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  1. Energy-transfer processes in Er3+-doped and Er3+,Pr3+-codoped ZBLAN glasses

    NARCIS (Netherlands)

    Golding, P.S.; Jackson, S.D.; King, T.A.; Pollnau, Markus

    2000-01-01

    We present a detailed characterization of energy transfer processes in Er3+-doped and Er3+,Pr3+-codoped ZBLAN bulk glasses. For several Er3+ (0.25–8.75 mol%) and Pr3+ (0.25–1.55 mol%) concentrations, we investigate energy transfer upconversion (ETU) and cross relaxation in Er3+ as well as energy

  2. An ER activity profile including ER, PR, Bcl-2 and IGF-IR may have potential as selection criterion for letrozole or tamoxifen treatment of patients with advanced breast cancer

    DEFF Research Database (Denmark)

    Henriksen, Katrine L; Rasmussen, Birgitte B; Lykkesfeldt, Anne E

    2009-01-01

    microarrays from formalin fixed paraffin embedded primary tumor material from a subgroup of patients (9.4%), who have participated in the international, randomized, phase III clinical trial PO25 comparing letrozole with tamoxifen in 907 patients with advanced breast cancer. The expression levels of ER...

  3. A CLINICAL STUDY ON CARCINOMA BREAST IN RELATION TO ER AND PR STATUS

    Directory of Open Access Journals (Sweden)

    Ramanaiah

    2015-09-01

    Full Text Available INTRODUCTION : Breast carcinoma is the most common malignant tumor and the leading cause of death in women worldwide 1 . It accounts for 15 % of all cancer deaths 2 . According to the World Health Organisation (WHO, approximately 70% of breast cancers occur in women with none of the known risk factors. Only about 5% of breast cancers are inherited. Various protocols are in use for the assessment of prognosis, and also to assist further management of these cases. Of various parameters, expression of hormonereceptors Estrogen receptor (ER and Progesterone receptor (PR ar e significant AIMS AND OBJECTIVES : To study the occurrence of ER and PR status in breast cancer patients attending S.V.R.R.G.G. Hospital. To correlate the expression of prognostic factors like age at presentation menarche, menopause, parity, tumor size, number of lymph nodes, metastasis histology, grading with ER and PR status. MATERIALS AND METHODS : This clinic opathological study of carcinoma breast was carried out in patients admitted to SVRRGG Hospital, Tirupati during the period from September 2011 to August 2013 after obtaining approval from scientific committee and ethical committee .Forty cases of breast carcinoma were taken into study. The clinical study done by interviewing, detailed examination and subjecting to relevant investigations and surgeries depending upon the stage of the disease. Excised specimen is sent for Histopathological examination in 10% formaline Reports of light microscopy (Hematoxilin and Eosin and immunohistochemistry on tumor histology including MBR (Modified Bloom Richardson grading and Estrogen and Progesterone status is analysed. CONCLUSION: In conclusion, ER and PR status correlates well with histopathological grading and other clinico - pathological parameters. Higher grade is associated with ER PR negativity. Hence. Immunohistochemical assessment of ER and PR status should be incorporated as a routine investigation. This along with

  4. Photon Cascade Emission through Energy Transfer in Pr3+ and Er3+ Codoped System

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Energy transfer processes in Pr3+ and Er3+-codoped CaAl12O 19 crystal from 12 to 290 K were studied. Energy transfer from Pr3+ t o Er3+ ions in this system was observed. The transfer can partially conve rt the 1 S0 UV fluorescence of Pr3+ into green emission of the characteristic of Er3+. The efficiency of the energy transfer was estimat ed based of the spectroscopic data. The temperature dependence on the transfer was also discussed.

  5. Association between AgNORs and Immunohistochemical Expression of ER, PR, HER2/neu, and p53 in Breast Carcinoma

    Directory of Open Access Journals (Sweden)

    Hussain Gadelkarim Ahmed

    2011-01-01

    Full Text Available Settings. Despite the limited diagnostic utility of AgNORs (argyrophilic nucleolar organiser region-associated proteins for individual breast lesions, AgNOR analysis bears a significant potential for characterizing cell proliferative activity of breast lesions. Methodology. The present study investigated the relationship between mean AgNORs count and immunohistochemical expression of ER, PR, HER2/neu, and p53 in breast carcinoma in serial paraffin sections from 137 breast carcinomas. Twenty control cases of benign breast lesions were included. Results. Mean AgNOR counts correlated significantly inversely with hormone estrogen receptors (ER, Progesterone receptors (PR, and p53 immunohistochemical expression, denoting values of 0.05, 0.01, and 0.001, respectively. No significant correlation was found between mean AgNOR counts and HER2/neu, =0.9. Mean AgNOR count was significantly higher in grade II tumor cells. We conclude that mean AgNOR counts correlate with ER, PR, and P53 tumor markers in breast carcinomas. Conclusion. We recommend the use of mean AgNOR count for accurate reporting of breast carcinomas, as well as prediction of ER, PR, and P53 in routine paraffin sections.

  6. Familial CJD associated PrP mutants within transmembrane region induced Ctm-PrP retention in ER and triggered apoptosis by ER stress in SH-SY5Y cells.

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    Xin Wang

    Full Text Available BACKGROUND: Genetic prion diseases are linked to point and inserted mutations in the prion protein (PrP gene that are presumed to favor conversion of the cellular isoform of PrP (PrP(C to the pathogenic one (PrP(Sc. The pathogenic mechanisms and the subcellular sites of the conversion are not completely understood. Here we introduce several PRNP gene mutations (such as, PrP-KDEL, PrP-3AV, PrP-A117V, PrP-G114V, PrP-P102L and PrP-E200K into the cultured cells in order to explore the pathogenic mechanism of familial prion disease. METHODOLOGY/PRINCIPAL FINDINGS: To address the roles of aberrant retention of PrP in endoplasmic reticulum (ER, the recombinant plasmids expressing full-length human PrP tailed with an ER signal peptide at the COOH-terminal (PrP-KDEL and PrP with three amino acids exchange in transmembrane region (PrP-3AV were constructed. In the preparations of transient transfections, 18-kD COOH-terminal proteolytic resistant fragments (Ctm-PrP were detected in the cells expressing PrP-KDEL and PrP-3AV. Analyses of the cell viabilities in the presences of tunicamycin and brefeldin A revealed that expressions of PrP-KDEL and PrP-3AV sensitized the transfected cells to ER stress stimuli. Western blots and RT-PCR identified the clear alternations of ER stress associated events in the cells expressing PrP-KDEL and PrP-3AV that induced ER mediated apoptosis by CHOP and caspase-12 apoptosis pathway. Moreover, several familial CJD related PrP mutants were transiently introduced into the cultured cells. Only the mutants within the transmembrane region (G114V and A117V induced the formation of Ctm-PrP and caused the ER stress, while the mutants outside the transmembrane region (P102L and E200K failed. CONCLUSIONS/SIGNIFICANCE: The data indicate that the retention of PrP in ER through formation of Ctm-PrP results in ER stress and cell apoptosis. The cytopathic activities caused by different familial CJD associated PrP mutants may vary, among them

  7. ER/PR Status of the Originating Cell of ER-Negative Breast Cancer

    Science.gov (United States)

    2009-04-01

    levels. Therefore, the best ER BAC clon available at this time cannot express an However, while we were in the process of starting to make TVA...knock-in, we found the following surprise result that provides an alternati We have also created a transgenic line expressing tva from the whey acidic

  8. The Clinical Significance of PR, ER, NF-κB, and TNF-α in Breast Cancer

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    Xian-Long Zhou

    2014-01-01

    Full Text Available Objectives. To investigate the expression of estrogen (ER, progesterone receptors (PR, nuclear factor-κB (NF-κB, and tumor necrosis factor-α (TNF-α in human breast cancer (BC, and the correlation of these four parameters with clinicopathological features of BC. Methods and Results. We performed an immunohistochemical SABC method for the identification of ER, PR, NF-κB, and TNF-α expression in 112 patients with primary BC. The total positive expression rate of ER, PR, NF-κB, and TNF-α was 67%, 76%, 84%, and 94%, respectively. The expressions of ER and PR were correlated with tumor grade, TNM stage, and lymph node metastasis (P<0.01, resp., but not with age, tumor size, histological subtype, age at menarche, menopause status, number of pregnancies, number of deliveries, and family history of cancer. Expressions of ER and PR were both correlated with NF-κB and TNF-α expression (P<0.05, resp.. Moreover, there was significant correlation between ER and PR (P<0.0001 as well as between NF-κB and TNF-α expression (P<0.05. Conclusion. PR and ER are highly expressed, with significant correlation with NF-κB and TNF-α expression in breast cancer. The important roles of ER and PR in invasion and metastasis of breast cancer are probably associated with NF-κB and TNF-α expression.

  9. CLINICAL STUDY OF CORRELATION BETWEEN ESTROGEN RECEPTOR (ER AND PROGESTERONE RECEPTOR (PR STATUS AND PATIENT CHARACTERISTICS IN CARCINOMA BREAST

    Directory of Open Access Journals (Sweden)

    Kiran Kumar

    2016-03-01

    Full Text Available BACKGROUND AND INTRODUCTION Breast carcinoma is the first among women of all races and Hispanic origin populations; most common carcinoma in women and account for 25% of all female cancers, which is more than twice the prevalence of cancer in women at any other site. Recent information suggests globally breast carcinoma is the second leading cause of cancer related death and is the most common cancer among women excluding the non-melanoma skin cancer. Estrogen and Progesterone play a central role in regulating growth kinetics of a variety of epithelial lining like in breast and endometrium and are powerful predictive markers in carcinoma of breast. AIMS AND OBJECTIVES To study the correlation between ER and PR status and patient characteristics like age of patient, menarche, menopause, parity, tumour size, lymph node status and tumour grade in carcinoma breast patient. MATERIALS AND METHODS Forty patients were included in this study who were admitted with breast carcinoma, the patient characteristics are correlated with ER and PR status studied by immunohistochemistry. This study was done over the period from October 2013 to September 2015. RESULTS Patients with both ER/PR positive are better differentiated, low grade, small sized tumours and with less chance of lymph node metastasis. Progesterone receptor negative status is associated with lymph node metastasis independent of other patient characteristics. Grade 3 and 4 tumours showed lower level of Estrogen and Progesterone receptors irrespective of age. CONCLUSION ER/PR positive group were better differentiated, showed better prognosis with hormonal therapy. They were less aggressive, low lymph node metastasis when compared with patients with either of the receptors negative or both the receptors negative. Hence immunohistochemistry is a must as it provides valuable prognostic, predictive and therapeutic information.

  10. Photon Cascade Emission through Energy Transfer in Pr3+and Er3+Codoped System

    Institute of Scientific and Technical Information of China (English)

    王笑军; 黄世华; 等

    2002-01-01

    Energy transfer processes in Pr3+-codoped CaAl12O19crystal from 12 to 290K were studied.Energy transfer from Pr3+toEr3+ions in this system was observed,The transfer can partially convert the 1S0UVfluorescence of Pr3+into green emission of the characteristic of Er3+,The efficiency of the energy transfer was estimated based of the spectroscopic data,The temperature dependence on the transfer was also discussed.

  11. Effect of neoadjuvant chemotherapy on breast cancer phenotype, ER/PR and HER2 expression - Implications for the practising oncologist.

    Science.gov (United States)

    Gahlaut, Renu; Bennett, Aneliese; Fatayer, Hiba; Dall, Barbara J; Sharma, Nisha; Velikova, Galina; Perren, Tim; Dodwell, David; Lansdown, Mark; Shaaban, Abeer M

    2016-06-01

    To assess the effect of neoadjuvant chemotherapy (NACT) on breast cancer characteristics, hormone receptors and human epidermal growth factor receptor 2 (HER2) expression and whether testing should be repeated on residual tumours. Patients with primary operable breast cancer who received NACT at a single United Kingdom tertiary referral centre were included. Tumour type, grade (including details of mitotic grade, tubule formation and pleomorphism), oestrogen receptor (ER), progesterone receptor (PR) and HER2 status were compared between pre-treatment and post-treatment residual samples using tissue microarrays. A control group of paired core and excision tumours from patients who did not receive NACT was also assessed. Two hundred forty-six cases and 113 controls were included. Pathological complete response (path CR) was achieved in 21.5% of patients. In those patients failing to achieve a path CR, a change in the histological type was noted in 29 out of 178 cases (16.3%, pnegative to positive status for ER and from positive to negative status for HER2. Further alterations in expression levels were also noted. Minimal changes in the low ER/PR expressors and the HER2 2+ tumours were found in the control group. Significant changes in tumour morphology, grade, hormone receptors and HER2 status occur following NACT. We recommend testing on residual invasive carcinoma. A switch from negative to positive status warrants offering endocrine/trastuzumab-based therapy to this group of patients. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR.

    Science.gov (United States)

    Yamamoto, Yo-hei; Kimura, Taiji; Momohara, Shuku; Takeuchi, Masato; Tani, Tokio; Kimata, Yukio; Kadokura, Hiroshi; Kohno, Kenji

    2010-01-01

    Cytosolic Hsc70/Hsp70 are known to contribute to the endoplasmic reticulum (ER)-associated degradation of membrane proteins. However, at least in mammalian cells, its partner ER-localized J-protein for this cellular event has not been identified. Here we propose that this missing protein is DNAJB12. Protease protection assay and immunofluorescence study revealed that DNAJB12 is an ER-localized single membrane-spanning protein carrying a J-domain facing the cytosol. Using co-immunoprecipitation assay, we found that DNAJB12 is able to bind Hsc70 and thus can recruit Hsc70 to the ER membrane. Remarkably, cellular overexpression of DNAJB12 accelerated the degradation of misfolded membrane proteins including cystic fibrosis transmembrane conductance regulator (CFTR), but not a misfolded luminal protein. The DNAJB12-dependent degradation of CFTR was compromised by a proteasome inhibitor, lactacystin, suggesting that this process requires the ubiquitin-proteasome system. Conversely, knockdown of DNAJB12 expression attenuated the degradation of CFTR. Thus, DNAJB12 is a novel mammalian ER-localized J-protein that plays a vital role in the quality control of membrane proteins.

  13. Relationship between expression of ER, PR, Her-2, Ki-67 and neoadjuvant chemotherapy effect in breast cancer

    Institute of Scientific and Technical Information of China (English)

    Junping Xu; Hongsheng Yu

    2014-01-01

    Objective: The purpose of the study was to investigate the relationship between the expression of estrogen re-ceptor (ER), progestogen receptor (PR), human epidermal growth factor receptor (Her-2), Ki-67 and the ef ect of neoadjuvant chemotherapy in breast cancer. Methods:The expression of ER, PR, Her-2 and Ki-67 in 45 breast cancers which received neoadjuvant chemotherapy was detected by immunohistochemistry. Results:The ef ective rates in ER negative and PR negative groups were higher than those in ER positive and PR positive groups (83.3%vs 59. 4%, 82.4%vs 60.6%). There was no significant dif erence of the ef ective rate between Her-2 overexpressed group and Her-2 non-overexpressed group (81.8%vs 64.1%), and the same thing happened between Ki-67 negative group and Ki-67 positive group (67.7%vs 63.2%). Conclusion:In the patients with breast cancer, ER, PR negative ones were more sensitive to neoadjuvant chemotherapy. These patients may get more benefits from chemotherapy. ER, PR could be feasible markers for predicting the ef ective rate of neoadjuvant chemotherapy.

  14. Progesterone (PR), oestrogen (ER-α and ER-β) and oxytocin (OTR) gene expression in the oviduct and uterus of pregnant and non-pregnant bitches.

    Science.gov (United States)

    Derussi, A A P; de Souza, R W A; Volpato, R; Guaitolini, C R F; Ackermann, C L; Taffarel, M O; Cardoso, G S; Dal-Pai-Silva, M; Lopes, M D

    2012-12-01

    The aim was to assess hormone receptor gene expression in the oviduct and uterus during canine pregnancy. Nineteen pregnant bitches divided into four groups were ovariohysterectomized (OVH) at either day 8, 12, 21 or 60 of pregnancy, and five non-pregnant females underwent OVH 12 days after the pre-ovulatory Luteinizant Hormone (LH) surge and served as controls. RT-qPCR for progesterone (PR), oestrogen (ER-α and ER-β) and oxytocin (OTR) receptors was performed on the oviduct and uterine tissue. The mRNA PR expression in the uterus during early stages of pregnancy and the luteal phase was higher than at other times. The mRNA ER-β expression in the oviduct during early pregnancy was less than in non-pregnant bitches. In the uterus, the mRNA ER-β expression was higher in the initial stages of pregnancy. The ER-α expression was higher in the oviduct and uterus in advanced stages of pregnancy. The mRNA OTR expression in the oviduct was lower than in the uterus in control group. The expression of this receptor in oviduct and the uterus was higher in the final stages of pregnancy, when compared with other phases. These data suggested that the serum progesterone concentrations probably exert a direct control on the PR and ER (α and β) expression and indirectly on OTR expression in the bitch oviduct and uterus.

  15. The influence of LiH on the rehydrogenation behavior of halide free rare earth (RE) borohydrides (RE = Pr, Er).

    Science.gov (United States)

    Heere, Michael; Payandeh GharibDoust, Seyed Hosein; Frommen, Christoph; Humphries, Terry D; Ley, Morten B; Sørby, Magnus H; Jensen, Torben R; Hauback, Bjørn C

    2016-09-21

    Rare earth (RE) metal borohydrides are receiving immense consideration as possible hydrogen storage materials and solid-state Li-ion conductors. In this study, halide free Er(BH4)3 and Pr(BH4)3 have been successfully synthesized for the first time by the combination of mechanochemical milling and/or wet chemistry. Rietveld refinement of Er(BH4)3 confirmed the formation of two different Er(BH4)3 polymorphs: α-Er(BH4)3 with space group Pa3[combining macron], a = 10.76796(5) Å, and β-Er(BH4)3 in Pm3[combining macron]m with a = 5.4664(1) Å. A variety of Pr(BH4)3 phases were found after extraction with diethyl ether: α-Pr(BH4)3 in Pa3[combining macron] with a = 11.2465(1) Å, β-Pr(BH4)3 in Pm3[combining macron]m with a = 5.716(2) Å and LiPr(BH4)3Cl in I4[combining macron]3m, a = 11.5468(3) Å. Almost phase pure α-Pr(BH4)3 in Pa3[combining macron] with a = 11.2473(2) Å was also synthesized. The thermal decomposition of Er(BH4)3 and Pr(BH4)3 proceeded without the formation of crystalline products. Rehydrogenation, as such, was not successful. However, addition of LiH promoted the rehydrogenation of RE hydride phases and LiBH4 from the decomposed RE(BH4)3 samples.

  16. Breast Cancer Survival Defined by the ER/PR/HER2 Subtypes and a Surrogate Classification according to Tumor Grade and Immunohistochemical Biomarkers

    Directory of Open Access Journals (Sweden)

    Carol A. Parise

    2014-01-01

    Full Text Available Introduction. ER, PR, and HER2 are routinely available in breast cancer specimens. The purpose of this study is to contrast breast cancer-specific survival for the eight ER/PR/HER2 subtypes with survival of an immunohistochemical surrogate for the molecular subtype based on the ER/PR/HER2 subtypes and tumor grade. Methods. We identified 123,780 cases of stages 1–3 primary female invasive breast cancer from California Cancer Registry. The surrogate classification was derived using ER/PR/HER2 and tumor grade. Kaplan-Meier survival analysis and Cox proportional hazards modeling were used to assess differences in survival and risk of mortality for the ER/PR/HER2 subtypes and surrogate classification within each stage. Results. The luminal B/HER2− surrogate classification had a higher risk of mortality than the luminal B/HER2+ for all stages of disease. There was no difference in risk of mortality between the ER+/PR+/HER2− and ER+/PR+/HER2+ in stage 3. With one exception in stage 3, the ER-negative subtypes all had an increased risk of mortality when compared with the ER-positive subtypes. Conclusions. Assessment of survival using ER/PR/HER2 illustrates the heterogeneity of HER2+ subtypes. The surrogate classification provides clear separation in survival and adjusted mortality but underestimates the wide variability within the subtypes that make up the classification.

  17. Enhanced 2.7 μm emission of Er/Pr-codoped water-free fluorotellurite glasses

    Energy Technology Data Exchange (ETDEWEB)

    Zhan, Huan [State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi’an 710119 (China); Key Laboratory for Physical Electronics and Devices of the Ministry of Education and Shaanxi Key Lab of Information Photonic Technique, School of Electronic and Information Engineering, Xi’an Jiaotong University, Xianning-xilu 28, Xi’an 710049 (China); Zhang, Aidong; He, Jianli; Zhou, Zhiguang [State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi’an 710119 (China); Li, Lu [State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi’an 710119 (China); Key Laboratory for Physical Electronics and Devices of the Ministry of Education and Shaanxi Key Lab of Information Photonic Technique, School of Electronic and Information Engineering, Xi’an Jiaotong University, Xianning-xilu 28, Xi’an 710049 (China); Shi, Tengfei; Xiao, Xusheng [State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi’an 710119 (China); Si, Jinhai, E-mail: jinhaisi@mail.xjtu.edu.cn [Key Laboratory for Physical Electronics and Devices of the Ministry of Education and Shaanxi Key Lab of Information Photonic Technique, School of Electronic and Information Engineering, Xi’an Jiaotong University, Xianning-xilu 28, Xi’an 710049 (China); and others

    2014-01-05

    Highlights: • Fluorotellurite glass is a new mid-IR fiber laser material. • Physical and chemical dehydration method removed OH group from bulk mid-IR glass. • Emission intensity at 2.71 μm was enhanced with the incorporation of Pr{sup 3+} ion. • The introduction of Pr{sup 3+} ion improved fluorescence lifetime from 1.07 to 1.55 ms. • Er/Pr-TZNF60 glass is a deal material to develop mid-IR fiber lasers at 2.7 μm. -- Abstract: Using physical and chemical dehydration technique and traditional melting and quenching method, we fabricated a group of Er/Pr-codoped water-free fluorotellurite glasses with composition of 60TeO{sub 2}–30ZnF{sub 2}–10NaF (TZNF60, mol%). The lifetime τ{sub f} of {sup 4}I{sub 11/2} → {sup 4}I{sub 13/2} transition, directly measured under the excitation by an optical parametric oscillator (OPO) laser system at 978 nm, in Er/Pr codoped fluorotellurite glasses is 1.37–1.55 ms, longer than that of Er-doped tellurite oxide (215 μs) and Er-doped fluorotellurite glasses (1.07 ms). The introduction of Pr{sup 3+} ions into Er-doped system increases the emission intensity at 2.71 μm (Er: {sup 4}I{sub 11/2} → {sup 4}I{sub 13/2}) and emission cross section as well. These advances partially arise from the absence of OH groups and low phonon energy with the addition of large amount of fluorides into oxide-based host glasses. With the high quantum efficiency and large figure of merit, Er/Pr-TZNF60 glass can be potentially a promising material for the development of mid-infrared fiber lasers at around 2.7 μm.

  18. Role of the PY Motif Containing Protein, WBP-2 in ER, PR Signaling and Breast Tumorigenesis

    Science.gov (United States)

    2007-03-01

    estradiol and expres- sion of endogenous estrogen-regulated gene, pS2 was measured by quantitative real time- polymerase chain reaction (RT-PCR). Upon...the ap- propriate specific antibodies. The precipitated genomic DNA associated with ER or WBP-2 was amplified by polymerase chain reaction (PCR) using...implicated in many diseases , including muscular dystrophy, Liddle’s syndrome, Alzheimer’s, Huntington disease and Cancers [16, 31, 35, 75]. Many

  19. Energy transfer based photoluminescence properties of co-doped (Er3+ + Pr3+): PEO + PVP blended polymer composites for photonic applications

    Science.gov (United States)

    Naveen Kumar, K.; Kang, Misook; Bhaskar Kumar, G.; Ratnakaram, Y. C.

    2016-04-01

    Er3+, Pr3+ singly doped and co-doped PEO + PVP polymer composites have been synthesized by conventional solution casting method. The structural analysis has been carried out for all these polymer composites from XRD analysis. Raman spectral studies confirm the ion-polymer interactions and polymer complex formation. Thermal properties of pure polymer film has also been clearly elucidated by TG/DTA profiles. Well defined optical absorption bands pertaining to Er3+ and Pr3+ are observed in the absorption spectral profile and these bands are assigned with corresponding electronic transitions. The polymer films containing singly doped Er3+ and Pr3+ ions have displayed green and red emissions at 510 nm (2H11/2 → 4I15/2) and 688 nm (3P0 → 3F3) respectively under UV excitation source. Comparing the emission spectra of singly Er3+ and co-doped Er3+ + Pr3+: PEO + PVP polymer films, a significant red emission pertaining to Pr3+ions is remarkably enhanced in co-doped polymer system. This could be ascribed to possible energy transfer from Er3+ to Pr3+ in co-doped polymer system. The energy transfer mechanism is clearly demonstrated using their emission performances, overlapped spectral profiles and also life time decay dynamics. Thus, it could be suggested that Er3+: PEO + PVP, Pr3+: PEO + PVP and (Er3+ + Pr3+): PEO + PVP blended polymer films are potential materials for several photonic applications.

  20. The structural and magnetic properties of Pr{sub 1−x}Er{sub x}Al{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Pathak, Arjun K., E-mail: pathak138@ameslab.gov [The Ames Laboratory, U.S. Department of Energy, Iowa State University, Ames, Iowa 50011-3020 (United States); Gschneidner, K. A.; Pecharsky, V. K. [The Ames Laboratory, U.S. Department of Energy, Iowa State University, Ames, Iowa 50011-3020 (United States); Department of Materials Science and Engineering, Iowa State University, Ames, Iowa 50011-2300 (United States)

    2015-05-07

    We report on the effect of Er addition to PrAl{sub 2} on the lattice parameters, magnetic behavior, heat capacity, and magnetocaloric effect by using x-ray diffraction, magnetization, and heat capacity measurements. Unlike Pr{sub 0.6}Er{sub 0.4}Al{sub 2}, other alloys we studied in the pseudobinary (Pr{sub 1−x}Er{sub x})Al{sub 2} system do not exhibit a sharp peak in heat capacity with the application of magnetic field. Both the cubic lattice parameter and the Curie temperature decrease with increasing Er concentration. The nuclear specific heat coefficient decreases from 660 mJ K mol{sup −1} for x = 0.05 to a nearly negligible value for x = 0.95. The magnetic entropy and adiabatic temperature change varies from 2 to 4 J mol{sup −1} K{sup −1} and 2.5 to 5 K at ΔH = 20 kOe for x = 0.05 to 0.95, respectively. These values of the magnetocaloric effect are comparable to those of the other rare-earth dialuminides systems.

  1. Evaluation of spectroscopic properties of Er3+/Yb3+/Pr3+: SrGdGa3O7 crystal for use in mid-infrared lasers

    Science.gov (United States)

    Xia, Houping; Feng, Jianghe; Wang, Yan; Li, Jianfu; Jia, Zhitai; Tu, Chaoyang

    2015-01-01

    Er3+/Yb3+/Pr3+: SrGdGa3O7 crystal was firstly grown by Czochralski method. Detailed spectroscopic analyses of Er3+/Yb3+/Pr3+: SrGdGa3O7 were carried out. Besides better absorption characteristic, the spectra of Er3+/Yb3+/Pr3+: SrGdGa3O7 show weaker up-conversion and near-infrared emissions as well as superior mid-infrared emission in comparison to Er3+: SrGdGa3O7 and Er3+/Yb3+: SrGdGa3O7 crystals. Furthermore, the self-termination effect for Er3+ 2.7 μm laser is suppressed successfully because the fluorescence lifetime of the 4I13/2 lower level of Er3+ decreases markedly while that of the upper 4I11/2 level changes slightly in Er3+/Yb3+/Pr3+: SrGdGa3O7 crystal. The sensitization effect of Yb3+ and deactivation effect of Pr3+ ions as well as the energy transfer mechanism in Er3+/Yb3+/Pr3+: SrGdGa3O7 crystal were also studied in this work. The introduction of Yb3+ and Pr3+ is favorable for achieving an enhanced 2.7 μm emission in Er3+/Yb3+/Pr3+: SrGdGa3O7 crystal which can act as a promising candidate for mid-infrared lasers. PMID:26369289

  2. Evaluation of spectroscopic properties of Er(3+)/Yb(3+)/Pr(3+): SrGdGa3O7 crystal for use in mid-infrared lasers.

    Science.gov (United States)

    Xia, Houping; Feng, Jianghe; Wang, Yan; Li, Jianfu; Jia, Zhitai; Tu, Chaoyang

    2015-09-15

    Er(3+)/Yb(3+)/Pr(3+): SrGdGa3O7 crystal was firstly grown by Czochralski method. Detailed spectroscopic analyses of Er(3+)/Yb(3+)/Pr(3+): SrGdGa3O7 were carried out. Besides better absorption characteristic, the spectra of Er(3+)/Yb(3+)/Pr(3+): SrGdGa3O7 show weaker up-conversion and near-infrared emissions as well as superior mid-infrared emission in comparison to Er(3+): SrGdGa3O7 and Er(3+)/Yb(3+): SrGdGa3O7 crystals. Furthermore, the self-termination effect for Er(3+) 2.7 μm laser is suppressed successfully because the fluorescence lifetime of the (4)I(13/2) lower level of Er(3+) decreases markedly while that of the upper (4)I(11/2) level changes slightly in Er(3+)/Yb(3+)/Pr(3+): SrGdGa3O7 crystal. The sensitization effect of Yb(3+) and deactivation effect of Pr(3+) ions as well as the energy transfer mechanism in Er(3+)/Yb(3+)/Pr(3+): SrGdGa3O7 crystal were also studied in this work. The introduction of Yb(3+) and Pr(3+) is favorable for achieving an enhanced 2.7 μm emission in Er(3+)/Yb(3+)/Pr(3+): SrGdGa3O7 crystal which can act as a promising candidate for mid-infrared lasers.

  3. Trends in use of contralateral prophylactic mastectomy by racial/ethnic group and ER/PR status among patients with breast cancer: A SEER population-based study.

    Science.gov (United States)

    Brown, Derek; Shao, Stephanie; Jatoi, Ismail; Shriver, Craig D; Zhu, Kangmin

    2016-06-01

    While differences in CPM use between White and Black patients are well known, it is not clear whether CPM use differs by estrogen/progesterone receptor (ER/PR) status of tumors and whether racial/ethnic differences in the use are affected by ER/PR status, which varies between racial groups. The purpose of this study was to investigate whether CPM usage differs by racial/ethnic group and ER/PR status among patients in the Surveillance, Epidemiology, and End Results (SEER) data. The study subjects were women with histologically confirmed unilateral breast cancer who underwent breast surgery between 1998 and 2011. Age-adjusted CPM use as a proportion of all surgically treated patients or all patients who had mastectomy was analyzed by racial/ethnic group, tumor behavior, and ER/PR status. Temporal trends in age-adjusted CPM use were presented by ER/PR status and racial/ethnic group. The analyses stratified by ER/PR status showed significant racial/ethnic differences in age-adjusted CPM use with non-Hispanic White and non-Hispanic Asian/Pacific Islander (API) patients having the most and least CPM use. Age-adjusted CPM use was significantly higher for ER+/PR+ tumors than ER-/PR- ones for each race/ethnicity group among patients with mastectomy. However, among patients with any breast surgeries, the only difference was a higher proportion of CPM use for ER-/PR- tumors (8.6%) than ER+/PR+ tumors (8.0%) in non-Hispanic Whites. CPM use has increased over time in all racial/ethnic groups despite ER/PR status. CPM usage was lower not only in non-Hispanic Blacks, but also in non-Hispanic API and Hispanic patients compared to non-Hispanic White patients. CPM usage tended to be higher for ER+/PR+ tumors, but the results varied when different denominators (all mastectomies vs. all breast surgeries) were used. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. Critical appraisal of cytological nuclear grading in carcinoma of the breast and its correlation with ER/PR expression

    Directory of Open Access Journals (Sweden)

    Bhargava Vidhi

    2008-01-01

    Full Text Available Background: Cytological nuclear grading is one of the several key prognostic factors that should be addressed in cytological analysis of breast carcinomas. Aims: To evaluate different cytological nuclear grading methods on fine needle aspirates of breast carcinomas and its correlation with histopathological nuclear grading as well as with the immunocytochemical expression of estrogen receptor (ER and progesterone receptor (PR. Materials and Methods: The smears from 30 cytologically proven cases of breast carcinoma were graded by - Nottingham′s modification of Scarff Bloom Richardson, Fisher′s modification of Black′s nuclear grading and Robinson′s cytological grading methods. 18 cases were available for correlation with histology grading. Results: Robbinson′s cytological grading system was found to have the best correlation with histopathology grades (P < 0.001 as well as ER (P = 0.003 and PR (P = 0.001 expression on smears. Conclusions: The Richardson′s cytology grading method is recommended for cytological nuclear grading along with ER / PR expression, without which the cytological diagnosis of breast carcinoma is incomplete.

  5. Computational Inferences of the Functions of Alternative/Noncanonical Splice Isoforms Specific to HER2+/ER-/PR- Breast Cancers, a Chromosome 17 C-HPP Study.

    Science.gov (United States)

    Menon, Rajasree; Panwar, Bharat; Eksi, Ridvan; Kleer, Celina; Guan, Yuanfang; Omenn, Gilbert S

    2015-09-04

    This study was conducted as a part of the Chromosome-Centric Human Proteome Project (C-HPP) of the Human Proteome Organization. The main objective is to identify and evaluate functionality of a set of specific noncanonical isoforms expressed in HER2-neu positive, estrogen receptor negative (ER-), and progesterone receptor negative (PR-) breast cancers (HER2+/ER-/PR- BC), an aggressive subtype of breast cancers that cause significant morbidity and mortality. We identified 11 alternative splice isoforms that were differentially expressed in HER2+/ER-/PR- BC compared to normal mammary, triple negative breast cancer and triple positive breast cancer tissues (HER2+/ER+/PR+). We used a stringent criterion that differentially expressed noncanonical isoforms (adjusted p value DMXL2 isoform 3, with a fold change of 27 compared to just two for the canonical protein. No previous reports link DMXL2 with any metabolic processes; the canonical protein is known to participate in signaling pathways. Our results clearly indicate distinct functions for the six overexpressed alternative splice isoforms, and these functions could be specific to HER2+/ER-/PR- tumor progression. Further detailed analysis is warranted as these proteins could be explored as potential biomarkers and therapeutic targets for HER2+/ER-/PR- BC patients.

  6. Study of the magnetocaloric properties of the antiferromagnetic compounds RGa2 (R = Ce, Pr, Nd, Dy, Ho and Er).

    Science.gov (United States)

    dos Reis, R D; da Silva, L M; dos Santos, A O; Medina, A M N; Cardoso, L P; Gandra, F G

    2010-12-08

    Magnetocaloric properties of antiferromagnetic RGa(2) (R = Ce, Pr, Nd, Dy, Ho and Er) compounds have been reported. These systems present an antiferromagnetic transition below 15 K and a field induced metamagnetic transition from the antiferromagnetic to ferromagnetic state. Our results show that the character of the magnetic field induced transition along the series affects the magnetocaloric properties. For the compounds with R = Ho, Dy and Er both negative and positive magnetocaloric effect (MCE) were observed above μ(0)ΔH = 2 T where the rate between negative and positive MCE contributions depends on how the magnetic transitions occur in these compounds. The evaluated values of maximum magnetocaloric properties of RGa(2) compounds are similar to other potential magnetic refrigerant materials reported in the literature.

  7. Integrative investigation on breast cancer in ER, PR and HER2-defined subgroups using mRNA and miRNA expression profiling

    Science.gov (United States)

    Dai, Xiaofeng; Chen, Ana; Bai, Zhonghu

    2014-10-01

    Exploring the molecular difference among breast cancer subtypes is of crucial importance in understanding its heterogeneity and seeking its effective clinical treatment. For this, several layers of information including immunohistochemical markers and a variety of high-throughput genomics approaches have been intensively used. Here we have explored the intrinsic differences among breast cancer subgroups defined by immunohistochemical expression (IHC) of hormone receptors ER and PR as well as human epidermal growth factor receptor 2 (HER2) using the mRNA and miRNA expression profiles of 115 tumors. A core basal group was further defined by epidermal growth factor receptor and cytokeratin 5/6 IHC expression and compared to triple negative group. A set of differentially expressed genes including 1015 mRNAs and 69 miRNAs was found to distinguish tumor subtypes whose generality was demonstrated using two independent data sets. The network was explored for each subtype and biomass synthesis signaling was found to play an important role in the core basal subgroup. This study contributes to elucidating the intrinsic relations among breast cancer subgroups defined by ER, PR and HER2 expression via integrating mRNA and miRNA expression. The results can avail functional studies of breast cancer with translational potential for clinical use.

  8. Imunoekspresi ER-α, PR, Wnt5a, dan HMGA2 pada Berbagai Gradasi Tumor Filodes Payudara

    Directory of Open Access Journals (Sweden)

    Fairuz Quzwain

    2016-09-01

    Full Text Available Abstrak Tumor filodes merupakan tumor fibroepitelial pada payudara yang secara mikroskopis ditandai dengan peningkatan selularitas sel stroma dan membentuk struktur seperti daun (leaf-like. Berbeda dengan tumor dari unsur epitel duktuli dan kelenjar payudara, penelitian peranan hormonal maupun faktor lain pada tumor filodes masih menunjukkan hasil yang inkonsisten sehingga menyebabkan patogenesis dan penatalaksanaan tumor ini dalam jalur hormonal masih kontroversi. Penelitian ini bertujuan menganalisis imunoekspresi faktor hormonal, yaitu estrogen receptor alpha (ER-α, progesteron receptor (PR, serta faktor nonhormonal HMGA2 dan wnt5a pada berbagai gradasi tumor filodes payudara. Dilakukan penilaian histologi dan imunoekspresi pada parafin blok jaringan tumor filodes payudara di Laboratorium Departemen Patologi Anatomi RSUP Dr. Hasan Sadikin Bandung periode tahun 2011 sampai 2014. Subjek penelitian dibagi menjadi 3 kelompok gradasi berdasarkan kriteria WHO tahun 2012, yaitu benign, borderline, dan malignant. Didapatkan 62 kasus tumor filodes yang sebagian besar menunjukkan distribusi imunoekspresi ER-α >50%, yaitu pada kategori benign sebanyak 35 dari 40 pasien. Terdapat korelasi signifikan histoskor ER-α, HMGA2, dan Wnt5a dengan gradasi histopatologis PT (p=0,002; p=0,001; p=0,040 dengan arah negatif untuk ER-α 2 (R=−0,423 serta positif untuk HMGA2 dan Wnt5a (R=0,439 dan R=0,243. Pada penelitian ini dapat disimpulkan semakin besar nilai histoskor ER-α maka semakin banyak diekpresikan pada gradasi benign dan semakin besar nilai histoskor HMGA2 serta Wnt5a semakin banyak ditemukan pada gradasi malignant.

  9. Structural and magnetic properties of two branches of the tripod-kagome-lattice family A2R3Sb3O14 (A = Mg, Zn; R = Pr, Nd, Gd, Tb, Dy, Ho, Er, Yb)

    Science.gov (United States)

    Dun, Z. L.; Trinh, J.; Lee, M.; Choi, E. S.; Li, K.; Hu, Y. F.; Wang, Y. X.; Blanc, N.; Ramirez, A. P.; Zhou, H. D.

    2017-03-01

    We present a systematic study of the structural and magnetic properties of two branches of the rare-earth tripod-kagome-lattice (TKL) family A2R3Sb3O14 (A = Mg, Zn; R = Pr, Nd, Gd, Tb, Dy, Ho, Er, Yb; here, we use abbreviation A-R, as in MgPr for Mg2Pr3Sb3O14 ), which complements our previously reported work on MgDy, MgGd, and MgEr [Z. L. Dun et al., Phys. Rev. Lett. 116, 157201 (2016), 10.1103/PhysRevLett.116.157201]. The present susceptibility (χdc, χac) and specific-heat measurements reveal various magnetic ground states, including the nonmagnetic singlet state for MgPr, ZnPr; long-range orderings (LROs) for MgGd, ZnGd, MgNd, ZnNd, and MgYb; a long-range magnetic charge ordered state for MgDy, ZnDy, and potentially for MgHo; possible spin-glass states for ZnEr, ZnHo; the absence of spin ordering down to 80 mK for MgEr, MgTb, ZnTb, and ZnYb compounds. The ground states observed here bear both similarities as well as striking differences from the states found in the parent pyrochlore systems. In particular, while the TKLs display a greater tendency towards LRO, the lack of LRO in MgHo, MgTb, and ZnTb can be viewed from the standpoint of a balance among spin-spin interactions, anisotropies, and non-Kramers nature of single-ion state. While substituting Zn for Mg changes the chemical pressure, and subtly modifies the interaction energies for compounds with larger R ions, this substitution introduces structural disorder and modifies the ground states for compounds with smaller R ions (Ho, Er, Yb).

  10. Effect of Monochromatic Light on Expression of Estrogen Receptor (ER) and Progesterone Receptor (PR) in Ovarian Follicles of Chicken.

    Science.gov (United States)

    Liu, Lingbin; Li, Diyan; Gilbert, Elizabeth R; Xiao, Qihai; Zhao, Xiaoling; Wang, Yan; Yin, Huadong; Zhu, Qing

    2015-01-01

    Artificial illumination is widely used in modern poultry houses and different wavelengths of light affect poultry production and behaviour. In this study, we measure mRNA and protein abundance of estrogen receptors (ERs) and progesterone receptors (PRs) in order to investigate the effect of monochromatic light on egg production traits and gonadal hormone function in chicken ovarian follicles. Five hundred and fifty-two 19-wk-old laying hens were exposed to three monochromatic lights: red (RL; 660 nm), green (GL; 560 nm), blue (BL; 480 nm) and control cool white (400-760 nm) light with an LED (light-emitting diode). There were 4 identical light-controlled rooms (n = 138) each containing 3 replicate pens (46 birds per pen). Water was supplied ad libitum and daily rations were determined according to the nutrient suggestions for poultry. Results showed that under BL conditions there was an increase in the total number of eggs at 300 days of age and egg-laying rate during the peak laying period. The BL and GL extended the duration of the peak laying period. Plasma melatonin was lowest in birds reared under BL. Plasma estradiol was elevated in the GL-exposed laying hens, and GL and BL increased progesterone at 28 wk of age. In the granulosa layers of the fifth largest preovulatory follicle (F5), the third largest preovulatory follicle (F3) and the largest preovulatory follicle (F1), ERα mRNA was increased by BL and GL. Treatment with BL increased ERβ mRNA in granulosa layers of F5, F3 and F1, while GL increased ERβ mRNA in F5 and F3. There was a corresponding increase in abundance of the proteins in the granulosa layers of F5, with an increase in PR-B, generated via an alternative splice site, relative to PR-A. Treatment with BL also increased expression of PR mRNA in all of the granulosa layers of follicles, while treatment with GL increased expression of PR mRNA in granulosa layers of SYF(small yellow follicle), F5 and F1. These results indicate that blue and green

  11. Effect of Monochromatic Light on Expression of Estrogen Receptor (ER and Progesterone Receptor (PR in Ovarian Follicles of Chicken.

    Directory of Open Access Journals (Sweden)

    Lingbin Liu

    Full Text Available Artificial illumination is widely used in modern poultry houses and different wavelengths of light affect poultry production and behaviour. In this study, we measure mRNA and protein abundance of estrogen receptors (ERs and progesterone receptors (PRs in order to investigate the effect of monochromatic light on egg production traits and gonadal hormone function in chicken ovarian follicles. Five hundred and fifty-two 19-wk-old laying hens were exposed to three monochromatic lights: red (RL; 660 nm, green (GL; 560 nm, blue (BL; 480 nm and control cool white (400-760 nm light with an LED (light-emitting diode. There were 4 identical light-controlled rooms (n = 138 each containing 3 replicate pens (46 birds per pen. Water was supplied ad libitum and daily rations were determined according to the nutrient suggestions for poultry. Results showed that under BL conditions there was an increase in the total number of eggs at 300 days of age and egg-laying rate during the peak laying period. The BL and GL extended the duration of the peak laying period. Plasma melatonin was lowest in birds reared under BL. Plasma estradiol was elevated in the GL-exposed laying hens, and GL and BL increased progesterone at 28 wk of age. In the granulosa layers of the fifth largest preovulatory follicle (F5, the third largest preovulatory follicle (F3 and the largest preovulatory follicle (F1, ERα mRNA was increased by BL and GL. Treatment with BL increased ERβ mRNA in granulosa layers of F5, F3 and F1, while GL increased ERβ mRNA in F5 and F3. There was a corresponding increase in abundance of the proteins in the granulosa layers of F5, with an increase in PR-B, generated via an alternative splice site, relative to PR-A. Treatment with BL also increased expression of PR mRNA in all of the granulosa layers of follicles, while treatment with GL increased expression of PR mRNA in granulosa layers of SYF(small yellow follicle, F5 and F1. These results indicate that blue

  12. Photoluminescence quenching by OH in Er- and Pr-doped glasses for 1.5 and 1.3 um optical amplifiers

    NARCIS (Netherlands)

    Faber, A.J.; Simons, D.R.; Yan, Y.; Waal, H. de

    1994-01-01

    In this paper we report on the effect of hydroxyl (OH) groups on the photoluminescence in the near IR (1.5 and 1.3 μm) in rare earth (Er, Pr)-doped glasses. The 1.5 μm emission of Er-doped phosphate glasses was studied, before and after a special heat treatment. The luminescent lifetime of the 1.5 μ

  13. Correlation of expression of ER,PR and c-erbB-2 with ultrasonographic features in invasive ductal cancer of breast

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Objective To analyze the relationship of the expression level of estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor-2(HER-2,c-erbB-2)of breast invasive ductal carcinoma(IDC)with ultrasonographic characteristics.Methods Totally 104 patients with IDCs confirmed pathologically were involved in this study.ER,PR and c-erbB-2 expression in the IDC specimens was determined by immunohistochemical staining technique.The correlation between the ultrasonographic features and the ...

  14. Synthesis, structure and properties of bimetallic sodium rare-earth (RE) borohydrides, NaRE(BH4)4, RE = Ce, Pr, Er or Gd.

    Science.gov (United States)

    Payandeh GharibDoust, SeyedHosein; Ravnsbæk, Dorthe B; Černý, Radovan; Jensen, Torben R

    2017-09-26

    Formation, stability and properties of new metal borohydrides within RE(BH4)3-NaBH4, RE = Ce, Pr, Er or Gd is investigated. Three new bimetallic sodium rare-earth borohydrides, NaCe(BH4)4, NaPr(BH4)4 and NaEr(BH4)4 are formed based on an addition reaction between NaBH4 and halide free rare-earth metal borohydrides RE(BH4)3, RE = Ce, Pr, Er. All the new compounds crystallize in the orthorhombic crystal system. NaCe(BH4)4 has unit cell parameters of a = 6.8028(5), b = 17.5181(13), c = 7.2841(5) Å and space group Pbcn. NaPr(BH4)4 is isostructural to NaCe(BH4)4 with unit cell parameters of a = 6.7617(2), b = 17.4678(7), c = 7.2522(3) Å. NaEr(BH4)4 crystallizes in space group Cmcm with unit cell parameters of a = 8.5379(2), b = 12.1570(4), c = 9.1652(3) Å. The structural relationships, also to the known RE(BH4)3, are discussed in detail and related to the stability and synthesis conditions. Heat treatment of NaBH4-Gd(BH4)3 mixture forms an unstable amorphous phase, which decomposes after one day at RT. NaCe(BH4)4 and NaPr(BH4)4 show reversible hydrogen storage capacity of 1.65 and 1.04 wt% in the fourth H2 release, whereas that of NaEr(BH4)4 continuously decreases. This is mainly assigned to formation of metal hydrides and possibly slower formation of sodium borohydride. The dehydrogenated state clearly contains rare-earth metal borides, which stabilize boron in the dehydrogenated state.

  15. Electronic and crystal structure, EPR and magnetic investigations of YF{sub 3}:1%RE (RE = Pr, Ho, Er and Tm) and LaF{sub 3}:1%Pr nanocrystals

    Energy Technology Data Exchange (ETDEWEB)

    Talik, E., E-mail: talik@us.edu.pl [Institute of Physics, University of Silesia, ul. Uniwersytecka 4, 40-007 Katowice (Poland); Zajdel, P.; Guzik, A.; Skrzypek, D. [Institute of Physics, University of Silesia, ul. Uniwersytecka 4, 40-007 Katowice (Poland); Lipińska, L.; Michalska, M. [Institute of Electronic Materials Technology, ul. Wólczyńska 133, 01-919 Warszawa (Poland)

    2014-12-15

    Highlights: • The thermal decomposition method was successfully applied for the first time in order to obtain the good quality nanocrystals of YF{sub 3}:1%RE. • For YF{sub 3}:1%Pr and LaF{sub 3}:1%Pr extra phase PrF{sub 3} was found. • The XPS energy gap is about 10 eV. • Surface contamination can be responsible for the deterioration of the optical properties of the composites. - Abstract: A new chemical synthesis route by a thermal decomposition of nitrates and acetates, preceded by solution displacement reaction, was successfully applied to obtain the YF{sub 3}:1%RE (RE = Pr, Ho, Er and Tm) and LaF{sub 3}:1%Pr nanocrystals. The samples were characterized by the following methods: X-ray diffraction, scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), magnetic susceptibility thermal dependence measurements and electron paramagnetic resonance (EPR). The obtained YF{sub 3}:1%RE (RE = Pr, Ho, Er and Tm) materials crystallized with orthorhombic symmetry, whilst LaF{sub 3}:1%Pr exhibits hexagonal structure. Chemical composition determined by EDX, XPS and magnetic measurements was close to nominal formula. SEM images show the nanometric size of the grains. Surface contamination can be suggested to be responsible for the deterioration of the optical properties of the composites.

  16. Spindeln i det sociala nätet : Hur svenska PR-byråer arbetar med utmaningar som medföljer strategin influencer marketing

    OpenAIRE

    Andersson, Sofie; Johansson, Anna

    2017-01-01

    Denna uppsats ämnar ge en ökad förståelse och förklara hur influencer marketing som marknadsföringsstrategi berör svenska PR-byråers arbete som marknadsförare. Författarna ämnar med hjälp av teorier som förklarar influencer marketings uppbyggnad, att kunna identifiera eventuella utmaningar för att öka förståelsen för hur PR-byråer bemöter strategin. Studien visar att PR-byrån hanterar utmaningar som berör 1) deras oförmåga att styra influencers, 2) konsekvenserna av konstant informationssprid...

  17. Association between acquired uniparental disomy and homozygous mutations and HER2/ER/PR status in breast cancer.

    Directory of Open Access Journals (Sweden)

    Musaffe Tuna

    Full Text Available BACKGROUND: Genetic alterations in cellular signaling networks are a hallmark of cancer, however, effective methods to discover them are lacking. A novel form of abnormality called acquired uniparental disomy (aUPD was recently found to pinpoint the region of mutated genes in various cancers, thereby identifying the region for next-generation sequencing. METHODS/PRINCIPAL FINDINGS: We retrieved large genomic data sets from the Gene Expression Omnibus database to perform genome-wide analysis of aUPD in breast tumor samples and cell lines using approaches that can reliably detect aUPD. aUPD was identified in 52.29% of the tumor samples. The most frequent aUPD regions were located at chromosomes 2q, 3p, 5q, 9p, 9q, 10q, 11q, 13q, 14q and 17q. We evaluated the data for any correlation between the most frequent aUPD regions and HER2/neu, ER, and PR status, and found a statistically significant correlation between the recurrent regions of aUPD and triple negative (TN breast cancers. aUPD at chromosome 17q (VEZF1, WNT3, 3p (SUMF1, GRM7, 9p (MTAP, NFIB and 11q (CASP1, CASP4, CASP5 are predictors for TN. The frequency of aUPD was found to be significantly higher in TN breast cancer cases compared to HER2/neu-positive and/or ER or PR-positive cases. Furthermore, using previously published mutation data, we found TP53 homozygously mutated in cell lines having aUPD in that locus. CONCLUSIONS/SIGNIFICANCE: We conclude that aUPD is a common and non-random molecular feature of breast cancer that is most prominent in triple negative cases. As aUPD regions are different among the main pathological subtypes, specific aUPD regions may aid the sub-classification of breast cancer. In addition, we provide statistical support using TP53 as an example that identifying aUPD regions can be an effective approach in finding aberrant genes. We thus conclude that a genome-wide scale analysis of aUPD regions for homozygous sequence alterations can provide valuable insights

  18. Hydrodynamic resistance parameters for ErPr rare-earth regenerator material under steady and periodic flow conditions

    Science.gov (United States)

    Pathak, M. G.; Helvensteijn, B. P.; Patel, V. C.; Ghiaasiaan, S. M.; Mulcahey, T. I.; Kashani, A.; Feller, J. R.

    2014-01-01

    The regenerator, typically a microporous structure that is subject to periodic flow of a cryogenic fluid, is a critical component of pulse tube or Stirling cryocoolers, which are widely used for high-demand aerospace and defense applications. In this investigation, experiments were conducted in which steady and oscillatory flows of helium were imposed on ErPr rare-Earth regenerator filler material and mass flow and pressure drop data were recorded under ambient temperature conditions. A computational fluid dynamics (CFD)-assisted method was applied for the analysis and interpretation of the experimental data. The permeability and inertial coefficients that lead to agreement between the experimental data and computational simulations were iteratively obtained. The Darcy permeability and Forchheimer inertial coefficients were obtained and were found to be functions of the system charge pressure, operating frequency, and compressor piston stroke within the studied range of interest. The results also exhibit that the periodic flow hydrodynamic resistance parameters are in general different than steady flow parameters.

  19. Role of PY Motif Containing Protein, WBP-2 in ER, PR Signaling and Breast Tumorigenesis

    Science.gov (United States)

    2009-09-01

    and expression of the endogenous estrogen-regulated gene, pS2 were measured by real time polymerase chain reaction (RT-PCR). The siWBP-2...amplified by polymerase chain reaction (PCR) using pri- mers specific for estrogen receptor binding site within the pS2 promoter. ChIP analyses demonstrated...WW-domains and PPXY motif have been implicated in many diseases , including muscular dystrophy, Liddle’s syndrome, Alzheimer’s, Huntington disease

  20. Effect of Chinese Herbs Bu-shen on PRLR, PR, ER mRNA of Decidue in Bromocriptine-induced Hypoprolactin Rat Abortion Model

    Institute of Scientific and Technical Information of China (English)

    Kun-ming LI; Sui-qi GUI; Li-hui JIANG; Li-min LU

    2003-01-01

    Objective To explore the effect of Chinese herbs on PRLR, PR, ER mRNA of decidue in Bromocriptine-induced hypoprolactin abortion rat model from gene transcription level, and observe the changes of blood PRL, P, E2.Methods RT-PCR method was taken to analyses the differences of PRLR, PR, ER mRNA in decidue between model group (A group) and model + herbs group (A + H group); RIA was taken to measure the serum levels of PRL, P, E2.Results PRLR, PR mRNA expression in decidue of Group A was significantly lower than the A+H group (P0.05); the abortion rate of Group A was 67%, Group A+H was 17%, the difference was significant; as for the PRL and P level of day 7~10, the A group was significantly lower than the A+H group (P<0.05).Conclusion Bromocriptine could induce abortion by declining the blood PRL, P level and downregulating PRLR, PR mRNA expression in decidue. Chinese herbs might maintain pregnancy by promoting PRL, P secretion and upregulating PRLR, PR mRNA expression in decidue.

  1. Unexpected magnetism, Griffiths phase, and exchange bias in the mixed lanthanide Pr0.6Er0.4Al2

    Energy Technology Data Exchange (ETDEWEB)

    Pathak, Arjun K. [Ames Laboratory; Paudyal, D. [Ames Laboratory; Jayasekara, W. T. [Ames Laboratory; Calder, S. [Oak Ridge National Laboratory; Kreyssig, A. [Ames Laboratory; Goldman, Alan I. [Ames Laboratory; Gschneidner, Karl A. [Ames Laboratory

    2014-06-01

    We report an unusual coexistence of ferromagnetism and ferrimagnetism, and metamagnetism in Pr0.6Er0.4Al2. In addition, this compound retains a clear Griffiths phase behavior even at 1 kOe magnetic field and shows a large exchange bias after field cooling from the paramagnetic state. The crystal-field excitations and opposite exchange interactions between nearest-neighbor and next-nearest-neighbor rare earth sites explain these behaviors.

  2. In vitro mechanism for down-regulation of ERalpha expression by epigallocatechin gallate in ER+/PR+ human breast cancer cells

    Science.gov (United States)

    De Amicis, Francesca; Russo, Alessandra; Avena, Paola; Santoro, Marta; Vivacqua, Adele; Bonofiglio, Daniela; Mauro, Loredana; Aquila, Saveria; Tramontano, Donatella; Fuqua, Suzanne AW; Andò, Sebastiano

    2015-01-01

    Scope Exposure of the breast to estrogens and other sex hormones is an important cancer risk factor and estrogen receptor down-regulators are attracting significant clinical interest. Epigallocatechin gallate (EGCG), a polyphenolic compound found in green tea, has gained considerable attention for its antitumor properties. Here we aimed to investigate the molecular mechanisms through which EGCG regulates ERα expression in ER+ PR+ breast cancer cells. Material and Methods Western blotting analysis, real time PCR and transient transfections of deletion fragments of the ERα gene promoter show that EGCG down-regulates ERα protein, mRNA and gene promoter activity with a concomitant reduction of ERα genomic and non genomic signal. These events occur through p38MAPK/CK2 activation, causing the release from Hsp90 of PR-B and its consequent nuclear translocation as evidenced by immunofluorescence studies. EMSA and ChIP assay reveal that, upon EGCG treatment, PR-B is recruited at the half PRE site on ERα promoter. This is concomitant with the formation of a corepressor complex containing NCoR and HDAC1 while RNA polymerase II is displaced. The events are crucially mediated by PR-B isoform, since they are abrogated with PR-B siRNA. Conclusions Our data provide evidence for a mechanism by which EGCG down-regulates ERα and explain the inhibitory action of EGCG on the proliferation of ER+ PR+ cancer cells tested. We suggest that the EGCG/PR-B signaling should be further exploited for clinical approach. PMID:23322423

  3. Enhanced 2.7 μm mid-infrared emissions of Er3+ via Pr3+ deactivation and Yb3+ sensitization in LiNbOsub>3sub> crystal.

    Science.gov (United States)

    Zhang, Peixiong; Chen, Zhenqiang; Hang, Yin; Li, Zhen; Yin, Hao; Zhu, Siqi; Fu, Shenhe; Li, Anming

    2016-10-31

    The use of Pr3+ codoping for enhancement of the transition of Er3+: 4Isub>11/2sub> → 4Isub>13/2sub> 2.7 μm emissions was investigated in the Er/Yb codoped LiNbOsub>3sub> crystal for the first time. It is found that the codoped of Pr3+ ion in Er3+, Yb3+ and Pr3+ triply doped LiNbOsub>3sub> crystal (Er/Yb/Pr: LN) greatly enhances Er3+: 2.7 μm emission under excitation of a common 970 nm laser diode, depopulates the lower laser level of Er3+:4Isub>13/2sub>, and has little influence on the higher laser level of Er3+:4Isub>11/2sub> at the same time for population inversion. The 2.7 μm emission characteristics and energy transfer were investigated in detail. The energy transition efficiency from lower laser level of Er3+:4Isub>13/2sub> to Pr3+:3Fsub>4sub> level is as high as 0.42, indicating that the Pr3+ ion is an effective deactivation ion for Er3+ ion in LiNbOsub>3sub> crystal. These results suggest that Er/Yb/Pr: LiNbOsub>3sub> crystal may become an attractive host for developing solid state lasers at around 2.7 μm under a conventional 970 nm LD pump.

  4. Spectroscopic properties of Pr3+ and Er3+ ions in lead-free borate glasses modified by BaF2

    Science.gov (United States)

    Pisarska, Joanna; Pisarski, Wojciech A.; Dorosz, Dominik; Dorosz, Jan

    2015-09-01

    Lead-free oxyfluoride borate glasses singly doped with Pr3+ and Er3+ were prepared and next investigated using absorption and luminescence spectroscopy. In the studied glass system, barium oxide was substituted by BaF2. Two luminescence bands of Pr3+ located at visible spectral region are observed, which correspond to 3P0-3H4 (blue) and 1D2-3H4 (reddish orange) transitions, respectively. The luminescence bands due to 1D2-3H4 transition of Pr3+ are shifted to shorter wavelengths, when BaO was substituted by BaF2. Near-infrared luminescence spectra of Er3+ ions in lead-free borate glasses modified by BaF2 correspond to 4I13/2-4I15/2 transition. Their spectral linewidths increase with increasing BaF2 concentration. The changes in measured lifetimes of rare earth ions are well correlated with the bonding parameters calculated from the optical absorption spectra.

  5. Synthesis, Characterization and Antibacterial Properties of Rare Earth (Ce3+, Pr3+, Nd3+, Sm3+, Er3+)Complexes with L-Aspartic Acid and o-Phenanthroline

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Five novel ternary complexes of rare earth ions with L-Aspartic acid (Asp) and o-phenanthroline (Phen) were synthesized in ethanol aqueous solution. Their compositions were characterized by elemental analysis, molar conductance, FT-IR, Raman, UV-VIS and TG-DTA. The compositions of the complexes were confirmed to be: RE(Asp)3PhenCl3·3H2O (RE: Ce3+, Pr3+, Nd3+, Sm3+, Er3+). The antibacterial activity test shows that all these complexes exhibit excellent antibacterial ability against Escherichia coli, Staphylococcus aureus and Candida albicans. The antimicrobial spectrum of the complexes are broad.

  6. New Materials Derived from Ybco: CrSr2RECu2O8 (RE = La, Pr, Nd, Eu, Gd, Tb, Dy, Y, Ho, Er, Lu).

    Science.gov (United States)

    Ruiz-Bustos, Rocío; Aguirre, Myriam H; Alario-Franco, Miguel A

    2005-05-02

    Eleven new oxides, derived from yttrium barium copper oxide by replacing the square-planar copper [Cu-O4] of the basal plane of the triple perovskite-based structure with octahedral Cr(IV), have been prepared at high pressure and temperature. Their crystal structures have been determined, and their complex microstructure has been established by means of high-resolution electron microscopy and electron diffraction. The materials have a general formula of CrSr2RECu2O8 (RE = La, Pr, Nd, Eu, Gd, Tb, Dy, Y, Ho, Er, and Lu); they are tetragonal, show the symmetry of space group P4/mmm, and do not appear to be superconducting.

  7. A five-gene model predicts clinical outcome in ER+/PR+, early-stage breast cancers treated with adjuvant tamoxifen.

    Science.gov (United States)

    Kerr, Daniel Alan; Wittliff, James L

    2011-10-01

    Primary breast carcinomas expressing both estrogen and progesterone receptors are most likely to respond to tamoxifen therapy, especially in patients with early-stage lesions. However, certain patients exhibit clinicopathologic features suggesting good prognosis relapse within 10 years, justifying a search for biomarkers identifying patients at risk for recurrence. Nine candidate genes associated with estrogen signaling were selected from microarray studies and combined with those for conventional biomarkers (ESR1, PGR, ERBB2). Expression of this 12-gene subset was analyzed by RT-qPCR in frozen tissue specimens from 60 early-stage, estrogen receptor (ER)+/progestin receptor (PR)+ breast cancers from patients treated with adjuvant tamoxifen. A multivariate model was created by Cox regression using a training data set and applied to an independent validation set. A five-gene model was developed from the training set (n = 36) that exhibited significant correlations with both relapse-free and overall survival. Applying this model to Kaplan-Meier regression, patients were separated into low-risk (100% relapse-free at 150 months) and high-risk (60% relapse-free at 150 months) groups (P = 0.03). When this model was applied to the validation set (n = 24), similar risk stratification was achieved for both relapse-free and overall survival (P = 0.01 and 0.04, respectively). We developed a five-gene model composed of PgR, BCL2, ERBB4 JM-a, RERG, and CD34 that identified early-stage, ER+/PR+ breast cancers in patients treated with tamoxifen that relapsed, although they exhibited clinicopathologic features suggesting good prognosis. Within this multivariate model, increased expression of PgR, ERBB4 JM-a, RERG, and CD34 was associated with increased survival, while increased expression of BCL2 was associated with decreased survival.

  8. Solubility of La, Pr, Eu, Er and Lu in a media of 1M ionic force of NaCl by 303 K; Solubilidad de La, Pr, Eu, Er y Lu en medio de fuerza ionica 1M de NaCl, a 303 K

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez G, J.J.; Solache R, M.J.; Jimenez R, M.; Rojas H, A. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    2002-07-01

    The solubility and the solubility product of La, Pr, Eu, Er and Lu in media of 1M ionic force of NaCl by 303 K was determined, by means of a radiochemical method and the pLn{sup -}pCH diagrams in free conditions of CO{sub 2} were constructed. Moreover, the non saturation and the saturated zones and with them the pCH precipitation bound were determined. Finally a comparison among the obtained data in this work and those reported in the literature in several media was realized. (Author)

  9. Effects of Er3+ and Pr3+ Substitution on Structural, Dielectric, Ferroelectric and Photoluminescence Properties of the BaTi0.9Zr0.1O3 Ceramic

    Science.gov (United States)

    Zouari, I.; Sassi, Z.; Seveyrat, L.; Perrin, V.; Zghal, S.; Abdelmoula, N.; Lebrun, L.; Khemakhem, H.

    2017-07-01

    BaTi0.9Zr0.1O3 (BZT), Ba1- x Ln2 x/3□ x/3Ti0.9Zr0.1O3 (with x = 0.5% mol and Ln = Er3+) (BZT-Er) and Ba1- x Ln2 x/3□ x/3Ti0.9Zr0.1O3 (with x = 0.5% mol and Ln = Pr3+) (BZT-Pr) were prepared via the conventional solid-state reaction method. X-ray diffraction showed that all these ceramics were in the single perovskite phase at room temperature (RT). The temperature dependence of dielectric behavior was investigated in the temperature range 25-225°C and exhibited a classical ferroelectric behavior. A slight decrease of the Curie temperature ( T C) with Pr3+ and Er3+ substitution was observed in addition to an increase in the maximum dielectric permittivity ( \\varepsilon_{r {max} }^' }} ) of about 40% for the BZT-Er. At RT, the ferroelectric and piezoelectric coefficients were decreased for BZT-Pr, but were maintained for BZT-Er with a piezoelectric coefficient ( d 33) of 185 pC/N, a planar electromechanical coupling factor of 30%, and a remanent polarization of 11.6 μC/cm2. The Raman bands as a function of temperature confirmed the paraelectric-ferroelectric phase transition of all those ceramics. The photoluminescence spectra showed that strong red (615 nm and 645 nm) and bright green (523 nm and 545 nm) emission bands were obtained, under excitation by laser at 488 nm at RT, for BZT-Pr and BZT-Er, respectively. These multifunctional materials showed a significant technological promise in coupling device applications.

  10. Completion Report for Well ER-12-4, Corrective Action Unit 99: Rainier Mesa - Shoshone Mountain (includes Errata Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Bechtel Nevada

    2006-05-01

    Well ER-12-4 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in May 2005, as part of a hydrogeologic investigation program for the Rainier Mesa-Shoshone Mountain Corrective Action Unit in the north-central portion of the Nevada Test Site. The well is located on Rainier/Aqueduct Mesa, northwest of Yucca Flat, within Area 12 of the Nevada Test Site. The well provided information regarding the radiological and physical environment near underground nuclear tests conducted in U12t Tunnel, information on the pre-Tertiary rocks in the area, and depth to the regional water table.

  11. Analysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2.

    Directory of Open Access Journals (Sweden)

    Veronika Mikitova

    Full Text Available BACKGROUND: Two phenylalanines (FF in an acidic tract (FFAT-motifs were originally described as having seven elements: an acidic flanking region followed by 6 residues (EFFDA-E. Such motifs are found in several lipid transfer protein (LTP families, and they interact with a protein on the cytosolic face of the ER called vesicle-associated membrane protein-associated protein (VAP. Mutation of which causes ER stress and motor neuron disease, making it important to determine which proteins bind VAP. Among other proteins that bind VAP, some contain FFAT-like motifs that are missing one or more of the seven elements. Defining how much variation is tolerated in FFAT-like motifs is a preliminary step prior to the identification of the full range of VAP interactors. RESULTS: We used a quantifiable in vivo system that measured ER targeting in a reporter yeast strain that over-expressed VAP to study the effect of substituting different elements of FFAT-like motifs in turn. By defining FFAT-like motifs more widely than before, we found them in novel proteins the functions of which had not previously been directly linked to the ER, including: two PKA anchoring proteins, AKAP220 and AKAP110; a family of plant LTPs; and the glycolipid LTP phosphatidylinositol-four-phosphate adaptor-protein-2 (FAPP-2. CONCLUSION: All of the seven essential elements of a FFAT motif tolerate variation, and weak targeting to the ER via VAP is still detected if two elements are substituted. In addition to the strong FFAT motifs already known, there are additional proteins with weaker FFAT-like motifs, which might be functionally important VAP interactors.

  12. Sintering effect on ageing behavior of rare earths (Pr6O11-Er2O3-Y2O3)-doped ZnO varistor ceramics

    Institute of Scientific and Technical Information of China (English)

    Choon-Woo Nahm

    2012-01-01

    The electrical properties and ageing behavior of the rare earths (Pr6O11-Er2O3-Y2O3)-doped ZnO varistor ceramics were systematically investigated at sintering temperature range of 1335-1350 ℃.With an increase in the sintering temperature,the sintered density increased from 5.41 to 5.64 g/cm3 and the average grain size increased from 5.8 to 7.9 μm.The varistor properties and ageing behavior were significantly affected by small sintering temperature range of 1335-1350 ℃.The breakdown field noticeably decreased from 5767 to 3628 V/cm with an increase in the sintering temperature.The varistor ceramics exhibited the highest nonlinear coefficient (43.2) at the sintering temperature of 1340 ℃.The varistor ceramics sintered at 1350 ℃ exhibited a surprisingly excellent stability by exhibiting 0.3% in the variation rate of the breakdown field and 0.3% in the variation rate of the nonlinear coefficient for ageing stress of 0.95 E1 mA/150 ℃/24 h.

  13. Solid state chemistry of rare earth oxides. Technical progress report, 1975--1976. [Pr/sub 7/O/sub 12/; Pr/sub 10/O/sub 18/; HfO/sub 2/. xEr/sub 2/O/sub 3/

    Energy Technology Data Exchange (ETDEWEB)

    Eyring, L.; Skarnulis, A.J.; Tuenge, R.T.; Von Dreele, R.B.

    1976-04-15

    It has been demonstrated that electron microscope images obtained at about 3A resolution for Pr/sub 7/O/sub 12/ are in agreement with calculated images based upon known structures. This establishes the efficacy of crystal structure image interpretation in structural terms, including the defect structure and mechanism of phase reactions, for these types of related phases whose structures are as yet beyond conventional means to determine. Further work on the epsilon (Pr/sub 10/O/sub 18/) phase is reported both utilizing electron optical methods and single crystal X-ray techniques. The ternary ceramic system HfO/sub 2/.xEr/sub 2/O/sub 3/ is being examined using electron optical techniques and ordering not hitherto reported is being observed. An interactive crystal structure image calculation system is being developed which will permit the immediate comparison of enhanced images synthesized from trial structures (including defects) and displayed in juxtaposition on a graphics unit. 22 fig. (auth)

  14. Fluxus-øer

    DEFF Research Database (Denmark)

    van der Meijden, Peter Alexander

    2008-01-01

    "Fluxus-øer" er en introduktion til Fluxus med udgangspunkt i den tyske galleri-ejer René Blocks samling, som udstillingen "Food for Thought" i Sukkerfabrikken i Stege (Møn) præsenterede et udvalg af. Artiklen beskriver Fluxus som et heterotopi som beskrevet af Michel Foucault i "Of Other Spaces"...

  15. Formation of La{sup 3+}, Pr{sup 3+}, Eu{sup 3+}, Er{sup 3+}, and Lu{sup 3+} complexes with chloride ions, in aqueous medium; Formacion de complejos de La{sup 3+}, Pr{sup 3+}, Eu{sup 3+}, Er{sup 3+} y Lu{sup 3+} con iones cloruro, en medio acuoso

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez R, E.; Jimenez R, M.; Solache R, M. [ININ, 52750 La Marquesa, Estado de Mexico (Mexico)

    2007-07-01

    The constants of stability of the complexes of La{sup 3+}, Pr{sup 3+}, Eu{sup 3+}, Er{sup 3+}, and Lu{sup 3+} with Cl{sup -} ions, its were determined, in the aqueous medium of HCI - HClO{sub 4} and by a solvent extraction method. The dinonyl naphtalene sulfonic acid in n-heptane was used as extractant. The lanthanides concentration, it was measured by a VIS spectrophotometry method and by another radiochemical. The ions specific interaction theory (SIT) it was used for the extrapolation to ionic force 0 M. The results indicate that the stability constants of the LnCI{sup 2+} species diminishes when increasing the ion force and the charge density. (Author)

  16. Near infrared and visible luminescence from xerogels covalently grafted with lanthanide [Sm(3+), Yb(3+), Nd(3+), Er(3+), Pr(3+), Ho(3+)] β-diketonate derivatives using visible light excitation.

    Science.gov (United States)

    Sun, Lining; Qiu, Yannan; Liu, Tao; Zhang, Jin Z; Dang, Song; Feng, Jing; Wang, Zhijuan; Zhang, Hongjie; Shi, Liyi

    2013-10-09

    A series of ternary lanthanide β-diketonate derivatives covalently bonded to xerogels (named as Ln-DP-xerogel, Ln = Sm, Yb, Nd, Er, Pr, Ho) by doubly functionalized alkoxysilane (dbm-Si) was synthesized in situ via a sol-gel process. The properties of these xerogel materials were investigated by Fourier-transform infrared (FT-IR) spectroscopy, field-emission scanning electron microscopy (FE-SEM), diffuse reflectance (DR) spectroscopy, thermogravimetric analyses, and fluorescence spectroscopy. The data and analyses suggest that the lanthanide derivatives have been covalently grafted to the corresponding xerogels successfully. Of importance here is that, after excitation with visible light (400-410 nm), the xerogels all show characteristic visible (Sm(3+)) as well as near-infrared (NIR; Sm(3+), Yb(3+), Nd(3+), Er(3+), Pr(3+), Ho(3+)) luminescence of the corresponding Ln(3+) ions, which is attributed to the energy transfer from the ligands to the Ln(3+) ions via an antenna effect. Exciting with visible light is advantageous over UV excitation. Furthermore, to the best of our knowledge, it is the first observation of NIR luminescence with visible light excitation from xerogels covalently bonded with the Sm(3+), Pr(3+), and Ho(3+) derivatives. Compared to lanthanide complexes (Ln = Er, Nd, Yb) functionalized periodic mesoporous organosilica (PMO) materials that exhibit similar optical properties reported in our previous work, the Ln-DP-xerogel (Ln = Sm, Yb, Nd, Er, Pr, Ho) in this case offer advantages in terms of ease of synthesis and handling and potentially low cost for emerging technological applications. Development of near-infrared luminescence of the lanthanide materials with visible light excitation is of strong interest to emerging applications such as chemosensors, laser systems, and optical amplifiers.

  17. Relationship Between Tumor Markers, ER/PR, HER2, Ki67 and CyclinA2 and Clinical Efficacy of Neoadjuvant Chemotherapy%乳腺癌新辅助化疗疗效及ER/PR,HER2,Ki67,CyclinA2的化疗预测作用

    Institute of Scientific and Technical Information of China (English)

    肖宇; 李惠平; 雷玉涛; 赵红梅; 修典荣; 王晶; 王墨培; 张淑兰; 张照辉

    2011-01-01

    Objective To explore the efficacy of neoadjuvant chemotherapy for breast cancer and predictive value of ER/PR, HER2,Ki67, and CyclinA2 in women with local advanced breast cancer (LABC).Methods From October 2004 to December 2009, 50 patients with stage Ⅰ - Ⅲ primary breast cancer received 2 - 6 cycles of neoadjuvant chemotherapy with anthracycline (EC/FEC) or taxanes-based (TP/TC or TE/PE/TEC) in our hospital.Forty-five of them were followed by definitive surgery and adjuvant chemotherapy.Estrogen receptor (ER)/progesterone receptor (PR) (50 cases), HER2 (48 cases), Ki67 (26 cases) and CyclinA2 (18 cases) were examined with immunohistochemistry before the neoadjuvant chemotherapy.Clinical responds, tumor lessen ratio, and toxicity of the treatment were estimated by ultrasonography and palpation afterwards.Results The medium maximum diameter of the tumors was 3.6 cm before neoadjuvant chemotherapy, and 2.2 cm after the treatment, no significant changes were observed (Z = - 5.723, P = 0.000).The clinical response rate was 76.0% (38/50) in the patients [6% (3/50) CR and 70% (35/50) PR], and SD was 22% (11/50) , PD 2.0% (1/50).In the 45 patients who underwent surgery, pCR was found in 3 cases (3/45, 6.7% ), and tpCR in 3 (3/45, 6.7% ).The 4-year disease-free survival (DFS) rate was 86.2% , and total survival rate was 93.1% [medium DFS 62.4 months, SE: 2.535, 95% CI ( 57.450 - 67.388 )].No significant difference was observed in tumor lessen ratio between pre-menopause and post-menopause patients (46.4% vs.40.6% , P = 0.536) , patients with positive and negative hormone receptors (43.0% vs.42.2% , P = 0.929), patients with positive and negative HER2 (41.3% vs.43.9% , P = 0.774), Ki67 (47.2% vs.43.1%, P=0.363), and CyclinA2 (34.3% vs.50.0%, P=0.375),or among those with high, moderate or low differentiation (44.1% , 42.9% , and 41.3%; P = 0.983 ) or different chemotherapy regimen ( TP/TC 52.7% , TE/PE/TEC 39.8% , and EC

  18. 子宫内膜增生组织中Cath-D、PCNA、ER和PR的表达%Expressions of Cath-D, PCNA, ER and PR in endometrial hyperplasia

    Institute of Scientific and Technical Information of China (English)

    吴忠新; 王冲; 谢慧君; 蔡德巍

    2012-01-01

    Objective To study the expressions of cathepsin D(Cath-D), proliferating cell nuclear antigen(PCNA), estrogen receptor(ER) and progesterone receptor(PR) in different types of endometrial hyperplasia Methods The positive expressions of Cath-D, PCNA, ER and PR in endometrial tissues were detected by immunohistochemical technique in 16 cases with atypical hyperplasia(AH) ,18 cases with complex hyperplasia (CH) ,26 cases with simple hyperplasia (SH), and 20 cases with normal endometrial proliferation(NC). Results The positive expression rates of ER of four groups were similar(PX). 05). The expression of PR in groups of AH and CH was lower than that in group C(PCH>AH. Conclusion Detecting the expressions of Cath-D, PCNA and PR in endometrial hyperplasia tissues is helpful in evaluating the prognosis and guiding treatment in the patients with endometrial hyperplasia.%目的 探讨组织蛋白酶D(Cath-D)、增殖细胞核抗原(PCNA)、雌激素受体(ER)和孕激素受体(PR)在不同类型子宫内膜增生组织中的表达.方法 60例子宫内膜增生患者分为不典型增生(16例,AH组)、复杂性增生(18例,CH组)和单纯性增生(26例,SH组);另选取20例正常的增殖期子宫内膜作为对照组.用免疫组化法检测增生子宫内膜组织Cath-D、PCNA、ER和PR的阳性表达率.结果 四组ER的阳性表达率相仿(P>0.05).AH组、CH组增生子宫内膜组织中的PR表达均明显低于对照组(P<0.05);AH组和CH组的Cath-D和PCNA的阳性表达率均明显高于对照组(P<0.01);SH组、CH组、AH组细胞核中Cath-D、PCNA的阳性表达率逐级递增,而PR的表达水平逐渐减弱.结论 检测子宫内膜增生组织中Cath-D、PCNA、PR的表达水平有助于评估子宫内膜增生的预后,指导临床治疗.

  19. PR[superscript 2]EPS: Preparation, Recruitment, Retention and Excellence in the Physical Sciences, Including Engineering. A Report on the 2004, 2005 and 2006 Science Summer Camps

    Science.gov (United States)

    Bachman, Nancy J.; Bischoff, Paul J.; Gallagher, Hugh; Labroo, Sunil; Schaumloffel, John C.

    2008-01-01

    Now in its fourth year, PR[superscript 2]EPS is a National Science Foundation funded initiative designed to recruit high school students to attend college majoring in the physical sciences, including engineering and secondary science education, and to help ensure their retention within the program until graduation. A central feature of the…

  20. Potential clinical relevance of uPA and PAI-1 levels in node-negative, postmenopausal breast cancer patients bearing histological grade II tumors with ER/PR expression, during an early follow-up.

    Science.gov (United States)

    Buta, Marko; Džodić, Radan; Đurišić, Igor; Marković, Ivan; Vujasinović, Tijana; Markićević, Milan; Nikolić-Vukosavljević, Dragica

    2015-09-01

    We evaluated urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) prognostic value in postmenopausal, node-negative breast cancer patients bearing tumors with estrogen receptor (ER)/progesterone receptor (PR) expression, treated with locoregional therapy alone, within an early follow-up. We focused our analysis on tumors of histological grade II in order to improve its prognostic value and, consequently, to improve a decision-making process. The cytosol extracts of 73 tumor samples were used for assessing several biomarkers. ER and PR levels were measured by classical biochemical method. Cathepsin D was assayed by a radiometric immunoassay while both uPA and PAI-1 level determinations were performed by enzyme-linked immunosorbent assays. HER-2 gene amplification was determined by chromogenic in situ hybridization (CISH) in primary tumor tissue. Patients bearing tumors smaller than or equal to 2 cm (pT1) or those with low PAI-1 levels (PAI-1 PAI-1 levels, respectively. Analyses of 4 phenotypes, defined by tumor size and PAI-1 status, revealed that patients bearing either pT1 tumors, irrespective of PAI-1 levels, or pT2,3 tumors with low PAI-1 levels, had similar disease-free interval probabilities and showed favorable outcome compared to those bearing pT2,3 tumors with high PAI-1 levels. Our findings suggest that tumor size and PAI-1, used in combination as phenotypes are not only prognostic but might also be predictive in node-negative, postmenopausal breast cancer patients bearing histological grade II tumors with ER/PR expression, during an early follow-up period.

  1. Expression of ER and PR in endometrial tumor%雌、孕激素受体在子宫内膜良恶性肿瘤组织中的表达及其意义

    Institute of Scientific and Technical Information of China (English)

    魏丽军; 丛娟; 李建民; 郭勇峰

    2008-01-01

    目的 检测分析雌激素受体(ER)、孕激素受体(PR)在子宫内膜良恶性肿瘤组织中的表达情况,探讨ER、PR与子宫内膜癌发生、发展的关系.方法 采用免疫组织化学SP法对58例子宫内膜癌、37例子宫内膜非典型增生,25例子宫内膜单纯性增生,25例正常子宫内膜标本进行ER和PR的检测.结果 ER、PR的阳性表达率在正常子宫内膜分别为24.0%、20.0%;单纯性增生52.0%、44.0%;非典型增生70.3%、64.9%;子宫内膜癌62.1%、56.8%.正常内膜到单纯型增生及非典型增生阳性表达率呈阶梯样上升,子宫内膜癌略低于非典型增生,两者均明显高于正常内膜(P<0.05).子宫内膜癌ER、PR强阳性表达率在不同组织分级中高分化Ⅰ级53.8%、53.8%;中分化Ⅱ级27.8%、22.2%,低分化Ⅲ级7.1%、0,低分化低表达.高分化高表达,Ⅰ级与Ⅲ级差异有统计学意义(P<0.05).ER、PR强阳性表达率在年龄≤50岁患者41.9%、38.7%,>50岁25.9%、22.2%,≤50岁组高于>50岁组,但差异无统计学意义.临床各分期之间差异无统计学意义(P>0.10).结论 正常子宫内膜到非典型增生、癌变过程中出现ER、PR异常高表达.ER、PR表达高低与癌组织分化程度密切相关,可能与子宫内膜癌的发生、预后有一定关系.%Objective To detect and analyze the expression of ER and PR in endometrial benign and malignant tumor,and to study its correlation of ER and PR with the establishment and development of endometrial carcinoma.Methods The expressions of ER and PR were examined by immunohistochemical method in 58 eases of endometrial carcinoma,37 cases of atypism endometrial hyperplasia,25 cases of simple endometrial carcinoma.and 25 eases of normal endometrium.Results The expressions of ER and PR were higher in normal endometrium,atypism endometrial hyperplasia and endometrial carcinoma.They were lower in endometrial carcinoma than in atypism endometrial hyperplasia,both were higher than that

  2. Magnetic hyperfine interactions on Cd sites of the rare-earth cadmium compounds R Cd (R =Ce , Pr, Nd, Sm, Gd, Tb, Dy, Ho, and Er)

    Science.gov (United States)

    Cavalcante, F. H. M.; Leite Neto, O. F. L. S.; Saitovitch, H.; Cavalcante, J. T. P. D.; Carbonari, A. W.; Saxena, R. N.; Bosch-Santos, B.; Pereira, L. F. D.; Mestnik-Filho, J.; Forker, M.

    2016-08-01

    This paper reports the investigation of the magnetic hyperfine field Bh f in a series of rare-earth (R ) cadmium intermetallic compounds R Cd and GdCd2 measured by perturbed angular correlation (PAC) spectroscopy using 111In/111Cd as probe nuclei at Cd sites as well as first-principles calculations of Bh f at Cd sites in the studied compounds. Vapor-solid state reaction of R metals with Cd vapor and the 111In radioisotope was found to be an appropriate route of doping rare-earth cadmium compounds with the PAC probe 111In/111Cd. The observation that the hyperfine parameters depend on details of the sample preparation provides information on the phase preference of diffusing 111In in the rare-earth cadmium phase system. The 111Cd hyperfine field has been determined in the compounds R Cd for the R constituents Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, and Er, in several cases as a function of temperature. For most R constituents, the temperature dependence Bh f(T ) of 111Cd:R Cd is consistent with ferromagnetic order of the compound. DyCd, however, presents a remarkable anomaly: a finite magnetic hyperfine field is observed only in the temperature interval 35 K ≤ T ≤ 80 K which indicates a transition from ferromagnetic order to a spin arrangement where all 4 f -induced contributions to the magnetic hyperfine field at the Cd site cancel. First-principles calculation results for DyCd show that the (π , π , 0) antiferromagnetic configuration is energetically more favorable than the ferromagnetic. The approach used in the calculations to simulate the R Cd system successfully reproduces the experimental values of Bh f at Cd sites and shows that the main contribution to Bh f comes from the valence electron polarization. The de Gennes plot of the hyperfine field Bh f of 111Cd:R Cd vs the 4 f -spin projection (g -1 )J reflects a decrease of the strength of indirect 4 f -4 f exchange across the R series. Possible mechanisms are discussed and the experimental results indicate that

  3. Metodología para evaluar el impacto de las erúbricas y las anotaciones de vídeo en las prácticas externas

    OpenAIRE

    Cebrián de la Serna, Manuel; Cebrian Robles, Daniel; Serrano Puerto, José

    2015-01-01

    Esta comunicación presenta el estudio del ePortafolios de evidencias multimedias para la evaluación formativa de los aprendizajes en las prácticas externas, analizando la naturaleza de las evidencias presentadas como las anotaciones producidas entre el tutor, los estudiantes de prácticas y estudiantes de las asignaturas teóricas en la universidad. Con esta metodología establecemos una relación poco habitual en el aprendizaje teórico-práctico, y la asignación de significados y análisis de esta...

  4. Relationship between sex hormone levels, ER, PR expression and breast fibroadenoma%性激素水平及ER、PR表达与乳腺纤维腺瘤的关系

    Institute of Scientific and Technical Information of China (English)

    马守霞; 张玉洲; 李彬

    2014-01-01

    Objective To study the changes of sex hormone level,estrogen receptor (ER) and progesterone receptor (PR) expression levels and their significance in fibroadenoma ofbreast.Methods The study objects were divided into fibroadenoma group and normal group.Chemiluminescence method was used to detect the luteal phase serum estrogen (E2),progesterone (P),prolactin (PRL) levels,and immunohistochemistry was used to detect ER,PR levels in fibroadenoma group.Results The level of E2 in fibroadenoma group was significantly higher than that in normal group,there was significant difference between the two groups (P < 0.05).There were no significant differences in P and PRL levels between the two groups (P > 0.05).The positive rate ER in fibroadenoma group was 94.7%,the positive rate of PR was 69.3%,and the differences were statistically significant for ER positive intensity between the two groups (P < 0.05).Conclusions The elevated levels of E2 and high expression levels of ER are the main reasons of breast fibroadenoma,which are similar to the causes of hyperplasia of mammry gland.So,active treatment should be given in clinics.%目的 研究性激素水平及雌激素受体(ER)、孕激素受体(PR)表达在乳腺纤维腺瘤中的变化及意义.方法 将研究对象分为纤维腺瘤组和正常组.采用化学发光法测定各组黄体期血清雌激素(E2)、孕酮(P)、泌乳素(PRL)水平,同时应用免疫组化法检测纤维腺瘤组中ER、PR的表达.结果 纤维腺瘤组E2水平明显高于正常组,差异有统计学意义(P<0.05),两组P、PRL水平比较差异无统计学意义(P>0.05).纤维腺瘤组中ER的阳性率为94.7%,PR的阳性率为69.3%,ER阳性强度差异有统计学意义(P<0.05).结论 E2升高及ER高表达是乳腺纤维腺瘤发生的主要原因,与乳腺增生病原因相似.据此,临床上可采取措施对其进行积极治疗.

  5. Upconversion Effects in Resonantly Pumped Er3+ and Pr3+ Doped Low Phonon-Energy Crystals for Eye-Safe Laser Applications

    Science.gov (United States)

    2015-07-14

    271-278 (2007). [15] Ferrier, A., Velazquez ,M., Doualan,J. L. and Moncorge, R., “Energy level and excited state absorption properties of Er3...Jian-hui, and Yang Gaobo, Optoelectronics Letters 8 (2012) 0273. [33] A. Ferrier, M. Velazquez , J. L. Doualan, and R. Moncorge, J. of AppL. Phys

  6. Expressions of ER, PR, and HOXA-11 in human endometrium during window period%种植窗口期人子宫内膜组织中 ER、PR及 HOXA-11的表达

    Institute of Scientific and Technical Information of China (English)

    刘子霞; 赵华; 王兴玲; 徐玲

    2014-01-01

    Aim:To investigate the expressions of ER , PR and HOXA-11 in human endometrium during window peri-od.Methods:Using immunohistochemical staining and RT-PCR the expressions of ER , PR and HOXA-11 in human endo-metrium during the window period were detected .According to pregnancy or not after IVF-ET, 78 cases of infertility pa-tients with tubal factors were divided into pregnant group ( n=86 ) and non-pregnant group ( n=67 ) .Results: The ex-pressions of PR and HOXA-11 in the glandular epithelium of the pregnant group were significantly lower than those of the non-pregnant group(P<0.001), while in the stromal cells were significantly higher than those of the non-pregnant group (P<0.001).The expressions of ER,PR and HOXA-11 mRNA of the pregnant group were higher than those of the non-pregnant group(P<0.05).There was correlation between level of P and PR,HOXA-11 in glandular epithelial(P<0.05). Conclusion:The down-regulated expressions of PR and HOXA-11 in glandular epithelial cells and the up-regulated expres-sions of PR and HOXA-11 in mesenchymal cells may be the reasons which lead to the decrease of endometrial receptivity .%目的:探讨雌孕激素受体(ER、PR)及同源框基因-11(HOXA-11)在人子宫内膜种植窗口期的表达。方法:采用免疫组化和RT-PCR方法检测ER、PR及HOXA-11在拟行IVF-ET患者排卵后子宫内膜种植窗口期的表达。按IVF-ET后是否妊娠将153例因输卵管因素不孕的患者分为未妊娠组(n=86)和妊娠组(n=67)。结果:免疫组化结果显示PR和HOXA-11在妊娠组腺上皮细胞中的表达均低于未妊娠组( P均<0.001),在间质细胞中的表达均高于未妊娠组(P均<0.001)。 RT-PCR 结果显示妊娠组子宫内膜 ER、PR 及 HOXA-11 mRNA 的相对表达量均高于未妊娠组(P均<0.05)。 P水平与腺上皮、间质PR及腺上皮HOXA-11蛋白表达有关(P均<0.05)。结论:种植窗口期内膜腺上皮PR、HOXA-11表

  7. Anàlisi de la dimensió de gènere en el marc del projecte INCLUD-ED per a desenvolupar pràctiques educatives inclusives Analysis of gender aspects in the framework of the INCLUD-ED project to develop inclusive educational practices Análisis de la dimensión de género en el marco del proyecto INCLUD-ED para desarrollar prácticas educativas inclusivas

    Directory of Open Access Journals (Sweden)

    Patricia Melgar

    2010-01-01

    ésultats académiquesVarious aspects, including gender, must be considered to boost the inclusivity of education. The risk of social exclusion may increase when gender is combined with other factors such as the cultural group, age or low socioeconomic level. Some studies have shown that there has been a significant improvement in girls’ academic results, which are better than those of boys in certain areas. However, the contribution of such studies is limited, as they describe the situation without examining its causes in-depth. This has led to new debates in the scientific community. The power relationships between the genders and the transmission traditional models of masculinity and femininity that can still be found in some school practices today have an impact on academic results.La promoción de la dimensión integradora de la educación debe contemplar las diferentes perspectivas, entre ellas la de género. El riesgo de exclusión social puede aumentar cuando la dimensión de género se combina con otras dimensiones como el grupo cultural, la edad o el bajo nivel socioeconómico. Algunos estudios indican que se ha producido una mejora significativa en los resultados académicos de las niñas, superando incluso los resultados de los niños en determinadas áreas. No obstante, las contribuciones aportadas son limitadas ya que describen la situación sin profundizar en las causas que llevan a esta situación. Ello ha reabierto recientemente nuevos debates en el marco de la comunidad científica. Las relaciones de poder entre género, así como la transmisión de modelos tradicionales de masculinidad y feminidad, que todavía se pueden observar hoy en día en algunas prácticas en las escuelas, tienen un impacto en los resultados académicos.

  8. Investigation of the R{sub 2}Se{sub 3}-Cu{sub 2}Se-In{sub 2}Se{sub 3} (R=La, Pr, Y and Er) systems at 870K and crystal structure of the R{sub 2}CuInSe{sub 5} (R=La, Ce and Pr) compounds

    Energy Technology Data Exchange (ETDEWEB)

    Huch, M.R. [Department of General and Inorganic Chemistry, Volyn State University, Voli Avenue 13, 43009 Lutsk (Ukraine); Gulay, L.D. [Department of General and Inorganic Chemistry, Volyn State University, Voli Avenue 13, 43009 Lutsk (Ukraine)]. E-mail: gulay@univer.lutsk.ua; Olekseyuk, I.D. [Department of General and Inorganic Chemistry, Volyn State University, Voli Avenue 13, 43009 Lutsk (Ukraine)

    2007-07-31

    Phase equilibria in R{sub 2}Se{sub 3}-Cu{sub 2}Se-In{sub 2}Se{sub 3} (R=La, Pr, Y and Er) systems at 870K were determined using X-ray powder diffraction. The existence of the RCuSe{sub 2} (LaCuS{sub 2} structure type, space group P2{sub 1}/c) and La{sub 5}Cu{sub 13}Se{sub 14} (unknown structure) compounds was confirmed in the R{sub 2}Se{sub 3}-Cu{sub 2}Se (R=La, Pr) sections. The formation of the solid solutions R{sub (2+x)/3}Cu{sub 2-x}Se{sub 2} (0bar xbar 1) (Er{sub 2/3}Cu{sub 2}S{sub 2} structure type, space group P3bar) and the ErCu{sub 5}Se{sub 4} compound with unknown structure was confirmed in the R{sub 2}Se{sub 3}-Cu{sub 2}Se (R=Y, Er) sections. The existence of the La{sub 3}In{sub 1.67}Se{sub 7} (Ce{sub 3}Al{sub 1.67}S{sub 7} structure type, space group P6{sub 3}) and La{sub 4}In{sub 4.67}Se{sub 13} (La{sub 4}In{sub 4.72}Se{sub 13} structure type, space group Pbam) compounds in the La{sub 2}Se{sub 3}-In{sub 2}Se{sub 3} system and the Pr{sub 3}InSe{sub 6} (Pr{sub 3}InSe{sub 6} structure type, space group Pnnm) compound in the Pr{sub 2}Se{sub 3}-In{sub 2}Se{sub 3} system was confirmed. No ternary compounds exist in the Er{sub 2}Se{sub 3}-In{sub 2}Se{sub 3} and Y{sub 2}Se{sub 3}-In{sub 2}Se{sub 3} sections. The formation of the CuInSe{sub 2}, CuIn{sub 3}Se{sub 5}, CuIn{sub 5}Se{sub 8}, CuIn{sub 7}Se{sub 11} and CuIn{sub 11}Se{sub 17} compounds in the Cu{sub 2}Se-In{sub 2}Se{sub 3} section was observed. The crystal structure of new quaternary R{sub 2}CuInSe{sub 5} (R=La, Ce and Pr) compounds (space group Pnma, a=1.20382(6)nm, b=0.41185(2)nm, c=1.7556(1)nm (for La{sub 2}CuInSe{sub 5}), a=1.19997(7)nm, b=0.40855(2)nm, c=1.7464(1)nm (for Ce{sub 2}CuInSe{sub 5}) and a=1.1973(3)nm, b=0.40649(9)nm, c=1.7408(4)nm (for Pr{sub 2}CuInSe{sub 5})) was determined.

  9. Bruken av nasjonale prøver

    DEFF Research Database (Denmark)

    Skov, Poul

    2010-01-01

    Artiklen beskriver resultater fra en omfattende evaluering af brugen af de nationale prøver i norsk grundskole. De nationale prøver er blevet modtaget positivt af mange kommuner og skoleledere og i mindre grad af lærerne. Resultaterne viser også, at prøverne er styrende for undervisningen, at bru...

  10. Bruken av nasjonale prøver

    DEFF Research Database (Denmark)

    Skov, Poul

    2010-01-01

    Artiklen beskriver resultater fra en omfattende evaluering af brugen af de nationale prøver i norsk grundskole. De nationale prøver er blevet modtaget positivt af mange kommuner og skoleledere og i mindre grad af lærerne. Resultaterne viser også, at prøverne er styrende for undervisningen, at bru...

  11. Hvorfor er sygeplejersker usynlige i offentlige medier?

    DEFF Research Database (Denmark)

    Joensen, Annemi Lund; Hall, Elisabeth

    2015-01-01

    Når der er sygeplejerelevante emner til debat i de offentlige medier på Færøerne, bærer debatten præg af sygeplejerskers manglende deltagelse. Sygeplejerskerne er usynlige. Et eksempel på dette er en debat om besparelser inden for ældreomsorgen. Til trods for at besparelsen fik omfattende konsekv...

  12. Structural Study of a Doubly Ordered Perovskite Family NaLnCoWO6 (Ln = Y, La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Yb): Hybrid Improper Ferroelectricity in Nine New Members.

    Science.gov (United States)

    Zuo, Peng; Colin, Claire V; Klein, Holger; Bordet, Pierre; Suard, Emmanuelle; Elkaim, Erik; Darie, Céline

    2017-07-17

    The compounds of the doubly ordered perovskite family NaLnCoWO6 (Ln = Y, La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, and Yb) were synthesized by solid-state reaction, nine of which (Ln = Y, Sm, Eu, Gd, Tb, Dy, Ho, Er, and Yb) are new phases prepared under high-temperature and high-pressure conditions. Their structural properties were investigated at room temperature by synchrotron X-ray powder diffraction and neutron powder diffraction. All of them crystallize in monoclinic structures, especially the nine new compounds have the polar space group P21 symmetry, as confirmed by second harmonic generation measurements. The P21 polar structures were decomposed and refined in terms of symmetry modes, demonstrating that the polar mode is induced by two nonpolar modes in a manner of Hybrid Improper Ferroelectricity. The amplitudes of these three major modes all increase with decreasing the Ln cation size. The spontaneous ferroelectric polarization is estimated from the neutron diffraction data of three samples (Ln = Y, Tb, and Ho) and can be as large as ∼20 μC/cm(2).

  13. Effects of post surface treatments including Er:YAG laser with different parameters on the pull-out bond strength of the fiber posts.

    Science.gov (United States)

    Arslan, Hakan; Kurklu, Duygu; Ayrancı, Leyla Benan; Barutcigil, Cagatay; Yılmaz, Cenk Burak; Karatas, Ertugrul; Topçuoğlu, Hüseyin Sinan

    2014-09-01

    This study aims to evaluate the effects of Er:YAG laser irradiation under different power settings on the pull-out bond strengths of fiber-reinforced composite posts. The crowns of single-rooted 60 teeth were removed by separation and the root canals were cleaned and shaped. Root canals were filled and post spaces were prepared. Sixty fiber posts were divided into five groups according to surface treatment methods as follows: an untreated control group, a sandblasting-coated group, and three groups undergoing surface preparation with Er:YAG laser under three different power settings (150, 300, and 450 mJ at 10 Hz for 60 s at 100-μs pulse duration). After root canal procedures, fiber posts were cemented to the root canal. After all of the specimens were set, pull-out tests were performed using a universal testing machine at a crosshead speed of 2 mm/min. The data were analyzed using one-way ANOVA and Tukey post-hoc test (p surface treatment. Surface treatment applied by 4.5-W Er:YAG laser increased the pull-out bond strength compared to the control group (p laser irradiation increased the pull-out bond strength of fiber posts to resin cement.

  14. Crystal growth, structure, and physical properties of Ln(Cu,Al)12 (Ln = Y, Ce, Pr, Sm, and Yb) and Ln(Cu, Ga)12 (Ln = Y, Gd-Er, and Yb).

    Science.gov (United States)

    Drake, Brenton L; Capan, C; Cho, Jung Young; Nambu, Y; Kuga, K; Xiong, Y M; Karki, A B; Nakatsuji, S; Adams, P W; Young, D P; Chan, Julia Y

    2010-02-17

    Single crystals of Ln(Cu,Al)12 and Ln(Cu,Ga)12 compounds (Ln = Y, Ce-Nd, Sm, Gd-Ho, and Yb for Al and Ln = Y, Gd-Er, Yb for Ga) have been grown by flux-growth methods and characterized by means of single-crystal x-ray diffraction, complemented with microprobe analysis, magnetic susceptibility, resistivity and heat capacity measurements. Ln(Cu,Ga)12 and Ln(Cu,Al)12 of the ThMn12 structure type crystallize in the tetragonal I4/mmm space group with lattice parameters a approximately 8.59 Å and c approximately 5.15 Å and a approximately 8.75 Å and c approximately 5.13 Å for Ga and Al containing compounds, respectively. For aluminium containing compounds, magnetic susceptibility data show Curie-Weiss paramagnetism in the Ce and Pr analogues down to 50 K with no magnetic ordering down to 3 K, whereas the Yb analogue shows a temperature-independent Pauli paramagnetism. Sm(Cu,Al)12 orders antiferromagnetically at T(N)approximately 5 K and interestingly exhibits Curie-Weiss behaviour down to 10 K with no Van Vleck contribution to the susceptibility. Specific heat data show that Ce(Cu,Al)12 is a heavy fermion antiferromagnet with T(N) approximately 2 K and with an electronic specific heat coefficient γ0 as large as 390 mJ K2 mol(-1). In addition, this is the first report of Pr(Cu,Al)12 and Sm(Cu,Al)12 showing an enhanced mass (approximately 80 and 120 mJ K(2) mol(-1)). For Ga containing analogues, magnetic susceptibility data also show the expected Curie-Weiss behaviour from Gd to Er, with the Yb analogue being once again a Pauli paramagnet. The antiferromagnetic transition temperatures range over 12.5, 13.5, 6.7, and 3.4 K for Gd, Tb, Dy, and Er. Metallic behaviour is observed down to 3 K for all Ga and Al analogues. A large positive magnetoresistance up to 150% at 9 T is also observed for Dy(Cu,Ga)12. The structure, magnetic, and transport properties of these compounds will be discussed.

  15. Metathesis synthesis, characterization, spectral and photoactivity studies of Ln2/3MoO4 (Ln=La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Er and Y)

    Institute of Scientific and Technical Information of China (English)

    Radha Velchuri; Suresh Palla; G. Ravi; Naveen Kumar Veldurthi; J.R. Reddy; M. Vithal

    2015-01-01

    Rare earth ortho-oxomolybdates of composition Ln2/3MoO4 (Ln=La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Er and Y) were prepared by metathesis reaction. All these materials were characterized by powder X-ray diffraction, Fourier transform-infrared spectroscopy (FT-IR) and UV-Vis diffuse reflectance spectra. The Rietveld analysis of all the samples was carried out to obtain the unit cell pa-rameters and reliability factors. All the materials were crystallized in tetragonal lattice withI41/a space group. The infrared spectra of all the samples were characterized by bands due to MoO42– units. The bandgap energies of all the samples were obtained from UV-Vis DRS spectra. The luminescence spectra of Ln2/3MoO4 (Ln=Pr, Eu and Dy) showed characteristic transitions of the rare earth ions. The visible light photocatalytic activity of all the samples was studied against degradation of methylene blue.

  16. Crystal structures of the R{sub 2}Pb{sub 3}Sn{sub 3}S{sub 12} (R = La, Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Er and Tm) compounds

    Energy Technology Data Exchange (ETDEWEB)

    Gulay, L.D. [Department of General and Inorganic Chemistry, Volyn State University, Voli Avenue 13, 43009 Lutsk (Ukraine)], E-mail: gulay@univer.lutsk.ua; Ruda, I.P. [Department of General and Inorganic Chemistry, Volyn State University, Voli Avenue 13, 43009 Lutsk (Ukraine); Marchuk, O.V. [Department of Physical and Colloidal Chemistry, Volyn State University, Voli Avenue 13, 43009 Lutsk (Ukraine); Olekseyuk, I.D. [Department of General and Inorganic Chemistry, Volyn State University, Voli Avenue 13, 43009 Lutsk (Ukraine)

    2008-06-12

    The crystal structures of the R{sub 2}Pb{sub 3}Sn{sub 3}S{sub 12} (R = La, Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Er and Tm) compounds (space group Pmc2{sub 1}, Pearson symbol oP40, a = 0.38992 (1) nm, b = 2.01175 (7) nm, c = 1.15140 (4) nm, R{sub I} 0.0785 for Ho{sub 2}Pb{sub 3}Sn{sub 3}S{sub 12}) were investigated using X-ray powder diffraction. The R{sub 1} atoms are surrounded by trigonal prisms with two additional atoms, the R{sub 2} atoms by distorted octahedra with one additional atom. The Pb{sub 1} and Pb{sub 3} atoms are surrounded by trigonal prisms with one additional atom, the Pb{sub 2} atoms by trigonal prisms with two additional atoms. Octahedral surrounding exists for Sn{sub 1} and Sn{sub 2}. The Sn{sub 3} atoms are located in trigonal bipyramids. Four or five neighbours surround the S atoms.

  17. Er danskerne racister

    DEFF Research Database (Denmark)

    Bech, Henning; Necef, Mehmet Ümit

    Igennem de seneste årtier er det blevet almindeligt at tale om, at der er en udbredt racisme i Danmark. Påstande om danskernes racisme, fremmedhad og diskrimination optræder dagligt i offentligheden og i medierne, og der henvises ofte til, hvad ’forskerne’ og de ’videnskabelige undersøgelser’ siger...... om emnet. Der kan da næppe heller være tvivl om, at der forekommer racistiske holdninger hos nogle danskere. Men er problemet så stort, som det gøres til i den offentlige debat? Bogen ønsker at afklare, hvorvidt der er videnskabelig dokumentation for påstandene om danskernes racisme. Den går i dybden...... med en række forskeres og eksperters udtalelser på området og præsenterer en grundig analyse af deres fremstilling af dansk racisme i forhold til emner som kultur, seksualitet, kriminalitet og arbejdsmarked....

  18. Normaludvikling er institutionsbestemt

    DEFF Research Database (Denmark)

    Gulløv, Eva

    2009-01-01

      Artiklen handler om de konsekvenser, den udbredte institutionalisering af småbørn har for opfattelser af børn, barndom og normaludvikling. Udgangspunktet er, at det at gå i daginstitution er så udbredt, at det betragtes som det normale. Ikke at gå i institution vækker bekymring, for dermed står...... forstås ved udvikling og sætte standarder for børn og normalitet. Artiklen skal vise, hvordan den institutionelle praksis med fastlagte rytmer, rutiner og aktiviteter præger opfattelser af, hvad børn skal kunne, og hvad der falder indenfor og udenfor den normale udvikling....

  19. Tunable Luminescence Contrast of Na0.5Bi4.5Ti4O15:Re (Re = Sm, Pr, Er) Photochromics by Controlling the Excitation Energy of Luminescent Centers.

    Science.gov (United States)

    Zhang, Qiwei; Zhang, Yao; Sun, Haiqin; Geng, Wei; Wang, Xusheng; Hao, Xihong; An, Shengli

    2016-12-21

    High luminescent switching contrast of photochromic materials is extremely important in improving the sensitivity and resolution of optical switches and high-density optical data storage devices. To date, conventional methods, such as tuning absorption and emission bands based on electron or resonance energy transfer mechanisms in well-known organic photochromic molecules or compounds, have routinely been adopted to tune luminescent switching behavior. However, these strategies and mechanisms are not effectively applied to luminescence switching in inorganic materials because their crystal structures differ strongly from those of organic materials. In this paper, we report a new method to significantly tune the luminescent switching contrast by modifying the excitation energy of luminescent centers in a newly synthesized photochromism material: Na0.5Bi4.5Ti4O15:Re (Re = Sm, Pr, Er). A significant enhancement of luminescence switching contrast was achieved when the luminescent centers were excited by low energy photons at a given irradiation wavelength, intensity, and time, compared with high excitation energy photons. The trend "the lower the excitation energy, the higher the luminescence switching contrast" is universal in different rare earth ion-doped Na0.5Bi4.5Ti4O15 ferroelectrics. The changes in the luminescent switching contrast based on excitation energy are ascribed to nonradiative energy transfer from the luminescent center to the color center by dipole-dipole interactions according to Dexter theory. This possible utilization of excitation energy at lower energy levels is usually less destructive to both information recording and the recording material itself during luminescent readout processes while achieving higher luminescence switching contrast.

  20. Solid-state synthesis and lanthanide photoluminescence of doped yttrium molybdo-antimonites, Y{sub 2−n}A{sub n}Mo{sub 4}Sb{sub 2}O{sub 18} (A=Pr, Sm, Eu, Tb, Dy, Ho, and Er; n=0.02–2) solid solutions

    Energy Technology Data Exchange (ETDEWEB)

    Mohitkar, Shrikant A.; Vidyasagar, K., E-mail: kvsagar@iitm.ac.in

    2015-05-15

    Abstract:: Y{sub 2−n}A{sub n}Mo{sub 4}Sb{sub 2}O{sub 18} (A=Pr, Sm, Eu, Tb, Dy, Ho, and Er; n=0.02–2) solid solutions were synthesized by a solid-state method and studied for their lanthanide photoluminescence. They show concentration dependent lanthanide photoluminescence and existence of concentration quenching phenomenon. The emission intensity and the fluorescence-lifetime are found to be highest for an optimum concentration of a given lanthanide ion in the solid solution series studied. The neat photoluminescence of A{sub 2}Mo{sub 4}Sb{sub 2}O{sub 18} (A=Pr, Sm, Eu, Tb, Dy, Ho, and Er) compounds involves partial concentration quenching. - Highlights: • Isostructural Y{sub 2−n}A{sub n}Mo{sub 4}Sb{sub 2}O{sub 18} (A=Pr, Sm, Eu, Tb, Dy, Ho, and Er; n=0.02–2) solid solutions have been synthesized. • Lanthanide photoluminescence of Y{sub 2−n}A{sub n}Mo{sub 4}Sb{sub 2}O{sub 18} (A=Pr, Sm, Eu, Tb, Dy, Ho, and Er; n=0.02–2) solid solutions has been studied. • Optimum concentration of each photoluminescent dopant for Y{sub 2−n}A{sub n}Mo{sub 4}Sb{sub 2}O{sub 18} (A=Pr, Sm, Eu, Tb, Dy, Ho, and Er; n=0.02 –2) solid solutions has been determined. • Red photoemission of Eu{sup 3+} in Y{sub 1.5}Eu{sub 0.5}Mo{sub 4}Sb{sub 2}O{sub 18} is visible to the naked eye. • Green photoemission of Tb{sup 3+} in Y{sub 1.7}Tb{sub 0.3}Mo{sub 4}Sb{sub 2}O{sub 18} is visible to the naked eye.

  1. Pige klik varsomt, thi scenen er skrå

    DEFF Research Database (Denmark)

    Sandvik, Kjetil

    2007-01-01

    At spille roller er en væsentlig del af mange computerspil. Nogle af disse roller er prædesignede af spildesignerne, andre er mere åbne og spilleren må derfor selv udfylde rollen. I såkaldte 'role-playing-games' (RPGs) har spilleren mulighed for at kreere sin egen rolle ved at anvende spillets...

  2. ER、PR、Her2/neu 在甲状腺乳头状癌中的表达及临床意义%Expression and clinical significance of ER,PR and Her2/neu in papillary thyroid carcinoma

    Institute of Scientific and Technical Information of China (English)

    董丽儒; 彭涛; 刘楠; 李双; 宋旭东

    2015-01-01

    目的:观察 ER、PR 和 Her2/neu 在甲状腺乳头状癌(papillary thyroid carcinoma,PTC)中的表达情况,并分析 ER、PR 和 Her2/neu 的表达与 PTC 的临床病理特征及其预后的关系。方法:采用免疫组化 SP 两步法检测108例 PTC、20例甲状腺滤泡性腺瘤及10例正常甲状腺组织标本中 ER、PR、Her2/neu 的表达,采用荧光原位杂交技术检测 Her2/neu 基因的表达。结果:ER、PR 在 PTC 组高表达,明显高于腺瘤组及正常组,应用免疫组化法和荧光原位杂交检测各组均未见 Her2/neu 表达;ER、PR、Her2/neu 的表达与患者年龄、性别、淋巴结是否转移及患者预后无显著相关性。结论:ER、PR 在 PTC 中表达敏感性较高,可以作为鉴别甲状腺良、恶性肿瘤的有效指标。Her2/neu 在 PTC 中无表达,其与 PTC 患者预后无关,与 Her2/neu 相关的靶向治疗药物不可应用于 PTC 的治疗。%Objective:To evaluate the expression of ER,PR and Her2 /neu,and to analyze the correlation between expression and clinical outcomes in papillary thyroid carcinoma.Methods:Immunohistochemistry was used to detect the expression of ER,PR and Her2 /neu,fluorescent in situ hybridization was used to detect the amplification state of Her2 /neu gene in 108 cases of papillary thyroid carcinoma,20 cases of thyroid adenoma and 10 cases of normal thy-roid tissue.Results:The expression of ER and PR were significally different between control group and PTC,the pro-tein expression and the gene amplification of Her2 /neu were not detected by immunohistochemical technique or fluo-rescent in situ hybridization in the histological samples of papillary thyroid carcinoma,whereas ER,PR and Her2 /neu had no correlation with the clinical features of papillary thyroid carcinoma.Conclusion:ER and PR are useful biomar-kers for the pathological diagnosis of PTC.Her2 /neu is nonspecific and has no contribution to the development of pa

  3. Absent progesterone receptor expression in the lymph node metastases of ER-positive, HER2-negative breast cancer is associated with relapse on tamoxifen.

    Science.gov (United States)

    Snell, Cameron E; Gough, Madeline; Middleton, Kathryn; Hsieh, Michael; Furnas, Lauren; Seidl, Brenton; Gibbons, Kristen; Pyke, Christopher; Shannon, Catherine; Woodward, Natasha; Armes, Jane E

    2017-04-17

    Progesterone receptor (PR) expression is prognostic in early stage breast cancer. There are several reports of discordant expression between primary tumour and axillary lymph node (ALN) metastasis expression of oestrogen receptor (ER) and PR. We sought to determine whether expression of these biomarkers in the synchronous ALN metastases of ER positive (+), HER2 negative (-) breast cancer could provide more accurate prognostic information. The retrospective cohort included 229 patients from a single institution with ER+, HER2- breast cancer who had synchronous ALN metastatic disease (2005-2014). PR expression was correlated with relapse-free survival, and subset analysis was performed for patients who received adjuvant tamoxifen or an aromatase inhibitor. One patient had an ER+ primary tumour, which was ER- in the ALN metastasis. 27 (11.3%) were PR- in the primary tumour and 56 (23.6%) in the ALN metastasis. The predominant change was from PR+ in the primary tumour to PR- in the lymph node. Absence of PR expression in the ALN was significantly associated with relapse; however, this was not the case in the primary tumour. In a subset analysis of patients taking adjuvant endocrine therapy, poorer prognosis was limited to those with PR- metastases on tamoxifen (HR=5.203, 95% CI 1.649 to 16.416, p=0.005). No significant prognostic effect of PR- metastases in patients taking aromatase inhibitors was seen (HR=1.519, 95% CI 0.675 to 3.418, p=0.312). Evaluation of PR expression in ALN metastasis may enable prediction of patients who are less likely to benefit from adjuvant tamoxifen. This study should be replicated in other cohorts. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  4. Hvilke Dødehavstekster er "sekteriske"?

    DEFF Research Database (Denmark)

    Holst, Søren

    2003-01-01

    Skønt Dødehavsrullerne antageligt tilhørte en gruppering, der boede i Qumran, tyder alt på, at mange af teksterne er forfattet andre steder. Artiklen undersøger den særlige sprogbrug, som antageligt er typisk for Qumran-samfundet, og som præger forbavsende få af tekserne. En meget stor del af tek...

  5. Oligo-nuclear silver thiocyanate complexes with monodentate tertiary phosphine ligands, including novel 'cubane' and 'step' tetramer forms of AgSCN : PR3 (1:1)4.

    Science.gov (United States)

    Bowmaker, Graham A; Di Nicola, Corrado; Effendy; Hanna, John V; Healy, Peter C; King, Scott P; Marchetti, Fabio; Pettinari, Claudio; Robinson, Ward T; Skelton, Brian W; Sobolev, Alexandre N; Tăbăcaru, Aurel; White, Allan H

    2013-01-07

    Adducts of a number of tertiary pnicogen ligands ER(3) (triphenyl-phosphine and -arsine (PPh(3),AsPh(3)), diphenyl,2-pyridylphosphine (PPh(2)py), tris(4-fluorophenyl)phosphine (P(C(6)H(4)-4F)(3)), tris(2-tolyl)phosphine (P(o-tol)(3)), tris(cyclohexyl)phosphine (PCy(3))), with silver(I) thiocyanate, AgSCN are structurally and spectroscopically characterized. The 1:3 AgSCN : ER(3) complexes structurally defined (for PPh(3),AsPh(3) (diversely solvated)) take the form [(R(3)E)(3)AgX], the thiocyanate X = NCS being N-bound, thus [(Ph(3)E)Ag(NCS)]. A 1:2 complex with PPh(2)py, takes the binuclear form [(pyPh(2)P)(2)Ag()Ag(PPh(2)py)(2)] with an eight-membered cyclic core. 1:1 complexes are defined with PPh(2)py, P(o-tol)(3) and PCy(3); binuclear forms [(R(3)P)Ag()Ag(PR(3))] are obtained with P(o-tol)(3) (two polymorphs), while novel isomeric tetranuclear forms, which may be envisaged as dimers of dimers, are obtained with PPh(2)py, and, as further polymorphs, with PCy(3); these latter may be considered as extensions of the 'cubane' and 'step' forms previously described for [(R(3)E)AgX](4) (X = halide) complexes. Solvent-assisted mechanochemical or solvent-assisted solid-state synthesis methods were employed in some cases, where complexes could not be obtained by conventional solution methods, or where such methods yielded a mixture of polymorphs unsuitable for solid-state spectroscopy. The wavenumbers of the ν(CN) bands in the IR spectra are in broad agreement with the empirical rule that distinguishes bridging from terminal bonding, but exceptions occur for compounds that have a double SCN bridged dimeric structure, and replacement of PPh(3) with PPh(2)py apparently causes a significant decrease in ν(CN) to well below the range expected for bridging SCN in these structures. (31)P CP MAS NMR spectra yield additional parameters that allow a correlation between the structures and spectra.

  6. Olie- og gast offshoreklyngen - inspirationskilde til kompetenceudvikling i SMV'er

    DEFF Research Database (Denmark)

    Søgaard, Villy

    2008-01-01

    Artiklen præsenterer off-shore klyngen og beskriver dens prækvalificeringspraksis samt betydningen heraf for opkvalificeringen af mindre metalvirksomheder i regionen. Virksomheden er forfattet sammen med Svend Ole Madsen...

  7. ER, PR and Her-2 expression status of breast cancer may affect the 18F-FDG uptake%乳腺癌ER、PR及Her-2的表达状态与18F-FDG摄取的研究进展

    Institute of Scientific and Technical Information of China (English)

    贾臻

    2011-01-01

    PET/CT has a wide application in the clinical management of breast cancer. Recent research has revealed that the expression status of ER, PR and Her-2 have an influence on 18F-FDG uptake. The measurement of "F-FDG standard uptake value may help confirm expression status of ER where a tumor with a higher uptake value usually indicates the tumor with no or less expression of ER. The change of018F-FDG uptake is predictive of responsiveness to tamoxifen therapy in patients with advanced ER(+) breast cancer. Although there are still some problems to be solved, we believe that with more research, "F-FDG PET/CT can be used to clarify tumor biological behavior, to identify therapeutic targets, to differentiate between different drug resistance mechanisms, to predict therapeutic effect and to help clinicians contribute to individualized therapy.%PET/CT在乳腺癌的临床应用中具有重要作用.研究发现,乳腺癌ER、PR及Her-2的表达是18F-FDG摄取的影响因素.18F-FDG标准摄取值的测定可有助于确认肿瘤的ER表达状态,摄取值高的肿瘤可能其ER状态为阴性.内分泌治疗前后18F-FDG标准摄取值的改变还可以预测他莫昔芬的疗效.虽然将其应用于临床中还存在一些需要解决的问题,但随着研究的深入,18F-FDG PET/CT在识别治疗靶点、鉴别耐药原因及预测疗效和个体化治疗等方面应用前景将更加广阔.

  8. Den gode præsentation

    DEFF Research Database (Denmark)

    Greve, Linda

    Den gode præsentation giver det teoretiske fundament og de praktiske værktøjer, der skal til for at skabe gode præsentationer, der virker efter hensigten. Læren er, at gode præsentationer kommer af grundig og metodisk velovervejet forberedelse – og af modet til at gå i relation med lytterne. Bogen...

  9. « Pour une éthique de la médiation culturelle ? », Raison présente, n° 177, 1er trimestre 2011

    OpenAIRE

    Girel, Sylvia

    2012-01-01

    Le dossier présenté par la revue Raison présente s’inscrit dans l’actualité des publications sur la question du rapport entre public(s) et art, sur la médiation culturelle, autant qu’il permet de montrer une pluralité des approches et conceptions de ce domaine d’intervention. Il fait écho, mais sous un angle d’approche différent, au numéro de la revue Lien social et politiques paru en 2008 sur le thème « Médiation culturelle : enjeux dispositifs et pratiques », et engage ainsi à prolonger et ...

  10. Ungdomslitteratur former(er) sig

    DEFF Research Database (Denmark)

    Henkel, Ayoe Qvist

    2016-01-01

    Igennem en 'mediesensitiv' analyse af romanen "Akavet" af Ronnie Andersen (2014) og perspektivering til andre aktuelle romaner for og med unge undersøger artiklen, hvordan ungdomslitteratur udvikler sig i dialog med digitale og mediebaserede impulser, og hvilke konsekvenser for udsigelserne om...... ungdomsliv og ungdomslitteraturens æstetik og mulige egenart, denne udvikling har. Artiklen baserer sig på en materialitetstilgang særligt inspireret af N. Katherine Hayles, som ikke tidligere har fået opmærksomhed i læsninger af ungdomslitteratur eller i diskussioner af ungdomslitteraturens mulige egenart......, at ungdomslitteratur drejer sig om unges udviklingsproces fra barndom og til voksenhed og dermed skildrer en overgang præget af linearitet, modning og vækst. Artiklen konkluderer, at der er ungdomslitteratur, der realiseres på andre præmisser, og Akavet kan ses som eksponent for en bevægelse fra ungdomslitteratur som...

  11. Hvem er vi? Hvem er de?

    DEFF Research Database (Denmark)

    Kryger, Niels

    2016-01-01

    Kommentaren tager afsæt i initiativer i de pædagogiske faglige foreninger i Europa EERA) og i Norden (NERA) og argumenterer for at det er forpligtelse for os som nordiske og europæiske pædagogiske forskere at gå op imod de stadigt mere ekskluderende vi-konstruktioner, som er blevet formuleret i f...

  12. Hvad er smag, og hvordan underviser man i og med smag? Udkast til en smagsdidaktik

    DEFF Research Database (Denmark)

    Qvortrup, Lars; Wistoft, Karen

    2016-01-01

    Hvad er smag, og hvordan underviser man i smag som undervisningens genstand eller med smag som et virkemiddel i undervisningen? Det er denne artikels to hovedspørgsmål. Formålet er at præsentere det, der kaldes en smagsdidaktisk refleksionsteori, dvs. en teori der reflekterer over, hvordan man un...

  13. Politik er ikke lykken

    DEFF Research Database (Denmark)

    Steenbuch, Johannes Aakjær

    2011-01-01

    Der er ikke længere nogen højere sandhed i livet end den, flertallet bestemmer sig for – og dermed ingen del af livet, der ikke er politisk. Højre- og venstrefløjen er i bund og grund enige - enige om, at det er politikernes opgave at forære os det gode liv. Dermed bliver demokratiet totalitært. ...

  14. Ideologi er noget bras

    DEFF Research Database (Denmark)

    Hansen, Brian Benjamin; Bjerre, Henrik Jøker

    medieområdet kan dette skifte betragtes som den endelige sejr for den post-ideologiske konsensus, der går ud fra, at der ikke mere er behov for politisk diskussion, og at vi aldrig mere skal indlade os på farlige politiske eksperimenter. Ideologi er noget bras, sagde jo allerede Poul Schlüter. Med inspiration......, ideologiske ramme for vore liv. Ideologi er noget bras, men bras er også ideologi....

  15. 乳腺X线致密度与激素受体和人表皮生长因子受体2的相关性探讨%Research between mammographic breast density and expression status of ER.PR and HER2 in breast cancer

    Institute of Scientific and Technical Information of China (English)

    崔春晓; 林青

    2012-01-01

    Objective To evaluate the relationship between mammographic density and estrogen receptor (ER). progesterone receptor (PR) and human epidermal growth factor 2 (HER2) status in breast cancer. Methods 615 cases of primary breast cancer confirmed by pathology were retrospectively collected. All the patients had undergone mammography. and the mammographic densities were classified into four types according the breast imaging report and data system (BI-RADS). ER. PR and HER2 status of breast cancer were measured by immunohistochemistry. Differences between mammographic density and ER. PR and HER2 were statistically analysed. Results Mammographic density turns from high density into low density gradually ( r =-0. 529. P 0. 05) or HER2 ( r =0.077. P =0.057>0. 05)in breast cancer. Conclusion Mammographic density was positive correlated with PR status in breast cancer, and was negative correlated with age.%目的 探讨乳腺X线致密度与乳腺癌中雌激素受体、孕激素受体及人表皮生长因子受体2之间是否具有相关性.方法 回顾性收集了615例经手术证实的原发性乳腺癌患者.就诊时均行乳腺X线摄影,并根据美国放射学会制定的乳腺影像报告及数据系统(BI-RADS)对乳腺X线致密度进行分型.所有病例术后或穿刺后标本均行免疫组织化学染色检测雌激素受体、孕激素受体及人表皮生长因子受体2表达水平,并分析乳腺X线致密度与激素受体、HER2表达及年龄因素之间的相关性.结果 乳腺X线致密度随年龄增长逐渐由高向低过渡(r =-0.629,P<0.001).乳腺X线致密度与孕激素受体表达呈正相关(r =0.099,P=0.014<0.05),与雌激素受体(r=0.016,P=0.699>0.05)及人表皮生长因子受体2表达(r =0.077,P=0.057>0.05)未见明显相关性.结论 乳腺X线致密度与乳腺癌孕激素受体表达呈正相关,与患者发病年龄呈负相关.

  16. Forbrugernes veje er mangfoldige

    DEFF Research Database (Denmark)

    Stacey, Julia; Nielsen, Niels Asger

    2005-01-01

    Fremtidens forbrugere vil have sunde fødevarer, der smager godt. Det lyder umiddelbart som et krav, der skulle være til at opfylde, men så enkelt er det nu ikke. De fødevarer, der smager godt, er ikke altid sunde, og en forbruger er ikke bare en forbruger. Nogle vil udfordres og overraskes. Andre...

  17. Fattigdom er blevet hverdag

    DEFF Research Database (Denmark)

    Andrade, Stefan Bastholm; Ditlevsen, Kia

    2014-01-01

    Det er sæson for julehjælp til fattige familier og donationer til hjemløse. Problemerne er ikke sæsonafhængige, men resten af året er indignationen sværere at spore. Fattigdom opfattes nemlig i stigende grad som et permanent individuelt vilkår og ikke som udtryk for samfundskrise...

  18. Hvad er talesprog?

    DEFF Research Database (Denmark)

    Steensig, Jakob

    2009-01-01

    Hvad er talesprog lingvistisk set? Hvad er kendetegnende for det i forhold til skriftsproget, og hvordan kan man arbejde med at udvikle en forståelse og værdsættelse af talesproget hos eleverne? Vores traditionelle sprogvidenskabelige beskrivelses¬apparat er udviklet til at beskrive skriftsproget...

  19. ER Stress and Lipid Metabolism in Adipocytes

    Directory of Open Access Journals (Sweden)

    Beth S. Zha

    2012-01-01

    Full Text Available The role of endoplasmic reticulum (ER stress is a rapidly emerging field of interest in the pathogenesis of metabolic diseases. Recent studies have shown that chronic activation of ER stress is closely linked to dysregulation of lipid metabolism in several metabolically important cells including hepatocytes, macrophages, β-cells, and adipocytes. Adipocytes are one of the major cell types involved in the pathogenesis of the metabolic syndrome. Recent advances in dissecting the cellular and molecular mechanisms involved in the regulation of adipogenesis and lipid metabolism indicate that activation of ER stress plays a central role in regulating adipocyte function. In this paper, we discuss the current understanding of the potential role of ER stress in lipid metabolism in adipocytes. In addition, we touch upon the interaction of ER stress and autophagy as well as inflammation. Inhibition of ER stress has the potential of decreasing the pathology in adipose tissue that is seen with energy overbalance.

  20. Hvordan kan jeg ane det jeg gør er rigtigt?

    DEFF Research Database (Denmark)

    Petersen, Anders

    2014-01-01

    Dømmekraft er i vælten. Men hvad er dømmekraft, og hvordan er det muligt at udvikle sin dømmekraft i en virkelighed, hvor målstyring fylder stadigt mere? Artiklen tager med dømmekraftbegrebet afsæt i den nye pædagoguddannelse. Bekendtgørelsen er præget af en opfordring til at have mere opmærksomh...

  1. Gevaarlijk spel: de verhouding tussen PR & voorlichting en journalistiek

    NARCIS (Netherlands)

    Prenger, M.; van der Valk, L.; van Vree, F.; van der Wal, L.

    2011-01-01

    Journalisten worden in hun werk in toenemende mate geconfronteerd met voorlichters, pr-medewerkers en spindoctors. Er is vrijwel geen overheidsdienst, onderneming, instelling en actiegroep die niet beschikt over een professioneel werkende communicatieafdeling. Dat levert veel spanningen op. Want ter

  2. Friluftsinstallationer i træer

    DEFF Research Database (Denmark)

    Skov, Simon; Thomsen, Iben Margrete

    2015-01-01

    Abebaner, treetop walking, high rope adventure, slackline, træhuse og parkour-baner er alle installationer, som bruger træerne som støtte, enten midlertidigt eller permanent. Den nye sport, turistattraktionen eller team building-redskabet sætter i alle tilfælde træerne på prøve. Der følger positiv...

  3. Præstationsledelse gentænkt

    DEFF Research Database (Denmark)

    Elmholdt, Claus Westergård; Sørensen, Niels Henrik

    2016-01-01

    smidige styrings- og vurderingssystemer, som er integreret i en dagligdags ledelsespraksis, der nedbryder KPI’er, opstiller meningsfulde mål og giver kontinuerlig, konkret og konstruktiv feedback. Vi diskuterer, med afsæt i tre caseeksempler, faldgruber i en klassisk tilgang til præstationsledelse og...

  4. Validation and use of a QuEChERS-based gas chromatographic-tandem mass spectrometric method for multiresidue pesticide analysis in blackcurrants including studies of matrix effects and estimation of measurement uncertainty.

    Science.gov (United States)

    Walorczyk, Stanisław

    2014-03-01

    A triple quadrupole GC-QqQ-MS/MS method was optimized for multiresidue analysis of over 180 pesticides in blackcurrants. The samples were prepared by using a modified quick, easy, cheap, effective, rugged and safe (QuEChERS) analytical protocol. To reduce matrix co-extractives in the final extract, the supernatant was cleaned up by dispersive-solid phase extraction (dispersive-SPE) with a mixture of sorbents: primary secondary amine (PSA), octadecyl (C18) and graphitized carbon black (GCB). The validation results demonstrated fitness for purpose of the streamlined method. The overall recoveries at the three spiking levels of 0.01, 0.05 and 0.2 mg kg(-1) spanned between 70% and 116% (102% on average) with relative standard deviation (RSD) values between 3% and 19% except for chlorothalonil (23%). Response linearity was studied in the range between 0.005 and 0.5 mg kg(-1). The matrix effect for each individual compound was evaluated through the study of ratios of the slopes obtained in solvent and blackcurrant matrix. The optimized method provided small matrix effect (30%, respectively. Following the application of "top-down" approach, the expanded measurement uncertainty was estimated as being 21% on average (coverage factor k=2, confidence level 95%). If compared with samples of other crops, the analyses of blackcurrants revealed a high percentage of exceedance of the legislative maximum residue levels (MRLs), as well as some instances of the detection of pesticides unapproved on this crop.

  5. Sulfate Exchange of the Nitrate-Type Layered Hydroxide Nanosheets of Ln2(OH)5NO3· nH2O for Better Dispersed and Multi-color Luminescent Ln2O3 Nanophosphors (Ln = Y0.98RE0.02, RE = Pr, Sm, Eu, Tb, Dy, Ho, Er, and Tm)

    Science.gov (United States)

    Wu, Xiaoli; Liu, Weigang; Li, Ji-Guang; Zhu, Qi; Li, Xiaodong; Sun, Xudong

    2016-07-01

    Through restricting thickness growth by performing coprecipitation at the freezing temperature of ~4 °C, solid-solution nanosheets (up to 5-nm thick) of the Ln2(OH)5NO3· nH2O layered hydroxide (Ln = Y0.98RE0.02; RE = Pr, Sm, Eu, Tb, Dy, Ho, Er, and Tm, respectively) were directly synthesized without performing conventional exfoliation. In situ exchange of the interlayer NO3 - with SO4 2- produced a sulfate derivative [Ln2(OH)5(SO4)0.5· nH2O] of the same layered structure and two-dimensional crystallite morphology but substantially contracted d 002 basal spacing (from ~0.886 to 0.841 nm). The sulfate derivative was systematically compared against its nitrate parent in terms of crystal structure and phase/morphology evolution upon heating. It is shown that the interlayer SO4 2-, owing to its bonding with the hydroxide main layer, significantly raises the decomposition temperature from ~600 to 1000 °C to yield remarkably better dispersed oxide nanopowders via a monoclinic Ln2O2SO4 intermediate. The resultant (Y0.98RE0.02)2O3 nanophosphors were studied for their photoluminescence to show that the emission color, depending on RE3+, spans a wide range in the Commission Internationale de l'Eclairage (CIE) chromaticity diagram, from blue to deep red via green, yellow, orange, and orange red.

  6. Vreden er over os

    DEFF Research Database (Denmark)

    Mehlsen, Camilla

    2006-01-01

    Urolige elever, cyklister - der giver fuck-finger, aggressive demonstranter. Samtiden er på vej ind i en æra domineret af vrede, siger rektor Lars-Henrik Schmidt, der er aktuel med bogen 'Om vreden'. Udgivelsesdato: Juni...

  7. Tale er guld

    DEFF Research Database (Denmark)

    Juel Henrichsen, Peter

    2014-01-01

    Mange danske kommuner er parate til at indfase automatisk talegenkendelse, men er samtidig nervøse efter en lang række dårlige businesscases i den nærmere fortid. Der klages over høje licenspriser og lavt serviceniveau, den typiske virkning af et de facto monopol på leverandørsiden. Denne artikel...

  8. MIT HJEM ER HVOR MIT HJERTE ER

    DEFF Research Database (Denmark)

    Høst, Jeppe Engset

    2014-01-01

    Ideen om at arbejde med det man kalder de stedbundne ressourcer på en ny måde, er relevant på Bornholm hvor events som blandt andet festivalen ’Wonderfestiwall’, strandfesten ’Vang Pier Beach Party’, karnevallet ’Svaneke Beach Party, kokkekonkurrencen ’Sol over Gudhjem’ og filmfestivalen ’Bornsho...

  9. Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets.

    Science.gov (United States)

    Ganley, Robert P; Iwagaki, Noboru; del Rio, Patricia; Baseer, Najma; Dickie, Allen C; Boyle, Kieran A; Polgár, Erika; Watanabe, Masahiko; Abraira, Victoria E; Zimmerman, Amanda; Riddell, John S; Todd, Andrew J

    2015-05-13

    The superficial dorsal horn of the spinal cord contains numerous inhibitory interneurons, which regulate the transmission of information perceived as touch, pain, or itch. Despite the importance of these cells, our understanding of their roles in the neuronal circuitry is limited by the difficulty in identifying functional populations. One group that has been identified and characterized consists of cells in the mouse that express green fluorescent protein (GFP) under control of the prion protein (PrP) promoter. Previous reports suggested that PrP-GFP cells belonged to a single morphological class (central cells), received inputs exclusively from unmyelinated primary afferents, and had axons that remained in lamina II. However, we recently reported that the PrP-GFP cells expressed neuronal nitric oxide synthase (nNOS) and/or galanin, and it has been shown that nNOS-expressing cells are more diverse in their morphology and synaptic connections. We therefore used a combined electrophysiological, pharmacological, and anatomical approach to reexamine the PrP-GFP cells. We provide evidence that they are morphologically diverse (corresponding to "unclassified" cells) and receive synaptic input from a variety of primary afferents, with convergence onto individual cells. We also show that their axons project into adjacent laminae and that they target putative projection neurons in lamina I. This indicates that the neuronal circuitry involving PrP-GFP cells is more complex than previously recognized, and suggests that they are likely to have several distinct roles in regulating the flow of somatosensory information through the dorsal horn.

  10. Nordslesvigeren er nr. 1

    DEFF Research Database (Denmark)

    Christensen, Steffen Lind

    2015-01-01

    Historien om de nordslesvigske krigsdeltagere under 1. Verdenskrig er traditionelt blevet behandlet i et nationalt perspektiv. Her benævnes soldaterne oftest som ’danske’. Denne artikel undersøger, hvordan nordslesvigske soldater på Østfronten selv udtrykte deres identitet i krigssituationen....... Udgangspunktet er krigsdeltagernes beskrivelser af og syn på dels de fællesskaber, de var en del af ved fronten, og dels de grupperinger, de anså for deres modsætninger. Hovedpointen er, at det mest italesatte tilhørsforhold blandt disse soldater var det regionale bånd til Nordslesvig....

  11. Skrot er godt

    DEFF Research Database (Denmark)

    Wenzel, Henrik

    2009-01-01

    Skrot er en god forretning for miljøet. Når vi genvinder metal - det vil sige indsamler, sorterer og smelter det om - udleder vi langt mindre CO2, end når vi bruger nye metaller udvundet fra undergrunden. Miljøgevinsten gælder alle metaller og høstes hver gang, vi genvinder dem. Det er et positiv...

  12. Metabolomics er fremtiden

    DEFF Research Database (Denmark)

    Pedersern, Birger

    2010-01-01

    Forskningen i fødevarer har fået et potent redskab i hånden. Metabolomics er vejen frem, mener professor Søren Balling Engelsen fra Københavns Universitet......Forskningen i fødevarer har fået et potent redskab i hånden. Metabolomics er vejen frem, mener professor Søren Balling Engelsen fra Københavns Universitet...

  13. er 1999

    DEFF Research Database (Denmark)

    Jensen, J. P.; Søndergaard, M.; Jeppesen, E.;

    små cladoceer og hjuldyr, og især er maksimumsforekom-sterne af calanoide vandlopper og de små og store cladoceer og daf-nier gået tilbage. Den gennemsnitlige biomasse af dafnier er derimod øget især p.g.a. stigning i de 25 % af søerne med størst forekomster. Dyreplanktons græsning Betragtet under et...

  14. ADHD er ikke hysteri

    DEFF Research Database (Denmark)

    Lange, Anne-Mette; Sørensen, Anders; Tranæs, Torben

    2014-01-01

    Livsværdi. Mennesker med ADHD bør kunne få et bedre liv, men man ved endnu ikke præcis hvordan.......Livsværdi. Mennesker med ADHD bør kunne få et bedre liv, men man ved endnu ikke præcis hvordan....

  15. Jeg Er blevet FRANKofil

    DEFF Research Database (Denmark)

    Andersson, Lasse

    2014-01-01

    afhængig af Frank Underwood fra serien House of Cards på den fremadstormende TV-streamingstjenesten Netflix. Jeg har opdaget et nyt internetbaseret datingforhold. Et surrealt, fedt miks af det kyniske og joviale personificeret i karakteren Frank Underwood, som er helt igennem ubehagelig, men fantastisk...... spillet af Kevin Spacey. Og tak til Spacey der for en tid har forladt teateret ’The Old Vic’ i London for at begejstre mig. Der er generelt to årsager til mine FRANKofile tilbøjeligheder. For det første er Netflix’s remake af den tyve år gamle BBC serie House of Cards efter min menig et stykke tv...... anden grund, til at jeg er blevet Frankofil, er, at jeg ikke skal sidde og vente på næste søndag efter søndag efter søndag for at få lov at se næste afsnit. Netflix lagde alle tretten timer af sæson 2 ud på nettet. Jeg afgør selv, hvornår jeg skal have mere Frank! Men på trods af mit narkomanlignende...

  16. ER Consolidated Quarterly Report October 2014

    Energy Technology Data Exchange (ETDEWEB)

    Cochran, John R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-10-01

    This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective actions and related Long- Term Stewardship (LTS) activities being implemented by Sandia National Laboratories, New Mexico (SNL/NM) ER for the April, May, and June 2014 quarterly reporting period. Section 2.0 provides the status of ER Operations activities including closure activities for the Mixed Waste Landfill (MWL), project management and site closure, and hydrogeologic characterizations. Section 3.0 provides the status of LTS activities that relate to the Chemical Waste Landfill (CWL) and the associated Corrective Action Management Unit (CAMU). Section 4.0 provides the references noted in Section I of this report.

  17. Genome-wide association studies identify four ER negative-specific breast cancer risk loci

    NARCIS (Netherlands)

    Garcia-Closas, Montserrat; Couch, Fergus J.; Lindstrom, Sara; Michailidouo, Kyriaki; Schmidt, Marjanka K.; Brook, Mark N.; Orr, Nick; Rhie, Suhn Kyong; Riboli, Elio; Feigelson, Heather S.; Le Marchand, Loic; Buring, Julie E.; Eccles, Diana; Miron, Penelope; Fasching, Peter A.; Brauch, Hiltrud; Chang-Claude, Jenny; Carpenter, Jane; Godwin, Andrew K.; Nevanlinna, Heli; Giles, Graham G.; Cox, Angela; Hopper, John L.; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Dicks, Ed; Howat, Will J.; Schoof, Nils; Bojesen, Stig E.; Lambrechts, Diether; Broeks, Annegien; Andrulis, Irene L.; Guenel, Pascal; Burwinkel, Barbara; Sawyer, Elinor J.; Hollestelle, Antoinette; Fletcher, Olivia; Winqvist, Robert; Brenner, Hermann; Mannermaa, Arto; Hamann, Ute; Meindl, Alfons; Lindblom, Annika; Zheng, Wei; Devillee, Peter; Goldberg, Mark S.; Lubinski, Jan; Kristensen, Vessela; Swerdlow, Anthony; Anton-Culver, Hoda; Doerk, Thilo; Muir, Kenneth; Matsuo, Keitaro; Wu, Anna H.; Radice, Paolo; Teo, Soo Hwang; Shu, Xiao-Ou; Blot, William; Kang, Daehee; Hartman, Mikael; Sangrajrang, Suleeporn; Shen, Chen-Yang; Southey, Melissa C.; Park, Daniel J.; Hammet, Fleur; Stone, Jennifer; Van't Veer, Laura J.; Rutgers, Emiel J.; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Peto, Julian; Schrauder, Michael G.; Ekici, Arif B.; Beckmann, Matthias W.; Silva, Isabel dos Santos; Johnson, Nichola; Warren, Helen; Tomlins, Ian; Kerin, Michael J.; Miller, Nicola; Marme, Federick; Schneeweiss, Andreas; Sohn, Christof; Truong, Therese; Laurent-Puig, Pierre; Kerbrat, Pierre; Nordestgaard, Borge G.; Nielsen, Sune F.; Flyger, Henrik; Milne, Roger L.; Arias Perez, Jose Ignacio; Menendez, Primitiva; Mueller, Heiko; Arndt, Volker; Stegmaier, Christa; Lichtner, Peter; Lochmann, Magdalena; Justenhoven, Christina; Ko, Yon-Dschun; Muranen, Taru A.; Aittomaki, Kristiina; Blomqvist, Carl; Greco, Dario; Heikkinen, Tuomas; Ito, Hidemi; Iwata, Hiroji; Yatabe, Yasushi; Antonenkova, Natalia N.; Margolin, Sara; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Balleine, Rosemary; Tseng, Chiu-Chen; Van den Berg, David; Stram, Daniel O.; Neven, Patrick; Dieudonne, Anne-Sophie; Leunen, Karin; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Peterlongo, Paolo; Peissel, Bernard; Bernard, Loris; Olson, Janet E.; Wang, Xianshu; Stevens, Kristen; Severi, Gianluca; Baglietto, Laura; McLean, Catriona; Coetzee, Gerhard A.; Feng, Ye; Henderson, Brian E.; Schumacher, Fredrick; Bogdanova, Natalia V.; Labreche, France; Dumont, Martine; Yip, Cheng Har; Taib, Nur Aishah Mohd; Cheng, Ching-Yu; Shrubsole, Martha; Long, Jirong; Pylkas, Katri; Jukkola-Vuorinen, Arja; Kauppila, Saila; Knight, Julia A.; Glendon, Gord; Mulligan, Anna Marie; Tollenaar, Robertus A. E. M.; Seynaeve, Caroline M.; Kriege, Mieke; Hooning, Maartje J.; van den Ouweland, Ans M. W.; van Deurzen, Carolien H. M.; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Balasubramanian, Sabapathy P.; Cross, Simon S.; Reed, Malcolm W. R.; Signorello, Lisa; Cai, Qiuyin; Shah, Mitul; Miao, Hui; Chan, Ching Wan; Chia, Kee Seng; Jakubowska, Anna; Jaworska, Katarzyna; Durda, Katarzyna; Hsiung, Chia-Ni; Wu, Peiei; Yu, Jyh-Cherng; Ashworth, Alan; Jones, Michael; Tessier, Daniel C.; Gonzalez-Neira, Anna; Pita, Guillermo; Alonso, M. Rosario; Vincent, Daniel; Bacot, Francois; Ambrosone, Christine B.; Bandera, Elisa V.; John, Esther M.; Chen, Gary K.; Hu, Jennifer J.; Rodriguez-Gil, Jorge L.; Bernstein, Leslie; Press, Michael F.; Ziegler, Regina G.; Millikan, Robert M.; Deming-Halverson, Sandra L.; Nyante, Sarah; Ingles, Sue A.; Waisfisz, Quinten; Tsimiklis, Helen; Makalic, Enes; Schmidt, Daniel; Bui, Minh; Gibson, Lorna; Mueller-Myhsok, Bertram; Schmutzler, Rita K.; Hein, Rebecca; Dahmen, Norbert; Beckmann, Lars; Aaltonen, Kirsimari; Czene, Kamila; Irwanto, Astrid; Liu, Jianjun; Turnbull, Clare; Rahman, Nazneen; Meijers-Heijboer, Hanne; Uitterlinden, Andre G.; Rivadeneira, Fernando; Olswold, Curtis; Slager, Susan; Pilarski, Robert; Ademuyiwa, Foluso; Konstantopoulou, Irene; Martin, Nicholas G.; Montgomery, Grant W.; Slamon, Dennis J.; Rauh, Claudia; Lux, Michael P.; Jud, Sebastian M.; Bruning, Thomas; Weaver, JoEllen; Harma, Priyanka; Pathak, Harsh; Tapper, Will; Gerty, Sue; Durcan, Lorraine; Trichopoulos, Dimitrios; Tumino, Rosario; Peeters, Petra H.; Kaaks, Rudolf; Campa, Daniele; Canzian, Federico; Weiderpass, Elisabete; Johansson, Mattias; Khaw, Kay-Tee; Travis, Ruth; Clavel-Chapelon, Francoise; Kolonel, Laurence N.; Chen, Constance; Beck, Andy; Hankinson, Susan E.; Berg, Christine D.; Hoover, Robert N.; Lissowska, Jolanta; Figueroa, Jonine D.; Chasman, Daniel I.; Gaudet, Mia M.; Diver, W. Ryan; Willett, Walter C.; Hunter, David J.; Simard, Jacques; Benitez, Javier; Dunning, Alison M.; Sherman, Mark E.; Chenevix-Trench, Georgia; Chanock, Stephen J.; Hall, Per; Pharoah, Paul D. P.; Vachon, Celine; Easton, Douglas F.; Haiman, Christopher A.; Kraft, Peter

    2013-01-01

    Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differe

  18. Genome-wide association studies identify four ER negative-specific breast cancer risk loci

    NARCIS (Netherlands)

    Garcia-Closas, Montserrat; Couch, Fergus J.; Lindstrom, Sara; Michailidouo, Kyriaki; Schmidt, Marjanka K.; Brook, Mark N.; Orr, Nick; Rhie, Suhn Kyong; Riboli, Elio; Feigelson, Heather S.; Le Marchand, Loic; Buring, Julie E.; Eccles, Diana; Miron, Penelope; Fasching, Peter A.; Brauch, Hiltrud; Chang-Claude, Jenny; Carpenter, Jane; Godwin, Andrew K.; Nevanlinna, Heli; Giles, Graham G.; Cox, Angela; Hopper, John L.; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Dicks, Ed; Howat, Will J.; Schoof, Nils; Bojesen, Stig E.; Lambrechts, Diether; Broeks, Annegien; Andrulis, Irene L.; Guenel, Pascal; Burwinkel, Barbara; Sawyer, Elinor J.; Hollestelle, Antoinette; Fletcher, Olivia; Winqvist, Robert; Brenner, Hermann; Mannermaa, Arto; Hamann, Ute; Meindl, Alfons; Lindblom, Annika; Zheng, Wei; Devillee, Peter; Goldberg, Mark S.; Lubinski, Jan; Kristensen, Vessela; Swerdlow, Anthony; Anton-Culver, Hoda; Doerk, Thilo; Muir, Kenneth; Matsuo, Keitaro; Wu, Anna H.; Radice, Paolo; Teo, Soo Hwang; Shu, Xiao-Ou; Blot, William; Kang, Daehee; Hartman, Mikael; Sangrajrang, Suleeporn; Shen, Chen-Yang; Southey, Melissa C.; Park, Daniel J.; Hammet, Fleur; Stone, Jennifer; Van't Veer, Laura J.; Rutgers, Emiel J.; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Peto, Julian; Schrauder, Michael G.; Ekici, Arif B.; Beckmann, Matthias W.; Silva, Isabel dos Santos; Johnson, Nichola; Warren, Helen; Tomlins, Ian; Kerin, Michael J.; Miller, Nicola; Marme, Federick; Schneeweiss, Andreas; Sohn, Christof; Truong, Therese; Laurent-Puig, Pierre; Kerbrat, Pierre; Nordestgaard, Borge G.; Nielsen, Sune F.; Flyger, Henrik; Milne, Roger L.; Arias Perez, Jose Ignacio; Menendez, Primitiva; Mueller, Heiko; Arndt, Volker; Stegmaier, Christa; Lichtner, Peter; Lochmann, Magdalena; Justenhoven, Christina; Ko, Yon-Dschun; Muranen, Taru A.; Aittomaki, Kristiina; Blomqvist, Carl; Greco, Dario; Heikkinen, Tuomas; Ito, Hidemi; Iwata, Hiroji; Yatabe, Yasushi; Antonenkova, Natalia N.; Margolin, Sara; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Balleine, Rosemary; Tseng, Chiu-Chen; Van den Berg, David; Stram, Daniel O.; Neven, Patrick; Dieudonne, Anne-Sophie; Leunen, Karin; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Peterlongo, Paolo; Peissel, Bernard; Bernard, Loris; Olson, Janet E.; Wang, Xianshu; Stevens, Kristen; Severi, Gianluca; Baglietto, Laura; McLean, Catriona; Coetzee, Gerhard A.; Feng, Ye; Henderson, Brian E.; Schumacher, Fredrick; Bogdanova, Natalia V.; Labreche, France; Dumont, Martine; Yip, Cheng Har; Taib, Nur Aishah Mohd; Cheng, Ching-Yu; Shrubsole, Martha; Long, Jirong; Pylkas, Katri; Jukkola-Vuorinen, Arja; Kauppila, Saila; Knight, Julia A.; Glendon, Gord; Mulligan, Anna Marie; Tollenaar, Robertus A. E. M.; Seynaeve, Caroline M.; Kriege, Mieke; Hooning, Maartje J.; van den Ouweland, Ans M. W.; van Deurzen, Carolien H. M.; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Balasubramanian, Sabapathy P.; Cross, Simon S.; Reed, Malcolm W. R.; Signorello, Lisa; Cai, Qiuyin; Shah, Mitul; Miao, Hui; Chan, Ching Wan; Chia, Kee Seng; Jakubowska, Anna; Jaworska, Katarzyna; Durda, Katarzyna; Hsiung, Chia-Ni; Wu, Peiei; Yu, Jyh-Cherng; Ashworth, Alan; Jones, Michael; Tessier, Daniel C.; Gonzalez-Neira, Anna; Pita, Guillermo; Alonso, M. Rosario; Vincent, Daniel; Bacot, Francois; Ambrosone, Christine B.; Bandera, Elisa V.; John, Esther M.; Chen, Gary K.; Hu, Jennifer J.; Rodriguez-Gil, Jorge L.; Bernstein, Leslie; Press, Michael F.; Ziegler, Regina G.; Millikan, Robert M.; Deming-Halverson, Sandra L.; Nyante, Sarah; Ingles, Sue A.; Waisfisz, Quinten; Tsimiklis, Helen; Makalic, Enes; Schmidt, Daniel; Bui, Minh; Gibson, Lorna; Mueller-Myhsok, Bertram; Schmutzler, Rita K.; Hein, Rebecca; Dahmen, Norbert; Beckmann, Lars; Aaltonen, Kirsimari; Czene, Kamila; Irwanto, Astrid; Liu, Jianjun; Turnbull, Clare; Rahman, Nazneen; Meijers-Heijboer, Hanne; Uitterlinden, Andre G.; Rivadeneira, Fernando; Olswold, Curtis; Slager, Susan; Pilarski, Robert; Ademuyiwa, Foluso; Konstantopoulou, Irene; Martin, Nicholas G.; Montgomery, Grant W.; Slamon, Dennis J.; Rauh, Claudia; Lux, Michael P.; Jud, Sebastian M.; Bruning, Thomas; Weaver, JoEllen; Harma, Priyanka; Pathak, Harsh; Tapper, Will; Gerty, Sue; Durcan, Lorraine; Trichopoulos, Dimitrios; Tumino, Rosario; Peeters, Petra H.; Kaaks, Rudolf; Campa, Daniele; Canzian, Federico; Weiderpass, Elisabete; Johansson, Mattias; Khaw, Kay-Tee; Travis, Ruth; Clavel-Chapelon, Francoise; Kolonel, Laurence N.; Chen, Constance; Beck, Andy; Hankinson, Susan E.; Berg, Christine D.; Hoover, Robert N.; Lissowska, Jolanta; Figueroa, Jonine D.; Chasman, Daniel I.; Gaudet, Mia M.; Diver, W. Ryan; Willett, Walter C.; Hunter, David J.; Simard, Jacques; Benitez, Javier; Dunning, Alison M.; Sherman, Mark E.; Chenevix-Trench, Georgia; Chanock, Stephen J.; Hall, Per; Pharoah, Paul D. P.; Vachon, Celine; Easton, Douglas F.; Haiman, Christopher A.; Kraft, Peter

    2013-01-01

    Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differe

  19. Genome-wide association studies identify four ER negative-specific breast cancer risk loci

    DEFF Research Database (Denmark)

    Garcia-Closas, Montserrat; Couch, Fergus J; Lindstrom, Sara

    2013-01-01

    Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including diff...

  20. Hvad er verdenskunst?

    DEFF Research Database (Denmark)

    Globaliseringen stiller kunsten over for hidtil usete udfordringer. Den verden kunstnerne udfolder sig i er på afgørende punkter forskellig fra den verden tidligere tiders kunst har placeret sig i: den er mindre, den forandrer sig hurtigere og den trænger sig mere på, end man kunne have tænkt sig...... indre og ydre komposition hos eksempelvis danske Odin Teatret, den guatemalanske forfatter Miguel Ángel Asturias, den britiske billedkunstner Chris Ofili, den tyske dramatiker Bertolt Brecht og den mexicanske filminstruktør Alejandro González Iñárritu....

  1. Ondskaben er fortryllende

    DEFF Research Database (Denmark)

    Schubart, Rikke

    2013-01-01

    Indlæg om tv-serien Once Upon a Time (2011-), der hører til genren fairytale fantasy, der blander eventyr og fantasy. Her bliver alle eventyr brugt i en fortælling om alle beboere i en lille by, der ikke ved, at de i virkeligheden er eventyr-karakterer.......Indlæg om tv-serien Once Upon a Time (2011-), der hører til genren fairytale fantasy, der blander eventyr og fantasy. Her bliver alle eventyr brugt i en fortælling om alle beboere i en lille by, der ikke ved, at de i virkeligheden er eventyr-karakterer....

  2. Ondskaben er fortryllende

    DEFF Research Database (Denmark)

    Schubart, Rikke

    2013-01-01

    Indlæg om tv-serien Once Upon a Time (2011-), der hører til genren fairytale fantasy, der blander eventyr og fantasy. Her bliver alle eventyr brugt i en fortælling om alle beboere i en lille by, der ikke ved, at de i virkeligheden er eventyr-karakterer.......Indlæg om tv-serien Once Upon a Time (2011-), der hører til genren fairytale fantasy, der blander eventyr og fantasy. Her bliver alle eventyr brugt i en fortælling om alle beboere i en lille by, der ikke ved, at de i virkeligheden er eventyr-karakterer....

  3. ER Stress and Angiogenesis.

    Science.gov (United States)

    Binet, François; Sapieha, Przemyslaw

    2015-10-01

    Proper tissue vascularization is vital for cellular function as it delivers oxygen, nutrients, hormones, and immune cells and helps to clear cellular debris and metabolic waste products. Tissue angiogenesis occurs to satisfy energy requirements and cellular sensors of metabolic imbalance coordinate vessel growth. In this regard, the classical pathways of the unfolded protein response activated under conditions of ER stress have recently been described to generate angiomodulatory or angiostatic signals. This review elaborates on the link between angiogenesis and ER stress and discusses the implications for diseases characterized by altered vascular homeostasis, such as cancer, retinopathies, and atherosclerosis.

  4. Trump har droppet fløjlshandskerne, nu da han er slået tilbage til start

    DEFF Research Database (Denmark)

    Hendricks, Vincent Fella

    2016-01-01

    Donald Trump vandt primærvalget ved hjælp af personangreb. I præsidentvalgkampens slutspurt har han nu taget den strategi op igen, selvom alle dømte den ude – og det er måske slet ikke så dumt, for det er det, Trump kan......Donald Trump vandt primærvalget ved hjælp af personangreb. I præsidentvalgkampens slutspurt har han nu taget den strategi op igen, selvom alle dømte den ude – og det er måske slet ikke så dumt, for det er det, Trump kan...

  5. Er talesprog en medieteknologi?

    DEFF Research Database (Denmark)

    Tække, Jesper

    2013-01-01

    motiver og viden, må give mening til hvad, der meddeles og selektere en forståelse (Luhmann 2000a). Formålet med og berettigelsen for medieteori er ud fra Marshall McLuhans (1967) devise, om at the medium is the message, at sammenligne, hvad det betyder for menneske og samfund, at der kommunikeres i ét...

  6. It er godt - basta!

    DEFF Research Database (Denmark)

    Bundsgaard, Jeppe

    2012-01-01

    Der er offentlig konsensus om at it i undervisningen fører til øget faglighed. Men it kan lige så godt resultere i ringere undervisning som i bedre - og ofte anvendes it helt traditionelt og fantasiløst....

  7. Er praksis prima?

    DEFF Research Database (Denmark)

    Holm, Claus

    2006-01-01

    Tiltroen til praktisk sans er i vækst, mens den teoretiske fornuft møder skepsis. Paradoksalt nok rammer den antiteoretiske bevægelse også universiteterne. To forskere advarer mod, at samfundet forlader sig på praksis....

  8. Patienten - hvor er patienten?

    DEFF Research Database (Denmark)

    Nielsen, Gitte; Dau, Susanne

    2011-01-01

    på, hvad der historisk og nutidigt karakteriserer teori og praksis, samt forholdet herimellem. I den empiriske del er der, med udgangspunkt i Gadamers hermeneutiske tilgang, foretaget tre kvalitative forkusgruppeinterview. Ét af sygeplejestuderende, ét af kliniske vejledere og ét af undervisere...

  9. Hvad er tidligt sprog

    DEFF Research Database (Denmark)

    Skriver Jensen, Anders

    2009-01-01

    Forfatteren argumenterer for at "early literacy" kan oversættes til "tidligt sprog"; særligt når der er tale om en helhedsorienteret tilgang med vægt på sprog som et alsidigt medie for kommunikation- og betydningsskabelse. Med inspiration fra Jerome Bruners kulturpsykologi diskuteres mulige...

  10. Iran : Præstestyret - under udvikling eller afvikling

    DEFF Research Database (Denmark)

    Rahigh-Aghsan, Ali

    2010-01-01

    Man hører ikke længere om gadeprotester i Teheran. Efter de voldsomme kampe i Teheran først på året, er det tilsyneladende lykkedes den Islamiske Republik at tvinge oppositionen til tavshed. Ifølge lederen af 'den grønne bevægelse' og tidligere præsidentkandidat, Mousavi, er det islamiske regimes...

  11. Al verden er en scene

    DEFF Research Database (Denmark)

    Sandvik, Kjetil; Waade, Anne Marit

    2006-01-01

    Rollespil er blevet hot, og opmærksomheden omkring rollespil er eksploderet de seneste år: Virksomheder, politikere, medier og forskere har fået øjnene op for de kulturelle og økonomiske muligheder...

  12. Vi lider af prætraumatisk stress

    DEFF Research Database (Denmark)

    Hansen, Brian Benjamin

    2009-01-01

    Vi lider af prætraumatisk stress. Vi vil nemlig nå det hele og presser konstant nye aftaler ind i vores kalender. Det eneste, der hjælper, er at ’gøre intet’ – men kan man overhovedet det? Udgivelsesdato: 30.09.09......Vi lider af prætraumatisk stress. Vi vil nemlig nå det hele og presser konstant nye aftaler ind i vores kalender. Det eneste, der hjælper, er at ’gøre intet’ – men kan man overhovedet det? Udgivelsesdato: 30.09.09...

  13. Hvid er et usynligt ideal

    DEFF Research Database (Denmark)

    Mehlsen, Camilla

    2010-01-01

    Salget af hudblegecremer er eksploderet. Hvorfor drømmer så mange om at få lys hud? Hvorfor vil børn hellere lege med hvide dukker end brune? Svaret er, at hvid er et globalt ideal. Interview med Dorthe Staunæs og Les Back....

  14. Er HR ude i tovene?

    DEFF Research Database (Denmark)

    Poulfelt, Flemming

    2015-01-01

    HR: Er der behov for nytænkning i HR-land? Artikler i Harvard Business Review - bakket op af en dansk undersøgelse - konkluderer, at HR stadig mangler gennemslagskraft i virksomhederne. Er HR ude i tovene? ... For i undersøgelsen "Ny Dansk Ledelse" (maj 2015), som er baseret på danske lederes...

  15. ESO PR Highlights in 2006

    Science.gov (United States)

    2007-01-01

    Last year proved to be another exceptional year for the European organisation for ground-based astronomy. ESO should begin the New Year with two new member states: Spain (PR 05/06) and the Czech Republic (PR 52/06). ESO PR Highlights 2006 2006 was a year of renovation and revolution in the world of planets. A new Earth-like exoplanet has been discovered (PR 03/06) using a network of telescopes from all over the world (including the Danish 1.54-m one at ESO La Silla). It is not the only child of this fruitful year: thanks to the combined use of ESO's Very Large Telescope (VLT) and La Silla instruments, a surprising system of twin giant exoplanets was found (PR 29/06), and a trio of Neptune-like planets hosted by a nearby star were identified (PR 18/06). These results open new perspectives on the search for habitable zones and on the understanding of the mechanism of planet formation. The VISIR instrument on the VLT has been providing unique information to answer this last question, by supplying a high resolution view of a planet-forming disc (PR 36/06). There are not only new members in the planets' register: during the General Assembly of the International Astronomical Union held in Prague (Czech Republic), it was decided that Pluto is not a planet anymore but a 'dwarf planet'. Whatever its status, Pluto still has a satellite, Charon, whose radius and density have been measured more accurately by observing a rare occultation from different sites, including Cerro Paranal (PR 02/06). The scientific community dedicated 2006 to the great physicist James Clerk Maxwell (it was the 175th anniversary of the birth): without his electromagnetic theory of light, none of the astonishing discoveries of modern physics could have been achieved. Nowadays we can look at distant galaxies in great detail: the GIRAFFE spectrograph on the VLT revealed that galaxies 6 billion years ago had the same amount of dark matter relative to stars than nowadays (PR 10/06), while SINFONI gave an

  16. Er talesprog en medieteknologi?

    DEFF Research Database (Denmark)

    Tække, Jesper

    2013-01-01

    motiver og viden, må give mening til hvad, der meddeles og selektere en forståelse (Luhmann 2000a). Formålet med og berettigelsen for medieteori er ud fra Marshall McLuhans (1967) devise, om at the medium is the message, at sammenligne, hvad det betyder for menneske og samfund, at der kommunikeres i ét...... herunder forklares funktionelt i et evolutionært perspektiv på den sociale udvikling for at opklare, (1) hvordan sproget er udviklet, og (2a) hvordan det virker i bevidsthed og (2b) i kommunikation. Via denne øvelse tegnes et billede af sprogteknologiens kommunikative rum, af det scope, talesproget giver...

  17. Facebook er internettet nu

    DEFF Research Database (Denmark)

    Tække, Jesper

    2014-01-01

    Den store vision for world wide web var, at alle kunne få ubegrænset adgang til alverdens information. www var mangfoldigt og anarkistisk. I dag er der rigtig mange, der kun bruger nettet til at være på Facebook. Hvad bruger Facebook det til? Og hvad gør det ved vores udsyn?......Den store vision for world wide web var, at alle kunne få ubegrænset adgang til alverdens information. www var mangfoldigt og anarkistisk. I dag er der rigtig mange, der kun bruger nettet til at være på Facebook. Hvad bruger Facebook det til? Og hvad gør det ved vores udsyn?...

  18. Influence of Levonorgestrel on the endometrium VEGF, ER, PR and serum hormone of patients with anovulatory functional bleeding%左炔诺孕酮对无排卵型功能失调性子宫出血患者子宫内膜血管内皮细胞生长因子、雌激素受体、孕激素受体及血清激素的影响

    Institute of Scientific and Technical Information of China (English)

    陈秀琴; 郑安桔

    2013-01-01

    Objective To study the influence of Levonorgestrel for the endometrium vascular endothelial growth factors (VEGF), estrogen receptor (ER), progesterone receptor (PR) and serum hormone of patients with anovulatory functional bleeding. Methods 28 patients with anovulatory functional bleeding treated with Marvelon from March 2011 to July 2012 were the control group, and 28 cases treated with Levonorgestrel at the same time were the observation group, then the endometrium gland and stromal VEGF, ER, PR, serum hormone before and after treatment for 1, 3 and 6 months and other related items of two groups were compared. Results The endometrium gland and stromal VEGF of observation group after treatment for 1, 3 and 6 months were 64.29%, 71.43%, 78.57% and 57.14%, 64.29%, 75.00%, serum progesterone (P) were (3.49±0.26) ng/mL, (3.80±0.29) ng/mL and (3.93±0.32) ng/mL, and they were higher than those of control group, ER, PR and serum estradiol (E2) were lower than those of control group, there were all signifi-cant differences (all P 0.05), while the endometrial thickness was smaller than that of control group, hemoglobin level was higher than that of control group, PBAC scores were all lower than those of control group, incidence of ad-verse reactions was lower than that of control group, there were all significant differences (all P < 0.05). Conclusion The influence of Levonorgestrel for the endometrium VEGF, ER, PR and serum E2, P of patients with anovulatory functional bleeding is great, and it effectively improve other related indexes of disease.%目的 探讨左炔诺孕酮对无排卵型功能失调性子宫出血(功血)患者子宫内膜血管内皮细胞生长因子(VEGF)、雌激素受体(ER)、孕激素受体(PR)及血清激素的影响.方法 选取2011年3月~2012年7月采用妈富隆进行治疗的28例无排卵型功血患者为对照组,同期采用左炔诺孕酮进行治疗的28例患者为观察组.将两组患者治疗前与治疗后1、3、6个

  19. Hvis er lovene?

    DEFF Research Database (Denmark)

    Holm, Isak Winkel

    2015-01-01

    Hvem konstituerer det politiske fællesskab, som laver lovene? Hvad sker der, når folket ikke kender lovene, eller ikke findes værdige til dem? Hvis folket udfordrede adelens love før i tiden, er det måske migranterne, der udfordrer europæernes love og konventioner i dag. Man kan med fordel gå til...... Franz Kafka for at forstå hvordan....

  20. Hvis er Himmeriget?

    DEFF Research Database (Denmark)

    Holst, Søren

    2007-01-01

    Udtrykket "de fattige i ånden", som kendes fra Bjergprædikenen i Matthæusevangeliet, forekommer også i to af Dødehavsrullerne. Artiklen undersøger disse tekster og argumenterer for, at udtrykket ikke betegner en særligt "åndelig" fattigdom, men derimod de konkret økonomisk fattige, som er "af ånd...

  1. Han er her endnu

    DEFF Research Database (Denmark)

    Bonde, Lisbeth

    2012-01-01

    Interview med den kinesiske aktivist og billedkunstner Ai Weiwei, der sad fængslet i 81 dage i 2011. Hans pas er stadig (i februar 2014) inddraget af myndighederne, så han kan ikke forlade landet, selv om han har betalt en bøde på 13 mio. kr. for ”skatteunddragelse”. Både i sin kunst og i sine...

  2. Hvad er meningen

    DEFF Research Database (Denmark)

    Mølbæk, Anders Klitgaard

    2014-01-01

    Dette projekt er det afsluttende projekt i Masteruddannelsen IKT og læring og handler om, hvad der giver mening for studerende i fagområdet produktkendskab, og hvordan vi kan redesigne et undervisningsforløb, hvor vi inddrager IKT- støttende læringselementer. Projektet tager udgangspunkt i et...... om et fag i høj grad konstrueres gennem social interaktion mellem studerende. Vi konkluderer, at det er vigtig at medtænke skabelsen af mening i design af læringsaktiviteter. Vi konkluderer ligeledes at brugen af metaforer og fortællinger er væsentlige sproglige elementer, der med fordel kan...... inddrages i design af digitale læremidler og læringsaktiviteter. I anden del af projektet opstiller vi et koncept for redesign af fagområdet med fokus på en foretagsomheds didaktik samt en model for design af læringsaktiviteter, som illustreres med tre konkrete eksempler, inspireret af et koncept af Gilly...

  3. Hvad er meningen?

    DEFF Research Database (Denmark)

    Stisen, Bente Kjærgaard; Mølbæk, Anders Klitgaard; Bayer, Inge Marie

    2014-01-01

    Dette projekt er det afsluttende projekt i Masteruddannelsen IKT og læring og handler om, hvad der giver mening for studerende i fagområdet produktkendskab, og hvordan vi kan redesigne et undervisningsforløb, hvor vi inddrager IKT- støttende læringselementer. Projektet tager udgangspunkt i et...... om et fag i høj grad konstrueres gennem social interaktion mellem studerende. Vi konkluderer, at det er vigtig at medtænke skabelsen af mening i design af læringsaktiviteter. Vi konkluderer ligeledes at brugen af metaforer og fortællinger er væsentlige sproglige elementer, der med fordel kan...... inddrages i design af digitale læremidler og læringsaktiviteter. I anden del af projektet opstiller vi et koncept for redesign af fagområdet med fokus på en foretagsomheds didaktik samt en model for design af læringsaktiviteter, som illustreres med tre konkrete eksempler, inspireret af et koncept af Gilly...

  4. Factors associated with estrogen receptors-alpha (ER-alpha) and -beta (ER-beta) and progesterone receptor abundance in obese and non obese pre- and post-menopausal women.

    Science.gov (United States)

    Meza-Muñoz, Dalia Edith; Fajardo, Martha E; Pérez-Luque, Elva Leticia; Malacara, Juan Manuel

    2006-06-01

    There is scarce information about the factors associated with estrogen receptors (ER) at menopause. In 113 volunteers pre- and post-menopausal healthy women, grouped as with and without obesity, estrogen receptors-alpha and -beta, and progesterone receptor (PR) were measured by immunohistochemistry in skin punch biopsies obtained from the external gluteal area. In pre-menopausal women, biopsies and a blood sample were performed between days 7 and 14 of the cycle. Serum hormone levels were measured by immunoradiometric assay or radioimmunoassay. After menopause, ER and PR amounts decreased significantly. At pre-menopause, obese women had lower PR levels than non obese (P<.006). In the post-menopausal group, obese women showed higher ER-alpha (P<.03) and ER-beta (P<.02) levels than the non obese group. In the analysis of factors associated with the amount of steroid receptors for the total group, log[ER-alpha], log[ER-beta], and log[PR] were associated with age (P<.002, <.005, and <.004, respectively). The log[ER-alpha] was also associated with log[FSH] (P<.0008); meanwhile, the log[PR] showed a marginal correlation with log[FSH]. In pre-menopausal women no factor associated with any of the three receptors was found. In post-menopausal women log[ER-alpha] was associated with log[estrone] and log[DHEAS] (P<.003 and <.02, respectively). log[PR] was associated with BMI (P<.002), years since menopause (P<.05), and log[DHEAS] (P<.003). We concluded that ER and PR diminish sharply at post-menopause. At this stage the amount of receptors depends on several factors such as BMI, years since menopause, and androgen precursors.

  5. Censor ved de faglige prøver i erhvervsuddannelserne

    DEFF Research Database (Denmark)

    Guldberg, Stig; Jørgensen, Claus Bo

    Denne publikation, som indeholder en filmsekvens og et arbejdshæfte, kan vejlede censorer og skuemestre ved faglige prøver i erhvervsuddannelserne. Arbejdshæftet indeholder både gode råd og henvisninger til de relevante regler for prøver og bedømmelser. Filmsekvensen er på cirka ni minutter og me...... kopieres. Materialet kan frit downloades og installeres på den enkelte skoles intranet....

  6. Noninvasiv prænatal test er et gennembrud inden for prænatal screening

    DEFF Research Database (Denmark)

    Hornstrup, Louise Stig; Ambye, Louise; Sørensen, Steen;

    2016-01-01

    Non-invasive prenatal testing (NIPT) using cell-free fetal DNA from the peripheral blood of the pregnant woman has become a possibility within recent years, but is not yet implemented in Denmark. NIPT has proven to be very efficient in the screening for especially trisomi 21. This article...

  7. Noninvasiv prænatal test er et gennembrud inden for prænatal screening

    DEFF Research Database (Denmark)

    Hornstrup, Louise Stig; Ambye, Louise; Sørensen, Steen;

    2015-01-01

    Non-invasive prenatal testing (NIPT) using cell-free fetal DNA from the peripheral blood of the pregnant woman has become a possibility within recent years, but is not yet implemented in Denmark. NIPT has proven to be very efficient in the screening for especially trisomi 21. This article...

  8. 29 August 2013 - J.-F. Jauslin, Directeur de l’Office fédéral de la culture (OFC) Ambassadeur suisse auprès de l’UNESCO et de l’OIF au 1er septembre 2013 Confédération suisse visite le centre visiteurs de l’expérience ATLAS ainsi que la caverne expérimentale d'ATLAS avec P. Jenny, ancien Porte-parole d'ATLAS. M. Bona, Conseiller du Directeur général pour les relations avec les Organisations internationales présent tout au long.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    29 August 2013 - J.-F. Jauslin, Directeur de l’Office fédéral de la culture (OFC) Ambassadeur suisse auprès de l’UNESCO et de l’OIF au 1er septembre 2013 Confédération suisse visite le centre visiteurs de l’expérience ATLAS ainsi que la caverne expérimentale d'ATLAS avec P. Jenny, ancien Porte-parole d'ATLAS. M. Bona, Conseiller du Directeur général pour les relations avec les Organisations internationales présent tout au long.

  9. Prøvningsmetoder for isoleringsmateriale som underlag for tagpap = Testing methods for insulating material used as underlay for roofing felt

    DEFF Research Database (Denmark)

    Nicolajsen, Asta

    Rapporten redegør for UEAtc's prøvningsmetoder til vurdering af isoleringsmaterialer som underlag for tagpap. Disse metoder er udviklet ud fra de beskrevne isoleringstykkelser, som anvendes i Centraleuropa. I rapporten vurderes i hvilket omfang prøvningsmetoderne også er egnede for danske forhold....

  10. Entangled research(ers)

    DEFF Research Database (Denmark)

    Brøgger, Katja; Staunæs, Dorthe

    into the world and being situated and attuned to it in specific ways through interest, fear, boredom or something else. Combing concepts from philosophy as well as psychology, the material and the affective turn allow us to rethink and elaborate on well-known discussions on qualitative research, representation......This paper takes up the challenges of analyzing how empirical knowledge is created when the research(ers) are always already “thrown into the world” (Heidegger) and thereby affectively “intra-act” (Barad) with and ‘perform’ the empirical knowledge. ‘ ‘Thrownness’ is Heidegger’s way of expressing...

  11. Skoleelevers faglige præstationer præges markant af klassen

    DEFF Research Database (Denmark)

    Middelboe, Vibe Abildtrup

    2016-01-01

    Lærerfravær og disciplin i klassen er udslagsgivende faktorer, når man vil forstå, hvorfor nogle klasser klarer sig dårligere end andre på samme skole. Det viser en ny københavnsk undersøgelse, der også slår fast, at relationen mellem lærer og elev påvirker de faglige præstationer....

  12. Evaluación de los efectos del tratamiento con tadalafilo sobre las funciones cerebrales, neurológicas y bioquímicas en pacientes con hiperplasia benigna de próstata y disfunción eréctil

    OpenAIRE

    Ordoño Domínguez, Felipe

    2015-01-01

    EVALUACION DE LOS EFECTOS DEL TRATAMIENTO CON TADALAFILO SOBRE LAS FUNCIONES CEREBRALES, NEUROLOGICAS Y BIOQUIMICAS EN PACIENTES CON HBP Y DISFUNCION ERECTIL. La hiperplasia prostática benigna (HBP) es una de las enfermedades benignas más comunes en el hombre y puede derivar en una hipertrofia benigna de la próstata, en una obstrucción benigna de la próstata y/o en síntomas del tracto urinario inferior (STUI). La hiperplasia benigna de próstata suele estar asociada habitualmente con disfu...

  13. Unraveling the role of ER stress inhibitors in the context of metabolic diseases.

    Science.gov (United States)

    Sarvani, Chodisetty; Sireesh, Dornadula; Ramkumar, Kunka Mohanram

    2017-02-22

    ER stress is provoked by the accumulation of unfolded and misfolded proteins in the ER lumen leading to perturbations in ER homeostasis. ER stress activates a signaling cascade called the Unfolded Protein Response (UPR) which triggers a set of transcriptional and translational events that restore ER homeostasis, promoting cell survival and adaptation. If this adaptive response fails, a terminal UPR program commits such cells to apoptosis. Existing preclinical and clinical evidence testify that prolonged ER stress escalates the risk of several metabolic disorders including diabetes, obesity and dyslipidemia. There have been considerable efforts to develop small molecules that are capable of ameliorating ER stress. Few naturally occurring and synthetic molecules have already been demonstrated for their efficacy in abrogating ER stress in both in vitro and in vivo models of metabolic disorders. This review provides a broad overview of the molecular mechanisms of inhibition of ER stress and its association with various metabolic diseases.

  14. Rouw mag er zijn

    Directory of Open Access Journals (Sweden)

    Marlieke Moors

    2015-12-01

    Full Text Available ABSTRACTGrieving is allowedGrief is a human experience. Every form of loss shapes you into the human being you are today. Contrary to what earlier, unproven grief models postulate, grief does not have an end point. That is, bereavement does not have to be completely processed, but it should be integrated into someone’s life. The outdated grief models were often interpreted and used in a normative way, which led to a normative standard model. This portraits the belief that every mourner would experience similar symptoms and would go through a fixed pattern of phases. However, the updated vision emphasizes the individual and unique process of coping with loss: norms concerning grief should be banned. By means of literature research, interviews with professionals and personal experiences, it became clear that finding an equilibrium between restoration-orientated and loss-orientated coping styles is most beneficial. An important aspect in finding this balance is meaningfulness. Furthermore, the ability to bear a loss and to adapt accordingly are important components. Lastly, attaching significance to a loss is a constructive way of integrating the loss into one’s life. The death of a loved one should therefore not be forgotten or tucked away. After all, grief is the price we pay for love. SAMENVATTINGRouw mag er zijnRouw is een menselijke ervaring en elk verlies vormt je als mens. Rouw heeft, in tegenstelling tot wat de verouderde, niet bewezen rouwmodellen beweren, geen eindpunt. Verlies hoeft namelijk niet verwerkt te worden, maar moet juist geïntegreerd worden in iemands leven. De verouderde rouwmodellen zijn vaak normatief opgevat en toegepast, waaruit een normatief standaardmodel is ontstaan. Daarbij werd gedacht dat elke rouwende dezelfde symptomen zou vertonen en het rouwproces volgens vaste fasen zou verlopen. Binnen de vernieuwde visie wordt er juist van uitgegaan dat elk individu een unieke manier van reageren op rouw heeft. Er zou

  15. Hvorfor samtalen ikke er demokratiets sjæl ikke er demokratiets sjæl

    Directory of Open Access Journals (Sweden)

    Michael Schudson

    2001-09-01

    Full Text Available Medie- og kommunikationsforskningen har ofte opfattet samtalen, der føres ansigt-til-ansigt, som en hjørnesten i den demokratiske proces. Denne opfattelse stammer bl.a. fra medieforskeren James Carey, der selv har været inspireret af den amerikanske filosof John Dewey. I den- ne artikel præsenterer Michael Schudson en kritik af, hvad han kalder den romantiske forestilling om samtalen. Samtalen ansigt-til-ansigt har været lige så meget i højsædet i aristokratier som i demokratier, og der er faktisk to distinkte og modsatte idealer for samtale: den selskabelige samtale og den problemløsende samtale. Samtalen, der tjener demo- kratiet, er ikke kendetegnet ved egalitarisme, men ved normstyrethed og offentlighed, ikke ved spontanitet men ved høflighed, og ikke ved dens forrang eller overlegenhed i forhold til trykte medier, radio eller tv, men ved dens nødvendige afhængighed af dem. Der argumenteres for, at institutioner og demokratiske normer giver anledning til demokratiske samtaler, snarere end at samtalens iboende demokrati fører til politisk demokratiske normer og institutioner. Artiklen er oversat af Stig Hjarvard.

  16. Hvorfor samtalen ikke er demokratiets sjæl ikke er demokratiets sjæl

    Directory of Open Access Journals (Sweden)

    Michael Schudson

    2001-09-01

    Full Text Available Medie- og kommunikationsforskningen har ofte opfattet samtalen, der føres ansigt-til-ansigt, som en hjørnesten i den demokratiske proces. Denne opfattelse stammer bl.a. fra medieforskeren James Carey, der selv har været inspireret af den amerikanske filosof John Dewey. I den- ne artikel præsenterer Michael Schudson en kritik af, hvad han kalder den romantiske forestilling om samtalen. Samtalen ansigt-til-ansigt har været lige så meget i højsædet i aristokratier som i demokratier, og der er faktisk to distinkte og modsatte idealer for samtale: den selskabelige samtale og den problemløsende samtale. Samtalen, der tjener demo- kratiet, er ikke kendetegnet ved egalitarisme, men ved normstyrethed og offentlighed, ikke ved spontanitet men ved høflighed, og ikke ved dens forrang eller overlegenhed i forhold til trykte medier, radio eller tv, men ved dens nødvendige afhængighed af dem. Der argumenteres for, at institutioner og demokratiske normer giver anledning til demokratiske samtaler, snarere end at samtalens iboende demokrati fører til politisk demokratiske normer og institutioner. Artiklen er oversat af Stig Hjarvard.

  17. Leo den Store: Prædiken på st. Laurentius' dag

    DEFF Research Database (Denmark)

    Willert, Niels

    1992-01-01

    Oversættelse af prædiken holdt af den kendte pave Leo den store i 400-tallet. Prædikenen forholder sig til Sankt Laurentius og hans martyrdød.Oversættelsen er et bidrag i en samling af prædikener fra oldkirken. Bogen har en indledning ved professor dr.theol. Christian Thodberg.......Oversættelse af prædiken holdt af den kendte pave Leo den store i 400-tallet. Prædikenen forholder sig til Sankt Laurentius og hans martyrdød.Oversættelsen er et bidrag i en samling af prædikener fra oldkirken. Bogen har en indledning ved professor dr.theol. Christian Thodberg....

  18. 9. klasse prøve i idræt 2015

    DEFF Research Database (Denmark)

    Bertelsen, Katrine; Bruun, Tine Hedegaard; Halling, Anders

    Denne rapport er et resultat af en undersøgelse af de første erfaringer med idræt som prøvefag i folkeskolen. Rapporten er blevet til ud fra en ambition om at kvalificere arbejdet med 9. klasse prøven i idræt. Undersøgelsen er blevet lavet i et samarbejde mellem UC SYD/Det nationale Videncenter K...... KOSMOS, Forsknings- og Innovationscenter for Idræt, Bevægelse og Læring (FIIBL) og VIA University College. I rapporten 9. klasse prøve i idræt er der tre artikler, der afdækker hvert deres perspektiv - et ministerielt, et lærer og et elevperspektiv....

  19. Humor er en alvorlig sag

    DEFF Research Database (Denmark)

    Søltoft, Pia

    2016-01-01

    I modsætning til ironi er humor for Kierkegaard fællesskabsgivende – ironikeren hævder sig selv, men humoristen har sympati med den, man ler med. Humor er hos Kierkegaard udtryk for, at humoristen forliger sig med tilværelsen og dens luner, og dermed grænser humoren hos Kierkegaard op til det...

  20. Vores vidensgrundlag er i fare

    DEFF Research Database (Denmark)

    Madsen, Mia; Nøhr, Ellen Aagaard; Olsen, Jørn;

    2013-01-01

    Databrug: Forskningsfrihed er lige så vigtig for demokratiet som pressefrihed, og det er bekymrende, at lovgivningen fra EU lægger langt større begrænsninger på brug af data for forskere end for politikere. Der har i den seneste tid været en omfattede debat i medierne om nytten af vores dataregis...

  1. Kollegaerne er den nye chef

    DEFF Research Database (Denmark)

    Fugl, Marie

    2008-01-01

    Den tid, hvor chefen var den, der delte skideballer ud, er slut. Rollen som 'bad cop' er overtaget af kollegateamet, der med hård hånd sørger for, at den enkelte yder sin del. Udgivelsesdato: November...

  2. RNA er jo bare matematik!

    DEFF Research Database (Denmark)

    Blaavand, Jakob Lindblad

    2011-01-01

    Hvordan kan man kurere sygdomme med matematiske geometriske strukturer? Det kan man i princippet, hvis de geometriske figurer er RNA-molekyler, og sygdommen skyldes syge gener.......Hvordan kan man kurere sygdomme med matematiske geometriske strukturer? Det kan man i princippet, hvis de geometriske figurer er RNA-molekyler, og sygdommen skyldes syge gener....

  3. Er fortællingen om det frigjorte individ altid sand?

    DEFF Research Database (Denmark)

    Trolle, Astrid Krabbe

    2016-01-01

    Selvom individualisering er en stærk tendens, bør der foretages mere præcise analyser af, hvordan religiøs individualisering leves og bruges i forskellige sociale grupper, mener religionssociolog og ph.d.-studerende Astrid Krabbe Trolle......Selvom individualisering er en stærk tendens, bør der foretages mere præcise analyser af, hvordan religiøs individualisering leves og bruges i forskellige sociale grupper, mener religionssociolog og ph.d.-studerende Astrid Krabbe Trolle...

  4. Computerbasiert prüfen [Computer-based Assessment

    Directory of Open Access Journals (Sweden)

    Frey, Peter

    2006-08-01

    Full Text Available [english] Computer-based testing in medical education offers new perspectives. Advantages are sequential or adaptive testing, integration of movies or sound, rapid feedback to candidates and management of web-based question banks. Computer-based testing can also be implemented in an OSCE examination. In e-learning environments formative self-assessment are often implemented and gives helpful feedbacks to learners. Disadvantages in high-stake exams are the high requirements as well for the quality of testing (e.g. standard setting as additionally for the information technology and especially for security. [german] Computerbasierte Prüfungen im Medizinstudium eröffnen neue Möglichkeiten. Vorteile solcher Prüfungen liegen im sequentiellen oder adaptiven Prüfen, in der Integration von Bewegtbildern oder Ton, der raschen Auswertung und zentraler Verwaltung der Prüfungsfragen via Internet. Ein Einsatzgebiet mit vertretbarem Aufwand sind Prüfungen mit mehreren Stationen wie beispielsweise die OSCE-Prüfung. Computerbasierte formative Selbsttests werden im Bereiche e-learning häufig angeboten. Das hilft den Lernenden ihren Wissensstand besser einzuschätzen oder sich mit den Leistungen anderer zu vergleichen. Grenzen zeigen sich bei den summativen Prüfungen beim Prüfungsort, da zuhause Betrug möglich ist. Höhere ärztliche Kompetenzen wie Untersuchungstechnik oder Kommunikation eigenen sich kaum für rechnergestützte Prüfungen.

  5. Marknadskommunikation i förändring : En studie i hur PR-byråers marknadskommunikation har förändrats under första decenniet på 2000-talet med bakgrund i sociala medier

    OpenAIRE

    Holm, Gabriella; Larsson, Chrisfoffer

    2012-01-01

    Title: Market Communication in transformation Authors: Gabriella Holm and Christoffer Larsson Purpose/Aim: The purpose of this paper is to examine how market communication at PR-firms in Sweden has changed over the first decade of the 21-century. In 2007 social media expanded on the Swedish market. This had implications for the way we are looking at communication and therefore also the PR business and how they are operating. The aim with this paper is to see how social media have affected mar...

  6. Control of mechatronic systems using electrorheological fluids; ER ryutai wo mochiita mekatoronikusu kiki no seigyo

    Energy Technology Data Exchange (ETDEWEB)

    Furusho, J. [The Univ. of Electric Communications, Tokyo (Japan)

    1995-09-10

    ER fluids (electrorheological fluids) are fluids whose rheological properties vary due to an electric field, and at the present, its development is being vigorously carried forward with the objective of its application to various mechanical systems. The ER fluids which are the objects for its development are two kinds, namely ER suspensions and homogeneous fluids using liquid crystals. Concerning the ER suspensions, its study started from the latter half of 1940`s, but the history of studying the homogeneous ER fluids is short. In this article, comparison is made between the ER suspensions and the homogeneous ER fluids. Regarding the comparison in their application fields, several differences are enumerated including that the response time of the ER suspensions to the change of the electric field is considerably faster than the homogeneous fluids using liquid crystals. As examples of the application of the ER suspensions, ER valves, application to automobiles, ER dampers, vibration control of structures, and ER clutches are shown and likewise, as examples of the application of the homogeneous ER fluids, robot arm control, dampers, etc.. Also its application to robotics is described. 51 refs., 8 figs., 1 tab.

  7. ER stress and cancer: The FOXO forkhead transcription factor link.

    Science.gov (United States)

    Alasiri, Glowi; Fan, Lavender Yuen-Nam; Zona, Stefania; Goldsbrough, Isabella Galeno; Ke, Hui-Ling; Auner, Holger Werner; Lam, Eric Wing-Fai

    2017-05-29

    The endoplasmic reticulum (ER) is a cellular organelle with central roles in maintaining proteostasis due to its involvement in protein synthesis, folding, quality control, distribution and degradation. The accumulation of misfolded proteins in the ER lumen causes 'ER stress' and threatens overall cellular proteostasis. To restore ER homeostasis, cells evoke an evolutionarily conserved adaptive signalling and gene expression network collectively called the 'unfolded protein response (UPR)', a complex biological process which aims to restore proteostasis. When ER stress is overwhelming and beyond rectification, the normally pro-survival UPR can shift to induce cell termination. Emerging evidence from mammalian, fly and nematode worm systems reveals that the FOXO Forkhead proteins integrate upstream ER stress and UPR signals with the transcriptional machinery to decrease translation, promote cell survival/termination and increase the levels of ER-resident chaperones and of ER-associated degradation (ERAD) components to restore ER homeostasis. The high rates of protein synthesis/translation associated with cancer cell proliferation and metabolism, as well as mutations resulting in aberrant proteins, also induce ER stress and the UPR. While the pro-survival side of the UPR underlies its ability to sustain and promote cancers, its apoptotic functions can be exploited for cancer therapies by offering the chance to 'flick the proteostatic switch'. To this end, further studies are required to fully reevaluate the roles and regulation of these UPR signalling molecules, including FOXO proteins and their targets, in cancer initiation and progression as well as the effects on inhibiting their functions in cancer cells. This information will help to establish these UPR signalling molecules as possible therapeutic targets and putative biomarkers in cancers. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Min mentor er min voksenven

    DEFF Research Database (Denmark)

    Kaiser, Birte

    2009-01-01

    En artikel i bogen: 6 belysninger af vejledning, brydninger, forståelser & praksis. Artiklen er et sammendrag af en diskursanalyse fra 2008 fra projetrapporten: Ind under huden, www.vejledning.net...

  9. Forenklingens fire F'er

    DEFF Research Database (Denmark)

    Bentzen, Tina Øllgaard

    2017-01-01

    At fjerne styring er det, man ofte forbinder med afbureaukratisering, men det er ikke tilstrækkeligt, når man vil gå fra flotte ambitioner til en styring, som reelt opleves enklere. For at forenkle må man også forandre, forankre og fastholde styring, og det må ske i et samspil mellem de aktører, ...

  10. ER stress induced by ionising radiation in IEC-6 cells.

    Science.gov (United States)

    Zhang, Bo; Wang, Yan; Pang, Xueli; Su, Yongping; Ai, Guoping; Wang, Tao

    2010-06-01

    Ionising radiation (IR) can evoke a series of biochemical events inside the cell. However, whether IR can directly induce endoplasmic reticulum (ER) stress is not clear. In our previous study, we found that there might be a causative link between IR and ER stress. In this study, we further characterised the type of ER stress induced by IR. Rat intestinal epithelial cells IEC-6 were irradiated at a dose of 10 Gy, and total RNA and proteins were harvested at indicated time points. The mRNA and protein expression of immunoglobulin heavy chain binding protein (BiP) and glucose regulated protein 94 (GRP94) was detected along with proteins associated with ER stress signal pathways. Our results indicated that IR induced up-regulation of ER stress marker including BiP and GRP94 at protein and mRNA levels in IEC-6 cells. Increased phosphorylation of eukaryotic translation initiation factor 2 (eIF2alpha) and induced mRNA splicing of X-box binding protein 1 (XBP1) suggested that PERK (interferon-induced double-stranded RNA-activated protein kinase (PRKR) -like endoplasmic reticulum kinase) and IRE1 (inositol requirement 1) signal transduction pathways were involved in this kind of ER stress. However, the active form of activating transcription factor 6 (ATF6) did not change significantly in irradiated cells, which suggested that the ATF6 pathway was not involved. Thus, we concluded that IR could induce moderate ER stress directly in IEC-6 cells.

  11. Er frække reklamer forførende - eller bare spildte anstrengelser?

    DEFF Research Database (Denmark)

    Hermansen, Judy

    2009-01-01

      Det er blevet mere og mere almindeligt at reklamebranchen prøver kræfter med konventionerne for at tiltrække sig opmærksomhed. De kontroversielle reklameudformninger giver da også ofte noget presseomtale, men hvordan virker de egentlig i forhold til forbrugerne?   I undersøgelsen af, hvordan ko...

  12. The Effectiveness of Core ER Principles

    Science.gov (United States)

    Jeon, Eun-Young; Day, Richard R.

    2015-01-01

    This discussion piece continues the discussion forum on extensive reading (ER) from the April 2015 issue of "Reading in a Foreign Language." In that forum, a number of the discussions were concerned with the principles of ER (Day & Bamford, 2002) in implementing ER. Our discussion also concerns the principles; we examine ER programs…

  13. Hvad er normen for isoleucin til grise?

    DEFF Research Database (Denmark)

    Nørgaard, Jan Værum

    2011-01-01

    Efter introduktionen af aminosyren L-valin er isoleucin kommet i fokus, når der optimeres foder til svin. Men der er usikkerhed omkring normen for isoleucin.......Efter introduktionen af aminosyren L-valin er isoleucin kommet i fokus, når der optimeres foder til svin. Men der er usikkerhed omkring normen for isoleucin....

  14. ER-12-1 completion report

    Energy Technology Data Exchange (ETDEWEB)

    Russell, C.E.; Gillespie, D.; Cole, J.C.; Drellack, S.L. [and others

    1996-12-01

    The objective of drillhole ER-12-1 was to determine the hydrogeology of paleozoic carbonate rocks and of the Eleana Formation, a regional aquitard, in an area potentially downgradient from underground nuclear testing conducted in nearby Rainier Mesa. This objective was addressed through the drilling of well ER-12-1 at N886,640.26 E640,538.85 Nevada Central Coordinates. Drilling of the 1094 m (3588 ft) well began on July 19, 1991 and was completed on October 17, 1991. Drilling problems included hole deviation and hole instability that prevented the timely completion of this borehole. Drilling methods used include rotary tri-cone and rotary hammer drilling with conventional and reverse circulation using air/water, air/foam (Davis mix), and bentonite mud. Geologic cuttings and geophysical logs were obtained from the well. The rocks penetrated by the ER-12-1 drillhole are a complex assemblage of Silurian, Devonian, and Mississippian sedimentary rocks that are bounded by numerous faults that show substantial stratigraphic offset. The final 7.3 m (24 ft) of this hole penetrated an unusual intrusive rock of Cretaceous age. The geology of this borehole was substantially different from that expected, with the Tongue Wash Fault encountered at a much shallower depth, paleozoic rocks shuffled out of stratigraphic sequence, and the presence of an altered biotite-rich microporphyritic igneous rock at the bottom of the borehole. Conodont CAI analyses and rock pyrolysis analyses indicate that the carbonate rocks in ER-12-1, as well as the intervening sheets of Eleana siltstone, have been thermally overprinted following movement on the faults that separate them. The probable source of heat for this thermal disturbance is the microporphyritic intrusion encountered at the bottom of the hole, and its age establishes that the major fault activity must have occurred prior to 102.3+0.5 Ma (middle Cretaceous).

  15. ER stress, autophagy, and RNA viruses

    Directory of Open Access Journals (Sweden)

    Jia-Rong eJheng

    2014-08-01

    Full Text Available Endoplasmic reticulum (ER stress is a general term for representing the pathway by which various stimuli affect ER functions. ER stress induces the evolutionarily conserved signaling pathways, called the unfolded protein response (UPR, which compromises the stimulus and then determines whether the cell survives or dies. In recent years, ongoing research has suggested that these pathways may be linked to the autophagic response, which plays a key role in the cell’s response to various stressors. Autophagy performs a self-digestion function, and its activation protects cells against certain pathogens. However, the link between the UPR and autophagy may be more complicated. These two systems may act dependently, or the induction of one system may interfere with the other. Experimental studies have found that different viruses modulate these mechanisms to allow them to escape the host immune response or, worse, to exploit the host’s defense to their advantage; thus, this topic is a critical area in antiviral research. In this review, we summarize the current knowledge about how RNA viruses, including influenza virus, poliovirus, coxsackievirus, enterovirus 71, Japanese encephalitis virus, hepatitis C virus, and dengue virus, regulate these processes. We also discuss recent discoveries and how these will produce novel strategies for antiviral treatment.

  16. Schools Need the PR's.

    Science.gov (United States)

    Palmer, George C.

    1980-01-01

    PR is an acronym standing for philosophic revitalization, planned reactions, proper rhetoric, and personal responsibility. A look at these PRs can challenge school personnel's thinking toward meeting the goals of the district. (Author/MLF)

  17. Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells.

    Science.gov (United States)

    Su, Dan; Fu, Xiaoying; Fan, Songqing; Wu, Xiao; Wang, Xin-Xin; Fu, Liya; Dong, Xue-Yuan; Ni, Jianping Jenny; Fu, Li; Zhu, Zhengmao; Dong, Jin-Tang

    2012-03-01

    Whereas estrogen-estrogen receptor α (ER) signaling plays an important role in breast cancer growth, it is also necessary for the differentiation of normal breast epithelial cells. How this functional conversion occurs, however, remains unknown. Based on a genome-wide sequencing study that identified mutations in several breast cancer genes, we examined some of the genes for mutations, expression levels, and functional effects on cell proliferation and tumorigenesis. We present the data for C1orf64 or ER-related factor (ERRF) from 31 cell lines and 367 primary breast cancer tumors. Whereas mutation of ERRF was infrequent (1 of 79 or 1.3%), its expression was up-regulated in breast cancer, and the up-regulation was more common in lower-stage tumors. In addition, increased ERRF expression was significantly associated with ER and/or progesterone receptor (PR) positivity, which was still valid in human epidermal growth factor receptor 2 (HER2)-negative tumors. In ER-positive tumors, ERRF expression was inversely correlated with HER2 status. Furthermore, higher ERRF protein expression was significantly associated with better disease-free survival and overall survival, particularly in ER- and/or PR-positive and HER2-negative tumors (luminal A subtype). Functionally, knockdown of ERRF in two ER-positive breast cancer cell lines, T-47D and MDA-MB-361, suppressed cell growth in vitro and tumorigenesis in xenograft models. These results suggest that ERRF plays a role in estrogen-ER-mediated growth of breast cancer cells and could, thus, be a potential therapeutic target.

  18. Finske skove, tuba’er og The Tuning of the World

    DEFF Research Database (Denmark)

    Gram, Nina

    2011-01-01

    ) refererer i deres arbejde kontinuerligt til forskellige ’oprindelige’ eller ’naturlige’ lydmiljøer fundet hos enten en stamme i New Guinea (Feld) eller i forskellige landsbyer i Europa. Der er altså tilsyneladende en forestilling om og forkærlighed for de ’naturlige’ lyde, og denne præference er som regel......- og paperpræsentationer var alle meget interessante, og et gennemgående tema var lydens betydning for vores fysiske og psykiske velbefindende. I løbet af konferencen var der dog ikke mange bud på konkrete modeller for, hvordan vi kan designe, modellere eller justere aktuelle lydmiljøer, så de giver...

  19. Altsaa det er det nationale!

    DEFF Research Database (Denmark)

    Tøndborg, Britta

    2005-01-01

    Det er ikke alle kunstkanoner, der opstår eller tager form som et resultat af en langsom proces i lighed med darwinistisk evolution; en evolution, som sker over tid, og hvor de stærkeste kunstværker gradvist skiller sig ud fra de mindre betydelige. En kanon udgør ikke altid en retrospektiv opgøre...

  20. Viden er vigtigere end mavefornemmelser

    DEFF Research Database (Denmark)

    Holm, Claus

    2007-01-01

    Vi lever i et vidensamfund og i et demokratisk samfund, men det er ikke godt nok. Ifølge lektor Anne-Marie Eggert Olsen ville livet være mindre bekymrende, hvis deltagerdemokratiet fyldte mindre og fornuftsbaseret politik mere....

  1. Krumme tæer

    DEFF Research Database (Denmark)

    Frederiksen, Mons Bissenbakker

    2013-01-01

    skamforskningen og forskellige postkoloniale og crip-teoretiske kritikker af samme. Hensigten er at pege på et analytisk udgangspunkt, som gør det muligt at gribe de subversive muligheder i skam uden samtidig at miste blikket for skammens ekskluderende funktioner: Nogle subjekter kan øjensynligt ikke undslippe...

  2. Physiological ER Stress Mediates the Differentiation of Fibroblasts.

    Directory of Open Access Journals (Sweden)

    Shinsuke Matsuzaki

    Full Text Available Recently, accumulating reports have suggested the importance of endoplasmic reticulum (ER stress signaling in the differentiation of several tissues and cells, including myoblasts and osteoblasts. Secretory cells are easily subjected to ER stress during maturation of their secreted proteins. Skin fibroblasts produce and release several proteins, such as collagens, matrix metalloproteinases (MMPs, the tissue inhibitors of metalloproteinases (TIMPs and glycosaminoglycans (GAGs, and the production of these proteins is increased at wound sites. Differentiation of fibroblasts into myofibroblasts is one of the key factors for wound healing and that TGF-β can induce fibroblast differentiation into myofibroblasts, which express α-smooth muscle actin. Well-differentiated myofibroblasts show increased production of collagen and TGF-β, and bring about wound healing. In this study, we examined the effects of ER stress signaling on the differentiation of fibroblasts, which is required for wound healing, using constitutively ER stress-activated primary cultured fibroblasts. The cells expressed positive α-smooth muscle actin signals without TGF-β stimulation compared with control fibroblasts. Gel-contraction assays suggested that ER stress-treated primary fibroblasts caused stronger shrinkage of collagen gels than control cells. These results suggest that ER stress signaling could accelerate the differentiation of fibroblasts to myofibroblasts at injured sites. The present findings may provide important insights for developing therapies to improve wound healing.

  3. Parcerias e práticas sexuais de jovens homossexuais no Rio de Janeiro Sexual partners and practices of young homosexuals in Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Luís Felipe Rios

    2003-01-01

    Full Text Available Este artigo aborda aspectos da organização das vidas eróticas de homens jovens com práticas homossexuais. As reflexões apresentadas são embasadas em pesquisa etnográfica, que envolveu observações em espaços de homossociabilidade e entrevistas com jovens com práticas homossexuais do Rio de Janeiro. Por meio da apresentação de cenas eróticas próprias a um circuito homoerótico e pelo resgate das trajetórias sexuais de jovens com práticas homossexuais, este artigo busca apontar implicações dos roteiros eróticos e padrões de parcerias sexuais identificados para a saúde sexual desses mesmos jovens. O texto chama especial atenção para relatos sobre o surgimento de interações eróticas na infância, em parcerias interetárias e intergeracionais que se prolongam até a idade adulta, em uma crescente tendência a ir se invertendo (busca por parceiros mais novos em termos etários. O artigo sugere que tais fenômenos necessitam ser mais bem entendidos por possuírem sérias implicações para o planejamento de ações em saúde sexual para jovens (e crianças com práticas homossexuais.This article focuses on the organization of the erotic lives of young men who engage in homosexual practices. The reflections presented here are based on ethnographic research including observation in places of homosociability and interviews with young men in Rio de Janeiro reporting homosexual practices. By presenting erotic scenes pertaining to a homoerotic circuit and recording the sexual trajectories of young men engaging in homosexual practices, the article seeks to identify the implications of the observed erotic scripts and sex-partner patterns for the sexual health of these individuals. The text calls special attention to reports concerning the emergence of different forms of erotic interaction in childhood, as well as cross-age and crossgenerational partnerships that extend into adulthood, with a growing trend toward seeking younger

  4. Endoplasmic Reticulum (ER) Stress and Endocrine Disorders

    Science.gov (United States)

    Ariyasu, Daisuke; Yoshida, Hiderou; Hasegawa, Yukihiro

    2017-01-01

    The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the “unfolded protein response” (UPR), which protects cells from ER stress. Cells undergo apoptosis when ER stress exceeds the capacity of the UPR, which has been revealed to cause human diseases. Although neurodegenerative diseases are well-known ER stress-related diseases, it has been discovered that endocrine diseases are also related to ER stress. In this review, we focus on ER stress-related human endocrine disorders. In addition to diabetes mellitus, which is well characterized, several relatively rare genetic disorders such as familial neurohypophyseal diabetes insipidus (FNDI), Wolfram syndrome, and isolated growth hormone deficiency type II (IGHD2) are discussed in this article. PMID:28208663

  5. Endoplasmic Reticulum (ER) Stress and Endocrine Disorders.

    Science.gov (United States)

    Ariyasu, Daisuke; Yoshida, Hiderou; Hasegawa, Yukihiro

    2017-02-11

    The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the "unfolded protein response" (UPR), which protects cells from ER stress. Cells undergo apoptosis when ER stress exceeds the capacity of the UPR, which has been revealed to cause human diseases. Although neurodegenerative diseases are well-known ER stress-related diseases, it has been discovered that endocrine diseases are also related to ER stress. In this review, we focus on ER stress-related human endocrine disorders. In addition to diabetes mellitus, which is well characterized, several relatively rare genetic disorders such as familial neurohypophyseal diabetes insipidus (FNDI), Wolfram syndrome, and isolated growth hormone deficiency type II (IGHD2) are discussed in this article.

  6. ER stress and hepatic lipid metabolism

    Directory of Open Access Journals (Sweden)

    Huiping eZhou

    2014-05-01

    Full Text Available The endoplasmic reticulum (ER is an important player in regulating protein synthesis and lipid metabolism. Perturbation of ER homeostasis, referred as ER stress, has been linked to numerous pathological conditions, such as inflammation, cardiovascular diseases and metabolic disorders. The liver plays a central role in regulating nutrient and lipid metabolism. Accumulating evidence implicates that ER stress disrupts lipid metabolism and induces hepatic lipotoxicity. Here, we review the major ER stress signaling pathways, how ER stress contributes to the dysregulation of hepatic lipid metabolism, and the potential causative mechanisms of ER stress in hepatic lipotoxicity. Understanding the role of ER stress in hepatic metabolism may lead to the identification of new therapeutic targets for metabolic diseases.

  7. Endoplasmic Reticulum (ER Stress and Endocrine Disorders

    Directory of Open Access Journals (Sweden)

    Daisuke Ariyasu

    2017-02-01

    Full Text Available The endoplasmic reticulum (ER is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the “unfolded protein response” (UPR, which protects cells from ER stress. Cells undergo apoptosis when ER stress exceeds the capacity of the UPR, which has been revealed to cause human diseases. Although neurodegenerative diseases are well-known ER stress-related diseases, it has been discovered that endocrine diseases are also related to ER stress. In this review, we focus on ER stress-related human endocrine disorders. In addition to diabetes mellitus, which is well characterized, several relatively rare genetic disorders such as familial neurohypophyseal diabetes insipidus (FNDI, Wolfram syndrome, and isolated growth hormone deficiency type II (IGHD2 are discussed in this article.

  8. PR-PR: cross-platform laboratory automation system.

    Science.gov (United States)

    Linshiz, Gregory; Stawski, Nina; Goyal, Garima; Bi, Changhao; Poust, Sean; Sharma, Monica; Mutalik, Vivek; Keasling, Jay D; Hillson, Nathan J

    2014-08-15

    To enable protocol standardization, sharing, and efficient implementation across laboratory automation platforms, we have further developed the PR-PR open-source high-level biology-friendly robot programming language as a cross-platform laboratory automation system. Beyond liquid-handling robotics, PR-PR now supports microfluidic and microscopy platforms, as well as protocol translation into human languages, such as English. While the same set of basic PR-PR commands and features are available for each supported platform, the underlying optimization and translation modules vary from platform to platform. Here, we describe these further developments to PR-PR, and demonstrate the experimental implementation and validation of PR-PR protocols for combinatorial modified Golden Gate DNA assembly across liquid-handling robotic, microfluidic, and manual platforms. To further test PR-PR cross-platform performance, we then implement and assess PR-PR protocols for Kunkel DNA mutagenesis and hierarchical Gibson DNA assembly for microfluidic and manual platforms.

  9. PR-PR: Cross-Platform Laboratory Automation System

    Energy Technology Data Exchange (ETDEWEB)

    Linshiz, G; Stawski, N; Goyal, G; Bi, CH; Poust, S; Sharma, M; Mutalik, V; Keasling, JD; Hillson, NJ

    2014-08-01

    To enable protocol standardization, sharing, and efficient implementation across laboratory automation platforms, we have further developed the PR-PR open-source high-level biology-friendly robot programming language as a cross-platform laboratory automation system. Beyond liquid-handling robotics, PR-PR now supports microfluidic and microscopy platforms, as well as protocol translation into human languages, such as English. While the same set of basic PR-PR commands and features are available for each supported platform, the underlying optimization and translation modules vary from platform to platform. Here, we describe these further developments to PR-PR, and demonstrate the experimental implementation and validation of PR-PR protocols for combinatorial modified Golden Gate DNA assembly across liquid-handling robotic, microfluidic, and manual platforms. To further test PR-PR cross-platform performance, we then implement and assess PR-PR protocols for Kunkel DNA mutagenesis and hierarchical Gibson DNA assembly for microfluidic and manual platforms.

  10. The hyperplastic phenotype in PR-A and PR-B transgenic mice: lessons on the role of estrogen and progesterone receptors in the mouse mammary gland and breast cancer.

    Science.gov (United States)

    Sampayo, Rocio; Recouvreux, Sol; Simian, Marina

    2013-01-01

    Progesterone receptor (PR) belongs to the superfamily of steroid receptors and mediates the action of progesterone in its target tissues. In the mammary gland, in particular, PR expression is restricted to the luminal epithelial cell compartment. The generation of estrogen receptor-α (ER) and PR knockout mice allowed the specific characterization of the roles of each of these in mammary gland development: ER is critical for ductal morphogenesis, whereas PR has a key role in lobuloalveolar differentiation. To further study the role PR isoforms have in mammary gland biology, transgenic mice overexpressing either the "A" (PR-A) or the "B" (PR-B) isoforms of PR were generated. Overexpression of the A isoform of PR led to increased side branching, multilayered ducts, loss of basement membrane integrity, and alterations in matrix metalloproteinase activation in the mammary gland. Moreover, levels of TGFβ1 and p21 were diminished and those of cyclin D1 increased. Interestingly, the phenotype was counteracted by antiestrogens, suggesting that ER is essential for the manifestation of the hyperplasias. Mice overexpressing the B isoform of PR had limited ductal growth but retained the ability to differentiate during pregnancy. Levels of latent and active TGFβ1 were increased compared to PR-A transgenics. The phenotypes of these transgenic mice are further discussed in the context of the impact of progesterone on mammary stem cells and breast cancer. We conclude that an adequate balance between the A and B isoforms of PR is critical for tissue homeostasis. Future work to further understand the biology of PR in breast biology will hopefully lead to new and effective preventive and therapeutic alternatives for patients.

  11. Nordisk Fjer-sagen er fortsat aktuel

    DEFF Research Database (Denmark)

    Langsted, Lars Bo

    2004-01-01

    I sidste uge satte Højesteret definitivt punktum efter 14 år. Men sagens setup er klassisk for økonomisk kriminalitet, og derfor er den god at tage ved lære af.......I sidste uge satte Højesteret definitivt punktum efter 14 år. Men sagens setup er klassisk for økonomisk kriminalitet, og derfor er den god at tage ved lære af....

  12. Common cytotoxic chemotherapeutics induce epithelial-mesenchymal transition (EMT) downstream of ER stress.

    Science.gov (United States)

    Shah, Parag P; Dupre, Tess V; Siskind, Leah J; Beverly, Levi J

    2017-04-04

    Endoplasmic reticulum (ER) in eukaryotes is a main organelle involved in a wide variety of functions including calcium storage, lipid biosynthesis, protein folding and protein transport. Disruption of ER homeostasis leads to ER stress and activation of the unfolded protein response (UPR). We and others have previously found that ER stress induces EMT in different cellular systems. Induction of ER stress with chemical modulators of ER homeostasis was sufficient to activate an EMT-like state in all cellular systems tested. Here, we provide evidence for the first time demonstrating that ER stress induces EMT that is neither cancer cell specific nor cell-type specific. In addition, we observed that chemotherapeutic drugs commonly used to treat patients also activate ER stress that is concomitant with activation of an EMT-like state. Interestingly, we find that following removal of ER stress, partial EMT characteristics still persist indicating that ER stress induced EMT is a long-term effect. Induction of mesenchymal characteristics, following chemotherapeutics treatment may be involved in providing cancer stemness and invasiveness in the cellular system. Interestingly, we find that mice treated with cisplatin have elevated level of ER stress and EMT markers in multiple tissues including lung, liver and kidneys. Furthermore, increased ER stress, as demonstrated by increased Bip, Chop, PDI, Ero1α and IRE1, and EMT, as demonstrated by increased Vimentin and Snail, is a hallmark of primary lung adenocarcinoma samples from patients. These observations have potential clinical relevance because overexpression of ER stress and EMT markers might contribute to chemoresistance and poor survival of lung adenocarcinoma patients.

  13. Sport er hverken sundt eller social

    DEFF Research Database (Denmark)

    Andersen, Tem Frank

    2013-01-01

    Jeg deler ikke Lasch og Kayser Nielsens konklusioner, selvom jeg er meget enig i, at sport er dirty business. Min analyse peger i den retning, at sporten i sin organiserede form ikke er eller kan fungere som leverandør af nogen ”pakkeløsning”. Men sport kan sagtens bidrage med brudstykker til nog...

  14. Den sproglige leg er super fly

    DEFF Research Database (Denmark)

    Just, Sine Nørholm

    2013-01-01

    Man kan rappe om alt. I hvert fald hvis man er Marvelous Mosell. I spændingsfeltet mellem fiktion og virkelighed skaber Mosell sin persona i et forjættende 80' er-univers der på en og samme tid er vildt overdrevet og helt autentisk....

  15. Lifestyle und Engagement – Jugendkultur in den „langen“ 1960er Jahren

    Directory of Open Access Journals (Sweden)

    Pascal Eitler

    2007-07-01

    Full Text Available Detlef Siegfried präsentiert mit dem vorliegenden Band eine ebenso umfangreiche wie fundierte Analyse der westdeutschen Jugendkultur in den “langen“ 1960er Jahren. Er nimmt insbesondere das Verhältnis von Konsum und Politik in den Blick und kann zeigen, dass es gerade die ambivalente Verbindung von Lifestyle und Engagement war, welche die viel zitierte Dynamik dieses Zeitraums charakterisierte. Als Ausgangspunkt dient ihm dabei der sich wandelnde Umgang mit Musik: Musik als Ausdruck, aber auch als Motor einer sich verändernden Jugendkultur.

  16. Jordkvalitetskriterier for PAH'er

    DEFF Research Database (Denmark)

    Carlsen, Lars

    2009-01-01

    For to år siden forhøjede Miljøstyrelsen den administrativt fastsatte grænseværdi for polycycliske hydrocarboner (PAH’er) i jord med en faktor 3, hvilket i praksis betød at en række grunde, der tidligere var klassifi ceret som forurenede, nu ikke klassifi ceres sådan. Den hidtidige og den nye...

  17. Jordkvalitetskriterier for PAH'er

    DEFF Research Database (Denmark)

    Carlsen, Lars

    2009-01-01

    For to år siden forhøjede Miljøstyrelsen den administrativt fastsatte grænseværdi for polycycliske hydrocarboner (PAH’er) i jord med en faktor 3, hvilket i praksis betød at en række grunde, der tidligere var klassifi ceret som forurenede, nu ikke klassifi ceres sådan. Den hidtidige og den nye met...

  18. Hvad er en god skolestart?

    DEFF Research Database (Denmark)

    Knoop, Hans Henrik

    2007-01-01

    Skolestarten er et vendepunkt i børns liv. For et par generationer siden var det at komme i 1. klasse det helt væsentlige skift. I de senere år har stort set alle børn imidlertid gået i børnehaveklasse og inden da i børnehave. Når aktiviteterne i børnehaveklassen og senere i 1. klasse slutter...

  19. Foregribende sorg er ikke forebyggende

    DEFF Research Database (Denmark)

    Nielsen, Mette Kjærgaard; Thomsen, Kia Toft; Jensen, Anders Bonde

    2017-01-01

    Baggrund: Betydningen af pårørendes sorgsymptomer før tid, tidligere kaldet foregribende sorg, er uklar. Materiale og metode: En landsdækkende spørgeskemaundersøgelse af 3635 pårørende til patienter med terminaltilskud i 2012. Resultater: Mange symptomer på sorg før død havde sammenhæng med kompl...

  20. Genome-wide association studies identify four ER negative–specific breast cancer risk loci

    Science.gov (United States)

    Garcia-Closas, Montserrat; Couch, Fergus J; Lindstrom, Sara; Michailidou, Kyriaki; Schmidt, Marjanka K; Brook, Mark N; orr, Nick; Rhie, Suhn Kyong; Riboli, Elio; Feigelson, Heather s; Le Marchand, Loic; Buring, Julie E; Eccles, Diana; Miron, Penelope; Fasching, Peter A; Brauch, Hiltrud; Chang-Claude, Jenny; Carpenter, Jane; Godwin, Andrew K; Nevanlinna, Heli; Giles, Graham G; Cox, Angela; Hopper, John L; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Dicks, Ed; Howat, Will J; Schoof, Nils; Bojesen, Stig E; Lambrechts, Diether; Broeks, Annegien; Andrulis, Irene L; Guénel, Pascal; Burwinkel, Barbara; Sawyer, Elinor J; Hollestelle, Antoinette; Fletcher, Olivia; Winqvist, Robert; Brenner, Hermann; Mannermaa, Arto; Hamann, Ute; Meindl, Alfons; Lindblom, Annika; Zheng, Wei; Devillee, Peter; Goldberg, Mark S; Lubinski, Jan; Kristensen, Vessela; Swerdlow, Anthony; Anton-Culver, Hoda; Dörk, Thilo; Muir, Kenneth; Matsuo, Keitaro; Wu, Anna H; Radice, Paolo; Teo, Soo Hwang; Shu, Xiao-Ou; Blot, William; Kang, Daehee; Hartman, Mikael; Sangrajrang, Suleeporn; Shen, Chen-Yang; Southey, Melissa C; Park, Daniel J; Hammet, Fleur; Stone, Jennifer; Veer, Laura J Van’t; Rutgers, Emiel J; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Peto, Julian; Schrauder, Michael G; Ekici, Arif B; Beckmann, Matthias W; Silva, Isabel dos Santos; Johnson, Nichola; Warren, Helen; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Marme, Federick; Schneeweiss, Andreas; Sohn, Christof; Truong, Therese; Laurent-Puig, Pierre; Kerbrat, Pierre; Nordestgaard, Børge G; Nielsen, Sune F; Flyger, Henrik; Milne, Roger L; Perez, Jose Ignacio Arias; Menéndez, Primitiva; Müller, Heiko; Arndt, Volker; Stegmaier, Christa; Lichtner, Peter; Lochmann, Magdalena; Justenhoven, Christina; Ko, Yon-Dschun; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Greco, Dario; Heikkinen, Tuomas; Ito, Hidemi; Iwata, Hiroji; Yatabe, Yasushi; Antonenkova, Natalia N; Margolin, Sara; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Balleine, Rosemary; Tseng, Chiu-Chen; Van Den Berg, David; Stram, Daniel O; Neven, Patrick; Dieudonné, Anne-Sophie; Leunen, Karin; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Peterlongo, Paolo; Peissel, Bernard; Bernard, Loris; Olson, Janet E; Wang, Xianshu; Stevens, Kristen; Severi, Gianluca; Baglietto, Laura; Mclean, Catriona; Coetzee, Gerhard A; Feng, Ye; Henderson, Brian E; Schumacher, Fredrick; Bogdanova, Natalia V; Labrèche, France; Dumont, Martine; Yip, Cheng Har; Taib, Nur Aishah Mohd; Cheng, Ching-Yu; Shrubsole, Martha; Long, Jirong; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Kauppila, Saila; knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Tollenaar, Robertus A E M; Seynaeve, Caroline M; Kriege, Mieke; Hooning, Maartje J; Van den Ouweland, Ans M W; Van Deurzen, Carolien H M; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Balasubramanian, Sabapathy P; Cross, Simon S; Reed, Malcolm W R; Signorello, Lisa; Cai, Qiuyin; Shah, Mitul; Miao, Hui; Chan, Ching Wan; Chia, Kee Seng; Jakubowska, Anna; Jaworska, Katarzyna; Durda, Katarzyna; Hsiung, Chia-Ni; Wu, Pei-Ei; Yu, Jyh-Cherng; Ashworth, Alan; Jones, Michael; Tessier, Daniel C; González-Neira, Anna; Pita, Guillermo; Alonso, M Rosario; Vincent, Daniel; Bacot, Francois; Ambrosone, Christine B; Bandera, Elisa V; John, Esther M; Chen, Gary K; Hu, Jennifer J; Rodriguez-gil, Jorge L; Bernstein, Leslie; Press, Michael F; Ziegler, Regina G; Millikan, Robert M; Deming-Halverson, Sandra L; Nyante, Sarah; Ingles, Sue A; Waisfisz, Quinten; Tsimiklis, Helen; Makalic, Enes; Schmidt, Daniel; Bui, Minh; Gibson, Lorna; Müller-Myhsok, Bertram; Schmutzler, Rita K; Hein, Rebecca; Dahmen, Norbert; Beckmann, Lars; Aaltonen, Kirsimari; Czene, Kamila; Irwanto, Astrid; Liu, Jianjun; Turnbull, Clare; Rahman, Nazneen; Meijers-Heijboer, Hanne; Uitterlinden, Andre G; Rivadeneira, Fernando; Olswold, Curtis; Slager, Susan; Pilarski, Robert; Ademuyiwa, Foluso; Konstantopoulou, Irene; Martin, Nicholas G; Montgomery, Grant W; Slamon, Dennis J; Rauh, Claudia; Lux, Michael P; Jud, Sebastian M; Bruning, Thomas; Weaver, Joellen; Sharma, Priyanka; Pathak, Harsh; Tapper, Will; Gerty, Sue; Durcan, Lorraine; Trichopoulos, Dimitrios; Tumino, Rosario; Peeters, Petra H; Kaaks, Rudolf; Campa, Daniele; Canzian, Federico; Weiderpass, Elisabete; Johansson, Mattias; Khaw, Kay-Tee; Travis, Ruth; Clavel-Chapelon, Françoise; Kolonel, Laurence N; Chen, Constance; Beck, Andy; Hankinson, Susan E; Berg, Christine D; Hoover, Robert N; Lissowska, Jolanta; Figueroa, Jonine D

    2013-01-01

    Estrogen receptor (ER)-negative tumors represent 20–30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry1. The etiology2 and clinical behavior3 of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition4. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P = 2.1 × 10−12 and LGR6, P = 1.4 × 10−8), 2p24.1 (P = 4.6 × 10−8) and 16q12.2 (FTO, P = 4.0 × 10−8), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers. PMID:23535733

  1. When Supply Does Not Meet Demand-ER Stress and Plant Programmed Cell Death

    Directory of Open Access Journals (Sweden)

    Brett eWilliams

    2014-06-01

    Full Text Available The endoplasmic reticulum (ER is the central organelle in the eukaryotic secretory pathway. The ER functions in protein synthesis and maturation and is crucial for proper maintenance of cellular homeostasis and adaptation to adverse environments. Acting as a cellular sentinel, the ER is exquisitely sensitive to changing environments principally via the ER quality control machinery. When perturbed, ER-stress triggers a tightly regulated and highly conserved, signal transduction pathway known as the unfolded protein response (UPR that prevents the dangerous accumulation of unfolded/misfolded proteins. In situations where excessive UPR activity surpasses threshold levels, cells deteriorate and eventually trigger programmed cell death (PCD as a way for the organism to cope with dysfunctional or toxic signals. The programmed cell death that results from excessive ER stress in mammalian systems contributes to several important diseases including hypoxia, neurodegeneration and diabetes. Importantly, hallmark features and markers of cell death that are associated with ER stress in mammals are also found in plants. In particular, there is a common, conserved set of chaperones that modulate ER cell death signalling. Here we review the elements of plant cell death responses to ER stress and note that an increasing number of plant-pathogen interactions are being identified in which the host ER is targeted by plant pathogens to establish compatibility.

  2. Genome-wide association studies identify four ER negative-specific breast cancer risk loci.

    Science.gov (United States)

    Garcia-Closas, Montserrat; Couch, Fergus J; Lindstrom, Sara; Michailidou, Kyriaki; Schmidt, Marjanka K; Brook, Mark N; Orr, Nick; Rhie, Suhn Kyong; Riboli, Elio; Feigelson, Heather S; Le Marchand, Loic; Buring, Julie E; Eccles, Diana; Miron, Penelope; Fasching, Peter A; Brauch, Hiltrud; Chang-Claude, Jenny; Carpenter, Jane; Godwin, Andrew K; Nevanlinna, Heli; Giles, Graham G; Cox, Angela; Hopper, John L; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Dicks, Ed; Howat, Will J; Schoof, Nils; Bojesen, Stig E; Lambrechts, Diether; Broeks, Annegien; Andrulis, Irene L; Guénel, Pascal; Burwinkel, Barbara; Sawyer, Elinor J; Hollestelle, Antoinette; Fletcher, Olivia; Winqvist, Robert; Brenner, Hermann; Mannermaa, Arto; Hamann, Ute; Meindl, Alfons; Lindblom, Annika; Zheng, Wei; Devillee, Peter; Goldberg, Mark S; Lubinski, Jan; Kristensen, Vessela; Swerdlow, Anthony; Anton-Culver, Hoda; Dörk, Thilo; Muir, Kenneth; Matsuo, Keitaro; Wu, Anna H; Radice, Paolo; Teo, Soo Hwang; Shu, Xiao-Ou; Blot, William; Kang, Daehee; Hartman, Mikael; Sangrajrang, Suleeporn; Shen, Chen-Yang; Southey, Melissa C; Park, Daniel J; Hammet, Fleur; Stone, Jennifer; Veer, Laura J Van't; Rutgers, Emiel J; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Peto, Julian; Schrauder, Michael G; Ekici, Arif B; Beckmann, Matthias W; Dos Santos Silva, Isabel; Johnson, Nichola; Warren, Helen; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Marme, Federick; Schneeweiss, Andreas; Sohn, Christof; Truong, Therese; Laurent-Puig, Pierre; Kerbrat, Pierre; Nordestgaard, Børge G; Nielsen, Sune F; Flyger, Henrik; Milne, Roger L; Perez, Jose Ignacio Arias; Menéndez, Primitiva; Müller, Heiko; Arndt, Volker; Stegmaier, Christa; Lichtner, Peter; Lochmann, Magdalena; Justenhoven, Christina; Ko, Yon-Dschun; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Greco, Dario; Heikkinen, Tuomas; Ito, Hidemi; Iwata, Hiroji; Yatabe, Yasushi; Antonenkova, Natalia N; Margolin, Sara; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Balleine, Rosemary; Tseng, Chiu-Chen; Berg, David Van Den; Stram, Daniel O; Neven, Patrick; Dieudonné, Anne-Sophie; Leunen, Karin; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Peterlongo, Paolo; Peissel, Bernard; Bernard, Loris; Olson, Janet E; Wang, Xianshu; Stevens, Kristen; Severi, Gianluca; Baglietto, Laura; McLean, Catriona; Coetzee, Gerhard A; Feng, Ye; Henderson, Brian E; Schumacher, Fredrick; Bogdanova, Natalia V; Labrèche, France; Dumont, Martine; Yip, Cheng Har; Taib, Nur Aishah Mohd; Cheng, Ching-Yu; Shrubsole, Martha; Long, Jirong; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Kauppila, Saila; Knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Tollenaar, Robertus A E M; Seynaeve, Caroline M; Kriege, Mieke; Hooning, Maartje J; van den Ouweland, Ans M W; van Deurzen, Carolien H M; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Balasubramanian, Sabapathy P; Cross, Simon S; Reed, Malcolm W R; Signorello, Lisa; Cai, Qiuyin; Shah, Mitul; Miao, Hui; Chan, Ching Wan; Chia, Kee Seng; Jakubowska, Anna; Jaworska, Katarzyna; Durda, Katarzyna; Hsiung, Chia-Ni; Wu, Pei-Ei; Yu, Jyh-Cherng; Ashworth, Alan; Jones, Michael; Tessier, Daniel C; González-Neira, Anna; Pita, Guillermo; Alonso, M Rosario; Vincent, Daniel; Bacot, Francois; Ambrosone, Christine B; Bandera, Elisa V; John, Esther M; Chen, Gary K; Hu, Jennifer J; Rodriguez-Gil, Jorge L; Bernstein, Leslie; Press, Michael F; Ziegler, Regina G; Millikan, Robert M; Deming-Halverson, Sandra L; Nyante, Sarah; Ingles, Sue A; Waisfisz, Quinten; Tsimiklis, Helen; Makalic, Enes; Schmidt, Daniel; Bui, Minh; Gibson, Lorna; Müller-Myhsok, Bertram; Schmutzler, Rita K; Hein, Rebecca; Dahmen, Norbert; Beckmann, Lars; Aaltonen, Kirsimari; Czene, Kamila; Irwanto, Astrid; Liu, Jianjun; Turnbull, Clare; Rahman, Nazneen; Meijers-Heijboer, Hanne; Uitterlinden, Andre G; Rivadeneira, Fernando; Olswold, Curtis; Slager, Susan; Pilarski, Robert; Ademuyiwa, Foluso; Konstantopoulou, Irene; Martin, Nicholas G; Montgomery, Grant W; Slamon, Dennis J; Rauh, Claudia; Lux, Michael P; Jud, Sebastian M; Bruning, Thomas; Weaver, Joellen; Sharma, Priyanka; Pathak, Harsh; Tapper, Will; Gerty, Sue; Durcan, Lorraine; Trichopoulos, Dimitrios; Tumino, Rosario; Peeters, Petra H; Kaaks, Rudolf; Campa, Daniele; Canzian, Federico; Weiderpass, Elisabete; Johansson, Mattias; Khaw, Kay-Tee; Travis, Ruth; Clavel-Chapelon, Françoise; Kolonel, Laurence N; Chen, Constance; Beck, Andy; Hankinson, Susan E; Berg, Christine D; Hoover, Robert N; Lissowska, Jolanta; Figueroa, Jonine D; Chasman, Daniel I; Gaudet, Mia M; Diver, W Ryan; Willett, Walter C; Hunter, David J; Simard, Jacques; Benitez, Javier; Dunning, Alison M; Sherman, Mark E; Chenevix-Trench, Georgia; Chanock, Stephen J; Hall, Per; Pharoah, Paul D P; Vachon, Celine; Easton, Douglas F; Haiman, Christopher A; Kraft, Peter

    2013-04-01

    Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P = 2.1 × 10(-12) and LGR6, P = 1.4 × 10(-8)), 2p24.1 (P = 4.6 × 10(-8)) and 16q12.2 (FTO, P = 4.0 × 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.

  3. Characterisation of the Vitis vinifera PR10 multigene family

    Science.gov (United States)

    2010-01-01

    Background Genes belonging to the pathogenesis related 10 (PR10) group have been studied in several plant species, where they form multigene families. Until now, such an analysis has not been performed in Vitis vinifera, although three different PR10 genes were found to be expressed under pathogen attack or abiotic stress, and during somatic embryogenesis induction. We used the complete genome sequence for characterising the whole V. vinifera PR10 gene family. The expression of candidate genes was studied in various non-treated tissues and following somatic embryogenesis induction by the auxin 2,4-D. Results In addition to the three V. vinifera PR10 genes already described, namely VvPR10.1, VvPR10.2 and VvPR10.3, fourteen different PR10 related sequences were identified. Showing high similarity, they form a single cluster on the chromosome 5 comprising three pseudogenes. The expression of nine different genes was detected in various tissues. Although differentially expressed in non-treated plant organs, several genes were up-regulated in tissues treated with 2,4-D, as expected for PR genes. Conclusions PR10 genes form a multigene family in V. vinifera, as found in birch, apple or peach. Seventeen closely related PR10 sequences are arranged in a tandem array on the chromosome 5, probably reflecting small-scale duplications during evolution. Various expression patterns were found for nine studied genes, highlighting functional diversification. A phylogenetic comparison of deduced proteins with PR10 proteins of other plants showed a characteristic low intraspecific variability. Particularly, a group of seven close tandem duplicates including VvPR10.1, VvPR10.2 and VvPR10.3 showed a very high similarity, suggesting concerted evolution or/and recent duplications. PMID:20727162

  4. Tank 241-ER-311, grab samples, ER311-98-1, ER311-98-2, ER311-98-3 analytical results for the final report

    Energy Technology Data Exchange (ETDEWEB)

    FULLER, R.K.

    1999-02-24

    This document is the final report for catch tank 241-ER-311 grab samples. Three grab samples ER311-98-1, ER311-98-2 and ER311-98-3 were taken from East riser of tank 241-ER-311 on August 4, 1998 and received by the 222-S Laboratory on August 4, 1998. Analyses were performed in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) (Sasaki, 1998)and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) (Mulkey and Miller, 1997). The analytical results are presented in the data summary report (Table 1). No notification limits were exceeded.

  5. Test og prøvelser

    DEFF Research Database (Denmark)

    Test i forskellige former og afskygninger spiller i dag en markant rolle indenfor mange forskellige områder i samfundet. De bliver anvendt til at evaluere og bedømme børn, unge og voksne i forskellige kontekster og med forskellige formål og konsekvenser. I mange tilfælde er der tale om test, hvis...... udfald – direkte eller indirekte - vil kunne få vidtrækkende følger for dem, der testes. Test kan sætte sig spor livet igennem og udsætte de testede for prøvelser, idet de påvirker deres selvopfattelser og udstikker bestemte livsbaner og muligheder. Med afsæt i uddannelsesområdet sætter denne bog fokus...... på test i historisk og nutidig belysning. Den behandler spørgsmål som: Hvordan kom test ind i feltet? Hvilke test anvendes? Hvem tester man? Hvorfor vil man gerne teste? Hvad er de direkte og indirekte sociale konsekvenser af at anvende test? Besvarelsen af disse spørgsmål kan på den ene side bidrage...

  6. Neutron Scattering from fcc Pr and Pr3Tl

    DEFF Research Database (Denmark)

    Birgeneau, R. J.; Als-Nielsen, Jens Aage; Bucher, E.

    1972-01-01

    Elastic-neutron-scattering measurements on the singlet-ground-state ferromagnets fcc Pr and Pr3 Tl are reported. Both exhibit magnetic phase transitions, possibly to a simple ferromagnetic state at 20 and 11.6 °K, respectively. The transitions appear to be of second order although that in fcc Pr...... is clearly anomalous. Additional information on the inelastic scattering studies of the Γ1-Γ4 excitons in these systems is presented. dhcp Pr is also briefly discussed....

  7. Følelser er kommentarer ..

    DEFF Research Database (Denmark)

    Willert, Søren

    2007-01-01

    Artikeloverskriften præsenteres som en nøgleformulering, der kan bygge teoretisk bro mellem forståelser af det menneskelige følelsesliv som afspejlet i henholdsvis (1) evolutionspsykologisk inspireret almenpsykologi med forankring i George Herbert Mead; (2) moderne psyko-biologisk emotionsforskning...

  8. Der er liv i historie

    DEFF Research Database (Denmark)

    Poder, Anette; Müller Glibstrup, Tine; Roj Søndergaard, Anja

    I denne antologi præsenteres de første konkrete bud på, hvordan en senmoderne og konstruktivistisk historieundervisning kan tage sig ud i praksis. Der tages udgangspunk i bl.a. Bernard Eric Jensen "Historie - livsverden og fag" og Carlo Grevy "Historie og livsverden - en historiedidaktik"...

  9. Prøveprosjekt med mammografiscreeening i fire fylker; organisering og gjennomføring

    Directory of Open Access Journals (Sweden)

    Steinar Østerbø Thoresen

    2009-10-01

    Full Text Available  SAMMENDRAGRandomiserte kontrollerte studier har vist at systematisk mammografiscreening i aldersgruppen 50 til 69 årreduserer dødeligheten av brystkreft med omlag 30%. I 1994 ble det av Sosial- og helsedepartementetbesluttet å iverksette et prøveprosjekt med mammografi i fire fylker. Prosjektet omfatter kvinner i alderen50-69 år og skal pågå i fire år med to screeningrunder. Utvalgte fylker er Akershus, Hordaland, Oslo ogRogaland. Det er valgt en fylkeskommunal modell i samarbeid med Kreftregisteret, Statens helseundersøkelser(SHUS og Statens strålevern. Kreftregisteret har den nasjonale prosjektledelse, mens SHUS haransvar for invitasjoner, svarbrev samt innkjøp og drift av busser. Prosjektet skal evalueres både frakostnadsiden og informasjonsvirksomheten. Det utføres to-bilde mammografi med dobbelt tyding. Detførste driftsåret var 1996. Oppmøte før purring ligger på omlag 77%. Det er påvist 337 krefttilfeller.Svulstene er overveiende meget små og uten spredning til lymfeknuter i armhulen. Det har vært få driftsproblemer,og tiltaket er svært godt mottatt blant de inviterte kvinner.Thoresen SØ. Mammography screening in four Norwegian counties: a pilot project.Nor J Epidemiol ENGLISH SUMMARYOrganised breast cancer screening by mammography can reduce mortality from breast cancer substantially.In Norway a pilot project in four counties was startet in 1996, including 160 000 women in the age group50 to 69 years. Two-view mammography and double reading are performed. So far the attendance rate is77%, before reminders are sent to the women. The attendance rate in the mobile units are high. A total of337 breast cancers have been identified, which is seven out of 1000 screened. The positive predictive valueis 13%. The majority of the invasive tumors are small and without nodal involvement. The pilot project isscheduled for four years and will also be evaluated form the cost/benefit side.1997; 7 (2: 179-182.

  10. Préface

    Directory of Open Access Journals (Sweden)

    Marguerite Mendell

    2008-12-01

    Full Text Available C’est avec grand plaisir que je contribue la préface de ce numéro d’Interventions économiques dédié à la pertinence de la pensée de Karl Polanyi au début du 21ème siècle. Je suis très reconnaissante aux éditeurs, Diane Gabrielle Tremblay, Jean-Marc Fontan et Jean Louis Laville d’avoir pris l’initiative de préparer ce numéro pour le 11ème colloque international de l’Institut Karl Polanyi, qui correspond aussi au 20ème anniversaire de l’Institut, établi à l’Université Concordia en 1988. Interve...

  11. Kan mink smage sukkerstoffer og har mink præference for sukker?

    DEFF Research Database (Denmark)

    Schou, Toke Munk; Pertoldi, C.; Malmkvist, Jens

    Tab af evnen til at smage sukkerstoffer er forekommet hos flere arter inden for ordnen carnivora, som mink tilhører. Vi vil fremlægger resultater omkring om mink kan smage sukkerstoffer og om de har præferencer for sukker. Desuden vil vi komme med bud på hvad sådanne viden kan benyttes til i...

  12. China PR Industry Report 2005

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Background The 2005 annual survey on the PR industry in China was conducted by China International Public Relations Association(CIPRA)from January 20the to February 20th ,in order to better reflect the development of the PR service market in China,investigate trends within the PR industry,and promote its continuous development.

  13. Hvor frit er egentlig frit?

    DEFF Research Database (Denmark)

    Wierød, Lea Maria; Spang-Hanssen, Ulrik

    2011-01-01

    for en fuldstændig metronomisk tilgang, og at gennemsnittet af deres selvkontrollerede rubato lå så højt som 36%. Til sidst i artiklen viser stikprøver, foretaget hos Bartók og Debussy, at dette tal sandsynligvis er realistisk eller endog lavt målt med virkelighedens verden. This article examines whether...... of their self-controlled rubato was as high as 36%. Finally the article shows, through samples made on Bartók’s and Debussy’s playing, that this number probably is realistic or even low compared to the real world....

  14. 33 CFR 222.5 - Water control management (ER 1110-2-240).

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Water control management (ER 1110... ARMY, DEPARTMENT OF DEFENSE ENGINEERING AND DESIGN § 222.5 Water control management (ER 1110-2-240). (a... Engineers in carrying out water control management activities, including establishment of water...

  15. Snyd er ikke bare snyd

    DEFF Research Database (Denmark)

    Bay, Gina

    2008-01-01

    I efteråret 2008 lanceres hjemmesiden http://www.stopplagiat.nu/ , der skal hjælpe studerende til at undgå at plagiere. Her kan studerende bl.a. teste, om de kender reglerne for korrekt kildehåndtering godt nok. Og hvis ikke, kan de få helt konkrete redskaber til, hvordan de laver præcise kildehe...

  16. Det er på tide at begynde et dansk pilotprojekt

    DEFF Research Database (Denmark)

    Schrøder, Niels

    2008-01-01

    Det er velkendt, at CO2 kan bruges i oliefelter til at øge den mængde olie, man kan udvinde. Erfaringer fra Canada og USA viser, at brugen af CO2 i Enhanced Oil Recovery (EOR), kan øge olieudvindingsgraden med ca. ti pct. Af Energistyrelsens reseveopgørelse pr. 1. januar 2008 fremgår, at ved en...

  17. Diaspora. Somalia er ved at vågne op - overalt

    DEFF Research Database (Denmark)

    Michelsen, Anders Ib; Farah, Abdulkadir Osman; Farah Aden, Mahad;

    2013-01-01

    I efteråret 2012 fik Somalia for første gang en parlamentsformand, en præsident og en statsminister fra civilsamfundet. Den føderale regering beskyttes af ca. 18.000 afrikanske tropper fra Uganda, Kenya mv. Ekstremistiske grupper er i defensiven, men ikke nedkæmpet. 6. marts 2013 ophævede Sikkerh...... milliarder dollar om året....

  18. Metoder til måling af ketose hos søer

    DEFF Research Database (Denmark)

    Olesen, Anja Kibsgaard; Theil, Peter Kappel; Kristensen, Niels Bastian

    2010-01-01

    kunne være en laboratoriebaseret, enzymatisk målemetode på plasma eller serum. Denne metode kræver dog, at der udtages blodprøver af søerne, samt at disse prøver sendes til et laboratorium og centrifugeres. Denne form for analyse er dermed meget ressourcekrævende, og resultaterne fås ikke samme dag. Der...

  19. Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics

    Science.gov (United States)

    Bravo, Roberto; Gutierrez, Tomás; Paredes, Felipe; Gatica, Damián; Rodriguez, Andrea E.; Pedrozo, Zully; Chiong, Mario; Parra, Valentina; Quest, Andrew F.G.; Rothermel, Beverly A.; Lavandero, Sergio

    2014-01-01

    Endoplasmic reticulum (ER) stress activates an adaptive unfolded protein response (UPR) that facilitates cellular repair, however, under prolonged ER stress, the UPR can ultimately trigger apoptosis thereby terminating damaged cells. The molecular mechanisms responsible for execution of the cell death program are relatively well characterized, but the metabolic events taking place during the adaptive phase of ER stress remain largely undefined. Here we discuss emerging evidence regarding the metabolic changes that occur during the onset of ER stress and how ER influences mitochondrial function through mechanisms involving calcium transfer, thereby facilitating cellular adaptation. Finally, we highlight how dysregulation of ER–mitochondrial calcium homeostasis during prolonged ER stress is emerging as a novel mechanism implicated in the onset of metabolic disorders. PMID:22064245

  20. Kronik: Diskussion om timetal er oldnordisk

    DEFF Research Database (Denmark)

    Koefoed Hansen, Lone

    2012-01-01

    Det er ikke antallet af timer med mig, underviseren, der afgør, hvor meget en studerende lærer. Det afgørende er derimod, hvad jeg formår at anspore de studerende til at lære, mens de ikke er i samme lokale som mig, skriver kronikøren.......Det er ikke antallet af timer med mig, underviseren, der afgør, hvor meget en studerende lærer. Det afgørende er derimod, hvad jeg formår at anspore de studerende til at lære, mens de ikke er i samme lokale som mig, skriver kronikøren....

  1. En sang der er et overlevelsesudstyr

    DEFF Research Database (Denmark)

    Kock, Christian Erik J

    2015-01-01

    Fredmans Epistel N:o 81 er en af de Bellman-sange der oftest er blevet fortolket af sangere og grupper, og som synes at være blandt hans mest virkningsfulde. Hvad er dens virkning, og hvad beror den på? Læsningen her inddrager både ord og musik, lyd og tanke.......Fredmans Epistel N:o 81 er en af de Bellman-sange der oftest er blevet fortolket af sangere og grupper, og som synes at være blandt hans mest virkningsfulde. Hvad er dens virkning, og hvad beror den på? Læsningen her inddrager både ord og musik, lyd og tanke....

  2. Préface

    Science.gov (United States)

    Chardonnet, Christian; Millot, Guy

    2006-10-01

    COLOQ, réunion nationale biennale initiée en 1988 par la communauté française des lasers, de l'optique non linéaire et de l'optique quantique atteint sa neuvième édition. Depuis sa création, les objectifs poursuivis sont les suivants : - réunir la communauté française des lasers, de l'optique non linéaire et de l'optique quantique, en dépassant les clivages fondamental/appliqué, recherche publique/industrielle, - faire le point sur les avancées récentes, - permettre aux jeunes chercheurs de se rencontrer, de s'exprimer et de s'aguerrir au plan national. Le but est que tout thésard du domaine de l'optique puisse participer à COLOQ une fois durant sa thèse, présenter son travail et de se confronter à la communauté de l'optique. COLOQ9 s'est tenu, pour sa 9e édition, sur le campus universitaire de Dijon, du 7 au 9 septembre 2005. Il a été une grande réussite : nombre de participants (255) et de présentations scientifiques record (148 affiches), forte représentation des industriels (15) et participation d'environ 200 lycéens aux conférences grand public. Le nombre plus élevé que prévu d'affiches a rendu un peu serrée leur présentation : une attention particulière sera portée à cet aspect lors des prochaines éditions. Ces journées ont été consacrées à des conférences invitées données par des scientifiques de haut niveau et à des présentations sous forme d'affiches. Une plage de temps importante a été réservée pour des discussions autour des affiches. À proximité immédiate de la salle de conférence, l'exposition de matériels spécialisés pour les lasers, l'optique et l'optoélectronique a été une occasion pour les jeunes participants de découvrir et contacter les industriels et les autres grands acteurs de l'optique. L'année 2005 ayant été l'année mondiale de la physique, COLOQ9 a retenu comme thème central ”1905-2005 : à propos d'Einstein". Plusieurs grandes conférences ont été dédiées à ce th

  3. Optimal fodring af goldkøer

    DEFF Research Database (Denmark)

    Bjerre-Harpøth, Vibeke; Damgaard, Birthe Marie

    2013-01-01

    Et forsøg har vist, at køer på lavt energiniveau i goldperioden var fysiologisk sundere og havde mindre risiko for at udvikle stofskiftesygdomme end køer på et højt energiniveau. Forsøget viste også, at køer på et normalt energiniveau i senlaktationen gav mere mælk i den efterfølgende laktation e...

  4. Fanggitter beskytter svage køer

    DEFF Research Database (Denmark)

    Thomsen, Peter

    2006-01-01

    KvægInfo nr.: 1574  Dato: 13-02-2006  Forfatter: Peter Thomsen   Fanggitter beskytter svage køer Ny forskning dokumenterer, at foderbord med fanggitter giver færre aggressioner og beskytter de svage køer. Selvom køernes samlede ædetid er den samme i staldsystemer med henholdsvis fanggitter og...

  5. Prólogo

    OpenAIRE

    Rodríguez Mejía, Marcela

    2014-01-01

    Presentar esta obra me resulta tremendamente grato. Por un lado, porque el tema de las medidas cautelares en el arbitraje es una de las líneas de investigación que me han preocupado en estos últimos años, tanto desde un punto de vista doctrinal como en la práctica arbitral; y, por otro, porque la autora de esta obra guarda conmigo una estrecha relación personal, fruto de los cuatro años que hemos colaborado y trabajado conjuntamente en la Universitat de València. Para comenzar por el objeto d...

  6. Présentation

    Directory of Open Access Journals (Sweden)

    Stéphane Haber

    2010-08-01

    Full Text Available Les articles réunis dans ce dossier de la revue Astérion portent sur la première génération de la Théorie critique (dont Max Horkheimer, Walter Benjamin, Theodor W. Adorno, Herbert Marcuse et Erich Fromm constituent sans doute les figures principales. Ils se concentrent plus précisément sur les contributions philosophiques qui marquèrent la période ouverte par l’accession de Horkheimer à la direction de l’Institut de recherches sociales (1931 et close par la publication en 1944 de Dialektik...

  7. Compliance-Prüfung nach dem IDW EPS 980: Pflicht oder Kür für den Aufsichtsrat?

    OpenAIRE

    Grüninger, Stephan

    2010-01-01

    Compliance ist originär Managementaufgabe und liegt damit in der Verantwortung des Vorstandes bzw. der Geschäftsführung. Naheliegend ist, dass dem Aufsichtsrat als Überwachungsorgan eine Rolle im Rahmen der Compliance-Prüfung zukommt. Anlässlich der Veröffentlichung des Entwurfs für einen Prüfungsstandard - Grundsätze ordnungsgemäßer Prüfung von Compliance Management Systemen (IDW EPS 980) - des Instituts der Wirtschaftsprüfer sollen in diesem Beitrag drei Aspekte dieses Themas erörtert werde...

  8. Atmosfære er kropslig

    DEFF Research Database (Denmark)

    Dupont, Søren

    2008-01-01

    Det er hensigten i artiklen at vise, at begrebet atmosfære, som det er introduceret af den tyske filosof Gernot Böhme, kan fremstilles med udgangspunkt i en fænomenologisk teoridannelse, som understreger, at det væsentlige i dette perspektiv er at diskutere og forstå sammenhængene mellem menneske...... og omgivelser og selvfølgelig også sammenhængene mellem mennesker indbyrdes. Det er tit i disse relationer, at atmosfære opstår og udvikles....

  9. Optimal fodring af goldkøer

    OpenAIRE

    Bjerre-Harpøth, Vibeke; Damgaard, Birthe Marie

    2013-01-01

    Et forsøg har vist, at køer på lavt energiniveau i goldperioden var fysiologisk sundere og havde mindre risiko for at udvikle stofskiftesygdomme end køer på et højt energiniveau. Forsøget viste også, at køer på et normalt energiniveau i senlaktationen gav mere mælk i den efterfølgende laktation end køer, der fik reduceret foderets energiniveau i senlaktationen.

  10. Geometric calibration of ERS satellite SAR images

    DEFF Research Database (Denmark)

    Mohr, Johan Jacob; Madsen, Søren Nørvang

    2001-01-01

    Geometric calibration of the European Remote Sensing (ERS) Satellite synthetic aperture radar (SAR) slant range images is important in relation to mapping areas without ground reference points and also in relation to automated processing. The relevant SAR system parameters are discussed...... on a seven-year ERS-1 and a four-year ERS-2 time series, the long term stability is found to be sufficient to allow a single calibration covering the entire mission period. A descending and an ascending orbit tandem pair of the ESA calibration site on Flevoland, suitable for calibration of ERS SAR processors...

  11. Sorting nexin 17 regulates ApoER2 recycling and reelin signaling.

    Directory of Open Access Journals (Sweden)

    Pablo Sotelo

    Full Text Available ApoER2 is a member of the low density-lipoprotein receptor (LDL-R family. As a receptor for reelin, ApoER2 participates in neuronal migration during development as well as synaptic plasticity and survival in the adult brain. A previous yeast two-hybrid screen showed that ApoER2 is a binding partner of sorting nexin 17 (SNX17 - a cytosolic adaptor protein that regulates the trafficking of several membrane proteins in the endosomal pathway, including LRP1, P-selectin and integrins. However, no further studies have been performed to investigate the role of SNX17 in ApoER2 trafficking and function. In this study, we present evidence based on GST pull-down and inmunoprecipitation assays that the cytoplasmic NPxY endocytosis motif of ApoER2 interacts with the FERM domain of SNX17. SNX17 stimulates ApoER2 recycling in different cell lines including neurons without affecting its endocytic rate and also facilitates the transport of ApoER2 from the early endosomes to the recycling endosomes. The reduction of SNX17 was associated with accumulation of an ApoER2 carboxy-terminal fragment (CTF. In addition, in SNX17 knockdown cells, constitutive ApoER2 degradation was not modified, whereas reelin-induced ApoER2 degradation was increased, implying that SNX17 is a regulator of the receptor's half-life. Finally, in SNX17 silenced hippocampal and cortical neurons, we underscored a positive role of this endosomal protein in the development of the dendritic tree and reelin signaling. Overall, these results establish the role of SNX17 in ApoER2 trafficking and function and aid in identifying new links between endocytic trafficking and receptor signaling.

  12. Sorting nexin 17 regulates ApoER2 recycling and reelin signaling.

    Science.gov (United States)

    Sotelo, Pablo; Farfán, Pamela; Benitez, María Luisa; Bu, Guojun; Marzolo, María-Paz

    2014-01-01

    ApoER2 is a member of the low density-lipoprotein receptor (LDL-R) family. As a receptor for reelin, ApoER2 participates in neuronal migration during development as well as synaptic plasticity and survival in the adult brain. A previous yeast two-hybrid screen showed that ApoER2 is a binding partner of sorting nexin 17 (SNX17) - a cytosolic adaptor protein that regulates the trafficking of several membrane proteins in the endosomal pathway, including LRP1, P-selectin and integrins. However, no further studies have been performed to investigate the role of SNX17 in ApoER2 trafficking and function. In this study, we present evidence based on GST pull-down and inmunoprecipitation assays that the cytoplasmic NPxY endocytosis motif of ApoER2 interacts with the FERM domain of SNX17. SNX17 stimulates ApoER2 recycling in different cell lines including neurons without affecting its endocytic rate and also facilitates the transport of ApoER2 from the early endosomes to the recycling endosomes. The reduction of SNX17 was associated with accumulation of an ApoER2 carboxy-terminal fragment (CTF). In addition, in SNX17 knockdown cells, constitutive ApoER2 degradation was not modified, whereas reelin-induced ApoER2 degradation was increased, implying that SNX17 is a regulator of the receptor's half-life. Finally, in SNX17 silenced hippocampal and cortical neurons, we underscored a positive role of this endosomal protein in the development of the dendritic tree and reelin signaling. Overall, these results establish the role of SNX17 in ApoER2 trafficking and function and aid in identifying new links between endocytic trafficking and receptor signaling.

  13. Using PR Tools to Boost Recruitment.

    Science.gov (United States)

    Rabbino, Irma L.

    1979-01-01

    Public relations and admissions are shown to be related. It is not necessary to use exotic PR tools to recruit students. Some suggestions include: the magic of marketing; national, local and hometown media; publications; filmstrips or cassettes; fairs and festivals; public service; and logo buttons, decals, etc. (MLW)

  14. Minimising Immunohistochemical False Negative ER Classification Using a Complementary 23 Gene Expression Signature of ER Status

    DEFF Research Database (Denmark)

    Li, Qiyuan; Eklund, Aron Charles; Birkbak, Nicolai Juul;

    2010-01-01

    subtypes as compared to IHC-based determination has not been systematically evaluated. Here we attempt to reduce the frequency of false negative ER status classification using two gene expression approaches and compare these methods to IHC based ER status in terms of predictive and prognostic concordance......BACKGROUND: Expression of the oestrogen receptor (ER) in breast cancer predicts benefit from endocrine therapy. Minimising the frequency of false negative ER status classification is essential to identify all patients with ER positive breast cancers who should be offered endocrine therapies...... in order to improve clinical outcome. In routine oncological practice ER status is determined by semi-quantitative methods such as immunohistochemistry (IHC) or other immunoassays in which the ER expression level is compared to an empirical threshold. The clinical relevance of gene expression-based ER...

  15. Hva er det med Irma?

    Directory of Open Access Journals (Sweden)

    Anne Beate Reinertsen

    2016-10-01

    Full Text Available Abstract: This article is about formative quality assessment in a posthuman or newmaterial perspective; embodied knowledges.  Theory and method are written together in immanence to envision complexity.  The aim and scope of the article is to follow the flow of events Irma produces opening up for affirmative poetical critique praxis. Quality is forwarded as an intensity and force in a moment only.  The moment is therefore the only structure of the text, as moving quality. The intention and inner logic of the text is therefore designed to work against fixed definitions and conceptualizations of what quality and quality assessment is.  This way I hope to show what posthuman and newmaterial approaches can contribute with to build cultures of innovation in which quality is assessed and produces again and again. They put differences to work and open up for creating moments of educational justice. Sammendrag: Artikkelen handler om kvalitetsvurdering i et nymaterielt perspektiv: Kroppslig kunnskap og viten. Teori og metode skrives sammen i immanent samtidighet for å gi et bilde på kompleksitet. Både hensikt og mål med artikkelen er å følge den flyten som Irma som hendelse eller event produserer, for å åpne opp potensialitet for en bekreftende eller affirmativ poetiserende kritikkpraksis og en ny forståelse av- og vurdering for kvalitet. Kvalitet skrives fram som en hendelse, intensitet eller kraft i et øyeblikk. Øyeblikket er derfor tekstens eneste og bærende struktur, som kvalitet i bevegelse. Tekstens indre logikk har slik til hensikt å motvirke forsøk på å skape definerte, faste eller bestemte oppfatninger av hva kvalitet er og hvordan kvalitet kan vurderes. På denne måten håper jeg å vise hva nymaterielle perspektiver kan gjøre for å bygge kulturer for innovasjon hvor kvalitet vurderes og produseres igjen og igjen. De setter forskjellighet i bevegelse og åpner opp for å skape rettferdige utdanningsøyeblikk.

  16. Activation of PERK signaling attenuates Abeta-mediated ER stress.

    Directory of Open Access Journals (Sweden)

    Do Yeon Lee

    Full Text Available Alzheimer's disease (AD is characterized by the deposition of aggregated beta-amyloid (Abeta, which triggers a cellular stress response called the unfolded protein response (UPR. The UPR signaling pathway is a cellular defense system for dealing with the accumulation of misfolded proteins but switches to apoptosis when endoplasmic reticulum (ER stress is prolonged. ER stress is involved in neurodegenerative diseases including AD, but the molecular mechanisms of ER stress-mediated Abeta neurotoxicity still remain unknown. Here, we show that treatment of Abeta triggers the UPR in the SK-N-SH human neuroblastoma cells. Abeta mediated UPR pathway accompanies the activation of protective pathways such as Grp78/Bip and PERK-eIF2alpha pathway, as well as the apoptotic pathways of the UPR such as CHOP and caspase-4. Knockdown of PERK enhances Abeta neurotoxicity through reducing the activation of eIF2alpha and Grp8/Bip in neurons. Salubrinal, an activator of the eIF2alpha pathway, significantly increased the Grp78/Bip ER chaperone resulted in attenuating caspase-4 dependent apoptosis in Abeta treated neurons. These results indicate that PERK-eIF2alpha pathway is a potential target for therapeutic applications in neurodegenerative diseases including AD.

  17. Pilot James Barrilleaux with ER-2 aircraft on ramp

    Science.gov (United States)

    1998-01-01

    James Barrilleaux is the assistant chief pilot for ER-2s in the Flight Crew Branch of NASA's Dryden Flight Research Center, Edwards, California. The ER-2s--civilian variants of the military U-2S reconnaissance aircraft--are part of NASA's Airborne Science program. The ER-2s can carry airborne scientific payloads of up to 2,600 pounds to altitudes of about 70,000 feet to investigate such matters as earth resources, celestial phenomena, atmospheric chemistry and dynamics, and oceanic processes. Barrilleaux has held his current position since February 1998. Barrilleaux joined NASA in 1986 as a U-2/ER-2 pilot with NASA's Airborne Science program at Ames Research Center, Moffett Field, California. He flew both the U-2C (until 1989) and the ER-2 on a wide variety of missions both domestic and international. Barrilleaux flew high-altitude operations over Antarctica in which scientific instruments aboard the ER-2 defined the cause of ozone depletion over the continent, known as the ozone hole. He has also flown the ER-2 over the North Pole. Barrilleaux served for 20 years in the U.S. Air Force before he joined NASA. He completed pilot training at Reese Air Force Base, Lubbock, Texas, in 1966. He flew 120 combat missions as a F-4 fighter pilot over Laos and North Vietnam in 1970 and 1971. He joined the U-2 program in 1974, becoming the commander of an overseas U-2 operation in 1982. In 1983, he became commander of the squadron responsible for training all U-2 pilots and SR-71 crews located at Beale Air Force Base, Marysville, California. He retired from the Air Force as a lieutenant colonel in 1986. On active duty, he flew the U-2, F-4 Phantom, the T-38, T-37, and the T-33. His decorations included two Distinguished Flying Crosses, 12 Air Medals, two Meritorious Service Medals, and other Air Force and South Vietnamese awards. Barrilleaux earned a bachelor of science degree in chemical engineering from Texas A&M University, College Station, in 1964 and a master of science

  18. Er-doped sesquioxides for 1.5-micron lasers - spectroscopic comparisons

    Science.gov (United States)

    Merkle, Larry D.; Ter-Gabrielyan, Nikolay

    2013-05-01

    Due to the favorable thermal properties of sesquioxides as hosts for rare earth laser ions, we have recently studied the spectroscopy of Er:Lu2O3 in the 1400-1700 nm wavelength range, and here report its comparison with our earlier results on Er:Y2O3 and Er:Sc2O3. These studies include absorption and fluorescence spectra, fluorescence lifetimes, and inference of absorption and stimulated emission cross sections, all as a function of temperature. At room temperature, optical absorption limits practical laser operation to wavelengths longer than about 1620 nm. In that spectral range, the strongest stimulated emission peak is that at 1665 nm in Er:Sc2O3, with an effective cross section considerably larger than those of Er:Y2O3 and Er:Lu2O3. At 77K, the absorption is weak enough for efficient laser operation at considerably shorter wavelengths, where there are peaks with much larger stimulated emission cross sections. The three hosts all have peaks near 1575-1580 nm with comparably strong cross sections. As we have reported earlier, it is possible to lase even shorter wavelengths efficiently at this temperature, in particular the line at 1558 nm in Er:Sc2O3. Our new spectroscopic studies of Er:Lu2O3 indicate that its corresponding peak, like that of Er:Sc2O3, has a less favorable ratio of stimulated emission to absorption cross sections. Reasons for the differences will be discussed. We conclude that for most operating scenarios, Er:Sc2O3 is the most promising of the Er-doped sesquioxides studied for laser operation around 1.5-1.6 microns.

  19. Er der en underviser til stede?

    DEFF Research Database (Denmark)

    Christiansen, René Boyer; Nortvig, Anne-Mette; Rosenlund, Lea Tilde

    2015-01-01

    I de senere år er MOOC (Massive Open Online Courses) blevet en faktor på uddannelsesområdet. MOOC-forskning er et forholdsvist nyt felt, men har inden for de seneste 2-3 år udviklet sig med hastige skridt (Liyanagunawardena et al. 2013, Bayne & Ross 2014). En stor del af denne forskning har haft...

  20. Et kors er ikke bare et kors

    DEFF Research Database (Denmark)

    Bach-Nielsen, Carsten

    2015-01-01

    Om et kors, der er rejst uden for den danske kirke i Bruxelles; formodentlig en afledning af det såkaldte Brabanterkors.......Om et kors, der er rejst uden for den danske kirke i Bruxelles; formodentlig en afledning af det såkaldte Brabanterkors....

  1. Multikulturalisme er en ny slags Apartheid

    DEFF Research Database (Denmark)

    Dyrberg, Torben Bech

    2016-01-01

    I en ny antologi retter forfatterne et kritisk lys mod forsvarerne af multikulturalisme. Og det er der god grund til, mener en af bogens redaktører. For den store gruppe, der hylder multikulturen, glemmer i al dens godhed, at de samtidig er med til at undergrave demokratiet og styrke uheldige mag...

  2. Multikulturalisme er en ny slags Apartheid

    DEFF Research Database (Denmark)

    Dyrberg, Torben Bech

    2016-01-01

    I en ny antologi retter forfatterne et kritisk lys mod forsvarerne af multikulturalisme. Og det er der god grund til, mener en af bogens redaktører. For den store gruppe, der hylder multikulturen, glemmer i al dens godhed, at de samtidig er med til at undergrave demokratiet og styrke uheldige mag...

  3. "Det man siger er man selv..."

    DEFF Research Database (Denmark)

    Næsby, Torben; Nørgaard, Britta; Uddholm, Mats

    forhold, der er hermeneutisk, strukturelt og relationelt bestemt. Praksisviden kan ikke være objektiv i gængs forstand, men det behøver ikke at diskvalificere denne viden. Forståelse er altid knyttet til den sag og bundet til den situation man står overfor og i som professionel og som menneske....

  4. Når det bedste er godt

    DEFF Research Database (Denmark)

    Mogensen, Arne; Abildgaard, Lone

    En portefølje er elevens eget udvalg af repræsentative arbejder, samlet gennem en periode og med henblik på vurdering. Det beskrives, hvordan porteføljer ikke kun er en evalueringsform, men også en læringsstrategi i folkeskolens dansk- og matematikundervisning....

  5. Er Skolen virkelig en Troes–Sag?

    DEFF Research Database (Denmark)

    Oxenvad, Carsten Michael

    2004-01-01

    Om Grundtvigs artikel "Er Troen virkelige en Skole-Sag" og Christen Kolds forståelse heraf, samt hvorledes denne blev implementeret i de frie skoler.......Om Grundtvigs artikel "Er Troen virkelige en Skole-Sag" og Christen Kolds forståelse heraf, samt hvorledes denne blev implementeret i de frie skoler....

  6. Hvorfor er Ernæringsdiagnosen vigtig?

    DEFF Research Database (Denmark)

    Winther, Eva

    2013-01-01

    Nutrition Care Process er en cirkulær firetrinsmodel for individuel eller gruppevis diætbehandling eller kostvejledning. Efter indsamling af oplysninger om klientens spisevaner bliver oplysningerne grupperet og analyseret, og der formuleres en syntese/ernæringsdiagnose. Ernæringsdiagnosen er en...

  7. Zzp'ers in de agrarische sector

    NARCIS (Netherlands)

    Knijff, van der A.

    2009-01-01

    Ook in de agrarische sector doet het verschijnsel zzp (zelfstandigen zonder personeel) zich steeds vaker voor en zou daar mogelijk zelfs een grote vlucht kunnen nemen. In dit artikel wordt uitleg gegeven over wat zzp'er zijn inhoudt en de voor- en andelen die een zzp'er ondervindt

  8. Coronavirus infection, ER stress and Apoptosis

    Directory of Open Access Journals (Sweden)

    TO SING eFUNG

    2014-06-01

    Full Text Available The replication of coronavirus, a family of important animal and human pathogens, is closely associated with the cellular membrane compartments, especially the endoplasmic reticulum (ER. Coronavirus infection of cultured cells was previously shown to cause ER stress and induce the unfolded protein response (UPR, a process that aims to restore the ER homeostasis by global translation shutdown and increasing the ER folding capacity. However under prolonged ER stress, UPR can also induce apoptotic cell death. Accumulating evidence from recent studies has shown that induction of ER stress and UPR may constitute a major aspect of coronavirus-host interaction. Activation of the three branches of UPR modulates a wide variety of signaling pathways, such as mitogen-activated protein (MAP kinases activation, autophagy, apoptosis and innate immune response. ER stress and UPR activation may therefore contribute significantly to the viral replication and pathogenesis during coronavirus infection. In this review, we summarize current knowledge on coronavirus-induced ER stress and UPR activation, with emphasis on their cross-talking to apoptotic signaling.

  9. Streaming video - præsentation af trailere over internettet

    DEFF Research Database (Denmark)

    Jensen, Ole Riis; Forchhammer, Søren

    1998-01-01

    Som et led i Tele Danmark Kabel TV's markedsføring ønsker man at kunne præsentere filmtrailere og andet materiale i form af levende billeder til kunderne via Wold Wide Web (WWW). Dette projekts hovedformål er at undersøge eksisterende metoder og udvikle redskaber til at præsentere en tilsvarende ...... interaktiv tjeneste baseret på realtidsfremvisning af videotrailere, såkaldt streaming video og audio, og hvor brugeren kan få information om en film der tænkes udbudt på en pay-per-view kanal. Der i arbejdets forløb blevet opbygget en demo, der implementerer en sådan tjeneste....

  10. "Kven er det som skriv?" Skriveren i romanen Naustet av Jon Fosse

    Directory of Open Access Journals (Sweden)

    Natascha Reinhoff

    2002-08-01

    Full Text Available Når det gjelder romanen Naustet av Jon Fosse er det ikke tvil om at det blant annet – og kanskje hovedsaklig – er „dette noko / skrifta berettar om“. Det er derfor denne romanen også kan kalles for en metaroman. Tematiseringen av skriveren og skriveprosessen i romanen tar ikke bare mye plass på historienivå: Den gjennomsyrer romanen. Nært forbundet med denne tematikken er et fenomen jeg ville kalle for „dobbeltperspektivet i romanen“, og det er dette jeg vil se litt nærmere på her. Selv om romanen Naustet – i god postmoderne tradisjon – i siste – og kanskje allerede i første – instans unndrar seg en fast og entydig tilskrivning av betydning – og slik bevarer sin magi – skal jeg prøve å nærme meg skriveren og dobbeltperspektivet „eit stykke på veg“. Men først et par ord om begrepet skriver.

  11. Préface

    Directory of Open Access Journals (Sweden)

    Sylvie Duvillard

    2010-09-01

    Full Text Available Le moment est opportun, la question foncière est de retour, légitimée par presque une décennie (2001-2008 d’augmentation continue des prix de l’immobilier. De « sommets » , en articles de presse, la montagne et les Alpes en particulier font l’objet, dans ce domaine, d’une attention toute particulière. Le contexte est ici délicat. Les sociétés alpines sont partagées entre désir de préservation d’une forte identité montagnarde et crainte d’une « déprise » économique (agricole, touristique et/...

  12. Préface

    Directory of Open Access Journals (Sweden)

    Hugues François

    2011-01-01

    Full Text Available Le changement climatique revêt en ce début de millénaire les habits de « mal du siècle » prédisant, à l’horizon 2100, un véritable cataclysme pour les sociétés humaines et leur organisation. Par delà le catastrophisme, les bouleversements induits par l’évolution du climat sur nos pratiques de gestion des territoires sont une réalité. Plus que de céder aux sirènes d’un discours alarmiste, il devient indispensable de se doter d’une meilleure connaissance des mécanismes de ces changements et d’e...

  13. Préface

    Directory of Open Access Journals (Sweden)

    Christian Ménard

    2009-10-01

    Full Text Available La piraterie est un phénomène fort complexe qui remonte à la nuit des temps. Déjà 5 000 ans avant J.-C., des exactions sont mentionnées en mer Egée et Méditerranée. Jules César en sera même l’une des célèbres victimes, mais saura prendre, au moment voulu, sa revanche. Tout au long des siècles, le processus restera récurrent (Atlantique, Antilles…, trouvant son apogée dans le premier quart du XIXe siècle avec l’intervention directe de l’U.S. Navy sous la férule de Thomas Jefferson, Président ...

  14. Présentation

    Directory of Open Access Journals (Sweden)

    Aurore Monod Becquelin

    2010-09-01

    Full Text Available Les recherches présentées dans ce volume sont issues des travaux de chercheurs qui se réunissent régulièrement depuis 2005 sur le thème de l’« Agentivité ». Ce groupe rassemble des ethnologues et des linguistes du Laboratoire d’ethnologie et de sociologie comparative (umr 7186, cnrs/université Paris Ouest Nanterre La Défense, du Laboratoire d’anthropologie sociale (umr 7130, Collège de France/ehess Paris/cnrs, de l’École des hautes études en sciences sociales, de l’Institut des hautes étude...

  15. Présentation

    OpenAIRE

    Anis, Jacques; Kleiber, Georges

    2011-01-01

    Présentation de Jacques Anis Michel Galmiche a toujours manifesté une certaine distance vis-à-vis des rites universitaires. Je ne sais pas s’il aurait apprécié l’idée que dix ans après sa disparition, la revue rende hommage à son cofondateur, qui, dans le trio constitué par Michel Arrivé, Rémy Porquier et lui-même fut chargé de transformer en image ce calembour grapho-phonique – Linguistique Institut Nanterre Paris X – dont est issu ce joli nom qui a provoqué quelques erreurs dans des bibliog...

  16. Mechanistic prospective for human PrPC conversion to PrPSc: Molecular dynamic insights

    Directory of Open Access Journals (Sweden)

    Nooshin Azari

    2013-12-01

    Full Text Available PrPC conversion to PrPSc isoform is the main known cause for prion diseases including Crutzfeldt-Jakob, Gerstmann-Sträussler-Sheinker syndrome and fatal familial insomnia in human. The precise mechanism underling this conversion is yet to be well understood. In the present work, using the coordinate file of PrPC (available on the Protein Data Bank as a starting structure, separate molecular dynamic simulations were carried out at neutral and acidic pH in an explicit water box at 37°C and 1 atmosphere pressure for 10ns second period. Results showed that the acidic pH accelerates PrPC conversion to PrPSc by decreasing the protein gyration radius, flexibility and protein-solvent hydrogen bonds. In acidic conditions, PrPC attains a more folded and less flexible tertiary structure compared to its native structure at neutral pH; otherwise, the decrease of protein-solvent hydrogen bonds at acidic pH will enhance the hydrophobic character of PrPC that may exhibit association as multimeric assemblies. It can also lower water solubility and increase resistance to proteolytic degradations. Data indicated that there was no sensible protein denaturation during this conversion. It is hypothesized that the formation of slightly misfolded conformations with minor structural changes in secondary and/or tertiary structures are enough to menace scrapie formation in PrPC. Our findings show that scrapie formation seems to be a theoretically reversible process.

  17. Présentation

    Directory of Open Access Journals (Sweden)

    Leger Claude-Louis

    2000-05-01

    Full Text Available Ce qui frappe aujourd’hui, c’est une évolution rapide des connaissances sur les quatre vitamines liposolubles qui font l’objet des revues générales présentées dans ce dossier, et plus particulièrement peut-être sur les vitamines A, D et E. On savait ces vitamines indispensables en raison de leur implication dans les réactions cellulaires, pas uniquement métaboliques d’ailleurs, mais on ne pouvait les soupçonner d’intervenir dans des phénomènes complexes touchant aux régulations cellulaires et à l’expression des gènes avant l’explosion des techniques de biologie moléculaire. Ces trois vitamines ont ainsi, entre autres, la capacité de réguler la prolifération et la différenciation cellulaire selon des mécanismes qui peuvent paraître différents aujourd’hui dans certains cas (pour la vitamine E par exemple, ou souvent proches (cas des vitamine A et D. Les quatre vitamines sont capables en revanche d’intervenir dans la mort cellulaire programmée (apoptose. Dans le cas du tissu osseux, ce sont les vitamines A, D et K qui agissent sur l’accrétion calcique. La vitamine E, quant à elle, pourrait prévenir, au moins théoriquement, l’ostéoporose.

  18. Minimising immunohistochemical false negative ER classification using a complementary 23 gene expression signature of ER status.

    Directory of Open Access Journals (Sweden)

    Qiyuan Li

    Full Text Available BACKGROUND: Expression of the oestrogen receptor (ER in breast cancer predicts benefit from endocrine therapy. Minimising the frequency of false negative ER status classification is essential to identify all patients with ER positive breast cancers who should be offered endocrine therapies in order to improve clinical outcome. In routine oncological practice ER status is determined by semi-quantitative methods such as immunohistochemistry (IHC or other immunoassays in which the ER expression level is compared to an empirical threshold. The clinical relevance of gene expression-based ER subtypes as compared to IHC-based determination has not been systematically evaluated. Here we attempt to reduce the frequency of false negative ER status classification using two gene expression approaches and compare these methods to IHC based ER status in terms of predictive and prognostic concordance with clinical outcome. METHODOLOGY/PRINCIPAL FINDINGS: Firstly, ER status was discriminated by fitting the bimodal expression of ESR1 to a mixed Gaussian model. The discriminative power of ESR1 suggested bimodal expression as an efficient way to stratify breast cancer; therefore we identified a set of genes whose expression was both strongly bimodal, mimicking ESR expression status, and highly expressed in breast epithelial cell lines, to derive a 23-gene ER expression signature-based classifier. We assessed our classifiers in seven published breast cancer cohorts by comparing the gene expression-based ER status to IHC-based ER status as a predictor of clinical outcome in both untreated and tamoxifen treated cohorts. In untreated breast cancer cohorts, the 23 gene signature-based ER status provided significantly improved prognostic power compared to IHC-based ER status (P = 0.006. In tamoxifen-treated cohorts, the 23 gene ER expression signature predicted clinical outcome (HR = 2.20, P = 0.00035. These complementary ER signature-based strategies

  19. Er-O clustering and its influence on the lattice sites of Er in Si

    CERN Document Server

    Wahl, U; Araújo, J P; Vantomme, A; Langouche, G

    1999-01-01

    We present emission channeling experiments on the lattice location of Er in CZ Si single crystals with a well-defined O concentration of 6.5-6.6 $\\times 10^{17}$ cm$^{-3}$ and 60 keV-implanted Tm+Er doses ranging from 4.3 $\\times 10^{12}$ cm$^{-2}$ to 3.6 $\\times 10^{13}$ cm$^{-2}$. The experimental results are compared to the predictions of a simulator which models the formation of Er$_{n}$O$_{m}$ clusters on the basis of simple diffusion and capture kinetics. We find that our experimental data compare favorably with a scenario where the formation of Er$_{n}$O$_{m}$ defects with one or more O atoms is responsible for removing the Er atoms from their tetrahedral interstitial (T) sites. This suggests that Er does no longer occupy the T site even in simple (ErO) pairs.

  20. Completion report for Well Cluster ER-20-6

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    The Well Cluster ER-20-6 drilling and completion project was conducted during February, March, and April of 1996 in support of the Nevada Environmental Restoration Project at the Nevada Test Site (NTS), Nye County, Nevada. This project is part of the DOE`s Underground Test Area (UGTA) subproject at the NTS. The primary UGTA tasks include collecting geological, geophysical, and hydrological data from new and existing wells to define groundwater quality as well as pathways and rates of groundwater migration at the NTS. A program of drilling wells near the sites of selected underground nuclear tests (near-field drilling) was implemented as part of the UGTA subproject to obtain site-specific data on the nature and extent of migration of radionuclides produced by an underground nuclear explosion. The ER-20-6 near-field drilling project was originally planned to be very similar to that recently conducted at Well Cluster ER-20-5, which was designed to obtain data on the existing hydrologic regime near the site of an underground nuclear explosion (IT, 1995; IT, 1996a). However, after further consideration of the goals of the near-field drilling program and the characteristics of the BULLION site, the TWG recommended that the ER-20-6 project be redesigned to accommodate a forced-gradient experiment. This proposed experiment is expected to yield more realistic estimates of transport parameters than can be deduced from sampling and testing natural groundwater flow systems.

  1. ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER

    Science.gov (United States)

    Costello, Joseph L.; Hacker, Christian; Schrader, Tina A.; Zeuschner, Dagmar; Findeisen, Peter

    2017-01-01

    Peroxisomes (POs) and the endoplasmic reticulum (ER) cooperate in cellular lipid metabolism and form tight structural associations, which were first observed in ultrastructural studies decades ago. PO–ER associations have been suggested to impact on a diverse number of physiological processes, including lipid metabolism, phospholipid exchange, metabolite transport, signaling, and PO biogenesis. Despite their fundamental importance to cell metabolism, the mechanisms by which regions of the ER become tethered to POs are unknown, in particular in mammalian cells. Here, we identify the PO membrane protein acyl-coenzyme A–binding domain protein 5 (ACBD5) as a binding partner for the resident ER protein vesicle-associated membrane protein-associated protein B (VAPB). We show that ACBD5–VAPB interaction regulates PO–ER associations. Moreover, we demonstrate that loss of PO–ER association perturbs PO membrane expansion and increases PO movement. Our findings reveal the first molecular mechanism for establishing PO–ER associations in mammalian cells and report a new function for ACBD5 in PO–ER tethering. PMID:28108524

  2. Endoplasmic reticulum (ER Chaperones and Oxidoreductases: Critical Regulators of Tumor Cell Survival and Immunorecognition

    Directory of Open Access Journals (Sweden)

    Thomas eSimmen

    2014-10-01

    Full Text Available Endoplasmic reticulum (ER chaperones and oxidoreductases are abundant enzymes that mediate the production of fully folded secretory and transmembrane proteins. Resisting the Golgi and plasma membrane-directed bulk flow, ER chaperones and oxidoreductases enter retrograde trafficking whenever they are pulled outside of the ER. However, solid tumors are characterized by the increased production of reactive oxygen species (ROS, combined with reduced blood flow that leads to low oxygen supply and ER stress. Under these conditions, hypoxia and the unfolded protein response (UPR upregulate ER chaperones and oxidoreductases. When this occurs, ER oxidoreductases and chaperones become important regulators of tumor growth. However, under these conditions, these proteins not only promote the production of proteins, but also alter the properties of the plasma membrane and hence modulate tumor immune recognition. For instance, high levels of calreticulin serve as an eat-me signal on the surface of tumor cells. Conversely, both intracellular and surface BiP/GRP78 promotes tumor growth. Other ER folding assistants able to modulate the properties of tumor tissue include protein disulfide isomerase (PDI, Ero1α and GRP94. Understanding the roles and mechanisms of ER chaperones in regulating tumor cell functions and immunorecognition will lead to important insight for the development of novel cancer therapies.

  3. Rigtige piger går ikke på htx, men piger er glade for at gå der

    DEFF Research Database (Denmark)

    Ulriksen, Lars; Holmegaard, Henriette Tolstrup

    2007-01-01

    Artiklen præsenterer de første resultater fra en landsdækkende spørgeskemaundersøgelse blandt htx-elever. Undersøgelsen viser, at drengenes valg af htx frem for alt er begrundet i en interesse for naturvidenskab, mens pigerne har flere begrundelser, som vægter næsten lige meget. Der er forskelle ...... på htx føler sig godt tilpas på uddannelsen. Samtidig er hver tredje dreng og hver femte pige enig i, at ?rigtige piger interesser sig ikke for teknik & naturvidenskab?....

  4. Er der nu en strukturelt bestemt langsigts-ledighed i SMEC?: Phillips-kurven i SMEC 99 vis-à-vis SMEC 94

    DEFF Research Database (Denmark)

    Harck, Søren H.

    2003-01-01

    -egenskaber i form af en lodret langsigts-Phillips-kurve/udbuds-kurve. Det viser sig, at SMEC 99 lige så lidt som SMEC 94 indeholder en langsigtet trade off mellem ledighed og lønkvote/realløn og et strukturelt bestemt langsigtet ledighedsniveau. Til gengæld indeholder SMEC 99 (ligesom SMEC 94) en langsigtet...... trade off mellem ledighed og inflation i form af en ordinær, stabil 60'er Phillips-kurve. Men 60'er Phillips-kurven i SMEC 99 er væsentligt fladere end i SMEC 94, og strukturelle forhold spiller en reduceret rolle: i SMEC 99 er lønkvoten/reallønnen pr. konstruktion blevet (gjort) helt betydningsløs...... for Phillips-kurvens position, mens kompensationsgraden empirisk set er blevet betydningsløs (på grund af insignifikans)....

  5. Microstructure, electrical and dielectric properties, and aging behavior of ZPCCA varistor ceramics with Er2O3 doping

    Institute of Scientific and Technical Information of China (English)

    NAHM Choonwoo

    2015-01-01

    The microstructure, electrical and dielectric properties, and DC-accelerated aging of the ZPCCA (ZnO-Pr6O11-CoO- Cr2O3-Al2O3) ceramics were investigated with various contents of Er2O3. The ceramic phases consisted of a bulk phase of ZnO grains, and a minor secondary phase of mixture of Pr6O11 and Er2O3. The increase of the content of doped Er2O3 increased the densities of sintered pellet from 5.66 to 5.85 g/cm3, and decreased the average grain size from 9.6 to 6.3μm. With the increase of the content of doped Er2O3, the breakdown field increased from 2390 to 4530 V/cm, and the nonlinear coefficient increased from 28.4 to 39.1. The sample doped with 0.25 mol.% Er2O3 exhibited the strongest electrical stability; variation rates for the breakdown field measured at 1.0 mA/cm2, and for the non-ohmic coefficient were –3.4% and –23.8%, respectively, after application of a stress of 0.95 EB/125°C/24 h.

  6. 抗牛PrP多肽单克隆抗体的制备及其在牛PrP检测中的应用

    Institute of Scientific and Technical Information of China (English)

    赵丽; 侯星生; 计融; 韩春卉; 于修平; 洪涛

    2009-01-01

    为获得广谱抗哺乳类动物PrP单克隆抗体(monoclonal antibody,McAb),用牛朊蛋白(prion protein,PrP)多肽(209~228 aa)与匙孔槭血蓝蛋白(keyhole limpet hemocyanin,KLH)偶联物免疫BalblC小鼠.经细胞融合和克隆后获得针对上述多肽的杂交瘤细胞株.分别用Western blot和免疫组化(immunohistochemistry,IHC)的方法检测这些McAbs与重组人(human,Hu)、牛(bovine,Bo)、仓鼠(hamster,Ha)PrP蛋白、牛脑组织中的正常朊蛋白(cellular PrP,erP)和致病性朊蛋白(scrapie of prion,PrPSc)的反应性.本文为制备高效价抗PrPMcAb提供了一个简单、易行的方法.制备的抗体可用于研究哺乳类PrP生物学特性,检测可传播性海绵样脑病,特别是对牛海绵样脑病的诊断具有重要意义.

  7. Main: PR2GCNT [PLACE

    Lifescience Database Archive (English)

    Full Text Available PR2GCNT S000089 10-May-1998 (last modified) kehi GC element conserved in the 5' ups...N.t.); tobacco; group 2; pr-protein; GC element; chitinase; beta-1,3-glucanase; tobacco (Nicotiana tabacum); TAARAGCCGCC ...

  8. Pseudobegivenheter i nyhetsmediene : Hvilke faktorer påvirker publiseringen av arrangerte PR-nyheter?

    OpenAIRE

    2013-01-01

    I 1961 navngav den amerikanske kulturhistorikeren Daniel J. Boorstin et fenomen han kalte «pseudobegivenheter». Pseudobegivenheter er arrangerte begivenheter som først og fremst er tilrettelagt for mediedekning. Denne masteroppgavens tar for seg hvilke faktorer som påvirker publiseringen av slike arrangerte PR-nyheter i nyhetsmediene. De relevante faktorene ble funnet gjennom grundige undersøkelser av tre forskningsspørsmål med vekt på hvilke nyhetsverdier som har betydning for publiseringen,...

  9. Der er ingen stemmer i kulturpolitik

    DEFF Research Database (Denmark)

    Rasmussen, Casper Hvenegaard

    og forbedret adgang til dannelseskulturen. For det andet har begreber som habitus, kulturel kapital og distinktion været kvalitative forklaringer på de problemer, som demokratiseringen af dannelseskulturen er stødt på. For det tredje sætter Bourdieus sene og mere normative forfatterskab fokus på......Der er flere grunde til at Pierre Bourdieu er bruges flittigt i den kulturpolitiske forskning. For det første er Bourdieus studier af feltbegrebet, og særligt udviklingen af den kunstneriske felt, en hjørnesten i forståelsen af en moderne vestlig kulturpolitik, der bygger på offentlig kunststøtte......, hvordan markedstanken udfordrer kulturfeltets autonomi. Det er særligt kulturfeltets vigende autonomi i en dansk kulturpolitisk kontekst og forandringer i den kulturelle kapital, der er omdrejningspunktet for dette paper. Det er en Bourdieu-inspireret analyse af det offentligt støttede dansk kulturliv...

  10. Ubiquitin Ligase gp78 Targets Unglycosylated Prion Protein PrP for Ubiquitylation and Degradation

    OpenAIRE

    Jia Shao; Vitnary Choe; Haili Cheng; Yien Che Tsai; Weissman, Allan M.; Shiwen Luo; Hai Rao

    2014-01-01

    Prion protein PrP is a central player in several devastating neurodegenerative disorders, including mad cow disease and Creutzfeltd-Jacob disease. Conformational alteration of PrP into an aggregation-prone infectious form PrPSc can trigger pathogenic events. How levels of PrP are regulated is poorly understood. Human PrP is known to be degraded by the proteasome, but the specific proteolytic pathway responsible for PrP destruction remains elusive. Here, we demonstrate that the ubiquitin ligas...

  11. Supervision og de tre k´er

    DEFF Research Database (Denmark)

    Schilling, Benedicte; Jacobsen, Claus Haugaard; Nielsen, Jan

    2010-01-01

    Kontrol, kontrakt og kontekst er supervisionens tre k'er. Men hvad er supervision i det hele taget for en størrelse, der spillerså central en rolle for den psykologfaglige profession?......Kontrol, kontrakt og kontekst er supervisionens tre k'er. Men hvad er supervision i det hele taget for en størrelse, der spillerså central en rolle for den psykologfaglige profession?...

  12. Préface

    Science.gov (United States)

    Aspect, Alain

    2004-11-01

    COLOQ est une conférence regroupant, tous les deux ans, la communauté scientifique et industrielle nationale travaillant dans les domaines des lasers, de l'optique non-linéaire et de l'optique quantique. Elle s'est tenue pour sa huitième édition à Toulouse, du 3 au 5 septembre 2004, sur le campus de I'INSA. Comme il est de tradition tous les quatre ans, COLOQ était couplé avec Horizons de l'optique, avec en particulier une journée commune dont le programme avait été préparé en concertation par les deux comités scientifiques. Depuis sa création, COLOQ a pour but de favoriser les rencontres entre les chercheurs des différents laboratoires nationaux publics ou privés travaillant sur les lasers et l'optique quantique au sens large. C'est un moyen privilégié de resserrer les liens de cette communauté et d'y intégrer les jeunes chercheurs. Ces derniers y trouvent l'occasion de se connaître, de se faire connaître, de découvrir la communauté à laquelle ils appartiennent et d'élargir leurs connaissances des thèmes qui la structurent. La participation de 230 chercheurs et d'une vingtaine d'exposants de matériels spécialisés dans les lasers et l'optoélectronique témoigne de la vitalité de COLOQ et de son audience dans les laboratoires et chez les industriels de l'optique. Le programme de COLOQ 8 comportait d'une vingtaine de conférences générales données par des chercheurs de renom international, et des séances de communications par affiches, occasions privilégiées de rencontres et d'échanges. Les exposés ont porté sur des sujets particulièrement actifs au niveau national et international, avec un accent sur des thèmes importants pour la région toulousaine : contrôle cohérent, optique et nanosciences, optique et astronomie, sans oublier la traditionnelle rubrique phénomènes fondamentaux, éclectique pour ne pas dire hétéroclite, mais si représentative d'une des ambitions de COLOQ qui est d'offrir à ses participants une

  13. Branding er ikke til at komme udenom

    DEFF Research Database (Denmark)

    Hermansen, Judy

    2008-01-01

    Søren Askegaard definerer branding som "et iscenesat og afkodet symbolunivers". Det vil sige, at vi på den ene side har virksomhedens strategiske profilering, hvor den forsøger at skabe sig en særlig differentieret og positioneret profil, som adskiller den fra andre virksomheder. "Og det er denne...... strategiske kommunikation, der gør at branding er et ledelsesbegreb og ikke kun et markedsføringsbegreb. Det er ikke staffage, men værdier, som skal gennemsyre alle organisationens aktiviteter." Udgivelsesdato: maj...

  14. High Performance Calcium Titanate Nanoparticle ER Fluids

    Science.gov (United States)

    Wang, Xuezhao; Shen, Rong; Wen, Weijia; Lu, Kunquan

    A type of calcium titanate (CTO) nanoparticles was synthesized by means of wet chemical method [1] without coating on the particles. The CTO/silicone oil ER fluid exhibits excellent electrorheological properties: high shear stress (~50-100 kPa) under dc electric field, a low current density (less than 2μA/cm2 at 5kV/mm), and long term stability against sedimentation. Although there are not special additives in the ER fluids, it is found from the chemical analysis that a trace of alkyl group, hydroxyl group, carbonyl group and some ions is remained in the particles which may dominate the ER response.

  15. Facilitative plasma membrane transporters function during ER transit.

    Science.gov (United States)

    Takanaga, Hitomi; Frommer, Wolf B

    2010-08-01

    Although biochemical studies suggested a high permeability of the endoplasmic reticulum (ER) membrane for small molecules, proteomics identified few specialized ER transporters. To test functionality of transporters during ER passage, we tested whether glucose transporters (GLUTs, SGLTs) destined for the plasma membrane are active during ER transit. HepG2 cells were characterized by low-affinity ER transport activity, suggesting that ER uptake is protein mediated. The much-reduced capacity of HEK293T cells to take up glucose across the plasma membrane correlated with low ER transport. Ectopic expression of GLUT1, -2, -4, or -9 induced GLUT isoform-specific ER transport activity in HEK293T cells. In contrast, the Na(+)-glucose cotransporter SGLT1 mediated efficient plasma membrane glucose transport but no detectable ER uptake, probably because of lack of a sufficient sodium gradient across the ER membrane. In conclusion, we demonstrate that GLUTs are sufficient for mediating ER glucose transport en route to the plasma membrane. Because of the low volume of the ER, trace amounts of these uniporters contribute to ER solute import during ER transit, while uniporters and cation-coupled transporters carry out export from the ER, together potentially explaining the low selectivity of ER transport. Expression levels and residence time of transporters in the ER, as well as their coupling mechanisms, could be key determinants of ER permeability.

  16. PUMA mediates ER stress-induced apoptosis in portal hypertensive gastropathy.

    Science.gov (United States)

    Tan, S; Wei, X; Song, M; Tao, J; Yang, Y; Khatoon, S; Liu, H; Jiang, J; Wu, B

    2014-03-13

    Mucosal apoptosis has been demonstrated to be an essential pathological feature in portal hypertensive gastropathy (PHG). p53-upregulated modulator of apoptosis (PUMA) was identified as a BH3-only Bcl-2 family protein that has an essential role in apoptosis induced by a variety of stimuli, including endoplasmic reticulum (ER) stress. However, whether PUMA is involved in mucosal apoptosis in PHG remains unclear, and whether PUMA induces PHG by mediating ER stress remains unknown. The aim of the study is to investigate whether PUMA is involved in PHG by mediating ER stress apoptotic signaling. To identify whether PUMA is involved in PHG by mediating ER stress, gastric mucosal injury and apoptosis were studied in both PHG patients and PHG animal models using PUMA knockout (PUMA-KO) and PUMA wild-type (PUMA-WT) mice. The induction of PUMA expression and ER stress signaling were investigated, and the mechanisms of PUMA-mediated apoptosis were analyzed. GES-1 and SGC7901 cell lines were used to further identify whether PUMA-mediated apoptosis was induced by ER stress in vitro. Epithelial apoptosis and PUMA were markedly induced in the gastric mucosa of PHG patients and mouse PHG models. ER stress had a potent role in the induction of PUMA and apoptosis in PHG models, and the apoptosis was obviously attenuated in PUMA-KO mice. Although the targeted deletion of PUMA did not affect ER stress, mitochondrial apoptotic signaling was downregulated in mice. Meanwhile, PUMA knockdown significantly ameliorated ER stress-induced mitochondria-dependent apoptosis in vitro. These results indicate that PUMA mediates ER stress-induced mucosal epithelial apoptosis through the mitochondrial apoptotic pathway in PHG, and that PUMA is a potentially therapeutic target for PHG.

  17. Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production.

    Science.gov (United States)

    Leal, Nuno Santos; Schreiner, Bernadette; Pinho, Catarina Moreira; Filadi, Riccardo; Wiehager, Birgitta; Karlström, Helena; Pizzo, Paola; Ankarcrona, Maria

    2016-09-01

    Mitochondria are physically and biochemically in contact with other organelles including the endoplasmic reticulum (ER). Such contacts are formed between mitochondria-associated ER membranes (MAM), specialized subregions of ER, and the outer mitochondrial membrane (OMM). We have previously shown increased expression of MAM-associated proteins and enhanced ER to mitochondria Ca(2+) transfer from ER to mitochondria in Alzheimer's disease (AD) and amyloid β-peptide (Aβ)-related neuronal models. Here, we report that siRNA knockdown of mitofusin-2 (Mfn2), a protein that is involved in the tethering of ER and mitochondria, leads to increased contact between the two organelles. Cells depleted in Mfn2 showed increased Ca(2+) transfer from ER to mitchondria and longer stretches of ER forming contacts with OMM. Interestingly, increased contact resulted in decreased concentrations of intra- and extracellular Aβ40 and Aβ42 . Analysis of γ-secretase protein expression, maturation and activity revealed that the low Aβ concentrations were a result of impaired γ-secretase complex function. Amyloid-β precursor protein (APP), β-site APP-cleaving enzyme 1 and neprilysin expression as well as neprilysin activity were not affected by Mfn2 siRNA treatment. In summary, our data shows that modulation of ER-mitochondria contact affects γ-secretase activity and Aβ generation. Increased ER-mitochondria contact results in lower γ-secretase activity suggesting a new mechanism by which Aβ generation can be controlled. © 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  18. PR65A phosphorylation regulates PP2A complex signaling.

    Directory of Open Access Journals (Sweden)

    Kumar Kotlo

    Full Text Available Serine-threonine Protein phosphatase 2 A (PP2A, a member of the PPP family of phosphatases, regulates a variety of essential cellular processes, including cell-cycling, DNA replication, transcription, translation, and secondary signaling pathways. In the heart, increased PP2A activity/signaling has been linked to cardiac remodeling, contractile dysfunction and, in failure, arrythmogenicity. The core PP2A complex is a hetero-trimeric holoenzyme consisting of a 36 kDa catalytic subunit (PP2Ac; a regulatory scaffold subunit of 65 kDa (PR65A or PP2Aa; and one of at least 18 associated variable regulatory proteins (B subunits classified into 3 families. In the present study, three in vivo sites of phosphorylation in cardiac PR65A are identified (S303, T268, S314. Using HEK cells transfected with recombinant forms of PR65A with phosphomimetic (P-PR65A and non-phosphorylated (N-PR65A amino acid substitutions at these sites, these phosphorylations were shown to inhibit the interaction of PR65A with PP2Ac and PP2A holoenzyme signaling. Forty-seven phospho-proteins were increased in abundance in HEK cells transfected with P-PR65A versus N-PR65A by phospho-protein profiling using 2D-DIGE analysis on phospho-enriched whole cell protein extracts. Among these proteins were elongation factor 1α (EF1A, elongation factor 2, heat shock protein 60 (HSP60, NADPH-dehydrogenase 1 alpha sub complex, annexin A, and PR65A. Compared to controls, failing hearts from the Dahl rat had less phosphorylated PR65A protein abundance and increased PP2A activity. Thus, PR65A phosphorylation is an in vivo mechanism for regulation of the PP2A signaling complex and increased PP2A activity in heart failure.

  19. ICF Program: LDRD-ER Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Glenzer, S H

    2004-02-05

    In the 01-ERD-107 LDRD-ER project, we have performed novel Thomson scattering experiments at the Trident and Omega laser facilities and provided high quality spectral data. These results have led to the development of the first quantitative understanding of laser-plasma interactions for NIF plasmas. For this purpose an green/ultraviolet probe laser, built for Nova in 1998 [1] and successfully used to measure both temperature and plasma wave amplitudes [2], has been deployed on Omega. The Thomson scattering diagnostics has been used twofold: (1) it provided independent measurements of the plasma electron and ion temperature, the plasma flow velocity, or the electron distribution function; (2) it provided measurements of the primary plasma wave and their secondary non-linear decay wave products. These experiments at Omega provide definitive quantitative results on the nonlinear saturation of stimulated Raman scattering for green (2{omega}) beams. In addition, the experiments on the Trident laser have led to a quantitative understanding of the stimulated Brillouin scattering in low-Z plasmas. A nonlinear frequency detuning model has successfully explained all the experimental observable including the SBS reflectivity. This model has been implemented into the laser-plasma interaction code pF3D as a tool to design and optimize NIF target experiments with SBS and SRS losses included. The development of quantitative models for SBS and SRS for various regimes has now been adopted as part of the WBS1 project within the ICF program.

  20. Hydrodynamic parameters for ErPr cryocooler regenerator fillers under steady and periodic flow conditions

    Science.gov (United States)

    Pathak, M. G.; Patel, V. C.; Ghiaasiaan, S. M.; Mulcahey, T. I.; Helvensteijn, B. P.; Kashani, A.; Feller, J. R.

    2013-12-01

    The regenerator, typically a microporous structure that is subject to periodic flow of a cryogenic fluid, is the most critical component of Pulse Tube or Stirling cryocoolers, which are widely used for high-demand defense and aerospace applications. Despite the critical impact of hydrodynamic irreversibilities in the regenerator on the overall cycle efficiency, the impact of the parameters that influence these losses are poorly understood.

  1. Circulating RANKL and RANKL/OPG and breast cancer risk by ER and PR subtype

    DEFF Research Database (Denmark)

    Sarink, Danja; Schock, Helena; Johnson, Theron

    2017-01-01

    Receptor activator of nuclear factor kappa-B (RANK)-RANK ligand (RANKL) signaling promotes mammary tumor development in experimental models. Circulating concentrations of soluble RANKL (sRANKL) may influence breast cancer risk via activation of RANK signaling; this may be modulated by osteoproteg...

  2. Préface

    Science.gov (United States)

    Ouerdane, Youcef; Laporte, Pierre

    2005-06-01

    L'objectif de la série de colloques UVX est de réunir, au rythme d'une fois tous les deux ans, les scientifiques et industriels travaillant dans le domaine du développement des sources de photon de grande énergie (UV, VUV, et X) et de leurs applications. En particulier cette manifestation est l'occasion de faire se rencontrer une communauté très pluridisciplinaire (physique, chimie, biologie, sciences de l'univers) liée à des domaines en forte évolution technologique (lasers et rayonnement synchrotron notamment). Le colloque UVX 2004 s'est tenu au Palais des Congrès de Saint-Étienne (42000) du 7 au 11 juin 2004. La période écoulée depuis l'édition précédente (Oléron 2002) a été particulièrement active dans tous les domaines concernés : grands projets de sources, méthodes de diagnostic au sens large. Une nouvelle fois on constate que le bref et l'ultra-bref ont une place privilégiée, qu'il s'agisse du travail sur les accélérateurs ou sur les lasers qui, bien sûr, dans la course aux temps courts remportent la palme avec la présence de spécialistes du domaine attoseconde. La communauté représentée a la chance d'être en prise directe avec de très grands projets en phase active de réalisation comme le Laser Megajoule (LMJ), la source SOLEIL, et un projet d'ampleur plus modeste mais remarquable dans son domaine : la source LASERIX d'Orsay/Palaiseau. On pourra citer aussi le projet Arc en Ciel qui, lui, est encore au stade de sa définition. - SOLEIL, source de nouvelle génération de rayonnement synchrotron (plateau de Saclay) est dans une phase active de réalisation : achèvement de l'infrastructure en 2005 et injection du 1o faisceau dans l'anneau de stockage prévu également en 2005. Cette source devrait être la meilleure au monde dans le domaine VUV/X mous, tout en restant très polyvalente (brillance, accordabilité, structure temporelle, polarisation) et complémentaire de l'ESRF. Au final on disposera de 21 lignes de lumi

  3. Préface

    Science.gov (United States)

    Schober, Helmut; Fischer, Henry; Leclercq-Hugeux, Françoise

    2003-09-01

    L'École Thématique “Structure et Dynamique des Systèmes Désordonnés” [1] s'inscrit dans le cadre des écoles organisées sous l'impulsion de la Société Française de la Neutronique (SFN). Elle s'est deroulée en mai 2002 sur la Presqu'île de Giens (Var) en première partie des 11émes Journées de la Diffusion Neutronique. L'Édition de ces cours constitue ainsi le cinquième ouvrage introduisant les techniques neutroniques et leurs apports à differentes thématiques [2]. Le désordre est un facteur déterminant pour pratiquement toutes les propriétés des matériaux. Il est inhérent dans les matériaux amorphes ou liquides, mais il détermine également les propriétés mécaniques et électroniques d'autres composés d'importance technologique comme les matériaux métalliques, dont l'aspect “désordonné” est moins évident. Le désordre enfin joue un rôle essentiel dans tout ce que touche à la vie. En fait, il est difficile d'imaginer des systèmes, à part quelques exceptions rares comme l'hélium ou le silicium de haute pureté, où il n'y ait pas de désordre. En dehors de cet aspect pratique, la description scientifique du désordre atomique pose toujours des problèmes fondamentaux faute de concepts pertinents. Une des tâches importantes du scientifique ou de l'ingenieur est de préciser quel genre de désordre existe à une échelle d'espace et de temps donnée. Un materiau peut très bien être homogène à l'échelle atomique et présenter des défauts ou des hétrogéneité visibles à l'œil et inversement. De même, un système désordonné à un instant donné, peut apparaître ordonné si on moyenne dans le temps. Les techniques de diffusion des neutrons sont idéales pour aborder ces questions. Les neutrons sondent directement les noyaux et ont à la fois des longueurs d'ondes proches des distances inter atomiques et des énergies avoisinant celles des excitations élémentaires de la matière condensée. Ils permettent ainsi

  4. Multicolor Photodetector of a Single Er(3+)-Doped CdS Nanoribbon.

    Science.gov (United States)

    Dedong, Hou; Ying-Kai, Liu; Yu, De-Peng

    2015-12-01

    Er(3+)-doped CdS nanoribbons (Er-CdS NRs) are synthesized by thermal evaporation and then characterized by field emission scanning electron microscopy (FE-SEM), high-resolution transmission electron microscopy (HRTEM), photoluminescence (PL), and absorption spectra. The Er-CdS NR photodetector is studied systematically, including spectral response, light intensity response, and photoconductance (G) versus temperature (T). It is found that Er-CdS NR has the ability of detecting multicolor light including blue, red, and near-infrared light with higher responsivity (R λ ) and external quantum efficiency (η). The conductance of Er-CdS NR under dark conditions decreases with increasing temperature in the range of 87-237 K, while its conductance increases with increasing temperature in the range of 237-297 K when T is larger than 237 K. These results indicated that ionized impurities and the intrinsic excitation are responsible for the conductance change of Er-CdS NR in the dark. The superior performance of the Er-CdS NR device offers an avenue to develop highly sensitive multicolor photodetector applications.

  5. Fluorescence of Er3+:AlN Polycrystalline Ceramic

    Science.gov (United States)

    2012-01-01

    filtration , washed with three successive portions of clean methanol, and air dried in a covered glass evaporation dish. [NH4][ErF4] was included to act as...rotation of the slurry during evaporation provided for a homogeneous powder cake . The dry powders were passed through a 60 mesh stainless steel...conventional uniaxial graphite dies and resistively heated graphite heating elements. Approximately 20 g of the formulated powder was loaded directly into a

  6. Préface

    Science.gov (United States)

    Hamieh, Tayssir

    2005-05-01

    Né simultanément à Mulhouse et à Beyrouth en 1996 dans le cadre d'une collaboraiion franco-libanaise sur une initiative personnelle de Monsieur Tayssir HAMIEH. le Colloque Franco-Libanais sur la Science des Matériaux (CSM), qui s'inscrit dans le cadre des relations étroites entre la France et le Liban, est très vite devenu une occasion très importante de rencontre entre scientifiques de haut niveau, non seulement, du contour méditerranéen mais également des pays européens, américains et arabes. La quatrieme édition CSM4 est une véritable réussite grâce à la participation des chercheurs confirmés dans tous les domaines des sciences de matériaux et venant de plusieurs pays tels que la France, I'Algérie, Le Liban, la Syrie, le Maroc, la Tunisie, l'Italie, l'Espagne, le Portugal, le Royaume Uni, les États-Unis, la Russie, l'Allemagne, le Japon et I'Inde ; pour présenter plus de 350 communications orales et par affiche et couvrant presque toutes les disciplines des systèmes des matériaux. Le choix des diffèrents thèmes du colloque sur la science des matériaux a été dicté par l'importance capitale de cette discipline dans notre civilisation moderne. En fait, les matériaux utilisés pour la fabrication artisanale ou industrielle d'objets, de produits et de systèmes ainsi que pour la réalisation de constructions et d'équipements ont de tout temps défini le niveau de notre civilisation technique. La réalisation des objectifs communs de notre monde en plein développement, pour ne pas dire en pleine mutation, est en grande partie tributaire de la mise au point de nouveaux matériaux et de procédés de transformation et d'assemblages nouveaux, présentant des performances et des qualités améliorées. Le colloque a illustré et traduit, de manière remarquables, l'excellente collaboration entre chercheurs libanais et français. Le partenariat est exemplaire par la qualité des laboratoires impliqués et par le niveau scientifique des r

  7. Environmental release summary (ERS) database CY 1997

    Energy Technology Data Exchange (ETDEWEB)

    Gleckler, B.P.

    1998-07-01

    This report discusses the Environmental Release Summary (ERS) database. The current needs of the Effluent and Environmental database is continually modified to fulfill monitoring (EEM) program (managed by Waste Management Federal Services of Hanford, Incorporated, Air and Water Services Organization). Changes are made to accurately calculate current releases, to affect how past releases are calculated. This document serves as a snap-shot of the database and software for the CY-1997 data and releases. This document contains all of the relevant data for calculating radioactive-airborne and liquid effluent. The ERS database is the official repository for the CY-1997 ERS release reports and the settings used to generate those reports. As part of the Tri-Party Agreement, FDH is committed to provide a hard copy of the ERS database for Washington State Department of Ecology, upon request. This document also serves as that hard copy for the last complete calendar year.

  8. Closed Loop Controlled ER-Actuator

    Science.gov (United States)

    Wolff, C.

    The results of the investigation regarding the suitability of ERF when applied in hydraulics have shown so far that constructing electrorheological flow resistors for the control of pressure and volume flow is possible in principle. One of the main advantages when using the ER-technology in hydraulic systems can be seen in the high reaction rate of the ER-effect. The investigations presented in this article document the dynamic qualities of ER-fluids by means of a practical exploitation for the control of a cylinder actuator. Due to the particular possibilities for design of ER-control resistors a compact cylinder has resulted which differs considerably from traditional cylinder actuators in its construction and dynamic behaviour.

  9. Political PR is dying. Long live business PR! / Ilyn Oleg

    Index Scriptorium Estoniae

    Oleg, Ilyn

    2005-01-01

    Vene suurima suhtekorraldusagentuuri Imageland Public Relations rahvusvaheliste suhete juhi hinnangul on Venemaal peamisteks probleemideks PR professionaalide vähesus, nende kehv haritus oma erialal, samuti vähene teadlikkus suhtekorralduse tähtsusest äris

  10. Political PR is dying. Long live business PR! / Ilyn Oleg

    Index Scriptorium Estoniae

    Oleg, Ilyn

    2005-01-01

    Vene suurima suhtekorraldusagentuuri Imageland Public Relations rahvusvaheliste suhete juhi hinnangul on Venemaal peamisteks probleemideks PR professionaalide vähesus, nende kehv haritus oma erialal, samuti vähene teadlikkus suhtekorralduse tähtsusest äris

  11. Présentation

    Directory of Open Access Journals (Sweden)

    Marie-Hélène Zérah

    2011-11-01

    Full Text Available Ce court texte présente ce numéro spécial sur les villes indiennes et fournit des éléments de contexte pour situer les cinq contributions qui le composent. Avant d'aborder la période actuelle, un survol des politiques urbaines menées dans les décennies suivant l'indépendance souligne le rôle ambigu de la ville dans le modèle indien de développement ainsi que la relative négligence des questions urbaines jusqu'aux années 1980. Dans les années 1990, l'Inde a adopté deux réformes majeures, qui toutes deux ont eu un fort impact sur les villes : la libéralisation économique, d’une part, et la décentralisation politique via un amendement constitutionnel, d’autre part. La libéralisation économique a catalysé un processus de restructuration importante dans les métropoles, soudain perçues comme des atouts précieux pour l'implication de l'Inde dans l'économie mondiale. Cette évolution a soulevé des questions difficiles de gouvernance, notamment parce que les visions de la ville portées par les décideurs politiques prennent mal en compte la complexité des dynamiques sociales et la persistance d’un taux élevé de pauvreté ; les classes moyennes urbaines ont bénéficié plus directement de la croissance économique rapide, ce qui alimente le consumérisme et le marché immobilier. Quant à la décentralisation politique, elle n'a pas produit les résultats attendus, en partie parce que les gouvernements régionaux rechignent à accroître les capacités financières des municipalités. Une analyse critique de la mission nationale pour le renouvellement urbain (JNNURM montre que, même si cette dernière a indéniablement contribué au financement des infrastructures urbaines, elle a été beaucoup moins efficace pour ce qui est de l’amélioration de la gouvernance urbaine. Enfin, les cinq articles de ce numéro sont présentés et l’attention est attirée sur le fait que trois d’entre eux sont rédigés par

  12. Antimicrobial and immunomodulatory activities of PR-39 derived peptides.

    Directory of Open Access Journals (Sweden)

    Edwin J A Veldhuizen

    Full Text Available The porcine cathelicidin PR-39 is a host defence peptide that plays a pivotal role in the innate immune defence of the pig against infections. Besides direct antimicrobial activity, it is involved in immunomodulation, wound healing and several other biological processes. In this study, the antimicrobial- and immunomodulatory activity of PR-39, and N- and C-terminal derivatives of PR-39 were tested. PR-39 exhibited an unexpected broad antimicrobial spectrum including several Gram positive strains such as Bacillus globigii and Enterococcus faecalis. Of organisms tested, only Staphylococcus aureus was insensitive to PR-39. Truncation of PR-39 down to 15 (N-terminal amino acids did not lead to major loss of activity, while peptides corresponding to the C-terminal part of PR-39 were hampered in their antimicrobial activity. However, shorter peptides were all much more sensitive to inhibition by salt. Active peptides induced ATP leakage and loss of membrane potential in Bacillus globigii and Escherichia coli, indicating a lytic mechanism of action for these peptides. Finally, only the mature peptide was able to induce IL-8 production in porcine macrophages, but some shorter peptides also had an effect on TNF-α production showing differential regulation of cytokine induction by PR-39 derived peptides. None of the active peptides showed high cytotoxicity highlighting the potential of these peptides for use as an alternative to antibiotics.

  13. Snip snap snude - dobbelthagerne er ude

    DEFF Research Database (Denmark)

    Larsen, Malene Charlotte; Kofoed, Jette

    2015-01-01

    Det handler om at være grim. Det står i skarp kontrast til det pæne og polerede på Instagram. Det er flygtigt, useriøst og ligegyldigt. Og så forsvinder det heldigvis igen, så man behøver kun at forholde sig til det i de få sekunder, det foregår. Snapchat vokser i popularitet og er nu det...

  14. Trump er godt nyt for verdensfreden

    DEFF Research Database (Denmark)

    Jakobsen, Peter Viggo

    2017-01-01

    Trumps uberegnelighed øger ikke risikoen for krig. Den mindsker den ved at få de allierede til at gøre mere og modstanderne til at forhandle. Det er godt for verdensfreden......Trumps uberegnelighed øger ikke risikoen for krig. Den mindsker den ved at få de allierede til at gøre mere og modstanderne til at forhandle. Det er godt for verdensfreden...

  15. Hvad litteraturen kan, er ofte det rigtige ..

    DEFF Research Database (Denmark)

    Bundsgaard, Jeppe; Kühn, Lisbet

    2010-01-01

    Læsning i dansk handler i første omgang om at blive god til at læse, men på mellemtrinnet er det ved at være tiden til også at bruge skønlitteraturen til det, den er god til, nemlig til at få indsigt i menneskelivets kompleksitet. I dette kapitel anbefales det at gøre noget med litteraturen, fx f...

  16. Topography over South America from ERS altimetry

    Science.gov (United States)

    Brenner, Anita; Frey, Herb; DiMarzio, John; Tsaoussi, Lucia

    1997-01-01

    The results of the surface topography mapping of South America during the ERS-1 geodetic mission are presented. The altimeter waveforms, the range measurement, and the internal and Doppler range corrections were obtained. The atmospheric corrections and solid tides were calculated. Comparisons between Shuttle laser altimetry and ERS-1 altimetry grid showed good agreement. Satellite radar altimetry data can be used to improve the topographic knowledge of regions for which only poor elevation data currently exist.

  17. Arctigenin alleviates ER stress via activating AMPK

    Institute of Scientific and Technical Information of China (English)

    Yuan GU; Xiao-xiao SUN; Ji-ming YE; Li HE; Shou-sheng YAN; Hao-hao ZHANG; Li-hong HU; Jun-ying YUAN; Qiang YU

    2012-01-01

    Aim:To investigate the protective effects of arctigenin (ATG),a phenylpropanoid dibenzylbutyrolactone lignan from Arctium lappa L (Compositae),against ER stress in vitro and the underlying mechanisms.Methods:A cell-based screening assay for ER stress regulators was established.Cell viability was measured using MTT assay.PCR and Western blotting were used to analyze gene and protein expression.Silencing of the CaMKKβ,LKB1,and AMPKα1 genes was achieved by RNA interference (RNAi).An ATP bioluminescent assay kit was employed to measure the intracellular ATP levels.Results:ATG (2.5,5,and 10 μmol/L) inhibited cell death and unfolded protein response (UPR) in a concentration-dependent manner in cells treated with the ER stress inducer brefeldin A (100 nmol/L).ATG (1,5,and 10 μmol/L) significantly attenuated protein synthesis in cells through inhibiting mTOR-p7OS6K signaling and eEF2 activity,which were partially reversed by silencing AMPKα1 with RNAi.ATG (1-50 μmol/L) reduced intracellular ATP level and activated AMPK through inhibiting complex I-mediated respiration.Pretreatment of cells with the AMPK inhibitor compound C (25 μmol/L) rescued the inhibitory effects of ATG on ER stress.Furthermore,ATG (2.5 and 5μmol/L) efficiently activated AMPK and reduced the ER stress and cell death induced by palmitate (2 mmol/L) in INS-1 β cells.Conclusion:ATG is an effective ER stress alleviator,which protects cells against ER stress through activating AMPK,thus attenuating protein translation and reducing ER load.

  18. Håndbold er en praksis!

    DEFF Research Database (Denmark)

    Olsen, Poul Bitsch

    2008-01-01

    Dansk håndbold er en kæmpemæssig succeshistorie. Ser man snævert på den udvikling, elitedelen af sporten har gennemlevet de seneste 15 år, viser stort set alle tænkelige parametre fremgang. De internationale resultater for lands og klubhold er med få udfald blevet stadigt bedre, omsætningen i klu...

  19. Trump er godt nyt for verdensfreden

    DEFF Research Database (Denmark)

    Jakobsen, Peter Viggo

    2017-01-01

    Trumps uberegnelighed øger ikke risikoen for krig. Den mindsker den ved at få de allierede til at gøre mere og modstanderne til at forhandle. Det er godt for verdensfreden......Trumps uberegnelighed øger ikke risikoen for krig. Den mindsker den ved at få de allierede til at gøre mere og modstanderne til at forhandle. Det er godt for verdensfreden...

  20. Arctigenin alleviates ER stress via activating AMPK

    Science.gov (United States)

    Gu, Yuan; Sun, Xiao-xiao; Ye, Ji-ming; He, Li; Yan, Shou-sheng; Zhang, Hao-hao; Hu, Li-hong; Yuan, Jun-ying; Yu, Qiang

    2012-01-01

    Aim: To investigate the protective effects of arctigenin (ATG), a phenylpropanoid dibenzylbutyrolactone lignan from Arctium lappa L (Compositae), against ER stress in vitro and the underlying mechanisms. Methods: A cell-based screening assay for ER stress regulators was established. Cell viability was measured using MTT assay. PCR and Western blotting were used to analyze gene and protein expression. Silencing of the CaMKKβ, LKB1, and AMPKα1 genes was achieved by RNA interference (RNAi). An ATP bioluminescent assay kit was employed to measure the intracellular ATP levels. Results: ATG (2.5, 5 and 10 μmol/L) inhibited cell death and unfolded protein response (UPR) in a concentration-dependent manner in cells treated with the ER stress inducer brefeldin A (100 nmol/L). ATG (1, 5 and 10 μmol/L) significantly attenuated protein synthesis in cells through inhibiting mTOR-p70S6K signaling and eEF2 activity, which were partially reversed by silencing AMPKα1 with RNAi. ATG (1-50 μmol/L) reduced intracellular ATP level and activated AMPK through inhibiting complex I-mediated respiration. Pretreatment of cells with the AMPK inhibitor compound C (25 μmol/L) rescued the inhibitory effects of ATG on ER stress. Furthermore, ATG (2.5 and 5 μmol/L) efficiently activated AMPK and reduced the ER stress and cell death induced by palmitate (2 mmol/L) in INS-1 β cells. Conclusion: ATG is an effective ER stress alleviator, which protects cells against ER stress through activating AMPK, thus attenuating protein translation and reducing ER load. PMID:22705729

  1. Credibility Discourse of PR Agencies

    DEFF Research Database (Denmark)

    Isaksson, Maria; Jørgensen, Poul Erik Flyvholm

    2008-01-01

    This research examines the credibility discourse posted on the corporate websites of 60 British, Danish and Norwegian public relations agencies. The purpose was to determine the nature and patterns of the statements of credibility that PR agencies from different cultures have considered...... instrumental in establishing dependable and likeable images of their ethos. More specifically, the study seeks to establish whether there are distinct cross-cultural preferences in PR credibility discourse. Our assumption was that British and Scandinavian PR agencies assign similar relative importance...

  2. Mutations in the West Nile prM protein affect VLP and virion secretion in vitro.

    Science.gov (United States)

    Calvert, Amanda E; Huang, Claire Y-H; Blair, Carol D; Roehrig, John T

    2012-11-10

    Mutation of the West Nile virus-like particle (WN VLP) prM protein (T20D, K31A, K31V, or K31T) results in undetectable VLP secretion from transformed COS-1 cells. K31 mutants formed intracellular prM-E heterodimers; however these proteins remained in the ER and ER-Golgi intermediary compartments of transfected cells. The T20D mutation affected glycosylation, heterodimer formation, and WN VLP secretion. When infectious viruses bearing the same mutations were used to infect COS-1 cells, K31 mutant viruses exhibited delayed growth and reduced infectivity compared to WT virus. Epitope maps of WN VLP and WNV prM were also different. These results suggest that while mutations in the prM protein can reduce or eliminate secretion of WN VLPs, they have less effect on virus. This difference may be due to the quantity of prM in WN VLPs compared to WNV or to differences in maturation, structure, and symmetry of these particles.

  3. Characterization of the ER-Targeted Low Affinity Ca2+ Probe D4ER

    Directory of Open Access Journals (Sweden)

    Elisa Greotti

    2016-09-01

    Full Text Available Calcium ion (Ca2+ is a ubiquitous intracellular messenger and changes in its concentration impact on nearly every aspect of cell life. Endoplasmic reticulum (ER represents the major intracellular Ca2+ store and the free Ca2+ concentration ([Ca2+] within its lumen ([Ca2+]ER can reach levels higher than 1 mM. Several genetically-encoded ER-targeted Ca2+ sensors have been developed over the last years. However, most of them are non-ratiometric and, thus, their signal is difficult to calibrate in live cells and is affected by shifts in the focal plane and artifactual movements of the sample. On the other hand, existing ratiometric Ca2+ probes are plagued by different drawbacks, such as a double dissociation constant (Kd for Ca2+, low dynamic range, and an affinity for the cation that is too high for the levels of [Ca2+] in the ER lumen. Here, we report the characterization of a recently generated ER-targeted, Förster resonance energy transfer (FRET-based, Cameleon probe, named D4ER, characterized by suitable Ca2+ affinity and dynamic range for monitoring [Ca2+] variations within the ER. As an example, resting [Ca2+]ER have been evaluated in a known paradigm of altered ER Ca2+ homeostasis, i.e., in cells expressing a mutated form of the familial Alzheimer’s Disease-linked protein Presenilin 2 (PS2. The lower Ca2+ affinity of the D4ER probe, compared to that of the previously generated D1ER, allowed the detection of a conspicuous, more clear-cut, reduction in ER Ca2+ content in cells expressing mutated PS2, compared to controls.

  4. Nanostructure of Er3+ doped silicates.

    Science.gov (United States)

    Yao, Nan; Hou, Kirk; Haines, Christopher D; Etessami, Nathan; Ranganathan, Varadh; Halpern, Susan B; Kear, Bernard H; Klein, Lisa C; Sigel, George H

    2005-06-01

    We demonstrate nanostructural evolution resulting in highly increased photoluminescence in silicates doped with Er3+ ions. High-resolution transmission electron microscopy (HRTEM) imaging, nano-energy dispersed X-ray (NEDX) spectroscopy, X-ray diffraction (XRD) and photoluminescence analysis confirm the local composition and structure changes of the Er3+ ions upon thermal annealing. We studied two types of amorphous nanopowder: the first is of the composition SiO2/18Al2O3/2Er2O3 (SAE), synthesized by combustion flame-chemical vapor condensation, and the second is with a composition of SiO2/8Y2O3/2Er2O3 (SYE), synthesized by sol-gel synthesis (composition in mol%). Electron diffraction and HRTEM imaging clearly show the formation of nanocrystallites with an average diameter of approximately 8 nm in SAE samples annealed at 1000 degrees C and SYE samples annealed at 1200 degrees C. The volume fraction of the nanocrystalline phase increased with each heat treatment, eventually leading to complete devitrification at 1400 degrees C. Further XRD and NEDX analysis indicates that the nanocrystalline phase has the pyrochlore structure with the formula Er(x)Al(2-x)Si2O7 or Er(x)Y(2-x)Si2O7 and a surrounding silica matrix.

  5. Single point mutation in tick-borne encephalitis virus prM protein induces a reduction of virus particle secretion.

    Science.gov (United States)

    Yoshii, Kentarou; Konno, Akihiro; Goto, Akiko; Nio, Junko; Obara, Mayumi; Ueki, Tomotaka; Hayasaka, Daisuke; Mizutani, Tetsuya; Kariwa, Hiroaki; Takashima, Ikuo

    2004-10-01

    Flaviviruses are assembled to bud into the lumen of the endoplasmic reticulum (ER) and are secreted through the vesicle transport pathway. Virus envelope proteins play important roles in this process. In this study, the effect of mutations in the envelope proteins of tick-borne encephalitis (TBE) virus on secretion of virus-like particles (VLPs), using a recombinant plasmid expression system was analysed. It was found that a single point mutation at position 63 in prM induces a reduction in secretion of VLPs. The mutation in prM did not affect the folding of the envelope proteins, and chaperone-like activity of prM was maintained. As observed by immunofluorescence microscopy, viral envelope proteins with the mutation in prM were scarce in the Golgi complex, and accumulated in the ER. Electron microscopic analysis of cells expressing the mutated prM revealed that many tubular structures were present in the lumen. The insertion of the prM mutation at aa 63 into the viral genome reduced the production of infectious virus particles. This data suggest that prM plays a crucial role in the virus budding process.

  6. Présentation

    Directory of Open Access Journals (Sweden)

    Gregor Perko

    2011-12-01

    Full Text Available Au cours des dernières décennies où l’on assiste à une refondation de la morphologie, la discipline s’intéresse de plus en plus à des phénomènes « périphériques », « marginaux », « irréguliers » ou « extragrammaticaux », à des phénomènes n’appartenant pas aux « régions nodales » de la morphologie. Le présent numéro de Linguistica, premier numéro thématique de notre revue, réunit des études qui s’intéres- sent aux frontières internes et externes de la morphologie. La diversité et la richesse des thèmes abordés et des approches proposées témoignent d’un intérêt croissant que les linguistes, non pas uniquement les morphologues, portent à cette thématique. Les articles proposés s’articulent autour de cinq axes majeurs. Un premier axe rassemble les articles qui étudient les frontières entre différentes composantes de la morphologie. L’étude de Michel Roché examine les contraintes lexicales et morphophonologiques sur le paradigme des dérivés en –aie. Les résultats de son analyse remettent en question la notion de « règle de construction des lexèmes ». Irena Stramljič Breznik et Ines Voršič se penchent sur les néologismes de sport en slovène et essaient d’évaluer la productivité ou la créativité des procédés morphologiques en jeu. Dans une étude d’inspiration cognitiviste, Alexandra Bagasheva aborde l’hétérogénéité des verbes composés en anglais. En s’appuyant sur les données fournies par les para- digmes verbaux du maltais, Maris Camilleri examine la complexité du phénomène de classes flexionnelles basées sur les radicaux. Trois travaux concernent des procédés typiquement « extragrammaticaux » servant à former le plus souvent des occasionnalismes: Arnaud Léturgie tente de dégager des propriétés prototypiques de l’amalgamation lexicale en français, notamment celles de la création des mots-valises; Silvia Cacchiani analyse, à l

  7. Ice sheet topography from retracked ERS-1 altimetry

    Science.gov (United States)

    Zwally, H. Jay; Brenner, Anita C.; Dimarzio, John; Seiss, Timothy

    1994-01-01

    An objective of the ERS-1 radar altimeter is to measure the surface topography of the polar ice sheets to a precision on the order of a meter. ERS-1 Waveform Altimeter Product (WAP) data was corrected for several processing errors. A range correction from the WAP waveforms, using the multiparameter retracking algorithm to account for range tracking limitations inherent to radar altimetry, was derived. From crossover analysis, the resulting precision is shown to be about 2.1 m in ocean mode and 2.2 m in ice mode. A topography map, produced with 23 days of corrected data, shows details of the western part of west Antarctic ice sheet and part of the Ross ice shelf including ice divides, ice stream boundaries, and ice shelf grounding lines.

  8. Rešeršní studie problematiky zpracování dat v prostředí LabVIEW

    OpenAIRE

    Lejska, Zdeněk

    2013-01-01

    Tato bakalářská práce je zaměřena na rešeršní zpracování problematiky zpracování dat v programu LabVIEW This bachelor thesis is focused on state of art of processing signal data with LabVIEW E

  9. A Role for Macro-ER-Phagy in ER Quality Control.

    Science.gov (United States)

    Lipatova, Zhanna; Segev, Nava

    2015-07-01

    The endoplasmic-reticulum quality-control (ERQC) system shuttles misfolded proteins for degradation by the proteasome through the well-defined ER-associated degradation (ERAD) pathway. In contrast, very little is known about the role of autophagy in ERQC. Macro-autophagy, a collection of pathways that deliver proteins through autophagosomes (APs) for degradation in the lysosome (vacuole in yeast), is mediated by autophagy-specific proteins, Atgs, and regulated by Ypt/Rab GTPases. Until recently, the term ER-phagy was used to describe degradation of ER membrane and proteins in the lysosome under stress: either ER stress induced by drugs or whole-cell stress induced by starvation. These two types of stresses induce micro-ER-phagy, which does not use autophagic organelles and machinery, and non-selective autophagy. Here, we characterize the macro-ER-phagy pathway and uncover its role in ERQC. This pathway delivers 20-50% of certain ER-resident membrane proteins to the vacuole and is further induced to >90% by overexpression of a single integral-membrane protein. Even though such overexpression in cells defective in macro-ER-phagy induces the unfolded-protein response (UPR), UPR is not needed for macro-ER-phagy. We show that macro-ER-phagy is dependent on Atgs and Ypt GTPases and its cargo passes through APs. Moreover, for the first time the role of Atg9, the only integral-membrane core Atg, is uncoupled from that of other core Atgs. Finally, three sequential steps of this pathway are delineated: Atg9-dependent exit from the ER en route to autophagy, Ypt1- and core Atgs-mediated pre-autophagsomal-structure organization, and Ypt51-mediated delivery of APs to the vacuole.

  10. A Role for Macro-ER-Phagy in ER Quality Control.

    Directory of Open Access Journals (Sweden)

    Zhanna Lipatova

    2015-07-01

    Full Text Available The endoplasmic-reticulum quality-control (ERQC system shuttles misfolded proteins for degradation by the proteasome through the well-defined ER-associated degradation (ERAD pathway. In contrast, very little is known about the role of autophagy in ERQC. Macro-autophagy, a collection of pathways that deliver proteins through autophagosomes (APs for degradation in the lysosome (vacuole in yeast, is mediated by autophagy-specific proteins, Atgs, and regulated by Ypt/Rab GTPases. Until recently, the term ER-phagy was used to describe degradation of ER membrane and proteins in the lysosome under stress: either ER stress induced by drugs or whole-cell stress induced by starvation. These two types of stresses induce micro-ER-phagy, which does not use autophagic organelles and machinery, and non-selective autophagy. Here, we characterize the macro-ER-phagy pathway and uncover its role in ERQC. This pathway delivers 20-50% of certain ER-resident membrane proteins to the vacuole and is further induced to >90% by overexpression of a single integral-membrane protein. Even though such overexpression in cells defective in macro-ER-phagy induces the unfolded-protein response (UPR, UPR is not needed for macro-ER-phagy. We show that macro-ER-phagy is dependent on Atgs and Ypt GTPases and its cargo passes through APs. Moreover, for the first time the role of Atg9, the only integral-membrane core Atg, is uncoupled from that of other core Atgs. Finally, three sequential steps of this pathway are delineated: Atg9-dependent exit from the ER en route to autophagy, Ypt1- and core Atgs-mediated pre-autophagsomal-structure organization, and Ypt51-mediated delivery of APs to the vacuole.

  11. PUMA mediates ER stress-induced apoptosis in portal hypertensive gastropathy

    OpenAIRE

    Tan, S; X Wei; Song, M.; Tao, J.; Yang, Y.; Khatoon, S.; Liu, H; Jiang, J.; Wu, B.

    2014-01-01

    Mucosal apoptosis has been demonstrated to be an essential pathological feature in portal hypertensive gastropathy (PHG). p53-upregulated modulator of apoptosis (PUMA) was identified as a BH3-only Bcl-2 family protein that has an essential role in apoptosis induced by a variety of stimuli, including endoplasmic reticulum (ER) stress. However, whether PUMA is involved in mucosal apoptosis in PHG remains unclear, and whether PUMA induces PHG by mediating ER stress remains unknown. The aim of th...

  12. Préface

    Science.gov (United States)

    Paulus, Werner; Meinnel, Jean

    2003-02-01

    de vue européen, si les sources de l'ILL et d'ISIS peuvent encore être considérées comme des leaders au point de vue mondial, il est évidemment souhaitable que la nouvelle source neutronique à spallation (European Spallation Source : ESS) soit rapidement réalisée. Aujourd'hui ce projet est bien avancé, cette source devrait dépasser le flux des sources actuelles par près de deux ordres de grandeur et ainsi de maintenir au meilleur niveau les compétences Européennes. Il est évident qu'une utilisation efficace et intelligente des sources existantes, mais aussi de celles de la nouvelle génération, implique une certaine infrastructure nationale tant au niveau de la conception, de la réalisation que du fonctionnement des différents spectromètres. Ceci implique un très fort engagement des universités dans les différents projets de recherche. Le devoir des universités qui en résulte est donc d'intégrer l'utilisation des “grands instruments" dans leur programme d'enseignement. Dans ce sens, nous souhaitons que ce cours, entièrement rédigé en français, contribue à la fois à aider les chercheurs “non spécialistes” à accéder plus facilement au domaine neutronique, mais aussi à servir de base aux enseignants pour l'organisation et la préparation de leurs cours.Nous tenons à remercier tous les collègues qui ont accepté de rédiger de façon détaillée les cours qu'ils avaient présentés oralement dans la grande salle du VVF de Trégastel, ainsi que toutes les personnes qui ont contribué à la réussite du séjour ou à la réalisation de ce fascicule. Nous gardons un excellent souvenir de l'atmosphère de l'École qui a eu lieu à Trégastel, en plein centre de la côte de granite rose en Bretagne, en mai 2001 et était jumelée avec les Journées de la diffusion neutronique, elles aussi organisées sous l'égide de la SFN.Nous souhaitons que la lecture de cet ouvrage soit utile à un maximum de chercheurs.

  13. Impact of codopant ions on 2.5-3.0 μm emission of Er3+:4I11/2→4I13/2 transition in Yb,Er,Eu:LaYSGG crystal

    Science.gov (United States)

    Wang, Yan; Li, Jianfu; Zhu, Zhaojie; You, Zhenyu; Xu, Jinlong; Tu, Chaoyang

    2015-12-01

    The crystal of 1 at% Yb3+, 10 at% Er3+ and 0.1 at% Eu3+ triply doped La0.3Y2.7Sc2Ga3O12 (abbr. as Yb,Er,Eu:LaYSGG) was grown for the first time by using a Czochralski technique. Its absorption, near-infrared and mid-infrared fluorescence spectra, as well as the fluorescence decay curves of Er:4I13/2 and 4I11/2 levels were measured at room temperature. The spectroscopic properties including the absorption and emission cross-sections as well as the fluorescence lifetimes of the title crystal were revealed and compared with 10 at% Er3+:Y3Sc2Ga3O12 crystal. Spectral analyses show that the sensitization of Yb3+ ion leads to an enhanced 2.5-3.0 μm emission corresponding to Er3+:4I11/2→4I13/2 transition in the grown crystal, meanwhile, the depopulation of Eu3+ ion from Er3+ inhibits the self-termination effect successfully. The energy transfer mechanism was discussed; the energy transfer efficiencies of Yb3+→Er3+ (ET1) and Er3+→Eu3+ (ET2) were estimated to be 94.8% and 93.9%, respectively. The results indicates that Yb,Er,Eu:LaYSGG crystal is a good candidate for LD pumped mid-infrared laser.

  14. PR Crisis Melalui Media Sosial

    Directory of Open Access Journals (Sweden)

    Gladys Carlina

    2017-07-01

    Full Text Available The background of this research is communication, new media, PR and PR Crisis. Fourth of this background has a close relationship, starting from communication, human in everyday life would require communication to receive and convey information, human can not be released from human life. The advancement of the times and the development of technology, causing people to communicate easily and the development of this era caused a new challenge for the PR and PR Crisis of a company, they should be able to maintain a positive image of the company in the minds of people. In this study using descriptive qualitative methodology, it contains many writings and drawings compared to the numbers. The purpose of this research is to know the strategy used by Pizza Hut in dealing with the issue of expired food. Penelitin results, social media is very positive impact on Pizza Hut in the recovery of food issues expired. The strategy used by the Pizza Hut Crisis PR is to utilize social media. Visible from the issue of expired food that disappeared in public and Pizza Hut restaurant until now crowded visited. Latar belakang dari penelitian ini yaitu komunikasi, media baru, PR dan PR Krisis. Keempat dari latar belakang ini mempunyai hubungan yang erat, dimulai dari komunikasi, manusia di dalam kehidupan sehari-hari tentunya memerlukan komunikasi untuk menerima dan menyampaikan informasi, manusia tidak bisa dilepaskan dari kehidupan manusia. Majunya perkembangan zaman dan perkembangan teknologi, menyebabkan manusia melakukan komunikasi dengan mudah dan perkembangan zaman ini menyebabkan adanya tantangan baru bagi para PR dan PR Krisis sebuah perusahaan, mereka harus bisa mempertahankan citra positif perusahaan di benak masyarakat. Dalam penelitian ini menggunakan metodologi kualitatif deksriptif, memuat banyak tulisan dan gambar dibandingkan angka-angka. Tujuan dari penelitian ini untuk mengetahui strategi yang digunakan oleh Pizza Hut dalam menangani isu makanan

  15. Dimerization and protease resistance: new insight into the function of PR-1.

    Science.gov (United States)

    Lu, Shunwen; Faris, Justin D; Sherwood, Robert; Edwards, Michael C

    2013-01-01

    The group 1 pathogenesis-related (PR-1) proteins have long been considered hallmarks of hypersensitive response/defense pathways in plants, but their biochemical functions are still obscure despite resolution of the NMR/X-ray structures of several PR-1-like proteins, including P14a (the prototype PR-1). We report here the characterization of two basic PR-1 proteins (PR-1-1 and PR-1-5) recently identified from hexaploid wheat (Triticum aestivum). Both proteins were expressed in Pichia pastoris as a single major species of ∼15 kDa. Sequence identity of the expressed PR-1 proteins was verified by MALDI-TOF/TOF analysis. Accumulation of the native PR-1-5 protein in pathogen-challenged wheat was confirmed by protein gel blot analysis. Low-temperature SDS-PAGE and yeast two-hybrid assays revealed that PR-1-1 exists primarily as a monomer whereas PR-1-5 forms homodimers. Both PR-1 proteins are resistant to proteases compared to bovine serum albumin, but PR-1-1 shows resistance mainly to subtilisin and protease K (serine proteases) whereas PR-1-5 shows resistance to subtilisin, protease K and papain (a cysteine protease). Site-specific mutations at the five putative active sites in the PR-1 domain all affected dimerization, with the mutations at Glu-72 and Glu-102 (in the PR-1-5 numeration) also diminishing protease resistance. Sequence analysis revealed that the Glu-72 and Glu-102 residues are located in motif-like sequences that are conserved in both PR-1 and the human apoptosis-related caspase proteins. These findings prompt us to examine the function of PR-1 for a role in protease-mediated programmed cell death pathways in plants. Copyright © 2012 Elsevier GmbH. All rights reserved.

  16. Stress Signal Network between Hypoxia and ER Stress in Chronic Kidney Disease

    Science.gov (United States)

    Maekawa, Hiroshi; Inagi, Reiko

    2017-01-01

    Chronic kidney disease (CKD) is characterized by an irreversible decrease in kidney function and induction of various metabolic dysfunctions. Accumulated findings reveal that chronic hypoxic stress and endoplasmic reticulum (ER) stress are involved in a range of pathogenic conditions, including the progression of CKD. Because of the presence of an arteriovenous oxygen shunt, the kidney is thought to be susceptible to hypoxia. Chronic kidney hypoxia is induced by a number of pathogenic conditions, including renal ischemia, reduced peritubular capillary, and tubulointerstitial fibrosis. The ER is an organelle which helps maintain the quality of proteins through the unfolded protein response (UPR) pathway, and ER dysfunction associated with maladaptive UPR activation is named ER stress. ER stress is reported to be related to some of the effects of pathogenesis in kidney, particularly in the podocyte slit diaphragm and tubulointerstitium. Furthermore, chronic hypoxia mediates ER stress in blood vessel endothelial cells and tubulointerstitium via several mechanisms, including oxidative stress, epigenetic alteration, lipid metabolism, and the AKT pathway. In summary, a growing consensus considers that these stresses interact via complicated stress signal networks, which leads to the exacerbation of CKD (Figure 1). This stress signal network might be a target for interventions aimed at ameliorating CKD.

  17. The structural and magnetic properties of Pr1-xErxAl2

    Science.gov (United States)

    Pathak, Arjun K.; Gschneidner, K. A.; Pecharsky, V. K.

    2015-05-01

    We report on the effect of Er addition to PrAl2 on the lattice parameters, magnetic behavior, heat capacity, and magnetocaloric effect by using x-ray diffraction, magnetization, and heat capacity measurements. Unlike Pr0.6Er0.4Al2, other alloys we studied in the pseudobinary (Pr1-xErx)Al2 system do not exhibit a sharp peak in heat capacity with the application of magnetic field. Both the cubic lattice parameter and the Curie temperature decrease with increasing Er concentration. The nuclear specific heat coefficient decreases from 660 mJ K mol-1 for x = 0.05 to a nearly negligible value for x = 0.95. The magnetic entropy and adiabatic temperature change varies from 2 to 4 J mol-1 K-1 and 2.5 to 5 K at ΔH = 20 kOe for x = 0.05 to 0.95, respectively. These values of the magnetocaloric effect are comparable to those of the other rare-earth dialuminides systems.

  18. Microstructure, Magnetism and Magnetic Field Induced-Strain in Er-Doped Co-Ni-Al Polycrystalline Alloy

    Science.gov (United States)

    Ju, Jia; Lou, Shuting; Yan, Chen; Yang, Liu; Li, Tao; Hao, Shuai; Wang, Xingyi; Liu, Huan

    2017-04-01

    A large magnetic field-induced strain (MFIS) was discovered in single-crystal alloys, whereas it is proven difficult for such apparent strain values to be obtained in polycrystalline alloys. In order for an apparent strain discovery to occur, the polycrystalline Co-Ni-Al system was doped by 0-1 at.% of Er and the effects of doping on microstructure, magnetism and MFIS were studied via scanning electron microscopy, x-ray diffraction, transmission electron microscopy and vibrating sample magnetometer in the present work. The microstructure of the alloy was a dual-phase microstructure, including the matrix and the γ phase. Following the Er doping, the γ phase was continuously coarsened, forming a network of precipitates surrounding the grains. Also, a Co-Er-rich intermetallic compound was formed in the Co-rich γ phase when the Er content exceeded 0.1 at.%. The martensitic transformation temperature has a decreasing tendency during the Er being doped from 0 at.% to 1 at.% and the martensitic structure of the sample is of the L10 type, forming twin grains in the (111) twinning plane. On the contrary, the magnetic properties were improved by Er doping, especially saturation magnetization and magneto-crystalline anisotropy constantly increased to 60.45 emu/g and 3.13 × 106 erg/cm3 when the Er content reached 1 at.%, respectively. Also, the strain recovery ratio ( R s) of Co-Ni-Al-Er alloys can be enhanced by thermo-mechanical cycles and Er doping. At 5% of the total strain, the R s value exceeded 83% following thermo-mechanical cycles when the Er doping was 1 at.%. The strain in the applied magnetic field was increased by Er doping and an excess of 140 ppm of MFIS was obtained in the polycrystalline Co-Ni-Al-Er alloys.

  19. TYPES OF WOMAN IN ER TABILDI EPIC / ER TABILDI DESTANINDA KADIN TİPLER

    Directory of Open Access Journals (Sweden)

    Ahmet SAÇKESEN (M.A.H.

    2007-08-01

    Full Text Available Importance and function of Turkish woman will be analyzed during historical process in this article named as “Types of Woman in Er Tabıldı Epic” Types of woman in Er Tabıldı Legend will be explained as ideal wife and mother types ideal lover and assistant types.

  20. Spectroscopic properties of Er doped and Er, Nd codoped fluoride glasses under simulated sunlight illumination

    Science.gov (United States)

    Mizuno, Shintaro; Ito, Hiroshi; Hasegawa, Kazuo; Kawai, Hiroyuki; Nasu, Hiroyuki; Hughes, Mark A.; Suzuki, Takenobu; Ohishi, Yasutake

    2011-10-01

    We investigated the fluorescence characteristics of Er codoped Nd doped ZBLAN glasses proposed for solar pumped fiber laser (SPFL) under simulated sunlight. Er is used as a sensitizer because it absorbs a part of the ultraviolet and visible light where is no absorption of Nd. Under simulated sunlight illumination, Er singly doped fluoride glass displayed four emission bands with peaks at 550, 848, 977 and 1533 nm attributed to the 4S 3/2- 4I 15/2, 4S 3/2- 4I 13/2, 4I 11/2- 4I 15/2 and 4I 13/2- 4I 15/2 electronic transitions of Er, respectively. The quantum efficiency measurement was carried out using an integrating sphere and under the simulated sunlight excitation showed a maximum of 73% for 0.5 mol.% of ErF 3 in ZBLAN glass. In Nd, Er codoped fluoride glass, the 1.05 μm emission of Nd was observed under 380 nm excitation what supposes the energy transfer from Er to Nd in ZBLAN glasses as Nd has no absorption at the wavelength. Er, Nd codoped fluoride glasses are promising as a sensitized laser media for solar pumped fiber lasers.

  1. 20 CFR 216.68 - Disability period for widow(er), surviving divorced spouse, or remarried widow(er).

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Disability period for widow(er), surviving divorced spouse, or remarried widow(er). 216.68 Section 216.68 Employees' Benefits RAILROAD RETIREMENT... Divorced Spouse, and Remarried Widow(er) Annuities § 216.68 Disability period for widow(er),...

  2. Tv nyheder: Journalistiske Idealer er under Pres

    DEFF Research Database (Denmark)

    Thomsen, Line Hassall

    2013-01-01

    om Den Gode Historie mødte jeg på alle fire redaktioner. Ansatte på de fire forskellige redaktioner svarede (næsten ordret) det samme til spørgsmålet om hvad Den Gode Historie er. Ifølge redaktørerne og redaktionssekretærerne er Den Gode Historie den nyhedshistorie der får seeren til ’at snakke......’ hjemme i dagligstuerne. Derfor fortalte journalisterne at de ofte forestillede sig at de fortalte en nyhedshistorie til deres mor eller deres venner for at tænke sig til om det var en nyhed der ville blive talt om hjemme i dagligstuen. Journalisterne selv beskrev den Gode Historie som den nyhed der både...... er objektiv, oplyser seeren, er dybdeborende, forbedrer verden og er kritisk overfor autoriteterne på vegne af befolkningen. At lave den slags historier blev talt om blandt journalisterne som ’God Journalistik’. Mange nævnte disse fjerde statsmagts idealer som den vigtigste årsag til at de...

  3. Completion Report for Well Cluster ER-6-1

    Energy Technology Data Exchange (ETDEWEB)

    Bechtel Nevada

    2004-10-01

    Well Cluster ER-6-1 was constructed for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Division at the Nevada Test Site, Nye County, Nevada. This work was initiated as part of the Groundwater Characterization Project, now known as the Underground Test Area Project. The well cluster is located in southeastern Yucca Flat. Detailed lithologic descriptions with stratigraphic assignments for Well Cluster ER-6-1 are included in this report. These are based on composite drill cuttings collected every 3 meters and conventional core samples taken below 639 meters, supplemented by geophysical log data. Detailed petrographic, chemical, and mineralogical studies of rock samples were conducted on 11 samples to resolve complex interrelationships between several of the Tertiary tuff units. Additionally, paleontological analyses by the U.S. Geological Survey confirmed the stratigraphic assignments below 539 meters within the Paleozoic sedimentary section. All three wells in the Well ER-6-1 cluster were drilled within the Quaternary and Tertiary alluvium section, the Tertiary volcanic section, and into the Paleozoic sedimentary section.

  4. Completion report for Well Cluster ER-20-5

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The Well Cluster ER-20-5 drilling and completion project was conducted for the US Department of Energy, Nevada Operations Office (DOE/NV), in support of the Nevada Environmental Restoration Project at the Nevada Test Site (NTS) in Nye County, Nevada. Its primary tasks include collecting geological, geophysical, hydrological, and water chemistry data from new and existing wells to define groundwater quality in addition to pathways and rates of groundwater migration. A program of drilling wells near the sites of selected underground nuclear tests (near-field drilling) was implemented to obtain site-specific data about the nature and extent of migration of radionuclides that might have been produced by an underground nuclear explosion. Well Cluster ER-20-5 is the first near-field drilling project initiated at the NTS. This document presents construction data and summarizes the scientific data gathered during the drilling and well-installation phases for all three holes drilled at Well Cluster ER-20-5. Some of this information is preliminary and unprocessed, but was released so that drilling, geotechnical, well design, and completion data could be rapidly disseminated. Additional information about water levels, aquifer testing, and groundwater sampling will be reported after any of this work is performed. Any additional geologic and/or geophysical investigations conducted for this project is described in one or more analysis and interpretation reports. The lithologic and stratigraphic logs, however, are provided in final form.

  5. Digitale prøver - et litteraturstudie

    DEFF Research Database (Denmark)

    Møller, Karen Louise; Mikkelsen, Thomas

    2015-01-01

    bl.a. om udfordringer hvad angår prøvesystem, organisation, teknologi, kompetenceudvikling og uddannelseskultur. Vi beskriver i artiklen en række konkrete eksempler på digitale prøver, og vi præsenterer resultater fra undersøgelser af underviseres og studerendes oplevelser med digitale prøveformer....

  6. ESO PR Highlights in 2005

    Science.gov (United States)

    2006-01-01

    2005 was the year of Physics. It was thus also in part the year of astronomy and this is clearly illustrated by the numerous breakthroughs that were achieved, in particular using ESO's telescopes. One of the highlights was without any doubt the confirmation of the first image of an exoplanet , around the star 2M1207 (see ESO PR 12/05). ESO's telescopes also found a Neptune-mass exoplanet around a small star ( PR 30/05) - a discovery that proves crucial in the census of other planetary systems, and imaged a tiny companion in the close vicinity of the star GQ Lupi, a very young object still surrounded by a disc, with an age between 100,000 and 2 million years ( PR 09/05). Moreover, using a new high-contrast adaptive optics camera on the VLT, the NACO Simultaneous Differential Imager, or NACO SDI, astronomers were able for the first time to image a companion 120 times fainter than its star , very near the star AB Doradus A. This companion appears to be almost twice as heavy as theory predicts it to be ( PR 02/05). ESO's telescopes proved very useful in helping to solve a 30-year old puzzle . Astronomers have for the first time observed the visible light from a short gamma-ray burst (GRB). Using the 1.5m Danish telescope at La Silla (Chile), they showed that these short, intense bursts of gamma-ray emission most likely originate from the violent collision of two merging neutron stars ( PR 26/05). Additional evidence came from witnessing another event with the VLT ( PR 32/05). Also in this field, astronomers found the farthest known gamma-ray burst with ESO's VLT, observing an object with a redshift 6.3, i.e. that is seen when the Universe was less than 900 million years old ( PR 22/05). On July 4, NASA's Deep Impact spacecraft plunged onto Comet 9P/Tempel 1 with the aim to create a crater and expose pristine material from beneath the surface. For two days before and six days after, all major ESO telescopes have been observing the comet, in a coordinated fashion and in

  7. PR Bibliography, 2002.

    Science.gov (United States)

    Ramsey, Shirley, Ed.

    2002-01-01

    This annotated bibliography presents an overview of journal articles and books published in 2001 on public relations that can be helpful to teachers and students as well as to practitioners and managers. This bibliography is subdivided into 40 categories including campaigns; consumer relations; community relations; corporate social responsibility;…

  8. Sport er hverken sundt eller social

    DEFF Research Database (Denmark)

    Andersen, Tem Frank

    2013-01-01

    Jeg deler ikke Lasch og Kayser Nielsens konklusioner, selvom jeg er meget enig i, at sport er dirty business. Min analyse peger i den retning, at sporten i sin organiserede form ikke er eller kan fungere som leverandør af nogen ”pakkeløsning”. Men sport kan sagtens bidrage med brudstykker til noget...... meningsfuldt, for det enkelte menneske, eller det enkelte lokalsamfund. Sporten kan ikke længere, hvis den skal fremstå som noget ideal, levere en hel pakke, en fuldstændig myte med tilhørende ritualer. Sport kan imidlertid som projekt fortsat godt levere stof til den meningsskabende fortælling om identitet...

  9. IMG ER: A System for Microbial Genome Annotation Expert Review and Curation

    Energy Technology Data Exchange (ETDEWEB)

    Markowitz, Victor M.; Mavromatis, Konstantinos; Ivanova, Natalia N.; Chen, I-Min A.; Chu, Ken; Kyrpides, Nikos C.

    2009-05-25

    A rapidly increasing number of microbial genomes are sequenced by organizations worldwide and are eventually included into various public genome data resources. The quality of the annotations depends largely on the original dataset providers, with erroneous or incomplete annotations often carried over into the public resources and difficult to correct. We have developed an Expert Review (ER) version of the Integrated Microbial Genomes (IMG) system, with the goal of supporting systematic and efficient revision of microbial genome annotations. IMG ER provides tools for the review and curation of annotations of both new and publicly available microbial genomes within IMG's rich integrated genome framework. New genome datasets are included into IMG ER prior to their public release either with their native annotations or with annotations generated by IMG ER's annotation pipeline. IMG ER tools allow addressing annotation problems detected with IMG's comparative analysis tools, such as genes missed by gene prediction pipelines or genes without an associated function. Over the past year, IMG ER was used for improving the annotations of about 150 microbial genomes.

  10. ARM CLASIC ER2 CRS/EDOP

    Energy Technology Data Exchange (ETDEWEB)

    Gerald Heymsfield

    2010-12-20

    Data was taken with the NASA ER-2 aircraft with the Cloud Radar System and other instruments in conjunction with the DOE ARM CLASIC field campaign. The flights were near the SGP site in north Central Oklahoma and targeted small developing convection. The CRS is a 94 GHz nadir pointing Doppler radar. Also on board the ER-2 was the Cloud Physics Lidar (CPL). Seven science flights were conducted but the weather conditions did not cooperate in that there was neither developing convection, or there was heavy rain.

  11. Vi er blevet gode til at budgettere(!?!)

    DEFF Research Database (Denmark)

    Kreiner, Kristian

    2015-01-01

    På det seneste har rektor haft anledning til at fortælle os, at vi på CBS er blevet gode til at budgettere. Men hvad det vil sige at være god til at budgettere? Og hvad bliver disse nye færdigheder så brugt til?......På det seneste har rektor haft anledning til at fortælle os, at vi på CBS er blevet gode til at budgettere. Men hvad det vil sige at være god til at budgettere? Og hvad bliver disse nye færdigheder så brugt til?...

  12. Compiling ER Specifications into Declarative Programs

    CERN Document Server

    Braßel, Bernd; Muller, Marion

    2007-01-01

    This paper proposes an environment to support high-level database programming in a declarative programming language. In order to ensure safe database updates, all access and update operations related to the database are generated from high-level descriptions in the entity- relationship (ER) model. We propose a representation of ER diagrams in the declarative language Curry so that they can be constructed by various tools and then translated into this representation. Furthermore, we have implemented a compiler from this representation into a Curry program that provides access and update operations based on a high-level API for database programming.

  13. Double Clad Er-doped Fiber Amplifier

    Institute of Scientific and Technical Information of China (English)

    FU Yong-jun; MAO Xiang-qiao; WEI Huai; LI jian

    2007-01-01

    Presented is a theoretical study of double-clad Er-doped fiber power amplifier(EDFA). Two kinds of double clad fibers(DCF) with rectangular and "flower" inner clad shapes are studied, and these fibers have different coupling constants and propagation losses. We calculate the effective pump power absorption ratio along the fiber with different coupling constants from the first cladding to the doped core and with different propagation losses for the power in the inner cladding. Then the gains of the double clad Er-doped fiber amplifiers versus fiber lengths are calculated using the EDFA model based on propagation and rate equations of a homogeneous, two-level medium.

  14. OL er en mirakelkur for verdens storbyer

    DEFF Research Database (Denmark)

    Østergaard, Katrine; Møller Christensen, Søren

    2006-01-01

    Der er kamp om at blive værtsby for de olympiske lege. Legene giver værtsbyen global opmærksomhed, kickstarter byudviklingen og giver efter al sandsynlighed økonomisk overskud. Men ikke alle byer slipper lige godt fra opgaven......Der er kamp om at blive værtsby for de olympiske lege. Legene giver værtsbyen global opmærksomhed, kickstarter byudviklingen og giver efter al sandsynlighed økonomisk overskud. Men ikke alle byer slipper lige godt fra opgaven...

  15. Abnormal vascular function in PR-interval prolongation.

    Science.gov (United States)

    Chan, Yap-Hang; Siu, Chung-Wah; Yiu, Kai-Hang; Li, Sheung-Wai; Lau, Kui-Kai; Lam, Tai-Hing; Lau, Chu-Pak; Tse, Hung-Fat

    2011-10-01

    Underlying mechanisms of PR-interval prolongation leading to increased risk of adverse cardiovascular outcomes, including atrial fibrillation, are unclear. This study aims to investigate the relation between PR interval and changes in vascular function. We hypothesize that there exists an intermediate pathological stage between electrocardiographic PR prolongation and adverse cardiovascular outcomes, which could be reflected by changes in surrogate measurements of vascular function. We recruited 88 healthy subjects (mean age 57.5 ± 9.8 y, 46% male) from a community-based health screening program who had no history of cardiovascular disease or diabetes mellitus. PR interval was determined from a resting 12-lead electrocardiogram. Vascular function was noninvasively assessed by flow-mediated dilation (FMD) using high-resolution ultrasound and brachial-ankle pulse wave velocity (PWV) using a vascular profiling system. Only 3 subjects had a PR-interval length longer than the conventional cutoff of 200 ms. The PR-interval length was associated inversely with FMD (Pearson r = -0.30, P = 0.004) and positively with PWV (r = 0.40, P PR-interval length by each 25 ms was independently associated with reduced FMD by -1 unit (absolute %, B = -0.04 [95% confidence interval: -0.080 to -0.002, P = 0.040)] and increased PWV by +103 cm/second (B = +4.1 [95% confidence interval: 0.6-7.6, P = 0.023]). This study shows that PR-interval length, even in the conventionally normal range, is independently associated with endothelial dysfunction and increased arterial stiffness in healthy subjects free of atherosclerotic disease. This suggests the presence of a systemic, intermediate pathologic stage of the vasculature in PR prolongation before clinically manifest cardiovascular events, and could represent a mediating mechanism. © 2011 Wiley Periodicals, Inc.

  16. Prügi, mis polegi prügi

    Index Scriptorium Estoniae

    2007-01-01

    2007. a. oktoobris oli Tallinna Botaanikaaias avatud jäätmete temaatikale pühendatud näitus, mis valmis koostöös Uuskasutuskeskuse ja Tallinna Loomaaiaga. Avatud oli soome fotograafi Timo Vartiaise ning maastikuarhitekti Henrik Jenseni fotonäitus "Prügimägi, mu arm"

  17. Electrocardiographic PR-interval duration and cardiovascular risk

    DEFF Research Database (Denmark)

    Rasmussen, Peter Vibe; Nielsen, Jonas Bille; Skov, Morten Wagner

    2017-01-01

    BACKGROUND: Because of ambiguous reports in the literature, we aimed to investigate the association between PR interval and the risk of all-cause and cardiovascular death, heart failure, and pacemaker implantation, allowing for a nonlinear relationship. METHODS: We included 293,111 individuals...... into 7 groups based on the population PR interval distribution. Cox models were used, with reference to a PR interval between 152 and 161 ms (40th to identified 34,783 deaths from all causes, 9867 cardiovascular deaths, 9526 cases of incident heart...... failure, and 1805 pacemaker implantations. A short PR interval ( 200 ms; HR, 1.23; 95% CI, 1.14-1.32; P risk of cardiovascular death after...

  18. PrEP implementation research in Africa: what is new?

    Directory of Open Access Journals (Sweden)

    Frances M Cowan

    2016-10-01

    Full Text Available Introduction: Of the two million new HIV infections in adults in 2014, 70% occurred in sub-Saharan Africa. Several African countries have already approved guidelines for pre-exposure prophylaxis (PrEP for individuals at substantial risk of HIV as part of combination HIV prevention but key questions remain about how to identify and deliver PrEP to those at greatest need. Throughout the continent, individuals in sero-discordant relationships, and members of key populations (sex workers, men who have sex with men (MSM, transgender women and injection drug users are likely to benefit from the availability of PrEP. In addition, adolescent girls and young women (AGYW are at substantial risk in some parts of the continent. It has been estimated that at least three million individuals in Africa are likely to be eligible for PrEP according to WHO's criteria. Tens of demonstration projects are planned or underway across the continent among a range of countries, populations and delivery settings. Discussion: In each of the target populations, there are overarching issues related to (i creating demand for PrEP, (ii addressing supply-side issues and (iii providing appropriate and tailored adherence support. Critical for creating demand for PrEP is the normalization of HIV prevention. Community-level interventions which engage opinion leaders as well as empowerment interventions for those at highest risk will be key. Critical to supply of PrEP is that services are accessible for all, including for stigmatized populations. Establishing accessible integrated services provides the opportunity to address other public health priorities including the unmet need for HIV testing, contraception and sexually transmitted infections treatment. National policies need to include minimum standards for training and quality assurance for PrEP implementation and to address supply chain issues. Adherence support needs to recognize that social and structural factors are likely

  19. Low temperature properties of some Er-rich intermetallic compounds

    Energy Technology Data Exchange (ETDEWEB)

    K.A. Gshneidner,jr; A.O. Pecharsky; L.Hale; V.K. Pecharsky

    2004-09-30

    The low temperature volumetric heat capacity ({approx}3.5 to 350 K) and magnetic susceptibility ({approx}4 to 320 K) of Er{sub 3}Rh, Er{sub 3}Ir, Er{sub 3}Pt, Er{sub 2}Al, and Er{sub 2}Sn have been measured. All of the compounds order antiferromagnetically (or ferrimagnetically), and most exhibit more than one magnetic ordering transition. The volumetric heat capacities in general are smaller than those of the prototype magnetic regenerator materials, except for Er{sub 3}Ir in the 12 to 14 K temperature range.

  20. NÅR NOGEN LER, ER DER NOGET PÅ SPIL

    DEFF Research Database (Denmark)

    Volf, Mette

    2012-01-01

    idégenerering. I den del, der omhandler designprocessen set som et socialt fænomen, beskriver jeg praksis som interaktioner, som dels skaber situationelle betydninger, dels afdækker normer, som er internalise-rede, og som således fremstår som sandheder i designprofessionen. Jeg argumenterer her for, at sociale...... hierarkier har en betydning for, hvordan designprocesser forløber, hvem der betragtes som kreativ, og hvem der ikke gør. Endvidere gør jeg rede for, at designerne optræder i forskellige roller i idégenereringsfaser – og at humor her spiller en væsentlig rolle – som gør, at normalverdenens sociale hierarkier......, kognitiv designtænkningsteori for dels at gøre rede for en af de herskende tilgange på området, dels for at kunne positionere mig i forhold hertil og efterfølgende præsentere min tilgang til designprocessen som et socialt fænomen med udgangspunkt i antropologiske og so-ciologiske teorier. Eftersom...

  1. Creating Smart-er Cities: An Overview

    Science.gov (United States)

    Allwinkle, Sam; Cruickshank, Peter

    2011-01-01

    The following offers an overview of what it means for cities to be "smart." It draws the supporting definitions and critical insights into smart cities from a series of papers presented at the 2009 Trans-national Conference on Creating Smart(er) Cities. What the papers all have in common is their desire to overcome the all too often…

  2. Er strafferetten kun et offentligt anliggende?

    DEFF Research Database (Denmark)

    Feldtmann, Birgit

    2007-01-01

    Artikelen sætter fokus på spørgsmålet, på hvilke måder strafferetten er - eller kunne være - et anliggende for borgeren, fremfor alene være et anliggende for det statslige strafferetssystem....

  3. Hvad er hjemkundskabslæreren?

    DEFF Research Database (Denmark)

    Benn, Jette

    2009-01-01

        En appetizer: De praktisk-musiske fag på dagsordenen Temaet for denne artikel er hjemkundskabsfaget, -professionen og dens praktisering belyst gennem et interviewstudie fra 2008 af lærerstuderende og deres lærere. Dette studie relateres til forfatterens tidligere studie af fag og profession i...

  4. Wie Let Er Op De Kleintjes?

    NARCIS (Netherlands)

    Menting, Ankie; Orobio De Castro, Bram

    2014-01-01

    Het onderliggende rapport betreft een verslag van het onderzoek dat door Dr. Ankie Menting en Prof. dr. Bram Orobio de Castro (Universiteit Utrecht), in opdracht van Humanitas, is uitgevoerd naar het project Wie Let Er Op De Kleintjes (WLEODK) van Gezin in Balans (Humanitas). In dit onderzoek, dat u

  5. Hvad er der på tapetet?

    DEFF Research Database (Denmark)

    Buhl, Mie

    2008-01-01

    Den skoleskabte virkelighed konstituerer sig visuelt gennem arkitektur, organisering, læremidler og gennem aktørernes sociale praktikker. At forholde sig til den visuelle kontekst er en forudsætning for at forstå, hvorfor der opstår dikotomier som 'dem' og 'os'. Skolen består af selvfølgeligheder...

  6. Er iPad digital udeskole?

    DEFF Research Database (Denmark)

    Schilhab, Theresa

    2014-01-01

    Hvor ’konkret’ skal en oplevelse være, for at intuitionen om, at det selvoplevede styrker læringen, holder? Er brug af tablets (e.g. iPads) et ligebyrdigt alternativ til den konkrete oplevelse?...

  7. Creating Smart-er Cities: An Overview

    Science.gov (United States)

    Allwinkle, Sam; Cruickshank, Peter

    2011-01-01

    The following offers an overview of what it means for cities to be "smart." It draws the supporting definitions and critical insights into smart cities from a series of papers presented at the 2009 Trans-national Conference on Creating Smart(er) Cities. What the papers all have in common is their desire to overcome the all too often…

  8. ER and vacuoles: never been closer

    Directory of Open Access Journals (Sweden)

    Corrado eViotti

    2014-02-01

    Full Text Available The endoplasmic reticulum (ER represents the gateway for intracellular trafficking of membrane proteins, soluble cargoes and lipids. In all eukaryotes, the best described mechanism of exiting the ER is via COPII-coated vesicles, which transport both membrane proteins and soluble cargo to the cis-Golgi. The vacuole, together with the plasma membrane, is the most distal point of the secretory pathway, and many vacuolar proteins are transported from the ER through intermediate compartments. However, past results and recent findings demonstrate the presence of alternative transport routes from the ER towards the tonoplast, which are independent of Golgi- and post-Golgi trafficking. Moreover, the transport mechanism of the vacuolar proton pumps VHA-a3 and AVP1 challenges the current model of vacuole biogenesis, pointing to the endoplasmic reticulum for being the main membrane source for the biogenesis of the plant lytic compartment. This review gives an overview of the current knowledge on the transport routes towards the vacuole and discusses the possible mechanism of vacuole biogenesis in plants.

  9. En musikvideo er ikke bare en musikvideo

    Directory of Open Access Journals (Sweden)

    Karin Jacobsen

    1987-08-01

    Full Text Available Mange unge er storkonsumenter af levende billeder. Hvad får de ud af de mange billeder? F. eks. af musikvideoerne? Hvordan får man struktureret et undervisningsforløb i denne nye genre? Og hvordan får man relateret musikvideoerne historisk og æstetisk? Det giver Karin Jacobsen sit bud på.

  10. Branding er ikke til at komme udenom

    DEFF Research Database (Denmark)

    Hermansen, Judy

    2008-01-01

    Søren Askegaard definerer branding som "et iscenesat og afkodet symbolunivers". Det vil sige, at vi på den ene side har virksomhedens strategiske profilering, hvor den forsøger at skabe sig en særlig differentieret og positioneret profil, som adskiller den fra andre virksomheder. "Og det er denne...

  11. Hvad er PET og fMRI?

    DEFF Research Database (Denmark)

    B. Paulson, Olaf; Balslev, Daniela; Gerlach, Christian

    2007-01-01

    Hvilken rolle spiller følelserne for vores tankeliv, og hvorfor har vi overhovedet følelser? I kraft af avancerede hjerneskanningsteknikker er den moderne hjernevidenskab blevet i stand til at besvare disse spørgsmål. Gennem artiklerne i denne antologi, skrevet af ledende danske forskere, bliver ...

  12. Er-doped aluminium oxide waveguide amplifiers

    NARCIS (Netherlands)

    Pollnau, M.

    2008-01-01

    Within the EU STREP project "Photonic integrated devices in activated amorphous and crystalline oxides" (PI-OXIDE, http://pi-oxide.el.utwente.nl/), 6 partners are developing integrated optical devices based on erbium-doped layers of amorphous $Al_2O_3$ and crystalline $Y_2O_3)$. In $Al_2O_3$:Er chan

  13. Danske elever er verdensmestre i demonkati

    DEFF Research Database (Denmark)

    Weirsøe, Mathilde

    2010-01-01

    Danske skoleelever plejer at sakke bagud i internationale undersøgelser, men når det kommer til viden om politik og samfund, er danske 8.-klasse-elever helt i front. En åben, demokratisk skolekultur og kritiske elever kan være en del af forklaringen på, hvorfor Danmark klarer sig bedst i en ny in...

  14. Der er nye elever i klassen

    DEFF Research Database (Denmark)

    Weirsøe, Mathilde

    2010-01-01

    Etniske minoritetsbørn bliver udsat for 'naturlig' forskelsbehandling i de danske skoler, hvor der stadig undervises, som om alle elever hedder Jensen og Petersen. Det er på tide, at pædagogikken anerkender den etniske kompleksitet i vores samfund og indretter undervisningen derefter....

  15. Hvad er hjemkundskabslæreren?

    DEFF Research Database (Denmark)

    Benn, Jette

    2009-01-01

        En appetizer: De praktisk-musiske fag på dagsordenen Temaet for denne artikel er hjemkundskabsfaget, -professionen og dens praktisering belyst gennem et interviewstudie fra 2008 af lærerstuderende og deres lærere. Dette studie relateres til forfatterens tidligere studie af fag og profession i...

  16. Er Frank rationel demokrat eller naiv fetichist?

    DEFF Research Database (Denmark)

    Rösing, Lilian Munk

    2014-01-01

    Artiklen er en diskussion af demokrati-begrebet i Rune Lykkebergs Alle har ret. Over for Lykkebregs demokrati-begreb sætter den Rancières og Zizeks forståelse af demokratiet som en åbning for det, den sociale orden ikke kan rumme. Det fører til en kritik af Lykkebergs anvendelse af begreberne om ...

  17. Protesen er også mig

    DEFF Research Database (Denmark)

    Østergaard, Elisabeth Bomholt

    Protesen er også mig. En antropologisk undersøgelse af, hvordan mennesker, der har fået amputeret en del af et ben, oplever at føle sig hele, at benprotesen inkorporeres og at blive reintegreret i samfundet. Af Elisabeth Bomholt Østergaard, fysioterapeut, MSA, dip.pæd. Vejleder: Anne Line Dalsgaard...

  18. Hvad er PET og fMRI?

    DEFF Research Database (Denmark)

    B. Paulson, Olaf; Balslev, Daniela; Gerlach, Christian

    2007-01-01

    Hvilken rolle spiller følelserne for vores tankeliv, og hvorfor har vi overhovedet følelser? I kraft af avancerede hjerneskanningsteknikker er den moderne hjernevidenskab blevet i stand til at besvare disse spørgsmål. Gennem artiklerne i denne antologi, skrevet af ledende danske forskere, bliver ...

  19. Deformation of Rapidly Solidified Ti-2Er.

    Science.gov (United States)

    1986-09-01

    for the Ti-2Er. ACKNOWLEDGEMENTS The authors wish to thank Dr. Michael . Gigliotti and Mr. Lee Perocchi of the General Electric Research Laboratory for...Proc Conf), Vol. 1, Munich, Sept. 10-14, , *,, 1984, 435-441. 4. D.G. Konitzer , B.C. Muddle, H.F. Fraser, and - R. Kirchheim, ibid., 405-410. - % 5

  20. Hvad nu hvis sommerfuglen er ekshibitionist?

    DEFF Research Database (Denmark)

    Rösing, Lilian Munk

    2008-01-01

    Groft sagt vil denne artikel, ved at aflæse hvad hhv. Inger Christensen, Sigmund Freud og Jacques Lacan har at sige om sommerfugle, argumentere for at der er et afgørende skel mellem naturvidenskab og litteraturvidenskab; mellem naturen, dyret, sommerfuglen på den ene side og bevidstheden...

  1. Er danskerne så lykkelige?

    DEFF Research Database (Denmark)

    Lolle, Henrik; Andersen, Jørgen Goul

    2013-01-01

    Forskning i lykke og livstilfredshed, eller subjective well-being, er i de seneste år nærmest eksploderet, og parallelt hermed har der været en stærkt stigende politisk interesse i begrebet, ikke mindst i nationale sammenligninger af lykke- og tilfredshedsniveau. Men kan vi nu også stole på disse...

  2. Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells.

    Science.gov (United States)

    Wang, Jing; Yang, Xin; Zhang, Jingjing

    2016-08-01

    Pancreatic β cell dysfunction, i.e., failure to provide insulin in concentrations sufficient to control blood sugar, is central to the etiology of all types of diabetes. Current evidence implicates mitochondrial oxidative stress and endoplasmic reticulum (ER) stress in pancreatic β cell loss and impaired insulin secretion. Oxidative and ER stress are interconnected so that misfolded proteins induce reactive oxygen species (ROS) production; likewise, oxidative stress disturbs the ER redox state thereby disrupting correct disulfide bond formation and proper protein folding. mTOR signaling regulates many metabolic processes including protein synthesis, cell growth, survival and proliferation. Oxidative stress inhibits mTORC1, which is considered an important suppressor of mitochondrial oxidative stress in β cells, and ultimately, controls cell survival. The interplay between ER stress and mTORC1 is complicated, since the unfolded protein response (UPR) activation can occur upstream or downstream of mTORC1. Persistent activation of mTORC1 initiates protein synthesis and UPR activation, while in the later phase induces ER stress. Chronic activation of ER stress inhibits Akt/mTORC1 pathway, while under particular settings, acute activation of UPR activates Akt-mTOR signaling. Thus, modulating mitochondrial oxidative stress and ER stress via mTOR signaling may be an approach that will effectively suppress obesity- or glucolipotoxicity-induced metabolic disorders such as insulin resistance and type 2 diabetes mellitus (T2DM). In this review, we focus on the regulations between mTOR signaling and mitochondrial oxidative or ER stress in pancreatic β cells.

  3. ZmbZIP60 mRNA is spliced in maize in response to ER stress

    Directory of Open Access Journals (Sweden)

    Li Yanjie

    2012-03-01

    Full Text Available Abstract Background Adverse environmental conditions produce ER stress and elicit the unfolded protein response (UPR in plants. Plants are reported to have two "arms" of the ER stress signaling pathway-one arm involving membrane-bound transcription factors and the other involving a membrane-associated RNA splicing factor, IRE1. IRE1 in yeast to mammals recognizes a conserved twin loop structure in the target RNA. Results A segment of the mRNA encoding ZmbZIP60 in maize can be folded into a twin loop structure, and in response to ER stress this mRNA is spliced, excising a 20b intron. Splicing converts the predicted protein from a membrane-associated transcription factor to one that is targeted to the nucleus. Splicing of ZmbZIP60 can be elicited in maize seedlings by ER stress agents such as dithiothreitol (DTT or tunicamycin (TM or by heat treatment. Younger, rather than older seedlings display a more robust splicing response as do younger parts of leaf, along a developmental gradient in a leaf. The molecular signature of an ER stress response in plants includes the upregulation of Binding Protein (BIP genes. Maize has numerous BIP-like genes, and ER stress was found to upregulate one of these, ZmBIPb. Conclusions The splicing of ZmbZIP60 mRNA is an indicator of ER stress in maize seedlings resulting from adverse environmental conditions such as heat stress. ZmbZIP60 mRNA splicing in maize leads predictively to the formation of active bZIP transcription factor targeted to the nucleus to upregulate stress response genes. Among the genes upregulated by ER stress in maize is one of 22 BIP-like genes, ZmBIPb.

  4. A conserved region in the prM protein is a critical determinant in the assembly of flavivirus particles.

    Science.gov (United States)

    Yoshii, Kentaro; Igarashi, Manabu; Ichii, Osamu; Yokozawa, Kana; Ito, Kimihito; Kariwa, Hiroaki; Takashima, Ikuo

    2012-01-01

    Flaviviruses are assembled to bud into the lumen of the endoplasmic reticulum (ER) and are secreted through the vesicle transport pathway, but the details of the molecular mechanism of virion assembly remain largely unknown. In this study, a highly conserved region in the prM protein was identified among flaviviruses. In the subviral particle (SP) system of tick-borne encephalitis virus (TBEV) and Japanese encephalitis virus, secretion of SPs was impaired by a mutation in the conserved region in the prM protein. Viral proteins were sparse in the Golgi complex and accumulated in the ER. Ultrastructural analysis revealed that long filamentous structures, rather than spherical SPs, were observed in the lumen of the ER as a result of the mutation. The production of infectious virions derived from infectious cDNA of TBEV was also reduced by mutations in the conserved region. Molecular modelling analysis suggested that the conserved region is important for the association of prM-envelope protein heterodimers in the formation of a spike of immature virion. These results are the first demonstration that the conserved region in the prM protein is a molecular determinant for the flavivirus assembly process.

  5. Evaluating Your School PR Investment.

    Science.gov (United States)

    Bagin, Rich

    Educational public relations (PR) is a planned and systematic management function designed to help improve the programs and services of an educational organization. The standards and techniques discussed in this guide are based on the nearly 50 years of experience of the National School Public Relations Association (NSPRA). The guidebook offers…

  6. Spectroscopic properties of $Pr^{3+}$-doped erbiumoxalate crystals

    Indian Academy of Sciences (India)

    R Pragash; N V Unnikrishnan; C Sudarsanakumar

    2011-12-01

    Spectroscopic properties of praseodymium ions-doped erbium oxalate ($Er_2(C_2O_4)_3 \\cdot nH_2O$) crystals have been investigated. The crystals were grown by hydro silica gel method under suitable pH conditions and by single diffusion method. The well-grown crystals are bright and transparent. The dark green colour of these crystals changes with the variation of the concentrations of the dopant ions. The absorption spectra have been measured in the region 200–800 nm at room temperature. Judd–Ofelt intensity parameters for f–f transitions of the $Pr^{3+}$ ions have been determined as 2 = 166.7, 4 = 1.103 and 6 = 2.898. Analyses of the absorption spectra also show a possible energy transfer from the host material to the dopant.

  7. Tau-er of Power

    OpenAIRE

    Kosik, Kenneth S.

    2015-01-01

    Editor’s Note: Tau protein helps nerve cells in the brain maintain their function and structure. When tau turns toxic, replicates, and spreads, neurons misfire and die. If neuroscientists can pinpoint the reasons for toxicity, identify what our author calls “a staggering number of possible modified tau states,” and find a way to block tau’s movement from cell to cell, then progress can be made in fighting any number of neurological disorders linked to this protein, including frontotemporal de...

  8. Synthesis of Er3+ and Er3+ : Yb3+ doped sol–gel derived silica glass and studies on their optical properties

    Indian Academy of Sciences (India)

    Dipankar Mandal; H D Banerjee; M L N Goswami; H N Acharya

    2004-08-01

    Er3+ and Er3+ : Yb3+ doped optical quality, crack and bubble free glasses for possible use in making laser material have been prepared successfully through sol–gel route. The thermal and optical, including UV-visible absorption, FTIR etc characterizations were undertaken on the samples. The absorption characteristics of Er3+ doped samples clearly revealed the absorption due to Er3+ ions. On the other hand Yb3+ : Er3+ doped samples showed enhanced absorption due to ${}^{2}F_{7/2} \\rightarrow {}^{2}F_{5/2}$ transition. The absorption and emission crosssection for ${}^{2}F_{7/2} \\leftrightarrow {}^{2}F_{5/2}$ of Yb3+ were estimated. FTIR absorption spectra have clearly shown the reduction of the absorption peak intensity with heat treatment in the range 3700–2900 cm-1. The 960 cm-1 band also showed progressive decrease in the absorption band peak intensity with heat treatment. The result of the investigations with essential discussions and conclusions have been reported in this paper.

  9. Athletes as PR Spokespeople: the NFL’s “A Crucial Catch” PR Campaign Explored

    OpenAIRE

    Chyna Teresa Trible

    2015-01-01

    The results of the present study were presented at the 2015 International Conference on Communication and Management and examined the National Football League’s (NFL) “A Crucial Catch” breast cancer awareness campaign in the United States. Variables included identification with NFL athletes, exposure to the campaign, NFL fanship, and intention to schedule a breast cancer screening (the action promoted by NFL athletes in this PR campaign). Social media outlets and an e-mail listserv of the Sch...

  10. Análise comportamental de recém-nascidos pré-termos incluídos em um programa de estimulação tátil-cinestésica durante a internação hospitalar Behavioral analysis of preterm neonates included in a tactile and kinesthetic stimulation program during hospitalization

    Directory of Open Access Journals (Sweden)

    Andréia M. Ferreira

    2010-04-01

    Full Text Available OBJETIVO: Avaliar o efeito da estimulação tátil-cinestésica na evolução do padrão comportamental e clínico de recém-nascidos pré-termos (RNPT durante o período de internação hospitalar. MÉTODOS: Trinta e dois RNPT, com peso ao nascimento inferior a 2.500 gramas, clinicamente estáveis e destituídos de asfixia perinatal importante foram divididos em 16 bebês do grupo controle (GC e 16 do experimental (GE. Foram coletados dados da evolução clínica a partir dos registros hospitalares e da avaliação comportamental por meio de filmagens semanais de oito minutos, desde a inclusão do RNPT na amostra até a alta hospitalar. RESULTADOS: Tendência a redução do tempo de internação hospitalar, aumento do ganho de peso diário e predominância de comportamentos auto-organizados (respiração regular, estado de alerta, tônus equilibrado, posturas mistas, movimentação coordenada, movimentos de mão na face, sucção, preensão, apoio para os RNPT do GE. A análise comparativa das idades pós-conceptuais divididas em intervalos (I - 31 a 33 semanas 6/7; II - 34 a 36 semanas 6/7; e III - 37 a 39 semanas 6/7 ressaltou, no aspecto motor, um tônus equilibrado e movimentação voluntária coordenada para os três períodos, maior permanência em posturas mistas (intervalo I ou em flexão (intervalo II e a obtenção de respiração mais regular na faixa etária I do GE. CONCLUSÃO: Destaque da estimulação tátil-cinestésica como método de intervenção durante o período de internação hospitalar, contribuindo para a auto-organização e regulação comportamental de RNPT. Artigo registrado no Australian New Zealand Clinical Trials Registry (ANZCTR sob o número ACTRN12610000133033.OBJECTIVE: To evaluate the effect of tactile and kinesthetic stimulation on behavioral and clinical development in preterm neonates while still in the hospital. METHODS: Thirty-two clinically stable preterm infants weighing <2.500 grams, with no

  11. Hvad er vejledningsfaglighed - og er den værd at kæmpe for?

    DEFF Research Database (Denmark)

    Nielsen, Grethe Fogh

    2014-01-01

    I en tid, hvor vejlederprofessionen er under pres fra flere sider, og hvor man kan se, at det økonomiske system sætter en dagsorden, der reducerer vejledning til noget, der kan klares med en chat eller i en kollektiv sammenhæng i klasseværelset, er det væsentligt at tydeliggøre, hvad vejledningsf......I en tid, hvor vejlederprofessionen er under pres fra flere sider, og hvor man kan se, at det økonomiske system sætter en dagsorden, der reducerer vejledning til noget, der kan klares med en chat eller i en kollektiv sammenhæng i klasseværelset, er det væsentligt at tydeliggøre, hvad...

  12. COMPLETION REPORT FOR WELL CLUSTER ER-5-3

    Energy Technology Data Exchange (ETDEWEB)

    BECHTEL NEVADA

    2005-12-01

    the depth of 282.6 meters, prior to development and hydrologic testing. Detailed lithologic descriptions and stratigraphic assignments are included in the report. These are based on composite drill cuttings collected every 3 meters, and 120 sidewall samples taken at various depths below 91 meters in Wells ER-5-3 and ER-5-3 No.2, supplemented by geophysical log data. The wells penetrated Quaternary/Tertiary alluvium to the depth of 622.4 meters, and an 8.5-meter-thick basalt flow was encountered within the alluvium. Tertiary tuff was penetrated to the depth of approximately 1,425.9 meters, where the top of the lower carbonate aquifer was tagged in Well ER-5-3 No.2.

  13. Nuclear methods in technology of Si:Er structures

    Energy Technology Data Exchange (ETDEWEB)

    Naidenov, V.O. [Ioffe Physico-Technical Inst., St. Petersburg (Russian Federation); Sobolev, N.A. [Ioffe Physico-Technical Inst., St. Petersburg (Russian Federation); Alexandrov, O.B. [Ioffe Physico-Technical Inst., St. Petersburg (Russian Federation); Bresler, M.S. [Ioffe Physico-Technical Inst., St. Petersburg (Russian Federation); Gusev, O.V. [Ioffe Physico-Technical Inst., St. Petersburg (Russian Federation); Gusinskii, G.M. [Ioffe Physico-Technical Inst., St. Petersburg (Russian Federation); Shek, E.I. [Ioffe Physico-Technical Inst., St. Petersburg (Russian Federation); Makaviichuk, M.I. [Institute of Microelectronics, Russian Academy of Sciences, Yaroslavl (Russian Federation); Parshin, E.O. [Institute of Microelectronics, Russian Academy of Sciences, Yaroslavl (Russian Federation)

    1995-05-01

    Formation of optically and electrically active Er-related centers and redistribution of Er atoms in Si:Er structures were investigated at annealings in different atmospheres. It is shown that annealing in chlorine-containing atmosphere leads to an increase of photoluminescence intensity at wavelength of 1.54 {mu}m as compared with annealing in argon or oxygen ambient. Annealing atmosphere also affects the behaviour of Er atoms and electrically active Er-related defects introduced by means of diffusion from film source. Silicon nitride films covering a surface of wafers were used to investigate the effect of annealing atmosphere on Er redistribution. Changes of concentration and penetration depth of Er atoms and electrically active Er-related centers dependent on annealing medium arose due to generation of excess vacancies and/or self-interstitials near surface. (orig.).

  14. ER Consolidated Qtrly Rpt_April-June 2016_October 2016

    Energy Technology Data Exchange (ETDEWEB)

    Cochran, John R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-10-01

    This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective action activities being implemented by Sandia National Laboratories, New Mexico (SNL/NM) for the April, May, and June 2016 quarterly reporting period.

  15. Er{sup 3+} diffusion in LiTaO{sub 3} crystal

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, De-Long, E-mail: dlzhang@tju.edu.cn [Department of Opto-electronics and Information Engineering, School of Precision Instruments and Opto-electronics Engineering, Tianjin University, Tianjin 300072 (China); Key Laboratory of Optoelectronic Information Technology (Ministry of Education), Tianjin University, Tianjin 300072 (China); Department of Electronic Engineering and State Key Laboratory of Millimeter Waves, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong (China); Zhang, Qun; Wong, Wing-Han [Department of Opto-electronics and Information Engineering, School of Precision Instruments and Opto-electronics Engineering, Tianjin University, Tianjin 300072 (China); Key Laboratory of Optoelectronic Information Technology (Ministry of Education), Tianjin University, Tianjin 300072 (China); Department of Electronic Engineering and State Key Laboratory of Millimeter Waves, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong (China); Pun, Edwin Yue-Bun [Department of Electronic Engineering and State Key Laboratory of Millimeter Waves, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong (China)

    2015-12-01

    Graphical abstract: Diffusion characteristics of Er{sup 3+} in LiTaO{sub 3} crystal were studied in a wide temperature range from 1000 to 1500 °C. The study shows that Er{sup 3+} doping has little effect on the LiTaO{sub 3} index. Li{sub 2}O out-diffusion is slight for a lower temperature while is moderate for a high temperature. The diffusion can be described by Fick's law of diffusion with a constant Er{sup 3+} diffusivity. Some characteristic diffusion parameters including diffusion constant, activation energy, solubility constant and heat of solution were obtained. In comparison with the case of LiNbO{sub 3}, Er{sup 3+} diffusion in LiTaO{sub 3} is at least two orders slower and Er{sup 3+} solubility in LiTaO{sub 3} is measurably lower. - Highlights: • Diffusion characteristics of Er{sup 3+} in LiTaO{sub 3} crystal were studied. • Diffusion constant is (1.05 ± 0.2) × 10{sup 10} μm{sup 2}/h and activation energy is 3.9 ± 0.04 eV. • Solubility constant is (9.12 ± 1.3) × 10{sup 24} cm{sup −3} and heat of solution is 1.33 ± 0.02 eV. • Er{sup 3+} diffusion in LiTaO{sub 3} is at least two orders slower than in LiNbO{sub 3}. • Er{sup 3+} solubility in LiTaO{sub 3} is measurably lower than in LiNbO{sub 3}. - Abstract: Some Er{sup 3+}-doped LiTaO{sub 3} plates were prepared by in-diffusion of Er-metal film locally coated onto congruent Z-cut substrate in air at a wide temperature range from 1000 to 1500 °C. After diffusion, Er{sup 3+}-doping effect on LiTaO{sub 3} refractive index and Li{sub 2}O out-diffusion arising from Er{sup 3+} in-diffusion were studied at first. Refractive indices at the doped and undoped surface parts were measured by prism coupling technique and the surface composition was estimated. The results show that Er{sup 3+} dopant has small contribution to the LiTaO{sub 3} index. Li{sub 2}O out-diffusion is slight (Li{sub 2}O content loss <0.3 mol%) for the temperature below 1300 °C while is moderate (Li{sub 2}O content loss

  16. Hvad skal danske hospitaler med ungecaféer?

    DEFF Research Database (Denmark)

    Kvisgaard Knudsen, Kristina; Bregnballe, Vibeke

    at forbedre unges oplevelse af at være indlagt, er der i Danmark etableret ungecaféer. Formål: At undersøge ungecaféers betydning for indlagte unge. Metode: Fire semistrukturerede interviews er foretaget med kronisk eller alvorligt syge unge i alderen 11-19 år. De unge har besøgt Café Nexus på Aarhus...

  17. Er frygten for Kina vores eneste håb?

    DEFF Research Database (Denmark)

    Mehlsen, Camilla

    2011-01-01

    Man siger, at håbet er lysegrønt, men i det 21. århundrede er håbet rødt som riget i midten. Mens optimismen vinder frem i Asien med Kina som bannerfører, er Vesten ramt af frygt, og det forplanter sig negativt til uddannelsessystemet. Er positive følelser hemmeligheden bag, at asiatiske lande st...

  18. Ubiquitin ligase gp78 targets unglycosylated prion protein PrP for ubiquitylation and degradation.

    Science.gov (United States)

    Shao, Jia; Choe, Vitnary; Cheng, Haili; Tsai, Yien Che; Weissman, Allan M; Luo, Shiwen; Rao, Hai

    2014-01-01

    Prion protein PrP is a central player in several devastating neurodegenerative disorders, including mad cow disease and Creutzfeltd-Jacob disease. Conformational alteration of PrP into an aggregation-prone infectious form PrPSc can trigger pathogenic events. How levels of PrP are regulated is poorly understood. Human PrP is known to be degraded by the proteasome, but the specific proteolytic pathway responsible for PrP destruction remains elusive. Here, we demonstrate that the ubiquitin ligase gp78, known for its role in protein quality control, is critical for unglycosylated PrP ubiquitylation and degradation. Furthermore, C-terminal sequences of PrP protein are crucial for its ubiquitylation and degradation. Our study reveals the first ubiquitin ligase specifically involved in prion protein PrP degradation and PrP sequences crucial for its turnover. Our data may lead to a new avenue to control PrP level and pathogenesis.

  19. Fast er foranderlig? Arbejdskontekstens betydning for offentligt ansattes public service-motivation

    DEFF Research Database (Denmark)

    Kjeldsen, Anne Mette; Boye, Stefan; Brænder, Morten

    2016-01-01

    Et omdiskuteret spørgsmål i litteraturen om public service motivation (PSM) er, hvorvidt ansattes motivation til at gøre godt for andre og samfundet er en foranderlig størrelse eller en konstant. På baggrund af fem nyere danske studier af udviklingen i PSM over tid blandt leverandører af offentlige...... servicer og administrative ydelser bidrager denne artikel med en analytisk ramme til forklaring af denne udvikling. Studierne peger på, at PSM er foranderlig i niveau og sammensætning, og at ændringer i motivationen kan knyttes til forhold på i hvert fald tre niveauer: Individuelle forhold (f.eks. alder og...... uddannelse), organisatoriske faktorer (f.eks. ledelsesstil) samt politiske forhold og styringstiltag. En prioritet for fremtidig forskning bør derfor være at kortlægge mere præcist, hvordan forhold på disse tre niveauer kan påvirke PSM, samt hvordan samspillet mellem disse forskellige niveauer bidrager til...

  20. Ascariasis er en zoonose i Danmark- sekundærpublikation

    DEFF Research Database (Denmark)

    Nejsum, Peter; Parker, E. Davis; Frydenberg, Jane;

    2006-01-01

    Forekomsten af humane spolorminfektioner (askariose) er tidligere forklaret ved, at smitten enten er erhvervet under udlandsrejser eller ved indtagelse af uforarbejdede levnedsmidler importeret fra lande, hvor sygdommen er almindeligt forekommende. Epidemiologiske undersøgelser udført i Viborg Am...

  1. SEC16 in COPII coat dynamics at ER exit sites

    NARCIS (Netherlands)

    Sprangers, Joep; Rabouille, Catherine

    2015-01-01

    Protein export from the endoplasmic reticulum (ER), the first step in protein transport through the secretory pathway, is mediated by coatomer protein II (COPII)-coated vesicles at ER exit sites. COPII coat assembly on the ER is well understood and the conserved large hydrophilic protein Sec16 clear

  2. Pathogenesis of PR3-ANCA associated vasculitis

    NARCIS (Netherlands)

    Kallenberg, C. G. M.

    2008-01-01

    Wegener's Granulomatosis (WG) is closely associated with antineutrophil cytoplasmic autoantibodies (ANCA), particularly those directed to proteinase 3 (PR3). ANCA directed to myeloperoxidase (MPO) are associated with microscopic polyangiitis (MPA) and the Churg Strauss syndrome. PR3-ANCA associated

  3. Cancer de la próstata

    OpenAIRE

    Mendoza, Lupi Alejandro; Fundación Valle de Lili; Gutierrez, María Carolina; López Cardona, Arturo

    1997-01-01

    ¿Qué es la próstata?/¿Qué es la hiperplasia benigna de próstata?/El cáncer de próstata/¿Se hereda el cáncer de próstata?/¿Cómo se presenta y hacia donde se disemina el cáncer de próstata?/¿Cómo de descubre el cáncer de próstata?/¿Qué estudia la ultrasonografía transrectal o ecografía a través de recto?/¿Cómo se analizan los niveles de PSA?/¿Cómo se clasifica el cáncer de próstata?¿Cómo se determina la terapia más adecuada para un cáncer de próstata?/¿Cuáles son las opciones de tratamiento par...

  4. Pathogenesis of PR3-ANCA associated vasculitis

    NARCIS (Netherlands)

    Kallenberg, C. G. M.

    2008-01-01

    Wegener's Granulomatosis (WG) is closely associated with antineutrophil cytoplasmic autoantibodies (ANCA), particularly those directed to proteinase 3 (PR3). ANCA directed to myeloperoxidase (MPO) are associated with microscopic polyangiitis (MPA) and the Churg Strauss syndrome. PR3-ANCA associated

  5. Préface :

    Directory of Open Access Journals (Sweden)

    Wolfgang Pfefferkorn

    2009-10-01

    Full Text Available Le présent numéro de la Revue de Géographie Alpine présente les projets et initiatives traitant de la gestion et du transfert des savoirs dans le contexte régional. Au cours des trente dernières années, l’importance des savoirs n’a cessé de croître, et ils constituent aujourd’hui une véritable ressource économique. Ainsi, dans une société où ils jouent un rôle primordial, ils représentent désormais un facteur de production. Aujourd’hui, tant dans le secteur public que privé, de nombreux salar...

  6. Progesterone receptor (PR) variants exist in breast cancer cells characterised as PR negative.

    Science.gov (United States)

    Cork, David M W; Lennard, Thomas W J; Tyson-Capper, Alison J

    2012-12-01

    Progesterone receptor (PR) expression is measured in breast cancer by immunohistochemistry using N-terminally targeted antibodies and serves as a biomarker for endocrine therapeutic decisions. Extensive PR alternative splicing has been reported which may generate truncated PR variant proteins which are not detected by current breast cancer screening or may alter the function of proteins detected in screening. However, the existence of such truncated PR variants remains controversial. We have characterised PR protein expression in breast cancer cell lines using commercial PR antibodies targeting different epitopes. Truncated PR proteins are detected in reportedly PR negative MDA-MB-231 cells using a C-terminally targeted antibody. Antibody specificity was confirmed by immunoblotting following siRNA knockdown of PR expression. We have further demonstrated that alternatively spliced PR mRNA is present in MDA-MB-231 cells and in reportedly PR-negative breast tumour tissue which could encode the truncated PR proteins detected by the C-terminal antibody. The potential function of PR variant proteins present in MDA-MB-231 cells was also assessed, indicating the ability of these PR variants to bind progesterone, interact with a nuclear PR co-factor and bind DNA. These findings suggest that alternative splicing may generate functional truncated PR variant proteins which are not detected by breast cancer screening using N-terminally targeted antibodies leading to misclassification as PR negative.

  7. Optical modulator including grapene

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Ming; Yin, Xiaobo; Zhang, Xiang

    2016-06-07

    The present invention provides for a one or more layer graphene optical modulator. In a first exemplary embodiment the optical modulator includes an optical waveguide, a nanoscale oxide spacer adjacent to a working region of the waveguide, and a monolayer graphene sheet adjacent to the spacer. In a second exemplary embodiment, the optical modulator includes at least one pair of active media, where the pair includes an oxide spacer, a first monolayer graphene sheet adjacent to a first side of the spacer, and a second monolayer graphene sheet adjacent to a second side of the spacer, and at least one optical waveguide adjacent to the pair.

  8. The Re-election of the Indonesian President: Reasons and Background Präsidentschaftswahlen in Indonesien: Ursachen und Hintergründe zur Wiederwahl Susilo Bambang Yudhoyonos

    Directory of Open Access Journals (Sweden)

    Patrick Ziegenhain

    2009-10-01

    Full Text Available Incumbent president Susilo Bambang Yudhoyono (SBY was re-elected as Indonesian president in the elections on 8 July 2009 with over 60 per cent of the votes. The reasons for the victory were his relatively successful economic policies, his efforts in the fight against corruption, and the poor quality of his political opponents. The retired general made a military career under the authoritarian New Order and then became a politician after democratisation started in 1998. In 2004, he was elected president with the support of Islamic parties, which he then included in his government. As a person close to the military, SBY avoided reducing the privileges of the Armed Forces and thus democratic deepening has been stalled. However, there are good chances that economic progress and political stability will prevail during his second term. Der amtierende Präsident Susilo Bambang Yudhoyono wurde in der Wahl am 8. Juli 2009 mit über 60% der Stimmen wiedergewählt. Gründe für den Wahlsieg waren seine relativ erfolgreiche Wirtschaftspolitik, seine Bemühungen im Kampf gegen die Korruption, aber auch die wenig Erfolg versprechenden Gegenkandidaten. Der General im Ruhestand machte unter der autoritären Neuen Ordnung Karriere bei den Streitkräften und wurde nach dem Beginn des Demokratisierungsprozesses im Jahr 1998 Politiker. Im Jahr 2004 wurde er mit der Unterstützung der islamischen Parteien zum Präsidenten Indonesiens gewählt. Als eine dem Militär nahestehende Person vermied er, die Privilegien der Streitkräfte zu reduzieren, was die Qualität der Demokratie nicht erhöhte. Dennoch stehen die Chancen gut, dass in seiner zweiten Amtszeit wirtschaftlicher Aufschwung und politische Stabilität anhalten werden.

  9. Hamlet er manden i mit liv

    DEFF Research Database (Denmark)

    Rösing, Lilian Munk

    2009-01-01

    Hamlet er manden i mit liv. Min elskede. Jeg har en drøm om at frelse ham. At redde ham ud af sin mors soveværelse og ind i mit. Væk fra det ødipale Helvede han befinder sig i, fastlåst mellem et svin af en faderskikkelse (Claudius) og en alt for idealiseret far (gamle Hamlet), vågende over sin...... jeg bare skrige tilbage at han var en håbløs lille Ødipus, og så kunne vi skændes inderligt og forsones ømt. Hamlet er min elskede. Og derfor græder jeg trøstesløst hver gang han dør, hver gang han hengiver sig til det store gruppeorgie af en mordscene hjemme hos mor og far, i stedet for at holde...

  10. Transverse Wobbling in $^{135}$Pr

    CERN Document Server

    Matta, J T; Li, W; Frauendorf, S; Ayangeakaa, A D; Patel, D; Schlax, K W; Palit, R; Saha, S; Sethi, J; Trivedi, T; Ghugre, S S; Raut, R; Sinha, A K; Janssens, R V F; Zhu, S; Carpenter, M P; Lauritsen, T; Seweryniak, D; Chiara, C J; Kondev, F G; Hartley, D J; Petrache, C M; Mukhopadhyay, S; Lakshmi, D Vijaya; Raju, M Kumar; Rao, P V Madhusudhana; Tandel, S K; Ray, S; Dönau, F

    2015-01-01

    A pair of transverse wobbling bands has been observed in the nucleus $^{135}$Pr. The wobbling is characterized by $\\Delta I$ =1, E2 transitions between the bands, and a decrease in the wobbling energy confirms its transverse nature. Additionally, a transition from transverse wobbling to a three-quasiparticle band comprised of strong magnetic dipole transitions is observed. These observations conform well to results from calculations with the Tilted Axis Cranking (TAC) model and the Quasiparticle Triaxial Rotor (QTR) Model.

  11. SYP73 Anchors the ER to the Actin Cytoskeleton for Maintenance of ER Integrity and Streaming in Arabidopsis.

    Science.gov (United States)

    Cao, Pengfei; Renna, Luciana; Stefano, Giovanni; Brandizzi, Federica

    2016-12-05

    The endoplasmic reticulum (ER) is an essential organelle that spreads throughout the cytoplasm as one interconnected network of narrow tubules and dilated cisternae that enclose a single lumen. The ER network undergoes extensive remodeling, which critically depends on membrane-cytoskeleton interactions [1]. In plants, the ER is also highly mobile, and its streaming contributes significantly to the movement of other organelles [2, 3]. The remodeling and motility of the plant ER rely mainly on actin [4] and to a minor extent on microtubules [5]. Although a three-way interaction between the ER, cytosolic myosin-XI, and F-actin mediates the plant ER streaming [6], the mechanisms underlying stable interaction of the ER membrane with actin are unknown. Early electron microscopy studies suggested a direct attachment of the plant ER with actin filaments [7, 8], but it is plausible that yet-unknown proteins facilitate anchoring of the ER membrane with the cytoskeleton. We demonstrate here that SYP73, a member of the plant Syp7 subgroup of SNARE proteins [9] containing actin-binding domains, is a novel ER membrane-associated actin-binding protein. We show that overexpression of SYP73 causes a striking rearrangement of the ER over actin and that, similar to mutations of myosin-XI [4, 10, 11], loss of SYP73 reduces ER streaming and affects overall ER network morphology and plant growth. We propose a model for plant ER remodeling whereby the dynamic rearrangement and streaming of the ER network depend on the propelling action of myosin-XI over actin coupled with a SYP73-mediated bridging, which dynamically anchors the ER membrane with actin filaments.

  12. Visual Impairment, Including Blindness

    Science.gov (United States)

    ... Who Knows What? Survey Item Bank Search for: Visual Impairment, Including Blindness Links updated, April 2017 En ... doesn’t wear his glasses. Back to top Visual Impairments in Children Vision is one of our ...

  13. Er energieffektivisering forgæves?

    DEFF Research Database (Denmark)

    Taudal Poulsen, René

    2016-01-01

    Olieprisens bølgegang giver rederierhvervet store muligheder og udfordringer. For to år siden lå prisen på en tønde olie over 100 dollars, og dengang var det vanskeligt at forestille sig et væsentligt fald inden for overskuelig fremtid. I løbet af det sidste halvandet år er vi imidlertid blevet...

  14. Pigen i papkassen er TV-speaker

    DEFF Research Database (Denmark)

    Henriksen, Carsten

    2011-01-01

    Børnehavebørn tager de første spæde skridt ind i skriftsproget, når de snakker det bedste, de har lært. Læring og skoleparathed i børnehaven handler ikke om at træne begynder-ABC, men om at opdage, hvordan skriftsproget er filtret sammen med talesproget, og stimulere det yderligere, mener Anders ...

  15. Sund livsstil er mere end fysik

    DEFF Research Database (Denmark)

    Nybo, Lars; Thing, Lone Friis; Astrup, Arne

    2015-01-01

    behandling af inaktivitetsrelaterede lidelser bør dog ikke være det vigtigste argument for at oplyse om og opfordre til en sund livsstil. Livskvalitetsaspektet skal være i højsædet, og det er for så vidt en legitim bekymring, at der kommer et overdrevet fokus på samfundsøkonomi og forebyggelse af somatisk...

  16. Er forbrugernes adfærd uforudsigelig?

    DEFF Research Database (Denmark)

    Brunsø, Karen

    2001-01-01

    Det bliver tit og ofte fremhævet, at forbrugerne er uforudsigelige i deres adfærd, herunder at de siger et og gør noget helt andet, når de står indkøbssituationen i supermarkedet. I samme åndedræt hævdes det, at forbrugerne handler ud fra følelsesmæssige impulser, og det har den konsekvens...

  17. En hat er vel en hat ... eller?

    DEFF Research Database (Denmark)

    Bøilerehauge, Dorrit

    2007-01-01

    Mens vi kører i høj fart på "the information highway" - i den helt store bus midt på vejen - glemmer vi ofte noget meget vigtigt i vores glæde over, at verden tilsyneladende åbner sig for os, og vi kan kommunikere med hele verden med ét klik. Vi glemmer, at selvom trafikskilte som oftest er ens...

  18. Pigen i papkassen er TV-speaker

    DEFF Research Database (Denmark)

    Henriksen, Carsten

    2011-01-01

    Børnehavebørn tager de første spæde skridt ind i skriftsproget, når de snakker det bedste, de har lært. Læring og skoleparathed i børnehaven handler ikke om at træne begynder-ABC, men om at opdage, hvordan skriftsproget er filtret sammen med talesproget, og stimulere det yderligere, mener Anders ...

  19. Electrorheological (ER) Fluids: A Research Needs Assessment

    Science.gov (United States)

    1993-05-01

    Accidental spillage must not create hazards to health or ecology . Safe means must be available for ultimate disposal of wornout or outmoded devices...the stiffness of airfoils, hydrofoils and structural members. Since the optimal stiffness of an airfoil varies with speed, ER modulation of the...stiffness could produce appreciable savings in propulsive energy. The same principle could apply to marine hydrofoils and to helicopter blades, again with

  20. Er det lovligt at opstille webcam

    DEFF Research Database (Denmark)

    Trzaskowski, Jan

    2003-01-01

    Idéen med at optage billeder og transmittere dem på Internettet er ingen ny opfindelse. Webcam har eksisteret i mange år. Udbredelsen af bredbånd har dog sat flere i stand til at etablere sig som udgiver af ”live” billeder på Internettet. Det være sig som løbende opdaterede still-billeder eller...

  1. Virtual Reality er dit nye Skype

    DEFF Research Database (Denmark)

    Bødker, Mads

    2016-01-01

    VR er mediet, der kan gøre den flade skærm og det begrænsede blik i for eksempel Skype til et lidt gammeldags digitalt samarbejde. Ved at sætte folk i stand til at kommunikere, dele virtuelle genstande og give dem en øget oplevelse af at være i et rum sammen, kan man mediere nye aspekter af samar...

  2. Her er din motion i 2012

    DEFF Research Database (Denmark)

    Suhr, Lasse Kristian

    2014-01-01

    Motion i naturen, en indendørs fitnessform inspireret af junglens lianer og høj intensitet med crossfit. Det er ifølge en ekspert nogle af de træningstyper, der vil være mest populære i 2012. Året hvor fleksibilitet og frihed vil blive endnu vigtigere, for den måde vi holder os i form på....

  3. Homeostatic regulation of the PI(4,5)P2-Ca(2+) signaling system at ER-PM junctions.

    Science.gov (United States)

    Chang, Chi-Lun; Liou, Jen

    2016-08-01

    The phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-Ca(2+) signaling system is important for cell activation in response to various extracellular stimuli. This signaling system is initiated by receptor-induced hydrolysis of PI(4,5)P2 in the plasma membrane (PM) to generate the soluble second messenger inositol 1,4,5-trisphosphate (IP3). IP3 subsequently triggers the release of Ca(2+) from the endoplasmic reticulum (ER) store to the cytosol to activate Ca(2+)-mediated responses, such as secretion and proliferation. The consumed PM PI(4,5)P2 and ER Ca(2+) must be quickly restored to sustain signaling responses, and to maintain the homeostasis of PI(4,5)P2 and Ca(2+). Since phosphatidylinositol (PI), the precursor lipid for PM PI(4,5)P2, is synthesized in the ER membrane, and a Ca(2+) influx across the PM is required to refill the ER Ca(2+) store, efficient communications between the ER and the PM are critical for the homeostatic regulation of the PI(4,5)P2-Ca(2+) signaling system. This review describes the major findings that established the framework of the PI(4,5)P2-Ca(2+) signaling system, and recent discoveries on feedback control mechanisms at ER-PM junctions that sustain the PI(4,5)P2-Ca(2+) signaling system. Particular emphasis is placed on the characterization of ER-PM junctions where efficient communications between the ER and the PM occur, and the activation mechanisms of proteins that dynamically localize to ER-PM junctions to provide the feedback control during PI(4,5)P2-Ca(2+) signaling, including the ER Ca(2+) sensor STIM1, the extended synaptotagmin E-Syt1, and the PI transfer protein Nir2. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon.

  4. Nominal Anglicisms in -er in Serbian

    Directory of Open Access Journals (Sweden)

    Štasni Gordana R.

    2015-01-01

    Full Text Available This paper gives an account of morphological-derivational and semantic characteristics of the nominal Anglicisms ending in -er, how they entered the Serbian language, the degree of their integration and their place in the lexicon. Typically, those are nouns pertaining to the nomina agentis, nomina professionis and nomina instrumenti categories, which belong to the general wordstock or the terminological systems. They are mainly obvious and justified Anglicisms which are highly integrated into the language. The analysis shows that these units enter Serbian isolatedly (broker, revolver, brauzer or together with other semantically or derivationally related Anglicisms (pejdžer - pejdžing, kidnapovati - kidnaper, džogirati - džoger - džoging. The Anglicisms ending in -er which entered Serbian isolatedly are usually not subject to further derivation as a form of secondary adaptation. On the other hand, if the Anglicisms enter as parts of a series, every member has the capacity for derivation varieties, e.g. skenirati [skener] > skeniranje, tenis [teniser] > teniski, teniser > teniserski, teniserka. The extent to which these Anglicisms are integrated into the system of the recipient language is confirmed by their capacity for further semantic variations (using different mechanisms, and reflects on their tendency to form paradigmatic relations with native and nativized units. [Projekat Ministarstva nauke Republike Srbije, br. 178004: Istraživanje je rađeno u okviru projekta Standardni srpski jezik: sintaksička, semantička i pragmatička istraživanja

  5. The Application of Survey in ER Wang Temple Restituting

    Science.gov (United States)

    Shuai, W.; Rong, Z.

    2013-07-01

    Er Wang Temple, in World Heritage Site "Dujiang Weirs and Qingchengshan Mountai", was severely destroyed in Wenchuan earthquake of May 2008. There are several problems at different level in every building, such as structural distortion, foundation displacement, wall fracture, roof damage, etc. The stage was completely collapsed in the earthquake. Tableland the stage situated had a huge crack and slope collapse. This article is for the stage renovation. The survey of damage in earthquake is the basis of Er Wang Temple restituting. Survey including field survey after the earthquake and the measurement and investigation for the remained construction member of the main wood structure. For field survey, the basis of pillars which had not have significantly affects in earthquake could be seem as the reference points for measurement. The investigation of remained main wood construction member, especially the size of the key structures and site and manufacture method of the joints, is the important basis for recovery stage. Our team did our utmost to restore the original appearance of stage in design, materials and craft by various tools, which include measured drawings in different times, old images collection, fine measuring by 3D laser scan, measurement of leftover pieces, logical inference.

  6. Paliperidone ER and oral risperidone in patients with schizophrenia: a comparative database analysis

    Directory of Open Access Journals (Sweden)

    Schooler Nina

    2011-02-01

    Full Text Available Abstract Background To compare the efficacy and tolerability of paliperidone extended-release (ER with risperidone immediate-release using propensity score methodology. Methods Six double-blind, randomized, placebo-controlled, short-term clinical trials for acute schizophrenia with availability of individual patient-level data were identified (3 per compound. Propensity score pairwise matching was used to balance observed covariates between the paliperidone ER and risperidone patient populations. Scores were generated using logistic regression models, with age, body mass index, race, sex, baseline Positive and Negative Syndrome Scale (PANSS total score and baseline Clinical Global Impressions–Severity (CGI-S score as factors. The dosage range of paliperidone ER (6-12 mg/day was compared with 2 risperidone dosage ranges: 2-4 and 4-6 mg/day. The primary efficacy measure was change in PANSS total score at week 6 end point. Tolerability end points included adverse event (AE reports and weight. AEs with rates ≥5% and with a ≥2% difference between paliperidone ER and risperidone were identified. Results Completion rates for placebo-treated subjects in paliperidone ER trials (n = 95 and risperidone trials (n = 122 groups were 36.8% and 51.6%, respectively; end point changes on PANSS total scores were similar (p = 0.768. Completion rates for subjects receiving paliperidone ER 6-12 mg/day (n = 179, risperidone 2-4 mg/day (n = 113 or risperidone 4-6 mg/day (n = 129 were 64.8%, 54.0% and 66.7%, respectively (placebo-adjusted rates: paliperidone ER vs risperidone 2-4 mg/day, p = 0.005; paliperidone ER vs risperidone 4-6 mg/day, p = 0.159. PANSS total score improvement with paliperidone ER was greater than with risperidone 2-4 mg/day (difference in mean change score, -6.7; p Conclusions This indirect database analysis suggested that paliperidone ER 6-12 mg/day may be more efficacious than risperidone 2-4 mg/day and as efficacious as risperidone 4-6 mg

  7. MicroRNAs meet calcium: joint venture in ER proteostasis.

    Science.gov (United States)

    Finger, Fabian; Hoppe, Thorsten

    2014-11-04

    The endoplasmic reticulum (ER) is a cellular compartment that has a key function in protein translation and folding. Maintaining its integrity is of fundamental importance for organism's physiology and viability. The dynamic regulation of intraluminal ER Ca(2+) concentration directly influences the activity of ER-resident chaperones and stress response pathways that balance protein load and folding capacity. We review the emerging evidence that microRNAs play important roles in adjusting these processes to frequently changing intracellular and environmental conditions to modify ER Ca(2+) handling and storage and maintain ER homeostasis.

  8. Near-infrared to visible up-conversion emissions of Er3+ doped Al2O3 powders derived from the sol-gel method

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The Er3+ doped Al2O3 powders were prepared by the sol-gel method using the aluminium isopropoxide [Al(OC3H7)3]-derived Al2O3 sols with addition of the erbium nitrate [Er(NO3)3.5H2O]. The different phase structure, including three crystalline types of (Al,Er)2O3 phases, γ, θ, α, and two Er-Al-O phases, ErAlO3 and Al10Er6O24, was obtained with the 1 mol% Er3+ doped Al2O3 powders at the different sintering temperatures of 600―1200℃. The green and red up-conversion emissions centered at about 523, 545 and 660 nm, corresponding respectively to the 2H11/2, 4S3/2→4I15/2 and 4F9/2→4I15/2 transitions of Er3+, were detected by a 978 nm semiconductor laser diodes excitation. The phase structure and OH content had evident influence on the up-conversion emissions intensity. The maximum intensities of both the green and red emissions were obtained respectively for the Er3+ doped Al2O3 powders sintered at 1200 ℃, which was composed mainly of α-(Al,Er)2O3, less of ErAlO3 and Al10Er6O24 phases, and with the least OH content. The two-photon absorption up-conversion process was involved in the green and red up-conversion emissions of the Er3+ doped Al2O3 powders.

  9. Den filosofiske præstation

    DEFF Research Database (Denmark)

    Skytte Gørtz, Kim Erik

    Bogen gør op med forestillingen om, at filosoffen er uanvendelig i erhvervslivet. Den udfolder en erhvervsfilosofi og inddrager filosoffer som Kant, Hegel, Kierkegaard, Nietzsche, Heidegger og Deleuze......Bogen gør op med forestillingen om, at filosoffen er uanvendelig i erhvervslivet. Den udfolder en erhvervsfilosofi og inddrager filosoffer som Kant, Hegel, Kierkegaard, Nietzsche, Heidegger og Deleuze...

  10. Doping er en brik i russisk politik

    DEFF Research Database (Denmark)

    Bonde, Hans

    2016-01-01

    Præsident Putin har indset, at sporten med dens evne til at skabe begejstring og tilhørsforhold udgør et fantastisk middel til at opnå politisk goodwill, der går under den normale radar for, hvad der opfattes som politik....

  11. PWM Flow Rate Control of ER Valve and its Application to ER Actuator Control

    Science.gov (United States)

    Nakano, Masami; Minagawa, Shuji; Hagino, Katsuya

    The PWM (Pulse Width Modulation) control of ER valve consisting of two parallel electrodes has been investigated to continuously control the flow rate of an electrorheological (ER) suspension containing sulfonated polymer particles in silicone oil. PWM wave voltages are applied to the electrodes of the ER valve. It is possible to control continuously the flow rate by changing the duty ratio of the PWM wave from 1 to 0, where the duty ratio of 1 corresponds to the state to stop the flow. A miniature bellows actuator driven by a pair of PWM controlled ER valves has been developed, and the control characteristics of the actuator have been investigated. The duty ratios of both ER valves have been proposed to be changed alternately in proportion to the control voltage V to control the flow rate into and out of the bellows chamber, and also an overlap duty ratio Dov at V=0V has been introduced. The introduction of the overlap duty ratio Dov was found to be very important to smoothly control the actuator and to improve the control performance.

  12. Glimepiride reduces the expression of PrPc, prevents PrPSc formation and protects against prion mediated neurotoxicity in cell lines.

    Directory of Open Access Journals (Sweden)

    Clive Bate

    Full Text Available BACKGROUND: A hallmark of the prion diseases is the conversion of the host-encoded cellular prion protein (PrP(C into a disease related, alternatively folded isoform (PrP(Sc. The accumulation of PrP(Sc within the brain is associated with synapse loss and ultimately neuronal death. Novel therapeutics are desperately required to treat neurodegenerative diseases including the prion diseases. PRINCIPAL FINDINGS: Treatment with glimepiride, a sulphonylurea approved for the treatment of diabetes mellitus, induced the release of PrP(C from the surface of prion-infected neuronal cells. The cell surface is a site where PrP(C molecules may be converted to PrP(Sc and glimepiride treatment reduced PrP(Sc formation in three prion infected neuronal cell lines (ScN2a, SMB and ScGT1 cells. Glimepiride also protected cortical and hippocampal neurones against the toxic effects of the prion-derived peptide PrP82-146. Glimepiride treatment significantly reduce both the amount of PrP82-146 that bound to neurones and PrP82-146 induced activation of cytoplasmic phospholipase A(2 (cPLA(2 and the production of prostaglandin E(2 that is associated with neuronal injury in prion diseases. Our results are consistent with reports that glimepiride activates an endogenous glycosylphosphatidylinositol (GPI-phospholipase C which reduced PrP(C expression at the surface of neuronal cells. The effects of glimepiride were reproduced by treatment of cells with phosphatidylinositol-phospholipase C (PI-PLC and were reversed by co-incubation with p-chloromercuriphenylsulphonate, an inhibitor of endogenous GPI-PLC. CONCLUSIONS: Collectively, these results indicate that glimepiride may be a novel treatment to reduce PrP(Sc formation and neuronal damage in prion diseases.

  13. Predicting the consequences of selecting on PrP genotypes on PrP frequencies, performance and inbreeding in commercial meat sheep populations

    Directory of Open Access Journals (Sweden)

    Boulton Kay

    2007-11-01

    Full Text Available Abstract Selection programmes based on prion protein (PrP genotypes are being implemented for increasing resistance to scrapie. Commercial meat sheep populations participating in sire-referencing schemes were simulated to investigate the effect of selection on PrP genotypes on ARR and VRQ allele frequencies, inbreeding and genetic gain in a performance trait under selection. PrP selection strategies modelled included selection against the VRQ allele and in favour of the ARR allele. Assuming realistic initial PrP frequencies, selection against the VRQ allele had a minimal impact on performance and inbreeding. However, when selection was also in favour of the ARR allele and the frequency of this allele was relatively low, there was a loss of up to three to four years of genetic gain over the 15 years of selection. Most loss in gain occurred during the first five years. In general, the rate of inbreeding was reduced when applying PrP selection. Since animals were first selected on their PrP genotype before being selected on the performance trait, the intensity of selection on performance was weaker under PrP selection (compared with no PrP selection. Eradication of the VRQ allele or fixation of the ARR allele within 15 years of selection was possible only with PrP selection targeting all breeding animals.

  14. NEXT GENERATION ORAL PrEP: BEYOND TENOFOVIR

    Science.gov (United States)

    Abraham, Bisrat K.; Gulick, Roy

    2013-01-01

    Purpose Clinical trials of oral pre-exposure prophylaxis (PrEP) have focused testing on regimens of tenofovir (TDF) with or without emtricitabine (FTC). However, TDF may be associated with toxicities (renal, bone) and FTC may select for drug resistance. In this review, we discuss agents that might serve as alternatives to TDF/FTC for HIV prevention. Recent Findings Several drug characteristics are important to consider when selecting agents for PrEP with the most critical being safety, tolerability, adequate penetration into target tissues, prevention of HIV infection, and long lasting activity with convenient dosing. With these factors in mind, we review several potentially useful agents for PrEP. The first group includes drugs that are already FDA-approved (maraviroc, raltegravir) with attributes that make them attractive for PrEP. The second groups of drugs include investigational agents with long-lasting activities that are being developed in parenteral form (rilpivirine-long acting, S/GSK 1265744, ibalizumab). Summary Current research suggests there will be a broader array of PrEP drugs to choose from in the near future, thereby giving clinicians the flexibility to select agents that best suit the needs of their patient population. PMID:23032733

  15. AFFECTION OF ER FLUID ON STIFFNESS OF VIBRATION SYSTEM

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    On the application of an electric field, the mechanical properties of ER(Electro-rheological) fluid are very complex. The damping force of ER fluid is linear without electric field and is nonlinear when an electric field is applied. By increasing the strength of the electric field, the behavior of ER fluid changes from linear viscous to nonlinear viscoelastic-plastic. External electric fluid changes natural behavior of system with ER fluid besides the mechanical properties of ER fluid. The affect of ER fluid on the stiffness of nonlinear vibration system with ER dampers is analyzed by iterative perturbation method. The results show that the stiffness of structure would be increased with growing of the strength of the electric field.

  16. Practice-Relevant Aspects of Constructing ER Fluid Actuators

    Science.gov (United States)

    Janocha, H.; Rech, B.; Bölter, R.

    The flow resistance of electrorheological fluids (ER fluids) can be controlled by applying electric fields. Thus, ER fluids are suitable for the application in actuators, using high-voltage sources for the generation of the field. The behaviour of an ER fluid actuator not only depends on the properties of the individual actuator components (ER fluid, energy transducer and energy source) but especially on their combined efforts as a system. Based on a possible scheme for the design of ER fluid actuators, this paper presents important practice-relevant aspects of a systematic actuator construction. Here the behaviour of a commercial ER suspension is examined and compared to a homogeneous ER fluid without yield point using a rotational viscometer and a flow-mode damper realized at the Laboratory of Process Automation (LPA) of the University of Saarland.

  17. Láser Er:YAG en Periodoncia: Revisión bibliográfica

    Directory of Open Access Journals (Sweden)

    A Herrero Sánchez

    2002-07-01

    Full Text Available Diferentes láseres, como el CO2, Nd:YAG y ArF se han propuesto en la terapéutica periodontal. La mayor parte de ellos no han alcanzado relevancia clínica, debido a los resultados insatisfactorios obtenidos en las superficies radiculares tratadas, la generación de efectos colaterales o la ausencia de terminales de aplicación adecuados. Sin embargo, el nuevo láser Er:YAG se muestra como una prometedora alternativa en la remoción de placa bacteriana y cálculo de las superficies radiculares afectas, gracias a su mecanismo de ablación termomecánica y a la ausencia de efectos térmicos secundarios. El propósito de este artículo es revisar las actuales aplicaciones del láser Er:YAG en la práctica periodontal.Different lasers, such as CO2, the Nd:YAG and the ArF have been proposed for use in periodontal therapy. Most systems have not reached clinical significance because of the unsattisfactory results of laser treated root surfaces, emergence of severe side effects, or the lack of suitable delivery systems. However, the recently introduced Er:YAG laser radiation appears to be a promising alternative means of removing microbial plaque and calculus from diseased tooth root surfaces, due to its thermo-mechanical ablation properties and the lack of thermal side effects. The purpose of this article is to review current applications of laser Er:YAG to periodontal practice.

  18. Vybrané aspekty PR komunikace firem

    OpenAIRE

    Bubeníková, Lenka

    2015-01-01

    The aim of this thesis is to identify opportunities and ways of using blogs for marketing purposes, to give a basic overview of the state of the blogospere in the Czech republic and to evaluate the importance of blogs as a PR tool. The thesis is divided into 2 parts - theoretical a practical. The theoretical part deals with the topic PR, its definition, pros and cons, classification, strategical PR process, PR tools, evaluation of efectiveness and PR on the Internet. The following chapter is ...

  19. Æstetik er tilbage som nøgle til at forstå samtiden

    DEFF Research Database (Denmark)

    Sharma, Devika

    2013-01-01

    Casper Christensen er gakket, Hello Kitty er nuttet og konceptkunsten er interessant. Her er tre nye kategorier at forstå senkapitalismen med. I anledning af Sianne Ngais bog "Our aesthetic categories: zany, cute, interesting" .......Casper Christensen er gakket, Hello Kitty er nuttet og konceptkunsten er interessant. Her er tre nye kategorier at forstå senkapitalismen med. I anledning af Sianne Ngais bog "Our aesthetic categories: zany, cute, interesting" ....

  20. Æstetik er tilbage som nøgle til at forstå samtiden

    DEFF Research Database (Denmark)

    Sharma, Devika

    2013-01-01

    Casper Christensen er gakket, Hello Kitty er nuttet og konceptkunsten er interessant. Her er tre nye kategorier at forstå senkapitalismen med. I anledning af Sianne Ngais bog "Our aesthetic categories: zany, cute, interesting" .......Casper Christensen er gakket, Hello Kitty er nuttet og konceptkunsten er interessant. Her er tre nye kategorier at forstå senkapitalismen med. I anledning af Sianne Ngais bog "Our aesthetic categories: zany, cute, interesting" ....

  1. Anomalous behaviors in resistivity and magnetization of reduction-treated multi phase ceramics of Pr124/Pr123 and inhomogeneous Pr247

    Energy Technology Data Exchange (ETDEWEB)

    Hagiwara, M., E-mail: hag@kit.ac.j [Faculty of Engineering and Design, Kyoto Institute of Technology, Kyoto (Japan); Shima, T. [Advanced Technology Center, Kyoto Institute of Technology, Kyoto (Japan); Tanaka, S. [Faculty of Engineering and Design, Kyoto Institute of Technology, Kyoto (Japan); Koyama, K. [Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima (Japan)

    2010-12-15

    A superconductive sign found in electric resistivity behavior of mixed ceramic Pr124/Pr123 is searched and discussed, to advance preceding discussion about the superconductive region induced by intergrain charge transfer effect in ceramic Pr247 containing the related impurity phases. Observed reduction effects for largely impure ceramic of Pr247 with Pr124 and Pr123 and for simply dual-phase sample of Pr124/Pr123 inform us that the oxygen-reduction brings not only superconductive electron doping but also normal resistivity enhancement. Milder heat treatment condition is expected to assist possible attainment of zero-resistivity for Pr124/Pr123.

  2. Analytic device including nanostructures

    KAUST Repository

    Di Fabrizio, Enzo M.

    2015-07-02

    A device for detecting an analyte in a sample comprising: an array including a plurality of pixels, each pixel including a nanochain comprising: a first nanostructure, a second nanostructure, and a third nanostructure, wherein size of the first nanostructure is larger than that of the second nanostructure, and size of the second nanostructure is larger than that of the third nanostructure, and wherein the first nanostructure, the second nanostructure, and the third nanostructure are positioned on a substrate such that when the nanochain is excited by an energy, an optical field between the second nanostructure and the third nanostructure is stronger than an optical field between the first nanostructure and the second nanostructure, wherein the array is configured to receive a sample; and a detector arranged to collect spectral data from a plurality of pixels of the array.

  3. Characterization of early transient accumulation of PrP(Sc) in immune cells.

    Science.gov (United States)

    Elhelaly, Abdelazim Elsayed; Inoshima, Yasuo; Ishiguro, Naotaka

    2013-09-27

    PrP(Sc) is known to elicit no specific immune response and the immune cells are suspected to support its accumulation. In the present study, we investigated the response of some immune cell types to PrP(Sc) to characterize an observed early transient accumulation of PrP(Sc). After cells were treated with PrP(Sc)-brain homogenate, PrP(Sc) was transiently accumulated for the first 8-12h post-exposure then completely cleared by the 5th day of the experiment. The accumulated PrP(Sc) was not a de novo product of the cell PrP(C). Further investigation of this phenomenon revealed some potential factors influencing it. These factors included cholesterol homeostasis, temperature, the degradation power of the cell and the availability of sufficient PrP(C). Our in vitro results suggest that immune cells, especially macrophages are potential risk factors for the accumulation and intercellular spread of PrP(Sc) if the complete clearance of PrP(Sc) were not fulfilled.

  4. Relationship between RUNX1 and AXIN1 in ER-negative versus ER-positive Breast Cancer.

    Science.gov (United States)

    Chimge, Nyam-Osor; Ahmed-Alnassar, Sara; Frenkel, Baruch

    2017-02-16

    RUNX1 plays opposing roles in breast cancer: a tumor suppressor in estrogen receptor-positive (ER(+)) disease and an oncogenic role in ER-negative (ER(-)) tumors. Potentially mediating the former, we have recently reported that RUNX1 prevents estrogen-driven suppression of the mRNA encoding the tumor suppressor AXIN1. Accordingly, AXIN1 protein expression was diminished upon RUNX1 silencing in ER(+) breast cancer cells and was positively correlated with AXIN1 protein expression across tumors with high levels of ER. Here we report the surprising observation that RUNX1 and AXIN1 proteins are strongly correlated in ER(-) tumors as well. However, this correlation is not attributable to regulation of AXIN1 by RUNX1 or vice versa. The unexpected correlation between RUNX1, playing an oncogenic role in ER(-) breast cancer, and AXIN1, a well-established tumor suppressor hub, may be related to a high ratio between the expression of variant 2 and variant 1 (v2/v1) of AXIN1 in ER(-) compared with ER(+) breast cancer. Although both isoforms are similarly regulated by RUNX1 in estrogen-stimulated ER(+) breast cancer cells, the higher v2/v1 ratio in ER(-) disease is expected to weaken the tumor suppressor activity of AXIN1 in these tumors.

  5. Completion Report for Well ER-8-1

    Energy Technology Data Exchange (ETDEWEB)

    Bechtel Nevada

    2004-11-01

    Well ER-8-1 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in October and November of 2002 as part of a Hydrogeologic investigation program for the Yucca Flat/Climax Mine Corrective Action Unit in the northeastern portion of the Nevada Test Site. Well ER-8-1 is located at the north end of Yucca Flat approximately 580 meters south-southeast of the surface exposure of the Climax granitic intrusive. Detailed lithologic descriptions with stratigraphic assignments are included in this report. These are based on composite drill cuttings samples collected every 3 meters, and 21 sidewall samples taken at various depths between 351.1 and 573.0 meters, supplemented by incomplete geophysical log data. Detailed petrographic, geochemical, and mineralogical studies of rock samples were conducted on 22 samples of drill cuttings. Drilling began in tuffaceous alluvium, and the borehole penetrated Tertiary age bedded tuffs of the Volcanics of Oak Spring Butte and carbonate sediments of Paleozoic age, which were encountered at a depth of 334 meters. The borehole unexpectedly penetrated granite at the depth of 538.9 meters in which drilling was stopped. Contact metamorphic rocks and intrusive dikes associated with the Cretaceous-age granitic intrusive and at least one significant fault zone were encountered.

  6. Completion Report for Well ER-2-1

    Energy Technology Data Exchange (ETDEWEB)

    Bechtel Nevada

    2004-10-01

    Well ER-2-1 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (formerly Nevada Operations Office), in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in February and March of 2003, as part of a hydrogeologic investigation program for the Yucca Flat/Climax Mine Corrective Action Unit in the northeastern portion of the Nevada Test Site. Well ER-2-1 was drilled as part of the Yucca Flat Corrective Action Unit Phase I drilling initiative. The well is located in north central Yucca Flat within Area 2 of the Nevada Test Site, and provided information regarding the radiological and physical environment near underground nuclear tests conducted in a saturated volcanic aquifer setting. Detailed lithologic descriptions with stratigraphic assignments are included in this report. These are based on composite drill cuttings collected every 3 meters and 83 sidewall samples taken at various depths between 113.7 and 754.4 meters, supplemented by geophysical log data. Detailed petrographic, chemical, and mineralogical studies of rock samples were conducted on 27 samples of drill cuttings. The well was collared in tuffaceous alluvium, and penetrated Tertiary-age tuffs of the Timber Mountain and Paintbrush Groups, Calico Hills and Wahmonie Formations, Crater Flat Group, Grouse Canyon Formation, before reaching total depth in the Tunnel Bed Formation.

  7. ER dampers in vibroprotection systems of precision equipment

    Science.gov (United States)

    Korobko, Evguenia V.; Shulman, Zinovy P.; Danilevski, Leonid N.

    1998-06-01

    The increased requirements on the accuracy of measurements with the aid of large-weight electronic-optical devices have entailed heavy demands for their efficient protection against low-vibration vibrations produced by an occasional external load or operator's pushes. In these cases, the means of active protection against vibrations used, e.g., in adjustment stands are considered to be the most efficient ones. Among actuating mechanisms of such systems, i.e. hydro- and pneumohydraulic, electromechanical and friction devices, the viscous-friction dampers show much promise since use of electrorheological fluids in the latter allows their functional capabilities to be extended owing to control of the elastoviscous parameters of a working fluid. An analysis is made of vibrations of a single-mass system (an electronic microscope column) whose vibroprotection scheme includes four ER-dampers. Their control is accomplished by a voltage unit in discrete as well as in follow-up linear and logarithmic regimes. The results obtained are compared with experimental data for the systems without dampers, with passive dampers and controllable ER-dampers. The latter are shown to be advantageous, in particular, a three- fold decrease of the Q-factor of the system under forced vibration is reached in the optimum control.

  8. 20 CFR 228.17 - Adjustments to the widow(er)'s, disabled widow(er)'s, surviving divorced spouse's, and remarried...

    Science.gov (United States)

    2010-04-01

    ... widow(er)'s, surviving divorced spouse's, and remarried widow(er)'s tier I annuity amount. 228.17..., disabled widow(er)'s, surviving divorced spouse's, and remarried widow(er)'s tier I annuity amount. (a) If...), remarried widow(er), or surviving divorced spouse is first eligible after 1984, the Board will compute...

  9. MappERS-C and MappERS-V. The crowd source for prevention and crisis support

    Science.gov (United States)

    Frigerio, Simone; Schenato, Luca; Bianchizza, Chiara; Del Bianco, Daniele

    2015-04-01

    The responsibilities within natural hazards at local/regional levels involve citizens and volunteers as first actors of civil protection and territorial management. The prevention implicates the capacities of professional operators and technical volunteers, but the priority implies now the involvement and awareness of the citizens over the territory they inhabit. The involvement of population creates context-specific strategies of territorial surveillance and management, skipping the limit to face risks only when they have to bear impacts on their lives. MAppERS (Mobile Application for Emergency Response and Support) is a EU project (funded under programme 2013-2015 Humanitarian Aid and Civil Protection, ECHO A5) which empowers "crowd-sourced mappers" through smart phone applications and sensors, with geo-tagged information, detailed gathered parameters, field-check survey in a contest of geospatial response. The process of development includes feedback from citizens, involving them in training courses on the monitoring as long term objective (raising public awareness and participation). The project deals with the development and testing of the smart phone applications (module MAppERS-V for volunteers, module MAppERS-C for citizens) according to Android SDK environment. A first research described a desk-based investigation on consequences of disasters impacts and costs of prevention strategies in pilot countries. Furthermore a review of state-of-the-art of database management systems (DBMS) in pilot countries and involvement of volunteers/citizens in data collection/monitoring collected basic info on data structure for the development. A desk-based research proposed communication methods/graphic solutions within mobile technologies for disaster management in pilot countries and available smartphone applications linked to centralized web/server database. A technical review is compulsory for a useful design-line for MappERS development, and it is linked with on

  10. The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis

    Directory of Open Access Journals (Sweden)

    Vedrana eTadic

    2014-05-01

    Full Text Available Amyotrophic lateral sclerosis (ALS is a neurodegenerative disease characterized by progressive loss of upper and lower motor neurons. Although the etiology remains unclear, disturbances in calcium homoeostasis and protein folding are essential features of neurodegeneration in this disorder. Here, we review recent research findings on the interaction between endoplasmic reticulum (ER and mitochondria, and its effect on calcium signaling and oxidative stress. We further provide insights into studies, providing evidence that structures of the ER mitochondria calcium cycle (ERMCC serve as a promising targets for therapeutic approaches for treatment of ALS.

  11. On the Use of an ER-213 Detonator to Establish a Baseline for the ER-486

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, Keith A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Liechty, Gary H. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jaramillo, Dennis C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Munger, Alan C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); McHugh, Douglas C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kennedy, James E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-08-19

    This report documents a series of tests using a TSD-115 fireset coupled with an ER-213, a gold exploding bridgewire (EBW) detonator. These tests were designed to fire this EBW with a smaller fireset to obtain current and voltage data as well as timing information at voltage levels below, above, and throughout the threshold firing region. This study could then create a database for comparison to our current ER-486 EBW development, which is designed to be a lower voltage (<500V) device.

  12. The ER-mitochondria interface: the social network of cell death.

    Science.gov (United States)

    Grimm, Stefan

    2012-02-01

    When cellular organelles communicate bad things can happen. Recent findings uncovered that the junction between the endoplasmic reticulum (ER) and the mitochondria holds a crucial role for cell death regulation. Not only does this locale connect the two best-known organelles in apoptosis, numerous regulators of cell death are concentrated at this spot, providing a terrain for intense signal transfers. Ca2+ is the most prominent signalling factor that is released from the ER and, at high concentration, mediates the transfer of an apoptosis signal to mitochondria as the executioner organelle for cell death. An elaborate array of checks and balances is fine-tuning this process including Bcl-2 family members. Moreover, MAMs, "mitochondria-associated membranes", are distinct membrane sections at the ER that are in close contact with mitochondria and have been found to exchange lipids and lipid-derived molecules such as ceramide for apoptosis induction. Recent work has also described a reverse transfer of apoptosis signals, from mitochondria to the ER, via cytochrome c release and prolonged IP3R opening or through the mitochondrial fission factor Fis1 and Bap31 at the ER, which form the ARCosome, a novel caspase-activation complex.

  13. CK2 phosphorylates Sec31 and regulates ER-To-Golgi trafficking.

    Directory of Open Access Journals (Sweden)

    Mayuko Koreishi

    Full Text Available Protein export from the endoplasmic reticulum (ER is an initial and rate-limiting step of molecular trafficking and secretion. This is mediated by coat protein II (COPII-coated vesicles, whose formation requires small GTPase Sar1 and 6 Sec proteins including Sec23 and Sec31. Sec31 is a component of the outer layer of COPII coat and has been identified as a phosphoprotein. The initiation and promotion of COPII vesicle formation is regulated by Sar1; however, the mechanism regulating the completion of COPII vesicle formation followed by vesicle release is largely unknown. Hypothesizing that the Sec31 phosphorylation may be such a mechanism, we identified phosphorylation sites in the middle linker region of Sec31. Sec31 phosphorylation appeared to decrease its association with ER membranes and Sec23. Non-phosphorylatable mutant of Sec31 stayed longer at ER exit sites and bound more strongly to Sec23. We also found that CK2 is one of the kinases responsible for Sec31 phosphorylation because CK2 knockdown decreased Sec31 phosphorylation, whereas CK2 overexpression increased Sec31 phosphorylation. Furthermore, CK2 knockdown increased affinity of Sec31 for Sec23 and inhibited ER-to-Golgi trafficking. These results suggest that Sec31 phosphorylation by CK2 controls the duration of COPII vesicle formation, which regulates ER-to-Golgi trafficking.

  14. Thermodynamic assessment of Au-La and Au-Er binary systems

    Energy Technology Data Exchange (ETDEWEB)

    Dong, H.Q., E-mail: hongqun.dong@aalto.fi [Department of Electronics, Aalto University School of Science and Technology, FIN-02601 Espoo (Finland); Tao, X.M. [Key Laboratory of New Processing Technology for Nonferrous Metals and Materials of Ministry of Education, Department of Physics, Guangxi University, Nanning 530004 (China); Liu, H.S. [Scientific Center of Phase Diagrams and Materials Design, Central South University, Changsha, Hunan 410083 (China); Laurila, T.; Paulastro-Kroeckel, M. [Department of Electronics, Aalto University School of Science and Technology, FIN-02601 Espoo (Finland)

    2011-03-31

    Research highlights: > It's the first time that Au-La and Au-Er binary systems were thermodynamically assessed since 1985. > Besides, in the present work, the ab initio approach has been employed to calculate the formation enthalpies of the IMCs involved in Au-Er and Au-La binary systems, and then, by combining with all of the available experimental information, these two-system were thermodynamically optimized via CALPHAD method. Therefore, a more reliable thermodynamic description has been obtained for these systems. - Abstract: Phase relationships in Au-La and Au-Er binary systems have been thermodynamically assessed by using the CALPHAD technique. The existing thermodynamic descriptions of the systems were improved by incorporating the ab initio calculated enthalpies of formation of the intermetallic compounds, except for the Au{sub 51}La{sub 14} and Au{sub 10}Er{sub 7} phases. All the binary intermetallic compounds were treated as stoichiometric phases, while the solution phases, including liquid, fcc, bcc, and dhcp, were treated as substitutional solution phases and the excess Gibbs energies were formulated with Redlich-Kister polynomial function. As a result, two self-consist thermodynamic data sets for describing the Au-La and Au-Er binary systems were obtained.

  15. Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and Golgi.

    Science.gov (United States)

    Schumacher, Marc M; Jun, Dong-Jae; Jo, Youngah; Seemann, Joachim; DeBose-Boyd, Russell A

    2016-07-01

    UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K2 subtype menaquinone-4. Previously, we found that sterols trigger binding of UBIAD1 to endoplasmic reticulum (ER)-localized HMG-CoA reductase, the rate-limiting enzyme in synthesis of cholesterol and nonsterol isoprenoids, including GGpp. This binding inhibits sterol-accelerated degradation of reductase, which contributes to feedback regulation of the enzyme. The addition to cells of geranylgeraniol (GGOH), which can become converted to GGpp, triggers release of UBIAD1 from reductase, allowing for its maximal degradation and permitting ER-to-Golgi transport of UBIAD1. Here, we further characterize geranylgeranyl-regulated transport of UBIAD1. Results of this characterization support a model in which UBIAD1 continuously cycles between the ER and medial-trans Golgi of isoprenoid-replete cells. Upon sensing a decline of GGpp in ER membranes, UBIAD1 becomes trapped in the organelle where it inhibits reductase degradation. Mutant forms of UBIAD1 associated with Schnyder corneal dystrophy (SCD), a human eye disease characterized by corneal accumulation of cholesterol, are sequestered in the ER and block reductase degradation. Collectively, these findings disclose a novel sensing mechanism that allows for stringent metabolic control of intracellular trafficking of UBIAD1, which directly modulates reductase degradation and becomes disrupted in SCD.

  16. FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKKβ pathways.

    Science.gov (United States)

    Jiao, Ping; Ma, Jie; Feng, Bin; Zhang, Hao; Diehl, J Alan; Chin, Y Eugene; Yan, Weiqun; Xu, Haiyan

    2011-03-01

    Free-fatty acids (FFAs) are well-characterized factor for causing production of inflammatory factors and insulin resistance in adipocytes. Using cultured adipocytes, we demonstrate that FFAs can activate endoplasmic reticulum (ER) stress pathway by examination of ER stress sensor activation and marker gene expression. Chemical chaperone tauroursodeoxycholic acid (TUDCA) can reduce FFA-induced adipocyte inflammation and improve insulin signaling whereas overexpression of spliced X-box protein 1 (XBP-1s) only attenuates FFA-induced inflammation. PKR-like eukaryotic initiation factor 2α kinase (PERK) is one of the three major ER stress sensor proteins and deficiency of PERK alleviates FFA-induced inflammation and insulin resistance. The key downstream target of FFA-induced ER stress is IκB kinase β (IKKβ), a master kinase for regulating expression of inflammatory genes. Deficiency of PERK attenuates FFA-induced activation of IKKβ and deficiency of IKKβ alleviates FFA-induced inflammation and insulin resistance. Consistently, overexpression of IKKβ in 3T3-L1 CAR adipocytes causes inflammation and insulin resistance. In addition, IKKβ overexpression has profound effect on adipocyte lipid metabolism, including inhibition of lipogenesis and promotion of lipolysis. Furthermore, increased endogenous IKKβ expression and activation is also observed in isolated primary adipocytes from mice injected with lipids or fed on high-fat diet (HFD) acutely. These results indicate that ER stress pathway is a key mediator for FFA-induced inflammation and insulin resistance in adipocytes with PERK and IKKβ as the critical signaling components.

  17. A Novel Surgical Procedure for Er:YAG Laser-Assisted Periodontal Regenerative Therapy: Case Series.

    Science.gov (United States)

    Taniguchi, Yoichi; Aoki, Akira; Sakai, Kazuto; Mizutani, Koji; Meinzer, Walter; Izumi, Yuichi

    2016-01-01

    The objective of this study was to evaluate an Er:YAG laser (ErL) application for periodontal regenerative surgery in angular bone defects at nine sites in six patients. Debridement was thoroughly performed using a combination of curettage with a Gracey-type curette and ErL irradiation at a panel setting of 70 mJ/pulse and 20 Hz with sterile saline spray. After applying an enamel matrix derivative and autogenous bone grafting, ErL was used to form a blood clot coagulation on the grafted bone surface at 50 mJ/pulse and 20 Hz without water spray for approximately 30 seconds. Twelve months after surgery the mean probing depth had improved from 6.2 mm to 2.0 mm, the mean clinical attachment level had reduced from 7.5 mm to 3.4 mm, and bleeding on probing had improved from (+) to (-). Mean intrabony defect depth decreased from 6.0 mm before surgery to 1.0 mm 12 months after surgery. A novel procedure for periodontal regenerative surgery applying ErL irradiation for thorough decontamination during debridement as well as blood coagulation following autogenous bone grafting seems to have achieved favorable and stable healing of periodontal pockets with significant clinical improvement and desirable regeneration of angular bone defects, including one-wall defects.

  18. Gene expression profiling analysis of bisphenol A-induced perturbation in biological processes in ER-negative HEK293 cells.

    Directory of Open Access Journals (Sweden)

    Rong Yin

    Full Text Available Bisphenol A (BPA is an environmental endocrine disruptor which has been detected in human bodies. Many studies have implied that BPA exposure is harmful to human health. Previous studies mainly focused on BPA effects on estrogen receptor (ER-positive cells. Genome-wide impacts of BPA on gene expression in ER-negative cells is unclear. In this study, we performed RNA-seq to characterize BPA-induced cellular and molecular impacts on ER-negative HEK293 cells. The microscopic observation showed that low-dose BPA exposure did not affect cell viability and morphology. Gene expression profiling analysis identified a list of differentially expressed genes in response to BPA exposure in HEK293 cells. These genes were involved in variable important biological processes including ion transport, cysteine metabolic process, apoptosis, DNA damage repair, etc. Notably, BPA up-regulated the expression of ERCC5 encoding a DNA endonuclease for nucleotide-excision repair. Further electrochemical experiment showed that BPA induced significant DNA damage in ER-positive MCF-7 cells but not in ER-negative HEK293 cells. Collectively, our study revealed that ER-negative HEK293 cells employed mechanisms in response to BPA exposure different from ER-positive cells.

  19. Gene expression profiling analysis of bisphenol A-induced perturbation in biological processes in ER-negative HEK293 cells.

    Science.gov (United States)

    Yin, Rong; Gu, Liang; Li, Min; Jiang, Cizhong; Cao, Tongcheng; Zhang, Xiaobai

    2014-01-01

    Bisphenol A (BPA) is an environmental endocrine disruptor which has been detected in human bodies. Many studies have implied that BPA exposure is harmful to human health. Previous studies mainly focused on BPA effects on estrogen receptor (ER)-positive cells. Genome-wide impacts of BPA on gene expression in ER-negative cells is unclear. In this study, we performed RNA-seq to characterize BPA-induced cellular and molecular impacts on ER-negative HEK293 cells. The microscopic observation showed that low-dose BPA exposure did not affect cell viability and morphology. Gene expression profiling analysis identified a list of differentially expressed genes in response to BPA exposure in HEK293 cells. These genes were involved in variable important biological processes including ion transport, cysteine metabolic process, apoptosis, DNA damage repair, etc. Notably, BPA up-regulated the expression of ERCC5 encoding a DNA endonuclease for nucleotide-excision repair. Further electrochemical experiment showed that BPA induced significant DNA damage in ER-positive MCF-7 cells but not in ER-negative HEK293 cells. Collectively, our study revealed that ER-negative HEK293 cells employed mechanisms in response to BPA exposure different from ER-positive cells.

  20. COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis.

    Science.gov (United States)

    Fang, Jingye; Liu, Ming; Zhang, Xuebao; Sakamoto, Takeshi; Taatjes, Douglas J; Jena, Bhanu P; Sun, Fei; Woods, James; Bryson, Tim; Kowluru, Anjaneyulu; Zhang, Kezhong; Chen, Xuequn

    2015-08-01

    Pancreatic β-cells possess a highly active protein synthetic and export machinery in the endoplasmic reticulum (ER) to accommodate the massive production of proinsulin. ER homeostasis is vital for β-cell functions and is maintained by the delicate balance between protein synthesis, folding, export, and degradation. Disruption of ER homeostasis by diabetes-causing factors leads to β-cell death. Among the 4 components to maintain ER homeostasis in β-cells, the role of ER export in insulin biogenesis is the least understood. To address this knowledge gap, the present study investigated the molecular mechanism of proinsulin ER export in MIN6 cells and primary islets. Two inhibitory mutants of the secretion-associated RAS-related protein (Sar)1 small GTPase, known to specifically block coat protein complex II (COPII)-dependent ER export, were overexpressed in β-cells using recombinant adenoviruses. Results from this approach, as well as small interfering RNA-mediated Sar1 knockdown, demonstrated that defective Sar1 function blocked proinsulin ER export and abolished its conversion to mature insulin in MIN6 cells, isolated mouse, and human islets. It is further revealed, using an in vitro vesicle formation assay, that proinsulin was packaged into COPII vesicles in a GTP- and Sar1-dependent manner. Blockage of COPII-dependent ER exit by Sar1 mutants strongly induced ER morphology change, ER stress response, and β-cell apoptosis. These responses were mediated by the PKR (double-stranded RNA-dependent kinase)-like ER kinase (PERK)/eukaryotic translation initiation factor 2α (p-eIF2α) and inositol-requiring protein 1 (IRE1)/x-box binding protein 1 (Xbp1) pathways but not via activating transcription factor 6 (ATF6). Collectively, results from the study demonstrate that COPII-dependent ER export plays a vital role in insulin biogenesis, ER homeostasis, and β-cell survival.

  1. Incredibly close-A newly identified peroxisome-ER contact site in humans.

    Science.gov (United States)

    Schuldiner, Maya; Zalckvar, Einat

    2017-02-01

    Peroxisomes are tiny organelles that control important and diverse metabolic processes via their interplay with other organelles, including the endoplasmic reticulum (ER). In this issue, Costello et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607055) and Hua et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608128) identify a peroxisome-ER contact site in human cells held together by a tethering complex of VAPA/B (vesicle-associated membrane protein-associated proteins A/B) and ACBD5 (acyl Co-A binding protein 5).

  2. Modeling of Yb3+-sensitized Er3+-doped silica waveguide amplifiers

    DEFF Research Database (Denmark)

    Lester, Christian; Bjarklev, Anders Overgaard; Rasmussen, Thomas

    1995-01-01

    A model for Yb3+-sensitized Er3+-doped silica waveguide amplifiers is described and numerically investigated in the small-signal regime. The amplified spontaneous emission in the ytterbium-band and the quenching process between excited erbium ions are included in the model. For pump wavelengths...... between 860 and 995 nm, the amplified spontaneous emission in the ytterbium-band is found to reduce both the gain and the optimum length of the amplifier significantly. The achievable gain of the Yb3+-sensitized amplifier is found to be higher than in an Er3+-doped silica waveguide without Yb 3+ (18 d...

  3. Kosmotropic anions promote conversion of recombinant prion protein into a PrPSc-like misfolded form.

    Directory of Open Access Journals (Sweden)

    Rodrigo Diaz-Espinoza

    Full Text Available Prions are self-propagating proteins involved in transmissible spongiform encephalopaties in mammals. An aberrant conformation with amyloid-like features of a cell surface protein, termed prion protein (PrP, is thought to be the essential component of the infectious particle, though accessory co-factor molecules such as lipids and nucleotides may be involved. The cellular co-factors and environmental conditions implicated in PrP misfolding are not completely understood. To address this issue, several studies have been done inducing misfolding of recombinant PrP (recPrP into classical amyloid structures using partially denaturing conditions. In this work, we report that misfolding of recPrP into PrP(Sc-like aggregates can be induced by simply incubating the protein in the presence of kosmotropic salts at concentrations that are known to retain or increase the stability of the protein. We used a simple experimental reaction (protein, buffer and salts submitted to agitation/incubation cycles at physiological temperature and pH. The formation of protease resistant-recPrP was time and salt-concentration dependent and required the presence of kosmotropic anions such as F(- or SO(4(-2. The molecular weights of the protease resistant recPrP fragments are reminiscent of those found in degradation assays of bona fide PrP(Sc. The aggregates also exhibited PrP(Sc-like ultrastructural features including rod-shape morphology under electron microscope, high beta-sheet content and thioflavin-T positive signal. The formation of recPrP aggregates with PrP(Sc biochemical features under conditions closer to physiological in the absence of organic co-factor molecules provides a simple setup that may prove helpful to understand the molecular mechanism of PrP misfolding.

  4. An evolutionary test of the isoform switching hypothesis of functional progesterone withdrawal for parturition: humans have a weaker repressive effect of PR-A than mice.

    Science.gov (United States)

    Wagner, Günter P; Tong, Yingchun; Emera, Deena; Romero, Roberto

    2012-03-27

    A decrease in maternal serum progesterone (P4) concentrations precedes the onset of labor in most placental mammals. Humans differ by maintaining high levels of P4 throughout birth. Parturition in humans probably includes mechanisms that undercut the pregnancy sustaining function of P4. One attractive hypothesis is the isoform switching hypothesis (ISH). ISH is supported by in vitro evidence that progesterone receptor isoform A (PR-A) inhibits PR-B and that the PR-A/PR-B ratio increases towards term. Here, we test the hypothesis that isoform switching is an adaptation to high levels of P4 at term, predicting that, in humans, PR-A mediated repression of PR-B is stronger than in mouse. We use reporter assays with human and mouse PRs to detect species differences in the repressive effects of PR-A. We found that human PR-B is less sensitive to repression by human PR-A than mouse PR-B, contrary to our prediction. The difference between human and mouse PR-B sensitivity is most pronounced at PR-A/PR-B ratios typical for the preterm myometrium. Our results are inconsistent with the ISH. We speculate that, instead, the lower sensitivity of human PR-B to PR-A may be relevant for the maintenance of pregnancy at high progesterone levels and increasing PR-A concentrations towards term.

  5. Selective photothermal ablation of tissue with a fiber-delivered Er:YAG laser

    Science.gov (United States)

    Pierce, Mark C.; Dickinson, Mark R.; Devlin, Hugh

    1999-06-01

    The feasibility of using laser-induced photoemission signals to distinguish between hard and soft biological tissues during photothermal ablation with a pulsed Er:YAG laser has been investigated. Time-resolved emission spectroscopy indicated a threshold fluence of approximately 35 J/cm2 to regularly initiate photoemission from dental enamel, while no emission was detected from porcine muscle tissue with incident laser fluences of up to approximately 140 J/cm2. The delay time of an emission signal with respect to the incident, ablative Er:YAG laser pulse was found to decrease from approximately 150 microseconds near the emission threshold fluence to approximately 60 microseconds at the highest fluence level used. Optical multichannel analyzer spectroscopy of Er:YAG irradiated enamel demonstrated that photoemissions typically consisted of a broad, continuous background in the visible region, with superimposed peaks arising from the presence of elements including calcium, characteristic of plasma emission either from the sample surface or emission plume.

  6. Investigation of the touch sensitivity of ER fluid based tactile display

    Science.gov (United States)

    Liu, Yanju; Davidson, Rob; Taylor, Paul

    2005-05-01

    A tactile display is programmable device whose controlled surface is intended to be investigated by human touch. It has a great number of potential applications in the field of virtual reality and elsewhere. In this research, a 5x5 touch sensitive tactile display array including electrorheological (ER) fluid has been developed and investigated. Experimental results show that the sensed surface information could be controlled effectively by adjusting the voltage activation pattern imposed on the tactels. In the meantime, it is possible to sense the touching force normal to the display"s surface by monitoring the change of current passing through the ER fluid. These encouraging results are helpful for constructing a new type of tactile display based on ER fluid which can act as both sensor and actuator at the same time.

  7. Er etnisk identitet kun for minoriteter?

    DEFF Research Database (Denmark)

    Steensen, Jette Johanne Elisabeth

    2010-01-01

    Kapitlet bygger på indsigter fra kritisk multikulturel pædagogik, som anvender racismebegrebet i bredere betydning end vi sædvanligvis forstår det i Danmark og spørger om ikke etniske minoriteter i Danmark kan siges at blive udsat for racisme. Kapitlet introducerer vigtige pointer fra Beverely Ta...... Tatums bog: " Why are all the black kids sitting together in the cafeteria? Tatum definerer begrebet racisme som et " system of advantage based on race" og pointen hermed er, at det ikke bare drejer sig om individuelle fordomme, men om strukturel ulighed....

  8. Atomic transition probabilities of Er i

    Science.gov (United States)

    Lawler, J. E.; Wyart, J.-F.; Den Hartog, E. A.

    2010-12-01

    Atomic transition probabilities for 562 lines of the first spectrum of erbium (Er i) are reported. These data are from new branching fraction measurements on Fourier transform spectra normalized with previously reported radiative lifetimes from time-resolved laser-induced fluorescence measurements (Den Hartog et al 2010 J. Phys. B: At. Mol. Opt. Phys. 43 155004). The wavelength range of the data set is from 298 to 1981 nm. In this work we explore the utility of parametric fits based on the Cowan code in assessing branching fraction errors due to lines connecting to unobserved lower levels.

  9. Hvad er kildekritik?

    DEFF Research Database (Denmark)

    Olden-Jørgensen, Sebastian

    2009-01-01

    Hvad er Kildekritik? I stedet for at forstå kildekritik som et stringent system, grundlagt af Leopold von Ranke og i Danmark kanoniseret af Kristian Erslev, kunne man med større historiografisk ret og faglig frugtbarhed opfatte kildekritikken som en faglig tradition med tre lag afsat (sedimenteret......) gennem de seneste femhundrede år: den filologiske kritik, den historistiske kritik, den poppersk-hermeneutiske kritik. Alt efter den konkrete undersøgelses tilsnit vil forskellige dele af denne tradition komme i spil....

  10. Electric-dipole transitions in 165Er

    Institute of Scientific and Technical Information of China (English)

    WANG Shi-Tao; ZHOU Xiao-Hong; ZHANG Yu-Hu; ZHENG Yong; LIU Min-Liang; MA Fei; HU Jun; CHEN Liang; ZHANG Xin; ZHANG Ning-Tao; ZHU Li-Hua; WU Xiao-Guang; LI Guang-Sheng

    2009-01-01

    High-spin states of 165Er were studied using the 160Gd(9Be, 4n)reaction at beam energies of 42 and 45 MeV. The previously known bands based on the γ5/2-[523] and γ5/2+ [642] configurations have been extended to high-spin states. Electric-dipole transitions linking these two opposite parity bands were observed. Relatively large B(E1) values have been extracted experimentally and were attributed to octupole softness.

  11. Pressure response of electrorheological suspension in a model ER damper; ER damper model ni okeru bunsanke ER ryutai no atsuryoku oto

    Energy Technology Data Exchange (ETDEWEB)

    Nakano, M.; Yonekawa, T. [Yamagata University, Yamagata (Japan). Faculty of Engineering

    1995-01-25

    This paper reports the examination result of the pressure response of an electrorheological suspension fluid (obtained when the particles of a strong acid ion-exchange resin are dispersed on silicon oil and whose rheological characteristics vary with the action in the external electric field) in an electrorheological (ER) damper model (experimental equipment consisting of an ER valve with plane parallel electrode and a piston cylinder). A rectangular wave voltage is applied to the ER valve to obtain the pressure fall components based on the steady ER effect of an ER fluid flowing between the plane parallel electrodes. The intensity of the electric field and the dependence on the flow velocity were formulated by an approximate function. The flow velocity dependency of this ER effect does not coincide with the theoretical analysis result based on a Bingham fluid model. The pressure in a cylinder presents the transient response of a first-order lag to the rectangular wave voltage input to the ER valve. The time constant value in this case can be explained by considering the compressibility of the residual air in the ER fluid. 11 refs., 11 figs.

  12. Préparation et caractérisation d'une série de cyclohexaphosphates de terres rares: Ln2P 6O 18 · 10H 2O

    Science.gov (United States)

    Elmokhtar, Ould Sidi Mohamed; Rzaigui, Mohamed

    1995-10-01

    Six new cyclohexaphosphates with the general formula Ln2 P 6O 18 · 10H 2O with Ln = La, Ce, Pr, Sm, Er, and Yb are reported. They belong to two different structure types. The first type, common to three compounds, corresponds to Ln = La, Ce, and Pr, with an orthorhombic unit cell, Z = 2, and space group P2 12 12. The second type, common to three compounds also, corresponds to Ln = Sm, Er, and Yb, with a monoclinic unit cell, Z = 4, and space group P2 1/ a. Synthesis and characterization by X-ray diffraction, IR absorption, and TA are given.

  13. PrEP implementation in the Asia-Pacific region: opportunities, implementation and barriers

    Directory of Open Access Journals (Sweden)

    Iryna Zablotska

    2016-10-01

    Full Text Available Introduction: HIV epidemics in the Asia-Pacific region are concentrated among men who have sex with men (MSM and other key populations. Pre-exposure prophylaxis (PrEP is an effective HIV prevention intervention and could be a potential game changer in the region. We discuss the progress towards PrEP implementation in the Asia-Pacific region, including opportunities and barriers. Discussion: Awareness about PrEP in the Asia-Pacific is still low and so are its levels of use. A high proportion of MSM who are aware of PrEP are willing to use it. Key PrEP implementation barriers include poor knowledge about PrEP, limited access to PrEP, weak or non-existent HIV prevention programmes for MSM and other key populations, high cost of PrEP, stigma and discrimination against key populations and restrictive laws in some countries. Only several clinical trials, demonstration projects and a few larger-scale implementation studies have been implemented so far in Thailand and Australia. However, novel approaches to PrEP implementation have emerged: researcher-, facility- and community-led models of care, with PrEP services for fee and for free. The WHO consolidated guidelines on HIV testing, treatment and prevention call for an expanded access to PrEP worldwide and have provided guidance on PrEP implementation in the region. Some countries like Australia have released national PrEP guidelines. There are growing community leadership and consultation processes to initiate PrEP implementation in Asia and the Pacific. Conclusions: Countries of the Asia-Pacific region will benefit from adding PrEP to their HIV prevention packages, but for many this is a critical step that requires resourcing. Having an impact on the HIV epidemic requires investment. The next years should see the region transitioning from limited PrEP implementation projects to growing access to PrEP and expansion of HIV prevention programmes.

  14. PrEP implementation in the Asia-Pacific region: opportunities, implementation and barriers

    Science.gov (United States)

    Zablotska, Iryna; Grulich, Andrew E; Phanuphak, Nittaya; Anand, Tarandeep; Janyam, Surang; Poonkasetwattana, Midnight; Baggaley, Rachel; van Griensven, Frits; Lo, Ying-Ru

    2016-01-01

    Introduction HIV epidemics in the Asia-Pacific region are concentrated among men who have sex with men (MSM) and other key populations. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention intervention and could be a potential game changer in the region. We discuss the progress towards PrEP implementation in the Asia-Pacific region, including opportunities and barriers. Discussion Awareness about PrEP in the Asia-Pacific is still low and so are its levels of use. A high proportion of MSM who are aware of PrEP are willing to use it. Key PrEP implementation barriers include poor knowledge about PrEP, limited access to PrEP, weak or non-existent HIV prevention programmes for MSM and other key populations, high cost of PrEP, stigma and discrimination against key populations and restrictive laws in some countries. Only several clinical trials, demonstration projects and a few larger-scale implementation studies have been implemented so far in Thailand and Australia. However, novel approaches to PrEP implementation have emerged: researcher-, facility- and community-led models of care, with PrEP services for fee and for free. The WHO consolidated guidelines on HIV testing, treatment and prevention call for an expanded access to PrEP worldwide and have provided guidance on PrEP implementation in the region. Some countries like Australia have released national PrEP guidelines. There are growing community leadership and consultation processes to initiate PrEP implementation in Asia and the Pacific. Conclusions Countries of the Asia-Pacific region will benefit from adding PrEP to their HIV prevention packages, but for many this is a critical step that requires resourcing. Having an impact on the HIV epidemic requires investment. The next years should see the region transitioning from limited PrEP implementation projects to growing access to PrEP and expansion of HIV prevention programmes. PMID:27760688

  15. Nuclear structure and high-spin states of 137Pr

    Science.gov (United States)

    Dragulescu, E.; Ivascu, M.; Petrache, C.; Popescu, D.; Semenescu, G.; Gurgu, I.; Ionescu-Bujor, M.; Iordachescu, A.; Pascovici, G.; Meyer, R. A.; Lopac, V.; Brant, S.; Paar, V.; Vorkapić, D.; Vretenar, D.

    1992-10-01

    Levels in 137Pr were populated in the 126Te( 14N, 3n) and 122Sn( 19F, 4n) reactions and the subsequent radiation was studied using in-beam γ-ray spectroscopy methods including γ-ray excitation-function, angular-distribution, γγ( t) coincidence and γ( t) measurements. A level scheme with new states up to spin {35}/{2} belonging to 137Pr is given. The lifetime of the {11}/{21} state at 563.4 keV has been determined as T {1}/{2} = 2.66±0.07 μ s. The calculation of low-lying levels in 137Pr performed in IBFM has been compared to experimental data.

  16. Persistent ER stress induces the spliced leader RNA silencing pathway (SLS, leading to programmed cell death in Trypanosoma brucei.

    Directory of Open Access Journals (Sweden)

    Hanoch Goldshmidt

    2010-01-01

    Full Text Available Trypanosomes are parasites that cycle between the insect host (procyclic form and mammalian host (bloodstream form. These parasites lack conventional transcription regulation, including factors that induce the unfolded protein response (UPR. However, they possess a stress response mechanism, the spliced leader RNA silencing (SLS pathway. SLS elicits shut-off of spliced leader RNA (SL RNA transcription by perturbing the binding of the transcription factor tSNAP42 to its cognate promoter, thus eliminating trans-splicing of all mRNAs. Induction of endoplasmic reticulum (ER stress in procyclic trypanosomes elicits changes in the transcriptome similar to those induced by conventional UPR found in other eukaryotes. The mechanism of up-regulation under ER stress is dependent on differential stabilization of mRNAs. The transcriptome changes are accompanied by ER dilation and elevation in the ER chaperone, BiP. Prolonged ER stress induces SLS pathway. RNAi silencing of SEC63, a factor that participates in protein translocation across the ER membrane, or SEC61, the translocation channel, also induces SLS. Silencing of these genes or prolonged ER stress led to programmed cell death (PCD, evident by exposure of phosphatidyl serine, DNA laddering, increase in reactive oxygen species (ROS production, increase in cytoplasmic Ca(2+, and decrease in mitochondrial membrane potential, as well as typical morphological changes observed by transmission electron microscopy (TEM. ER stress response is also induced in the bloodstream form and if the stress persists it leads to SLS. We propose that prolonged ER stress induces SLS, which serves as a unique death pathway, replacing the conventional caspase-mediated PCD observed in higher eukaryotes.

  17. How to Make Big Improvements in the Small PR Shop. Revised.

    Science.gov (United States)

    Moore, R. Keith, Comp.; Hunt, Susan, Ed.

    This guide for small public relations (PR) offices at colleges and universities includes sample job descriptions, information on PR duties and priorities, sample policy statements and operating guidelines, sample publicity materials, questionnaires, and internal forms for organization. Twenty-six tips on time management are provided in an article…

  18. Den der ser, er den, der ses

    DEFF Research Database (Denmark)

    Bjerrum, Troels

    2010-01-01

    at foretage sig nødvendige samfundsmæssige valg. På grund af nederlag i hjem, skole, uddannelse og erhverv søger unge fællesskaber i ligestillede miljøer svarende til egen negative forventningspraksis. Den unge praktiserer en vanedannende negativ livsførelse, som eskalerer til yderligere socialt forfald. Unge......, der har levet i kriminalitet, misbrug og medmisbrug i lang tid, vil ikke være i stand til at realisere sig positivt pga. en personlig indgroet diskvalificerende forestilling. Afhandlingen forklarer, hvorledes negative oplevelser forbliver spændinger i menneskers krop. Teorier af Maurice Merleau...... begreb for personlig sammenhæng af kropslig tilstedeværelse og erkendelse. Bevidst kan udsatte unge forhindre vanedannende impulsstyring og lære sig selv at rette intension ud mod verden frem for aggression. Grundlæggende er det afhandlingens tese, at gentagende negative oplevelser lægger mønstret til...

  19. Multiple integrerede præstationsmålingssystemer: Videnregnskab og balanced scorecard i en software virksomhed?

    DEFF Research Database (Denmark)

    Bukh, Per Nikolaj; Johansen, Mette Rosenkrands; Mouritsen, Jan

    2002-01-01

    to modellers forskelle og komplementariteter på baggrund af en analyse af deres anvendelse i en mellemstor dansk softwarevirksomhed, Systematic Software Engineering. Denne virksomhed har i de sidste to år publiceret videnregnskaber og har for nylig implementeret et balanced scorecard. Videnregnskabet......Både videnregnskaber og balanced scorecard er integrerede præstationsmålingssystemer relateret til virksomhedens strategi, og de udvider begge rapportering til ud over finansielle nøgletal at inkludere ikke-finansielle nøgletal for kunder, processer og medarbejdere. Denne artikel diskuterer de...

  20. TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion

    Directory of Open Access Journals (Sweden)

    Janine McCaughey

    2016-05-01

    Full Text Available Collagen is the most abundant protein in the animal kingdom. It is of fundamental importance during development for cell differentiation and tissue morphogenesis as well as in pathological processes such as fibrosis and cancer cell migration. However, our understanding of the mechanisms of procollagen secretion remains limited. Here, we show that TFG organizes transitional ER (tER and ER exit sites (ERESs into larger structures. Depletion of TFG results in dispersion of tER elements that remain associated with individual ER-Golgi intermediate compartments (ERGICs as largely functional ERESs. We show that TFG is not required for the transport and packaging of small soluble cargoes but is necessary for the export of procollagen from the ER. Our work therefore suggests a key relationship between the structure and function of ERESs and a central role for TFG in optimizing COPII assembly for procollagen export.

  1. Ultrahigh Spin Structures in 157,158,159Er

    Institute of Scientific and Technical Information of China (English)

    MA Hai-Liang; DONG Bao-Guo; YAN Yu-Liang

    2008-01-01

    Rotational structures at ultrahigh spin in 157'158'159Er have been investigated with the configuration-dependent cranked Nilsson-Strutinsky approach. Configurations of observed bands are assigned and the corresponding deformations are given theoretically. The calculations suggest that one of ultrahigh spin bands in 158Er is triaxial highly deformed and the other is normal-deformed, while both ultrahigh spin bands in 157Er are suggested to be triaxial highly deformed. The possible ultrahigh spin bands in l59Er are predicted to be triaxial highly deformed and have shape coexistence in the same configuration. The configurations with two neutron holes in the Nosc=4 orbitals and two neutron holes in the h11/2 orbitals in 159Er are favoured for ultrahigh spin states but unfavoured for band termination, which is similar to ultrahigh spin bands in 157,158Er.

  2. Co- and post-translational protein folding in the ER

    DEFF Research Database (Denmark)

    Ellgaard, Lars; McCaul, Nicholas; Chatsisvili, Anna

    2016-01-01

    and the variety of ER-specific protein modifications. Here, we review chaperone-assisted co- and post-translational folding and assembly in the ER and underline the influence of protein modifications on these processes. We emphasize how method development has helped advance the field by allowing researchers......The biophysical rules that govern folding of small, single-domain proteins in dilute solutions are now quite well understood. The mechanisms underlying co-translational folding of multidomain and membrane-spanning proteins in complex cellular environments are often less clear. The endoplasmic...... reticulum (ER) produces a plethora of membrane and secretory proteins, which must fold and assemble correctly before ER exit - if these processes fail, misfolded species accumulate in the ER or are degraded. The ER differs from other cellular organelles in terms of the physicochemical environment...

  3. Fiskere og fangeres indkomster i bygder er alarmerende lave

    DEFF Research Database (Denmark)

    Rasmussen, Rasmus Ole; Petersen, Carsten

    2006-01-01

    I et internationalt perspektiv er indkomsterne i Grønland stadig meget ulige fordelt – mere ulige end i USA og væsentlig mere ulige end i de øvrige nordiske lande. Samtidig er der nogle markante erhvervsmæssige og regionale forskelle, hvor indtægterne er alarmerende lave, ikke mindst for gruppen ...... fangere og fiskere i bygderne Udgivelsesdato: 23 februar...

  4. Que nous dit la Préhistoire des conditions de l'invention ?

    OpenAIRE

    De Beaune, Sophie A.

    2012-01-01

    Actes du Colloque Eurêka 2. Inventer, créer. Le rôle de la technique dans la création, Université de Haute-Bretagne Rennes 2, 25-26 mai 2009.; La Préhistoire constitue un laboratoire privilégié pour étudier les processus d'invention dans la mesure où elle suppose que les inventions primordiales sont nées à partir d'une sorte de tabula rasa. Ainsi, faire un détour par la préhistoire peut nous aider à mieux comprendre les conditions nécessaires à l'invention.

  5. Quelle préposition ?

    CERN Document Server

    Grevisse, Maurice

    1996-01-01

    Pour bien parler ou bien écrire, il faut avant tout posséder un bon vocabulaire, puis savoir bien remuer les mots, leur faire exprimer quelque chose et agencer adroitement les propositions. Il faut aussi - et cela n'est pas négligeable - amener congrûment les divers compléments des noms, des adjectifs ou des verbes ; quand ces compléments sont de construction indirecte, c'est-à-dire quand ils doivent être introduits par une préposition, on hésite parfois sur la bonne manière de les accrocher. Ne pas négliger le bon choix! Cela ne crée pas le style, sans doute, mais peut, pour une part, témoigner de sa bonne qualité.

  6. Altered methylation and expression of ER-associated degradation factors in long-term alcohol and constitutive ER stress-induced murine hepatic tumors

    Directory of Open Access Journals (Sweden)

    Hui eHan

    2013-10-01

    Full Text Available Mortality from liver cancer in humans is increasingly attributable to heavy or long-term alcohol consumption. The mechanisms by which alcohol exerts its carcinogenic effect are not well understood. In this study, the role of alcohol-induced endoplasmic reticulum (ER stress response in liver cancer development was investigated using an animal model with a liver knockout of the chaperone BiP and under constitutive hepatic ER stress. Long-term alcohol and high fat diet (HFD feeding resulted in higher levels of serum alanine aminotransferase (ALT, impaired ER stress response, and higher incidence of liver tumor in older (aged 16 months knockout females than in either middle-aged (6 months knockouts or older (aged 16 months wild type females. In the older knockout females, stronger effects of the alcohol on methylation of CpG islands at promoter regions of genes involved in the ER associated degradation (ERAD were also detected. Altered expression of ERAD factors including derlin 3, Creld2 (cysteine-rich with EGF-like domains 2, Herpud1 (ubiquitin-like domain member, Wfs1 (wolfram syndrome gene, and Yod1 (deubiquinating enzyme 1 was co-present with decreased proteasome activities, increased estrogen receptor alpha variant (ERa36, and enhanced phosphorylations of ERK1/2 (extracellular signal-regulated protein kinases 1 and 2 and STAT3 (the signal transducers and activators of transcription in the older knockout female fed alcohol. Our results suggest that long-term alcohol consumption and ageing may promote liver tumorigenesis in females through interfering with DNA methylation and expression of genes involved in the ER associated degradation.

  7. Parimad suhtekorraldusteod konkursil Baltic PR Awards

    Index Scriptorium Estoniae

    2012-01-01

    Balti riikide suhtekorraldusliidud koostöös Rahvusvahelise Avalike Suhete Assotsiatsiooniga (IPRA) korraldavad 2001. aastast iga aasta kommunikatsioonijuhtimisalast auhinnakonkurssi Baltic PR Awards

  8. Præstationsledelse - potentiale og faldgruber

    DEFF Research Database (Denmark)

    Elmholdt, Claus Westergård

    2015-01-01

    Performance management-maskinen buldrer derudaf i danske virksomheder, men hvornår skal KPI’er, bonusmål og resultatmålinger give anledning til begejstring – og hvornår bekymring? Her er et bud på, hvad du skal være opmærksom på som leder.......Performance management-maskinen buldrer derudaf i danske virksomheder, men hvornår skal KPI’er, bonusmål og resultatmålinger give anledning til begejstring – og hvornår bekymring? Her er et bud på, hvad du skal være opmærksom på som leder....

  9. Er Web 2.0 klar til mainstream?

    DEFF Research Database (Denmark)

    Ivang, Reimer

    2009-01-01

    BLOG: Spørgsmålene der relateres til Web 2.0 er mange. Men en af de mest signifikante er om netop din virksomhed skal anvende Web 2.0 teknologier? Hvad kan I få ud af det?......BLOG: Spørgsmålene der relateres til Web 2.0 er mange. Men en af de mest signifikante er om netop din virksomhed skal anvende Web 2.0 teknologier? Hvad kan I få ud af det?...

  10. Her er CBS’ nye eksamensklinik på Solbjergvej

    DEFF Research Database (Denmark)

    Holdt Christensen, Peter

    2013-01-01

    CBS’ nyindrettede eksamenslokaler på Solbjergvej er stadig lidt ’work in progress’. Der er nogle uhensigtsmæssigheder, der skal justeres på plads, men frigørelsen af grupperum til de studerende på resten af CBS var en mærkesag.......CBS’ nyindrettede eksamenslokaler på Solbjergvej er stadig lidt ’work in progress’. Der er nogle uhensigtsmæssigheder, der skal justeres på plads, men frigørelsen af grupperum til de studerende på resten af CBS var en mærkesag....

  11. Evaluating the potential bioactivity of a novel compound ER1626.

    Directory of Open Access Journals (Sweden)

    Lijun Wang

    Full Text Available BACKGROUND: ER1626, a novel compound, is a derivate of indeno-isoquinoline ketone. This study was designed to evaluate the biological activity and potential anti-tumor mechanism of ER1626. METHOD: MTT assay, scratch assay and flow cytometry were used to determine cell proliferation, cell migration and cell cycle distribution as well as cell apoptosis on human breast cancer MCF-7 cells and endometrial cancer Ishikawa cells. We also explored the antiangiogenic effect of ER1626 on HUVEC cells and chicken embryos. The expression of estrogen receptor protein was investigated with western-blot analysis. RESULTS: ER1626 down-regulated the expression of estrogen receptor α protein and up-regulated β protein in MCF-7 and Ishikawa cells. The value of IC50 of ER1626 on MCF-7 and Ishikawa cells were respectively 8.52 and 3.08 µmol/L. Meanwhile, ER1626 decreased VEGF secretion of MCF-7 and Ishikawa cells, disturbed the formation of VEGF-stimulated tubular structure in HUVEC cells, and inhibited the angiogenesis on the chicken chorioallantoic membrane. Scratch assay revealed that ER1626 suppressed the migration of MCF-7, Ishikawa and HUVEC cells. In addition to induction tumor cell apoptosis, ER1626 arrested cell cycle in G1/G0 phase in MCF-7 cells and G2/M phase in Ishikawa cells. CONCLUSION: In conclusion, our results demonstrated that ER1626 has favorable bioactivities to be a potential candidate against breast cancer and angiogenesis.

  12. Er Web 2.0 klar til mainstream?

    DEFF Research Database (Denmark)

    Ivang, Reimer

    2009-01-01

    BLOG: Spørgsmålene der relateres til Web 2.0 er mange. Men en af de mest signifikante er om netop din virksomhed skal anvende Web 2.0 teknologier? Hvad kan I få ud af det?......BLOG: Spørgsmålene der relateres til Web 2.0 er mange. Men en af de mest signifikante er om netop din virksomhed skal anvende Web 2.0 teknologier? Hvad kan I få ud af det?...

  13. ESO PR Highlights in 2007

    Science.gov (United States)

    2008-01-01

    Another great year went by for ESO, the European Organisation for Astronomical Research in the Southern Hemisphere. From 1 January 2007, with the official joining of the Czech Republic, ESO has 13 member states, and since September, ESO has a new Director General, Tim de Zeeuw (ESO 03/07 and 38/07). Many scientific discoveries were made possible with ESO's telescopes. Arguably, the most important is the discovery of the first Earth-like planet in the habitable zone of a low-mass red dwarf (ESO 22/07). If there is water on this planet, then it should be liquid! ESO PR Highlights 2007 This is a clickable map. These are only some of the press releases issued by ESO in 2007. For a full listing, please go to ESO 2007 page. In our own Solar System also, astronomers made stunning breakthroughs with ESO's telescopes, observing the effect of the light from the Sun on an asteroid's rotation (ESO 11/07), describing in unprecedented detail the double asteroid Antiope (ESO 18/07), peering at the rings of Uranus (ESO 37/07), discovering a warm south pole on Neptune (ESO 41/07), showing a widespread and persistent morning drizzle of methane over the western foothills of Titan's major continent (ESO 47/07), and studying in the greatest details the wonderful Comet McNaught (ESO 05/07 and 07/07). In the study of objects slightly more massive than planets, the VLT found that brown dwarfs form in a similar manner to normal stars (ESO 24/07). The VLT made it also possible to measure the age of a fossil star that was clearly born at the dawn of time (ESO 23/07). Other discoveries included reconstructing the site of a flare on a solar-like star (ESO 53/07), catching a star smoking (ESO 34/07), revealing a reservoir of dust around an elderly star (ESO 43/07), uncovering a flat, nearly edge-on disc of silicates in the heart of the magnificent Ant Nebula (ESO 42/07), finding material around a star before it exploded (ESO 31/07), fingerprinting the Milky Way (ESO 15/07), revealing a rich

  14. ERS statement on the multidisciplinary respiratory management of ataxia telangiectasia.

    Science.gov (United States)

    Bhatt, Jayesh M; Bush, Andrew; van Gerven, Marjo; Nissenkorn, Andreea; Renke, Michael; Yarlett, Lian; Taylor, Malcolm; Tonia, Thomy; Warris, Adilia; Zielen, Stefan; Zinna, Shairbanu; Merkus, Peter J F M

    2015-12-01

    Ataxia telangiectasia (A-T) is a rare, progressive, multisystem disease that has a large number of complex and diverse manifestations which vary with age. Patients with A-T die prematurely with the leading causes of death being respiratory diseases and cancer. Respiratory manifestations include immune dysfunction leading to recurrent upper and lower respiratory infections; aspiration resulting from dysfunctional swallowing due to neurodegenerative deficits; inefficient cough; and interstitial lung disease/pulmonary fibrosis. Malnutrition is a significant comorbidity. The increased radiosensitivity and increased risk of cancer should be borne in mind when requesting radiological investigations. Aggressive proactive monitoring and treatment of these various aspects of lung disease under multidisciplinary expertise in the experience of national multidisciplinary clinics internationally forms the basis of this statement on the management of lung disease in A-T. Neurological management is outwith the scope of this document. Copyright ©ERS 2015.

  15. Impact of estrogen receptor (ER) and human epidermal growth factor receptor-2 (HER2) co-expression on breast cancer disease characteristics: implications for tumor biology and research.

    Science.gov (United States)

    Alqaisi, Abeer; Chen, Li; Romond, Edward; Chambers, Mara; Stevens, Mark; Pasley, Grace; Awasthi, Mukta; Massarweh, Suleiman

    2014-11-01

    ER and HER2 are critical drivers of breast cancer biology and can interact when co-expressed, but less data describe the impact of ER/HER2 co-expression on clinical disease characteristics. We studied the impact of ER and HER2 (co)-expression in a cohort of 1,187 patients with invasive breast cancer and compared disease characteristics among different groups according to ER and HER2 status. Age, tumor size, grade, nodal status, TNM stage, and metastatic sites were compared and significance determined using the appropriate t tests. All p values were two-tailed. Compared to ER-negative/HER2-negative disease as the control group, ER expression was associated with older age, smaller tumors, lower grade, earlier TNM stage, and increased bone involvement in de novo metastasis, while HER2 had no significant impact on these characteristics. ER and HER2 co-expression was associated with lower grade and higher bone involvement in de novo metastasis, reflecting a retained impact for ER. HER2 impact on ER-positive disease was reflected by younger age, higher grade and TNM stage, and increased frequency of visceral involvement in de novo metastasis. Within the ER-positive/HER2-positive group, triple positive breast cancer (ER+/PgR+/HER2+) was associated with younger age compared to ER+/PgR-/HER2+ disease (mean age of 50.8 vs. 56 years, p = 0.0226). PgR was also associated with younger age in ER+/HER2- disease with a mean age of 57.6 years in ER+/PgR+/HER2- disease vs. 63.4 years in ER+/PgR-/HER2- disease (p impact on breast cancer characteristics, including a retained impact when co-expressed with HER2. Similarly, HER2 dramatically modulates ER-positive breast cancer making it more aggressive. PgR association with young age may be related to hormonal levels of the premenopausal state, with HER2 providing an earlier growth advantage in triple positive disease, suggesting a specific dependence for this subset on high estrogen levels.

  16. Præstationsledelse i en krisetid

    DEFF Research Database (Denmark)

    Elmholdt, Claus Westergård; Hoffmann Birk, Rasmus; Børgesen, Kenneth

    Er hård styring den bedste vej ud af en krise? Og, hvad er konsekvenserne for mellemlederne når topledelsen ruller ud med hård krisestyring? Vi ved at meningsskabende kommunikation står centralt i kriseledelse, men hvordan får man organisationens kommunikationskæder til at hænge sammen fra top til...

  17. Opposing microtubule motors control motility, morphology and cargo segregation during ER-to-Golgi transport

    Directory of Open Access Journals (Sweden)

    Anna K. Brown

    2014-04-01

    Full Text Available We recently demonstrated that dynein and kinesin motors drive multiple aspects of endosomal function in mammalian cells. These functions include driving motility, maintaining morphology (notably through providing longitudinal tension to support vesicle fission, and driving cargo sorting. Microtubule motors drive bidirectional motility during traffic between the endoplasmic reticulum (ER and Golgi. Here, we have examined the role of microtubule motors in transport carrier motility, morphology, and domain organization during ER-to-Golgi transport. We show that, consistent with our findings for endosomal dynamics, microtubule motor function during ER-to-Golgi transport of secretory cargo is required for motility, morphology, and cargo sorting within vesicular tubular carriers en route to the Golgi. Our data are consistent with previous findings that defined roles for dynein-1, kinesin-1 (KIF5B and kinesin-2 in this trafficking step. Our high resolution tracking data identify some intriguing aspects. Depletion of kinesin-1 reduces the number of motile structures seen, which is in line with other findings relating to the role of kinesin-1 in ER export. However, those transport carriers that were produced had a much greater run length suggesting that this motor can act as a brake on anterograde motility. Kinesin-2 depletion did not significantly reduce the number of motile transport carriers but did cause a similar increase in run length. These data suggest that kinesins act as negative regulators of ER-to-Golgi transport. Depletion of dynein not only reduced the number of motile carriers formed but also caused tubulation of carriers similar to that seen for sorting nexin-coated early endosomes. Our data indicated that the previously observed anterograde–retrograde polarity of transport carriers in transit to the Golgi from the ER is maintained by microtubule motor function.

  18. A highly sensitive assay for monitoring the secretory pathway and ER stress.

    Directory of Open Access Journals (Sweden)

    Christian E Badr

    Full Text Available BACKGROUND: The secretory pathway is a critical index of the capacity of cells to incorporate proteins into cellular membranes and secrete proteins into the extracellular space. Importantly it is disrupted in response to stress to the endoplasmic reticulum that can be induced by a variety of factors, including expression of mutant proteins and physiologic stress. Activation of the ER stress response is critical in the etiology of a number of diseases, such as diabetes and neurodegeneration, as well as cancer. We have developed a highly sensitive assay to monitor processing of proteins through the secretory pathway and endoplasmic reticulum (ER stress in real-time based on the naturally secreted Gaussia luciferase (Gluc. METHODOLOGY/PRINCIPLE FINDINGS: An expression cassette for Gluc was delivered to cells, and its secretion was monitored by measuring luciferase activity in the conditioned medium. Gluc secretion was decreased down to 90% when these cells were treated with drugs that interfere with the secretory pathway at different steps. Fusing Gluc to a fluorescent protein allowed quantitation and visualization of the secretory pathway in real-time. Expression of this reporter protein did not itself elicit an ER stress response in cells; however, Gluc proved very sensitive at sensing this type of stress, which is associated with a temporary decrease in processing of proteins through the secretory pathway. The Gluc secretion assay was over 20,000-fold more sensitive as compared to the secreted alkaline phosphatase (SEAP, a well established assay for monitoring of protein processing and ER stress in mammalian cells. CONCLUSIONS/SIGNIFICANCE: The Gluc assay provides a fast, quantitative and sensitive technique to monitor the secretory pathway and ER stress and its compatibility with high throughput screening will allow discovery of drugs for treatment of conditions in which the ER stress is generally induced.

  19. Compartmentalization of ER-Bound Chaperone Confines Protein Deposit Formation to the Aging Yeast Cell.

    Science.gov (United States)

    Saarikangas, Juha; Caudron, Fabrice; Prasad, Rupali; Moreno, David F; Bolognesi, Alessio; Aldea, Martí; Barral, Yves

    2017-03-20

    In order to produce rejuvenated daughters, dividing budding yeast cells confine aging factors, including protein aggregates, to the aging mother cell. The asymmetric inheritance of these protein deposits is mediated by organelle and cytoskeletal attachment and by cell geometry. Yet it remains unclear how deposit formation is restricted to the aging lineage. Here, we show that selective membrane anchoring and the compartmentalization of the endoplasmic reticulum (ER) membrane confine protein deposit formation to aging cells during division. Supporting the idea that the age-dependent deposit forms through coalescence of smaller aggregates, two deposits rapidly merged when placed in the same cell by cell-cell fusion. The deposits localized to the ER membrane, primarily to the nuclear envelope (NE). Strikingly, weakening the diffusion barriers that separate the ER membrane into mother and bud compartments caused premature formation of deposits in the daughter cells. Detachment of the Hsp40 protein Ydj1 from the ER membrane elicited a similar phenotype, suggesting that the diffusion barriers and farnesylated Ydj1 functioned together to confine protein deposit formation to mother cells during division. Accordingly, fluorescence correlation spectroscopy measurements in dividing cells indicated that a slow-diffusing, possibly client-bound Ydj1 fraction was asymmetrically enriched in the mother compartment. This asymmetric distribution depended on Ydj1 farnesylation and intact diffusion barriers. Taking these findings together, we propose that ER-anchored Ydj1 binds deposit precursors and prevents them from spreading into daughter cells during division by subjecting them to the ER diffusion barriers. This ensures that the coalescence of precursors into a single deposit is restricted to the aging lineage.

  20. Regulation of PrP(C) signaling and processing by dimerization.

    Science.gov (United States)

    Roucou, Xavier

    2014-01-01

    The cellular prion protein (PrP(C)) is a glycosylphosphatidylinositol (GPI)-anchored protein present at the cell surface. PrP(C) N-terminal moiety is intrinsically disordered and is able to interact with a variety of ligands. Physiological ligands have neurotrophic activity, whilst others, including protein toxic oligomers, have neurotoxic functions. These two opposite activities involve different interacting partners and result from different PrP(C)-activated signaling pathways. Remarkably, PrP(C) may be inactivated either by physiological endoproteolysis and release of the N-terminal domain, or by ectodomain shedding. Ligand-induced PrP(C) dimerization or enforced dimerization of PrP(C) indicate that PrP(C) dimerization represents an important molecular switch for both intracellular signaling and inactivation by the release of PrP(C) N-terminal domain or shedding. In this review, we summarize evidence that cell surface receptor activity of PrP(C) is finely regulated by dimerization.

  1. Comparación de prácticas inclusivas de docentes de servicios de educación especial y regular en México

    Directory of Open Access Journals (Sweden)

    García Cedillo, Ismael

    2015-09-01

    Full Text Available Las prácticas inclusivas buscan atender a toda la población estudiantil, independientemente de sus características. En el presente artículo se comparan las prácticas docentes de escuelas regulares con apoyo de educación especial (ER-USAER y las escuelas especiales, llamadas Centros de Atención Múltiple (CAM, para conocer dónde se le brinda una atención más inclusiva a la población infantil con discapacidad. Se trabajó con 15 docentes de CAM y 17 de ER-USAER de tres estados de México, a quienes se aplicó la Guía para la Evaluación de las Prácticas Inclusivas en el Aula (GEPIA en su versión de auto-reporte y observación. Los resultados del auto-reporte muestran que las y los docentes de ER-USAER trabajan de manera colaborativa con profesionales de Educación Especial, mientras los de CAM prefieren el trabajo independiente. Los resultados de la observación indican que la planta docente de CAM tiene más prácticas inclusivas que sus pares de ER-USAER, lo cual parece explicarse por sus condiciones de trabajo –reducido número de estudiantes por grupo y cultura escolar- y sus conocimientos sobre discapacidad. Los docentes de ER-USAER no siempre planean considerando a todos los alumnos.

  2. Forskning og uddannelse er en forudsætning for gevinst af Big Data

    DEFF Research Database (Denmark)

    Riis, Mark Bernhard; Rootzén, Helle; Odgaard, Mads H

    2014-01-01

    Vi står lige nu ved begyndelsen til en revolution, der vil forandre den måde, vi lever, arbejder og tænker på. Man taler om en ny Big Data-tidsalder, hvor stort set alt i vores hverdag kan måles og vejes, fordi det kan sættes på digital formel. Big data handler om, at vi systematisk indsamler......, opbevarer, analyserer og fortolker disse enorme mængder af data for at finde sammenhænge, forstå verden bedre og agere bedre i vores hverdag. Hvis vi vil, kan Big Data forbedre vores livskvalitet, skabe vækst og styrke vores demokrati. Men det kræver, at vi er med til at præge fremtidens Big Data-samfund og...

  3. Luis Álvarez Piñer, De la poesía

    OpenAIRE

    Terrasson, Claudie

    2014-01-01

    El libro De la poesía es de un poeta al que podemos calificar de rescatado. Como lo indica el prólogo de Juan Manuel Díaz de Guereñu, Luis Á. Piñer (1910-1999) estuvo sin publicar, o casi, durante medio siglo a raíz de la Guerra Civil y la derrota republicana. El rescate se inició con la publicación en 1990 de su antología En resumen (1927-1988) y el reconocimiento se produjo en 1991 cuando ganó el Premio Nacional de Poesía. De la poesía corresponde a la otra vertiente de la obra de Luis Á. P...

  4. ER@CEBAF: Modeling code developments

    Energy Technology Data Exchange (ETDEWEB)

    Meot, F. [Brookhaven National Lab. (BNL), Upton, NY (United States); Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Roblin, Y. [Brookhaven National Lab. (BNL), Upton, NY (United States); Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2016-04-13

    A proposal for a multiple-pass, high energy, energy-recovery experiment using CEBAF is under preparation in the frame of a JLab-BNL collaboration. In view of beam dynamics investigations regarding this project, in addition to the existing model in use in Elegant a version of CEBAF is developed in the stepwise ray-tracing code Zgoubi, Beyond the ER experiment, it is also planned to use the latter for the study of polarization transport in the presence of synchrotron radiation, down to Hall D line where a 12 GeV polarized beam can be delivered. This Note briefly reports on the preliminary steps, and preliminary outcomes, based on an Elegant to Zgoubi translation.

  5. Final Technical Report for Award # ER64999

    Energy Technology Data Exchange (ETDEWEB)

    Metcalf, William W. [University of Illinois

    2014-10-08

    This report provides a summary of activities for Award # ER64999, a Genomes to Life Project funded by the Office of Science, Basic Energy Research. The project was entitled "Methanogenic archaea and the global carbon cycle: a systems biology approach to the study of Methanosarcina species". The long-term goal of this multi-investigator project was the creation of integrated, multiscale models that accurately and quantitatively predict the role of Methanosarcina species in the global carbon cycle under dynamic environmental conditions. To achieve these goals we pursed four specific aims: (1) genome sequencing of numerous members of the Order Methanosarcinales, (2) identification of genomic sources of phenotypic variation through in silico comparative genomics, (3) elucidation of the transcriptional networks of two Methanosarcina species, and (4) development of comprehensive metabolic network models for characterized strains to address the question of how metabolic models scale with genetic distance.

  6. Social, structural, behavioral and clinical factors influencing retention in Pre-Exposure Prophylaxis (PrEP) care in Mississippi

    Science.gov (United States)

    Arnold, Trisha; Brinkley-Rubinstein, Lauren; Chan, Philip A.; Perez-Brumer, Amaya; Bologna, Estefany S.; Beauchamps, Laura; Johnson, Kendra; Mena, Leandro; Nunn, Amy

    2017-01-01

    Pre-exposure prophylaxis (PrEP) is a biomedical intervention that can reduce rates of HIV transmission when taken once daily by HIV-negative individuals. Little is understood about PrEP uptake and retention in care among the populations most heavily impacted by the HIV epidemic, particularly among young men who have sex with men (YMSM) in the Deep South. Therefore, this study explored the structural, social, behavioral, and clinical factors that affect PrEP use and retention in care among YMSM in Jackson, Mississippi. Thirty MSM who were prescribed PrEP at an outpatient primary care clinic were interviewed and included 23 men who had been retained in PrEP care and seven who had not been retained. The mean age of participants was 26.6 years. Most (23) participants were African American. Major factors affecting PrEP use and retention in PrEP care included 1) structural factors such as cost and access to financial assistance for medications and clinical services; 2) social factors such as stigma and relationship status; 3) behavioral factors including sexual risk behaviors; and 4) clinical factors such as perceived and actual side effects. Many participants also discussed the positive spillover effects of PrEP use and reported that PrEP had a positive impact on their health. Four of the seven individuals who had not been retained re-enrolled in PrEP care after completing their interviews, suggesting that case management and ongoing outreach can enhance retention in PrEP care. Interventions to enhance retention in PrEP care among MSM in the Deep South will be most effective if they address the complex structural, social, clinical, and behavioral factors that influence PrEP uptake and retention in PrEP care. PMID:28222118

  7. Sulfated dextrans enhance in vitro amplification of bovine spongiform encephalopathy PrP(Sc and enable ultrasensitive detection of bovine PrP(Sc.

    Directory of Open Access Journals (Sweden)

    Yuichi Murayama

    Full Text Available BACKGROUND: Prions, infectious agents associated with prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy (BSE in cattle, and scrapie in sheep and goats, are primarily comprised of PrP(Sc, a protease-resistant misfolded isoform of the cellular prion protein PrP(C. Protein misfolding cyclic amplification (PMCA is a highly sensitive technique used to detect minute amounts of scrapie PrP(Sc. However, the current PMCA technique has been unsuccessful in achieving good amplification in cattle. The detailed distribution of PrP(Sc in BSE-affected cattle therefore remains unknown. METHODOLOGY/PRINCIPAL FINDINGS: We report here that PrP(Sc derived from BSE-affected cattle can be amplified ultra-efficiently by PMCA in the presence of sulfated dextran compounds. This method is capable of amplifying very small amounts of PrP(Sc from the saliva, palatine tonsils, lymph nodes, ileocecal region, and muscular tissues of BSE-affected cattle. Individual differences in the distribution of PrP(Sc in spleen and cerebrospinal fluid samples were observed in terminal-stage animals. However, the presence of PrP(Sc in blood was not substantiated in the BSE-affected cattle examined. CONCLUSIONS/SIGNIFICANCE: The distribution of PrP(Sc is not restricted to the nervous system and can spread to peripheral tissues in the terminal disease stage. The finding that PrP(Sc could be amplified in the saliva of an asymptomatic animal suggests a potential usefulness of this technique for BSE diagnosis. This highly sensitive method also has other practical applications, including safety evaluation or safety assurance of products and byproducts manufactured from bovine source materials.

  8. Protease-resistant PrP and PrP oligomers in the brain in human prion diseases after intraventricular pentosan polysulfate infusion.

    Science.gov (United States)

    Honda, Hiroyuki; Sasaki, Kensuke; Minaki, Haruhiko; Masui, Kenta; Suzuki, Satoshi O; Doh-Ura, Katsumi; Iwaki, Toru

    2012-04-01

    Intraventricular infusion of pentosan polysulfate (PPS) as a treatment for various human prion diseases has been applied in Japan. To evaluate the influence of PPS treatment we performed pathological examination and biochemical analyses of PrP molecules in autopsied brains treated with PPS (one case of sporadic Creutzfeldt-Jakob disease (sCJD, case 1), two cases of dura mater graft-associated CJD (dCJD, cases 2 and 4), and one case of Gerstmann-Sträussler-Scheinker disease (GSS, case 3). Six cases of sCJD without PPS treatment were examined for comparison. Protease-resistant PrP (PrP(res) ) in the frontal lobe was evaluated by Western blotting after proteinase K digestion. Further, the degree of polymerization of PrP molecules was examined by the size-exclusion gel chromatography assay. PPS infusions were started 3-10 months after disease onset, but the treatment did not achieve any clinical improvements. Postmortem examinations of the treated cases revealed symmetrical brain lesions, including neuronal loss, spongiform change and gliosis. Noteworthy was GFAP in the cortical astrocytes reduced in all treated cases despite astrogliosis. Immunohistochemistry for PrP revealed abnormal synaptic deposits in all treated cases and further plaque-type PrP deposition in case 3 of GSS and case 4 of dCJD. Western blotting showed relatively low ratios of PrP(res) in case 2 of dCJD and case 3 of GSS, while in the treated sCJD (case 1), the ratio of PrP(res) was comparable with untreated cases. The indices of oligomeric PrP were reduced in one sCJD (case 1) and one dCJD (case 2). Although intraventricular PPS infusion might modify the accumulation of PrP oligomers in the brains of patients with prion diseases, the therapeutic effects are still uncertain.

  9. Anti-prion drug mPPIg5 inhibits PrP(C conversion to PrP(Sc.

    Directory of Open Access Journals (Sweden)

    James M McCarthy

    Full Text Available Prion diseases, also known as transmissible spongiform encephalopathies, are a group of fatal neurodegenerative diseases that include scrapie in sheep, bovine spongiform encephalopathy (BSE in cattle and Creutzfeldt-Jakob disease (CJD in humans. The 'protein only hypothesis' advocates that PrP(Sc, an abnormal isoform of the cellular protein PrP(C, is the main and possibly sole component of prion infectious agents. Currently, no effective therapy exists for these diseases at the symptomatic phase for either humans or animals, though a number of compounds have demonstrated the ability to eliminate PrPSc in cell culture models. Of particular interest are synthetic polymers known as dendrimers which possess the unique ability to eliminate PrP(Sc in both an intracellular and in vitro setting. The efficacy and mode of action of the novel anti-prion dendrimer mPPIg5 was investigated through the creation of a number of innovative bio-assays based upon the scrapie cell assay. These assays were used to demonstrate that mPPIg5 is a highly effective anti-prion drug which acts, at least in part, through the inhibition of PrP(C to PrP(Sc conversion. Understanding how a drug works is a vital component in maximising its performance. By establishing the efficacy and method of action of mPPIg5, this study will help determine which drugs are most likely to enhance this effect and also aid the design of dendrimers with anti-prion capabilities for the future.

  10. Impact of chromatin structure on PR signaling

    DEFF Research Database (Denmark)

    Grøntved, Lars; Hager, Gordon L

    2012-01-01

    The progesterone receptor (PR) interacts with chromatin in a highly dynamic manner that requires ongoing chromatin remodeling, interaction with chaparones and activity of the proteasome. Here we discuss dynamic interaction of steroid receptor with chromatin, with special attention not only to PR ...

  11. Practical PR for School Media Centers.

    Science.gov (United States)

    Beasley, Augie E.; Palmer, Carolyn G.

    This guide to public relations (PR) for school media specialists begins with a list of 10 "PR Commandments" and suggestions for ways to improve the media center's image, i.e., a media newsletter; renewal workshops; reference skills units; a student brochure; new faculty orientation; media messages; a happenings board; displays, centers, and…

  12. Performance Ratio revisited: Are PR>90% realistic?

    NARCIS (Netherlands)

    Reich, N.H.; Mueller, B.; Armbruster, A.; van Sark, W.G.J.H.M.; Kiefer, K.; Reise, Ch.

    2012-01-01

    In this study, we investigate the performance ratio (PR) of about 100 German photovoltaic system installations. Monitored PR is found to be systematically lower by ~2–4% when calculated with irradiation data obtained by pyranometers (henceforth denoted as PRPyr) as compared with irradiation amounts

  13. Synthetic scrapie infectivity: interaction between recombinant PrP and scrapie brain-derived RNA.

    Science.gov (United States)

    Simoneau, Steve; Thomzig, Achim; Ruchoux, Marie-Madeleine; Vignier, Nicolas; Daus, Martin L; Poleggi, Anna; Lebon, Pierre; Freire, Sophie; Durand, Valerie; Graziano, Silvia; Galeno, Roberta; Cardone, Franco; Comoy, Emmanuel; Pocchiari, Maurizio; Beekes, Michael; Deslys, Jean-Philippe; Fournier, Jean-Guy

    2015-01-01

    The key molecular event in human cerebral proteinopathies, which include Alzheimer's, Parkinson's and Huntington's diseases, is the structural conversion of a specific host protein into a β-sheet-rich conformer. With regards to this common mechanism, it appears difficult to explain the outstanding infectious properties attributed to PrP(Sc), the hallmark of another intriguing family of cerebral proteinopathies known as transmissible spongiform encephalopathies (TSE) or prion diseases. The infectious PrP(Sc) or "prion" is thought to be composed solely of a misfolded form of the otherwise harmless cellular prion protein (PrP(c)). To gain insight into this unique situation, we used the 263K scrapie hamster model to search for a putative PrP(Sc)-associated factor that contributes to the infectivity of PrP(Sc) amyloid. In a rigorously controlled set of experiments that included several bioassays, we showed that originally innocuous recombinant prion protein (recPrP) equivalent to PrP(c) is capable of initiating prion disease in hamsters when it is converted to a prion-like conformation (β-sheet-rich) in the presence of RNA purified from scrapie-associated fibril (SAF) preparations. Analysis of the recPrP-RNA infectious mixture reveals the presence of 2 populations of small RNAs of approximately 27 and 55 nucleotides. These unprecedented findings are discussed in light of the distinct relationship that may exist between this RNA material and the 2 biological properties, infectivity and strain features, attributed to prion amyloid.

  14. En ting er praksis, men er køn noget andet?

    DEFF Research Database (Denmark)

    Hølge-Hazelton, Bibi

    2004-01-01

    Er almen praksis ved at blive ændret i retning af mere feminint orienterede værdier i kraft af den ændrede kønsfordeling, eller skyldes ændringerne, at de yngre praktiserende læger i stigende grad har andre værdier, måske baseret på feminin orientering på baggrund af andre komplekse samfundsmæssi...

  15. Ikon. iPod er kongen over mp3. Hvad er hemmeligheden?

    DEFF Research Database (Denmark)

    Dickson, Thomas

    2005-01-01

    iPod er blevet ikonet for det 21. århundrede. Men iPod var hverken den første mp3-afspiller eller den første veldesignede af slagsen. Før iPod så dagens lys var Bang & Olufsen på banen med sin næsten lige så lækre BeoSound2....

  16. "Det man hører, er man selv" - musik og identitet set gennem musikforskningens briller

    Directory of Open Access Journals (Sweden)

    Lars Ole Bonde

    2015-11-01

    Full Text Available ”Det man hører, er man selv” er Danmarks Radios P3s yderst velkendte slogan. Det dukkede op i begyndelsen af (2000’erne som opfindsom og populær afspejling af en moderne forståelse af den rolle musik og medieforbrug spiller for den voksne dansker. Denne artikel handler ikke om P3 som musikkanal, men går bag om det populære slogan og undersøger hvordan musik og identitet spiller sammen. Hvilke (musikpsykologiske teorier belyser musikkens rolle i identitetsdannelsen? Hvordan forskes der i emnet, og hvilke resultater kan der peges på? Forskningen dokumenterer bl.a., at musik bruges aktivt af mange mennesker som en ressource til at konstruere selv-identitet og gruppe-identitet, og til at skabe, opretholde og regulere en mangfoldighed af følelser. Denne oversigtsartikel giver via præsentation af udvalgte teorier og konkrete undersøgelser en bred introduktion til emnet og viser, hvordan musikforskere gennem arbejde med interviews, dagbøger og (musikalske selvbiografier samt feltarbejde kan beskrive musik som en ofte meget vigtig brik i identitetsdannelsen.

  17. "Det man hører, er man selv" - musik og identitet set gennem musikforskningens briller

    Directory of Open Access Journals (Sweden)

    Lars Ole Bonde

    2015-11-01

    Full Text Available ”Det man hører, er man selv” er Danmarks Radios P3s yderst velkendte slogan. Det dukkede op i begyndelsen af (2000’erne som opfindsom og populær afspejling af en moderne forståelse af den rolle musik og medieforbrug spiller for den voksne dansker. Denne artikel handler ikke om P3 som musikkanal, men går bag om det populære slogan og undersøger hvordan musik og identitet spiller sammen. Hvilke (musikpsykologiske teorier belyser musikkens rolle i identitetsdannelsen? Hvordan forskes der i emnet, og hvilke resultater kan der peges på? Forskningen dokumenterer bl.a., at musik bruges aktivt af mange mennesker som en ressource til at konstruere selv-identitet og gruppe-identitet, og til at skabe, opretholde og regulere en mangfoldighed af følelser. Denne oversigtsartikel giver via præsentation af udvalgte teorier og konkrete undersøgelser en bred introduktion til emnet og viser, hvordan musikforskere gennem arbejde med interviews, dagbøger og (musikalske selvbiografier samt feltarbejde kan beskrive musik som en ofte meget vigtig brik i identitetsdannelsen.

  18. Dificultades del amor erótico en los lazos de inclusión

    Directory of Open Access Journals (Sweden)

    Maria Alves de Toledo Bruns

    2016-01-01

    Full Text Available El erotismo, una creación cultural de cada sociedad, se dio en el proceso de evolución de las especies a través del dominio del instinto sexual reproductor por el hombre transformándolo en una representación mediada en el y por el conjunto de censuras, prácticas, rituales, mitos y tabúes, lo que nos separa de los demás animales. Es experimentado por individuos considerados “normales” y por individuos discapacitados de distintas etnias, culturas, edades y clases sociales. Intento propiciar una reflexión acerca del ethos del patriarcado presente en las dificultades encontradas por los individuos al experimentar el amor erótico. Creo que es importante invertir en políticas públicas para cambiar del paradigma que considera la discapacidad como fenómeno individual al paradigma de las diversidades educativas, sociales, políticas y sexuales; expandir la información en el ámbito familiar, educativo y de los medios, para crear nuevas estructuras de experiencia del amor erótico.

  19. Kollektiv handling er på retræte

    DEFF Research Database (Denmark)

    Ibsen, Flemming; Høgedahl, Laust; Scheuer, Steen

    2011-01-01

    , har en mening. Men mener man dette, skal man være klar over, at de alternative organisationer ikke bidrager til det overordnede systems vedligeholdelse. Desuden er de alternative organisationer ikke tilhængere af konflikt- og strejkeretten, som ellers er en del af både EU-retten og ILO’s konventioner....

  20. Det man hører, er man selv

    DEFF Research Database (Denmark)

    Svømmekjær, Heidi Frank

    2012-01-01

    Katalog til udstillingen "Det man hører, er man selv" på Mediemuseet i Odense 7. september 2012 - 15. januar 2013.......Katalog til udstillingen "Det man hører, er man selv" på Mediemuseet i Odense 7. september 2012 - 15. januar 2013....