Improved functionality, health related quality of life and decreased burden of disease in patients with ADHD treated with OROS® MPH: is treatment response different between children and adolescents?

Directory of Open Access Journals (Sweden)

Rettig Klaus

2011-07-01

Full Text Available Abstract Background To compare clinical and health-related quality of life (HRQoL outcomes between children and adolescents with ADHD treated with OROS® MPH, using data from two large similarly-designed multicenter, prospective, open-label, single-arm, non-interventional studies. Methods Pooled analysis (42603ATT4037, 42603 - ATT - 4001 including patients (6 to 18 years with a confirmed diagnosis of ADHD. Patients were treated with OROS® MPH for 12 weeks; ADHD symptoms, functioning, HRQoL, safety and tolerability parameters were assessed. Results 822 patients (583 children [6-12 years], 239 adolescents [13-18 years] were included in the pooled analysis. Mean daily OROS® MPH starting doses in the child and adolescent subgroups were 29.0 ± 11.7 and 37.6 ± 15.6 mg, respectively (p ® MPH in 76.9%, 86.0% and 79.3% of children, adolescents and the total population, respectively, at study end (p = 0.029 between-age subgroups. 195 of 822 patients (23.7% experienced at least one treatment-emergent adverse event; most commonly reported AEs in the total group (≥4% were insomnia (7.2%, anorexia (4.3% and involuntary muscle contractions (4.1%. No clinically relevant changes in body weight or vital signs were observed. Conclusions Clinically relevant differences between children and adolescents with ADHD are present. Adolescents appeared to have a lower health related quality of life and functioning compared to children at baseline, however, they were able to reach comparable ratings at endpoint for most items. Similarly, burden of disease decreased in patients and their carers. OROS MPH was generally safe and well tolerated.

[The utility of a continuous performance test embedded in virtual reality in measuring the effectiveness of MPH treatment in boys with ADHD].

Science.gov (United States)

Shriki, Liron; Weizer, Merav; Pollak, Yehuda; Weiss, Patricia L; Rizzo, Albert A; Gross-Tsur, Varda

2010-01-01

Continuous performance tasks (CPT) are popular in the diagnostic process of attention deficit hyperactivity disorder (ADHD), providing an objective measure of attention for a disorder with otherwise subjective criteria. The study aimed to: 1) examine whether the VR-CPT is sensitive to methylphenidate (MPH); 2) assess how the virtual reality (VR) environment is experienced. Twenty boys, 9-17 years, with ADHD underwent 3 CPTs: VR-CPT, the same CPT without VR (no VR-CPT) and the Test of Variables of Attention (T.O.V.A.). Subsequently, those with ADHD repeated the tests 1 hour following MPH ingestion. Immediately following the CPT, the subjects described their subjective experiences on the Short Feedback Questionnaire. Results were analyzed using ANOVA with repeated measures. MPH reduced the omission and commission errors on all tests to a similar degree. Subjective feelings of enjoyment were most positive for VR-CPT. The VR-CPT is a sensitive and user-friendly assessment tool for evaluating the effectiveness of MPH treatment in boys with ADHD.

Six-month effects of the Groningen active living model (GALM) on physical activity, health and fitness outcomes in sedentary and underactive older adults aged 55-65

NARCIS (Netherlands)

de Jong, Johan; Lemmink, Koen A. P. M.; Stevens, Martin; de Greef, Mathieu H. G.; Rispens, Pieter; King, Abby C.; Mulder, Theo

Objective: To determine the effects on energy expenditure, health and fitness outcomes in sedentary older adults aged 55-65 after 6-month participation in the GALM program. Methods: In three Dutch communities, subjects from matched neighbourhoods were assigned to an intervention (n = 79) or a

Inficon Transpector MPH Mass Spectrometer Random Vibration Test Report

Science.gov (United States)

Santiago-Bond, Jo; Captain, Janine

2015-01-01

The purpose of this test report is to summarize results from the vibration testing of the INFICON Transpector MPH100M model Mass Spectrometer. It also identifies requirements satisfied, and procedures used in the test. As a payload of Resource Prospector, it is necessary to determine the survivability of the mass spectrometer to proto-qualification level random vibration. Changes in sensitivity of the mass spectrometer can be interpreted as a change in alignment of the instrument. The results of this test will be used to determine any necessary design changes as the team moves forward with flight design.

Six-month effects of the Groningen active living model (GALM) on physical activity, health and fitness outcomes in sedentary and underactive older adults aged 55–65

NARCIS (Netherlands)

de Jong, Johan; Lemmink, Koen; Stevens, Martin; de Greef, Mathieu; Rispens, Piet; King, Abby C.; Mulder, Theo

2006-01-01

Objective: To determine the effects on energy expenditure, health and fitness outcomes in sedentary older adults aged 55–65 after 6-month participation in the GALM program. Methods: In three Dutch communities, subjects from matched neighbourhoods were assigned to an intervention (n = 79) or a

Innovating in health care management education: development of an accelerated MBA and MPH degree program at Yale.

Science.gov (United States)

Pettigrew, Melinda M; Forman, Howard P; Pistell, Anne F; Nembhard, Ingrid M

2015-03-01

Increasingly, there is recognition of the need for individuals with expertise in both management and public health to help health care organizations deliver high-quality and cost-effective care. The Yale School of Public Health and Yale School of Management began offering an accelerated Master of Business Administration (MBA) and Master of Public Health (MPH) joint degree program in the summer of 2014. This new program enables students to earn MBA and MPH degrees simultaneously from 2 fully accredited schools in 22 months. Students will graduate with the knowledge and skills needed to become innovative leaders of health care organizations. We discuss the rationale for the program, the developmental process, the curriculum, benefits of the program, and potential challenges.

Materials at 200 mph: Making NASCAR Faster and Safer

Science.gov (United States)

Leslie-Pelecky, Diandra

2008-03-01

You cannot win a NASCAR race without understanding science.ootnotetextDiandra Leslie-Pelecky, The Physics of NASCAR (Dutton, New York City, 2008). Materials play important roles in improving performance, as well as ensuring safety. On the performance side, NASCAR limits the materials race car scientists and engineers can use to limit ownership costs. `Exotic metals' are not allowed, so controlling microstructure and nanostructure are important tools. Compacted Graphite Iron, a cast iron in which magnesium additions produce interlocking microscale graphite reinforcements, makes engine blocks stronger and lighter. NASCAR's new car design employs a composite called Tegris^TM that has 70 percent of the strength of carbon fiber composites at about 10 percent of the cost. The most important role of materials in racing is safety. Drivers wear firesuits made of polymers that carbonize (providing thermal protection) and expand (reducing oxygen access) when heated. Catalytic materials originally developed for space-based CO2 lasers filter air for drivers during races. Although materials help cars go fast, they also help cars slow down safely---important because the kinetic energy of a race car going 180 mph is nine times greater than that of a passenger car going 60 mph. Energy-absorbing foams in the cars and on the tracks control energy dissipation during accidents. To say that most NASCAR fans (and there are estimated to be 75 million of them) are passionate about their sport is an understatement. NASCAR fans understand that science and engineering are integral to keeping their drivers safe and helping their teams win. Their passion for racing gives us a great opportunity to share our passion for science with them. NASCAR^ is a registered trademark of the National Association for Stock Car Auto Racing, Inc. Tegris^TM is a trademark of Milliken & Company.

Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor

DEFF Research Database (Denmark)

Owczarek, Sylwia; Kiryushko, Darya; Hald Larsen, Marianne

2010-01-01

Neuroplastin (Np) is a glycoprotein belonging to the immunoglobulin superfamily of cell adhesion molecules (CAMs) and existing in two isoforms, Np55 and Np65, named according to their molecular weights. The extracellular part of Np65 contains three immunoglobulin (Ig)-like modules (Ig1, Ig2, and Ig......3), whereas Np55 lacks the Ig1 module. Of these two isoforms, only Np65 is involved in homophilic interactions resulting in cell adhesion, whereas the role of Np55 is poorly understood. The present study reports for the first time the crystal structure of the ectodomain of Np55 at 1.95-A resolution...

Innovating in Health Care Management Education: Development of an Accelerated MBA and MPH Degree Program at Yale

Science.gov (United States)

Forman, Howard P.; Pistell, Anne F.; Nembhard, Ingrid M.

2015-01-01

Increasingly, there is recognition of the need for individuals with expertise in both management and public health to help health care organizations deliver high-quality and cost-effective care. The Yale School of Public Health and Yale School of Management began offering an accelerated Master of Business Administration (MBA) and Master of Public Health (MPH) joint degree program in the summer of 2014. This new program enables students to earn MBA and MPH degrees simultaneously from 2 fully accredited schools in 22 months. Students will graduate with the knowledge and skills needed to become innovative leaders of health care organizations. We discuss the rationale for the program, the developmental process, the curriculum, benefits of the program, and potential challenges. PMID:25706023

Effect Of Platooning on Fuel Consumption of Class 8 Vehicles Over a Range of Speeds, Following Distances, and Mass

Energy Technology Data Exchange (ETDEWEB)

Lammert, M. P.; Duran, A.; Diez, J.; Burton, K.; Nicholson, A.

2014-10-01

This research project evaluates fuel consumption results of two Class 8 tractor-trailer combinations platooned together compared to their standalone fuel consumption. A series of ten modified SAE Type II J1321 fuel consumption track tests were performed to document fuel consumption of two platooned vehicles and a control vehicle at varying steady-state speeds, following distances, and gross vehicle weights (GVWs). The steady-state speeds ranged from 55 mph to 70 mph, the following distances ranged from a 20-ft following distance to a 75-ft following distance, and the GVWs were 65K lbs and 80K lbs. All tractors involved had U.S. Environmental Protection Agency (EPA) SmartWay-compliant aerodynamics packages installed, and the trailers were equipped with side skirts. Effects of vehicle speed, following distance, and GVW on fuel consumption were observed and analyzed. The platooning demonstration system used in this study consisted of radar systems, Dedicated Short-Range Communication (DSRC) vehicle-to-vehicle (V2V) communications, vehicle braking and torque control interface, cameras and driver displays. The lead tractor consistently demonstrated an improvement in average fuel consumption reduction as following distance decreased, with results showing 2.7% to 5.3% fuel savings at a GVW of 65k. The trailing vehicle achieved fuel consumption savings ranging from 2.8% to 9.7%; tests during which the engine cooling fan did not operate achieved savings of 8.4% to 9.7%. 'Team' fuel savings, considering the platooned vehicles as one, ranged from 3.7% to 6.4%, with the best combined result being for 55 mph, 30-ft following distance, and 65k GVW.

14 CFR 65.55 - Knowledge requirements.

Science.gov (United States)

2010-01-01

...; (12) Aeronautical decision making and judgment; and (13) Crew resource management, including crew communication and coordination. (b) The applicant must present documentary evidence satisfactory to the...

Risk factors associated with bus accident severity in the United States: A generalized ordered logit model

DEFF Research Database (Denmark)

Kaplan, Sigal; Prato, Carlo Giacomo

2012-01-01

of 2011. Method: The current study investigates the underlying risk factors of bus accident severity in the United States by estimating a generalized ordered logit model. Data for the analysis are retrieved from the General Estimates System (GES) database for the years 2005–2009. Results: Results show...... that accident severity increases: (i) for young bus drivers under the age of 25; (ii) for drivers beyond the age of 55, and most prominently for drivers over 65 years old; (iii) for female drivers; (iv) for very high (over 65 mph) and very low (under 20 mph) speed limits; (v) at intersections; (vi) because......Introduction: Recent years have witnessed a growing interest in improving bus safety operations worldwide. While in the United States buses are considered relatively safe, the number of bus accidents is far from being negligible, triggering the introduction of the Motor-coach Enhanced Safety Act...

Effects of MPH-OROS on the Organizational, Time Management, and Planning Behaviors of Children with ADHD

Science.gov (United States)

Abikoff, Howard; Nissley-Tsiopinis, Jenelle; Gallagher, Richard; Zambenedetti, Maurizio; Seyffert, Michael; Boorady, Roy; McCarthy, John

2009-01-01

A double-blind, placebo-controlled, crossover design study was done to evaluate the effects of methylphenidate-osmotic-release oral systems (MPH-OROS) on the organization, time management, and planning (OTMP) of children with attention deficit hyperactivity disorder (ADHD). Results show significant improvements on the OTMP of children with ADHD in…

Teaching Note--Educating Public Health Social Work Professionals: Results from an MSW/MPH Program Outcomes Study

Science.gov (United States)

Ruth, Betty J.; Marshall, Jamie Wyatt; Velásquez, Esther E. M.; Bachman, Sara S.

2015-01-01

Dual-degree programs in public health and social work continue to proliferate, yet there has been little research on master's of social work (MSW)/master's of public health (MPH) graduates. The purpose of this study was to describe and better understand the self-reported professional experiences, identities, roles, and outcomes associated with 1…

Must patients over 65 be haemodialysed?

Science.gov (United States)

Rotellar, E; Lubelza, R A; Rotellar, C; Martinez-Camps, E; Alea, M V; Valls, R

1985-01-01

This manuscript consists of a study of the results of 26 end stage renal failure (ESRF) patients, who commenced regular haemodialysis treatment (RHDT) from the age of 65 onwards (65-85) and who have been undergoing this treatment for periods ranging from 7 years to 3 months. These results are to be compared with those obtained from another group of 26 patients whose age ranged between 40 and 55 and who were treated with the same policy. The following parameters are compared: mortality, morbidity, life-style, cardiovascular situation, hypotension in haemodialysis, vascular access, anaemia, osteoarticular and peripheral nervous disorders, hypertension. We have not found any significant differences between both groups, besides a higher morbidity for patients over 65. Therefore, we recommend the inclusion of the older patients into RHDT programmes.

Including Adulthood in Music Education Perspectives and Policy: A Lifespan View

Science.gov (United States)

Myers, David E.

2012-01-01

Music learning among adults is witnessing rapid escalation as an important area of research and practice among music education professionals. In contrast to the years encompassed by childhood and adolescence, a significant challenge in teaching adults is that average life expectancies in developed countries include some 55 to 65 years beyond age…

Measurement of {sup 27}Al(γ,2pn){sup 24}Na Reaction Cross-sections with 55 -, 60 -, 65 - MeV Bremsstrahlung Employing MCNPX Simulation

Energy Technology Data Exchange (ETDEWEB)

Shin, S. G.; Kye, Y.; Cho, M. H. [POSTECH, Pohang (Korea, Republic of); Namkung, W. [Pohang Accelerator Laboratory, Pohang (Korea, Republic of); KIm, G. N.; Kim, K. [Kyungpook National Univ., Daegu (Korea, Republic of); Lee, M. W.; Kang, Y. R. [Dongnam Inst. Of Radiological and Medical Science, Busan (Korea, Republic of)

2014-05-15

Aluminum is used for monitoring the photon flux. The photon flux during the activation can be measured by substituting the {sup 27}Al(γ,2pn){sup 24}Na reaction cross-section induced by bremsstrahlung to reactivity equation. Therefore, if this cross-section is more accurate, gamma-ray flux can be measure more accurately. In this work, the {sup 27}Al(γ,2pn){sup 24}Na reaction cross-sections induced by 55 - 65 MeV bremsstrahlung were measured by activation technique at the Pohang Neutron Facility (PNF) which has produced the nuclear data using Time-Of-Flight method and activation technique. In order to get the photon flux, MCNPX was used. These measurement values were compared with the data of Meyer et al (1968)

Effect of Weight and Roadway Grade on the Fuel Economy of Class-8 Frieght Trucks

Energy Technology Data Exchange (ETDEWEB)

Franzese, Oscar [ORNL; Davidson, Diane [ORNL

2011-11-01

In 2006-08, the Oak Ridge National Laboratory, in collaboration with several industry partners, collected real-world performance and situational data for long-haul operations of Class-8 trucks from a fleet engaged in normal freight operations. Such data and information are useful to support Class-8 modeling of combination truck performance, technology evaluation efforts for energy efficiency, and to provide a means of accounting for real-world driving performance within combination truck research and analyses. The present study used the real-world information collected in that project to analyze the effects that vehicle speed and vehicle weight have on the fuel efficiency of Class-8 trucks. The analysis focused on two type of terrains, flat (roadway grades ranging from -1% to 1%) and mild uphill terrains (roadway grades ranging from 1% to 3%), which together covered more than 70% of the miles logged in the 2006-08 project (note: almost 2/3 of the distance traveled on mild uphill terrains was on terrains with 1% to 2% grades). In the flat-terrain case, the results of the study showed that for light and medium loads, fuel efficiency decreases considerably as speed increases. For medium-heavy and heavy loads (total vehicle weight larger than 65,000 lb), fuel efficiency tends to increase as the vehicle speed increases from 55 mph up to about 58-60 mph. For speeds higher than 60 mph, fuel efficiency decreases at an almost constant rate with increasing speed. At any given speed, fuel efficiency decreases and vehicle weight increases, although the relationship between fuel efficiency and vehicle weight is not linear, especially for vehicle weights above 65,000 lb. The analysis of the information collected while the vehicles were traveling on mild upslope terrains showed that the fuel efficiency of Class-8 trucks decreases abruptly with vehicle weight ranging from light loads up to medium-heavy loads. After that, increases in the vehicle weight only decrease fuel

A multicenter, open-label trial to evaluate the quality of life in adults with ADHD treated with long-acting methylphenidate (OROS MPH): Concerta Quality of Life (CONQoL) study.

Science.gov (United States)

Mattos, Paulo; Louzã, Mário Rodrigues; Palmini, André Luís Fernandes; de Oliveira, Irismar Reis; Rocha, Fábio Lopes

2013-07-01

The available literature provides few studies on the effectiveness of methylphenidate in improving quality of life in individuals with ADHD. To assess the effectiveness of methylphenidate OROS formulation (OROS MPH) through QoL in adults with ADHD. A 12-week, multicenter, open-label trial involving 60 patients was used. The measures used were Adult Self-Rating Scale, Adult ADHD Quality of Life Scale (AAQoL), State and Trait Anxiety Inventory (STAI), Hamilton Depression Rating Scale (HAM-D), Clinical Global Impression (CGI), and safety measures. A significance statistic level of 5% was adopted. Analyses included 60 patients (66.7% male; M age = 31.1 years) for safety and 58 patients for effectiveness. All AAQoL subscales improved from baseline to Week 12 (p < .0001), as well as the Total AAQoL (p < .0001). A significant reduction on Clinical Global Impression-Improvement (CGI-I), HAM-D, STAI, and ASRS scores was observed (p < .0001). No serious adverse event was reported. Treatment of adult ADHD patients with OROS MPH improves QoL.

45 MPH 6,000-Pound and 10,000-Pound Rough Terrain Fork Lift Truck Feasibility Study.

Science.gov (United States)

1986-06-24

Airport Post Office Box 66911 Chicago, IL 60666 NPN Security Classification of This Page REPORT DOCUMENTATION PAGE la . Report Security Classification...HOP Unausended Duadin., 20 - I: - 1 1.8 Inch RMS Road 14 la -3 * Clam C (0.93 Inch RMS) Rod w 12 10 10 Per~cent 9 P 7 U. 3 Percent 3 2 0 20 40 SPM...elm 10 67- * * 3 o *" - .2 0 20 40 W (mph) 4/2/ SOJA Figure 75. Rear Wheel Hop on Four Road Surfaces (10K RTFLT Unsuspended Baseline) " Page 93 Adding

Methylphenidate misuse in adult patients and the impact of therapeutic use

DEFF Research Database (Denmark)

Jensen, L S; Pagsberg, Anne Katrine; Dalhoff, Kim

2015-01-01

OBJECTIVE: Methylphenidate (MPH) prescription rates for adults increase, but the extent of a parallel rise in toxic exposures and their causes and distribution between different MPH trade names are unexplored. METHOD: We retrospectively analyzed adult MPH exposures reported to the Danish Poison...... Information Centre from January 2006 to July 2012 and the association with MPH sales and the number of patients prescribed MPH. RESULTS: Of the 394 exposures (57% males, median age 27 years) reported, MPH status was available in 249 of whom 65.5% were prescribed MPH. Exposure was in 54% motivated by suicidal...... (particularly Ritalin(®)/Ritalin(®) Uno). Most exposures were intentional and motivated by suicide attempts or recreational use....

40 CFR 65.65 - Monitoring.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Monitoring. 65.65 Section 65.65 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Process Vents § 65.65 Monitoring. (a) An owner or operator of a Group 2A process vent...

Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction

Directory of Open Access Journals (Sweden)

Lukas P. Feilen

2017-05-01

Full Text Available Physiological function and pathology of the Alzheimer’s disease causing amyloid precursor protein (APP are correlated with its cytosolic adaptor Fe65 encompassing a WW and two phosphotyrosine-binding domains (PTBs. The C-terminal Fe65-PTB2 binds a large portion of the APP intracellular domain (AICD including the GYENPTY internalization sequence fingerprint. AICD binding to Fe65-PTB2 opens an intra-molecular interaction causing a structural change and altering Fe65 activity. Here we show that in the absence of the AICD, Fe65-PTB2 forms a homodimer in solution and determine its crystal structure at 2.6 Å resolution. Dimerization involves the unwinding of a C-terminal α-helix that mimics binding of the AICD internalization sequence, thus shielding the hydrophobic binding pocket. Specific dimer formation is validated by nuclear magnetic resonance (NMR techniques and cell-based analyses reveal that Fe65-PTB2 together with the WW domain are necessary and sufficient for dimerization. Together, our data demonstrate that Fe65 dimerizes via its APP interaction site, suggesting that besides intra- also intermolecular interactions between Fe65 molecules contribute to homeostatic regulation of APP mediated signaling.

Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction.

Science.gov (United States)

Feilen, Lukas P; Haubrich, Kevin; Strecker, Paul; Probst, Sabine; Eggert, Simone; Stier, Gunter; Sinning, Irmgard; Konietzko, Uwe; Kins, Stefan; Simon, Bernd; Wild, Klemens

2017-01-01

Physiological function and pathology of the Alzheimer's disease causing amyloid precursor protein (APP) are correlated with its cytosolic adaptor Fe65 encompassing a WW and two phosphotyrosine-binding domains (PTBs). The C-terminal Fe65-PTB2 binds a large portion of the APP intracellular domain (AICD) including the GYENPTY internalization sequence fingerprint. AICD binding to Fe65-PTB2 opens an intra-molecular interaction causing a structural change and altering Fe65 activity. Here we show that in the absence of the AICD, Fe65-PTB2 forms a homodimer in solution and determine its crystal structure at 2.6 Å resolution. Dimerization involves the unwinding of a C-terminal α-helix that mimics binding of the AICD internalization sequence, thus shielding the hydrophobic binding pocket. Specific dimer formation is validated by nuclear magnetic resonance (NMR) techniques and cell-based analyses reveal that Fe65-PTB2 together with the WW domain are necessary and sufficient for dimerization. Together, our data demonstrate that Fe65 dimerizes via its APP interaction site, suggesting that besides intra- also intermolecular interactions between Fe65 molecules contribute to homeostatic regulation of APP mediated signaling.

47 CFR 65.105 - Discovery.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Discovery. 65.105 Section 65.105... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Procedures § 65.105 Discovery. (a) Participants... evidence. (c) Discovery requests pursuant to § 65.105(b), including written interrogatories, shall be filed...

Science Library of Test Items. Volume Thirteen. Mastery Testing Program. [Mastery Tests Series 5.] Tests M51-M65.

Science.gov (United States)

New South Wales Dept. of Education, Sydney (Australia).

As part of a series of tests to measure mastery of specific skills in the natural sciences, copies of tests 51 through 65 include: (51) interpreting atomic and mass numbers; (52) extrapolating from a geological map; (53) matching geological sections and maps; (54) identifying parts of the human eye; (55) identifying the functions of parts of a…

Studies on the concentrations of 55Fe in South Pacific Ocean water and marine organisms and in the Columbia River. Progress report, July 1, 1976--June 30, 1977

International Nuclear Information System (INIS)

Jennings, C.D.

1977-01-01

Progress is reported on studies of processes controlling the distribution of 55 Fe in the Columbia River ecosystem and in the Pacific Ocean. Iron-55 was found to be a unique tracer for particulate setting in the ocean. Data are included on the content of 55 Fe in Columbia River sediments and in samples of seawater and marine organisms collected at various depths from locations in the South Pacific Ocean. The highest concentrations were found in crustaceans and fishes from the mesopelogic and epipelozic zones. A biological model of 55 Fe distribution in fish was developed based on measurements of 55 Fe and 65 Zn in carp caught in the Columbia River

Comparative acute efficacy and tolerability of OROS and immediate release formulations of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder

Directory of Open Access Journals (Sweden)

Hammerness Paul

2007-09-01

Full Text Available Abstract Background The main aim of this study was to compare the safety and efficacy of IR MPH administered three times daily to those of once daily OROS-MPH. Methods Subjects were outpatient adults satisfying full diagnostic criteria for DSM-IV ADHD between 19 and 60 years of age. Data from two independently conducted 6-week placebo controlled, randomized clinical trials of IR-MPH (tid and of OROS-MPH were pooled to create three study groups: Placebo (N = 116, IR-MPH (tid (N = 102 and OROS-MPH (N = 67. Results Eight-five percent (N = 99 of placebo treated subjects, 77% (N = 79 of the IR-MPH (tid treated subjects, and 82% (N = 55 of the OROS-MPH treated subjects completed the 6-week trial. Total daily doses at endpoint were 80.9 ± 31.9 mg, 74.8 ± 26.2 mg, and 95.4 ± 26.3 mg in the OROS-MPH, IR-MPH (tid, and placebo groups, respectively. At endpoint, 66% (N = 44 of subjects receiving OROS-MPH and 70% (N = 71 of subjects receiving IR-MPH (tid were considered responders compared with 31% (N = 36 on placebo. Conclusion Comparison of data from two similarly designed, large, randomized, placebo-controlled, trials, showed that equipotent daily doses of once daily OROS-MPH had similar efficacy to that of TID administered IR MPH. Trial Registration The trial of OROS-MPH was registered at clinicaltrials.gov, number NCT00181571.

Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma and its application to pharmacokinetic study.

Science.gov (United States)

Zhang, Chenghao; Luo, Huafei; Wu, Yubo; Zhang, Junyun; Zhang, Furong; Lin, Guobei; Wang, Hao

2016-02-01

A chiral UFLC-MS/MS method was established and validated for quantifying d-threo-methylphenidate (d-threo-MPH), l-threo-methylphenidate (l-threo-MPH), d-threo-ethylphenidate (d-threo-EPH), l-threo-ethylphenidate (l-threo-EPH) and d,l-threo-ritalinic acid (d,l-threo-RA) in rat plasma over the linearity range of 1-500ng/mL. Chiral separation was performed on an Astec Chirobiotic V2 column (5μm, 250×2.1mm) with isocratic elution using methanol containing 0.003% ammonium acetate (w/v) and 0.003% trifluoroacetic acid (v/v) at a flow of 0.3mL/min. All analytes and IS were extracted from rat plasma by a one-step liquid-liquid extraction (LLE) method. The intra- and inter-run accuracies were within 85-115%, and the intra- and inter-run precision were <10% for all analytes. Extraction recoveries were 55-62% for d-threo-MPH, 54-60% for l-threo-MPH, 55-60% for d-threo-EPH, 53-57% for l-threo-EPH and 25-30% for d,l-threo-RA. The validated UFLC-MS/MS method successfully applied to the pharmacokinetic interaction study of oral d-threo-MPH and l-threo-MPH (alone or in combination) in female Sprague Dawley rats. The EPH was not detected in rat plasma following oral administrated MPH without EtOH. As far as it is known to the authors, this study is the first one step liquid-liquid extraction method to extract and UFLC-MS/MS method to quantify d-threo-MPH, l-threo-MPH, d-threo-EPH, l-threo-EPH and d,l-threo-RA simultaneously. Copyright © 2015 Elsevier B.V. All rights reserved.

FS65 Disposition Option Report

Energy Technology Data Exchange (ETDEWEB)

Wenz, Tracy R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2015-09-25

This report outlines the options for dispositioning the MOX fuel stored in FS65 containers at LANL. Additional discussion regarding the support equipment for loading and unloading the FS65 transport containers is included at the end of the report.

21 CFR 1240.65 - Psittacine birds.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Psittacine birds. 1240.65 Section 1240.65 Food and... DISEASES Specific Administrative Decisions Regarding Interstate Shipments § 1240.65 Psittacine birds. (a) The term psittacine birds shall include all birds commonly known as parrots, Amazons, Mexican double...

75 FR 16391 - Limiting the Use of Wireless Communication Devices

Science.gov (United States)

2010-04-01

... the purpose of snow/ice removal; and persons operating a CMV for emergency response activities (all of... of the FRA's Emergency Order No. 26 regarding restricting distracting electronic devices (see... length of a football field, including the end zones, without looking at the roadway. At 65 mph (or 95.3...

43 CFR 12.65 - Program income.

Science.gov (United States)

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Program income. 12.65 Section 12.65 Public... to State and Local Governments Post-Award Requirements § 12.65 Program income. (a) General. Grantees are encouraged to earn income to defray program costs. Program income includes income from fees for...

A Comparison of 2 Current-Issue Army Boots, 5 Prototype Military Boots, and 5 Commercial Hiking Boots: Performance, Efficiency, Biomechanics, Comfort and Injury

Science.gov (United States)

1999-11-01

Maximum force (N) on the ankle, knee and hip while walking at 3.5 mph 51 23. Maximum heel- strike force (N) while walking at 3.5 mph ^.ർ 24...to first force peak while running at 6.5 mph ’.""."..62 34. Variables relating to force low point between the heel- strike and push-off peak...was lower peak deceleration and lower peak pressure at the heel than at the forefoot . In the second phase of their research, Hamill and Bensel (7, 8

28 CFR 55.3 - Statutory requirements.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Statutory requirements. 55.3 Section 55.3 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) IMPLEMENTATION OF THE PROVISIONS OF THE VOTING... information relating to the electoral process, including ballots, it shall provide them in the language of the...

Factors Associated With Adherence to Methylphenidate Treatment in Adult Patients With Attention-Deficit/Hyperactivity Disorder and Substance Use Disorders.

Science.gov (United States)

Skoglund, Charlotte; Brandt, Lena; Almqvist, Catarina; DʼOnofrio, Brian M; Konstenius, Maija; Franck, Johan; Larsson, Henrik

2016-06-01

Adherence to treatment is one of the most consistent factors associated with a favorable addiction treatment outcome. Little is known about factors associated with treatment adherence in individuals affected with comorbid attention-deficit/hyperactivity disorder and substance use disorders (SUD). This study aimed to explore whether treatment-associated factors, such as the prescribing physician's (sub)specialty and methylphenidate (MPH) dose, or patient-related factors, such as sex, age, SUD subtype, and psychiatric comorbidity, were associated with adherence to MPH treatment. Swedish national registers were used to identify adult individuals with prescriptions of MPH and medications specifically used in the treatment of SUD or a diagnosis of SUD and/or coexisting psychiatric diagnoses. Primary outcome measure was days in active MPH treatment in stratified dose groups (≤36 mg, ≥37 mg to ≤54 mg, ≥55 mg to ≤72 mg, ≥73 mg to ≤90 mg, ≥91 mg to ≤108 mg, and ≥109 mg). Lower MPH doses (ie, ≤36 mg day 100) were associated with treatment discontinuation between days 101 and 830 (HR≤36 mg, 1.67; HR37-54mg, 1.37; HR55-72mg, 1.36; HR73-90mg, 1.19; HR≥108mg, 1.09). The results showed a linear trend (P attention-deficit/hyperactivity disorder and SUD.

Worklife expectancy in a cohort of Danish employees aged 55-65 years - comparing a multi-state Cox proportional hazard approach with conventional multi-state life tables.

Science.gov (United States)

Pedersen, Jacob; Bjorner, Jakob Bue

2017-11-15

Work life expectancy (WLE) expresses the expected time a person will remain in the labor market until he or she retires. This paper compares a life table approach to estimating WLE to an approach based on multi-state proportional hazards models. The two methods are used to estimate WLE in Danish members and non-members of an early retirement pensioning (ERP) scheme according to levels of health. In 2008, data on self-rated health (SRH) was collected from 5212 employees 55-65 years of age. Data on previous and subsequent long-term sickness absence, unemployment, returning to work, and disability pension was collected from national registers. WLE was estimated from multi-state life tables and through multi-state models. Results from the multi-state model approach agreed with the life table approach but provided narrower confidence intervals for small groups. The shortest WLE was seen for employees with poor SRH and ERP membership while the longest WLE was seen for those with good SRH and no ERP membership. Employees aged 55-56 years with poor SRH but no ERP membership had shorter WLE than employees with good SRH and ERP membership. Relative WLE reversed for the two groups after age 57. At age 55, employees with poor SRH could be expected to spend approximately 12 months on long-term sick leave and 9-10 months unemployed before they retired - regardless of ERP membership. ERP members with poor SRH could be expected to spend 4.6 years working, while non-members could be expected to spend 7.1 years working. WLE estimated through multi-state models provided an effective way to summarize complex data on labor market affiliation. WLE differed noticeably between members and non-members of the ERP scheme. It has been hypothesized that while ERP membership would prompt some employees to retire earlier than they would have done otherwise, this effect would be partly offset by reduced time spent on long-term sick leave or unemployment. Our data showed no indication of

TA-55 change control manual

International Nuclear Information System (INIS)

Blum, T.W.; Selvage, R.D.; Courtney, K.H.

1997-11-01

This manual is the guide for initiating change at the Plutonium Facility, which handles the processing of plutonium as well as research on plutonium metallurgy. It describes the change and work control processes employed at TA-55 to ensure that all proposed changes are properly identified, reviewed, approved, implemented, tested, and documented so that operations are maintained within the approved safety envelope. All Laboratory groups, their contractors, and subcontractors doing work at TA-55 follow requirements set forth herein. This manual applies to all new and modified processes and experiments inside the TA-55 Plutonium Facility; general plant project (GPP) and line item funded construction projects at TA-55; temporary and permanent changes that directly or indirectly affect structures, systems, or components (SSCs) as described in the safety analysis, including Facility Control System (FCS) software; and major modifications to procedures. This manual does not apply to maintenance performed on process equipment or facility SSCs or the replacement of SSCs or equipment with documented approved equivalents

Magnetocaloric effects in Mn1.35Fe0.65P1−xSix compounds

International Nuclear Information System (INIS)

Geng Yao-Xiang; Tegus O; Bi Li-Ge

2012-01-01

The structural and magnetocaloric properties of Mn 1.35 Fe 0.65 P 1−x Si x compounds are investigated. The Si-substituted compounds, Mn 1.35 Fe 0.65 P 1−x Si x with x = 0.52, 0.54, 0.55, 0.56, and 0.57, are prepared by high-energy ball milling and the solid-state reaction. The X-ray diffraction shows that the compounds crystallize into the Fe 2 P-type hexagonal structure with space group P6-bar2m. The magnetic measurements show that the Curie temperature of the compound increases from 253 K for x = 0.52 to 296 K for x = 0.56. The isothermal magnetic-entropy change of the Mn 1.35 Fe 0.65 P 1−x Si x compound decreases with the Si content increasing. The maximal value of the magnetic-entropy change is about 7.0 J/kg·K in the Mn 1.35 Fe 0.65 P 0.48 Si 0.52 compound with a field change of 1.5 T. The compound quenched in water possesses a larger magnetic entropy change and a smaller thermal hysteresis than the non-quenched samples. The thermal hysteresis of the compound is less than 3.5 K. The maximum adiabatic temperature change is about 1.4 K in the Mn 1.35 Fe 0.65 P 0.45 Si 0.55 compound with a field change of 1.48 T. (condensed matter: electronic structure, electrical, magnetic, and optical properties)

10 CFR 55.4 - Definitions.

Science.gov (United States)

2010-01-01

... part-task and limited scope simulation devices, approved under § 55.46(b). Systems approach to training means a training program that includes the following five elements: (1) Systematic analysis of the jobs... means the Atomic Energy Act of 1954, including any amendments to the Act. Actively performing the...

Efectos de la respiración controlada sobre los síntomas de estrés y ansiedad en una población de 55 a 65 años: estudio piloto

Directory of Open Access Journals (Sweden)

José Ignacio Cea Ugarte

2015-03-01

Full Text Available Este estudio evaluó una terapia, la respiración manejada a voluntad, sobre la ansiedad y el estrés en una población con edades comprendidas entre 55 y 65 años. Un total de 54 sujetos fueron asignados a un grupo de tratamiento, de información sobre estrés, y a un grupo sin intervención. Un diseño experimental con medidas repetidas para la evaluación pretratamiento y postratamiento mostró, después de 3 semanas, un descenso significativo en síntomas de estrés en el grupo experimental. La variabilidad en los grupos y el pequeño número de sesiones podría explicar que no se encontraran diferencias intergrupales significativas.

High prevalence of frequent attendance in the over 65s.

Science.gov (United States)

McMahon, C Geraldine; Power Foley, Megan; Robinson, David; O'Donnell, Kate; Poulton, Miriam; Kenny, Rose A; Bennett, Kathleen

2018-02-01

Characteristics of older frequent users of Emergency Departments (EDs) are poorly understood. Our aim was to examine the characteristics of the ED frequent attenders (FAs) by age (under 65 and over 65 years). We examined the prevalence of FA attending the ED of an Urban Teaching Hospital in a cross-sectional study between 2009 and 2011. FA was defined as an individual who presented to the ED four or more times over a 12-month period. Randomly selected groups of FA and non-FA from two age groups (under 65 and over 65 years) were then examined to compare the characteristics between older FAs and non-FAs and older FAs and younger FAs. Logistic regression was used to calculate the odds ratio and 95% confidence intervals for 12-month mortality in FA compared with non-FA aged at least 65 years. Overall, 137 150 ED attendances were recorded between 2009 and 2011. A total of 21.6% were aged at least 65 years, 4.4% of whom were FAs, accounting for 18.4% of attendances by patients older than 65 years. There was a bimodal age distribution of FA (mean±SD; under 65 years 40±12.7; and over 65 years 76.9±7.4). Older FAs were five times more likely to present outside normal working hours and 5.5 times more likely to require admission. Cardiovascular emergencies were the most common complaint, in contrast with the younger FA group, where injury and psychosocial conditions dominated. The odds ratio for death at 12 months was 2.07 (95% confidence interval 0.93-4.63; P=0.07), adjusting for age and sex. One-in-five ED patients older than 65 years of age are FAs. Older FAs largely present with complex medical conditions. Enhanced access to expert gerontology assessment should be considered as part of effective intervention strategies for older ED users.

Heteroduplex DNA position defines the roles of the Sgs1, Srs2, and Mph1 helicases in promoting distinct recombination outcomes.

Directory of Open Access Journals (Sweden)

Katrina Mitchel

Full Text Available The contributions of the Sgs1, Mph1, and Srs2 DNA helicases during mitotic double-strand break (DSB repair in yeast were investigated using a gap-repair assay. A diverged chromosomal substrate was used as a repair template for the gapped plasmid, allowing mismatch-containing heteroduplex DNA (hDNA formed during recombination to be monitored. Overall DSB repair efficiencies and the proportions of crossovers (COs versus noncrossovers (NCOs were determined in wild-type and helicase-defective strains, allowing the efficiency of CO and NCO production in each background to be calculated. In addition, the products of individual NCO events were sequenced to determine the location of hDNA. Because hDNA position is expected to differ depending on whether a NCO is produced by synthesis-dependent-strand-annealing (SDSA or through a Holliday junction (HJ-containing intermediate, its position allows the underlying molecular mechanism to be inferred. Results demonstrate that each helicase reduces the proportion of CO recombinants, but that each does so in a fundamentally different way. Mph1 does not affect the overall efficiency of gap repair, and its loss alters the CO-NCO by promoting SDSA at the expense of HJ-containing intermediates. By contrast, Sgs1 and Srs2 are each required for efficient gap repair, strongly promoting NCO formation and having little effect on CO efficiency. hDNA analyses suggest that all three helicases promote SDSA, and that Sgs1 and Srs2 additionally dismantle HJ-containing intermediates. The hDNA data are consistent with the proposed role of Sgs1 in the dissolution of double HJs, and we propose that Srs2 dismantles nicked HJs.

Worklife expectancy in a cohort of Danish employees aged 55–65 years - comparing a multi-state Cox proportional hazard approach with conventional multi-state life tables

Directory of Open Access Journals (Sweden)

Jacob Pedersen

2017-11-01

Full Text Available Abstract Background Work life expectancy (WLE expresses the expected time a person will remain in the labor market until he or she retires. This paper compares a life table approach to estimating WLE to an approach based on multi-state proportional hazards models. The two methods are used to estimate WLE in Danish members and non-members of an early retirement pensioning (ERP scheme according to levels of health. Methods In 2008, data on self-rated health (SRH was collected from 5212 employees 55–65 years of age. Data on previous and subsequent long-term sickness absence, unemployment, returning to work, and disability pension was collected from national registers. WLE was estimated from multi-state life tables and through multi-state models. Results Results from the multi-state model approach agreed with the life table approach but provided narrower confidence intervals for small groups. The shortest WLE was seen for employees with poor SRH and ERP membership while the longest WLE was seen for those with good SRH and no ERP membership. Employees aged 55–56 years with poor SRH but no ERP membership had shorter WLE than employees with good SRH and ERP membership. Relative WLE reversed for the two groups after age 57. At age 55, employees with poor SRH could be expected to spend approximately 12 months on long-term sick leave and 9–10 months unemployed before they retired – regardless of ERP membership. ERP members with poor SRH could be expected to spend 4.6 years working, while non-members could be expected to spend 7.1 years working. Conclusion WLE estimated through multi-state models provided an effective way to summarize complex data on labor market affiliation. WLE differed noticeably between members and non-members of the ERP scheme. It has been hypothesized that while ERP membership would prompt some employees to retire earlier than they would have done otherwise, this effect would be partly offset by reduced time spent on

Effects of Organized Physical Activity on Selected Health Indices among Women Older than 55 Years

Directory of Open Access Journals (Sweden)

Piotr Zmijewski

2015-01-01

Full Text Available The main aim of this study was to determine health benefits among women older than 55 years who participated in organized, group-based physical activity (OPA. Thirty-five women aged 65.0 ± 7.3 years volunteered for this study. The classical and nonclassical cardiovascular (CVD risk factors were measured before and after a 2-week OPA camp in a remote location and 3 months of OPA. Self-guided physical activity was analyzed 18 months after OPA. Two-week effects included significant decreases in body mass index, waist and hip circumferences, resting systolic and diastolic blood pressure (BP and resting heart rate, improved exercise capacity (EC, improved low-density lipoprotein and high-density lipoprotein (HDL-C, cholesterol, and other atherogenic lipid indices (ALI, and a reduction in 10-year estimated risk of death from CVD. Three-month effects included a further decrease in systolic BP, improvements in EC and HDL-C, and maintenance of lower levels of ALI, as well as lower CVD risk. The implementation of the OPA programme had a positive impact on somatic features, exercise capacity, biochemical indices, and risk for death from CVD. The presented programme can be regarded as an effective element of primary prevention of cardiovascular diseases among women older than 55 years.

Subjective effects, misuse, and adverse effects of osmotic-release methylphenidate treatment in adolescent substance abusers with attention-deficit/hyperactivity disorder.

Science.gov (United States)

Winhusen, Theresa M; Lewis, Daniel F; Riggs, Paula D; Davies, Robert D; Adler, Lenard A; Sonne, Susan; Somoza, Eugene C

2011-10-01

Psychostimulants are effective treatments for attention-deficit/hyperactivity disorder (ADHD) but may be associated with euphoric effects, misuse/diversion, and adverse effects. These risks are perceived by some clinicians to be greater in substance-abusing adolescents relative to non-substance-abusing adults. The present study evaluates the subjective effects, misuse/diversion, and adverse effects associated with the use of osmotic-release oral system methylphenidate (OROS-MPH), relative to placebo, for treating ADHD in adolescents with a substance use disorder (SUD) as a function of substance use severity and compared these risks with those associated with the treatment of ADHD in adults without a non-nicotine SUD. Datasets from two randomized placebo-controlled trials of OROS-MPH for treating ADHD, one conducted with 303 adolescents (13-18) with at least one non-nicotine SUD and one with 255 adult smokers (18-55), were analyzed. Outcome measures included the Massachusetts General Hospital Liking Scale, self-reported medication compliance, pill counts, and adverse events (AEs). Euphoric effects and misuse/diversion of OROS-MPH were not significantly affected by substance use severity. The euphoric effects of OROS-MPH did not significantly differ between the adolescent and adult samples. Adults rated OROS-MPH as more effective in treating ADHD, whereas adolescents reported feeling more depressed when taking OROS-MPH. The adolescents lost more pills relative to the adults regardless of treatment condition, which suggests the importance of careful medication monitoring. Higher baseline use of alcohol and cannabis was associated with an increased risk of experiencing a treatment-related AE in OROS-MPH, but baseline use did not increase the risk of serious AEs or of any particular category of AE and the adolescents did not experience more treatment-related AEs relative to the adults. With good monitoring, and in the context of substance abuse treatment, OROS-MPH can

A Wideband Balun LNA I/Q-Mixer combination in 65nm CMOS

NARCIS (Netherlands)

Blaakmeer, S.C.; Klumperink, Eric A.M.; Leenaerts, D.M.W.; Nauta, Bram

2008-01-01

An inductor-less LNA-mixer topology merges an I/Q current-commutating mixer with a noise-canceling balun/LNA. The topology achieves >18dB conversion gain, a flat NF<5.5dB, IIP2=+20dBm and IIP3=-3dBm from 500MHz to 7GHz. The core circuit consumes 16mW and occupies less than 0.01mm2 in 65nm CMOS.

The validation of a French-language version of the Aging Perceptions Questionnaire (APQ) and its extension to a population aged 55 and over

LENUS (Irish Health Repository)

Ingrand, Isabelle

2012-04-30

AbstractBackgroundSeveral studies have shown the influence of the perceptions of aging on the cognitive functioning and the mental and physical health of older people. These relationships have not to date been studied in France where validated instruments are lacking. The primary objective of this study was to validate a French-language version of the Aging Perceptions Questionnaire (APQ) in the French general population aged 65 and over. The secondary objective was to study the stability of the dimensions of this instrument among participants aged 55 to 64.MethodsThe study was proposed to the cohort of the Observatoire Régional du Vieillissement (OPREVI) (observatory of aging), located in a small town in Poitou-Charentes (western France). An anonymous questionnaire including the APQ was sent by mail to inhabitants aged 55 and over. The original English language APQ was described with adults aged 65 and older. It has 32 items distributed on 7 dimensions: timeline chronic and cyclical, positive and negative consequences, positive and negative control and emotional representations.Results656 adults participated in this survey (286 men, 370 women). Among those aged 65 and over (n = 394), the seven-factor structure estimated by confirmatory factor analysis was coherent with original findings. Internal consistency as evaluated by Cronbach alpha, was between 0.83 for consequences negative and 0.52 for control negative. Several dimensions were strongly correlated. Among participants aged 55 to 64 (n = 262), the same factorial model yielded an acceptable fit. Multi-group confirmatory factor analysis concluded to approximate factorial invariance between the two age groups with a null delta in comparative fit index.ConclusionThis study among French people aged 65 and over, added further evidence of the multidimensional structure of the French version of the APQ which is superimposed to the dimensions of the original Irish version. The same factorial structure

Zinc-65 metabolism in two newt species (Taricha granulosa and Notophthalmus viridescens)

International Nuclear Information System (INIS)

Willis, David L.; Valett, Bryan B.

1978-01-01

Uptake of 65 Zn from water by the rough-skinned newt (Taricha granulosa) at 10 deg C was followed for 55 days. An equilibrium body burden was attained by 30 days. These animals were then transferred to clean water and their declining body burdens traced for 144 days. Two distinct loss components were evident. The slower component exhibited a biological half-life (T b ) of 3-1/3 years and accounted for over 90% of the initial body burden. Nearly identical results were obtained when the 65 Zn was administered by injection. Whole-body retention studies conducted at room temperature with Taricha g. and the red-spotted newt (Notophthalmus viridescens) where the 65 Zn was initially injected yielded T b values of 1-1/2 years. Comparison with the results obtained at 10 deg C strongly suggests that zinc excretion is directly related to ambient temperature. The pattern of 65 Zn distribution in 13 tissues and organs of Taricha g. was investigated following injection at 10 deg C. Highest concentrations were consistently found in skin, muscle, blood and liver. At 3 months these accounted for 70% of the body burden. These results suggest that newts, with their rapid intake of 65 Zn, long T b and predominant body burden in edible tissues, may be important species in the transfer of radiozinc in fresh-water and terrestrial food webs. (author)

Impact of attention-deficit/hyperactivity disorder (ADHD) treatment on smoking cessation intervention in ADHD smokers: a randomized, double-blind, placebo-controlled trial.

Science.gov (United States)

Winhusen, Theresa M; Somoza, Eugene C; Brigham, Gregory S; Liu, David S; Green, Carla A; Covey, Lirio S; Croghan, Ivana T; Adler, Lenard A; Weiss, Roger D; Leimberger, Jeffrey D; Lewis, Daniel F; Dorer, Emily M

2010-12-01

High smoking rates in adults with attention-deficit/hyperactivity disorder (ADHD) and nicotine's amelioration of ADHD suggest that effective ADHD treatment might facilitate abstinence in smokers with ADHD. The present study evaluated if using osmotic-release oral system methylphenidate (OROS-MPH) to treat ADHD enhances response to smoking cessation treatment in smokers with ADHD. A randomized, double-blind, placebo-controlled, 11-week trial with a 1-month follow-up was conducted at 6 clinical sites between December 2005 and January 2008. Adults (aged 18-55 years) meeting DSM-IV criteria for ADHD and interested in quitting smoking were randomly assigned to OROS-MPH titrated to 72 mg/d (n = 127) or placebo (n = 128). All participants received brief weekly individual smoking cessation counseling for 11 weeks and 21 mg/d nicotine patches starting on the smoking quit day (day 27) through study week 11. Outcome measures included prolonged smoking abstinence and DSM-IV ADHD Rating Scale (ADHD-RS) score. Of 255 randomly assigned participants, 204 (80%) completed the trial. Prolonged abstinence rates, 43.3% and 42.2%, for the OROS-MPH and placebo groups, respectively, did not differ significantly (OR = 1.1; 95% CI, 0.63-1.79; P = .81). Relative to placebo, OROS-MPH evidenced a greater reduction in DSM-IV ADHD-RS score (P ADHD did not improve smoking cessation success; OROS-MPH, relative to placebo, effectively treated ADHD and was safe and generally well tolerated in this healthy sample of adult ADHD smokers. clinical trials.gov Identifier: NCT00253747. © Copyright 2010 Physicians Postgraduate Press, Inc.

Bacterial spore inactivation at 45-65 °C using high pressure processing: study of Alicyclobacillus acidoterrestris in orange juice.

Science.gov (United States)

Silva, Filipa V M; Tan, Eng Keat; Farid, Mohammed

2012-10-01

High pressure processing (HPP) is a new non-thermal technology commercially used to pasteurize fruit juices and extend shelf-life, while preserving delicate aromas/flavours and bioactive constituents. Given the spoilage incidents and economic losses due to Alicyclobacillus acidoterrestris in the fruit juice industry, the use of high pressure (200 MPa - 600 MPa) in combination with mild temperature (45 °C-65 °C) for 1-15 min, to inactivate these spores in orange juice were investigated. As expected, the higher the temperature, pressure and time, the larger was the A. acidoterrestris inactivation. The survival curves were described by the first order Bigelow model. For 200 MPa, D(45 °C) = 43.9 min, D(55 °C) = 28.8 min, D(65 °C) = 5.0 min and z-value = 21.3 °C. At 600 MPa, D(45 °C) = 12.9 min, D(55 °C) = 7.0 min, D(65 °C) = 3.4 min and z-value = 34.4 °C. Spores were inactivated at 45 °C and 600 MPa, and at 65 °C only 200 MPa was needed to achieve reduction in spore numbers. Results demonstrated that HPP allowed A. acidoterrestris spore inactivation at lower temperatures (45-65 °C) than conventional thermal processing (85-95 °C) without pressure, yielding a fresher and higher quality preserved food. Copyright © 2012 Elsevier Ltd. All rights reserved.

Water Solubility of Plutonium and Uranium Compounds and Residues at TA-55

International Nuclear Information System (INIS)

Reilly, Sean Douglas; Smith, Paul Herrick; Jarvinen, Gordon D.; Prochnow, David Adrian; Schulte, Louis D.; DeBurgomaster, Paul Christopher; Fife, Keith William; Rubin, Jim; Worl, Laura Ann

2016-01-01

Understanding the water solubility of plutonium and uranium compounds and residues at TA-55 is necessary to provide a technical basis for appropriate criticality safety, safety basis and accountability controls. Individual compound solubility was determined using published solubility data and solution thermodynamic modeling. Residue solubility was estimated using a combination of published technical reports and process knowledge of constituent compounds. The scope of materials considered includes all compounds and residues at TA-55 as of March 2016 that contain Pu-239 or U-235 where any single item in the facility has more than 500 g of nuclear material. This analysis indicates that the following materials are not appreciably soluble in water: plutonium dioxide (IDC=C21), plutonium phosphate (IDC=C66), plutonium tetrafluoride (IDC=C80), plutonium filter residue (IDC=R26), plutonium hydroxide precipitate (IDC=R41), plutonium DOR salt (IDC=R42), plutonium incinerator ash (IDC=R47), uranium carbide (IDC=C13), uranium dioxide (IDC=C21), U 3 O 8 (IDC=C88), and uranium filter residue (IDC=R26). This analysis also indicates that the following materials are soluble in water: plutonium chloride (IDC=C19) and uranium nitrate (IDC=C52). Equilibrium calculations suggest that PuOCl is water soluble under certain conditions, but some plutonium processing reports indicate that it is insoluble when present in electrorefining residues (R65). Plutonium molten salt extraction residues (IDC=R83) contain significant quantities of PuCl 3 , and are expected to be soluble in water. The solubility of the following plutonium residues is indeterminate due to conflicting reports, insufficient process knowledge or process-dependent composition: calcium salt (IDC=R09), electrorefining salt (IDC=R65), salt (IDC=R71), silica (IDC=R73) and sweepings/screenings (IDC=R78). Solution thermodynamic modeling also indicates that fire suppression water buffered with a commercially-available phosphate

Water Solubility of Plutonium and Uranium Compounds and Residues at TA-55

Energy Technology Data Exchange (ETDEWEB)

Reilly, Sean Douglas [Los Alamos National Lab. (LANL), Los Alamos, NM (United States; Smith, Paul Herrick [Los Alamos National Lab. (LANL), Los Alamos, NM (United States; Jarvinen, Gordon D. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States; Prochnow, David Adrian [Los Alamos National Lab. (LANL), Los Alamos, NM (United States; Schulte, Louis D. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States; DeBurgomaster, Paul Christopher [Los Alamos National Lab. (LANL), Los Alamos, NM (United States; Fife, Keith William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States; Rubin, Jim [Los Alamos National Lab. (LANL), Los Alamos, NM (United States; Worl, Laura Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States

2016-06-13

Understanding the water solubility of plutonium and uranium compounds and residues at TA-55 is necessary to provide a technical basis for appropriate criticality safety, safety basis and accountability controls. Individual compound solubility was determined using published solubility data and solution thermodynamic modeling. Residue solubility was estimated using a combination of published technical reports and process knowledge of constituent compounds. The scope of materials considered includes all compounds and residues at TA-55 as of March 2016 that contain Pu-239 or U-235 where any single item in the facility has more than 500 g of nuclear material. This analysis indicates that the following materials are not appreciably soluble in water: plutonium dioxide (IDC=C21), plutonium phosphate (IDC=C66), plutonium tetrafluoride (IDC=C80), plutonium filter residue (IDC=R26), plutonium hydroxide precipitate (IDC=R41), plutonium DOR salt (IDC=R42), plutonium incinerator ash (IDC=R47), uranium carbide (IDC=C13), uranium dioxide (IDC=C21), U₃O₈ (IDC=C88), and uranium filter residue (IDC=R26). This analysis also indicates that the following materials are soluble in water: plutonium chloride (IDC=C19) and uranium nitrate (IDC=C52). Equilibrium calculations suggest that PuOCl is water soluble under certain conditions, but some plutonium processing reports indicate that it is insoluble when present in electrorefining residues (R65). Plutonium molten salt extraction residues (IDC=R83) contain significant quantities of PuCl₃, and are expected to be soluble in water. The solubility of the following plutonium residues is indeterminate due to conflicting reports, insufficient process knowledge or process-dependent composition: calcium salt (IDC=R09), electrorefining salt (IDC=R65), salt (IDC=R71), silica (IDC=R73) and sweepings/screenings (IDC=R78). Solution thermodynamic modeling also indicates that fire suppression water buffered with a

Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome.

Directory of Open Access Journals (Sweden)

Md Mahiuddin Ahmed

Full Text Available Down syndrome (DS is caused by an extra copy of human chromosome 21 (Hsa21. Although it is the most common genetic cause of intellectual disability (ID, there are, as yet, no effective pharmacotherapies. The Ts65Dn mouse model of DS is trisomic for orthologs of ∼55% of Hsa21 classical protein coding genes. These mice display many features relevant to those seen in DS, including deficits in learning and memory (L/M tasks requiring a functional hippocampus. Recently, the N-methyl-D-aspartate (NMDA receptor antagonist, memantine, was shown to rescue performance of the Ts65Dn in several L/M tasks. These studies, however, have not been accompanied by molecular analyses. In previous work, we described changes in protein expression induced in hippocampus and cortex in control mice after exposure to context fear conditioning (CFC, with and without memantine treatment. Here, we extend this analysis to Ts65Dn mice, measuring levels of 85 proteins/protein modifications, including components of MAP kinase and MTOR pathways, and subunits of NMDA receptors, in cortex and hippocampus of Ts65Dn mice after failed learning in CFC and after learning was rescued by memantine. We show that, compared with wild type littermate controls, (i of the dynamic responses seen in control mice in normal learning, >40% also occur in Ts65Dn in failed learning or are compensated by baseline abnormalities, and thus are considered necessary but not sufficient for successful learning, and (ii treatment with memantine does not in general normalize the initial protein levels but instead induces direct and indirect responses in approximately half the proteins measured and results in normalization of the endpoint protein levels. Together, these datasets provide a first view of the complexities associated with pharmacological rescue of learning in the Ts65Dn. Extending such studies to additional drugs and mouse models of DS will aid in identifying pharmacotherapies for effective

The role of oral physiciand inpredicting the risk of obstructive sleep apnea: A case-control study

International Nuclear Information System (INIS)

Lavanya, Reddy; Babu, Dara Balaji Gandhi; Chavva, Sunandha; Boringi, Mamatha; Waghray, Shefali; Yeladandi, Mounica

2016-01-01

Obstructive sleep apnea (OSA) is a common medical disorder with serious complications if untreated. Dentists play a vital role in the early diagnosis of this condition, thereby improving patients' prognoses. The purpose of this study was to identify patients with a high risk of OSA using simple cephalometric measurements in patients receiving routine dental care. The present study was conducted on 206 patients divided into a high-risk group and a control group after answering the Berlin questionnaire. Cephalometric analysis of a digital cephalogram was performed to measure the upper airway diameter (UAD) and mandibular-to-hyoid bone distance (MP-H) by 2 observers at 2 different times. Among 206 patients, 93 (45%) were included in the high-risk group and 113 (55%) were in the control group. No significant difference was present between the groups with regard to gender, and the patients ranged in age from 18 to 65 years. The UAD measurements in the high-risk group were significantly lower than in the control group, and the MP-H measurements were significantly higher in the high-risk group than in the control group. The UAD was lower in middle-aged patients in both groups. Our study found that the UAD was lower in individuals with a high risk of OSA. Also, we found that middle-aged individuals of both genders were more likely to develop OSA. Dentists play a vital role in diagnosing patients at a high risk for OSA via thorough clinical examinations, risk factor analyses, and simple cephalometric analyses

The role of oral physiciand inpredicting the risk of obstructive sleep apnea: A case-control study

Energy Technology Data Exchange (ETDEWEB)

Lavanya, Reddy; Babu, Dara Balaji Gandhi; Chavva, Sunandha; Boringi, Mamatha; Waghray, Shefali; Yeladandi, Mounica [Dept. of Oral Medicine and Radiology, Panineeya Institute of Dental Sciences and Research Centre, Hyderabad (India)

2016-09-15

Obstructive sleep apnea (OSA) is a common medical disorder with serious complications if untreated. Dentists play a vital role in the early diagnosis of this condition, thereby improving patients' prognoses. The purpose of this study was to identify patients with a high risk of OSA using simple cephalometric measurements in patients receiving routine dental care. The present study was conducted on 206 patients divided into a high-risk group and a control group after answering the Berlin questionnaire. Cephalometric analysis of a digital cephalogram was performed to measure the upper airway diameter (UAD) and mandibular-to-hyoid bone distance (MP-H) by 2 observers at 2 different times. Among 206 patients, 93 (45%) were included in the high-risk group and 113 (55%) were in the control group. No significant difference was present between the groups with regard to gender, and the patients ranged in age from 18 to 65 years. The UAD measurements in the high-risk group were significantly lower than in the control group, and the MP-H measurements were significantly higher in the high-risk group than in the control group. The UAD was lower in middle-aged patients in both groups. Our study found that the UAD was lower in individuals with a high risk of OSA. Also, we found that middle-aged individuals of both genders were more likely to develop OSA. Dentists play a vital role in diagnosing patients at a high risk for OSA via thorough clinical examinations, risk factor analyses, and simple cephalometric analyses.

WIN 55,212-2, agonist of cannabinoid receptors, prevents amyloid β1-42 effects on astrocytes in primary culture.

Directory of Open Access Journals (Sweden)

Diana Aguirre-Rueda

Full Text Available Alzheimer's disease (AD, a neurodegenerative illness involving synaptic dysfunction with extracellular accumulation of Aβ1-42 toxic peptide, glial activation, inflammatory response and oxidative stress, can lead to neuronal death. Endogenous cannabinoid system is implicated in physiological and physiopathological events in central nervous system (CNS, and changes in this system are related to many human diseases, including AD. However, studies on the effects of cannabinoids on astrocytes functions are scarce. In primary cultured astrocytes we studied cellular viability using MTT assay. Inflammatory and oxidative stress mediators were determined by ELISA and Western-blot techniques both in the presence and absence of Aβ1-42 peptide. Effects of WIN 55,212-2 (a synthetic cannabinoid on cell viability, inflammatory mediators and oxidative stress were also determined. Aβ1-42 diminished astrocytes viability, increased TNF-α and IL-1β levels and p-65, COX-2 and iNOS protein expression while decreased PPAR-γ and antioxidant enzyme Cu/Zn SOD. WIN 55,212-2 pretreatment prevents all effects elicited by Aβ1-42. Furthermore, cannabinoid WIN 55,212-2 also increased cell viability and PPAR-γ expression in control astrocytes. In conclusion cannabinoid WIN 55,212-2 increases cell viability and anti-inflammatory response in cultured astrocytes. Moreover, WIN 55,212-2 increases expression of anti-oxidant Cu/Zn SOD and is able to prevent inflammation induced by Aβ1-42 in cultured astrocytes. Further studies would be needed to assess the possible beneficial effects of cannabinoids in Alzheimer's disease patients.

Temperature increases from 55 to 75 C in a two-phase biogas reactor result in fundamental alterations within the bacterial and archaeal community structure

Energy Technology Data Exchange (ETDEWEB)

Rademacher, Antje [Leibniz-Institut fuer Agrartechnik Potsdam-Bornim e.V. (ATB), Potsdam (Germany). Abt. Bioverfahrenstechnik; Technische Univ. Berlin (Germany). Inst. fuer Technischen Umweltschutz; Nolte, Christine; Schoenberg, Mandy; Klocke, Michael [Leibniz-Institut fuer Agrartechnik Potsdam-Bornim e.V. (ATB), Potsdam (Germany). Abt. Bioverfahrenstechnik

2012-10-15

Agricultural biogas plants were operated in most cases below their optimal performance. An increase in the fermentation temperature and a spatial separation of hydrolysis/acetogenesis and methanogenesis are known strategies in improving and stabilizing biogas production. In this study, the dynamic variability of the bacterial and archaeal community was monitored within a two-phase leach bed biogas reactor supplied with rye silage and straw during a stepwise temperature increase from 55 to 75 C within the leach bed reactor (LBR), using TRFLP analyses. To identify the terminal restriction fragments that were obtained, bacterial and archaeal 16S rRNA gene libraries were constructed. Above 65 C, the bacterial community structure changed from being Clostridiales-dominated toward being dominated by members of the Bacteroidales, Clostridiales, and Thermotogales orders. Simultaneously, several changes occurred, including a decrease in the total cell count, degradation rate, and biogas yield along with alterations in the intermediate production. A bioaugmentation with compost at 70 C led to slight improvements in the reactor performance; these did not persist at 75 C. However, the archaeal community within the downstream anaerobic filter reactor (AF), operated constantly at 55 C, altered by the temperature increase in the LBR. At an LBR temperature of 55 C, members of the Methanobacteriales order were prevalent in the AF, whereas at higher LBR temperatures Methanosarcinales prevailed. Altogether, the best performance of this two-phase reactor was achieved at an LBR temperature of below 65 C, which indicates that this temperature range has a favorable effect on the microbial community responsible for the production of biogas. (orig.)

Effect of NaCl on thermophilic (55°C) methanol degradation in sulfate reducing granular sludge reactors

NARCIS (Netherlands)

Vallero, M.V.G.; Hulshoff Pol, L.W.; Lettinga, G.; Lens, P.N.L.

2003-01-01

The effect of NaCl on thermophilic (55degreesC) methanol conversion in the presence of excess of sulfate (COD/SO42-=0.5) was investigated in two 6.5L lab-scale upflow anaerobic sludge bed reactors inoculated with granular sludge previously not adapted to NaCl
The effect of NaCl on thermophilic

Hidroroute 55

Science.gov (United States)

Mas, M.; Eixarch, E.; Ortonobes, C.

2012-04-01

"HIDROROUTE 55" Saving water is a recurrent topic for students in Spain because the Mediterranean zone suffers periodically severe droughts. Any student knows it and is able to repeat some basic advices like "take showers instead of baths, or "close the tap when brushing your teeth..." But maybe this is a quite superficial awareness about shortage and saving water. Where does the home flowing water come from? How can we be sure that this water is clean and safe to drink? And, tomorrow or next week, will be there water in our tap? Perhaps working in these questions is a good way to understand how difficult is to get water to our homes. In order to deepen in the question we are preparing a teaching unit titled "Hydro route 55: from the Earth to la Maurina trough the water" on 1rst ESO level students (12 years old) of the secondary public school "Institut les Aymerigues" in Terrassa (Barcelona). Students' tasks will be to search information about the way water gets to their homes, including water cycle, treatment and saving water... This unit belongs to an integrated project with all areas involved (history, mathematics, technology, languages and music) that aims to approach students to different aspects of their zone in Terrassa (La Maurina) and it will be implemented at the end of the second term, just some weeks before the Vienna's meeting. School and teaching team: Institut les Aymerigues is a new school that this year has only 1rst ESO students (12 years old). Teaching staff is engaged in developing an integrated and based on competences curriculum. In this context we integrate English and Science content in a unified teaching schedule of six hours per week for the students. One English teacher and two Science teachers are involved in it. In addition we have three student teachers from "Master of Secondary Teachers Training" that are in charge of preparing the Hydroroute 55 activities with the titular teachers. We illustrate students' tasks such as the

Switch in Therapy from Methylphenidate to Atomoxetine in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder

DEFF Research Database (Denmark)

Warrer, Pernille; Thomsen, Per Hove; Dalsgaard, Søren

2016-01-01

to 2.5 years prior to switching. Most common reasons for switching were "adverse events" (AEs) (78%), "wish for more optimal day coverage" (24%), and "lack of efficacy" (16%). Other reasons for switching included "patient/parental request" (13%) and "noncompliance" (2%). Most common AEs leading...... switching to ATX, and the reasons leading to a switch in therapy. METHODS: We included 55 patients with ADHD who switched from first-line MPH to second-line ATX during January 01, 2012 and May 15, 2014. Patient and treatment characteristics along with clinical reasons for switching therapy were extracted...

Cost-effectiveness of extended-release methylphenidate in children and adolescents with attention-deficit/hyperactivity disorder sub-optimally treated with immediate release methylphenidate.

Directory of Open Access Journals (Sweden)

Jurjen van der Schans

Full Text Available Attention-Deficit/Hyperactivity Disorder (ADHD is a common psychiatric disorder in children and adolescents. Immediate-release methylphenidate (IR-MPH is the medical treatment of first choice. The necessity to use several IR-MPH tablets per day and associated potential social stigma at school often leads to reduced compliance, sub-optimal treatment, and therefore economic loss. Replacement of IR-MPH with a single-dose extended release (ER-MPH formulation may improve drug response and economic efficiency.To evaluate the cost-effectiveness from a societal perspective of a switch from IR-MPH to ER-MPH in patients who are sub-optimally treated.A daily Markov-cycle model covering a time-span of 10 years was developed including four different health states: (1 optimal response, (2 sub-optimal response, (3 discontinued treatment, and (4 natural remission. ER-MPH options included methylphenidate osmotic release oral system (MPH-OROS and Equasym XL/Medikinet CR. Both direct costs and indirect costs were included in the analysis, and effects were expressed as quality-adjusted life years (QALYs. Univariate, multivariate as well as probabilistic sensitivity analysis were conducted and the main outcomes were incremental cost-effectiveness ratios.Switching sub-optimally treated patients from IR-MPH to MPH-OROS or Equasym XL/Medikinet CR led to per-patient cost-savings of €4200 and €5400, respectively, over a 10-year treatment span. Sensitivity analysis with plausible variations of input parameters resulted in cost-savings in the vast majority of estimations.This study lends economic support to switching patients with ADHD with suboptimal response to short-acting IR-MPH to long-acting ER-MPH regimens.

47 CFR 65.820 - Included items.

Science.gov (United States)

2010-10-01

...) Cash working capital. The average amount of investor-supplied capital needed to provide funds for a carrier's day-to-day interstate operations. Class A carriers may calculate a cash working capital... study or using the formula in paragraph (e) of this section, may calculate the cash working capital...

Six months methylphenidate treatment improves emotion dysregulation in adolescents with attention deficit/hyperactivity disorder: a prospective study

Directory of Open Access Journals (Sweden)

Suzer Gamli I

2018-05-01

Full Text Available Ipek Suzer Gamli,1 Aysegul Yolga Tahiroglu2 1Sanliurfa Education and Research Hospital, Eyyubiye, Sanliurfa, Turkey; 2Child and Adolescent Psychiatry Department, Cukurova University School of Medicine, Saricam, Adana, Turkey Purpose: Individuals with attention deficit/hyperactivity disorder (ADHD may suffer from emotional dysregulation (ED, although this symptom is not listed among the diagnostic criteria. Methylphenidate (MPH is useful in reducing emotional symptoms in ADHD. The aim of the present study was to determine both psychosocial risk factors and presence of ED in adolescents with ADHD before and after MPH treatment. Participants and methods: Eighty-two patients aged 12–18 years with ADHD were included as participants. The Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children – Present and Lifetime, the Difficulties in Emotion Regulation Scale (DERS, sociodemographic form, and the Inventory of Statements About Self-Injury were administered. Results were compared before and after 6 months MPH treatment. Results: A significant improvement was detected on DERS for impulsivity (15.9±6.8 initial vs 14.2±6.5 final test, p<0.01 and total score (88.4±23.3 initial vs 82.4±2.7 final test, p<0.05 across all patients taking MPH regardless of subtype and sex. Despite treatment, a significant difference remained for impulsivity, strategies, and total score in patients with comorbid oppositional defiant disorder (ODD compared with those without ODD, but no difference was detected for conduct disorder comorbidity. In patients who self-harm, scores for goals, impulsivity, strategies, clarity, and total score were higher before treatment: furthermore, impulsivity and total score remained high after treatment. In maltreated patients, goals, impulsivity, strategies, and total scores were significantly higher before treatment; however, their symptoms were ameliorated after treatment with MPH. Conclusion: Individuals with

Catalog of 3 < z < 5.5 Quasar Candidates Selected among XMM-Newton Sources and Its Spectroscopic Verification

Energy Technology Data Exchange (ETDEWEB)

Khorunzhev, Georgii; Sazonov, Sergey; Burenin, Rodion [High Energy Astrophysics, Space Research Institute, Russian Academy of Sciences, Moscow (Russian Federation); Eselevich, Maxim, E-mail: horge@iki.rssi.ru [Laboratory of Infrared Methods in Astrophysics, Institute of Solar-Terrestrial Physics, Russian Academy of Sciences, Irkutsk (Russian Federation)

2017-11-13

We have compiled a catalog of 903 quasar candidates (including known quasars) at 3 < z < 5.5 selected among X-ray sources from the XMM-Newton serendipitous survey (3XMM-DR4 catalog). We used photometric SDSS, 2MASS, and WISE data to select the objects. The surface number density of objects in our sample exceeds that in the SDSS spectroscopic quasar sample at the same redshifts by a factor of 1.5. We have performed spectroscopic observations of a subsample of new quasar candidates using a new low- and medium-resolution spectrograph at the 1.6-m AZT-33IK telescope (Mondy, Russia) and demonstrated that the purity of these candidates is about 65%. We have discovered one of the most distant (z = 5.08) X-ray selected quasars.

Catalog of 3 < z < 5.5 Quasar Candidates Selected among XMM-Newton Sources and Its Spectroscopic Verification

Directory of Open Access Journals (Sweden)

Georgii Khorunzhev

2017-11-01

Full Text Available We have compiled a catalog of 903 quasar candidates (including known quasars at 3 < z < 5.5 selected among X-ray sources from the XMM-Newton serendipitous survey (3XMM-DR4 catalog. We used photometric SDSS, 2MASS, and WISE data to select the objects. The surface number density of objects in our sample exceeds that in the SDSS spectroscopic quasar sample at the same redshifts by a factor of 1.5. We have performed spectroscopic observations of a subsample of new quasar candidates using a new low- and medium-resolution spectrograph at the 1.6-m AZT-33IK telescope (Mondy, Russia and demonstrated that the purity of these candidates is about 65%. We have discovered one of the most distant (z = 5.08 X-ray selected quasars.

Process performance assessment of advanced anaerobic digestion of sewage sludge including sequential ultrasound-thermal (55 °C) pre-treatment.

Science.gov (United States)

Neumann, Patricio; Barriga, Felipe; Álvarez, Claudia; González, Zenón; Vidal, Gladys

2018-03-15

The aim of this study was to evaluate the performance and digestate quality of advanced anaerobic digestion of sewage sludge including sequential ultrasound-thermal (55 °C) pre-treatment. Both stages of pre-treatment contributed to chemical oxygen demand (COD) solubilization, with an overall factor of 11.4 ± 2.2%. Pre-treatment led to 19.1, 24.0 and 29.9% increased methane yields at 30, 15 and 7.5 days solid retention times (SRT), respectively, without affecting process stability or accumulation of intermediates. Pre-treatment decreased up to 4.2% water recovery from the digestate, but SRT was a more relevant factor controlling dewatering. Advanced digestion showed 2.4-3.1 and 1.5 logarithmic removals of coliforms and coliphages, respectively, and up to a 58% increase in the concentration of inorganics in the digestate solids compared to conventional digestion. The COD balance of the process showed that the observed increase in methane production was proportional to the pre-treatment solubilization efficiency. Copyright © 2018 Elsevier Ltd. All rights reserved.

40 CFR 205.55 - Requirements.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirements. 205.55 Section 205.55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.55 Requirements. ...

27 CFR 18.55 - Label.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Label. 18.55 Section 18.55... TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Operations § 18.55 Label. Each container of concentrate will have affixed thereto, before transfer, a label identifying the product and...

40 CFR 96.55 - Banking.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Banking. 96.55 Section 96.55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NOX BUDGET... Tracking System § 96.55 Banking. (a) NOX allowances may be banked for future use or transfer in a...

39 CFR 3020.55 - Review.

Science.gov (United States)

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Review. 3020.55 Section 3020.55 Postal Service... the Product Lists Described Within the Mail Classification Schedule § 3020.55 Review. The Commission shall review the request, the Postal Service reply, and any public comment to determine whether the...

7 CFR 701.55 - Nursery.

Science.gov (United States)

2010-01-01

... 7 Agriculture 7 2010-01-01 2010-01-01 false Nursery. 701.55 Section 701.55 Agriculture Regulations... ADMINISTERED UNDER THIS PART § 701.55 Nursery. (a) Subject to the other eligibility provisions of this part... under this section for the cost of removing nursery debris such as nursery structures, shade houses, and...

The Work Softening by Deformation-Induced Disordering and Cold Rolling of 6.5 wt pct Si Steel Thin Sheets

Science.gov (United States)

Wang, Xianglong; Li, Haoze; Zhang, Weina; Liu, Zhenyu; Wang, Guodong; Luo, Zhonghan; Zhang, Fengquan

2016-09-01

As-cast strip of 6.5 wt pct Si steel was fabricated by twin-roll strip casting. After hot rolling at 1323 K (1050 °C), thin sheets with the thickness of 0.35 mm were produced by warm rolling at 373 K (100 °C) with rolling reductions of 15, 25, 35, 45, 55, and 65 pct. Influence of warm rolling reduction on ductility was investigated by room temperature bending test. The measurement of macro-hardness showed that "work softening" could begin when the warm rolling reduction exceeded 35 pct. The room temperature ductility of the thin sheets gradually increased with the increase of warm rolling reductions, and the plastic deformation during bending began to form when the warm rolling reduction was greater than 45 pct, the 65 pct rolled thin sheet exhibited the maximum plastic deformation of about 0.6 pct during bending at room temperature, with a few small dimples having been observed on the fracture surfaces. B2-ordered domains were formed in the 15, 25, 35, 45, and 55 pct rolled specimens, and their average size decreased with the increase of warm rolling reductions. By contrast, no B2-ordered domain could be found in the 65 pct rolled specimen. It had been observed that large-ordered domains could be split into several small parts by the slip of partial super-dislocations during warm rolling, which led to significant decrease of the order degree to cause the phenomenon of deformation-induced disordering. On the basis of these results, cold rolling schedule was developed to successfully fabricate 0.25-mm-thick sheets with good surface qualities and magnetic properties from warm rolled sheets.

Konfirmasi spesifitas GAD65 terhadap anti-GAD65 pada tikus DM dan pasien DM tipe 1

Directory of Open Access Journals (Sweden)

Aulanni’a Aulanni’a

2012-02-01

Full Text Available The use of glutamic acid decarboxylase (GAD65 from bovine brain has been studied to obtain basic knowledge and diagnosis and prediction of Type 1 Diabetes Mellitus (DM patients. The importance of GAD65 in DM diagnosis based on its patogenesis. One of the autoimmune marker that can be used to detect beta-pancreas destruction in Diabetes Type I is the antibody to glutamic acid decarboxylase (GAD65. Most of the pre-diabetic patients indicate the reactive autoantibody to GAD65. For early detection of anti-GAD65 in the serum of the patient, human recombinat GAD65 has been succeed to be used. However this is not economical, therefore, it is necessary to find the alternative source of cheaper GAD65. The aim of this research is to develop an early detection kit of Type 1 DM based on antibody- GAD65, since the longest patient suffering from DM has higher probability to be complicated, especially for uncured patients. The anti- GAD65 antibodies induced by anti-GAD65 synthetized and labelled by alkaline phosphatase can be used as reagent detection early DM patients. The ten patients of DM as samples (positive of anti-GAD65 and five rats of DM were positive with western blott technique using reagents as result of this research. It can be concluded, GAD65 enzyme isolated from bovine brain induced anti-GAD65 production and have possibilities to be packaged in a diagnostic kit for patient pre DM.

40 CFR 55.11 - Delegation.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Delegation. 55.11 Section 55.11... CONTINENTAL SHELF AIR REGULATIONS § 55.11 Delegation. (a) The Governor or the Governor's designee of any State... request for delegation within 6 months of the receipt of the request. (d) If the Administrator finds that...

Expression of tumor necrosis factor-alpha and receptor I(P55in pterygium

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Bing Wu

2014-06-01

Full Text Available AIM:To observe the expression of tumor necrosis factor- alpha(TNF-αand its receptor I(P55in different pterygium and discuss the role of TNF-α and receptor I(P55in pterygium.METHODS: Immunohistochemistical staining method(PVwas adopted to detect the expression of TNF-α and receptor I in pterygium(72 eyesand para-pterygium conjunctival tissue(30 eyes. The relationship between the expression and clinical-pathological parameters was also analyzed. RESULTS: The positive rates of TNF-α were 65.3%(47/72, 26.7%(8/30in pterygium and para-pterygium conjunctival tissue. The positive expression of TNF-α had statistic difference between the two groups(χ2=12.706, Pχ2=13.875, Pχ2=6.547, P=0.011. There had no statistically significance of the expression intensity between the two groups(F=1.288, P=0.393; the positive rate in advanced pterygium group was higher than quiescent pterygium group(χ2=4.082, P=0.043. The expression intensity had no statistically significance between the two groups(F=0.489, P=0.708. The positive rate of P55 in recurrent pterygium group was higher than primary pterygium group(χ2=9.907, P=0.002. There had no statistically significance of the two group's expression intensity(F=1.175, P=0.424; the positive rate in advanced pterygium group was higher than in quiescent pterygium group(χ2=11.140, P=0.001. The expression intensity had no statistically significance between the two groups(F=0.665, P=0.621. CONCLUSION:The expression of TNF-α and P55 are changing according to the development of clinical staging and onset. The expression of TNF-α and P55 may be related to clinical classification, staging and patient's working conditions of pterygium. There has no significant difference expression intensity of TNF-α and P55 in clinical staging and onset of pterygium.

Surprisingly different star-spot distributions on the near equal-mass equal-rotation-rate stars in the M dwarf binary GJ 65 AB

Science.gov (United States)

Barnes, J. R.; Jeffers, S. V.; Haswell, C. A.; Jones, H. R. A.; Shulyak, D.; Pavlenko, Ya. V.; Jenkins, J. S.

2017-10-01

We aim to understand how stellar parameters such as mass and rotation impact the distribution of star-spots on the stellar surface. To this purpose, we have used Doppler imaging to reconstruct the surface brightness distributions of three fully convective M dwarfs with similar rotation rates. We secured high cadence spectral time series observations of the 5.5 au separation binary GJ 65, comprising GJ 65A (M5.5V, Prot = 0.24 d) and GJ 65B (M6V, Prot = 0.23 d). We also present new observations of GJ 791.2A (M4.5V, Prot = 0.31 d). Observations of each star were made on two nights with UVES, covering a wavelength range from 0.64 - 1.03μm. The time series spectra reveal multiple line distortions that we interpret as cool star-spots and which are persistent on both nights suggesting stability on the time-scale of 3 d. Spots are recovered with resolutions down to 8.3° at the equator. The global spot distributions for GJ 791.2A are similar to observations made a year earlier. Similar high latitude and circumpolar spot structure is seen on GJ 791.2A and GJ 65A. However, they are surprisingly absent on GJ 65B, which instead reveals more extensive, larger, spots concentrated at intermediate latitudes. All three stars show small amplitude latitude-dependent rotation that is consistent with solid body rotation. We compare our measurements of differential rotation with previous Doppler imaging studies and discuss the results in the wider context of other observational estimates and recent theoretical predictions.

Hubungan Derajat Skor CURB-65 Saat Awal Masuk dan Nilai Antitrombin III pada Pasien Pneumonia Komunitas

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Sari Andriyani

2016-06-01

Full Text Available The assessment of the level of severity in patients with community acquired pneumonia (CAP is very important to determine the next steps in the disease management. Antithrombin III (AT-III is known as one of the coagulation biomarkers that may be useful for predicting the severity of CAP at early admission in hospital. The AT-III is known to be used in diagnosis to help clinicians decide the antibiotic treatment to be given and to make prognosis. The aim of this cross-sectional study was to determine the correlation between confusion, urea, respiratory rate, blood pressure, age >65 years (CURB-65 score and AT-III in CAP patients at early admission in hospital. The method of study . The data were collected in Adam Malik Hospital from February to March 2013. CAP subjects were examined with CURB-65 score, AT-III, other laboratory assessments, sputum, and blood cultures at the early admission in the emergency room and outpatient clinic. The CURB-65 score was correlated with AT-III to determine the prognostic use of AT-III. A total of CAP 55 subjects were assessed with 23 subjects (42% with severe CURB-65 scores (3–5, 17 subjects (31% with moderate scores (2 , and15 subjects (27% with mild scores (0–1. A significant correlation between CURB-65 and AT-III was found through the use of Spearman correlation test (p=0.0001. In conclusion, AT-III is a coagulation biomarker that correlates with the CURB-65 clinical scoring system. AT-III can be used to determine the prognosis in CAP at early admission in hospital.

Photometric Selection of a Massive Galaxy Catalog with z ≥ 0.55

Science.gov (United States)

Núñez, Carolina; Spergel, David N.; Ho, Shirley

2017-02-01

We present the development of a photometrically selected massive galaxy catalog, targeting Luminous Red Galaxies (LRGs) and massive blue galaxies at redshifts of z≥slant 0.55. Massive galaxy candidates are selected using infrared/optical color-color cuts, with optical data from the Sloan Digital Sky Survey (SDSS) and infrared data from “unWISE” forced photometry derived from the Wide-field Infrared Survey Explorer (WISE). The selection method is based on previously developed techniques to select LRGs with z> 0.5, and is optimized using receiver operating characteristic curves. The catalog contains 16,191,145 objects, selected over the full SDSS DR10 footprint. The redshift distribution of the resulting catalog is estimated using spectroscopic redshifts from the DEEP2 Galaxy Redshift Survey and photometric redshifts from COSMOS. Restframe U - B colors from DEEP2 are used to estimate LRG selection efficiency. Using DEEP2, the resulting catalog has an average redshift of z = 0.65, with a standard deviation of σ =2.0, and an average restframe of U-B=1.0, with a standard deviation of σ =0.27. Using COSMOS, the resulting catalog has an average redshift of z = 0.60, with a standard deviation of σ =1.8. We estimate 34 % of the catalog to be blue galaxies with z≥slant 0.55. An estimated 9.6 % of selected objects are blue sources with redshift z0.55. Stellar contamination is estimated to be 1.8%.

7 CFR 65.150 - Goat.

Science.gov (United States)

2010-01-01

..., PORK, LAMB, CHICKEN, GOAT MEAT, PERISHABLE AGRICULTURAL COMMODITIES, MACADAMIA NUTS, PECANS, PEANUTS, AND GINSENG General Provisions Definitions § 65.150 Goat. Goat means meat produced from goats. ... 7 Agriculture 3 2010-01-01 2010-01-01 false Goat. 65.150 Section 65.150 Agriculture Regulations of...

7 CFR 65.190 - Lamb.

Science.gov (United States)

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Lamb. 65.190 Section 65.190 Agriculture Regulations of..., PORK, LAMB, CHICKEN, GOAT MEAT, PERISHABLE AGRICULTURAL COMMODITIES, MACADAMIA NUTS, PECANS, PEANUTS, AND GINSENG General Provisions Definitions § 65.190 Lamb. Lamb means meat produced from sheep. ...

7 CFR 65.120 - Chicken.

Science.gov (United States)

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Chicken. 65.120 Section 65.120 Agriculture Regulations..., PORK, LAMB, CHICKEN, GOAT MEAT, PERISHABLE AGRICULTURAL COMMODITIES, MACADAMIA NUTS, PECANS, PEANUTS, AND GINSENG General Provisions Definitions § 65.120 Chicken. Chicken has the meaning given the term in...

Comparative treatment patterns, healthcare resource utilization and costs of atomoxetine and long-acting methylphenidate among children and adolescents with attention-deficit/hyperactivity disorder in Germany.

Science.gov (United States)

Greven, Peter; Sikirica, Vanja; Chen, Yaozhu J; Curtice, Tammy G; Makin, Charles

2017-09-01

Attention-deficit/hyperactivity disorder (ADHD) imposes a substantial burden on patients and their families. A retrospective, propensity score-matched cohort study compared treatment patterns, healthcare resource utilization (HRU) and costs among children/adolescents with ADHD aged 6-17 years at treatment initiation (index) in Germany who received atomoxetine (ATX) or long-acting methylphenidate (LA-MPH) monotherapy. Patients received at least one prescription for their index medication (ATX/LA-MPH) during 2006-2010; the first prescription marked the index date. ATX- and LA-MPH-indexed cohorts were matched 1:1 (n = 737); a patient subset was identified that had not received ADHD-indicated medications in 12 months prior to index (novel initiators: ATX, n = 486; LA-MPH, n = 488). Treatment patterns were evaluated among novel initiators, and HRU and costs among the matched cohorts in the 12 months after index. No significant differences in baseline characteristics were found between the novel initiator patient subsets. ATX-indexed novel initiators had significantly longer persistence to index medication [mean (standard deviation; SD) days: 222.0 (133.9) vs 203.2 (135.0), P = 0.029) but higher switching rates (8.8 vs 5.5 %, P = 0.045) than LA-MPH-indexed novel initiators. The total ATX-indexed cohort required more prescriptions [any medication; mean (SD): 20.9 (11.5) vs 15.7 (9.0), P < 0.001] and outpatient visits [mean (SD): 10.1 (6.3) vs 8.3 (5.3), P < 0.001], and incurred significantly higher total median healthcare costs (€1144 vs €541, P < 0.001) versus matched LA-MPH patients. These real-world data indicate that, among children/adolescents with ADHD in Germany, ATX-indexed patients may require more prescriptions and physician visits, and incur higher total healthcare costs, than matched LA-MPH patients.

18 CFR 366.4 - FERC-65, notification of holding company status, FERC-65A, exemption notification, and FERC-65B...

Science.gov (United States)

2010-04-01

... meet the definition of a holding company as provided by § 366.1 as of February 8, 2006 shall notify the... of holding company status, FERC-65A, exemption notification, and FERC-65B, waiver notification. 366.4... OF ENERGY REGULATIONS UNDER THE PUBLIC UTILITY HOLDING COMPANY ACT OF 2005, FEDERAL POWER ACT AND...

40 CFR 65.86 - Monitoring.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Monitoring. 65.86 Section 65.86 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Transfer Racks § 65.86 Monitoring. The owner or operator of a transfer rack equipped with...

45 CFR 96.65 - Discovery.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discovery. 96.65 Section 96.65 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Hearing Procedure § 96.65 Discovery. The use of interrogatories, depositions, and other forms of discovery shall not be allowed. ...

28 CFR 90.65 - Evaluation.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Evaluation. 90.65 Section 90.65 Judicial... Cases § 90.65 Evaluation. (a) The National Institute of Justice will conduct evaluations and studies of... with such federally-sponsored research and evaluation studies of their projects. In addition, grant...

21 CFR 820.65 - Traceability.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Traceability. 820.65 Section 820.65 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES QUALITY SYSTEM REGULATION Identification and Traceability § 820.65 Traceability. Each manufacturer of a...

Stapled hemorrhoidopexy: Clinical results of 65 cases

Directory of Open Access Journals (Sweden)

Ahmet Pergel

2012-09-01

Full Text Available Objectives: To present results of our patients underwentstapled hemorrhoidopexy due to hemorrhoidal diseaseand discuss in accompaniment with the literature.Material and methods: The patients, who diagnosed by3rd-4th degree hemorrhoidal disease and underwent hemorrhoidopexywith Longo method between January, 2009and April, 2011, were included. All data were prospectivelycollected and retrospectively examined. The patientswere evaluated in terms of demographic properties, complaintson admission, and postoperative complications.Results: Forty-three (66% of 65 patients were male,22 (34% were female. The mean age was 38±11.9(range:23-76 years. The most frequent complaints werebleeding, swelling, itching, pain, constipation respectively.Third degree hemorrhoid was present in fifty-eight (89%patients, 4th degree hemorrhoid was in 7 (11% patients.The mean operation duration was 37.6±8.1(range:24-55minutes, the mean hospitalization duration was 27±7.8(range:20-76 hours. One or more complication developedin total 17 (26% patients. As complication, bleedingwas determined in 13 (20% patients, pain was in 6 (9%,urinary retention was in 2 (3%, tenesmus was in 3 (5%,external hemorrhoidal thrombosis was in 1 (2%, and recurrencewas in 4 (6%.Conclusions: The patients can return their daily activitiesearly with stapled hemorrhoidopexy because of less painand quick recovery period. We consider that appropriatepatient selection and proper application of the techniqueare important in the success of this method. Particularly in3rd degree hemorrhoidal disease, Longo’s technique canbe suggested as an alternative to classical methods. JClin Exp Invest 2012; 3 (3: 340-344Key words: Hemorrhoidal disease, stapled hemorrhoidopexy,Longo’s procedure

12 CFR 4.65 - Certification.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Certification. 4.65 Section 4.65 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY ORGANIZATION AND FUNCTIONS, AVAILABILITY...; Contracting for Goods and Services § 4.65 Certification. (a) Objective. To preserve the integrity and foster...

7 CFR 65.100 - Act.

Science.gov (United States)

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Act. 65.100 Section 65.100 Agriculture Regulations of... MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) COUNTRY OF ORIGIN LABELING OF BEEF..., AND GINSENG General Provisions Definitions § 65.100 Act. Act means the Agricultural Marketing Act of...

Lidar observation of middle atmospheric gravity wave activity over a southern sub-tropical station, Reunion Island (21°S; 55°E)

CSIR Research Space (South Africa)

Sivakumar, V

2006-07-01

Full Text Available associated with the gravity wave perturbations for different height regions. 36-42 km 45-51 km 54-60 km AO : AMP = 2.0, RMS = 41.2 SAO : AMP = 0.8, RMS = 62.1 AO : AMP = 3.2, RMS = 156.8 SAO : AMP = 3.0, RMS = 354.9 AO : AMP = 1.9, RMS... = 978.9 SAO : AMP = 9.7, RMS = 1700.9 212.1±55.6 52.1±9.9 21.8±3.4 Winter 255.2±93.7 57.3±14.6 22.5±4.9 Summer 233.4±79.6 54.6±12.6 22.1±4.2 Overall 55-65 km45-55 km35-45 kmPotential Energy ( J / kg ) Summer : October to March Winter : April...

Anti-mutated citrullinated vimentin (anti-MCV) and anti-65 kDa heat shock protein (anti-hsp65): new biomarkers in ankylosing spondylitis.

Science.gov (United States)

Bodnár, Nóra; Szekanecz, Zoltán; Prohászka, Zoltán; Kemény-Beke, Adám; Némethné-Gyurcsik, Zsuzsanna; Gulyás, Katalin; Lakos, Gabriella; Sipka, Sándor; Szántó, Sándor

2012-01-01

Citrullination as well as anti-citrullinated protein/peptide antibodies (ACPA) have been implicated in the pathogenesis of rheumatoid arthritis (RA). While ACPAs are specific and sensitive markers for RA, there have been hardly any reports regarding ACPAs in ankylosing spondylitis (AS). The possible role of antibodies to Mycobacterial 65 kDa heat shock protein (hsp65) has not been characterized in AS. As new laboratory biomarkers of AS are needed, we investigated the prevalence of anti-mutated citrullinated vimentin (MCV) and anti-hsp65 antibodies in AS. Altogether 43 AS and 44 healthy controls were included in the study. Anti-MCV and anti-hsp65 were determined in sera by commercial and in-house ELISA, respectively. Serum autoantibody levels were correlated with ESR, CRP, HLA-B27 status, smoking habits, pain intensity, BASDAI, BASFI and BASMI indices. Patients with AS had significantly higher serum anti-MCV levels (17.3 U/mL, range: 8.3-31.5 U/mL) in comparison to healthy subjects (8.9 U/mL, range: 5.4-13.3 U/mL) (p20 U/mL). The mean anti-hsp65 concentration in AS sera was 124.8 AU/mL (range: 27.2-1000 AU/mL), while controls exerted significantly lower anti-hsp65 levels (mean: 51.8 AU/mL; range: 22.5-88.5 AU/mL) (p<0.001). Correlation analysis revealed that both anti-MCV positivity (r=0.613; p=0.012) and absolute serum anti-MCV levels (r=0.553; p=0.021) correlated with anti-hsp65 levels. Anti-MCV positivity also correlated with ESR (r=0.437; p=0.03). Anti-MCV and anti-hsp65 may be novel biomarkers in AS. Copyright © 2011. Published by Elsevier SAS.

42 CFR 55a.107 - What other regulations apply?

Science.gov (United States)

2010-10-01

... FOR BLACK LUNG CLINICS General Provisions § 55a.107 What other regulations apply? Other regulations which apply to the Black Lung Clinics Program include, but are not limited to, the following: 42 CFR...

Broad bandwidth and 600 μm length photonic crystal fiber polarization filter at the communication window of 1.55 μm

Science.gov (United States)

Zhang, Zhen; Li, Shuguang; Liu, Qiang; Zhang, Shuhuan; Wang, Yujun; Wu, Junjun

2018-02-01

A broad bandwidth and 600-μm length photonic crystal fiber polarization filter at the communication window of 1.55 μm is proposed. The physical parameters are analyzed by the finite element method. In the structure, the loss is 705.81 dB/cm for y-polarized mode and 24.06 dB/cm for x-polarized mode at the wavelength of 1.55 μm; the y-polarized mode will be filtered out because of this property. The bandwidth of an extinction ratio (ER) better than -20 dB is 65 nm when the filter length is 600 μm, and the ER is -41 dB at the communication wavelength of 1.55 μm. The filter structure is simple and easy to produce, and it can be used to produce a single-polarization filter.

47 CFR 65.500 - Net income.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Net income. 65.500 Section 65.500... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Interexchange Carriers § 65.500 Net income. The net income methodology specified in § 65.450 shall be utilized by all interexchange carriers that are...

7 CFR 1700.55 - Telecommunications Program.

Science.gov (United States)

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Telecommunications Program. 1700.55 Section 1700.55... AGRICULTURE GENERAL INFORMATION Loan and Grant Approval Authorities § 1700.55 Telecommunications Program. (a..., Telecommunications Program, has the authority to approve the following loans, loan guarantees, and lien...

46 CFR 503.55 - Derivative classification.

Science.gov (United States)

2010-10-01

... Security Program § 503.55 Derivative classification. (a) In accordance with Part 2 of Executive Order 12958 and directives of the Information Security Oversight Office, the incorporation, paraphrasing... 46 Shipping 9 2010-10-01 2010-10-01 false Derivative classification. 503.55 Section 503.55...

10 CFR 36.55 - Personnel monitoring.

Science.gov (United States)

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Personnel monitoring. 36.55 Section 36.55 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR IRRADIATORS Operation of Irradiators § 36.55 Personnel monitoring. (a) Irradiator operators shall wear a personnel dosimeter that is...

7 CFR 52.55 - Political activity.

Science.gov (United States)

2010-01-01

..., to take an active part in political management or in political campaigns. Political activities in... 7 Agriculture 2 2010-01-01 2010-01-01 false Political activity. 52.55 Section 52.55 Agriculture... Regulations Governing Inspection and Certification Miscellaneous § 52.55 Political activity. All inspectors...

7 CFR 3430.55 - Technical reporting.

Science.gov (United States)

2010-01-01

... required to submit other technical reports or submit the CRIS reports more frequently than annually... 7 Agriculture 15 2010-01-01 2010-01-01 false Technical reporting. 3430.55 Section 3430.55... ASSISTANCE PROGRAMS-GENERAL AWARD ADMINISTRATIVE PROVISIONS Post-Award and Closeout § 3430.55 Technical...

Health screenings for women over age 65

Science.gov (United States)

Health maintenance visit - women - over age 65; Physical exam - women - over age 65; Yearly exam - women - over age 65; Checkup - women - over age 65; Women's health - over age 65; Preventive care exam - women - over ...

Health screenings for men over age 65

Science.gov (United States)

Health maintenance visit - men - over age 65; Physical exam - men - over age 65; Yearly exam - men - over age 65; Checkup - men - over age 65; Men's health - over age 65; Preventive care exam - men - over ...

Expression of Aspergillus niger N5-5 in E. coli and purification and identification of products.

Science.gov (United States)

Zhang, Shuai; Cao, Yong; Cheng, Hao

2017-12-01

Due to the feature of high hydrolysis, tannase is widely used in food, beverage, brewing and other fields. However, high cost in producing natural tannase makes it difficult to apply tannase to industry in a large-scale. Microbial expression systems can be used for preparing numerous amount of enzyme at low cost, so in this paper Aspergillus niger N5-5 was expressed using E. coli system. Specific primers were designed based on the Aspergillus niger N5-5 sequence N3 (GenBank, No.: KP677552), and tannase gene tan was promoted to carry 6 His tag and enzyme cutting site which contains NdeI/HindIII using PCR amplification. Then, tannase gene tan was connected to expression vector by NdeI/HindIII enzyme cutting. In this way, recombinant expression vector tan -pET43.1a was formed. Then, the expression vector pET43.1a by NdeI/HindIII enzyme cutting was transformed into E. coli BL21 (DE3) to induce expression of Aspergillus niger N5-5. When the induced fungi were disrupted by the ultrasonic wave, the crude enzyme was extracted and purified by using the IMAC, and then the activity of the crude enzyme and pure enzyme was determined. According to the results of determination of the tannase activity, the tannase activity of the crude enzyme was greatly improved after the crude enzyme was purified, and the specific activity of the pure enzyme was about 8 times of that of the crude enzyme. The results of SDS-PAGE of the pure enzyme showed that the molecular mass of the pure enzyme was about 65 kDa/64-65 kDa, which was consistent with the expected result (64.2 kDa), It can be concluded that the crude enzyme solution was purified successfully. The results of pure enzyme's protein identification by Western Blotting showed that clear protein bands pro -3 were observed. Molecular mass of clear protein bands pro-3 was about 65 kDa, which was in line with the expected results (64.2 kDa). It can be seen that the aforementioned expression protein could be specifically combined

32 CFR 536.55 - Structured settlements.

Science.gov (United States)

2010-07-01

... 32 National Defense 3 2010-07-01 2010-07-01 true Structured settlements. 536.55 Section 536.55... AGAINST THE UNITED STATES Investigation and Processing of Claims § 536.55 Structured settlements. (a) The... of this part, structured settlements cannot be required but are encouraged in situations listed above...

12 CFR 313.55 - Salary adjustments.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Salary adjustments. 313.55 Section 313.55 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE PROCEDURES FOR CORPORATE DEBT COLLECTION Salary Offset § 313.55 Salary adjustments. Any negative adjustment to pay arising...

14 CFR 437.55 - Hazard analysis.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Hazard analysis. 437.55 Section 437.55... TRANSPORTATION LICENSING EXPERIMENTAL PERMITS Safety Requirements § 437.55 Hazard analysis. (a) A permittee must... safety of property resulting from each permitted flight. This hazard analysis must— (1) Identify and...

High-speed 1.3 -1.55 um InGaAs/InP PIN photodetector for microwave photonics

Science.gov (United States)

Kozyreva, O. A.; Solov'ev, Y. V.; Polukhin, I. S.; Mikhailov, A. K.; Mikhailovskiy, G. A.; Odnoblyudov, M. A.; Gareev, E. Z.; Kolodeznyi, E. S.; Novikov, I. I.; Karachinsky, L. Ya; Egorov, A. Yu; Bougrov, V. E.

2017-11-01

We have fabricated the 1.3-1.55 um PIN photodetector based on InGaAs/InP heterostructure. Measurement results of optical and electrical characteristics of PIN photodetector chip were the following: photoconductivity at 1550 nm was 0.65 A/W and internal capacitance was 0.025 pF. Microwave model of photodetector was developed and verified by measurements of scattering matrix. The implementation of broadband (up to 20 GHz) hybrid integrated matching and biasing circuit for high-speed photodetector is presented.

10 CFR 55.21 - Medical examination.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Medical examination. 55.21 Section 55.21 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Medical Requirements § 55.21 Medical examination. An applicant for a license shall have a medical examination by a physician. A licensee shall have a medical...

49 CFR 1242.82 - Other and casualties and insurance (accounts XX-55-99 and 50-55-00).

Science.gov (United States)

2010-10-01

... 49 Transportation 9 2010-10-01 2010-10-01 false Other and casualties and insurance (accounts XX-55... RAILROADS 1 Operating Expenses-Transportation § 1242.82 Other and casualties and insurance (accounts XX-55... separation of administration (account XX-55-01). Operating Expenses general and administration ...

7 CFR 1724.55 - Dam safety.

Science.gov (United States)

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Dam safety. 1724.55 Section 1724.55 Agriculture... § 1724.55 Dam safety. (a) The provisions of this section apply only to RUS financed electric system... for Dam Safety,”(Guidelines), as applicable. A dam, as more fully defined in the Guidelines, is...

10 CFR 30.55 - Tritium reports.

Science.gov (United States)

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Tritium reports. 30.55 Section 30.55 Energy NUCLEAR..., Inspections, Tests, and Reports § 30.55 Tritium reports. (a)-(b) [Reserved] (c) Except as specified in paragraph (d) of this section, each licensee who is authorized to possess tritium shall report promptly to...

CSIR Annual report 1954-55

CSIR Research Space (South Africa)

CSIR

1955-01-01

Full Text Available stream_source_info Annual Report_1954-55.pdf.txt stream_content_type text/plain stream_size 206 Content-Encoding ISO-8859-1 stream_name Annual Report_1954-55.pdf.txt Content-Type text/plain; charset=ISO-8859-1 ...

NMR studies of 55Mn in amorphous CexMn100-x alloys

International Nuclear Information System (INIS)

Niki, H.; Okamura, K.; Yogi, M.; Amakai, Y.; Takano, H.; Murayama, S.; Obi, Y.

2008-01-01

In order to investigate the heavy-fermion like behavior of amorphous alloy Ce x Mn 100-x , the NMR measurements of 55 Mn (I=5/2 ) in Ce 65 Mn 35 have been carried out from 4.2 to 270 K using powdered sample. A broadened NMR spectrum containing five NQR lines split due to NQR interaction is observed. Quadrupole coupling constant 3e 2 Qq/2I(2I-1)h is gradually changed from about 1.8 MHz at 4.2 K to about 1.6 MHz at 270 K. Temperature dependence of the line width is expressed in the Curie-Weiss law with θ p =-10.5K. The value of Knight shift would be almost constant from 4.2 to 270 K

Methylphenidate and Memory and Attention Adaptation Training for Persistent Cognitive Symptoms after Traumatic Brain Injury: A Randomized, Placebo-Controlled Trial.

Science.gov (United States)

McDonald, Brenna C; Flashman, Laura A; Arciniegas, David B; Ferguson, Robert J; Xing, Li; Harezlak, Jaroslaw; Sprehn, Gwen C; Hammond, Flora M; Maerlender, Arthur C; Kruck, Carrie L; Gillock, Karen L; Frey, Kim; Wall, Rachel N; Saykin, Andrew J; McAllister, Thomas W

2017-08-01

The purpose of this multicenter, prospective, randomized, placebo-controlled study was to evaluate and compare the efficacy of two cognitive rehabilitation interventions (Memory and Attention Adaptation Training (MAAT) and Attention Builders Training (ABT)), with and without pharmacological enhancement (ie, with methylphenidate (MPH) or placebo), for treating persistent cognitive problems after traumatic brain injury (TBI). Adults with a history of TBI at least 4 months before study enrollment with either objective cognitive deficits or subjective cognitive complaints were randomized to receive MPH or placebo and MAAT or ABT, yielding four treatment combinations: MAAT/MPH (N=17), ABT/MPH (N=19), MAAT/placebo (N=17), and ABT/placebo (N=18). Assessments were conducted pre-treatment (baseline) and after 6 weeks of treatment (post treatment). Outcome measures included scores on neuropsychological measures and subjective rating scales. Statistical analyses used linear regression models to predict post-treatment scores for each outcome variable by treatment type, adjusting for relevant covariates. Statistically significant (PABT/placebo), nonverbal learning (MAAT/MPH>MAAT/placebo and MAAT/MPH>ABT/MPH), and auditory working memory and divided attention (MAAT/MPH>ABT/MPH). These results suggest that combined treatment with metacognitive rehabilitation (MAAT) and pharmacotherapy (MPH) can improve aspects of attention, episodic and working memory, and executive functioning after TBI.

42 CFR 55a.101 - Definitions.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Definitions. 55a.101 Section 55a.101 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS PROGRAM GRANTS FOR BLACK LUNG CLINICS General Provisions § 55a.101 Definitions. Act, as used in this part, means the Federal Mine Safety...

28 CFR 345.55 - Longevity pay.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Longevity pay. 345.55 Section 345.55... (FPI) INMATE WORK PROGRAMS Inmate Pay and Benefits § 345.55 Longevity pay. (a) Except as provided in paragraph (b) of this section, an inmate earns longevity pay raises after 18 months spent in FPI work status...

36 CFR 5.5 - Commercial photography.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Commercial photography. 5.5 Section 5.5 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR COMMERCIAL AND PRIVATE OPERATIONS § 5.5 Commercial photography. (a) Motion pictures, television. Before any motion picture may be filmed or any...

40 CFR 279.55 - Analysis plan.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Analysis plan. 279.55 Section 279.55... THE MANAGEMENT OF USED OIL Standards for Used Oil Processors and Re-Refiners § 279.55 Analysis plan... analysis plan describing the procedures that will be used to comply with the analysis requirements of § 279...

10 CFR 1003.55 - OHA evaluation.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false OHA evaluation. 1003.55 Section 1003.55 Energy DEPARTMENT... Rescission § 1003.55 OHA evaluation. (a)(1) The OHA may initiate an investigation of any statement in an application and utilize in its evaluation any relevant facts obtained by such investigation. The OHA may...

Transperitoneal laparoscopic pyeloplasty: Brazilian initial experience with 55 cases

Directory of Open Access Journals (Sweden)

Marco T. C. Lasmar

2010-12-01

Full Text Available PURPOSE: To evaluate prospectively the results obtained in 55 patients undergoing laparoscopic pyeloplasty through transperitoneal access. MATERIALS AND METHODS: From January 2005 to July 2009, fifty-five patients between 13 and 64 years old, were treated for ureteropelvic junction (UPJ stenosis via a transperitoneal laparoscopy. All patients had clinical symptoms of high urinary obstruction and hydronephrosis confirmed by imaging methods. Anderson-Hynes dismembered pyeloplasty was performed in 51 patients and Fenger technique in the other 4 cases. Patients were clinically and imaging evaluated in the postoperative period at 3 and 6 months and then followed-up annually. RESULTS: The operative time ranged from 95 to 270 min. The mean hospital stay was 2 days. The average blood loss was 170 mL. The time to return to normal activities ranged from 10 to 28 days. Anomalous vessels were identified in 27 patients, intrinsic stenosis in 23 patients and 5 patients had high implantation of the ureter. Laparoscopic pyelolithotomy was successfully performed in 6 patients with associated renal stones. That series monitoring ranged from 1 to 55 months. One patient had longer urinary fistula (11 days, 3 patients had portal infection and 6 patients had prolonged ileus. There was one conversion due to technical difficulties. From the later postoperative complications, 2 patients had re-stenosis, one determined by Anderson-Hynes technique and the other by Fenger technique. The success rate was 95.65%. CONCLUSIONS: Laparoscopic pyeloplasty has functional results comparable to conventional open technique. It offers less morbidity, with aesthetic and post-operative convalescence benefits and lower complication rates.

34 CFR 668.55 - Updating information.

Science.gov (United States)

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false Updating information. 668.55 Section 668.55 Education... Information § 668.55 Updating information. (a)(1) Unless the provisions of paragraph (a)(2) or (a)(3) of this... applicant to verify the information contained in his or her application for assistance in an award year if...

7 CFR 65.255 - United States.

Science.gov (United States)

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false United States. 65.255 Section 65.255 Agriculture..., PEANUTS, AND GINSENG General Provisions Definitions § 65.255 United States. United States means the 50... United States. ...

Metabolism and binding to DNA of a novel hepatocarcinogen: methapyrilene

International Nuclear Information System (INIS)

Lampe, M.A.

1987-01-01

The purpose of this study was to characterize the metabolism and macromolecular binding of [ 14 C]-MPH. When rats were treated for up to sixteen weeks with 1000 ppm MPH, they excreted at least six MPH related compounds in their urine including 2-hydroxymethyl-thiophene, N-2-pyridyl-N'-dimethylethylenediamine, (5-hydroxypyridyl)methapyrilene, (5-hydroxypyridyl)N-2-pyridyl-N'-dimethylethylenediamine and MPH. In vitro metabolism is also affected by chronic treatment of rats with MPH, with the most remarkable change observed being an increase in the mass balance to approximately 100% after 8 or 16 weeks pretreatment. Metabolism of MPH by rat liver microsomes is dependent on the activity of cytochrome P-450 enzymes, as metabolism in vitro was inhibited by the addition 2,4-dichloro-6-phenylphenoxyethylamine (DPEA) and 2-diethylaminoethyl-2,2-diphenylvalerate (SKF-525A). Treatment of rats with phenobarbital or 3-methylcholanthrene induced metabolism of MPH while pretreatment of rats with isosafole or pregnenolone-16α-carbonitrile had a more selective effect on MPH metabolism, and only increased the formation of methapyrilene-amide

7 CFR 946.55 - Safeguards.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Safeguards. 946.55 Section 946.55 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... channels of trade and other outlets for other than the specific purposes authorized therefor, and the...

7 CFR 1412.55 - Provisions relating to tenants and sharecroppers.

Science.gov (United States)

2010-01-01

...-CYCLICAL PROGRAM AND AVERAGE CROP REVENUE ELECTION PROGRAM FOR THE 2008 AND SUBSEQUENT CROP YEARS Financial Considerations Including Sharing Payments § 1412.55 Provisions relating to tenants and sharecroppers. (a) Neither...

7 CFR 947.55 - Safeguards.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Safeguards. 947.55 Section 947.55 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... safeguards to prevent shipments pursuant to § 947.54 from entering channels of trade and other outlets for...

40 CFR 97.55 - Banking.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Banking. 97.55 Section 97.55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) FEDERAL NOX... Banking. NOX allowances may be banked for future use or transfer in a compliance account, an overdraft...

CMOS-NEMS Copper Switches Monolithically Integrated Using a 65 nm CMOS Technology

Directory of Open Access Journals (Sweden)

Jose Luis Muñoz-Gamarra

2016-02-01

Full Text Available This work demonstrates the feasibility to obtain copper nanoelectromechanical (NEMS relays using a commercial complementary metal oxide semiconductor (CMOS technology (ST 65 nm following an intra CMOS-MEMS approach. We report experimental demonstration of contact-mode nano-electromechanical switches obtaining low operating voltage (5.5 V, good ION/IOFF (103 ratio, abrupt subthreshold swing (4.3 mV/decade and minimum dimensions (3.50 μm × 100 nm × 180 nm, and gap of 100 nm. With these dimensions, the operable Cell area of the switch will be 3.5 μm (length × 0.2 μm (100 nm width + 100 nm gap = 0.7 μm2 which is the smallest reported one using a top-down fabrication approach.

The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder

International Nuclear Information System (INIS)

Szobot, Claudia M.; Ketzer, Carla; Kapczinski, Flavio; Cunha, Renato D.; Parente, Maria A.; Langleben, Daniel D.; Acton, Paul D.; Rohde, Luis A.P.

2003-01-01

Methylphenidate (MPH) is the most commonly prescribed treatment for attention-deficit/hyperactivity disorder (ADHD). The therapeutic mechanisms of MPH are not, however, fully understood. We studied the effects of MPH on brain activity in male children and adolescents with ADHD, using the blood flow radiotracer technetium-99m ethyl cysteinate dimer ( 99m Tc-ECD) and single-photon emission tomography (SPET). The study was randomized, double blind, and placebo controlled (MPH group, n=19; placebo group, n=17), Radiotracer was administered during the performance of the Continuous Performance Test and before and after 4 days of MPH treatment. Statistical parametric mapping (SPM99) analysis showed a significant reduction in regional cerebral blood flow in the left parietal region in the MPH group compared with the placebo group (P<0.05, corrected for multiple comparisons). Our findings suggest that the posterior attentional system, which includes the parietal cortex, may have a role in the mediation of the therapeutic effects of MPH in ADHD. (orig.)

The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder

Energy Technology Data Exchange (ETDEWEB)

Szobot, Claudia M; Ketzer, Carla; Kapczinski, Flavio [Department of Psychiatry, Federal University of Rio Grande do Sul (Brazil); Cunha, Renato D [Service of Nuclear Medicine, Hospital de Clinicas de Porto Alegre (Brazil); Parente, Maria A [Department of Psychology, Federal University of Rio Grande do Sul (Brazil); Langleben, Daniel D [Department of Psychiatry, University of Pennsylvania (United States); Acton, Paul D [Department of Radiology, University of Pennsylvania (United States); Rohde, Luis A.P. [Department of Psychiatry, Federal University of Rio Grande do Sul (Brazil); Servico de Psiquiatria da Infancia e Adolescencia, Hospital de Clinicas de Porto Alegre (HCPA), Rua Ramiro Barcelos 2350, CEP 90035-003, RS Porto Alegre (Brazil)

2003-03-01

Methylphenidate (MPH) is the most commonly prescribed treatment for attention-deficit/hyperactivity disorder (ADHD). The therapeutic mechanisms of MPH are not, however, fully understood. We studied the effects of MPH on brain activity in male children and adolescents with ADHD, using the blood flow radiotracer technetium-99m ethyl cysteinate dimer ({sup 99m}Tc-ECD) and single-photon emission tomography (SPET). The study was randomized, double blind, and placebo controlled (MPH group, n=19; placebo group, n=17), Radiotracer was administered during the performance of the Continuous Performance Test and before and after 4 days of MPH treatment. Statistical parametric mapping (SPM99) analysis showed a significant reduction in regional cerebral blood flow in the left parietal region in the MPH group compared with the placebo group (P<0.05, corrected for multiple comparisons). Our findings suggest that the posterior attentional system, which includes the parietal cortex, may have a role in the mediation of the therapeutic effects of MPH in ADHD. (orig.)

Mdr65 decreases toxicity of multiple insecticides in Drosophila melanogaster.

Science.gov (United States)

Sun, Haina; Buchon, Nicolas; Scott, Jeffrey G

2017-10-01

ABC transporters are ubiquitous membrane-bound proteins, present in both prokaryotes and eukaryotes. The major function of eukaryotic ABC transporters is to mediate the efflux of a variety of substrates (including xenobiotics) out of cells. ABC transporters have been widely investigated in humans, particularly for their involvement in multidrug resistance (MDR). Considerably less is known about their roles in transport and/or excretion in insects. ABC transporters are only known to function as exporters in insects. Drosophila melanogaster has 56 ABC transporter genes, including eight which are phylogenetically most similar to the human Mdr genes (ABCB1 clade). We investigated the role of ABC transporters in the ABCB1 clade in modulating the susceptibility to insecticides. We took advantage of the GAL4/UAS system in D. melanogaster to knockdown the expression levels of Mdr65, Mdr50, Mdr49 and ABCB6 using transgenic UAS-RNAi lines and conditional driver lines. The most notable effects were increased sensitivities to nine different insecticides by silencing of Mdr65. Furthermore, a null mutation of Mdr65 decreased the malathion, malaoxon and fipronil LC 50 values by a factor of 1.9, 2.1 and 3.9, respectively. Altogether, this data demonstrates the critical role of ABC transporters, particularly Mdr65, in altering the toxicity of specific, structurally diverse, insecticides in D. melanogaster. Copyright © 2017 Elsevier Ltd. All rights reserved.

Investigation of 65Cu by means of the average resonance proton capture method

International Nuclear Information System (INIS)

Erlandsson, B.; Nilsson, K.; Piotrowski, J.

1979-01-01

The 64 Ni(p,γ) 65 Cu reaction has been studied in the proton energy range E sub(p) = 2.05 - 2.55 MeV. The gamma-ray spectra were recorded with a three-crystal pair spectrometer at proton energy differences of 19 keV covering the proton energy range. An average gamma-ray spectrum was formed by adding all the individual spectra after proper adjustment as a result of the alterations in proton energy. The intensities of the gamma rays to final states with known J sup(π)-values were tested against theoretical calculations based on the Hauser-Feshbach theory with good results and these made it possible to deduce further J sup(π)-values. (author)

7 CFR 65.160 - Ground chicken.

Science.gov (United States)

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Ground chicken. 65.160 Section 65.160 Agriculture... OF BEEF, PORK, LAMB, CHICKEN, GOAT MEAT, PERISHABLE AGRICULTURAL COMMODITIES, MACADAMIA NUTS, PECANS, PEANUTS, AND GINSENG General Provisions Definitions § 65.160 Ground chicken. Ground chicken means...

45 CFR 2400.65 - Teaching obligation.

Science.gov (United States)

2010-10-01

... FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Special Conditions § 2400.65 Teaching obligation. Upon receiving a Master's degree, each Fellow must teach American history, American government, social studies, or... 45 Public Welfare 4 2010-10-01 2010-10-01 false Teaching obligation. 2400.65 Section 2400.65...

7 CFR 65.230 - Production step.

Science.gov (United States)

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Production step. 65.230 Section 65.230 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards..., PEANUTS, AND GINSENG General Provisions Definitions § 65.230 Production step. Production step means, in...

47 CFR 65.800 - Rate base.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Rate base. 65.800 Section 65.800 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) INTERSTATE RATE OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Rate Base § 65.800 Rate base. The rate base shall...

21 CFR 660.55 - Labeling.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Labeling. 660.55 Section 660.55 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS ADDITIONAL... name such as polyspecific may appear in smaller type. (4) Visual inspection. When the label has been...

42 CFR 408.65 - Payment options.

Science.gov (United States)

2010-10-01

... 42 Public Health 2 2010-10-01 2010-10-01 false Payment options. 408.65 Section 408.65 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PREMIUMS FOR SUPPLEMENTARY MEDICAL INSURANCE Direct Remittance: Individual Payment § 408.65 Payment options...

7 CFR 65.170 - Ground lamb.

Science.gov (United States)

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Ground lamb. 65.170 Section 65.170 Agriculture... OF BEEF, PORK, LAMB, CHICKEN, GOAT MEAT, PERISHABLE AGRICULTURAL COMMODITIES, MACADAMIA NUTS, PECANS, PEANUTS, AND GINSENG General Provisions Definitions § 65.170 Ground lamb. Ground lamb means comminuted...

47 CFR 65.450 - Net income.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Net income. 65.450 Section 65.450... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Exchange Carriers § 65.450 Net income. (a) Net income shall consist of all revenues derived from the provision of interstate telecommunications services...

7 CFR 65.165 - Ground goat.

Science.gov (United States)

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Ground goat. 65.165 Section 65.165 Agriculture... OF BEEF, PORK, LAMB, CHICKEN, GOAT MEAT, PERISHABLE AGRICULTURAL COMMODITIES, MACADAMIA NUTS, PECANS, PEANUTS, AND GINSENG General Provisions Definitions § 65.165 Ground goat. Ground goat means comminuted...

IAU Commission 55: Communicating Astronomy with the Public

Science.gov (United States)

Fienberg, R. T.; Christensen, L. L.; Russo, P.

2014-01-01

The International Astronomical Union (IAU) has vested considerable responsibility for its public outreach efforts in Commission 55 (C55), Communicating Astronomy with the Public. This article briefly recounts the origin and history of C55 over the past decade, describing how C55 fits into the IAU's recently revised organisational structure and newly implemented Strategic Plan. It also lists C55's current officers, Organising Committee members, Working Groups, and Working Group chairs and explains how IAU members can join C55, inviting other professionals engaged in astronomy-related public outreach to become associates of C55.

21 CFR 173.55 - Polyvinylpyrrolidone.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Polyvinylpyrrolidone. 173.55 Section 173.55 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR... a residual level not to exceed 40 parts per million. Wine As a clarifying agent, at a residual level...

47 CFR 65.304 - Capital structure.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Capital structure. 65.304 Section 65.304... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Exchange Carriers § 65.304 Capital structure. The proportion of each cost of capital component in the capital structure is equal to: Proportion in the capital...

46 CFR 46.10-65 - Construction.

Science.gov (United States)

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Construction. 46.10-65 Section 46.10-65 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES SUBDIVISION LOAD LINES FOR PASSENGER VESSELS Administration § 46.10-65 Construction. (a) The watertight subdivision of every passenger vessel...

32 CFR 552.65 - Command supervision.

Science.gov (United States)

2010-07-01

... 32 National Defense 3 2010-07-01 2010-07-01 true Command supervision. 552.65 Section 552.65 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Solicitation on Military Reservations § 552.65 Command supervision. (a) All insurance...

Preliminary design and economic investigations of Diffuser-Augmented Wind Turbines (DAWT)

Energy Technology Data Exchange (ETDEWEB)

Foreman, K.M.

1981-12-01

A preferred design and configuration approach is suggested for the DAWT innovative wind energy conversion system. A preliminary economic asessment is made for limited production rates of units between 5 and 150 kw rated output. Nine point designs are used to arrive at the conclusions regarding best construction material for the diffuser and busbar cost of electricity (COE). It is estimated that for farm and REA cooperative end users, the COE can range between 2 and 3.5 cents/kWh for sites with annual average wind speeds of 16 and 12 mph (25.7 and 19.3 km/h) respectively, and 150 kW rated units. No tax credits are included in these COE figures. For commercial end users of these 150 kW units the COE ranges between 4.0 and 6.5 cents/kWh for 16 and 12 mph sites. These estimates in 1979 dollars are lower than DOE goals set in 1978 for the rating size and end applications. Recommendations are made for future activities to maintain steady, systematic progress toward mature development of the DAWT.

10 CFR 39.65 - Personnel monitoring.

Science.gov (United States)

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Personnel monitoring. 39.65 Section 39.65 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR WELL LOGGING Radiation Safety Requirements § 39.65 Personnel monitoring. (a) The licensee may not permit an individual to act as a logging...

7 CFR 953.65 - Effective time.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Effective time. 953.65 Section 953.65 Agriculture... STATES Order Regulating Handling Effective Time and Termination § 953.65 Effective time. The provisions of this subpart shall become effective at such time as the Secretary may declare above his signature...

42 CFR 483.65 - Infection control.

Science.gov (United States)

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Infection control. 483.65 Section 483.65 Public... Care Facilities § 483.65 Infection control. The facility must establish and maintain an infection control program designed to provide a safe, sanitary, and comfortable environment and to help prevent the...

Data Quality and Reliability Analysis of U.S. Marine Corps Ground Vehicle Maintenance Records

Science.gov (United States)

2015-06-01

operate in climates 6 ranging from -50 degrees Fahrenheit to 125 degrees Fahrenheit . The MTVR is able to travel at 65mph on improved roads and has...its treatment in the paragraphs below. The MIMMS data comprise 451 distinct UICs. In order to reduce the number of categorical variables within the

Results from utility wind resource assessment programs in Nebraska, Colorado, and Arizona

Energy Technology Data Exchange (ETDEWEB)

Drapeau, C.L. [Global Energy Concepts, Inc., Bothell, WA (United States)

1997-12-31

Global Energy Concepts (GEC) has been retained by utilities in Colorado, Nebraska, and Arizona to site, install, and operate 21 wind monitoring stations as part of the Utility Wind Resource Assessment Program (U*WRAP). Preliminary results indicate wind speed averages at 40 meters (132 ft) of 6.5 - 7.4 m/s (14.5-16.5 mph) in Nebraska and 7.6 - 8.9 m/s (17.0-19.9 mph) in Colorado. The Arizona stations are not yet operational. This paper presents the history and current status of the 21 monitoring stations as well as preliminary data results. Information on wind speeds, wind direction, turbulence intensity, wind shear, frequency distribution, and data recovery rates are provided.

9 CFR 3.65 - Terminal facilities.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Terminal facilities. 3.65 Section 3.65... Transportation Standards § 3.65 Terminal facilities. No person subject to the Animal Welfare regulations shall commingle shipments of live rabbits with inanimate cargo. All animal holding areas of a terminal facility...

TRIM65 negatively regulates p53 through ubiquitination

Energy Technology Data Exchange (ETDEWEB)

Li, Yang [Department of Respiration, The First Hospital of Jilin University, Changchun 130021 (China); Ma, Chengyuan [Department of Neurosurgery, The First Hospital of Jilin University, Changchun 130021 (China); Zhou, Tong [Department of Endocrinology, The First Hospital of Jilin University, Changchun 130021 (China); Liu, Ying [Department of Respiration, The First Hospital of Jilin University, Changchun 130021 (China); Sun, Luyao [Department of Infectious Diseases, The First Hospital of Jilin University, Changchun 130021 (China); Yu, Zhenxiang, E-mail: zhenxiangyu2015@gmail.com [Department of Respiration, The First Hospital of Jilin University, Changchun 130021 (China)

2016-04-22

Tripartite-motif protein family member 65 (TRIM65) is an important protein involved in white matter lesion. However, the role of TRIM65 in human cancer remains less understood. Through the Cancer Genome Atlas (TCGA) gene alteration database, we found that TRIM65 is upregulated in a significant portion of non-small cell lung carcinoma (NSCLC) patients. Our cell growth assay revealed that TRIM65 overexpression promotes cell proliferation, while knockdown of TRIM65 displays opposite effect. Mechanistically, TRIM65 binds to p53, one of the most critical tumor suppressors, and serves as an E3 ligase toward p53. Consequently, TRIM65 inactivates p53 through facilitating p53 poly-ubiquitination and proteasome-mediated degradation. Notably, chemotherapeutic reagent cisplatin induction of p53 is markedly attenuated in response to ectopic expression of TRIM65. Cell growth inhibition by TRIM65 knockdown is more significant in p53 positive H460 than p53 negative H1299 cells, and knockdown of p53 in H460 cells also shows compromised cell growth inhibition by TRIM65 knockdown, indicating that p53 is required, at least in part, for TRIM65 function. Our findings demonstrate TRIM65 as a potential oncogenic protein, highly likely through p53 inactivation, and provide insight into development of novel approaches targeting TRIM65 for NSCLC treatment, and also overcoming chemotherapy resistance. - Highlights: • TRIM65 expression is elevated in NSCLC. • TRIM65 inactivates p53 through mediating p53 ubiquitination and degradation. • TRIM65 attenuates the response of NSCLC cells to cisplatin.

Economic Analysis. Volume V. Course Segments 65-79.

Science.gov (United States)

Sterling Inst., Washington, DC. Educational Technology Center.

The fifth volume of the multimedia, individualized course in economic analysis produced for the United States Naval Academy covers segments 65-79 of the course. Included in the volume are discussions of monopoly markets, monopolistic competition, oligopoly markets, and the theory of factor demand and supply. Other segments of the course, the…

28 CFR 65.51 - Recordkeeping.

Science.gov (United States)

2010-07-01

... examination, to any books, documents, and records of recipients of Federal law enforcement assistance provided... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Recordkeeping. 65.51 Section 65.51 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) EMERGENCY FEDERAL LAW ENFORCEMENT ASSISTANCE...

40 CFR 407.65 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 407.65 Section 407.65 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED FRUITS AND VEGETABLES PROCESSING POINT SOURCE CATEGORY Canned and Preserved Fruits...

Differences in abuse potential of ADHD drugs measured by contrasting poison centre and therapeutic use data.

Science.gov (United States)

Jensen, Louise Schow; Pagsberg, Anne Katrine; Dalhoff, Kim Peder

2015-05-01

Atomoxetine (ATX) is the treatment of choice for attention deficit hyperactivity disorders with co-morbid risk of drug abuse, although its abuse potential needs to be qualified. The purpose of this study is to analyse ATX misuse in relation to therapeutic use and compare our results with that of methylphenidate (MPH). Data on enquiries were extracted from the Danish Poison Information Centre database (January 2006 to June 2012), while data on therapeutic use were provided by the Danish State Serum Institute (2007-2011). The study included 28 ATX and 394 MPH enquiries. Frequency of ATX enquiries did not show a significant correlation to either sale or number of treated patients but for MPH, both correlations were significant (p = 0.001 and p = 0.0008, respectively). The enquiries/number of treated patients relationship differed significantly between ATX and MPH (p = 0.018), but not the enquiries/sale relationship. The proportion of exposures motivated by recreational drug use was significantly lower for ATX (19%) than that for MPH (40%) (p = 0.038). These results suggest that ATX is used by adults for non-medical purposes including recreational use, but to a lesser extent than MPH.

40 CFR 205.55-1 - General requirements.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false General requirements. 205.55-1 Section 205.55-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.55-1 General...

40 CFR 205.55-4 - Labeling-compliance.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Labeling-compliance. 205.55-4 Section 205.55-4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.55-4 Labeling...

40 CFR 205.55-3 - Configuration identification.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Configuration identification. 205.55-3 Section 205.55-3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.55-3 Configuration...

Plasma methylphenidate concentrations in youths treated with high-dose osmotic release oral system formulation.

Science.gov (United States)

Stevens, Jonathan R; George, Robert A; Fusillo, Steven; Stern, Theodore A; Wilens, Timothy E

2010-02-01

Children and adolescents are being treated increasingly for attention-deficit/hyperactivity disorder (ADHD) with a variety of stimulants in higher than Food and Drug Administration (FDA)-approved doses and in combination with other medications. We sought to determine methylphenidate (MPH) concentrations in children and adolescents treated with high-dose, extended-release osmotic release oral system (OROS) MPH plus concomitant medications, and to examine MPH concentrations with respect to the safety and tolerability of treatment. Plasma MPH concentrations were measured by liquid chromatography-mass spectrometry 4-5 hours after administration of medication in a sample of youths diagnosed with ADHD. These youths were treated naturalistically with higher than FDA-approved doses of OROS MPH in addition to their concomitant medications. Markers of safety and tolerability (e.g., measures of blood pressure and heart rate) were also examined. Among the 17 patients (with a mean age of 16.2 +/- 2 years and a mean number of concurrent medications of 2.23 +/- 0.94), the mean plasma MPH concentration was 28 +/- 9.1 ng/mL, despite a mean daily dose of OROS MPH of 169 +/- 5 mg (3.0 +/- 0.8 mg/kg per day). No patient had a plasma MPH level >or=50 ng/mL or clinical signs of stimulant toxicity. No correlation was found between plasma MPH concentrations and OROS MPH dose or changes in vital signs. High-dose OROS MPH, used in combination with other medications, was not associated with either unusually elevated plasma MPH concentrations or with clinically meaningful changes in vital signs. Study limitations include a single time-point sampling of MPH concentrations, a small sample size, and a lack of outcome measures to address treatment effectiveness.

28 CFR 65.52 - Civil rights.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Civil rights. 65.52 Section 65.52... Additional Requirements § 65.52 Civil rights. The Act provides that “no person in any state shall on the... funds under the Act are also subject to the provisions of title VI of the Civil Rights Act of 1964...

40 CFR 178.65 - Judicial review.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Judicial review. 178.65 Section 178.65... REQUESTS FOR HEARINGS Judicial Review § 178.65 Judicial review. An order issued under § 178.37 is final... of the order in the Federal Register. The failure to file a petition for judicial review within the...

40 CFR 65.105 - Leak repair.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Leak repair. 65.105 Section 65.105... FEDERAL AIR RULE Equipment Leaks § 65.105 Leak repair. (a) Leak repair schedule. The owner or operator shall repair each leak detected as soon as practical but not later than 15 calendar days after it is...

55Co level properties

International Nuclear Information System (INIS)

Lodin, G.; Nilsson, L.; Erlandsson, B.; Lyttkens, J.

1975-01-01

The decay pf low-lying levels in 55 Co has been studied by means of the 54 Fe(d,nγ) 55 Co reaction. Neutron energies were determined by time-of-flight techniques using a pulsed incident beam and a large liquid scintillator. Gamma rays in coincidence with neutrons were detected by a Ge(Li)spectrometer, Three levels at 4720.8+-0.6, 4747.1+-0.6 and 5172.4+-0.6 keV were strongly populated. The 4720 and 5172 keV levels have earlier been identified as the isobaric analogues of the 55 Fe ground state and first excited state. On the basis of a comparison of the present results with previous particle-transfer reaction studies it is suggested that the ground state analogue is split into the 4720 and 4747 keV levels. A study of excitation functions of 54 Fe(d,n)transitions at incident deuteron energies between 5.0 and 6.0 MeV show that the spectroscopic strengths obtained from (d,n) experiments in this mass region at these energies depend strongly on the incident energy. (Auth.)

Adverse pregnancy outcomes after exposure to methylphenidate or atomoxetine during pregnancy

Directory of Open Access Journals (Sweden)

Bro SP

2015-01-01

Full Text Available Søren Pauli Bro,1 Maiken Ina Siegismund Kjaersgaard,2 Erik Thorlund Parner,2 Merete Juul Sørensen,3 Jørn Olsen,4 Bodil Hammer Bech,4 Lars Henning Pedersen,4,5 Jakob Christensen,6,7 Mogens Vestergaard11Research Unit and Section for General Practice, Department of Public Health, 2Section for Biostatistics, Department of Public Health, Aarhus University, 3Regional Center for Child and Adolescent Psychiatry, Aarhus University Hospital, 4Section for Epidemiology, Department of Public Health, 5Department of Clinical Medicine – Obstetrics and Gynecology, Aarhus University, 6Department of Clinical Pharmacology, 7Department of Neurology, Aarhus University Hospital, Aarhus, DenmarkObjective: To determine if prenatal exposure to methylphenidate (MPH or atomoxetine (ATX increases the risk of adverse pregnancy outcomes in women with attention deficit/hyperactivity disorder (ADHD.Materials and methods: This was a population-based cohort study of all pregnancies in Denmark from 1997 to 2008. Information on use of ADHD medication, ADHD diagnosis, and pregnancy outcomes was obtained from nationwide registers.Results: We identified 989,932 pregnancies, in which 186 (0.02% women used MPH/ATX and 275 (0.03% women had been diagnosed with ADHD but who did not take MPH/ATX. Our reference pregnancies had no exposure to MPH/ATX and no ADHD diagnosis. Exposure to MPH/ATX was associated with an increased risk of spontaneous abortion (SA; ie, death of an embryo or fetus in the first 22 weeks of gestation (adjusted relative risk [aRR] 1.55, 95% confidence interval [CI] 1.03–2.36. The risk of SA was also increased in pregnancies where the mother had ADHD but did not use MPH/ATX (aRR 1.56, 95% CI 1.11–2.20. The aRR of Apgar scores <10 was increased among exposed women (aRR 2.06, 95% CI 1.11–3.82 but not among unexposed women with ADHD (aRR 0.99, 95% CI 0.48–2.05.Conclusion: MPH/ATX was associated with a higher risk of SA, but our study indicated that it may at

7 CFR 1900.55 - Adverse action procedures.

Science.gov (United States)

2010-01-01

... 7 Agriculture 12 2010-01-01 2010-01-01 false Adverse action procedures. 1900.55 Section 1900.55 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS... REGULATIONS GENERAL Adverse Decisions and Administrative Appeals § 1900.55 Adverse action procedures. (a) If...

10 CFR 430.55 - Evaluation of application.

Science.gov (United States)

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Evaluation of application. 430.55 Section 430.55 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY CONSERVATION PROGRAM FOR CONSUMER PRODUCTS Small Business Exemptions § 430.55 Evaluation of application. The Secretary shall grant an application for exemption...

Prototyping the HPDP Chip on STM 65 NM Process

Science.gov (United States)

Papadas, C.; Dramitinos, G.; Syed, M.; Helfers, T.; Dedes, G.; Schoellkopf, J.-P.; Dugoujon, L.

2011-08-01

Currently Astrium GmbH is involved in the of the High Performance Data Processor (HPDP) development programme for telecommunication applications under a DLR contract. The HPDP project targets the implementation of the commercially available reconfigurable array processor IP (XPP from the company PACT XPP Technologies) in a radiation hardened technology.In the current complementary development phase funded under the Greek Industry Incentive scheme, it is planned to prototype the HPDP chip in commercial STM 65 nm technology. In addition it is also planned to utilise the preliminary radiation hardened components of this library wherever possible.This abstract gives an overview of the HPDP chip architecture, the basic details of the STM 65 nm process and the design flow foreseen for the prototyping. The paper will discuss the development and integration issues involved in using the STM 65 nm process (also including the available preliminary radiation hardened components) for designs targeted to be used in space applications.

9 CFR 55.6 - Mortgage against animals.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Mortgage against animals. 55.6 Section 55.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... DISEASE Chronic Wasting Disease Indemnification Program § 55.6 Mortgage against animals. When cervids have...

46 CFR 151.50-55 - Sulfur (molten).

Science.gov (United States)

2010-10-01

... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-55 Sulfur (molten). (a.... Heat transfer media shall be steam, and alternate media will require specific approval of the... 46 Shipping 5 2010-10-01 2010-10-01 false Sulfur (molten). 151.50-55 Section 151.50-55 Shipping...

41 CFR 105-55.014 - Liquidation of collateral.

Science.gov (United States)

2010-07-01

... collateral. 105-55.014 Section 105-55.014 Public Contracts and Property Management Federal Property... Administration 55-COLLECTION OF CLAIMS OWED THE UNITED STATES § 105-55.014 Liquidation of collateral. (a) The General Services Administration (GSA) will liquidate security or collateral through the exercise of a...

Genetic analysis of 55 northern Vietnamese patients with Wilson ...

Indian Academy of Sciences (India)

We used Sanger sequencing to identify mutation hot spots in 55 northern Vietnamese with a clinical diagnosis of WD. Mutations were screened and detected by direct DNA sequencing. A total of 26 different ATP7B gene mutations were identified, including seven novel mutations (five nonsense and two missense mutations).

MEEK OR OPPRESSED? READING MATTHEW 5:5 IN CONTEXT

African Journals Online (AJOL)

According to the Gospel of Matthew 5:5, Jesus pronounces a blessing on “the meek” ...... of one's land to the poor (J.T. Pe'ah, I, 15 b, 39). .... including the Sermon on the Plain (Matt 5:3-7:27 and Luke 6:20-49). ... New York: Harper Collins.

24 CFR 55.20 - Decision making process.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Decision making process. 55.20 Section 55.20 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development FLOODPLAIN MANAGEMENT Procedures for Making Determinations on Floodplain Management § 55.20 Decision making process. The decision making...

Detection of GAD65 autoantibodies of type-1 diabetes using anti-GAD65-abs reagent produced from bovine brain tissue

Directory of Open Access Journals (Sweden)

Djoko W. Soeatmadji

2005-12-01

Full Text Available Clinically, type 1 diabetes may presents as type 2 diabetes which sometimes not easily differentiated. Perhaps only autoimmune markers of β-cells destruction could differentiate those two clinical conditions. Due to extremely high cost ( $ 150/test, examination of anti-glutamic acid decarboxylase-65 auto-antibodies (anti-GAD65Abs may not be routinely performed in most, if not all, clinical laboratories in Indonesia. Hence, the production of anti-GAD65 Abs reagent in Indonesia may reduce the cost and improve the quality of diabetes care in Indonesia. We produce reagent to detect anti-GAD65-Abs using bovine brain tissue as source of GAD enzyme in 3 steps. Step 1, isolation, purification of GAD65 from bovine brain tissue and used it as a primary antigen to stimulate the generation of anti-GAD65 antibodies in Wistar rat. Step 2, the purified GAD65 antibodies were than used as a secondary antibody to induce the production of anti-anti-GAD65-antibodies in Wistar rat and rabbit. Step 3. Labeling  anti-anti GAD65-antibodies with alkaline phoshpatase and peroxidase, and detecting anti-GAD65Abs previously detected using commercial kit. The anti-anti-GAD65- antibodies reagent produced in our laboratories  successfully identify anti-GAD65-Abs of type 1 diabetic patients previously detected  with commercial reagent. (Med J Indones 2005; 14: 197-203Keywords: GAD, type-1 Diabetes

Evaluation of clinical and sonographic features in 55 children with tularemia.

Science.gov (United States)

Oz, Fatma; Eksioglu, Ayse; Tanır, Gonul; Bayhan, Gulsum; Metin, Özge; Teke, Turkan Aydın

2014-08-01

The aim of this study was to determine the clinical characteristics and sonographic features of lymphadenopathy (LAP) and to evaluate the treatment modalities and treatment outcomes in children with tularemia. Demographic characteristics, ultrasonographic and physical examination findings, and treatment outcomes in 55 tularemia patients (24 male and 31 female) with a mean age of 10.8 ± 4.0 years were analyzed retrospectively. Lymph node necrosis was classified in three stages based on ultrasound findings-stage 1, cortical microabscesses; stage 2, cortical and medullar abscesses; stage 3, total necrosis of the lymph node. In total, 50 (90%) of the patients had oropharyngeal, four (8%) had glandular, and one (2%) had oculoglandular tularemia. The most common symptoms were sore throat (67%) and fever (64%). LAP was the most frequently (100%) observed sign. Abscess formation was noted in 36 (65%) patients, of which seven (19%) were sonographically classified as stage 1, 20 (55%) as stage 2, and nine (26%) as stage 3. There was a statistically significant correlation between delayed treatment and stage of abscess formation in lymph nodes (p0.05). In all, nine (16%) of the patients did not respond to medical treatment, and surgical intervention was required. Tularemia should be considered in the differential diagnosis of children presenting with unexplained fever, sore throat, and cervical LAP in endemic areas. Sonographic findings may be useful in the evaluation and staging of this infection.

Genetic analysis of 55 northern Vietnamese patients with Wilson ...

Indian Academy of Sciences (India)

2017-12-19

Dec 19, 2017 ... We used Sanger sequencing to identify mutation hot spots in 55 northern Vietnamese with a clinical diagnosis of WD. Mutations were screened and detected by direct DNA sequencing. A total of 26 different ATP7B gene mutations were identified, including seven novel mutations (five nonsense and two ...

Radiometric observations of atmospheric attenuation at 20.6 and 31.65 GHz: The Wave Propagation Laboratory data base

Science.gov (United States)

Jacobson, Mark D.; Snider, J. B.; Westwater, E. R.

1993-01-01

The National Oceanic and Atmospheric Administration (NOAA) Wave Propagation Laboratory (WPL) presently operates five dual-channel microwave radiometers, one triple-channel microwave radiometer, and one six-channel microwave radiometer. The dual-channel radiometers operate at frequencies of 20.6 or 23.87 GHz and 31.4 or 31.65 GHz. The triple-channel radiometer operates at 20.6, 31.65, and 90.0 GHz. The six-channel radiometer operates at frequencies of 20.6, 31.65, 52.85, 53.85, 55.45, and 58.8 GHz. Recent brightness temperature measurements and attenuation values from some of the above radiometers are presented. These radiometric measurements, taken in different locations throughout the world, have given WPL a diverse set of measurements under a variety of atmospheric conditions. We propose to do a more complete attenuation analysis on these measurements in the future. In addition, a new spinning reflector was installed recently for the dual-channel radiometer at the Platteville, Colorado site. This reflector will extend our measurement capabilities during precipating conditions. Locating the three-channel and portable dual-channel radiometers at or near Greeley, Colorado to support the Advanced Communications Technology Satellite (ACTS) program is discussed.

Interactive effects of methylphenidate and alcohol on discrimination, conditioned place preference and motor coordination in C57BL/6J mice.

Science.gov (United States)

Griffin, William C; McGovern, Robin W; Bell, Guinevere H; Randall, Patrick K; Middaugh, Lawrence D; Patrick, Kennerly S

2013-02-01

Prior research indicates methylphenidate (MPH) and alcohol (ethanol, EtOH) interact to significantly affect responses humans and mice. The present studies tested the hypothesis that MPH and EtOH interact to potentiate ethanol-related behaviors in mice. We used several behavioral tasks including: drug discrimination in MPH-trained and EtOH-trained mice, conditioned place preference (CPP), rota-rod and the parallel rod apparatus. We also used gas chromatographic methods to measure brain tissue levels of EtOH and the D- and L-isomers of MPH and the metabolite, ethylphenidate (EPH). In discrimination, EtOH (1 g/kg) produced a significant leftward shift in the MPH generalization curve (1-2 mg/kg) for MPH-trained mice, but no effects of MPH (0.625-1.25 mg/kg) on EtOH discrimination in EtOH-trained mice (0-2.5 g/kg) were observed. In CPP, the MPH (1.25 mg/kg) and EtOH (1.75 g/kg) combination significantly increased time on the drug paired side compared to vehicle (30.7 %), but this was similar to MPH (28.8 %) and EtOH (33.6 %). Footslip errors measured in a parallel rod apparatus indicated that the drug combination was very ataxic, with footslips increasing 29.5 % compared to EtOH. Finally, brain EtOH concentrations were not altered by 1.75 g/kg EtOH combined with 1.25 mg/kg MPH. However, EtOH significantly increased D-MPH and L-EPH without changing L-MPH brain concentrations. The enhanced behavioral effects when EtOH is combined with MPH are likely due to the selective increase in brain D-MPH concentrations. These studies are consistent with observations in humans of increased interoceptive awareness of the drug combination and provide new clinical perspectives regarding enhanced ataxic effects of this drug combination.

11 CFR 100.55 - Extension of credit.

Science.gov (United States)

2010-01-01

... substantially similar to extensions of credit to nonpolitical debtors that are of similar risk and size of... 11 Federal Elections 1 2010-01-01 2010-01-01 false Extension of credit. 100.55 Section 100.55... Contribution (2 U.S.C. 431(8)) § 100.55 Extension of credit. The extension of credit by any person is a...

Techniques for intrinsically labeling wheat with 65Zn

International Nuclear Information System (INIS)

Starks, T.L.; Johnson, P.E.

1985-01-01

Several techniques of intrinsically labeling wheat with 65 Zn were compared: stem injection of 65 Zn, stem injection of 65 Zn + ZnSO 4 , foliar application of 65 Zn, and the addition of 65 Zn to a hydroponic solution. Incorporation levels of 65 Zn into the grain were 62.6% stem injection, 45.2% stem-injected 65 Zn + ZnSO 4 , 57.5% foliar application, and 2.3% hydroponic solution. Four protein fractions were extracted from fat-free whole wheat flour. Distribution of 65 Zn into the protein fractions for all treatments, was 8.5-20.3% in albumins and globulins, 47.4-60.3% in glutenins, 1-2.6% in gliadins, and 9.8-28.3% in the remaining proteins. Separation of the fractions by gel chromatography showed that protein and Zn distributions were similar among the treatments and when compared to the controls. Zinc-65 distribution was similar to the natural Zn distribution. These data illustrate that stem-injected 65 Zn is incorporated in the same manner and ratios as Zn naturally utilized by wheat

Structure of the Haro 6-5 complex

International Nuclear Information System (INIS)

Gledhill, T.M.; Warren-Smith, R.F.; Scarrott, S.M.

1986-01-01

An imaging polarization study of the Haro 6-5 complex including its emission-line jet feature is presented. The sources of illumination are identified and a geometrical interpretation for the system is suggested. In the R waveband the emission-line jet is linearly polarized at a level of 18 +- 2 per cent at PA 147 +- 8 0 , implying that it is a reflection phenomenon. The implications of this observation are discussed. (author)

Measurements of (n,xp), (n,xd) double differential cross sections of Al and C for neutrons at 75 and 65 MeV

Energy Technology Data Exchange (ETDEWEB)

Nauchi, Yasushi; Baba, Mamoru; Iwasaki, Tomohiko [Tohoku Univ., Sendai (Japan). Faculty of Engineering] [and others

1998-03-01

The (n,xp) and (n,xd) double differential cross sections (DDXs) of Al and C were measured at 6 angles (12deg, 17deg, 25deg, 40deg, 55deg and 70deg) for neutrons En=65 and 75 MeV. These data are compared with theoretical calculations of ISOBAR and GNASH. A new wide range spectrometer under fabrication to down the detection threshold is also described. (author)

An exploratory study of the combined effects of orally administered methylphenidate and delta-9-tetrahydrocannabinol (THC) on cardiovascular function, subjective effects, and performance in healthy adults.

Science.gov (United States)

Kollins, Scott H; Schoenfelder, Erin N; English, Joseph S; Holdaway, Alex; Van Voorhees, Elizabeth; O'Brien, Benjamin R; Dew, Rachel; Chrisman, Allan K

2015-01-01

Methylphenidate (MPH) is commonly prescribed for the treatment of Attention Deficit Hyperactivity Disorder (ADHD), and is often used illicitly by young adults. Illicit users often coadminister MPH with marijuana. Little is known about physiologic and subjective effects of these substances used in combination. In this double-blind, cross-over experiment, sixteen healthy adult subjects free from psychiatric illness (including ADHD) and reporting modest levels of marijuana use participated in 6 experimental sessions wherein all combinations of placebo or 10mg oral doses of delta-9-tetrahydocannibinol (THC); and 0mg, 10mg and 40 mg of MPH were administered. Sessions were separated by at least 48 hours. Vital signs, subjective effects, and performance measure were collected. THC and MPH showed additive effects on heart rate and rate pressure product (e.g., peak heart rate for 10mg THC+0mg, 10mg, and 40 mg MPH=89.1, 95.9, 102.0 beats/min, respectively). Main effects of THC and MPH were also observed on a range of subjective measures of drug effects, and significant THC dose × MPH dose interactions were found on measures of "Feel Drug," "Good Effects," and "Take Drug Again." THC increased commission errors on a continuous performance test (CPT) and MPH reduced reaction time variability on this measure. Effects of THC, MPH, and their combination were variable on a measure of working memory (n-back task), though in general, MPH decreased reaction times and THC mitigated these effects. These results suggest that the combination of low to moderate doses of MPH and THC produces unique effects on cardiovascular function, subjective effects and performance measures. Copyright © 2014 Elsevier Inc. All rights reserved.

Venera-15: water vapor at altitudes of 55 - 65 km.

Science.gov (United States)

Zasova, L. V.; Ignat'ev, N. I.; Moroz, V. I.; Khatuntsev, I. V.

1999-02-01

Spectra of Venus outgoing thermal radiation were measured in 1983 onboard the Venera-15 spacecraft (Venus' artificial satellite) in the 6 - 40 μm range at different latitudes and longitudes. Results of a new analysis of these spectra are presented, which have been elaborated in order to revise the water vapor content estimates.

14 CFR 65.19 - Retesting after failure.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Retesting after failure. 65.19 Section 65.19 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: AIRMEN OTHER THAN FLIGHT CREWMEMBERS General § 65.19 Retesting after failure. An...

49 CFR 1242.77 - Administration (account XX-55-01).

Science.gov (United States)

2010-10-01

... 49 Transportation 9 2010-10-01 2010-10-01 false Administration (account XX-55-01). 1242.77 Section...-Transportation § 1242.77 Administration (account XX-55-01). Separate common expenses in the same proportion as... systems operations and loss and damage claims processing (accounts XX-55-76, XX-55-77 and XX-55-78). ...

Does Methylphenidate Affect Cystometric Parameters in Spontaneously Hypertensive Rats?

Directory of Open Access Journals (Sweden)

Khae Hawn Kim

2015-06-01

Full Text Available Purpose: Methylphenidate (MPH is one of the most commonly prescribed psychostimulants for attention deficit hyperactivity disorder (ADHD. However, there is limited research on its effects on lower urinary tract function. This study investigated changes in cystometric parameters after intragastric administration of MPH in conscious spontaneously hypertensive rats (SHRs, an animal model of ADHD. Methods: Fourteen- to 16-week-old male SHRs (n=10, weighing between 280 and 315 g, were used. Three micturition cycles were recorded before administering MPH. One hour after each intragastric MPH injection, three cycles of cystometrogram were obtained in the awake condition. Various cystometric parameters were evaluated, including basal pressure (BP, maximal pressure (MP, threshold pressure (TP, bladder capacity (BC, micturition volume (MV, micturition interval (MI, and residual volume (RV. The data were analyzed using paired Student t-tests. Results: Five SHRs were each administered a dose of 3-mg/kg MPH, and the other five received a dose of 6-mg/kg MPH. BP and MP increased significantly in the rats that received the 3-mg/kg MPH injection, but not in those that received the 6-mg/kg injection. BC, MV, and MI significantly increased in the rats that received the 6-mg/kg MPH injection, but not in those that received the 3-mg/kg injection. There were no significant changes in TP after either injection. Conclusions: Significant increases in BC, MV, and MI after the 6-mg/kg MPH injection suggest that the peripheral and the central nervous systems may play important roles in bladder function in those receiving MPH for ADHD.

7 CFR 766.55 - Eligibility determination.

Science.gov (United States)

2010-01-01

... 7 Agriculture 7 2010-01-01 2010-01-01 false Eligibility determination. 766.55 Section 766.55 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF... determination. Within 30 days of a complete DSA application, the Agency will determine if the borrower meets the...

2 CFR 225.55 - Information contact.

Science.gov (United States)

2010-01-01

... information concerning this part may be obtained by contacting the Office of Federal Financial Management, Financial Standards and Reporting Branch, Office of Management and Budget, Washington, DC 20503, telephone... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Information contact. 225.55 Section 225.55...

27 CFR 6.55 - Display service.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Display service. 6.55 Section 6.55 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Unlawful Inducements Paying for Advertising, Display Or...

Division XII: Commission 55: Communicating Astronomy with the Public

Science.gov (United States)

Christensen, Lars Lindberg; Russo, Pedro; Robson, Ian; Arcand, Kimberly Kowal; Fienberg, Richard Tresch; Ödman-Govender, Carolina; Sekiguchi, Kazuhiro; Wheeler, Pete; Zhu, Jin

2015-08-01

A good fraction of the Commission 55 (C55) Organizing Committee met in Beijing in August at the XXVIII IAU General Assembly, where C55 organized Special Session 14 (SpS14) entitled ``Communicating Astronomy with the Public for Scientists.'' During our C55 business meeting, and again during an impromptu gathering a few days later, we discussed changes in the IAU's organizational and programmatic structure and how these changes might affect C55. This report summarizes key points and offers some ideas about what we're calling ``C55 v2.0.'' For background and reference, see the C55 website at http://www.communicatingastronomy.org.

49 CFR 229.55 - Piston travel.

Science.gov (United States)

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Piston travel. 229.55 Section 229.55... Piston travel. (a) Brake cylinder piston travel shall be sufficient to provide brake shoe clearance when... piston travel may not exceed 11/2 inches less than the total possible piston travel. The total possible...

7 CFR 65.140 - Food service establishment.

Science.gov (United States)

2010-01-01

... retail establishments that provide ready-to-eat foods that are consumed either on or outside of the... 7 Agriculture 3 2010-01-01 2010-01-01 false Food service establishment. 65.140 Section 65.140..., PEANUTS, AND GINSENG General Provisions Definitions § 65.140 Food service establishment. Food service...

24 CFR 234.65 - Nature of title.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Nature of title. 234.65 Section 234.65 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... OWNERSHIP MORTGAGE INSURANCE Eligibility Requirements-Individually Owned Units § 234.65 Nature of title. A...

7 CFR 29.65 - Accessibility of tobacco.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Accessibility of tobacco. 29.65 Section 29.65... REGULATIONS TOBACCO INSPECTION Regulations Permissive Inspection § 29.65 Accessibility of tobacco. All tobacco... characteristics or for drawing of samples. In the case of tobacco in packages, the coverings shall be removed by...

42 CFR 409.65 - Lifetime reserve days.

Science.gov (United States)

2010-10-01

... HOSPITAL INSURANCE BENEFITS Scope of Hospital Insurance Benefits § 409.65 Lifetime reserve days. (a... private insurance coverage that begins after the first 90 inpatient days in a benefit period, or if the... 42 Public Health 2 2010-10-01 2010-10-01 false Lifetime reserve days. 409.65 Section 409.65 Public...

46 CFR 98.25-65 - Filling density.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Filling density. 98.25-65 Section 98.25-65 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL... § 98.25-65 Filling density. (a) The filling density, or the percent ratio of the liquefied gas that may...

Obtaining a citric tristeza virus p65 protein antibody and preliminary results of p65 in vivo expression

Directory of Open Access Journals (Sweden)

Yanneth Torres

2003-07-01

Full Text Available The citric tristeza virus (CTV belongs to the Closteroviridae family which indudes the only vegetal viruses possessing genes homologous to HSP70 thermal cellular shock proteins in their genome. Such is the case of the gene encoding for the CTV p65 protein which presents high homology with the HSP70 protein family. It has been shown recently that HSP70h viral proteins (such as CTV p65 are involved both in viral assembly, as a microtubule binding protein, and in cell-cell movement. Since CTV is the most deleterious citrus pathogen, understanding this protein's role in the pathogenesis process is important. Rabbits were immunised with four synthetic peptides (corresponding to CTV p65 thermal shock protein's carboxyl-terminal region to obtain polyclonal antibodies. All the peptides used were immunogenic, even though two of them showed greater response. Whilst none of the antibodies obtained reacted to non-infected plant extract, the p65 proteins was detected in extracts taken from citric plants infected with CTV Based on the antibody's reaction to two Colombian isolates having different serological characteristics, the p65 antibody's immunological behaviour appeared to be independent of the symptomatic severity of the CTV isolates. It was shown that the ORF encoded for the HSP70 homologue in CTV was expressed in vivo, even though the p65 antibody was only detected in concentrated protein extracts taken from infected plants, supporting reports from other studies that the concentration of this protein in plants infected with CTV is low. This is the first time that a polyclonal CTV antibody has been obtained in Colombia against p65 (a protein intervening in viral assembly and movement. Adapting a technique for obtaining p65 antibodies by using synthetic peptides as immunogens could be useful in the future for detecting or diagnosing p65 proteins present in different Colombian CTV isolates, especially in developing studies contributing towards greater

High spin rotational bands in 65 Zn

Indian Academy of Sciences (India)

The nucleus 30 65 Zn was studied using the 52Cr(16O, 2)65Zn reaction at a beam energy of 65 MeV. The level scheme is extended up to an excitation energy of 10.57 MeV for spin-parity (41/2ħ) with several newly observed transitions placed in it.

13 CFR 115.65 - General PSB procedures.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false General PSB procedures. 115.65 Section 115.65 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SURETY BOND GUARANTEE Preferred Surety Bond (PSB) Guarantees § 115.65 General PSB procedures. (a) Retention of information. A PSB Surety must comply with all applicable SBA...

Verification and Validation of RADTRAN 5.5.

Energy Technology Data Exchange (ETDEWEB)

Osborn, Douglas.; Weiner, Ruth F.; Mills, George Scott; Hamp, Steve C.

2005-02-01

This document contains a description of the verification and validation process used for the RADTRAN 5.5 code. The verification and validation process ensured the proper calculational models and mathematical and numerical methods were used in the RADTRAN 5.5 code for the determination of risk and consequence assessments. The differences between RADTRAN 5 and RADTRAN 5.5 are the addition of tables, an expanded isotope library, and the additional User-Defined meteorological option for accident dispersion. 3

15 CFR 5.5 - Vending machines.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Vending machines. 5.5 Section 5.5... machines. (a) The income from any vending machines which are located within reasonable proximity to and are... shall be assigned to the operator of such stand. (b) If a vending machine vends articles of a type...

40 CFR 205.55-5 - Labeling-exterior. [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Labeling-exterior. [Reserved] 205.55-5 Section 205.55-5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.55-5 Labeling...

An investigation of drag reduction for tractor trailer vehicles with air deflector and boattail. [wind tunnel tests

Science.gov (United States)

Muirhead, V. U.

1981-01-01

A wind tunnel investigation was conducted to determine the influence of several physical variables on the aerodynamic drag of a trailer model. The physical variables included: a cab mounted wind deflector, boattail on trailer, flow vanes on trailer front, forced transition on trailer, and decreased gap between tractor and trailer. Tests were conducted at yaw angles (relative wind angles) of 0, 5, 10, 20, and 30 degrees and Reynolds numbers of 3.58 x 10 to the 5th power 6.12 x 10 to the 5th power based upon the equivalent diameter of the vehicles. The wind deflector on top of the cab produced a calculated reduction in fuel consumption of about 5 percent of the aerodynamic portion of the fuel budget for a wind speed of 15.3 km/hr (9.5 mph) over a wind angle range of 0 deg to 180 deg and for a vehicle speed of 88.5 km/hr (55 mph). The boattail produced a calculated 7 percent to 8 percent reduction in fuel consumption under the same conditions. The decrease in gap reduced the calculated fuel consumption by about 5 percent of the aerodynamic portion of the fuel budget.

7 CFR 929.65 - Confidential information.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 929.65 Section 929.65 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... position, financial condition, or business operations of the particular handler from whom received, shall...

19 CFR 210.55 - Content of service copies.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Content of service copies. 210.55 Section 210.55 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Temporary Relief § 210.55 Content of service copies. (a) Any...

[AIMS65 score validation for upper gastrointestinal bleeding in the National Hospital Cayetano Heredia].

Science.gov (United States)

Aguilar Sánchez, Víctor; Bravo Paredes, Eduar Alban; Pinto Valdivia, José Luis; Valenzuela Granados, Vanessa; Espinoza-Rios, Jorge Luis

2015-01-01

To validate the score AIMS65 in patients with upper gastrointestinal bleeding, in terms of mortality and rebleeding a 30-day event. Patients included were those with higher age to 18 years attending the Hospital Nacional Cayetano Heredia during the period May 2013 to December 2014, by upper gastrointestinal bleeding. Data were analyzed using ROC curve (Receiver Operating Characteristic) and the area was obtained under the curve (AUC) to properly qualify the score AIMS65. 209 patients were included, 66.03% were male, with an average age of 58.02 years. The mortality rate was 7.65%, the multiorgan failure the most common cause of death. Plus 3.82% of the patients had recurrent bleeding and 11% required a transfusion of more than 2 units of blood. When analyzing the ROC curve with AIMS65 and mortality score a value of 0.9122 is reported; identifying it as cutoff greater than or equal to 3 value in the score AIMS65 to discriminate patients at high risk of death, likewise the ROC curve was analyzed for recurrence of bleeding with a value of 0.6266 and the need to Transfusion of packed red blood cells over two a value of 0.7421. And it was determined the average hospital stay with a value of 4.8 days, however, no correlation was found with the score AIMS65. AIMS65 score is a good predictor of mortality, and is useful for predicting the need for transfusion of more than 2 globular packages. However it is not a good predictor for recurrence of bleeding, or hospital stay.

Preparing Master of Public Health Graduates to Work in Local Health Departments.

Science.gov (United States)

Hemans-Henry, Calaine; Blake, Janice; Parton, Hilary; Koppaka, Ram; Greene, Carolyn M

2016-01-01

To identify key competencies and skills that all master of public health (MPH) graduates should have to be prepared to work in a local health department. In 2011-2012, the New York City Department of Health and Mental Hygiene administered electronic surveys to 2 categories of staff: current staff with an MPH as their highest degree, and current hiring managers. In all, 312 (77%) staff members with an MPH as their highest degree and 170 (57%) hiring managers responded to the survey. Of the respondents with an MPH as their highest degree, 85% stated that their MPH program prepared them for work at the New York City Health Department. Skills for which MPH graduates most often stated they were underprepared included facility in using SAS® statistical software, quantitative data analysis/statistics, personnel management/leadership, and data collection/database management/data cleaning. Among the skills hiring managers identified as required of MPH graduates, the following were most often cited as those for which newly hired MPH graduates were inadequately prepared: quantitative data analysis, researching/conducting literature reviews, scientific writing and publication, management skills, and working with contracts/requests for proposals. These findings suggest that MPH graduates could be better prepared to work in a local health department upon graduation. To be successful, new MPH graduate hires should possess fundamental skills and knowledge related to analysis, communication, management, and leadership. Local health departments and schools of public health must each contribute to the development of the current and future public health workforce through both formal learning opportunities and supplementary employment-based training to reinforce prior coursework and facilitate practical skill development.

4 CFR 5.5 - Travel, transportation, and subsistence.

Science.gov (United States)

2010-01-01

... 4 Accounts 1 2010-01-01 2010-01-01 false Travel, transportation, and subsistence. 5.5 Section 5.5 Accounts GOVERNMENT ACCOUNTABILITY OFFICE PERSONNEL SYSTEM COMPENSATION § 5.5 Travel, transportation, and subsistence. The provisions of chapter 57 of title 5, U.S. Code and the implementing regulations for the...

29 CFR 1915.55 - Gas welding and cutting.

Science.gov (United States)

2010-07-01

... 29 Labor 7 2010-07-01 2010-07-01 false Gas welding and cutting. 1915.55 Section 1915.55 Labor... (CONTINUED) OCCUPATIONAL SAFETY AND HEALTH STANDARDS FOR SHIPYARD EMPLOYMENT Welding, Cutting and Heating § 1915.55 Gas welding and cutting. The provisions of this section shall apply to ship repairing...

42 CFR 65.4 - Project requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Project requirements. 65.4 Section 65.4 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING... appropriate academic disciplines and talents. Joint applications must describe the cooperative arrangements...

30 CFR 7.65 - Critical characteristics.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Critical characteristics. 7.65 Section 7.65 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND... Critical characteristics. The following critical characteristics shall be inspected or tested on each...

Osmotic Release Oral System Methylphenidate Versus Atomoxetine for the Treatment of Attention-Deficit/Hyperactivity Disorder in Chinese Youth: 8-Week Comparative Efficacy and 1-Year Follow-Up.

Science.gov (United States)

Su, Yi; Yang, Li; Stein, Mark A; Cao, Qingjiu; Wang, Yufeng

2016-05-01

The purpose of this study was to compare the short-term efficacy, tolerability, and 1-year adherence in Chinese children and adolescents with attention-deficit/hyperactivity disorder (ADHD) treated with either osmotic release oral system methylphenidate (OROS MPH) or atomoxetine (ATX). Children and adolescents meeting Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV) criteria for ADHD were randomly assigned to receive either OROS MPH (n = 119) or ATX (n = 118). Participants underwent a 1-4 week dose titration period to determine optimal dose, and then were maintained on that dose for 4 weeks (maintenance period). Assessment for efficacy was conducted every week over the titration period and at the end of the maintenance period. The primary efficacy measure was the investigator-rated total ADHD Rating Scale-IV (ADHD-RS-IV) score. Response was further classified as remission (ADHD-RS-IV [18 or 9 items] average score ≤1), robust improvement (ADHD-RS-IV ≥40% decrease in total score), or improvement (≥ 25% decrease in total score) at the end of maintenance period. Medication adherence (taking medication at least 5 days in 1 week) and reasons for nonadherence were evaluated every week over the titration period, at the end of maintenance period, and then at 3, 6, and 12 months. At the end of maintenance period, both OROS MPH and ATX were associated with significant and similar reductions from baseline in ADHD symptoms. Percentages achieving remission, robust improvement, and improvement were comparable for OROS MPH and ATX treatment (35.3% vs. 37.1%, 45.4% vs. 44.8%, 65.5% vs. 66.4%). Medication use decreased over time for both treatments; however, at end of maintenance period, 3 month, 6 month, and 1 year follow-ups, subjects in the OROS MPH group were more likely to be compliant with treatment (74.8%, 50.4%, 38.7%, and 21.8% for OROS MPH vs. 52.5%, 33.9%, 12.7%, and 3.4% for ATX) ( p < 0.05). The most common reasons for

46 CFR 35.01-55 - Pilot boarding operation.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Pilot boarding operation. 35.01-55 Section 35.01-55... Requirements § 35.01-55 Pilot boarding operation. (a) The master shall ensure that pilot boarding equipment is... instructions. (b) The master shall ensure compliance with the following during pilot boarding operations: (1...

25 CFR 141.55 - Price monitoring and control.

Science.gov (United States)

2010-04-01

... be made a survey of the prices of flour, sugar, fresh eggs, lard, coffee, ground beef, bread, cheese... 25 Indians 1 2010-04-01 2010-04-01 false Price monitoring and control. 141.55 Section 141.55... THE NAVAJO, HOPI AND ZUNI RESERVATIONS Enforcement Powers, Procedures and Remedies § 141.55 Price...

ALMA Reveals Molecular Cloud N55 in the Large Magellanic Cloud as a Site of Massive Star Formation

Science.gov (United States)

Naslim, N.; Tokuda, K.; Onishi, T.; Kemper, F.; Wong, T.; Morata, O.; Takada, S.; Harada, R.; Kawamura, A.; Saigo, K.; Indebetouw, R.; Madden, S. C.; Hony, S.; Meixner, M.

2018-02-01

We present the molecular cloud properties of N55 in the Large Magellanic Cloud using 12CO(1–0) and 13CO(1–0) observations obtained with Atacama Large Millimeter Array. We have done a detailed study of molecular gas properties, to understand how the cloud properties of N55 differ from Galactic clouds. Most CO emission appears clumpy in N55, and molecular cores that have young stellar objects (YSOs) show larger linewidths and masses. The massive clumps are associated with high and intermediate mass YSOs. The clump masses are determined by local thermodynamic equilibrium and virial analysis of the 12CO and 13CO emissions. These mass estimates lead to the conclusion that (a) the clumps are in self-gravitational virial equilibrium, and (b) the 12CO(1–0)-to-H2 conversion factor, {X}{CO}, is 6.5 × 1020 cm‑2 (K km s‑1)‑1. This CO-to-H2 conversion factor for N55 clumps is measured at a spatial scale of ∼0.67 pc, which is about two times higher than the {X}{CO} value of the Orion cloud at a similar spatial scale. The core mass function of N55 clearly show a turnover below 200 {M}ȯ , separating the low-mass end from the high-mass end. The low-mass end of the 12CO mass spectrum is fitted with a power law of index 0.5 ± 0.1, while for 13CO it is fitted with a power law index 0.6 ± 0.2. In the high-mass end, the core mass spectrum is fitted with a power index of 2.0 ± 0.3 for 12CO, and with 2.5 ± 0.4 for 13CO. This power law behavior of the core mass function in N55 is consistent with many Galactic clouds.

Nebraska wind resource assessment first year results

Energy Technology Data Exchange (ETDEWEB)

Hurley, P.J.F.; Vilhauer, R. [RLA Consulting, Inc., Bothell, WA (United States); Stooksbury, D. [Univ. of Nebraska, Lincoln, NE (United States)

1996-12-31

This paper presents the preliminary results from a wind resource assessment program in Nebraska sponsored by the Nebraska Power Association. During the first year the measured annual wind speed at 40 meters ranged from 6.5 - 7.5 m/s (14.6 - 16.8 mph) at eight stations across the state. The site selection process is discussed as well as an overview of the site characteristics at the monitoring locations. Results from the first year monitoring period including data recovery rate, directionality, average wind speeds, wind shear, and turbulence intensity are presented. Results from the eight sites are qualitatively compared with other midwest and west coast locations. 5 figs., 2 tabs.

10 CFR 50.65 - Requirements for monitoring the effectiveness of maintenance at nuclear power plants.

Science.gov (United States)

2010-01-01

... maintenance at nuclear power plants. 50.65 Section 50.65 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC..., including normal shutdown operations. (a)(1) Each holder of an operating license for a nuclear power plant... corrective action shall be taken. For a nuclear power plant for which the licensee has submitted the...

7 CFR 983.65 - Confidential information.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 983.65 Section 983.65 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... the particular handler or their customers shall be received by, and at all times kept in the custody...

34 CFR 106.55 - Job classification and structure.

Science.gov (United States)

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Job classification and structure. 106.55 Section 106.55 Education Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF... Prohibited § 106.55 Job classification and structure. A recipient shall not: (a) Classify a job as being for...

Phasons modulate the atomic Debye-Waller factors in incommensurate structures: Experimental evidence in ThBr4 at 55 K

International Nuclear Information System (INIS)

Madariaga, G.; Perez-Mato, J.M.; Aramburu, I.

1993-01-01

The incommensurate displacive structure of β-ThBr 4 at 55 K has been determined from a neutron diffraction data set including main reflections and first-order satellites. The superspace group is Psub(s anti 1 s1)sup(I4 1 /amd). Final agreement factors are 0.0193, 0.0186 and 0.045 for all, main and satellite reflections, respectively. It is shown that the effect of phasons on the atomic Debye-Waller factors can be quantified by two additional structural parameters: The modulus β 11,2 Br and the phase χ 11,2 Br of a second harmonic that spatially modulates the temperature factors of Br atoms. Results are in good agreement, within the resolution of the experimental data, with the theoretically expected value for χ 11,2 Br . Crystal data for the average structure: M r =551.65, tetragonal, I4 1 /amd, a=8.919(1), c=7.902(1) A, V=628.6(2) A 3 , Z=4, D x =5.82 Mg m -3 , λ=0.84 A, wavevector q=0.32c*. (orig.)

Aboriginal and Torres Strait Islander public health: online and integrated into core Master of Public Health subjects

Directory of Open Access Journals (Sweden)

Lynnell Angus

2016-04-01

Full Text Available The Master of Public Health (MPH is an internationally recognised post-graduate qualification for building the public health workforce. In Australia, MPH graduate attributes include six Indigenous public health (IPH competencies. The University of Melbourne MPH program includes five core subjects and ten specialisation streams, of which one is Indigenous health. Unless students complete this specialisation or electives in Indigenous health, it is possible for students to graduate without attaining the IPH competencies. To address this issue in a crowded and competitive curriculum an innovative approach to integrating the IPH competencies in core MPH subjects was developed. Five online modules that corresponded with the learning outcomes of the core public health subjects were developed, implemented and evaluated in 2015. This brief report outlines the conceptualisation, development, and description of the curriculum content; it also provides preliminary student evaluation and staff feedback on the integration project.

21 CFR 211.65 - Equipment construction.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Equipment construction. 211.65 Section 211.65 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS... construction. (a) Equipment shall be constructed so that surfaces that contact components, in-process materials...

46 CFR 4.03-55 - Law enforcement officer.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Law enforcement officer. 4.03-55 Section 4.03-55 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC MARINE CASUALTIES AND INVESTIGATIONS Definitions § 4.03-55 Law enforcement officer. Law enforcement officer means a Coast Guard commissioned, warrant or petty officer...

Improved SCR ac Motor Controller for Battery Powered Urban Electric Vehicles

Science.gov (United States)

Latos, T. S.

1982-01-01

An improved ac motor controller, which when coupled to a standard ac induction motor and a dc propulsion battery would provide a complete electric vehicle power train with the exception of the mechanical transmission and drive wheels was designed. In such a system, the motor controller converts the dc electrical power available at the battery terminals to ac electrical power for the induction motor in response to the drivers commands. The performance requirements of a hypothetical electric vehicle with an upper weight bound of 1590 kg (3500 lb) were used to determine the power rating of the controller. Vehicle acceleration capability, top speed, and gradeability requisites were contained in the Society of Automotive Engineers (SAE) Schedule 227a(d) driving cycle. The important capabilities contained in this driving cycle are a vehicle acceleration requirement of 0 to 72.4 kmph (0 to 45 mph) in 28 seconds a top speed of 88.5 kmph (55 mph), and the ability to negotiate a 10% grade at 48 kmph (30 mph). A 10% grade is defined as one foot of vertical rise per 10 feet of horizontal distance.

40 CFR 273.55 - Off-site shipments.

Science.gov (United States)

2010-07-01

....55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR UNIVERSAL WASTE MANAGEMENT Standards for Universal Waste Transporters § 273.55 Off-site... universal waste being shipped off-site meets the Department of Transportation's definition of hazardous...

A Comprehensive Analysis of the X-15 Flight 3-65 Accident

Science.gov (United States)

Dennehy, Cornelius J.; Orr, Jeb S.; Barshi, Immanuel; Statler, Irving C.

2014-01-01

The November 15, 1967, loss of X-15 Flight 3-65-97 (hereafter referred to as Flight 3-65) was a unique incident in that it was the first and only aerospace flight accident involving loss of crew on a vehicle with an adaptive flight control system (AFCS). In addition, Flight 3-65 remains the only incidence of a single-pilot departure from controlled flight of a manned entry vehicle in a hypersonic flight regime. To mitigate risk to emerging aerospace systems, the NASA Engineering and Safety Center (NESC) proposed a comprehensive review of this accident. The goal of the assessment was to resolve lingering questions regarding the failure modes of the aircraft systems (including the AFCS) and thoroughly analyze the interactions among the human agents and autonomous systems that contributed to the loss of the pilot and aircraft. This document contains the outcome of the accident review.

Methylphenidate-induced improvements of various measures of attention in adults with attention deficit hyperactivity disorder.

Science.gov (United States)

Tucha, O; Mecklinger, L; Laufkötter, R; Klein, H E; Walitza, S; Lange, K W

2006-10-01

The present study examined the effect of the stimulant medication methylphenidate (MPH) on attentional functioning of adults with ADHD. Sixteen adults with a diagnosed ADHD without comorbidity were assessed twice, at baseline off MPH and following MPH treatment. The assessment battery consisted of reaction time tasks of low complexity, including measures of alertness--subdivided into tonic and phasic alertness, vigilance, divided attention, flexibility and such aspects of selective attention as including focused attention, inhibition and integration of sensory information. In addition, 16 healthy participants who were matched to adults with ADHD according to sex, age, education level and intellectual functions were also assessed twice using the same test battery. The results of the present study suggest that adults with ADHD off stimulant medication are seriously impaired in various components of attention including vigilance, divided attention, selective attention and flexibility. These impairments of attention were observed primarily in regard to reaction time and its variability. Treatment of adults with ADHD using individually tailored doses of MPH has a positive effect on measures of alertness, vigilance, selective attention, divided attention and flexibility. However, even on MPH adults with ADHD displayed considerable deficits in vigilance and integration of sensory information. The present findings indicate that adults with ADHD are not differentially impaired in attentional processes but may suffer from a more global deficit of attention. Although MPH treatment has been found to be effective in the treatment of the attention deficit of adults with ADHD, additional treatment appears to be necessary.

Assessment of CD4+ T cell responses to glutamic acid decarboxylase 65 using DQ8 tetramers reveals a pathogenic role of GAD65 121-140 and GAD65 250-266 in T1D development.

Directory of Open Access Journals (Sweden)

I-Ting Chow

Full Text Available Susceptibility to type 1 diabetes (T1D is strongly associated with MHC class II molecules, particularly HLA-DQ8 (DQ8: DQA1*03:01/DQB1*03:02. Monitoring T1D-specific T cell responses to DQ8-restricted epitopes may be key to understanding the immunopathology of the disease. In this study, we examined DQ8-restricted T cell responses to glutamic acid decarboxylase 65 (GAD65 using DQ8 tetramers. We demonstrated that GAD65 121-140 and GAD65 250-266 elicited responses from DQ8+ subjects. Circulating CD4+ T cells specific for these epitopes were detected significantly more often in T1D patients than in healthy individuals after in vitro expansion. T cell clones specific for GAD65 121-140 and GAD65 250-266 carried a Th1-dominant phenotype, with some of the GAD65 121-140-specific T cell clones producing IL-17. GAD65 250-266-specific CD4+ T cells could also be detected by direct ex vivo staining. Analysis of unmanipulated peripheral blood mononuclear cells (PBMCs revealed that GAD65 250-266-specific T cells could be found in both healthy and diabetic individuals but the frequencies of specific T cells were higher in subjects with type 1 diabetes. Taken together, our results suggest a proinflammatory role for T cells specific for DQ8-restricted GAD65 121-140 and GAD65 250-266 epitopes and implicate their possible contribution to the progression of T1D.

46 CFR 42.05-65 - Surveyor.

Science.gov (United States)

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Surveyor. 42.05-65 Section 42.05-65 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES DOMESTIC AND FOREIGN VOYAGES BY SEA Definition of... American Bureau of Shipping or other classification society recognized by the Commandant as the person who...

14 CFR 31.65 - Position lights.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Position lights. 31.65 Section 31.65 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS...; and z is not greater than 0.002. (2) Aviation white— x is not less than 0.300 and not greater than 0...

7 CFR 1216.55 - Investment of funds.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Investment of funds. 1216.55 Section 1216.55 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... financial institutions that are members of the Federal Reserve system; or obligations that are fully...

Water Use Efficiency of Cotton and Wheat Crops at Various Management Allowed Depletion in Lower Indus Basin

Directory of Open Access Journals (Sweden)

KHALIFA QASIML AGHARI

2010-10-01

Full Text Available This paper deals with contemporary irrigation water management of major crops in Lower Indus Basin of Pakistan. Field experiments were conducted to estimate the optimum WUE (Water Use Efficiency for various MAD (Management Allowed Depletion levels including 55, 65 and 75% for cotton crop, and 45, 55 and 65% for wheat crop. The daily actual crop Etca (Evapotranspiration was observed through gypsum blocks and a drainage Lysimeter. The observed seasonal cotton crops ETca in the experiments were 486, 413, and 397 mm for 55, 65, and 75% MAD levels, respectively. Similarly, wheat crops ETca observed were 363, 359, and 332mm for 45, 55, and 65% MAD levels, respectively. The WUE determined in terms of seed-cotton yield per unit of seasonal water use were 6.0, 6.5, and 5.8kg (ha mm-1 The corresponding values of WUE for wheat were 14.1, 15.0 and 13.4kg (ha mm-1. Hence; the highest WUE was achieved with MAD at 65% for cotton and at 55% for wheat.

CLUB 55

Directory of Open Access Journals (Sweden)

Ramón Rojano

2000-01-01

Full Text Available Este artículo presenta una reconceptualización del concepto de envejecimento. Se plantea la necesidad de revisar las etapas del desarrollo psicológico descritas por Erikson. Los recientes cambios demográficos y la prolongación de la expectativa de vida justifican el replanteamiento conceptual. Actualmente la tercera edad no es la última edad. Características que se le atribuían a este período de la vida ahora corresponden a la cuarta edad. El Departamento de Servicios Humanos de Hartford ha creado el Club 55, un proyecto basado en este nuevo paradigma.

Geophysical drillhole logging and imaging of drillholes OL-KR54, OL-KR55 and OL-KR55B at Olkiluoto in 2010 and 2011

International Nuclear Information System (INIS)

Tarvainen, A.-M.; Heikkinen, E.

2011-08-01

Suomen Malmi Oy conducted geophysical drillhole logging as well as optical and acoustic imaging of the drillholes OL-KR54, OL-KR55 and OL-KR55B at the Olkiluoto site in Eurajoki between August 2010 and January 2011. The survey is a part of Posiva Oy's detailed investigation program for the final disposal of spent nuclear fuel. The assignment included the field work and data processing. The report describes field operation, equipment as well as processing procedures and shows the obtained results and an analysis of their quality in the appendices. New focused resistivity, susceptibility, natural gamma and density probes were tested and compared with old probes. This report describes the major features of new probes and the comparison with old probes. The raw and processed data are delivered digitally in WellCAD, PDF and Excel format. (orig.)

The chemistry of chicken manure labelled with 65Zn in the soil

International Nuclear Information System (INIS)

Garcia, G.; L'Annunziata, M.F.; Ortega, M.L.; Alvarado, R.

1979-01-01

The radioactive tracer 65 Zn was used to obtain labelled chicken manure with a view to studying various aspects of the chemical behaviour of zinc in this form of manure, together with some of the transformations occurring after the manure has been incorporated into a sandy soil. During the first stage of the study we obtained the labelled manure from 24 chickens to which 65 Zn with known activity had been orally administered. The manure was collected every 24 hours, with a total of 13 samplings. Having determined the specific activity in each manure sample, we found that roughly 75% of the total activity administered was recovered during the first sampling. Seven different treatments were then tried out, using acrylic columns, including the application of 65 Zn, formaldehyde, sucrose and NH 4 NO 3 , together with labelled and non-labelled chicken manure. These treatments were studied at 45 days of degradation so as to obtain fractions from each of the columns. In the fractions we measured (a) the available 65 Zn; (b) the organic 65 Zn; and (c) the fixed 65 Zn. The data obtained show the virtually zero mobility of the zinc in this soil. The same fractions were used to obtain extracts for the identification and measurement of some of the organic complexes of the zinc, using the following techniques: paper electrophoresis, electrodialysis, filtration using G-10 and G-25 Sephadex gel, and paper chromatography. (author)

27 CFR 19.65 - Experimental distilled spirits plants.

Science.gov (United States)

2010-04-01

... spirits plants. 19.65 Section 19.65 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS DISTILLED SPIRITS PLANTS Administrative and Miscellaneous Provisions Activities Not Subject to This Part § 19.65 Experimental distilled spirits plants. The...

40 CFR 52.65 - Control Strategy: Nitrogen oxides.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Control Strategy: Nitrogen oxides. 52.65 Section 52.65 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Alabama § 52.65 Control Strategy: Nitrogen...

Disagreements with implications: diverging discourses on the ethics of non-medical use of methylphenidate for performance enhancement.

Science.gov (United States)

Forlini, Cynthia; Racine, Eric

2009-07-06

There is substantial evidence that methylphenidate (MPH; Ritalin), is being used by healthy university students for non-medical motives such as the improvement of concentration, alertness, and academic performance. The scope and potential consequences of the non-medical use of MPH upon healthcare and society bring about many points of view. To gain insight into key ethical and social issues on the non-medical use of MPH, we examined discourses in the print media, bioethics literature, and public health literature. Our study identified three diverging paradigms with varying perspectives on the nature of performance enhancement. The beneficial effects of MPH on normal cognition were generally portrayed enthusiastically in the print media and bioethics discourses but supported by scant information on associated risks. Overall, we found a variety of perspectives regarding ethical, legal and social issues related to the non-medical use of MPH for performance enhancement and its impact upon social practices and institutions. The exception to this was public health discourse which took a strong stance against the non-medical use of MPH typically viewed as a form of prescription abuse or misuse. Wide-ranging recommendations for prevention of further non-medical use of MPH included legislation and increased public education. Some positive portrayals of the non-medical use of MPH for performance enhancement in the print media and bioethics discourses could entice further uses. Medicine and society need to prepare for more prevalent non-medical uses of neuropharmaceuticals by fostering better informed public debates.

GAD65 antibodies among Greenland Inuit and its relation to glucose intolerance

DEFF Research Database (Denmark)

Pedersen, Michael Lynge; Bjerregaard, Peter; Jørgensen, Marit Eika

2014-01-01

The aim of this study was to compare the prevalence of circulating Glutamin-Acid-decarboxylase 65 antibodies in a sample of Greenlanders (Inuit) with clinically verified diabetes with samples of participants from a population survey. The study population included participants with known diabetes.......3 % and less than 1 % among Greenlanders without diabetes (p = 0.001). The prevalence of circulating Glutamin-Acid-decarboxylase 65 antibodies among Greenlanders with and without diabetes is relatively low in a global perspective in accordance with one former study among Inuit. Autoimmune diabetes seems...

Comparison of the bony remodelling of two synthetic biomaterials: aragonite 55% and aragonite 55% with active substance

International Nuclear Information System (INIS)

Oudadesse, H; Derrien, A C; Martin, S; Lucas-Girot, A; Cathelineau, G

2007-01-01

In this work, the in vivo behaviour of pure aragonite and vectabone, which is an association of aragonite and an active substance such as gentamicin, was studied to highlight the kinetic resorption of these two biomaterials with 55% of porosity destined for the filling or replacement of bony defects. The synthesis conditions and parameters we used permit us to obtain a biomaterial without a sintering stage. These conditions allow introducing of active substances at the first stage of the elaboration. In this work, the gentamycin antibiotic was associated with calcium carbonate (aragonite 55% with gentamycin) to deliver this active substance on the surgical site for local treatment. The tricalcium phosphate biomaterial was used as the control because of its high biocompatibility. The bony remodelling of these three biomaterials was studied by in vivo experiments. This study was ensured with neutron activation analysis (NAA). The resorption kinetic was elaborated and comparisons of the remodelling biomaterials CaCO 3 55% and CaCO 3 55% with gentamicin (vectabone) and tricalcium phosphate were carried out. The obtained results show that, 6 months after implantation, the mineral composition of vectabone and tricalcium phosphate becomes close to that of young bone. Twelve months after implantation, it becomes similar to that of mature bone

The over-55s and sexual orientation

NARCIS (Netherlands)

Jantine van Lisdonk; Lisette Kuyper

2015-01-01

Original title: 55-plussers en seksuele oriëntatie This report is about lesbian, gay and bisexual (LGB) people aged 55 and over in the Netherlands. Compared with earlier research, we find a striking number of correspondences between LGB and heterosexual people in this age group in terms

A scalable synthesis of 5,5'-dibromo-2,2'-bipyridine and its stepwise functionalization via Stille couplings.

Science.gov (United States)

D'Souza, Daniel M; Leigh, David A; Papmeyer, Marcus; Woltering, Steffen L

2012-11-01

The synthesis of 5,5'-dibromo-2,2'-bipyridine and 5-bromo-2,2'-bipyridine, useful intermediates for elaboration into more complex ligands through metal-catalyzed coupling reactions, can be efficiently conducted on a multigram scale from inexpensive starting materials. The described procedure is reliably scalable and suitable for the synthesis of tens of grams of 5,5'-dibromo-2,2'-bipyridine. 5-Bromo-2,2'-bipyridine is produced as a minor product. The 5,5'-disubstituted-2,2'-bipyridine motif has excellent coordination properties and is a versatile building block for the synthesis of functional materials (including biodiagnostics, photovoltaics and organic light-emitting diodes) and complex molecular topologies (including catenanes and trefoil and pentafoil knots). The selective stepwise functionalization of 5,5'-dibromo-2,2'-bipyridine by consecutive Stille couplings is therefore illustrated and documented in detail. The synthesis of 5,5'-dibromo-2,2'-bipyridine takes 4-5 d: 1 d to prepare the key intermediate 2,2'-bipyridine dihydrobromide, 3 d for its reaction with bromine in a steel bomb reaction vessel and 8 h to isolate and purify the final product.

40 CFR 161.55 - Agricultural vs. non-agricultural pesticides.

Science.gov (United States)

2010-07-01

... pesticides. 161.55 Section 161.55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES General Provisions § 161.55 Agricultural vs. non-agricultural pesticides. Section 25(a)(1) of FIFRA instructs the...

19 CFR 210.65 - Certification of the record.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Certification of the record. 210.65 Section 210.65 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Temporary Relief § 210.65 Certification of the record. When the...

Recommended design correlations for S-65 beryllium

International Nuclear Information System (INIS)

Billone, M.C.

1995-01-01

The properties of tritium and helium behavior in irradiated beryllium are reviewed, along with the thermal-mechanical properties needed for ITER design analysis. Correlations are developed to describe the performance of beryllium in a fusion reactor environment. While this paper focuses on the use of beryllium as a plasma-facing component (PFC) material, the correlations presented here can also be used to describe the performance of beryllium as a neutron multiplier for a tritium breeding blanket. The performance properties for beryllium are subdivided into two categories: properties which do not change with irradiation damage to the bulk of the material; and properties which are degraded by neutron irradiation. The irradiation-independent properties described within are: thermal conductivity, specific heat capacity, thermal expansion, and elastic constants. Irradiation-dependent properties include: yield strength, ultimate tensile strength, plastic tangent modulus, uniform and total tensile elongation, thermal and irradiation-induced creep strength, He-induced swelling and tritium retention/release. The approach taken in developing properties correlations is to describe the behavior of dense, pressed S-65 beryllium -- the material chosen for ITER PFC application -- as a function of temperature. As there are essentially no data on the performance of porous and/or irradiated S-65 beryllium, the degradation of properties with as-fabricated porosity and irradiation are determined from the broad data base on S-200F, as well as other types and grades, and applied to S-65 beryllium by scaling factors. The resulting correlations can be used for Be produced by vacuum hot pressing (VHP) and cold-pressing (CP)/sintering(S)/hot-isostatic-pressing (HIP). The performance of plasma-sprayed beryllium is discussed but not quantified

Phase Curve Analysis of Super-Earth 55 Cancri e

Science.gov (United States)

Angelo, Isabel; Hu, Renyu

2018-01-01

One of the primary questions when characterizing Earth-sized and super-Earth-sized exoplanets is whether they have a substantial atmosphere like Earth and Venus, or a bare-rock surface that may come with a tenuous atmosphere like Mercury. Phase curves of the planets in thermal emission provide clues to this question, because a substantial atmosphere would transport heat more efficiently than a bare-rock surface. Analyzing phase curve photometric data around secondary eclipse has previously been used to study energy transport in the atmospheres of hot Jupiters. Here we use phase curve, Spitzer time-series photometry to study the thermal emission properties of the super-Earth exoplanet 55 Cancri e. We utilize a previously developed semi-analytical framework to fit a physical model to infrared photometric data of host star 55 Cancri from the Spitzer telescope IRAC 2 band at 4.5 μm. The model uses various parameters of planetary properties including Bond albedo, heat redistribution efficiency (i.e., the ratio between the radiative timescale and advective timescale of the photosphere), and atmospheric greenhouse factor. The phase curve of 55 Cancri e is dominated by thermal emission with an eastward-shifted hot spot located on the planet surface. We determine the heat redistribution efficiency to be ≈1.47, which implies that the advective timescale is on the same order as the radiative timescale. This requirement from the phase curve cannot be met by the bare-rock planet scenario, because heat transport by currents of molten lava would be too slow. The phase curve thus favors the scenario with a substantial atmosphere. Our constraints on the heat redistribution efficiency translate to a photosphere pressure of ~1.4 bar. The Spitzer IRAC 2 band is thus a window into the deep atmosphere of the planet 55 Cancri e.

40 CFR 79.55 - Base fuel specifications.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Base fuel specifications. 79.55... (CONTINUED) REGISTRATION OF FUELS AND FUEL ADDITIVES Testing Requirements for Registration § 79.55 Base fuel specifications. (a) General Characteristics. (1) The base fuel(s) in each fuel family shall serve as the group...

9 CFR 55.7 - Claims not allowed.

Science.gov (United States)

2010-01-01

... owner in violation of a law or regulation administered by the Secretary regarding animal disease, or in... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Claims not allowed. 55.7 Section 55.7 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...

Extinction memory is facilitated by methylphenidate and regulated by dopamine and noradrenaline receptors.

Science.gov (United States)

Furini, Cristiane R G; Behling, Jonny A K; Zinn, Carolina G; Zanini, Mara Lise; Assis Brasil, Eduardo; Pereira, Luiza Doro; Izquierdo, Ivan; de Carvalho Myskiw, Jociane

2017-05-30

Extinction is defined as the learned inhibition of retrieval and is the mainstay of exposure therapy, which is widely used to treat drug addiction, phobias and fear disorders. The psychostimulant, methylphenidate (MPH) is known to increase extracellular levels of noradrenaline and dopamine by blocking their reuptake and studies have demonstrated that MPH can modulate hippocampal physiology and/or functions including long-term potentiation (LTP), learning and memory. However, the influence of MPH on fear extinction memory has been insufficiently studied. Here we investigate the effect of MPH infused into the CA1 region of the hippocampus on extinction memory in animals normally incapable of showing contextual fear conditioning (CFC) extinction because of weak training, and the possible mechanisms through which it acts during this process. For this, male Wistar rats with infusion cannulae stereotaxically implanted in the CA1 region were submitted to a weak extinction protocol in a CFC apparatus. Animals that received intra-CA1 infusion of MPH (12.5μg/side) 20min before the extinction training (Ext Tr) expressed less freezing behavior than Veh-treated animals during both Ext Tr and extinction retention Test (Ext Test). Additionally, the administration of MPH+Timolol (1μg/side) or MPH+SCH23390 (1.5μg/side) intra-CA1 20min before the Ext Tr blocked the enhancing effect of the MPH on extinction learning. These results suggest that MPH in the CA1 region of the hippocampus is able to induce the consolidation of extinction memory and this process occurs through both β-adrenergic and D1/D5 dopaminergic receptors. Copyright © 2017 Elsevier B.V. All rights reserved.

33 CFR 118.65 - Lights on fixed bridges.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lights on fixed bridges. 118.65 Section 118.65 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.65 Lights on fixed bridges. (a) Each fixed bridge span over a navigable...

46 CFR 167.65-25 - Steering gear tests.

Science.gov (United States)

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Steering gear tests. 167.65-25 Section 167.65-25... SHIPS Special Operating Requirements § 167.65-25 Steering gear tests. On all nautical school ships making voyages of more than 48 hours' duration, the entire steering gear, the whistle, the means of...

7 CFR 301.55-2 - Regulated articles.

Science.gov (United States)

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false Regulated articles. 301.55-2 Section 301.55-2... Regulated articles. The following are regulated articles: (a) The South American cactus moth, in any living..., Nopalea, and Opuntia. (c) Any other product, article, or means of conveyance not listed in paragraphs (a...

Cobalt-55 positron emission tomography in recurrent ischaemic stroke

NARCIS (Netherlands)

De Reuck, J; Santens, P; Keppens, J; De Bleecker, J; Strijckmans, K; Goethals, P; Lemahieu, [No Value; Korf, J

The present study investigates if Cobalt-55 (Co-55) positron emission tomography (PET) allows us to distinguish and detect recent, recurrent strokes in patients who had already suffered a previous infarct in the same vascular territory. Fourteen patients with recurrent strokes underwent a Co-55 PET

31 CFR 8.55 - Contents of complaint.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Contents of complaint. 8.55 Section 8.55 Money and Finance: Treasury Office of the Secretary of the Treasury PRACTICE BEFORE THE BUREAU OF... he or she is able to prepare a defense. (b) Demand for answer. The complaint will give notification...

Determination of the Np(IV)-Np(III) normal potential in fused LiCl-CsCl (55-45%) by absorption spectrophotometry

International Nuclear Information System (INIS)

Lysy, R.; Duyckaerts, G.

1977-01-01

The following reaction Np 4+ + 1/2 H 2 + Cl - reversible Np 3+ + HCl has been studied quantitatively in fused LiCl-CsCl (55-45 mol %) in the temperature range of 450-600 0 C, by visible and near IR absorption spectrophotometry. At 450 deg C, the equilibrium constant equals K = 7.4 atmsup(1/2). The mean values of ΔH and ΔS in the temperature range of 450-600 deg C are: ΔH = (35.6+-10.3) kJ mol -1 , ΔS=(65.5+-13.0)J mol -1 K -1 [fr

20 CFR 222.55 - When a stepchild is dependent.

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2010-04-01

... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When a stepchild is dependent. 222.55 Section 222.55 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Child Support and Dependency § 222.55 When a stepchild is dependent. An employee's...

Indigenous design and fabrication of a 6.5 T superconducting ...

Indian Academy of Sciences (India)

This includes a 6.5 T superconducting magnet and a vari- able temperature .... tronics) Hall sensor (of sensitivity ~10 µV/Oe at 5 mA DC excitation) by moving it to various axial positions and the measured coil constant is found to be very close ... developed across the magnet makes either of the diodes to conduct and allows.

14 CFR 183.55 - Limitations.

Science.gov (United States)

2010-01-01

... REGULATIONS REPRESENTATIVES OF THE ADMINISTRATOR Organization Designation Authorization § 183.55 Limitations... structure), no Unit member may perform that function until the Administrator is notified of the change, and...

Determinants of adherence to methylphenidate and the impact of poor adherence on maternal and family measures.

Science.gov (United States)

Gau, Susan S F; Shen, Hsin-Yi; Chou, Miao-Churn; Tang, Ching-Shu; Chiu, Yen-Nan; Gau, Churn-Shiouh

2006-06-01

The aim of this study was to examine the association between adherence to immediate-release methylphenidate (IR MPH) and maternal psychological distress, parenting style, parent- child relationship, and perceived family support. The sample consisted of 307 children with attention-deficit hyperactivity disorder (ADHD) (271 boys and 36 girls), 6-17 years of age, who had been treated with IR MPH for the past 6 months. The measures included the Chinese Health Questionnaire, Parental Bonding Instrument, Family APGAR, and Home Behaviors of the Social Adjustment Inventory for Children and Adolescents. Reasons for poor adherence (n = 79; 25.7%) included forgetting medication (72.7%), the medication having no effect (20.0%), and refusing medication (12.7%). Increased age and three-times-daily administration were the major predictors for poor adherence to IR MPH. Poor adherence was associated with increased degree of maternal psychological distress, indifferent parenting, maternal overprotection/control, poor family support, decreased interaction with parents, and increased problems at home. Findings indicate that multiple daily dosing of MPH increases the likelihood of poor adherence, particularly in adolescents, and that poor adherence is associated with impaired maternal/family process. Once-daily administration of MPH is necessary to improve adherence and to decrease the possible exacerbation of tense parent-child relationships caused by poor drug adherence.

Disagreements with implications: diverging discourses on the ethics of non-medical use of methylphenidate for performance enhancement

Science.gov (United States)

Forlini, Cynthia; Racine, Eric

2009-01-01

Background There is substantial evidence that methylphenidate (MPH; Ritalin), is being used by healthy university students for non-medical motives such as the improvement of concentration, alertness, and academic performance. The scope and potential consequences of the non-medical use of MPH upon healthcare and society bring about many points of view. Methods To gain insight into key ethical and social issues on the non-medical use of MPH, we examined discourses in the print media, bioethics literature, and public health literature. Results Our study identified three diverging paradigms with varying perspectives on the nature of performance enhancement. The beneficial effects of MPH on normal cognition were generally portrayed enthusiastically in the print media and bioethics discourses but supported by scant information on associated risks. Overall, we found a variety of perspectives regarding ethical, legal and social issues related to the non-medical use of MPH for performance enhancement and its impact upon social practices and institutions. The exception to this was public health discourse which took a strong stance against the non-medical use of MPH typically viewed as a form of prescription abuse or misuse. Wide-ranging recommendations for prevention of further non-medical use of MPH included legislation and increased public education. Conclusion Some positive portrayals of the non-medical use of MPH for performance enhancement in the print media and bioethics discourses could entice further uses. Medicine and society need to prepare for more prevalent non-medical uses of neuropharmaceuticals by fostering better informed public debates. PMID:19580661

Disagreements with implications: diverging discourses on the ethics of non-medical use of methylphenidate for performance enhancement

Directory of Open Access Journals (Sweden)

Racine Eric

2009-07-01

Full Text Available Abstract Background There is substantial evidence that methylphenidate (MPH; Ritalin, is being used by healthy university students for non-medical motives such as the improvement of concentration, alertness, and academic performance. The scope and potential consequences of the non-medical use of MPH upon healthcare and society bring about many points of view. Methods To gain insight into key ethical and social issues on the non-medical use of MPH, we examined discourses in the print media, bioethics literature, and public health literature. Results Our study identified three diverging paradigms with varying perspectives on the nature of performance enhancement. The beneficial effects of MPH on normal cognition were generally portrayed enthusiastically in the print media and bioethics discourses but supported by scant information on associated risks. Overall, we found a variety of perspectives regarding ethical, legal and social issues related to the non-medical use of MPH for performance enhancement and its impact upon social practices and institutions. The exception to this was public health discourse which took a strong stance against the non-medical use of MPH typically viewed as a form of prescription abuse or misuse. Wide-ranging recommendations for prevention of further non-medical use of MPH included legislation and increased public education. Conclusion Some positive portrayals of the non-medical use of MPH for performance enhancement in the print media and bioethics discourses could entice further uses. Medicine and society need to prepare for more prevalent non-medical uses of neuropharmaceuticals by fostering better informed public debates.

Gene Expression of Tumor Necrosis Factor α and TNF-α Receptors (p55 and p75) in Nonalcoholic Steatohepatitis Patients

International Nuclear Information System (INIS)

Soliman, S.ET.; Abo-Madyan, A.A.

2010-01-01

The main objective of this study was to analyze the pathogenic role of the tumor necrosis factor (TNF-) system in the development of nonalcoholic steatohepatitis (NASH). Fifty obese patients were studied. We investigated: 1) the expression of mRNA of TNF- and their p55 and p75 receptors by quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) in hepatic and adipose tissues; and 2) the relationship between TNF-, p55, and p75 and the severity of NASH. Obese patients without NASH were the control group. A remarkable increase in the expression of mRNA of TNF- was found in patients with NASH in hepatic tissue (0.65 ± 0.54) and in peripheral fat (0.43 ± 0.45); in the control samples, the mRNA expression was 0.30 ± 0.32, P < .006, and 0.28 ± 0.22, P < .016, respectively. Furthermore, we found significant increase in the mRNA levels of p55 receptor (2.94 ± 1.71 vs. 1.46 ± 1.27; P<.04); however, the mRNA expression of the p75 receptor was similar in both patients. Those patients with NASH with significant fibrosis presented an increase in the expression of mRNA TNF- in comparison with those with slight or nonexistent fibrosis. The levels of mRNA-p55 are increased in the liver tissue of NASH patients. This over expression is more elevated in patients with more advanced NASH. These findings suggest that the TNF- system may be involved in the pathogenesis of NASH.

Monitoring of tritium-contaminated surfaces, including skin

International Nuclear Information System (INIS)

Surette, R.A.; Wood, M.J.

1994-05-01

We have examined various commercially available tritium surface contamination monitors along with different swipe media and techniques for direct and indirect (swipe) monitoring of contaminated surfaces, including skin. None of the methods or instruments evaluated were more sensitive than the swipe and liquid scintillation counting (LSC) method. Swipe measurements with open-window proportional counters were, in general, less than half as sensitive as LSC, but have the advantages of having the results available almost immediately, and no sample preparation is required. The Nuclear Measurement Corporation's PC-55 is the most suitable instrument we tested for the analysis of routine swipe measurement. The PC-55 was about one third as sensitive as LSC when used with Ontario Hydro filter paper swipe media. Surface contamination measurement results can be obtained within minutes using the PC-55, compared to hours using LSC. The selection of swipe media for use with proportional counter-based instruments is critical. A medium that is electrically insulating can develop an electrostatic charge on its surface; this may alter the field gradient in the detector and may adversely influence the results. Although the PC-55 is sufficiently sensitive and very convenient, operational experience with the instrument is needed before recommending that it replace current LSC methods. The PC-55's susceptibility to internal tritium contamination may limit its practical usefulness. Because of the complexity of using live animals to evaluate direct and indirect methods for assessing skin contamination, pig skin was investigated as a possible substitute. We concluded that, for the first few hours post-exposure, pig skin mimics the kinetics of animal skin that has contacted a tritium-contaminated surface. (author). 30 refs., 1 tab., 7 figs

46 CFR 112.55-15 - Capacity of storage batteries.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Capacity of storage batteries. 112.55-15 Section 112.55... LIGHTING AND POWER SYSTEMS Storage Battery Installation § 112.55-15 Capacity of storage batteries. (a) A storage battery for an emergency lighting and power system must have the capacity— (1) To close all...

Accumulation of 65Zn by octopus Octopus vulgaris

International Nuclear Information System (INIS)

Ueda, Taiji; Nakahara, Motokazu; Nakamura, Ryoichi; Suzuki, Yuzuru; Shimizu, Chiaki.

1985-01-01

In order to aim the prevention of the radiation hazard to human beings through sea food, the accumulation and excretion of 65 Zn by octopus Octopus vulgaris was examined by the radioisotope tracer experiment. The concentration factor of 65 Zn for whole body of the octopus that take up the nuclide from sea water and food was estimated as 9,900, by assuming that the octopus feeds on clams alone. In that case the contribution of food was about twenty times greater than that of sea water on the accumulation of the nuclide. The biological half-life of 65 Zn accumulated through sea water was 74 days. High accumulation of 65 Zn in the branchial heart of the octopus, as in the case of Co, was not observed. In the liver, 65 Zn combined with three constituents which have a molecular weight of more than 80,000, 7,000 - 8,000 and less than 5,000. In the kidney, 65 Zn combined with three constituents of a molecular weight of more than 80,000, 10,000 - 20,000 and less than 5,000. (author)

39 CFR 6.5 - Minutes of meetings.

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2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Minutes of meetings. 6.5 Section 6.5 Postal Service UNITED STATES POSTAL SERVICE THE BOARD OF GOVERNORS OF THE U.S. POSTAL SERVICE MEETINGS (ARTICLE...) or 39 U.S.C. 410(c). ...

28 CFR 540.65 - Release of information.

Science.gov (United States)

2010-07-01

... 540.65 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT CONTACT WITH PERSONS IN THE COMMUNITY Contact With News Media § 540.65 Release of information. (a) The... media. Examples are deaths, inside escapes, and institution emergencies. (b) The Warden shall provide...

40 CFR 68.65 - Process safety information.

Science.gov (United States)

2010-07-01

... (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Program 3 Prevention Program § 68.65 Process safety... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Process safety information. 68.65... compilation of written process safety information before conducting any process hazard analysis required by...

Why work beyond 65? Discourse on the Decision to Continue Working or Retire Early

Directory of Open Access Journals (Sweden)

Kerstin Nilsson

2012-08-01

Full Text Available This study examined retirement decisions among people who had left working life before 65 years of age and those working beyond 65 years in an extended working life. The results were used to make a model about their considerations, weighting and decision making, and important factors and themes in working beyond 65 years of age or retiring before 65. The interviewees seemed to have considered and weighed their own best life balance to finally result in their identity as (older worker or early retiree. They included their work situation and social surroundings in descriptions of their planning and retirement decision making. The most important themes in these descriptions were (i personal health and well-being; (ii personal finances; (iii possibilities for social inclusion; and (iv possibilities for self-crediting by meaningful activities. Those identifying themselves as older workers had possibilities in their life situation to manage their work in relation to their functional ageing and health situation; felt important to others and socially included in the workplace; and did meaningful tasks and felt empowered in their working life. Those who had left the working life before 65 years of age describe a better possibility to this outside the working life and left as soon as they acquire a sufficient pension. The results and model presented here on how people perceive their identity as older worker or early retiree will hopefully contribute to understanding retirement planning and to the formulation of strategies to extend working life.

Selective uptake of 55Fe from seawater by zooplankton

International Nuclear Information System (INIS)

Jennings, C.D.

1978-01-01

Iron-55 was measured in water and mixed zooplankton collected in the South Pacific Ocean. The ratios of the specific activity of 55 Fe (pCi/g Fe) between plankton and water from the same locations appear to be about 100, which suggests that zooplankton took up 55 Fe in preference to stable iron in the South Pacific Ocean

[Exploring the prospects for general practitioners over 55 years old from three counties of western France].

Science.gov (United States)

Robino, Stéphane; Buis, Hélène; Delansorne, Fanny; Tomas, Josiane; Huez, Jean-François; La Combe, Antoine; Fanello, Serge

2009-01-01

Medical demography and the practice of medicine will be influenced by the personal plans of GPs and their decisions to stop practicing in the coming years. This study aims to understand the events that could potentially worsen the medical demography in terms of shortages of GPs for primary care in the short term. 455 GPs (all aged over 55 years) practicing in three districts of western France were selected to participate in this prospective study. 258 valid and complete questionnaires (56%) were received. With the use of a special programme, SPSS version 1.5, an overall comprehensive analysis and one by geographical sub-regional groups were performed. When queried about their plans or wishes for their practice between the present time and their age of 65, of the responding physicians, 27% wanted to continue working under the same conditions, 10% were undecided, and 63% wanted to stop or adjust their professional activity before age 65. The main reasons and factors motivating these plans were their current time constraints, the workload related to administrative tasks and the continuity of care; moreover, GPs noted the demands and expectations of patients, professional burnout and difficulties in obtaining a healthy work-life balance as factors contributing to these plans. Physicians who wanted to stop practicing (30%) were the least satisfied with their work and seem to have anticipated this plan of action given that they reduced their number of hours in the office and on-call. Those who wish to adapt their work time (33%) are for the most part satisfied even if they work more, but 70% want to reduce their work hours. The impact of these projects is a potentially heavy one, especially since two of the counties concerned have a low medical density and high rate of practicing physicians. Government measures currently proposed do not seem to respond to the evolution of private practice expected by GPs over 55 years.

7 CFR 927.65 - Exemption from regulation.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Exemption from regulation. 927.65 Section 927.65 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... for either of such purposes from entering commercial channels of trade contrary to the provisions of...

IPP-rich milk protein hydrolysate lowers blood pressure in subjects with stage 1 hypertension, a randomized controlled trial

Directory of Open Access Journals (Sweden)

Kloek Joris

2010-11-01

Full Text Available Abstract Background Milk derived peptides have been identified as potential antihypertensive agents. The primary objective was to investigate the effectiveness of IPP-rich milk protein hydrolysates (MPH on reducing blood pressure (BP as well as to investigate safety parameters and tolerability. The secondary objective was to confirm or falsify ACE inhibition as the mechanism underlying BP reductions by measuring plasma renin activity and angiotensin I and II. Methods We conducted a randomized, placebo-controlled, double blind, crossover study including 70 Caucasian subjects with prehypertension or stage 1 hypertension. Study treatments consisted of daily consumption of two capsules MPH1 (each containing 7.5 mg Isoleucine-Proline-Proline; IPP, MPH2 (each containing 6.6 mg Methionine-Alanine-Proline, 2.3 mg Leucine-Proline-Proline, 1.8 mg IPP, or placebo (containing cellulose for 4 weeks. Results In subjects with stage 1 hypertension, MPH1 lowered systolic BP by 3.8 mm Hg (P = 0.0080 and diastolic BP by 2.3 mm Hg (P = 0.0065 compared with placebo. In prehypertensive subjects, the differences in BP between MPH1 and placebo were not significant. MPH2 did not change BP significantly compared with placebo in stage I hypertensive or prehypertensive subjects. Intake of MPHs was well tolerated and safe. No treatment differences in hematology, clinical laboratory parameters or adverse effects were observed. No significant differences between MPHs and placebo were found in plasma renin activity, or angiotensin I and II. Conclusions MPH1, containing IPP and no minerals, exerts clinically relevant BP lowering effects in subjects with stage 1 hypertension. It may be included in lifestyle changes aiming to prevent or reduce high BP. Trial registration ClinicalTrials.gov NCT00471263

The 'tubulin-like' S1 protein of Spirochaeta is a member of the hsp65 stress protein family

Science.gov (United States)

Munson, D.; Obar, R.; Tzertzinis, G.; Margulis, L.

1993-01-01

A 65-kDa protein (called S1) from Spirochaeta bajacaliforniensis was identified as 'tubulin-like' because it cross-reacted with at least four different antisera raised against tubulin and was isolated, with a co-polymerizing 45-kDa protein, by warm-cold cycling procedures used to purify tubulin from mammalian brain. Furthermore, at least three genera of non-cultivable symbiotic spirochetes (Pillotina, Diplocalyx, and Hollandina) that contain conspicuous 24-nm cytoplasmic tubules displayed a strong fluorescence in situ when treated with polyclonal antisera raised against tubulin. Here we summarize results that lead to the conclusion that this 65-kDa protein has no homology to tubulin. S1 is an hsp65 stress protein homologue. Hsp65 is a highly immunogenic family of hsp60 proteins which includes the 65-kDa antigens of Mycobacterium tuberculosis (an active component of Freund's complete adjuvant), Borrelia, Treponema, Chlamydia, Legionella, and Salmonella. The hsp60s, also known as chaperonins, include E. coli GroEL, mitochondrial and chloroplast chaperonins, the pea aphid 'symbionin' and many other proteins involved in protein folding and the stress response.

17 CFR 201.65 - Identity and signature.

Science.gov (United States)

2010-04-01

... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Identity and signature. 201.65... of 1934 § 201.65 Identity and signature. Applications pursuant to this subpart may omit the identity, mailing address, and signature of the applicant; provided, that such identity, mailing address and...

32 CFR 842.65 - Claims not payable.

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2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Claims not payable. 842.65 Section 842.65 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE CLAIMS AND LITIGATION... costs. (d) Accrues from a private contractual relationship between US personnel and third parties about...

9 CFR 113.65 - Brucella Abortus Vaccine.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Brucella Abortus Vaccine. 113.65... Bacterial Vaccines § 113.65 Brucella Abortus Vaccine. Brucella Abortus Vaccine shall be prepared as a desiccated live culture bacterial vaccine from smooth colonial forms of the Brucella abortus organism...

21 CFR 10.65 - Meetings and correspondence.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Meetings and correspondence. 10.65 Section 10.65 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... religion. (e) An official transcript, recording, or memorandum summarizing the substance of any meeting...

46 CFR 97.15-55 - Requirements for fuel oil.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Requirements for fuel oil. 97.15-55 Section 97.15-55... OPERATIONS Tests, Drills, and Inspections § 97.15-55 Requirements for fuel oil. (a) It shall be the duty of the chief engineer to cause an entry in the log to be made of each supply of fuel oil received on...

The ecological behaviour of 55Fe in plants and in the flesh of cattle and game

International Nuclear Information System (INIS)

Barwinek, F.; Kreuzer, W.; Sansoni, B.; Kernforschungsanlage Juelich G.m.b.H.

1980-01-01

98 samples of shrub lichens taken between 1965 and 1970, including 69 from the Federal Republic of Germany and 15 from Finland, mainly of the genus Cladonia, particularly the species Cladonia rangiferina and Cladonia silvatica, 5 samples of moss, 2 of heather and 4 of hay, and also meat samples taken from 12 Bavarian cattle slaughtered in the spring of 1970, 7 stags killed in the Eastern Carpathians in the autumn of 1969 and one chamois shot in the Lower Tauern mountains in the autumn of 1970, were all analysed for their contents of 55 Fe and stable Fe. The lichens contained between 0.7 - in 1970 - and a maximum of 139.0 nCi 55 Fe/kg dry matter - in 1965, or between 0.09 and 6.9 nCi/g ash. Their stable Fe contents varied between 0.234 and 1.990 mg/g dry matter or between 16.3 and 59.7 mg/Fe/g ash. Specific 55 Fe activities of between 231 pCi 55 Fe/mg Fe (1964) and 1.6 pCi 55 Fe/mg Fe (1970) can be calculated from these values. There were no obvious differences between the 55 Fe contamination of lichens of different species. This was also true of their contents of stable Fe. Cladonia furcata had the highest contents of 55 Fe and stable Fe, both relatively and absolutely. From 1965 onwards the 55 Fe-activities in the lichens examined declined in line with the drop in 55 Fe in the fall-out. (orig./AJ.) [de

The HANDSS-55 Linking Equipment

International Nuclear Information System (INIS)

Crosby, S.

2001-01-01

The Bucket Translation Unit (BTU) and the Drum Handler are two of the HANDSS-55 subsystems identified as linking components. Both subsystems link other modules together by moving material to or from another module

Replication-dependent 65R→K reversion in human immunodeficiency virus type 1 reverse transcriptase double mutant K65R + L74V

International Nuclear Information System (INIS)

Sharma, Prem L.; Nurpeisov, Viktoria; Lee, Kimberly; Skaggs, Sara; Di San Filippo, Christina Amat; Schinazi, Raymond F.

2004-01-01

Understanding of the mechanisms of interaction among nucleoside reverse transcriptase inhibitor (NRTI)-selected mutations in the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) coding sequence is essential for the design of newer drugs and for enhancing our vision of the structure function relationship among amino acids of the polymerase domain of HIV-1. Although several nucleoside reverse transcriptase inhibitors select RT mutations K65R and L74V, the combination of 65R + 74V is rare in clinics. A novel NRTI (-)-β-D-dioxolane-guanosine (DXG) is known to select in vitro either the 65R or 74V mutant virus (Antimicrob. Agents Chemother. 44 (2000) 1783). These mutations were not selected together during repeated passaging of the HIV-1 in the presence of this drug. To analyze the impact of these RT mutations on viral replication, a double mutant containing K65R + L74V was created by site-directed mutagenesis in a pNL4-3 background. Replication kinetic assays revealed that the mutant K65R + L74V is unstable, and 65R→K reversion occurs during replication of virus in phytohemagglutinin (PHA)-stimulated human peripheral blood mononuclear (PBM) cells in the absence of selection pressure. Replication kinetic assays in MT-2 cells demonstrated that double mutant 65R + 74V is highly attenuated for replication and the initiation of reversion is related to the increase in RT activity. Additionally, the suppression of viral replication in the presence of DXG or under suboptimal human recombinant interleukin-2 leads to minimal or no 65R→K reversion. These observations provide evidence that 65R→K reversion in the double mutant 65R + 74V is dependent on a specific rate of viral replication in a pNL4-3 background. A similar phenomenon may occur in vivo, which may have implications for treatment management strategies

40 CFR 65.46 - Alternative means of emission limitation.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Alternative means of emission limitation. 65.46 Section 65.46 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Storage Vessels § 65.46 Alternative means of emission...

Jõgevamaa ettevõtete TOP 55

Index Scriptorium Estoniae

2004-01-01

Jõgevamaa ettevõtete TOP 55 aastal 2003. Käibe TOP 40. Kasumi TOP 40. Käibe kasvu TOP 20. Kasumi kasvu TOP 20. Rentaabluse TOP 20. Omakapitali tootlikkuse TOP 20. Jõgevamaa firmade üld- ja finantsandmed

Monitoring of tritium-contaminated surfaces, including skin

Energy Technology Data Exchange (ETDEWEB)

Surette, R A; Wood, M J

1994-05-01

We have examined various commercially available tritium surface contamination monitors along with different swipe media and techniques for direct and indirect (swipe) monitoring of contaminated surfaces, including skin. None of the methods or instruments evaluated were more sensitive than the swipe and liquid scintillation counting (LSC) method. Swipe measurements with open-window proportional counters were, in general, less than half as sensitive as LSC, but have the advantages of having the results available almost immediately, and no sample preparation is required. The Nuclear Measurement Corporation`s PC-55 is the most suitable instrument we tested for the analysis of routine swipe measurement. The PC-55 was about one third as sensitive as LSC when used with Ontario Hydro filter paper swipe media. Surface contamination measurement results can be obtained within minutes using the PC-55, compared to hours using LSC. The selection of swipe media for use with proportional counter-based instruments is critical. A medium that is electrically insulating can develop an electrostatic charge on its surface; this may alter the field gradient in the detector and may adversely influence the results. Although the PC-55 is sufficiently sensitive and very convenient, operational experience with the instrument is needed before recommending that it replace current LSC methods. The PC-55`s susceptibility to internal tritium contamination may limit its practical usefulness. Because of the complexity of using live animals to evaluate direct and indirect methods for assessing skin contamination, pig skin was investigated as a possible substitute. We concluded that, for the first few hours post-exposure, pig skin mimics the kinetics of animal skin that has contacted a tritium-contaminated surface. (author). 30 refs., 1 tab., 7 figs.

28 CFR 51.55 - Consistency with constitutional and statutory requirements.

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2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Consistency with constitutional and statutory requirements. 51.55 Section 51.55 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED... the Attorney General § 51.55 Consistency with constitutional and statutory requirements. (a...

Improvement of the homogeneity of protein-imprinted polymer films by orientated immobilization of the template

Energy Technology Data Exchange (ETDEWEB)

Liu Lijian; Zheng Jingjing; Fang Guijie [Key Laboratory of Fermentation Engineering (Ministry of Education), College of Bioengineering, Hubei University of Technology, Nanhu Li Jia Dun 1, Wuhan 430068 (China); Xie Weihong, E-mail: weihong.xie@yahoo.com.cn [Key Laboratory of Fermentation Engineering (Ministry of Education), College of Bioengineering, Hubei University of Technology, Nanhu Li Jia Dun 1, Wuhan 430068 (China)

2012-05-13

Highlights: Black-Right-Pointing-Pointer MPH was genetically modified at its C-terminal with (Gly-Ser){sub 5}-Cys. Black-Right-Pointing-Pointer MPH-L was immobilized with fixed orientation via disulfide chemistry. Black-Right-Pointing-Pointer The immobilized MPH-L retained the activity of MPH. Black-Right-Pointing-Pointer MPH-L formed a homogeneous template. Black-Right-Pointing-Pointer Homogeneous MIP film was obtained with orientated immobilization of the template. - Abstract: A method for preparing homogeneous protein-imprinted polymer films with orientated immobilization of template is described. The template methyl parathion hydrolase (MPH) was modified with a peptide linker (Gly-Ser){sub 5}-Cys and was immobilized on a cover glass with a fixed orientation via the linker. The activity of the fusion enzyme (MPH-L) was evaluated by determining the product's absorbance at 405 nm (A{sub 405}). Both the free and the immobilized MPH-L showed higher retention of the bioactivity than the wide type enzyme (MPH-W) as revealed by the A{sub 405} values for MPH-L{sub free}/MPH-W{sub free} (1.159/1.111) and for MPH-L{sub immobilized}/MPH-W{sub immobilized} (0.348/0.118). The immobilized MPH-L also formed a more homogeneous template stamp compared to the immobilized MPH-W. The molecularly imprinted polymer films prepared with the immobilized MPH-L exhibited high homogeneity with low Std. Deviations of 80 and 200 from the CL intensity mean volumes which were observed for batch-prepared films and an individual film, respectively. MPH-L-imprinted polymer film also had a larger template binding capacity indicated by higher CL intensity mean volume of 3900 INT over 2500 INT for MPH-W-imprinted films. The imprinted film prepared with the orientated immobilization of template showed an imprinting factor of 1.7, while the controls did not show an imprinting effect.

Improvement of the homogeneity of protein-imprinted polymer films by orientated immobilization of the template

International Nuclear Information System (INIS)

Liu Lijian; Zheng Jingjing; Fang Guijie; Xie Weihong

2012-01-01

Highlights: ► MPH was genetically modified at its C-terminal with (Gly-Ser) 5 –Cys. ► MPH-L was immobilized with fixed orientation via disulfide chemistry. ► The immobilized MPH-L retained the activity of MPH. ► MPH-L formed a homogeneous template. ► Homogeneous MIP film was obtained with orientated immobilization of the template. - Abstract: A method for preparing homogeneous protein-imprinted polymer films with orientated immobilization of template is described. The template methyl parathion hydrolase (MPH) was modified with a peptide linker (Gly-Ser) 5 –Cys and was immobilized on a cover glass with a fixed orientation via the linker. The activity of the fusion enzyme (MPH-L) was evaluated by determining the product's absorbance at 405 nm (A 405 ). Both the free and the immobilized MPH-L showed higher retention of the bioactivity than the wide type enzyme (MPH-W) as revealed by the A 405 values for MPH-L free /MPH-W free (1.159/1.111) and for MPH-L immobilized /MPH-W immobilized (0.348/0.118). The immobilized MPH-L also formed a more homogeneous template stamp compared to the immobilized MPH-W. The molecularly imprinted polymer films prepared with the immobilized MPH-L exhibited high homogeneity with low Std. Deviations of 80 and 200 from the CL intensity mean volumes which were observed for batch-prepared films and an individual film, respectively. MPH-L-imprinted polymer film also had a larger template binding capacity indicated by higher CL intensity mean volume of 3900 INT over 2500 INT for MPH-W-imprinted films. The imprinted film prepared with the orientated immobilization of template showed an imprinting factor of 1.7, while the controls did not show an imprinting effect.

30 CFR 256.65 - Attorney General review.

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2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Attorney General review. 256.65 Section 256.65... give due consideration to the views of the Attorney General. The Secretary may act on an assignment or transfer if the Attorney General has not responded to the request for consultation within 30 days of said...

Deletion of Gpr55 Results in Subtle Effects on Energy Metabolism, Motor Activity and Thermal Pain Sensation.

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Mikael Bjursell

Full Text Available The G-protein coupled receptor 55 (GPR55 is activated by cannabinoids and non-cannabinoid molecules and has been speculated to play a modulatory role in a large variety of physiological and pathological processes, including in metabolically perturbed states. We therefore generated male mice deficient in the gene coding for the cannabinoid/lysophosphatidylinositol (LPI receptor Gpr55 and characterized them under normal dietary conditions as well as during high energy dense diet feeding followed by challenge with the CB1 receptor antagonist/GPR55 agonist rimonabant. Gpr55 deficient male mice (Gpr55 KO were phenotypically indistinguishable from their wild type (WT siblings for the most part. However, Gpr55 KO animals displayed an intriguing nocturnal pattern of motor activity and energy expenditure (EE. During the initial 6 hours of the night, motor activity was significantly elevated without any significant effect observed in EE. Interestingly, during the last 6 hours of the night motor activity was similar but EE was significantly decreased in the Gpr55 KO mice. No significant difference in motor activity was detected during daytime, but EE was lower in the Gpr55 KO compared to WT mice. The aforementioned patterns were not associated with alterations in energy intake, daytime core body temperature, body weight (BW or composition, although a non-significant tendency to increased adiposity was seen in Gpr55 KO compared to WT mice. Detailed analyses of daytime activity in the Open Field paradigm unveiled lower horizontal activity and rearing time for the Gpr55 KO mice. Moreover, the Gpr55 KO mice displayed significantly faster reaction time in the tail flick test, indicative of thermal hyperalgesia. The BW-decreasing effect of rimonabant in mice on long-term cafeteria diet did not differ between Gpr55 KO and WT mice. In conclusion, Gpr55 deficiency is associated with subtle effects on diurnal/nocturnal EE and motor activity behaviours but does not

Genome Sequence of the Thermophilic Cyanobacterium Thermosynechococcus sp. Strain NK55a.

Energy Technology Data Exchange (ETDEWEB)

Stolyar, Sergey; Liu, Zhenfeng; Thiel, Vera; Tomsho, Lynn P.; Pinel, Nicolas; Nelson, William C.; Lindemann, Stephen R.; Romine, Margaret F.; Haruta, Shin; Schuster, Stephan C.; Bryant, Donald A.; Fredrickson, Jim K.

2014-01-02

The genome of the unicellular cyanobacterium, Thermosynechococcus sp. strain NK55a, isolated from Nakabusa hot spring, comprises a single, circular, 2.5-Mb chromosome. The genome is predicted to encode 2358 protein coding genes, including genes for all typical cyanobacterial photosynthetic and metabolic functions. No genes encoding hydrogenases or nitrogenase were identified.

40 CFR 60.55c - Waste management plan.

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2010-07-01

... management plan shall identify both the feasibility and the approach to separate certain components of solid... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Waste management plan. 60.55c Section 60.55c Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED...

41 CFR 105-55.005 - Form of payment.

Science.gov (United States)

2010-07-01

... Administration 55-COLLECTION OF CLAIMS OWED THE UNITED STATES § 105-55.005 Form of payment. Claims may be paid in the form of money or, when a contractual basis exists, the General Services Administration may demand the return of specific property or the performance of specific services. ...

Purification and Characterization of Suicin 65, a Novel Class I Type B Lantibiotic Produced by Streptococcus suis.

Science.gov (United States)

Vaillancourt, Katy; LeBel, Geneviève; Frenette, Michel; Fittipaldi, Nahuel; Gottschalk, Marcelo; Grenier, Daniel

2015-01-01

Bacteriocins are antimicrobial peptides of bacterial origin that are considered as a promising alternative to the use of conventional antibiotics. Recently, our laboratory reported the purification and characterization of two lantibiotics, suicin 90-1330 and suicin 3908, produced by the swine pathogen and zoonotic agent Streptococcus suis (serotype 2). In this study, a novel bacteriocin produced by S. suis has been identified and characterized. The producing strain S. suis 65 (serotype 2) was found to belong to the sequence type 28, that includes strains known to be weakly or avirulent in a mouse model. The bacteriocin, whose production was only possible following growth on solid culture medium, was purified to homogeneity by cationic exchange and reversed-phase high-pressure liquid chromatography. The bacteriocin, named suicin 65, was heat, pH and protease resistant. Suicin 65 was active against all S. suis isolates tested, including antibiotic resistant strains. Amino acid sequencing of the purified bacteriocin by Edman degradation revealed the presence of modified amino acids suggesting a lantibiotic. Using the partial sequence obtained, a blast was performed against published genomes of S. suis and allowed to identify a putative lantibiotic locus in the genome of S. suis 89-1591. From this genome, primers were designed and the gene cluster involved in the production of suicin 65 by S. suis 65 was amplified by PCR. Sequence analysis revealed the presence of ten open reading frames, including a duplicate of the structural gene. The structural genes (sssA and sssA') of suicin 65 encodes a 25-amino acid residue leader peptide and a 26-amino acid residue mature peptide yielding an active bacteriocin with a deducted molecular mass of 3,005 Da. Mature suicin 65 showed a high degree of identity with class I type B lantibiotics (globular structure) produced by Streptococcus pyogenes (streptococcin FF22; 84.6%), Streptococcus macedonicus (macedocin ACA-DC 198; 84

Purification and Characterization of Suicin 65, a Novel Class I Type B Lantibiotic Produced by Streptococcus suis.

Directory of Open Access Journals (Sweden)

Katy Vaillancourt

Full Text Available Bacteriocins are antimicrobial peptides of bacterial origin that are considered as a promising alternative to the use of conventional antibiotics. Recently, our laboratory reported the purification and characterization of two lantibiotics, suicin 90-1330 and suicin 3908, produced by the swine pathogen and zoonotic agent Streptococcus suis (serotype 2. In this study, a novel bacteriocin produced by S. suis has been identified and characterized. The producing strain S. suis 65 (serotype 2 was found to belong to the sequence type 28, that includes strains known to be weakly or avirulent in a mouse model. The bacteriocin, whose production was only possible following growth on solid culture medium, was purified to homogeneity by cationic exchange and reversed-phase high-pressure liquid chromatography. The bacteriocin, named suicin 65, was heat, pH and protease resistant. Suicin 65 was active against all S. suis isolates tested, including antibiotic resistant strains. Amino acid sequencing of the purified bacteriocin by Edman degradation revealed the presence of modified amino acids suggesting a lantibiotic. Using the partial sequence obtained, a blast was performed against published genomes of S. suis and allowed to identify a putative lantibiotic locus in the genome of S. suis 89-1591. From this genome, primers were designed and the gene cluster involved in the production of suicin 65 by S. suis 65 was amplified by PCR. Sequence analysis revealed the presence of ten open reading frames, including a duplicate of the structural gene. The structural genes (sssA and sssA' of suicin 65 encodes a 25-amino acid residue leader peptide and a 26-amino acid residue mature peptide yielding an active bacteriocin with a deducted molecular mass of 3,005 Da. Mature suicin 65 showed a high degree of identity with class I type B lantibiotics (globular structure produced by Streptococcus pyogenes (streptococcin FF22; 84.6%, Streptococcus macedonicus (macedocin ACA

Causes of failure to control hypertension in people over 65 years of age

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Alireza Khosravi

2012-03-01

Full Text Available BACKGROUND: Hypertension is a major cause of cardiovascular diseases whose prevalence increases by 10% for every 10 years after 50 years of age. This study aimed to investigate the causes of failure to control blood pressure in people aged over 65 years old. METHODS: This descriptive case-control study was conducted on 200 participants aged over 65 years old who were diagnosed with hypertension through a routine travel check-up for pilgrimage to Mecca in Amin Hospital, Isfahan, Iran during 2003. Following the medical examinations and blood pressure measurements according to the World Health Organization (WHO standards, the participants were divided into two groups of controlled blood pressure (case and uncontrolled blood pressure (control. A questionnaire was filled in for each participant and the data was analyzed using chi-square and student-t tests. RESULTS: The mean age was 70.7 ± 5.2 and 69 ± 4.9 in case and control groups, respectively. Less than half of the participants in the case group took anti-hypertensive medicine, out of which 87.5% were treated by a physician and 12.5% practiced self-therapy. In addition, 25% took their medicine regularly and 55% expressed a lack of motivation as the cause of discontinuing their medication. Furthermore, patients with controlled blood pressure had significantly better knowledge and performance than the case group (P < 0.05. CONCLUSION: The most common causes of failure to control blood pressure were poor knowledge, inappropriate practice in diet, stress, smoking, and irregular intake of medication. Keywords: Hypertension, Cardiovascular Diseases, Antihypertensive Agents, Diet Therapy    

Atomoxetine and Methylphenidate Treatment in Children with ADHD: The Efficacy, Tolerability and Effects on Executive Functions

Science.gov (United States)

Yildiz, Ozlem; Sismanlar, Sahika G.; Memik, Nursu Cakin; Karakaya, Isik; Agaoglu, Belma

2011-01-01

The aim of this study was to compare the safety, efficacy, tolerability, and the effects of atomoxetine and OROS-MPH on executive functions in children with ADHD. This study was an open-label study that only included two medication groups. Children were randomized to open-label atomoxetine or OROS-MPH for 12 weeks. Primary efficacy measures were…

65Zn kinetics as a biomarker of DMH induced colon carcinogenesis

International Nuclear Information System (INIS)

Chadha, Vijayta Dani

2012-01-01

Dietary factors are considered crucial for the prevention of initiating events in the multistep progression of colon carcinoma. There is substantial evidence that zinc may play a pivotal role in host defense against several malignancies, including colon cancer. The present study was conducted to evaluate the kinetics of zinc utilization following experimental colon carcinogenesis in rat model. The rats were segregated into two groups viz., untreated control and DMH treated. Colon carcinogenesis was established through weekly subcutaneous injections of DMH (30mg/Kg body weight) for 16 weeks. Whole body 65 Zn kinetics followed two compartment kinetics, with Tb1 representing the initial fast component of the biological half-life and Tb2, the slower component. The present study revealed a significant depression in the Tb1 and Tb2 components of 65 Zn in DMH treated rats. Further, DMH treatment caused a significant increase in the percent uptake values of 65 Zn in the colon, small intestine, kidney and blood, whereas a significant decrease was observed in the liver. Subcellular distribution revealed a significant increase in 65 Zn uptake in the mitochondrial and microsomal fractions following 16 weeks of DMH supplementation. The present study demonstrated a slow mobilization of zinc during promotion of experimentally induced colon carcinogenesis and provides a physiological basis for the role of zinc in colon tumorigenesis, a paradigm which may have clinical implications in the management of colon cancer. (author)

Enhancement of uranium loading on ion exchange resin from carbonate leachate by lowering pH from 8 to 6.5

International Nuclear Information System (INIS)

Otto, J.B.

1984-01-01

This paper discusses a laboratory study that shows the saturation ion-exchange loading of uranium from carbonate leachate can be doubled by lowering the pH of the leachate from 8 to 6.5. Small column and batch resin loading tests using Dowex 21K ion-exchange resin are described. The leachate contained 3,300 ppm chloride, 2,400 ppm carbonate, and 220 ppm U 3 O 8 , and had a pH of 8. Even at this rather mild salinity the saturation ion-exchange loading was found to be only about 3 to 4 lbm U 3 O 8 /cu ft resin (48 to 64 g/dm 3 ) because of competition with the chloride ion for exchange sites on the anionic resin. Lowering the pH of the leachate to 6.5 by CO 2 gas addition, however, increased loading to about 8 lbm U 3 O 8 /cu ft resin (128 g/dm 3 ). The pH-lowering effect worked especially well at relatively high salt concentration. The same leachate, with its chloride content increased to 12,000 ppm, loaded only 0.5 lbm U 3 O 8 /cu ft resin (8 g/dm 3 ) at pH 8 but loaded 5.5 lbm U 3 O 8 /cu ft resin (88 g/dm 3 ) at pH 6.5

31 CFR 360.55 - Individuals authorized to certify.

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2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Individuals authorized to certify. 360.55 Section 360.55 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... imprint of either the corporate seal of the institution or of the issuing or paying agent's stamp. The...

31 CFR 353.55 - Individuals authorized to certify.

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2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Individuals authorized to certify. 353.55 Section 353.55 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... imprint of either the corporate seal of the institution or of the issuing or paying agent's stamp. The...

7 CFR 319.55-7 - Importations by mail.

Science.gov (United States)

2010-01-01

... foreign mailing point by a special mailing tag directing the package to a Plant Protection and Quarantine... 7 Agriculture 5 2010-01-01 2010-01-01 false Importations by mail. 319.55-7 Section 319.55-7 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION...

7 CFR 319.55-2 - Application for permit.

Science.gov (United States)

2010-01-01

... rice hulls from any country, may be made to the Plant Protection and Quarantine Programs, indicating in... 7 Agriculture 5 2010-01-01 2010-01-01 false Application for permit. 319.55-2 Section 319.55-2 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION...

32 CFR 842.55 - Scope of this subpart.

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2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Scope of this subpart. 842.55 Section 842.55 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE CLAIMS AND LITIGATION... property damage, personal injury, or death caused by military and civilian members of the US Armed Forces...

22 CFR 41.55 - Aliens with extraordinary ability.

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2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Aliens with extraordinary ability. 41.55... IMMIGRATION AND NATIONALITY ACT, AS AMENDED Business and Media Visas § 41.55 Aliens with extraordinary ability. (a) Requirements for O classification. An alien shall be classifiable under the provisions of INA 101...

32 CFR 701.55 - Processing FOIA fee remittances.

Science.gov (United States)

2010-07-01

... 32 National Defense 5 2010-07-01 2010-07-01 false Processing FOIA fee remittances. 701.55 Section... REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND PUBLICATION OF DEPARTMENT OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC FOIA Fees § 701.55 Processing FOIA fee remittances. (a...

Bm65 is essential for the propagation of Bombyx mori nucleopolyhedrovirus.

Science.gov (United States)

Tang, Qi; Li, Guohui; Yao, Qin; Chen, Liang; Feng, Fan; Yuan, Yi; Chen, Keping

2013-01-01

Orf65 (Bm65) of Bombyx mori nucleopolyhedrovirus (BmNPV) is a highly conserved gene that encodes an unknown 104-amino acid protein. In the present study, we have shown the role of Bm65 in the baculovirus life cycle. 5'-RACE analysis showed that the transcription start site of Bm65 was 14 nucleotides upstream of the start codon ATG. The transcription profile of Bm65 was detected from 6 to 72 h postinfection (p. i.) by RT-PCR. A Bm65-knockout bacmid was constructed by homologous recombination to characterize the role of Bm65 in viral life cycle. Fluorescence microscopy showed that Bm65-knockout virus was unable to generate infectious budded virus in BmN cells. Furthermore, quantitative real-time PCR analysis demonstrated that Bm65 deletion did not affect the viral DNA replication. To conclude, Bm65 is essential for the propagation of BmNPV, but is unnecessary for the replication of viral DNA.

Loneliness, Sociodemographic and Mental Health Variables in Spanish Adults over 65 Years Old.

Science.gov (United States)

Ausín, Berta; Muñoz, Manuel; Castellanos, Miguel A

2017-10-11

Loneliness is a risk factor for morbidity as well as mortality. Older people are more vulnerable to feeling alone due to age-associated changes and losses they might experience. This study aimed to analyze sociodemographic, psychosocial, and mental health variables related to loneliness in the elderly. A random sample of 419 people over 65 years old from the Community of Madrid was used. The UCLA Loneliness Scale, the CIDI65+ Diagnostic Interview, and the WHOQOL-BREF Quality of Life Measure were administered. A regression p model was estimated to identify the variables that best predict loneliness associated with old age. Loneliness-associated variables included living alone t(161.41) = 2.07; p social relationships F(4, 405) = 19.50; p anxiety disorder (t(51.11) = 2.19; p loneliness in older people that could be useful in intervention, to minimize harmful conditions that can lead to loneliness in people over 65.

46 CFR 167.65-35 - Use of auto pilot.

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2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Use of auto pilot. 167.65-35 Section 167.65-35 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS PUBLIC NAUTICAL SCHOOL SHIPS Special Operating Requirements § 167.65-35 Use of auto pilot. Except as provided in 33 CFR 164.15, when...

31 CFR 315.55 - Individuals authorized to certify.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Individuals authorized to certify. 315.55 Section 315.55 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... authenticated by a legible imprint either of a corporate stamp of the institution or of the issuing or paying...

Identification of Candida Species Using MP65 Gene and Evaluation of the Candida albicans MP65 Gene Expression in BALB/C Mice.

Science.gov (United States)

Bineshian, Farahnaz; Yadegari, Mohammad Hossien; Sharifi, Zohre; Akbari Eidgahi, Mohammadreza; Nasr, Reza

2015-05-01

Systemic candidiasis is a major public health concern. In particular, in immunocompromised people, such as patients with neutropenia, patients with Acquired Immune Deficiency Syndrome (AIDS) and cancer who are undergoing antiballistic chemotherapy or bone marrow transplants, and people with diabetes. Since the clinical signs and symptoms are nonspecific, early diagnosis is often difficult. The 65-kDa mannoprotein (MP65) gene of Candida albicans is appropriate for detection and identification of systemic candidiasis. This gene encodes a putative b-glucanase mannoprotein of 65 kDa, which plays a major role in the host-fungus relationship, morphogenesis and pathogenicity. The current study aimed to identify different species of Candida (C. albicans, C. glabrata and C. parapsilosis) using the Polymerase Chain Reaction (PCR) technique and also to evaluate C. albicans MP65 gene expression in BALB/C mice. All yeast isolates were identified on cornmeal agar supplemented with tween-80, germ tube formation in serum, and assimilation of carbon sources in the API 20 C AUX yeast identification system. Polymerase Chain Reaction was performed on all samples using species-specific primers for the MP65 65 kDa gene. After RNA extraction, cDNA synthesis was performed by the Maxime RT Pre Mix kit. Candida albicans MP65 gene expression was evaluated by quantitative Real-Time (q Real-Time) and Real-Time (RT) PCR techniques. The 2-ΔΔCT method was used to analyze relative changes in gene expression of MP65. For statistical analysis, nonparametric Wilcoxon test was applied using the SPSS version 16 software. Using biochemical methods, one hundred, six and one isolates of clinical samples were determined as C. albicans, C. glabrata and C. parapsilosis, respectively. Species-specific primers for PCR experiments were applied to clinical specimens, and in all cases a single expected band for C. albicans, C. glabrata and C. parapsilosis was obtained (475, 361 and 124 base pairs, respectively

12 CFR 5.65 - Restrictions on undercapitalized institutions.

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2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Restrictions on undercapitalized institutions. 5.65 Section 5.65 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES... defined in 12 CFR part 6. ...

Guanfacine extended release for children and adolescents with attention-deficit/hyperactivity disorder: efficacy following prior methylphenidate treatment

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Huss M

2016-05-01

Full Text Available Michael Huss,1 Vanja Sikirica,2 Amaia Hervas,3,4 Jeffrey H Newcorn,5 Valerie Harpin,6 Brigitte Robertson71Child and Adolescent Psychiatry, Johannes Gutenberg University Mainz, Mainz, Germany; 2Global Health Economics, Outcomes Research and Epidemiology, Shire, Wayne, PA, USA; 3Child and Adolescent Mental Health Unit, University Hospital Mútua de Terressa, Barcelona, Spain; 4Developmental Disorders Unit (UETD, Hospital San Juan de Dios, Barcelona, Spain; 5Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 6Ryegate Children’s Centre, Sheffield Children’s NHS Foundation Trust, Sheffield, UK; 7Global Clinical Development, Shire, Wayne, PA, USAAbstract: Guanfacine extended release (GXR and atomoxetine (ATX are nonstimulant treatments for attention-deficit/hyperactivity disorder (ADHD. As nonstimulant treatments are often used after stimulants in ADHD, GXR was assessed relative to prior stimulant treatment in a randomized controlled trial (RCT, in which ATX was included as a reference arm, and in the open-label phase of a randomized-withdrawal study (RWS. Participants were 6–17 years old with ADHD Rating Scale version IV (ADHD-RS-IV scores ≥32 and Clinical Global Impressions – Severity scores ≥4. RCT participants received dose-optimized GXR (1–7 mg/day, ATX (10–100 mg/day, or placebo for 10–13 weeks. RWS participants received dose-optimized GXR (1–7 mg/day for 13 weeks. Participants’ last stimulant medication prior to enrolment, and reasons for stopping this medication, were collected at baseline. Change from baseline ADHD-RS-IV score and the proportion of responders were assessed by prior stimulant exposure. Of 163 RCT and 296 RWS participants who had previously received stimulant treatment, 142 and 224, respectively, had received methylphenidate (MPH; due to the low number of participants and the heterogeneity of non-MPH treatments, we only report data for prior MPH treatment. The most

Methylphenidate use and poly-substance use among undergraduate students attending a South African university

Directory of Open Access Journals (Sweden)

Francois Steyn

2016-03-01

Full Text Available Background: Methylphenidate hydrochloride (MPH is used in the treatment of attention deficit hyperactivity disorder (ADHD. The non-medical use of MPH by learners and students has been reported by numerous studies from abroad. The practice stems from beliefs about the benefits of MPH in achieving academic success. Little is known about the use of MPH in South African student populations. Objectives: The study set out to determine (1 the extent and dynamics associated with MPH use and (2 poly-substance use among undergraduate students attending a South African university. Methods: 818 students took part in a written, group-administered survey. Data analysis resulted in descriptive results regarding MPH use and tests of association identified differences in MPH and poly-substance use among respondents. Results: One in six respondents (17.2% has used MPH in the past, although only 2.9% have been diagnosed with ADHD. Nearly a third (31.7% of users obtained MPH products illegally. The majority (69.1% used MPH only during periods of academic stress. A significant association ( p < 0.001 was found between MPH use and the frequency of using alcohol, tobacco, cannabis, hard drugs (e.g. cocaine and prescription medication. Conclusion: MPH use among students appears similar to experiences abroad, especially in the absence of clinical diagnosis for ADHD. Institutions of higher education should inform parents and students about the health risks associated with the illicit use of MPH. Prescribers and dispensers of MPH products should pay close attention to practices of stockpiling medication and poly-substance use among students who use MPH.

Age-dependent variations of zinc-65 metabolism in LACA mice

International Nuclear Information System (INIS)

He Liusheng; Yan Xiaoshan; Wu Dechang

1991-01-01

Mice were gavaged with zinc-65 solution, 8.6-19.3 kBq per mouse, and the whole-body retention and organ content of zinc-65 measured at diffe-rent times afterwards. The age-dependence of the fractional absorption of zinc-65 from the gastrointestinal tract (f 1 ) endogenous faecal excretion fraction of zinc-65 (EFEF), tissue distribution and whole-body retention were determined. f 1 values obtained were 0.86 ±0.15, 0.64±0.11, 0.52±0.07 and 0.39±0.02 in suckling, adolescent, young adult and older mice, respectively. The EFEF values determined were 0.083±0.008, 0.099±0.004, 0.122±0.018 and 0.144±0.005 of intraperitoneally injected zinc-65 was in suckling, adolescent, young adult and older mice at administration. Zinc-65 mainly distributed in the liver, muscle, lung, kidney and bone. In some tissues, there was an inverse relationship between relative content of gavaged zinc-65 and animal's age at administration. The whole-body biological half-lives of zinc-65 increased with animal age. (author)

Raul Meele meeldivad 65

Index Scriptorium Estoniae

2006-01-01

2. märtsil tähistab oma 65. sünnipäeva kunstnik Raul Meel. R. Meel kirjutas-joonistas 2005. a. kaks raamatut. Seoses juubeliga toimub tema loomingut käsitlev konverents Shotimaal Dundee ülikoolis. USA New Jersey Rutgers'i ülikooli juures kirjutatakse Meele-keskselt kaht doktoritööd

Effect of browned and unbrowned corn products intrinsically labeled with 65Zn on absorption of 65Zn in humans

International Nuclear Information System (INIS)

Lykken, G.I.; Mahalko, J.; Johnson, P.E.; Milne, D.; Sandstead, H.H.; Garcia, W.J.; Dintzis, F.R.; Inglett, G.E.

1986-01-01

Experimental browned and unbrowned corn products were formulated and processed from unenriched, degermed yellow corngrits. The browned product (cornflakes) contained more insoluble dietary fiber and bound more zinc (in vitro) than the unbrowned product (corngrits). During processing some of the cornflakes and corngrits were combined with a small amount of yellow corn endospermhull intrinsically labeled with 65 Zn. The intrinsically labeled corn products were fed, in a crossover design, as components of two breakfasts to six normal, unconfined volunteers. Each volunteer absorbed more 65 Zn from the corngrits than from the cornflakes. The reduced 65 Zn absorption from cornflakes was attributed to heating and toasting reaction products, possibly Maillard, which bound zinc and consequently made the zinc less available for absorption

21 CFR 821.55 - Confidentiality.

Science.gov (United States)

2010-04-01

... permission to release, the patient's name, address, telephone number, and social security number, or other... MEDICAL DEVICE TRACKING REQUIREMENTS Records and Inspections § 821.55 Confidentiality. (a) Any patient... identify patient or research subjects shall not be available for public disclosure except as provided in...

Fundus albipunctatus associated with compound heterozygous mutations in RPE65

DEFF Research Database (Denmark)

Schatz, Patrik; Preising, Markus; Lorenz, Birgit

2011-01-01

To describe a family with an 18-year-old woman with fundus albipunctatus and compound heterozygous mutations in RPE65 whose unaffected parents and 1 female sibling harbored single heterozygous RPE65 mutations.......To describe a family with an 18-year-old woman with fundus albipunctatus and compound heterozygous mutations in RPE65 whose unaffected parents and 1 female sibling harbored single heterozygous RPE65 mutations....

Ethylphenidate as a selective dopaminergic agonist and methylphenidate-ethanol transesterification biomarker.

Science.gov (United States)

Patrick, Kennerly S; Corbin, Timothy R; Murphy, Cristina E

2014-12-01

We review the pharmaceutical science of ethylphenidate (EPH) in the contexts of drug discovery, drug interactions, biomarker for dl-methylphenidate (MPH)-ethanol exposure, potentiation of dl-MPH abuse liability, contemporary "designer drug," pertinence to the newer transdermal and chiral switch MPH formulations, as well as problematic internal standard. d-EPH selectively targets the dopamine transporter, whereas d-MPH exhibits equipotent actions at dopamine and norepinephrine transporters. This selectivity carries implications for the advancement of tailored attention-deficit/hyperactivity disorder (ADHD) pharmacotherapy in the era of genome-based diagnostics. Abuse of dl-MPH often involves ethanol coabuse. Carboxylesterase 1 enantioselectively transesterifies l-MPH with ethanol to yield l-EPH accompanied by significantly increased early exposure to d-MPH and rapid potentiation of euphoria. The pharmacokinetic component of this drug interaction can largely be avoided using dexmethylphenidate (dexMPH). This notwithstanding, maximal potentiated euphoria occurs following dexMPH-ethanol. C57BL/6 mice model dl-MPH-ethanol interactions: an otherwise depressive dose of ethanol synergistically increases dl-MPH stimulation; a substimulatory dose of dl-MPH potentiates a low, stimulatory dose of ethanol; ethanol elevates blood, brain, and urinary d-MPH concentrations while forming l-EPH. Integration of EPH preclinical neuropharmacology with clinical studies of MPH-ethanol interactions provides a translational approach toward advancement of ADHD personalized medicine and management of comorbid alcohol use disorder. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

Is the AIMS65 score useful in predicting outcomes in peptic ulcer bleeding?

Science.gov (United States)

Jung, Sung Hoon; Oh, Jung Hwan; Lee, Hye Yeon; Jeong, Joon Won; Go, Se Eun; You, Chan Ran; Jeon, Eun Jung; Choi, Sang Wook

2014-02-21

To evaluate the applicability of AIMS65 scores in predicting outcomes of peptic ulcer bleeding. This was a retrospective study in a single center between January 2006 and December 2011. We enrolled 522 patients with upper gastrointestinal haemorrhage who visited the emergency room. High-risk patients were regarded as those who had re-bleeding within 30 d from the first endoscopy as well as those who died within 30 d of visiting the Emergency room. A total of 149 patients with peptic ulcer bleeding were analysed, and the AIMS65 score was used to retrospectively predict the high-risk patients. A total of 149 patients with peptic ulcer bleeding were analysed. The poor outcome group comprised 28 patients [male: 23 (82.1%) vs female: 5 (10.7%)] while the good outcome group included 121 patients [male: 93 (76.9%) vs female: 28 (23.1%)]. The mean age in each group was not significantly different. The mean serum albumin levels in the poor outcome group were slightly lower than those in the good outcome group (P = 0.072). For the prediction of poor outcome, the AIMS65 score had a sensitivity of 35.5% (95%CI: 27.0-44.8) and a specificity of 82.1% (95%CI: 63.1-93.9) at a score of 0. The AIMS65 score was insufficient for predicting outcomes in peptic ulcer bleeding (area under curve = 0.571; 95%CI: 0.49-0.65). The AIMS65 score may therefore not be suitable for predicting clinical outcomes in peptic ulcer bleeding. Low albumin levels may be a risk factor associated with high mortality in peptic ulcer bleeding.

Vertical distribution of 55Fe in the ocean

International Nuclear Information System (INIS)

Jennings, C.D.

1976-01-01

The highest concentrations of 55 Fe in the ocean are found in the epipelagic and mesopelagic zones with only low concentrations occurring in benthic animals and sediments. 55 Fe in the sediment appears in a very thin surface layer in the equatorial Pacific so that great care in sampling must be exercised to ensure accurate measurement

Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome.

Science.gov (United States)

Greber, Basil J; Bieri, Philipp; Leibundgut, Marc; Leitner, Alexander; Aebersold, Ruedi; Boehringer, Daniel; Ban, Nenad

2015-04-17

Mammalian mitochondrial ribosomes (mitoribosomes) synthesize mitochondrially encoded membrane proteins that are critical for mitochondrial function. Here we present the complete atomic structure of the porcine 55S mitoribosome at 3.8 angstrom resolution by cryo-electron microscopy and chemical cross-linking/mass spectrometry. The structure of the 28S subunit in the complex was resolved at 3.6 angstrom resolution by focused alignment, which allowed building of a detailed atomic structure including all of its 15 mitoribosomal-specific proteins. The structure reveals the intersubunit contacts in the 55S mitoribosome, the molecular architecture of the mitoribosomal messenger RNA (mRNA) binding channel and its interaction with transfer RNAs, and provides insight into the highly specialized mechanism of mRNA recruitment to the 28S subunit. Furthermore, the structure contributes to a mechanistic understanding of aminoglycoside ototoxicity. Copyright © 2015, American Association for the Advancement of Science.

29 CFR 1918.55 - Cranes (See also § 1918.11).

Science.gov (United States)

2010-07-01

... 29 Labor 7 2010-07-01 2010-07-01 false Cranes (See also § 1918.11). 1918.55 Section 1918.55 Labor... (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Vessel's Cargo Handling Gear § 1918.55 Cranes (See also § 1918.11). The following requirements shall apply to the use of cranes forming part of a vessel's...

HWY 55 Burger, fries & shakes: Project management & marketing theory

OpenAIRE

Nguyen, David; Nelbom, Mathies

2015-01-01

Hwy 55 is an American fast-dining restaurant that aims to expand into the Danish market. Their ambition is to open 30-35 restaurant across the country over the next ten years. Jens-Christian Due, responsible for Hwy 55 expansion into the Danish market, proclaims that there has been lacking a restaurant located between McDonalds and Jensen’s Boefhus and that Hwy 55 is the golden mean. A statement this project seeks to identify and elaborate by providing a clear overview of the company through ...

BIPM comparison BIPM.RI(II)-K1.Zn-65 of activity measurements of the radionuclide 65Zn for the BARC (India) with linked results for the CCRI(II)-K2.Zn-65 comparison

International Nuclear Information System (INIS)

Michotte, C.; Ratel, G.; Courte, S.; Joseph, L.

2015-01-01

A new participation in the BIPM.RI(II)-K1.Zn-65 comparison has been added to the previous results. A link has been made to the CCRI(II)-K2.Zn-65 comparison held in 2003 through the measurement of all ampoules of the K2 comparison in the International Reference System (SIR) at the BIPM before despatch to the participants. This has produced a revised value for the key comparison reference value (KCRV), calculated using the power-moderated weighted mean. Six NMIs used the K2 comparison to update their degree of equivalence. The degrees of equivalence between each equivalent activity measured in the International Reference System (SIR) and the KCRV have been calculated and the results are given in the form of a table for the remaining two NMIs in the BIPM.RI(II)-K1.Zn-65 comparison and the 17 other participants in the CCRI(II)-K2.Zn-65 comparison. A graphical presentation is also given. (authors)

Remission in children and adolescents diagnosed with attention-deficit/hyperactivity disorder via an effective and tolerable titration scheme for osmotic release oral system methylphenidate.

Science.gov (United States)

Chou, Wen-Jiun; Chen, Shin-Jaw; Chen, Ying-Sheue; Liang, Hsin-Yi; Lin, Chih-Chien; Tang, Ching-Shu; Huang, Yu-Shu; Yeh, Chin-Bin; Chou, Miao-Chun; Lin, Dai-Yueh; Hou, Po-Hsun; Wu, Yu-Yu; Liu, Hung-Jen; Huang, Ya-Fen; Hwang, Kai-Ling; Chan, Chin-Hong; Pan, Chia-Ho; Chang, Hsueh-Ling; Huang, Chi-Fen; Hsu, Ju-Wei

2012-06-01

The purpose of this study was to identify the optimal dose of osmotic release oral system methylphenidate (OROS-MPH) using a dosage forced-titration scheme to achieve symptomatic remission in children with attention- deficit/hyperactivity disorder (ADHD). We also evaluated the efficacy and safety of, and patient and parent satisfaction with, the change in therapy from immediate-release methylphenidate (IR-MPH) to OROS-MPH over 10 weeks. We recruited 521 children and adolescents aged 6-18 years with an American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV) diagnosis of ADHD, who had received IR-MPH treatments (titration phase of OROS-MPH to achieve symptomatic remission (defined as a score of 0 or 1 for each of the first 18 ADHD items in the Chinese version of the Swanson, Nolan, and Pelham, Version IV [SNAP-IV]), followed by a 4-week maintenance phase. The global ADHD severity and drug side effects of the participants were evaluated. Parents completed the ratings scales for the ADHD-related symptoms. Patient and parent satisfaction for the OROS-MPH treatment was also assessed. Among the 439 participants with ADHD who completed the trial, 290 participants (66.1%) achieved symptomatic remission. The mean dose of OROS-MPH among participants in remission was 36.7 mg (1.08 mg/kg) per day. Increased efficacy, superior satisfaction, and safety equivalent to that of IR-MPH were demonstrated in intra-individual comparisons from the baseline to the end of study. Determinants for remission included less severe ADHD symptoms (SNAP-IV score history of ADHD, and an appropriate dosage of medication according to the patient's weight. The findings suggest remission as a treatment goal for ADHD therapy by providing an optimal dosage of medication for children and adolescents with ADHD through using an effective and tolerable forced-titration scheme.

Comparative efficacy and safety of methylphenidate and atomoxetine for attention-deficit hyperactivity disorder in children and adolescents: Meta-analysis based on head-to-head trials.

Science.gov (United States)

Liu, Qiang; Zhang, Hong; Fang, Qingqing; Qin, Lili

2017-11-01

Comparative efficacy and safety are important issues for appropriate drug selection for attention-deficit hyperactivity disorder (ADHD) treatment. Therefore we conducted a meta-analysis, where we compared atomoxetine (ATX) and methylphenidate (MPH) for ADHD treatment in children and adolescents. Literature retrieval was conducted in relevant databases from their inception to April 2016 to select head-to-head trials that compared ATX and MPH in children and adolescents. Outcomes like response rate, ADHD Rating Scale (ADHD-RS) score, and adverse events were compared between ATX and MPH treatments. The standardized mean difference (SMD) and risk ratio (RR) with their corresponding 95% confidence intervals (CIs) were used as the effect size for continuous data or dichotomous data, respectively. Eleven eligible randomized-controlled trials were included, and two of them were double-blind, while the remaining were open-label. Compared to ATX, MPH showed a higher response rate (RR = 1.14, 95% CI [1. 09, 1.20]), decreased inattention (SMD = -0.13, 95% CI [-0.25, -0.01]) and lower risk of adverse events (drowsiness: RR = 0.17, 95% CI [0.11, 0.26; nausea: RR = 0.49; 95% CI [0.29, 0.85; vomiting: RR = 0.41, 95% CI [0.27, 0.63]). However, MPH presented a higher risk of insomnia than ATX (RR = 2.27, 95% CI [1.63, 3.15], p < .01). Results of the meta-analysis add additional evidence of the effectiveness of both ATX and MPH and suggest that MPH should be a first treatment option in most patients with ADHD.

14 CFR 33.65 - Surge and stall characteristics.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Surge and stall characteristics. 33.65 Section 33.65 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... stall characteristics. When the engine is operated in accordance with operating instructions required by...

Production and quality control of 65Zn radionuclide

International Nuclear Information System (INIS)

Rowshanfarzad, P.; Jalilian, R.; Sabet, M.

2005-01-01

Zinc-65 was produced in the Nuclear Research Center for Agriculture and Medicine (NRCAM) by the bombardment of natural copper targets with 30 MeV protons via the 65 Cu(p,n) 65 Zn nuclear reaction. Natural copper was used instead of enriched 65 Cu because of the quick decay of undesired radioisotopes. It was also more desirable for cost effectiveness. Cross-section calculations were performed by ALICE nuclear code and the results were compared with the experimental data given in the literature, which showed good agreement. A 160 μm copper layer target was bombarded with a 150 μA current of 30 MeV protons for 20 min, which resulted in 170 MBq activity of 65 Zn product. The yield was 3.4 MBq/μAh. The concentration of the product was 6.8 MBq/ml. Radiochemical separation was carried out by anion exchange chromatography with the yield of about 98%. Quality control of the final product showed a radionuclide purity of more than 98% and no traces of possible impurities (copper) were detected by a colorimetric method with a 1 ppm detection limit using dithizone as the reagent. The materials used for targetry and chemical separation were quite cost-effective. (author)

Strain actuated aeroelastic control

Science.gov (United States)

Lazarus, Kenneth B.

1992-01-01

Viewgraphs on strain actuated aeroelastic control are presented. Topics covered include: structural and aerodynamic modeling; control law design methodology; system block diagram; adaptive wing test article; bench-top experiments; bench-top disturbance rejection: open and closed loop response; bench-top disturbance rejection: state cost versus control cost; wind tunnel experiments; wind tunnel gust alleviation: open and closed loop response at 60 mph; wind tunnel gust alleviation: state cost versus control cost at 60 mph; wind tunnel command following: open and closed loop error at 60 mph; wind tunnel flutter suppression: open loop flutter speed; and wind tunnel flutter suppression: closed loop state cost curves.

Predicting methylphenidate response in attention deficit hyperactivity disorder: a preliminary study.

Science.gov (United States)

Johnston, Blair A; Coghill, David; Matthews, Keith; Steele, J Douglas

2015-01-01

Methylphenidate (MPH) is established as the main pharmacological treatment for patients with attention deficit hyperactivity disorder (ADHD). Whilst MPH is generally a highly effective treatment, not all patients respond, and some experience adverse reactions. Currently, there is no reliable method to predict how patients will respond, other than by exposure to a trial of medication. In this preliminary study, we sought to investigate whether an accurate predictor of clinical response to methylphenidate could be developed for individual patients, using sociodemographic, clinical and neuropsychological measures. Of the 43 boys with ADHD included in this proof-of-concept study, 30 were classed as responders and 13 as non-responders to MPH, with no significant differences in age nor verbal intelligence quotient (IQ) between the groups. Here we report the application of a multivariate analysis approach to the prediction of clinical response to MPH, which achieved an accuracy of 77% (p = 0.005). The most important variables to the classifier were performance on a 'go/no go' task and comorbid conduct disorder. This preliminary study suggested that further investigation is merited. Achieving a highly significant accuracy of 77% for the prediction of MPH response is an encouraging step towards finding a reliable and clinically useful method that could minimise the number of children needlessly being exposed to MPH. © The Author(s) 2014.

Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task

International Nuclear Information System (INIS)

Goldstein, R.Z.; Woicik, P.A.; Maloney, T.; Tomasi, D.; Alia-Klein, N.; Shan, J.; Honorario, J.; Samaras, D.; Wang, R.; Telang, F.; Wang, G.-J.; Volkow, N.D.

2010-01-01

Anterior cingulate cortex (ACC) hypoactivations during cognitive demand are a hallmark deficit in drug addiction. Methylphenidate (MPH) normalizes cortical function, enhancing task salience and improving associated cognitive abilities, in other frontal lobe pathologies; however, in clinical trials, MPH did not improve treatment outcome in cocaine addiction. We hypothesized that oral MPH will attenuate ACC hypoactivations and improve associated performance during a salient cognitive task in individuals with cocaine-use disorders (CUD). In the current functional MRI study, we used a rewarded drug cue-reactivity task previously shown to be associated with hypoactivations in both major ACC subdivisions (implicated in default brain function) in CUD compared with healthy controls. The task was performed by 13 CUD and 14 matched healthy controls on 2 d: after ingesting a single dose of oral MPH (20 mg) or placebo (lactose) in a counterbalanced fashion. Results show that oral MPH increased responses to this salient cognitive task in both major ACC subdivisions (including the caudal-dorsal ACC and rostroventromedial ACC extending to the medial orbitofrontal cortex) in the CUD. These functional MRI results were associated with reduced errors of commission (a common impulsivity measure) and improved task accuracy, especially during the drug (vs. neutral) cue-reactivity condition in all subjects. The clinical application of such MPH-induced brain-behavior enhancements remains to be tested.

Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task

Energy Technology Data Exchange (ETDEWEB)

Goldstein, R.Z.; Goldstein, R.Z.; Woicik, P.A.; Maloney, T.; Tomasi, D.; Alia-Klein, N.; Shan, J.; Honorario, J.; Samaras, d.; Wang, R.; Telang, F.; Wang, G.-J.; Volkow, N.D.

2010-09-21

Anterior cingulate cortex (ACC) hypoactivations during cognitive demand are a hallmark deficit in drug addiction. Methylphenidate (MPH) normalizes cortical function, enhancing task salience and improving associated cognitive abilities, in other frontal lobe pathologies; however, in clinical trials, MPH did not improve treatment outcome in cocaine addiction. We hypothesized that oral MPH will attenuate ACC hypoactivations and improve associated performance during a salient cognitive task in individuals with cocaine-use disorders (CUD). In the current functional MRI study, we used a rewarded drug cue-reactivity task previously shown to be associated with hypoactivations in both major ACC subdivisions (implicated in default brain function) in CUD compared with healthy controls. The task was performed by 13 CUD and 14 matched healthy controls on 2 d: after ingesting a single dose of oral MPH (20 mg) or placebo (lactose) in a counterbalanced fashion. Results show that oral MPH increased responses to this salient cognitive task in both major ACC subdivisions (including the caudal-dorsal ACC and rostroventromedial ACC extending to the medial orbitofrontal cortex) in the CUD. These functional MRI results were associated with reduced errors of commission (a common impulsivity measure) and improved task accuracy, especially during the drug (vs. neutral) cue-reactivity condition in all subjects. The clinical application of such MPH-induced brain-behavior enhancements remains to be tested.

Influence of Methylphenidate on the Frequency of Stuttering: A Randomized Controlled Trial.

Science.gov (United States)

Rabaeys, Henk; Bijleveld, Henny-Annie; Devroey, Dirk

2015-10-01

Recently, a case report described a decrease in frequency of stuttering after intake of methylphenidate (MPH). This study was undertaken to investigate if this effect could again be reproduced in a population of young healthy male adult persons with developmental stuttering. A double-blind randomized crossover trial, with a 2-week washout period, including 15 Dutch-speaking young healthy persons with developmental stuttering, assessed the effects of a single dose of 20 mg MPH compared with placebo on stuttering. Dependent and 1-sample t tests were used to detect significant differences. The end point was the number of stutter moments and self-perceived improvement. MPH yielded a significant decrease in the number of stutter moments when reading and speaking (P = 0.002), which was not the case with placebo (P = 0.090). There was a significant improvement from baseline after intake of MPH as compared with placebo (P = 0.003). Self-perceived improvement with MPH was not significantly better as compared with placebo (P = 0.28). This study showed that the participants had an objective statistically significant decrease in the frequency of stuttering with MPH, and this was not the case with placebo. This was also the case for a reduction in stutter moments when reading out loud and speaking spontaneously. However, this result was not subjectively perceived by the participants. © The Author(s) 2015.

45 CFR 302.65 - Withholding of unemployment compensation.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false Withholding of unemployment compensation. 302.65... HUMAN SERVICES STATE PLAN REQUIREMENTS § 302.65 Withholding of unemployment compensation. The State plan... State agency charged with the administration of the State unemployment compensation laws in accordance...

16 CFR 5.65 - Review of initial decision.

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Review of initial decision. 5.65 Section 5.65 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE... initial decision. Appeals from the initial decision of the Administrative Law Judge or review by the...

28 CFR 65.41 - Review of State applications.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Review of State applications. 65.41 Section 65.41 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) EMERGENCY FEDERAL LAW ENFORCEMENT.... The Act provides the basis for review and approval or disapproval of state applications. Federal law...

45 CFR 98.65 - Audits and financial reporting.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Audits and financial reporting. 98.65 Section 98... DEVELOPMENT FUND Financial Management § 98.65 Audits and financial reporting. (a) Each Lead Agency shall have... independent standards. (g) The Secretary shall require financial reports as necessary. ...

32 CFR 636.22 - Speed regulations.

Science.gov (United States)

2010-07-01

...). (d) The following special speed limits apply: (1) When passing troop formations, 10 miles per hour... vehicles and will obey the following off-road driving speeds: Day Driving: Trails, 16 MPH Cross County, 6 MPH Night Driving: Trails, 5 MPH (with headlights) Cross Country, 5 MPH Night Driving: Trails, 4 MPH...

27 CFR 6.65 - General.

Science.gov (United States)

2010-04-01

... TREASURY LIQUORS âTIED-HOUSEâ Unlawful Inducements Extension of Credit § 6.65 General. Extension of credit by an industry member to a retailer for a period of time in excess of 30 days from the date of...

THE YOUNG OPEN CLUSTER BERKELEY 55

Energy Technology Data Exchange (ETDEWEB)

Negueruela, Ignacio; Marco, Amparo, E-mail: ignacio.negueruela@ua.es, E-mail: amparo.marco@ua.es [Departamento de Fisica, Ingenieria de Sistemas y Teoria de la Senal, Universidad de Alicante, Apdo. 99, E-03080 Alicante (Spain)

2012-02-15

We present UBV photometry of the highly reddened and poorly studied open cluster Berkeley 55, revealing an important population of B-type stars and several evolved stars of high luminosity. Intermediate-resolution far-red spectra of several candidate members confirm the presence of one F-type supergiant and six late supergiants or bright giants. The brightest blue stars are mid-B giants. Spectroscopic and photometric analyses indicate an age 50 {+-} 10 Myr. The cluster is located at a distance d Almost-Equal-To 4 kpc, consistent with other tracers of the Perseus Arm in this direction. Berkeley 55 is thus a moderately young open cluster with a sizable population of candidate red (super)giant members, which can provide valuable information about the evolution of intermediate-mass stars.

7 CFR 989.65 - Free and reserve tonnage.

Science.gov (United States)

2010-01-01

... use, may be disposed of by him in any marketing channel, subject to the applicable provisions of this... 7 Agriculture 8 2010-01-01 2010-01-01 false Free and reserve tonnage. 989.65 Section 989.65 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing...

Bioassay techniques for 55Fe in urine samples

International Nuclear Information System (INIS)

Cregan, S.P.; Leon, J.W.; Linauskas, S.H.

1993-11-01

Solvent extraction, ion chromatography and several rapid screening methods were developed and evaluated for 55 Fe bioassay applications. Isopropyl ether and TNOA column extractions had radiochemical recoveries exceeding 90%. These were very reproducible with a coefficient of variation less than 5%. Screening techniques investigated included direct counting of ashed urine solids, and Fe(OH) 3 . precipitated from urine. The sensitivities (2-50 Bq/d urine) of the screening methods were usually limited by the effective urine volume that could be counted in a liquid scintillation counter. The reference isopropyl ether and chromatography methods could easily achieve sensitivities well below the 1 Bq/d urine output target. (author). 49 refs., 3 tabs., 5 figs

40 CFR 262.55 - Exception reports.

Science.gov (United States)

2010-07-01

...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Exports of Hazardous Waste § 262.55 Exception reports... Protection Agency, 1200 Pennsylvania Avenue, NW., Washington, DC 20460, if any of the following occurs: ...

Mena–GRASP65 interaction couples actin polymerization to Golgi ribbon linking

Science.gov (United States)

Tang, Danming; Zhang, Xiaoyan; Huang, Shijiao; Yuan, Hebao; Li, Jie; Wang, Yanzhuang

2016-01-01

In mammalian cells, the Golgi reassembly stacking protein 65 (GRASP65) has been implicated in both Golgi stacking and ribbon linking by forming trans-oligomers through the N-terminal GRASP domain. Because the GRASP domain is globular and relatively small, but the gaps between stacks are large and heterogeneous, it remains puzzling how GRASP65 physically links Golgi stacks into a ribbon. To explore the possibility that other proteins may help GRASP65 in ribbon linking, we used biochemical methods and identified the actin elongation factor Mena as a novel GRASP65-binding protein. Mena is recruited onto the Golgi membranes through interaction with GRASP65. Depleting Mena or disrupting actin polymerization resulted in Golgi fragmentation. In cells, Mena and actin were required for Golgi ribbon formation after nocodazole washout; in vitro, Mena and microfilaments enhanced GRASP65 oligomerization and Golgi membrane fusion. Thus Mena interacts with GRASP65 to promote local actin polymerization, which facilitates Golgi ribbon linking. PMID:26538023

A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus

Directory of Open Access Journals (Sweden)

Crumpacker Clyde S

2011-01-01

Full Text Available Abstract Background The major hurdle in the treatment of Human Immunodeficiency virus type 1 (HIV-1 includes the development of drug resistance-associated mutations in the target regions of the virus. Since reverse transcriptase (RT is essential for HIV-1 replication, several nucleoside analogues have been developed to target RT of the virus. Clinical studies have shown that mutations at RT codon 65 and 74 which are located in β3-β4 linkage group of finger sub-domain of RT are selected during treatment with several RT inhibitors, including didanosine, deoxycytidine, abacavir and tenofovir. Interestingly, the co-selection of K65R and L74V is rare in clinical settings. We have previously shown that K65R and L74V are incompatible and a R→K reversion occurs at codon 65 during replication of the virus. Analysis of the HIV resistance database has revealed that similar to K65R+L74V, the double mutant K65R+L74I is also rare. We sought to compare the impact of L→V versus L→I change at codon 74 in the background of K65R mutation, on the replication of doubly mutant viruses. Methods Proviral clones containing K65R, L74V, L74I, K65R+L74V and K65R+L74I RT mutations were created in pNL4-3 backbone and viruses were produced in 293T cells. Replication efficiencies of all the viruses were compared in peripheral blood mononuclear (PBM cells in the absence of selection pressure. Replication capacity (RC of mutant viruses in relation to wild type was calculated on the basis of antigen p24 production and RT activity, and paired analysis by student t-test was performed among RCs of doubly mutant viruses. Reversion at RT codons 65 and 74 was monitored during replication in PBM cells. In vitro processivity of mutant RTs was measured to analyze the impact of amino acid changes at RT codon 74. Results Replication kinetics plot showed that all of the mutant viruses were attenuated as compared to wild type (WT virus. Although attenuated in comparison to WT virus

14 CFR 65.80 - Certificated aviation maintenance technician school students.

Science.gov (United States)

2010-01-01

... students has made satisfactory progress at the school and is prepared to take the oral and practical tests... technician school students. 65.80 Section 65.80 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 65.80 Certificated aviation maintenance technician school students. Whenever an aviation maintenance...

Transdermal and oral dl-methylphenidate-ethanol interactions in C57BL/6J mice: transesterification to ethylphenidate and elevation of d-methylphenidate concentrations.

Science.gov (United States)

Bell, Guinevere H; Novak, Andrew J; Griffin, William C; Patrick, Kennerly S

2011-07-01

We tested the hypothesis that C57BL/6J mice will model human metabolic interactions between dl-methylphenidate (MPH) and ethanol, placing an emphasis on the MPH transdermal system (MTS). Specifically, we asked: (1) will ethanol increase d-MPH biological concentrations, (2) will MTS facilitate the systemic bioavailability of l-MPH, and (3) will l-MPH enantioselectively interact with ethanol to yield l-ethylphenidate (l-EPH)? Mice were dosed with MTS (¼ of a 12.5 cm(2) patch on shaved skin) or a comparable oral dl-MPH dose (7.5 mg/kg), with or without ethanol (3.0 g/kg), and then placed in metabolic cages for 3 h. MPH and EPH isomer concentrations in blood, brain, and urine were analyzed by gas chromatographic-mass spectrometry monitoring of N-(S)-prolylpiperidyl fragments. As in humans, MTS greatly facilitated the absorption of l-MPH in this mouse strain. Similarly, ethanol led to the enantioselective formation of l-EPH and to an elevation in d-MPH concentrations with both MTS and oral MPH. Although only guarded comparisons between MTS and oral MPH can be made due to route-dependent drug absorption rate differences, MTS was associated with significant MPH-ethanol interactions. Ethanol-mediated increases in circulating concentrations of d-MPH carry toxicological and abuse liability implications should this animal model hold for ethanol-consuming attention-deficit hyperactivity disorder patients or coabusers. Copyright © 2011 Wiley-Liss, Inc. and the American Pharmacists Association

Pokemon reduces Bcl-2 expression through NF-κ Bp65: A possible mechanism of hepatocellular carcinoma.

Science.gov (United States)

Zhao, Xinkai; Ning, Qiaoming; Sun, Xiaoning; Tian, De'an

2011-06-01

To investigate the relationship among Pokemon, NF-κ B p65 and Bcl-2 in hepatoma cells. HCC cell HepG2, SMMC7721 and human fetal liver cell line LO2 cells were used, and expression of Pokemon, NF-κ B p65 and Bcl-2 in three cells were detected by real-time PCR and western blot. Then siRNA of Pokemon was applied to inhibit the expression of Pokemon and NF-κ B p65 and apoptotic rate was determined by flow cytometric analysis. Expressions of Pokemon, NF-κ B p65 and Bcl-2 in human hepatoma cell HepG2, SMMC7721 expression were significantly higher than those in human embryonic stem cells LO2. siRNA of Pokemon inhibited the expression of Pokemon, NF-κ B p65 and Bcl-2 in liver cancer cells, and significantly increased apoptosis of liver cells. While siRNA of NF-κ B p65 inhibited the expression of NF-κ B p65 and Bcl-2, but Pokemon expression in hepatoma cells had no significant change. The proto-oncogene Pokemon can inhibit P14ARF by specific transcription regulation of cell cycle and can induce tumors. In addition, Pokemon can regulate NF-κ B p65 through the expression of apoptosis repressor, and promote the development of liver cancer. It suggests signal network in the liver include the regulation of new non-classical NF-κ B regulatory pathway. Copyright © 2011 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

12 CFR 263.65 - Civil penalty inflation adjustments.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Civil penalty inflation adjustments. 263.65... Money Penalties § 263.65 Civil penalty inflation adjustments. (a) Inflation adjustments. In accordance with the Federal Civil Penalties Inflation Adjustment Act of 1990 (28 U.S.C. 2461 note), the Board has...

7 CFR 201.65 - Noxious weed seeds in interstate commerce.

Science.gov (United States)

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Noxious weed seeds in interstate commerce. 201.65 Section 201.65 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... ACT FEDERAL SEED ACT REGULATIONS Tolerances § 201.65 Noxious weed seeds in interstate commerce...

[Reactogenicity of the simultaneous administration of influenza and pneumococcal vaccines in adults over 55 years of age].

Science.gov (United States)

Ayala-Montiel, Octavio; Mascareñas de los Santos, César; García-Hernández, Delfino; Rendón-Muñiz, Jorge; García-Olvera, Laura

2004-01-01

Pneumonia is the principal cause of morbidity and mortality in PEMEX medical services. Vaccination against influenza is 72% effective in preventing hospitalizations and 87% effective in preventing deaths related to this virus, and vaccination against pneumococcus is 60% effective in preventing invasive diseases by this microorganism. ACIP recommends use of both vaccines simultaneously in adults over 65 years of age. To describe the frequency, duration and severity of local and systemic reactions related to the simultaneous administration of vaccines against influenza and pneumococcus in adults over 55 years of age, and compare with reactions related to influenza vaccine. Two hundred-thirty two adults over 55 years of age were randomly assigned to two groups, group A (114 subjects) received influenza vaccine, group B (118 subjects) received influenza and pneumococcus vaccines simultaneously. Comparing the number of subjects with local reactions on the right arm between groups A and B (17 subjects vs. 27 subjects), differences were not statistically significative (p = 0.121). Systemic reactions were not statistically significative either (p = 0.126) when results were compared between both groups (30 from group A vs. 42 for group B). Simultaneous administration of influenza and pneumococcus vaccines has proven to be safety. In the absence of contraindications, there is no reason for not offering both vaccines in the same medical visit.

Improving the secretion of a methyl parathion hydrolase in Pichia pastoris by modifying its N-terminal sequence.

Directory of Open Access Journals (Sweden)

Ping Wang

Full Text Available Pichia pastoris is commonly used to express and secrete target proteins, although not all recombinant proteins can be successfully produced. In this study, we used methyl parathion hydrolase (MPH from Ochrobactrum sp. M231 as a model to study the importance of the N-terminus of the protein for its secretion. While MPH can be efficiently expressed intracellularly in P. pastoris, it is not secreted into the extracellular environment. Three MPH mutants (N66-MPH, D10-MPH, and N9-MPH were constructed through modification of its N-terminus, and the secretion of each by P. pastoris was improved when compared to wild-type MPH. The level of secreted D10-MPH was increased to 0.21 U/mL, while that of N9-MPH was enhanced to 0.16 U/mL. Although N66-MPH was not enzymatically active, it was secreted efficiently, and was identified by SDS-PAGE. These results demonstrate that the secretion of heterologous proteins in P. pastoris may be improved by modifying their N-terminal structures.

28 CFR 55.23 - Enforcement by the Attorney General.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Enforcement by the Attorney General. 55.23 Section 55.23 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) IMPLEMENTATION OF THE... Attorney General. (a) The Attorney General is authorized to bring civil actions for appropriate relief...

Forced differentiation of CFU-s by iron-55 erythrocytocide

International Nuclear Information System (INIS)

Reincke, U.; Brookoff, D.; Burlington, H.; Cronkite, E.P.

1978-01-01

Cascades of Auger electrons are emitted in the decay of 55 Fe and absorbed in tissue within a 1 μm radius. Cytocidal amounts of 55 Fe can therefore eliminate erythroid precursors with minimal damage to adjacent cells. Early events leave the granuloid series undisturbed but they are accompanied by a precipitous fall of pluripotent stem cells levels (CFU-s) in bone marrow, spleen, and blood. The pretreatment levels of CFU-s are not restored. Gradual decline of CFU-s is associated with intermittently increased turnover rate and reduced settings of cell production, yet unimpaired capacity for quick restoration of blood loss. The precipitous initial stem cell decrease is not caused by irradiation damage as shown in a separate experimental series which uses the frozen-storage cytocide technique. Only over several weeks could 55 Fe radiation accumulate to lethal levels in nondividing stem cells. This irradiation is attributed to incorporation of small amounts of 55 Fe into CFU-s from where it is slowly cleared. The stem cell loss immediately following 55 Fe injection is in our interpretation caused by rapid differentiation along the erythroid pathway in a response that involves all progenitor populations. Data are consistent with the hypothesis of limited cell renewal capacity which thereby gains further support

Binders of intravenously administered zinc 65 in rat liver cytoplasm

International Nuclear Information System (INIS)

Stortenbeek, A.J.; Hamer, C.J.A. van den.

1976-01-01

The fate of intravenously injected trace amounts of 65 Zn 2+ in the rat was studied over a period of ten days after injection. Tissue distributions were determined and a special study was made of 65 Zn-binders in liver cytoplasm. A total of six 65 Zn-binding fractions was found and a tentative identification of the main 65 Zn-binders in these six fractions is given using the collected data regarding their apparent molecular weight, time dependent prominence and content of stable zinc

40 CFR 53.65 - Test procedure: Loading test.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Test procedure: Loading test. 53.65... Characteristics of Class II Equivalent Methods for PM2.5 § 53.65 Test procedure: Loading test. (a) Overview. (1) The loading tests are designed to quantify any appreciable changes in a candidate method sampler's...

Identification and Application of Neutralizing Epitopes of Human Adenovirus Type 55 Hexon Protein

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Xingui Tian

2015-10-01

Full Text Available Human adenovirus type 55 (HAdV55 is a newly identified re-emergent acute respiratory disease (ARD pathogen with a proposed recombination of hexon gene between HAdV11 and HAdV14 strains. The identification of the neutralizing epitopes is important for the surveillance and vaccine development against HAdV55 infection. In this study, four type-specific epitope peptides of HAdV55 hexon protein, A55R1 (residues 138 to 152, A55R2 (residues 179 to 187, A55R4 (residues 247 to 259 and A55R7 (residues 429 to 443, were predicted by multiple sequence alignment and homology modeling methods, and then confirmed with synthetic peptides by enzyme-linked immunosorbent assay (ELISA and neutralization tests (NT. Finally, the A55R2 was incorporated into human adenoviruses 3 (HAdV3 and a chimeric adenovirus rAd3A55R2 was successfully obtained. The chimeric rAd3A55R2 could induce neutralizing antibodies against both HAdV3 and HAdV55. This current study will contribute to the development of novel adenovirus vaccine candidate and adenovirus structural analysis.

Identification and Application of Neutralizing Epitopes of Human Adenovirus Type 55 Hexon Protein

Science.gov (United States)

Tian, Xingui; Ma, Qiang; Jiang, Zaixue; Huang, Junfeng; Liu, Qian; Lu, Xiaomei; Luo, Qingming; Zhou, Rong

2015-01-01

Human adenovirus type 55 (HAdV55) is a newly identified re-emergent acute respiratory disease (ARD) pathogen with a proposed recombination of hexon gene between HAdV11 and HAdV14 strains. The identification of the neutralizing epitopes is important for the surveillance and vaccine development against HAdV55 infection. In this study, four type-specific epitope peptides of HAdV55 hexon protein, A55R1 (residues 138 to 152), A55R2 (residues 179 to 187), A55R4 (residues 247 to 259) and A55R7 (residues 429 to 443), were predicted by multiple sequence alignment and homology modeling methods, and then confirmed with synthetic peptides by enzyme-linked immunosorbent assay (ELISA) and neutralization tests (NT). Finally, the A55R2 was incorporated into human adenoviruses 3 (HAdV3) and a chimeric adenovirus rAd3A55R2 was successfully obtained. The chimeric rAd3A55R2 could induce neutralizing antibodies against both HAdV3 and HAdV55. This current study will contribute to the development of novel adenovirus vaccine candidate and adenovirus structural analysis. PMID:26516903

7 CFR 1775.65 - Eligibility.

Science.gov (United States)

2010-01-01

... (CONTINUED) TECHNICAL ASSISTANCE GRANTS Solid Waste Management Grants § 1775.65 Eligibility. (a) Entities...) Applicants must also have the proven ability; background; experience, as evidenced by the organization's satisfactory completion of project(s) similar to those proposed; legal authority; and actual capacity to...

28 CFR 65.40 - General.

Science.gov (United States)

2010-07-01

... Administration DEPARTMENT OF JUSTICE (CONTINUED) EMERGENCY FEDERAL LAW ENFORCEMENT ASSISTANCE Submission and Review of Applications § 65.40 General. This subpart describes the process and criteria for the Attorney General's review and approval or disapproval of state applications. The original application, on Standard...

Advanced 65 nm CMOS devices fabricated using ultra-low energy plasma doping

International Nuclear Information System (INIS)

Walther, S.; Lenoble, D.; Lallement, F.; Grouillet, A.; Erokhin, Y.; Singh, V.; Testoni, A.

2005-01-01

For leading edge CMOS and DRAM technologies, plasma doping (PLAD) offers several unique advantages over conventional beamline implantation. For ultra-low energy source and drain extensions (SDE), source drain contact and high dose poly doping implants PLAD delivers 2-5x higher throughput compared to beamline implanters. In this work we demonstrate process performance and process integration benefits enabled by plasma doping for advanced 65 nm CMOS devices. Specifically, p + /n ultra-shallow junctions formed with BF 3 plasma doping have superior X j /R s characteristics to beamline implants and yield up to 30% lower R s for 20 nm X j while using standard spike anneal with ramp-up rate of 75 deg. C/s. These results indicate that PLAD could extend applicability of standard spike anneal by at least one technology node past 65 nm. A CMOS split lot has been run to investigate process integration advantages unique to plasma doping and to determine CMOS device characteristics. Device data measured on 65 nm transistors fabricated with offset spacers indicate that devices with SDE formed by plasma doping have superior V t roll-off characteristics arguably due to improved lateral gate-overlap of PLAD SDE junctions. Furthermore, offset spacers could be eliminated in 65 nm devices with PLAD SDE implants while still achieving V t roll-off and I on -I off performance at least equivalent to control devices with offset spacers and SDE formed by beamline implantation. Thus, another advantage of PLAD is simplified 65 nm CMOS manufacturing process flow due to elimination of offset spacers. Finally, we present process transfer from beamline implants to PLAD for several applications, including SDE and gate poly doping with very high productivity

Flash CS5.5 The Missing Manual

CERN Document Server

Grover, Chris

2011-01-01

You can build everything from simple animations to full-fledged iOS and Android apps with Flash CS5.5, but learning this complex program can be difficult-unless you have this fully updated, bestselling guide. Learn how to create gorgeous Flash effects even if you have no programming experience. With Flash CS5.5: The Missing Manual, you'll move from the basics to power-user tools with ease. Learn animation basics. Discover how to turn simple ideas into stunning animations.Master Flash's tools. Learn the animation and effects tools with clear explanations and hands-on examples.Use 3D effects. R

Decline in titers of anti-idiotypic antibodies specific to autoantibodies to GAD65 (GAD65Ab precedes development of GAD65Ab and type 1 diabetes.

Directory of Open Access Journals (Sweden)

Helena Elding Larsson

Full Text Available The humoral Idiotypic Network consisting of antibodies and their anti-idiotypic antibodies (anti-Id can be temporarily upset by antigen exposure. In the healthy immune response the original equilibrium is eventually restored through counter-regulatory mechanisms. In certain autoimmune diseases however, autoantibody levels exceed those of their respective anti-Id, indicating a permanent disturbance in the respective humoral Idiotypic Network. We investigated anti-Id directed to a major Type 1 diabetes (T1D-associated autoantibody (GAD65Ab in two independent cohorts during progression to disease. Samples taken from participants of the Natural History Study showed significantly lower anti-Id levels in individuals that later progressed to T1D compared to non-progressors (anti-Id antibody index of 0.06 vs. 0.08, respectively, p = 0.02. We also observed a significant inverse correlation between anti-Id levels and age at sampling, but only in progressors (p = 0.014. Finally, anti-Id levels in progressors showed a significant decline during progression as compared to longitudinal anti-Id levels in non-progressors (median rate of change: -0.0004 vs. +0.0004, respectively, p = 0.003, suggesting a loss of anti-Id during progression. Our analysis of the Diabetes Prediction in Skåne cohort showed that early in life (age 2 individuals at risk have anti-Id levels indistinguishable from those in healthy controls, indicating that low anti-Id levels are not an innate characteristic of the immune response in individuals at risk. Notably, anti-Id levels declined significantly in individuals that later developed GAD65Ab suggesting that the decline in anti-Id levels precedes the emergence of GAD65Ab (median rate of change: -0.005 compared to matched controls (median rate of change: +0.001 (p = 0.0016. We conclude that while anti-Id are present early in life, their levels decrease prior to the appearance of GAD65Ab and to the development of T1D.

GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus.

Science.gov (United States)

Ludvigsson, Johnny; Krisky, David; Casas, Rosaura; Battelino, Tadej; Castaño, Luis; Greening, James; Kordonouri, Olga; Otonkoski, Timo; Pozzilli, Paolo; Robert, Jean-Jacques; Veeze, Henk J; Palmer, Jerry; Samuelsson, Ulf; Elding Larsson, Helena; Åman, Jan; Kärdell, Gunilla; Neiderud Helsingborg, Jan; Lundström, Göran; Albinsson, Eva; Carlsson, Annelie; Nordvall, Maria; Fors, Hans; Arvidsson, Carl-Göran; Edvardson, Stig; Hanås, Ragnar; Larsson, Karin; Rathsman, Björn; Forsgren, Henrik; Desaix, Helena; Forsander, Gun; Nilsson, Nils-Östen; Åkesson, Carl-Göran; Keskinen, Päivi; Veijola, Riitta; Talvitie, Timo; Raile, Klemens; Kapellen, Thomas; Burger, Walter; Neu, Andreas; Engelsberger, Ilse; Heidtmann, Bettina; Bechtold, Suzanne; Leslie, David; Chiarelli, Francesco; Cicognani, Alesandro; Chiumello, Giuseppe; Cerutti, Franco; Zuccotti, Gian Vincenzo; Gomez Gila, Ana; Rica, Itxaso; Barrio, Raquel; Clemente, Maria; López Garcia, Maria José; Rodriguez, Mercedes; Gonzalez, Isabel; Lopez, Juan Pedro; Oyarzabal, Mirentxu; Reeser, H M; Nuboer, Roos; Stouthart, Pauline; Bratina, Natasa; Bratanic, Nina; de Kerdanet, Marc; Weill, Jacques; Ser, Nicole; Barat, Pascal; Bertrand, Anne Marie; Carel, Jean-Claude; Reynaud, Rachel; Coutant, Regis; Baron, Sabine

2012-02-02

The 65-kD isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes. We hypothesized that alum-formulated GAD65 (GAD-alum) can preserve beta-cell function in patients with recent-onset type 1 diabetes. We studied 334 patients, 10 to 20 years of age, with type 1 diabetes, fasting C-peptide levels of more than 0.3 ng per milliliter (0.1 nmol per liter), and detectable serum GAD65 autoantibodies. Within 3 months after diagnosis, patients were randomly assigned to receive one of three study treatments: four doses of GAD-alum, two doses of GAD-alum followed by two doses of placebo, or four doses of placebo. The primary outcome was the change in the stimulated serum C-peptide level (after a mixed-meal tolerance test) between the baseline visit and the 15-month visit. Secondary outcomes included the glycated hemoglobin level, mean daily insulin dose, rate of hypoglycemia, and fasting and maximum stimulated C-peptide levels. The stimulated C-peptide level declined to a similar degree in all study groups, and the primary outcome at 15 months did not differ significantly between the combined active-drug groups and the placebo group (P=0.10). The use of GAD-alum as compared with placebo did not affect the insulin dose, glycated hemoglobin level, or hypoglycemia rate. Adverse events were infrequent and mild in the three groups, with no significant differences. Treatment with GAD-alum did not significantly reduce the loss of stimulated C peptide or improve clinical outcomes over a 15-month period. (Funded by Diamyd Medical and the Swedish Child Diabetes Foundation; ClinicalTrials.gov number, NCT00723411.).

Elimination of zinc-65 from the brain under kainate-induced seizures.

Science.gov (United States)

Takeda, Atsushi; Hirate, Maki; Oku, Naoto

2004-04-01

On the basis of the previous evidence that 65Zn concentrations in the brain of EL (epilepsy) mice was affected by induction of seizures, 65Zn movement in the brain was quantitatively evaluated in ddY mice treated with kainate. Six days after intravenous injection of 65ZnCl2, mice were intraperitoneally injected with kainate (10 mg/kg x 6 times in 2 weeks). Myoclonic jerks were observed during treatment with kainate. Twenty days after 65Zn injection, 65Zn distribution in the brain was compared between the kainite-treated and control mice. 65Zn distribution in the brain of the kainate-treated mice was overall lower than in the control mice. 65Zn concentration was significantly decreased in the frontal cortex, hippocampal CA1, thalamus and hypothalamus by treatment with kainate. These results demonstrate that kainate-induced seizures are linked to decreased zinc concentrations in the brain.

Prevalence of metabolic syndrome and associated factors in women aged 35 to 65 years who were enrolled in a family health program in Brazil.

Science.gov (United States)

Schmitt, Ana Carolina Basso; Cardoso, Maria Regina Alves; Lopes, Heno; Pereira, Wendry Maria Paixão; Pereira, Elaine Cristina; de Rezende, Debora Aparecida Paccola; Guarizi, Rubia Guibo; Dellu, Mayra Cecilia; Oliveira, Jéssica de Moura; Flauzino, Erika; Blümel, Juan E; Aldrighi, José Mendes

2013-04-01

The aims of this study were to estimate the prevalence of metabolic syndrome among women aged 35 to 65 years and to identify associated factors. This was a cross-sectional study. We randomly selected 581 women (aged 35-65 y) from among those enrolled in a family health program in the city of Pindamonhangaba, Brazil. Metabolic syndrome was identified in accordance with the definition of the National Cholesterol Education Program Adult Treatment Panel III. Health conditions and lifestyle habits were evaluated by a survey, and anthropometric measurements were obtained. The prevalence of metabolic syndrome was estimated, and Poisson regression was used to evaluate the associations between metabolic syndrome `and the factors investigated. The prevalence of metabolic syndrome was 42.2% (95% CI, 38.1-46.2). The most common metabolic syndrome component was abdominal obesity (60.6%), followed by low levels of high-density lipoprotein cholesterol (51.3%), high levels of triglycerides (41.4%), high blood pressure (31.7%), and diabetes (13.9%). The following factors were associated with metabolic syndrome: the 45- to 54-year age group (prevalence ratio, 1.54; 95% CI, 1.08-2.01), the 55- to 65-year age group (prevalence ratio, 3.51; 95% CI, 1.49-3.10), hyperuricemia (prevalence ratio, 2.95; 95% CI, 1.15-1.86), and sleep apnea risk (prevalence ratio, 2.41; 95% CI, 1.16-1.82). We found an inverse association between metabolic syndrome and having had more than 5 years of schooling (prevalence ratio, 0.65; 95% CI, 0.65-1.04). The prevalence of metabolic syndrome is high, and the associated clinical factors are hyperuricemia and risk of sleep apnea.

14 CFR 65.43 - Rating privileges and exchange.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Rating privileges and exchange. 65.43... § 65.43 Rating privileges and exchange. (a) The holder of a senior rating on August 31, 1970, may at any time after that date exchange his rating for a facility rating at the same air traffic control...

10 CFR 26.65 - Pre-access drug and alcohol testing.

Science.gov (United States)

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Pre-access drug and alcohol testing. 26.65 Section 26.65... § 26.65 Pre-access drug and alcohol testing. (a) Purpose. This section contains pre-access testing... days. If an individual has negative results from drug and alcohol tests that were conducted under the...

7 CFR 201.55 - Retests.

Science.gov (United States)

2010-01-01

... Germination Tests in the Administration of the Act § 201.55 Retests. Retests shall be made as follows: (a) When the range of 100-seed replicates of a given test exceeds the maximum tolerated range in the table... replicates of a given test, rounding off the result to the nearest whole number. The germination is found in...

Density functional investigation of the adsorption effects of PH3 and SH2 on the structure stability of the Au55 and Pt55 nanoclusters

Science.gov (United States)

Guedes-Sobrinho, Diego; Chaves, Anderson S.; Piotrowski, Maurício J.; Da Silva, Juarez L. F.

2017-04-01

Although several studies have been reported for Pt55 and Au55 nanoclusters, our atomistic understanding of the interplay between the adsorbate-surface interactions and the mechanisms that lead to the formation of the distorted reduced core (DRC) structures, instead of the icosahedron (ICO) structure in gas phase, is still far from satisfactory. Here, we report a density functional theory (DFT) investigation of the role of the adsorption effects of PH3 (one lone pair of electrons) and SH2 (two lone pairs) on the relative stability of the Pt55 and Au55 nanoclusters. In gas phase, we found that the DRC structures with 7 and 9 atoms in the core region are about 5.34 eV (Pt55) and 2.20 eV (Au55) lower in energy than the ICO model with Ih symmetry and 13 atoms in the core region. However, the stability of the ICO structure increases by increasing the number of adsorbed molecules from 1 to 18, in which both DRC and ICO structures are nearly degenerate in energy at the limit of 18 ligands, which can be explained as follows. In gas phase, there is a strong compression of the cationic core region by the anionic surface atoms induced by the attractive Coulomb interactions (core+-surface-), and hence, the strain release is obtained by reducing the number of atoms in the cationic core region, which leads to the 55 atoms distorted reduced core structures. Thus, the Coulomb interactions between the core+ and surface- contribute to break the symmetry in the ICO55 structure. On the other hand, the addition of ligands on the anionic surface reduces the charge transfer between the core and surface, which contributes to decrease the Coulomb interactions and the strain on the core region of the ICO structure, and hence, it stabilizes a compact ICO structure. The same conclusion is obtained by adding van der Waals corrections to the plain DFT calculations. Similar results are obtained by the addition of steric effects, which are considered through the adsorption of triphenylphosphine

49 CFR 1242.55 - Administration (account XX-51-01).

Science.gov (United States)

2010-10-01

... 49 Transportation 9 2010-10-01 2010-10-01 false Administration (account XX-51-01). 1242.55 Section...-Transportation § 1242.55 Administration (account XX-51-01). Separate common expenses according to distribution of common expenses in the following accounts: Engine Crews (XX-51-56) Train Crews (XX-51-57) Dispatching...

25 CFR 700.55 - Decent, safe, and sanitary dwelling.

Science.gov (United States)

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false Decent, safe, and sanitary dwelling. 700.55 Section 700... PROCEDURES General Policies and Instructions Definitions § 700.55 Decent, safe, and sanitary dwelling. (a) General. The term decent, safe, and sanitary dwelling means a dwelling which— (1) Meets applicable federal...

33 CFR 55.5 - Who is eligible for child development services?

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2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Who is eligible for child development services? 55.5 Section 55.5 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PERSONNEL CHILD DEVELOPMENT SERVICES General § 55.5 Who is eligible for child development services...

Crystallization and preliminary X-ray analysis of coagulation factor IX-binding protein from habu snake venom at pH 6.5 and 4.6

International Nuclear Information System (INIS)

Suzuki, Nobuhiro; Shikamoto, Yasuo; Fujimoto, Zui; Morita, Takashi; Mizuno, Hiroshi

2004-01-01

Crystals of habu coagulation factor IX-binding protein have been obtained at pH 6.5 and 4.6 and characterized by X-ray diffraction. Coagulation factor IX-binding protein isolated from Trimeresurus flavoviridis (IX-bp) is a C-type lectin-like protein. It is an anticoagulant protein consisting of homologous subunits A and B. The subunits both contain a Ca 2+ -binding site with differing affinity (K d values of 14 and 130 µM at pH 7.5). These binding characteristics are pH-dependent; under acidic conditions, the affinity of the low-affinity site was reduced considerably. In order to identify which site has high affinity and also to investigate the Ca 2+ -releasing mechanism, IX-bp was crystallized at pH 6.5 and 4.6. The crystals at pH 6.5 and 4.6 diffracted to 1.72 and 2.29 Å resolution, respectively; the former crystals belong to the monoclinic space group P2 1 , with unit-cell parameters a = 60.7, b = 63.5, c = 66.9 Å, β = 117.0°, while the latter belong to the monoclinic space group C2, with a = 134.1, b = 37.8, c = 55.8 Å, β = 110.4°

Labour force activity after 65: what explain recent trends in Denmark, Germany and Sweden?

Science.gov (United States)

Larsen, Mona; Pedersen, Peder J

2017-01-01

In most OECD member countries labour force attachment, has increased in recent years not only in the age groups 60-64 years but also among people 65 years and older. Focus in this paper is on the trend in older workers' labour force participation in Denmark, Germany and Sweden since 2004. Main emphasis is given to people aged 65-69 years eligible for social security retirement programs from age 65. The gender aspect is included to accommodate different trends for women and men. To explain country differences in trends, the importance of changes in retirement policies of relevance for this age group and cohort relevant changes in education and health is examined and discussed. Further, country differences in the impact from education and health is examined. Results show that the largest increase in labour force participation among people aged 65-69 years has taken place in Sweden following by Germany, while the increase in Denmark is rather small. While the increase in Germany mainly seems to be a result of policy reforms, the increase in Sweden appear to be a result of a combination of policy changes and an increasing educational level. Financial incentives seem most important in Germany and only of minor importance in Denmark, where policy changes directed towards individuals above the age of 65 appear to have been too small so far to affect retirement behaviour significantly.

Methylphenidate disintegration from oral formulations for intravenous use by experienced substance users.

Science.gov (United States)

Bjarnadottir, G D; Johannsson, M; Magnusson, A; Rafnar, B O; Sigurdsson, E; Steingrimsson, S; Asgrimsson, V; Snorradottir, I; Bragadottir, H; Haraldsson, H M

2017-09-01

Methylphenidate (MPH) is a prescription stimulant used to treat attention-deficit hyperactivity disorder. MPH is currently the preferred substance among most intravenous (i.v.) substance users in Iceland. Four types of MPH preparations were available in Iceland at the time of study: Immediate-release (IR), sustained-release (SR), osmotic controlled-release oral delivery (OROS) tablet and osmotic-controlled release (OCR). MPH OROS has previously been rated the least desirable by i.v. users and we hypothesized that this was associated with difficulty of disintegrating MPH from OROS formulation. The aim of the study was to measure the amount of MPH and the viscosity of the disintegrated solutions that were made from the four MPH formulations by four i.v.-users and non-users. A convenience sample of four i.v. substance users and 12 non-users. Non-users imitated the methods applied by experienced i.v. substance users for disintegrated MPH formulations. Both groups managed to disintegrate over 50% of MPH from IR and SR formulations but only 20% from OROS (pusers and non-users. To our knowledge, this is the first investigation of viscosity and the amount of disintegrated MPH from prescription drugs for i.v. use. The results indicate that the ease of disintegration, amount of MPH and viscosity may explain the difference in popularity for i.v. use between different MPH formulations. Copyright © 2017 Elsevier B.V. All rights reserved.

10 CFR 39.55 - Tritium neutron generator target sources.

Science.gov (United States)

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Tritium neutron generator target sources. 39.55 Section 39... Equipment § 39.55 Tritium neutron generator target sources. (a) Use of a tritium neutron generator target....77. (b) Use of a tritium neutron generator target source, containing quantities exceeding 1,110 GBg...

55th International Conference of Machine Design Departments 2014

CERN Document Server

Berka, Ondrej; Petr, Karel; Lopot, František; Dub, Martin

2016-01-01

This book is based on the 55th International Conference of Machine Design Departments 2014 (ICMD 2014) which was hosted by the Czech Technical University in September 2014. It features scientific articles which solve progressive themes from the field of machine design. The book addresses a broad range of themes including tribology, hydraulics, materials science, product innovation and experimental methods. It presents the latest interdisciplinary high-tech work. People with an interest in the latest research results in the field of machine design and manufacturing engineering will value this book with contributions of leading academic scientists and experts from all around the world.

Regulation of zebrafish CYP3A65 transcription by AHR2

International Nuclear Information System (INIS)

Chang, Chin-Teng; Chung, Hsin-Yu; Su, Hsiao-Ting; Tseng, Hua-Pin; Tzou, Wen-Shyong; Hu, Chin-Hwa

2013-01-01

CYP3A proteins are the most abundant CYPs in the liver and intestines, and they play a pivotal role in drug metabolism. In mammals, CYP3A genes are induced by various xenobiotics through processes mediated by PXR. We previously identified zebrafish CYP3A65 as a CYP3A ortholog that is constitutively expressed in gastrointestinal tissues, and is upregulated by treatment with dexamethasone, rifampicin or tetrachlorodibenzo-p-dioxin (TCDD). However, the underlying mechanism of TCDD-mediated CYP3A65 transcription is unclear. Here we generated two transgenic zebrafish, Tg(CYP3A65S:EGFP) and Tg(CYP3A65L:EGFP), which contain 2.1 and 5.4 kb 5′ flanking sequences, respectively, of the CYP3A65 gene upstream of EGFP. Both transgenic lines express EGFP in larval gastrointestinal tissues in a pattern similar to that of the endogenous CYP3A65 gene. Moreover, EGFP expression can be significantly induced by TCDD exposure during the larval stage. In addition, EGFP expression can be stimulated by kynurenine, a putative AHR ligand produced during tryptophan metabolism. AHRE elements in the upstream regulatory region of the CYP3A65 gene are indispensible for basal and TCDD-induced transcription. Furthermore, the AHR2 DNA and ligand-binding domains are required to mediate effective CYP3A65 transcription. AHRE sequences are present in the promoters of many teleost CYP3 genes, but not of mammalian CYP3 genes, suggesting that AHR/AHR2-mediated transcription is likely a common regulatory mechanism for teleost CYP3 genes. It may also reflect the different environments that terrestrial and aquatic organisms encounter. - Highlights: • Tg(CYP3A65:EGFP) and CYP3A65 exhibits identical expression pattern. • CYP3A65 can be significantly induced by TCDD or kynurenine. • The AHRE elements are required to mediate CYP3A65 transcription. • The AHR2 DNA and ligand-binding domains are required for CYP3A65 transcription. • AHRE elements are present in many teleost CYP3 genes, but not in

Regulation of zebrafish CYP3A65 transcription by AHR2

Energy Technology Data Exchange (ETDEWEB)

Chang, Chin-Teng; Chung, Hsin-Yu; Su, Hsiao-Ting; Tseng, Hua-Pin [Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan (China); Tzou, Wen-Shyong [Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan (China); Center of Excellence for Marine Bioenvironment and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan (China); Hu, Chin-Hwa, E-mail: chhu@mail.ntou.edu.tw [Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan (China); Center of Excellence for Marine Bioenvironment and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan (China)

2013-07-15

CYP3A proteins are the most abundant CYPs in the liver and intestines, and they play a pivotal role in drug metabolism. In mammals, CYP3A genes are induced by various xenobiotics through processes mediated by PXR. We previously identified zebrafish CYP3A65 as a CYP3A ortholog that is constitutively expressed in gastrointestinal tissues, and is upregulated by treatment with dexamethasone, rifampicin or tetrachlorodibenzo-p-dioxin (TCDD). However, the underlying mechanism of TCDD-mediated CYP3A65 transcription is unclear. Here we generated two transgenic zebrafish, Tg(CYP3A65S:EGFP) and Tg(CYP3A65L:EGFP), which contain 2.1 and 5.4 kb 5′ flanking sequences, respectively, of the CYP3A65 gene upstream of EGFP. Both transgenic lines express EGFP in larval gastrointestinal tissues in a pattern similar to that of the endogenous CYP3A65 gene. Moreover, EGFP expression can be significantly induced by TCDD exposure during the larval stage. In addition, EGFP expression can be stimulated by kynurenine, a putative AHR ligand produced during tryptophan metabolism. AHRE elements in the upstream regulatory region of the CYP3A65 gene are indispensible for basal and TCDD-induced transcription. Furthermore, the AHR2 DNA and ligand-binding domains are required to mediate effective CYP3A65 transcription. AHRE sequences are present in the promoters of many teleost CYP3 genes, but not of mammalian CYP3 genes, suggesting that AHR/AHR2-mediated transcription is likely a common regulatory mechanism for teleost CYP3 genes. It may also reflect the different environments that terrestrial and aquatic organisms encounter. - Highlights: • Tg(CYP3A65:EGFP) and CYP3A65 exhibits identical expression pattern. • CYP3A65 can be significantly induced by TCDD or kynurenine. • The AHRE elements are required to mediate CYP3A65 transcription. • The AHR2 DNA and ligand-binding domains are required for CYP3A65 transcription. • AHRE elements are present in many teleost CYP3 genes, but not in

Molecular Basis of Resistance to Selected Antimicrobial Agents in the Emerging Zoonotic Pathogen Streptococcus suis.

Science.gov (United States)

Gurung, Mamata; Tamang, Migma Dorji; Moon, Dong Chan; Kim, Su-Ran; Jeong, Jin-Ha; Jang, Geum-Chan; Jung, Suk-Chan; Park, Yong-Ho; Lim, Suk-Kyung

2015-07-01

Characterization of 227 Streptococcus suis strains isolated from pigs during 2010 to 2013 showed high levels of resistance to clindamycin (95.6%), tilmicosin (94.7%), tylosin (93.8%), oxytetracycline (89.4%), chlortetracycline (86.8%), tiamulin (72.7%), neomycin (70.0%), enrofloxacin (56.4%), penicillin (56.4%), ceftiofur (55.9%), and gentamicin (55.1%). Resistance to tetracyclines, macrolides, aminoglycosides, and fluoroquinolone was attributed to the tet gene, erm(B), erm(C), mph(C), and mef(A) and/or mef(E) genes, aph(3')-IIIa and aac(6')-Ie-aph(2″)-Ia genes, and single point mutations in the quinolone resistance-determining region of ParC and GyrA, respectively. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

29 CFR 4003.55 - Opportunity to appear and to present witnesses.

Science.gov (United States)

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Opportunity to appear and to present witnesses. 4003.55 Section 4003.55 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION GENERAL RULES FOR ADMINISTRATIVE REVIEW OF AGENCY DECISIONS Administrative Appeals § 4003.55 Opportunity to appear and to present witnesses. (a) At the...

24 CFR 55.11 - Applicability of subpart C decision making process.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Applicability of subpart C decision making process. 55.11 Section 55.11 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development FLOODPLAIN MANAGEMENT Application of Executive Order on Floodplain Management § 55.11 Applicability of subpart C...

On the Mechanism of Berberine-INF55 (5-Nitro-2-phenylindole) Hybrid Antibacterials.

Science.gov (United States)

Dolla, Naveen K; Chen, Chao; Larkins-Ford, Jonah; Rajamuthiah, Rajmohan; Jagadeesan, Sakthimala; Conery, Annie L; Ausubel, Frederick M; Mylonakis, Eleftherios; Bremner, John B; Lewis, Kim; Kelso, Michael J

Berberine-INF55 hybrids are a promising class of antibacterials that combine berberine and the NorA multidrug resistance pump inhibitor INF55 (5-nitro-2-phenylindole) together in one molecule via a chemically stable linkage. Previous studies demonstrated the potential of these compounds for countering efflux-mediated antibacterial drug resistance but they didn't establish whether the compounds function as originally intended, i.e. with the berberine moiety providing antibacterial activity and the attached INF55 component independently blocking multidrug resistance pumps, thereby enhancing the activity of berberine by reducing its efflux. We hypothesised that if the proposed mechanism is correct, then hybrids carrying more potent INF55 pump inhibitor structures should show enhanced antibacterial effects relative to those bearing weaker inhibitors. Two INF55 analogues showing graded reductions in NorA inhibitory activity compared with INF55 were identified and their corresponding berberine-INF55 hybrids carrying equivalent INF55 inhibitor structures synthesised. Multiple assays comparing the antibacterial effects of the hybrids and their corresponding berberine-INF55 analogue combinations showed that the three hybrids all show very similar activities, leading us to conclude that the antibacterial mechanism(s) of berberine-INF55 hybrids is different from berberine-INF55 combinations.

Overexpression of p65 attenuates celecoxib-induced cell death in MDA-MB-231 human breast cancer cell line

Directory of Open Access Journals (Sweden)

Wang Ling

2013-02-01

Full Text Available Abstract Background Celecoxib is a selective cyclooxygenase (COX-2 inhibitor that has been reported to reduce the risk of breast cancer. In our previous study, celecoxib induced apoptosis and caused cell cycle arrest at the G0/G1 phase in the breast cancer cell line MDA-MB-231, and its effects were mediated by downregulation of NF-κB signaling. The NF-κB p65/RelA subunit may play a role in cell death through the activation of anti-apoptotic target genes including the inhibitor of apoptosis (IAP and Bcl-2 families, and inhibition of protein kinase B/Akt. The aim of the present study was to investigate p65 as the potential target of celecoxib treatment and determine whether p65 overexpression can override the inhibitory effect of celecoxib on NF-κB activity and affect cell survival. Methods The effects of p65 overexpression on celecoxib-inhibited NF-κB transcriptional activity were examined by western blotting, electrophoretic mobility shift assay (EMSA and luciferase reporter gene assay. Cell viability and cell death were evaluated by the 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazoliumbromide (MTT assay, and the levels of cleaved poly(ADP-ribose polymerase (PARP and caspase. Anti-apoptotic NF-κB target genes and cell cycle regulators were examined by western blotting to screen for the expression of target genes under direct regulation by p65. Results Overexpression of p65 increased NF-κB transcriptional activity and interfered with celecoxib-mediated apoptosis as assessed by MTT assay and caspase-3, caspase-9, and PARP expressions. Exogenously overexpressed p65 upregulated NF-κB-responsive genes, including anti-apoptotic genes such as survivin and XIAP, and the cell cycle regulatory gene cyclin D1. However, p65 overexpression did not affect celecoxib-induced p-Akt inactivation, suggesting that celecoxib might have separate molecular mechanisms for regulating Akt signaling independently of its inhibition of NF-κB transcriptional

10 CFR 61.55 - Waste classification.

Science.gov (United States)

2010-01-01

... REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.55 Waste classification. (a) Classification of waste for near surface disposal—(1) Considerations. Determination of the classification of radioactive waste involves two...

49 CFR 192.55 - Steel pipe.

Science.gov (United States)

2010-10-01

... Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Materials § 192.55 Steel pipe. (a) New steel pipe is...

Alzheimer's Disease Facts and Figures

Medline Plus

Full Text Available ... This number includes an estimated 5.5 million people age 65 and older and approximately 200,000 ... who have younger-onset Alzheimer's. One in 10 people age 65 and older (10 percent) has Alzheimer's ...

40 CFR 60.55a - Standard for nitrogen oxides.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Standard for nitrogen oxides. 60.55a... § 60.55a Standard for nitrogen oxides. On and after the date on which the initial compliance test is... gases that contain nitrogen oxides in excess of 180 parts per million by volume, corrected to 7 percent...

Evaluation of highly conserved hsp65-specific nested PCR primers for diagnosing Mycobacterium tuberculosis.

Science.gov (United States)

Priyadarshini, P; Tiwari, K; Das, A; Kumar, D; Mishra, M N; Desikan, P; Nath, G

2017-02-01

To evaluate the sensitivity and specificity of a new nested set of primers designed for the detection of Mycobacterium tuberculosis complex targeting a highly conserved heat shock protein gene (hsp65). The nested primers were designed using multiple sequence alignment assuming the nucleotide sequence of the M. tuberculosis H37Rv hsp65 genome as base. Multidrug-resistant Mycobacterium species along with other non-mycobacterial and fungal species were included to evaluate the specificity of M. tuberculosis hsp65 gene-specific primers. The sensitivity of the primers was determined using serial 10-fold dilutions, and was 100% as shown by the bands in the case of M. tuberculosis complex. None of the other non M. tuberculosis complex bacterial and fungal species yielded any band on nested polymerase chain reaction (PCR). The first round of amplification could amplify 0.3 ng of the template DNA, while nested PCR could detect 0.3 pg. The present hsp65-specific primers have been observed to be sensitive, specific and cost-effective, without requiring interpretation of biochemical tests, real-time PCR, sequencing or high-performance liquid chromatography. These primer sets do not have the drawbacks associated with those protocols that target insertion sequence 6110, 16S rDNA, rpoB, recA and MPT 64.

Mena-GRASP65 interaction couples actin polymerization to Golgi ribbon linking.

Science.gov (United States)

Tang, Danming; Zhang, Xiaoyan; Huang, Shijiao; Yuan, Hebao; Li, Jie; Wang, Yanzhuang

2016-01-01

In mammalian cells, the Golgi reassembly stacking protein 65 (GRASP65) has been implicated in both Golgi stacking and ribbon linking by forming trans-oligomers through the N-terminal GRASP domain. Because the GRASP domain is globular and relatively small, but the gaps between stacks are large and heterogeneous, it remains puzzling how GRASP65 physically links Golgi stacks into a ribbon. To explore the possibility that other proteins may help GRASP65 in ribbon linking, we used biochemical methods and identified the actin elongation factor Mena as a novel GRASP65-binding protein. Mena is recruited onto the Golgi membranes through interaction with GRASP65. Depleting Mena or disrupting actin polymerization resulted in Golgi fragmentation. In cells, Mena and actin were required for Golgi ribbon formation after nocodazole washout; in vitro, Mena and microfilaments enhanced GRASP65 oligomerization and Golgi membrane fusion. Thus Mena interacts with GRASP65 to promote local actin polymerization, which facilitates Golgi ribbon linking. © 2016 Tang et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Density functional investigation of the adsorption effects of PH3 and SH2 on the structure stability of the Au55 and Pt55 nanoclusters.

Science.gov (United States)

Guedes-Sobrinho, Diego; Chaves, Anderson S; Piotrowski, Maurício J; Da Silva, Juarez L F

2017-04-28

Although several studies have been reported for Pt 55 and Au 55 nanoclusters, our atomistic understanding of the interplay between the adsorbate-surface interactions and the mechanisms that lead to the formation of the distorted reduced core (DRC) structures, instead of the icosahedron (ICO) structure in gas phase, is still far from satisfactory. Here, we report a density functional theory (DFT) investigation of the role of the adsorption effects of PH 3 (one lone pair of electrons) and SH 2 (two lone pairs) on the relative stability of the Pt 55 and Au 55 nanoclusters. In gas phase, we found that the DRC structures with 7 and 9 atoms in the core region are about 5.34 eV (Pt 55 ) and 2.20 eV (Au 55 ) lower in energy than the ICO model with I h symmetry and 13 atoms in the core region. However, the stability of the ICO structure increases by increasing the number of adsorbed molecules from 1 to 18, in which both DRC and ICO structures are nearly degenerate in energy at the limit of 18 ligands, which can be explained as follows. In gas phase, there is a strong compression of the cationic core region by the anionic surface atoms induced by the attractive Coulomb interactions (core + -surface - ), and hence, the strain release is obtained by reducing the number of atoms in the cationic core region, which leads to the 55 atoms distorted reduced core structures. Thus, the Coulomb interactions between the core + and surface - contribute to break the symmetry in the ICO 55 structure. On the other hand, the addition of ligands on the anionic surface reduces the charge transfer between the core and surface, which contributes to decrease the Coulomb interactions and the strain on the core region of the ICO structure, and hence, it stabilizes a compact ICO structure. The same conclusion is obtained by adding van der Waals corrections to the plain DFT calculations. Similar results are obtained by the addition of steric effects, which are considered through the adsorption of

Deletion of G-protein-coupled receptor 55 promotes obesity by reducing physical activity.

Science.gov (United States)

Meadows, A; Lee, J H; Wu, C-S; Wei, Q; Pradhan, G; Yafi, M; Lu, H-C; Sun, Y

2016-03-01

Cannabinoid receptor 1 (CB1) is the best-characterized cannabinoid receptor, and CB1 antagonists are used in clinical trials to treat obesity. Because of the wide range of CB1 functions, the side effects of CB1 antagonists pose serious concerns. G-protein-coupled receptor 55 (GPR55) is an atypical cannabinoid receptor, and its pharmacology and functions are distinct from CB1. GPR55 regulates neuropathic pain, gut, bone, immune functions and motor coordination. GPR55 is expressed in various brain regions and peripheral tissues. However, the roles of GPR55 in energy and glucose homeostasis are unknown. Here we have investigated the roles of GPR55 in energy balance and insulin sensitivity using GPR55-null mice (GPR55(-/-)). Body composition of the mice was measured by EchoMRI. Food intake, feeding behavior, energy expenditure and physical activity of GPR55(-/-) mice were determined by indirect calorimetry. Muscle function was assessed by forced treadmill running test. Insulin sensitivity was evaluated by glucose and insulin tolerance tests. Adipose inflammation was assessed by flow cytometry analysis of adipose tissue macrophages. The expression of inflammatory markers in adipose tissues and orexigenic/anorexigenic peptides in the hypothalamus was also analyzed by real-time PCR. GPR55(-/-) mice had normal total energy intake and feeding pattern (i.e., no changes in meal size, meal number or feeding frequency). Intriguingly, whereas adult GPR55(-/-) mice only showed a modest increase in overall body weight, they exhibited significantly increased fat mass and insulin resistance. The spontaneous locomotor activity of GPR55(-/-) mice was dramatically decreased, whereas resting metabolic rate and non-shivering thermogenesis were unchanged. Moreover, GPR55(-/-) mice exhibited significantly decreased voluntary physical activity, showing reduced running distance on the running wheels, whereas muscle function appeared to be normal. GPR55 has an important role in energy

Malignant peritoneal esothelioma masqueradesas peritoneal metastasis on {sup 18}F-FDG PET/CT scans: A rare diagnosis that should not be missed

Energy Technology Data Exchange (ETDEWEB)

Claimon, Apichaya; Bang, Ji In; Cheon, Gi Jeong; Lee, Dong Soo [Dept. of Nuclear Medicine, Seoul National University Hospital, Seoul (Korea, Republic of); Kim, Eui Shin Edmund [Molecular Medicine and Biopharmaceutical Sciences, WCU Graduate School of Convergence Science and Technology, Seoul National University College of Medicine, Seoul (Korea, Republic of)

2015-12-15

Malignant peritoneal mesothelioma (MPM) is a rare but fatal tumor. The clinical presentations and imaging findings are nonspecific and resemble various diseases, including peritoneal metastasis. Imaging findings of MPH on {sup 18}F-{sup 18}F-fluorodeoxyglucose ({sup 18}F-FDG) positron emission tomography (PET)/computed tomography (CT) are diverse and not well described. We report the two cases of biopsy-proven MPH using {sup 18}F-FDG PET/CT. In our cases, interesting disease patterns—including MPH arising from visceral peritoneal lining of kidney that suffer from polycystic disease and from the parietal peritoneum beneath the appendectomy scar—were presented. One case showed classical metastases localized within the abdominal cavity; while the other case exhibited the rare pattern of extensive multi-organ metastases. By knowing the possible variations and diagnostic pitfalls of {sup 18}F-FDG PET/CT findings in MPM, more accurate interpretation of such mysterious cancer is attainable.

Electrochemical properties of the MmNi3.55Mn0.4Al0.3Co0.75-xFex (x = 0.55 and 0.75) compounds

International Nuclear Information System (INIS)

Ben Moussa, M.; Abdellaoui, M.; Mathlouthi, H.; Lamloumi, J.; Guegan, A. Percheron

2008-01-01

The hydrogen storage alloys MmNi 3.55 Mn 0.4 Al 0.3 Co 0.75-x Fe x (x = 0.55 and 0.75) were used as negative electrodes in the Ni-MH accumulators. The chronopotentiommetry and the cyclic voltammetry were applied to characterize the electrochemical properties of these alloys. The obtained results showed that the substitution of the cobalt atoms by iron atoms has a good effect on the life cycle of the electrode. For the MmNi 3.55 Mn 0.4 Al 0.3 Co 0.2 Fe 0.55 compound, the discharge capacity reaches its maximum of 210 mAh/g after 12 cycles and then decreases to 190 mAh/g after 30 charge-discharge cycles. However, for the MmNi 3.55 Mn 0.4 Al 0.3 Fe 0.75 compound, the discharge capacity reaches its maximum of 200 mAh/g after 10 cycles and then decreases to 160 mAh/g after 30 cycles. The diffusion behavior of hydrogen in the negative electrodes made from these alloys was characterized by cyclic voltammetry after few activation cycles. The values of the hydrogen coefficient in MmNi 3.55 Mn 0.4 Al 0.3 Co 0.2 Fe 0.55 and MmNi 3.55 Mn 0.4 Al 0.3 Fe 0.75 are, respectively, equal to 2.96 x 10 -9 and 4.98 x 10 -10 cm 2 s -1 . However, the values of the charge transfer coefficients are, respectively, equal to 0.33 and 0.3. These results showed that the substitution of cobalt by iron decreases the reversibility and the kinetic of the electrochemical reaction in these alloys

The thermodynamics of Pr55Gag-RNA interaction regulate the assembly of HIV.

Directory of Open Access Journals (Sweden)

Hanumant S Tanwar

2017-02-01

Full Text Available The interactions that occur during HIV Pr55Gag oligomerization and genomic RNA packaging are essential elements that facilitate HIV assembly. However, mechanistic details of these interactions are not clearly defined. Here, we overcome previous limitations in producing large quantities of full-length recombinant Pr55Gag that is required for isothermal titration calorimetry (ITC studies, and we have revealed the thermodynamic properties of HIV assembly for the first time. Thermodynamic analysis showed that the binding between RNA and HIV Pr55Gag is an energetically favourable reaction (ΔG<0 that is further enhanced by the oligomerization of Pr55Gag. The change in enthalpy (ΔH widens sequentially from: (1 Pr55Gag-Psi RNA binding during HIV genome selection; to (2 Pr55Gag-Guanosine Uridine (GU-containing RNA binding in cytoplasm/plasma membrane; and then to (3 Pr55Gag-Adenosine(A-containing RNA binding in immature HIV. These data imply the stepwise increments of heat being released during HIV biogenesis may help to facilitate the process of viral assembly. By mimicking the interactions between A-containing RNA and oligomeric Pr55Gag in immature HIV, it was noted that a p6 domain truncated Pr50Gag Δp6 is less efficient than full-length Pr55Gag in this thermodynamic process. These data suggest a potential unknown role of p6 in Pr55Gag-Pr55Gag oligomerization and/or Pr55Gag-RNA interaction during HIV assembly. Our data provide direct evidence on how nucleic acid sequences and the oligomeric state of Pr55Gag regulate HIV assembly.

A Concept for the Use and Integration of Super-Conducting Magnets in Structural Systems in General and Maglev Guideway Mega-Structures in Particular

Science.gov (United States)

Ussery, Wilfred T.; MacCalla, Eric; MacCalla, Johnetta; Elnimeiri, Mahjoub; Goldsmith, Myron; Polk, Sharon Madison; Jenkins, Mozella; Bragg, Robert H.

1996-01-01

Recent breakthroughs in several different fields now make it possible to incorporate the use of superconducting magnets in structures in ways which enhance the performance of structural members or components of structural systems in general and Maglev guideway mega-structures in particular. The building of structural systems which connect appropriately scaled superconducting magnets with the post-tensioned tensile components of beams, girders, or columns would, if coupled with 'state of the art' structure monitoring, feedback and control systems, and advanced computer software, constitute a distinct new generation of structures that would possess the unique characteristic of being heuristic and demand or live-load responsive. The holistic integration of powerful superconducting magnets in structures so that they do actual structural work, creates a class of 'technologically endowed' structures that, in part - literally substitute superconductive electric power and magnetism for concrete and steel. The research and development engineering, and architectural design issues associated with such 'technologically endowed' structural system can now be conceptualized, designed, computer simulates built and tested. The Maglev guideway mega-structure delineated herein incorporates these concepts, and is designed for operation in the median strip of U.S. Interstate Highway 5 from San Diego to Seattle an Vancouver, and possibly on to Fairbanks, Alaska. This system also fits in the median strip of U.S. Interstate Highway 55 and 95 North-South, and 80 and 10, East-West. As a Western Region 'Peace Dividend' project, it could become a National or Bi-National research, design and build, super turnkey project that would create thousands of jobs by applying superconducting, material science, electronic aerospace and other defense industry technologies to a multi-vehicle, multi-use Maglev guideway megastructure that integrates urban mass transit Lower Speed (0-100 mph), High Speed

Assessing the Quality of Steady-state Visual-evoked Potentials for Moving Humans Using a Mobile Electroencephalogram Headset

Directory of Open Access Journals (Sweden)

Yuan-Pin eLin

2014-03-01

Full Text Available Recent advances in mobile electroencephalogram (EEG systems, featuring non-prep dry electrodes and wireless telemetry, have urged the needs of mobile brain-computer interfaces (BCIs for applications in our daily life. Since the brain may behave differently while people are actively situated in ecologically-valid environments versus highly-controlled laboratory environments, it remains unclear how well the current laboratory-oriented BCI demonstrations can be translated into operational BCIs for users with naturalistic movements. Understanding inherent links between natural human behaviors and brain activities is the key to ensuring the applicability and stability of mobile BCIs. This study aims to assess the quality of steady-state visual-evoked potentials (SSVEPs, which is one of promising channels for functioning BCI systems, recorded using a mobile EEG system under challenging recording conditions, e.g., walking. To systemati-cally explore the effects of walking locomotion on the SSVEPs, this study instructed subjects to stand or walk on a treadmill running at speeds of 1, 2, and 3 mile (s per hour (MPH while con-currently perceiving visual flickers (11 and 12 Hz. Empirical results of this study showed that the SSVEP amplitude tended to deteriorate when subjects switched from standing to walking. Such SSVEP suppression could be attributed to the walking locomotion, leading to distinctly deteriorated SSVEP detectability from standing (84.87±13.55% to walking (1 MPH: 83.03±13.24%, 2 MPH: 79.47±13.53%, and 3 MPH: 75.26±17.89%. These findings not only demonstrated the applicability and limitations of SSVEPs recorded from freely behaving humans in realistic environments, but also provide useful methods and techniques for boosting the translation of the BCI technology from laboratory demonstrations to practical applications.

24 CFR 92.65 - Funding sanctions.

Science.gov (United States)

2010-04-01

... HOME INVESTMENT PARTNERSHIPS PROGRAM Allocation Formula Insular Areas Program § 92.65 Funding sanctions... assistance where any corrective or remedial actions taken under § 92.551 fail to remedy an insular area's...

46 CFR 7.55 - Cape Henry, VA to Cape Fear, NC.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Cape Henry, VA to Cape Fear, NC. 7.55 Section 7.55 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.55 Cape Henry, VA to Cape Fear, NC. (a) A line drawn from Rudee Inlet Jetty Light “2” to...

The effects of methylphenidate on cognitive performance of healthy male rats

Directory of Open Access Journals (Sweden)

Claire Louise Rostron

2013-06-01

Full Text Available We aimed to investigate the effects of methylphenidate (MPH in healthy rats on two distinct radial maze tasks which rely on brain structures and neurotransmitters known to be affected by MPH: the Random Foraging Non-Delay Task (RFNDT and the Delay Spatial Win Shift Task (DSWT. Hooded Lister rats were trained to complete either the RFNDT or the DSWT having received oral treatment of either a vehicle or MPH (3.0 mg/kg and 5.0 mg/kg for RFNDT, 3.0 mg/kg for DSWT. We found no effect of MPH on the RFNDT relative to the control group. However, those treated with 5.0 mg/kg MPH did take significantly longer to reach criterion performance than those treated with the 3.0 mg/kg MPH, suggesting some doses of MPH can have detrimental effects. For the DSWT, if MPH was present in both phases, performance did not differ from when it was absent in both phases. However, when present in only one phase there was an increase in errors made, although this only reached significance for when MPH was present only in the test-phase. These data suggest that MPH may have detrimental effects on task performance and can result in state dependent effects in healthy individuals.

33 CFR 151.55 - Recordkeeping requirements.

Science.gov (United States)

2010-07-01

... (CONTINUED) POLLUTION VESSELS CARRYING OIL, NOXIOUS LIQUID SUBSTANCES, GARBAGE, MUNICIPAL OR COMMERCIAL WASTE... Antarctic Treaty as it Pertains to Pollution from Ships Garbage Pollution and Sewage § 151.55 Recordkeeping...) Plastic material. (ii) Floating dunnage, lining, or packing material. (iii) Ground paper products, rags...

20 CFR 401.65 - How to correct your record.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false How to correct your record. 401.65 Section 401.65 Employees' Benefits SOCIAL SECURITY ADMINISTRATION PRIVACY AND DISCLOSURE OF OFFICIAL RECORDS... the record of a claim in the administrative appeal process. Disagreements with these determinations...

A 65‑gene signature for prognostic prediction in colon adenocarcinoma.

Science.gov (United States)

Jiang, Hui; Du, Jun; Gu, Jiming; Jin, Liugen; Pu, Yong; Fei, Bojian

2018-04-01

The aim of the present study was to examine the molecular factors associated with the prognosis of colon cancer. Gene expression datasets were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases to screen differentially expressed genes (DEGs) between colon cancer samples and normal samples. Survival‑related genes were selected from the DEGs using the Cox regression method. A co‑expression network of survival‑related genes was then constructed, and functional clusters were extracted from this network. The significantly enriched functions and pathways of the genes in the network were identified. Using Bayesian discriminant analysis, a prognostic prediction system was established to distinguish the positive from negative prognostic samples. The discrimination efficacy of the system was validated in the GSE17538 dataset using Kaplan‑Meier survival analysis. A total of 636 and 1,892 DEGs between the colon cancer samples and normal samples were screened from the TCGA and GSE44861 dataset, respectively. There were 155 survival‑related genes selected. The co‑expression network of survival‑related genes included 138 genes, 534 lines (connections) and five functional clusters, including the signaling pathway, cellular response to cAMP, and immune system process functional clusters. The molecular function, cellular components and biological processes were the significantly enriched functions. The peroxisome proliferator‑activated receptor signaling pathway, Wnt signaling pathway, B cell receptor signaling pathway, and cytokine‑cytokine receptor interactions were the significant pathways. A prognostic prediction system based on a 65‑gene signature was established using this co‑expression network. Its discriminatory effect was validated in the TCGA dataset (P=3.56e‑12) and the GSE17538 dataset (P=1.67e‑6). The 65‑gene signature included kallikrein‑related peptidase 6 (KLK6), collagen type XI α1 (COL11A1), cartilage

Ingo Schwarz zum 65. Geburtstag

Directory of Open Access Journals (Sweden)

Die Mitarbeiterinnen und Mitarbeiter der Alexander-von-Humboldt-Forschungsstelle

2014-12-01

Full Text Available Am 17. Dezember 2014 feiert der langjährige Arbeitsstellenleiter der Alexander-von-Humboldt-Forschungsstelle der Berlin-Brandenburgischen Akademie der Wissenschaften Ingo Schwarz seinen 65. Geburtstag. Aus diesem Anlass haben Freunde, Kollegen und Wegbegleiter Beiträge zusammengetragen, die die Bandbreite der jahrzehntelangen Forschungen Ingo Schwarz’ zu Alexander von Humboldt widerspiegeln.

40 CFR 425.55 - Pretreatment standards for existing sources (PSES).

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Pretreatment standards for existing sources (PSES). 425.55 Section 425.55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS LEATHER TANNING AND FINISHING POINT SOURCE CATEGORY No Beamhouse...

Forced differentiation of CFU-S by iron-55 erythrocytocide

International Nuclear Information System (INIS)

Reincke, U.; Brookoff, D.; Burlington, H.; Cronkite, E.P.; Mount Sinai School of Medicine, New York

1979-01-01

Cascades of Auger electrons are emitted in the decay of 55 Fe and absorbed in tissue within a 1μm radius. Cytocidal amounts of 55 Fe can therefore eliminate erythroid precursors with minimal damage to adjacent cells. A single intravenous injection leads to continued erythrocytocide in mice because the isotope is reutilized and has a 2.7 year half-life. The cytocide evokes an early compensatory response from morphologically unrecognizable precursors which differentiate into pronormoblasts. These early events leave the granuloid series undisturbed but they are accompanied by a precipitous fall in pluripotent stem cell (CFU-S) numbers in bone marrow, spleen, and blood. The pretreatment levels of CFU-S are not restored. Gradual decline of CFU-S is associated with intermittently increased turnover rates and reduced settings of cell production, yet the capacity for quick restoration of blood loss is unimpaired. The precipitous initial stem cell decrease is not caused by irradiation damage, as shown in a separate experimental series that used the frozen-storage cytocide technique. Only over several weeks could 55 Fe radiation accumulate to lethal levels in nondividing stem cells. This irradiation is attributed to incorporation of small amounts of 55 Fe into CFU-S, from where it is slowly cleared. The stem cell loss immediately following 55 Fe injection is in our interpretation caused by rapid differentiation along the erythroid pathway in a response that involves all progenitor populations. Data are consistent with the hypothesis of limited cell renewal capacity which thereby gains further support. (orig.) [de

27 CFR 7.55 - Comparative advertising.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Comparative advertising. 7..., DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF MALT BEVERAGES Advertising of Malt Beverages § 7.55 Comparative advertising. (a) General. Comparative advertising shall not be disparaging of a...

Bioassay techniques for {sup 55}Fe in urine samples

Energy Technology Data Exchange (ETDEWEB)

Cregan, S P; Leon, J W; Linauskas, S H

1993-11-01

Solvent extraction, ion chromatography and several rapid screening methods were developed and evaluated for {sup 55}Fe bioassay applications. Isopropyl ether and TNOA column extractions had radiochemical recoveries exceeding 90%. These were very reproducible with a coefficient of variation less than 5%. Screening techniques investigated included direct counting of ashed urine solids, and Fe(OH){sub 3}. precipitated from urine. The sensitivities (2-50 Bq/d urine) of the screening methods were usually limited by the effective urine volume that could be counted in a liquid scintillation counter. The reference isopropyl ether and chromatography methods could easily achieve sensitivities well below the 1 Bq/d urine output target. (author). 49 refs., 3 tabs., 5 figs.

Determination of iron 55 in nuclear wastes and effluents

International Nuclear Information System (INIS)

Raymond, A.; Revy, D.

1989-01-01

The methods for iron 55 analysis, described in this report allows measurement in different types of radioactive wastes after a specific chemical separation. Detection limit is near 1 Bq/l and the concentration factor can reach 100. Activity level found show that iron 55 is a major activation product, then the chemical determination is indispensable for a complete inventory of radionuclides in radioactive wastes [fr

9 CFR 113.55 - Detection of extraneous agents in Master Seed Virus.

Science.gov (United States)

2010-01-01

... Master Seed Virus. 113.55 Section 113.55 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Ingredient Requirements § 113.55 Detection of extraneous agents in Master Seed Virus...

A review of OROS methylphenidate (Concerta(®)) in the treatment of attention-deficit/hyperactivity disorder.

Science.gov (United States)

Katzman, Martin A; Sternat, Tia

2014-11-01

Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioural disorder with onset during childhood. It affects a child's development, both at home and at school, and impacts on social, emotional and cognitive functioning, in both the home and the school environment. Untreated ADHD is very often associated with poor academic achievement, low occupational status, increased risk of substance abuse and delinquency. Current practice guidelines recommend a multimodal approach in the treatment of ADHD, which includes educational, behavioural and mental health interventions, and pharmacological management. Stimulant medications, including methylphenidate (MPH) and amphetamine products, are recommended as first-line pharmacotherapy in the treatment of ADHD. The choice of stimulant is influenced by several factors; the most influential factor is the duration of action. Long-acting medication provides benefits long after school and work. It also increases the likelihood of once-daily dosing, thereby eliminating the need for mid-day dosing, making the treatment more private, avoiding stigma and improving adherence to medication. MPH is the most widely used psychotropic medication in child psychiatry. It was first developed for use in children as an oral, immediate-release formulation and more recently as various extended-release formulations. These latter formulations include the 12 h preparation Concerta(®) (osmotic-release oral system [OROS] MPH), which utilizes an osmotic pump system, designed to overcome the difficulties of multiple daily dosing. Since it received approval from the US Food and Drug Administration in August 2000, OROS MPH has been quickly and widely accepted as one of the preferred treatments for ADHD because of its once-daily dosing. This paper reviews the data in support of long-acting OROS MPH in children, adolescents and adults, both in ADHD and in association with its comorbidities.

Electrochemical Investigation of the Corrosion of Different Microstructural Phases of X65 Pipeline Steel under Saturated Carbon Dioxide Conditions

Directory of Open Access Journals (Sweden)

Yuanfeng Yang

2015-05-01

Full Text Available The aim of this research was to investigate the influence of metallurgy on the corrosion behaviour of separate weld zone (WZ and parent plate (PP regions of X65 pipeline steel in a solution of deionised water saturated with CO2, at two different temperatures (55 °C and 80 °C and at initial pH~4.0. In addition, a non-electrochemical immersion experiment was also performed at 80 °C in CO2, on a sample portion of X65 pipeline containing part of a weld section, together with adjacent heat affected zones (HAZ and parent material. Electrochemical impedance spectroscopy (EIS was used to evaluate the corrosion behaviour of the separate weld and parent plate samples. This study seeks to understand the significance of the different microstructures within the different zones of the welded X65 pipe in CO2 environments on corrosion performance; with particular attention given to the formation of surface scales; and their composition/significance. The results obtained from grazing incidence X-ray diffraction (GIXRD measurements suggest that, post immersion, the parent plate substrate is scale free, with only features arising from ferrite (α-Fe and cementite (Fe3C apparent. In contrast, at 80 °C, GIXRD from the weld zone substrate, and weld zone/heat affected zone of the non-electrochemical sample indicates the presence of siderite (FeCO3 and chukanovite (Fe2CO3(OH2 phases. Scanning Electron Microscopy (SEM on this surface confirmed the presence of characteristic discrete cube-shaped crystallites of siderite together with plate-like clusters of chukanovite.

GAD65 haplodeficiency conveys resilience in animal models of stress-induced psychopathology

Directory of Open Access Journals (Sweden)

Iris eMüller

2014-08-01

Full Text Available GABAergic mechanisms are critically involved in the control of fear and anxiety, but their role in the development of stress-induced psychopathologies, including post-traumatic stress disorder (PTSD and mood disorders is not sufficiently understood. We studied these functions in two established mouse models of risk factors for stress-induced psychopathologies employing variable juvenile stress and/or social isolation. A battery of emotional tests in adulthood revealed the induction of contextually generalized fear, anxiety, hyperarousal and depression-like symptoms in these paradigms. These reflect the multitude and complexity of stress effects in human PTSD patients. With factor analysis we were able to identify parameters that reflect these different behavioral domains in stressed animals and thus provide a basis for an integrated scoring of affectedness more closely resembling the clinical situation than isolated parameters. To test the applicability of these models to genetic approaches we further tested the role of GABA using heterozygous mice with targeted mutation of the GABA synthesizing enzyme GAD65 (GAD65+/- mice, which show a delayed postnatal increase in tissue GABA content in limbic and cortical brain areas. Unexpectedly, GAD65(+/- mice did not show changes in exploratory activity regardless of the stressor type and were after the variable juvenile stress procedure protected from the development of contextual generalization in an auditory fear conditioning experiment. Our data demonstrate the complex nature of behavioral alterations in rodent models of stress-related psychopathologies and suggest that GAD65 haplodeficiency, likely through its effect on the postnatal maturation of GABAergic transmission, conveys resilience to some of these stress-induced effects.

United States Air Force Academy (USAFA) Vertical Axis Wind Turbine.

Science.gov (United States)

1980-09-01

Rotors, SAND76-0131. Albuquerque: July 1977. 10. Oliver, R.C. and P.R. Nixon. "Design Procedure for Coupling Savonius and Darrieus Wind Turbines ", Air...May 17-20, 1976. -65- 16. Blackwell, B.F., R.E. Sheldahl, and L.V. Feltz. Wind Tunnel Performance Data for the Darrieus Wind Turbine with NACA 0012...a 5.8 m/s (13 mph) wind . At 100 rpm, the Darrieus turbine would be fully self-sustaining and acceleration would continue to an operating tip speed

Assessment of the efficiency of cognitive function of people over 65

Directory of Open Access Journals (Sweden)

Katarzyna Tomaszewska

2018-05-01

Full Text Available Demographic estimates for Poland indicate that the average life expectancy of the population will increase further over the next decades. Weakness of memory is a physiological phenomenon affecting about 60% of people over 65, whereas the prevalence of dementia in the population is estimated at 10-11%. Identification of people at high risk of developing dementia is becoming a significant medical and social problem. Cognitive impairment is one of the first symptoms of dementia. The Mini-Mental State Examination (MMSE is a screening method that allows initial assessment of cognitive performance. Correct diagnosis of symptoms, determining the health needs of seniors in all dimensions sets its further paths and optimal medical treatment. Aim of the paper: The aim of this paper is to assess the efficiency of cognitive function of people over 65. Material and methods: The analysis included 135 questionnaires of the Mini-Mental State Examination (MMSE and respondents’ particulars. Additionally, the functional efficiency of the subjects was assessed using the Barthel scale. The research was conducted among people over 65 in the Podkarpackie Voivodeship in 2017. For the purpose of this work, especially for verification of hypotheses, the following tests were used for questions on nominal scales: V Kramer (2x3, 4x5 tables etc., Phi (2x2 tables. Tb-Kendall or Tc tests were used for questions on ordinal scales. The statistical analysis was carried out using the SPSS program and all relationships were statistically significant when p

Estimation of /sup 65/Zn background levels for marine coastal waters. [Data from northeast Pacific coast for August 1964

Energy Technology Data Exchange (ETDEWEB)

Alexander, G V; Rowland, R H

1966-04-09

Data are presented on Zn and /sup 65/Zn contents in tissues of marine animals collected along the Pacific coast near to and remote from the Columbia River. Specimens of barnacles, starfish, and mussels were collected during August of 1964. Tissues were dried by lyophilization and the radioisotope concentration was determined with a whole-body counter. To evaluate the background contamination level of /sup 65/Zn on the Pacific coast, /sup 54/Mn analyses were included to differentiate the contribution of fallout and /sup 51/Cr was determined to evaluate the contribution from the Columbia River. It was concluded that coastal /sup 65/Zn levels result essentially from fallout and that the present level in fallout is relatively constant at 0.05 to 2.7 pc /sup 65/Zn/mg Zn.

Prospective validation of criteria, including age, for safe, nonsurgical management of the ruptured spleen

Energy Technology Data Exchange (ETDEWEB)

Smith, J.S. Jr.; Wengrovitz, M.A.; DeLong, B.S. (Pennsylvania State University College of Medicine, Hershey (United States))

1992-09-01

One hundred twelve cases of blunt splenic rupture were prospectively entered (October 1987-October 1991) into surgical or nonsurgical management groups using these criteria for the nonsurgical group: hemodynamic stability-age less than 55 years-CT scan appearance of grade I, II, or III injury-absence of concomitant injuries precluding abdominal assessment+absence of other documented abdominal injuries. All ages were included and AAST injury scaling was used. Patients were grouped from the trauma room. The surgical treatment group included 66 patients (49 splenectomies, 17 splenorraphies). These patients were generally older and more severely injured, required more transfused blood, and a longer ICU stay. The nonsurgical group included 46 patients with 33 older than 14 years. There were 3 patients over the age of 55 years inappropriately included in this group, and nonsurgical therapy failed in all three. Statistical analysis (chi 2) showed that more splenic injuries were observed and more spleens were saved with these criteria applied prospectively compared with a previous retrospective series in the same institution. The series had a success rate of 93%, and validates the criteria used for safe, nonsurgical management of the ruptured spleen and adds a new criterion: a maximum age of 55 years.

Prospective validation of criteria, including age, for safe, nonsurgical management of the ruptured spleen

International Nuclear Information System (INIS)

Smith, J.S. Jr.; Wengrovitz, M.A.; DeLong, B.S.

1992-01-01

One hundred twelve cases of blunt splenic rupture were prospectively entered (October 1987-October 1991) into surgical or nonsurgical management groups using these criteria for the nonsurgical group: hemodynamic stability-age less than 55 years-CT scan appearance of grade I, II, or III injury-absence of concomitant injuries precluding abdominal assessment+absence of other documented abdominal injuries. All ages were included and AAST injury scaling was used. Patients were grouped from the trauma room. The surgical treatment group included 66 patients (49 splenectomies, 17 splenorraphies). These patients were generally older and more severely injured, required more transfused blood, and a longer ICU stay. The nonsurgical group included 46 patients with 33 older than 14 years. There were 3 patients over the age of 55 years inappropriately included in this group, and nonsurgical therapy failed in all three. Statistical analysis (chi 2) showed that more splenic injuries were observed and more spleens were saved with these criteria applied prospectively compared with a previous retrospective series in the same institution. The series had a success rate of 93%, and validates the criteria used for safe, nonsurgical management of the ruptured spleen and adds a new criterion: a maximum age of 55 years

The baby boomer effect: changing patterns of substance abuse among adults ages 55 and older.

Science.gov (United States)

Duncan, David F; Nicholson, Thomas; White, John B; Bradley, Dana Burr; Bonaguro, John

2010-07-01

Between now and 2030, the number of adults aged 65 and older in the United States will almost double, from around 37 million to more than 70 million, an increase from 12% of the U.S. population to almost 20%. It was long held that, with only a few isolated exceptions, substance abuse simply did not exist among this population. In light of the impact of the baby boom generation, this assumption may no longer be valid. The authors examined admissions of persons 55 years and older (n = 918,955) from the Treatment Episode Data Set (1998-2006). Total admissions with a primary drug problem with alcohol have remained relatively stable over this time. Admissions for problems with a primary drug other than alcohol have shown a steady and substantial increase. Clearly, data from the Treatment Episode Data Set indicate a coming wave of older addicts whose primary problem is not alcohol. The authors suspect that this wave is led primarily by the continuing emergence of the baby boomer generation.

10 CFR 74.55 - Item monitoring.

Science.gov (United States)

2010-01-01

... Quantities of Strategic Special Nuclear Material § 74.55 Item monitoring. (a) Licensees subject to § 74.51... quantitatively measured, the validity of that measurement independently confirmed, and that additionally have..., except for reactor components measuring at least one meter in length and weighing in excess of 30...

49 CFR 1242.80 - Fringe benefits (account 12-55-00).

Science.gov (United States)

2010-10-01

... 49 Transportation 9 2010-10-01 2010-10-01 false Fringe benefits (account 12-55-00). 1242.80 Section 1242.80 Transportation Other Regulations Relating to Transportation (Continued) SURFACE...-Transportation § 1242.80 Fringe benefits (account 12-55-00). Separate common expenses in proportion to the...

Comparison of two-stage thermophilic (68 degrees C/55 degrees C) anaerobic digestion with one-stage thermophilic (55 degrees C) digestion of cattle manure.

Science.gov (United States)

Nielsen, H B; Mladenovska, Z; Westermann, P; Ahring, B K

2004-05-05

A two-stage 68 degrees C/55 degrees C anaerobic degradation process for treatment of cattle manure was studied. In batch experiments, an increase of the specific methane yield, ranging from 24% to 56%, was obtained when cattle manure and its fractions (fibers and liquid) were pretreated at 68 degrees C for periods of 36, 108, and 168 h, and subsequently digested at 55 degrees C. In a lab-scale experiment, the performance of a two-stage reactor system, consisting of a digester operating at 68 degrees C with a hydraulic retention time (HRT) of 3 days, connected to a 55 degrees C reactor with 12-day HRT, was compared with a conventional single-stage reactor running at 55 degrees C with 15-days HRT. When an organic loading of 3 g volatile solids (VS) per liter per day was applied, the two-stage setup had a 6% to 8% higher specific methane yield and a 9% more effective VS-removal than the conventional single-stage reactor. The 68 degrees C reactor generated 7% to 9% of the total amount of methane of the two-stage system and maintained a volatile fatty acids (VFA) concentration of 4.0 to 4.4 g acetate per liter. Population size and activity of aceticlastic methanogens, syntrophic bacteria, and hydrolytic/fermentative bacteria were significantly lower in the 68 degrees C reactor than in the 55 degrees C reactors. The density levels of methanogens utilizing H2/CO2 or formate were, however, in the same range for all reactors, although the degradation of these substrates was significantly lower in the 68 degrees C reactor than in the 55 degrees C reactors. Temporal temperature gradient electrophoresis profiles (TTGE) of the 68 degrees C reactor demonstrated a stable bacterial community along with a less divergent community of archaeal species. Copyright 2004 Wiley Periodicals, Inc.

36 CFR 212.55 - Criteria for designation of roads, trails, and areas.

Science.gov (United States)

2010-07-01

... roads, trails, and areas. 212.55 Section 212.55 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE TRAVEL MANAGEMENT Designation of Roads, Trails, and Areas for Motor Vehicle Use § 212.55 Criteria for designation of roads, trails, and areas. (a) General criteria for designation of...

Issues for reuse of gloveboxes at LANL TA-55

Energy Technology Data Exchange (ETDEWEB)

Cadwallader, L.C.; Pinson, P.A.; Miller, C.F.

1998-08-01

This report is a summary of issues that face plutonium glovebox designers and users at the Los Alamos National Laboratory (LANL) Technical Area 55 (TA-55). Characterizing the issues is a step in the task of enhancing the next generation glovebox design to minimize waste streams while providing the other design functions. This report gives an initial assessment of eight important design and operation issues that can benefit from waste minimization.

Issues for reuse of gloveboxes at LANL TA-55

International Nuclear Information System (INIS)

Cadwallader, L.C.; Pinson, P.A.; Miller, C.F.

1998-08-01

This report is a summary of issues that face plutonium glovebox designers and users at the Los Alamos National Laboratory (LANL) Technical Area 55 (TA-55). Characterizing the issues is a step in the task of enhancing the next generation glovebox design to minimize waste streams while providing the other design functions. This report gives an initial assessment of eight important design and operation issues that can benefit from waste minimization

40 CFR 65.145 - Nonflare control devices used to control emissions from storage vessels or low-throughput...

Science.gov (United States)

2010-07-01

... included. (E) For condensers, the design evaluation shall include the final temperature of the stream vapors, the type of condenser, and the design flow rate of the emission stream. (ii) Performance test. A... startup, shutdown, and malfunction as specified in § 65.3(a). (b) Nonflare control device design...

Waste streams that preferentially corrode 55-gallon steel storage drums

International Nuclear Information System (INIS)

Zirker, L.R.; Beitel, G.A.; Reece, C.M.

1995-06-01

When 55-gal steel drum waste containers fail in service, i.e., leak, corrode or breach, the standard fix has been to overpack the drum. When a drum fails and is overpacked into an 83-gal overpack drum, there are several negative consequences. Identifying waste streams that preferentially corrode steel drums is essential to the pollution prevention philosophy that ''an ounce of prevention is worth a pound of cure.'' It is essential that facilities perform pollution prevention measures at the front end of processes to reduce pollution on the back end. If these waste streams can be identified before they are packaged, the initial drum packaging system could be fortified or increased to eliminate future drum failures, breaches, clean-ups, and the plethora of other consequences. Therefore, a survey was conducted throughout the US Department of Energy complex for information concerning waste streams that have demonstrated preferential corrosion of 55-gal steel drums. From 21 site contacts, 21 waste streams were so identified. The major components of these waste streams include acids, salts, and solvent liquids, sludges, and still bottoms. The solvent-based waste streams typically had the shortest time to failure, 0.5 to 2 years. This report provides the results of this survey and research

Pattern of Coronary Artery Disease Risk Factors in Population Younger than 55 Years and Above 55 Years: A Population Study of 31999 Healthy Individuals

Directory of Open Access Journals (Sweden)

Zinat Nadia Hatmi

2011-06-01

Full Text Available More than eighty percent of patients with coronary heart diseases (CHD have conventional risk factors. Prevalence of well known risk factors seems to show a different pattern in younger patients and individual above 55 years. To evaluate the pattern of conventional CHD risk factors in healthy individuals in two different age groups. A large scale population based survey of 31999 individuals from ten medical centers was designed. Screening of risk factors was performed upon these protocols: taking medical history, physical examination and blood tests of complete blood cell counts, fasting blood sugar, lipid profile, urinalysis and creatinine. Prevalence of the risk factors in healthy people aged above 55 years were: 8.1% for systolic blood pressure (SBP>140 mmHg, 3.8% for diastolic blood pressure (DBP>90mmHg, 13.9% for fasting blood glucose (FBS≥126 Mg/dl, 36.9% for total cholesterol>200 Mg/dl, 19.2% for triglyceride (TG>200 Mg/dl, 67.8% for HDL-c130 Mg/dl, 4.72 for TC/HDL-c ratio, 2.88 for LDL-c/HDL/c ratio and 4.24 for TG/HDL-c ratio. Prevalence of risk factors in individuals younger than 55 years were: 1.7% for SBP>140 mmHg, 1.2% for DBP>90 mmHg, 5.2% for FBS≥126 Mg/dl, 31.3% for TC>200 Mg/dl, 21.5% for TG>200 Mg/dl, 69.4% for HDL-c130 Mg/dl, 4.7 for TC/HDL-c ratio, 2.83 for LDL-c/HDL-c ratio and 4.43 for TG/HDL-c ratio. In univariate model of analysis: prevalence of the risk factors were significantly higher in age above 55 years than in people younger than 55 years except for hypertriglyceridemia and HDL-c200 Mg/dl P= 0.002, HDL-c140 mmHg P=0.001. Pattern of such a CHD risk factors of FBS≥126 Mg/dl, TG>200 Mg/dl, HDL-c140 mmHg demonstrated a statistically significant difference in the age above 55 years to the healthy people younger than 55 years. These results cab be implicated to set up prediction models for stratifying individuals at higher risk of CHD.

Mapping Dual-Degree Programs in Social Work and Public Health: Results From a National Survey

Directory of Open Access Journals (Sweden)

Dory Ziperstein

2016-02-01

Full Text Available Dramatic changes in the health system due to national health reform are raising important questions regarding the educational preparation of social workers for the new health arena. While dual-degree programs in public health and social work can be an important response to what is needed educationally, little is known about them. The National MSW/MPH Programs Study surveyed MSW/MPH program administrators to better understand the prevalence, models, structure, and challenges of these dual-degree programs. Forty-two programs were identified, and 97.6% of those contacted participated (n=41. Findings indicate that MSW/MPH programs are popular, increasing, geographically dispersed, and drawing talented students interested in trans-disciplinary public health social work practice. Challenges for these programs include the need for greater institutional support, particularly funding, and a general lack of best practices for MSW/MPH education. While findings from this study suggest graduates appear especially well-prepared for leadership and practice in the new health environment, additional research is needed to assess their particular contributions and career trajectories.

Compliance with the CURB-65 score and the consequences of non-implementation.

Science.gov (United States)

Guo, Q; Li, H-Y; Zhou, Y-P; Li, M; Chen, X-K; Liu, H; Peng, H-L; Yu, H-Q; Chen, X; Liu, N; Liang, L-H; Zhao, Q-Z; Jiang, M

2011-12-01

The CURB-65 (confusion, urea >7 mmol/l, respiratory rate ≥ 30 breaths/min, low blood pressure and age ≥ 65 years) score is a simple, well-validated tool for the assessment of severity in community-acquired pneumonia (CAP). It is unknown whether it is used routinely in China. To determine the frequency of use of the CURB-65 score in routine hospital practice and the consequences of non-implementation. A retrospective analysis of medical records from 1230 in-patients with CAP in a Chinese medical college-affiliated hospital. No CAP patient underwent the CURB-65 test at admission. Based on the British Thoracic Society guidelines, the 716 (58.2%) in-patients with a CURB65 score of 0 and the 402 (32.7%) in-patients with CURB-65 score of 1 should have received ambulatory treatment, whereas the 14 (1.2%) patients with CURB65 scores of ≥ 3 should have been admitted to the critical care unit. The maximum excess total annual costs for managing CAP patients with CURB-65 scores of 0 and 1 were estimated at respectively US$94 383.12 and US$66 313.92 in the hospital. The CURB-65 scoring tool in patients with CAP was not applied in routine hospital practice, resulting in inappropriate hospitalisation and excess costs.

#WaysToRelax: developing an online alcohol-related health promotion animation for people aged 55 and older.

Science.gov (United States)

Ferguson, Nyssa; Savic, Michael; Manning, Victoria; Lubman, Daniel

2017-04-27

Alcohol use among middle-aged and older adults (55 years and older) is increasingly becoming a public health concern. Despite this, there is relatively little research on the experiences of alcohol use and related concerns among people aged 55 and older to inform tailored and engaging health promotion activities. To address this gap, we aimed to develop an engaging alcohol-related health promotion resource for people aged 55 and older. We drew on a research-into-action approach, which involved: 1) thematic analysis of alcohol-related concerns in online counselling transcripts of 70 people aged 55 and older, 2) a review of health promotion literature, and 3) consultation with consumers of alcohol and other drug services, and carers. The research phase highlighted that people aged 55 and older were concerned that their reliance on alcohol use to manage stress had become a habit they wanted to shift. Alongside this, the literature showed that people aged 55 and older were often dismissive of conventional health promotion activities, and pointed to the benefits of conveying health promotion messages through animation. In response, we developed an animation to stimulate reflection and thought about other ways to relax and manage stress. We drew on health promotion principles to ensure that the animation had a positive message and was engaging without being ageist or paternalistic. It was further refined with input from consumers and carers, who thought the animation was appropriate, appealing and useful. Future activities will include further dissemination and evaluation of the animation and associated activities.

#WaysToRelax: developing an online alcohol-related health promotion animation for people aged 55 and older

Directory of Open Access Journals (Sweden)

Nyssa Ferguson

2017-04-01

Full Text Available Alcohol use among middle-aged and older adults (55 years and older is increasingly becoming a public health concern. Despite this, there is relatively little research on the experiences of alcohol use and related concerns among people aged 55 and older to inform tailored and engaging health promotion activities. To address this gap, we aimed to develop an engaging alcohol-related health promotion resource for people aged 55 and older. We drew on a research-into-action approach, which involved: 1 thematic analysis of alcohol-related concerns in online counselling transcripts of 70 people aged 55 and older, 2 a review of health promotion literature, and 3 consultation with consumers of alcohol and other drug services, and carers. The research phase highlighted that people aged 55 and older were concerned that their reliance on alcohol use to manage stress had become a habit they wanted to shift. Alongside this, the literature showed that people aged 55 and older were often dismissive of conventional health promotion activities, and pointed to the benefits of conveying health promotion messages through animation. In response, we developed an animation to stimulate reflection and thought about other ways to relax and manage stress. We drew on health promotion principles to ensure that the animation had a positive message and was engaging without being ageist or paternalistic. It was further refined with input from consumers and carers, who thought the animation was appropriate, appealing and useful. Future activities will include further dissemination and evaluation of the animation and associated activities.

Foliar Absorption, Translocation and Utilization of Zn-65 by Mango Seedlings

International Nuclear Information System (INIS)

Mohamed, F.A.; Sharaf, A.N.M.; Awad, S.M.; Abu EL Azm, S.K.

2001-01-01

Greenhouse experiment was designed using ZnSO 4 at rates of 0.125,0.25 and 0.50%. Solutions were adjusted to ph 6.0 and Tween-20 was added as a surfactant. The prepared solutions were labelled with carrier-free Zn-65. Six-month old mango seedlings were arranged in a complete block design to study the foliar absorption,translocation and percentage use of Zn-65 as influenced by soil application of phosphorus. The total absorption of Zn-65 by mango leaves was affected by spraying treatment of Zn-65 and soil application of phosphorus. In this respect increasing the rates of labelled Zn solution resulted in a great increment in the total absorption of in total absorption of Zn-65 by mango leaves was observed due to increasing P rates as a soil application from 0.0 up to 100 ppm. Translocation of the absorbed Zn-65 either in upward or downward direction was positively related to the absorbed amount. The percentage use of Zn-65 by mango leaves was reduced by increasing foliar Zn rates. On the contrary, it was slightly increased as a result of increasing soil application rate of P. Generally, the percentage use of Zn-65 mango leaves was ranged between 8.7 and 16.87 under the conditions of this experiment. Therefore, foliar application of ZnSO 4 could be recommended as a good source of Zn for mango nutrition in particular with addition of high rates of phosphorus as a soil application

Formable ferrite-degenerated pearlite steel (FDP-55) for automotive use

International Nuclear Information System (INIS)

Nagao, N.; Hamamatsu, S.; Kunishige, K.

1984-01-01

In order to help the gauge reduction of wheels and chassis parts of automobiles, a formable and weldable hot rolled steel of 550 MPa grade, named FDP-55, has been developed. FDP-55 is an 0.14% C, 0.1% Si, 1.1% Mn and Nb free Alkilled steel obtained by controlled-cooling to a low coiling temperature on a runout table, and it is featured by ferrite-degenerated pearlite microstructure. Results of co-operative works with automotive makers showed that FDP-55 was successful in the application to wheels and chassis parts attaining the large weight reduction. This paper reports the metallurgical features and characteristics of the steel

7 CFR 319.55-5 - Notice of arrival by permittee.

Science.gov (United States)

2010-01-01

... arrival, the permittee or his agent shall submit a notice, in duplicate, to the Plant Protection and... 7 Agriculture 5 2010-01-01 2010-01-01 false Notice of arrival by permittee. 319.55-5 Section 319.55-5 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH...

Evaluation of the neutron and gamma-ray production cross-sections for 55Mn

International Nuclear Information System (INIS)

Takahashi, H.

1974-11-01

The evaluation of neutron and gamma production cross sections for manganese-55 from 1.0 (10) -5 eV to 20.0 MeV for ENDF/ B-IV is summarized. Included are resonance parameters, neutron cross sections, angular and energy distribution of secondary neutrons, gamma multiplicities and transition probability array, gamma angular and energy distributions, nuclear model calculations, uncertainty estimates of cross sections, and evaluated cross sections. (U.S.)

LARGE SCALE PRODUCTION, PURIFICATION, AND 65CU SOLID STATE NMR OF AZURIN

Energy Technology Data Exchange (ETDEWEB)

Gao, A.; Heck, R.W.

2008-01-01

This paper details a way to produce azurin with an effi ciency over 10 times greater than previously described and demonstrates the fi rst solid state nuclear magnetic resonance spectrum of 65Cu(I) in a metalloprotein. A synthetic gene for azurin based upon the DNA sequence from Pseudomonas aeruginosa including the periplasmic targeting sequence was subcloned into a T7 overexpression vector to create the plasmid pGS-azurin, which was transformed into BL21 (DE3) competent cells. The leader sequence on the expressed protein causes it to be exported to the periplasmic space of Escherichia coli. Bacteria grown in a fermentation unit were induced to overexpress the azurin, which was subsequently purifi ed through an endosmotic shock procedure followed by high performance liquid chromatography (HPLC). 1,500 mg of azurin were purifi ed per liter of culture. 65Cu(II) was added to apo-azurin and then reduced. The 65Cu metal cofactor in azurin was observed with solid state nuclear magnetic resonance (NMR) to determine any structural variations that accompanied copper reduction. This is the fi rst solid state NMR spectra of a copper(I) metalloprotein. Analysis of the NMR spectra is being used to complement hypotheses set forth by x-ray diffraction and computational calculations of electron transfer mechanisms in azurin.

Prescription Stimulants and the Development of Post-Traumatic Stress Disorder among U.S. Service Members

Science.gov (United States)

2013-08-13

Medina-Torne, M.P.H.; Anna Nagel, M.P.H.; Roy Nesbitt, M.A.; Christopher Phillips, M.D., M.P.H.; Roy Nesbitt, M.A.; Toni Rush, M.P.H.; Kari Sausedo...RJ, Robbins BW, Caiola E, Joynt M, Halterman JS. Prescribing of controlled medications to adolescents and young adults in the United States

24 CFR 55.12 - Inapplicability of 24 CFR part 55 to certain categories of proposed actions.

Science.gov (United States)

2010-04-01

... proposed actions. (a) The decision making steps in § 55.20 (b), (c) and (g) (steps 2, 3 and 7) shall not... the footprint of the structure and paved areas is not significantly increased. (b) The decision making...'s actions under section 223(f) of the National Housing Act (12 U.S.C. 1715n(f)) for the purchase or...

Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.

Science.gov (United States)

Chang, Yang; Tesco, Giuseppina; Jeong, William J; Lindsley, Loren; Eckman, Elizabeth A; Eckman, Christopher B; Tanzi, Rudolph E; Guénette, Suzanne Y

2003-12-19

Members of the FE65 family of adaptor proteins, FE65, FE65L1, and FE65L2, bind the C-terminal region of the amyloid precursor protein (APP). Overexpression of FE65 and FE65L1 was previously reported to increase the levels of alpha-secretase-derived APP (APPs alpha). Increased beta-amyloid (A beta) generation was also observed in cells showing the FE65-dependent increase in APPs alpha. To understand the mechanism for the observed increase in both A beta and APPs alpha given that alpha-secretase cleavage of a single APP molecule precludes A beta generation, we examined the effects of FE65L1 overexpression on APP C-terminal fragments (APP CTFs). Our data show that FE65L1 potentiates gamma-secretase processing of APP CTFs, including the amyloidogenic CTF C99, accounting for the ability of FE65L1 to increase generation of APP C-terminal domain and A beta 40. The FE65L1 modulation of these processing events requires binding of FE65L1 to APP and APP CTFs and is not because of a direct effect on gamma-secretase activity, because Notch intracellular domain generation is not altered by FE65L1. Furthermore, enhanced APP CTF processing can be detected in early endosome vesicles but not in endoplasmic reticulum or Golgi membranes, suggesting that the effects of FE65L1 occur at or near the plasma membrane. Finally, although FE65L1 increases APP C-terminal domain production, it does not mediate the APP-dependent transcriptional activation observed with FE65.

Alcohol, tabaco y deterioro cognoscitivo en adultos mexicanos mayores de 65 años Cognitive impairment and alcohol and cigarette consumption in Mexican adults older than 65 years

Directory of Open Access Journals (Sweden)

Sara Gloria Aguilar-Navarro

2007-01-01

Full Text Available OBJETIVO: Conocer la prevalencia del consumo de alcohol y tabaco y su asociación con deterioro cognoscitivo en la población mexicana mayor de 65 años. MATERIAL Y MÉTODOS: Se incluyeron 4 872 mayores de 65 años en la muestra del Estudio Nacional sobre Salud y Envejecimiento en México (ENASEM 2001. Se interrogó sobre el consumo de alcohol y tabaco. Para la clasificación de los sujetos con deterioro cognoscitivo, se utilizó la escala total de los diferentes dominios cognoscitivos. Se aplicaron ji cuadrada, Mann Whitney U y regresión logística para encontrar asociaciones. RESULTADOS: La prevalencia de alcoholismo según CAGE fue de 2.8% y la del consumo de tabaco de 14 por ciento. Factores asociados con el consumo de alcohol: edad 65-69 años (p OBJECTIVE: To determine the prevalence of the consumption of alcohol and cigarette smoking and their association with cognitive impairment among older Mexican adults. MATERIAL AND METHODS: A total of 4 872 people over 65 years of age included in the sample of the National Mexican Health and Aging Study carried out in 2001 were questioned about their consumption of alcohol and cigarette smoking. For the classification of those subjects with cognitive impairment, the total scale of the different cognitive domains was used. The chi-square, Mann-Whitney U test, and logistical regression were used in order to find associations. RESULTS: The prevalence of alcoholism according to CAGE was 2.8% and the prevalence of the consumption of cigarette smoking was 14%. Factors associated with the consumption of alcohol were:age 65-69 (p <0.001, men (RR 3.17,p <0.001, and high level of education (p <0.001. The association between the consumption of alcohol and cognitive impairment (X2=6.59, p <0.01 was statistically significant. CONCLUSIONS: The prevalence of consumption of alcohol and cigarette smoking in older Mexican adults are similar to that reported in other countries; the consumption of alcohol and its

10 CFR 55.25 - Incapacitation because of disability or illness.

Science.gov (United States)

2010-01-01

... § 55.25 Incapacitation because of disability or illness. If, during the term of the license, the licensee develops a permanent physical or mental condition that causes the licensee to fail to meet the... 10 Energy 2 2010-01-01 2010-01-01 false Incapacitation because of disability or illness. 55.25...

46 CFR 78.47-55 - Instructions for changing steering gear.

Science.gov (United States)

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Instructions for changing steering gear. 78.47-55... OPERATIONS Markings for Fire and Emergency Equipment, Etc. § 78.47-55 Instructions for changing steering gear..., relating in order, the different steps to be taken in changing to the emergency steering gear. Each clutch...

7 CFR 1714.55 - Advance of funds from insured loans.

Science.gov (United States)

2010-01-01

... equivalent. Funds will not be advanced until the Administrator has received satisfactory evidence that the... 7 Agriculture 11 2010-01-01 2010-01-01 false Advance of funds from insured loans. 1714.55 Section... § 1714.55 Advance of funds from insured loans. The borrower shall request advances of funds as needed...

Intrinsic labeling of alpha-fetoprotein with 65Zn

International Nuclear Information System (INIS)

Preiss, I.L.

1994-01-01

Many enzymes, proteins, and large molecules bind a variety of inorganic ions. The replacement of a specific metal ion with another element can disrupt the biodistribution and biochemistry of the host molecule. Alpha-fetoprotein (AFP) is a known oncofetal antigen. The authors have demonstrated that the substitution of Cu or Pb on AFP inhibits the transplacental migration of AFP and may lead to fetal demise. It is evident that in labeling with a radiotracer in order to observe the true distribution of a molecule, one must select a radioisotope of an element which is naturally bound to the host molecule. It has been demonstrated that AFP binds Zn in vivo. Thus, substituting 65 Zn for natural Zn produces an intrinsic label for AFP. The authors discuss the methodology for stripping and labeling of AFP with 65 Zn. The biodistribution of labeled AFP is compared with that of 65 Zn 2+ in healthy and diseased (hepatoma) animals

50 CFR 25.55 - Refuge admission permits.

Science.gov (United States)

2010-10-01

...-specific permits, at Fish and Wildlife Service Regional and Washington, DC Offices, and at other locations....55 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR... the holder on the front. ...

Heterologous expression in Tritrichomonas foetus of functional Trichomonas vaginalis AP65 adhesin

Directory of Open Access Journals (Sweden)

Alderete JF

2005-03-01

Full Text Available Abstract Background Trichomonosis, caused by Trichomonas vaginalis, is the number one, nonviral sexually transmitted infection that has adverse consequences for the health of women and children. The interaction of T. vaginalis with vaginal epithelial cells (VECs, a step preparatory to infection, is mediated in part by the prominent surface protein AP65. The bovine trichomonad, Tritrichomonas foetus, adheres poorly to human VECs. Thus, we established a transfection system for heterologous expression of the T. vaginalis AP65 in T. foetus, as an alternative approach to confirm adhesin function for this virulence factor. Results In this study, we show stable transfection and expression of the T. vaginalis ap65 gene in T. foetus from an episomal pBS-ap65-neo plasmid. Expression of the gene and protein was confirmed by RT-PCR and immunoblots, respectively. AP65 in transformed T. foetus bound to host cells. Specific mAbs revealed episomally-expressed AP65 targeted to the parasite surface and hydrogenosome organelles. Importantly, surface-expression of AP65 in T. foetus paralleled increased levels of adherence of transfected bovine trichomonads to human VECs. Conclusion The T. vaginalis AP65 adhesin was stably expressed in T. foetus, and the data obtained using this heterologous system strongly supports the role of AP65 as a prominent adhesin for T. vaginalis. In addition, the heterologous expression in T. foetus of a T. vaginalis gene offers an important, new approach for confirming and characterizing virulence factors.

A Case for an Atmosphere on Super-Earth 55 Cancri e

Science.gov (United States)

Angelo, Isabel; Hu, Renyu

2017-12-01

One of the primary questions when characterizing Earth-sized and super-Earth-sized exoplanets is whether they have a substantial atmosphere like Earth and Venus or a bare-rock surface like Mercury. Phase curves of the planets in thermal emission provide clues to this question, because a substantial atmosphere would transport heat more efficiently than a bare-rock surface. Analyzing phase-curve photometric data around secondary eclipses has previously been used to study energy transport in the atmospheres of hot Jupiters. Here we use phase curve, Spitzer time-series photometry to study the thermal emission properties of the super-Earth exoplanet 55 Cancri e. We utilize a semianalytical framework to fit a physical model to the infrared photometric data at 4.5 μm. The model uses parameters of planetary properties including Bond albedo, heat redistribution efficiency (I.e., ratio between radiative timescale and advective timescale of the atmosphere), and the atmospheric greenhouse factor. The phase curve of 55 Cancri e is dominated by thermal emission with an eastward-shifted hotspot. We determine the heat redistribution efficiency to be {1.47}-0.25+0.30, which implies that the advective timescale is on the same order as the radiative timescale. This requirement cannot be met by the bare-rock planet scenario because heat transport by currents of molten lava would be too slow. The phase curve thus favors the scenario with a substantial atmosphere. Our constraints on the heat redistribution efficiency translate to an atmospheric pressure of ˜1.4 bar. The Spitzer 4.5 μm band is thus a window into the deep atmosphere of the planet 55 Cancri e.

A Treatment Program for Failure to Thrive: A Cost-Effectiveness Analysis.

Science.gov (United States)

Karniski, Walt; And Others

1986-01-01

Analysis of treatment of infants suffering from Failure to Thrive placed in foster medical placement homes (MPH, N=17) or admitted to hospitals (N=18) revealed that the MPH infants grew more than hospitalized infants and parents of MPH children had advantages of education and support. The MPH program cost less than 25 percent of hospital care.…

Predictors of low self-rated health in patients aged 65+ after total hip replacement (THA)

DEFF Research Database (Denmark)

Hørdam, Britta; Hemmingsen, Lars

2013-01-01

predicting low self-rated health after surgery. Material and method: A cross-sectional study including 287 patients aged 65+, who had had THR within 12-months were performed. Patients from five Danish counties received a mailed questionnaire assessing health status and demographic data. Short Form-36...

Norepinephrine genes predict response time variability and methylphenidate-induced changes in neuropsychological function in attention deficit hyperactivity disorder.

Science.gov (United States)

Kim, Bung-Nyun; Kim, Jae-Won; Cummins, Tarrant D R; Bellgrove, Mark A; Hawi, Ziarih; Hong, Soon-Beom; Yang, Young-Hui; Kim, Hyo-Jin; Shin, Min-Sup; Cho, Soo-Churl; Kim, Ji-Hoon; Son, Jung-Woo; Shin, Yun-Mi; Chung, Un-Sun; Han, Doug-Hyun

2013-06-01

Noradrenergic dysfunction may be associated with cognitive impairments in attention-deficit/hyperactivity disorder (ADHD), including increased response time variability, which has been proposed as a leading endophenotype for ADHD. The aim of this study was to examine the relationship between polymorphisms in the α-2A-adrenergic receptor (ADRA2A) and norepinephrine transporter (SLC6A2) genes and attentional performance in ADHD children before and after pharmacological treatment.One hundred one medication-naive ADHD children were included. All subjects were administered methylphenidate (MPH)-OROS for 12 weeks. The subjects underwent a computerized comprehensive attention test to measure the response time variability at baseline before MPH treatment and after 12 weeks. Additive regression analyses controlling for ADHD symptom severity, age, sex, IQ, and final dose of MPH examined the association between response time variability on the comprehensive attention test measures and allelic variations in single-nucleotide polymorphisms of the ADRA2A and SLC6A2 before and after MPH treatment.Increasing possession of an A allele at the G1287A polymorphism of SLC6A2 was significantly related to heightened response time variability at baseline in the sustained (P = 2.0 × 10) and auditory selective attention (P = 1.0 × 10) tasks. Response time variability at baseline increased additively with possession of the T allele at the DraI polymorphism of the ADRA2A gene in the auditory selective attention task (P = 2.0 × 10). After medication, increasing possession of a G allele at the MspI polymorphism of the ADRA2A gene was associated with increased MPH-related change in response time variability in the flanker task (P = 1.0 × 10).Our study suggested an association between norepinephrine gene variants and response time variability measured at baseline and after MPH treatment in children with ADHD. Our results add to a growing body of evidence, suggesting that response time

Endometriosis in Adolescent and Young Girls: Report on a Series of 55 Cases.

Science.gov (United States)

Matalliotakis, Michail; Goulielmos, George N; Matalliotaki, Charoula; Trivli, Alexandra; Matalliotakis, Ioannis; Arici, Aydin

2017-10-01

The aim of this retrospective study was to evaluate endometriosis in adolescent and young girls and further to review the menstrual, reproductive characteristics, and risk factors. We reviewed the medical records of adolescent and young girls with endometriosis from 2 different countries. Data were collected and analyzed from charts of 900 patients with endometriosis. Fifty-five female adolescents aged between 13 and 21 years (mean age 18.3 years) participated in our series. This study was conducted in the Obstetric and Gynecology Department of Venizeleio General Hospital of Crete and involved all patients diagnosed with endometriosis between 1996 and 2016. Statistical methods included χ 2 and Mann-Whitney U test. Of 900 patients with endometriosis we found 55 female adolescents (6.1%). The mean age was 18.3 ± 2.3 years, significantly younger compared with the advanced endometriosis patients (32.7 ± 7.2; P endometriosis group. The factors associated with an increased risk for young women include age at menarche, dysmenorrhea, history of asthma, and a positive family history of endometriosis. Additionally, we report on 16 of 55 (32%) adolescent women with endometriosis and congenital malformations (P endometriosis in adolescent and young women and risk factors including early menarche, early onset of dysmenorrhea, history of asthma, previous surgical procedures, obstructive genital anomalies, and family history of endometriosis. Copyright © 2017 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

ExploreNEOs. III. PHYSICAL CHARACTERIZATION OF 65 POTENTIAL SPACECRAFT TARGET ASTEROIDS

International Nuclear Information System (INIS)

Mueller, Michael; Delbo', M.; Hora, J. L.; Fazio, G.; Smith, H. A.; Spahr, T. B.; Trilling, D. E.; Thomas, C. A.; Bhattacharya, B.; Bottke, W. F.; Chesley, S.; Mainzer, A.; Emery, J. P.; Harris, A. W.; Mommert, M.; Penprase, B.; Stansberry, J. A.

2011-01-01

Space missions to near-Earth objects (NEOs) are being planned at all major space agencies, and recently a manned mission to an NEO was announced as a NASA goal. Efforts to find and select suitable targets (plus backup targets) are severely hampered by our lack of knowledge of the physical properties of dynamically favorable NEOs. In particular, current mission scenarios tend to favor primitive low-albedo objects. For the vast majority of NEOs, the albedo is unknown. Here we report new constraints on the size and albedo of 65 NEOs with rendezvous Δv -1 . Our results are based on thermal-IR flux data obtained in the framework of our ongoing (2009-2011) ExploreNEOs survey using NASA's 'Warm-Spitzer' space telescope. As of 2010 July 14, we have results for 293 objects in hand (including the 65 low-Δv NEOs presented here); before the end of 2011, we expect to have measured the size and albedo of ∼700 NEOs (including probably ∼160 low-Δv NEOs). While there are reasons to believe that primitive volatile-rich materials are universally low in albedo, the converse need not be true: the orbital evolution of some dark objects likely has caused them to lose their volatiles by coming too close to the Sun. For all our targets, we give the closest perihelion distance they are likely to have reached (using orbital integrations from Marchi et al. 2009) and corresponding upper limits on the past surface temperature. Low-Δv objects for which both albedo and thermal history may suggest a primitive composition include (162998) 2001 SK162, (68372) 2001 PM9, and (100085) 1992 UY4.

21 CFR 500.55 - Exemption from certain drug-labeling requirements.

Science.gov (United States)

2010-04-01

.... 500.55 Section 500.55 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN..., and sheep, not in excess of 15 milligrams per dosage unit; as an injectable for cats and dogs, not in excess of 0.6 milligram per dosage unit. Barbital sodium. For oral use in cats and dogs, not in excess of...

46 CFR 78.55-1 - Master and chief engineer responsible.

Science.gov (United States)

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Master and chief engineer responsible. 78.55-1 Section... OPERATIONS Carrying of Excess Steam § 78.55-1 Master and chief engineer responsible. It shall be the duty of the master and the engineer in charge of the boilers of any vessel to require that a steam pressure is...

Total elbow arthroplasty in distal humerus fracture in patients older than 65 years.

Directory of Open Access Journals (Sweden)

Gerardo Gallucci

2016-05-01

Full Text Available Objective To report the clinical-functional results of the treatment of humeral distal fractures with a total elbow prosthesis in patients older than 65 years old. Material and methods This retrospective paper was performed in two surgical centers. Criteria inclusion were: patients with humeral distal fractures, > 65 years, operated on with Coonrad-Morrey prostheses, and with a follow-up of  >1 year. Twenty-one patients were included. Twenty were women with an average age of 79 years old. According to AO classification, 13 fractures were type C3, 7 C2 and 1 A2. All patientes were operated on without desinsertion of the extensor mechanism. Average follow-up was 40 months. Results Flexo-extension was 123-17°, with a total arc of mobility of 106° (80 % of the contralateral side. Pain according to AVE was 1. The MEPI was 83 points: 8 patients had excellent results, 11 good, 1 regular and 1 bad. Average DASH score was 24 points. Conclusion Treatment of humeral distal fractures with total elbow arthoplasty in patients older than 65 years old, may lead to a good option of treatment, but indications must be limited to patients with complex fractures, bad bone quality, with osteoporosis and low functional demands.

Centrosomal protein 55 activates NF-?B signalling and promotes pancreatic cancer cells aggressiveness

OpenAIRE

Peng, Tao; Zhou, Wei; Guo, Feng; Wu, He-shui; Wang, Chun-you; Wang, Li; Yang, Zhi-yong

2017-01-01

Centrosomal protein 55 (CEP55) is a microtubule-bundling protein that participants in cell mitosis. It is overexpressed in several solid tumours and promotes the growth and invasion of cancer cells. However, the role of CEP55 in pancreatic cancer (PANC) remains unclear. Herein, upregulated expression of CEP55 (associated with poor prognosis) was detected in PANC using quantitative real-time reverse transcription PCR, western blotting, and immunohistochemistry. Cell migration, colony formation...

40 CFR 428.65 - Standards of performance for new sources.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Standards of performance for new sources. 428.65 Section 428.65 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS RUBBER MANUFACTURING POINT SOURCE CATEGORY Medium-Sized General Molded...

Short communication: molecular characterization of dog and cat p65 subunits of NF-kappaB.

Science.gov (United States)

Ishikawa, Shingo; Takemitsu, Hiroshi; Li, Gebin; Mori, Nobuko; Yamamoto, Ichiro; Arai, Toshiro

2015-04-01

Nuclear factor kappa B (NF-κB) plays an important role in the immune system. The p65 subunit is an important part of NF-κB unit, and studies of dog and cat p65 subunits of NF-κB (dp65 and cp65) are important in understanding their immune function. In this study, we described the molecular characterization of dp65 and cp65. The dp65 and cp65 complementary DNA encoded 542 and 555 amino acids, respectively, showing a high sequence homology with the mammalian p65 subunit (>87.5%). Quantitative polymerase chain reaction revealed that the p65 messenger RNA is highly expressed in the dog stomach and cat heart and adipose tissue. Functional NF-κB promoter-luciferase reporter vectors revealed that our isolated dp65 and cp65 cDNA encodes a functionally active protein. Transiently expressed dp65 and cp65 up-regulated pro-inflammatory cytokine expression levels in dog and cat, respectively. These findings suggest that dp65 and cp65 play important roles in regulating immune function. Copyright © 2015 Elsevier Ltd. All rights reserved.

Oxygen isotope effect on 55Mn nuclear magnetic shielding in permanganate

International Nuclear Information System (INIS)

Haase, A.R.; Lutz, O.; Mueller, M.; Nolle, A.

1976-01-01

By Fourier transform NMR spectroscopy the 55 Mn resonance lines of the different permanganate species 55 Mn 16 Osub(4-n) 18 Osub(n) - (n=0,1,2,3,4) have been resolved in aqueous solutions of potassium permanganate. An isotope effect on the Larmor frequency of 55 Mn of (0.599 +- 0.015)ppm to lower frequency was found for the substition of an 16 O atom by an 18 O atom in the permanganate ion. An oxygen exchange rate in the permanganate-water system is given. (orig.) [de

Radioactive contamination at Chelyabinsk-65, Russia