Stāstu stāstīšanas izmantošana lasīšanas veicināšanas pasākumos

OpenAIRE

Mežjāne, Signe

2014-01-01

Bakalaura darba mērķis ir noskaidrot, vai stāstu stāstīšana ir efektīvs lasīšanas veicināšanas paņēmiens bērniem. Pētījuma problēma ir mūsdienu bērnu nevēlēšanās lasīt, lasīšanu varētu veicināt stāstu stāstīšana bibliotēkās. Darbā tiek analizēts stāstu stāstīšanas process atbilstoši bērnu vecumposmam, izmantojot dažādus runas stilus. Teorētiskā bāze ir balstīta uz Lasītāja reakcijas kritikas teoriju un Runas darbības teoriju. Galvenie pētījuma uzdevumi ir noskaidrot, vai Latvijas bibliotē...

75 FR 51945 - Safety Zone; Potomac River, St. Mary's River, St. Inigoes, MD

Science.gov (United States)

2010-08-24

...-AA00 Safety Zone; Potomac River, St. Mary's River, St. Inigoes, MD AGENCY: Coast Guard, DHS. ACTION... of the St. Mary's River, a tributary of the Potomac River. This action is necessary to provide for.... Navy helicopter located near St. Inigoes, Maryland. This safety zone is intended to protect the...

Materials for the 21st century

CERN Document Server

Segal, David

2017-01-01

The book is a general text that shows how materials can contribute to solving problems facing nations in the 21st century. It is illustrated with diverse applications and highlights the potential of existing materials for everyday life, healthcare and the economies of nations. There are 13 chapters and a glossary of 500 materials with their descriptions, historical development, their use or potential use and a range of references. Specific areas include synthetic polymers (e.g. nylon), natural polymers (e.g. proteins, cellulose) and the role of materials in the development of digital computers and in healthcare. Solid-state lighting, energy supplies in the 21st century, disruptive technologies and intellectual property, in particular patents, are discussed. The book concludes by asking how the 21st century will be characterised. Will it be the Silicon Age, Genomic Age or New Polymer Age, as examples?

Morphing into a 21st Century Trainer.

Science.gov (United States)

Mager, R. F.

1996-01-01

Forces that will affect trainers into the next century include rapid change, information overload, globalization, downsizing, empowerment, and remote worksites. Key characteristics of a 21st-century trainer include performance orientation, technical skills, social skills, self-employability, bilingualism, and international competence. (JOW)

ST Elevation in aVR with Coexistent Multilead ST Depression

Directory of Open Access Journals (Sweden)

Benjamin Cooper

2017-01-01

Full Text Available History of present illness: An 80-year-old female with a history of Crohn’s disease presented to the emergency department with chest pain. She had two weeks of exertional chest pain that preceded an episode of chest pain immediately prior to arrival associated with diaphoresis. Her pain nearly completely resolved with sublingual nitroglycerin provided by pre-hospital personnel. She was hemodynamically stable with normal vital signs on arrival. An ECG was immediately obtained. Significant findings: The ECG shows ST-segment depressions in precordial leads V3 through V6, and limb leads I, II, and aVL, and 1 mm of ST-segment elevation in aVR. The initial troponin I was elevated at 1.37 ng/mL (upper limit of normal 0.40. Cardiology decided to delay catheterization until the next day when diffuse coronary disease was discovered (including 90% of the left circumflex stenosis, 60% proximal and 75% mid-left anterior descending stenosis, 75% third diagonal branch stenosis, and 90% posterior descending artery stenosis. The following day, the patient went to the operating room for coronary artery bypass grafting (CABG. Discussion: Traditionally, lead aVR has not received attention when interpreting acutely ischemic changes on ECG, leading some to refer to it as “the forgotten lead.”1 Current guidelines acknowledge the significance of multilead ST depression with coexistent ST elevation in aVR, and this pattern has been identified as the strongest predictor of severe left main coronary artery and/or 3-vessel disease (LM/3VD.2-3 When this ECG pattern is recognized in patients with ischemic symptoms, the emergency physician should involve cardiology early. When managing patients with suspected LM/3VD, it is important to withhold dual anti-platelet therapy as CABG is likely to be indicated,1,3 and guidelines recommend discontinuing P2Y12 inhibitors like clopidogrel or ticagrelor at least 24 hours prior to urgent CABG.2

78 FR 19632 - Special Local Regulations; St. Thomas Carnival Watersport Activities, Charlotte Amalie Harbor; St...

Science.gov (United States)

2013-04-02

...-AA08 Special Local Regulations; St. Thomas Carnival Watersport Activities, Charlotte Amalie Harbor; St... proposes to establish a special local regulation on the waters of Charlotte Amalie Harbor in St Thomas, USVI during the St. Thomas Carnival Watersport Activities, a high speed boat race. The event is...

Constructive singularities and energy efficiency of St. Petersburg historic circuses

Science.gov (United States)

Sysoeva, Elena; Trushina, Ekaterina

2017-10-01

The article is devoted to the design and construction of St. Petersburg circuses during the period since 1822 till nowadays. The article presents the characteristics of all eight historic buildings of St. Petersburg and their structural and architectural features. The article raises some issues of energy-optimal shape of a building on the example of St. Petersburg modern circus building. There are several historical drawings and photographs of the circus buildings. The article includes overview of normative regulation of circus buildings in Russia since the middle of the twentieth century and prospects for the future.

ACRR fission product release tests: ST-1 and ST-2

International Nuclear Information System (INIS)

Allen, M.D.; Stockman, H.W.; Reil, K.O.; Grimley, A.J.; Camp, W.J.

1988-01-01

Two experiments (ST-1 and ST-2) have been performed in the Annular Core Research Reactor (ACRR) at Sandia National Laboratories (SNLA) to obtain time-resolved data on the release of fission products from irradiated fuels under light water reactor (LWR) severe accident conditions. Both experiments were conducted in a highly reducing environment at maximum fuel temperatures of greater than 2400 K. These experiments were designed specifically to investigate the effect of increased total pressure on fission product release; ST-1 was performed at approximately 0.16 MPa and ST-2 was run at 1.9 MPa, whereas other parameters were matched as closely as possible. Release rate data were measured for Cs, I, Ba, Sr, Eu, Te, and U. The release rates were higher than predicted by existing codes for Ba, Sr, Eu, and U. Te release was very low, but Te did not appear to be sequestered by the zircaloy cladding; it was evenly distributed in the fuel. In addition, in posttest analysis a unique fuel morphology (fuel swelling) was observed which may have enhanced fission product release, especially in the high pressure test (ST-2). These data are compared with analytical results from the CORSOR correlation and the VICTORIA computer model

Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258: a systematic review and meta-analysis

Science.gov (United States)

Dautzenberg, M J D; Haverkate, M R; Bonten, M J M; Bootsma, M C J

2016-01-01

Objectives Observational studies have suggested that Escherichia coli sequence type (ST) 131 and Klebsiella pneumoniae ST258 have hyperendemic properties. This would be obvious from continuously high incidence and/or prevalence of carriage or infection with these bacteria in specific patient populations. Hyperendemicity could result from increased transmissibility, longer duration of infectiousness, and/or higher pathogenic potential as compared with other lineages of the same species. The aim of our research is to quantitatively estimate these critical parameters for E. coli ST131 and K. pneumoniae ST258, in order to investigate whether E. coli ST131 and K. pneumoniae ST258 are truly hyperendemic clones. Primary outcome measures A systematic literature search was performed to assess the evidence of transmissibility, duration of infectiousness, and pathogenicity for E. coli ST131 and K. pneumoniae ST258. Meta-regression was performed to quantify these characteristics. Results The systematic literature search yielded 639 articles, of which 19 data sources provided information on transmissibility (E. coli ST131 n=9; K. pneumoniae ST258 n=10)), 2 on duration of infectiousness (E. coli ST131 n=2), and 324 on pathogenicity (E. coli ST131 n=285; K. pneumoniae ST258 n=39). Available data on duration of carriage and on transmissibility were insufficient for quantitative assessment. In multivariable meta-regression E. coli isolates causing infection were associated with ST131, compared to isolates only causing colonisation, suggesting that E. coli ST131 can be considered more pathogenic than non-ST131 isolates. Date of isolation, location and resistance mechanism also influenced the prevalence of ST131. E. coli ST131 was 3.2 (95% CI 2.0 to 5.0) times more pathogenic than non-ST131. For K. pneumoniae ST258 there were not enough data for meta-regression assessing the influence of colonisation versus infection on ST258 prevalence. Conclusions With the currently available data

Inferior ST-Elevation Myocardial Infarction Associated with Takotsubo Cardiomyopathy

Directory of Open Access Journals (Sweden)

Oliver Koeth

2010-01-01

Full Text Available Takotsubo cardiomyopathy (TCM is usually characterized by transient left ventricular apical ballooning. Due to the clinical symptoms which include chest pain, electrocardiographic changes, and elevated myocardial markers, Takotsubo cardiomyopathy is frequently mimicking ST-elevation myocardial infarction in the absence of a significant coronary artery disease. Otherwise an acute occlusion of the left anterior descending coronary artery can produce a typical Takotsubo contraction pattern. ST-elevation myocardial infarction (STEMI is frequently associated with emotional stress, but to date no cases of STEMI triggering TCM have been reported. We describe a case of a female patient with inferior ST-elevation myocardial infarction complicated by TCM.

Flora of St Katherine Protectorate: key to families and genera ...

African Journals Online (AJOL)

An illustrated key to families and genera of the flora of the St Katherine Protectorate is provided to facilitate the identification of the unique flora of the area, based on five years of collecting mainly in the mountains and wadis surrounding the town of St Katherine. The key includes 43 families and 141 genera, the families ...

33 CFR 100.915 - St. Clair River Classic Offshore Race, St. Clair, MI.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Clair River Classic Offshore Race, St. Clair, MI. 100.915 Section 100.915 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.915 St. Clair River...

33 CFR 110.250 - St. Thomas Harbor, Charlotte Amalie, V.I.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Thomas Harbor, Charlotte... SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.250 St. Thomas Harbor, Charlotte Amalie.... Thomas, V.I. of the United States and approaches thereto, including all waters under its jurisdiction, as...

St2-80: a new FISH marker for St genome and genome analysis in Triticeae.

Science.gov (United States)

Wang, Long; Shi, Qinghua; Su, Handong; Wang, Yi; Sha, Lina; Fan, Xing; Kang, Houyang; Zhang, Haiqin; Zhou, Yonghong

2017-07-01

The St genome is one of the most fundamental genomes in Triticeae. Repetitive sequences are widely used to distinguish different genomes or species. The primary objectives of this study were to (i) screen a new sequence that could easily distinguish the chromosome of the St genome from those of other genomes by fluorescence in situ hybridization (FISH) and (ii) investigate the genome constitution of some species that remain uncertain and controversial. We used degenerated oligonucleotide primer PCR (Dop-PCR), Dot-blot, and FISH to screen for a new marker of the St genome and to test the efficiency of this marker in the detection of the St chromosome at different ploidy levels. Signals produced by a new FISH marker (denoted St 2 -80) were present on the entire arm of chromosomes of the St genome, except in the centromeric region. On the contrary, St 2 -80 signals were present in the terminal region of chromosomes of the E, H, P, and Y genomes. No signal was detected in the A and B genomes, and only weak signals were detected in the terminal region of chromosomes of the D genome. St 2 -80 signals were obvious and stable in chromosomes of different genomes, whether diploid or polyploid. Therefore, St 2 -80 is a potential and useful FISH marker that can be used to distinguish the St genome from those of other genomes in Triticeae.

Increased serum concentrations of soluble ST2 predict mortality after burn injury.

Science.gov (United States)

Hacker, Stefan; Dieplinger, Benjamin; Werba, Gregor; Nickl, Stefanie; Roth, Georg A; Krenn, Claus G; Mueller, Thomas; Ankersmit, Hendrik J; Haider, Thomas

2018-06-27

Large burn injuries induce a systemic response in affected patients. Soluble ST2 (sST2) acts as a decoy receptor for interleukin-33 (IL-33) and has immunosuppressive effects. sST2 has been described previously as a prognostic serum marker. Our aim was to evaluate serum concentrations of sST2 and IL-33 after thermal injury and elucidate whether sST2 is associated with mortality in these patients. We included 32 burn patients (total body surface area [TBSA] >10%) admitted to our burn intensive care unit and compared them to eight healthy probands. Serum concentrations of sST2 and IL-33 were measured serially using an enzyme-linked immunosorbent assay (ELISA) technique. The mean TBSA was 32.5%±19.6%. Six patients (18.8%) died during the hospital stay. Serum analyses showed significantly increased concentrations of sST2 and reduced concentrations of IL-33 in burn patients compared to healthy controls. In our study cohort, higher serum concentrations of sST2 were a strong independent predictor of mortality. Burn injuries cause an increment of sST2 serum concentrations with a concomitant reduction of IL-33. Higher concentrations of sST2 are associated with increased in-hospital mortality in burn patients.

76 FR 44531 - Safety Zone; Fourth Annual Chillounge Night St. Petersburg Fireworks Display, Tampa Bay, St...

Science.gov (United States)

2011-07-26

...-AA00 Safety Zone; Fourth Annual Chillounge Night St. Petersburg Fireworks Display, Tampa Bay, St... proposes to establish a temporary safety zone on the waters of Tampa Bay in St. Petersburg, Florida during the Fourth Annual Chillounge Night St. Petersburg Fireworks Display on Saturday, November 19, 2011...

76 FR 68098 - Safety Zone; Fourth Annual Chillounge Night St. Petersburg Fireworks Display, Tampa Bay, St...

Science.gov (United States)

2011-11-03

...-AA00 Safety Zone; Fourth Annual Chillounge Night St. Petersburg Fireworks Display, Tampa Bay, St... Guard is establishing a temporary safety zone on the waters of Tampa Bay in St. Petersburg, Florida during the Fourth Annual Chillounge Night St. Petersburg Fireworks Display on Saturday, November 19, 2011...

Housing Service: Receptions of the CERN and St.-Genis-Pouilly Hostels

CERN Multimedia

2005-01-01

Opening times Please note the new and definitive opening times of the Receptions of the hostels on the Swiss site of CERN and in St. Genis : CERN hostels St.-Genis hostel from Monday to Friday 7:30 - 19:30 8:00 - 12:00 16:00 - 19:00 Saturday 9:00 - 13:00 closed Sunday 9:00 - 13:00 closed Outside these times keys to rooms reserved in advance can be obtained from the guards on duty at the main entrance to the Meyrin, Switzerland, CERN site (Gate B), where they are deposited some fifteen minutes after the closure of the Reception. As for the St. Genis hostel, for arrivals on Saturdays and Sundays, the keys are deposited with the guards in advance on the preceding Friday evening. Reminder : reservations, whether for the CERN hostels or the St. Genis hostel, are available through the Reception of the CERN hostels. Once the reservation has been confirmed, in the case of St. Genis, all other business, including payment, is dealt with by the St. Genis hostel reception. As far as possible, all r...

Aiming Talent Development toward Creative Eminence in the 21st Century

Science.gov (United States)

Olszewski-Kubilius, Paula; Subotnik, Rena F.; Worrell, Frank C.

2016-01-01

Much has been written about the social and scientific problems that face the world in the 21st century, including climate change and economic inequality. In this context, the development of talented individuals who can tackle these problems is most important. In this article, the authors discuss the implications of 21st-century challenges for the…

From 21st century skills to 21st century human being

DEFF Research Database (Denmark)

Hjøllund, Niels-Peder Osmundsen; Jørgensen, Tobias Heiberg

2017-01-01

In Denmark, in Scandinavia and in all of Europe there is a lot of talk about the skills of the future. But if we want our students to aim for and gain a different learning outcome, we must set new and different standards for the way we teach – and start to walk the talk. The focus of the presenta...... CLD and we must take the next step, where we stop thinking about skills and competencies and start thinking and acting on the fundamental existential implication of the 21st century. What we need now is not more 21st century skills, but 21st century human beings....

76 FR 55158 - Approval of Noise Compatibility Program for Lambert-St. Louis International Airport, St. Louis, MO

Science.gov (United States)

2011-09-06

... Program for Lambert-St. Louis International Airport, St. Louis, MO AGENCY: Federal Aviation Administration... noise compatibility program submitted by the St. Louis Airport Authority under the provisions of 49 U.S...''). On April 5, 2011, the FAA determined that the noise exposure maps submitted by the St. Louis Airport...

The spread of KPC-producing Enterobacteriaceae in Spain: WGS analysis of the emerging high-risk clones of Klebsiella pneumoniae ST11/KPC-2, ST101/KPC-2 and ST512/KPC-3.

Science.gov (United States)

Oteo, Jesús; Pérez-Vázquez, María; Bautista, Verónica; Ortega, Adriana; Zamarrón, Pilar; Saez, David; Fernández-Romero, Sara; Lara, Noelia; Ramiro, Raquel; Aracil, Belén; Campos, José

2016-12-01

We analysed the microbiological traits and population structure of KPC-producing Enterobacteriaceae isolates collected in Spain between 2012 and 2014. We also performed a comparative WGS analysis of the three major KPC-producing Klebsiella pneumoniae clones detected. Carbapenemase and ESBL genes were sequenced. The Institut Pasteur MLST scheme was used. WGS data were used to construct phylogenetic trees, to identify the determinants of resistance and to de novo assemble the genome of one representative isolate of each of the three major K. pneumoniae clones. Of the 2443 carbapenemase-producing Enterobacteriaceae isolates identified during the study period, 111 (4.5%) produced KPC. Of these, 81 (73.0%) were K. pneumoniae and 13 (11.7%) were Enterobacter cloacae. Three major epidemic clones of K. pneumoniae were identified: ST11/KPC-2, ST101/KPC-2 and ST512/KPC-3. ST11/KPC-2 differed from ST101/KPC-2 and ST512/KPC-3 by 27 819 and 6924 SNPs, respectively. ST101/KPC-2 differed from ST512/KPC-3 by 28 345 SNPs. Nine acquired resistance genes were found in ST11/KPC-2, 11 in ST512/KPC-3 and 13 in ST101/KPC-2. ST101/KPC-2 had the highest number of virulence genes (20). An 11 bp deletion at the end of the mgrB sequence was the cause of colistin resistance in ST512/KPC-3. KPC-producing Enterobacteriaceae are increasing in Spain. Most KPC-producing K. pneumoniae isolates belonged to only five clones: ST11 and ST512 caused interregional spread, ST101 caused regional spread and ST1961 and ST678 produced independent hospital outbreaks. ST101/KPC-2 had the highest number of resistance and virulence genes. ST101/KPC-2 and ST512/KPC-3 were recently implicated in the spread of KPC in Italy. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Team Danmarks støttekoncept

DEFF Research Database (Denmark)

Storm, Rasmus K.

Evaluering af Team Danmarks støttekoncept 2005-2008 med omfattende analyser af Team Danmarks virke, dets støttekoncept og de samarbejdsrelationer med specialforbund, udøvere, politisk valgte ledere, trænere mv., som udmøntningen af støttekonceptet forudsætter. Herunder analyse af...

Ocular Toxicity Profile of ST-162 and ST-168 as Novel Bifunctional MEK/PI3K Inhibitors.

Science.gov (United States)

Smith, Andrew; Pawar, Mercy; Van Dort, Marcian E; Galbán, Stefanie; Welton, Amanda R; Thurber, Greg M; Ross, Brian D; Besirli, Cagri G

2018-04-30

ST-162 and ST-168 are small-molecule bifunctional inhibitors of MEK and PI3K signaling pathways that are being developed as novel antitumor agents. Previous small-molecule and biologic MEK inhibitors demonstrated ocular toxicity events that were dose limiting in clinical studies. We evaluated in vitro and in vivo ocular toxicity profiles of ST-162 and ST-168. Photoreceptor cell line 661W and adult retinal pigment epithelium cell line ARPE-19 were treated with increasing concentrations of bifunctional inhibitors. Western blots, cell viability, and caspase activity assays were performed to evaluate MEK and PI3K inhibition and dose-dependent in vitro toxicity, and compared with monotherapy. In vivo toxicity profile was assessed by intravitreal injection of ST-162 and ST-168 in Dutch-Belted rabbits, followed by ocular examination and histological analysis of enucleated eyes. Retinal cell lines treated with ST-162 or ST-168 exhibited dose-dependent inhibition of MEK and PI3K signaling. Compared with inhibition by monotherapies and their combinations, bifunctional inhibitors demonstrated reduced cell death and caspase activity. In vivo, both bifunctional inhibitors exhibited a more favorable toxicity profile when compared with MEK inhibitor PD0325901. Novel MEK and PI3K bifunctional inhibitors ST-162 and ST-168 demonstrate favorable in vitro and in vivo ocular toxicity profiles, supporting their further development as potential therapeutic agents targeting multiple aggressive tumors.

St. John's Wort (image)

Science.gov (United States)

The herb St. John's Wort is believed to be helpful in relieving mild to moderate depression, but should only be taken under a physician's supervision. St. John's Wort may clash with other medications or ...

ACHP | News | St. Elizabeths Programmatic Agreement Signed

Science.gov (United States)

Search skip specific nav links Home arrow News arrow St. Elizabeths Programmatic Agreement Signed St redevelopment of the St. Elizabeths West Campus, which is part of the St. Elizabeths National Historic Landmark this project, due to the historic significance of the NHL. GSA's client for the St. Elizabeths

First genome report on novel sequence types of Neisseria meningitidis: ST12777 and ST12778.

Science.gov (United States)

Veeraraghavan, Balaji; Lal, Binesh; Devanga Ragupathi, Naveen Kumar; Neeravi, Iyyan Raj; Jeyaraman, Ranjith; Varghese, Rosemol; Paul, Miracle Magdalene; Baskaran, Ashtawarthani; Ranjan, Ranjini

2018-03-01

Neisseria meningitidis is an important causative agent of meningitis and/or sepsis with high morbidity and mortality. Baseline genome data on N. meningitidis, especially from developing countries such as India, are lacking. This study aimed to investigate the whole genome sequences of N. meningitidis isolates from a tertiary care centre in India. Whole-genome sequencing was performed using an Ion Torrent™ Personal Genome Machine™ (PGM) with 400-bp chemistry. Data were assembled de novo using SPAdes Genome Assembler v.5.0.0.0. Sequence annotation was performed through PATRIC, RAST and the NCBI PGAAP server. Downstream analysis of the isolates was performed using the Center for Genomic Epidemiology databases for antimicrobial resistance genes and sequence types. Virulence factors and CRISPR were analysed using the PubMLST database and CRISPRFinder, respectively. This study reports the whole genome shotgun sequences of eight N. meningitidis isolates from bloodstream infections. The genome data revealed two novel sequence types (ST12777 and ST12778), along with ST11, ST437 and ST6928. The virulence profile of the isolates matched their sequence types. All isolates were negative for plasmid-mediated resistance genes. To the best of our knowledge, this is the first report of ST11 and ST437 N. meningitidis isolates in India along with two novel sequence types (ST12777 and ST12778). These results indicate that the sequence types circulating in India are diverse and require continuous monitoring. Further studies strengthening the genome data on N. meningitidis are required to understand the prevalence, spread, exact resistance and virulence mechanisms along with serotypes. Copyright © 2017 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.

78 FR 7663 - SLR; 2013 International Rolex Regatta; St. Thomas Harbor; St. Thomas, U.S. Virgin Islands

Science.gov (United States)

2013-02-04

... 1625-AA08 SLR; 2013 International Rolex Regatta; St. Thomas Harbor; St. Thomas, U.S. Virgin Islands... special local regulations on the waters of St. Thomas Harbor in St. Thomas, U. S. Virgin Islands during... 5 p.m., Monday through Friday, except federal holidays. The telephone number is 202-366-9329. See...

33 CFR 207.440 - St. Marys Falls Canal and Locks, Mich.; use, administration, and navigation.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false St. Marys Falls Canal and Locks... CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.440 St... include all of the natural waters of the St. Marys River on the U.S. side of the International Boundary...

Isolation and characterization of styrene metabolism genes from styrene-assimilating soil bacteria Rhodococcus sp. ST-5 and ST-10.

Science.gov (United States)

Toda, Hiroshi; Itoh, Nobuya

2012-01-01

Styrene metabolism genes were isolated from styrene-assimilating bacteria Rhodococcus sp. ST-5 and ST-10. Strain ST-5 had a gene cluster containing four open reading frames which encoded styrene degradation enzymes. The genes showed high similarity to styABCD of Pseudomonas sp. Y2. On the other hand, strain ST-10 had only two genes which encoded styrene monooxygenase and flavin oxidoreductase (styAB). Escherichia coli transformants possessing the sty genes of strains ST-5 and ST-10 produced (S)-styrene oxide from styrene, indicating that these genes function as styrene degradation enzymes. Metabolite analysis by resting-cell reaction with gas chromatography-mass spectrometry revealed that strain ST-5 converts styrene to phenylacetaldehyde via styrene oxide by styrene oxide isomerase (styC) reaction. On the other hand, strain ST-10 lacked this enzyme, and thus accumulated styrene oxide as an intermediate. HPLC analysis showed that styrene oxide was spontaneously isomerized to phenylacetaldehyde by chemical reaction. The produced phenylacetaldehyde was converted to phenylacetic acid (PAA) in strain ST-10 as well as in strain ST-5. Furthermore, phenylacetic acid was converted to phenylacetyl-CoA by the catalysis of phenylacetate-CoA ligase in strains ST-5 and ST-10. This study proposes possible styrene metabolism pathways in Rhodococcus sp. strains ST-5 and ST-10. Copyright © 2011 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Identifying 21st Century Capabilities

Science.gov (United States)

Stevens, Robert

2012-01-01

What are the capabilities necessary to meet 21st century challenges? Much of the literature on 21st century skills focuses on skills necessary to meet those challenges associated with future work in a globalised world. The result is a limited characterisation of those capabilities necessary to address 21st century social, health and particularly…

Department of Energy: Nuclear S&T workforce development programs

International Nuclear Information System (INIS)

Bingham, Michelle; Bala, Marsha; Beierschmitt, Kelly; Steele, Carolyn; Sattelberger, Alfred P.; Bruozas, Meridith A.

2016-01-01

The U.S. Department of Energy (DOE) national laboratories use their expertise in nuclear science and technology (S&T) to support a robust national nuclear S&T enterprise from the ground up. Traditional academic programs do not provide all the elements necessary to develop this expertise, so the DOE has initiated a number of supplemental programs to develop and support the nuclear S&T workforce pipeline. This document catalogs existing workforce development programs that are supported by a number of DOE offices (such as the Offices of Nuclear Energy, Science, Energy Efficiency, and Environmental Management), and by the National Nuclear Security Administration (NNSA) and the Naval Reactor Program. Workforce development programs in nuclear S&T administered through the Department of Homeland Security, the Nuclear Regulatory Commission, and the Department of Defense are also included. The information about these programs, which is cataloged below, is drawn from the program websites. Some programs, such as the Minority Serving Institutes Partnership Programs (MSIPPs) are available through more than one DOE office, so they appear in more than one section of this document.

If F(ST) does not measure neutral genetic differentiation, then comparing it with Q(ST) is misleading. Or is it?

Science.gov (United States)

Edelaar, Pim; Björklund, Mats

2011-05-01

The comparison between neutral genetic differentiation (F(ST) ) and quantitative genetic differentiation (Q(ST) ) is commonly used to test for signatures of selection in population divergence. However, there is an ongoing discussion about what F(ST) actually measures, even resulting in some alternative metrics to express neutral genetic differentiation. If there is a problem with F(ST) , this could have repercussions for its comparison with Q(ST) as well. We show that as the mutation rate of the neutral marker increases, F(ST) decreases: a higher within-population heterozygosity (He) yields a lower F(ST) value. However, the same is true for Q(ST) : a higher mutation rate for the underlying QTL also results in a lower Q(ST) estimate. The effect of mutation rate is equivalent in Q(ST) and F(ST) . Hence, the comparison between Q(ST) and F(ST) remains valid, if one uses neutral markers whose mutation rates are not too high compared to those of quantitative traits. Usage of highly variable neutral markers such as hypervariable microsatellites can lead to serious biases and the incorrect inference that divergent selection has acted on populations. Much of the discussion on F(ST) seems to stem from the misunderstanding that it measures the differentiation of populations, whereas it actually measures the fixation of alleles. In their capacity as measures of population differentiation, Hedrick's G'(ST) and Jost's D reach their maximum value of 1 when populations do not share alleles even when there remains variation within populations, which invalidates them for comparisons with Q(ST) . © 2011 Blackwell Publishing Ltd.

Molecular evidence for the thriving of Campylobacter jejuni ST-4526 in Japan.

Directory of Open Access Journals (Sweden)

Hiroshi Asakura

Full Text Available Campylobacter jejuni is a leading cause of human gastroenteritis worldwide. This study aimed at a better understanding of the genetic diversity of this pathogen disseminated in Japan. We performed multilocus sequence typing (MLST of Campylobacter jejuni isolated from different sources (100 human, 61 poultry, and 51 cattle isolates in Japan between 2005 and 2006. This approach identified 62 sequence types (STs and 19 clonal complexes (CCs, including 11 novel STs. These 62 STs were phylogenetically divided into 6 clusters, partially exhibiting host association. We identified a novel ST (ST-4526 that has never been reported in other countries; a phylogenetic analysis showed that ST-4526 and related STs showed distant lineage from the founder ST, ST-21 within CC-21. Comparative genome analysis was performed to investigate which properties could be responsible for the successful dissemination of ST-4526 in Japan. Results revealed that three representative ST-4526 isolates contained a putative island comprising the region from Cj0737 to Cj0744, which differed between the ST-4526 isolates and the reference strain NCTC11168 (ST-43/CC-21. Amino acid sequence alignment analyses showed that two of three ST-4526 isolates expressed 693aa- filamentous hemagglutination domain protein (FHA, while most of other C. jejuni strains whose genome were sequenced exhibited its truncation. Correspondingly, host cell binding of FHA-positive C. jejuni was greater than that of FHA-truncated strains, and exogenous administration of rFHA protein reduced cell adhesion of FHA-positive bacteria. Biochemical assays showed that this putative protein exhibited a dose-dependent binding affinity to heparan sulfate, indicating its adhesin activity. Moreover, ST-4526 showed increased antibiotic-resistance (nalidixic acid and fluoroquinolones and a reduced ability for DNA uptake. Taken together, our data suggested that these combined features contributed to the clonal thriving of ST

St. Thomas and St. John, U.S. Virgin Islands Coastal Digital Elevation Model

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The 1/3 arc-second St. Thomas and St. John, U.S. Virgin Islands Coastal Digital Elevation Model will be used to support NOAA's tsunami forecast system and for...

Radioimmunoimaging of human colon and gastric cancers xenografts by NCC-ST-439 and NCC-ST-433 monoclonal antibodies

International Nuclear Information System (INIS)

Nakamura, Kayoko; Tsukatani, Yasushi; Nishiguchi, Iku

1987-01-01

Both NCC-ST-439 and NCC-ST-433 are monoclonal antibodies raised against human gastric cancer (St-4) xenografts in nude mice. Imaging and localization experiments were performed by injecting I-125 labeled antibodies into nude mice bearing CO-4 (colon carcinoma) and H-111 (gastric carcinoma). There was uptake of NCC-ST-439 (polymer) into the CO-4, though it was not clearly visualized until 5 days post injection. By injecting NCC-ST-439 (monomer), CO-4 was better seen at day 3, while average accumulation into the tumors decreased compared with NCC-ST-439 (polymer). High radioactivities were observed in the liver and spleen, which was probably due to the immunocomplex with the antigen in the blood. NCC-ST-433 was selectively accumulated into the H-111 with tumor to blood ratio 7.8 at day 7, without significant uptake into the liver and spleen. Significant correlation was also found between the tumor uptake level of NCC-ST-433 and size of tumors. Excellent images of H-111 were obtained 3 days after the injection. NCC-ST-433 holds promise for the radioimmunodetection of gastric cancers. (author)

Draft Genome Sequences of Staphylococcus aureus AMRF1 (ST22) and AMRF2 (ST672), Ocular Methicillin-Resistant Isolates

KAUST Repository

Velusamy, Nithya

2014-03-20

Sequence type 22 (ST22) and ST672 are the two major emerging clones of community-acquired methicillin-resistant Staphylococcus aureus in India. ST672 strains were found to cause severe ocular infections. We report the draft genome sequences of two emerging strains of methicillin-resistant S. aureus, AMRF1 (ST22) and AMRF2 (ST672), isolated from patients with ocular infections.

Draft Genome Sequences of Staphylococcus aureus AMRF1 (ST22) and AMRF2 (ST672), Ocular Methicillin-Resistant Isolates

KAUST Repository

Velusamy, Nithya; Prakash, Logambiga; Neelamegam, Sivakumar; Antony, Aju; Prajna, Lalitha; Mohankumar, Vidyarani; Devarajan, Bharanidharan

2014-01-01

Sequence type 22 (ST22) and ST672 are the two major emerging clones of community-acquired methicillin-resistant Staphylococcus aureus in India. ST672 strains were found to cause severe ocular infections. We report the draft genome sequences of two emerging strains of methicillin-resistant S. aureus, AMRF1 (ST22) and AMRF2 (ST672), isolated from patients with ocular infections.

Characterization of genome in tetraploid StY species of Elymus (Triticeae: Poaceae) using sequential FISH and GISH.

Science.gov (United States)

Liu, Ruijuan; Wang, Richard R-C; Yu, Feng; Lu, Xingwang; Dou, Quanwen

2017-08-01

Genomes of ten species of Elymus, either presumed or known as tetraploid StY, were characterized using fluorescence in situ hybridization (FISH) and genomic in situ hybridization (GISH). These tetraploid species could be grouped into three categories. Type I included StY genome reported species-Roegneria pendulina, R. nutans, R. glaberrima, R. ciliaris, and Elymus nevskii, and StY genome presumed species-R. sinica, R. breviglumis, and R. dura, whose genome could be separated into two sets based on different GISH intensities. Type I genome constitution was deemed as putative StY. The St genome were mainly characterized with intense hybridization with pAs1, fewer AAG sites, and linked distribution of 5S rDNA and 18S-26S rDNA, while the Y genome with less intense hybridization with pAs1, more varied AAG sites, and isolated distribution of 5S rDNA and 18S-26S rDNA. Nevertheless, further genomic variations were detected among the different StY species. Type II included E. alashanicus, whose genome could be easily separated based on GISH pattern. FISH and GISH patterns suggested that E. alashanicus comprised a modified St genome and an unknown genome. Type III included E. longearistatus, whose genome could not be separated by GISH and was designated as St l Y l . Notably, a close relationship between S l and Y l genomes was observed.

78 FR 16211 - Safety Zone, Corp. Event Finale UHC, St. Thomas Harbor; St. Thomas, U.S. Virgin Islands

Science.gov (United States)

2013-03-14

... 1625-AA00 Safety Zone, Corp. Event Finale UHC, St. Thomas Harbor; St. Thomas, U.S. Virgin Islands... establish a temporary safety zone on the waters of St. Thomas Harbor in St. Thomas, U.S. Virgin Islands... through Friday, except federal holidays. The telephone number is 202-366-9329. See the ``Public...

78 FR 23489 - Safety Zone; V.I. Carnival Finale, St. Thomas Harbor; St. Thomas, U.S.V.I.

Science.gov (United States)

2013-04-19

... waters of St. Thomas Harbor in St. Thomas, U.S. Virgin Islands during the V.I. Carnival Finale, a... through Friday, except Federal holidays. FOR FURTHER INFORMATION CONTACT: If you have questions on this... event. The event will be held on the waters of St. Thomas Harbor, St. Thomas, U. S. Virgin Islands...

78 FR 22778 - Safety Zone; Corp. Event Finale UHC, St. Thomas Harbor; St. Thomas, U.S.V.I.

Science.gov (United States)

2013-04-17

... waters of St. Thomas Harbor in St. Thomas, U.S. Virgin Islands during the Corp. Event Finale UHC, a.... and 5 p.m., Monday through Friday, except Federal holidays. FOR FURTHER INFORMATION CONTACT: If you..., St. Thomas, U. S. Virgin Islands. The fireworks will be launched from a barge stationed near the St...

77 FR 59035 - Notice of Intent To Rule on Request To Release Airport Property at the St. George Airport, St...

Science.gov (United States)

2012-09-25

... To Release Airport Property at the St. George Airport, St. George, UT AGENCY: Federal Aviation... rule and invite public comment on the release of land at St. George Airport under the provisions of..., City of St. George, Utah, at the following address: Mr. Gary Esplin, City Manager, City of St. George...

78 FR 16208 - Safety Zone; V. I. Carnival Finale; St. Thomas Harbor; St. Thomas, U.S. Virgin Islands

Science.gov (United States)

2013-03-14

... 1625-AA00 Safety Zone; V. I. Carnival Finale; St. Thomas Harbor; St. Thomas, U.S. Virgin Islands AGENCY... establish a safety zone on the waters of St. Thomas Harbor in St. Thomas, U. S. Virgin Islands during the V... between 9 a.m. and 5 p.m., Monday through Friday, except federal holidays. The telephone number is 202-366...

St. Lucia.

Science.gov (United States)

1987-06-01

The population of St Lucia was 123,000 in 1986, with an annual growth rate of 2%. The infant mortality rate stands at 22.2/1000 live births, and life expectancy is 70.3 years for males and 74.9 years for females. The literacy rate is 78%. St Lucia's labor force is allocated as follows: agriculture, 36.6%; industry and commerce, 20.1%; and services, 18.1%. The gross national product (GNP) was US$146 million in 1985, with an annual growth rate of 3% and a per capita GNP of $1071. St Lucia is a parliamentary democracy modeled on the British Westminster system. The island is divided into 16 parishes and 1 urban area (the capital, Castries). St Lucia is currently a politically stable country, although the high level of youth unemployment is a cause for concern. Ongoing stability may depend on the government's ability to provide services such as jobs and housing. The economy has evolved from a monocrop sugar plantation type to a diversified economy based on agriculture, industry, and tourism. Agriculture, dominated by the banana industry, is characterized by the participation of a large number of small and medium-sized enterprises. Industry is being encouraged through the provision of incentives such as tax rebates. The government is attempting to maintain a sound investment climate through a tripartite dialogue with the private sector and trade unions. Overall economic policy is predicated on the attraction of sound investments, by both local and foreign entities, to accelerate the rate of economic growth, solve the unemployment problem, and generate a solid balance-of-payments position.

Fort St. Vrain circulator operating experience

International Nuclear Information System (INIS)

Brey, H.L.

1988-01-01

Fort St. Vrain, on the system of Public Service Company of Colorado, is the only high-temperature gas-cooled power reactor in the United States. Four helium circulators are utilized in this plant to transfer heat from the reactor to the steam generators. These unique machines have a single stage axial flow helium compressor driven by a single stage steam turbine. A single stage water driven (pelton wheel) turbine is the back-up drive utilizing either feed water, condensate, or fire water as the driving fluid. Developmental testing of the circulators was accomplished prior to installation into Fort St. Vrain. A combined machine operating history of approximately 250,000 hours has shown these machines to be of conservative design and proven mechanical integrity. However, many problems have been encountered in operating the complex auxiliaries which are necessary for successful circulator and plant operation. It has been 15 years since initial installation of the circulators occurred at Fort St. Vrain. During this time, a number of significant issues had to be resolved dealing specifically with machine performance. These events include cavitation damage of the pelton wheels during the initial plant hot functional testing, cracks in the water turbine buckets and cervic coupling, static shutdown seal bellows failure, and, most recently, degradation of components within the steam drive assembly. Unreliable operation particularly with the circulator auxiliaries has been a focus of attention by Public Service Company of Colorado. Actions to replace or significantly modify the existing circulators and their auxiliaries are currently awaiting decisions concerning the long-term future of the Fort St. Vrain plant. (author). 10 refs, 7 figs, 2 tabs

Fort St. Vrain circulator operating experience

Energy Technology Data Exchange (ETDEWEB)

Brey, H. L.

1988-08-15

Fort St. Vrain, on the system of Public Service Company of Colorado, is the only high-temperature gas-cooled power reactor in the United States. Four helium circulators are utilized in this plant to transfer heat from the reactor to the steam generators. These unique machines have a single stage axial flow helium compressor driven by a single stage steam turbine. A single stage water driven (pelton wheel) turbine is the back-up drive utilizing either feed water, condensate, or fire water as the driving fluid. Developmental testing of the circulators was accomplished prior to installation into Fort St. Vrain. A combined machine operating history of approximately 250,000 hours has shown these machines to be of conservative design and proven mechanical integrity. However, many problems have been encountered in operating the complex auxiliaries which are necessary for successful circulator and plant operation. It has been 15 years since initial installation of the circulators occurred at Fort St. Vrain. During this time, a number of significant issues had to be resolved dealing specifically with machine performance. These events include cavitation damage of the pelton wheels during the initial plant hot functional testing, cracks in the water turbine buckets and cervic coupling, static shutdown seal bellows failure, and, most recently, degradation of components within the steam drive assembly. Unreliable operation particularly with the circulator auxiliaries has been a focus of attention by Public Service Company of Colorado. Actions to replace or significantly modify the existing circulators and their auxiliaries are currently awaiting decisions concerning the long-term future of the Fort St. Vrain plant. (author). 10 refs, 7 figs, 2 tabs.

Development of HANARO ST3 shield

International Nuclear Information System (INIS)

Park, K. N.; Lee, J. S.; Shim, H. S.

2004-12-01

This report contains the design, fabrication and accurate installation of ST3 shield, which would be installed at ST3 beam port of HANARO. At first, we designed and fabricated ST3 shield casemate composed of 14 blocks. We filled it with heavy concrete, lead ingot and polyethylene that mixed B 4 C powder and epoxy. The average filling density of total shield casemate was 4.7g/cm 3 . The developed ST3 shield was installed at the ST3 beam port and the accuracy of installation for each beam path and channel was evaluated. We found that the extraction of neutron beam to meet the requirement of neutron spectrometer is possible. Also, we developed ancillary equipment such as BGU, quick shutter and exterior shield door for the effective opening and closing of neutron beam. As a result of this study, it was found that neutron spectrometer such as neutron reflectometer and high intensity powder diffractomater can be installed at the ST3 beam port

Seismic Stability of St. Stephen Hydropower Plant, South Carolina

National Research Council Canada - National Science Library

Ebeling, Robert M; Hall, Robert L; Strom, Ralph W; Yule, Donald E; Chowdhury, Mostafiz

2006-01-01

.... Two site-specific design response spectra were used to evaluate the structure. These included a 2,475-year probabilistic earthquake event and a deterministic Maximum Credible Earthquake plus one standard deviation event. The St...

Persist in creating of science and technology (S.T.), promote the development of uranium exploration

International Nuclear Information System (INIS)

Du Letian; Yu Dagan

2002-01-01

The modern social production is characterized by high-grade S.T. leading, the guarantee of which are the creating and recreating. Creating is comprehensive, including the thinking, concepts, view points, theories, systems, management, S.T., engineering, etc. The prospecting and exploration of uranium deposits in China also must follow this trend by renewing the strategies, the management system, S.T. studies, the thinking fashion for more, faster, better, finding uranium deposits

The emerging ST8 methicillin-resistant Staphylococcus aureus clone in the community in Japan: associated infections, genetic diversity, and comparative genomics.

Science.gov (United States)

Iwao, Yasuhisa; Ishii, Rumiko; Tomita, Yusuke; Shibuya, Yasuhiro; Takano, Tomomi; Hung, Wei-Chun; Higuchi, Wataru; Isobe, Hirokazu; Nishiyama, Akihito; Yano, Mio; Matsumoto, Tetsuya; Ogata, Kikuyo; Okubo, Takeshi; Khokhlova, Olga; Ho, Pak-Leung; Yamamoto, Tatsuo

2012-04-01

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has become a major concern worldwide. In the United States, ST8 CA-MRSA with SCCmecIVa (USA300) has been predominant, affecting the entire United States. In this study, we investigated Japanese ST8 CA-MRSA with new SCCmecIVl (designated ST8 CA-MRSA/J), which has emerged in Japan since 2003. Regarding community spread and infections, ST8 CA-MRSA/J spread in 16.2-34.4% as a major genotype in the community in Japan, and was associated with skin and soft tissue infections (SSTIs), colitis, and invasive infections (sepsis, epidural abscesses, and necrotizing pneumonia), including influenza prodrome cases and athlete infections, similar to USA300. It spread to even public transport and Hong Kong through a Japanese family. Regarding genetic diversity, ST8 CA-MRSA/J included ST and spa variants and was classified into at least three pulsed-field gel electrophoresis types, ST8 Jα to γ. Of those, ST8 Jβ was associated with severe invasive infections. As for genomics, ST8 CA-MRSA/J showed high similarities to USA300, but with marked diversity in accessory genes; e.g., ST8 CA-MRSA/J possessed enhanced cytolytic peptide genes of CA-MRSA, but lacked the Panton-Valentine leukocidin phage and arginine catabolic mobile element, unlike USA300. The unique features of ST8 CA-MRSA/J included a novel mosaic SaPI (designated SaPIj50) carrying the toxic shock syndrome toxin-1 gene with high expression; the evolution included salvage (through recombination) of hospital-acquired MRSA virulence. The data suggest that ST8 CA-MRSA/J has become a successful native clone in Japan, in association with not only SSTIs but also severe invasive infections (posing a threat), requiring attention.

Status of Design and Manufacturing of ITER 1st batch Assembly Tools

Energy Technology Data Exchange (ETDEWEB)

Bae, Jin Ho; Nam, Kyoun Go; Chung, Si Kun; Ha, Min Su [ITER Korea National Fusion Research Institute, Daejeon (Korea, Republic of); Kim, Geun Hong [ITER Organization, St Paul lez Durance (France)

2016-05-15

The ITER tokamak assembly tools are purpose-built and specially designed to complete the ITER tokamak machine which includes; Vacuum Vessel (VV), VV Thermal Shield (VVTS), Toroidal Field Coil (TFC) and other components contained in the cryostat. KODA has carried out the preliminary and final design of these assembly tools. This paper shows that the current status, first quarter of the 2016, including manufacturing of ITER 1st batch assembly tools and briefly summarized the design process through design work of Sector Sub-assembly Tool (SSAT) that is most important tool representing ITER 1st batch assembly tools. KODA (Korea Domestic Agency) should provide 128 kinds of the purpose-built assembly tools for ITER Tokamak machine, and the ITER 1st batch assembly tools are split into 3 groups. The FDR for Group A was performed in December 2014, and design of SSAT has been verified by FE analysis and engineering calculation using EN cords. The SSAT is now under manufacturing phase to meet the ITER milestone. After factory acceptance test of SSAT on end of 2016, the 1st SSAT will be delivered and arrived in ITER site on second quarter of the 2017.

mec-associated dru typing in the epidemiological analysis of ST239 MRSA in Malaysia.

Science.gov (United States)

Ghaznavi-Rad, E; Goering, R V; Nor Shamsudin, M; Weng, P L; Sekawi, Z; Tavakol, M; van Belkum, A; Neela, V

2011-11-01

The usefulness of mec-associated dru typing in the epidemiological analysis of methicillin-resistant Staphylococcus aureus (MRSA) isolated in Malaysia was investigated and compared with pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), and spa and SCCmec typing. The isolates studied included all MRSA types in Malaysia. Multilocus sequence type ST188 and ST1 isolates were highly clonal by all typing methods. However, the dru typing of ST239 isolates produced the clearest discrimination between SCCmec IIIa and III isolates, yielding more subtypes than any other method. Evaluation of the discriminatory power for each method identified dru typing and PFGE as the most discriminatory, with Simpson's index of diversity (SID) values over 89%, including an isolate which was non-typeable by spa, but dru-typed as dt13j. The discriminatory ability of dru typing, especially with closely related MRSA ST239 strains (e.g., Brazilian and Hungarian), underscores its utility as a tool for the epidemiological investigation of MRSA.

The role of SCUBE1 in the development of late stent thrombosis presenting with ST-elevation myocardial infarction.

Science.gov (United States)

Bolayır, Hasan Ata; Kıvrak, Tarık; Güneş, Hakan; Akaslan, Dursun; Şahin, Ömer; Bolayır, Aslı

2018-05-01

There is an important link between platelets and inflammation, thrombosis, and vascular and tissue repair mechanisms. SCUBE1 (signal peptide-CUB-EGF domain-containing protein 1) may function as a novel platelet-endothelial adhesion molecule and play pathological roles in cardiovascular biology. Stent thrombosis (ST) following percutaneous coronary intervention is an uncommon and potentially catastrophic event that can manifest as myocardial infarction and sudden death. High platelet reactivity is a risk factor for thrombotic events, including late ST. For this reason, in the current study, we researched the role of SCUBE1 in the development of late coronary ST. We included 40 patients admitted to our hospital with a diagnosis of ST-elevation myocardial infarction (STEMI) and signs of late ST on a coronary angiogram. For the control group, we recruited 50 healthy gender- and age-matched individuals who were seen for health check-ups. We also randomly included 100 patients with a diagnosis of STEMI without ST. There were no significant differences between the groups in terms of baseline and demographic characteristics. The mean SCUBE1 level in patients with STEMI with late ST at admission and the STEMI without ST group was significantly higher than in the control group (pST group was significantly higher than in the STEMI without ST group (p=0.03). In multivariate regression analysis, serum SCUBE1 (odds ratio [OR]: 1.022; 95% confidence interval [CI]: 1.011-1.033, pST. In addition, receiver operating characteristic curve analysis was used to determine the optimal SCUBE1 cut-off value for predicting late ST. The area under the curve was 0.972 (95% CI 0.95-0.98). The SCUBE1 cut-off value was 59.2 ng/ml, with a sensitivity of 95.4% and specificity of 82.9%. The present work is the first clinical study to demonstrate that serum SCUBE1 levels are significantly higher in patients with late ST and serum SCUBE1 was an independent predictor for the presence of late ST in our

Presence of selected chemicals of emerging concern in water and bottom sediment from the St. Louis River, St. Louis Bay, and Superior Bay, Minnesota and Wisconsin, 2010

Science.gov (United States)

Christensen, Victoria G.; Lee, Kathy E.; Kieta, Kristen A.; Elliott, Sarah M.

2012-01-01

The St. Louis Bay of Lake Superior receives substantial urban runoff, wastewater treatment plant effluent, and industrial effluent. In 1987, the International Joint Commission designated the St. Louis Bay portion of the lower St. Louis River as one of the Great Lakes Areas of Concern. Concerns exist about the potential effects of chemicals of emerging concern on aquatic biota because many of these chemicals, including endocrine active chemicals, have been shown to affect the endocrine systems of fish. To determine the occurrence of chemicals of emerging concern in the St. Louis River, the St. Louis Bay, and Superior Bay, the U.S. Geological Survey in cooperation with the Minnesota Pollution Control Agency and the Wisconsin Department of Natural Resources collected water and bottom-sediment samples from 40 sites from August through October 2010. The objectives of this study were to (1) identify the extent to which chemicals of emerging concern, including pharmaceuticals, hormones, and other organic chemicals, occur in the St. Louis River, St. Louis Bay, and Superior Bay, and (2) identify the extent to which the chemicals may have accumulated in bottom sediment of the study area. Samples were analyzed for selected wastewater indicators, hormones, sterols, bisphenol A, and human-health pharmaceuticals. During this study, 33 of 89 chemicals of emerging concern were detected among all water samples collected and 56 of 104 chemicals of emerging concern were detected in bottom-sediment samples. The chemical N,N-diethyl-meta-toluamide (DEET) was the most commonly detected chemical in water samples and 2,6-dimethylnaphthalene was the most commonly detected chemical in bottom-sediment samples. In general, chemicals of emerging concern were detected at a higher frequency in bottom-sediment samples than in water samples. Estrone (a steroid hormone) and hexahydrohexamethyl cyclopentabensopyran (a synthetic fragrance) were the most commonly detected endocrine active chemicals in

On the History of the Publication of the Menaion Reader by Demetrius of Rostov (the Text On the Year of Death of St. Mary of Egypt as an Additional Article to the Menaion Reader by St. Demetrius

Directory of Open Access Journals (Sweden)

Marina A. Fedotova

2015-08-01

The author of the present paper makes available a new, unknown, and unpublished work by St. Demetrius of Rostov, On the Year of Death of St. Mary of Egypt, which was written as an additional calendar text referring to the Life of St. Mary of Egypt. The sources of the Life of St. Mary of Egypt were the Acta Sanctorum and De Probatis Sanctorum Historiis by Laurentius Surius. The text On the Year of Death of St. Mary of Egypt was written by Demetrius for the first edition, but it was not included in the printed edition and is preserved only in manuscript sources.

Teknisk Ståbi

DEFF Research Database (Denmark)

Teknisk Ståbi er de bygningsprojekterendes og entreprenørers håndbog. Den dækker matematik, fysik, statestik, laster og sikkerhed samt beggematerialerne: beton, stål, træ, murværk, letbeton, glas og endelig fundering. Denne udgave er en næsten totalrevision, baseret på de nye Eurocodes, der afløs...

Land cover and forest formation distributions for St. Kitts, Nevis, St. Eustatius, Grenada and Barbados from decision tree classification of cloud-cleared satellite imagery. Caribbean Journal of Science. 44(2):175-198.

Science.gov (United States)

E.H. Helmer; T.A. Kennaway; D.H. Pedreros; M.L. Clark; H. Marcano-Vega; L.L. Tieszen; S.R. Schill; C.M.S. Carrington

2008-01-01

Satellite image-based mapping of tropical forests is vital to conservation planning. Standard methods for automated image classification, however, limit classification detail in complex tropical landscapes. In this study, we test an approach to Landsat image interpretation on four islands of the Lesser Antilles, including Grenada and St. Kitts, Nevis and St. Eustatius...

78 FR 45286 - Culturally Significant Objects Imported for Exhibition Determinations: “Canterbury and St. Albans...

Science.gov (United States)

2013-07-26

... DEPARTMENT OF STATE [Public Notice 8394] Culturally Significant Objects Imported for Exhibition Determinations: ``Canterbury and St. Albans: Treasures from Church and Cloister'' SUMMARY: Notice is hereby given... objects to be included in the exhibition ``Canterbury and St. Albans: Treasures from Church and Cloister...

The electrocardiographic "triangular QRS-ST-T waveform" pattern in patients with ST-segment elevation myocardial infarction: Incidence, pathophysiology and clinical implications.

Science.gov (United States)

Cipriani, Alberto; D'Amico, Gianpiero; Brunello, Giulia; Perazzolo Marra, Martina; Migliore, Federico; Cacciavillani, Luisa; Tarantini, Giuseppe; Bauce, Barbara; Iliceto, Sabino; Corrado, Domenico; Zorzi, Alessandro

A specific ECG pattern of presentation of ST-segment elevation acute myocardial infarction (STEMI), characterized by "triangular QRS-ST-T waveform" (TW), has been associated with poor in-hospital prognosis but longitudinal data on its incidence and clinical impact are lacking. We prospectively evaluated the incidence and prognostic meaning of the TW pattern in a cohort of consecutive STEMI patients. All STEMI patients who presented within 12h of symptoms onset and showed no complete bundle branch block or paced ventricular rhythm were included. The TW pattern was defined as a unique, giant wave (amplitude≥1mV) resulting from the fusion of the QRS complex, the ST-segment and the T-wave and showing a "triangular" morphology with a positive polarity in the leads exploring the ischemic region. Among 428 consecutive STEMI patients, 367 fulfilled the enrollment criteria. The TW pattern was identified in 5 of 367 patients (1.4%) on the admission ECG. This subset of STEMI patients with TW pattern significantly more often showed a left main coronary artery involvement (2/4, 50% vs 2/322, 0.6%; p<0.001), experienced ventricular fibrillation (5/5, 100% vs 35/362, 9.6% p<0.001), had cardiogenic shock (4/5, 80% vs. 14/362, 3.8%, p<0.001) and died during hospitalization (2/5, 40% vs 15/362, 4.1% p=0.02), compared with those with other ST-segment elevation ECG patterns. The TW pattern is an uncommon ECG finding, which reflects the presence of a large area of transmural myocardial ischemia and predicts cardiogenic shock accounting for high in-hospital mortality. When present, this ECG pattern should prompt aggressive therapeutic strategies, including mechanical support of circulation. Copyright © 2017 Elsevier Inc. All rights reserved.

Bimetal cup hydroforming of Al/St and Cu/St composites: Adaptive finite element analysis and experimental study

Energy Technology Data Exchange (ETDEWEB)

Hashemi, Abbas; Gollo, Mohammad Hoseinpour [Shahid Rajaee Teacher Training University, Tehran (Iran, Islamic Republic of); Seyedkashi, S. M. [University of Birjand, Birjand (Iran, Islamic Republic of)

2016-05-15

An adaptive Finite element analysis (FEA) was proposed in this paper for the industrial design of bimetal conical-cylindrical cup hydroforming. Forming circumstances for the perfect and imperfect parts were concluded through adaptive FEA using the ANSYS parametric design language. Effective parameters, including pressure loading path, layer placement order, and thickness ratio, were investigated for hydroforming of Al/St and Cu/St composite sheets. Experimental tests were implemented to validate adaptive finite element results. Rupture failure upon the pressure path occurred on the contact area between the blank and punch tip radius at low pressures and on the transition area of the conical-cylindrical portion at high pressures. The proposed method is applicable for any cylindrical, conical, or cylindrical/conical shapes with different materials and dimensions. Therefore, this method is beneficial as a practical design tool for engineers and researchers working in the process design of hydroformed shell products.

In Vitro Evaluation of Beneficial Properties of Bacteriocinogenic Lactobacillus plantarum ST8Sh.

Science.gov (United States)

Todorov, Svetoslav Dimitrov; Holzapfel, Wilhelm; Nero, Luis Augusto

2017-06-01

Lactobacillus plantarum ST8Sh, isolated from Bulgarian salami "shpek" and previously characterized as bacteriocin producer, was evaluated for its beneficial properties. Based on the PCR analysis, Lb. plantarum ST8Sh was shown to host a gene related to the production of adhesion proteins such as Mab, Mub, EF, and PrgB. Genetic and physiological tests suggest Lb. plantarum ST8Sh to represent a potential probiotic candidate, including survival in the presence of low levels of pH and high levels of ox bile, production of β-galactosidase, bile salt deconjugation, high level of hydrophobicity, functional auto- and co-aggregation properties, and adhesion to cell lines. Application of semi-purified bacteriocin produced by Lb. plantarum ST8Sh in combination with ciprofloxacin presented synergistic effect on inhibition of Listeria monocytogenes Scott A. Based on observed properties, Lb. plantarum ST8Sh can be considered as a potential probiotic candidate with additional bacteriocinogenic properties.

Promoter polymorphisms of ST3GAL4 and ST6GAL1 genes and associations with risk of premalignant and malignant lesions of the cervix.

Science.gov (United States)

Rivera-Juarez, Maria de Los Angeles; Rosas-Murrieta, Nora Hilda; Mendieta-Carmona, Victoriano; Hernandez-Pacheco, Raquel Esneidy; Zamora-Ginez, Irma; Rodea-Avila, Carlos; Apresa-Garcia, Teresa; Garay-Villar, Onix; Aguilar-Lemarroy, Adriana; Jave-Suarez, Luis Felipe; Diaz-Orea, Maria Alicia; Milflores-Flores, Lorena; Reyes-Salinas, Juan Salvador; Ceja-Utrera, Francisco Javier; Vazquez-Zamora, Victor Javier; Vargas-Maldonado, Tomas; Reyes-Carmona, Sandra; Sosa-Jurado, Francisca; Santos-Lopez, Gerardo; Reyes-Leyva, Julio; Vallejo-Ruiz, Veronica

2014-01-01

Sialyltransferase gene expression is altered in several cancers, including examples in the cervix. Transcriptional regulation of the responsible genes depends on different promoters. We aimed to determine the association of single-nucleotide polymorphisms in the B3 promoter of the ST3GAL4 gene and the P1 promoter of the ST6GAL1 gene with cervical premalignant lesions or cervical cancer. A blood sample and/or cervical scrapes were obtained from 104 women with normal cytology, 154 with premalignant lesions and 100 with cervical cancer. We also included 119 blood samples of random donors. The polymorphisms were identified by sequencing from PCR products. For the B3 promoter, a fragment of 506 bp (from nucleotide -408 to +98) was analyzed, and for the P1 promoter a 490 bp (-326 to +164) fragment. The polymorphism analysis showed that at SNP rs10893506, genotypes CC and CT of the ST3GAL4 B3 promoter were associated with the presence of premalignant lesions (OR=2.89; 95%CI 1.72-4.85) and cervical cancer (OR=2.23; 95%CI 1.27-3.91). We detected only one allele of each polymorphism in the ST6GAL1 P1 promoter. We did not detect any genetic variability in the P1 promoter region in our study population. Our results suggest that the rs10893506 polymorphism -22C/T may increase susceptibility to premalignant and malignant lesions of the cervix.

The marine Algal Vegetation of St. Martin, St. Eustatius and Saba (Netherlands Antilles)

NARCIS (Netherlands)

Vroman, M.

1968-01-01

Along the coast of St. Martin, St. Eustatius and Saba the rocks above sea-level often show a number of differently coloured zones. This is clearly visible when the coast over a larger distance is formed by one type of rock, as for instance on Saba. In many places a light-coloured belt is seen above

Soluble ST2 protein in the short-term prognosis after hospitalisation in chronic systolic heart failure.

Science.gov (United States)

Wojtczak-Soska, Karolina; Sakowicz, Agata; Pietrucha, Tadeusz; Lelonek, Małgorzata

2014-01-01

The prognosis in patients with chronic heart failure (CHF) is poor. ST2 protein is a promising prognostic biomarker for CHF. ST2 belongs to the cardioprotective signalling pathway involving interleukin-33 and its concentration in the serum depends on the biomechanical stress of cardiomyocytes (biomechanical strain). To determine the prognostic value of ST2 in short term follow-up after hospitalisation among patients with CHF. The study included 167 patients (mean age 62 years, 83% men) in stable NYHA class I-III with left ventricular ejection fraction (LVEF) of ≤ 45% (average 29.65%, ranges 13-45%). We analysed 58 variables including: demographics, co-morbidities, resting ECG, echocardiographic and coronary arteriography data, basic laboratory tests including N-terminal prohormone B-type natriuretic peptide (NT-proBNP), serum concentration of soluble form of ST2 (sST2) using quantitative ELISA test ST2 Kit (Medical and Biological Laboratories; Japan) and adverse cardiovascular events during a one year observation. In the study, the primary endpoint (death) and the composite endpoint (hospitalisation for HF worsening, worsening in NYHA functional class, the need to increase the dose of diuretics, and/or death in a one year observation) were determined. Patients who died (n = 24; 14.55%) were in more advanced NYHA class, had prolonged QRS duration, higher levels of sST2, NT-proBNP, and lower estimated glomerular filtration rate. From multivariate analysis, the independent variable for the primary endpoint was NT-proBNP (OR = 1.00012; 95% CI 1.00002-1.00022; p = 0.018). 93 (56%) patients reached the composite endpoint. Multivariate analysis revealed that fasting glucose (OR = 1.343; 95% CI 1.041-1.732; p = 0.023) and sST2 (OR = 3.593; 95% CI 1.427-9.05; p = 0.007) independently enhanced the risk of composite endpoint occurrence in a one year observation. In patients with CHF with LVEF ≤ 45%, the prognostic value of sST2 protein in a short-term observation of one

Lives Saved Tool (LiST) costing: a module to examine costs and prioritize interventions.

Science.gov (United States)

Bollinger, Lori A; Sanders, Rachel; Winfrey, William; Adesina, Adebiyi

2017-11-07

Achieving the Sustainable Development Goals will require careful allocation of resources in order to achieve the highest impact. The Lives Saved Tool (LiST) has been used widely to calculate the impact of maternal, neonatal and child health (MNCH) interventions for program planning and multi-country estimation in several Lancet Series commissions. As use of the LiST model increases, many have expressed a desire to cost interventions within the model, in order to support budgeting and prioritization of interventions by countries. A limited LiST costing module was introduced several years ago, but with gaps in cost types. Updates to inputs have now been added to make the module fully functional for a range of uses. This paper builds on previous work that developed an initial version of the LiST costing module to provide costs for MNCH interventions using an ingredients-based costing approach. Here, we update in 2016 the previous econometric estimates from 2013 with newly-available data and also include above-facility level costs such as program management. The updated econometric estimates inform percentages of intervention-level costs for some direct costs and indirect costs. These estimates add to existing values for direct cost requirements for items such as drugs and supplies and required provider time which were already available in LiST Costing. Results generated by the LiST costing module include costs for each intervention, as well as disaggregated costs by intervention including drug and supply costs, labor costs, other recurrent costs, capital costs, and above-service delivery costs. These results can be combined with mortality estimates to support prioritization of interventions by countries. The LiST costing module provides an option for countries to identify resource requirements for scaling up a maternal, neonatal, and child health program, and to examine the financial impact of different resource allocation strategies. It can be a useful tool for

Lives Saved Tool (LiST costing: a module to examine costs and prioritize interventions

Directory of Open Access Journals (Sweden)

Lori A. Bollinger

2017-11-01

Full Text Available Abstract Background Achieving the Sustainable Development Goals will require careful allocation of resources in order to achieve the highest impact. The Lives Saved Tool (LiST has been used widely to calculate the impact of maternal, neonatal and child health (MNCH interventions for program planning and multi-country estimation in several Lancet Series commissions. As use of the LiST model increases, many have expressed a desire to cost interventions within the model, in order to support budgeting and prioritization of interventions by countries. A limited LiST costing module was introduced several years ago, but with gaps in cost types. Updates to inputs have now been added to make the module fully functional for a range of uses. Methods This paper builds on previous work that developed an initial version of the LiST costing module to provide costs for MNCH interventions using an ingredients-based costing approach. Here, we update in 2016 the previous econometric estimates from 2013 with newly-available data and also include above-facility level costs such as program management. The updated econometric estimates inform percentages of intervention-level costs for some direct costs and indirect costs. These estimates add to existing values for direct cost requirements for items such as drugs and supplies and required provider time which were already available in LiST Costing. Results Results generated by the LiST costing module include costs for each intervention, as well as disaggregated costs by intervention including drug and supply costs, labor costs, other recurrent costs, capital costs, and above-service delivery costs. These results can be combined with mortality estimates to support prioritization of interventions by countries. Conclusions The LiST costing module provides an option for countries to identify resource requirements for scaling up a maternal, neonatal, and child health program, and to examine the financial impact of different

75 FR 38723 - Safety Zone; St. Ignace 4th of July Fireworks, East Moran Bay, Lake Huron, St. Ignace, MI

Science.gov (United States)

2010-07-06

...-AA00 Safety Zone; St. Ignace 4th of July Fireworks, East Moran Bay, Lake Huron, St. Ignace, MI AGENCY... safety zone on East Moran Bay, Lake Huron, St. Ignace, Michigan. This zone is intended to restrict vessels from a portion of East Moran Bay during the St. Ignace 4th of July Fireworks display, July 4, 2010...

Vegetation and Grazing in the St. Katherine Protectorate, South ...

African Journals Online (AJOL)

Plants were surveyed in the St. Katherine Protectorate of South Sinai, Egypt. The most frequently recorded plant species include: Artemisia herba-alba, Artemisia judaica, Fagonia arabica, Fagonia mollis, Schismus barbatus, Stachys aegyptiaca, Tanacetum sinaicum, Teucrium polium and Zilla spinosa. Dominant plant ...

The Role of the st313-td Gene in Virulence of Salmonella Typhimurium ST313

DEFF Research Database (Denmark)

Herrero-Fresno, Ana; Wallrodt, Inke; Leekitcharoenphon, Pimlapas

2014-01-01

Multidrug-resistant Salmonella enterica serovar Typhimurium ST313 has emerged in sub-Saharan Africa causing severe infections in humans. Therefore, it has been speculated that this specific sequence type, ST313, carries factors associated with increased pathogenicity. We assessed the role in viru...

ST-intuitionistic fuzzy metric space with properties

Science.gov (United States)

Arora, Sahil; Kumar, Tanuj

2017-07-01

In this paper, we define ST-intuitionistic fuzzy metric space and the notion of convergence and completeness properties of cauchy sequences is studied. Further, we prove some properties of ST-intuitionistic fuzzy metric space. Finally, we introduce the concept of symmetric ST Intuitionistic Fuzzy metric space.

Henkilöstövoimavarojen johtamista megamarketissa

OpenAIRE

Setälä, Minna

2016-01-01

Henkilöstö on lähes kaikkien organisaatioiden tärkein voimavara ja menestyksen perusta. Ilman henkilöstön olemassaoloa ja osaamista, ei mikään organisaatio pystyisi toimimaan. Henkilöstövoimavarojen johtamisen tulisikin olla keskeinen osa yrityksen strategista toimintaa. Osaava ja hyvinvoiva henkilöstö tuottaa luonnollisesti vastinetta siihen sijoitetulle pääomalle. Tämä opinnäytetyö tehtiin Vantaalla sijaitsevalle elintarvike- ja päivittäistavaraketjun myymälälle, supermarketille. Tavo...

Herrens röst

DEFF Research Database (Denmark)

Rösing, Lilian Munk

2015-01-01

Om språket är gränsen mellan djur och människor, vad innebär det när hundar talar? I filmen Upp pratar de animerade hundarna, men med sin husses röst. Lilian Munk Rösing ser filmen i sällskap av bland andra Jacques Lacan, Slavoj Žižek och Renata Salecl och finner en röst utan kropp, en kropp besj...

78 FR 53247 - Approval and Promulgation of Implementation Plans; State of Missouri; St. Louis Area...

Science.gov (United States)

2013-08-29

... include amendments to sections (1) through (4) of rule 10 CSR 10-5.480 St. Louis Area Transportation... approving the State's request to amend 10 CSR 10-5.480 St. Louis Area Transportation Conformity Requirements... action'' subject to review by the Office of Management and Budget under Executive Order 12866 (58 FR...

Smart Social Networking: 21st Century Teaching and Learning Skills

Directory of Open Access Journals (Sweden)

Helen B. Boholano

2017-06-01

Full Text Available Education in the 21st century highlights globalization and internationalization. Preservice teachers in the 21st century are technology savvy. To effectively engage and teach generation Z students, preservice teachers will help the educational system meet this requirement. The educational systems must be outfitted with a prerequisite of ICT resources both hardware and software, and curricula must be designed to promote a collaborative learner-centered environment to which students will relate and respond. This study determines the 21st century skills possessed by the pre-service teachers in terms of social networking. Pre-service teachers use computers in very advanced ways, but educators must remember that they still need guidance to use technology safely and effectively. Through social media the pre-service teachers can use a multitude of applications, including Web 2.0, for their projects. Smart social networking requires critical-thinking skills and the ability to integrate and evaluate real-world scenarios and authentic learning skills for validation.

St. James marine terminal facility description

Energy Technology Data Exchange (ETDEWEB)

1993-10-01

The US Department of Energy (DOE) currently owns and operates a marine terminal on the west bank of the Mississippi River at St. James, Louisiana. The St. James facility was constructed by the Department to provide marine services associated with the fill and drawdown of the Strategic Petroleum Reserve (SPR) crude oil storage facilities located at Bayou Choctaw and Weeks Island, Louisiana. Although strategic to the mission of the SPR in the event of a national emergency, the St. James terminal is situated such that it has a high potential to also serve the commercial industry`s needs for crude oil terminalling and storage. The St. James terminal is located approximately 45 miles west of New Orleans and 30 miles southeast of Baton Rouge, and approximately 160 miles upstream from the mouth of the Mississippi River. Construction of the St. James terminal was initiated in 1978 and was completed in 1980. Since then, the terminal has received and transferred over 125 million barrels of crude oil to the SPR sites for storage. For crude oil distribution, the St. James terminal was connected to the neighboring LOCAP terminal by a 0.1 mile 36-inch pipeline in 1981 and to the Capline terminal by a 0.5 mile 30-inch pipeline in 1988. The terminal also has a 30-inch pipeline connection to the Koch oil terminal which was used for initial fill purposes; however, this pipeline has been disconnected and is currently inactive. A complete description of the St. James terminal facilities, operational capabilities, operational certifications, and future Government requirements are presented in Sections 2, 3, 4, and 5 respectively.

Resources for Economic Educators from the Federal Reserve Bank of St. Louis

Science.gov (United States)

Suiter, Mary C.; Taylor, Keith G.

2016-01-01

The Federal Reserve Bank of St. Louis has a long history of providing economic and financial information to the public that continues today, although the format, delivery, and amount of information have changed over the years. Today, the St. Louis Fed provides Web-based data and information services, including FRED® and FRASER®, and publications,…

Meteor detection on ST (MST) radars

International Nuclear Information System (INIS)

Avery, S.K.

1987-01-01

The ability to detect radar echoes from backscatter due to turbulent irregularities of the radio refractive index in the clear atmosphere has lead to an increasing number of established mesosphere - stratosphere - troposphere (MST or ST) radars. Humidity and temperature variations are responsible for the echo in the troposphere and stratosphere and turbulence acting on electron density gradients provides the echo in the mesosphere. The MST radar and its smaller version, the ST radar, are pulsed Doppler radars operating in the VHF - UHF frequency range. These echoes can be used to determine upper atmosphere winds at little extra cost to the ST radar configuration. In addition, the meteor echoes can supplement mesospheric data from an MST radar. The detection techniques required on the ST radar for delineating meteor echo returns are described

Stereospecificity (ST) of the microsomal ethanol oxidizing system (MEOS)

International Nuclear Information System (INIS)

Alderman, J.; Kato, S.; Lasker, J.; Lieber, C.S.

1987-01-01

The ST of MEOS for the ethanol 1R hydrogen has been variously reported as absolute, partial or absent, with free radical involvement postulated in the latter case. To determine both the ST of MEOS and the participation of free radicals in the reaction, they investigated MEOS ST using 1R[1- 3 H] ethanol as substrate. ST is expressed as the fraction of 3 H labeling in acetaldehyde formed, relative to that in ethanol, and ranges from 0.5 to 0. Partial ST was observed using liver microsomes from both rats and hamsters; it significantly decreased after ethanol feeding. 0.1 mM desferrioxamine (dfx) did not increase ST in any of these microsomal preparations while ferric EDTA decreased it, suggesting that ethanol treatment induces a cytochrome P-450 with lower ST rather than increasing free radical involvement. This is supported by a virtual absence of ST observed in a reconstituted system containing purified hamster P-450/sub ALC/, a liver cytochrome P-450 isozyme induced in hamsters by ethanol treatment. Their results indicate that, unlike other enzymes that oxidize ethanol, MEOS has only partial ST. Thus, ST alone cannot be used as an index of free radical involvement but, when evaluated with the response of ST to dfx, it indicated that MEOS is unlikely to involve free radical attack on ethanol in solution

Nuclear regulatory legislation, 101st Congress

International Nuclear Information System (INIS)

1991-06-01

This document is a compilation of nuclear regulatory legislation and other relevant material through the 101st Congress, 2nd Session. This compilation has been prepared for use as a resource document, which the NRC intends to update at the end of every Congress. The contents of NUREG-0980 include The Atomic Energy Act of 1954, as amended: Energy Reorganization Act of 1974, as amended; Uranium Mill Tailings Radiation Control Act of 1978; Low-Level Radioactive Waste Policy Act; Nuclear Waste Policy Act of 1982; and NRC Authorization and Appropriations Acts. Other materials included are statues and treaties on export licensing, nuclear non-proliferation, and environmental protection

Reciprocal ST-Segment Changes in Myocardial Infarction: Ischemia at Distance Versus Mirror Reflection of ST-Elevation.

Science.gov (United States)

Vaidya, Gaurang Nandkishor; Antoine, Steve; Imam, Syed Haider; Kozman, Hani; Smulyan, Harold; Villarreal, Daniel

2018-02-01

Reciprocal ST-depression in the electrocardiograms (ECGs) of patients with ST-elevation myocardial infarction (STEMI) results from either true ischemia at a distance via collateral circulation diverting blood to the infarcted region or an electrical phenomenon that results from a mirror reflection of ST-elevation. We aimed to identify the role of reciprocal ECG changes in predicting collateral circulation to the infarcted area determined angiographically. In a retrospective study, ECG and angiography of 53 STEMI patients admitted to SUNY Upstate Medical University in 2014 were reviewed independently by experts blinded to the results of ECG and coronary angiography. Reciprocal changes (RC) in ECG were present in 41 patients (77%) and on angiography, 14 patients (26%) exhibited collateral vessels to the ischemic areas. No correlation was found between the presence of RC and collateral circulation (P = 0.384), or between the depth of reciprocal ST-depression and the degree of the collateral circulation (P = 0.195). However, 84% of patients without collaterals exhibited resolution of RC after successful percutaneous coronary intervention (PCI) (P = 0.036), suggesting that the ST depressions that resolved after reperfusion were directly caused by the culprit vessel. Patients without RC presented late after symptom onset (9.25 versus 3.83 hours, P = 0.004), also suggesting time related resolution. RC had no relation to or predictive value for collaterals on angiography. Among late presenting patients, RC were less frequent. Thus, reciprocal ST-depression may represent subendocardial ischemia from the primary coronary event or simply an electrical phenomenon, rather than ischemia at distance from impaired collateral circulation. Published by Elsevier Inc.

Firmaets Største Bedrift

DEFF Research Database (Denmark)

Hansen, Peer Henrik

fortæller, hvordan de tidligere modstandsfolk Arne Sejr og Niels Frommelt få år efter befrielsen etablerede deres såkaldte Firma for med støtte fra ledende danske politikere, Forsvarets Efterretningstjeneste og CIA at organisere en hemmelig krig mod Sovjetunionens danske støtter. Meget tyder på, at både...

St. Louis Area Earthquake Hazards Mapping Project - A Progress Report-November 2008

Science.gov (United States)

Karadeniz, D.; Rogers, J.D.; Williams, R.A.; Cramer, C.H.; Bauer, R.A.; Hoffman, D.; Chung, J.; Hempen, G.L.; Steckel, P.H.; Boyd, O.L.; Watkins, C.M.; McCallister, N.S.; Schweig, E.

2009-01-01

St. Louis has experienced minor earthquake damage at least 12 times in the past 200 years. Because of this history and its proximity to known active earthquake zones, the St. Louis Area Earthquake Hazards Mapping Project (SLAEHMP) is producing digital maps that show variability of earthquake hazards, including liquefaction and ground shaking, in the St. Louis area. The maps will be available free via the internet. Although not site specific enough to indicate the hazard at a house-by-house resolution, they can be customized by the user to show specific areas of interest, such as neighborhoods or transportation routes. Earthquakes currently cannot be predicted, but scientists can estimate how strongly the ground is likely to shake as the result of an earthquake. Earthquake hazard maps provide one way of conveying such estimates. The U.S. Geological Survey (USGS), which produces earthquake hazard maps for the Nation, is working with local partners to develop detailed maps for urban areas vulnerable to strong ground shaking. These partners, which along with the USGS comprise the SLAEHMP, include the Missouri University of Science and Technology-Rolla (Missouri S&T), Missouri Department of Natural Resources (MDNR), Illinois State Geological Survey (ISGS), Saint Louis University, Missouri State Emergency Management Agency, and URS Corporation. Preliminary hazard maps covering a test portion of the 29-quadrangle St. Louis study area have been produced and are currently being evaluated by the SLAEHMP. A USGS Fact Sheet summarizing this project was produced and almost 1000 copies have been distributed at several public outreach meetings and field trips that have featured the SLAEHMP (Williams and others, 2007). In addition, a USGS website focusing on the SLAEHMP, which provides links to project results and relevant earthquake hazard information, can be found at: http://earthquake.usgs.gov/regional/ceus/urban_map/st_louis/index.php. This progress report summarizes the

Hydrologic data summary for the St. Lucie River Estuary, Martin and St. Lucie Counties, Florida, 1998-2001

Science.gov (United States)

Byrne, Michael J.; Patino, Eduardo

2004-01-01

A hydrologic analysis was made at three canal sites and four tidal sites along the St. Lucie River Estuary in southeastern Florida from 1998 to 2001. The data included for analysis are stage, 15-minute flow, salinity, water temperature, turbidity, and suspended-solids concentration. During the period of record, the estuary experienced a drought, major storm events, and high-water discharge from Lake Okeechobee. Flow mainly occurred through the South Fork of the St. Lucie River; however, when flow increased through control structures along the C-23 and C-24 Canals, the North Fork was a larger than usual contributor of total freshwater inflow to the estuary. At one tidal site (Steele Point), the majority of flow was southward toward the St. Lucie Inlet; at a second tidal site (Indian River Bridge), the majority of flow was northward into the Indian River Lagoon. Large-volume stormwater discharge events greatly affected the St. Lucie River Estuary. Increased discharge typically was accompanied by salinity decreases that resulted in water becoming and remaining fresh throughout the estuary until the discharge events ended. Salinity in the estuary usually returned to prestorm levels within a few days after the events. Turbidity decreased and salinity began to increase almost immediately when the gates at the control structures closed. Salinity ranged from less than 1 to greater than 35 parts per thousand during the period of record (1998-2001), and typically varied by several parts per thousand during a tidal cycle. Suspended-solids concentrations were observed at one canal site (S-80) and two tidal sites (Speedy Point and Steele Point) during a discharge event in April and May 2000. Results suggest that most deposition of suspended-solids concentration occurs between S-80 and Speedy Point. The turbidity data collected also support this interpretation. The ratio of inorganic to organic suspended-solids concentration observed at S-80, Speedy Point, and Steele Point

Escherichia coli ST131, an Intriguing Clonal Group

Science.gov (United States)

Bertrand, Xavier; Madec, Jean-Yves

2014-01-01

SUMMARY In 2008, a previously unknown Escherichia coli clonal group, sequence type 131 (ST131), was identified on three continents. Today, ST131 is the predominant E. coli lineage among extraintestinal pathogenic E. coli (ExPEC) isolates worldwide. Retrospective studies have suggested that it may originally have risen to prominence as early as 2003. Unlike other classical group B2 ExPEC isolates, ST131 isolates are commonly reported to produce extended-spectrum β-lactamases, such as CTX-M-15, and almost all are resistant to fluoroquinolones. Moreover, ST131 E. coli isolates are considered to be truly pathogenic, due to the spectrum of infections they cause in both community and hospital settings and the large number of virulence-associated genes they contain. ST131 isolates therefore seem to contradict the widely held view that high levels of antimicrobial resistance are necessarily associated with a fitness cost leading to a decrease in pathogenesis. Six years after the first description of E. coli ST131, this review outlines the principal traits of ST131 clonal group isolates, based on the growing body of published data, and highlights what is currently known and what we need to find out to provide public health authorities with better information to help combat ST131. PMID:24982321

Role of myocardial ischemia on exercise-induced ST elevation

International Nuclear Information System (INIS)

Saito, Muneyasu; Sumiyoshi, Tetsuya; Nishimura, Tsunehiko; Uehara, Toshiisa; Hayashida, Kouhei; Haze, Kazuo; Fukami, Ken-ichi; Hiramori, Katsuhiko

1986-01-01

Exercise-induced ST elevation in patients with previous myocardial infarction (MI) has been recognized to be related to left ventricular (LV) asynergy, however it is also recognized that myocardial ischemia can induce ST elevation. In this study, factors which determine the extent of ST elevation, with special reference to myocardial ischemia, was re-evaluated using quantitative analysis of stress myocardial scintigraphy (S-SG). Among 65 patients with previous anterior myocardial infarction and documented single vessel disease of left anterior descending artery (LAD), 19 patients who had exercise-induced ST elevation (ΔST ≥ 2.0 mm) had more abnormal Q waves (p < 0.01), lower LV ejection fraction (EF) (p < 0.01), more severe LV asynergy (p < 0.05) and less incidence of post-MI angina pectoris (AP) (p < 0.01), compared to those with ΔST < 2.0 mm, indicating that ST elevation is primarily related to LV asynergy. Correlation studies among clinical, angiographic and scintigraphic parameters show that ΔST was significantly related to a size of MI represented by Tl score or relative defect Tl activity and number of abnormal Q waves (No.Q), the magnitude of work load expressed by changes in double product (ΔDP) and intervals between the onset and exercise test, as well as myocardial ischemia expressed by the extent of redistribution (%RD) in S-SG. Among 23 patients with post-MI AP, ΔST significantly correlated with %RD (r = 0.47), indicating that myocardial ischemia can be a mechanism of exercise-induced ST elevation in patients with previous MI. Furtheremore, among those with ST elevation, concave-type ST elevation was more related to myocardial ischemia compared to convex-type ST elevation as expressed by the incidence of post-MI AP and/or significant redistribution. (J.P.N.)

Non-ST Elevation Myocardial Infraction after High Dose Intravenous Immunoglobulin Infusion

Directory of Open Access Journals (Sweden)

Meir Mizrahi

2009-01-01

Full Text Available Intravenous immunoglobulins (IVIgs are used for several indications, including autoimmune conditions. IVIg treatment is associated with several possible adverse reactions including induction of a hypercoagulable state. We report a 76-year-old woman treated with IVIg for myasthenia gravis, which developed chest pain and weakness following IVIg infusion. The symptoms were associated with ST segment depression in V4–6 and elevated troponin levels. The patient was diagnosed with non-ST elevation myocardial infarction (NSTEMI. The patient had no significant risk factor besides age and a cardiac perfusion scan was interpreted as normal (the patient refused to undergo cardiac catheterization. This case is compatible with IVIg-induced hypercoagulability resulting in NSTEMI. Cardiac evaluation should therefore be considered prior to initiation of IVIg treatment especially in patients with multiple cardiovascular risks.

Birds of the St. Croix River valley: Minnesota and Wisconsin

Science.gov (United States)

Faanes, Craig A.

1981-01-01

The St. Croix River Valley encompasses nearly 11,550 km2 in east-central Minnesota and northwestern Wisconsin. A wide range of habitats are available for birds including upland oak, lowland deciduous, maple-basswood, lowland and upland coniferous forests, natural basin wetlands, and grasslands. Situated in the north-central region of the United States, the valley is a biological 'crossroads' for many species. Because of the mixed affinities of plant communities, the valley includes the northern and southern range limits for a number of species. Also, because the valley lies near the forest-prairie transition zone, many typical western breeding species (e.g. pintail, western meadowlark, yellow-headed blackbird) breed in proximity to typical eastern species such as tufted titmouse, eastern meadowlark, and cardinal. From 1966 to 1980, I conducted extensive surveys of avian distribution and abundance in the St. Croix River Valley. I have supplemented the results of these surveys with published and unpublished observations contributed by many ornithologists. These additional data include compilations from Christmas Bird Counts sponsored by the National Audubon Society and from the Breeding Bird Survey coordinated by the U.S. Fish and Wildlife Service. Three hundred fourteen species have been recorded in the study area; data are presented on the migration period, nesting season distribution, winter distribution, relative abundance, and habitat use of each species. Recognizing the uniqueness of the area, and its importance not only to wildlife but also to man, the U.S. Congress designated the St. Croix a National Scenic Riverway. This action provided a considerable degree of protection to lands along and directly adjacent to the river. Unfortunately, no similar legal measure exists to protect lands away from the river. With the exception of the northern quarter of the St. Croix River Valley, agricultural interests have made significant inroads into the habitat base. The

Emergence in Taiwan of novel imipenem-resistant Acinetobacter baumannii ST455 causing bloodstream infection in critical patients.

Science.gov (United States)

Lee, Hao-Yuan; Huang, Chih-Wei; Chen, Chyi-Liang; Wang, Yi-Hsin; Chang, Chee-Jen; Chiu, Cheng-Hsun

2015-12-01

Acinetobacter baumannii is one of the most important nosocomial pathogens worldwide. This study aimed to use multilocus sequence typing (MLST) for the epidemiological surveillance of A. baumannii isolates in Taiwan and analyze the clinical presentations and patients' outcome. MLST according to both Bartual's PubMLST and Pasteur's MLST schemes was applied to characterize bloodstream imipenem-resistant A. baumannii (IRAB) infection in intensive care units in a medical center. A total of 39 clinical IRAB bloodstream isolates in 2010 were enrolled. We also collected 13 imipenem-susceptible A. baumannii (ISAB) bloodstream isolates and 30 clinical sputum isolates (24 IRAB and 6 ISAB) for comparison. Clinical presentations and outcome of the patients were analyzed. We found that infection by ST455(B)/ST2(P) and inappropriate initial therapy were statistically significant risk factors for mortality. More than one-third of the IRAB isolates belonged to ST455(B)/ST2(P). Most ST455(B)/ST2(P) (80%) carried ISAba1-blaOXA-23, including 10 (66.7%) with Tn2006 (ISAba1-blaOXA-23-ISAba1) in an AbaR4-type resistance island. ST455(B)/ST2(P) appears to evolve from ST208(B)/ST2(P) of clonal complex (CC) 92(B)/CC2(P). In this hospital-based study, A. baumannii ST455 accounted for 38.5% of IRAB bacteremia, with a high mortality of 86.7%. Approximately 85% of ST455(B)/ST2(P)bacteremia had a primary source of ventilation-associated pneumonia. We report the emergence in Taiwan of IRAB ST455(B)/ST2(P), which is the current predominant clone of IRAB in our hospital and has been causing bacteremia with high mortality in critical patients. Copyright © 2015. Published by Elsevier B.V.

Outbreak by Hypermucoviscous Klebsiella pneumoniae ST11 Isolates with Carbapenem Resistance in a Tertiary Hospital in China

Directory of Open Access Journals (Sweden)

Lingling Zhan

2017-05-01

Full Text Available Hypervirulent and multidrug resistant Klebsiella pneumoniae strains pose a significant threat to the public health. In the present study, 21 carbapenem-resistant K. pneumoniae isolates (CRKP were determined by the string test as hypermucoviscous K. pneumoniae (HMKP, with the prevalence of 15.0% (21/140 among CRKP, and 1.1% (21/1838 among all K. pneumoniae isolates. Among them, 7 (33.3%, and 1 (4.76% isolate belonged to capsular serotype K20 and K2 respectively, while 13 (61.9%, 13/21 weren't successfully typed by capsular serotyping. All the 21 isolates were carbapenemase-producers and were positive for blaKPC-2. In addition to blaKPC-2, all the 21 isolates except one harbor blaSHV-11, and 15 carry extended-spectrum β-lactamase gene blaCTX-M-65. The virulence-associated genes with more than 90% of positive rates among 21 isolates included ureA (100%, 21/21, wabG (100%, 21/21, fimH (95.2%, 20/21, entB (95.2%, 20/21, ycf (95.2%, 20/21, ybtS (95.2%, 20/21, and iutA (90.5%, 19/21. rmpA and aerobactin were found in 57.1% (12/21 isolates. Five sequence types (STs were identified by multilocus sequence typing (MLST, including ST11 (11 K-non capsule typable and 5 K20 isolates, ST268 (1 K20 isolate and 1 K-non capsule typable isolate, ST65 (1 K2 isolate, ST692 (1 K-non capsule typable isolate, and ST595, a novel sequence type (1 K-non capsule typable isolate. Pulsed-field gel electrophoresis (PFGE results showed two major PFGE clusters, of which cluster A accounts for 6 ST11 isolates (28.6% and cluster B includes 8 ST11 isolates (38.1%, 8/21. Ten and six ST11 isolates were isolated from 2014 and 2015, respectively, while 8 were isolated from the same month of December in 2014. Ten isolates were collected from the intensive care unit (ICU, and all except one belonged to ST11. Additional 4 ST11 isolates were collected from patients in non-ICU wards, who had more than 10 days of ICU stay history in 2014 prior to transfer to their current wards where the

21st Century Skills Map: Geography

Science.gov (United States)

Partnership for 21st Century Skills, 2009

2009-01-01

This 21st Century Skills Map is the result of hundreds of hours of research, development and feedback from educators and business leaders across the nation. The Partnership for 21st Century Skills has issued this map for the core subject of Geography.

The cognitive status of stød

DEFF Research Database (Denmark)

Clausen, Sara Juul; Kristensen, Line Burholt

2015-01-01

marked. Keeping in mind the cross-distribution between phonetic/phonological markedness and distributional patterns, we investigate here whether stød is also related to accent 1 when it comes to cognitive markedness. We present the results of a psycholinguistic study in which participants attended...... for words with non-stød stems, indicating that the cognitive markedness status of stød corresponds to that of accent 2....

The GEOSS Science and Technology Stakeholder Network and Service Suite: Linking S&T Communities and GEOSS

Science.gov (United States)

Plag, Hans-Peter; Jules-Plag, Shelley

2015-04-01

The Global Earth Observation System of Systems (GEOSS) developed by the Group on Earth Observations (GEO) aims to provide practice-relevant knowledge in support of decision making in a wide range of societal benefit areas. Generating this practice-relevant knowledge based on Earth observations, socio-economic data and models often depends on research, and utilization of the societal benefits of EOs requires the involvement of science and research communities. Building a GEOSS responding to the needs of a wide range of users necessitates contributions from many science and technology (S&T) communities. In particular, a strong engagement of science and technology (S&T) communities in both the development and use of GEOSS is necessary to address the complex issues associated with the on-going transition out of the Holocene. S&T support is needed to improve interoperability between global observing, modeling, and information systems; to enable data integration across disciplinary boundaries; to facilitate data sharing, archiving, dissemination, and reanalysis; to optimize the recording of observations, assimilation of data into models, and generation of data products; to enhance the value of observations from individual observing systems through their integration in the SBAs; and to harmonize well-calibrated, highly accurate, stable, sustained in-situ and satellite observations of the same variable recorded by different sensors and different agencies. Consequently, the GEO Work Plan includes several Tasks focusing on outreach to S&T communities, and most of the GEO Community of Practice have a strong S&T component. The GEOSS S&T Stakeholder Network facilitates input from S&T communities to GEO. Infrastructure serving and linking S&T users communities and GEOSS has been developed and is integrated into a GEOSS S&T Service Suite (GSTSS). The GSTSS has several outreach components for the demonstration of GEOSS and its value for S&T communities, and for services supporting

Spot Støjbergs støj

DEFF Research Database (Denmark)

Kock, Christian Erik J

2015-01-01

Inger Støjberg er placeret på en af de mest profilerede poster i Løkkes regering. Spørger du hende om fortiden, taler hun om fremtiden. Spørger du hende om fremtiden, taler hun om fortiden. Ergo: Hun taler udenom, og hun er god til det. Hun er så god, at det skader demokratiet. Lær at spotte hend...

Chicago-St. Louis high speed rail plan

International Nuclear Information System (INIS)

Stead, M.E.

1994-01-01

The Illinois Department of Transportation (IDOT), in cooperation with Amtrak, undertook the Chicago-St. Louis High Speed Rail Financial and Implementation Plan study in order to develop a realistic and achievable blueprint for implementation of high speed rail in the Chicago-St. Louis corridor. This report presents a summary of the Price Waterhouse Project Team's analysis and the Financial and Implementation Plan for implementing high speed rail service in the Chicago-St. Louis corridor

Chicago-St. Louis high speed rail plan

Energy Technology Data Exchange (ETDEWEB)

Stead, M.E.

1994-12-31

The Illinois Department of Transportation (IDOT), in cooperation with Amtrak, undertook the Chicago-St. Louis High Speed Rail Financial and Implementation Plan study in order to develop a realistic and achievable blueprint for implementation of high speed rail in the Chicago-St. Louis corridor. This report presents a summary of the Price Waterhouse Project Team`s analysis and the Financial and Implementation Plan for implementing high speed rail service in the Chicago-St. Louis corridor.

Data Abstraction Mechanisms in Sina/st

NARCIS (Netherlands)

Meyrowitz, N.K.; Aksit, Mehmet; Tripathi, Anand

1988-01-01

This paper describes a new data abstraction mechanism in an object-oriented model of computing. The data abstraction mechanism described here has been devised in the context of the design of Sina/st language. In Sina/st no language constructs have been adopted for specifying inheritance or

Automated system for ST segment and arrhythmia analysis in exercise radionuclide ventriculography

International Nuclear Information System (INIS)

Hsia, P.W.; Jenkins, J.M.; Shimoni, Y.; Gage, K.P.; Santinga, J.T.; Pitt, B.

1986-01-01

A computer-based system for interpretation of the electrocardiogram (ECG) in the diagnosis of arrhythmia and ST segment abnormality in an exercise system is presented. The system was designed for inclusion in a gamma camera so the ECG diagnosis could be combined with the diagnostic capability of radionuclide ventriculography. Digitized data are analyzed in a beat-by-beat mode and a contextual diagnosis of underlying rhythm is provided. Each beat is assigned a beat code based on a combination of waveform analysis and RR interval measurement. The waveform analysis employs a new correlation coefficient formula which corrects for baseline wander. Selective signal averaging, in which only normal beats are included, is done for an improved signal-to-noise ratio prior to ST segment analysis. Template generation, R wave detection, QRS window size, baseline correction, and continuous updating of heart rate have all been automated. ST level and slope measurements are computed on signal-averaged data. Arrhythmia analysis of 13 passages of abnormal rhythm by computer was found to be correct in 98.4 percent of all beats. 25 passages of exercise data, 1-5 min in length, were evaluated by the cardiologist and found to be in agreement in 95.8 percent in measurements of ST level and 91.7 percent in measurements of ST slope

Acute Carbon Monoxide Poisoning Resulting in ST Elevation Myocardial Infarction: A Rare Case Report

Directory of Open Access Journals (Sweden)

Po-Chao Hsu

2010-05-01

Full Text Available Acute carbon monoxide (CO poisoning with cardiac complications is well documented in the literature. However, ST segment elevation is a rare presentation, and most of these cases with ST elevation have revealed non-occlusive or normal coronary arteries. We report a case of CO poisoning complicated with ST elevation myocardial infarction. Emergency coronary angiography revealed total occlusion of the left anterior descending artery and primary percutaneous coronary intervention was performed. This report of a rare case should remind physicians that cardiovascular investigations, including electrocardiography, must be performed in cases with CO poisoning because mortality might increase if reperfusion therapy or appropriate medical treatments are not performed in patients with acute coronary artery occlusion.

Myocarditis with ST elevation and elevated cardiac enzymes misdiagnosed as an ST-elevation myocardial infarction.

Science.gov (United States)

Sheldon, Seth H; Crandall, Mark A; Jaffe, Allan S

2012-12-01

Acute myocarditis can mimic ST-elevation myocardial infarction (STEMI). Quickly determining the correct diagnosis is critical given the "time is muscle" implication with a STEMI and the potential adverse effects associated with use of fibrinolytic therapy. A 46-year-old man presented to a rural emergency department with chest pain, and an electrocardiogram (ECG) read as showing 0.1 mV of ST-segment elevation in leads III and aVF. His initial cardiac troponin T was 0.44 ng/mL. He received fibrinolytic therapy for presumed STEMI. Cardiac magnetic resonance imaging was later performed and showed epicardial delayed enhancement consistent with myocarditis. Upon further questioning, he acknowledged 3 days of stuttering chest discomfort and a recent upper respiratory infection, as well as similar chest pain in his wife. A systematic evaluation is essential for acute chest pain, including a focused history, identification of cardiac risk factors, and ECG interpretation. A history of recent viral illness, absence of cardiac risk factors, or ECG findings inconsistent with a single anatomic lesion would suggest a potential alternate diagnosis to STEMI. This case emphasizes the importance of a focused history in the initial evaluation of chest pain. Copyright © 2012 Elsevier Inc. All rights reserved.

DEVELOPING THE 21ST-CENTURY SOCIAL STUDIES SKILLS THROUGH TECHNOLOGY INTEGRATION

Directory of Open Access Journals (Sweden)

Mohammad Imam FARISI

2016-01-01

Full Text Available Recently, technology has become an educational necessity in global-digital era. Facing these phenomena, social studies (SS should make innovations related to changes of 21st-century skills and learning paradigm, which is characterized by the principles of disclosure of information, computing, automation, and communication. Technology integration into SS learning is one of the learning innovations in the global-digital era, and powerfully supports the National Council for Social Studies (NCSS as stated in their visions: meaningful, powerful, value-based, challenging, and active. It also strongly supports the development of three core skills of the 21st-century, including learning and innovation skills; information, media and technology skills; life and career skills that developed in partnership with the Partnership Forum for 21st-Century Skills (P21. This paper examines and describes academics evolution toward a commitment and further developments in research; 21stcentury skills map for the SS; and the implications for developing teachers’ competences and teachers’ education curriculum.

Economic and Financial Education for the 21st Century

Science.gov (United States)

Schug, Mark; Lopus, Jane

2008-01-01

The Partnership for 21st Century Skills places an important emphasis on fundamental social science subjects including history, geography, government and civics, and economics as well as a stress on other important subjects such as English, foreign languages, arts, and science in the school curriculum. It has also identified what it calls 21st…

Pretreatment with soluble ST2 reduces warm hepatic ischemia/reperfusion injury

International Nuclear Information System (INIS)

Yin Hui; Huang Baojun; Yang Heng; Huang Yafei; Xiong Ping; Zheng Fang; Chen Xiaoping; Chen Yifa; Gong Feili

2006-01-01

The interleukin-1 receptor-like protein ST2 exists in both membrane-bound (ST2L) and soluble form (sST2). ST2L has been found to play an important regulatory role in Th2-type immune response, but the function of soluble form of ST2 remains to be elucidated. In this study, we report the protective effect of soluble ST2 on warm hepatic ischemia/reperfusion injury. We constructed a eukaryotic expression plasmid, psST2-Fc, which expresses functional murine soluble ST2-human IgG1 Fc (sST2-Fc) fusion protein. The liver damage after ischemia/reperfusion was significantly attenuated by the expression of this plasmid in vivo. sST2-Fc remarkably inhibited the activation of Kupffer cells and the production of proinflammatory mediators TNF-α and IL-6. Furthermore, the levels of TLR4 mRNA and the nuclear translocation of NF-κB were also suppressed by pretreatment with sST2-Fc. These results thus identified soluble ST2 as a negative regulator in hepatic I/R injury, possibly via ST2-TLR4 pathway

Dignified Teacher Working Conditions in the 21st Century, an Inalienable Right, not an Option

Directory of Open Access Journals (Sweden)

Guiselle María Garbanzo-Vargas

2011-11-01

Full Text Available The author develops the topic of appropriate teacher working conditions in the challenging 21st Century. The objective is the contextualization of the emergent society in the 21st Century; propose a review of the Latin American educational context and the working conditions of education professionals. Another objective is to review the working conditions of teachers in different educations systems, including Europe and Latin America, among others. The profile of the 21st Century educator is defined in this paper, in comparison to teachers in the traditional society. In addition, this paper includes some indicators of consensus in different educational realities, and their integration in the cognitive, operational and institutional areas. The main conclusions include the necessity of policy-making to support dignified teacher working conditions, which is basic for an inclusive education of quality, in accordance with the demands of a challenging emerging society. The author concludes that this issue does not come to an end; it must always be in the educational agenda of society.

ST segment/heart rate slope as a predictor of coronary artery disease: comparison with quantitative thallium imaging and conventional ST segment criteria

International Nuclear Information System (INIS)

Finkelhor, R.S.; Newhouse, K.E.; Vrobel, T.R.; Miron, S.D.; Bahler, R.C.

1986-01-01

The ST segment shift relative to exercise-induced increments in heart rate, the ST/heart rate slope (ST/HR slope), has been proposed as a more accurate ECG criterion for diagnosing significant coronary artery disease (CAD). Its clinical utility, with the use of a standard treadmill protocol, was compared with quantitative stress thallium (TI) and standard treadmill criteria in 64 unselected patients who underwent coronary angiography. The overall diagnostic accuracy of the ST/HR slope was an improvement over TI and conventional ST criteria (81%, 67%, and 69%). For patients failing to reach 85% of their age-predicted maximal heart rate, its diagnostic accuracy was comparable with TI (77% and 74%). Its sensitivity in patients without prior myocardial infarctions was equivalent to that of thallium (91% and 95%). The ST/HR slope was directly related to the angiographic severity (Gensini score) of CAD in patients without a prior infarction (r = 0.61, p less than 0.001). The ST/HR slope was an improved ECG criterion for diagnosing CAD and compared favorably with TI imaging

E-st@r-I experience: Valuable knowledge for improving the e-st@r-II design

Science.gov (United States)

Corpino, S.; Obiols-Rabasa, G.; Mozzillo, R.; Nichele, F.

2016-04-01

Many universities all over the world have now established hands-on education programs based on CubeSats. These small and cheap platforms are becoming more and more attractive also for other-than-educational missions, such as technology demonstration, science applications, and Earth observation. This new paradigm requires the development of adequate technology to increase CubeSat performance and mission reliability, because educationally-driven missions have often failed. In 2013 the ESA Education Office launched the Fly Your Satellite! Programme which aims at increasing CubeSat mission reliability through several actions: to improve design implementation, to define best practices for conducting the verification process, and to make the CubeSat community aware of the importance of verification. Within this framework, the CubeSat team at Politecnico di Torino developed the e-st@r-II CubeSat as follow-on of the e-st@r-I satellite, launched in 2012 on the VEGA Maiden Flight. E-st@r-I and e-st@r-II are both 1U satellites with educational and technology demonstration objectives: to give hands-on experience to university students and to test an active attitude determination and control system based on inertial and magnetic measurements with magnetic actuation. This paper describes the know-how gained thanks to the e-st@r-I mission, and how this heritage has been translated into the improvement of the new CubeSat in several areas and lifecycle phases. The CubeSat design has been reviewed to reduce the complexity of the assembly procedure and to deal with possible failures of the on-board computer, for example re-coding the software in the communications subsystem. New procedures have been designed and assessed for the verification campaign accordingly to ECSS rules and with the support of ESA specialists. Different operative modes have been implemented to handle some anomalies observed during the operations of the first satellite. A new version of the on-board software is

Globalization of S&T: Key Challenges Facing DOD

Science.gov (United States)

2012-02-01

the necessary manufacturing methods. It may include concepts for novel marketing strategies to achieve widespread successful implementation in...Scanning 14. Scenario Workshops 15. Science Fictioning 16. Simulation Gaming 17. Surveys 18. SWOT Analysis 19. Weak Signals...employs the results of a full economic analysis for the period 2005–2050 to estimate the S&T knowledge production for each of the world’s 17 largest

ST2 Deficiency Ameliorates High Fat Diet-Induced Liver Steatosis In BALB/c Mice

Directory of Open Access Journals (Sweden)

Jovicic Nemanja

2015-03-01

Full Text Available Non-alcoholic fatty liver disease (NAFLD is strongly associated with obesity, but the molecular mechanisms of liver steatosis and its progression to non-alcoholic steatohepatitis and fibrosis are incompletely understood. Immune reactivity plays an important role in the pathogenesis of NAFLD. The IL-33/ST2 axis has a protective role in adiposity and atherosclerosis, but its role in obesity-associated metabolic disorders requires further clarification. To investigate the unresolved role of IL-33/ST2 signalling in NAFLD, we used ST2-deficient (ST2-/- and wild type (WT BALB/c mice maintained on a high-fat diet (HFD for 24 weeks. HFD-fed ST2-/- mice exhibited increased weight gain, visceral adipose tissue weight and triglyceridaemia and decreased liver weight compared with diet-matched WT mice. Compared with WT mice on an HFD, ST2 deletion significantly reduced hepatic steatosis, liver inflammation and fibrosis and downregulated the expression of genes related to lipid metabolism in the liver. The frequency of innate immune cells in the liver, including CD68+ macrophages and CD11c+ dendritic cells, was lower in HFD-fed ST2-/- mice, accompanied by lower TNFα serum levels compared with diet-matched WT mice. Less collagen deposition in the livers of ST2-/- mice on an HFD was associated with lower numbers of profibrotic CD11b+Ly6clow monocytes and CD4+IL-17+ T cells in the liver, lower hepatic gene expression of procollagen, IL-33 and IL-13, and lower serum levels of IL-33 and IL-13 compared with diet-matched WT mice.

21st century skills needed by students in technical and vocational education and training (TVET

Directory of Open Access Journals (Sweden)

Edward M. Reeve

2017-10-01

Full Text Available Those involved in Technical and Vocational Education and Training (TVET must properly prepare their students to live and work in the 21st Century. This preparation includes providing students with a solid knowledge and skills in the discipline being studied and developing instruction based on contemporary educational thinking and practices. It also means providing them with important skills needed in 21st Century. The purpose of this paper is to introduce the reader to important and “key” 21st Century Skills that the author believes are needed by students enrolled in TVET programs and to provide suggestions on how to build these skills into TVET programs. In this paper, the following “key” 21st Century Skills were reviewed: Science, Technology, Engineering, Mathematics (STEM; Problem-Solving; and the Four 4Cs: Critical Thinking, Communication, Collaboration, & Creativity.

Electrocardiogram ST-Segment Morphology Delineation Method Using Orthogonal Transformations.

Directory of Open Access Journals (Sweden)

Miha Amon

Full Text Available Differentiation between ischaemic and non-ischaemic transient ST segment events of long term ambulatory electrocardiograms is a persisting weakness in present ischaemia detection systems. Traditional ST segment level measuring is not a sufficiently precise technique due to the single point of measurement and severe noise which is often present. We developed a robust noise resistant orthogonal-transformation based delineation method, which allows tracing the shape of transient ST segment morphology changes from the entire ST segment in terms of diagnostic and morphologic feature-vector time series, and also allows further analysis. For these purposes, we developed a new Legendre Polynomials based Transformation (LPT of ST segment. Its basis functions have similar shapes to typical transient changes of ST segment morphology categories during myocardial ischaemia (level, slope and scooping, thus providing direct insight into the types of time domain morphology changes through the LPT feature-vector space. We also generated new Karhunen and Lo ève Transformation (KLT ST segment basis functions using a robust covariance matrix constructed from the ST segment pattern vectors derived from the Long Term ST Database (LTST DB. As for the delineation of significant transient ischaemic and non-ischaemic ST segment episodes, we present a study on the representation of transient ST segment morphology categories, and an evaluation study on the classification power of the KLT- and LPT-based feature vectors to classify between ischaemic and non-ischaemic ST segment episodes of the LTST DB. Classification accuracy using the KLT and LPT feature vectors was 90% and 82%, respectively, when using the k-Nearest Neighbors (k = 3 classifier and 10-fold cross-validation. New sets of feature-vector time series for both transformations were derived for the records of the LTST DB which is freely available on the PhysioNet website and were contributed to the LTST DB. The

Home of the 151st Air Refueling Wing

Science.gov (United States)

History HRA Alley Public Affairs SAPR Units Contact Us Search 151st ARW: 151st ARW The Roland R. Wright woman in the profession of arms President Trump visits Roland R. Wright Air National Guard Base 151st Commentaries Women's History Month: looking around as important as looking back Veterans Day: Pay tribute with

Virulence of invasive Salmonella Typhimurium ST313 in animal models of infection.

Directory of Open Access Journals (Sweden)

Girish Ramachandran

2017-08-01

Full Text Available Salmonella Typhimurium sequence type (ST 313 produces septicemia in infants in sub-Saharan Africa. Although there are known genetic and phenotypic differences between ST313 strains and gastroenteritis-associated ST19 strains, conflicting data about the in vivo virulence of ST313 strains have been reported. To resolve these differences, we tested clinical Salmonella Typhimurium ST313 and ST19 strains in murine and rhesus macaque infection models. The 50% lethal dose (LD50 was determined for three Salmonella Typhimurium ST19 and ST313 strains in mice. For dissemination studies, bacterial burden in organs was determined at various time-points post-challenge. Indian rhesus macaques were infected with one ST19 and one ST313 strain. Animals were monitored for clinical signs and bacterial burden and pathology were determined. The LD50 values for ST19 and ST313 infected mice were not significantly different. However, ST313-infected BALB/c mice had significantly higher bacterial numbers in blood at 24 h than ST19-infected mice. ST19-infected rhesus macaques exhibited moderate-to-severe diarrhea while ST313-infected monkeys showed no-to-mild diarrhea. ST19-infected monkeys had higher bacterial burden and increased inflammation in tissues. Our data suggest that Salmonella Typhimurium ST313 invasiveness may be investigated using mice. The non-human primate results are consistent with clinical data, suggesting that ST313 strains do not cause diarrhea.

Virulence of invasive Salmonella Typhimurium ST313 in animal models of infection.

Science.gov (United States)

Ramachandran, Girish; Panda, Aruna; Higginson, Ellen E; Ateh, Eugene; Lipsky, Michael M; Sen, Sunil; Matson, Courtney A; Permala-Booth, Jasnehta; DeTolla, Louis J; Tennant, Sharon M

2017-08-01

Salmonella Typhimurium sequence type (ST) 313 produces septicemia in infants in sub-Saharan Africa. Although there are known genetic and phenotypic differences between ST313 strains and gastroenteritis-associated ST19 strains, conflicting data about the in vivo virulence of ST313 strains have been reported. To resolve these differences, we tested clinical Salmonella Typhimurium ST313 and ST19 strains in murine and rhesus macaque infection models. The 50% lethal dose (LD50) was determined for three Salmonella Typhimurium ST19 and ST313 strains in mice. For dissemination studies, bacterial burden in organs was determined at various time-points post-challenge. Indian rhesus macaques were infected with one ST19 and one ST313 strain. Animals were monitored for clinical signs and bacterial burden and pathology were determined. The LD50 values for ST19 and ST313 infected mice were not significantly different. However, ST313-infected BALB/c mice had significantly higher bacterial numbers in blood at 24 h than ST19-infected mice. ST19-infected rhesus macaques exhibited moderate-to-severe diarrhea while ST313-infected monkeys showed no-to-mild diarrhea. ST19-infected monkeys had higher bacterial burden and increased inflammation in tissues. Our data suggest that Salmonella Typhimurium ST313 invasiveness may be investigated using mice. The non-human primate results are consistent with clinical data, suggesting that ST313 strains do not cause diarrhea.

Genome sequencing and molecular characterisation of Staphylococcus aureus ST772-MRSA-V, "Bengal Bay Clone".

Science.gov (United States)

Monecke, Stefan; Baier, Vico; Coombs, Geoffrey W; Slickers, Peter; Ziegler, Albrecht; Ehricht, Ralf

2013-12-20

The PVL-positive ST772-MRSA-V is an emerging community-associated (CA-) MRSA clone that has been named Bengal Bay Clone since most patients have epidemiological connections to the Indian subcontinent. It is found increasingly common in other areas of the world. One isolate of ST772-MRSA-V was sequenced using the Illumina Genome Analyzer System. After initial assembling the multiple sequence contigs were analysed using different in-house annotation scripts. Results were compared to microarray hybridisation results of clinical isolates of ST772-MRSA-V, of related strains and to another ST772-MRSA-V genome sequence. According to MLST e-burst analysis, ST772-MRSA-V belongs to Clonal Complex (CC)1, differing from ST1 only in one MLST allele (pta-22). However, there are several additional differences including agr alleles (group II rather than III), capsule type (5 rather than 8), the presence of the egc enterotoxin gene cluster and of the enterotoxin homologue ORF CM14 as well as the absence of the enterotoxin H gene seh. Enterotoxin genes sec and sel are present. ST772-MRSA-V harbours the genes encoding enterotoxin A (sea) and PVL (lukS/F-PV). Both are located on the same prophage. ST772-MRSA-V may have emerged from the same lineage as globally spread CC1 and CC5 strains. It has acquired a variety of virulence factors, and for a CA-MRSA strain it has an unusually high number of genes associated with antibiotic resistance.

Henkilöstötilinpäätös konsultointiyritykselle

OpenAIRE

Halmesvaara, Riikka

2010-01-01

Tämän toiminnallisen opinnäytetyön tarkoituksena oli antaa Konsultointiyritykselle kokonaiskuvaa henkilöstöstä tekemällä ilmapiirikartoitustutkimus sekä kirjallinen henkilöstötilinpäätös, joka koostui henkilöstötuloslaskelmasta ja henkilöstökertomuksesta. Työ suoritettiin tutkimuksellisena kehittämishankkeena konsultointiyritykselle. Tutkimusongelmana oli kuvata Konsultointiyrityksen osaamispääomaa ja henkilöstön rakennetta sekä luoda työkalu strategiassa määriteltyjen henkilöstöä koskevien o...

St. John's Wort (Hypericum Perforatum) and Pregnancy

Science.gov (United States)

... best live chat Live Help Fact Sheets Share St. John’s Wort (Hypericum perforatum) Tuesday, 01 May 2018 ... risk. This sheet talks about whether exposure to St. John’s Wort may increase the risk for birth ...

DOE pollution prevention in the 21st century

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-10-01

This document presents abstracts of the topics covered in the DOE Pollution Prevention in the 21st Century conference held July 9-11, 1996. These topics include: model facilities; Federal/NEPA/stake- holders; microchemistry; solvents and reduction; education and outreach; return on investments; energy management; decontamination and decommissioning; planning and regulations; environmental restoration; recycling; affirmative procurement in the executive branch; construction and demolition; materials exchange; and ISO 2000.

DOE pollution prevention in the 21st century

International Nuclear Information System (INIS)

1996-01-01

This document presents abstracts of the topics covered in the DOE Pollution Prevention in the 21st Century conference held July 9-11, 1996. These topics include: model facilities; Federal/NEPA/stake- holders; microchemistry; solvents and reduction; education and outreach; return on investments; energy management; decontamination and decommissioning; planning and regulations; environmental restoration; recycling; affirmative procurement in the executive branch; construction and demolition; materials exchange; and ISO 2000

NARX neural network Prediction of SYMH and ASYH indices for geomagnetic storms of solar cycle 24 including recent St. Patrick's day, 2015 storm

Science.gov (United States)

Bhaskar, A. T.; Vichare, G.

2017-12-01

Here, an attempt is made to develop a prediction model for SYMH and ASYH geomagnetic indices using Artificial Neural Network (ANN). SYMH and ASYH indices represent longitudinal symmetric and asymmetric component of the ring current. The ring current state depends on its past conditions therefore, it is necessary to consider its history for prediction. To account this effect Nonlinear Autoregressive Network with eXogenous inputs (NARX) is implemented. This network considers input history of 30 minutes and output feedback of 120 minutes. Solar wind parameters mainly velocity, density and interplanetary magnetic field are used as inputs. SYMH and ASYH indices during geomagnetic storms of 1998-2013, having minimum SYMH training two independent networks. We present the prediction of SYMH and ASYH indices during 9 geomagnetic storms of solar cycle 24 including the recent largest storm occurred on St. Patrick's day, 2015. The present prediction model reproduces the entire time profile of SYMH and ASYH indices along with small variations of 10-30 minutes to good extent within noise level, indicating significant contribution of interplanetary sources and past state of the magnetosphere. However, during the main phase of major storms, residuals (observed-modeled) are found to be large, suggesting influence of internal factors such as magnetospheric processes.

ST2 IN REJECTION OF THE TRANSPLANTED HEART

Directory of Open Access Journals (Sweden)

O. P. Shevchenko

2015-01-01

Full Text Available This review summarizes the current literature devoted to the analysis of prognostic role of ST2 biomarker in rejection of the transplanted heart. ST2 is one of the most promising diagnostic markers of the development and severity of heart failure as well as the mortality risk in patients with cardiovascular diseases. ST2 is expressed in cardiomyocytes in response to a variety of pathological processes and mechanical damage to the heart, which allows diagnosing cardiovascular diseases before clinical manifestations. Presumably, measuring the level of ST2 in heart transplant may have diagnostic and prognostic value in the assessment of graft and risk of rejection. Currently, accumulated clinical data on the role of given biomarker in heart transplantation are not enough, and further research on the relation of ST2 levels with different clinical and laboratory parameters in heart recipients is necessary. 

Dimensionering af stålrammebygninger mod kipning

DEFF Research Database (Denmark)

Borchersen, E.; Frederiksen, J.O.; Skov, K.

Rapporten beskriver en metode til dimensionering af stålrammebygninger mod kipning. Metoden er baseret dels på elasticitetsteoretiske overvejelser, dels på forsøg udført med 3-charniers stålrammmer i fuld skala....

GeoTIFF of 3x3 m Bathymetry for St. Thomas & St. John, 2011, UTM 20N NAD83

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 3x3 meter resolution bathymetric surface for an area of shallow seabed surrounding St. Thomas and St....

Evolution of the framework for 21st century competencies

Directory of Open Access Journals (Sweden)

Sdenka Z. Salas-Pilco

2013-03-01

Full Text Available This article presents the successive changes and evolution of the frameworks for 21st century competencies, since the appearance of the first conceptual models during the final years of the last century, and also it is a review of the competencies that are needed in the 21st century with a special focus on the Information and Communication Technologies (ICT competencies. The included frameworks have been elaborated by diverse institutions such as international organizations, private consortia and also governments as a guideline for educational policies in elementary and secondary schools. Later, the frameworks are compared and analyzed according to a classification of the competencies into general categories, in order to visualize some trends and obtain some insights about the direction they are heading. Finally, it provides some suggestions for the conception of future frameworks.

Plutonium-induced osteosarcomas in the St. Bernard

International Nuclear Information System (INIS)

Taylor, G.N.; Thurman, G.B.; Mays, C.W.; Shabestari, L.; Angus, W.; Eaton, J.; Hitchman, J.

1978-01-01

Thirteen osteosarcomas have been observed among the 7 St. Bernards that have died following the injection of 239 Pu. Preliminary data indicate that the St. Bernard is about 6 times more sensitive than the Beagle, and about 150 times more sensitive than the average person is to 239 Pu-induced bone sarcomas. Thus, the St. Bernard may be an excellent model to study the pathogenesis of bone cancer induction, to evaluate the relationship between spontaneous susceptibility and radiosensitivity, and to determine whether or not radiosensitivity significantly affects the toxicity ratio

Characterization of seasonal reproduction in Virginia Tech Selection Line, St. Croix, and Suffolk ewes

OpenAIRE

Jordan, Katherine Mead

2008-01-01

This dissertation research contained three studies. The first two studies were conducted to investigate the ability of ewes to rebreed while lactating during seasonal anestrus. Breeds studied included the Virginia Tech Out-of-season (OOS) Line, which is a wool line genetically selected to lamb in the fall, and the St. Croix, a hair breed of tropical origin thought to be lowly seasonal. When January-lambing ewes were exposed to rams while lactating in April, significantly more OOS than St. ...

Genomic Analysis of Multidrug-Resistant Escherichia coli from North Carolina Community Hospitals: Ongoing Circulation of CTX-M-Producing ST131-H30Rx and ST131-H30R1 Strains.

Science.gov (United States)

Kanamori, Hajime; Parobek, Christian M; Juliano, Jonathan J; Johnson, James R; Johnston, Brian D; Johnson, Timothy J; Weber, David J; Rutala, William A; Anderson, Deverick J

2017-08-01

Escherichia coli sequence type 131 (ST131) predominates globally among multidrug-resistant (MDR) E. coli strains. We used whole-genome sequencing (WGS) to investigate 63 MDR E. coli isolates from 7 North Carolina community hospitals (2010 to 2015). Of these, 39 (62%) represented ST131, including 37 (95%) from the ST131- H 30R subclone: 10 (27%) from its H 30R1 subset and 27 (69%) from its H 30Rx subset. ST131 core genomes differed by a median of 15 (range, 0 to 490) single-nucleotide variants (SNVs) overall versus only 7 within H 30R1 (range, 3 to 12 SNVs) and 11 within H 30Rx (range, 0 to 21). The four isolates with identical core genomes were all H 30Rx. Epidemiological and clinical characteristics did not vary significantly by strain type, but many patients with MDR E. coli or H 30Rx infection were critically ill and had poor outcomes. H 30Rx isolates characteristically exhibited fluoroquinolone resistance and CTX-M-15 production, had a high prevalence of trimethoprim-sulfamethoxazole resistance (89%), sul1 (89%), and dfrA17 (85%), and were enriched for specific virulence traits, and all qualified as extraintestinal pathogenic E. coli The high overall prevalence of CTX-M-15 appeared to be possibly attributable to its association with the ST131- H 30Rx subclone and IncF[F2:A1:B-] plasmids. Some phylogenetically clustered non-ST131 MDR E. coli isolates also had distinctive serotypes/ fimH types, fluoroquinolone mutations, CTX-M variants, and IncF types. Thus, WGS analysis of our community hospital source MDR E. coli isolates suggested ongoing circulation and differentiation of E. coli ST131 subclones, with clonal segregation of CTX-M variants, other resistance genes, Inc-type plasmids, and virulence genes. Copyright © 2017 American Society for Microbiology.

Mercury bioaccumulation assessment for the St. Louis River Area of Concern (poster)

Science.gov (United States)

Elevated mercury concentrations have been documented in fish and invertebrates within the St. Louis River Area of Concern (AOC). Mercury bioavailability is affected by multiple factors, including mercury sources, sediment and water geochemistry, food web structure, individual fis...

Comparative Genomic Analysis of Globally Dominant ST131 Clone with Other Epidemiologically Successful Extraintestinal Pathogenic Escherichia coli (ExPEC Lineages

Directory of Open Access Journals (Sweden)

Sabiha Shaik

2017-10-01

Full Text Available Escherichia coli sequence type 131 (ST131, a pandemic clone responsible for the high incidence of extraintestinal pathogenic E. coli (ExPEC infections, has been known widely for its contribution to the worldwide dissemination of multidrug resistance. Although other ExPEC-associated and extended-spectrum-β-lactamase (ESBL-producing E. coli clones, such as ST38, ST405, and ST648 have been studied widely, no comparative genomic data with respect to other genotypes exist for ST131. In this study, comparative genomic analysis was performed for 99 ST131 E. coli strains with 40 genomes from three other STs, including ST38 (n = 12, ST405 (n = 10, and ST648 (n = 18, and functional studies were performed on five in-house strains corresponding to the four STs. Phylogenomic analysis results from this study corroborated with the sequence type-specific clonality. Results from the genome-wide resistance profiling confirmed that all strains were inherently multidrug resistant. ST131 genomes showed unique virulence profiles, and analysis of mobile genetic elements and their associated methyltransferases (MTases has revealed that several of them were missing from the majority of the non-ST131 strains. Despite the fact that non-ST131 strains lacked few essential genes belonging to the serum resistome, the in-house strains representing all four STs demonstrated similar resistance levels to serum antibactericidal activity. Core genome analysis data revealed that non-ST131 strains usually lacked several ST131-defined genomic coordinates, and a significant number of genes were missing from the core of the ST131 genomes. Data from this study reinforce adaptive diversification of E. coli strains belonging to the ST131 lineage and provide new insights into the molecular mechanisms underlying clonal diversification of the ST131 lineage.

Idaho National Laboratory Quarterly Performance Analysis - 1st Quarter FY2015

Energy Technology Data Exchange (ETDEWEB)

Mitchell, Lisbeth A. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-03-01

This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 73 reportable events (27 from the 1St Qtr FY-15 and 46 from the prior three reporting quarters), as well as 38 other issue reports (including nine not reportable events and Significant Category A and B conditions reported during the1st Qtr FY-15) identified at INL during the past 12 months.

New technologies for fire suppression on board naval craft, FiST

NARCIS (Netherlands)

Rahm, M.; Hiltz, J.; Wal, R. van der; Hertzberg, T.; Lindström, J.

2014-01-01

For three years Canada, Sweden and the Netherlands have been investigating new technologies for fire suppression on board naval crafts within the FiST project. The project has focused on a number of technologies. These included the evaluation of water based fire suppression systems and in particular

Cardiogenic shock with ST-segment elevation acute coronary syndrome (ReNa-Shock ST

Directory of Open Access Journals (Sweden)

Yanina Castillo Costa

2017-08-01

Full Text Available Cardiogenic shock (CS in the setting of an ST-segment elevation myocardial infarction (STEMI is a severe complication and constitutes one of the principal causes of death associated with this condition. The aim of this study was to describe the clinical characteristics, treatment strategies and hospital outcome of CS associated with STEMI in Argentina. The Argentine Registry of Cardiogenic Shock (ReNA-Shock was a prospective and multicenter registry of consecutive patients with CS hospitalized in 64 centers in Argentina between July 2013 and May 2015. Only those with ST-segment elevation myocardial infarction (STEMI were selected for this analysis. Of the 165 patients included in the ReNa-Shock registry, 124 presented STEMI. Median age was 64 years (IQR 25-75: 56.5-75 and 67% were men; median time from symptom onset to admission was 240 minutes (IQR 25-75: 132-720. 63% of the cases presented CS at admission. Eighty-seven percent underwent reperfusion therapy: 80% primary percutaneous intervention with a median door-to-balloon time of 110 minutes (IQR 25-75: 62-184. Inotropic agents were used in 96%; 79% required mechanical ventilation; a Swan Ganz catheter was inserted in 47% and 35% required intra-aortic balloon pumping. Most patients (59% presented multivessel disease (MV. Hospital mortality was 54%. Multivariate analysis identified that time from symptom onset to admission (> 240 min was the only independent predictor of mortality (OR: 3.04; CI 95%: 1.18-7.9. Despite using treatment strategies currently available, morbidity and mortality of STEMI complicated with CS remains high.

The 21st Century Skills and Job Performance of Teachers

Science.gov (United States)

Pa-alisbo, Mark Anthony Cenas

2017-01-01

The Philippines' Department of Education through the implementation of the Basic Education Sector Reform Agenda (BESRA) is pursuing a package of policy reforms to further improve education. One of its reforms is the K-12 Program which has opened the way to the mandated 21st Century Skills. These include Learning and Innovation; Information, Media…

St. Louis FUSRAP Lessons Learned

International Nuclear Information System (INIS)

Eberlin, J.; Williams, D.; Mueller, D.

2003-01-01

The purpose of this paper is to present lessons learned from fours years' experience conducting Remedial Investigation and Remedial Action activities at the St. Louis Downtown Site (SLDS) under the Formerly Utilized Sites Remedial Action Program (FUSRAP). Many FUSRAP sites are experiencing challenges conducting Remedial Actions within forecasted volume and budget estimates. The St. Louis FUSRAP lessons learned provide insight to options for cost effective remediation at FUSRAP sites. The lessons learned are focused on project planning (budget and schedule), investigation, design, and construction

Biomechanics of the cornea evaluated by spectral analysis of waveforms from ocular response analyzer and Corvis-ST.

Directory of Open Access Journals (Sweden)

Sushma Tejwani

Full Text Available In this study, spectral analysis of the deformation signal from Corvis-ST (CoST and reflected light intensity from ocular response analyzer (ORA was performed to evaluate biomechanical concordance with each other.The study was non-interventional, observational, cross-sectional and involved 188 eyes from 94 normal subjects. Three measurements were made on each eye with ORA and CoST each and then averaged for each device. The deformation signal from CoST and reflected light intensity (applanation signal from ORA was compiled for all the eyes. The ORA signal was inverted about a line joining the two applanation peaks. All the signals were analyzed with Fourier series. The area under the signal curves (AUC, root mean square (RMS of all the harmonics, lower order (LO included 1st and 2nd order harmonic, higher order (HO up to 6th harmonic, CoST deformation amplitude (DA, corneal hysteresis (CH and corneal resistance factor (CRF were analyzed.The device variables and those calculated by Fourier transform were statistically significantly different between CoST and ORA. These variables also differed between the eyes of the same subject. There was also statistically significant influence of eyes (left vs. right on the differences in a sub-set of RMS variables only. CH and CRF differed statistically significantly between the eyes of subject (p<0.001 but not DA (p = 0.65.CoST was statistically significantly different from ORA. CoST may be useful in delineating true biomechanical differences between the eyes of a subject as it reports deformation.

21st Century Skills Map: The Arts

Science.gov (United States)

Dean, Colleen; Ebert, Christie M. Lynch; McGreevy-Nichols, Susan; Quinn, Betsy; Sabol, F. Robert; Schmid, Dale; Shauck, R. Barry; Shuler, Scott C.

2010-01-01

This 21st Century Skills Map is the result of hundreds of hours of research, development and feedback from educators and business leaders across the nation. The Partnership for 21st Century Skills has issued this map for the core subject of the Arts.

Plutonium-induced osteosarcomas in the St. Bernard

International Nuclear Information System (INIS)

Taylor, G.N.; Thurman, G.B.; Mays, C.W.; Shabestari, L.; Angus, W.; Atherton, D.R.

1981-01-01

Fourteen osteosarcomas were observed among the eight St. Bernards that died following the injection of 239 Pu. Early data tentatively indicate that the St. Bernard is about 5 times more sensitive than the beagle and about 130 times more sensitive than the average person is estimated to be to 239 Pu-induced bone sarcomas. Thus the St. Bernard may be an excellent model in which to study the pathogenesis of bone cancer induction, to evaluate the relationship between spontaneous susceptibility and radiosensitivity, and to determine whether radiosensitivity significantly affects the toxicity ration of 239 Pu/ 226 Ra

St. Vicent Ferrer’s Catalán sermon on St. Martin of Tours

Directory of Open Access Journals (Sweden)

Ferreiro, Alberto

2013-12-01

Full Text Available One of the most widely venerated saints in the Middle Ages was St. Martin of Tours whose cult continues to this day in many parts of the world. In the Middle Ages, he became as popular as other major saints such as Thomas Becket, Santiago de Compostela and the Virgin Mary. St. Martin’s cult became very prominent in the Iberian Peninsula before and after the emergence of the cult of Santiago de Compostela. In St. Vicent Ferrer’s voluminous sermons this one in Catalán is dedicated to this most venerated Gallic saint. The most important late antique and early medieval sources that form the background of this sermon are by Sulpicius Severus- the Gallus and Vita Sancti Martini. In the high Middle Ages, however, his cult was popularized through the Legenda Aurea written by the Dominican Jacobus of Voragine, who synthesized Sulpicius’ two works on St. Martin. Moreover, St. Vicent preached not to make any major doctrinal breakthroughs- his main interest was to evangelize, not to write academic theology- he nevertheless exhibited great creativity. The object of this study is St. Vicent’s Catalán sermon Alius Sermo Sancti Martini, CXXXIV.Uno de los santos más venerados en la edad media fue San Martín de Tours, cuyo culto continúa hasta hoy en muchas partes del mundo. En la edad media, se hizo tan popular como otros grandes Santos: Thomas Becket, Santiago de Compostela y la Virgen María. El culto de San Martín se hizo prominente en la Península Ibérica antes y después de la aparición del culto a Santiago de Compostela. En los sermones voluminosos de San Vicente Ferrer esta uno en Catalán que está dedicado a este santo tan venerado de Galia. Las fuentes más importantes procedentes de la antigu.edad tardía y principios medievales que forma el fondo de este sermón son Gallus y la Vita Sancti Martini de Sulpicio Severo. Sin embargo, en la alta edad media, su culto se popularizó a través de la Legenda Aurea escrita por el dominico

Frauen mit Eßstörungen im Ausdauersport

OpenAIRE

Bös, Annette

2003-01-01

Die vorliegende Arbeit untersucht das Phänomen Eßstörungen bei Ausdauersportlerinnen. Auf dem Hintergrund des identitätstheoretischen Ansatzes von Stahr et al. (1995) geht es um die Frage nach den Hauptverursachungsmomenten der Eßstörungen von sieben jungen Sportlerinnen. Im Rahmen einer qualitativen Sozialforschungsarbeit wurden sieben Athletinnen in einem problemzentrierten Interview zur Phase ihrer Eßstörungserkrankung befragt. Die Arbeit setzt sich zum Ziel, einen Beitrag zur systematisch...

IAEA safeguards for the 21st century

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-07-01

The publication includes the lectures held during the seminar on IAEA safeguards for the 21st century. The topics covered are as follows: the nuclear non-proliferation regime; Legal instruments related to the application of safeguards; multilateral nuclear export controls; physical protection and its role in nuclear non-proliferation; the evolution of safeguards; basis for the strengthening of safeguards; information required from states, including 'small quantities protocol'; processing and evaluation of new information for strengthened safeguards; additional physical access and new technologies for strengthened safeguards; equipping the IAEA Inspectorate with new skills; achievements to date the strengthened safeguards; complement ofregional non-proliferation arrangements in international nuclear verification; promotion of transparency through Korean experience; and the future prospects of safeguards.

Safety and licensing analyses for the Fort St. Vrain HTGR

International Nuclear Information System (INIS)

Ball, S.J.; Conklin, J.C.; Harrington, R.M.; Cleveland, J.C.; Clapp, N.E. Jr.

1982-01-01

The Oak Ridge National Laboratory (ORNL) safety analysis program for the HTGR includes development and verification of system response simulation codes, and applications of these codes to specific Fort St. Vrain reactor licensing problems. Licensing studies addressed the oscillation problems and the concerns about large thermal stresses in the core support blocks during a postulated accident

Kirjallisuuskatsaus tiimityöstä

OpenAIRE

Uimi, Jutta

2012-01-01

Laurea-ammattikorkeakoulu Tiivistelmä Laurea Lohja Hoitotyön koulutusohjelma Uimi Jutta Kirjallisuuskatsaus tiimityöstä Vuosi 2012 Sivumäärä 43 Tämän opinnäytetyön tavoitteena oli kuvata kirjallisuuskatsauksen muodossa, miten tiimityö määritellään terveydenhuollon organisaatiossa ja tiimityön käytettävyyttä sekä millaisissa yhteyksissä tiimityötä käytetään. Tarkoituksena oli tuottaa tutkittua tietoa tiimityöstä Helsingin ja Uudenmaan sairaanhoitopiiriin (HUS) kuulu...

Intraurban Spatiotemporal Variability of Ambient Air Pollutants across Metropolitan St. Louis

Science.gov (United States)

Du, Li

Ambient air monitoring networks have been established in the United States since the 1970s to comply with the Clean Air Act. The monitoring networks are primarily used to determine compliance but also provide substantive support to air quality management and air quality research including studies on health effects of air pollutants. The Roxana Air Quality Study (RAQS) was conducted at the fenceline of a petroleum refinery in Roxana, Illinois. In addition to providing insights into air pollutant impacts from the refinery, these measurements increased the St. Louis area monitoring network density for gaseous air toxics and fine particulate matter (PM2.5) speciation and thus provided an opportunity to examine intraurban spatiotemporal variability for these air quality parameters. This dissertation focused on exploring and assessing aspects of ambient air pollutant spatiotemporal variability in the St. Louis area from three progressively expanded spatial scales using a suite of methods and metrics. RAQS data were used to characterize air quality conditions in the immediate vicinity of the petroleum refinery. For example, PM2.5 lanthanoids were used to track impacts from refinery fluidized bed catalytic cracker emissions. RAQS air toxics data were interpreted by comparing to network data from the Blair Street station in the City of St. Louis which is a National Air Toxics Trends Station. Species were classified as being spatially homogeneous (similar between sites) or heterogeneous (different between sites) and in the latter case these differences were interpreted using surface winds data. For PM 2.5 species, there were five concurrently operating sites in the St. Louis area - including the site in Roxana - which are either formally part of the national Chemical Speciation Network (CSN) or rigorously follow the CSN sampling and analytical protocols. This unusually large number of speciation sites for a region the size of St. Louis motivated a detailed examination of

Marine and inland fishes of St. Croix, U. S. Virgin Islands: an annotated checklist.

Science.gov (United States)

Smith-Vaniz, William F; Jelks, Howard L

2014-05-29

An historical account is given for the ichthyological research at St. Croix, U. S. Virgin Islands, followed by an annotated list of 544 species of mostly marine shore fishes known or reported from the island to depths of 200 m. Color photographs are included for 103 of these species. Collections made at Buck Island Reef National Monument with the ichthyocide rotenone in 2001 and 2005 increased the known ichthyofauna by about 80 species. The rational for inclusion of each species in the checklist is given, with remarks for those species for which additional documentation or voucher specimens are needed. Reports of species known or presumed to have been based on misidentifications are discussed. Of the total marine fish fauna of the island, 404 species (75%) are restricted to the western Atlantic Ocean, (223 of these species are essentially Caribbean endemics that do not occur south of the Amazon River outflow), and no St. Croix endemic species are known. An additional 17 species (3.2%) also occur at mid-Atlantic islands, 57 species (10.6 %) are limited to both sides of the Atlantic Ocean, and 40 species (7.4%) have circumtropical distributions. The four most species-rich families are the Gobiidae (47 species), Serranidae (groupers and sea basses, 41), Labridae (wrasses and parrotfishes, 31), and Labrisomidae (scaly blennies, 27). Literature reports of Mosquitofish, Gambusia sp., from St. Croix apparently were based on misidentifications of a different introduced poeciliid genus. Four species of the amphidromus goby genus Sicydium occur in St. Croix inland waters, together with three established introduced species (one cichlid and two poeciliids). Also included are one catfish (Ictaluridae) and three sunfishes (Centrarchidae) known only from ponds. The Lionfish, Pterois volitans, the only introduced marine species, was first reported from St. Croix in 2008 and is now common despite control efforts.

Marine and inland fishes of St. Croix, U. S. Virgin Islands: an annotated checklist

Science.gov (United States)

Smith-Vaniz, William F.; Jelks, Howard L.

2014-01-01

An historical account is given for the ichthyological research at St. Croix, U. S. Virgin Islands, followed by an annotated list of 544 species of mostly marine shore fishes known or reported from the island to depths of 200 m. Color photographs are included for 103 of these species. Collections made at Buck Island Reef National Monument with the ichthyocide rotenone in 2001 and 2005 increased the known ichthyofauna by about 80 species. The rational for inclusion of each species in the checklist is given, with remarks for those species for which additional documentation or voucher specimens are needed. Reports of species known or presumed to have been based on misidentifications are discussed. Of the total marine fish fauna of the island, 404 species (75%) are restricted to the western Atlantic Ocean, (223 of these species are essentially Caribbean endemics that do not occur south of the Amazon River outflow), and no St. Croix endemic species are known. An additional 17 species (3.2%) also occur at mid-Atlantic islands, 57 species (10.6 %) are limited to both sides of the Atlantic Ocean, and 40 species (7.4%) have circumtropical distributions. The four most species-rich families are the Gobiidae (47 species), Serranidae (groupers and sea basses, 41), Labridae (wrasses and parrotfishes, 31), and Labrisomidae (scaly blennies, 27). Literature reports of Mosquitofish, Gambusia sp., from St. Croix apparently were based on misidentifications of a different introduced poeciliid genus. Four species of the amphidromus goby genus Sicydium occur in St. Croix inland waters, together with three established introduced species (one cichlid and two poeciliids). Also included are one catfish (Ictaluridae) and three sunfishes (Centrarchidae) known only from ponds. The Lionfish, Pterois volitans, the only introduced marine species, was first reported from St. Croix in 2008 and is now common despite control efforts.

ST-segment resolution with bivalirudin versus heparin and routine glycoprotein IIb/IIIa inhibitors started in the ambulance in ST-segment elevation myocardial infarction patients transported for primary percutaneous coronary intervention: The EUROMAX ST-segment resolution substudy.

Science.gov (United States)

Van't Hof, Arnoud; Giannini, Francesco; Ten Berg, Jurrien; Tolsma, Rudolf; Clemmensen, Peter; Bernstein, Debra; Coste, Pierre; Goldstein, Patrick; Zeymer, Uwe; Hamm, Christian; Deliargyris, Efthymios; Steg, Philippe G

2017-08-01

Myocardial reperfusion after primary percutaneous coronary intervention (PCI) can be assessed by the extent of post-procedural ST-segment resolution. The European Ambulance Acute Coronary Syndrome Angiography (EUROMAX) trial compared pre-hospital bivalirudin and pre-hospital heparin or enoxaparin with or without GPIIb/IIIa inhibitors (GPIs) in primary PCI. This nested substudy was performed in centres routinely using pre-hospital GPI in order to compare the impact of randomized treatments on ST-resolution after primary PCI. Residual cumulative ST-segment deviation on the single one hour post-procedure electrocardiogram (ECG) was assessed by an independent core laboratory and was the primary endpoint. It was calculated that 762 evaluable patients were needed to show non-inferiority (85% power, alpha 2.5%) between randomized treatments. A total of 871 participated with electrocardiographic data available in 824 patients (95%). Residual ST-segment deviation one hour after PCI was 3.8±4.9 mm versus 3.9±5.2 mm for bivalirudin and heparin+GPI, respectively ( p=0.0019 for non-inferiority). Overall, there were no differences between randomized treatments in any measures of ST-segment resolution either before or after the index procedure. Pre-hospital treatment with bivalirudin is non-inferior to pre-hospital heparin + GPI with regard to residual ST-segment deviation or ST-segment resolution, reflecting comparable myocardial reperfusion with the two strategies.

St. Sofia in Ohrid, space, structure, forms: Sources

Directory of Open Access Journals (Sweden)

Korać Vojislav

2008-01-01

Full Text Available This work comments in particular on studies dealing with the church of St. Sofia in Ohrid. Among them are the monographs of two authors, Barbara Maria Schellewald (Die Arhitektur der Sophien Kirchen in Ohrid, Bon 1986 and Boris Čipan (Sveta Sofija, katedralen hram na ohridskata arhiepiskopija, Skopje 1995. Special attention is devoted to the typological interpretation of St. Sofia, to its initial design as a triple-nave basilica with a dome at the centre. Insightful descriptions are given about the older monuments in the Byzantine capital, Constantinople. Special attention is paid to the external architectonic workmanship. The western façade of St. Sofia demonstrates the features of Late Byzantine architecture, while the eastern façade directly reveals the triple-nave spatial design. That is why this article on St. Sofia contains sketches of the western and the eastern façades, illustrating the features of its architectonic specificities. On the whole, the author presents St. Sofia in Ohrid as a unique work of architecture of the Byzantine region. .

The 21st Century as Whose Century?

Directory of Open Access Journals (Sweden)

David Scott

2015-08-01

Full Text Available Macro-analysis and East-West encounter are shown through consideration of objective yet subjective constructed concepts for the international system and international economy in the 21st century. Three paradigms are considered, namely the 21st century as the ‘Pacific Century’, as ‘China’s Century’ and as the ‘Asian Century’. Overlaps are shown between these three paradigms, as also developments in time, and gradually shift in geographical location. The ‘Pacific Century’, and its associated Rimspeak, was the paradigm emerging in the late 1970s, knitting together America’s West Coast and the Japanese economy. By the late 1980s this was already shifting to talk of the 21st century likely to be an ‘Asian Century’ model, mark-1, based on the Pacific Asia dynamism shown by the ‘Asian Tigers’ and Japan. However, the Asian financial crash of 1997-8, and the economic downturn in Japan, meant that such an ‘Asian Century’ seemed premature as the 21st century arrived. Instead, it was China’s economic growth that seemed most evident, and with it the concept of the 21st century as ‘China’s Century’. However, in turn that has already been modified during the first decade of the century by India’s arrival as a rapidly growing economy. Consequently the 21st century as ‘China’s Century’ and as ‘India’s Century’ has been combined into talk of an ‘Asian Century’, mark-2.

Evolutionary History of the Global Emergence of the Escherichia coli Epidemic Clone ST131.

Science.gov (United States)

Stoesser, Nicole; Sheppard, Anna E; Pankhurst, Louise; De Maio, Nicola; Moore, Catrin E; Sebra, Robert; Turner, Paul; Anson, Luke W; Kasarskis, Andrew; Batty, Elizabeth M; Kos, Veronica; Wilson, Daniel J; Phetsouvanh, Rattanaphone; Wyllie, David; Sokurenko, Evgeni; Manges, Amee R; Johnson, Timothy J; Price, Lance B; Peto, Timothy E A; Johnson, James R; Didelot, Xavier; Walker, A Sarah; Crook, Derrick W

2016-03-22

Escherichia colisequence type 131 (ST131) has emerged globally as the most predominant extraintestinal pathogenic lineage within this clinically important species, and its association with fluoroquinolone and extended-spectrum cephalosporin resistance impacts significantly on treatment. The evolutionary histories of this lineage, and of important antimicrobial resistance elements within it, remain unclearly defined. This study of the largest worldwide collection (n= 215) of sequenced ST131E. coliisolates to date demonstrates that the clonal expansion of two previously recognized antimicrobial-resistant clades, C1/H30R and C2/H30Rx, started around 25 years ago, consistent with the widespread introduction of fluoroquinolones and extended-spectrum cephalosporins in clinical medicine. These two clades appear to have emerged in the United States, with the expansion of the C2/H30Rx clade driven by the acquisition of ablaCTX-M-15-containing IncFII-like plasmid that has subsequently undergone extensive rearrangement. Several other evolutionary processes influencing the trajectory of this drug-resistant lineage are described, including sporadic acquisitions of CTX-M resistance plasmids and chromosomal integration ofblaCTX-Mwithin subclusters followed by vertical evolution. These processes are also occurring for another family of CTX-M gene variants more recently observed among ST131, theblaCTX-M-14/14-likegroup. The complexity of the evolutionary history of ST131 has important implications for antimicrobial resistance surveillance, epidemiological analysis, and control of emerging clinical lineages ofE. coli These data also highlight the global imperative to reduce specific antibiotic selection pressures and demonstrate the important and varied roles played by plasmids and other mobile genetic elements in the perpetuation of antimicrobial resistance within lineages. Escherichia coli, perennially a major bacterial pathogen, is becoming increasingly difficult to manage due to

St Sava and the cloud-chasers

OpenAIRE

Loma Aleksandar

2013-01-01

A gloss in the Nomocanon of St Sava condemns folk superstitions related to magically provoking hailstorms and eclipses. St Sava’s miracle with the king of Hungary as described in his Vitae seems to go back to the same complex of popular beliefs. Its acceptance by the hagiography was probably due to the influence of the figure of prince magician as common to the Serbian and the Russian oral epics.

St. Augustine in Twentieth-Century Music

DEFF Research Database (Denmark)

Petersen, Nils Holger

2012-01-01

A discussion - in a cultural historical perspective - of primarily two important twentieth-century musical works setting texts by St Augustine: Klaus Huber's Soliloquia Sancti Aurelii Augustini and Michael Tippett's The Vision of Saint Augustine.......A discussion - in a cultural historical perspective - of primarily two important twentieth-century musical works setting texts by St Augustine: Klaus Huber's Soliloquia Sancti Aurelii Augustini and Michael Tippett's The Vision of Saint Augustine....

Proximal ecological effects of the 1980 eruptions of Mount St. Helens

Science.gov (United States)

Swanson, F. J.

1988-01-01

The diversity of ecosystems and volcanic processes involved in the 1980 eruptions of Mount St. Helens, southwest Washington, provide an excellent setting for examining effects of volcanic events on ecosystems. These eruptions included a lateral blast, debris avalanche, mudflows, pyroclastic flows, and airfall tephra. Affected ecosystems within 30 km of the vent were lakes, streams, upland and riparian forest, and meadows. Ecological disturbances imposed by the Mount St. Helens events were predominantly physical, rather than climatic or chemical which are the dominant classes of disturbances considered in analysis of global catastrophes. Analysis of ecosystem response to disturbance should be based on consideration of composition and structure of the predisturbance system in terms that represent potential survivability of organisms, mechanisms in the primary disturbance, initial survivors, secondary disturbances arising from the primary disturbance and the biological responses to secondary disturbances, invasion of the site by new propagules, interactions among secondary disturbance processes and surviving and invading organisms. Predicting ecosystem response to disturbance is enchanced by considering the mechanisms of disturbance rather than type of disturbance. In the 1980 Mount St. Helens events, the disturbance types, involved primarily the mechanisms of sedimentation, heating, and shear stress. Each disturbance type involved one or more mechanisms. Ecosystem response varied greatly across the landscape. Analysis of ecosystem response to disturbance, regardless of type, should include detailed consideration of the properties of individual species, primary and secondary disturbance mechanisms, and their distributions across landscapes.

Risk Assessment in the 21st Century - Conference Abstract ...

Science.gov (United States)

For the past ~50 years, risk assessment depended almost exclusively on animal testing for hazard identification and dose-response assessment. Originally sound and effective, with increasing dependence on chemical tools and the number of chemicals in commerce, this traditional approach is no longer sufficient. This presentation provides an update on current progress in achieving the goals outlined in the NAS reports: “Toxicology Testing in the 21st Century”, “Exposure Science in the 21st Century”, and most recently, “Using 21st Century Science to Improve Risk-Related Evaluations.” The presentation highlights many of the advances lead by the EPA. Topics covered include the evolution of the mode of action concept into the chemically agnostic, adverse outcome pathway (AOP), a systems-based data framework that facilitates integration of modifiable factors (e.g., genetic variation, life stages), and an understanding of networks, and mixtures. Further, the EDSP pivot is used to illustrate how AOPs drive development of predictive models for risk assessment based on assembly of high throughput assays representing AOP key elements. The birth of computational exposure science, capable of large-scale predictive exposure models, is reviewed. Although still in its infancy, development of non-targeted analysis to begin addressing the exposome is presented, as is the systems-based AEP that integrates exposure, toxicokinetics and AOPs into a comprehensive framework

Outcome of Patients With Adenosine-Induced ST Segment Depression and Normal Myocardial Perfusion

International Nuclear Information System (INIS)

El-Refaei, S.; Selim, M.

2011-01-01

The aim of the present study was to determine the outcome of patients with normal MPS and adenosine-induced ST segment depression. A total of 1867 patients underwent adenosine Tc99m-tetrofosmin MPS in nuclear medicine unit in Saudi German Hospital, Saudi Arabia, between January 2004 and May 2008. Their ECGs were checked for ST segment depression during adenosine infusion. All patients with ≥ 1 mm horizontal or down-sloping ST segment depression or≥ 1.5 mm up-sloping ST segment depression were included in the study. Fifty-six patients met our inclusion criteria, of which 45 (80%) were females. During the follow-up period, a total of 15 of patients ended up doing coronary angiography, either for high clinical suspicion or following a second positive MPS performed 6-18 months after the first study. Seven of them were positive for coronary artery disease and were subsequently treated with revascularization procedure, and 8 returned either normal angiography or non-obstructive coronary artery disease. Male diabetic smoking patients were more prevalent and underwent revascularization. The patients were followed up for a mean of 22.8 ±7.8 months. No cardiac deaths or myocardial infarctions were reported. It could be concluded that adenosine-induced ST segment depression in patients with normal myocardial perfusion was a benign finding and did not increase the very low risk of cardiac events in those patients. However, male smokers and/or diabetics might need further investigation. This suggestion needs further evaluation

Henkilöstötilinpäätös Yritys Oy

OpenAIRE

Turunen, Tytti

2011-01-01

Tämän opinnäytetyön aiheena oli Yritys Oy:n henkilöstötilinpäätös vuodelta 2009. Henkilöstötilinpäätös jaetaan kahteen osaan, henkilöstötuloslaskelmaan ja henkilöstökertomukseen. Tavoitteena oli laatia Yritys Oy:lle henkilöstötilinpäätöksestä malli, jota yritys voi käyttää ja hyödyntää tulevaisuudessa henkilöstötilinpäätöstä laatiessa. Tavoitteena oli myös antaa kehittämisehdotuksia, minkälaista tietoa kannattaa kerätä seuraavia henkilöstötilinpäätöksiä varten. Henkilöstötilinpäätöksen tavoit...

The 21st Century Writing Program: Collaboration for the Common Good

Science.gov (United States)

Moberg, Eric

2010-01-01

The purpose of this report is to review the literature on theoretical frameworks, best practices, and conceptual models for the 21st century collegiate writing program. Methods include electronic database searches for recent and historical peer-reviewed scholarly literature on collegiate writing programs. The author analyzed over 65 sources from…

Status of the Fort St. Vrain decommissioning

International Nuclear Information System (INIS)

Fisher, M.J.

1990-01-01

Fort St. Vrain is a high temperature gas cooled reactor. It has been shut down as a result of financial and technical difficulties. Fort St. Vrain has been planning for defueling and decommissioning for at least three years. The preliminary decommissioning plan, in accordance with the NRC's final rule, has been submitted and is being reviewed by the NRC. The basis of the preliminary decommissioning plan has been SAFSTOR. Public Service Company, who is the owner and operator of FSV, is scheduled to submit a proposed decommissioning plan to the NRC in the fourth quarter of 1990. PSC has gone out for bid on the decontamination and dismantlement of FSV. This paper includes the defueling schedule, the independent spent fuel storage installation status, the probability of shipping fuel to DOE, the status of the preliminary decommissioning plan submittal, the issuance of a possession only license and what are the results of obtaining this license amendment, preliminary decommissioning activities allowed prior to the approval of a proposed decommissioning plan, the preparation of a proposed decommissioning plan and the status of our decision to proceed with SAFSTOR or DECON as identified in the NRC's final decommissioning rule

31st IMAC Conference on Structural Dynamics

CERN Document Server

Adams, Douglas; Carrella, Alex; Mayes, Randy; Rixen, Daniel; Allen, Matt; Cunha, Alvaro; Catbas, Fikret; Pakzad, Shamim; Racic, Vitomir; Pavic, Aleksandar; Reynolds, Paul; Simmermacher, Todd; Cogan, Scott; Moaveni, Babak; Papadimitriou, Costas; Allemang, Randall; Clerck, James; Niezrecki, Christopher; Wicks, Alfred

2013-01-01

Topics in Nonlinear Dynamics, Volume 1: Proceedings of the 31st IMAC, A Conference and Exposition on Structural Dynamics, 2013, the first volume of seven from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on fundamental and applied aspects of Structural Dynamics, including papers on:   Nonlinear Oscillations Nonlinearities In Practice Nonlinear System Identification: Methods Nonlinear System Identification: Friction & Contact Nonlinear Modal Analysis Nonlinear Modeling & Simulation Nonlinear Vibration Absorbers Constructive Utilization of Nonlinearity.

Chest-lead ST-J amplitudes using arm electrodes as reference instead of the Wilson central terminal in smartphone ECG applications: Influence on ST-elevation myocardial infarction criteria fulfillment.

Science.gov (United States)

Lindow, Thomas; Engblom, Henrik; Khoshnood, Ardavan; Ekelund, Ulf; Carlsson, Marcus; Pahlm, Olle

2018-05-07

"Smartphone 12-lead ECG" for the assessment of acute myocardial ischemia has recently been introduced. In the smartphone 12-lead ECG either the right or the left arm can be used as reference for the chest electrodes instead of the Wilson central terminal. These leads are labeled "CR leads" or "CL leads." We aimed to compare chest-lead ST-J amplitudes, using either CR or CL leads, to those present in the conventional 12-lead ECG, and to determine sensitivity and specificity for the diagnosis of STEMI for CR and CL leads. Five hundred patients (74 patients with ST elevation myocardial infarction (STEMI), 66 patients with nonischemic ST deviation and 360 controls) were included. Smartphone 12-lead ECG chest-lead ST-J amplitudes were calculated for both CR and CL leads. ST-J amplitudes were 9.1 ± 29 μV larger for CR leads and 7.7 ± 42 μV larger for CL leads than for conventional chest leads (V leads). Sensitivity and specificity were 94% and 95% for CR leads and 81% and 97% for CL leads when fulfillment of STEMI criteria in V leads was used as reference. In ischemic patients who met STEMI criteria in V leads, but not in limb leads, STEMI criteria were met with CR or CL leads in 91%. By the use of CR or CL leads, smartphone 12-lead ECG results in slightly lower sensitivity in STEMI detection. Therefore, the adjustment of STEMI criteria may be needed before application in clinical practice. © 2018 The Authors. Annals of Noninvasive Electrocardiology Published by Wiley Periodicals, Inc.

21st Century Skills Map: World Languages

Science.gov (United States)

Partnership for 21st Century Skills, 2011

2011-01-01

This 21st Century Skills Map is the result of hundreds of hours of research, development and feedback from educators and business leaders across the nation. The Partnership for 21st Century Skills has issued this map for the core subject of World Languages. [Funding for this paper was provided by EF Education.

Clinically Relevant ESBL-Producing K. pneumoniae ST307 and E. coli ST38 in an Urban West African Rat Population

Directory of Open Access Journals (Sweden)

Katharina Schaufler

2018-02-01

Full Text Available High-risk ESBL-producing Enterobacteriaceae (ESBL-E have been described in wild birds and rodents worldwide. Rats are of special interest not only due to their indicator role for environmental pollution with multi-resistant bacteria but also as possible infection source. Data on the presence of high-risk ESBL-E in urban wildlife from Africa remain scarce, however. Twenty-nine animals from three different rat (Rattus species were captured in the city of Conakry (Guinea, West Africa in 2015. Rectal swabs were analyzed for ESBL-E using selective media. Species typing and phenotypic antimicrobial resistance analysis to broad-spectrum beta-lactams and other classes of antimicrobials was performed for Enterobacteriaceae-like isolates using the VITEK®2 system (BioMérieux, Germany. Confirmed ESBL-producing E. coli and K. pneumoniae were whole-genome sequenced and resistance genes, phylogenetic background and genes related to bacterial fitness and virulence were analyzed. In total, six of twenty-nine rats (20% carried ESBL-E (K. pneumoniae and E. coli. All ESBL-producers were multi-drug resistant with blaCTX−M−15 as the dominating ESBL-type. Interestingly, ESBL-associated clonal lineages E. coli ST38 and K. pneumoniae ST307 were found. The ESBL-plasmid in K. pneumoniae ST307 revealed high sequence similarities to pKPN3-307_TypeC, a >200 kbp IncFII plasmid originating from a human clinical ST307 isolate. This was in contrast to the core genome: the rat isolate was distantly related to the human clinical ST307 isolate (27 SNPs/Mbp. In addition, we identified π-fimbrial, capsule 2, and glycogen synthesis clusters in the rodent ST307 isolate, whose involvement in the adaptation to survival outside the host and in human urinary tracts has been suggested. Our results demonstrate the presence of clinically relevant, ESBL-producing K. pneumoniae ST307 and E. coli ST38 clonal lineages in an urban West African rat population. The human community is likely

St Sava and the cloud-chasers

Directory of Open Access Journals (Sweden)

Loma Aleksandar

2013-01-01

Full Text Available A gloss in the Nomocanon of St Sava condemns folk superstitions related to magically provoking hailstorms and eclipses. St Sava’s miracle with the king of Hungary as described in his Vitae seems to go back to the same complex of popular beliefs. Its acceptance by the hagiography was probably due to the influence of the figure of prince magician as common to the Serbian and the Russian oral epics.

Manufacturing and Design Engineering Students St. Mary's Hospital, Phoenix Park.

OpenAIRE

Mitchell, Leah

2012-01-01

Poster with details of project to improve ease of movement for Kirton Stirling chairs in St. Mary's Hospital, Phoenix Park, Dublin. Third year students in the B Eng (Honours) Manufacturing and Design Engineering course at Bolton St. completed a project in conjunction with St. Mary‟s Hospital, Phoenix Park. The staff in St Mary‟s were experiencing difficulty in moving the Kirton Stirling chairs (pictured above). These chairs are used to transport elderly patients from one location to another. ...

Public support for medical research in the 21st century.

Science.gov (United States)

Smith, P M

2000-01-01

Key public policies that have contributed to the rise of modern medical research in the 20th Century are reviewed, focusing especially on the United States and the post-World War II period. Drawing on this history, the question is posed: "Are these policies sufficient to insure vigorous medical research in the 21st Century?" Although radical policy changes are not needed, several proposals for policy and medical research portfolio redirection are offered, including a rebalancing of public supported research in all fields of science that contribute to medical advances. Medical research must also invest in a national and international information infrastructure that will allow the linking of researchers, clinical experimenters, practicing physicians, and the public in ways heretofore not imagined. Medical researchers must be leaders and advocates for the whole research enterprise in the 21st Century.

Multidimensional Space-Time Methodology for Development of Planetary and Space Sciences, S-T Data Management and S-T Computational Tomography

Science.gov (United States)

Andonov, Zdravko

This R&D represent innovative multidimensional 6D-N(6n)D Space-Time (S-T) Methodology, 6D-6nD Coordinate Systems, 6D Equations, new 6D strategy and technology for development of Planetary Space Sciences, S-T Data Management and S-T Computational To-mography. . . The Methodology is actual for brain new RS Microwaves' Satellites and Compu-tational Tomography Systems development, aimed to defense sustainable Earth, Moon, & Sun System evolution. Especially, extremely important are innovations for monitoring and protec-tion of strategic threelateral system H-OH-H2O Hydrogen, Hydroxyl and Water), correspond-ing to RS VHRS (Very High Resolution Systems) of 1.420-1.657-22.089GHz microwaves. . . One of the Greatest Paradox and Challenge of World Science is the "transformation" of J. L. Lagrange 4D Space-Time (S-T) System to H. Minkovski 4D S-T System (O-X,Y,Z,icT) for Einstein's "Theory of Relativity". As a global result: -In contemporary Advanced Space Sciences there is not real adequate 4D-6D Space-Time Coordinate System and 6D Advanced Cosmos Strategy & Methodology for Multidimensional and Multitemporal Space-Time Data Management and Tomography. . . That's one of the top actual S-T Problems. Simple and optimal nD S-T Methodology discovery is extremely important for all Universities' Space Sci-ences' Education Programs, for advances in space research and especially -for all young Space Scientists R&D!... The top ten 21-Century Challenges ahead of Planetary and Space Sciences, Space Data Management and Computational Space Tomography, important for successfully de-velopment of Young Scientist Generations, are following: 1. R&D of W. R. Hamilton General Idea for transformation all Space Sciences to Time Sciences, beginning with 6D Eukonal for 6D anisotropic mediums & velocities. Development of IERS Earth & Space Systems (VLBI; LLR; GPS; SLR; DORIS Etc.) for Planetary-Space Data Management & Computational Planetary & Space Tomography. 2. R&D of S. W. Hawking Paradigm for 2D

The significance of early post-exercise ST segment normalization.

Science.gov (United States)

Chow, Rudy; Fordyce, Christopher B; Gao, Min; Chan, Sammy; Gin, Kenneth; Bennett, Matthew

2015-01-01

The persistence of ST segment depression in recovery signifies a strongly positive exercise treadmill test (ETT). However, it is unclear if early recovery of ST segments portends a similar prognosis. We sought to determine if persistence of ST depression into recovery correlates with ischemic burden based on myocardial perfusion imaging (MPI). This was a retrospective analysis of 853 consecutive patients referred for exercise MPI at a tertiary academic center over a 24-month period. Patients were stratified into three groups based on the results of the ETT: normal (negative ETT), persistence (positive ETT with >1mm ST segment depression at 1minute in recovery) and early normalization (positive ETT with normalization, while 105 patients met criteria for persistence. The persistence group had a significantly greater SSS (8.48±7.77) than both the early normalization (4.34±4.98, pnormal (4.47±5.31, pnormalization and normal groups were not statistically different and met the prespecified non-inferiority margin (mean difference 0.12, -0.66=lower 95% CI, pnormal and 7.4% of early normalization groups. Among patients with an electrically positive ETT, recovery of ST segment depression within 1minute was associated with a lower SSS than patients with persistence of ST depression beyond 1minute. Furthermore, early ST segment recovery conferred a similar SSS to patients with a negative ETT. These results suggest that among patients evaluated for chest pain with a positive ETT, early recovery of the ST segment during recovery is associated with a significantly less ischemic burden on subsequent MPI and thus may represent a false positive finding in exercise treadmill testing. Copyright © 2015 Elsevier Inc. All rights reserved.

Serum soluble ST2 is associated with ER-positive breast cancer

International Nuclear Information System (INIS)

Lu, Da-peng; Zhou, Xiang-yu; Yao, Lu-tian; Liu, Cai-gang; Ma, Wei; Jin, Feng; Wu, Yun-fei

2014-01-01

ST2, a member of the interleukin (IL)-1receptor family, regulates Th1/Th2 immune responses in autoimmune and inflammatory conditions. However, the role of ST2 signaling in tumor growth and metastasis of breast cancers has not been investigated. This study investigated the possible role of soluble ST2 (sST2) in breast cancer. The serum levels of IL-33, sST2, and vascular endothelial growth factor (VEGF) in 150 breast cancer patients and 90 healthy women were measured by enzyme-linked immunosorbent assay. Estrogen receptor(ER), progesterone receptor, human epithelial receptor (HER)-2, and cell cycle regulated protein Ki-67 were measured. Clinical stage, tumor size, lymph node metastasis, and histological type were also recorded. The serum levels of sST2, IL-33, and VEGF were significantly higher in breast cancer patients than in the control group (P < 0.05, each). Serum sST2 levels in ER-positive breast cancer patients were significantly associated with age, histological type, clinical stage, tumor size, and Ki-67 status (P < 0.05, each). Moreover, the serum levels of IL-33 and sST2 in breast cancers significantly correlated with VEGF levels (IL-33: r = 0.375, P < 0.0001; sST2: r = 0.164, P = 0.045). Serum levels of sST2, IL-33, and VEGF decreased after modified radical mastectomy in ER-positive breast cancers. Serum levels of IL-33, sST2, and VEGF and clinicopathological factors were not significantly correlated with disease-free survival and overall survival of ER-positive breast cancer women during follow-up. Serum sST2 levels in ER-positive breast cancer patients are significantly associated with factors that indicate poor prognosis

78 FR 22416 - Amendment of Class E Airspace; St. Helena, CA

Science.gov (United States)

2013-04-16

... more above the surface of the earth. * * * * * AWP CA E5 St. Helena, CA [Amended] Napa County Fire... the name of the heliport listed in the Class E airspace for St. Helena, CA. St. Helena Fire Department Heliport has been changed to Napa County Fire Department Heliport, St. Helena, CA. This action does not...

Impaired Glucose Tolerance in Healthy Men Treated with St. John's Wort

DEFF Research Database (Denmark)

Stage, Tore Bjerregaard; Damkier, Per; Christensen, Mette Marie Hougaard

2016-01-01

The purpose of this study was to examine if the over-the-counter herbal medicinal plant St. John's wort affects glucose tolerance in healthy men. To do this, we included 10 healthy men who were examined by a 2-hr oral glucose tolerance test on three occasions; A: Baseline, B: After 21 days...

Environmental Assessment on the leasing of the Strategic Petroleum Reserve, St. James Terminal, St. James Parish, Louisiana

International Nuclear Information System (INIS)

1995-01-01

The US Department of Energy (DOE) proposes to lease the Strategic Petroleum Reserve's (SPR) St. James Terminal to private industry. The St. James Terminal consists of six storage tanks, a pumping station, two maine docks and ancillary facilities. DOE believes that the St. James Terminal presents an opportunity to establish a government- industry arrangement that could more effectively use this asset to serve the nations's oil distribution needs, reduce the operational cost of the SPR, and provide a source of revenue for the Government. DOE solicited interest in leasing its distribution facilities in a notice published March 16, 1994. In response, industry has expressed interest in leasing the St. James Terminal, as well as several DOE pipelines, to enhance the operation of its own facilities or to avoid having to construct new ones. Under such a lease, industry use would be subordinate to DOE use in the event of a national energy emergency. This Environmental Assessment describes the proposed leasing operation, its alternatives, and potential environmental impacts. Based on this analyses, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act (NEPA) OF 1969 and has issued the Finding of No Significant Impact (FONSI)

Danmarks Største Fossiler

DEFF Research Database (Denmark)

Lindow, Bent Erik Kramer; Cuny, Gilles Guy Roger

2008-01-01

For 8 millioner år siden myldrede Nordsøen af en mangfoldighed af hajer, hvaler, havskildpadder og sæler, mange flere end i dag. Blandt dem finder man Danmarks største fossiler som er udstillet på Museum Sønderjylland - Naturhistorie og Palæontologi i Gram.......For 8 millioner år siden myldrede Nordsøen af en mangfoldighed af hajer, hvaler, havskildpadder og sæler, mange flere end i dag. Blandt dem finder man Danmarks største fossiler som er udstillet på Museum Sønderjylland - Naturhistorie og Palæontologi i Gram....

IAEA safeguards for the 21st century

International Nuclear Information System (INIS)

1999-01-01

The publication includes the lectures held during the seminar on IAEA safeguards for the 21st century. The topics covered are as follows: the nuclear non-proliferation regime; Legal instruments related to the application of safeguards; multilateral nuclear export controls; physical protection and its role in nuclear non-proliferation; the evolution of safeguards; basis for the strengthening of safeguards; information required from states, including 'small quantities protocol'; processing and evaluation of new information for strengthened safeguards; additional physical access and new technologies for strengthened safeguards; equipping the IAEA Inspectorate with new skills; achievements to date the strengthened safeguards; complement of regional non-proliferation arrangements in international nuclear verification; promotion of transparency through Korean experience; and the future prospects of safeguards

Nuclear Power in the 21st Century

International Nuclear Information System (INIS)

Amano, Yukiya

2013-01-01

The International Atomic Energy Agency helps its Member States to use nuclear technology for a broad range of peaceful purposes, one of the most important of which is generating electricity. The accident at the Fukushima Daiichi nuclear power plant in Japan in March 2011 caused anxiety about nuclear safety throughout the world and raised questions about the future of nuclear power. Two years on, it is clear that the use of nuclear power will continue to grow in the coming decades, although growth will be slower than was anticipated before the accident. Many countries with existing nuclear power programmes plan to expand them. Many new countries, both developed and developing, plan to introduce nuclear power. The factors contributing to this growing interest include increasing global demand for energy, as well as concerns about climate change, volatile fossil fuel prices, and security of energy supply. It will be difficult for the world to achieve the twin goals of ensuring sustainable energy supplies and curbing greenhouse gases without nuclear power. The IAEA helps countries that opt for nuclear power to use it safely and securely. Countries that have decided to phase out nuclear power will have to deal with issues such as plant decommissioning, remediation, and waste management for decades to come. The IAEA also assists in these areas. I am grateful to the Russian Federation for hosting the 2013 International Ministerial Conference on Nuclear Power in the 21st Century in St Petersburg in June. This timely conference provides a valuable opportunity to take stock of nuclear power in the wake of the Fukushima Daiichi accident. A high level of public confidence in the safety of nuclear power is essential for the future of the sector. Much valuable work has been done in the past two years to improve safety. But much remains to be done. It is vitally important that the momentum is maintained and that everything is done to ensure that nuclear power is as safe as humanly

Diagnostics of ST Plasmas in NSTX: Challenges and Opportunities

International Nuclear Information System (INIS)

Johnson, D.; Efthimion, P.; Foley, J.; Jones, B.; Mazzucato, E.; Park, H.; Taylor, G.; Levinton, F.; Luhmann, N.

2001-01-01

This paper will highlight some of the challenges and opportunities present in the diagnosis of spherical torus (ST) plasmas on the National Spherical Torus Experiment (NSTX) and discuss the corresponding diagnostic development that is presently underway. After a brief description of diagnostic systems currently installed, examples of ST-specific diagnostic challenges will be highlighted, as will another case, where the ST configuration offers opportunities for new measurements

Detection of ST772 Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus (Bengal Bay clone and ST22 S. aureus isolates with a genetic variant of elastin binding protein in Nepal

Directory of Open Access Journals (Sweden)

R.H. Pokhrel

2016-05-01

Full Text Available Genetic characteristics were analysed for recent clinical isolates of methicillin-resistant and -susceptible Staphylococcus aureus (MRSA and MSSA respectively in Kathmandu, Nepal. MRSA isolates harbouring Panton-Valentine leukocidin (PVL genes were classified into ST1, ST22 and ST88 with SCCmec-IV and ST772 with SCCmec-V (Bengal Bay clone, while PVL-positive MSSA into ST22, ST30 and ST772. ST22 isolates (PVL-positive MRSA and MSSA, PVL-negative MRSA possessed a variant of elastin binding protein gene (ebpS with an internal deletion of 180 bp, which was similar to that reported for ST121 S. aureus previously outside Nepal. Phylogenetic analysis indicated that the ebpS variant in ST22 might have occurred independently of ST121 strains. This is the first report of ST772 PVL-positive MRSA in Nepal and detection of the deletion variant of ebpS in ST22 S. aureus.

ST Safety What's on?

CERN Document Server

Jacot, C

2001-01-01

Du premier coup de pioche jusqu'à la mise en place de la tente abritant le buffet offert lors de la cérémonie d'achèvement d'un projet, la division ST est sur les rangs et apporte son savoir faire. Ces projets nombreux et pluridisciplinaires sont étudiés, se réalisent, s'exploitent et font l'objet de maintenance jusqu'à leur démantèlement. Durant leurs cycles de vie, la division ST avance les compétences professionnelles spécifiques à chaque corps de métiers incluant le recours à de nombreux contrats avec des entreprises extérieures pour réaliser les travaux sur les sites du CERN. Pour en conserver la maîtrise, la division ST applique une gestion de projet, une assurance de la qualité et s'attache tout particulièrement à la sécurité, à la réglementation, à la prévention des risques et la gestion de ceux-ci. Sous la supervision du DSO, un ensemble de procédures et de démarches a été développé afin de faciliter les tâches du maître d'ouvrage et des entreprises contractantes, c...

Simulation of ground-water flow in the St. Peter aquifer in an area contaminated by coal-tar derivatives, St. Louis Park, Minnesota. Water Resources Investigation

International Nuclear Information System (INIS)

Lorenz, D.L.; Stark, J.R.

1990-01-01

A model constructed to simulate ground-water flow in part of the Prairie du Chien-Jordan and St. Peter aquifers, St. Louis Park, Minnesota, was used to test hypotheses about the movement of ground water contaminated with coal-tar derivatives and to simulate alternatives for reducing the downgradient movement of contamination in the St. Peter aquifer. The model, constructed for a previous study, was applied to simulate the effects of current ground-water withdrawals on the potentiometric surface of the St. Peter aquifer. Model simulations predict that the multiaquifer wells have the potential to limit downgradient migration of contaminants in the St. Peter aquifer caused by cones of depression created around the multiaquifer wells. Differences in vertical leakage to the St. Peter aquifer may exist in areas of bedrock valleys. Model simulations indicate that these differences are not likely to affect significantly the general patterns of ground-water flow

Simulation of hydrodynamics, water quality, and lake sturgeon habitat volumes in Lake St. Croix, Wisconsin and Minnesota, 2013

Science.gov (United States)

Smith, Erik A.; Kiesling, Richard L.; Ziegeweid, Jeffrey R.; Elliott, Sarah M.; Magdalene, Suzanne

2018-01-05

Lake St. Croix is a naturally impounded, riverine lake that makes up the last 40 kilometers of the St. Croix River. Substantial land-use changes during the past 150 years, including increased agriculture and urban development, have reduced Lake St. Croix water-quality and increased nutrient loads delivered to Lake St. Croix. A recent (2012–13) total maximum daily load phosphorus-reduction plan set the goal to reduce total phosphorus loads to Lake St. Croix by 20 percent by 2020 and reduce Lake St. Croix algal bloom frequencies. The U.S. Geological Survey, in cooperation with the National Park Service, developed a two-dimensional, carbon-based, laterally averaged, hydrodynamic and water-quality model, CE–QUAL–W2, that addresses the interaction between nutrient cycling, primary production, and trophic dynamics to predict responses in the distribution of water temperature, oxygen, and chlorophyll a. Distribution is evaluated in the context of habitat for lake sturgeon, including a combination of temperature and dissolved oxygen conditions termed oxy-thermal habitat.The Lake St. Croix CE–QUAL–W2 model successfully reproduced temperature and dissolved oxygen in the lake longitudinally (from upstream to downstream), vertically, and temporally over the seasons. The simulated water temperature profiles closely matched the measured water temperature profiles throughout the year, including the prediction of thermocline transition depths (often within 1 meter), the absolute temperature of the thermocline transitions (often within 1.0 degree Celsius), and profiles without a strong thermocline transition. Simulated dissolved oxygen profiles matched the trajectories of the measured dissolved oxygen concentrations at multiple depths over time, and the simulated concentrations matched the depth and slope of the measured concentrations.Additionally, trends in the measured water-quality data were captured by the model simulation, gaining some potential insights into the

Moving towards first science with the St. George recoil separator

Science.gov (United States)

Meisel, Zachary; Berg, G. P. A.; Gilardy, G.; Moran, M.; Schmitt, J.; Seymour, C.; Stech, E.; Couder, M.

2015-10-01

The St. George recoil mass separator has recently been coupled to the 5MV St. Ana accelerator at the University of Notre Dame's Nuclear Science Lab. St. George is a unique tool designed to measure radiative alpha-capture reactions for nuclei up to A = 40 in inverse kinematics in order to directly obtain cross sections required for astrophysical models of stellar and explosive helium burning. Commissioning of St. George is presently taking place with primary beams of hydrogen, helium, and oxygen. In this presentation, results will be shown for the measured energy acceptance of St. George, which compare favorably to COSY results when employing the calculated optimal ion-optical settings. Additionally, future plans will be discussed, such as assessing the angular acceptance of St. George and the re-integration of HiPPO at the separator target position to provide a dense, windowless helium gas-jet target. The material presented in this work is partially supported by the National Science Foundation Grant No. 1419765.

St. Bernard Parish : la crise d’un territoire suburbain St. Bernard Parish, the crisis of a suburban territory

Directory of Open Access Journals (Sweden)

Jean-Marc Zaninetti

2009-04-01

Full Text Available Situé à l’est de La Nouvelle-Orléans, St. Bernard Parish est l’un des territoires les plus vulnérables au risque d’ondes de tempêtes de toute la région métropolitaine. Après avoir été ravagée par le cyclone Katrina en 2005, St. Bernard peine à se redresser et montre le plus faible niveau de reprise de toute la région du Golfe du Mexique frappée par Katrina. De plus, la reconstruction est freinée par des polémiques virulentes qui nous rappellent les pires années des tensions raciales des années 1960. Cet article s’intéresse aux relations supposées entre les fragmentations urbaines et la faculté d’adaptation aux risques naturels. L’étude du cas de St. Bernard illustre la force d’inertie des territoires et comment de vieilles querelles ville-banlieue affaiblissent la résilience urbaine.Located east of New Orleans, St. Bernard Parish is one of the most vulnerable parts of the greater New Orleans metropolitan area to storm surges. After having been devastated by Hurricane Katrina in 2005, St. Bernard still struggles to recover from the storm, and displays the lowest recovery level of the entire Katrina-hit Gulf Coast area so far. Moreover, reconstruction is hampered by loud polemics that remind us of the worst years of racial polarization during the 1960’s. This paper explores the possible linkage between urban fragmentations and adaptive capacity to natural hazard. The St. Bernard case-study illustrates the strength of path dependency, and how long-entrenched suburb-central city mistrust hampers urban resilience.

Current status of non-native fish species in the St. Louis River estuary

Science.gov (United States)

The fish community of the St. Louis River estuary is well characterized, thanks to fishery assessment and invasive species early detection monitoring by federal, state, and tribal agencies. This sampling includes long-standing adult/juvenile fish surveys, larval fish surveys beg...

Analyse of Maintenance Cost in ST

CERN Document Server

Jenssen, B W

2001-01-01

An analyse has been carried out in ST concerning the total costs for the division. Even though the target was the maintenance costs in ST, the global budget over has been analysed. This has been done since there is close relation between investments & consolidation and the required level for maintenance. The purpose of the analyse was to focus on maintenance cost in ST as a ratio of total maintenance costs over the replacement value of the equipment, and to make some comparisons with other industries and laboratories. Families of equipment have been defined and their corresponding ratios calculated. This first approach gives us some "quantitative" measurements. This analyse should be combined with performance indicators (more "qualitative" measurements) that are telling us how well we are performing. This will help us in defending our budget, make better priorities, and we will satisfy the requirements from our external auditors.

Church of St. Peter and Paul in the village under Kopaonik

Directory of Open Access Journals (Sweden)

Raičević Slobodan

2009-01-01

Full Text Available In the border of the municipality towards Kosovo, Kuršumlija preserved the St. Cemetery's church of Peter and Paul in village Lukovo near the famous rehabilitation center Lukovo's spa. Church is one nave with a semicircular apse at the east vaults with semicircular arch reinforced with cross sec­tion curve, which relies on a few strong pilasters placed inside long walls. According to folk tradition the church was built in the middle ages and served to diggers and foundries of lead ores of King Milutin. Upon termination of exploitation ore the church neglected and in the 19th century it suffered its first renewal 1871st and another 1895th year. Saved epigraphic inscription with carved year of renewal (1895th, icons and wall decor of the church provide information about reliably judging its recent history and artistic value. Soon after the bricklaying work 1895th Church has received from the altar wall of icons, and after that, and mural painting small artistic value. The crown of the vault is painted Pantocrator, about whose performances are painted scenes of the Transfiguration, Ascension of Christ, Vavedenje and Entry into Jerusalem. On the western wall are shown the Dormition of the Mother of God and in the first zone are shown standing figures of Sts. Constantine and Helena, St. Simon Mir refills and St. Prince Lazar - kefaloforos. On the triumphal arch are Old. Testament scenes of hospitality and sacrifice of Abraham and in the apse bust of God Savaot. In the zone of standing figures are shown Sts. Druid, St. Czar Uroš and St. King Stephen, St. Sunday, St. Petka, St. Procopius, and St. George. From the figures standing at the altar of bishops are shown St. John Chrysostom, St. Sava Serbian, St. Basil the Great and St. Athanasius. There was saved the altar compartments with icons. At the czar's gate are shown Blagovesti and in the order of main icons: Christ Almighty, Mother of God with Christ, St. John the Forerunner, icons of patron St

Situation Reports--Barbados, Canada, Papua and New Guinea, St. Vincent, Surinam.

Science.gov (United States)

International Planned Parenthood Federation, London (England).

Data relating to population and family planning in six countries are presented in these situation reports. Countries included are Barbados, Canada, Papua and New Guinea, St. Vincent, and Surinam. Information is provided in the following areas where appropriate and if it is available: (1) statistics on population, birth and death rates, G. N. P.,…

Principal Component Surface (2011) for St. Thomas East End Reserve, St. Thomas

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a 0.3x0.3 meter principal component analysis (PCA) surface for areas the St. Thomas East End Reserve (STEER) in the U.S. Virgin Islands (USVI)....

Clinical significance of stress-induced ST segment changes in patients with previous myocardial infarction

International Nuclear Information System (INIS)

Futagami, Yasuo; Hamada, Masayuki; Makino, Katsutoshi; Ichikawa, Takehiko; Konishi, Tokuji

1984-01-01

To explain the clinical significance of stress(st)-induced ST-segment (ST) changes postinfarction, 93 patients with previous myocardial infarction (MI) were performed st- 201 Tl myocardial single photon emission computed tomography (SPECT) and compared ST changes with SPECT, coronary arteriographic and left ventriculographic findings. 30 out of 93 cases (32%) had ST depression, 20 (21.5%) had ST elevation, 9 (10%) had both ST depression and elevation and remaining 34 (36.5 %) had no significant ST changes. In single vessel disease, ST depression were noted in 29% (12/42), while in multivessel disease, 53% (27/51). 35 out of 39 cases (90%) with ST depression had transient perfusion defect but no apparent relation was noted between location of ST depression on ECG and region of transient perfusion defect in SPECT. All of 28 cases with ST elevation were noted in anterior MI cases, and 26 out of these showed severe LV wall motion abnormality in contrast left ventriculography and broad anterior permanent defect in SPECT. Only 15 cases (54%) showed slight redistribution. Thus, we conclude that in patients with previous MI, st-induced ST depression seems to reflect myocardial ischemia and ST elevation possibly related abnormal LV wall motion. (author)

DOE pollution prevention in the 21st century. Proceedings

Energy Technology Data Exchange (ETDEWEB)

1996-12-31

This CD-ROM contains the proceedings from the DOE Pollution Prevention in the 21st Century Conference XII held July 9-11, 1996. Topics included model facilities, federal and NEPA stakeholders, microchemistry, source 4 solvents and reduction, education and outreach planning, return on investment, energy management, decontamination and decommissioning, planning and regulations, environmental restoration, solid waste, recycling, affirmative procurement in the executive branch, construction and demolition, international and ISO 14000, and poster sessions.

DOE pollution prevention in the 21st century. Proceedings

International Nuclear Information System (INIS)

1996-01-01

This CD-ROM contains the proceedings from the DOE Pollution Prevention in the 21st Century Conference XII held July 9-11, 1996. Topics included model facilities, federal and NEPA stakeholders, microchemistry, source 4 solvents and reduction, education and outreach planning, return on investment, energy management, decontamination and decommissioning, planning and regulations, environmental restoration, solid waste, recycling, affirmative procurement in the executive branch, construction and demolition, international and ISO 14000, and poster sessions

ST-segment depression in aVR as a predictor of culprit artery in acute inferior wall ST-segment elevation myocardial infarction

Directory of Open Access Journals (Sweden)

Ahmed Hafez el-neklawy

2014-03-01

Conclusions: ST depression in aVR is common in patients with LCX-related acute inferior myocardial infarction. The ST changes in this lead are associated with an excellent specificity and a good sensitivity in differentiating LCX from RCA as the IRA.

At stå i det åbne

DEFF Research Database (Denmark)

Hansen, Finn Thorbjørn

Bogen At stå i det åbne: Dannelse gennem filosofisk undren og nævær er en pædagogisk-filosofisk undersøgelse af, hvad det vil sige at stå i et "undringsfællesskab" i en undervisnings- og vejledningssituation. Ved at trække på den eksistentiel-fænomenologiske og filosofisk-hermeneutiske forskning ...

Predictive value of the baseline electrocardiogram ST-segment pattern in cardiogenic shock: Results from the CardShock Study.

Science.gov (United States)

Javanainen, Tuija; Tolppanen, Heli; Lassus, Johan; Nieminen, Markku S; Sionis, Alessandro; Spinar, Jindrich; Silva-Cardoso, José; Greve Lindholm, Matias; Banaszewski, Marek; Harjola, Veli-Pekka; Jurkko, Raija

2018-05-30

The most common aetiology of cardiogenic shock (CS) is acute coronary syndrome (ACS), but even up to 20%-50% of CS is caused by other disorders. ST-segment deviations in the electrocardiogram (ECG) have been investigated in patients with ACS-related CS, but not in those with other CS aetiologies. We set out to explore the prevalence of different ST-segment patterns and their associations with the CS aetiology, clinical findings and 90-day mortality. We analysed the baseline ECG of 196 patients who were included in a multinational prospective study of CS. The patients were divided into 3 groups: (a) ST-segment elevation (STE). (b) ST-segment depression (STDEP). (c) No ST-segment deviation or ST-segment impossible to analyse (NSTD). A subgroup analysis of the ACS patients was conducted. ST-segment deviations were present in 80% of the patients: 52% had STE and 29% had STDEP. STE was associated with the ACS aetiology, but one-fourth of the STDEP patients had aetiology other than ACS. The overall 90-day mortality was 41%: in STE 47%, STDEP 36% and NSTD 33%. In the multivariate mortality analysis, only STE predicted mortality (HR 1.74, CI 95 1.07-2.84). In the ACS subgroup, the patients were equally effectively revascularized, and no differences in the survival were noted between the study groups. ST-segment elevation is associated with the ACS aetiology and high mortality in the unselected CS population. If STE is not present, other aetiologies must be considered. When effectively revascularized, the prognosis is similar regardless of the ST-segment pattern in ACS-related CS. © 2018 Wiley Periodicals, Inc.

Three centuries of multi-storied St. Petersburg

Science.gov (United States)

Lavrov, Leonid; Perov, Fedor; Eremeeva, Aleksandra; Temnov, Vladimir

2018-03-01

The article is devoted to assessment of the role of high-rise buildings in the St. Petersburg historic city's ensemble. Features of formation of city architectural look, the conditions of city typical silhouette's appearance which is characterized by the contrast of a small number of high-rise structures with a low horizontal mass building are observed. The consequences of the emergence of a significant number of great height buildings, the silhouette of which conflicts with the traditional St. Petersburg landscape's compositional principles, are analyzed. The economic reasons of high-rise construction of residential and office buildings are given. The conclusions about the prospects of St. Petersburg high-rise construction in the light of city-building and economic factors are made.

Orthodoxy and Islam. St. Cyril and St. Gregory Palamas in Dialogue with Muslims

Directory of Open Access Journals (Sweden)

Grzegorz Makal

2014-12-01

Full Text Available The purpose of this study is to present the role of the Holy Fathers in the dialogue between the Orthodox and theMuslims. The first part of the article talks about the mission of St. Cyril in Baghdad Caliphate in historical perspective. Itdeals with his dialogue with Islam and presents an analysis of the arguments used by both sides. In the second part I talkabout the dialogue of St. Gregory Palamas with Muslims in the context of the mission of Cyril, comparing the argumentsof both fathers and their attitudes towards the dialogue with Islam. Finally, the theory of the “biblical roots of Europe” isaddressed, drawing on the example of the abovementioned Holy Fathers. In the article some excerpts from Palamas’worksare published in Polish for the first time.

Characterization of StABF1, a stress-responsive bZIP transcription factor from Solanum tuberosum L. that is phosphorylated by StCDPK2 in vitro.

Science.gov (United States)

Muñiz García, María Noelia; Giammaria, Verónica; Grandellis, Carolina; Téllez-Iñón, María Teresa; Ulloa, Rita María; Capiati, Daniela Andrea

2012-04-01

ABF/AREB bZIP transcription factors mediate plant abiotic stress responses by regulating the expression of stress-related genes. These proteins bind to the abscisic acid (ABA)-responsive element (ABRE), which is the major cis-acting regulatory sequence in ABA-dependent gene expression. In an effort to understand the molecular mechanisms of abiotic stress resistance in cultivated potato (Solanum tuberosum L.), we have cloned and characterized an ABF/AREB-like transcription factor from potato, named StABF1. The predicted protein shares 45-57% identity with A. thaliana ABFs proteins and 96% identity with the S. lycopersicum SlAREB1 and presents all of the distinctive features of ABF/AREB transcription factors. Furthermore, StABF1 is able to bind to the ABRE in vitro. StABF1 gene is induced in response to ABA, drought, salt stress and cold, suggesting that it might be a key regulator of ABA-dependent stress signaling pathways in cultivated potato. StABF1 is phosphorylated in response to ABA and salt stress in a calcium-dependent manner, and we have identified a potato CDPK isoform (StCDPK2) that phosphorylates StABF1 in vitro. Interestingly, StABF1 expression is increased during tuber development and by tuber-inducing conditions (high sucrose/nitrogen ratio) in leaves. We also found that StABF1 calcium-dependent phosphorylation is stimulated by tuber-inducing conditions and inhibited by gibberellic acid, which inhibits tuberization.

Environmental Assessment on the leasing of the Strategic Petroleum Reserve, St. James Terminal, St. James Parish, Louisiana

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-01-01

The US Department of Energy (DOE) proposes to lease the Strategic Petroleum Reserve`s (SPR) St. James Terminal to private industry. The St. James Terminal consists of six storage tanks, a pumping station, two maine docks and ancillary facilities. DOE believes that the St. James Terminal presents an opportunity to establish a government- industry arrangement that could more effectively use this asset to serve the nations`s oil distribution needs, reduce the operational cost of the SPR, and provide a source of revenue for the Government. DOE solicited interest in leasing its distribution facilities in a notice published March 16, 1994. In response, industry has expressed interest in leasing the St. James Terminal, as well as several DOE pipelines, to enhance the operation of its own facilities or to avoid having to construct new ones. Under such a lease, industry use would be subordinate to DOE use in the event of a national energy emergency. This Environmental Assessment describes the proposed leasing operation, its alternatives, and potential environmental impacts. Based on this analyses, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act (NEPA) OF 1969 and has issued the Finding of No Significant Impact (FONSI).

Cloning and characterization of a potato StAN11 gene involved in anthocyanin biosynthesis regulation.

Science.gov (United States)

Li, Wang; Wang, Bing; Wang, Man; Chen, Min; Yin, Jing-Ming; Kaleri, Ghullam Murtaza; Zhang, Rui-Jie; Zuo, Tie-Niu; You, Xiong; Yang, Qing

2014-04-01

Anthocyanins are a class of products of plant secondary metabolism and are responsible for tubers color in potato. The biosynthesis of anthocyanins is a complex biological process, in which multiple genes are involved including structural genes and regulatory genes. In this study, StAN11, a WD40-repeat gene, was cloned from potato cultivar Chieftain (Solanum tuberosum L.). StAN11 (HQ599506) contained no intron and its open reading frame (ORF) was 1,029 bp long, encoding a putative protein of 342 amino acids. In order to verify its role in anthocyanin biosynthesis, StAN11 was inserted behind the CaMV-35S promoter of pCMBIA1304 and the recombination vector was introduced into the potato cultivar Désirée plants by Agrobacterium-mediated transformation. The color of transgenic tuber skin was significantly deepened, compared to the wild-type control, which was highly consistent with the accumulation of anthocyanin and expression of StAN11 in transgenic lines tuber skin. Further analysis on the expression of Flavonone-3-hydroxylase (F3H), Dihydroflavonol reductase (DFR), Anthocyanidin synthase (ANS), and Flavonoid 3-O-glucosyl transferase (3GT) in transgenic plants revealed that only DFR was upregulated. This result suggested that StAN11 regulated anthocyanin biosynthesis in potato by controlling DFR expression and accumulation of anthocyanin could be increased through overexpression of StAN11 in the tubers with the genetic background of anthocyanin biosynthesis. © 2013 Institute of Botany, Chinese Academy of Sciences.

Carl Størmer Auroral Pioneer

CERN Document Server

Egeland, Alv

2013-01-01

This biography summarizes the seminal contributions to auroral and space science of Carl Størmer (1874 - 1957). He was the first to develop precise photographic methods to calculate heights and morphologies of diverse auroral forms during four solar cycles. Størmer independently devised numerical techniques to determine the trajectories of high-energy charged particles allowed and forbidden in the Earth’s magnetic field. His theoretical analyses explained cosmic ray access to the upper atmosphere, 20 years before they were identified by other scientists. Størmer’s crowning achievement, “The Polar Aurora,” published when he was 81 years old, stands to this day as a regularly cited guide in graduate-level courses on space physics.   The authors present the life of this prodigious scientist in relation to the cultural life of early 20th century in Norway and to the development of the space sciences in the post-Sputnik era.

GeoTIFF of 3x3 m Bathymetry for St. Thomas & St. John, 2011, UTM 20N NAD83 (NCEI Accession 0131858)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 3x3 meter resolution bathymetric surface for an area of shallow seabed surrounding St. Thomas and St....

21st Century leadership skills for learning networks

NARCIS (Netherlands)

Basten, Floor; Evers, Arnoud; Geijsel, Femke; Vermeulen, Marjan

2018-01-01

Ultimate goal: to prepare pupils for a life in a society that requires 21st century skills and actions Immediate focus: teachers and principals develop 21st century skills in the practice of their work → together with researchers principals co-create tools to support teacher learning.

Geophysical data collected from the St. Clair River between Michigan and Ontario, Canada (2008-016-FA)

Science.gov (United States)

Denny, Jane F.; Foster, D.S.; Worley, C.R.; Irwin, Barry J.

2011-01-01

In 2008, the U.S. Geological Survey (USGS), Woods Hole Coastal and Marine Science Center (WHCMSC), in cooperation with the U.S. Army Corps of Engineers conducted a geophysical and sampling survey of the riverbed of the Upper St. Clair River between Port Huron, Mich., and Sarnia, Ontario, Canada. The objectives were to define the Quaternary geologic framework of the riverbed of the St. Clair River to evaluate the relationship between morphologic change of the riverbed and underlying stratigraphy. This report presents the geophysical and sample data collected from the St. Clair River, May 29-June 6, 2008, as part of the International Upper Great Lakes Study, a 5-year project funded by the International Joint Commission of the United States and Canada to examine whether physical changes in the St. Clair River are affecting water levels within upper Great Lakes, to assess regulation plans for outflows from Lake Superior, and to examine the potential effect of climate change on the Great Lakes water levels (http://www.iugls.org). This document makes available the data that were used in a separate report, U.S. Geological Survey Open-File Report 2009-1137, which detailed the interpretations of the Quaternary geologic framework of the region. This report includes a description of the high-resolution acoustic and sediment-sampling systems that were used to map the morphology, surficial sediment distribution, and underlying geology of the Upper St. Clair River during USGS field activity 2008-016-FA (http://quashnet.er.usgs.gov/cgi-bin/datasource/public_ds_info.pl?fa=2008-016-FA). Video and photographs of the riverbed were also collected and are included in this data release. Future analyses will be focused on substrate erosion and its effects on river-channel morphology and geometry. Ultimately, the International Upper Great Lakes Study will attempt to determine where physical changes in the St. Clair River affect water flow and, subsequently, water levels in the Upper Great

St. Louis encephalitis virus possibly transmitted through blood transfusion-Arizona, 2015.

Science.gov (United States)

Venkat, Heather; Adams, Laura; Sunenshine, Rebecca; Krow-Lucal, Elisabeth; Levy, Craig; Kafenbaum, Tammy; Sylvester, Tammy; Smith, Kirk; Townsend, John; Dosmann, Melissa; Kamel, Hany; Patron, Roberto; Kuehnert, Matthew; Annambhotla, Pallavi; Basavaraju, Sridhar V; Rabe, Ingrid B

2017-12-01

St. Louis encephalitis virus is a mosquito-borne flavivirus that infrequently causes epidemic central nervous system infections. In the United States, blood donors are not screened for St. Louis encephalitis virus infection, and transmission through blood transfusion has not been reported. During September 2015, St. Louis encephalitis virus infection was confirmed in an Arizona kidney transplant recipient. An investigation was initiated to determine the infection source. The patient was interviewed, and medical records were reviewed. To determine the likelihood of mosquito-borne infection, mosquito surveillance data collected at patient and blood donor residences in timeframes consistent with their possible exposure periods were reviewed. To investigate other routes of exposure, organ and blood donor and recipient specimens were obtained and tested for evidence of St. Louis encephalitis virus infection. The patient presented with symptoms of central nervous system infection. Recent St. Louis encephalitis virus infection was serologically confirmed. The organ donor and three other organ recipients showed no laboratory or clinical evidence of St. Louis encephalitis virus infection. Among four donors of blood products received by the patient via transfusion, one donor had a serologically confirmed, recent St. Louis encephalitis virus infection. Exposure to an infected mosquito was unlikely based on the patient's minimal outdoor exposure. In addition, no St. Louis encephalitis virus-infected mosquito pools were identified around the patient's residence. This investigation provides evidence of the first reported possible case of St. Louis encephalitis virus transmission through blood product transfusion. Health care providers and public health professionals should maintain heightened awareness for St. Louis encephalitis virus transmission through blood transfusion in settings where outbreaks are identified. © 2017 AABB.

Ultrastructural and biochemical evidence for the presence of mature steroidogenic acute regulatory protein (StAR) in the cytoplasm of human luteal cells.

Science.gov (United States)

Sierralta, Walter D; Kohen, Paulina; Castro, Olga; Muñoz, Alex; Strauss, Jerome F; Devoto, Luigi

2005-10-20

The distribution of the steroidogenic acute regulatory protein (StAR) inside thecal and granulosa-lutein cells of human corpus luteum (CL) was assessed by immunoelectron microscopy. We found greater levels of StAR immunolabeling in steroidogenic cells from early- and mid-than in late luteal phase CL and lower levels in cells from women treated with a GnRH antagonist in the mid-luteal phase. Immunoelectron microscopy revealed significant levels of StAR antigen in the mitochondria and in the cytoplasm of luteal cells. The 30 kDa mature StAR protein was present in both mitochondria and cytosol (post-mitochondrial) fractions from homogenates of CL at different ages, whereas cytochrome c and mitochondrial HSP70 were detected only in the mitochondrial fraction. Therefore, we hypothesized that either appreciable processing of StAR 37 kDa pre-protein occurs outside the mitochondria, or mature StAR protein is selectively released into the cytoplasm after mitochondrial processing. The presence of mature StAR in the cytoplasm is consonant with the notion that StAR acts on the outer mitochondrial membrane to effect sterol import, and that StAR may interact with other cytoplasmic proteins involved in cholesterol metabolism, including hormone sensitive lipase.

Toxicology in the 21st century - Working our way towards a visionary reality

NARCIS (Netherlands)

Berg, N.; Wever, B.de; Fuchs, H.W.; Gaca, M.; Krul, C.A.M.; Roggen, E.L.

2011-01-01

In November 2009 the In Vitro Testing Industrial Platform (IVTIP) organized a meeting entitled '. Toxicology in the 21st century - working our way towards a visionary reality'. Participating delegates included scientists, key opinion leaders, developers and users of 3Rs-related tests and testing

CHST14/D4ST1 deficiency: New form of Ehlers-Danlos syndrome.

Science.gov (United States)

Kosho, Tomoki

2016-02-01

Carbohydrate sulfotransferase 14/dermatan 4-O-sulfotransferase-1 (CHST14/D4ST1) deficiency represents a specific form of Ehlers-Danlos syndrome (EDS) caused by recessive loss-of-function mutations in CHST14. The disorder has been independently termed "adducted thumb-clubfoot syndrome", "EDS, Kosho type", and "EDS, musculocontractural type". To date, 31 affected patients from 21 families have been described. Clinically, CHST14/D4ST1 deficiency is characterized by multiple congenital malformations (craniofacial features including large fontanelle, hypertelorism, short and downslanting palpebral fissures, blue sclerae, short nose with hypoplastic columella, low-set and rotated ears, high palate, long philtrum, thin upper lip vermilion, small mouth, and micro-retrognathia; multiple congenital contractures including adduction-flexion contractures and talipes equinovarus as well as other visceral or ophthalmological malformations) and progressive multisystem fragility-related complications (skin hyperextensibility, bruisability, and fragility with atrophic scars; recurrent dislocations; progressive talipes or spinal deformities; pneumothorax or pneumohemothorax; large subcutaneous hematomas; and diverticular perforation). Etiologically, multisystem fragility is presumably caused by impaired assembly of collagen fibrils resulting from loss of dermatan sulfate (DS) in the decorin glycosaminoglycan side chain that promotes electrostatic binding between collagen fibrils. This is the first reported human disorder that specifically affects biosynthesis of DS. Its clinical characteristics indicate that CHST14/D4ST1 and, more fundamentally, DS, play a critical role in fetal development and maintenance of connective tissues in multiple organs. Considering that patients with CHST14/D4ST1 deficiency develop progressive multisystem fragility-related manifestations, establishment of a comprehensive and detailed natural history and health-care guidelines as well as further elucidation

Fusion power core engineering for the ARIES-ST power plant

International Nuclear Information System (INIS)

Tillack, M.S.; Wang, X.R.; Pulsifer, J.; Malang, S.; Sze, D.K.; Billone, M.; Sviatoslavsky, I.

2003-01-01

ARIES-ST is a 1000 MWe fusion power plant based on a low aspect ratio 'spherical torus' (ST) plasma. The ARIES-ST power core was designed to accommodate the unique features of an ST power plant, to meet the top-level requirements of an attractive fusion energy source, and to minimize extrapolation from the fusion technology database under development throughout the world. The result is an advanced helium-cooled ferritic steel blanket with flowing PbLi breeder and tungsten plasma-interactive components. Design improvements, such as the use of SiC inserts in the blanket to extend the outlet coolant temperature range were explored and the results are reported here. In the final design point, the power and particle loads found in ARIES-ST are relatively similar to other advanced tokamak power plants (e.g. ARIES-RS [Fusion Eng. Des. 38 (1997) 3; Fusion Eng. Des. 38 (1997) 87]) such that exotic technologies were not required in order to satisfy all of the design criteria. Najmabadi and the ARIES Team [Fusion Eng. Des. (this issue)] provide an overview of ARIES-ST design. In this article, the details of the power core design are presented together with analysis of the thermal-hydraulic, thermomechanical and materials behavior of in-vessel components. Detailed engineering analysis of ARIES-ST TF and PF systems, nuclear analysis, and safety are given in the companion papers

Comparative Prevalence of Immune Evasion Complex Genes Associated with β-Hemolysin Converting Bacteriophages in MRSA ST5 Isolates from Swine, Swine Facilities, Humans with Swine Contact, and Humans with No Swine Contact.

Directory of Open Access Journals (Sweden)

Samantha J Hau

Full Text Available Livestock associated methicillin-resistant Staphylococcus aureus (LA-MRSA draws concern from the public health community because in some countries these organisms may represent the largest reservoir of MRSA outside hospital settings. Recent studies indicate LA-MRSA strains from swine are more genetically diverse than the first reported sequence type ST398. In the US, a diverse population of LA-MRSA is found including organisms of the ST398, ST9, and ST5 lineages. Occurrence of ST5 MRSA in swine is of particular concern since ST5 is among the most prevalent lineages causing clinical infections in humans. The prominence of ST5 in clinical disease is believed to result from acquisition of bacteriophages containing virulence or host-adapted genes including the immune-evasion cluster (IEC genes carried by β-hemolysin converting bacteriophages, whose absence in LA-MRSA ST398 is thought to contribute to reduced rates of human infection and transmission associated with this lineage. The goal of this study was to investigate the prevalence of IEC genes associated with β-hemolysin converting bacteriophages in MRSA ST5 isolates obtained from agricultural sources, including swine, swine facilities, and humans with short- or long-term swine exposure. To gain a broader perspective, the prevalence of these genes in LA-MRSA ST5 strains was compared to the prevalence in clinical MRSA ST5 strains from humans with no known exposure to swine. IEC genes were not present in any of the tested MRSA ST5 strains from agricultural sources and the β-hemolysin gene was intact in these strains, indicating the bacteriophage's absence. In contrast, the prevalence of the β-hemolysin converting bacteriophage in MRSA ST5 strains from humans with no exposure to swine was 90.4%. The absence of β-hemolysin converting bacteriophage in LA-MRSA ST5 isolates is consistent with previous reports evaluating ST398 strains and provides genetic evidence indicating LA-MRSA ST5 isolates

Comparative Prevalence of Immune Evasion Complex Genes Associated with β-Hemolysin Converting Bacteriophages in MRSA ST5 Isolates from Swine, Swine Facilities, Humans with Swine Contact, and Humans with No Swine Contact

Science.gov (United States)

Hau, Samantha J.; Sun, Jisun; Davies, Peter R.; Frana, Timothy S.; Nicholson, Tracy L.

2015-01-01

Livestock associated methicillin-resistant Staphylococcus aureus (LA-MRSA) draws concern from the public health community because in some countries these organisms may represent the largest reservoir of MRSA outside hospital settings. Recent studies indicate LA-MRSA strains from swine are more genetically diverse than the first reported sequence type ST398. In the US, a diverse population of LA-MRSA is found including organisms of the ST398, ST9, and ST5 lineages. Occurrence of ST5 MRSA in swine is of particular concern since ST5 is among the most prevalent lineages causing clinical infections in humans. The prominence of ST5 in clinical disease is believed to result from acquisition of bacteriophages containing virulence or host-adapted genes including the immune-evasion cluster (IEC) genes carried by β-hemolysin converting bacteriophages, whose absence in LA-MRSA ST398 is thought to contribute to reduced rates of human infection and transmission associated with this lineage. The goal of this study was to investigate the prevalence of IEC genes associated with β-hemolysin converting bacteriophages in MRSA ST5 isolates obtained from agricultural sources, including swine, swine facilities, and humans with short- or long-term swine exposure. To gain a broader perspective, the prevalence of these genes in LA-MRSA ST5 strains was compared to the prevalence in clinical MRSA ST5 strains from humans with no known exposure to swine. IEC genes were not present in any of the tested MRSA ST5 strains from agricultural sources and the β-hemolysin gene was intact in these strains, indicating the bacteriophage’s absence. In contrast, the prevalence of the β-hemolysin converting bacteriophage in MRSA ST5 strains from humans with no exposure to swine was 90.4%. The absence of β-hemolysin converting bacteriophage in LA-MRSA ST5 isolates is consistent with previous reports evaluating ST398 strains and provides genetic evidence indicating LA-MRSA ST5 isolates may harbor a

CDC WONDER: Population - Bridged-Race July 1st Estimates

Data.gov (United States)

U.S. Department of Health & Human Services — The Population - Bridged-Race July 1st Estimates online databases report bridged-race population estimates of the July 1st resident population of the United States,...

Perinnöstä luopuminen

OpenAIRE

Skoutti, Miia

2013-01-01

Tämän opinnäytetyön keskeisenä aiheena oli tutkia perinnöstä luopumiseen liittyviä edellytyksiä ja seurauksia. Tarkoituksena oli käsitellä perinnöstä luopumista erilaisista näkökulmista sekä miettiä joitakin siihen johtavia syitä. Opinnäytetyöhön sisältyy olennaisesti myös yleisesti perintöoikeudellisten asioiden selvittäminen. Opinnäytetyön alussa lukijalle selitetään lyhyesti sitä, mitä on lakimääräinen perimysjärjestys, ja miten perintöä voi Suomessa saada. Lisäksi huomiota kiinnitetään lu...

Omsorg/støtte i ungdomsskolen

OpenAIRE

Vasseng, Eli Dahl

2012-01-01

Master's thesis in Special education Denne studien handler om forholdet mellom lærer-elev og ser på hvordan ungdomsskoleelever beskriver omsorgsfulle/støttende lærere og den betydning det har for motivasjon i skolearbeid og læringsmiljø. Jeg har tatt utgangspunkt i ungdomsskoleelevenes forståelse av fenomenet omsorg/støtte og brukt en fenomenologisk tilnærming med intervju som metode. Seks elever fra ungdomstrinnet ble intervjuet og jeg har brukt en intervjuguide som er bygget på det teore...

Statistics in the 21st century

CERN Document Server

Wells, Martin T; Wells, Martin T

2001-01-01

Exactly what is the state of the art in statistics as we move forward into the 21st century? What promises, what trends does its future hold? Through the reflections of 70 of the world's leading statistical methodologists, researchers, theorists, and practitioners, Statistics in the 21st Century answers those questions. Originally published in the Journal of the American Statistical Association, this collection of vignettes examines our statistical past, comments on our present, and speculates on our future. Although the coverage is broad and the topics diverse, it reveals the essential intell

Energirenovering af større bygninger

DEFF Research Database (Denmark)

Mortensen, Lone Hedegaard; Birck Laustsen, Jacob; Vorre, Mette Havgaard

involverede parter i et renoveringsprojekt om, hvordan energirenoveringsprojekter gennemføres i alle faser. SBi-anvisning 269 kan bruges som styringsredskab for bygherrer og kravgrundlag for rådgivere, entreprenører og andre parter, der leverer ydelser til bygherren. For institutioner, der stiller kapital til......​SBi-anvisning 269 omhandler metode og proces for gennemførelse af energirenoveringsprojekter for større bygninger fra idefase til driftsfase. Større bygninger omfatter etageboliger, bygninger til privat handel- og service samt offentlige institutioner. Anvisningen giver vejledning for de...

Energy in ASEAN: An outlook into the 21st century

Science.gov (United States)

Arismunandar, A.; Dupuis, P.

The Association of Southeast Asian Nations (ASEAN) was formed in Bangkok in 1967 by five countries: Indonesia, Malaysia, the Philippines, Singapore, and Thailand. A sixth nation, recently independent Brunei Darussalam, joined the association in 1984. The story on enery in the ASEAN is presented. The topics covered include the following: energy resources; energy demand versus elasticity; how to cope with energy demand; and an outlook into the 21st century.

Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes?

Directory of Open Access Journals (Sweden)

Ashley M Miller

Full Text Available Preliminary data mostly from animal models suggest the sST2/IL-33 pathway may have causal relevance for vascular disease and diabetes and thus point to a potential novel inflammatory link to cardiometabolic disease. However, the characterisation of sST2 levels in terms of metabolic or vascular risk in man is completely lacking. We sought to address this gap via a comprehensive analysis of risk factor and vascular correlates of sST2 in a cross-sectional study (pSoBid. We measured sST2 in plasma in 639 subjects and comprehensively related it to cardiovascular and diabetes risk factors and imaged atherosclerosis measures. Circulating sST2 levels increased with age, were lower in women and in highest earners. After adjusting for age and gender, sST2 levels associated strongly with markers of diabetes, including triglycerides [effect estimate (EE per 1 standard deviation increase in sST2:1.05 [95%CI 1.01,1.10], liver function (alanine aminotransaminase [ALT] and γ-glutamyl transferase [GGT]: EE 1.05 [1.01,1.09] and 1.13 [1.07,1.19] respectively, glucose (1.02 [1.00,1.03] and sICAM-1 (1.05 [1.02,1.07]. However, sST2 levels were not related to smoking, cholesterol, blood pressure, or atheroma (carotid intima media thickness, plaque presence. These results suggest that sST2 levels, in individuals largely without vascular disease, are related principally to markers associated with diabetes and ectopic fat and add support for a role of sST2 in diabetes. Further mechanistic studies determining how sST2 is linked to diabetes pathways may offer new insights into the inflammatory paradigm for type 2 diabetes.

Anatomical relationship between traditional acupuncture point ST 36 and Omura's ST 36 (True ST 36) with their therapeutic effects: 1) inhibition of cancer cell division by markedly lowering cancer cell telomere while increasing normal cell telomere, 2) improving circulatory disturbances, with reduction of abnormal increase in high triglyceride, L-homocystein, CRP, or cardiac troponin I & T in blood by the stimulation of Omura's ST 36--Part 1.

Science.gov (United States)

Omura, Yoshiaki; Chen, Yemeng; Lu, Dominic P; Shimotsura, Yasuhiro; Ohki, Motomu; Duvvi, Harsha

2007-01-01

Using Bi-Digital O-Ring Test Resonance Phenomena between 2 identical substances, Omura, Y. succeeded in making the image of the outline of internal organs without use of standard imaging devices since 1982. When he imaged the outline of the stomach on the abdominal wall, a number of the lines came out from upper and lower parts of stomach wall. When the lines were followed, they were very close to the well-known stomach meridians. Subsequently, he found a method of localizing meridians and their corresponding acupuncture points as well as shapes and diameters accurately. At the anatomical location of ST 36 described in traditional textbooks, Omura, Y. found there is no acupuncture point. However, in the close vicinity, there is an acupuncture point which he named as true ST 36 in the mid 1980s, but it is generally known as Omura's ST 36. When the effects of the acupuncture on these 2 locations were compared, Omura's ST 36 (true ST 36) produced very significant well-known acupuncture beneficial effects including improved circulation and blood chemistry, while in the traditional ST 36, the effects were small. In this article, the anatomical relationship between these two acupuncture points, with a short distance of 0.6 approximately 1.5 cm between the centers of these locations, was described. In early 2000, Omura, Y. found Press Needle Stimulation of Omura's ST 36, using "Press-Release" procedure repeated 200 times, 4 times a day to cancer patients reduced high cancer cell telomere of 600-1500ng and high Oncogen C-fos Ab2 and Integrin alpha5beta1 of 100-700ng BDORT units to close to lyg (= 10(-24) g) BDORT units. In addition there was a significant reduction of Asbestos and Hg from cancer cells, while markedly reduced normal cell telomere of lyg was increased to optimally high amounts of 500-530ng BDORTunits. Thus, cancer cells can no longer divide and cancer activity is inhibited. The authors have successfully applied this method for a variety of cancers as well as

Polymorphisms of ST2-IL18R1-IL18RAP gene cluster: a new risk for autoimmune thyroid diseases.

Science.gov (United States)

Wang, X; Zhu, Y F; Li, D M; Qin, Q; Wang, Q; Muhali, F S; Jiang, W J; Zhang, J A

2016-02-01

Interleukin 33 (IL33) / ST2 pathway and ST2-interlukin18 receptor1-interlukin18 receptor accessory protein (ST2-IL18R1-IL18RAP) gene cluster have been involved in many autoimmune diseases but few report in autoimmune thyroid diseases (AITD). In this study, we investigated whether polymorphisms of IL33, ST2, IL18R1, and IL18RAP are associated with Graves' disease (GD) and Hashimoto's thyroiditis (HT), two major forms of AITD, among a Chinese population. A total of 11 SNPs were explored in a case-control study including 417 patients with GD, 250 HT patients and 301 controls, including rs1929992, rs10975519, rs10208293, rs6543116, rs1041973, rs3732127, rs11465597, rs1035130, rs2293225, rs1035127, rs917997 of IL 33, ST2-IL18R1-IL18RAP gene cluster. Genotyping of these SNPs was performed using matrix-assisted laser desorption / ionization-time-of-flight mass spectrometer (MALDI-TOF-MS) platform from Sequenom. The frequencies of allele A and AA+AG genotype of rs6543116 (ST2) in HT patients were significantly increased compared with those of the controls (P = 0.029/0.021, OR = 1.31/1.62). And in another SNP rs917997, AA+AG genotype presented an increased frequency in HT subjects compared with controls (P = 0.046, OR = 1.53). Furthermore, the haplotype GAGCCCG from ST2-IL18R1-IL18RAP gene cluster (rs6543116, rs1041973, rs1035130, rs3732127, rs1035127, rs2293225, rs917997) was associated with increased susceptibility to GD with an OR of 2.03 (P = 0.022, 95% CI = 1.07-3.86). Some SNPs of ST2-IL18R1-IL18RAP gene cluster might increase the risk of susceptibility of HT and GD in Chinese Han population. © 2015 John Wiley & Sons Ltd.

Is the CERN recommended SCADA useable for the ST division?

CERN Document Server

Sollander, P; Epting, U

2001-01-01

Supervisory Control and Data Acquisition (SCADA) systems are widely used at CERN and in industrial control environments. In order to limit the costs of purchase, maintenance and support, a recommendation for one SCADA system is in preparation by the SCADA working group. This SCADA system should be used for all CERN in-house developed applications as they exist today e.g. in the Technical Control Room (TCR). This presentation will show the actual environment for the control and monitoring of the technical infrastructure at CERN and the needs for the future LHC infrastructure monitoring. The presentation will cover the control activities of all ST groups represented in the ST Control System WG. A possible solution for the integration of the technical infrastructure data into a SCADA system and a solution for the data exchange with the accelerators and the experiments will be presented. This includes a short term planning for the evaluation period as well as the long-term strategy on how to implement the chosen ...

The mean, the median, and the St. Petersburg paradox.

Science.gov (United States)

Hayden, Benjamin Y; Platt, Michael L

2009-06-01

The St. Petersburg Paradox is a famous economic and philosophical puzzle that has generated numerous conflicting explanations. To shed empirical light on this phenomenon, we examined subjects' bids for one St. Petersburg gamble with a real monetary payment. We found that bids were typically lower than twice the smallest payoff, and thus much lower than is generally supposed. We also examined bids offered for several hypothetical variants of the St. Petersburg Paradox. We found that bids were weakly affected by truncating the gamble, were strongly affected by repeats of the gamble, and depended linearly on the initial "seed" value of the gamble. One explanation, which we call the median heuristic , strongly predicts these data. Subjects following this strategy evaluate a gamble as if they were taking the median rather than the mean of the payoff distribution. Finally, we argue that the distribution of outcomes embodied in the St. Petersburg paradox is so divergent from the Gaussian form that the statistical mean is a poor estimator of expected value, so that the expected value of the St. Petersburg gamble is undefined. These results suggest that this classic paradox has a straightforward explanation rooted in the use of a statistical heuristic.

Geology of St. John, U.S. Virgin Islands

Science.gov (United States)

Rankin, Douglas W.

2002-01-01

The rocks of St. John, which is located near the eastern end of the Greater Antilles and near the northeastern corner of the Caribbean plate, consist of Cretaceous basalt, andesite, keratophyre, their volcaniclastic and hypabyssal intrusive equivalents, and minor calcareous rocks and chert. These rocks were intruded by Tertiary mafic dikes and tonalitic plutons. The oldest rocks formed in an extensional oceanic environment characterized by abundant keratophyre and sheeted dikes. Subduction-related volcanism of the east-west-trending marine Greater Antilles volcanic arc began on St. John near the transition between the Early and Late Cretaceous. South-directed compression, probably caused by the initial collision between the Greater Antilles arc of the Caribbean plate and the Bahama platform of the North American plate, deformed the Cretaceous strata into east-west-trending folds with axial-plane cleavage. Late Eocene tonalitic intrusions, part of the Greater Antilles arc magmatism, produced a contact aureole that is as much as two kilometers wide and that partly annealed the axial-plane cleavage. East-west compression, possibly related to the relative eastward transport of the Caribbean plate in response to the beginning of spreading at the Cayman Trough, produced long-wavelength, low-amplitude folds whose axes plunge gently north and warp the earlier folds. A broad north-plunging syncline-anticline pair occupies most of St. John. The last tectonic event affecting St. John is recorded by a series of post-late Eocene sinistral strike-slip faults related to the early stages of spreading at the Cayman Trough spreading center and sinistral strike-slip accommodation near the northern border of the Caribbean plate. Central St. John is occupied by a rhomb horst bounded by two of these sinistral faults. Unlike other parts of the Greater Antilles, evidence for recent tectonic movement has not been observed on St. John.

Childhood victimization experiences of young adults in St. Petersburg, Russia.

Science.gov (United States)

Bogolyubova, Olga; Skochilov, Roman; Smykalo, Lyubov

2015-04-01

The purpose of this study was to assess the prevalence of childhood victimization experiences in a sample of young adults in St. Petersburg, Russia. The study sample included 743 students aged 19 to 25 from 15 universities in St. Petersburg, Russia. All of the study participants completed a reliable questionnaire assessing the following types of childhood victimization: conventional crime, child maltreatment, peer victimization, sexual victimization, and witnessing violence. Participation in the study was anonymous. High rates of victimization and exposure to violence were reported by the study participants. The majority of the sample experienced at least one type of victimization during childhood or adolescence, and poly-victimization was reported frequently. The most common type of victimization reported was peer or sibling assault (66.94%), followed by witnessing an assault without weapon (63.91%), personal theft (56.19%), vandalism (56.06%), and emotional bullying (49.99%). Sexual assault by a known adult was reported by 1.45% males and 5.16% of females. This study provides new information on the scope of childhood victimization experiences in Russia. Further research is warranted, including epidemiological research with representative data across the country and studies of the impact of trauma and victimization on mental health and well-being of Russian adults and children. © The Author(s) 2014.

Alternative Fuels Data Center: St. Louis Airport Relies on Biodiesel and

Science.gov (United States)

Natural Gas Vehicles St. Louis Airport Relies on Biodiesel and Natural Gas Vehicles to someone by E-mail Share Alternative Fuels Data Center: St. Louis Airport Relies on Biodiesel and Natural Gas Vehicles on Facebook Tweet about Alternative Fuels Data Center: St. Louis Airport Relies on Biodiesel and

Bovine-associated MRSA ST398 in The Netherlands

Directory of Open Access Journals (Sweden)

Tavakol Mehri

2012-05-01

Full Text Available Abstract During routinely screening (50.000 milk samples on an annual basis 14 MRSA ST398 strains were identified in the period of January 2008 to September 2008 in 14 different dairy herds located in the provinces Overijssel and Gelderland, The Netherlands. Molecular analysis was performed by Cfr9I PFGE, ST398-specific diagnostic PCR, spa typing, SCCmec typing and Panton-Valentine Leukocidin (PVL gene PCR. The molecular analyses of 14 MRSA (one MRSA strain per herd strains revealed that all strains belong to ST398 with 3 closely related spa types (t011, t108 and t889, all commonly found in pigs and carry 2 different SCCmec types, IVa and V. All MRSA strains were resistant to two or more classes of antibiotics and also PVL negative. The majority of farms (n = 9, 64% harboured combined livestock with both cows and pigs present. Our study contributes to the growing evidence that MRSA ST398 is transmitted among various animal species and can be considered as an etiological agent of mastitis in dairy cows.

Methylphenidatinduceret ST-elevations-myokardieinfarkt

DEFF Research Database (Denmark)

Ruwald, Martin Huth; Ruwald, Anne-Christine Huth; Tønder, Niels

2012-01-01

Adult attention deficit and hyperkinetic disorder (ADHD) is increasingly diagnosed and treated with methylphenidate. We present the case of an 20 year-old man, who was diagnosed with ADHD and suffered a ST elevation acute myocardial infarction due to coronary vasospasm related to an overdose...

Simple stålrammebygninger

DEFF Research Database (Denmark)

Ellum, J.C.

Anvisningen gennemgår dimensioneringen og bringer detaljerede konstruktionstegninger til simple stålrammebygninger, dvs. lukkede, fritliggende bygninger i én etage, hvor tagkonstruktionen ud over egenlast kun er påvirket af naturlaster, dvs. sne og vind. Dimensioneringen sker ved at udfylde et di...

Right bundle branch block and anterior wall ST elevation myocardial infarction.

Science.gov (United States)

Trofin, Monica; Israel, Carsten W; Barold, S Serge

2017-09-01

We report the case of an acute anterior wall ST elevation myocardial infarction with new left anterior fascicular block and pre-existing right bundle branch block. Due to a wide right bundle branch block, no ST segment elevation was visible in lead V1. The left anterior fascicular block was caused by proximal occlusion of the left artery descending and disappeared after acute revascularization. However, also the R' of the right bundle branch block became significantly shorter after revascularization, dismanteling a minor ST segment elevation. The ST elevation in lead V1 in anterior wall infarction and right bundle branch block may merge with the R' and cause a further QRS widening as an "equivalent" to the ST elevation.

MHD simulation of relaxation to a flipped ST configuration

Energy Technology Data Exchange (ETDEWEB)

Kagei, Y [Department of Electrical Engineering and Computer Sciences, Himeji Institute of Technology, Himeji, Hyogo (Japan); Nagata, M [Department of Electrical Engineering and Computer Sciences, Himeji Institute of Technology, Himeji, Hyogo (Japan); Suzuki, Y [Center for Promotion of Computational Science and Engineering, Japan Atomic Energy Research Institute, Taito-ku, Tokyo (Japan); Kishimoto, Y [Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka-machi, Ibaraki (Japan); Hayashi, T [National Institute for Fusion Science, Toki, Gifu (Japan); Uyama, T [Department of Electrical Engineering and Computer Sciences, Himeji Institute of Technology, Himeji, Hyogo (Japan)

2003-02-01

The dynamics of spherical torus (ST) plasmas, when the external toroidal magnetic field is decreased to zero and then increased in the opposite direction, has been investigated using three-dimensional magnetohydrodynamic (MHD) numerical simulations. It has been found that the flipped ST configuration is self-organized after the ST configuration collapses because of the growth of the n = 1 mode in the open flux region and a following magnetic reconnection event. During the transition between these configurations, not only the paramagnetic toroidal field but also the poloidal field reverses polarity spontaneously. (letter to the editor)

Bathymetry (2011) of the St. Thomas East End Reserve

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 0.3x0.3 meter resolution depth surface for the St. Thomas East End Reserve (STEER), St. Thomas in the...

Survival in patients without acute ST elevation after cardiac arrest and association with early coronary angiography

DEFF Research Database (Denmark)

Dankiewicz, J; Nielsen, N; Annborn, M

2015-01-01

PURPOSE: To investigate whether early coronary angiography (CAG) after out-of-hospital cardiac arrest of a presumed cardiac cause is associated with improved outcomes in patients without acute ST elevation. METHODS: The target temperature management after out-of-hospital cardiac arrest (TTM) trial...... showed no difference in all-cause mortality or neurological outcome between an intervention of 33 and 36 °C. In this post hoc analysis, 544 patients where the admission electrocardiogram did not show acute ST elevation were included. Early CAG was defined as being performed on admission or within...... early CAG was not significantly associated with survival. CONCLUSIONS: In this post hoc observational study of a large randomized trial, early coronary angiography for patients without acute ST elevation after out-of-hospital cardiac arrest of a presumed cardiac cause was not associated with improved...

Policy perspective on the global use of Smokeless Tobacco (ST: a literature review

Directory of Open Access Journals (Sweden)

Kamran Siddiqi

2018-03-01

gaps in the implementation of key demand-reduction measures with regard to ST. Methods A series of focused literature reviews was conducted and findings were synthesized by relevant Articles (6 - 14 of the World Health Organization Framework Convention on Tobacco Control (WHO FCTC. Results We found sufficient evidence to support implementation of key demand-reduction measures for ST. For example, raising taxes can reduce ST consumption, with price elasticity on a par with, or sometimes higher than, cigarettes. Similarly, graphic pictorial warnings on ST packaging are far more effective than text-only warning labels. But despite supportive evidence, countries have either not implemented measures or have kept the bar much lower than that for cigarettes. For example, very few countries regulate the contents of ST products. Some have raised ST taxes but not to the extent of cigarette taxes, risking product substitution. Similarly, health-warning requirements for ST are less strict than those for cigarettes. Even where strong policies exist, compliance has been poor. For example, despite bans on ST advertising, most suppliers continue to promote products, especially at points of sale and via print and digital media. Consequently, ST demand-reduction measures have had limited impact. Conclusions The full implementation of FCTC Articles 6-14 is likely to reduce the global demand for ST, but their current state of implementation lags behind that for cigarettes. The existing policy gaps can be addressed through better knowledge of ST products, setting unambiguous standards, innovative systems for tax administration, building capacity in testing ST products and undertaking targeted research.

Methicillin-resistant Staphylococcus aureus in Rio de Janeiro hospitals: dissemination of the USA400/ST1 and USA800/ST5 SCCmec type IV and USA100/ST5 SCCmec type II lineages in a public institution and polyclonal presence in a private one.

Science.gov (United States)

Caboclo, Roberta Mello Ferreira; Cavalcante, Fernanda Sampaio; Iorio, Natalia Lopes Pontes; Schuenck, Ricardo Pinto; Olendzki, André Nogueira; Felix, Maria José; Chamon, Raiane Cardoso; dos Santos, Kátia Regina Netto

2013-03-01

Methicillin-resistant Staphylococcus aureus (MRSA) infections have changed since certain non-multiresistant MRSA lineages have emerged in hospitals. In this study, 99 MRSA isolates, 77 from a public and 22 from a private hospital, were characterized. Isolates were tested for antimicrobial susceptibility, whereas staphylococcal chromosomal cassette mec (SCCmec) typing and Panton-Valentine leukocidin genes were assessed by polymerase chain reaction. Pulsed-field gel electrophoresis and multilocus sequence typing analyses were carried out to determine the MRSA lineages. High rates of resistance were found to erythromycin (96%), ciprofloxacin (93%), and clindamycin (90%). The SCCmec types found were as follows: type II (14.2%), III (62.6%), and IV (23.2%). Approximately 85% of type III isolates was related to the Brazilian epidemic clone in both hospitals. For type IV isolates, 94.4% were related to both USA400/ sequence type (ST) 1 and USA800/ST5 lineages in the public hospital, whereas the USA400/ST1, USA800/ST5, USA1100/ST30, and EMRSA (Epidemic MRSA)-15/ST22 lineages were detected in the private hospital. Among the SCCmec II isolates, approximately 85% were related to the USA100/ST5 lineage. Three MRSA isolates were positive to Panton-Valentine leukocidin genes. The study showed that there was an emergence of USA400/ST1, USA800/ST5 SCCmec IV, and USA100/ST5 SCCmec II MRSA lineages in both hospitals. There was a dissemination of them in the public hospital and a polyclonal presence of the MRSA isolates in the private hospital. The spread of these lineages can be facilitated by the characteristics of the health institution. Copyright © 2013 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.

Doppler derived gradient of ST Jude Mechanical Prosthesis, early postoperative assessment

International Nuclear Information System (INIS)

Shaikh, A.H.; Hanif, B.; Adil, A.; Hashimi, S.; Qazi, H.A.; Mujtaba, I.

2010-01-01

Objective: To determine the doppler derived mean gradients of St Jude mechanical prosthesis in early postoperative period in patients undergoing valve replacement at a tertiary care cardiac centre. Methods: Medical records of 190 consecutive patients who underwent 233 mitral, aortic or dual (mitral and aortic) valve replacement by St Jude bileaflet mechanical prosthesis at Tabba Heart Institute, between March 2006 to December 2008 were reviewed. Doppler derived mean gradients were assessed predischarge and recorded. Results: There were 98 (51.5%) males and 92 (48.5%) females in the study cohort. The mean age was 40 +- 14 years. Of the total, 101 (53%) had mitral, 46 (24.2%) had aortic and 43 (22.6%) patients had dual valve replacement. Doppler derived mean gradient was assessed across 144 mitral and 89 aortic St Jude mechanical prosthesis. Doppler derived mean gradient for St Jude mitral prosthesis was 3.5 mm Hg and for St Jude aortic prosthesis was 10.2 mm Hg. Conclusions: The study determines baseline gradients across mitral and aortic St Jude mechanical prosthesis in our population. These can be used as reference gradients to assess St Jude prosthetic valve function in patients who did not have early postoperative doppler assessment. (author)

Organ accumulation and subcellular location of Cicer arietinum ST1 protein.

Science.gov (United States)

Albornos, Lucía; Cabrera, Javier; Hernández-Nistal, Josefina; Martín, Ignacio; Labrador, Emilia; Dopico, Berta

2014-07-01

The ST (ShooT Specific) proteins are a new family of proteins characterized by a signal peptide, tandem repeats of 25/26 amino acids, and a domain of unknown function (DUF2775), whose presence is limited to a few families of dicotyledonous plants, mainly Fabaceae and Asteraceae. Their function remains unknown, although involvement in plant growth, fruit morphogenesis or in biotic and abiotic interactions have been suggested. This work is focused on ST1, a Cicer arietinum ST protein. We established the protein accumulation in different tissues and organs of chickpea seedlings and plants and its subcellular localization, which could indicate the possible function of ST1. The raising of specific antibodies against ST1 protein revealed that its accumulation in epicotyls and radicles was related to their elongation rate. Its pattern of tissue location in cotyledons during seed formation and early seed germination, as well as its localization in the perivascular fibres of epicotyls and radicles, indicated a possible involvement in seed germination and seedling growth. ST1 protein appears both inside the cell and in the cell wall. This double subcellular localization was found in every organ in which the ST1 protein was detected: seeds, cotyledons and seedling epicotyls and radicles. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Regulation of StAR by the N-terminal Domain and Coinduction of SIK1 and TIS11b/Znf36l1 in Single Cells.

Science.gov (United States)

Lee, Jinwoo; Tong, Tiegang; Duan, Haichuan; Foong, Yee Hoon; Musaitif, Ibrahim; Yamazaki, Takeshi; Jefcoate, Colin

2016-01-01

The cholesterol transfer function of steroidogenic acute regulatory protein (StAR) is uniquely integrated into adrenal cells, with mRNA translation and protein kinase A (PKA) phosphorylation occurring at the mitochondrial outer membrane (OMM). The StAR C-terminal cholesterol-binding domain (CBD) initiates mitochondrial intermembrane contacts to rapidly direct cholesterol to Cyp11a1 in the inner membrane (IMM). The conserved StAR N-terminal regulatory domain (NTD) includes a leader sequence targeting the CBD to OMM complexes that initiate cholesterol transfer. Here, we show how the NTD functions to enhance CBD activity delivers more efficiently from StAR mRNA in adrenal cells, and then how two factors hormonally restrain this process. NTD processing at two conserved sequence sites is selectively affected by StAR PKA phosphorylation. The CBD functions as a receptor to stimulate the OMM/IMM contacts that mediate transfer. The NTD controls the transit time that integrates extramitochondrial StAR effects on cholesterol homeostasis with other mitochondrial functions, including ATP generation, inter-organelle fusion, and the major permeability transition pore in partnership with other OMM proteins. PKA also rapidly induces two additional StAR modulators: salt-inducible kinase 1 (SIK1) and Znf36l1/Tis11b. Induced SIK1 attenuates the activity of CRTC2, a key mediator of StAR transcription and splicing, but only as cAMP levels decline. TIS11b inhibits translation and directs the endonuclease-mediated removal of the 3.5-kb StAR mRNA. Removal of either of these functions individually enhances cAMP-mediated induction of StAR. High-resolution fluorescence in situ hybridization (HR-FISH) of StAR RNA reveals asymmetric transcription at the gene locus and slow RNA splicing that delays mRNA formation, potentially to synchronize with cholesterol import. Adrenal cells may retain slow transcription to integrate with intermembrane NTD activation. HR-FISH resolves individual 3.5-kb St

Cooperative learning in 21st century

Directory of Open Access Journals (Sweden)

David W. Johnson

2014-10-01

Full Text Available The 21st century brings four important challenges in which cooperation plays a central role: (1 a rapidly increasing global interdependence that will result in increasing local diversity as well as more frequent and intense conflicts, (2 the increasing number of democracies throughout the world, (3 the need for creative entrepreneurs, and (4 the growing importance of interpersonal relationships that affect the development of personal identity. The tools for meeting these challenges include cooperative learning. In this article the nature of cooperative learning will be reviewed, the underlying theory of social interdependence will be discussed, and the results of the research on cooperative learning will be briefly reviewed. The way in which cooperative learning contributes to meeting the four challenges will then be discussed.

Communication from ST Group

CERN Multimedia

TS Department

2008-01-01

In order to prepare the organization of the Open Days, please note that FM Group will not able to take into account either specific requests for waste collection from 2nd to 6th of April, either removal or PC transport requests between the 31st and the 11th of March. We kindly ask you to plan the collection of any type of waste and the urgent transport of office furniture or PC before the 31st of March. Waste collection requests shall be formulated contacting FM Support at 77777 or at the email address mailto:Fm.Support@cern.ch; removal of office furniture or PC transport requests must be made using the EDH ‘Transport request’ form selecting the "Removals" or the "PC transport" category from the drop-down menu. For any question concerning the waste sorting, please consult the following web address: http://dechets-waste.web.cern.ch/dechets-waste/. Thank you for your understanding and collaboration. TS/FM Group

Neutron flux distribution measurement in the Fort St. Vrain initial core (results of Fort St. Vrain start-up test A-7)

International Nuclear Information System (INIS)

Marshall, A.C.; Brown, J.R.

1975-01-01

A description is given of a test to measure the axial flux distribution at several radial locations in the Fort St. Vrain core representing unrodded, rodded, and partially rodded regions. The measurements were intended to verify the calculational accuracy of the three-dimensional calculational model used to compute axial power distributions for the Fort St. Vrain core. (U.S.)

Soybean Salt Tolerance 1 (GmST1) Reduces ROS Production, Enhances ABA Sensitivity, and Abiotic Stress Tolerance in Arabidopsis thaliana.

Science.gov (United States)

Ren, Shuxin; Lyle, Chimera; Jiang, Guo-Liang; Penumala, Abhishek

2016-01-01

Abiotic stresses, including high soil salinity, significantly reduce crop production worldwide. Salt tolerance in plants is a complex trait and is regulated by multiple mechanisms. Understanding the mechanisms and dissecting the components on their regulatory pathways will provide new insights, leading to novel strategies for the improvement of salt tolerance in agricultural and economic crops of importance. Here we report that soybean salt tolerance 1, named GmST1, exhibited strong tolerance to salt stress in the Arabidopsis transgenic lines. The GmST1-overexpressed Arabidopsis also increased sensitivity to ABA and decreased production of reactive oxygen species under salt stress. In addition, GmST1 significantly improved drought tolerance in Arabidopsis transgenic lines. GmST1 belongs to a 3-prime part of Glyma.03g171600 gene in the current version of soybean genome sequence annotation. However, comparative reverse transcription-polymerase chain reaction analysis around Glyma.03g171600 genomic region confirmed that GmST1 might serve as an intact gene in soybean leaf tissues. Unlike Glyma.03g171600 which was not expressed in leaves, GmST1 was strongly induced by salt treatment in the leaf tissues. By promoter analysis, a TATA box was detected to be positioned close to GmST1 start codon and a putative ABRE and a DRE cis-acting elements were identified at about 1 kb upstream of GmST1 gene. The data also indicated that GmST1-transgenic lines survived under drought stress and showed a significantly lower water loss than non-transgenic lines. In summary, our results suggest that overexpression of GmST1 significantly improves Arabidopsis tolerance to both salt and drought stresses and the gene may be a potential candidate for genetic engineering of salt- and drought-tolerant crops.

Soybean salt tolerance 1 (GmST1 reduces ROS production, enhances ABA sensitivity and abiotic stress tolerance in Arabidopsis thaliana

Directory of Open Access Journals (Sweden)

Shuxin eRen

2016-04-01

Full Text Available Abiotic stresses, including high soil salinity, significantly reduce crop production worldwide. Salt tolerance in plants is a complex trait and is regulated by multiple mechanisms. Understanding the mechanisms and dissecting the components on their regulatory pathways will provide new insights, leading to novel strategies for the improvement of salt tolerance in agricultural and economic crops of importance. Here we report that soybean salt tolerance 1, named GmST1, exhibited strong tolerance to salt stress in the Arabidopsis transgenic lines. The GmST1-overexpressed Arabidopsis also increased sensitivity to ABA and decreased production of reactive oxygen species (ROS under salt stress. In addition, GmST1 significantly improved drought tolerance in Arabidopsis transgenic lines. GmST1 belongs to a 3-prime part of Glyma.03g171600 gene in the current version of soybean genome sequence annotation. However, comparative RT-PCR analysis around Glyma.03g171600 genomic region confirmed that GmST1 might serve as an intact gene in soybean leaf tissues. Unlike Glyma.03g171600 which was not expressed in leaves, GmST1 was strongly induced by salt treatment in the leaf tissues. By promoter analysis, a TATA box was detected to be positioned close to GmST1 start codon and a putative ABRE and a DRE cis-acting elements were identified at about 1kb upstream of GmST1 gene. The data also indicated that GmST1-transgenic lines survived under drought stress and showed a significantly lower water loss than non-transgenic lines. In summary, our results suggest that overexpression of GmST1 significantly improves Arabidopsis tolerance to both salt and drought stresses and the gene may be a potential candidate for genetic engineering of salt- and drought-tolerant crops.

How 21st century droughts affect food and environmental security

Science.gov (United States)

Kogan, Felix

The first 13th years of the 21st century has begun with a series of widespread, long and intensive droughts around the world. Extreme and severe-to-extreme intensity droughts covered 2-6% and 7-16% of the world land, respectively, affecting environment, economies and humans. These droughts reduced agricultural production, leading to food shortages, human health deterioration, poverty, regional disturbances, population migration and death. This presentation is a travelogue of the 21st century global and regional droughts during the warmest years of the past 100 years. These droughts were identified and monitored with the NOAA operational space technology, called Vegetation Health (VH), which has the longest period of observation and provide good data quality. The VH method was used for assessment of vegetation condition or health, including drought early detection and monitoring. The VH method is based on operational satellites data estimating both land surface greenness (NDVI) and thermal conditions. The 21st century droughts in the USA, Russia, Australia Argentina, Brazil, China, India and other principal grain producing countries were intensive, long, covered large areas and caused huge losses in agricultural production, which affected food and environmental security and led to food riots in some countries. This presentation investigate how droughts affect food and environmental security, if they can be detected earlier, how to monitor their area, intensity, duration and impacts and also their dynamics during the climate warming era with satellite-based vegetation health technology.

REPERFUSION THERAPY IN ACUTE CORONARY SYNDROME WITH ST SEGMENT ELEVATION

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A. L. Alyavi

2016-01-01

Full Text Available Aim. To compare effect of percutaneous balloon angioplasty (PCA and a systemic thrombolysis (STL on the central and intracardiac hemodynamics in patients with acute coronary syndrome (ACS with ST segment elevation.Material and methods. 80 patients with ACS with ST segment elevation were included in the study. Patients were split into 2 groups depending on reperfusion strategy. PCA was performed in 55 patients (first group. 25 patients of the second group had STL with Streptokinase, i/v, 1 500 000 units per hour. Echocardiography was performed in all patients at admission and after 3 and 7 days of treatment to evaluate intracardiac hemodynamics.Results. Both reperfusion methods significantly increase of ejection fraction (EF and maximal output speed of left ventricle (LV. Increase of LV EF in patients after PCA was higher than this in patients after STL. PCA improved LV diastolic function; STL did not change this characteristic. After PCA working diagnosis of ACS was transformed to the following final diagnosis: acute myocardial infarction (AMI with Q, AMI without Q and unstable angina in 37,5, 30,4 and 32,1% of patients, respectively. After STL diagnosis of AMI with Q was defined in all patients.Conclusion. PCA in patients with ACS with ST segment elevation results in fast improvement of global systolic and diastolic LV function. Besides, PCA prevents AMI with Q in a half of these patients.

Control Strategy Tool (CoST)

Data.gov (United States)

U.S. Environmental Protection Agency — The EPA Control Strategy Tool (CoST) is a software tool for projecting potential future control scenarios, their effects on emissions and estimated costs. This tool...

Genomic Epidemiology of Hypervirulent Serogroup W, ST-11 Neisseria meningitidis.

Science.gov (United States)

Mustapha, Mustapha M; Marsh, Jane W; Krauland, Mary G; Fernandez, Jorge O; de Lemos, Ana Paula S; Dunning Hotopp, Julie C; Wang, Xin; Mayer, Leonard W; Lawrence, Jeffrey G; Hiller, N Luisa; Harrison, Lee H

2015-10-01

Neisseria meningitidis is a leading bacterial cause of sepsis and meningitis globally with dynamic strain distribution over time. Beginning with an epidemic among Hajj pilgrims in 2000, serogroup W (W) sequence type (ST) 11 emerged as a leading cause of epidemic meningitis in the African 'meningitis belt' and endemic cases in South America, Europe, Middle East and China. Previous genotyping studies were unable to reliably discriminate sporadic W ST-11 strains in circulation since 1970 from the Hajj outbreak strain (Hajj clone). It is also unclear what proportion of more recent W ST-11 disease clusters are caused by direct descendants of the Hajj clone. Whole genome sequences of 270 meningococcal strains isolated from patients with invasive meningococcal disease globally from 1970 to 2013 were compared using whole genome phylogenetic and major antigen-encoding gene sequence analyses. We found that all W ST-11 strains were descendants of an ancestral strain that had undergone unique capsular switching events. The Hajj clone and its descendants were distinct from other W ST-11 strains in that they shared a common antigen gene profile and had undergone recombination involving virulence genes encoding factor H binding protein, nitric oxide reductase, and nitrite reductase. These data demonstrate that recent acquisition of a distinct antigen-encoding gene profile and variations in meningococcal virulence genes was associated with the emergence of the Hajj clone. Importantly, W ST-11 strains unrelated to the Hajj outbreak contribute a significant proportion of W ST-11 cases globally. This study helps illuminate genomic factors associated with meningococcal strain emergence and evolution.

The Changing Pattern of Population Structure of Staphylococcus aureus from Bacteremia in China from 2013 to 2016: ST239-030-MRSA Replaced by ST59-t437.

Science.gov (United States)

Li, Shuguang; Sun, Shijun; Yang, Chentao; Chen, Hongbin; Yin, Yuyao; Li, Henan; Zhao, Chunjiang; Wang, Hui

2018-01-01

To investigate the epidemiology and genetic structure of Staphylococcus aureus bacteremia in China, a total of 416 isolates from 22 teaching hospitals in 12 cities from 2013 and 2016 were characterized by antibiogram analysis, multilocus sequence typing (MLST), spa typing and staphylococcal cassette chromosome mec (SCC mec ) typing. The predominant meticillin-susceptible (MSSA) genotypes in 2013 were ST188 (19.1%), ST7 (8.7%), and ST398 (7.8%), respectively, and they continued to be the main genotypes in 2016. The prevalence of meticillin-resistant S. aureus (MRSA) were 36.5% (66/181) and 36.6% (86/235) in 2013 and 2016, respectively. Interestingly, the susceptibility rates of MRSA to rifampicin and fluoroquinolones increased significantly from 2013 to 2016 ( P competition and fitness measurements were performed. Importantly, ST239-t030-MRSA displayed lower growth rate and lower competitive advantage compared to ST59-t437-MRSA. Together, our findings reveal that fitness advantage of ST59-t437-MRSA over ST239-t030-MRSA may lead to changes in genetic structure and increased susceptibility of MRSA to rifampicin and fluoroquinolones in Chinese patients with S. aureus bacteremia. Our study supports temporal dynamics in MRSA clone diversities, further providing critical insights into the importance of continued monitoring of MRSA.

Analysis and evaluation of recent operational experience from the Fort St. Vrain HTGR

International Nuclear Information System (INIS)

Moses, D.L.; Lanning, W.D.

1985-05-01

The Fort St. Vrain operating experience to be discussed here includes notable safety-related events which have occurred since late 1981 when ORNL was first contracted to provide technical assistance to AEOD. Earlier Fort St. Vrain operating experience through the time of successful full-power testing in November 1981 has been summarized by the licensee and the reactor vendor, GA Technologies, Inc. (GA), in papers presented at several different forums during 1982. In addition, extensive and very useful detailed evaluations of preoperational and startup testing and of the rise-to-power operating experience through completion of the first refueling outage in August 1979 have been compiled into a series of reports under the sponsorship of the Electric Power Research Institute (EPRI). Finally, the US Department of Energy's Fort St. Vrain Improvement Plan provides a summary of the major operational limits which have affected the plant since start-up. The events discussed here are categorized based on the major systems affected, namely, (1) primary system and reactor vessel, (2) electrical systems, and (3) the reactor building. In all cases to be discussed, the lessons to be learned are vigilance and prevention. These lessons translate into the need for the recognition and control of unexpected situations and of their potential for branching effects. At Fort St. Vrain, these lessons are found in the effects of moisture ingress, in the challenges experienced to the supply of essential electrical power, and in controlling the environment of the reactor building. 13 refs

Exercise induced ST elevation and residual myocardial ischemia in previous myocardial infarction

International Nuclear Information System (INIS)

Shimonagata, Tsuyoshi; Nishimura, Tsunehiko; Uehara, Toshiisa; Hayashida, Kohei; Saito, Muneyasu; Sumiyoshi, Tetsuya

1987-01-01

The purpose of this study was to evaluate the clinical significance of stress induced ST elevation on infarcted area in 65 patients with previous myocardial infarction (single vessel disease) who had stress thallium scan. Stress induced ST changes on infarcted area were compared with quantitative assessment of myocardial ischemia (thallium ischemic score; TIS) and extent of myocardial infarction (defect score; DS) derived from circumferential profile analysis. In patients with previous myocardial infarction in less than 3 month from the onset (n = 36), left ventricular ejection fraction (LVEF) and extent of abnormal LV wall motion were not significantly different between patients with stress induced ST elevation ( ≥ 2 mm, n = 26) and those with stress induced ST elevation ( < 2 mm, n = 10), while, in patients with previous myocardial infarction in more than 3 month (n = 29), patients with stress induced ST elevation ( ≥ 2 mm, n = 15) showed left ventricular dyskinesis more frequently than those with ST elevation ( < 2 mm, n = 14). In addition, the former showed significantly higher DS and significantly lower TIS than the latter. In patients with previous myocardial infarction in less than 3 month, patients with ST elevation ( ≥ 2 mm, n = 15) with prominent upright T wave (n = 15) had transient thallium defect in infarcted area in 73 % and they had significantly higher LVEF and TIS than those with ST elevation ( < 2 mm, n = 11). These results indicated that ST elevation in infarcted area reflect different significance according to the recovery of injured myocardium and stress induced ST elevation with prominent upright T wave in infarcted area reflect residual myocardial ischemia in less than 3 month from the onset of myocardial infarction. (author)

The First Outbreak Caused by Acinetobacter baumannii ST208 and ST195 in China

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Junyan Qu

2016-01-01

Full Text Available This study aimed to analyze the clinical characteristics of patients and molecular mechanisms of the first outbreak mainly caused by sequence types (STs 208 multidrug resistant (MDR Acinetobacter baumannii in China. A total of 10 clinical samples were collected from 5 patients who were involved in the outbreak. Bacterial identification and antibiotic sensitivity tests were performed by the VITEK-2 COMPACT automated system. MICs of tigecycline for clinical isolates were determined using broth microdilution. The clonal relatedness of A. baumannii clinical isolates in our local settings was determinated by pulsed-field gel electrophoresis (PFGE and multilocus sequence typing (MLST. A total of 7 A. baumannii strains were isolated and all were MDR strains; two of them were carbapenem-nonsusceptible strains. blaOXA-23 was the only acquired carbapenemase gene in the isolates. The isolates belonged to a single clonal pulsotype determined by PFGE and two sequences types (STs determined by MLST. The isolates belonged to the globally disseminated clonal complex 92, among which ST195 and ST208 were the most common sequence types (71.43% and 28.57%. The outbreak was successfully controlled by stringent infection control measures, especially improving the hand hygiene compliance and enhancing antimicrobial stewardship. In conclusion, this is the first description of an outbreak caused mainly by A. baumannii of ST208 in China. Infection control measures should be strengthened when infection outbreaks in hospital.

Henkilöstöjohtamisella vaikutusta työhyvinvointiin : Henkilöstöjohtamisen käsikirja tukena esimiestyön haasteissa

OpenAIRE

Viitasaari, Tuomas

2014-01-01

Yhteiskunnallisesti katsottuna työhyvinvointi on tärkeässä asemassa. Hyvällä johtamisella voidaan vaikuttaa työhyvinvointiin ja sen parantamiseen. Tässä opinnäytetyössä tutkitaan käytännön henkilöstöjohtamista ja henkilöstöjohtamisen käsikirjan merkitystä esimiestyössä. Opinnäytteeni ensimmäisenä tavoitteena on vastata siihen, mikä on hyvää henkilöstöjohtamista ja miten sitä voidaan tukea. Toinen tavoite on työpaikkani SPR Kontti kierrätystavarataloketjun toimeksiannon mukaisesti tutkia henki...

St. Anselm and Teaching

Science.gov (United States)

Evans, Gillian R.

1976-01-01

Discusses the educational principles and methods of the medieval philosopher and theologian, St. Anselm. Educational practices of medieval monastic schools, town schools, private tutors, and pastoral teaching are discussed. Available from: Taylor & Francis Ltd., P.O. Box 9137, Church Street Station, New York, N.Y. 10049. (Author/DB)

Using SDI-12 with ST microelectronics MCU's

Energy Technology Data Exchange (ETDEWEB)

Saari, Alexandra [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hinzey, Shawn Adrian [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Frigo, Janette Rose [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Proicou, Michael Chris [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Borges, Louis [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2015-09-03

ST Microelectronics microcontrollers and processors are readily available, capable and economical processors. Unfortunately they lack a broad user base like similar offerings from Texas Instrument, Atmel, or Microchip. All of these devices could be useful in economical devices for remote sensing applications used with environmental sensing. With the increased need for environmental studies, and limited budgets, flexibility in hardware is very important. To that end, and in an effort to increase open support of ST devices, I am sharing my teams' experience in interfacing a common environmental sensor communication protocol (SDI-12) with ST devices.

Methicillin-Resistant Staphylococcus aureus ST398 from Human Patients, Upper Austria

Science.gov (United States)

Metz-Gercek, Sigrid; Mittermayer, Helmut

2009-01-01

Methicillin-resistant Staphylococcus aureus (MRSA) clonal type ST398 is usually associated with animals. We examined 1,098 confirmed MRSA samples from human patients and found that 21 were MRSA ST398. Most (16) patients were farmers. Increasing prevalence from 1.3% (2006) to 2.5% (2008) shows emergence of MRSA ST398 in humans in Austria. PMID:19402964

The mean, the median, and the St. Petersburg paradox

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Benjamin Y. Hayden

2009-06-01

Full Text Available The St.~Petersburg Paradox is a famous economic and philosophical puzzle that has generated numerous conflicting explanations. To shed empirical light on this phenomenon, we examined subjects' bids for one St.~Petersburg gamble with a real monetary payment. We found that bids were typically lower than twice the smallest payoff, and thus much lower than is generally supposed. We also examined bids offered for several hypothetical variants of the St.~Petersburg Paradox. We found that bids were weakly affected by truncating the gamble, were strongly affected by repeats of the gamble, and depended linearly on the initial ``seed'' value of the gamble. One explanation, which we call the extit{median} extit{heuristic}, strongly predicts these data. Subjects following this strategy evaluate a gamble as if they were taking the median rather than the mean of the payoff distribution. Finally, we argue that the distribution of outcomes embodied in the St.~Petersburg paradox is so divergent from the Gaussian form that the statistical mean is a poor estimator of expected value, so that the expected value of the St.~Petersburg gamble is undefined. These results suggest that this classic paradox has a straightforward explanation rooted in the use of a statistical heuristic.

Reduction of st segment elevation in diabetic patients with myocardial infarction after thrombolytic therapy

International Nuclear Information System (INIS)

Syed, U.

2017-01-01

Acute coronary artery disease (CAD) is one of the main cause of death in today's world. Myocardial infarction (MI) tends to be more common among diabetic patients. One of the most effective and used (in our settings) methods of resolution of MI is administration of streptokinase (SK). This study was conducted with the aim to determine the efficacy of thrombolytic therapy in reduction of ST segment elevation in acute MI patients presenting with diabetes. Methods: A descriptive case series with selection of 130 patients through non-probability purposive sampling was conducted at the Medical Departments of Services Hospital Lahore. The study was completed in 6 Months. Patients 18-80 years of age having either gender diagnosed with confirmed acute myocardial infarction were included in this study. All patients were then injected with streptokinase 1.5 mu. Pre and Post SK ECGs were done and ST segment elevation measured also measuring reduction of ST segment. Results: The mean age of the patients was noted as 54.42+-8.80 years. There were 62.31% males. Mean reduction in ST-segment elevation of the patients was noted as 58.53+-26.01. The efficacy was achieved in 47.7% patients. Conclusion: It is concluded that SK can be effective in almost half of diabetic patients with myocardial infarction. (author)

77 FR 46516 - Notice of Availability of the Final Environmental Impact Statement, Including a Programmatic...

Science.gov (United States)

2012-08-03

... Impact Statement, Including a Programmatic Agreement, for the Clark, Lincoln, and White Pine Counties...) has prepared a Final Environmental Impact Statement (EIS) and a Programmatic Agreement (PA), which is.... 100 N., Nephi Beaver Library, 55 W. Center St., Beaver FOR FURTHER INFORMATION CONTACT: Penny Woods...

76 FR 34097 - Notice of Availability of the Draft Environmental Impact Statement, Including a Draft...

Science.gov (United States)

2011-06-10

... Impact Statement, Including a Draft Programmatic Agreement, for the Clark, Lincoln, and White Pine...) has prepared a Draft Environmental Impact Statement (EIS) and a Draft Programmatic Agreement (PA.... 100 N., Nephi Beaver Library, 55 W. Center St., Beaver. The Draft EIS describes and analyzes SNWA's...

Revisão e análise cladística de Serdia Stål (Heteroptera, Pentatomidae, Pentatomini Review and cladistic analysis of Serdia Stål (Heteroptera, Pentatomidae, Pentatomini

Directory of Open Access Journals (Sweden)

Nora Denise Fortes de Fortes

2005-09-01

Full Text Available Treze espécies são hoje incluídas no gênero: S. apicicornis, Stål, 1860; S. beckerae Thomas & Rolston, 1985; S. calligera Stål, 1860; S. concolor Ruckes, 1958; S. costalis Ruckes, 1958; S. delphis Thomas & Rolston, 1985; S. inspersipes Stål, 1860; S. lobata Thomas & Rolston, 1985; S. rotundicornis Becker, 1967 e S. ruckesi Thomas & Rolston, 1985. Cinco novas espécies são descritas: S. indistincta sp. nov (Irai, Rio Grande do Sul, S. bicolor sp. nov (Ponta Grossa, Paraná, S. maculata sp. nov (Itatiaia, Rio de Janeiro, S. máxima sp. nov (Imbituba, Santa Catarina e S. robusta sp. nov (Itatiaia, Rio de Janeiro do Brasil. A análise cladística foi realizada usando 40 caracteres e 21 táxons. O gênero Tibilis Stål, 1860; Neotibilis Grazia & Barcellos, 1994 e Similliserdia Fortes & Grazia, 1998 foram usados como grupo-externo. A monofilia de Serdia foi sustentada por 3 sinapomorfias: ápice do escutelo com margens enegrecidas, machos com a parede da taça genital espessada com processos em aba, fêmeas com o espessamento da íntima vaginal situado na metade posterior das gonapófises 9 e projetando-se ventralmente. O subgênero Brasiliicola Kirkaldy, 1909 é considerado sinônimo junior de Serdia. São fornecidas ilustrações, mapas de distribuição geográfica e chave para as espécies.Thirteen species are presently included in the genus: S. apicicornis Stål, 1860; S. beckerae Thomas & Rolston, 1985; S. bihamulata, Thomas & Rolston, 1985; S. calligera Stål, 1860; S. concolor Ruckes, 1958; S. costalis Ruckes, 1958; S. delphis Thomas & Rolston, 1985; S. inspersipes Stål, 1860; S. limbatipennis Stål, 1860; S. lobata Thomas & Rolston, 1985; S. quadridens Thomas & Rolston, 1985; S. rotundicornis Becker, 1967, and S. ruckesi Thomas & Rolston, 1985. Five new species are described: S.indistincta sp. nov. (Iraí; Rio Grande do Sul, S. bicolor sp. nov. (Ponta Grossa; Paraná S. maculata sp. nov. (Itatiaia; Rio de Janeiro S. maxima sp. nov

Parametric decadal climate forecast recalibration (DeFoReSt 1.0

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A. Pasternack

2018-01-01

Full Text Available Near-term climate predictions such as decadal climate forecasts are increasingly being used to guide adaptation measures. For near-term probabilistic predictions to be useful, systematic errors of the forecasting systems have to be corrected. While methods for the calibration of probabilistic forecasts are readily available, these have to be adapted to the specifics of decadal climate forecasts including the long time horizon of decadal climate forecasts, lead-time-dependent systematic errors (drift and the errors in the representation of long-term changes and variability. These features are compounded by small ensemble sizes to describe forecast uncertainty and a relatively short period for which typically pairs of reforecasts and observations are available to estimate calibration parameters. We introduce the Decadal Climate Forecast Recalibration Strategy (DeFoReSt, a parametric approach to recalibrate decadal ensemble forecasts that takes the above specifics into account. DeFoReSt optimizes forecast quality as measured by the continuous ranked probability score (CRPS. Using a toy model to generate synthetic forecast observation pairs, we demonstrate the positive effect on forecast quality in situations with pronounced and limited predictability. Finally, we apply DeFoReSt to decadal surface temperature forecasts from the MiKlip prototype system and find consistent, and sometimes considerable, improvements in forecast quality compared with a simple calibration of the lead-time-dependent systematic errors.

Parametric decadal climate forecast recalibration (DeFoReSt 1.0)

Science.gov (United States)

Pasternack, Alexander; Bhend, Jonas; Liniger, Mark A.; Rust, Henning W.; Müller, Wolfgang A.; Ulbrich, Uwe

2018-01-01

Near-term climate predictions such as decadal climate forecasts are increasingly being used to guide adaptation measures. For near-term probabilistic predictions to be useful, systematic errors of the forecasting systems have to be corrected. While methods for the calibration of probabilistic forecasts are readily available, these have to be adapted to the specifics of decadal climate forecasts including the long time horizon of decadal climate forecasts, lead-time-dependent systematic errors (drift) and the errors in the representation of long-term changes and variability. These features are compounded by small ensemble sizes to describe forecast uncertainty and a relatively short period for which typically pairs of reforecasts and observations are available to estimate calibration parameters. We introduce the Decadal Climate Forecast Recalibration Strategy (DeFoReSt), a parametric approach to recalibrate decadal ensemble forecasts that takes the above specifics into account. DeFoReSt optimizes forecast quality as measured by the continuous ranked probability score (CRPS). Using a toy model to generate synthetic forecast observation pairs, we demonstrate the positive effect on forecast quality in situations with pronounced and limited predictability. Finally, we apply DeFoReSt to decadal surface temperature forecasts from the MiKlip prototype system and find consistent, and sometimes considerable, improvements in forecast quality compared with a simple calibration of the lead-time-dependent systematic errors.

Fossil fuels in the 21st century.

Science.gov (United States)

Lincoln, Stephen F

2005-12-01

An overview of the importance of fossil fuels in supplying the energy requirements of the 21st century, their future supply, and the impact of their use on global climate is presented. Current and potential alternative energy sources are considered. It is concluded that even with substantial increases in energy derived from other sources, fossil fuels will remain a major energy source for much of the 21st century and the sequestration of CO2 will be an increasingly important requirement.

Buildings for the 21st Century, Fall 2001

Energy Technology Data Exchange (ETDEWEB)

2001-10-01

The Buildings for the 21st Century newsletter is produced by the Office of Building Technology, State and Community Programs and contains information on building programs, events, products, and initiatives, with a focus on energy efficiency and renewable energy. The fall issue includes information on weatherization, Boise's geothermal heating system, the BTS Core Databook, the Solar Decathlon, a Rebuild America partnership, the BigHorn Home Improvement Center, AIA's Top Ten Buildings, a sub-CFL procurement program, the U.S. investment in energy efficient research, new efficiency standards, PNNL's building software, and a calendar of meetings and conferences.

Guided Educational Tourism as Informal Physical Geography Education on St. Helena Island, Michigan

Science.gov (United States)

Lane, Joseph M.; Stoltman, Joseph P.

2017-01-01

Guided educational tours are a major activity within informal education. This article examines the potential for tour guides of a largely historical tour of St. Helena Island, Michigan, to include physical geography within the tour. Using field data and interview methods, the researchers identified the physical features of the island that could be…

St. John's wort impairs glucose tolerance by reducing insulin response in healthy men

DEFF Research Database (Denmark)

Stage, Tore Bjerregaard; Damkier, Per; Christensen, Mette Marie Hougaard

2015-01-01

The purpose of this study was to examine if the over-the-counter herbal medicinal plant St. John's wort affects glucose tolerance in healthy men. To do this, we included 10 healthy men who were examined by a 2-hr oral glucose tolerance test on three occasions; A: Baseline, B: After 21 days...

St. Lawrence action plan meter

Energy Technology Data Exchange (ETDEWEB)

NONE

1992-12-31

The purpose of this bulletin is to report on the progress achieved under the St. Lawrence Action Plan. Under each of the Action Plan`s five objectives, it outlines environmental management indicators which identify actions taken and shows the results. This report presents the data collected in late August 1992 on the activities carried out by all partners of both governments involved in SLAP. The objectives examined in the bulletin are: to reduce by 90% the liquid toxic waste discharged by the 50 plants targeted for priority action; to prepare remediation plans for contaminated federal sites and restore wetlands; to conserve 5000 additional hectares of habitat and create a marine park; to develop and implement recovery plans for mammals, fish, birds, amphibians, reptiles, and plants; and to determine the state of the St. Lawrence River.

Genomic investigation of a suspected outbreak of legionella pneumophila st82 reveals undetected heterogeneity by the present gold-standard methods, denmark, july to november 2014

DEFF Research Database (Denmark)

Schjørring, Susanne; Stegger, M.; Kjelsø, C.

2017-01-01

Between July and November 2014, 15 communityacquired cases of Legionnaires’ disease (LD), including four with Legionella pneumophila serogroup 1 sequence type (ST) 82, were diagnosed in Northern Zealand, Denmark. An outbreak was suspected. No ST82 isolates were found in environmental samples and ...

Teaching and Learning Jewish History in the 21st Century: New Priorities and Opportunities

Science.gov (United States)

Jacobs, Benjamin M.

2018-01-01

New 21st-century circumstances in the Jewish world--including the changing nature of Jewish identification, the retreat from identity and continuity as singular aims of Jewish education, the democratization of Jewish learning opportunities, increased emphasis on informal and experiential Jewish education activities, and demonstrable interest among…

The 21st century skills with model eliciting activities on linear program

Science.gov (United States)

Handajani, Septriana; Pratiwi, Hasih; Mardiyana

2018-04-01

Human resources in the 21st century are required to master various forms of skills, including critical thinking skills and problem solving. The teaching of the 21st century is a teaching that integrates literacy skills, knowledge, skills, attitudes, and mastery of ICT. This study aims to determine whether there are differences in the effect of applying Model Elliciting Activities (MEAs) that integrates 21st century skills, namely 4C and conventional learning to learning outcomes. This research was conducted at Vocational High School in the odd semester of 2017 and uses the experimental method. The experimental class is treated MEAs that integrates 4C skills and the control class is given conventional learning. Methods of data collection in this study using the method of documentation and test methods. The data analysis uses Z-test. Data obtained from experiment class and control class. The result of this study showed there are differences in the effect of applying MEAs that integrates 4C skills and conventional learning to learning outcomes. Classes with MEAs that integrates 4C skills give better learning outcomes than the ones in conventional learning classes. This happens because MEAs that integrates 4C skills can improved creativity skills, communication skills, collaboration skills, and problem-solving skills.

Pathogenicity of Human ST23 Streptococcus agalactiae to Fish and Genomic Comparison of Pathogenic and Non-pathogenic Isolates

Directory of Open Access Journals (Sweden)

Rui Wang

2017-10-01

Full Text Available Streptococcus agalactiae, or Group B Streptococcus (GBS, is a major pathogen causing neonatal sepsis and meningitis, bovine mastitis, and fish meningoencephalitis. CC23, including its namesake ST23, is not only the predominant GBS strain derived from human and cattle, but also can infect a variety of homeothermic and poikilothermic species. However, it has never been characterized in fish. This study aimed to determine the pathogenicity of ST23 GBS to fish and explore the mechanisms causing the difference in the pathogenicity of ST23 GBS based on the genome analysis. Infection of tilapia with 10 human-derived ST23 GBS isolates caused tissue damage and the distribution of pathogens within tissues. The mortality rate of infection was ranged from 76 to 100%, and it was shown that the mortality rate caused by only three human isolates had statistically significant difference compared with fish-derived ST7 strain (P < 0.05, whereas the mortality caused by other seven human isolates did not show significant difference compared with fish-derived ST7 strain. The genome comparison and prophage analysis showed that the major genome difference between virulent and non-virulent ST23 GBS was attributed to the different prophage sequences. The prophage in the P1 region contained about 43% GC and encoded 28–39 proteins, which can mediate the acquisition of YafQ/DinJ structure for GBS by phage recombination. YafQ/DinJ belongs to one of the bacterial toxin–antitoxin (TA systems and allows cells to cope with stress. The ST23 GBS strains carrying this prophage were not pathogenic to tilapia, but the strains without the prophage or carrying the pophage that had gene mutation or deletion, especially the deletion of YafQ/DinJ structure, were highly pathogenic to tilapia. In conclusion, human ST23 GBS is highly pathogenic to fish, which may be related to the phage recombination.

Influence of ST-segment recovery on infarct size and ejection fraction in patients with ST-segment elevation myocardial infarction receiving primary percutaneous coronary intervention

DEFF Research Database (Denmark)

Hallén, Jonas; Ripa, Maria Sejersten; Johanson, Per

2010-01-01

In patients with ST-segment elevation myocardial infarction treated with fibrinolytics, electrocardiogram-derived measures of ST-segment recovery guide therapy decisions and predict infarct size. The comprehension of these relationships in patients undergoing mechanical reperfusion is limited. We...

Examining the 21st Century Classroom: Developing an Innovation Configuration Map

Science.gov (United States)

Donovan, Loretta; Green, Tim D.; Mason, Candice

2014-01-01

Despite it being the second decade of the 21st century, there still exists a range of definitions of what a 21st century learning environment is. This can be troublesome for teacher educators as we strive to prepare teachers for environments we can't clearly describe. In order to describe a 21st century learning environment, we developed an IC Map…

The Dynamic Role of the IL-33/ST2 Axis in Chronic Viral-infections: Alarming and Adjuvanting the Immune Response

Directory of Open Access Journals (Sweden)

Vikram Mehraj

2016-07-01

Search Strategy and Selection Criteria: English language, indexed publications in PubMed were searched using combinations of following key words: “interleukin-33”, “IL-33”, “suppression of tumorigenicity 2”, ST2”, “sST2”, “HIV”, “HBV”, “HCV”, “CMV”, “HPV”, “immunotherapy” and “vaccine”. Except for seminal studies, only articles published between 2010 and 2016 were included.

Cleavage of ST6Gal I by Radiation-Induced BACE1 Inhibits Golgi-Anchored ST6Gal I-Mediated Sialylation of Integrin β1 and Migration in Colon Cancer Cells

International Nuclear Information System (INIS)

Lee, Minyoung; Park, Jung-Jin; Ko, Young-Gyu; Lee, Yun-Sil

2012-01-01

Previously, we found that β-galactoside α2,6-sialyltransferase (ST6Gal I), an enzyme that adds sialic acids to N-linked oligosaccharides of glycoproteins and is frequently overexpressed in cancer cells, is up-regulated by ionizing radiation (IR) and cleaved to a form possessing catalytic activity comparable to that of the Golgi-localized enzyme. Moreover, this soluble form is secreted into the culture media. Induction of ST6Gal I significantly increased the migration of colon cancer cells via sialylation of integrin β1. Here, we further investigated the mechanisms underlying ST6Gal I cleavage, solubilization and release from cells, and addressed its functions, focusing primarily on cancer cell migration. We performed immunoblotting and lectin affinity assay to analyze the expression of ST6 Gal I and level of sialylated integrin β1. After ionizing radiation, migration of cells was measured by in vitro migration assay. α2, 6 sialylation level of cell surface was analyzed by flow cytometry. Cell culture media were concentrated and then analyzed for soluble ST6Gal I levels using an α2, 6 sialyltransferase sandwich ELISA. We found that ST6Gal I was cleaved by BACE1 (β-site amyloid precursor protein-cleaving enzyme), which was specifically overexpressed in response to IR. The soluble form of ST6Gal I, which also has sialyltransferase enzymatic activity, was cleaved from the Golgi membrane and then released into the culture media. Both non-cleaved and cleaved forms of ST6Gal I significantly increased colon cancer cell migration in a sialylation-dependent manner. The pro-migratory effect of the non-cleaved form of ST6Gal I was dependent on integrin β1 sialylation, whereas that of the cleaved form of ST6Gal I was not, suggesting that other intracellular sialylated molecules apart from cell surface molecules such as integrin β1 might be involved in mediating the pro-migratory effects of the soluble form of ST6Gal I. Moreover, production of soluble form ST6Gal I by

Particulate Air Pollution as a Risk Factor for ST-segment Depression in Patients with Coronary Artery Disease

Science.gov (United States)

Chuang, Kai Jen; Coull, Brent A.; Zanobetti, Antonella; Suh, Helen; Schwartz, Joel; Stone, Peter H.; Litonjua, Augusto; Speizer, Frank E.; Gold, Diane R.

2009-01-01

Background The association of particulate matter (PM) with cardiovascular morbidity and mortality is well documented. PM-induced ischemia is considered a potential mechanism linking PM to adverse cardiovascular outcomes. Methods and Results In a repeated-measures study including 5,979 observations on 48 patients aged 43–75 years, we investigated associations of ambient pollution with ST-segment level changes averaged over half-hour periods, measured in the modified V5 position by 24-hr Holter electrocardiogram monitoring. Each patient was observed up to 4 times within one year after a percutaneous intervention for myocardial infarction, acute coronary syndrome without infarction, or stable coronary artery disease without acute coronary syndrome. Elevation in fine particles (PM2.5) and black carbon (BC) levels predicted depression of half-hour averaged ST-segment levels. An interquartile increase in the previous 24-h mean BC level was associated with a 1.50-fold increased in risk of ST-segment depression ≥0.1 mm (95% CI: 1.19, 1.89) and a −0.031 mm (95% CI: −0.042, −0.019) decrease in half-hour averaged ST-segment level (continuous outcome). Effects were greatest within the first month after hospitalization, and for patients with myocardial infarction during hospitalization or with diabetes. Conclusions ST-segment depression is associated with increased exposure to PM2.5 and BC in cardiac patients. The risk of pollution-associated ST-segment depression may be greatest in those with myocardial injury in the first month after the cardiac event. PMID:18779445

Influence of ST-segment recovery on infarct size and ejection fraction in patients with ST-segment elevation myocardial infarction receiving primary percutaneous coronary intervention

DEFF Research Database (Denmark)

Hallén, Jonas; Ripa, Maria Sejersten; Johanson, Per

2010-01-01

percutaneous coronary intervention. Three methods for calculating and categorizing ST-segment recovery were used: (1) summed ST-segment deviation (STD) resolution analyzed in 3 categories (> or = 70%, > or = 30% to or = 2 mm). Infarct size and ejection fraction were assessed at 4 months by cardiac magnetic...... resonance imaging. All 3 ST-segment recovery algorithms predicted the final infarct size and cardiac function. Worst-lead residual STD performed the same as, or better than, the more complex methods and identified large subgroups at either end of the risk spectrum (median infarct size from the lowest...

Evolutionary history of the alpha2,8-sialyltransferase (ST8Sia) gene family: tandem duplications in early deuterostomes explain most of the diversity found in the vertebrate ST8Sia genes.

Science.gov (United States)

Harduin-Lepers, Anne; Petit, Daniel; Mollicone, Rosella; Delannoy, Philippe; Petit, Jean-Michel; Oriol, Rafael

2008-09-23

The animal sialyltransferases, which catalyze the transfer of sialic acid to the glycan moiety of glycoconjugates, are subdivided into four families: ST3Gal, ST6Gal, ST6GalNAc and ST8Sia, based on acceptor sugar specificity and glycosidic linkage formed. Despite low overall sequence identity between each sialyltransferase family, all sialyltransferases share four conserved peptide motifs (L, S, III and VS) that serve as hallmarks for the identification of the sialyltransferases. Currently, twenty subfamilies have been described in mammals and birds. Examples of the four sialyltransferase families have also been found in invertebrates. Focusing on the ST8Sia family, we investigated the origin of the three groups of alpha2,8-sialyltransferases demonstrated in vertebrates to carry out poly-, oligo- and mono-alpha2,8-sialylation. We identified in the genome of invertebrate deuterostomes, orthologs to the common ancestor for each of the three vertebrate ST8Sia groups and a set of novel genes named ST8Sia EX, not found in vertebrates. All these ST8Sia sequences share a new conserved family-motif, named "C-term" that is involved in protein folding, via an intramolecular disulfide bridge. Interestingly, sequences from Branchiostoma floridae orthologous to the common ancestor of polysialyltransferases possess a polysialyltransferase domain (PSTD) and those orthologous to the common ancestor of oligosialyltransferases possess a new ST8Sia III-specific motif similar to the PSTD. In osteichthyans, we have identified two new subfamilies. In addition, we describe the expression profile of ST8Sia genes in Danio rerio. Polysialylation appeared early in the deuterostome lineage. The recent release of several deuterostome genome databases and paralogons combined with synteny analysis allowed us to obtain insight into events at the gene level that led to the diversification of the ST8Sia genes, with their corresponding enzymatic activities, in both invertebrates and vertebrates. The

Evolutionary history of the alpha2,8-sialyltransferase (ST8Sia gene family: Tandem duplications in early deuterostomes explain most of the diversity found in the vertebrate ST8Sia genes

Directory of Open Access Journals (Sweden)

Petit Jean-Michel

2008-09-01

Full Text Available Abstract Background The animal sialyltransferases, which catalyze the transfer of sialic acid to the glycan moiety of glycoconjugates, are subdivided into four families: ST3Gal, ST6Gal, ST6GalNAc and ST8Sia, based on acceptor sugar specificity and glycosidic linkage formed. Despite low overall sequence identity between each sialyltransferase family, all sialyltransferases share four conserved peptide motifs (L, S, III and VS that serve as hallmarks for the identification of the sialyltransferases. Currently, twenty subfamilies have been described in mammals and birds. Examples of the four sialyltransferase families have also been found in invertebrates. Focusing on the ST8Sia family, we investigated the origin of the three groups of α2,8-sialyltransferases demonstrated in vertebrates to carry out poly-, oligo- and mono-α2,8-sialylation. Results We identified in the genome of invertebrate deuterostomes, orthologs to the common ancestor for each of the three vertebrate ST8Sia groups and a set of novel genes named ST8Sia EX, not found in vertebrates. All these ST8Sia sequences share a new conserved family-motif, named "C-term" that is involved in protein folding, via an intramolecular disulfide bridge. Interestingly, sequences from Branchiostoma floridae orthologous to the common ancestor of polysialyltransferases possess a polysialyltransferase domain (PSTD and those orthologous to the common ancestor of oligosialyltransferases possess a new ST8Sia III-specific motif similar to the PSTD. In osteichthyans, we have identified two new subfamilies. In addition, we describe the expression profile of ST8Sia genes in Danio rerio. Conclusion Polysialylation appeared early in the deuterostome lineage. The recent release of several deuterostome genome databases and paralogons combined with synteny analysis allowed us to obtain insight into events at the gene level that led to the diversification of the ST8Sia genes, with their corresponding enzymatic

Bulding and Ornamental Stone in the History of St Petersburg Architecture

Science.gov (United States)

Bulakh, Andrey

2013-04-01

First, the Our Lady of Kazan Orthodox Cathedral and some mansions are used to demonstrate Russian stones in the architectural décor of St Petersburg, XVIII-XX cc. These rocks are granites from Vyborg and Sortavala, lime tufa from Gatchina, marbles from Ruskeala and Juven at the Ladoga Lake, Tivdian marble, Shokshian quartzite, and black aspid slate of the Onega Lake. Later German and Polish sandstones and Finnish soap stone came to the city. Second, there is given a review of rock types used in St Petersburg at XX-XXI cc. margins. They are granites, granosyenites, syenites, gneisses, marbles, limestones both from Russia and from abroad. Which ones are more usual? From what regions did Russian stone come? References: 1) A.G.Bulakh, N.B.Abakumova, J.V.Romanovsky. St Petersburg: a History in Stone. 2010. Print. House of St Petersburg State University. 173 p. 2) A.Ya. Tutakova, A.Z. Romanovskiy, A.G. Bulakh, V.I. Leer. Dimension Stone of the Leningrad Region. Granites of the Karelia Isthmus in Architecture of the Modern St Petersburg. 2011. St Petersburg. 78 p. (In Russian).

Simple stålrammebygninger

DEFF Research Database (Denmark)

Ellum, J.C.; Buhelt, M.

Ved en simpel stålrammebygning forstås i anvisningen en lukket, fritliggende bygning i én etage, hvor tagkonstruktionen ud over egenlast kun er påvirket af naturlaster, dvs. sne og vind. Dimensioneringen af de bærende konstruktioner gennemføres ved at benytte publikationens omfattende tabeldata o...

The structural features of the sulfated heteropolysaccharide (ST-1) from Sargassum thunbergii and its neuroprotective activities.

Science.gov (United States)

Jin, Weihua; Liu, Bing; Li, Shuai; Chen, Jing; Tang, Hong; Jiang, Di; Zhang, Quanbin; Zhong, Weihong

2018-03-01

Polysaccharide (ST) was prepared from Sargassum thunbergii using hot water. Two fractions (ST-1 and ST-2) were prepared using anion exchange chromatography. One desulfated polysaccharide (ST-1-DS) was also prepared. Electrospray ionization mass spectrometry (ESI-MS) performed on ST-1-DS showed that the desulfated polysaccharides contained methyl glycosides of mono-sulfated and di-sulfated galacto-fucooligosaccharides. This result suggested that ST-1 might contain sulfated galactofucan, which consists of a backbone of alternating (Gal) n and (Fuc) n and sulfated randomly on Gal and mainly on C-2 in Fuc. In addition, ST-1 was degraded in 1M sulfuric acid. The solution was centrifuged, and the supernatant was concentrated and precipitated in ethanol to obtain the precipitate (ST-1-P). ST-1-P was then separated using gel chromatography and anion exchange chromatography to obtain the oligomers. ESI-MS spectra of oligomers indicated that ST-1 mostly contained sulfated glucuronomannan and fucoglucuronan. ESI-MS with collision-induced dissociation tandem mass spectrometry (ESI-CID-MS/MS) suggested that glucuronomannan contained alternating 2-linked Man and 4-linked GlcA, while fucoglucuronan contained 4-linked glucuronan with branched Fuc at C-3. Finally, the neuroprotective activities of ST, ST-1, ST-2 and MIX (a mixture of ST-1 and ST-2) were determined. ST showed the most neuroprotective activity, which indicated that ST might be a good candidate for curing neurodegenerative diseases. Copyright © 2017 Elsevier B.V. All rights reserved.

Areal distribution and concentration of contaminants of concern in surficial streambed and lakebed sediments, Lake St. Clair and tributaries, Michigan, 1990-2003

Science.gov (United States)

Rachol, Cynthia M.; Button, Daniel T.

2006-01-01

As part of the Lake St. Clair Regional Monitoring Project, the U.S. Geological Survey evaluated data collected from surficial streambed and lakebed sediments in the Lake Erie-Lake St. Clair drainages. This study incorporates data collected from 1990 through 2003 and focuses primarily on the U.S. part of the Lake St. Clair Basin, including Lake St. Clair, the St. Clair River, and tributaries to Lake St. Clair. Comparable data from the Canadian part of the study area are included where available. The data are compiled into 4 chemical classes and consist of 21 compounds. The data are compared to effects-based sediment-quality guidelines, where the Threshold Effect Level and Lowest Effect Level represent concentrations below which adverse effects on biota are not expected and the Probable Effect Level and Severe Effect Level represent concentrations above which adverse effects on biota are expected to be frequent.Maps in the report show the spatial distribution of the sampling locations and illustrate the concentrations relative to the selected sediment-quality guidelines. These maps indicate that sediment samples from certain areas routinely had contaminant concentrations greater than the Threshold Effect Concentration or Lowest Effect Level. These locations are the upper reach of the St. Clair River, the main stem and mouth of the Clinton River, Big Beaver Creek, Red Run, and Paint Creek. Maps also indicated areas that routinely contained sediment contaminant concentrations that were greater than the Probable Effect Concentration or Severe Effect Level. These locations include the upper reach of the St. Clair River, the main stem and mouth of the Clinton River, Red Run, within direct tributaries along Lake St. Clair and in marinas within the lake, and within the Clinton River headwaters in Oakland County.Although most samples collected within Lake St. Clair were from sites adjacent to the mouths of its tributaries, samples analyzed for trace-element concentrations

Formerly utilized MED/AEC sites Remedial Action Program. Radiological survey of the St. Louis Airport Storage Site, St. Louis, Missouri. Final report. [U, Ra-bearing wastes stored in 1940-60's

Energy Technology Data Exchange (ETDEWEB)

None

1979-09-01

Results of two radiological surveys of the St. Louis-Lambert Airport property, formerly known as the Airport Storage Site, St. Louis, Missouri, are presented. Uranium- and radium-bearing waste materials were stored from the 1940's to the late 1960's in this area. The surveys included direct measurements of beta-gamma radiation; determination of uranium, actinium, and radium concentrations in soil samples and from bore holes; determination of radionuclide concentrations in groundwater and surface water; measurement of radon flux from the ground surface; and measurements of /sup 222/Rn in air near the site. Results indicate that some offsite drainage pathways are becoming contaminated, probably by runoff from the site; no migration of /sup 222/Rn from the site was observed.

Evidence-based toxicology for the 21st century: opportunities and challenges.

Science.gov (United States)

Stephens, Martin L; Andersen, Melvin; Becker, Richard A; Betts, Kellyn; Boekelheide, Kim; Carney, Ed; Chapin, Robert; Devlin, Dennis; Fitzpatrick, Suzanne; Fowle, John R; Harlow, Patricia; Hartung, Thomas; Hoffmann, Sebastian; Holsapple, Michael; Jacobs, Abigail; Judson, Richard; Naidenko, Olga; Pastoor, Tim; Patlewicz, Grace; Rowan, Andrew; Scherer, Roberta; Shaikh, Rashid; Simon, Ted; Wolf, Douglas; Zurlo, Joanne

2013-01-01

The Evidence-based Toxicology Collaboration (EBTC) was established recently to translate evidence-based approaches from medicine and health care to toxicology in an organized and sustained effort. The EBTC held a workshop on "Evidence-based Toxicology for the 21st Century: Opportunities and Challenges" in Research Triangle Park, North Carolina, USA on January 24-25, 2012. The presentations largely reflected two EBTC priorities: to apply evidence-based methods to assessing the performance of emerging pathway-based testing methods consistent with the 2007 National Research Council report on "Toxicity Testing in the 21st Century" as well as to adopt a governance structure and work processes to move that effort forward. The workshop served to clarify evidence-based approaches and to provide food for thought on substantive and administrative activities for the EBTC. Priority activities include conducting pilot studies to demonstrate the value of evidence-based approaches to toxicology, as well as conducting educational outreach on these approaches.

Distribution of some radionuclides in the St. Lawrence estuary, Quebec, Canada

International Nuclear Information System (INIS)

Serodes, J.B.; Roy, J.C.

1983-01-01

The distribution of γ-emitting radionuclides in the St. Lawrence estuary was studied in 1978 and 1979, by means of double sampling and the flocculation and centrifugation of very large volumes of water. Eleven radionuclides were detected, originating from a variety of sources, including soil erosion and nuclear weapons testing. The concentrations measured in 1979 were higher than those of 1978; the 21st Chinese nuclear test could be responsible for the increase of some radionuclides. Concentrations decrease markedly from the freshwater part to the marine region of the estuary. Dilution by oceanic waters, relative affinity with suspended matter and radioactive decay are the principal mechanisms involved in the distribution patterns. Cesium-137, 144 Ce, 226 Ra, 228 Ra and 228 Th are strongly associated with suspended matter, while about two thirds of 7 Be, 106 Ru and 235 U are present in the liquid phase. Results suggest that 235 U is released from sediments in the maximum turbidity zone

Effective Leadership in the 21st Century.

Science.gov (United States)

Jones, Jacqueline

2015-01-01

Leaders know how to achieve goals and inspire people along the way. While the terms and definitions may change with the times, it is important to understand the skills and abilities needed to lead in the 21st century. Most effective leaders have one element in common, and that is they are able to keep their teams engaged. If team members are not engaged, they may very well leave the organization. With four generations in the workplace, leaders must adapt and modify their leadership style in order to maintain employee engagement. The ability to lead effectively is based on a number of skills, including communication, motivation, vision, modeling, demonstrating empathy, confidence, persistence, and integrity.

Characterization of staphylococci in urban wastewater treatment plants in Spain, with detection of methicillin resistant Staphylococcus aureus ST398

International Nuclear Information System (INIS)

Gómez, Paula; Lozano, Carmen; Benito, Daniel; Estepa, Vanesa; Tenorio, Carmen; Zarazaga, Myriam; Torres, Carmen

2016-01-01

Staphylococcus spp. are normal contaminants of urban wastewater, including different lineages of S. aureus and a high diversity of coagulase-negative species. The presence of multiple resistance and virulence genes, including mecA, in staphylococci of wastewater can be a concern for the public health. - Highlights: • High prevalence of Staphylococcus spp. in pre- and post-treatment wastewater in UWTPs. • First report of MRSA-ST398 in urban wastewater, and of the spa types: t605, t878, and t3262. • High diversity of coagulase-negative Staphylococcus species, and high content in resistance genes. • Detection of enterotoxin genes in S. aureus and unusual antibiotic resistance genes in coagulase-negative Staphylococcus. • Wastewater can contribute to the dissemination of Staphylococcus and their resistance and virulence genes to the environment. - A high diversity of multidrug-resistant staphylococci with high content in virulence genes were detected in influent and effluent UWTP samples, including the emergent lineage MRSA-ST398.

Detection of ST-T Episode Based on the Global Curvature of Isoelectric Level in ECG

Energy Technology Data Exchange (ETDEWEB)

Kang, D. W.; Jun, D. G.; Lee, K. J.; Yoon, H. R. [Yonsei University, Seoul (Korea)

2001-04-01

This paper describes an automated detection algorithm of ST-T episodes using global curvature which can connect the isoelectric level in ECG and can eliminate not only the slope of ST segment, but also difference of the baseline and global curve. This above method of baseline correction is very faster than classical baseline correction methods. The optimal values of parameters for baseline correction were found as the value having the highest detection rate of ST episode. The features as input of backpropagation Neural Network were extracted from the whole ST segment. The European ST-T database was used as training and test data. Finally, ST elevation, ST depression and normal ST were classified. The average ST episode sensitivity and predictivity were 85.42%, 80.29%, respectively. This result shows the high speed and reliability in ST episode detection. In conclusion, the proposed method showed the possibility in various applications for the Holter system. (author). 17 refs., 5 figs., 4 tabs.

Kalkgraslandvegetaties van de St. Pietersberg ten zuiden van Maastricht

NARCIS (Netherlands)

Willems, J.H.; Blanckenborg, F.G.

1975-01-01

In this publication the authors describe the grassland communities rich in species especially those which occur on basic soils. The investigation was done in the Belgian part as well as in the Dutch part of St. Pietersberg situated south of the Dutch town of Maastricht. See map – fig. 1. St.

Merging formation of FRC and its application to high-beta ST formation

International Nuclear Information System (INIS)

Ono, Y.; Inomoto, M.; Ueda, Y.; Matsuyama, T.; Ohshima, Y.; Katsurai, M.

2001-01-01

Merging formation of field-reversed configuration (FRC) explored not only a new scenario of highly-efficient FRC formation/amplification experiment but also a new boundary research between FRC, spheromak and spherical tokamak (ST). A new finding is that the produced FRC is transformed stably into an ultra-high-β ST by applying external toroidal field B t,ext . The toroidal field was observed to vanish around magnetic axis after the B t,ext application to the FRC, indicating formation of diamagnetic ST. The hollow current profile of FRC was maintained during the equilibrium transition, eliminating a need for the difficult hollow-current-formation process of start-up discharge of high-β ST. The energy-conversion effect of merging transformed the force-free merging spheromaks with paramagnetic current into the FRC with diamagnetic current and the further application of B t,ext did the FRC into the ultra-high-β (>60%)/diamagnetic ST, indicating the close relationship between FRC and ST in second stability. (author)

ST Elevation in AVR: When Time May Not Mean Muscle

Science.gov (United States)

2017-10-31

REPORT TYPE 1013112017 Presentation 4. TITLE AND SUBTITLE ST Elevation in AVR: When Thne May Not Mean !Vfu&cle 6. AUTHOR{S) Capt \\Villiam T...ACCF/AHA Guideline for the Management of ST -Elevation Myocardial Infarction A Report of the Arnerican College of C ardiology Foundation/ Ameri can...C7Q n ([) G) ro )::>t w :J r+ c.. < -· ro ti) ti) ro ti) OJ m ti) -ro n Take home points •Don’t ignore ST elevation in aVR •Look closely

Whole genome analysis of a livestock-associated methicillin-resistant Staphylococcus aureus ST398 isolate from a case of human endocarditis

Directory of Open Access Journals (Sweden)

van Strijp Jos AG

2010-06-01

Full Text Available Abstract Background Recently, a new livestock-associated methicillin-resistant Staphylococcus aureus (MRSA Sequence Type 398 (ST398 isolate has emerged worldwide. Although there have been reports of invasive disease in humans, MRSA ST398 colonization is much more common in livestock and demonstrates especially high prevalence rates in pigs and calves. The aim of this study was to compare the genome sequence of an ST398 MRSA isolate with other S. aureus genomes in order to identify genetic traits that may explain the success of this particular lineage. Therefore, we determined the whole genome sequence of S0385, an MRSA ST398 isolate from a human case of endocarditis. Results The entire genome sequence of S0385 demonstrated considerable accessory genome content differences relative to other S. aureus genomes. Several mobile genetic elements that confer antibiotic resistance were identified, including a novel composite of an type V (5C2&5 Staphylococcal Chromosome Cassette mec (SCCmec with distinct joining (J regions. The presence of multiple integrative conjugative elements combined with the absence of a type I restriction and modification system on one of the two νSa islands, could enhance horizontal gene transfer in this strain. The ST398 MRSA isolate carries a unique pathogenicity island which encodes homologues of two excreted virulence factors; staphylococcal complement inhibitor (SCIN and von Willebrand factor-binding protein (vWbp. However, several virulence factors such as enterotoxins and phage encoded toxins, including Panton-Valentine leukocidin (PVL, were not identified in this isolate. Conclusions Until now MRSA ST398 isolates did not cause frequent invasive disease in humans, which may be due to the absence of several common virulence factors. However, the proposed enhanced ability of these isolates to acquire mobile elements may lead to the rapid acquisition of determinants which contribute to virulence in human infections.

LiDAR Relative Reflectivity Surface (2011) for the St. Thomas East End Reserve, St. Thomas

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 0.3x0.3 meter resolution relative seafloor reflectivity surface for the St. Thomas East End Reserve...

"Vi er ikke støttepædagoer"

DEFF Research Database (Denmark)

Knudsen, Louise Stjerne

2014-01-01

Hvilket talent(udviklings)miljø har talentfulde gymnasieelever brug for, og hvordan ’plejer’ man dem bedst muligt, så de ikke føler, at de bliver ’støttepædagoger’?......Hvilket talent(udviklings)miljø har talentfulde gymnasieelever brug for, og hvordan ’plejer’ man dem bedst muligt, så de ikke føler, at de bliver ’støttepædagoger’?...

Staphylococcus aureus eye infections in two Indian hospitals: emergence of ST772 as a major clone

Directory of Open Access Journals (Sweden)

Nadig S

2012-01-01

Full Text Available Savitha Nadig1, Nithya Velusamy2, Prajna Lalitha2, Sarita Kar3, Savitri Sharma3, Gayathri Arakere11Society for Innovation and Development, Indian Institute of Science, Bengaluru, Karnataka, 2Aravind Eye Hospital, Madurai, Tamil Nadu, 3LV Prasad Eye Institute, Bhubaneswar, Odisha, IndiaPurpose: The purpose of this study was to perform molecular characterization of Staphylococcus aureus isolates causing a variety of eye infections from two major eye care hospitals in India.Methods: Twenty-four isolates from Aravind Eye Hospital, Madurai, India, and nine isolates from LV Prasad Eye Institute, Bhubaneswar, India, representing severe to nonsevere eye infections like microbial keratitis to lacrimal sac abscess, were characterized. Staphylococcal cassette chromosome mec typing, multilocus sequence typing, accessory gene regulator typing, staphylococcal protein A typing, and pulsed field gel electrophoresis were used, along with determination of the presence of Panton–Valentine leucocidin toxin and endotoxin gene cluster among each sequence type.Results: The majority of eye infections, both severe and nonsevere, were caused by sequence type (ST772, positive for the Panton–Valentine leucocidin gene, and carrying methicillin-resistant staphylococcal cassette chromosome mec type V cassette (22/33, 67%. Some of the other sequence types that caused severe eye infections were ST1 (9%, 5 (3%, 72 (6%, 88 (3%, 121 (3%, and 672 (3%. This is the first report of the presence of ST1 and 88 in India.Conclusion: Although the number of isolates included in this study was small, most of the eye infections were caused by community-associated S. aureus where patients had no history of hospitalization or treatment in the past year. In the case of six severe infections, patients were admitted for surgeries and there is probability of hospital infection. In addition, only methicillin-resistant S. aureus isolates carrying staphylococcal cassette chromosome mec type V were

The Danish St. Croix Project

DEFF Research Database (Denmark)

J. Douma, Michael; Rasmussen, Anders Bo

2014-01-01

H. Seward, commonly viewed as an anti-colonizationist, was at least a mild proponent of colonization in its earliest stages. The paper demonstrates further that in the summer of 1862 the St. Croix colonization project was an important stepping stone in the Lincoln administration’s legal......Working from previously unknown sources in Danish archives, this article establishes for the first time the important role that the island of St. Croix played in the Lincoln Administration’s considerations on colonizing African Americans abroad. The paper argues that U.S. Secretary of State William....... The substantial conclusion of the paper is that, contrary to earlier perceptions in the historiography, African American colonization during the Civil War was not led and directed entirely from Washington. Rather, in this case, the Danish minister proposed a colonization plan and then worked with the United...

46 CFR 7.85 - St. Simons Island, GA to Little Talbot Island, FL.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false St. Simons Island, GA to Little Talbot Island, FL. 7.85... BOUNDARY LINES Atlantic Coast § 7.85 St. Simons Island, GA to Little Talbot Island, FL. (a) A line drawn from latitude 31°04.1′ N. longitude 81°16.7′ W. (St. Simons Lighted Whistle Buoy “ST S”) to latitude 30...

Aligning Business and Education: 21st Century Skill Preparation

Science.gov (United States)

Campbell, Charles L., Jr.; Kresyman, Shelley

2015-01-01

The purpose of this paper is to explore stakeholder perceptions concerning four key 21st century skills required for graduates to be successful in today's workplace, and to report on common themes surrounding how a post-secondary school in the Southwest United States is preparing graduates with predominant 21st Century skills: interpersonal…

Preparing Students for the Future--21st Century Skills

Science.gov (United States)

Velez, Alejandra

2012-01-01

The 21st century economy is driven by information and communication technologies (ICT). This change has made innovation, manufacturing and production of products and services, rather than manufacturing of material goods, the driving force of economies of leading countries (Wagner, 2008). Due to this shift, today's 21st century society and…

Hmong Political Involvement in St. Paul, Minnesota and Fresno, California

Directory of Open Access Journals (Sweden)

Yang Lor

2010-01-01

Full Text Available Over the past several years, Hmong in the United States have gained prominence for their increasing involvement in politics. Most of the attention has understandably focused on Fresno, California and St. Paul, Minnesota, home to the two largest Hmong populations in this country. While the Hmong communities in both cities are similar in size and have made significant political progress as evidenced by the election of Hmong candidates, the Hmong community in St. Paul has made greater inroads in the political realm. In addition to the elections of two Hmong candidates to the Minnesota State Legislature and two to the St. Paul School Board, the Hmong community in St. Paul has been able to engage local and state governments in Minnesotato address issues that affect the Hmong community. Through interviews, census data, and newspaper coverage of political campaigns, I show that Hmong in St. Paul have achieved greaterrepresentation in local and state governments and received greater support from government officials than Hmong in Fresno because Minnesota offers a social, economic, and politicalcontext that is favorable to fostering Hmong political involvement. Compared to Hmong in Fresno, Hmong in St. Paul have higher levels of socioeconomic resources and are more visible given their large size relative to other minority groups. They live in a region with consistently high levels of political participation and have political candidates who devote resources to mobilizing the Hmong community. Moreover, the Hmong vote has been critical to the success of Hmong candidates in St. Paul, an indication of the increasing political clout of the Hmong community there and a major reason why politicians in Minnesota are more willing to respond toissues that affect the Hmong community. Overall, this study highlights the importance of local and regional context in understanding the political incorporation of immigrants.

The spirit of St. Lucie: nuclear plant built on schedule

International Nuclear Information System (INIS)

Derrickson, W.B.

1984-01-01

Florida Power and Light Company currently has four nuclear units in operation with St. Lucie Unit 2 being the last to receive an operating license in June, 1983. It's sister Unit 1 received its license in 1976 and has, through 1982, compiled one of the best operating records in the United States. The full power license for St. Lucie Unit 2 was received from the Nuclear Regulatory Commission (NRC) on June 10, 1983, just six years after construction began. The industry average for construction of nuclear plants in this time period is about 10 years. The success of the St. Lucie Unit 2 project can be at least in part attributed to planning the work, accurate and timely reporting of results via valid indicators, well trained and skilled personnel, and most of all, teamwork. During the course of the project the plant was constantly on or near schedule and always ahead of industry averages. This was done despite issuance of numerous regulations by the NRC (TMI), a 1979 hurricane which did considerable damage to the Reactor Auxiliary Building, labor problems, and an NRC schedule review team that determined the best that could be done was to complete the plant a year later. The final price tag is about $1.42 billion, including ''allowance for funds used during construction''. In operation to date the post core loading test program has been completed in less than two months, enabling the plant to be put into commercial operation only two months after its original scheduled date of May 28, 1983exclamation

In vitro susceptibility to ST-246 and Cidofovir corroborates the phylogenetic separation of Brazilian Vaccinia virus into two clades.

Science.gov (United States)

Pires, Mariana A; Rodrigues, Nathália F S; de Oliveira, Danilo B; de Assis, Felipe L; Costa, Galileu B; Kroon, Erna G; Mota, Bruno E F

2018-04-01

The Orthopoxvirus (OPV) genus of the Poxviridae family contains several human pathogens, including Vaccinia virus (VACV), which have been implicating in outbreaks of a zoonotic disease called Bovine Vaccinia in Brazil. So far, no approved treatment exists for OPV infections, but ST-246 and Cidofovir (CDV) are now in clinical development. Therefore, the objective of this work was to evaluate the susceptibility of five strains of Brazilian VACV (Br-VACV) to ST-246 and Cidofovir. The susceptibility of these strains to both drugs was evaluated by plaque reduction assay, extracellular virus's quantification in the presence of ST-246 and one-step growth curve in cells treated with CDV. Besides that, the ORFs F13L and E9L were sequenced for searching of polymorphisms associated with drug resistance. The effective concentration of 50% (EC 50 ) from both drugs varies significantly for different strains (from 0.0054 to 0.051 μM for ST-246 and from 27.14 to 61.23 μM for CDV). ST-246 strongly inhibits the production of extracellular virus for all isolates in concentrations as low as 0.1 μM and it was observed a relevant decrease of progeny production for all Br-VACV after CDV treatment. Sequencing of the F13L and E9L ORFs showed that Br-VACV do not present the polymorphism(s) associated with resistance to ST-246 and CDV. Taken together, our results showed that ST-246 and CDV are effective against diverse, wild VACV strains and that the susceptibility of Br-VACV to these drugs mirrored the phylogenetic split of these isolates into two groups. Thus, both ST-246 and CDV are of great interest as compounds to treat individuals during Bovine Vaccinia outbreaks in Brazil. Copyright © 2018 Elsevier B.V. All rights reserved.

ORNL's NRC-sponsored HTGR safety and licensing analysis activities for Fort St. Vrain and advanced reactors

International Nuclear Information System (INIS)

Ball, S.J.; Cleveland, J.C.; Harrington, R.M.

1985-01-01

The ORNL safety analysis program for the HTGR was established in 1974 to provide technical assistance to the USNRC on licensing questions for both Fort St. Vrain and advanced plant concepts. The emphasis has been on development of major component and system dynamic simulation codes, and use of these codes to analyze specific licensing-related scenarios. The program has also emphasized code verification, using Fort St. Vrain data where applicable, and comparing results with industry-generated codes. By the use of model and parameter adjustment routines, safety-significant uncertainties have been identified. A major part of the analysis work has been done for the Fort St. Vrain HTGR, and has included analyses of FSAR accident scenario re-evaluations, the core block oscillation problem, core support thermal stress questions, technical specification upgrade review, and TMI action plan applicability studies. The large, 2240-MW(t) cogeneration lead plant design was analyzed in a multi-laboratory cooperative effort to estimate fission product source terms from postulated severe accidents

Projections of Climate Change over China for the 21st Century

Institute of Scientific and Technical Information of China (English)

LUO Yong; ZHAO Zongci; XU Ying; GAO Xuejie; DING Yihui

2005-01-01

The projections of climate changes in China for the 21st century by about 40 climate scenarios and multi-model ensembles have been investigated in this research. All the models with the different scenarios project a warming of 1.2℃ to 9.2℃ in China by the end of 21st century. Most of the projections point show the increasing of precipitation in China for the 21st century.

Molecular Characterization of Methicillin-Resistant Staphylococcus aureus from Outpatients in Northern Japan: Increasing Tendency of ST5/ST764 MRSA-IIa with Arginine Catabolic Mobile Element.

Science.gov (United States)

Aung, Meiji Soe; Kawaguchiya, Mitsuyo; Urushibara, Noriko; Sumi, Ayako; Ito, Masahiko; Kudo, Kenji; Morimoto, Shigeo; Hosoya, Shino; Kobayashi, Nobumichi

2017-07-01

Arginine catabolic mobile element (ACME) is a genomic island of staphylococcus and is considered to confer enhanced ability to survive and growth on host bacterial cells. ACME has been typically identified in Panton-Valentine Leukocidin (PVL)-positive ST8 methicillin-resistant Staphylococcus aureus (MRSA) with SCCmec type IVa (USA300 clone), and it is also found in other lineages at low frequency. Prevalence and molecular characteristics of PVL + and/or ACME + MRSA were investigated for 624 clinical isolates collected from outpatients in northern Japan from 2013 to 2014. Both PVL genes and ACME type I were detected in nine isolates (1.4%), which were ST8-MRSA-SCCmec IVa/spa type t008/agr-I; whereas solely PVL genes were positive in two isolates, ST30-MRSA-SCCmec IV and ST59-MRSA-SCCmec V. ACME type II' (previously referred to as ACME ΔII) was detected in 36 isolates (5.8%) with SCCmec II and V (32 and 4 isolates, respectively), exhibiting an increased rate within SCCmec II-MRSA (7.1%) compared with our previous studies (0.86-4.5%, 2008-2011). ACME II'-positive MRSA strains were classified into ST5-SCCmec IIa/V or ST764-SCCmec IIa belonging to five different spa types, with t002 being dominant. They harbored mostly enterotoxin gene clusters (seg-sei-sem-sen-seo-seu) and some more enterotoxin genes (seb1, seb2, sec3, sel, sep), showing resistance to more antimicrobials than ST8-MRSA-SCCmec IVa. ACME-SCCmec composite island (CI) of the 36 ACME II'-positive MRSA was classified into five types (ii)-(vi), among which type (ii) (orfX-ΨSCC ΔJ1 SCCmec I -ACME II'-SCCmec II) was dominant and subdivided into the A3 variant and the less common A2 variant. CI types (v) and (vi) were considered novel genetic organizations having speG (acetyltransferase genes for polyamines) in inserted SCC4610/SCC266-like genetic elements. The present study revealed increased prevalence and genetic diversity of the ST5/ST764-MRSA-SCCmec II with ACME II' in northern Japan.

21st centuries skill implication on educational system

Science.gov (United States)

Wrahatnolo, T.; Munoto

2018-01-01

The purpose of this article is to identify skill needed in 21st centuries and its implication on Indonesia’s educational system. This research found that the 21st centuries skill application has more measurable benefits in some sections of life, such as critical thinking and problem solving, initiative, creativity, and entrepreneurship, communication, teamwork, metacognition (change of mindset), digital literature. This study applied qualitative data analysis. The data were taken from different sources and literature. The analysis showed that The 21st centuries education concept’s implementation can be applied in the curriculum of the required subject that is addressed to achieve learning and innovation skills competence and also technology and information media skills competence. While supporting subject group directed to achieve life and career skills competence. All subjects are the derivation from core subject 3R, which are reading, writing, and arithmetic. Based on the description above, it can be concluded that 21st centuries skill needs; (1) a life planning; (2) flexibility and adaptability; (3) initiative and self-management (4) entrepreneurship; (5) social and cultural interaction; (6) productivity and accountability; (7) leadership; (8) critical thinking, (9) problem solving; (10) communication; (11) collaboration and teamwork; (12) lifelong learning; and (13) digital literation.

Anstrengelsesinduceret ST-segmentdepression efter akut myokardieinfarkt. Forekomst og prognostisk betydning

DEFF Research Database (Denmark)

Mickley, H; Pless, P; May, O

1989-01-01

On the basis of a review of 20 investigations (3,587 patients), the prevalence of significant ST-segment-depression (ST-depr) in patients performing an exercise test 9-30 days after acute myocardial infarction (AMI) was found to be 33% (3-70%). The reason for the considerable variation is due...... to a combination of several factors: 1) different and frequently incomplete definition of significant ST-depr; 2) heterogenically composed patient groups (first vs subsequent AMI, different prevalence of infarct types and localization, consecutive vs selected patients, +/- cardioactive drugs during the exercise...

Smartphones and Other Mobile Devices: The Swiss Army Knives of the 21st Century

Science.gov (United States)

Livingston, Alan

2004-01-01

MIAD stands for "mobile Internet access device." MIADs are the Swiss Army knives of the 21st century; they help users perform specific tasks in specific situations (including academic tasks in academic situations), thereby making users smarter and more productive. There are, however, significant obstacles to their effective use in higher…

Micro-instability physics as illuminated by the ST

International Nuclear Information System (INIS)

Roach, C. M.; Applegate, D. J.; Cowley, S. C.; Dorland, W. D.; Joiner, N.

2005-01-01

Spherical tokamaks (STs) have attractive features for fusion, and there is considerable interest in understanding their transport properties, which are likely to be determined by the underlying micro-instabilities. Inhomogeneity in the magnetic field and . effects are large in STs, and are known to have important influences on the particle dynamics and the nature of the underlying micro-instabilities respectively. Gyrokinetic micro stability calculations, using the flux-tube geometry code GS2, are presented for a number of ST equilibria, some closely resembling those from the MAST experiment. These calculations are performed both with and without electromagnetic effects (which are fully included in GS2). In a modest . MAST equilibrium, ion temperature gradient driven drift waves (ITG) are close to being stabilised by sheared equilibrium ... flows, but electron temperature gradient driven drift waves (ETG) have stronger growth rates and cannot usually be stabilised in this way. Electromagnetic effects, even in this relatively low . equilibrium, appear to give rise to longer perpendicular wavelength tearing parity modes in the plasma core [1]. Micro stability analyses are also presented for higher . equilibria, including that proposed for a conceptual ST power plant, where tearing parity modes are found over wide ranges of perpendicular length scales. Mixing length estimates from linear calculations may suggest the level of the transport coefficients, but nonlinear calculations are required to derive the heat and particle fluxes self-consistently. The status of these computations, which are particularly challenging in today's STs. will be reviewed, and the issues that must be resolved in the future in order to improve these calculations will be outlined. (Author)

ARIES-ST STUDIES REPORT FOR THE PERIOD JANUARY 1, 1998 THROUGH DECEMBER 31, 1998

International Nuclear Information System (INIS)

V.S. CHAN; L.L. LAO; Y.R. LIN-LIU; R.L. MILLER; T.W. PETRIE; P.A. POLITZER; R. PRATER; M.J. SCHAFFER; G.M. STAEBLER; R.D. STAMBAUGH; A.D. TURNBULL; W.P.WEST

1999-01-01

During 1998, the General Atomics (GA) ARIES-Spherical Torus (ST) team examined several critical issues related to the physics performance of the ARIES-ST design, and a number of suggestions were made concerning possible improvements in performance. These included specification of a reference plasma equilibrium, optimization about the reference equilibrium to achieve higher beta limits, examination of three possible schemes for plasma initiation, development of a detailed scenario for ramp-up of the plasma current and pressure to its full, final operating values, an assessment of the requirement for electron confinement, and several suggestions for divertor heat flux reduction. The reference equilibrium was generated using the TOQ code, with the specification of a 100%, self-consistent bootstrap current. The equilibrium has β = 51%, 10% below the stability limit (a margin specified by the ARIES-ST study). In addition, a series of intermediate equilibria were defined, corresponding to the ramp-up scenario discussed. A study of the influence of shaping on ARIES-ST performance indicates that significant improvement in both kink and ballooning stability can be obtained by modest changes in the squareness of the plasma. In test equilibria the ballooning beta limit is increased from 58% to 67%. Also the maximum allowable plasma-wall separation for kink stability can be increased by 30%. Three schemes were examined for noninductive plasma initiation. These are helicity injection (HICD), electron cyclotron heating (ECH)-assisted startup, and inductive startup using only the external equilibrium coils. HICD startup experiments have been done on the HIT and CDX devices. ECH-assisted startup has been demonstrated on CDX-U and DIII-D. External coil initiation is based on calculations for a proposed DIII-D experiment. In all cases, plasma initiation and preparation of an approximately 0.3 MA plasma for ARIES-ST appears entirely feasible

Early repolarization with horizontal ST segment may be associated with aborted sudden cardiac arrest: a retrospective case control study

Directory of Open Access Journals (Sweden)

Kim Sung

2012-12-01

Full Text Available Abstract Background Risk stratification of the early repolarization pattern (ERP is needed to identify malignant early repolarization. J-point elevation with a horizontal ST segment was recently suggested as a malignant feature of the ERP. In this study, the prevalence of the ERP with a horizontal ST segment was examined among survivors of sudden cardiac arrest (SCA without structural heart disease to evaluate the value of ST-segment morphology in risk stratification of the ERP. Methods We reviewed the data of 83 survivors of SCA who were admitted from August 2005 to August 2010. Among them, 25 subjects without structural heart disease were included. The control group comprised 60 healthy subjects who visited our health promotion center; all control subjects were matched for age, sex, and underlying disease (diabetes mellitus, hypertension. Early repolarization was defined as an elevation of the J point of at least 0.1 mV above the baseline in at least two continuous inferior or lateral leads that manifested as QRS slurring or notching. An ST-segment pattern of Results The SCA group included 17 men (64% with a mean age of 49.7 ± 14.5 years. The corrected QTc was not significantly different between the SCA and control groups (432.7 ± 37.96 vs. 420.4 ± 26.3, respectively; p = 0.089. The prevalence of ERP was not statistically different between the SCA and control groups (5/25, 20% vs. 4/60, 6.7%, respectively; p = 0.116. The prevalence of early repolarization with a horizontal ST segment was more frequent in the SCA than in the control group (20% vs. 3.3%, respectively; p = 0.021. Four SCA subjects (16% and one control subject (1.7% had a J-point elevation of >2 mm (p = 0.025. Four SCA subjects (16% and one (1.7% control subject had an ERP in the inferior lead (p = 0.025. Conclusion The prevalence of ERP with a horizontal ST segment was higher in patients with aborted SCA than in matched controls. This result suggests that ST morphology has

Characterization of staphylococci in urban wastewater treatment plants in Spain, with detection of methicillin resistant Staphylococcus aureus ST398.

Science.gov (United States)

Gómez, Paula; Lozano, Carmen; Benito, Daniel; Estepa, Vanesa; Tenorio, Carmen; Zarazaga, Myriam; Torres, Carmen

2016-05-01

The objective of this study was to determine the prevalence of Staphylococcus in urban wastewater treatment plants (UWTP) of La Rioja (Spain), and to characterize de obtained isolates. 16 wastewater samples (8 influent, 8 effluent) of six UWTPs were seeded on mannitol-salt-agar and oxacillin-resistance-screening-agar-base for staphylococci and methicillin-resistant Staphylococcus aureus recovery. Antimicrobial susceptibility profile was determined for 16 antibiotics and the presence of 35 antimicrobial resistance genes and 14 virulence genes by PCR. S. aureus was typed by spa, agr, and multilocus-sequence-typing, and the presence of immune-evasion-genes cluster was analyzed. Staphylococcus spp. were detected in 13 of 16 tested wastewater samples (81%), although the number of CFU/mL decreased after treatment. 40 staphylococci were recovered (1-5/sample), and 8 of them were identified as S. aureus being typed as (number of strains): spa-t011/agr-II/ST398 (1), spa-t002/agr-II/ST5 (2), spa-t3262/agr-II/ST5 (1), spa-t605/agr-II/ST126 (3), and spa-t878/agr-III/ST2849 (1). S. aureus ST398 strain was methicillin-resistant and showed a multidrug resistance phenotype. Virulence genes tst, etd, sea, sec, seg, sei, sem, sen, seo, and seu, were detected among S. aureus and only ST5 strains showed genes of immune evasion cluster. Thirty-two coagulase-negative Staphylococcus of 12 different species were recovered (number of strains): Staphylococcus equorum (7), Staphylococcus vitulinus (4), Staphylococcus lentus (4), Staphylococcus sciuri (4), Staphylococcus fleurettii (2), Staphylococcus haemolyticus (2), Staphylococcus hominis (2), Staphylococcus saprophyticus (2), Staphylococcus succinus (2), Staphylococcus capitis (1), Staphylococcus cohnii (1), and Staphylococcus epidermidis (1). Five presented a multidrug resistance phenotype. The following resistance and virulence genes were found: mecA, lnu(A), vga(A), tet(K), erm(C), msr(A)/(B), mph(C), tst, and sem. We found that

Orthophoto Mosaic (2012) of the St. Thomas East End Reserve

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This 0.3x0.3 meter imagery mosaic of the St. Thomas East End Reserve (STEER), St. Thomas in the U.S. Virgin Islands was created by the National Oceanic and...

Building a Stückelberg portal

Energy Technology Data Exchange (ETDEWEB)

Feng, Wan-Zhe [Center for Fundamental Physics and Institute for Advanced Study,Hong Kong University of Science and Technology (Hong Kong); Max-Planck-Institut für Physik (Werner-Heisenberg-Institut),80805 München (Germany); Shiu, Gary; Soler, Pablo; Ye, Fang [Center for Fundamental Physics and Institute for Advanced Study,Hong Kong University of Science and Technology (Hong Kong); Department of Physics, University of Wisconsin,Madison, WI 53706 (United States)

2014-05-15

We construct explicit string theory models realizing the recently proposed “Stückelberg Portal” scenario, a framework for building Z{sup ′} mediation models without the need to introduce unwanted exotic matter charged under the Standard Model. This scenario can be viewed purely field-theoretically, although it is particularly well motivated from string theory. By analyzing carefully the Stückelberg couplings between the Abelian gauge bosons and the RR axions, we construct the first global intersecting brane models which extend the Standard Model with a genuine hidden sector, to which it is nonetheless connected via U(1) mass mixings. Utilizing the explicit models we construct, we discuss some broad phenomenological properties and experimental implications of this scenario such as Z−Z{sup ′} mixings, dark matter stability and relic density, and supersymmetry mediation. With an appropriate confining hidden sector, our setup also provides a minimal realization of the hidden valley scenario. We further explore the possibility of obtaining small Z{sup ′} masses from a large ensemble of U(1) bosons. Related to the Stückelberg portal are two mechanisms that connect the visible and the hidden sectors, namely mediation by non-perturbative operators and the hidden photon scenario, on which we briefly comment.

Globalization, urbanization, and language in Caribbean development: the assimilation of St. Lucia

Directory of Open Access Journals (Sweden)

Aonghas St-Hilaire

2003-01-01

Full Text Available Discusses the trend toward Anglicization in St. Lucia, and the increasing demise of the Kwéyòl language in the historically Kweyol-speaking rural districts, related to perceived opportunities for economic advancement. Author explains how this influence of Anglicization spread from the, more English-focused, capital Castries to the rural areas of the islands. He places this perception of English for economic possibilities (of children, partly also fueled by US impact, alongside the gains of cultural nationalism including Kwéyòl promotion in the past 3 decades, such as increasing use of the language on the radio and festivals. Kwéyòl is also seen as a part of an St. Lucian identity. He points out how, nonetheless, the government or parents do not really invest in it, and favor knowledge of English among children.

AM-37 and ST-36 Are Small Molecule Bombesin Receptor Antagonists.

Science.gov (United States)

Moody, Terry W; Tashakkori, Nicole; Mantey, Samuel A; Moreno, Paola; Ramos-Alvarez, Irene; Leopoldo, Marcello; Jensen, Robert T

2017-01-01

While peptide antagonists for the gastrin-releasing peptide receptor (BB 2 R), neuromedin B receptor (BB 1 R), and bombesin (BB) receptor subtype-3 (BRS-3) exist, there is a need to develop non-peptide small molecule inhibitors for all three BBR. The BB agonist (BA)1 binds with high affinity to the BB 1 R, BB 2 R, and BRS-3. In this communication, small molecule BBR antagonists were evaluated using human lung cancer cells. AM-37 and ST-36 inhibited binding to human BB 1 R, BB 2 R, and BRS-3 with similar affinity ( K i = 1.4-10.8 µM). AM-13 and AM-14 were approximately an order of magnitude less potent than AM-37 and ST-36. The ability of BA1 to elevate cytosolic Ca 2+ in human lung cancer cells transfected with BB 1 R, BB 2 R, and BRS-3 was antagonized by AM-37 and ST-36. BA1 increased tyrosine phosphorylation of the EGFR and ERK in lung cancer cells, which was blocked by AM-37 and ST-36. AM-37 and ST-36 reduced the growth of lung cancer cells that have BBR. The results indicate that AM-37 and ST-36 function as small molecule BB receptor antagonists.

76 FR 77208 - Affirmation of Vertical Datum for Surveying and Mapping Activities for the Islands of St. Croix...

Science.gov (United States)

2011-12-12

... Datum for Surveying and Mapping Activities for the Islands of St. Croix, St. John, and St. Thomas... datum for surveying and mapping activities for the islands of St. Croix, St. John, and St. Thomas of the... by other Federal surveying and mapping agencies on St. Croix, St. John, and St. Thomas, with the...

Mode of action and in vitro susceptibility of mastitis pathogens to macedocin ST91KM and preparation of a teat seal containing the bacteriocin

Directory of Open Access Journals (Sweden)

Renee Pieterse

2010-03-01

Full Text Available Mastitis is considered to be the most economically costly disease affecting the dairy industry. Regular dosage of animals with antibiotics, including use of prophylactic concentrations, may select for resistant strains. The purpose of this study was to determine the mode of action of a new bacteriocin (macedocin ST91KM, to evaluate the antimicrobial resistance of mastitis pathogens to antibiotics commonly used in treatment remedies, and to introduce the possible use of an alternative antimicrobial agent. The bacteriocin macedocin ST91KM, produced by Streptococcus gallolyticus subsp. macedonicus ST91KM, is bactericidal to Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus uberis and Staphylococcus aureus associated with mastitis infections, including strains resistant to methicillin and oxacillin. Sensitive cells were deformed and secreted nucleotides, K+ and β-galactosidase when exposed to macedocin ST91KM. Adsorption of the peptide to target cells decreased in the presence of solvents, suggesting that receptors on the cell surfaces have lipid moieties. No adsorption was recorded in the presence of MgCl2, KI and Na2CO3, suggesting that ionic strength plays an important role. A teat seal preparation containing macedocin ST91KM effectively released the peptide and inhibited the growth of S. agalactiae. Macedocin ST91KM could form the basis for alternative dry cow therapy to prevent mastitis infections in dairy cows as it is effective against pathogens that display resistance to conventional antibiotic therapy.

Hemodialysis Infection Prevention Protocols Ontario—Shower Technique (HIPPO-ST: A Pilot Randomized Trial

Directory of Open Access Journals (Sweden)

S. Daisy Kosa

2017-03-01

Discussion: This HIPPO-ST pilot study demonstrated the feasibility of the larger HIPPO-ST study, especially given the high levels of education success with the HIPPO-ST arm and the low levels of contamination in the control arm.

The non-marine Mollusca of St. Martin (Lesser Antilles)

NARCIS (Netherlands)

Coomans, H.E.

1967-01-01

After our studies about the marine mollusks of St. Martin, (COOMANS 1963a, 1963b), this publication will deal with the land and freshwater shells of the island. The non-marine mollusks of St. Martin were already fairly well known at the end of the last century (MAZÉ 1890, p. 22—34), who mentioned 36

33 CFR 165.762 - Security Zone; St. Thomas, U.S. Virgin Islands.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone; St. Thomas, U.S....762 Security Zone; St. Thomas, U.S. Virgin Islands. (a) Location. Moving and fixed security zones are established 50 yards around all cruise ships entering, departing, moored or anchored in the Port of St. Thomas...

CRED 20 m Gridded bathymetry of Brooks Banks and St. Rogatien Bank, Hawaii, USA (Arc ASCII format)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Gridded bathymetry (20m) of the shelf and slope environments of Brooks Banks and St. Rogatien, Hawaii, USA. The ASCII includes multibeam bathymetry from the Simrad...

Axial Fatigue Tests at Zero Mean Stress of 24S-T and 75S-T Aluminum-alloy Strips with a Central Circular Hole

Science.gov (United States)

Brueggeman, W C; Mayer, M JR

1948-01-01

Axial fatigue tests at zero mean stress have been made on 0.032- and 0.064-inch 24S-T and 0.032-inch 75S-T sheet-metal specimens 1/4, 1/2, 1, and 2 inches wide without a hole and with central holes giving a range of hole diameter D to specimen width W from 0.01 to 0.95. No systematic difference was noted between the results for the 0.032-inch and the 0.064-inch specimens although the latter seemed the more consistent. In general the fatigue strength based on the minimum section dropped sharply as the ration D/W was increased from zero to about 0.25. The plain specimens showed quite a pronounced decrease in fatigue strength with increasing width. The holed specimens showed only slight and rather inconclusive evidence of this size effect. The fatigue stress-concentration factor was higher for 75S-T than for 24S-T alloy. Evidence was found that a very small hole would not cause any reduction in fatigue strength.

ST product characteristics and relationships with perceptions and behaviors among rural adolescent males: a qualitative study.

Science.gov (United States)

Couch, Elizabeth T; Darius, Ellen F; Walsh, Margaret M; Chaffee, Benjamin W

2017-12-01

Although smoking declines in the United States, the prevalence of male adolescent smokeless tobacco (ST; moist snuff and chewing tobacco) use remains unchanged. ST product characteristics, such as flavoring, packaging, and branding, could influence adolescents' ST initiation and continued use. This qualitative study examines the potential role of product characteristics in shaping ST-related perceptions and behaviors among rural adolescent males. Semi-structured individual interviews were conducted at three California rural high schools. ST users were asked about their experiences and perceptions related to product characteristics. Interviews were transcribed, coded, and analyzed using a general inductive approach. Participants associated flavored ST with appealing non-tobacco products, such as chewing gum and alcohol. Availability of different varieties and flavors stimulated interest and curiosity in sampling or switching between ST products. Time-limited promotional flavors and packaging also enhanced product appeal. Adolescent ST users preferred certain brands based on perceived brand features and perceived nicotine content, associating higher-strength brands as better suited for experienced ST users. Brand preferences frequently reflected perceived ST brand popularity within peer groups. Based on these observations, potential ST regulation and health education campaigns to address misconceptions about ST characteristics could influence adolescents' ST-related perceptions and reduce ST use among this vulnerable population. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Minor Electrocardiographic ST-T Change and Risk of Stroke in the General Japanese Population.

Science.gov (United States)

Ishikawa, Joji; Hirose, Hideo; Schwartz, Joseph E; Ishikawa, Shizukiyo

2018-06-25

Minor ST-T changes are frequently observed on the electrocardiogram (ECG), but the risk of stroke associated with such changes is unclear.Methods and Results:In 10,642 subjects from the Japanese general population, we evaluated minor and major ST-T changes (major ST depression ≥0.1 mV) on ECGs obtained at annual health examinations. At baseline, minor ST-T changes were found in 10.7% of the subjects and 0.5% had major ST-T changes. Minor ST-T changes were associated with older age, female gender, higher systolic blood pressure, presence of hyperlipidemia, and use of antihypertensive medication. There were 375 stroke events during the follow-up period (128.7±28.1 months). In all subjects, minor ST-T changes (HR, 2.10; 95% CI: 1.57-2.81) and major ST-T changes (HR, 8.64; 95% CI: 4.44-16.82) were associated with an increased risk of stroke, but the stroke risk associated with minor ST-T changes had borderline significance after adjustment for conventional risk factors (P=0.055). In subgroup analysis, the risk of stroke was significantly associated with minor ST-T changes in subjects who had hyperlipidemia (HR, 1.75; 95% CI: 1.15-2.67) compared to those without hyperlipidemia (HR, 1.01; 95% CI: 0.64-1.59; P for interaction=0.016), even after adjustment for ECG-diagnosed left ventricular hypertrophy. Minor ST-T changes were particularly associated with a higher risk of stroke in subjects with hyperlipidemia and this association was independent of electrocardiographic left ventricular hypertrophy.

Comparative genomics and drug resistance of a geographic variant of ST239 methicillin-resistant Staphylococcus aureus emerged in Russia.

Directory of Open Access Journals (Sweden)

Tatsuo Yamamoto

Full Text Available Two distinct classes of methicillin-resistant Staphylococcus aureus (MRSA are spreading in hospitals (as hospital-acquired MRSA, HA-MRSA and in the community (as community-acquired MRSA, CA-MRSA. Multilocus sequence type (ST 239 MRSA, one of the most worldwide-disseminated lineages, has been noted as a representative HA-MRSA. Here, we isolated ST239 MRSA (spa type 3 [t037] and staphylococcal cassette chromosome mec [SCCmec] type III.1.1.1 and its novel variant with ST239/spa351 (t030/SCCmecIII.1.1.4 (SCCmecIII(R not only from hospitals but also from patients with urethritis in the community in Russia. The Russian variant (strain 16K possessed a hybrid genome consisting of CC8 and CC30, similar to the ST239/spa3/SCCmecIII.1.1.1 HA-MRSA (TW20 genome, but with marked diversity. The 16K' CC30 section had SCCmecIII(R carrying the dcs-carrying unit (which corresponded to the SCCmecIVc J3 joining region of ST30 CA-MRSA, lacked SCCmercury, and possessed a novel mobile element structure (MES16K carrying the ccrC-carrying unit (with the recombinase gene ccrC1 allele 3 and drug resistance tranposons. The Russian variant included strains with a high ability to transfer its multiple drug resistance by conjugation; e.g., for strain 16K, the transfer frequency of a chloramphenicol resistance plasmid (p16K-1 with 2.9 kb in size reached 1.4×10(-2, followed by Tn554 conjugative transfer at 3.6×l0(-4. The Russian variant, which has been increasing recently, included divergent strains with different plasmid patterns and pulsed field gel electrophoresis profiles. The data demonstrate the alternative nature of ST239 MRSA as CA-MRSA and also as a drug resistance disseminator, and its micro but dynamic evolution in Russia.

Topical application of ST266 reduces UV-induced skin damage

Directory of Open Access Journals (Sweden)

Guan L

2017-11-01

Full Text Available Linna Guan,1 Amanda Suggs,1 Emily Galan,1 Minh Lam,1 Elma D Baron1,2 1Department of Dermatology, Case Western Reserve University, 2Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA Abstract: Ultraviolet radiation (UVR has a significant impact on human skin and is the major environmental factor for skin cancer formation. It is also believed that 80% of the signs of skin aging are attributed to UVR. UVR induces inflammatory changes in the skin via the increase in oxidative stress, DNA damage vascular permeability, and fluctuation in a myriad of cytokines. Acutely, UVR causes skin inflammation and DNA damage, which manifest as sunburn (erythema. ST266 is the secretome of proprietary amnion-derived cells that have been shown to reduce inflammation and accelerate healing of various wounds by promoting migration of keratinocytes and fibroblasts in preclinical animal studies. We hypothesized that ST266 has anti-inflammatory effects that can be used to reduce ultraviolet (UV erythema and markers of inflammation. In this study, we examined the in vivo effects of ST266 on post UV-irradiated skin by measuring erythema, level of cyclobutane pyrimidine dimer (CPD, and expression level of xeroderma pigmentosum, complementation group A (XPA. We demonstrated that ST266 has the potential to reduce the acute effects of UV-induced skin damage when applied immediately after the initial exposure. In addition, ST266 is shown to reduce erythema, increase XPA DNA repair protein, and decrease damaged DNA. Keywords: ST266, photoaging, erythema, CPD, XPA, UV-induced DNA damage

Dominance of multidrug-resistant Denmark(14)-32 (ST230) clone among Streptococcus pneumoniae serotype 19A isolates causing pneumococcal disease in Bulgaria from 1992 to 2013.

Science.gov (United States)

Setchanova, Lena Petrova; Alexandrova, Alexandra; Dacheva, Daniela; Mitov, Ivan; Kaneva, Radka; Mitev, Vanio

2015-02-01

A pneumococcal conjugate vaccine (PCV10) was introduced in Bulgarian national immunization program since April 2010. Clonal composition based on pulsed-field gel electrophoresis and multilocus sequence typing genotyping of 52 serotype 19A Streptococcus pneumoniae isolates was analyzed. These were invasive and respiratory isolates collected between 1992 and 2013 from both children (78.8% clone. The most frequent sequence type (ST) was ST230 (48.1%) and together with four other closely related STs (15.4%), belonging to ST1611, ST276, ST7466, and ST2013, which were single- and double-locus variants; they were included in the main CC230. The disappearance of highly drug-resistant ST663 clone and emergence of new clones as CC320 and CC199 was also observed among the rest 19A isolates. A comparison of clonal composition between invasive and noninvasive isolates did not show a great genetic diversity among both kinds of isolates. Continuous surveillance of serotype 19A population following the introduction of PCV10 is essential to evaluate the impact of the vaccine on the epidemiology of this serotype.

Reliability and Validity of Michigan School Libraries for the 21st Century Measurement Benchmarks

Science.gov (United States)

Floyd, Natosha N.

2016-01-01

The purpose of this study was to examine the psychometric properties of the Michigan School Libraries for the 21st Century Measurement Benchmarks (SL21). The instrument consists of 19 items with three subscales: Building the 21st Century Learning Environment Subscale, Teaching for 21st Century Learning Subscale, and Leading the Way to 21st Century…

Identification of a novel clone, ST736, among Enterococcus faecium clinical isolates and its association with daptomycin nonsusceptibility.

Science.gov (United States)

Wang, Guiqing; Kamalakaran, Sitharthan; Dhand, Abhay; Huang, Weihua; Ojaimi, Caroline; Zhuge, Jian; Yee, Leslie Lee; Mayigowda, Pramod; Surendraiah, Pavan Kumar Makam; Dimitrova, Nevenka; Fallon, John T

2014-08-01

Resistance to daptomycin in enterococcal clinical isolates remains rare but is being increasingly reported in the United States and worldwide. There are limited data on the genetic relatedness and microbiological and clinical characteristics of daptomycin-nonsusceptible enterococcal clinical isolates. In this study, we assessed the population genetics of daptomycin-nonsusceptible Enterococcus faecium (DNSE) clinical isolates by multilocus sequence typing (MLST) and whole-genome sequencing analysis. Forty-two nonduplicate DNSE isolates and 43 randomly selected daptomycin-susceptible E. faecium isolates were included in the analysis. All E. faecium isolates were recovered from patients at a tertiary care medical center in suburban New York City from May 2009 through December 2013. The daptomycin MICs of the DNSE isolates ranged from 6 to >256 μg/ml. Three major clones of E. faecium (ST18, ST412, and ST736) were identified among these clinical isolates by MLST and whole-genome sequence-based analysis. A newly recognized clone, ST736, was seen in 32 of 42 (76.2%) DNSE isolates and in only 14 of 43 (32.6%) daptomycin-susceptible E. faecium isolates (P clone ST736 and daptomycin nonsusceptibility. The identification and potential spread of this novel E. faecium clone and its association with daptomycin nonsusceptibility constitute a challenge for patient management and infection control at our medical center. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Operational testing highlights of Fort St. Vrain

International Nuclear Information System (INIS)

Cadwell, J.J.; McEachern, D.W.; Read, J.W.; Simon, W.A.; Walker, R.F.

1975-01-01

The Fort St. Vrain program has progressed through construction, preoperational testing, fuel loading, initial criticality, and operational testing at power levels up to 2 percent related power. To date, all tests necessary before the rise to full power have been completed, and the rise-to-power program is expected to be resumed again in late 1975. Major plant systems, including the prestressed concrete reactor vessel and circulators, have demonstrated adequate performance. Extensive tests on the reactor core at zero power and up to 2 percent power have demonstrated the accuracy in the design predictions of such core characteristics as critical rod position, control system worths, neutron flux distributions, and temperature coefficients. Gaseous fission product release measurements to date have confirmed the extensive analytical estimates. 6 references

75 FR 32813 - St. Croix Chippewa Indians of Wisconsin Alcoholic Beverage Control Ordinance

Science.gov (United States)

2010-06-09

... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs St. Croix Chippewa Indians of Wisconsin...: This notice publishes the Secretary's certification of the amended St. Croix Chippewa Indians of... Country. The St. Croix Tribal Council of the adopted this amended Liquor Ordinance on December 3, 2009...

75 FR 21243 - Marine Mammals; Subsistence Taking of Northern Fur Seals; St. George

Science.gov (United States)

2010-04-23

... Mammals; Subsistence Taking of Northern Fur Seals; St. George AGENCY: National Marine Fisheries Service... (APA). The Pribilof Island Community of St. George Island, Traditional Council (Council) petitioned... St. George Island to take male fur seal young of the year during the fall. NMFS solicits public...

AM-37 and ST-36 Are Small Molecule Bombesin Receptor Antagonists

Directory of Open Access Journals (Sweden)

Terry W. Moody

2017-07-01

Full Text Available While peptide antagonists for the gastrin-releasing peptide receptor (BB2R, neuromedin B receptor (BB1R, and bombesin (BB receptor subtype-3 (BRS-3 exist, there is a need to develop non-peptide small molecule inhibitors for all three BBR. The BB agonist (BA1 binds with high affinity to the BB1R, BB2R, and BRS-3. In this communication, small molecule BBR antagonists were evaluated using human lung cancer cells. AM-37 and ST-36 inhibited binding to human BB1R, BB2R, and BRS-3 with similar affinity (Ki = 1.4–10.8 µM. AM-13 and AM-14 were approximately an order of magnitude less potent than AM-37 and ST-36. The ability of BA1 to elevate cytosolic Ca2+ in human lung cancer cells transfected with BB1R, BB2R, and BRS-3 was antagonized by AM-37 and ST-36. BA1 increased tyrosine phosphorylation of the EGFR and ERK in lung cancer cells, which was blocked by AM-37 and ST-36. AM-37 and ST-36 reduced the growth of lung cancer cells that have BBR. The results indicate that AM-37 and ST-36 function as small molecule BB receptor antagonists.

AM-37 and ST-36 Are Small Molecule Bombesin Receptor Antagonists

Science.gov (United States)

Moody, Terry W.; Tashakkori, Nicole; Mantey, Samuel A.; Moreno, Paola; Ramos-Alvarez, Irene; Leopoldo, Marcello; Jensen, Robert T.

2017-01-01

While peptide antagonists for the gastrin-releasing peptide receptor (BB2R), neuromedin B receptor (BB1R), and bombesin (BB) receptor subtype-3 (BRS-3) exist, there is a need to develop non-peptide small molecule inhibitors for all three BBR. The BB agonist (BA)1 binds with high affinity to the BB1R, BB2R, and BRS-3. In this communication, small molecule BBR antagonists were evaluated using human lung cancer cells. AM-37 and ST-36 inhibited binding to human BB1R, BB2R, and BRS-3 with similar affinity (Ki = 1.4–10.8 µM). AM-13 and AM-14 were approximately an order of magnitude less potent than AM-37 and ST-36. The ability of BA1 to elevate cytosolic Ca2+ in human lung cancer cells transfected with BB1R, BB2R, and BRS-3 was antagonized by AM-37 and ST-36. BA1 increased tyrosine phosphorylation of the EGFR and ERK in lung cancer cells, which was blocked by AM-37 and ST-36. AM-37 and ST-36 reduced the growth of lung cancer cells that have BBR. The results indicate that AM-37 and ST-36 function as small molecule BB receptor antagonists. PMID:28785244

The Gadaba and the "non-ST" Desia of Koraput, Orissa

NARCIS (Netherlands)

Berger, P.; Pfeffer, G.; Dehera, D.K.

2002-01-01

ABSTRACT: "Tribal studies" in Orissa (India) mainly focus on that part of the indigenous population of the hills, which is defined as " Scheduled Tribe" ("ST") by the administration. The southern-most Koraput District is no exception to that custom and the "non-ST" population of the region,

Proceedings of the 21st DOE/NRC nuclear air cleaning conference

International Nuclear Information System (INIS)

First, M.W.

1991-02-01

The 21st meeting of the Department of Energy/Nuclear Regulatory Commission (DOE/NRC) Nuclear Air Cleaning Conference was held in San Diego, CA on August 13--16, 1990. The proceedings have been published as a two volume set. Volume 2 contains sessions covering adsorbents, nuclear codes and standards, modelling, filters, safety, containment venting and a review of nuclear air cleaning programs around the world. Also included is the list of attendees and an index of authors and speakers

Gravity, Magnetic and Electromagnetic Gradiometry; Strategic technologies in the 21st century

Science.gov (United States)

Veryaskin, Alexey V.

2018-02-01

Gradiometry is a multidisciplinary area that combines theoretical and applied physics, ultra-low noise electronics, precision engineering, and advanced signal processing. Applications include the search for oil, gas, and mineral resources, GPS-free navigation, defence, space missions, and medical research. This book provides readers with a comprehensive introduction, history, potential applications, and current developments in relation to some of the most advanced technologies in the 21st Century.

Tritium stripping in a nitrogen glovebox using SAES St 198

International Nuclear Information System (INIS)

Klein, J.E.; Wermer, J.R.

1994-01-01

SAES metal getter material St 198 was chosen for glovebox stripper tests to evaluate its effectiveness of removing tritium from a nitrogen atmosphere. The St 198 material is unique from a number of other metal hydride-based getter materials in that it is relatively inert to nitrogen and can thus be used in nitrogen glovebox atmospheres. Six tritium stripper experiments which mock-up the use of a SAES St 198 stripper bed for a full-scale (10,500 liter) nitrogen glovebox have been completed. Experiments consisted of a release of small quantity of protium/deuterium spiked with tritium which were scaled to simulate tritium releases of 0.1 g., 1.0 g., and 10 g. into the glovebox. The tritium spike allows detection using tritium ion chambers. The St 198 stripper system produced a reduction in tritium activity of approximately two orders of magnitude in 24 hours (6--8 atmosphere turn-overs) of stripper operation

File list: His.Lar.05.AllAg.1st_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.Lar.05.AllAg.1st_instar dm3 Histone Larvae 1st instar SRX013088,SRX013009,SRX01...3064,SRX013044,SRX013097 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/His.Lar.05.AllAg.1st_instar.bed ...

File list: His.Lar.20.AllAg.1st_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.Lar.20.AllAg.1st_instar dm3 Histone Larvae 1st instar SRX013009,SRX013088,SRX01...3044,SRX013064,SRX013097 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/His.Lar.20.AllAg.1st_instar.bed ...

File list: His.Lar.50.AllAg.1st_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.Lar.50.AllAg.1st_instar dm3 Histone Larvae 1st instar SRX013009,SRX013088,SRX01...3044,SRX013064,SRX013097 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/His.Lar.50.AllAg.1st_instar.bed ...

File list: His.Lar.10.AllAg.1st_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.Lar.10.AllAg.1st_instar dm3 Histone Larvae 1st instar SRX013088,SRX013064,SRX01...3044,SRX013009,SRX013097 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/His.Lar.10.AllAg.1st_instar.bed ...

76 FR 38357 - Reorganization of Foreign-Trade Zone 102, Under Alternative Site Framework; St. Louis, MO

Science.gov (United States)

2011-06-30

... Zone 102, Under Alternative Site Framework; St. Louis, MO Pursuant to its authority under the Foreign.../2010) as an option for the establishment or reorganization of general-purpose zones; Whereas, the St... the City of St. Louis and St. Louis County, Missouri, within and adjacent to the St. Louis Customs and...

IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy.

Science.gov (United States)

Liu, Boyi; Tai, Yan; Achanta, Satyanarayana; Kaelberer, Melanie M; Caceres, Ana I; Shao, Xiaomei; Fang, Jianqiao; Jordt, Sven-Eric

2016-11-22

Poison ivy-induced allergic contact dermatitis (ACD) is the most common environmental allergic condition in the United States. Case numbers of poison ivy ACD are increasing due to growing biomass and geographical expansion of poison ivy and increasing content of the allergen, urushiol, likely attributable to rising atmospheric CO 2 Severe and treatment-resistant itch is the major complaint of affected patients. However, because of limited clinical data and poorly characterized models, the pruritic mechanisms in poison ivy ACD remain unknown. Here, we aim to identify the mechanisms of itch in a mouse model of poison ivy ACD by transcriptomics, neuronal imaging, and behavioral analysis. Using transcriptome microarray analysis, we identified IL-33 as a key cytokine up-regulated in the inflamed skin of urushiol-challenged mice. We further found that the IL-33 receptor, ST2, is expressed in small to medium-sized dorsal root ganglion (DRG) neurons, including neurons that innervate the skin. IL-33 induces Ca 2+ influx into a subset of DRG neurons through neuronal ST2. Neutralizing antibodies against IL-33 or ST2 reduced scratching behavior and skin inflammation in urushiol-challenged mice. Injection of IL-33 into urushiol-challenged skin rapidly exacerbated itch-related scratching via ST2, in a histamine-independent manner. Targeted silencing of neuronal ST2 expression by intrathecal ST2 siRNA delivery significantly attenuated pruritic responses caused by urushiol-induced ACD. These results indicate that IL-33/ST2 signaling is functionally present in primary sensory neurons and contributes to pruritus in poison ivy ACD. Blocking IL-33/ST2 signaling may represent a therapeutic approach to ameliorate itch and skin inflammation related to poison ivy ACD.

The Lesser Antillean Iguana (Iguana delicatissima) on St. Eustatius: genetically depauperate and threatened by ongoing hybridization.

Science.gov (United States)

van den Burg, Matthijs P; Meirmans, Patrick G; Wagensveld, Tim van; Kluskens, Bart; Madden, Hannah; Welch, Mark E; Breeuwer, Johannes A J

2018-02-19

The Lesser Antillean Iguana (Iguana delicatissima) is an endangered species threatened by habitat loss and hybridization with non-native Green Iguanas (Iguana iguana). Iguanadelicatissima has been extirpated on several islands, and the Green Iguana has invaded most islands with extant populations. Information is essential to protect this species from extinction. We collected data on 293 iguanas including 17 juveniles from St. Eustasius, one of the few remaining I. delicatissima strongholds. Genetic data was leveraged to test for hybridization presence with the Green Iguana using both mitochondrial and nuclear genes, including 16 microsatellite loci. The microsatellites were also analysed to estimate genetic diversity, population structure and effective population size. Using molecular and morphological data we identified 286 I. delicatissima individuals captured during our first fieldwork effort, and seven non-native iguanas captured during a second effort, showing hybridization occurs within this population. Comparing homologous microsatellites used in studies on Dominica and Chancel, the I. delicatissima population on St. Eustatius has extremely low genetic diversity (HO=0.051; HE=0.057), suggesting this population is genetically depauperate. Furthermore, there is significant evidence for inbreeding (FIS=0.12) and weak spatial genetic structure (FST=0.021, p=0.002) within this population. Besides immediate threats including hybridization, this population's low genetic diversity, presence of physiological abnormalities and low recruitment could indicate presence of inbreeding depression that threatens its long-term survival. We conclude there is a continued region-wide threat to I. delicatissima and highlight the need for immediate conservation action to stop the continuing spread of Green Iguanas and to eliminate hybridization from St. Eustatius.

Pre-hospital ticagrelor in ST-segment elevation myocardial infarction in the French ATLANTIC population

DEFF Research Database (Denmark)

Cayla, Guillaume; Lapostolle, Frederic; Ecollan, Patrick

2017-01-01

BACKGROUND: ATLANTIC was a randomized study comparing pre- and in-hospital treatment with a ticagrelor loading dose (LD) in ongoing ST-segment elevation myocardial infarction (STEMI). We sought to compare patient characteristics and clinical outcomes in France with other countries participating...... in ATLANTIC. METHODS: The population comprised 1862 patients, 660 (35.4%) from France and 1202 from 12 other countries. The main endpoints were reperfusion (≥70% ST-segment elevation resolution) and TIMI flow grade 3 before (co-primary endpoints) and after percutaneous coronary intervention (PCI). Other...... endpoints included a composite ischaemic endpoint (death/myocardial infarction/stroke/urgent revascularization/definite stent thrombosis) and bleeding events at 30days. RESULTS: In France, median times from first LD to angiography and between first and second LDs were 49 and 35min, respectively, and were...

Mount St. Helens aerosol evolution

Energy Technology Data Exchange (ETDEWEB)

Oberbeck, V.R.; Farlow, N.H.

1982-08-01

Stratospheric aerosol samples were collected using a wire impactor during the year following the eruption of Mount St. Helens. Analysis of samples shows that aerosol volume increased for 6 months due to gas-to-particle conversion and then decreased to background levels in the following 6 months.

Mount St. Helens aerosol evolution

Energy Technology Data Exchange (ETDEWEB)

Oberbeck, V.R.; Farlow, N.H.; Fong, W.; Snetsinger, K.G.; Ferry, G.V.; Hayes, D.M.

1982-09-01

Stratospheric aerosol samples were collected using a wire impactor during the year following the eruption of Mt. St. Helens. Analysis of samples show that aerosol volume increased for 6 months due to gas-to-particle conversion and then decreased to background levels in the following 6 months.

Interleukin-33 Receptor (ST2 Deficiency Improves the Outcome of Staphylococcus aureus-Induced Septic Arthritis

Directory of Open Access Journals (Sweden)

Larissa Staurengo-Ferrari

2018-05-01

Full Text Available The ST2 receptor is a member of the Toll/IL-1R superfamily and interleukin-33 (IL-33 is its agonist. Recently, it has been demonstrated that IL-33/ST2 axis plays key roles in inflammation and immune mediated diseases. Here, we investigated the effect of ST2 deficiency in Staphylococcus aureus-induced septic arthritis physiopathology. Synovial fluid samples from septic arthritis and osteoarthritis individuals were assessed regarding IL-33 and soluble (s ST2 levels. The IL-33 levels in samples from synovial fluid were significantly increased, whereas no sST2 levels were detected in patients with septic arthritis when compared with osteoarthritis individuals. The intra-articular injection of 1 × 107 colony-forming unity/10 μl of S. aureus American Type Culture Collection 6538 in wild-type (WT mice induced IL-33 and sST2 production with a profile resembling the observation in the synovial fluid of septic arthritis patients. Data using WT, and ST2 deficient (−/− and interferon-γ (IFN-γ−/− mice showed that ST2 deficiency shifts the immune balance toward a type 1 immune response that contributes to eliminating the infection due to enhanced microbicide effect via NO production by neutrophils and macrophages. In fact, the treatment of ST2−/− bone marrow-derived macrophage cells with anti-IFN-γ abrogates the beneficial phenotype in the absence of ST2, which confirms that ST2 deficiency leads to IFN-γ expression and boosts the bacterial killing activity of macrophages against S. aureus. In agreement, WT cells achieved similar immune response to ST2 deficiency by IFN-γ treatment. The present results unveil a previously unrecognized beneficial effect of ST2 deficiency in S. aureus-induced septic arthritis.

Expression of interleukin-33 and its receptor ST2 in periapical granulomas and radicular cysts.

Science.gov (United States)

Velickovic, Milena; Pejnovic, Nada; Petrovic, Renata; Mitrovic, Slobodanka; Jeftic, Ilija; Kanjevac, Tatjana; Lukic, Aleksandra

2016-01-01

Interleukin-33 (IL-33) is a recently identified cytokine belonging to the IL-1 family and ligand for the IL-1 receptor-related protein ST2. IL-33/ST2 signaling plays a critical role in allergy, autoimmunity, and chronic inflammatory disorders, but its role in the pathogenesis of periapical lesions is unknown. We aimed to investigate the expression patterns of IL-33 and ST2 in human periapical lesions. Periapical lesions (n = 36) and healthy periapical tissues (n = 10) were evaluated by immunohistochemistry using antibodies specific for human IL-33 and ST2. Lesion samples were further analyzed by double immunofluorescence to assess IL-33/ST2 co-expression. The numbers of IL-33- and ST2-positive fibroblasts were significantly higher in periapical lesions compared to healthy periapical tissues (both P 0.05). There were no significant differences in the numbers of IL-33- and ST2-positive fibroblasts and endothelial cells between periapical granulomas and radicular cysts (all P > 0.05). Similarly, numbers of ST2-positive mononuclear cells did not differ between periapical granulomas and radicular cysts (P > 0.05). The majority of epithelial cells in radicular cysts were IL-33 positive, while the small proportion of epithelial cells was ST2 positive. Double immunofluorescence analysis revealed IL-33/ST2 co-expression in fibroblasts and endothelial cells. IL-33 and ST2 are expressed in periapical granulomas and radicular cysts. Increased numbers of IL-33- and ST2-positive fibroblasts in periapical lesions when compared to healthy periapical tissues suggest that IL-33/ST2 signaling may be involved in periapical inflammation and tissue fibrosis. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

77 FR 32391 - Building a 21st Century Digital Government

Science.gov (United States)

2012-06-01

... of May 23, 2012 Building a 21st Century Digital Government Memorandum for the Heads of Executive... century digital Government that delivers better digital services to the American people. Today, the CIO is releasing that strategy, entitled ``Digital Government: Building a 21st Century Platform to Better Serve the...

New concept of siting in the 21st century

International Nuclear Information System (INIS)

Nakayama, Katsuma; Otsubo, Fumiharu; Kumagai, Shigeru

1995-01-01

The New Concept of Siting in the 21st Century -- the theme of this paper -- is the concept of a new siting technology which combines the application of man - made islands (offshore), underground (steep mountains along the sea), and quaternary ground with the symbiosis with local communities. It is intended not only for promotion of the construction of nuclear power plants but also for the development of a 'new community', including the inducement of enterprises to the construction site and the promotion of new industries at the site. In studying the new concept, it is necessary to select model areas, discuss design and construction methods, and make a rough calculation of construction cost. In addition, we plan to estimate economic effects of the new concept on the construction site area. During 1993, we discussed appropriate physical conditions (topographic feature, geological structure, etc.) and geographical conditions (population density, national parks, fishing right, etc.) for the application of the siting technology giving consideration to the concept symbiosis with local communities. At present, the estimations of construction cost and future effects of new siting technology on local communities are carried on to study the new concept of siting in the 21st century. (author)

Army Research Laboratory S&T Campaign Plans 2015-2035

Science.gov (United States)

2014-09-01

for micro-robotics, and high quality factor communications, electronic warfare. Efforts focus on the maturation of LEAD zirconium titanate ( PZT ) and...spectrums (multiple impact, high energy impact, and high to low cycle fatigue ) to meet the needs of current and future Army platforms and structures...MATERIALS RESEARCH CAMPAIGN’s Polymer Coatings S&T Footprint S&T AREA POSTURE Polymer Coatings LEAD Corrosion & Fatigue research explores corrosion

Audiovisuaalinen koulutuspaketti ensihoitohenkilöstölle peruselintoimintojen mittaamisesta

OpenAIRE

Pelkonen, Juha

2013-01-01

Tiivistelmä Tämä opinnäyteyö oli kehittämistyö, jonka tarkoituksena oli laatia audiovisuaalinen koulutuspaketti peruselintoimintojen mittaamisesta Pohjois-Savon pelastuslaitokselle ensihoitohenkilöstölle. Kehittämistyön tavoitteena oli vahvistaa pelastuslaitoksen ensihoitohenkilöstön osaamista peruselintoimintojen mittaamisessa. Koulutuspaketin tavoitteena oli antaa vaihtoehtoinen tapa kerrata jo vanhaa opittua sekä motivoida uuteen oppimiseen audiovisuaalisesti demonstraati...

Construction: first of St. Lucie unit 2 successes

International Nuclear Information System (INIS)

Conway, W.F.

1989-01-01

The Nuclear Regulatory Commission (NRC) granted a full power operating license for St. Lucie Unit 2 on June 10, 1983, just six years after construction began. The industry average for nuclear power plant construction during this time was approximately ten years. The rate of completion had a positive effect on the cost of the facility. The price of the unit was $1.42 billion as compared to the $2 billion to $5 billion range experienced by other utilities for nuclear plants. These accomplishments were not serendipitous but the results of management techniques and personnel attitudes involved in the construction of the unit. More importantly, many of these same techniques and attitudes have now become part of a quality improvement program at St Lucie and are reflected in its performance indicators. This paper analyzes the construction success of St Lucie Unit 2 and demonstrates that excellent performance in the construction phase can be carried over to the operation of a facility

Advanced ST plasma scenario simulations for NSTX

International Nuclear Information System (INIS)

Kessel, C.E.; Synakowski, E.J.; Gates, D.A.; Kaye, S.M.; Menard, J.; Phillips, C.K.; Taylor, G.; Wilson, R.; Harvey, R.W.; Mau, T.K.

2005-01-01

Integrated scenario simulations are done for NSTX that address four primary milestones for developing advanced ST configurations: high β and high β N inductive discharges to study all aspects of ST physics in the high beta regime; non-inductively sustained discharges for flattop times greater than the skin time to study the various current drive techniques; non-inductively sustained discharges at high βfor flattop times much greater than a skin time which provides the integrated advanced ST target for NSTX; and non-solenoidal startup and plasma current rampup. The simulations done here use the Tokamak Simulation Code (TSC) and are based on a discharge 109070. TRANSP analysis of the discharge provided the thermal diffusivities for electrons and ions, the neutral beam (NB) deposition profile and other characteristics. CURRAY is used to calculate the High Harmonic Fast Wave (HHFW) heating depositions and current drive. GENRAY/CQL3D is used to establish the heating and CD deposition profiles for electron Bernstein waves (EBW). Analysis of the ideal MHD stability is done with JSOLVER, BALMSC, and PEST2. The simulations indicate that the integrated advanced ST plasma is reachable, obtaining stable plasmas with β ∼ 40% at β N 's of 7.7-9, I P = 1.0 MA and B T = 0.35 T. The plasma is 100% non-inductive and has a flattop of 4 skin times. The resulting global energy confinement corresponds to a multiplier of H 98(y,2 ) = 1.5. The simulations have demonstrated the importance of HHFW heating and CD, EBW off-axis CD, strong plasma shaping, density control, and early heating/H-mode transition for producing and optimizing these plasma configurations (author)

National Dam Safety Program. Eaton Dam (MO 31163), Mississippi - Kaskaskia - St. Louis Basin, St. Francois County, Missouri. Phase I Inspection Report.

Science.gov (United States)

1981-04-01

located near the north end of the Simms Mountain Fault System. The site is actually within this system which is about 5 mi wide and 40 mi long, in a...oLegon I V Roubidoux Formation u aleA "Z.Gasconade Dolomite Gunter Sandstone Member Of Eminence Dolomite m~neY, jrk-Potosi Dolomite Derby-Doerufl...westnMsoui Vow" Lamotte Sandstone Diabese (dikes and sills) St. Francois Mountains Intrusive Suite St. Francois Mountains Volcanic Supergiroup 0 10 20

Oliver St John Gogarty.

Science.gov (United States)

Clarke, R W

1997-01-01

Oliver St John Gogarty--Otolaryngologist to fashionable Edwardian Dublin--was a distinguished poet and a Senator in the fledgling Irish Free State after its establishment in 1922. He numbered amongst his acquaintances the poet William Butler Yeats, the novelist James Joyce and a host of political and literary persona who helped to shape modern Ireland. He was satirised as 'stately plump Buck Mulligan' in Joyce's novel Ulysses.

Asymptomatic ST-depression during exercise testing in children and adolescents with type 1 diabetes mellitus and autonomic dysfunction

Directory of Open Access Journals (Sweden)

Dmitry Nikitich Laptev

2015-04-01

Full Text Available Aim. The aim of this study was to investigate cardiac autonomic function as assessed by ST dynamics during and post-exercise in children and adolescents with type 1 diabetes mellitus (T1DM. Materials and methods. The study included 71 young patients with T1DM. The patients were aged 9?18 years and had no history of macrovascular disease or renal disease, including microalbuminuria. Cardiac autonomic function was assessed using cardiovascular tests and 24-h ECG monitoring with automatic calculation of QT interval and heart rate variability parameters. Each patient underwent the physical working capacity 170 test. Results. The prevalence of cardiovascular autonomic neuropathy (CAN was 30.9%. The frequency of asymptomatic ST-segment depression increased during exercise in 10 (45.5% patients with CAN (CAN+ compared with 9 (18.4% patients without CAN (CAN-; p=0.042. During the recovery period, asymptomatic ST-segment depression was present in the first minute in 8 (36.4% CAN+ patients compared with 1 (2% CAN- patient (p=0.0003 and in the second minute in 5 (22.7% CAN+ patients compared with 1 (2% CAN- patient (p=0.0095. Conclusion. Children and adolescents with T1DM and impaired autonomic function have increased prevalence of asymptomatic ST-segment depression during and post-exercise. The presence of cardiovascular risk factors in children and adolescents with T1DM and CAN may contribute to the increased cardiovascular morbidity and mortality during adulthood in patients with T1DM.

Asymptomatic ST-depression during exercise testing in children and adolescents with type 1 diabetes mellitus and autonomic dysfunction

Directory of Open Access Journals (Sweden)

Dmitry Nikitich Laptev

2015-04-01

Full Text Available Aim. The aim of this study was to investigate cardiac autonomic function as assessed by ST dynamics during and post-exercise in children and adolescents with type 1 diabetes mellitus (T1DM.Materials and methods. The study included 71 young patients with T1DM. The patients were aged 9–18 years and had no history of macrovascular disease or renal disease, including microalbuminuria. Cardiac autonomic function was assessed using cardiovascular tests and 24-h ECG monitoring with automatic calculation of QT interval and heart rate variability parameters. Each patient underwent the physical working capacity 170 test.Results. The prevalence of cardiovascular autonomic neuropathy (CAN was 30.9%. The frequency of asymptomatic ST-segment depression increased during exercise in 10 (45.5% patients with CAN (CAN+ compared with 9 (18.4% patients without CAN (CAN-; p=0.042. During the recovery period, asymptomatic ST-segment depression was present in the first minute in 8 (36.4% CAN+ patients compared with 1 (2% CAN- patient (p=0.0003 and in the second minute in 5 (22.7% CAN+ patients compared with 1 (2% CAN- patient (p=0.0095.Conclusion. Children and adolescents with T1DM and impaired autonomic function have increased prevalence of asymptomatic ST-segment depression during and post-exercise. The presence of cardiovascular risk factors in children and adolescents with T1DM and CAN may contribute to the increased cardiovascular morbidity and mortality during adulthood in patients with T1DM.

Smart Social Networking: 21st Century Teaching and Learning Skills

Science.gov (United States)

Boholano, Helen B.

2017-01-01

Education in the 21st century highlights globalization and internationalization. Pre-service teachers in the 21st century are technology savvy. To effectively engage and teach generation Z students, preservice teachers will help the educational system meet this requirement. The educational systems must be outfitted with a prerequisite of ICT…

Imaging QRS complex and ST segment in myocardial infarction

DEFF Research Database (Denmark)

Bacharova, Ljuba; Bang, Lia E; Szathmary, Vavrinec

2014-01-01

BACKGROUND: Acute myocardial infarction creates regions of altered electrical properties of myocardium resulting in typical QRS patterns (pathological Q waves) and ST segment deviations observed in leads related to the MI location. The aim of this study was to present a graphical method for imaging...... the changes in the sequence of depolarization and the ST segment deviations in myocardial infarction using the Dipolar ElectroCARdioTOpography (DECARTO) method. MATERIAL AND METHODS: Simulated ECG data corresponding to intramural, electrically inactive areas encircled by transmural areas with slowed impulse...... propagation velocity in anteroseptal and inferior locations were used for imaging the altered sequence of depolarization and the ST vector. The ECGs were transformed to areas projected on the image surface so as to image the process of ventricular depolarization based on the orientation and magnitude...

Construction, testing, and initial operation of Fort St. Vrain PCRV

International Nuclear Information System (INIS)

Ople, F.S. Jr.; Neylan, A.J.

1975-01-01

The Fort St. Vrain (FSV) Nuclear Generating Station is the first station in the USA to use a prestressed concrete reactor vessel (PCRV). The PCRV was designed and constructed by General Atomic. Construction of the PCRV was completed in 1970; the pressure and leak tests were completed in 1971. The structural behavior of the PCRV has been monitored by installed instrumentation since start of construction. The highlights of the actual construction, testing, and initial operation of the PCRV, including a comparison of structural behavior, where possible, between observed data and analytical predictions. (U.S.)

76 FR 30018 - Safety Zone; Marysville Days Fireworks, St. Clair River, Marysville, MI

Science.gov (United States)

2011-05-24

...-AA00 Safety Zone; Marysville Days Fireworks, St. Clair River, Marysville, MI AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on St. Clair River, Marysville, MI. This zone is intended to restrict vessels from a portion of St. Clair River...

77 FR 29901 - Safety Zone; Marysville Days Fireworks, St. Clair River, Marysville, MI

Science.gov (United States)

2012-05-21

...-AA00 Safety Zone; Marysville Days Fireworks, St. Clair River, Marysville, MI AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on the St. Clair River, Marysville, Michigan. This zone is intended to restrict vessels from a portion of the St...

Structure and petroleum plays of the St. Lawrence Platform and Appalachians in southern Quebec : insights from interpretation of MRNQ seismic reflection data

Energy Technology Data Exchange (ETDEWEB)

Castonguay, S.; Lavoie, D. [Natural Resources Canada, Quebec, PQ (Canada). Geological Survey of Canada, Quebec Division; Dietrich, J. [Natural Resources Canada, Calgary, AB (Canada). Geological Survey of Canada; Laliberte, J.Y. [Ministere des Ressources naturelles et de la Faune du Quebec, Charlesbourg, QC (Canada). Direction generale des hydrocarbures et des biocarburants

2010-09-15

This paper presented the results of a study in which 3 regional seismic reflection lines originally acquired in 1978 were reprocessed and reinterpreted using current techniques and methodologies. The profiles cross the Chambly-Fortierville syncline and provide images of the St. Lawrence Platform and the Appalachian foreland thrust belt of southern Quebec, including one that spans the entire width of the southern Quebec Appalachians. Post-stack seismic data processing and time migration were used to improve the quality of the original seismic sections, allowing interpretations that provide new information on subsurface geology, such as the recognition of complex structural patterns in platform and foreland units, the presence of a triangle zone at the structural front, and the geometry of thrust slices of platform units and Appalachian thrust beds, as well as images of the internal Humber Zone, including back-thrust faults and mega thrust wedges. The Saint-Flavien natural gas-field and other potential targets in the St. Lawrence Platform and Appalachian Foreland are imaged in the seismic profiles. The study provided new insights into the structure, geological evolution, and petroleum potential of the St. Lawrence Platform and the Appalachian foreland thrust belt of southern Quebec, including a potential, previously unrecognized Ordovician hydrothermal dolomite play. The new subsurface interpretations give a clearer view of the major structure affecting the Utica Shale, providing new insights into the limits of the unconventional shale gas play in the St. Lawrence Platform. 53 refs., 8 figs.

St. John le calviniste, ou l’émule de Gil-Martin Charlotte Brontë’s Calvinist St. John Emulating James Hogg’s Gil-Martin

Directory of Open Access Journals (Sweden)

Jean Berton

2009-07-01

Full Text Available This article aims to show how far Hogg’s archetypal character, Gil-Martin, influenced Charlotte Brontë’s enigmatic character, St. John, who appears in chapters XXVI to XXXV and is mentioned again in the conclusion of Jane Eyre. Some unexpected words, like “glen”, in a greater Yorkshire area, operate as keywords to a “deep context” study in a neo-contextualist approach. Even though St. John cannot be mistaken for a double of Gil-Martin, a fair number of details tend to prove that James Hogg’s Private Memoirs and Confessions of a Justified Sinner deeply influenced Charlotte Brontë—both pride-driven St. John and Gil-Martin stand for demonic despotism. Yet, if Gil-Martin is a straightforward Gothic illustration of Satan, St. John is a reincarnation of a marble-cold Apollo in a dogma-trapped Calvinist. Brontë’s intention was not so much to denounce noxious excesses in religious beliefs as to set her heroine’s wise independence against nefarious male domination: whereas victimised Robert Wringhim is driven to despair and suicide, self-reliant Jane Eyre escapes from St. John’s grip. In both narratives relationships between men and women are shown as tragically warped by religious behavioural extravagance, but only the female character is granted a positive outcome to serve an optimistic view on life: Robert Wringhim is violently wrung out of the society of men and women, St. John Rivers, from “Marsh End”, blindly drifts away to his death in India, and airy Jane, of “Moor House”, wafts away to anchor to Edward Rochester, the sender of the airwave-born call.

Differentiating ST elevation myocardial infarction and nonischemic causes of ST elevation by analyzing the presenting electrocardiogram

DEFF Research Database (Denmark)

Jayroe, Jason B; Spodick, David H; Nikus, Kjell

2008-01-01

Guidelines recommend that patients with suggestive symptoms of myocardial ischemia and ST-segment elevation (STE) in > or =2 adjacent electrocardiographic leads should receive immediate reperfusion therapy. Novel strategies aimed to reduce door-to-balloon time, such as prehospital wireless...

ST ECS error handling and detector safety

CERN Document Server

Esperante Pereira, D

2010-01-01

This note describes the automatic operation sequences that the ECS implements in order to operate the ST detector in a safe and reliable way. First, the start-up sequences to set the detector in a well known state are described. In addition the possible ST detector states based on the status of the different detector elements will be defined. The states are of crucial interest for the safe operation of the detector when the LHC beam is ready. Besides, the ECS automatic actions taken in case of abnormal status of any of the detector elements are reported. Next, the operational alarm ranges and the error recovery mechanisms are mentioned.

Unintended and unwanted pregnancy in St. Lucia.

Science.gov (United States)

Denton, A B; Chase, W M; Scott, K

1994-09-01

Among 200 mothers interviewed in St. Lucia, 82.5% described their pregnancy as unintended and 44% as unwanted; 80% of women having an intended pregnancy and 94.6% having an unintended pregnancy were unmarried and 18.5% were teenagers. Mothers of unintended pregnancies were significantly younger, were of significantly higher parity and had begun sexual relations at a significantly earlier age than mothers of intended pregnancies; and, unlike mothers of planned pregnancies, their desired interpregnancy interval was significantly longer than the actual interval. These results and the sporadic and ineffective use of contraception in St. Lucia emphasize the need for improvements in fertility regulation in that country.

Recognized Obstructive Sleep Apnea is Associated With Improved In-Hospital Outcomes After ST Elevation Myocardial Infarction.

Science.gov (United States)

Mohananey, Divyanshu; Villablanca, Pedro A; Gupta, Tanush; Agrawal, Sahil; Faulx, Michael; Menon, Venugopal; Kapadia, Samir R; Griffin, Brian P; Ellis, Stephen G; Desai, Milind Y

2017-07-20

Obstructive sleep apnea (OSA) is an independent risk factor for many cardiovascular conditions such as coronary artery disease, myocardial infarction, systemic hypertension, pulmonary hypertension, and stroke. However, the association of OSA with outcomes in patients hospitalized for ST-elevation myocardial infarction remains controversial. We used the nation-wide inpatient sample between 2003 and 2011 to identify patients with a primary discharge diagnosis of ST-elevation myocardial infarction and then used the International Classification of Diseases, Clinical Modification code 327.23 to identify a group of patients with OSA. The primary outcome of interest was in-hospital mortality, and secondary outcomes were in-hospital cardiac arrest, length of stay and hospital charges. Our cohort included 1 850 625 patients with ST-elevation myocardial infarction, of which 1.3% (24 623) had documented OSA. OSA patients were younger and more likely to be male, smokers, and have chronic pulmonary disease, depression, hypertension, known history of coronary artery disease, dyslipidemia, obesity, and renal failure ( P ST-elevation myocardial infarction patients with recognized OSA had significantly decreased mortality compared with patients without OSA. Although patients with OSA had longer hospital stays and incurred greater hospital charges, there was no difference in incidence of in-hospital cardiac arrest. © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

Analysis of changes in sagging type ST-T segment induced by exercise. Assessment of regional myocardial blood flow using quantitative 13NH3 positron emission tomography

International Nuclear Information System (INIS)

Watanabe, Takuya; Akutsu, Yasushi; Okazaki, Osamu

1995-01-01

Regional myocardial blood flow (RMBF) associated with exercise-induced ST depression was assessed using 13 NH 3 positron emission tomography (PET) to determine the significance of horizontal and sagging type ST segments. The subjects were 25 patients with angina pectoris, 25 patients with myocardial infarction, and 5 healthy male volunteers. Eleven regions of interests (ROI) were prepared to calculate RMBF. ST segments were unchanged in 27 patients (Group A) and were depressed in 23 patients (Group B). A 10% increase in RMBF was significantly observed in Group A (74.1%) than Group B (34.8%). In Group B, ST depression was divided into horizontal type (8 patients) and sagging type (15 patients). According to the type of ST depression, RMBF was increased by 10% or more in 50% (4/8) for horizontal type and in 26.7% (4/15) for sagging type. These findings suggested that unfavorable increase in RMBF in stenosiss-related coronary vessels may contribute to the development of ST depression induced by exercise. A constant increase in RMBF in all ROIs, including those with unfavorable RMBF increase, may be involved in the occurrence of horizontal type ST depression; sagging type ST depression may, however, occur by an increased difference in blood flow between unfavorable and favorable RMBF. (N.K.)

ST/EL and ST/CV services for TI2 & TI8 LHC injection tunnels

CERN Document Server

Akhtar, S; CERN. Geneva. ST Division

2002-01-01

This paper describes the ST/EL and ST/CV services for TI2 & TI8 LHC injection tunnels. The cooling and ventilation part describes the requirements for design and installation of more than 10 km of pipeline that is going to be laid down in the tunnels. Main operating parameters as well as manufacture procedures are explained. Preliminary work schedule with the cost estimate is also presented. Electrical power will be distributed from the LHC side and the SPS side for the machine and the general services. All power converters will be installed on surface buildings. The link between the main bend converters and the main bend magnets will be realised with water-cooled cables. Rest of the magnets will be cabled by using conventional copper and aluminium cables. Due to long lengths of the injection tunnels a dry 18kV transformer will be installed in TJ8 to serve the general services for TI8. The same will apply to TI2 by installing a transformer at the bottom of the PMI2 shaft.

Effect of St.John's wort (Hypericum perforatum) oily extract for the care and treatment of pressure sores; a case report.

Science.gov (United States)

Yücel, Ali; Kan, Yüksel; Yesilada, Erdem; Akın, Onat

2017-01-20

Topical formulations such as oily extracts or ointments prepared with the flowering aerial parts of St. John's wort (Hypericum perforatum L., Hypericaceae) have been used in the management of a wide range dermatological problems including superficial wounds and burns, bruises, contusions and many others in the worldwide traditional medicines. This is the first case study reporting the beneficial effects of an oily extract of St. John's wort in the treatment of pressure sores in a intensive care unit (ICU) patient. The oily extract of St. John's wort was applied to a volunteer patient at ICU daily for forty successive days for wound care and treatment. Healing status was monitored macroscopically by measuring the wound size and stages at certain intervals as well as histopathological evaluation of the tissue sections taken at the initial and final dates of treatment. Evaluation of the results obtained from the macroscopical and histopathological experimentation have shown that oily extract of St. John's wort provided significant efficacy for the treatment of pressure sore wounds. St. John's wort oily extract may be suggested as a cost-effective option for the prevention or treatment of pressure sores in ICU patients. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

File list: ALL.Lar.10.AllAg.1st_instar [Chip-atlas[Archive

Lifescience Database Archive (English)

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File list: ALL.Lar.50.AllAg.1st_instar [Chip-atlas[Archive

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File list: ALL.Lar.20.AllAg.1st_instar [Chip-atlas[Archive

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File list: ALL.Lar.05.AllAg.1st_instar [Chip-atlas[Archive

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Multiple protein biomarker assessment for recombinant bovine somatotropin (rbST abuse in cattle.

Directory of Open Access Journals (Sweden)

Susann K J Ludwig

Full Text Available Biomarker profiling, as a rapid screening approach for detection of hormone abuse, requires well selected candidate biomarkers and a thorough in vivo biomarker evaluation as previously done for detection of growth hormone doping in athletes. The bovine equivalent of growth hormone, called recombinant bovine somatotropin (rbST is (illegally administered to enhance milk production in dairy cows. In this study, first a generic sample pre-treatment and 4-plex flow cytometric immunoassay (FCIA were developed for simultaneous measurement of four candidate biomarkers selected from literature: insulin-like growth factor 1 (IGF-1, its binding protein 2 (IGFBP2, osteocalcin and endogenously produced antibodies against rbST. Next, bovine serum samples from two extensive controlled rbST animal treatment studies were used for in vivo validation and biomarker evaluation. Finally, advanced statistic tools were tested for the assessment of biomarker combination quality aiming to correctly identify rbST-treated animals. The statistical prediction tool k-nearest neighbours using a combination of the biomarkers osteocalcin and endogenously produced antibodies against rbST proved to be very reliable and correctly predicted 95% of the treated samples starting from the second rbST injection until the end of the treatment period and even thereafter. With the same biomarker combination, only 12% of untreated animals appeared false-positive. This reliability meets the requirements of Commission Decision 2002/657/EC for screening methods in veterinary control. From the results of this multidisciplinary study, it is concluded that the osteocalcin - anti-rbST-antibodies combination represent fit-for-purpose biomarkers for screening of rbST abuse in dairy cattle and can be reliably measured in both the developed 4-plex FCIA as well as in a cost-effective 2-plex microsphere-based binding assay. This screening method can be incorporated in routine veterinary monitoring

Postcolonial Identity Politics, Language and the Schools in St. Lucia

Science.gov (United States)

St. Hilaire, Aonghas

2009-01-01

In the postcolonial era, a cultural nationalist movement has sought to elevate the status of St. Lucia's creole vernacular, Kweyol, and with some success--it is now the most visible symbol of St. Lucian national identity. This relatively new development has altered somewhat the historic linguistic status quo between the official, high status…

IDENTIFIKASI SURFAKTIN PADA PSEUDOMONAS FLUORESCENS ST1 PENGENDALI EFEKTIF PENYAKIT PUSTUL KEDELAI

Directory of Open Access Journals (Sweden)

Suskandini Ratih Dirmawati .

2011-11-01

Full Text Available Identification of surfactin in Pseudomonas fluorescens ST1 which effectively suppres soybean bacterial pustule.   Identification of surfactin in Pseudomonas fluorescens ST1 filtrate was conducted in Plant Pest and Disease Laboratory, Bogor Agriculture University.  The 48 hours cultured suspension of  P. fluorescens ST1 with 108 CFU/ml density was centrifuged to obtain the supernatant.  The supernatant was analyzed for its surfactin content by High Performance Liquid Chromatography with Colum ODS-5 and eluen acetonitril and acetat acid.  The result showed  that  surfactin was producted by P. fluorescens ST1 and this bioactive substance could suppres the bacterial pustule on soybean.

Penaeid prawns in the St Lucia Lake System: Post-larval recruitment ...

African Journals Online (AJOL)

Penaeid prawns in the St Lucia Lake System: Post-larval recruitment and the bait fishery. ... Recruitment of post-larval penaeid prawns and the bait prawn fishery in the St Lucia Lake System were monitored for ... AJOL African Journals Online.

Causal Relationship Model of the Information and Communication Technology Skill Affect the Technology Acceptance Process in the 21ST Century for Undergraduate Students

Directory of Open Access Journals (Sweden)

Thanyatorn Amornkitpinyo

2015-02-01

Full Text Available The objective of this study is to design a framework for a causal relationship model of the Information and Communication Technology skills that affect the Technology Acceptance Process (TAP for undergraduate students in the 21ST Century. This research uses correlational analysis. A consideration of the research methodology is divided into two sections. The first section involves a synthesis concept framework for process acceptance of the causal relationship model of the Information and Communication Technology skills that affect the Technology Acceptance Process for undergraduate students in the 21ST Century. The second section proposes the design concept framework of the model. The research findings are as follows: 1 The exogenous latent variables included in the causal relationship model of the Information and Communication Technology skills that affect the Technology Acceptance Process for undergraduate students in the 21ST Century are basic ICT skills and self-efficacy. 2 The mediating latent variables of the causal relationship model of the Information and Communication Technology skills that affect the Technology Acceptance Process for undergraduate students in the 21ST Century are from the TAM Model, these includes three components: 1 perceived usefulness, 2 perceived ease of use and 3 attitudes. 3 The outcome latent variable of the causal relationship model of the Information and Communication Technology skills that affect the Technology Acceptance Process for undergraduate students in the 21ST Century is behavioural intention.

"What Have the Humanities to Offer 21st-Century Europe?": Reflections of a Note Taker

Science.gov (United States)

Parker, Jan

2008-01-01

The Humanities have much to offer 21st-century Europe, in terms of both method and issues which may complement and correct those of Science and Social Science. These include, for instance, humanities' generation of plural narratives and plural explanations, of attention to singularity and complexity, and to others' sensibilities and ways of…

Immunogenicity of nuclear-encoded LTB:ST fusion protein from Escherichia coli expressed in tobacco plants.

Science.gov (United States)

Rosales-Mendoza, Sergio; Soria-Guerra, Ruth E; Moreno-Fierros, Leticia; Govea-Alonso, Dania O; Herrera-Díaz, Areli; Korban, Schuyler S; Alpuche-Solís, Ángel G

2011-06-01

Enterotoxigenic Escherichia coli (ETEC) is one of the main causative agents of diarrhea in infants and for travelers. Inclusion of a heat-stable (ST) toxin into vaccine formulations is mandatory as most ETEC strains can produce both heat-labile (LT) and ST enterotoxins. In this study, a genetic fusion gene encoding for an LTB:ST protein has been constructed and transferred into tobacco via Agrobacterium tumefaciens-mediated transformation. Transgenic tobacco plants carrying the LTB:ST gene are then subjected to GM1-ELISA revealing that the LTB:ST has assembled into pentamers and displays antigenic determinants from both LTB and ST. Protein accumulation of up to 0.05% total soluble protein is detected. Subsequently, mucosal and systemic humoral responses are elicited in mice orally dosed with transgenic tobacco leaves. This has suggested that the plant-derived LTB:ST is immunogenic via the oral route. These findings are critical for the development of a plant-based vaccine capable of eliciting broader protection against ETEC and targeting both LTB and ST. Features of this platform in comparison to transplastomic approaches are discussed.

Analysis and reconstructed modelling of the debris flow event of the 21st of July 2012 of St. Lorenzen (Styria, Austira)

Science.gov (United States)

Janu, Stefan; Mehlhorn, Susanne; Moser, Markus

2013-04-01

Analysis and reconstructed modelling of the debris flow event of the 21st of July 2012 of St. Lorenzen (Styria, Austria) Authors: Stefan Janu, Susanne Mehlhorn, Markus Moser The village of St. Lorenzen, in the Styrian Palten valley is situated on the banks of the Lorenz torrent, in which a debris flow event occurred in the early morning hours of the 21st of July 2012, causing catastrophic damage to residential buildings and other infrastructural facilities. In the ministry-approved hazard zone map of 2009, the flood water discharge and bedload volume associated with a 150-year event was estimated at 34 m³/s and 25,000 m³ respectively for the 5.84 km² catchment area. The bedload transport capacity of the torrent was classified as ranging from 'heavy' to 'capable of producing debris flows'. The dominant process type of the mass movement event may be described as a fine-grained debris flow. The damage in the residential area of St.Lorenzen was caused by a debris flow pulse in the lower reach of the Lorenz torrent. This debris flow pulse was in turn caused by numerous landslides along the middle reaches of the torrent, some of which caused blockages, ultimately leading to an outburst event in the main torrent. Discharge cross-sections ranging from 65 - 90 m², and over 100 m² in a few instances, were measured upstream of the St. Lorenzen residential area. Back-calculations of velocities yielded an average debris flow velocity along the middle reaches of the torrent between 11 and 16 m/s. An average velocity of 9 m/s was calculated for the debris flow at the neck of the alluvial fan directly behind the center of the village. Due to both the high discharge values as well as to the height of the mass movement deposits, the natural hazard event of 21 July 2012 in St. Lorenzen is clearly to be described as having had an extreme intensity. A total of 67 buildings were damaged along the Lorenz torrent, 7 of were completely destroyed. According to the Austrian Service for

A 3000 yr paleostorm record from St. Catherines Island, Georgia

Science.gov (United States)

Braun, Erick; Meyer, Brian; Deocampo, Daniel; Kiage, Lawrence M.

2017-09-01

Tropical cyclones (hurricanes in the northern hemisphere) are amongst the most devastating of the world's natural disasters and cause billions of dollars in damage every year. Data on the likelihood of a coastal site being struck by a major hurricane strike can potentially aid in planning and mitigation efforts that could save money and lives. However, forecasting requires data that are currently insufficient for the Georgia Bight. This study provides information to enhance the paleohurricane record by analysis of a 467 cm thick vibracore raised from St. Catherines Island, GA. Sediment geochemistry and foraminiferal assemblages indicate deposits attributable to seven paleohurricane events, five of which were likely major hurricanes when they made landfall on St. Catherines. Magnitudes were estimated by comparison to the overwash deposit left by ;The Sea Islands hurricane of 1893;, a major hurricane recorded by the recent sediment of St. Catherines Island. The St. Catherines record also shows a change in the activity levels on the Georgia coast with two distinct activity regimes over the past 3000 years.

RESTAURANT AND CAFETERIA SERVICES ARRANGEMENTS FOR MAY 1ST, 2001

CERN Multimedia

Restaurant Supervisory Committee

2001-01-01

1. Restaurants As Tuesday, May 1st, is an official CERN holiday, restaurants no 2 (DSR : Bldg. 504 - Meyrin) and no 3 (Avenance : Bldg. 866 - Prévessin) will be closed as from Monday, April 30 at 18h00. They will reopen on Wednesday, May 2nd at 6h30 (rest. no 2) and at 7h00 (rest. no 3). On May 1st, a limited service will be provided by restaurant no. 1 (COOP : Bldg. 501 - Meyrin) from 8h00 to 21h00 with hot meals served from 11h30 to 14h00 and from 18h00 to 19h30. 2. Satellite cafétérias All satellite cafétérias will be closed on May 1st. They will all operate normally on Monday, April 30, except for buildings 17 (Meyrin), 865 and 892 (Prévessin) which will be closed. 3. Newspaper stand The newspaper kiosque in building 501 will be closed on May 1st.

Fort St. Vrain defueling ampersand decommissioning considerations

International Nuclear Information System (INIS)

Warembourg, D.

1994-01-01

Fort St. Vrain Nuclear Generating Station (FSV) is one of the first commercial reactors to be decommissioned under NRC's decommissioning rule. The defueling and decommissioning of this 330 MWe High Temperature Gas Cooled Reactor (HTGR) has involved many challenges for Public Service Company of Colorado (PSC) including defueling to an Independent Spent Fuel Storage Installation (ISFSI), establishing decommissioning funding, obtaining regulatory approvals, arranging for waste disposal, and managing a large fixed price decommissioning contract. In 1990, a team comprised of the Westinghouse Corporation and Morrison Knudsen Corporation, with the Scientific Ecology Group as a major subcontractor, was contracted by PSC to perform the decommissioning under a fixed price contract. Physical work activities began in August 1992. Currently, physical dismantlement activities are about 45% complete, the project is on schedule, and is within budget

Operational experience at Fort St. Vrain

International Nuclear Information System (INIS)

Bramblett, G.C.; Fisher, C.R.; Swart, F.E.

1981-01-01

The Fort St. Vrain (FSV) station, a 330-MW(e) single reheat steam cycle powered by a high-temperature gas-cooled reactor (HTGR), is the first HTGR to enter commercial operation. Designed and built by General Atomic Company (GA), the plant is owned and operated by Public Service Company of Colorado (PSC). Many unique design features have been incorporated into this reactor system, including high-pressure helium as the primary system coolant, a graphite-moderated prismatic block core design, fission-product-containing carbide coatings on both fissile and fertile fuel particles, steam-driven helium circulators turning on water bearings, and once-through steam generators. All of these systems are contained in a prestressed concrete reactor vessel (PCRV). Extensive testing has been conducted during the rise to power following first criticality early in 1974 to verify system design performance. During this period, the plant has operated at power levels up to 70% and produced over one billion kilowatt hours of electricity. In 1979, the first refueling was conducted in conjunction with an extensive in-core inspection, the addition of in-core instrumentation, and a planned removal of a circulator for inspection. Later in the year, a scheduled shutdown was undertaken for surveillance tests, insertion of core region constraint devices (RCDs), and other maintenance. Fort St. Vrain has encountered problems of the type that would be expected in a first-of-a-kind system. The plant is currently restricted to 70% of design power by the Nuclear Regulatory Commission (NRC) pending resolution of the core region gas outlet temperature fluctuation problem. Even so, the basic performance of the HTGR concept and all of the unique design features have been successfully demonstrated. The system has been characterized by low personnel radiation exposures, operational flexibility, and long time afforded for status evaluation and response. (author)

Advanced ST Plasma Scenario Simulations for NSTX

International Nuclear Information System (INIS)

Kessel, C.E.; Synakowski, E.J.; Gates, D.A.; Harvey, R.W.; Kaye, S.M.; Mau, T.K.; Menard, J.; Phillips, C.K.; Taylor, G.; Wilson, R.

2004-01-01

Integrated scenario simulations are done for NSTX [National Spherical Torus Experiment] that address four primary milestones for developing advanced ST configurations: high β and high β N inductive discharges to study all aspects of ST physics in the high-beta regime; non-inductively sustained discharges for flattop times greater than the skin time to study the various current-drive techniques; non-inductively sustained discharges at high β for flattop times much greater than a skin time which provides the integrated advanced ST target for NSTX; and non-solenoidal start-up and plasma current ramp-up. The simulations done here use the Tokamak Simulation Code (TSC) and are based on a discharge 109070. TRANSP analysis of the discharge provided the thermal diffusivities for electrons and ions, the neutral-beam (NB) deposition profile, and other characteristics. CURRAY is used to calculate the High Harmonic Fast Wave (HHFW) heating depositions and current drive. GENRAY/CQL3D is used to establish the heating and CD [current drive] deposition profiles for electron Bernstein waves (EBW). Analysis of the ideal-MHD stability is done with JSOLVER, BALMSC, and PEST2. The simulations indicate that the integrated advanced ST plasma is reachable, obtaining stable plasmas with β ∼ 40% at β N 's of 7.7-9, I P = 1.0 MA, and B T = 0.35 T. The plasma is 100% non-inductive and has a flattop of 4 skin times. The resulting global energy confinement corresponds to a multiplier of H 98(y,2) 1.5. The simulations have demonstrated the importance of HHFW heating and CD, EBW off-axis CD, strong plasma shaping, density control, and early heating/H-mode transition for producing and optimizing these plasma configurations

A Correction Formula for the ST Segment Measurements for the AC-coupled Electrocardiograms

DEFF Research Database (Denmark)

Schmid, Ramun; Isaksen, Jonas; Leber, Remo

2017-01-01

Goal: The ST segment of an electrocardiogram (ECG) is very important for the correct diagnosis of an acute myocardial infarction. Most clinical ECGs are recorded using an AC-coupled ECG amplifier. It is well known, that first-order high-pass filters used for the AC coupling can affect the ST...... segment of an ECG. This effect is stronger the higher the filter's cut-off frequency is and the larger the QRS integral is. We present a formula that estimates these changes in the ST segment and therefore allows for correcting ST measurements that are based on an AC-coupled ECG. Methods: The presented...

[Treatment and management after acute coronary syndrome without ST-elevation].

Science.gov (United States)

Drogoul, Laurent; Scarlatti, Didier; Ferrari, Emile

2010-03-01

Coronary syndromes without ST elevation, previously known as unstable angina, are now more frequent than ST elevation myocardial infarction. Evidence-based studies should guide their management after hospital discharge. This management seeks to fulfill precise objectives and has been demonstrated to be effective in terms of survival. Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.

Transformations in Air Transportation Systems For the 21st Century

Science.gov (United States)

Holmes, Bruce J.

2004-01-01

Globally, our transportation systems face increasingly discomforting realities: certain of the legacy air and ground infrastructures of the 20th century will not satisfy our 21st century mobility needs. The consequence of inaction is diminished quality of life and economic opportunity for those nations unable to transform from the 20th to 21st century systems. Clearly, new thinking is required regarding business models that cater to consumers value of time, airspace architectures that enable those new business models, and technology strategies for innovating at the system-of-networks level. This lecture proposes a structured way of thinking about transformation from the legacy systems of the 20th century toward new systems for the 21st century. The comparison and contrast between the legacy systems of the 20th century and the transformed systems of the 21st century provides insights into the structure of transformation of air transportation. Where the legacy systems tend to be analog (versus digital), centralized (versus distributed), and scheduled (versus on-demand) for example, transformed 21st century systems become capable of scalability through technological, business, and policy innovations. Where air mobility in our legacy systems of the 20th century brought economic opportunity and quality of life to large service markets, transformed air mobility of the 21st century becomes more equitable available to ever-thinner and widely distributed populations. Several technological developments in the traditional aircraft disciplines as well as in communication, navigation, surveillance and information systems create new foundations for 21st thinking about air transportation. One of the technological developments of importance arises from complexity science and modern network theory. Scale-free (i.e., scalable) networks represent a promising concept space for modeling airspace system architectures, and for assessing network performance in terms of robustness

StAR Enhances Transcription of Genes Encoding the Mitochondrial Proteases Involved in Its Own Degradation

Science.gov (United States)

Bahat, Assaf; Perlberg, Shira; Melamed-Book, Naomi; Lauria, Ines; Langer, Thomas

2014-01-01

Steroidogenic acute regulatory protein (StAR) is essential for steroid hormone synthesis in the adrenal cortex and the gonads. StAR activity facilitates the supply of cholesterol substrate into the inner mitochondrial membranes where conversion of the sterol to a steroid is catalyzed. Mitochondrial import terminates the cholesterol mobilization activity of StAR and leads to mounting accumulation of StAR in the mitochondrial matrix. Our studies suggest that to prevent mitochondrial impairment, StAR proteolysis is executed by at least 2 mitochondrial proteases, ie, the matrix LON protease and the inner membrane complexes of the metalloproteases AFG3L2 and AFG3L2:SPG7/paraplegin. Gonadotropin administration to prepubertal rats stimulated ovarian follicular development associated with increased expression of the mitochondrial protein quality control system. In addition, enrichment of LON and AFG3L2 is evident in StAR-expressing ovarian cells examined by confocal microscopy. Furthermore, reporter studies of the protease promoters examined in the heterologous cell model suggest that StAR expression stimulates up to a 3.5-fold increase in the protease gene transcription. Such effects are StAR-specific, are independent of StAR activity, and failed to occur upon expression of StAR mutants that do not enter the matrix. Taken together, the results of this study suggest the presence of a novel regulatory loop, whereby acute accumulation of an apparent nuisance protein in the matrix provokes a mitochondria to nucleus signaling that, in turn, activates selected transcription of genes encoding the enrichment of mitochondrial proteases relevant for enhanced clearance of StAR. PMID:24422629

St 2-22 - Another Symbiotic Star with High-Velocity Bipolar Jets

Science.gov (United States)

Tomov, T.; Zamanov, R.; Gałan, C.; Pietrukowicz, P.

2017-09-01

We report the detection of high-velocity components in the wings of Hα emission line in spectra of symbiotic binary star St 2-22 obtained in 2005. This finding encouraged us to start the present investigation in order to show that this poorly-studied object is a jet-producing system. We have used high-resolution optical and low-resolution near-infrared spectra, as well as available optical and infrared photometry, to evaluate some physical parameters of the St 2-22 components and characteristics of the jets. We confirm that St 2-22 is a S-type symbiotic star. Our results demonstrate that an unnoticed outburst, similar to those in classical symbiotic systems, occurred in the first half of 2005. During the outburst, collimated bipolar jets were ejected by the hot component of St 2-22 with an average velocity of about 1700 km/s.

Impact of Clinical Presentation (Stable Angina Pectoris vs Unstable Angina Pectoris or Non-ST-Elevation Myocardial Infarction vs ST-Elevation Myocardial Infarction) on Long-Term Outcomes in Women Undergoing Percutaneous Coronary Intervention With Drug-Eluting Stents

DEFF Research Database (Denmark)

Giustino, Gennaro; Baber, Usman; Stefanini, Giulio Giuseppe

2015-01-01

The long-term risk associated with different coronary artery disease (CAD) presentations in women undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES) is poorly characterized. We pooled patient-level data for women enrolled in 26 randomized clinical trials. Of 11......,577 women included in the pooled database, 10,133 with known clinical presentation received a DES. Of them, 5,760 (57%) had stable angina pectoris (SAP), 3,594 (35%) had unstable angina pectoris (UAP) or non-ST-segment-elevation myocardial infarction (NSTEMI), and 779 (8%) had ST......-segment-elevation myocardial infarction (STEMI) as clinical presentation. A stepwise increase in 3-year crude cumulative mortality was observed in the transition from SAP to STEMI (4.9% vs 6.1% vs 9.4%; p clinical...

Karvian seurakunnan henkilöstötilinpäätös

OpenAIRE

Vaskela, Soila

2008-01-01

Tässä opinnäytetyössä tutkittiin yleisesti sekä käytännössä henkilöstötilinpäätöksen tarkoitusta ja sisältöä. Kohdeorganisaation eli Karvian seurakunnan avulla rakennettiin käytännön esimerkki seurakunnan ensimmäisestä henkilöstötilinpäätöksestä. Tutkimuksen tavoitteena oli löytää oikeat ratkaisut henkilöstötilinpäätöksen rakentamiseen organisaatiossa, jossa kyseinen asiakirja ei vielä ole tunnettu. Lisäksi tavoitteena oli laatia seurakunnalle käyttökelpoinen henkilöstötilinpäätösmalli, jota ...

Fort St. Vrain hot functional test results

International Nuclear Information System (INIS)

Phelps, R.D.

1974-01-01

A description is given of Fort St. Vrain hot functional tests performed to evaluate the initial nonnuclear performance of the primary coolant system and the associated effects on the various internal components of the reactor vessel and primary coolant system. The components included the twelve steam generator modules, the four helium circulators, the PCRV thermal barrier and liner coolant system, the helium purification system, and the primary and secondary closures at each of the PCRV penetrations. Additional objectives included analysis of the parallel operation of the four helium circulators and the performance of several circulator start/stop transients under various conditions of primary coolant temperature and pressure. Vibration and acoustical phenomena within the vessel were measured, recorded, and compared to theoretical analyses; a verification of reverse flow in the shutdown loop steam generator during one loop operation was performed; the PCRV was again observed for its structural response to internal pressure; and comparisons were made relative to data recorded during the initial pressure test completed in July 1971. (U.S.)

Drinking games and contextual factors of 21st birthday drinking.

Science.gov (United States)

Neighbors, Clayton; Rodriguez, Lindsey M; Rinker, Dipali V; DiBello, Angelo M; Young, Chelsie M; Chen, Chun-Han

2014-09-01

21st birthday celebrations are among the highest risks for alcohol use throughout emerging adulthood and celebrants often experience a range of alcohol-related consequences. The present research considered what happens when drinking games are paired with an already high-risk event (i.e., 21st birthday celebrations) and how drinking games compare with other contextual factors on 21st birthdays. Approximately four days after turning 21, 1124 college students (55% women) completed an online survey assessing alcohol use and related consequences experienced during their birthday celebrations. Participants were also asked whether drinking games and other contextual factors were associated with their celebrations. Overall, 18% of participants reported playing drinking games during their 21st birthday celebrations. These individuals reported consuming more alcohol, had higher estimated BACs, and experienced more negative consequences than those who did not play drinking games. The association between playing drinking games and alcohol use and negative consequences was stronger for men. The effect of drinking games on negative consequences was mediated through elevated BAC levels. Receiving bar specials, having drinks purchased, playing drinking games, and loud music were uniquely and significantly associated with all alcohol outcomes. Together, these results suggest that drinking games are part of a larger context of risk contributing to extreme drinking on 21st birthdays. Furthermore, these results will help to facilitate interventions that are more individually tailored to target specific contextual risks, behaviors, and events.

Studies of 21st-Century Precipitation Trends Over West Africa

Science.gov (United States)

Druyan, Leonard M.

2010-01-01

West Africa includes a semi-arid zone between the Sahara Desert and the humid Gulf of Guinea coast, approximately between 10 N and 20 N, which is irrigated by summer monsoon rains. This article refers to the region as the Sahel. Rain-fed agriculture is the primary sustenance for Sahel populations, and severe droughts (in the 1970s and 1980s), therefore, have devastating negative societal impacts. The future frequency of Sahel droughts and the evolution of its hydrological balance are therefore of great interest. The article reviews 10 recent research studies that attempt to discover how climate changes will affect the hydrology of the Sahel throughout the 21st century. All 10 studies rely on atmosphere ocean global climate model (AOGCM) simulations based on a range of greenhouse gas emissions scenarios. Many of the simulations are contained in the Intergovernmental Panel on Climate Change archives for Assessment Reports #3 and #4. Two of the studies use AOGCM data to drive regional climate models. Seven studies make projections for the first half of the 21st century and eight studies make projections for the second half. Some studies make projections of wetter conditions and some predict more frequent droughts, and each describes the atmospheric processes associated with its prediction. Only one study projects more frequent droughts before 2050, and that is only for continent-wide degradation in vegetation cover. The challenge to correctly simulate Sahel rainfall decadal trends is particularly daunting because multiple physical mechanisms compete to drive the trend upwards or downwards. A variety of model deficiencies, regarding the simulation of one or more of these physical processes, taints models climate change projections. Consequently, no consensus emerges regarding the impact of anticipated greenhouse gas forcing on the hydrology of the Sahel in the second half of the 21st century.

Myocardial Hemorrhage After Acute Reperfused ST-Segment–Elevation Myocardial Infarction

Science.gov (United States)

Carrick, David; Haig, Caroline; Ahmed, Nadeem; McEntegart, Margaret; Petrie, Mark C.; Eteiba, Hany; Hood, Stuart; Watkins, Stuart; Lindsay, M. Mitchell; Davie, Andrew; Mahrous, Ahmed; Mordi, Ify; Rauhalammi, Samuli; Sattar, Naveed; Welsh, Paul; Radjenovic, Aleksandra; Ford, Ian; Oldroyd, Keith G.

2016-01-01

Background— The success of coronary reperfusion therapy in ST-segment–elevation myocardial infarction (MI) is commonly limited by failure to restore microvascular perfusion. Methods and Results— We performed a prospective cohort study in patients with reperfused ST-segment–elevation MI who underwent cardiac magnetic resonance 2 days (n=286) and 6 months (n=228) post MI. A serial imaging time-course study was also performed (n=30 participants; 4 cardiac magnetic resonance scans): 4 to 12 hours, 2 days, 10 days, and 7 months post reperfusion. Myocardial hemorrhage was taken to represent a hypointense infarct core with a T2* value of hemorrhage 2 days post MI was associated with clinical characteristics indicative of MI severity and inflammation. Myocardial hemorrhage was a multivariable associate of adverse remodeling (odds ratio [95% confidence interval]: 2.64 [1.07–6.49]; P=0.035). Ten (4%) patients had a cardiovascular cause of death or experienced a heart failure event post discharge, and myocardial hemorrhage, but not microvascular obstruction, was associated with this composite adverse outcome (hazard ratio, 5.89; 95% confidence interval, 1.25–27.74; P=0.025), including after adjustment for baseline left ventricular end-diastolic volume. In the serial imaging time-course study, myocardial hemorrhage occurred in 7 (23%), 13 (43%), 11 (33%), and 4 (13%) patients 4 to 12 hours, 2 days, 10 days, and 7 months post reperfusion. The amount of hemorrhage (median [interquartile range], 7.0 [4.9–7.5]; % left ventricular mass) peaked on day 2 (Phemorrhage and microvascular obstruction follow distinct time courses post ST-segment–elevation MI. Myocardial hemorrhage was more closely associated with adverse outcomes than microvascular obstruction. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT02072850. PMID:26763281

Responsiveness summary for the engineering evaluation/cost analysis for decontamination at the St. Louis Downtown Site, St. Louis, Missouri

International Nuclear Information System (INIS)

Picel, M.H.; Peterson, J.M.; Williams, M.J.

1991-12-01

The US Department of Energy (DOE) is responsible for conducting remedial actions at the Mallinckrodt Chemical Plant, also referred to as the St. Louis Downtown Site (SLDS), located in the city of St. Louis, Missouri. Remedial activities at the SLDS are being carried out under DOE's Formerly Utilized Sites Remedial Action Program (FUSRAP) as part of the overall cleanup planned for three noncontiguous areas in St. Louis, which are collectively referred to as the St. Louis Site. Potential response action alternatives for managing the contaminated material generated at the SLDS have been evaluated in accordance with US Environmental Protection Agency (EPA) guidance for conducting interim actions under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), as amended. An engineering evaluation/cost analysis (EE/CA) report was prepared to document this process. On the basis of the analysis presented in the EE/CA, the preferred alternative for the management of contaminated wastes generated by DOE-supported plant activities is the provision of temporary storage capacity, which can be made available by modifying an existing building (i.e., Building 116) at SLDS. This alternative would enable DOE and Mallinckrodt to coordinate efforts to prevent the uncontrolled relocation of contamination and ensure that ultimate site cleanup objectives are not complicated by plant activities implemented by Mallinckrodt. The EE/CA, dated May 1991, was issued to the general public on June 7, 1991, and a public comment period was held from June 7 through July 10, 1991, in accordance with the public participation process identified in CERCLA. Comments on the proposed action were received in writing from the Missouri Department of Health, private citizen Kay Drey, and the EPA Region 7. This responsiveness summary has been prepared to respond to issues identified in these comment letters on the proposed action

Long-term survival and causes of death in patients with ST-elevation acute coronary syndrome without obstructive coronary artery disease

DEFF Research Database (Denmark)

Andersson, Hedvig Bille; Pedersen, Frants; Engstrøm, Thomas

2018-01-01

Aims: We aimed to study survival and causes of death in patients with ST-elevation acute coronary syndrome (STE-ACS) with and without obstructive coronary artery disease (CAD). Methods and results: We included 4793 consecutive patients with STE-ACS triaged for acute coronary angiography at a larg...... than patients with obstructive CAD. Causes of death were less often cardiovascular. This suggests that STE-ACS patients without obstructive CAD warrant medical attention and close follow-up.......Aims: We aimed to study survival and causes of death in patients with ST-elevation acute coronary syndrome (STE-ACS) with and without obstructive coronary artery disease (CAD). Methods and results: We included 4793 consecutive patients with STE-ACS triaged for acute coronary angiography at a large...

Promoting the 21st century scientific literacy skills through innovative chemistry instruction

Science.gov (United States)

Rahayu, Sri

2017-12-01

Students need to be equipped with the 21st century skills/capabilities to ensure their competitiveness in the knowledge era. So, it is imperative that education at school should be changed in order to fulfill the need. However, there is not any specified approach on how to educate young students for the 21st century capabilities. Regardless the impediment for ts exist, we need to construct an innovative instruction that can develop the students' 21st century skills by incorporating the skills needed, based on contemporary theory of learning, necessary context of learning and appropriate assessment in a chemistry subject matter. This paper discuss the feasible skills to be promoted through chemistry course. Those skills/capabilities are scientific literacy, higher order thinking, communicationand collaboration and curiosity. The promoted are called the 21st century scientific literacy skills in which it emphasis on scientific literacy and embedded the other 21st century skills into the innovative chemistry instruction. The elements involve in the instruction such as inquiry and constructivist approach, nature of science, contemporary/socioscientific issues, critical thinking (higher order thinking).

21ST-CENTURY TEACHERS: THE STUDENTS’ PERSPECTIVES

Directory of Open Access Journals (Sweden)

Maida Norahmi

2017-03-01

Full Text Available The issues regarding the demands of creative, innovative, and professional teachers are certainly on the concern of stakeholders and practitioners in education. Substantial efforts were conducted by the government to meet the 21st-century teachers having the four competencies required for being a teacher and coping with the needs of modern education. A survey research was conducted to collect respondents’ opinion as the main source of data to describe whether the 21st-century teachers are on the demands and to gain information that the students have a similar perception to teacher’s competencies required by the government. Seventy-five questionnaires related to the competencies were given to students of English Education Study Program of 2013 to 2016. The questionnaires were aimed at collecting written information dealing with what the students perceived towards the activities implemented by teachers in the process of teaching and learning. The result of questionnaire analysis revealed that most students expected the 21st-century teachers to have skills in teaching and in connecting it with the development of today’s technology and today’s student characteristics. The data also showed that the students constructed the same characteristics of teacher’s competencies required by the government regarding pedagogy, personality, sociality, and professionality.

Comparative Genomic Characterization of the Highly Persistent and Potentially Virulent Cronobacter sakazakii ST83, CC65 Strain H322 and Other ST83 Strains

Directory of Open Access Journals (Sweden)

Hannah R. Chase

2017-06-01

Full Text Available Cronobacter (C. sakazakii is an opportunistic pathogen and has been associated with serious infections with high mortality rates predominantly in pre-term, low-birth weight and/or immune compromised neonates and infants. Infections have been epidemiologically linked to consumption of intrinsically and extrinsically contaminated lots of reconstituted powdered infant formula (PIF, thus contamination of such products is a challenging task for the PIF producing industry. We present the draft genome of C. sakazakii H322, a highly persistent sequence type (ST 83, clonal complex (CC 65, serotype O:7 strain obtained from a batch of non-released contaminated PIF product. The presence of this strain in the production environment was traced back more than 4 years. Whole genome sequencing (WGS of this strain together with four more ST83 strains (PIF production environment-associated confirmed a high degree of sequence homology among four of the five strains. Phylogenetic analysis using microarray (MA and WGS data showed that the ST83 strains were highly phylogenetically related and MA showed that between 5 and 38 genes differed from one another in these strains. All strains possessed the pESA3-like virulence plasmid and one strain possessed a pESA2-like plasmid. In addition, a pCS1-like plasmid was also found. In order to assess the potential in vivo pathogenicity of the ST83 strains, each strain was subjected to infection studies using the recently developed zebrafish embryo model. Our results showed a high (90–100% zebrafish mortality rate for all of these strains, suggesting a high risk for infections and illness in neonates potentially exposed to PIF contaminated with ST83 C. sakazakii strains. In summary, virulent ST83, CC65, serotype CsakO:7 strains, though rarely found intrinsically in PIF, can persist within a PIF manufacturing facility for years and potentially pose significant quality assurance challenges to the PIF manufacturing industry.

9th International Frumkin symposium: Electrochemical technologies and materials for 21st century. Abstracts

Energy Technology Data Exchange (ETDEWEB)

NONE

2010-07-01

Abstracts of the 9th International Frumkin symposium: Electrochemical technologies and materials for 21st century are presented. The symposium was held 24-29 October 2010 in Moscow. The symposium included the following microsymposiums: Electrical double layer and electrochemical kinetics (from phenomenological to molecular level); New processes, materials and devices for successful electrochemical transformation of energy; Corrosion and protection of materials; General and local corrosion; Electroactive composition materials; Bioelectrochemistry. The Frumkin symposium includes plenary lectures, oral and poster presentations. Official language of the symposium is English

9th International Frumkin symposium: Electrochemical technologies and materials for 21st century. Abstracts

International Nuclear Information System (INIS)

2010-01-01

Abstracts of the 9th International Frumkin symposium: Electrochemical technologies and materials for 21st century are presented. The symposium was held 24-29 October 2010 in Moscow. The symposium included the following microsymposiums: Electrical double layer and electrochemical kinetics (from phenomenological to molecular level); New processes, materials and devices for successful electrochemical transformation of energy; Corrosion and protection of materials; General and local corrosion; Electroactive composition materials; Bioelectrochemistry. The Frumkin symposium includes plenary lectures, oral and poster presentations. Official language of the symposium is English [ru

Organisation des travaux ST-CV

CERN Document Server

Martel, C; CERN. Geneva. ST Division

2003-01-01

Débutée il y a deux ans, la phase de construction des installations de refroidissement du LHC a atteint en 2003 son apogée. De nombreux autres projets sont également gérés par le groupe dans divers secteurs du laboratoire. La spécificité du groupe est de réaliser des installations complexes impliquant des spécificités diverses telles qu’aéraulique, hydraulique, électrique, etc. Pour faire face à ces demandes la section travaux du groupe ST CV a adopté une structure capable de réaliser ces divers projets avec un minimum de personnel. La première partie de ce document décrit l’organisation de la section travaux ST CV. Dans une deuxième partie, les auteurs dressent un état des lieux des chantiers par projet en décrivant plus particulièrement les activités dans les domaines du traitement d’air et de refroidissement par eau.

76 FR 68101 - Safety Zone; Art Gallery Party St. Pete 2011 Fireworks Display, Tampa Bay, St. Petersburg, FL

Science.gov (United States)

2011-11-03

... questions on this temporary final rule, call or email Marine Science Technician First Class Nolan L. Ammons, Sector St. Petersburg Prevention Department, Coast Guard; telephone (813) 228-2191, email Nolan.L.Ammons...

ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues

DEFF Research Database (Denmark)

Marcos, Nuno T; Bennett, Eric P; Gomes, Joana

2011-01-01

Sialyl-Tn is a simple mucin-type carbohydrate antigen aberrantly expressed in gastrointestinal adenocarcinomas and in the precursor lesion intestinal metaplasia. Sialyl-Tn tumour expression is an independent indicator of poor prognosis. We have previously shown in vitro that ST6GalNAc-I and ST6GalNAc......-II sialyltransferases can synthesize sialyl-Tn. The aim of the present study was to establish whether ST6GalNAc-I is the major enzyme responsible for the expression of sialyl-Tn. We used a model of CHO-ldlD cells producing only MUC1-Tn glycoform and showed that ST6GalNAc-I is the key-enzyme leading to sialyl......-Tn biosynthesis. We developed novel monoclonal antibodies specific for ST6GalNAc-I and evaluated its expression in gastrointestinal tissues. ST6GalNAc-I was detected in normal colon mucosa co-localized with O-acetylated sialyl-Tn. Expression was largely unaltered in colorectal adenocarcinomas. In contrast, we...

ST proteins, a new family of plant tandem repeat proteins with a DUF2775 domain mainly found in Fabaceae and Asteraceae.

Science.gov (United States)

Albornos, Lucía; Martín, Ignacio; Iglesias, Rebeca; Jiménez, Teresa; Labrador, Emilia; Dopico, Berta

2012-11-07

Many proteins with tandem repeats in their sequence have been described and classified according to the length of the repeats: I) Repeats of short oligopeptides (from 2 to 20 amino acids), including structural cell wall proteins and arabinogalactan proteins. II) Repeats that range in length from 20 to 40 residues, including proteins with a well-established three-dimensional structure often involved in mediating protein-protein interactions. (III) Longer repeats in the order of 100 amino acids that constitute structurally and functionally independent units. Here we analyse ShooT specific (ST) proteins, a family of proteins with tandem repeats of unknown function that were first found in Leguminosae, and their possible similarities to other proteins with tandem repeats. ST protein sequences were only found in dicotyledonous plants, limited to several plant families, mainly the Fabaceae and the Asteraceae. ST mRNAs accumulate mainly in the roots and under biotic interactions. Most ST proteins have one or several Domain(s) of Unknown Function 2775 (DUF2775). All deduced ST proteins have a signal peptide, indicating that these proteins enter the secretory pathway, and the mature proteins have tandem repeat oligopeptides that share a hexapeptide (E/D)FEPRP followed by 4 partially conserved amino acids, which could determine a putative N-glycosylation signal, and a fully conserved tyrosine. In a phylogenetic tree, the sequences clade according to taxonomic group. A possible involvement in symbiosis and abiotic stress as well as in plant cell elongation is suggested, although different STs could play different roles in plant development. We describe a new family of proteins called ST whose presence is limited to the plant kingdom, specifically to a few families of dicotyledonous plants. They present 20 to 40 amino acid tandem repeat sequences with different characteristics (signal peptide, DUF2775 domain, conservative repeat regions) from the described group of 20 to 40

Superconducting poloidal field magnet engineering for the ARIES-ST

International Nuclear Information System (INIS)

Bromberg, Leslie; Pourrahimi, S.; Schultz, J.H.; Titus, P.; Jardin, S.; Kessel, C.; Reiersen, W.

2003-01-01

The critical issues of the poloidal systems for the ARIES-ST design have been presented in this paper. Because of the large plasma current and the need of highly shaped plasmas, the poloidal field (PF) coils should be located inside the toroidal field in order to reduce their current. Even then, the divertor coils carry large currents. The ARIES-ST PF coils are superconducting using the internally cooled cable-in-conduit conductor. The peak self field in the divertor coils is about 15 T and the highest field in the non-divertor coils is about 6 T. The PF magnets have built-in margins that are sufficient to survive disruptions without quenching. The costing study indicates that the specific cost of the PF system is $80/kg. Detailed design and trade-off studies of ARIES-ST are presented and remaining R and D issues are identified

The Transformation of Evaluation into a Collaboration: A Vision of Evaluation in the 21st Century.

Science.gov (United States)

Fetterman, David M.

2001-01-01

Evaluation in the 21st century will be characterized by critical and collaborative relationships, and citizens will include a basic knowledge of evaluation as part of their democratic literacy skills. Funders, program, staff, and participants will acquire the capacity to monitor and assess critical aspects of their own performance. (SLD)

[Observation on therapeutic effect of electroacupuncture at Tianshu (ST 25) with deep needling technique on functional constipation].

Science.gov (United States)

Wang, Cheng-Wei; He, Hong-Bo; Li, Ning; Wen, Qian; Liu, Zhi-Shun

2010-09-01

To probe into a better therapeutic method for functional constipation. Ninety-five cases of functional constipation were randomly divided into deep puncture at ST 25 group (48 cases), shallow puncture at ST 25 group (24 cases) and medication group (23 cases). In deep puncture at ST 25 group, Tianshu (ST 25) was punctured deeply to the peritoneum, with electric stimulation. In shallow puncture at ST 25 group, Tianshu (ST 25) was punctured shallowly, 5 mm beneath the skin, with electric stimulation. In medication group, Duphalac was administered orally. These cases were treated continuously for 4 weeks in 3 groups and followed up for 6 months. It was to observe the numbers of person who had defecation 4 times a week, difference in weekly defecation frequency and the difference in the Cleveland Clinic Score (CCS). In deep puncture at ST 25 group, the frequency of weekly defecation and the numbers of person who had defecation 4 times a week increased and CCS decreased, which were similar to the efficacy in shallow puncture at ST 25 group (all P > 0.05). But the efficacy of both ST 25 groups was superior to that in medication group (both P deep puncture at ST 25 group acted more quickly than either shallow puncture at ST 25 group or medication group and its efficacy remained much longer. The deep puncture at ST 25 with electric stimulation presents similar efficacy on functional constipation as shallow puncture at ST 25, but it acts more quickly than shallow puncture at ST 25, both of them are more advantageous than medication and the long-term efficacy is better.

77 FR 42642 - Safety Zone; City of Ogdensburg Fireworks, St. Lawrence River, Ogdensburg, NY

Science.gov (United States)

2012-07-20

...-AA00 Safety Zone; City of Ogdensburg Fireworks, St. Lawrence River, Ogdensburg, NY AGENCY: Coast Guard... portion of the St. Lawrence River during the City of Ogdensburg Fireworks display. This temporary safety... as follows: Sec. 165.T09-0608 Safety Zone; City of Ogdensburg Fireworks, St. Lawrence River...

St George Acute Care Team: the local variant of crisis resolution model of care.

Science.gov (United States)

Cupina, Denise D; Wand, Anne P F; Phelan, Emma; Atkin, Rona

2016-10-01

The objective of this study was to describe functioning and clinical activities of the St George Acute Care Team and how it compares to the typical crisis resolution model of care. Descriptive data including demographics, sources of referral, type of clinical intervention, length of stay, diagnoses and outcomes were collected from records of all patients who were discharged from the team during a 10 week period. There were 677 referrals. The team's functions consisted of post-discharge follow-up (31%), triage and intake (30%), case management support (23%) and acute community based assessment and treatment (16%). The average length of stay was 5 days. The majority of patients were diagnosed with a mood (23%) or a psychotic (25%) disorder. Points of contrast to other reported crisis resolution teams include shorter length of stay, relatively less focus on direct clinical assessment and more telephone follow-up and triage. St George Acute Care Team provides a variety of clinical activities. The focus has shifted away from the original model of crisis resolution care to meet local and governmental requirements. © The Royal Australian and New Zealand College of Psychiatrists 2016.

Water quality and discharge data for St. Joseph Bay, Florida, 1997-98

Science.gov (United States)

Berndt, M.P.; Franklin, M.A.

1999-01-01

Historical data were compiled on water quality and water levels for the St. Joseph Bay area to assess quality of possible sources of land-derived water into the Bay. Ground-water quality data were compiled from Florida Department of Environmental Protection and surface-water quality data were compiled from U.S.Geological Survey files. Water-quality and water-level data were measured during two sample collection periods in October 1997 and March 1998 to determine water-quality and discharge rates in St. Joseph Bay under two sets of flow conditions. Measurements in the Bay included water level, temperature, pH, specific conductance, dissolved oxygen, and turbidity. Median pH in water from the surficial, intermediate and Floridan aquifer systems ranged from 4.8 to 7.8, and median specific conductance values were less than 500 microsiemens per centimeter. Median nutrient concentrations-- nitrate plus nitrite, ammonia and phosphorus--in the three aquifers were less than 0.5 milligrams per liter. The median pH was 7.0 and the median specific conductance was 81 microsiemens per centimeter for two samples from the Chipola River distribution canal. Water level data were obtained for several wells near St. Joseph Bay but only two wells yielded sufficient data to plot hydrographs. Measurements in St. Joseph Bay during the October and March collection periods were similar for pH and turbidity but differed for temperature, specific conductance and dissolved oxygen. The median temperature was 20.6 degrees Celsius in October and 15.4 degrees Celsius in March, median specific conductance was 39,500 microsiemens per centimeter in October and 43,300 microsiemens per centimeter in March, and median dissolved oxygen was 7.6 milligrams per liter in October and 8.3 milligrams per liter in March. The range in water levels over a tidal cycle in St. Joseph Bay on October 29, 1997 was about 1 foot. During a 24-hour tidal cycle on October 29, 1997, estimated hourly discharge varied from

Identifying 21st Century STEM Competencies Using Workplace Data

Science.gov (United States)

Jang, Hyewon

2016-04-01

Gaps between science, technology, engineering, and mathematics (STEM) education and required workplace skills have been identified in industry, academia, and government. Educators acknowledge the need to reform STEM education to better prepare students for their future careers. We pursue this growing interest in the skills needed for STEM disciplines and ask whether frameworks for 21st century skills and engineering education cover all of important STEM competencies. In this study, we identify important STEM competencies and evaluate the relevance of current frameworks applied in education using the standardized job-specific database operated and maintained by the US Department of Labor. Our analysis of the importance of 109 skills, types of knowledge and work activities, revealed 18 skills, seven categories of knowledge, and 27 work activities important for STEM workers. We investigate the perspectives of STEM and non-STEM job incumbents, comparing the importance of each skill, knowledge, and work activity for the two groups. We aimed to condense dimensions of the 52 key areas by categorizing them according to the Katz and Kahn (1978) framework and testing for inter-rater reliability. Our findings show frameworks for 21st century skills and engineering education do not encompass all important STEM competencies. Implications for STEM education programs are discussed, including how they can bridge gaps between education and important workplace competencies.

NASA-UVA Light Aerospace Alloy and Structures Technology Program (LA2ST). Research on Materials for the High Speed Civil Transport

Science.gov (United States)

Gangloff, Richard P.; Starke, Edgar A., Jr.; Kelly, Robert G.; Scully, John R.; Stoner, Glenn E.; Wert, John A.

1997-01-01

Since 1986, the NASA-Langley Research Center has sponsored the NASA-UVa Light Alloy and Structures Technology (LA2ST) Program at the University of Virginia (UVa). The fundamental objective of the LA2ST program is to conduct interdisciplinary graduate student research on the performance of next generation, light-weight aerospace alloys, composites and thermal gradient structures. The LA2ST program has aimed to product relevant data and basic understanding of material mechanical response, environmental/corrosion behavior, and microstructure; new monolithic and composite alloys; advanced processing methods; measurement and modeling advances; and a pool of educated graduate students for aerospace technologies. The scope of the LA2ST Program is broad. Research areas include: (1) Mechanical and Environmental Degradation Mechanisms in Advanced Light Metals and Composites, (2) Aerospace Materials Science, (3) Mechanics of materials for Aerospace Structures, and (4) Thermal Gradient Structures. A substantial series of semi-annual progress reports issued since 1987 documents the technical objectives, experimental or analytical procedures, and detailed results of graduate student research in these topical areas.

Moscow and St. Petersburgpsychological schools: from opposition to friendship

Directory of Open Access Journals (Sweden)

Victor M. Allakhverdov

2016-09-01

Full Text Available The paper is an attempt to summarize the interaction of the two largest schools of psychology in Russia: the psychological schools of Moscow and St. Petersburg. The paper is a sketch dedicated to the 50th anniversary of the psychological faculties of Moscow and St. Petersburg, and should not be appreciated as a historical treatise. Tense ties between the psychological schools, that originate in the distant past, have gone through different historical stages. Slavophilevs Westernizer traditions affected the initial difference in these schoolsemerging into the opposition: either the human being is studied entirety with his/her vast subjective experience, but losing the reliability of our statements (peculiarity of Moscow school, or we study the human being accurately using objective methods, but losing the integrity of our ideas (peculiarity of St.-Petersburg school. Both psychological schools, having gone through the ups and downs, have retained their identity and their emphasis on research. Moscow scholars in their studies are aimed to larger issues and still rely on large-scale Vygotsky-Leontiev approach. Scholars of St.-Petersburgtouch upon more specific issues using empirical methods, but still continue with nostalgia and hope making plans about creating a common concept of human individual according to Ananiev. Nowadays between the two schools there is no opposition, but only one mutual love.

Transcriptional activation of LON Gene by a new form of mitochondrial stress: A role for the nuclear respiratory factor 2 in StAR overload response (SOR).

Science.gov (United States)

Bahat, Assaf; Perlberg, Shira; Melamed-Book, Naomi; Isaac, Sara; Eden, Amir; Lauria, Ines; Langer, Thomas; Orly, Joseph

2015-06-15

High output of steroid hormone synthesis in steroidogenic cells of the adrenal cortex and the gonads requires the expression of the steroidogenic acute regulatory protein (StAR) that facilitates cholesterol mobilization to the mitochondrial inner membrane where the CYP11A1/P450scc enzyme complex converts the sterol to the first steroid. Earlier studies have shown that StAR is active while pausing on the cytosolic face of the outer mitochondrial membrane while subsequent import of the protein into the matrix terminates the cholesterol mobilization activity. Consequently, during repeated activity cycles, high level of post-active StAR accumulates in the mitochondrial matrix. To prevent functional damage due to such protein overload effect, StAR is degraded by a sequence of three to four ATP-dependent proteases of the mitochondria protein quality control system, including LON and the m-AAA membranous proteases AFG3L2 and SPG7/paraplegin. Furthermore, StAR expression in both peri-ovulatory ovarian cells, or under ectopic expression in cell line models, results in up to 3-fold enrichment of the mitochondrial proteases and their transcripts. We named this novel form of mitochondrial stress as StAR overload response (SOR). To better understand the SOR mechanism at the transcriptional level we analyzed first the unexplored properties of the proximal promoter of the LON gene. Our findings suggest that the human nuclear respiratory factor 2 (NRF-2), also known as GA binding protein (GABP), is responsible for 88% of the proximal promoter activity, including the observed increase of transcription in the presence of StAR. Further studies are expected to reveal if common transcriptional determinants coordinate the SOR induced transcription of all the genes encoding the SOR proteases. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

New FIGO and Swedish intrapartum cardiotocography classification systems incorporated in the fetal ECG ST analysis (STAN) interpretation algorithm: agreements and discrepancies in cardiotocography classification and evaluation of significant ST events.

Science.gov (United States)

Olofsson, Per; Norén, Håkan; Carlsson, Ann

2018-02-01

The updated intrapartum cardiotocography (CTG) classification system by FIGO in 2015 (FIGO2015) and the FIGO2015-approached classification by the Swedish Society of Obstetricians and Gynecologist in 2017 (SSOG2017) are not harmonized with the fetal ECG ST analysis (STAN) algorithm from 2007 (STAN2007). The study aimed to reveal homogeneity and agreement between the systems in classifying CTG and ST events, and relate them to maternal and perinatal outcomes. Among CTG traces with ST events, 100 traces originally classified as normal, 100 as suspicious and 100 as pathological were randomly selected from a STAN database and classified by two experts in consensus. Homogeneity and agreement statistics between the CTG classifications were performed. Maternal and perinatal outcomes were evaluated in cases with clinically hidden ST data (n = 151). A two-tailed p ST events, heterogeneities were significant and agreements moderate to almost perfect (STAN2007 vs. FIGO2015 0.86, 0.72; STAN2007 vs. SSOG2017 0.92, 0.84; FIGO2015 vs. SSOG2017 0.94, 0.87). Significant ST events occurred more often combined with STAN2007 than with FIGO2015 classification, but not with SSOG2017; correct identification of adverse outcomes was not significantly different between the systems. There are discrepancies in the classification of CTG patterns and significant ST events between the old and new systems. The clinical relevance of the findings remains to be shown. © 2017 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).

Development of Miocene-Pliocene reef trend, St. Croix, U. S. Virgin Islands

Energy Technology Data Exchange (ETDEWEB)

Gill, I.; Eby, D.E.; Hubbard, D.K.; Frost, S.H.

1988-01-01

The Miocene-Pliocene reef trend on St. Croix, U.S. Virgin Islands, rims the present southern western coasts of the island and includes accompanying lagoonal and forereef facies. The reef trend was established on a foram-algal bank facies that represents basinal shallowing from the deep-water pelagic and hemipelagic facies of the Miocene Kingshill Limestone. Information on facies distribution and thickness is derived from rock exposures and 22 test wells drilled to a maximum depth of 91 m. The greatest thickness of the reef facies exists in a subsidiary graben on the south coast of St. Croix. The thickness of the reef section in this locality is due to preservation of the section in a downdropped block. Reef faunas include extant corals, as well as several extinct genera. Extant corals (e.g. Montastrea annularis, Diploria sp., and Porites porites) and extinct corals (e.g., Stylophora affinis, Antillea bilobata, and Thysanus sp.) are the main reef frame-builders. Coralline algea and large benthic foraminifera are significant contributors to the sediments both prior to and during scleractinian reef growth. Dolomitization and calcite cementation occur prominantly in an area corresponding to a Holocene lagoon. The spatial distribution of the dolomite suggests that the lagoon is a Tertiary feature directly related to the dolomitization process. Stable isotopic values suggest dolomitization of fluids of elevated salinity.

NASA-UVA Light Aerospace Alloy and Structures Technology Program (LA2ST)

Science.gov (United States)

Gangloff, Richard P.; Starke, Edgar A., Jr.; Kelly, Robert G.; Scully, John R.; Shiflet, Gary J.; Stoner, Glenn E.; Wert, John A.

1997-01-01

The NASA-UVA Light Aerospace Alloy and Structures Technology (LA2ST) Program was initiated in 1986 and continues with a high level of activity. Here, we report on progress achieved between July I and December 31, 1996. The objective of the LA2ST Program is to conduct interdisciplinary graduate student research on the performance of next generation, light-weight aerospace alloys, composites and thermal gradient structures in collaboration with NASA-Langley researchers. Specific technical objectives are presented for each research project. We generally aim to produce relevant data and basic understanding of material mechanical response, environmental/corrosion behavior, and microstructure; new monolithic and composite alloys; advanced processing methods; new solid and fluid mechanics analyses; measurement and modeling advances; and a pool of educated graduate students for aerospace technologies. The accomplishments presented in this report are summarized as follows. Three research areas are being actively investigated, including: (1) Mechanical and Environmental Degradation Mechanisms in Advanced Light Metals, (2) Aerospace Materials Science, and (3) Mechanics of Materials for Light Aerospace Structures.

Diagnostic value for coronary artery disease of ST depression and chest pain during dipyridamole loading

International Nuclear Information System (INIS)

Yonezawa, Yoshihiro; Doi, Yoshinori; Aono, Tadashi; Odawara, Hiroaki; Chikamori, Taishiro; Yamada, Mitsutoshi; Takata, Jun; Ozawa, Toshio; Hamashige, Naohisa.

1991-01-01

The diagnostic significance of both ST depression and chest pain during dipyridamole loading was assessed in 437 patients with coronary artery disease (CRD) who have received dipyridamole-loading thallium-201 myocardial scintigraphy and coronary arteriography. ST depression and chest pain were induced in 35% and 42%, respectively. ST depression occurred in 23% for one vessel disease, 55% for two-vessel disease, 67% for three-vessel disease, and 11% for non-significant disease. In the absence of myocardial infarction, it occurred in as many as 78% for two-vessel disease and 94% for three-vessel disease. ST depression had a sensitivity of 51% and a specificity of 89%. Chest pain had a lower specificity (77%), whereas the sensitivity remained the same (51%). In 42 (31%) of 134 patients with ST depression, coronary revascularization was necessary in the early stage. With a median follow up of 29 months, 3 patients (2%) died of cardiac events, and 12 (9%) had nonfatal cardiac complications. There was a significant correlation between reversible defects (RD) on myocardial scintigrams and ST depression; RD were seen in 81% of ST depression cases, and ST depression occurred in 51% of 210 RD cases. The more diseased vessels, the more frequently ST depression occurred in accordance with RD on myocardial scintigrams. Both ST depression and chest pain during dipyridamole loading tended to be associated with myocardial ischemia, suggesting the diagnostic value in CRD patients with limited exercise loading. RD on myocardial scintigrams was considered attributable to coronary steal phenomenon for multi-vessel disease and to the difference in the relative increase of the coronary flow for single vessel disease. (N.K.)

21st Century Power Partnership: September 2016 Fellowship Report

Energy Technology Data Exchange (ETDEWEB)

Reber, Timothy J. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Rambau, Prudence [Eskom, Pretoria (South Africa); Mdhluli, Sipho [Eskom, Pretoria (South Africa)

2017-09-29

This report details the 21st Century Power Partnership fellowship from September 2016. This Fellowship is a follow-up to the Technical Audit of Eskom's Medium- and Long-term Modelling Capabilities, conducted by U.S. National Renewable Energy Laboratory (NREL) in April 2016. The prospect and role of variable renewable energy (vRE) in South Africa poses new modelling-related challenges that Eskom is actively working to address by improving the fidelity of PLEXOS LT and ST models.

Socioeconomic factors affecting infant sleep-related deaths in St. Louis.

Science.gov (United States)

Hogan, Cathy

2014-01-01

Though the Back to Sleep Campaign that began in 1994 caused an overall decrease in sudden infant death syndrome (SIDS) rates, racial disparity has continued to increase in St. Louis. Though researchers have analyzed and described various sociodemographic characteristics of SIDS and infant deaths by unintentional suffocation in St. Louis, they have not simultaneously controlled for contributory risk factors to racial disparity such as race, poverty, maternal education, and number of children born to each mother (parity). To determine whether there is a relationship between maternal socioeconomic factors and sleep-related infant death. This quantitative case-control study used secondary data collected by the Missouri Department of Health and Senior Services between 2005 and 2009. The sample includes matched birth/death certificates and living birth certificates of infants who were born/died within time frame. Descriptive analysis, Chi-square, and logistic regression. The controls were birth records of infants who lived more than 1 year. Chi-square and logistic regression analyses confirmed that race and poverty have significant relationships with infant sleep-related deaths. The social significance of this study is that the results may lead to population-specific modifications of prevention messages that will reduce infant sleep-related deaths. © 2013 Wiley Periodicals, Inc.

1st International Conference on Computational and Experimental Biomedical Sciences

CERN Document Server

Jorge, RM

2015-01-01

This book contains the full papers presented at ICCEBS 2013 – the 1st International Conference on Computational and Experimental Biomedical Sciences, which was organized in Azores, in October 2013. The included papers present and discuss new trends in those fields, using several methods and techniques, including active shape models, constitutive models, isogeometric elements, genetic algorithms, level sets, material models, neural networks, optimization, and the finite element method, in order to address more efficiently different and timely applications involving biofluids, computer simulation, computational biomechanics, image based diagnosis, image processing and analysis, image segmentation, image registration, scaffolds, simulation, and surgical planning. The main audience for this book consists of researchers, Ph.D students, and graduate students with multidisciplinary interests related to the areas of artificial intelligence, bioengineering, biology, biomechanics, computational fluid dynamics, comput...

Níveis de PCR são maiores em pacientes com síndrome coronariana aguda e supradesnivelamento do segmento ST do que em pacientes sem supradesnivelamento do segmento ST Niveles de PCR son mayores en pacientes con síndrome coronario agudo y supradesnivel del segmento ST que en pacientes sin supradesnivel del segmento ST CRP levels are higher in patients with ST elevation than non-ST elevation acute coronary syndrome

Directory of Open Access Journals (Sweden)

Syed Shahid Habib

2011-01-01

Full Text Available FUNDAMENTO: Há grande interesse no uso de proteína C-reativa de alta sensibilidade (PCR-as para avaliação de risco. Altos níveis de PCR-as no início da síndrome coronária aguda (SCA, antes da necrose tecidual, pode ser um marcador substituto para comorbidades cardiovasculares. OBJETIVO: Dessa forma, nosso objetivo foi estudar diferentes medidas de seguimento de níveis de PCR-as em pacientes com SCA e comparar as diferenças entre infarto do miocárdio sem elevação do segmento ST (NSTEMI com pacientes apresentando elevação do segmento ST (STEMI. MÉTODOS: Este é um estudo observacional. Dos 89 pacientes recrutados, 60 apresentavam infarto agudo do miocárdio (IAM. Três níveis seriados de PCR-us, a nível basal na hospitalização antes de 12 horas após inicio dos sintomas, níveis de pico 36-48 horas após hospitalização e níveis de acompanhamento após 4 a 6 semanas foram analisados e comparados entre pacientes com (IAMCSST e sem supradesnivelamento do segmento ST (IAMSSST. RESULTADOS: Pacientes com IAMCSST tinham IMC significantemente mais alta quando comparados com pacientes IAMSSST. Os níveis de creatino quinase fração MB (CK-MB e aspartato aminotransferase (AST eram significantemente mais altos em pacientes com IAMCSST quando comparados com pacientes com IAMSSST (pFUNDAMENTO: Hay gran interés en el uso de proteína C-reactiva de alta sensibilidad (PCR-as para evaluación de riesgo. Altos niveles de PCR-as en el comienzo del síndrome coronario agudo (SCA, antes de la necrosis tisular, puede ser un marcador sustituto para comorbilidades cardiovasculares. OBJETIVO: De esa forma, nuestro objetivo fue estudiar diferentes medidas de seguimiento de niveles de PCR-as en pacientes con SCA y comparar las diferencias entre infarto de miocardio sin elevación del segmento ST (NSTEMI con pacientes presentando elevación del segmento ST (STEMI. MÉTODOS: Este es un estudio observacional. De los 89 pacientes reclutados, 60

Training the 21st Century Voice Teacher: An Overview and Curriculum Survey of the Undergraduate Experience

Science.gov (United States)

Walz, Ivy

2014-01-01

This document examines the current status of voice teacher education in the 21st century, focusing on the undergraduate experience as an important first step, and links that experience to current trends in pedagogical training as a whole. This document includes the results of a curriculum survey detailing the undergraduate vocal pedagogy courses…

Education for Employment in Nigeria in the 21st Century: Some ...

African Journals Online (AJOL)

This paper examined education for employment in Nigeria in the 21st Century. This paper therefore looked at the demand of workplace employment skills, learning skills, literacy skills and life skills. This paper concludes by advocating how to teach 21st Century employment skills, how to guarantee gainful employment, and ...

Design assumptions and bases for small D-T-fueled Sperical Tokamak (ST) fusion core

International Nuclear Information System (INIS)

Peng, Y.K.M.; Galambos, J.D.; Fogarty, P.J.

1996-01-01

Recent progress in defining the assumptions and clarifying the bases for a small D-T-fueled ST fusion core are presented. The paper covers several issues in the physics of ST plasmas, the technology of neutral beam injection, the engineering design configuration, and the center leg material under intense neutron irradiation. This progress was driven by the exciting data from pioneering ST experiments, a heightened interest in proof-of-principle experiments at the MA level in plasma current, and the initiation of the first conceptual design study of the small ST fusion core. The needs recently identified for a restructured fusion energy sciences program have provided a timely impetus for examining the subject of this paper. Our results, though preliminary in nature, strengthen the case for the potential realism and attractiveness of the ST approach

Středisko volného času Kostka

OpenAIRE

Křenková, Romana

2017-01-01

Tématem diplomové práce je novostavba školního zařízení Střediska volného času Kostka. SVČ je samostatně stojící objekt na mírně svažitém pozemku, se dvěma nadzemními podlažími. Objekt není podsklepen. SVČ se nachází vedle mateřské školy a základní školy. Dispozičně zahrnuje objekt 11 učeben a je navržen pro 163 dětí. Obvodové, vnitřní nosné i nenosné stěny jsou navrženy z cihelných bloků. Stropy jsou tvořeny pomocí předpjatých stropních panelů. Objekt je zastřešen jednoplášťovou plochou stře...

A look at S&T Awareness - Enhancements in India

Directory of Open Access Journals (Sweden)

Chandra Mohan Nautiyal

2008-06-01

Full Text Available Basing mainly on author's direct involvement in some science communication efforts in India, and other reports, this contribution depicts and analyses the present science communication/ popularization scenario in India. It tries to dispel a myth that rural people don't require or don’t crave for S&T information. It discusses need for science and technology communication, sustaining curiosity and creating role models. Citing cases of some natural, 'unnatural' and organized events, it recounts how S&T popularization efforts have fared during the past decade and a half. It's made possible using print, AV and interactive media which, at times, require lot of financial inputs. However, this contribution shows that a number of natural and other phenomena can be used to convince people about power of S&T and in molding their attitude. The cases cited may be from India, but, with a little variation, are true for most of the developing and under- developed societies.

Lithium Resources for the 21st Century

Science.gov (United States)

Kesler, S.; Gruber, P.; Medina, P.; Keolian, G.; Everson, M. P.; Wallington, T.

2011-12-01

Lithium is an important industrial compound and the principal component of high energy-density batteries. Because it is the lightest solid element, these batteries are widely used in consumer electronics and are expected to be the basis for battery electric vehicles (BEVs), hybrid electric vehicles (HEVs) and plug-in hybrid electric vehicles (PHEVs) for the 21st century. In view of the large incremental demand for lithium that will result from expanded use of various types of EVs, long-term estimates of lithium demand and supply are advisable. For GDP growth rates of 2 to 3% and battery recycling rates of 90 to 100%, total demand for lithium for all markets is expected to be a maximum of 19.6 million tonnes through 2100. This includes 3.2 million tonnes for industrial compounds, 3.6 million tonnes for consumer electronics, and 12.8 million tonnes for EVs. Lithium-bearing mineral deposits that might supply this demand contain an estimated resource of approximately 39 million tonnes, although many of these deposits have not been adequately evaluated. These lithium-bearing mineral deposits are of two main types, non-marine playa-brine deposits and igneous deposits. Playa-brine deposits have the greatest immediate resource potential (estimated at 66% of global resources) and include the Salar de Atacama (Chile), the source of almost half of current world lithium production, as well as Zabuye (China/Tibet) and Hombre Muerto (Argentina). Additional important playa-brine lithium resources include Rincon (Argentina), Qaidam (China), Silver Peak (USA) and Uyuni (Bolivia), which together account for about 35% of the estimated global lithium resource. Information on the size and continuity of brine-bearing aquifers in many of these deposits is limited, and differences in chemical composition of brines from deposit to deposit require different extraction processes and yield different product mixes of lithium, boron, potassium and other elements. Numerous other brines in playas

Severe Hyperthyroidism Presenting with Acute ST Segment Elevation Myocardial Infarction

Directory of Open Access Journals (Sweden)

Dayan Zhou

2015-01-01

Full Text Available Introduction. Acute myocardial infarction is life-threatening. A cardiac troponin rise accompanied by typical symptoms, ST elevation or depression is diagnostic of acute myocardial infarction. Here, we report an unusual case of a female who was admitted with chest pain. However, she did not present with a typical profile of an acute myocardial infarction patient. Case Presentation. A 66-year-old Han nationality female presented with chest pain. The electrocardiogram (ECG revealed arched ST segment elevations and troponin was elevated. However, the coronary angiography showed a normal coronary arterial system. Thyroid function tests showed that this patient had severe hyperthyroidism. Conclusion. Our case highlights the possibility that hyperthyroidism may cause a large area of myocardium injury and ECG ST segment elevation. We suggest routine thyroid function testing in patients with chest pain.

An audit of the management of diabetic ketoacidosis at St Luke’s Hospital

OpenAIRE

Abela, Alexia-Giovanna; Magri, Caroline Jane; Debono, Miguel; Calleja, Neville; Vassallo, Josanne; Azzopardi, Joseph;

2008-01-01

Aim: To perform an audit of the protocol used in the management of patients with Diabetic Ketoacidosis, in St Lukes Hospital. Methods: Patients admitted with `Diabetes Ketoacidosis', between 14th August 2004 and 14th August 2005, were identified from the Admission book at the Accident and Emergency Department. Data obtained from patients' medical records were collected according to a preset proforma. The criteria assessed by this audit included parameter monitoring, investigations performed, ...

Industrializing the near-earth asteroids: Speculations on human activities in space in the latter half of the 21st century

Science.gov (United States)

Sercel, Joel C.

1990-01-01

The use of solar system resources for human industry can be viewed as a natural extension of the continual growth of our species' habitat. Motivations for human activities in space can be discussed in terms of five distinct areas: (1) information processing and collection; (2) materials processing; (3) energy production to meet terrestrial power needs; (4) the use of extraterrestrial materials; and (5) disaster avoidance. When considering 21st-Century activities in space, each of these basic motivations must be treated in light of issues likely to be relevant to the 21st-Century earth. Many of the problems facing 21st-Century earth may stem from the need to maintain the world population of 8 to 10 billion people as is projected from expected growth rates. These problems are likely to include managing the impact of industrial processes on the terrestrial biosphere while providing adequate energy production and material goods for the growing population. The most important human activities in space in the latter half of the 21st Century may be associated with harnessing the resources of the near-earth asteroids for industrial processes. These above topics are discussed with an emphasis on space industrialization.

St. Laurent Construction Co., Inc. Information Sheet

Science.gov (United States)

St. Laurent Construction Co., Inc. (the Company) is located in Nashua, New Hampshire. The settlement involves renovation activities conducted at properties constructed prior to 1978, located in Merrimack and Nashua, New Hampshire.

Minimal pneumothorax with dynamic changes in ST segment similar to myocardial infarction.

Science.gov (United States)

Yeom, Seok-Ran; Park, Sung-Wook; Kim, Young-Dae; Ahn, Byung-Jae; Ahn, Jin-Hee; Wang, Il-Jae

2017-08-01

Pneumothorax can cause a variety of electrocardiographic changes. ST segment elevation, which is mainly observed in myocardial infarction, can also be induced by pneumothorax. The mechanism is presumed to be a decrease in cardiac output, due to increased intra-thoracic pressure. We encountered a patient with ST segment elevation with minimal pneumothorax. Coronary angiography with ergonovine provocation test and echocardiogram had normal findings. The ST segment elevation was normalized by decreasing the amount of pneumothorax. We reviewed the literature and present possible mechanisms for this condition. Copyright © 2017 Elsevier Inc. All rights reserved.

Adult Enrichment Learners in St. Cloud, Minnesota: Motivational Reasons for Participation

Science.gov (United States)

Wallner, Scott David

2012-01-01

The purpose of the study was to identify reasons and motivation of adult stakeholders that influence participation in adult community education enrichment classes in the St. Cloud Public School District, St. Cloud, Minnesota. The study also examined the perceptions about adult learners held by leaders, planners, and facilitators of these programs,…

The effect of porcine somatotropin (pST) and gender on production ...

African Journals Online (AJOL)