquale, M; Kann, D A; Oates, S R; Schulze, S; Zhang, B; Cano, Z; Gendre, B; Malesani, D; Rossi, A; Troja, E; Piro, L; Boër, M; Stratta, G; Gehrels, N

    2016-01-01

    GRB 130427A was the brightest gamma-ray burst detected in the last 30 years. With an equivalent isotropic energy output of $8.5\\times10^{53}$ erg and redshift $z=0.34$, it uniquely combined very high energetics with a relative proximity to Earth. As a consequence, its X-ray afterglow has been detected by sensitive X-ray observatories such as XMM-Newton and Chandra for a record-breaking baseline longer than 80 million seconds. We present the X-ray light-curve of this event over such an interval. The light-curve shows a simple power-law decay with a slope $\\alpha = 1.309 \\pm 0.007$ over more than three decades in time (47 ks - 83 Ms). We discuss the consequences of this result for a few models proposed so far to interpret GRB 130427A, and more in general the significance of this outcome in the context of the standard forward shock model. We find that this model has difficulty in explaining our data, in both cases of constant density and stellar-wind circumburst media, and requires far-fetched values for the phy...

  3. Time-dependent excitation and ionization modelling of absorption-line variability due to GRB080310

    DEFF Research Database (Denmark)

    Vreeswijk, P.M.; De Cia, A.; Jakobsson, P.

    2013-01-01

    We model the time-variable absorption of Feii, Feiii, Siii, Cii and Crii detected in Ultraviolet and Visual Echelle Spectrograph (UVES) spectra of gamma-ray burst (GRB) 080310, with the afterglow radiation exciting and ionizing the interstellar medium in the host galaxy at a redshift of z = 2.427...

  4. Curvature Effect and the Spectral Softening Phenomenon Detected in GRB Afterglows

    Indian Academy of Sciences (India)

    Y.-P. Qin

    2011-03-01

    Detection of radiation from a relativistic fireball would be affected by the so-called curvature effect. I illustrate the expected temporal and spectral behaviours of this effect and show that it can well explain the observed spectral softening in the early GRB afterglows.

  5. The afterglow and complex environment of the optically dim burst GRB 980613

    DEFF Research Database (Denmark)

    Hjorth, J.; Thomsen, Bente; Nielsen, S.R.

    2002-01-01

    of the optical afterglow was mainly due to the fairly at spectral shape rather than internal reddening in the host galaxy. We also present late-time Hubble Space Telescope/Space Telescope Imaging Spectrograph images of the field in which GRB 980613 occurred, obtained 799 days after the burst. These images show...

  6. The extraordinarily bright optical afterglow of GRB 991208 and its host galaxy

    DEFF Research Database (Denmark)

    Castro-Tirado, A.J.; Sokolov, V.V.; Gorosabel, J.

    2001-01-01

    days. which is very likely due to the jet effect. and it is followed by a much steeper decay with constant -3.2 +/- 0.2. the fastest one ever seen in a GRB optical afterglow. A negative detection in several all-sky films taken simultaneously with the er ent. that otherwise would have reached naked eye...

  7. Swift observations of GRB050904: the most distant cosmic explosion ever observed

    CERN Document Server

    Cusumano, G; Chincarini, G; Panaitescu, A; Burrows, D N; La Parola, V; Sakamoto, T; Campana, S; Mineo, T; Tagliaferri, G; Angelini, L; Barthelemy, S D; Beardmore, A P; Boyd, P T; Cominsky, L; Gronwall, C; Fenimore, E E; Gehrels, N; Giommi, P; Goad, M; Hurley, K; Immler, S; Kennea, J A; Mason, K O; Marshall, F; Mészáros, P; Nousek, J A; Osborne, J P; Palmer, D M; Roming, P W A; Wells, A; White, N E; Zhang, B

    2006-01-01

    Swift discovered the high redshift (z=6.29) GRB050904 with the Burst Alert Telescope (BAT) and began observing with its narrow field instruments 161 s after the burst onset. This gamma-ray burst is the most distant cosmic explosion ever observed. Because of its high redshift, the X-ray Telescope (XRT) and BAT simultaneous observations provide 4 orders of magnitude of spectral coverage (0.2-150 keV; 1.4-1090 keV in the source rest frame) at a very early source-frame time (22 s). GRB050904 was a long, multi-peaked, bright GRB with strong variability during its entire evolution. The light curve observed by the XRT is characterized by the presence of a long flaring activity lasting up to 1-2 hours after the burst onset in the burst rest frame, with no evidence of a smooth power-law decay following the prompt emission as seen in other GRBs. However, the BAT tail extrapolated to the XRT band joins the XRT early light curve and the overall behavior resembles that of a very long GRB prompt. The spectral energy distri...

  8. GRB 110205A: Anatomy of a long gamma-ray burst

    CERN Document Server

    Gendre, B; Boër, M; Colas, F; Klotz, A; Kugel, F; Laas-Bourez, M; Rinner, C; Strajnic, J; Stratta, G; Vachier, F

    2011-01-01

    The Swift burst GRB 110205A was a very bright burst visible in the Northern hemisphere. GRB 110205A was intrinsically long and very energetic and it occurred in a low-density interstellar medium environment, leading to delayed afterglow emission and a clear temporal separation of the main emitting components: prompt emission, reverse shock, and forward shock. Our observations show several remarkable features of GRB 110205A : the detection of prompt optical emission strongly correlated with the BAT light curve, with no temporal lag between the two ; the detection of an X-ray excess above the extrapolation of the Band function measured in gamma-rays during the prompt phase ; and a large optical flare after the end of the prompt phase, that we interpret as a signature of the reverse shock. Beyond the pedagogical value offered by the excellent multi-wavelength coverage of a GRB with temporally separated radiating components, we discuss several questions raised by our observations: the nature of the prompt optical...

  9. GRB 090423: Marking the Death of a Massive Star at z=8.2

    CERN Document Server

    Lin, Lin; Nan, Zhang Shuang

    2009-01-01

    GRB 090423 is the new high-z record holder of Gamma-ray bursts (GRBs) with z~ 8.2. We present a detailed analysis of both the spectral and temporal features of GRB 090423 observed with Swift/BAT and Fermi/GBM. We find that the T90 observed with BAT in the 15-150 keV band is 13.2 s, corresponding to ~ 1.4 s at z=8.2. It once again gives rise to an issue whether the progenitors of high-z GRBs are massive stars or mergers since the discovery of GRB 080913 at z=6.7. In comparison with T90 distribution in the burst frame of current redshift-known GRB sample, we find that it is marginally grouped into the long group (Type II GRBs). The spectrum observed with both BAT and GBM is well fitted by a power-law with exponential cutoff, which yields an Ep=50.4+/-7.0 keV. The event well satisfies the Amati-relation for the Type II GRBs within their 3 siggma uncertainty range. Our results indicate that this event would be produced by the death of a massive star. Based on the Amati-relation, we derive its distance modulus, wh...

  10. X-ray spectral components observed in the afterglow of GRB 130925A

    DEFF Research Database (Denmark)

    Bellm, Eric C.; Barrière, Nicolas M.; Bhalerao, Varun

    2014-01-01

    We have identified spectral features in the late-time X-ray afterglow of the unusually long, slow-decaying GRB 130925A using NuSTAR, Swift/X-Ray Telescope, and Chandra. A spectral component in addition to an absorbed power law is required at >4σ significance, and its spectral shape varies between...

  11. VLT/X-shooter spectroscopy of the GRB 120327A afterglow

    DEFF Research Database (Denmark)

    D'Elia, V.; Fynbo, Johan Peter Uldall; Goldoni, P.;

    2014-01-01

    We present a study of the environment of the Swift long gamma-ray burst GRB 120327A at z ~2.8 through optical spectroscopy of its afterglow. We analyzed medium-resolution, multi-epoch spectroscopic observations (~7000 - 12000, corresponding to ~ 15 - 23 km/s, S/N = 15- 30 and wavelength range 3000...

  12. Rapid, Machine-Learned Resource Allocation: Application to High-redshift GRB Follow-up

    CERN Document Server

    Morgan, Adam N; Richards, Joseph W; Broderick, Tamara; Butler, Nathaniel R; Bloom, Joshua S

    2011-01-01

    As the number of observed Gamma-Ray Bursts (GRBs) continues to grow, follow-up resources need to be used more efficiently in order to maximize science output from limited telescope time. As such, it is becoming increasingly important to rapidly identify bursts of interest as soon as possible after the event, before the afterglows fade beyond detectability. Studying the most distant (highest redshift) events, for instance, remains a primary goal for many in the field. Here we present our Random forest Automated Triage Estimator for GRB redshifts (RATE GRB-z) for rapid identification of high-redshift candidates using early-time metrics from the three telescopes onboard Swift. While the basic RATE methodology is generalizable to a number of resource allocation problems, here we demonstrate its utility for telescope-constrained follow-up efforts with the primary goal to identify and study high-z GRBs. For each new GRB, RATE GRB-z provides a recommendation - based on the available telescope time - of whether the e...

  13. Spatially-resolved dust properties of the GRB 980425 host galaxy

    CERN Document Server

    Michałowski, Michał J; Palazzi, E; Savaglio, S; Gentile, G; Rasmussen, J; Baes, M; Basa, S; Bianchi, S; Berta, S; Burlon, D; Ceron, J M Castro; Covino, S; Cuby, J -G; D'Elia, V; Ferrero, P; Gotz, D; Hjorth, J; Koprowski, M P; Borgne, D Le; Floc'h, E Le; Malesani, D; Murphy, T; Pian, E; Piranomonte, S; Rossi, A; Sollerman, J; Tanvir, N R; Postigo, A de Ugarte; Watson, D; van der Werf, P; Vergani, S D; Xu, D

    2013-01-01

    Gamma-ray bursts (GRBs) have been proposed as a tool to study star formation in the Universe, so it is crucial to investigate whether their host galaxies and immediate environments are in any way special compared with other star-forming galaxies. Here we present spatially resolved maps of dust emission of the host galaxy of the closest known GRB 980425 at z=0.0085 using our new high-resolution observations from Herschel, APEX, ALMA and ATCA. We modeled the spectral energy distributions of the host and of the star-forming region displaying the Wolf-Rayet signatures in the spectrum (WR region), located 800 pc away from the GRB position. The host is characterised by low dust content and high fraction of UV-visible star-formation, similar to other dwarf galaxies. Such galaxies are abundant in the local universe, so it is not surprising to find a GRB in one of them, assuming the correspondence between the GRB rate and star-formation. The WR region contributes substantially to the host emission at the far-infrared,...

  14. GRB 090423:Marking the death of a massive star at z=8.2

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    GRB 090423 is the new high-z record holder of Gamma-ray bursts(GRBs) with z-8.2.We present a detailed analysis of both the spectral and temporal features of GRB 090423 observed with Swift/BAT and Fermi/GBM.We find that the T90 observed with BAT in the 15-150 keV band is 13.2 s,corresponding to-1.4 s at z=8.2.It once again gives rise to the issue of whether the progenitors of high-z GRBs are massive stars or mergers since the discovery of GRB 080913 at z=6.7.In comparison with the T90 distribution in the burst frame of the current redshift-known GRB sample,we find that it is marginally grouped into the long group(Type II GRBs).The spectrum observed with both BAT and GBM is well fitted by a power-law with exponential cutoff,which yields an Ep=(50.4±7.0) keV.The event satisfies the Amati-relation well for Type II GRBs within their 3σ uncertainty range.Our results indicate that this event would be produced by the death of a massive star.Based on the Amati-relation,we derive its distance modulus,which follows the Hubble diagram of the concordance cosmology model at a redshift of-8.2.

  15. The afterglow and complex environment of the optically dim burst GRB 980613

    DEFF Research Database (Denmark)

    Hjorth, J.; Thomsen, Bente; Nielsen, S.R.;

    2002-01-01

    of the optical afterglow was mainly due to the fairly at spectral shape rather than internal reddening in the host galaxy. We also present late-time Hubble Space Telescope/Space Telescope Imaging Spectrograph images of the field in which GRB 980613 occurred, obtained 799 days after the burst. These images show...

  16. Multiwavelength observations of the energetic GRB 080810: detailed mapping of the broad-band spectral evolution

    NARCIS (Netherlands)

    Page, K.L.; Willingale, R.; Bissaldi, E.; de Ugarte Postigo, A.; Holland, S.T.; McBreen, S.; O'Brien, P.T.; Osborne, J.P.; Prochaska, J.X.; Rol, E.; Rykoff, E.S.; Starling, R.L.C.; Tanvir, N.R.; van der Horst, A.J.; Wiersema, K.; Zhang, B.; Aceituno, F.J.; Akerlof, C.; Beardmore, A.P.; Briggs, M.S.; Burrows, D.N.; Castro-Tirado, A.J.; Connaughton, V.; Evans, P.A.; Fynbo, J.P.U.; Gehrels, N.; Guidorzi, C.; Howard, A.W.; Kennea, J.A.; Kouveliotou, C.; Pagani, C.; Preece, R.; Perley, D.; Steele, I.A.; Yuan, F.

    2009-01-01

    GRB 080810 was one of the first bursts to trigger both Swift and the Fermi Gamma-ray Space Telescope. It was subsequently monitored over the X-ray and UV/optical bands by Swift, in the optical by Robotic Optical Transient Search Experiment (ROTSE) and a host of other telescopes, and was detected in

  17. The rapidly flaring afterglow of the very bright and energetic GRB 070125

    NARCIS (Netherlands)

    Updike, A.C.; Haislip, J.B.; Nysewander, M.C.; Fruchter, A.S.; Kann, D.A.; Klose, S.; Milne, P.A.; Williams, G.G.; Zheng, W.; Hergenrother, C.W.; Prochaska, J.X.; Halpern, J.P.; Mirabal, N.; Thorstensen, J.R.; van der Horst, A.J.; Starling, R.L.C.; Racusin, J.L.; Burrows, D.N.; Kuin, N.P.M.; Roming, P.W.A.; Bellm, E.; Hurley, K.; Li, W.; Filippenko, A.V.; Blake, C.; Starr, D.; Falco, E.E.; Brown, W.R.; Dai, X.; Deng, J.; Xin, L.; Qiu, Y.; Wei, J.; Urata, Y.; Nanni, D.; Maiorano, E.; Palazzi, E.; Greco, G.; Bartolini, C.; Guarnieri, A.; Piccioni, A.; Pizzichini, G.; Terra, F.; Misra, K.; Bhatt, B.C.; Anupama, G.C.; Fan, X.; Jiang, L.; Wijers, R.A.M.J.; Reichart, D.E.; Eid, H.A.; Bryngelson, G.; Puls, J.; Goldthwaite, R.C.; Hartmann, D.H.

    2008-01-01

    We report on multiwavelength observations, ranging from X-ray to radio wave bands, of the IPN-localized gamma-ray burst GRB 070125. Spectroscopic observations reveal the presence of absorption lines due to O I, Si II, and C IV, implying a likely redshift of z = 1.547. The well-sampled light curves,

  18. The unusual afterglow of GRB 980326 evidence for the $\\gamma$-ray burst/supernova connection

    CERN Document Server

    Bloom, J S; Djorgovski, S G; Eichelberger, A C; Côté, P; Blakeslee, J P; Odewahn, S C; Harrison, F A; Frail, D A; Filippenko, A V; Leonard, D C; Riess, A G; Spinrad, H; Stern, D; Bunker, A J; Dey, A; Stanford, S A; Grossan, B; Perlmutter, S; Knop, R A; Hook, I M; Feroci, M

    1999-01-01

    Cosmic gamma-ray bursts (GRBs) have been firmly established as one of the most powerful phenomena in the Universe, releasing electromagnetic energy approaching the rest-mass energy of a neutron star in a few seconds. The two currently popular models for GRB progenitors are the coalescence of two compact objects (such as neutron stars or black holes) or collapse of a massive star. An unavoidable consequence of the latter model is that a bright supernovae should accompany the GRB. The emission from this supernova competes with the much brighter afterglow produced by the relativistic shock that gives rise to the GRB itself. Here we present evidence for an unusual light curve for GRB 980326 based on new optical observations. The transient brightened ~3 weeks after the burst to a flux sixty times larger than that extrapolated from the rapid decay seen at early time. Furthermore, the spectrum changed dramatically and became extremely red. We argue that the new source is the underlying supernova. If our hypothesis i...

  19. Constraints on an Optical Afterglow and on Supernova Light Following the Short Burst GRB 050813

    NARCIS (Netherlands)

    Ferrero, P.; Sanchez, S.F.; Kann, D.A.; Klose, S.; Greiner, J.; Gorosabel, J.; Hartmann, D.H.; Henden, A.A.; Møller, P.; Palazzi, E.; Rau, A.; Stecklum, B.; Castro-Tirado, A.J.; Fynbo, J.P.U.; Hjorth, J.; Jakobsson, P.; Kouveliotou, C.; Masetti, N.; Pian, E.; Tanvir, N.R.; Wijers, R.A.M.J.

    2007-01-01

    We report early follow-up observations of the error box of the short burst GRB 050813 using the telescopes at Calar Alto and Observatorio Sierra Nevada, followed by deep VLT FORS2 I-band observations obtained under very good seeing conditions 5.7 and 11.7 days after the event. Neither a fading after

  20. INTEGRAL and XMM-Newton observations of the weak gamma-ray burst GRB 030227

    DEFF Research Database (Denmark)

    Mereghetti, S.; Gotz, D.; Tiengo, A.

    2003-01-01

    We present International Gamma-Ray Astrophysical Laboratory ( INTEGRAL) and XMM-Newton observations of the prompt gamma-ray emission and the X-ray afterglow of GRB 030227, the first gamma-ray burst for which the quick localization obtained with the INTEGRAL Burst Alert System has led to the disco...

  1. GRB off-axis afterglows and the emission from the accompanying supernovae

    Science.gov (United States)

    Kathirgamaraju, Adithan; Barniol Duran, Rodolfo; Giannios, Dimitrios

    2016-09-01

    Gamma-ray burst (GRB) afterglows are likely produced in the shock that is driven as the GRB jet interacts with the external medium. Long-duration GRBs are also associated with powerful supernovae (SNe). We consider the optical and radio afterglows of long GRBs for both blasts viewed along the jet axis (`on-axis' afterglows) and misaligned observes (`off-axis' afterglows). Comparing the optical emission from the afterglow with that of the accompanying SN, using SN 1998bw as an archetype, we find that only a few per cent of afterglows viewed off-axis are brighter than the SN. For observable optical off-axis afterglows, the viewing angle is at most twice the half-opening angle of the GRB jet. Radio off-axis afterglows should be detected with upcoming radio surveys within a few hundred Mpc. We propose that these surveys will act as `radio triggers', and that dedicated radio facilities should follow-up these sources. Follow-ups can unveil the presence of the radio SN remnant, if present. In addition, they can probe the presence of a mildly relativistic component, either associated with the GRB jet or the SN ejecta, expected in these sources.

  2. INTEGRAL and XMM-Newton observations of the weak gamma-ray burst GRB 030227

    DEFF Research Database (Denmark)

    Mereghetti, S.; Gotz, D.; Tiengo, A.

    2003-01-01

    We present International Gamma-Ray Astrophysical Laboratory ( INTEGRAL) and XMM-Newton observations of the prompt gamma-ray emission and the X-ray afterglow of GRB 030227, the first gamma-ray burst for which the quick localization obtained with the INTEGRAL Burst Alert System has led to the disco...

  3. Machine Learning Model of the Swift/BAT Trigger Algorithm for Long GRB Population Studies

    CERN Document Server

    Graff, Philip B; Baker, John G; Sakamoto, Takanori

    2015-01-01

    To draw inferences about gamma-ray burst (GRB) source populations based on Swift observations, it is essential to understand the detection efficiency of the Swift burst alert telescope (BAT). This study considers the problem of modeling the Swift/BAT triggering algorithm for long GRBs, a computationally expensive procedure, and models it using machine learning algorithms. A large sample of simulated GRBs from Lien 2014 is used to train various models: random forests, boosted decision trees (with AdaBoost), support vector machines, and artificial neural networks. The best models have accuracies of $\\gtrsim97\\%$ ($\\lesssim 3\\%$ error), which is a significant improvement on a cut in GRB flux which has an accuracy of $89.6\\%$ ($10.4\\%$ error). These models are then used to measure the detection efficiency of Swift as a function of redshift $z$, which is used to perform Bayesian parameter estimation on the GRB rate distribution. We find a local GRB rate density of $n_0 \\sim 0.48^{+0.41}_{-0.23} \\ {\\rm Gpc}^{-3} {\\...

  4. The redshift and afterglow of the extremely energetic gamma-ray burst GRB 080916C

    CERN Document Server

    Greiner, J.; Kruehler, T.; Kienlin, A.v.; Rau, A.; Sari, R.; Fox, Derek B.; Kawai, N.; Afonso, P.; Ajello, M.; Berger, E.; Cenko, S.B.; Cucchiara, A.; Filgas, R.; Klose, S.; Yoldas, A.Kuepue; Lichti, G.G.; Loew, S.; McBreen, S.; Nagayama, T.; Rossi, A.; Sato, S.; Szokoly, G.; Yoldas, A.; Zhang, X.-L.

    2009-01-01

    The detection of GeV photons from gamma-ray bursts (GRBs) has important consequences for the interpretation and modelling of these most-energetic cosmological explosions. The full exploitation of the high-energy measurements relies, however, on the accurate knowledge of the distance to the events. Here we report on the discovery of the afterglow and subsequent redshift determination of GRB 080916C, the first GRB detected by the Fermi Gamma-Ray Space Telescope with high significance detection of photons at >0.1 GeV. Observations were done with 7-channel imager GROND at the 2.2m MPI/ESO telescope, the SIRIUS instrument at the Nagoya-SAAO 1.4m telescope in South Africa, and the GMOS instrument at Gemini-S. The afterglow photometric redshift of z=4.35+-0.15, based on simultaneous 7-filter observations with the Gamma-Ray Optical and Near-infrared Detector (GROND), places GRB 080916C among the top 5% most distant GRBs, and makes it the most energetic GRB known to date. The detection of GeV photons from such a dista...

  5. Revealing the Jet Structure of Grb 030329 With High Resolution Multicolor Photometry

    Energy Technology Data Exchange (ETDEWEB)

    Gorosabel, Javier; Castro-Tirado, A.J.; Ramirez-Ruiz, E.; Granot, J.; Caon, N.; Cairos, L.M.; Rubio-Herrera, E.; Guziy, S.; de Ugarte Postigo, A.; Jelinek, M.; /IAA,

    2006-03-15

    We present multicolor optical observations of the nearby (z = 0.1685) GRB030329 obtained with the same instrumentation over a time period of 6 hours for a total of an unprecedented 475 quasi-simultaneous B V R observations. The achromatic steepening in the optical, which occurs at t {approx} 0.7 days, provides evidence for a dynamic transition of the source, and can be most readily explained by models in which the GRB ejecta are collimated into a jet. Since the current state-of-the-art modeling of GRB jets is still flawed with uncertainties, we use these data to critically assess some classes of models that have been proposed in the literature. The data, especially the smooth decline rate seen in the optical afterglow, are consistent with a model in which GRB030329 was a homogeneous, sharp-edged jet, viewed near its edge interacting with a uniform external medium, or viewed near its symmetry axis with a stratified wind-like external environment. The lack of short timescale fluctuations in the optical afterglow flux down to the 0.5 per cent level puts stringent constraints on possible small scale angular inhomogeneities within the jet or fluctuations in the external density.

  6. The origin of the early-time optical emission of Swift GRB 080310

    NARCIS (Netherlands)

    Littlejohns, O.M.; Willingale, R.; O'Brien, P.T.; Beardmore, A.P.; Covino, S.; Perley, D.A.; Tanvir, N.R.; Rol, E.; Yuan, F.; Akerlof, C.; D'Avanzo, P.; Bersier, D.F.; Castro-Tirado, A.J.; Christian, P.; Cobb, B.E.; Evans, P.A.; Filippenko, A.V.; Flewelling, H.; Fugazza, D.; Hoversten, E.A.; Kamble, A.P.; Kobayashi, S.; Li, W.; Morgan, A.N.; Mundell, C.G.; Page, K.; Palazzi, E.; Quimby, R.M.; Schulze, S.; Steele, I.A.; de Ugarte Postigo, A.

    2012-01-01

    We present broad-band multiwavelength observations of GRB 080310 at redshift z= 2.43. This burst was bright and long-lived, and unusual in having extensive optical and near-infrared (IR) follow-up during the prompt phase. Using these data we attempt to simultaneously model the gamma-ray, X-ray, opti

  7. A cross-correlation search for intermediate-duration gravitational waves from GRB magnetars

    Science.gov (United States)

    Coyne, Robert

    2015-04-01

    Since the discovery of the afterglow in 1997, the progress made in our understanding of gamma-ray bursts (GRBs) has been spectacular. Yet a direct proof of GRB progenitors is still missing. In the last few years, evidence for a long-lived and sustained central engine in GRBs has mounted. This has called attention to the so-called millisecond-magnetar model, which proposes that a highly magnetized, rapidly-rotating neutron star may exist at the heart of some of these events. The advent of advanced gravitational wave detectors such as LIGO and Virgo may enable us to probe directly, for the first time, the nature of GRB progenitors and their byproducts. In this context, we describe a novel application of a generalized cross-correlation technique optimized for the detection of long-duration gravitational wave signals that may be associated with bar-like deformations of GRB magnetars. The detection of these signals would allow us to answer some of the most intriguing questions on the nature of GRB progenitors, and serve as a starting point for a new class of intermediate-duration gravitational wave searches.

  8. The low-extinction afterglow in the solar-metallicity host galaxy of GRB 110918A

    CERN Document Server

    Elliott, J; Greiner, J; Savaglio, S; E., F Olivares; Rau, A; Postigo, A de Ugarte; Sánchez-Ramírez, R; Wiersema, K; Schady, P; Kann, D A; Filgas, R; Nardini, M; Berger, E; Fox, D; Gorosabel, J; Klose, S; Levan, A; Guelbenzu, A Nicuesa; Rossi, A; Schmidl, S; Sudilovsky, V; Tanvir, N R; Thöne, C C

    2013-01-01

    Galaxies selected through long gamma-ray bursts (GRBs) could be of fundamental importance when mapping the star formation history out to the highest redshifts. Before using them as efficient tools in the early Universe, however, the environmental factors that govern the formation of GRBs need to be understood. Metallicity is theoretically thought to be a fundamental driver in GRB explosions and energetics, but is still, even after more than a decade of extensive studies, not fully understood. This is largely related to two phenomena: a dust-extinction bias, that prevented high-mass and thus likely high-metallicity GRB hosts to be detected in the first place, and a lack of efficient instrumentation, that limited spectroscopic studies including metallicity measurements to the low-redshift end of the GRB host population. The subject of this work is the very energetic GRB 110918A, for which we measure one of the largest host-integrated metallicities, ever, and the highest stellar mass for z<1.9. This presents ...

  9. GROND observations of GRB 160622A/SNR RCW 103/SGR 1617-5103

    Science.gov (United States)

    Schady, P.; Kann, D. A.; Greiner, J.

    2016-06-01

    We observed the field of GRB 160622A/SNR RCW 103/SGR 1617-5103 (Swift trigger 700791; D'Ai et al., GCN #19547. ATel #9180) simultaneously in g'r'i'z'JHK with GROND (Greiner et al. 2008, PASP 120, 405) mounted at the 2.2 m MPG telescope at ESO La Silla Observatory (Chile).

  10. The afterglow and the host galaxy of GRB 011211

    Science.gov (United States)

    Jakobsson, P.; Hjorth, J.; Fynbo, J. P. U.; Gorosabel, J.; Pedersen, K.; Burud, I.; Levan, A.; Kouveliotou, C.; Tanvir, N.; Fruchter, A.; Rhoads, J.; Grav, T.; Hansen, M. W.; Michelsen, R.; Andersen, M. I.; Jensen, B. L.; Pedersen, H.; Thomsen, B.; Weidinger, M.; Bhargavi, S. G.; Cowsik, R.; Pandey, S. B.

    2003-09-01

    We present optical, near-infrared, and X-ray observations of the optical afterglow (OA) of the X-ray rich, long-duration gamma-ray burst GRB 011211. Hubble Space Telescope (HST) data obtained 14, 26, 32, and 59 days after the burst, show the host galaxy to have a morphology that is fairly typical of blue galaxies at high redshift. We measure its magnitude to be R = 24.95 +/- 0.11. We detect a break in the OA R-band light curve which is naturally accounted for by a collimated outflow geometry. By fitting a broken power-law to the data we find a best fit with a break 1.56 +/- 0.02 days after the burst, a pre-break slope of alpha1 = -0.95 +/- 0.02, and a post-break slope of alpha2 = -2.11 +/- 0.07. The UV-optical spectral energy distribution (SED) around 14 hours after the burst is best fit with a power-law with index beta = -0.56 +/- 0.19 reddened by an SMC-like extinction law with a modest AV = 0.08 +/- 0.08 mag. By comparison, from the XMM-Newton X-ray data at around the same time, we find a decay index of alphaX = -1.62 +/- 0.36 and a spectral index of betaX = -1.21+0.10-0.15. Interpolating between the UV-optical and X-ray implies that the cooling frequency is located close to ~ 1016 Hz in the observer frame at the time of the observations. We argue, using the various temporal and spectral indices above, that the most likely afterglow model is that of a jet expanding into an external environment that has a constant mean density rather than a wind-fed density structure. We estimate the electron energy index for this burst to be p ~ 2.3. Based on observations made with the Nordic Optical Telescope, operated on the island of La Palma jointly by Denmark, Finland, Iceland, Norway, and Sweden. Based on observations made with ESO Telescopes at the Paranal Observatory by GRACE under programme ID 69.D-0701. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained from the Data Archive at the Space Telescope Science Institute, which is operated by the

  11. Individual radiation sensitivity (gender, age, genetic disposition). Consequences for radiation protection; Individuelle Strahlenempfindlichkeit (Geschlecht-Alter-genetische Disposition). Konsequenzen fuer den Strahlenschutz?

    Energy Technology Data Exchange (ETDEWEB)

    Streffer, C. [Universitaetsklinikum Essen (Germany)

    2013-07-01

    The effects of ionising radiation on human health is influenced by a number of physiological and molecular biological factors. This is also valid for the causation of stochastic radiation effects especially the causation of cancer. Several epidemiological studies have resulted with respect to the total rate of solid cancers that women are more sensitive than men by a factor of 1.6 to 2.0. For leukaemia this is not the case. The largest studies come from the investigations on the survivors of the atomic bombs in Hiroshima and Nagasaki. But also studies on the population of the Techa River (Southeast Urals) yield such data. The analyses of single cancer localizations come to different results with respect to the dependence on the sex. Secondary cancers after radiotherapy for cancer treatment show also higher rates in women than in men. A similar situation is observed with respect to the dependence of cancer rate on age. The total rate of solid cancers is highest with children and decreases with increasing age. The effects are very different again with single cancer localizations. An especially strong age dependence was observed for thyroid cancer. Increasingly individuals have been found who are especially radiosensitive on the basis of their genetic disposition also with respect to the causation of cancer. Mechanisms and possibilities to trace these individuals are discussed. It is also discussed whether and to which extent these data should have consequences for the practical radiological protection. (orig.)

  12. The dark GRB080207 in an extremely red host and the implications for GRBs in highly obscured environments

    CERN Document Server

    Svensson, K M; Perley, D A; Michalowski, M J; Page, K L; Bloom, J S; Cenko, S B; Hjorth, J; Jakobsson, P; Watson, D; Wheatley, P J

    2011-01-01

    [Abridged] We present comprehensive X-ray, optical, near- and mid-infrared, and sub-mm observations of GRB 080207 and its host galaxy. The afterglow was undetected in the optical and near-IR, implying an optical to X-ray index 2 are at lower metallicity than the sub-mm galaxy population, offering a likely explanation for the dearth of sub-mm detected GRB hosts. However, we also show that the dark GRB hosts are systematically more massive than those hosting optically bright events, perhaps implying that previous host samples are severely biased by the exclusion of dark events.

  13. Chronic reduction of plasma free fatty acid improves mitochondrial function and whole-body insulin sensitivity in obese and type 2 diabetic individuals.

    Science.gov (United States)

    Daniele, Giuseppe; Eldor, Roy; Merovci, Aurora; Clarke, Geoffrey D; Xiong, Juan; Tripathy, Devjit; Taranova, Anna; Abdul-Ghani, Muhammad; DeFronzo, Ralph A

    2014-08-01

    Insulin resistance and dysregulation of free fatty acid (FFA) metabolism are core defects in type 2 diabetic (T2DM) and obese normal glucose tolerant (NGT) individuals. Impaired muscle mitochondrial function (reduced ATP synthesis) also has been described in insulin-resistant T2DM and obese subjects. We examined whether reduction in plasma FFA concentration with acipimox improved ATP synthesis rate and altered reactive oxygen species (ROS) production. Eleven NGT obese and 11 T2DM subjects received 1) OGTT, 2) euglycemic insulin clamp with muscle biopsy, and 3) (1)H-magnetic resonance spectroscopy of tibialis anterior muscle before and after acipimox (250 mg every 6 h for 12 days). ATP synthesis rate and ROS generation were measured in mitochondria isolated from muscle tissue ex vivo with chemoluminescence and fluorescence techniques, respectively. Acipimox 1) markedly reduced the fasting plasma FFA concentration and enhanced suppression of plasma FFA during oral glucose tolerance tests and insulin clamp in obese NGT and T2DM subjects and 2) enhanced insulin-mediated muscle glucose disposal and suppression of hepatic glucose production. The improvement in insulin sensitivity was closely correlated with the decrease in plasma FFA in obese NGT (r = 0.81) and T2DM (r = 0.76) subjects (both P 50% in both obese NGT and T2DM subjects and was strongly correlated with the decrease in plasma FFA and increase in insulin-mediated glucose disposal (both r > 0.70, P < 0.001). Production of ROS did not change after acipimox. Reduction in plasma FFA in obese NGT and T2DM individuals improves mitochondrial ATP synthesis rate, indicating that the mitochondrial defect in insulin-resistant individuals is, at least in part, reversible.

  14. Modeling The GRB Host Galaxy Mass Distribution: Are GRBs Unbiased Tracers of Star Formation?

    Energy Technology Data Exchange (ETDEWEB)

    Kocevski, Daniel; /KIPAC, Menlo Park; West, Andrew A.; /UC, Berkeley, Astron. Dept. /MIT, MKI; Modjaz, Maryam; /UC, Berkeley, Astron. Dept.

    2009-08-03

    We model the mass distribution of long gamma-ray burst (GRB) host galaxies given recent results suggesting that GRBs occur in low metallicity environments. By utilizing measurements of the redshift evolution of the mass-metallicity (M-Z) relationship for galaxies, along with a sharp host metallicity cut-off suggested by Modjaz and collaborators, we estimate an upper limit on the stellar mass of a galaxy that can efficiently produce a GRB as a function of redshift. By employing consistent abundance indicators, we find that sub-solar metallicity cut-offs effectively limit GRBs to low stellar mass spirals and dwarf galaxies at low redshift. At higher redshifts, as the average metallicity of galaxies in the Universe falls, the mass range of galaxies capable of hosting a GRB broadens, with an upper bound approaching the mass of even the largest spiral galaxies. We compare these predicted limits to the growing number of published GRB host masses and find that extremely low metallicity cut-offs of 0.1 to 0.5 Z{sub {circle_dot}} are effectively ruled out by a large number of intermediate mass galaxies at low redshift. A mass function that includes a smooth decrease in the efficiency of producing GRBs in galaxies of metallicity above 12+log(O/H){sub KK04} = 8.7 can, however, accommodate a majority of the measured host galaxy masses. We find that at z {approx} 1, the peak in the observed GRB host mass distribution is inconsistent with the expected peak in the mass of galaxies harboring most of the star formation. This suggests that GRBs are metallicity biased tracers of star formation at low and intermediate redshifts, although our model predicts that this bias should disappear at higher redshifts due to the evolving metallicity content of the universe.

  15. HIGH-ENERGY EMISSION OF GRB 130427A: EVIDENCE FOR INVERSE COMPTON RADIATION

    Energy Technology Data Exchange (ETDEWEB)

    Fan, Yi-Zhong; Zhang, Fu-Wen; He, Hao-Ning; Zhou, Bei; Yang, Rui-Zhi; Jin, Zhi-Ping; Wei, Da-Ming [Key Laboratory of Dark Matter and Space Astronomy, Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008 (China); Tam, P. H. T. [Institute of Astronomy and Department of Physics, National Tsing Hua University, Hsinchu 30013, Taiwan (China); Liang, Yun-Feng, E-mail: yzfan@pmo.ac.cn, E-mail: fwzhang@pmo.ac.cn, E-mail: dmwei@pmo.ac.cn [Department of Physics, Guangxi University, Guangxi 530004 (China)

    2013-10-20

    A nearby superluminous burst GRB 130427A was simultaneously detected by six γ-ray space telescopes (Swift, the Fermi GLAST Burst Monitor (GBM)/Large Area Telescope, Konus-Wind, SPI-ACS/INTEGRAL, AGILE, and RHESSI) and by three RAPTOR full-sky persistent monitors. The isotropic γ-ray energy release is ∼10{sup 54} erg, rendering it the most powerful explosion among gamma-ray bursts (GRBs) with a redshift z ≤ 0.5. The emission above 100 MeV lasted about one day, and four photons are at energies greater than 40 GeV. We show that the count rate of 100 MeV-100 GeV emission may be mainly accounted for by the forward shock synchrotron radiation and the inverse Compton radiation likely dominates at GeV-TeV energies. In particular, an inverse Compton radiation origin is favored for the ∼(95.3, 47.3, 41.4, 38.5, 32) GeV photons arriving at t ∼ (243, 256.3, 610.6, 3409.8, 34366.2) s after the trigger of Fermi-GBM. Interestingly, the external inverse Compton scattering of the prompt emission (the second episode, i.e., t ∼ 120-260 s) by the forward-shock-accelerated electrons is expected to produce a few γ-rays at energies above 10 GeV, while five were detected in the same time interval. A possible unified model for the prompt soft γ-ray, optical, and GeV emission of GRB 130427A, GRB 080319B, and GRB 090902B is outlined. Implications of the null detection of >1 TeV neutrinos from GRB 130427A by IceCube are discussed.

  16. IDENTIFYING THE LOCATION IN THE HOST GALAXY OF THE SHORT GRB 111117A WITH THE CHANDRA SUBARCSECOND POSITION

    Energy Technology Data Exchange (ETDEWEB)

    Sakamoto, T.; Troja, E. [Center for Research and Exploration in Space Science and Technology (CRESST), NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Aoki, K. [Subaru Telescope, National Astronomical Observatory of Japan, 650 North A' ohoku Place, Hilo, HI 96720 (United States); Guiriec, S.; Barthelmy, S. D. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Im, M.; Jeon, Y. [Center for the Exploration of the Origin of the Universe (CEOU), Department of Physics and Astronomy, Seoul National University, Seoul, 151-747 (Korea, Republic of); Leloudas, G.; Malesani, D.; De Ugarte Postigo, A.; Andersen, M. I. [Dark Cosmology Centre, Niels Bohr Institute, University of Copenhagen, Juliane Maries Vej 30, DK-2100 Copenhagen O (Denmark); Melandri, A.; D' Avanzo, P. [INAF-Osservatorio Astronomico di Brera, via Bianchi 46, I-23807 Merate (Italy); Urata, Y. [Institute of Astronomy, National Central University, Chung-Li 32054, Taiwan (China); Xu, D. [Department of Particle Physics and Astronomy, The Weizmann Institute of Science, Rehovot 76100 (Israel); Gorosabel, J.; Sanchez-Ramirez, R. [Instituto de Astrofisica de Andalucia (CSIC), Glorieta de la Astronomia s/n, E-18008 Granada (Spain); Bai, J. [Yunnan Astronomical Observatory, Chinese Academy of Sciences, Kunming, Yunnan Province, 650011 (China); Briggs, M. S. [Center for Space Plasma and Aeronomic Research, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Foley, S. [Max-Planck-Institut fuer extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching (Germany); and others

    2013-03-20

    We present our successful Chandra program designed to identify, with subarcsecond accuracy, the X-ray afterglow of the short GRB 111117A, which was discovered by Swift and Fermi. Thanks to our rapid target of opportunity request, Chandra clearly detected the X-ray afterglow, though no optical afterglow was found in deep optical observations. The host galaxy was clearly detected in the optical and near-infrared band, with the best photometric redshift of z=1.31{sub -0.23}{sup +0.46} (90% confidence), making it one of the highest known short gamma-ray burst (GRB) redshifts. Furthermore, we see an offset of 1.0 {+-} 0.2 arcsec, which corresponds to 8.4 {+-} 1.7 kpc, between the host and the afterglow position. We discuss the importance of using Chandra for obtaining subarcsecond X-ray localizations of short GRB afterglows to study GRB environments.

  17. Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins

    DEFF Research Database (Denmark)

    Salcini, A E; McGlade, J; Pelicci, G

    1994-01-01

    of Grb2 to Shc proteins requires phosphorylation of Shc at Tyr317, which lies within the high affinity binding motif for the Grb2 SH2 domain, pYVNV, where Asn at the +2 position is crucial for complex formation. In vivo, Tyr317 is the major, but not the only, site for Shc phosphorylation, and is the sole...... is implicated in the regulation of Ras, suggesting that Shc is involved in the intracellular transmission of growth signals from activated tyrosine kinases to Ras. Overexpression of Shc proteins in cultured fibroblasts induces a transformed phenotype. We now report that, in vitro, the high affinity binding...... Shc high affinity binding site for Grb2. Mutant Shc proteins with substitution of the Tyr317 by Phe lose the capacity to be highly phosphorylated on tyrosine upon growth factor receptor activation, to bind Grb2 and to induce neoplastic transformation. In contrast, Shc proteins that have an extensive...

  18. A Unified Model for GRB Prompt Emission from Optical to Gamma-Rays; a New Type of Standard Candle

    CERN Document Server

    Guiriec, S; Hartmann, D H; Granot, J; Asano, K; Meszaros, P; Gill, R; Gehrels, N; McEnery, J

    2016-01-01

    The origin of prompt emission from gamma ray bursts remains to be an open question. Correlated prompt optical and gamma-ray emission observed in a handful of GRBs strongly suggests a common emission region, but failure to adequately fit the broadband GRB spectrum prompted the hypothesis of different emission mechanisms for the low- and high-energy radiations. We demonstrate that our multi-component model for GRB gamma-ray prompt emission provides an excellent fit to GRB 110205A from optical to gamma-ray energies. Our results show that the optical and highest gamma-ray emissions have the same spatial and spectral origin, which is different from the bulk of the X- and softest gamma-ray radiation. Finally, our accurate redshift estimate for GRB 110205A demonstrates promise for using GRBs as cosmological standard candles.

  19. Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions

    Directory of Open Access Journals (Sweden)

    Winnie W Leung

    2007-01-01

    Full Text Available Winnie W Leung1, Margaret M McClure1, Larry J Siever1,2, Deanna M Barch3, Philip D Harvey1,21Department of Veterans Affairs, VISN 3 Mental Illness Research, Education, and Clinical Center (MIRECC, Bronx, NY, USA; 2Department of Psychiatry, Mt. Sinai School of Medicine, New York, NY, USA; 3Departments of Psychology and Psychiatry, Washington University, St. Louis, MO, USAAbstract: A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT, an enzyme responsible for the degradation of the catecholamine dopamine (DA, epinephrine, and norepinephrine, is associated with cognitive deficits. However, previous studies have not examined the effects of COMT on context processing, as measured by the AX-CPT, a task hypothesized to be maximally relevant to DA function. 32 individuals who were either healthy, with schizotypal personality disorder, or non-cluster A, personality disorder (OPD were genotyped at the COMT Val158Met locus. Met/Met (n = 6, Val/Met (n = 10, Val/Val (n = 16 individuals were administered a neuropsychological battery, including the AX-CPT and the N-back working memory test. For the AX-CPT, Met/Met demonstrated more AY errors (reflecting good maintenance of context than the other genotypes, who showed equivalent error rates. Val/Val demonstrated disproportionately greater deterioration with increased task difficulty from 0-back to 1-back working memory demands as compared to Met/Met, while Val/Met did not differ from either genotypes. No differences were found on processing speed or verbal working memory. Both context processing and working memory appear related to COMT genotype and the AX-CPT and N-back may be most sensitive to the effects of COMT variation.Keywords: COMT, dopamine, context processing, working memory, schizotypal personality disorder

  20. Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2.

    Directory of Open Access Journals (Sweden)

    Steve P Crampton

    Full Text Available BACKGROUND: THE COMPLEXITY OF WNT SIGNALING LIKELY STEMS FROM TWO SOURCES: multiple pathways emanating from frizzled receptors in response to wnt binding, and modulation of those pathways and target gene responsiveness by context-dependent signals downstream of growth factor and matrix receptors. Both rac1 and c-jun have recently been implicated in wnt signaling, however their upstream activators have not been identified. METHODOLOGY/PRINCIPAL FINDINGS: Here we identify the adapter protein Grb2, which is itself an integrator of multiple signaling pathways, as a modifier of beta-catenin-dependent wnt signaling. Grb2 synergizes with wnt3A, constitutively active (CA LRP6, Dvl2 or CA-beta-catenin to drive a LEF/TCF-responsive reporter, and dominant negative (DN Grb2 or siRNA to Grb2 block wnt3A-mediated reporter activity. MMP9 is a target of beta-catenin-dependent wnt signaling, and an MMP9 promoter reporter is also responsive to signals downstream of Grb2. Both a jnk inhibitor and DN-c-jun block transcriptional activation downstream of Dvl2 and Grb2, as does DN-rac1. Integrin ligation by collagen also synergizes with wnt signaling as does overexpression of Focal Adhesion Kinase (FAK, and this is blocked by DN-Grb2. CONCLUSIONS/SIGNIFICANCE: These data suggest that integrin ligation and FAK activation synergize with wnt signaling through a Grb2-rac-jnk-c-jun pathway, providing a context-dependent mechanism for modulation of wnt signaling.

  1. The high-energy gamma-ray fluence and energy spectrum of GRB 970417a from observations with Milagrito

    CERN Document Server

    Atkins, R; Berley, D; Chen, M L; Coyne, D G; Dingus, B L; Dorfan, D E; Ellsworth, R W; Evans, D; Falcone, A D; Fleysher, L; Fleysher, R; Gisler, G; Sánchez, M M G; Goodman, J A; Haines, T J; Hoffman, C M; Hugenberger, S; Kelley, L A; Klein, S; Leonor, I; McCullough, J F; McEnery, J E; Miller, R S; Mincer, A I; Morales, M F; Némethy, P; Ryan, J M; Samuelson, F W; Shen, B; Shoup, A L; Sinnis, C; Smith, A J; Sullivan, G W; Tümer, T O; Wang, K; Wascko, M O; Westerhoff, S; Williams, D A; Yang, T; Yodh, G B

    2003-01-01

    Evidence of TeV emission from GRB970417a has been previously reported using data from the Milagrito detector. Constraints on the TeV fluence and the energy spectrum are now derived using additional data from a scaler system that recorded the rate of signals from the Milagrito photomultipliers. This analysis shows that if emission from GRB970417a has been observed, it must contain photons with energies above 650 GeV. Some consequences of this observation are discussed.

  2. miR-411-5p inhibits proliferation and metastasis of breast cancer cell via targeting GRB2

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yunda [Department of Gastrointestinal Surgery, First Affiliated Hospital of Xiamen University, Xiamen 361003 (China); State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361102 (China); Xu, Guoxing [Department of Gastrointestinal Surgery, First Affiliated Hospital of Xiamen University, Xiamen 361003 (China); Department of Gastrointestinal Surgery, First Clinical Medical College of Fujian Medical University, Fuzhou 350005 (China); Liu, Gang; Ye, Yongzhi [Department of Gastrointestinal Surgery, First Affiliated Hospital of Xiamen University, Xiamen 361003 (China); Zhang, Chuankai [Department of Gastrointestinal Surgery, First Affiliated Hospital of Xiamen University, Xiamen 361003 (China); State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361102 (China); Fan, Chuannan [State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361102 (China); Wang, Haibin; Cai, Huali; Xiao, Rui [Department of Gastrointestinal Surgery, First Affiliated Hospital of Xiamen University, Xiamen 361003 (China); Department of Gastrointestinal Surgery, First Clinical Medical College of Fujian Medical University, Fuzhou 350005 (China); Huang, Zhengjie, E-mail: huangzhengjie@xmu.edu.cn [Department of Gastrointestinal Surgery, First Affiliated Hospital of Xiamen University, Xiamen 361003 (China); Department of Gastrointestinal Surgery, First Clinical Medical College of Fujian Medical University, Fuzhou 350005 (China); Luo, Qi, E-mail: luoqixmzsh@126.com [Department of Gastrointestinal Surgery, First Affiliated Hospital of Xiamen University, Xiamen 361003 (China); Department of Gastrointestinal Surgery, First Clinical Medical College of Fujian Medical University, Fuzhou 350005 (China)

    2016-08-05

    miR-411-5p (previously called miR-411) is severely involved in human diseases, however, the relationship between miR-411-5p and breast cancer has not been investigated thoroughly. Here, we found that the expression of miR-411-5p was downregulated in breast cancer tissues compared with their matched adjacent non-neoplastic tissues. In addition, the expression of miR-411-5p was also lower in breast cancer cell lines in contrast with MCF-10A. Moreover, we investigated the target and mechanism of miR-411-5p in breast cancer using mimic and inhibitor, and demonstrated the involvement of GRB2 and Ras activation. Ectopic expression of miR-411-5p suppressed the breast cancer cell proliferation, migration and invasion while low expression of miR-411-5p exhibited the opposite effect. Furthermore, GRB2 was demonstrated to be significantly overexpressed in breast cancer tissues compared with normal tissues, and low expression of GRB2 had a longer overall survival compared with high expression of GRB2 in breast cancer. In general, our study shed light on the miR-411-5p related mechanism in the progression of breast cancer and, miR-411-5p/GRB2/Ras axis is potential to be molecular target for breast cancer therapy. - Highlights: • miR-411-5p is downregulated in breast cancer tissues and cell lines. • miR-411-5p inhibits breast cancer cells growth, migration and invasion in vitro. • GRB2 is a direct target of miR-411-5p in breast cancer. • GRB2 is overexpressed in breast cancer and associates with disease outcome. • miR-411-5p suppresses breast cancer progression though GRB2-SOS-Ras pathway.

  3. Improvement of uncorrected visual acuity (UCVA and contrast sensitivity (UCCS with perceptual learning and transcranial random noise stimulation (tRNS in individuals with mild myopia

    Directory of Open Access Journals (Sweden)

    Rebecca eCamilleri

    2014-10-01

    Full Text Available Perceptual learning has been shown to produce an improvement of visual acuity (VA and contrast sensitivity (CS both in subjects with amblyopia and refractive defects such as myopia or presbyopia. Transcranial random noise stimulation (tRNS has proven to be efficacious in accelerating neural plasticity and boosting perceptual learning in healthy participants. In this study we investigated whether a short behavioural training regime using a contrast detection task combined with online tRNS was as effective in improving visual functions in participants with mild myopia compared to a two-month behavioural training regime without tRNS (Camilleri et al., 2014. After two weeks of perceptual training in combination with tRNS, participants showed an improvement of 0.15 LogMAR in uncorrected VA (UCVA that was comparable with that obtained after eight weeks of training with no tRNS, and an improvement in uncorrected CS (UCCS at various spatial frequencies (whereas no UCCS improvement was seen after eight weeks of training with no tRNS. On the other hand, a control group that trained for two weeks without stimulation did not show any significant UCVA or UCCS improvement. These results suggest that the combination of behavioural and neuromodulatory techniques can be fast and efficacious in improving sight in individuals with mild myopia.

  4. Detection of the ultra-high z short GRB 080913 and its implications on progenitors and energy extraction mechanisms

    CERN Document Server

    Pérez-Ramírez, D; Gorosabel, J; Aloy, M A; Guerrero, M A; Osborne, J P; Page, K L; Warwick, R S; Horváth, I; Veres, P; Jelinek, M; Kubánek, P; Guziy, S; Bremer, M; Winters, J M; Castro-Tirado, A J

    2008-01-01

    Aims: We present multiwavelength observations of the most distant gamma-ray burst detected so far GRB 080913 and study whether it can be considered a short-duration GRB and the implications for the progenitor nature and energy extraction mechanisms. Methods: Multiwavelength (X-ray/nIR/millimetre) observations were made between 20.7 hours and ~16.8 days after the event. Results: Whereas a very faint afterglow was seen at the 3.5m CAHA telescope in the nIR, the X-ray afterglow was clearly detected in our XMM-Newton observations. An upper limit is reported in the mm range. At typical redshifts of other bursts, GRB 080913 would be found in the locus of short-duration GRBs on a hardness-duration diagram, thus strengthening its membership of this class. We also report that GRB 080913 shows lower isotropic luminosities than GRB 060121, another likely member of the short-duration class of GRB at z~4.6. Regarding the nature of the progenitor, we find that a NS+BH is slightly preferred over a double NS merger, with the...

  5. The optical identifcation of events with poorly defined locations: The case of the Fermi GBM GRB140801A

    CERN Document Server

    Lipunov, V M; Pruzhinskaya, M V; Postigo, A de Ugarte; Pelassa, V; Tsvetkova, A E; Sokolov, I V; Kann, D A; Xu, Dong; Gorbovskoy, E S; Krushinski, V V; Kornilov, V G; Balanutsa, P V; Boronina, S V; Budnev, N M; Cano, Z; Castro-Tirado, A J; Chazov, V V; Connaughton, V; Delvaux, C; Frederiks, D D; Fynbo, J F U; Gabovich, A V; Goldstein, A; Greiner, J; Gress, O A; Ivanov, K I; Jakobsson, P; Klose, S; Knust, F; Komarova, V N; Konstantinov, E; Krylov, A V; Kuvshinov, D A; Kuznetsov, A S; Lipunova, G V; Moskvitin, A S; Pal'shin, V D; Pandey, S B; Poleshchuk, V A; Schmidl, S; Sergienko, Yu P; Sinyakov, E V; Schulze, S; Sokolov, V V; Sokolova, T N; Sparre, M; Thone, C C; Tlatov, A G; Tyurina, N V; Ulanov, M V; Yazev, S A; Yurkov, V V

    2015-01-01

    We report the early discovery of the optical afterglow of gamma-ray burst (GRB) 140801A in the 137 deg$^2$ 3-$\\sigma$ error-box of the Fermi Gamma-ray Burst Monitor (GBM). MASTER is the only observatory that automatically react to all Fermi alerts. GRB 140801A is one of the few GRBs whose optical counterpart was discovered solely from its GBM localization. The optical afterglow of GRB 140801A was found by MASTER Global Robotic Net 53 sec after receiving the alert, making it the fastest optical detection of a GRB from a GBM error-box. Spectroscopy obtained with the 10.4-m Gran Telescopio Canarias and the 6-m BTA of SAO RAS reveals a redshift of $z=1.32$. We performed optical and near-infrared photometry of GRB 140801A using different telescopes with apertures ranging from 0.4-m to 10.4-m. GRB 140801A is a typical burst in many ways. The rest-frame bolometric isotropic energy release and peak energy of the burst is $E_\\mathrm{iso} = 5.54_{-0.24}^{+0.26} \\times 10^{52}$ erg and $E_\\mathrm{p, rest}\\simeq280$ keV,...

  6. GRB 980425 host: [C II], [O I], and CO lines reveal recent enhancement of star formation due to atomic gas inflow

    DEFF Research Database (Denmark)

    Michałowski, M. J.; Castro Cerón, J. M.; Wardlow, J. L.;

    2016-01-01

    in the closest galaxy hosting a GRB (980425). Methods. We obtained the first ever far-infrared (FIR) line observations of a GRB host, namely Herschel/PACS resolved [C ii] 158 μm and [O i] 63 μm spectroscopy, and an APEX/SHeFI CO(2-1) line detection and ALMA CO(1-0) observations of the GRB 980425 host. Results...

  7. 高焦虑敏感个体情绪面孔注意偏向特征%The characteristics of attentional bias in high anxiety sensitivity individuals

    Institute of Scientific and Technical Information of China (English)

    蒋怀滨; 张斌; 林珂; 李淑清; 詹薇

    2016-01-01

    Objective To investigate the characteristics and mechanisms of attentional bias in anxiety sensitivity individuals.Methods By using Anxiety Sensitivity Index (ASI),23 participants were included in the high score group and 20 participants were included in the low score group.Then,2 (between-subject factor:the high and low score group) ×2 (within-subject factor:the positive and negative picture) mixed design experiments were adopted.Emotional faces picture pairs were chosen as stimuli.Picture pairs were presented 100 ms in experiment 1 and 1 250 ms in experiment 2.Dot-probe task was adopted to inspect the attentional bias and the response time and correct rate were recorded.Results Experiment 1 implied the main effect of type of pictures was found in mixed design experiments(F(1,41)=4.40,P<0.05).The reaction time of two groups in positive pictures was greater than zero((12.22±30.24) ms vs (10.07±21.55) ms).It showed input effect to positive pictures.An input effect due to the reaction time of the high score group was greater than zero to negative pictures((4.81± 17.88)ms),while the low score group tended to avoid the negative pictures ((-6.81 ±21.33) ms).Experiment 2 implied positive score was not significant between two groups (F(1,41) =0.29,P>0.05).And positive score showed the attentional bias to some certain extent.Significant outcome was found by negative score between two groups (F(1,41) =6.41,P<0.05).It implied that the high score group tended to avoid the negative pictures and the low score group had the tendency of input effect.Conclusion At the initial stage of attention,anxiety sensitivity individuals had the attentional bias to negative emotional faces and avoidance in the late stage of attention.It suggests that the attentional bias of anxiety sensitivity individuals may have an important effect on the development of the mental disorders.%目的 探讨焦虑敏感个体注意偏向特点及机制.方法 使用大学生焦虑

  8. Concluding Remarks: The Current Status and Future Prospects for GRB Astronomy

    Science.gov (United States)

    Gehrels, Neil

    2009-01-01

    We are in a remarkable period of discovery in GRB astronomy. The current satellites including Swift, Fermi. AGILE and INTEGRAL are detecting and observing bursts of all varieties. Increasing capabilities for follow-up observations on the ground and in space are leading to rapid and deep coverage across the electromagnetic spectrum, The future will see continued operation of the current experiments and with future missions like SVOM plus possible rni_Ssions like JANUS and EXIST. An exciting expansion of capabilities is occurring in areas of gravitational waves and neutrinos that could open new windows on the GRB phenomenon. Increased IR capabilities on the ground and with missions like JWST will enable further exploration of high redshift bursts. The future is bright.

  9. Modeling the early afterglow in the short and hard GRB 090510

    CERN Document Server

    Fraija, Nissim; Veres, Peter; Duran, Rodolfo Barniol

    2016-01-01

    The bright, short and hard GRB 090510 was detected by all instruments aboard Fermi and Swift satellites. The multiwavelength observations of this burst presented similar features with the Fermi-LAT-detected gamma-ray bursts. In the framework of the external shock model of early afterglow, a leptonic scenario that evolves in a homogeneous medium is proposed to revisit GRB 090510 and explain the multiwavelength light curve observations presented in this burst. These observations are consistent with the evolution of a jet before and after the jet break. The long-lasting LAT, X-ray and optical fluxes are explained in the synchrotron emission from the adiabatic forward shock. Synchrotron self-Compton emission from the reverse shock is consistent with the bright LAT peak provided that progenitor environment is entrained with strong magnetic fields. It could provide compelling evidence of magnetic field amplification in the neutron star merger.

  10. The Interpretation of the Multi-wavelength Afterglow Emission of Short GRB 140903A

    Science.gov (United States)

    Zhang, Shuai; Jin, Zhi-Ping; Wang, Yuan-Zhu; Wei, Da-Ming

    2017-01-01

    GRB 140903A, a short duration γ-ray burst (SGRB) detected by Swift, is characterized by its long-lasting radio emission among SGRBs. In addition to the ∼ {10}6 s radio afterglow emission, the afterglow of GRB 140903A displays a plateau from 103 s to 7× {10}3 {{s}} in the X-rays. In this work, we attribute the X-ray plateau to the energy injection into the decelerating blast wave and then model the later radio/optical/X-ray afterglow emission within the standard fireball afterglow model. The afterglow emission has been well reproduced with reasonable physical parameters, including a jet half-opening angle of ∼0.05.

  11. Modeling the Early Afterglow in the Short and Hard GRB 090510

    Science.gov (United States)

    Fraija, N.; Lee, W. H.; Veres, P.; Barniol Duran, R.

    2016-11-01

    The bright, short, and hard GRB 090510 was detected by all instruments aboard the Fermi and Swift satellites. The multiwavelength observations of this burst presented similar features to the Fermi-LAT-detected gamma-ray bursts. In the framework of the external shock model of early afterglow, a leptonic scenario that evolves in a homogeneous medium is proposed to revisit GRB 090510 and explain the multiwavelength light curve observations presented in this burst. These observations are consistent with the evolution of a jet before and after the jet break. The long-lasting LAT, X-ray, and optical fluxes are explained in the synchrotron emission from the adiabatic forward shock. Synchrotron self-Compton emission from the reverse shock is consistent with the bright LAT peak provided that the progenitor environment is entrained with strong magnetic fields. It could provide compelling evidence of magnetic field amplification in the neutron star merger.

  12. Fermi Observations of high-energy gamma-ray emissions from GRB 080916C

    CERN Document Server

    Abdo, A A; Arimoto, M; Asano, K; Atwood, W B; Axelsson, M; Baldini, L; Ballet, J; Band, D L; Barbiellini, Guido; Baring, Matthew G; Bastieri, Denis; Battelino, M; Baughman, B M; Bechtol, K; Bellardi, F; Bellazzini, R; Berenji, B; Bhat, P N; Bissaldi, E; Blandford, R D; Bloom, Elliott D; Bogaert, G; Bogart, J R; Bonamente, E; Bonnell, J; Borgland, A W; Bouvier, A; Bregeon, J; Brez, A; Briggs, M S; Brigida, M; Bruel, P; Burnett, Thompson H; Burrows, David N; Busetto, Giovanni; Caliandro, G A; Cameron, R A; Caraveo, P A; Casandjian, J M; Ceccanti, M; Cecchi, C; Celotti, Annalisa; Charles, E; Chekhtman, A; Cheung, C.C.Teddy; Chiang, J; Ciprini, S; Claus, R; Cohen-Tanugi, Johann; Cominsky, Lynn R; Connaughton, V; Conrad, J; Costamante, L; Cutini, S; DeKlotz, M; Dermer, C D; De Angelis, Alessandro; de Palma, F; Digel, S W; Dingus, B L; do Couto e Silva, Eduardo; Drell, P S; Dubois, R; Dumora, D; Edmonds, Y; Evans, P A; Fabiani, D; Farnier, C; Favuzzi, C; Finke, Justin D; Fishman, G; Focke, W B; Frailis, M; Fukazawa, Y; Funk, S; Fusco, P; Gargano, F; Gasparrini, D; Gehrels, N; Germani, S; Giebels, B; Giglietto, N; Giommi, P; Giordano, F; Glanzman, Thomas Lynn; Godfrey, Gary L; Goldstein, A; Granot, J; Greiner, J; Grenier, I A; Grondin, M H; Grove, J.Eric; Guillemot, L; Guiriec, S; Haller, G; Hanabata, Y; Harding, Alice K; Hayashida, M; Hays, Elizabeth A; Hernando Morata, J A; Hoover, A; Hughes, R E; Johannesson, G; Johnson, A S; Johnson, R P; Johnson, T J; Johnson, W N; Kamae, Tsuneyoshi; Katagiri, H; Kataoka, J; Kavelaars, A; Kawai, N; Kelly, H; Kennea, J; Kerr, M; Kippen, R M; Knodlseder, J; Kocevski, D; Kocian, M L; Komin, N; Kouveliotou, C; Kuehn, Frederick Gabriel Ivar; Kuss, Michael; Lande, J; Landriu, D; Larsson, S; Latronico, L; Lavalley, C; Lee, B; Lee, S H; Lemoine-Goumard, M; Lichti, G G; Longo, F; Loparco, F; Lott, B; Lovellette, M N; Lubrano, Pasquale; Madejski, G M; Makeev, A; Marangelli, B; Mazziotta, M N; McBreen, Sheila; McEnery, J E; McGlynn, S; Meegan, C; Miszaros, P; Meurer, C; Michelson, P F; Minuti, M; Mirizzi, N; Mitthumsiri, W; Mizuno, T; Moiseev, A A; Monte, C; Monzani, M E; Moretti, E; Morselli, A; Moskalenko, Igor Vladimirovich; Murgia, Simona; Nakamori, T; Nelson, D; Nolan, P L; Norris, J P; Nuss, E; Ohno, M; Ohsugi, Takashi; Okumura, Akira; Omodei, N; Orlando, E; Ormes, J F; Ozaki, M; Paciesas, W S; Paneque, D; Panetta, J H; Parent, D; Pelassa, V; Pepe, M; Perri, M; Pesce-Rollins, M; Petrosian, Vahe; Pinchera, M; Piron, F; Porter, Troy A; Preece, R; Rainr, S; Ramirez-Ruiz, E; Rando, R; Rapposelli, E; Razzano, M; Razzaque, Soebur; Rea, N; Reimer, A; Reimer, O; Reposeur, Thierry; Reyes, Luis C; Ritz, S; Rochester, L S; Rodriguez, A Y; Roth, M; Ryde, F; Sadrozinski, H F W; Sanchez, D; Sander, A; Parkinson, P.M.Saz; Scargle, J D; Schalk, T L; Segal, K N; Sgro, C; Shimokawabe, T; Siskind, E J; Smith, D A; Smith, P D; Spandre, G; Spinelli, P; Stamatikos, M; Starck, Jean-Luc; Stecker, Floyd William; Steinle, H; Stephens, T E; Strickman, M S; Suson, Daniel J; Tagliaferri, G.; Tajima, Hiroyasu; Takahashi, H; Takahashi, T; Tanaka, T; Tenze, A; Thayer, J B; Thayer, J G; Thompson, D J; Tibaldo, L; Torres, Diego F; Tosti, G; Tramacere, A; Turri, M; Tuvi, S; Usher, T L; van der Horst, A J; Vigiani, L; Vilchez, N; Vitale, V; von Kienlin, A; Waite, A P; Williams, D A; Wilson-Hodge, C; Winer, B L; Wood, K S; Wu, X F; Yamazaki, R; Ylinen, T; Ziegler, M

    2009-01-01

    Gamma-ray bursts (GRBs) are highly energetic explosions signaling the death of massive stars in distant galaxies. The Gamma-ray Burst Monitor and Large Area Telescope onboard the Fermi Observatory together record GRBs over a broad energy range spanning about 7 decades of gammaray energy. In September 2008, Fermi observed the exceptionally luminous GRB 080916C, with the largest apparent energy release yet measured. The high-energy gamma rays are observed to start later and persist longer than the lower energy photons. A simple spectral form fits the entire GRB spectrum, providing strong constraints on emission models. The known distance of the burst enables placing lower limits on the bulk Lorentz factor of the outflow and on the quantum gravity mass.

  13. Extremely narrow spectrum of GRB110920A: further evidence for localised, subphotospheric dissipation

    CERN Document Server

    Iyyani, S; Ahlgren, B; Burgess, J M; Larsson, J; Pe'er, A; Lundman, C; Axelsson, M; McGlynn, S

    2015-01-01

    Much evidence points towards that the photosphere in the relativistic outflow in GRBs plays an important role in shaping the observed MeV spectrum. However, it is unclear whether the spectrum is fully produced by the photosphere or whether a substantial part of the spectrum is added by processes far above the photosphere. Here we make a detailed study of the $\\gamma-$ray emission from single pulse GRB110920A which has a spectrum that becomes extremely narrow towards the end of the burst. We show that the emission can be interpreted as Comptonisation of thermal photons by cold electrons in an unmagnetised outflow at an optical depth of $\\tau \\sim 20$. The electrons receive their energy by a local dissipation occurring close to the saturation radius. The main spectral component of GRB110920A and its evolution is thus, in this interpretation, fully explained by the emission from the photosphere including localised dissipation at high optical depths.

  14. The luminosity and stellar mass functions of GRB host galaxies: Insight into the metallicity bias

    CERN Document Server

    Trenti, Michele; Jimenez, Raul

    2014-01-01

    [Abridged] Long-Duration Gamma-Ray Bursts (GRBs) are powerful probes of the star formation history of the Universe, but the correlation between the two depends on the highly debated presence and strength of a metallicity bias. To investigate this correlation, we use a phenomenological model that successfully describes star formation rates, luminosities and stellar masses of star forming galaxies, and apply it to GRB production. We predict the comoving GRB rate and luminosities/stellar masses of host galaxies depending on the presence (or absence) of a metallicity bias, highlighting that apparent conflicts among previous studies might disappear following a comprehensive data-model comparison. We conclude that: (1) Our best fitting model includes a moderate metallicity bias, broadly consistent with the large majority of the long-duration GRBs in metal-poor environments originating from a collapsar (~83%), but with a secondary contribution from a metal-independent production channel, such as binary evolution; (2...

  15. Concluding Remarks: The Current Status and Future Prospects for GRB Astronomy

    Science.gov (United States)

    Gehrels, Neil

    2009-01-01

    We are in a remarkable period of discovery in GRB astronomy. The current satellites including Swift, Fermi. AGILE and INTEGRAL are detecting and observing bursts of all varieties. Increasing capabilities for follow-up observations on the ground and in space are leading to rapid and deep coverage across the electromagnetic spectrum, The future will see continued operation of the current experiments and with future missions like SVOM plus possible rni_Ssions like JANUS and EXIST. An exciting expansion of capabilities is occurring in areas of gravitational waves and neutrinos that could open new windows on the GRB phenomenon. Increased IR capabilities on the ground and with missions like JWST will enable further exploration of high redshift bursts. The future is bright.

  16. Constraining the Structure of GRB Jets Through the Log N - Log S Distribution

    Energy Technology Data Exchange (ETDEWEB)

    Guetta, D.

    2005-01-05

    A general formalism is developed for calculating the luminosity function and the expected number N of observed GRBs above a peak photon flux S for an arbitrary GRB jet structure. This formalism directly provides the true GRB rate for any jet model, instead of first calculating the GRB rate assuming isotropic emission and then introducing a ''correction factor'' to account for effects of the GRB jet structure, as was done in previous works. We apply it to the uniform jet (UJ) and universal structured jet (USJ) models for the structure of GRB jets and perform fits to the observed log N-log S distribution from the GUSBAD catalog which contains 2204 BATSE bursts. We allow for a scatter in the peak luminosity L for a given jet half-opening angle {theta}{sub j} (viewing angle {theta}{sub obs}) in the UJ (USJ) model, which is implied by observations. A core angle {theta}{sub c} and an outer edge at {theta}{sub max} are introduced for the structured jet, and a finite range of opening angles {theta}{sub min} {le} {theta}{sub j} {le} {theta}{sub max} is assumed for the uniform jets. The efficiency for producing {gamma}-rays, {epsilon}{sub {gamma}}, and the energy per solid angle in the jet, {epsilon}, are allowed to vary with {theta}{sub j} ({theta}{sub obs}) in the UJ (USJ) model, {epsilon}{sub {gamma}} {proportional_to} {theta}{sup -b} and {epsilon} {proportional_to} {theta}{sup -a}. We find that a single power-law luminosity function provides a good fit to the data. Such a luminosity function arises naturally in the USJ model, while in the UJ model it implies a power-law probability distribution for {theta}{sub j}, P({theta}{sub j}) {proportional_to} {theta}{sub j}{sup -1}. . The value of q cannot be directly determined from the fit to the observed log N-log S distribution, and an additional assumption on the value of a or b is required. Alternatively, an independent estimate of the true GRB rate would enable one to determine a, b and q. The implied

  17. Hadronic Models for the Extra Spectral Component in the short GRB 090510

    CERN Document Server

    Asano, Katsuaki; Mészáros, Peter

    2009-01-01

    A short gamma-ray burst GRB 090510 detected by {\\it Fermi} shows an extra spectral component between 10 MeV and 30 GeV, an addition to a more usual low-energy ($<10$ MeV) Band component. In general, such an extra component could originate from accelerated protons. In particular, inverse Compton emission from secondary electron-positron pairs and proton synchrotron emission are competitive models for reproducing the hard spectrum of the extra component in GRB 090510. Here, using Monte Carlo simulations, we test the hadronic scenarios against the observed properties. To reproduce the extra component around GeV with these models, the proton injection isotropic-equivalent luminosity is required to be larger than $10^{55}$ erg$ / $s. Such large proton luminosities are a challenge for the hadronic models.

  18. Discovery of a Transient Absorption Edge in the X-ray Spectrum of GRB 990705

    CERN Document Server

    Amati, L; Vietri, M; in 't Zand, J J M; Soffitta, P; Costa, E; Del Sordo, S; Pian, E; Piro, L; Antonelli, L A; Dal Fiume, D; Feroci, M; Gandolfi, G; Guidorzi, C; Heise, J; Kuulkers, E; Masetti, N; Montanari, E; Nicastro, L; Orlandini, M; Palazzi, E

    2000-01-01

    We report the discovery of a transient equivalent hydrogen column density with an absorption edge at ~3.8 kiloelectron volts in the spectrum of the prompt x-ray emission of gamma-ray burst (GRB) 990705. This feature can be satisfactorily modeled with a photoelectric absorption by a medium located at a redshift of ~0.86 and with an iron abundance of ~75 times the solar one. The transient behavior is attributed to the strong ionization produced in the circumburst medium by the GRB photons. The high iron abundance points to the existence of a burst environment enriched by a supernova along the line of sight. The supernova explosion is estimated to have occurred about 10 years before the burst. Our results agree with models in which GRBs originate from the collapse of very massive stars and are preceded by a supernova event

  19. Soft X-ray Observation of the Prompt Emission of GRB100418A

    CERN Document Server

    Imatani, Ritsuko; Nakahira, Satoshi; Kimura, Masashi; Sakamoto, Takanori; Arimoto, Makoto; Morooka, Yoshitaka; Yonetoku, Daisuke; Kawai, Nobuyuki; Tsunemi, Hiroshi

    2015-01-01

    We have observed the prompt emission of GRB100418A, from its beginning by the MAXI/SSC (0.7-7 keV) on board the International Space Station followed by the Swift/XRT (0.3-10 keV) observation. The light curve can be fitted by a combination of a power law component and an exponential component (decay constant is $31.6\\pm 1.6$). The X-ray spectrum is well expressed by the Band function with $E_{\\rm p}\\leq$8.3 keV. This is the brightest GRB showing a very low value of $E_{\\rm p}$. It is also consistent with the Yonetoku-relation ($E_{\\rm p}$-$L_{\\rm p}$) while it is not clear with the Amati-relation ($E_{\\rm p}$-$E_{\\rm iso}$).

  20. 生长因子受体结合蛋白7(Grb7)研究进展%Research progresses on growth factor receptor-bound 7

    Institute of Scientific and Technical Information of China (English)

    张丹; 高友鹤

    2011-01-01

    Growth factor receptor-bound 7(Grb7), a member of Grb7 protein family, has three distinct functional regions: a lot of proline amino acids exist in its N terminal, and the mesial district has such similar amino acids sequence as that of MIG-IO protein from Caenorhabditis elegans, and a SH2 domain in its C terminal. With these different domain, Grb7 protein plays distinct roles in cellular signaling pathway. And if we know more about the biological function acted by different domains of Grb7 protein, people may be benefited from treatment of patients with high expression of Grb7 protein.%Grb7蛋白是Grb7蛋白家族的成员之一,该蛋白有3种结构区域:N末端富含脯氨酸,中间结构域与线虫(Caenorhabditis elegans)的MIG-10蛋白有着很高的同源性,C末端为SHY.结构域.Grb7通过3种结构域尤其是SH2结构域,参与细胞各种信号传导途径.研究其不同结构域在肿瘤细胞中所发挥的作用,将对Grb7高表达的肿瘤治疗产生重要影响.

  1. The Ultra-long GRB 111209A. II. Prompt to Afterglow and Afterglow Properties

    Science.gov (United States)

    Stratta, G.; Gendre, B.; Atteia, J. L.; Boër, M.; Coward, D. M.; De Pasquale, M.; Howell, E.; Klotz, A.; Oates, S.; Piro, L.

    2013-12-01

    The "ultra-long" gamma-ray burst GRB 111209A at redshift z = 0.677 is the longest GRB ever observed thus far, with a rest frame prompt emission duration of ~4 hr. In order to explain the burst exceptional longevity, a low-metallicity blue supergiant progenitor was invoked. In this article we further constrain the phenomenology and progenitor properties of this peculiar GRB by performing a multiband temporal and spectral analysis of both the prompt and the afterglow emission. We use proprietary and publicly available data from Swift, Konus WIND, XMM-Newton, and TAROT, as well as from other ground-based optical and radio telescopes. We find some peculiar properties that are possibly connected to the exceptional nature of this burst, namely: (1) an unprecedented large optical delay of 410 ± 50 s between the peak time in gamma-rays and the peak time in the optical of a marked multiwavelength flare; (2) multiwavelength prompt emission spectral modeling requires a certain amount of dust in the circumburst environment. The dust produces a rest frame visual extinction of AV = 0.3-1.5 mag, and may undergo destruction at late times; and (3) we detect the presence of a hard spectral extra power-law component at the end of the X-ray steep steep decay phase and before the start of the X-ray afterglow, which has never been revealed thus far in past GRBs. The optical afterglow shows more usual properties; it has a flux power-law decay with an index of 1.6 ± 0.1 and a late rebrightening feature observed at ~1.1 the day after the first Burst Alert Telescope trigger. We discuss our findings in the context of several possible interpretations that have been given thus far of the complex multiband GRB phenomenology and propose a binary channel formation for the blue supergiant progenitor.

  2. The ultra-long GRB 111209A. II. Prompt to afterglow and afterglow properties

    Energy Technology Data Exchange (ETDEWEB)

    Stratta, G. [Osservatorio Astronomico di Roma (OAR/INAF), via Frascati 33, I-00040 Monte Porzio Catone (Italy); Gendre, B.; Boër, M. [ARTEMIS, UMR 7250 (CNRS/OCA/UNS), boulevard de l' Observatoire, BP 4229, F-06304 Nice Cedex (France); Atteia, J. L. [Université de Toulouse, UPS-OMP, IRAP, F-31400 Toulouse (France); Coward, D. M.; Howell, E. [School of Physics, University of Western Australia (UWA), Crawley, WA 6009 (Australia); De Pasquale, M.; Oates, S. [Mullard Space Science Laboratory (MSSL), University College London, Holmbury St. Mary, Dorking, Surrey RH5 6NT (United Kingdom); Klotz, A. [IRAP, 14, avenue Edouard Belin, F-31400 Toulouse (France); Piro, L. [Istituto di Astrofisica e Planetologia Spaziali di Roma (IAPS/INAF), via fosso del cavaliere 100, I-00133 Roma (Italy)

    2013-12-10

    The 'ultra-long' gamma-ray burst GRB 111209A at redshift z = 0.677 is the longest GRB ever observed thus far, with a rest frame prompt emission duration of ∼4 hr. In order to explain the burst exceptional longevity, a low-metallicity blue supergiant progenitor was invoked. In this article we further constrain the phenomenology and progenitor properties of this peculiar GRB by performing a multiband temporal and spectral analysis of both the prompt and the afterglow emission. We use proprietary and publicly available data from Swift, Konus WIND, XMM-Newton, and TAROT, as well as from other ground-based optical and radio telescopes. We find some peculiar properties that are possibly connected to the exceptional nature of this burst, namely: (1) an unprecedented large optical delay of 410 ± 50 s between the peak time in gamma-rays and the peak time in the optical of a marked multiwavelength flare; (2) multiwavelength prompt emission spectral modeling requires a certain amount of dust in the circumburst environment. The dust produces a rest frame visual extinction of A{sub V} = 0.3-1.5 mag, and may undergo destruction at late times; and (3) we detect the presence of a hard spectral extra power-law component at the end of the X-ray steep steep decay phase and before the start of the X-ray afterglow, which has never been revealed thus far in past GRBs. The optical afterglow shows more usual properties; it has a flux power-law decay with an index of 1.6 ± 0.1 and a late rebrightening feature observed at ∼1.1 the day after the first Burst Alert Telescope trigger. We discuss our findings in the context of several possible interpretations that have been given thus far of the complex multiband GRB phenomenology and propose a binary channel formation for the blue supergiant progenitor.

  3. GRB 080407: An Ultra-long Burst Discovered by the IPN

    Science.gov (United States)

    Cummings, J; Barthelmy, S.; Gehrels, N.; Krimm, H.; Palmer, D.; Palshin, V.; Hurley, K.; Goldsten, J.; Mitrofanov, I. G.; Boynton, W.; vonKienlln, A.; Feroci, M.; Aptekar, R.; Frederiks, D.; Golenetskli, S.; Mazets, E.; Svinkin, D.; Golovin, D.; Litvak, M. L.; Sanin, A. B.; Fellows, C.; Harshman, K.; Starr, R.; Rau, A.; Zhang, X.

    2012-01-01

    We present observations of the extremely long GRB 080704 obtained with the instruments of the Interplanetary Network (IPN). The observations reveal two distinct emission episodes, separated by a approx.1500 s long period of quiescence. The total burst duration is about 2100 s. We compare the temporal and spectral characteristics of this burst with those obtained for other ultra-long GRBs and discuss these characteristics in the context of different models.

  4. GRB 080407: an ultra-long burst discovered by the IPN

    CERN Document Server

    Pal'shin, V; Goldsten, J; Mitrofanov, I G; Boynton, W; von Kienlin, A; Cummings, J; Feroci, M; Aptekar, R; Frederiks, D; Golenetskii, S; Mazets, E; Svinkin, D; Golovin, D; Litvak, M L; Sanin, A B; Fellows, C; Harshman, K; Starr, R; Rau, A; Savchenko, V; Zhang, X; Barthelmy, S; Gehrels, N; Krimm, H; Palmer, D; Del Monte, E; Marisaldi, M

    2013-01-01

    We present observations of the extremely long GRB 080704 obtained with the instruments of the Interplanetary Network (IPN). The observations reveal two distinct emission episodes, separated by a ~1500 s long period of quiescence. The total burst duration is about 2100 s. We compare the temporal and spectral characteristics of this burst with those obtained for other ultra-long GRBs and discuss these characteristics in the context of different models.

  5. Important Property of GRB Pulse: Power-Law Indices of Time Properties on Energy

    Indian Academy of Sciences (India)

    Zhao-Yang Peng

    2014-09-01

    The dependence of pulse temporal properties (pulse width, pulse rise width and pulse decay width) on energy is power-law function. Some correlated relationships between the power-law indices of the pulse time properties on energy and the spectral lags, relative spectral lags, spectral parameters of band function, and photon flux using a well-separated long-duration -ray burst (GRB) pulse sample is demonstrated here. We argue that the curvature effect can explain the correlated properties.

  6. Analysis of the Prompt Optical Emission of the Naked-Eye GRB 080319B

    CERN Document Server

    Bartolini, C; Guarnieri, A; Piccioni, A; Beskin, G; Bondar, S; Karpov, S; Molinari, E

    2009-01-01

    We present the observed/intrinsic optical parameters and the variability analysis of the Naked-Eye Burst, GRB 080319B, observed by the TORTORA wide-field optical monitoring system. The event is extreme not only in observed properties but also intrinsically: it is the most luminous event ever recorded at optical wavelengths. The temporal properties suggest short-lived periodic activities of the internal engine. This is the fastest optically variable source detected at cosmological distances.

  7. VizieR Online Data Catalog: GRB list (1990-2014) (Ruggeri+, 2016)

    Science.gov (United States)

    Ruggeri, A. C.; Capozziello, S.

    2017-08-01

    To investigate the potentialities of the SKA related to the GRB detections in radio band, we need a good instrumental probability, so that we present here a useful repository of all GRBs taken by several catalogues. The thesis is available at: http://www.fedoa.unina.it/10538/1/RuggeriAlanCosimo_27.pdf The paper is available at: http://adsabs.harvard.edu/abs/2016Ap%26SS.361..279R (1 data file).

  8. Evidence for Dust Destruction from the Early-time Colour Change of GRB 120119A

    CERN Document Server

    Morgan, Adam N; Cenko, S B; Bloom, J S; Cucchiara, A; Richards, J W; Filippenko, A V; Haislip, J B; LaCluyze, A; Corsi, A; Melandri, A; Cobb, B E; Gomboc, A; Horesh, A; James, B; Li, W; Mundell, C G; Reichart, D E; Steele, I

    2013-01-01

    We present broadband observations and analysis of Swift gamma-ray burst (GRB) 120119A. Our early-time afterglow detections began under 15 s after the burst in the host frame (redshift z = 1.73), and they yield constraints on the burst energetics and local environment. Late-time afterglow observations of the burst show evidence for a moderate column of dust (A_V ~ 1.1 mag) similar to, but statistically distinct from, dust seen along Small Magellanic Cloud sightlines. Deep late-time observations reveal a dusty, rapidly star-forming host galaxy. Most notably, our early-time observations exhibit a significant red-to-blue colour change in the first ~200 s after the trigger at levels heretofore unseen in GRB afterglows. This colour change, which is coincident with the final phases of the prompt emission, is a hallmark prediction of the photodestruction of dust in GRB afterglows. We test whether dust-destruction signatures are significantly distinct from other sources of colour change, namely a change in the intrins...

  9. The GRB Redshift Distribution: Implications for Abundance Evolution, Star Formation, and Cosmology

    CERN Document Server

    Wei, Jun-Jie; Melia, Fulvio; Wei, Da-Ming; Feng, Long-Long

    2013-01-01

    It has been claimed that the \\emph{Swift} long gamma-ray bursts (LGRBs) do not trace the star formation history (SFH) in $\\Lambda$CDM. In this paper, we confirm that the latest \\emph{Swift} sample of GRBs reveals an increasing evolution in the GRB rate relative to the star formation rate (SFR) at high redshifts. One may eliminate the observed discrepancy between the GRB rate and the SFR by assuming a modest evolution, parameterized as $(1+z)^{0.5}$---an effect that perhaps implies a cosmic evolution in metallicity. However, we find a relatively higher metallicity cut of $Z=0.68Z_{\\odot}$ than was seen in previous studies, which suggested that LGRBs occur preferentially in metal poor environments, i.e., $Z\\sim0.1-0.3Z_{\\odot}$. Here, we use a simple power-law approximation to the high-\\emph{z} ($\\ga 3.8$) SFH, i.e., $R_{\\rm SF}\\propto[(1+z)/4.8]^{\\alpha}$, to examine how the high-\\emph{z} SFR may be impacted by a possible abundance evolution in the \\emph{Swift} GRB sample. For an expansion history consistent w...

  10. Simultaneous optical/gamma-ray observations of GRB 121217's prompt emission

    CERN Document Server

    Elliott, J; Schmidl, S; Greiner, J; Gruber, D; Oates, S; Kobayashi, S; Zhang, B; Cummings, J R; Filgas, R; Gehrels, N; Grupe, D; Kann, D A; Klose, S; Krühler, T; Guelbenzu, A Nicuesa; Rau, A; Rossi, A; Siegel, M; Schady, P; Sudilovsky, V; Tanga, M; Varela, K

    2013-01-01

    Since the advent of the Swift satellite it has been possible to obtain precise localisations of GRB positions of sub-arcsec accuracy within seconds, facilitating ground-based robotic telescopes to automatically slew to the target within seconds. This has yielded a plethora of observational data for the afterglow phase of the GRB, but the quantity of data (<2 keV) covering the initial prompt emission still remains small. Only in a handful of cases has it been possible obtain simultaneous coverage of the prompt emission in a multi-wavelength regime (gamma-ray to optical), as a result of: observing the field by chance prior to the GRB (e.g. 080319B/naked-eye burst), long-prompt emission (e.g., 080928, 110205A) or triggered on a pre-cursor (e.g., 041219A, 050820A, 061121). This small selection of bursts have shown both correlated and uncorrelated gamma-ray and optical light curve behaviour, and the multi-wavelength emission mechanism remains far from resolved (i.e. single population synchrotron self-Component,...

  11. Lorentz factor - Beaming corrected energy/luminosity correlations and GRB central engine models

    Science.gov (United States)

    Yi, Shuang-Xi; Lei, Wei-Hua; Zhang, Bing; Dai, Zi-Gao; Wu, Xue-Feng; Liang, En-Wei

    2017-03-01

    We work on a GRB sample whose initial Lorentz factors (Γ0) are constrained by the afterglow onset method and the jet opening angles (θj) are determined by the jet break time. We confirm the Γ0-Eγ,iso correlation by Liang et al. (2010), and the Γ0-Lγ,iso correlation by Lü et al. (2012). Furthermore, we find correlations between Γ0 and the beaming corrected γ-ray energy (Eγ) and mean γ-ray luminosity (Lγ). By also including the kinetic energy of the afterglow, we find rough correlations (with larger scatter) between Γ0 and the total (γ-ray plus kinetic) energy and the total mean luminosity, both for isotropic values and beaming corrected values: these correlations allow us to test the data with GRB central engine models. Limiting our sample to the GRBs that likely have a black hole central engine, we compare the data with theoretical predictions of two types of jet launching mechanisms from BHs, i.e. the non-magnetized ν ν bar -annihilation mechanism, and the strongly magnetized Blandford-Znajek (BZ) mechanism. We find that the data are more consistent with the latter mechanism, and discuss the implications of our findings for GRB jet composition.

  12. Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes.

    Science.gov (United States)

    Patrick, Michael S; Oda, Hiroyo; Hayakawa, Kunihiro; Sato, Yoshinori; Eshima, Koji; Kirikae, Teruo; Iemura, Shun-Ichiro; Shirai, Mutsunori; Abe, Takaya; Natsume, Tohru; Sasazuki, Takehiko; Suzuki, Harumi

    2009-09-22

    T cells develop in the thymus through positive and negative selection, which are responsible for shaping the T cell receptor (TCR) repertoire. To elucidate the molecular mechanisms involved in selection remains an area of intense interest. Here, we identified and characterized a gene product Gasp (Grb2-associating protein, also called Themis) that is critically required for positive selection. Gasp is a cytosolic protein with no known functional motifs that is expressed only in T cells, especially immature CD4/CD8 double positive (DP) thymocytes. In the absence of Gasp, differentiation of both CD4 and CD8 single positive cells in the thymus was severely inhibited, whereas all other TCR-induced events such as beta-selection, negative selection, peripheral activation, and homeostatic proliferation were unaffected. We found that Gasp constitutively associates with Grb2 via its N-terminal Src homology 3 domain, suggesting that Gasp acts as a thymocyte-specific adaptor for Grb2 or regulates Ras signaling in DP thymocytes. Collectively, we have described a gene called Gasp that is critical for positive selection.

  13. The radiative efficiency of relativistic jet and wind: A case study of GRB 070110

    CERN Document Server

    Du, Shuang; Zhong, Shu-Qing; Liang, En-Wei

    2016-01-01

    A rapidly spinning, strongly magnetized neutron star is invoked as the central engine for some Gamma-ray bursts (GRBs), especially, the $"$internal plateau$"$ feature of X-ray afterglow. However, for these $"$internal plateau$"$ GRBs, how to produce their prompt emission remains an open question. Two different physical process have been proposed in the literature, (1) a new-born neutron star is surrounded by a hyper-accreting and neutrino cooling disk, the GRB jet can be powered by neutrino annihilation aligning the spin axis; (2) a differentially rotating millisecond pulsar was formed due to different angular velocity between the interior core and outer shell parts of the neutron star, which can power an episodic GRB jet. In this paper, by analyzing the data of one peculiar GRB 070110 (with internal plateau), we try to test which model being favored. By deriving the physical parameters of magnetar with observational data, the parameter regime for initial period ($P_{0\\rm }$) and surface polar cap magnetic fi...

  14. GRB 091024A and the nature of ultra-long gamma-ray bursts

    Energy Technology Data Exchange (ETDEWEB)

    Virgili, F. J.; Mundell, C. G.; Harrison, R.; Kobayashi, S.; Steele, I. A.; Mottram, C. J.; Clay, N. R. [Astrophysics Research Institute, Liverpool John Moores University, Liverpool, L3 5RF (United Kingdom); Pal' shin, V. [Ioffe Physical Technical Institute, St. Petersburg 194021 (Russian Federation); Guidorzi, C. [Department of Physics and Earth Sciences, University of Ferrara, Via Saragat, 1, I-44122 Ferrara (Italy); Margutti, R.; Chornock, R. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Melandri, A. [INAF/Brera Astronomical Observatory, via Bianchi 46, I-23807 Merate (Italy); Henden, A. [AAVSO, 49 Bay State Road, Cambridge, MA 02138 (United States); Updike, A. C. [Department of Chemistry and Physics, Roger Williams University, Bristol, RI 02809 (United States); Cenko, S. B. [Department of Astronomy, University of California, Berkeley, CA 94720-3411 (United States); Tanvir, N. R. [Department of Physics and Astronomy, University of Leicester, University Road, Leicester LE1 7RH (United Kingdom); Cucchiara, A. [Department of Astronomy and Astrophysics, UCO/Lick Observatory, University of California, 1156 High Street, Santa Cruz, CA 95064 (United States); Gomboc, A. [Faculty of Mathematics and Physics, University of Ljubljana, Jadranska 19, 1000 Ljubljana (Slovenia); Levan, A. [Department of Physics, University of Warwick, Coventry CV4 7AL (United Kingdom); Cano, Z., E-mail: F.J.Virgili@ljmu.ac.uk [Centre for Astrophysics and Cosmology, Science Institute, University of Iceland, 107 Reykjavik (Iceland); and others

    2013-11-20

    We present a broadband study of gamma-ray burst (GRB) 091024A within the context of other ultra-long-duration GRBs. An unusually long burst detected by Konus-Wind (KW), Swift, and Fermi, GRB 091024A has prompt emission episodes covering ∼1300 s, accompanied by bright and highly structured optical emission captured by various rapid-response facilities, including the 2 m autonomous robotic Faulkes North and Liverpool Telescopes, KAIT, S-LOTIS, and the Sonoita Research Observatory. We also observed the burst with 8 and 10 m class telescopes and determine the redshift to be z = 1.0924 ± 0.0004. We find no correlation between the optical and γ-ray peaks and interpret the optical light curve as being of external origin, caused by the reverse and forward shock of a highly magnetized jet (R{sub B} ≈ 100-200). Low-level emission is detected throughout the near-background quiescent period between the first two emission episodes of the KW data, suggesting continued central-engine activity; we discuss the implications of this ongoing emission and its impact on the afterglow evolution and predictions. We summarize the varied sample of historical GRBs with exceptionally long durations in gamma-rays (≳1000 s) and discuss the likelihood of these events being from a separate population; we suggest ultra-long GRBs represent the tail of the duration distribution of the long GRB population.

  15. Swift observations of GRB 060614: an anomalous burst with a well behaved afterglow

    CERN Document Server

    Mangano, V; Malesani, D; Troja, E; Chincarini, G; Zhang, B; La Parola, V; Brown, P J; Burrows, D N; Campana, S; Capalbi, M; Cusumano, G; Della Valle, M; Gehrels, N; Giommi, P; Grupe, D; Guidorzi, C; Mineo, T; Moretti, A; Osborne, J P; Pandey, S B; Perri, M; Romano, P; Roming, P W A; Tagliaferri, G

    2007-01-01

    GRB 060614 is a remarkable GRB observed by Swift with puzzling properties, which challenge current progenitor models. The lack of any bright SN down to very strict limits and the vanishing spectral lags are typical of short GRBs, strikingly at odds with the long (102s) duration of this event. Here we present spectral and temporal analysis of the Swift observations. We show that the burst presents standard optical, UV and X-ray afterglows. An achromatic break is observed simultaneously in optical and X-rays, at a time consistent with the break in the R-band light curve measured by the VLT. The achromatic behaviour and the consistent post-break decay slopes make GRB 060614 one of the best examples of a jet break for a Swift burst. The optical, UV and X-rays afterglow light curves have also an earlier break at ~30 ks. In the optical, there is strong spectral evolution around this break, suggesting the passage of a break frequency through the optical/UV band. The very blue spectrum at early times and the trend in...

  16. Observations of the Naked-Eye GRB 080319B: Implications of Nature's Brightest Explosion

    CERN Document Server

    Bloom, J S; Li, W; Butler, N R; Miller, A A; Kocevski, D; Kann, D A; Foley, R J; Chen, H -W; Filippenko, A V; Starr, D L; Macomber, B; Prochaska, J X; Chornock, R; Poznanski, D; Klose, S

    2008-01-01

    The first gamma-ray burst (GRB) confirmed to be bright enough to be seen with the naked eye, GRB 080319B, allowed for exquisite follow-up across the electromagnetic spectrum. We present our detailed optical and infrared observations of the afterglow, consisting of over 5000 images starting 122 s after the GRB trigger, in concert with our own analysis of the Swift UVOT, BAT, and XRT data. The event is extreme not only in observed properties but intrinsically: it was the most luminous ever recorded at optical wavelengths and had an exceedingly high isotropic-equivalent energy release in gamma-rays. At early times, the afterglow evolution is broadly consistent with being reverse-shock dominated, then is subsumed by a forward shock at around 1000 s. Analysis of the forward shock suggests that the remarkable energetics of this burst may be owed largely to extreme collimation. The spectral energy distribution, spanning from ultraviolet through near-infrared, shows no evidence for a significant amount of dust extinc...

  17. Analysing afterglows using integral field spectroscopy: GRB 060605, the first practical example

    CERN Document Server

    Ferrero, Patrizia; Kann, David Alexander; Savaglio, Sandra; Palazzi, Eliana; Maiorano, Elisabetta; Böhm, Petra; Schulze, Steve; Grupe, Dirk; Oates, Samantha R; Sánchez, Sebastián F; Amati, Lorenzo; Greiner, Jochen; Hjorth, Jens; Malesani, Daniele; Barthelmy, Scott D; Gorosabel, Javier; Masetti, Nicola; Roth, Martin M

    2008-01-01

    GRB 060605 was a long and relatively faint gamma-ray burst detected by \\emph{Swift}/BAT with a duration of about 20 sec. Its afterglow could be observed with \\emph{Swift}/XRT for nearly 1 day while \\emph{Swift}/UVOT could detect the afterglow during the first 6 hours after the event. Here, we report on integral field spectroscopy of its afterglow performed with PMAS/PPak mounted at the Calar Alto 3.5 m telescope. In addition, we report on a detailed analysis of XRT and UVOT data and on the results of deep late-time VLT observations, which reveal the GRB host galaxy. We find that the burst occured at a redshift of $z$=3.773, possibly associated with a faint, $R_C=26.4 \\pm 0.3$ host. Based on the optical and X-ray data we deduce information on the SED of the afterglow, the position of the cooling frequency in the SED, the nature of the circumburst environment, its collimation factor, and its energetics. We find that the GRB fireball was expanding into a constant-density medium and that the explosion was collima...

  18. The Ultimate Light Curve of SN 1998bw/GRB 980425

    CERN Document Server

    Clocchiatti, Alejandro; Covarrubias, Ricardo; Candia, Pablo

    2011-01-01

    We present multicolor light curves of SN 1998bw which appeared in ESO184-G82 in close temporal and spacial association with GRB 980425. They are based on observations done at Cerro Tololo Inter-American Observatory and data from the literature. The CTIO photometry reaches ~86 days after the GRB in $U$ and ~160 days after the GRB in BV(RI)_C. The observations in U extend by about 30 days the previously known coverage, and determine the slope of the early exponential tail. We calibrate a large set of local standards in common with those of previous studies and use them to transform published observations of the SN to our realization of the standard photometric system. We show that the photometry from different sources merges smoothly and provide a unified set of 300 observations of the SN in five bands. Using the extensive set of spectra in public domain we compute extinction and K corrections, and build quasi-bolometric unreddened rest frame light curves. We provide low degree piecewise spline fits to these li...

  19. The Fast and Faint SN 2010bh Associated with GRB 100316D

    CERN Document Server

    Bufano, Filomena; Sollerman, Jesper; Benetti, Stefano; Pignata, Giuliano; Valenti, Stefano; Covino, Stefano; D'Avanzo, Paolo; Malesani, Daniele; Cappellaro, Enrico; Della Valle, Massimo; Fynbo, Johan; Hjorth, Jens; Mazzali, Paolo A; Reichart, Daniel E; Starling, Rhaana L C; Turatto, Massimo; Vergani, Susanna D; Wiersema, Klass; Amati, Lorenzo; Bersier, David; Campana, Sergio; Cano, Zach; Castro-Tirado, Alberto J; Chincarini, Guido; D'Elia, Valerio; Postigo, Antonio de Ugarte; Deng, Jinsong; Ferrero, Patrizia; Filippenko, Alexei V; Goldoni, Paolo; Gorosabel, Javier; Greiner, Jochen; Hammer, Francois; Jakobsson, Pall; Kaper, Lex; Kawabata, Koji S; Klose, Sylvio; Levan, Andrew J; Maeda, Keiichi; Masetti, Nicola; Milvang-Jensen, Bo; Mirabel, Felix I; Moller, Palle; Nomoto, Kenichi; Palazzi, Eliana; Piranomonte, Silvia; Salvaterra, Ruben; Stratta, Giulia; Tagliaferri, Gianpiero; Tanaka, Masaomi; Wijers, Ralph A M J

    2011-01-01

    We present the spectroscopic and photometric evolution of the nearby (redshift 0.059) spectroscopically confirmed Type Ic supernova, SN 2010bh, associated with a soft, long-duration gamma-ray burst (X-ray flash) GRB 100316D. Intensive follow-up observations of SN 2010bh were performed at the ESO Very Large Telescope (VLT), using the X-shooter and FORS2 instruments. Owing to the detailed temporal coverage and the extended wavelength range (300-2500 nm), we obtained an unprecedentedly rich spectral sequence among the hypernovae, making SN 2010bh one of the best studied representatives of this SN class. We find that SN 2010bh has a more rapid rise to maximum brightness (8.0+/-1.0 days) and a fainter absolute peak luminosity (L(bol)~3e42 ergs) than previously observed SN events associated with GRBs. Our estimate of the ejected (56)Ni mass is 0.12+/-0.02 Msun. From the broad spectral features we measure large expansion velocities, higher than those of SNe 1998bw (GRB 980425) and 2006aj (GRB 060218). The light-curv...

  20. The host galaxy of GRB 011121: Morphology and Spectral Energy Distribution

    CERN Document Server

    Yoldas, A K; Greiner, J; Pierini, D; Pian, E; Rau, A; Yoldas, Aybuke Kupcu; Salvato, Mara; Greiner, Jochen; Pierini, Daniele; Pian, Elena; Rau, Arne

    2006-01-01

    (Abridged) We present a detailed study of the host galaxy of GRB 011121 (at z = 0.36) based on high-resolution imaging in 5 broad-band, optical and near-infrared filters with HST and VLT/ISAAC. The surface brightness profile of this galaxy is best fitted by a Sersic law with index ~ 2 - 2.5 and a rather large effective radius (~ 7.5 kpc). Both the morphological analysis and the F450W - F702W colour image suggest that the host galaxy of GRB 011121 is either a disk-system with a rather small bulge, or one hosting a central, dust-enshrouded starburst. Hence, we modeled the integrated spectral energy distribution of this galaxy by combining stellar population and radiative transfer models, assuming properties representative of nearby starburst or normal star-forming, Sbc-like galaxies. A range of plausible fitting solutions indicates that the host galaxy of GRB 011121 has a stellar mass of 3.1 - 6.9 x10^9 Msun, stellar populations with a maximum age ranging from 0.4 to 2 Gyr, and a metallicity ranging from 1 to 2...