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Sample records for in24 m8 o48

  1. An application of earthquake prediction algorithm M8 in eastern ...

    Indian Academy of Sciences (India)

    States National Research Council, Panel on Earth- quake Prediction of the ..... The analysis of the frequency–magnitude graph for considering the consistency of the catalog was accomplished by inspection of the cumulative distribution of earthquake ... trol, retrospectively, the efficiency of the modified version of M8 ...

  2. 0.20-m (8-in.) primary burner development report

    International Nuclear Information System (INIS)

    Stula, R.T.; Young, D.T.; Rode, J.S.

    1977-12-01

    High-Temperature Gas-Cooled Reactors (HTGRs) utilize graphite-base fuels. Fluidized-bed burners are being employed successfully in the experimental reprocessing of these fuels. The primary fluidized-bed burner is a unit operation in the reprocessing flowsheet in which the graphite moderator is removed. A detailed description of the development status of the 0.20-m (8-in.) diameter primary fluidized-bed burner as of July 1, 1977 is presented. Experimental work to date performed in 0.10; 0.20; and 0.40-m (4, 8, and 16 in.) diameter primary burners has demonstrated the feasibility of the primary burning process and, at the same time, has defined more clearly the areas in which additional experimental work is required. The design and recent operating history of the 0.20-m-diameter burner are discussed, with emphasis placed upon the evolution of the current design and operating philosophy

  3. Calcarea carbonica derivative complex (M8) as adjuvant treatment of inflammatory mammary carcinoma in a dog

    OpenAIRE

    Simone Domit Guérios; Carolina Camargo de Oliveira; Daniella Matos da Silva; Eneida Janiscki Da Lozzo; Dorly de Freitas Buchi

    2011-01-01

    Background: Inflammatory mammary carcinoma (IMC) is locally aggressive, fast growing, highly malignant tumor that affects humans and dogs. Affected dogs usually are presented with generalized edema, pain, erythema, and skin ulceration in mammary glands. Surgery is not recommended and an effective treatment has not been established [1]. Calcarea carbonica derivative complex (M8) has demonstrated anticancer properties in a murine model, by improving innate immune response against tumor cells [2...

  4. The GIS and analysis of earthquake damage distribution of the 1303 Hongtong M=8 earthquake

    Science.gov (United States)

    Gao, Meng-Tan; Jin, Xue-Shen; An, Wei-Ping; Lü, Xiao-Jian

    2004-07-01

    The geography information system of the 1303 Hongton M=8 earthquake has been established. Using the spatial analysis function of GIS, the spatial distribution characteristics of damage and isoseismal of the earthquake are studies. By comparing with the standard earthquake intensity attenuation relationship, the abnormal damage distribution of the earthquake is found, so the relationship of the abnormal distribution with tectonics, site condition and basin are analyzed. In this paper, the influence on the ground motion generated by earthquake source and the underground structures near source also are studied. The influence on seismic zonation, anti-earthquake design, earthquake prediction and earthquake emergency responding produced by the abnormal density distribution are discussed.

  5. FY 2016 Status Report on the Modeling of the M8 Calibration Series using MAMMOTH

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Benjamin Allen [Idaho National Lab. (INL), Idaho Falls, ID (United States); Ortensi, Javier [Idaho National Lab. (INL), Idaho Falls, ID (United States); DeHart, Mark David [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-09-01

    This report provides a summary of the progress made towards validating the multi-physics reactor analysis application MAMMOTH using data from measurements performed at the Transient Reactor Test facility, TREAT. The work completed consists of a series of comparisons of TREAT element types (standard and control rod assemblies) in small geometries as well as slotted mini-cores to reference Monte Carlo simulations to ascertain the accuracy of cross section preparation techniques. After the successful completion of these smaller problems, a full core model of the half slotted core used in the M8 Calibration series was assembled. Full core MAMMOTH simulations were compared to Serpent reference calculations to assess the cross section preparation process for this larger configuration. As part of the validation process the M8 Calibration series included a steady state wire irradiation experiment and coupling factors for the experiment region. The shape of the power distribution obtained from the MAMMOTH simulation shows excellent agreement with the experiment. Larger differences were encountered in the calculation of the coupling factors, but there is also great uncertainty on how the experimental values were obtained. Future work will focus on resolving some of these differences.

  6. Recent advances in the study of live attenuated cell-cultured smallpox vaccine LC16m8.

    Science.gov (United States)

    Eto, Akiko; Saito, Tomoya; Yokote, Hiroyuki; Kurane, Ichiro; Kanatani, Yasuhiro

    2015-11-09

    LC16m8 is a live, attenuated, cell-cultured smallpox vaccine that was developed and licensed in Japan in the 1970s, but was not used in the campaign to eradicate smallpox. In the early 2000s, the potential threat of bioterrorism led to reconsideration of the need for a smallpox vaccine. Subsequently, LC16m8 production was restarted in Japan in 2002, requiring re-evaluation of its safety and efficacy. Approximately 50,000 children in the 1970s and about 3500 healthy adults in the 2000s were vaccinated with LC16m8 in Japan, and 153 adults have been vaccinated with LC16m8 or Dryvax in phase I/II clinical trials in the USA. These studies confirmed the safety and efficacy of LC16m8, while several studies in animal models have shown that LC16m8 protects the host against viral challenge. The World Health Organization Strategic Advisory Group of Experts on Immunization recommended LC16m8, together with ACAM2000, as a stockpile vaccine in 2013. In addition, LC16m8 is expected to be a viable alternative to first-generation smallpox vaccines to prevent human monkeypox. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Foreshocks and aftershocks of the 2014 M8.1 Iquique, northern Chile, megathrust earthquake

    Science.gov (United States)

    Soto, Hugo; Sippl, Christian; Schurr, Bernd; Asch, Günter; Tilmann, Frederik; Comte, Diana; Ruiz, Sergio; Oncken, Onno

    2017-04-01

    The M8.1 2014 Iquique earthquake broke a central piece of the long-standing, >500 km long northern Chile seismic gap. The Iquique earthquake sequence started off with a M6.7 thrust event presumably in the upper plate seaward of the Chilean coastline. Deformation was quickly transferred onto the megathrust with three more events of M>6 until it culminated in the mainshock that broke a compact asperity with possibly up to 12 m of slip two weeks later. The mainshock was followed by vigorous aftershock sequence, including a M7.7 event just south of the main slip patch approx. two days later. The whole sequence of events was well recorded by the Integrated Plate Boundary Observatory Chile (IPOC). The IPOC network was complemented quickly after the first large foreshock by 60 additional temporary seismic stations deployed by the University of Chile and the German Research Centre for Geosciences - GFZ. Processing the continuous data with an automated multi-step process for event detection, association and phase picking, we located more than 25,000 events for one month preceding and nine months following the Iquique mainshock. Whereas the foreshocks skirt around the updip limit of the mainshock asperity, the aftershocks agglomerate in two belts, one updip and one downdip of the main asperity offshore the Chilean coast. The deepest events on the plate interface reach 65 km depth in two separated clusters under the coastal cordillera, which show a significant difference in dip, indicating strong long-wavelength slab topography or a slab tear. We will also analyze upper- and deeper intra-plate seismicity and in particular its changes following the Iquique mainshock.

  8. Streamflow Response to the 2010 M8.8 Maule Earthquake

    Science.gov (United States)

    Mohr, C.; Wang, C.

    2011-12-01

    Stream discharge in 10 forest-covered catchments on the eastern slopes of the Coastal range in the Bío-Bío Region of Chile changed after the M8.8 Maule earthquake of 27 February 2010. Since all catchments are restricted to the very uplands, the changes in flow can only be attributed either to changes in the hydraulic head or in the permeability within the catchments. Most streams showed a decrease in discharge immediately after the earthquake followed by a gradual increase for variable amount of time. Maximum post-seismic base flow in discharge exceeded the pre-seismic flow by factor four and discharge did not return to the pre-seismic flow conditions 3 months after the earthquake, despite the lack of rainfall throughout the post-quake period. Unchanged water temperature after the earthquake suggests a near-surface source of the excess flow. Recession analysis revealed unchanged lateral permeability conditions between pre- and post-seismic conditions. Models of enhanced vertical permeability and increased hydraulic head can both describe the post-seismic increase in streamflow but have difficulty in explaining the initial decline. The initial decline in streamflow suggests the occurrence of coseismic dilantancy of the near-surface material, which led to an initial decline in water table and thus in the baseflow to the streams. Coseismic dilatancy of the near-surface material may be consistent with the model of enhanced vertical permeability but inconsistent with the model of increased hydraulic head. The basins of this study are part of an investigation performed under the Fondecyt 1070218 and with additional support from Forestry SA Mininco and the Potsdam Graduate School. Keywords: earthquake, hydrologic response, vertical permeability, dilatancy.

  9. Characteristic of extract derived from purification of morpholine formate distillate M-8 from Azerbaijan petroleum by ionic liquid

    International Nuclear Information System (INIS)

    Mamedov, R.B.; Samedova, F.I.; Ibragimova, M.D.; Gasanova, R.Z.; Nagiyev, V.A.

    2009-01-01

    The characteristics of extract derived from purification of M-8 oil distillate from Azerbaijan petroleum by ionic liquid - complex amine of morpholine and formic acid is given in this paper. It is shown that in contrast to extract derived from purification of M-8 distillate by furfural this one does not contain methane-naphthenic hydrocarbons and consists of 65 percent of aromatic hydrocarbons having different parameters. Extract can be used as a component of bitumen or aromatic oil

  10. The September 2017 M=8.1 Chiapas and M=7.1 Puebla, Mexico, earthquakes: Chain reaction or coincidence?

    Science.gov (United States)

    Toda, S.; Stein, R. S.

    2017-12-01

    The M=8.1 and M=7.1 events struck 12 days and 600 km apart, both with an independent probability of occurrence of 0.5% per year, based on the GEAR model [Bird et al., 2015]. Are they related? First, we calculated the static stress imparted by the M=8.1 shock to the fault that ruptured in the M=7.1, and find a tiny push that would favor rupture. But the stress increase (0.2 kPa) is less than the fault would experience from the tidal stresses, and so it should be inconsequential. We next used the México Servicio Sismológico Nacional (UNAM) online catalog to look at the quakes in the month before the M=8.1 and in the 13 days since. We calculate the completeness to be M≥4.0. There are virtually no remote aftershocks from the Chiapas rupture that extend within 250 km of the M=7.1 shock during the first week after the M=8.1. So, if anything, the M=8.1 turned off for a week or more the region that ruptured in the M=7.1. Events started turning on about 2-3 days before the M=7.1, but none of those struck within 40 km of the future M=7.1 mainshock. The seismic surface waves unleashed by great earthquakes envelop the globe in just 160 minutes, and yet triggering of remote large aftershocks during these 2-3 hours is either very rare [Pollitz et al., Nature 2012] or in dispute [Fan & Shearer, 2016 vs. Yue et al., 2017]. So, the waves must trigger tiny shocks that cascade into larger shocks after some delay. Or, perhaps the stresses conveyed by the waves pump pockets of fluids that slowly diffuse into nearby fault zones, lubricating them to the point of failure [Parsons at al., 2017]. In the cases where great earthquakes are indisputably seen to trigger aftershocks at great distances or even globally, they to do so within several days, or a week at most. Since Puebla struck 12 days later, this seems to us too long a period to be explained by dynamic triggering. Even though neither quake on their own is rare, what's the chance of independent M=8.1 and M=7.1 events just 12

  11. A spatial analysis on seismo-ionospheric anomalies observed by DEMETER during the 2008 M8.0 Wenchuan earthquake

    Science.gov (United States)

    Liu, J. Y.; Chen, Y. I.; Huang, C. C.; Parrot, M.; Shen, X. H.; Pulinets, S. A.; Yang, Q. S.; Ho, Y. Y.

    2015-12-01

    This paper examines seismo-ionospheric anomalies (SIAs) observed by the French satellite DEMETER (Detection of Electro-Magnetic Emissions Transmitted from Earthquake Regions) during the 12 May 2008 M8.0 Wenchuan earthquake. Both daytime and nighttime electron density (Ne), electron temperature (Te), ion density (Ni) and ion temperature (Ti) are investigated. A statistical analysis of the box-and-whisker method is utilized to see if the four DEMETER datasets 1-6 days before and after the earthquake are significantly different. The analysis is employed to investigate the epicenter and three reference areas along the same magnetic latitude discriminating the SIAs from global effects. Results show that the nighttime Ne and Ni (daytime Ti) over the epicenter significantly decrease (increase) 1-6 days before the earthquake. The intersections of the global distribution of the significant differences (or anomalous changes) in the nighttime Ne, the nighttime Ni, and the daytime Ti 1-6 days before and after the earthquake specifically appear over the epicenter, which strongly suggests that DEMETER observes SIAs of the 2008 M8.0 Wenchuan earthquake.

  12. Rescue of Na+ and H+ binding in Na+,K+-ATPase M8 aspartate mutants by secondary mutation

    DEFF Research Database (Denmark)

    Holm, Rikke; Einholm, Anja P.; Andersen, Jens Peter

    A mutation replacing the aspartate in transmembrane segment M8 in the a3-isoform of Na,K-ATPase with asparagine has been found in patients with rapid-onset dystonia parkinsonism or alternating hemiplegia of childhood. This aspartate may be a critical Na+ coordinating residue, but the crystal......-isoforms of Na,K-ATPase, and much smaller effects were seen for other mutations to the M8 aspartate, which were less disruptive of Na+ binding than mutations to other residues related to Na+ site III. The D928 (rat a1 numbering) mutations strongly diminished the cooperativity of Na+ binding. Moreover the p......H optimum of Na,K-ATPase activity was left-shifted, again with D928N being most disruptive. The reduced affinity for activating Na+ and for inhibitory protons, caused by D928N and D928A mutations, could be rescued by introduction of an additional mutation of a glutamate located far away from D928....

  13. Construction and characterization of bacterial artificial chromosomes harboring the full-length genome of a highly attenuated vaccinia virus LC16m8.

    Directory of Open Access Journals (Sweden)

    Tomoki Yoshikawa

    Full Text Available LC16m8 (m8, a highly attenuated vaccinia virus (VAC strain, was developed as a smallpox vaccine, and its safety and immunogenicity have been confirmed. Here, we aimed to develop a system that recovers infectious m8 from a bacterial artificial chromosome (BAC that retains the full-length viral genomic DNA (m8-BAC system. The infectious virus was successfully recovered from a VAC-BAC plasmid, named pLC16m8-BAC. Furthermore, the bacterial replicon-free virus was generated by intramolecular homologous recombination and was successfully recovered from a modified VAC-BAC plasmid, named pLC16m8.8S-BAC. Also, the growth of the recovered virus was indistinguishable from that of authentic m8. The full genome sequence of the plasmid, which harbors identical inverted terminal repeats (ITR to that of authentic m8, was determined by long-read next-generation sequencing (NGS. The ITR contains x 18 to 32 of the 70 and x 30 to 45 of 54 base pair tandem repeats, and the number of tandem repeats was different between the ITR left and right. Since the virus recovered from pLC16m8.8S-BAC was expected to retain the identical viral genome to that of m8, including the ITR, a reference-based alignment following a short-read NGS was performed to validate the sequence of the recovered virus. Based on the pattern of coverage depth in the ITR, no remarkable differences were observed between the virus and m8, and the other region was confirmed to be identical as well. In summary, this new system can recover the virus, which is geno- and phenotypically indistinguishable from authentic m8.

  14. To which level did the 2010 M 8.8 Maule earthquake fill the pre-existing seismic gap?

    Science.gov (United States)

    Wang, Lifeng; Hainzl, Sebastian; Mai, P. Martin

    2017-10-01

    There is a long-standing debate whether or not the 2010 M 8.8 Maule earthquake filled a pre-existing seismic gap in which no large earthquake occurred for about 200 yr. Utilizing the inversion approach of Wang et al. that considers elastic strain accumulation and strain release during the earthquake cycle and includes the fault-coupling state as prior information in coseismic slip modelling, we investigate the inter- and coseismic slip balance for the 2010 M 8.8 Maule earthquake. The coseismic slip model is obtained as the product of three components: the interseismic backslip rate, the strain accumulation time, and the fraction of coseismically released slip potency (the product of slip and slip area) that may either fully or partially release the local strain. We construct slip models using the Slab1.0 fault geometry, and constrain the strain accumulation time for the 2010 Maule earthquake based on historical large earthquakes in the region. The results demonstrate that two slip clusters (north and south of the hypocentre) are required to model the geodetically measured coseismic displacements. The slip patch south of the hypocentre is located in a strongly coupled zone, and possibly released the local strain completely. The slip area north of the hypocentre overlaps with the interseismically creeping zone in which strain buildup may be low. The northern slip patch released higher slip potency than accumulated since the last mega-event in 1751, suggesting a possible dynamic overshoot during coseismic rupture (under the assumption that the last major earthquake has reset the regional strain). Alternatively, the last big event may not have fully released the strain in this region. Our study reveals that the Maule earthquake, combing its coseismic and post-seismic slip over 1.3 yr, released ˜67-72 per cent of the local strain. Remaining strain is concentrated mainly south of the hypocentre, with potency equivalent to an M 8.4 event considering strain accumulation

  15. Seismo-Traveling Ionospheric Disturbances Triggered by the 12 May 2008 M 8.0 Wenchuan Earthquake

    Directory of Open Access Journals (Sweden)

    Jann-Yenq Liu

    2012-01-01

    Full Text Available A network of 6 ground-based GPS receivers in East Asia was employed to study seismo-traveling ionospheric disturbances (STIDs triggered by an M 8.0 earthquake which occurred at Wenchuan on 12 May 2008. The network detected 5 STIDs on the south side of the epicenter area. A study on the distances of the detected STIDs to the epicenter versus their associated traveling times shows that the horizontal speed is about 600 m s-1. Applying the circle method, we find that the 5 circles intercept at a point right above the epicenter when the horizontal speed of 600 m s-1 is given. Global searches of the ray-tracing and the beam-forming techniques confirm that the STIDs are induced by vertical motions in the Earth¡¦s surface during the Wenchuan Earthquake.

  16. A ceramic nozzle for the NASA-Langley 2.4-m /8.0-ft/ high temperature structures tunnel

    Science.gov (United States)

    Buckley, J. D.; Vasquez, P.

    1982-01-01

    Two materials, a refractory castable ceramic and a SiO2-SiO2 composite, were fabricated as nozzle inserts for the Langley Research Center's 2.4-m (8.0-ft) high temperature structures tunnel. The high pressure and intense heat of the CH4-air products of the combustion-gas stream limits the materials that can be used in this tunnel. The castable-ceramic material showed good resistance to erosion and the thermal loads imposed on it by the gas stream but failed in tension when subjected to high hoop stresses. The SiO2-SiO2-composite nozzle insert withstood the thermomechanical loads but eroded unacceptably with increasing test temperature and pressure.

  17. Salmonella O48 Serum Resistance is Connected with the Elongation of the Lipopolysaccharide O-Antigen Containing Sialic Acid

    Directory of Open Access Journals (Sweden)

    Aleksandra Pawlak

    2017-09-01

    Full Text Available Complement is one of the most important parts of the innate immune system. Some bacteria can gain resistance against the bactericidal action of complement by decorating their outer cell surface with lipopolysaccharides (LPSs containing a very long O-antigen or with specific outer membrane proteins. Additionally, the presence of sialic acid in the LPS molecules can provide a level of protection for bacteria, likening them to human cells, a phenomenon known as molecular mimicry. Salmonella O48, which contains sialic acid in the O-antigen, is the major cause of reptile-associated salmonellosis, a worldwide public health problem. In this study, we tested the effect of prolonged exposure to human serum on strains from Salmonella serogroup O48, specifically on the O-antigen length. After multiple passages in serum, three out of four tested strains became resistant to serum action. The gas-liquid chromatography/tandem mass spectrometry analysis showed that, for most of the strains, the average length of the LPS O-antigen increased. Thus, we have discovered a link between the resistance of bacterial cells to serum and the elongation of the LPS O-antigen.

  18. The Gaia-ESO Survey: dynamics of ionized and neutral gas in the Lagoon nebula (M 8)

    Science.gov (United States)

    Damiani, F.; Bonito, R.; Prisinzano, L.; Zwitter, T.; Bayo, A.; Kalari, V.; Jiménez-Esteban, F. M.; Costado, M. T.; Jofré, P.; Randich, S.; Flaccomio, E.; Lanzafame, A. C.; Lardo, C.; Morbidelli, L.; Zaggia, S.

    2017-08-01

    Aims: We present a spectroscopic study of the dynamics of the ionized and neutral gas throughout the Lagoon nebula (M 8), using VLT-FLAMES data from the Gaia-ESO Survey. The new data permit exploration of the physical connections between the nebular gas and the stellar population of the associated star cluster NGC 6530. Methods: We characterized through spectral fitting emission lines of Hα, [N II] and [S II] doublets, [O III], and absorption lines of sodium D doublet, using data from the FLAMES-Giraffe and UVES spectrographs, on more than 1000 sightlines toward the entire face of the Lagoon nebula. Gas temperatures are derived from line-width comparisons, densities from the [S II] doublet ratio, and ionization parameter from Hα/[N II] ratio. Although doubly-peaked emission profiles are rarely found, line asymmetries often imply multiple velocity components along the same line of sight. This is especially true for the sodium absorption, and for the [O III] lines. Results: Spatial maps for density and ionization are derived, and compared to other known properties of the nebula and of its massive stars 9 Sgr, Herschel 36 and HD 165052 which are confirmed to provide most of the ionizing flux. The detailed velocity fields across the nebula show several expanding shells, related to the cluster NGC 6530, the O stars 9 Sgr and Herschel 36, and the massive protostar M 8East-IR. The origins of kinematical expansion and ionization of the NGC 6530 shell appear to be different. We are able to put constrains on the line-of-sight (relative or absolute) distances between some of these objects and the molecular cloud. The data show that the large obscuring band running through the middle of the nebula is being compressed by both sides, which might explain its enhanced density. We also find an unexplained large-scale velocity gradient across the entire nebula. At larger distances, the transition from ionized to neutral gas is studied using the sodium lines. Based on observations

  19. Essential role of transient receptor potential M8 (TRPM8) in a model of acute cold-induced urinary urgency.

    Science.gov (United States)

    Uvin, Pieter; Franken, Jan; Pinto, Silvia; Rietjens, Roma; Grammet, Luc; Deruyver, Yves; Alpizar, Yeranddy A; Talavera, Karel; Vennekens, Rudi; Everaerts, Wouter; De Ridder, Dirk; Voets, Thomas

    2015-10-01

    Acute exposure of part of the skin to cold stimuli can evoke urinary urgency, a phenomenon termed acute cold-induced urgency (ACIU). Despite its high prevalence, particularly in patients with overactive bladder, little is known about the mechanisms that induce ACIU. To develop an animal model of ACIU and test the involvement of cold-activated ion channels transient receptor potential (TRP) M8 and TRPA1. Intravesical pressure and micturition were monitored in female mice (wild-type C57BL/6J, Trpa1(-/-), Trpm8(+/+), and Trpm8(-/-)) and Sprague Dawley rats. An intravesical catheter was implanted. Localized cooling of the skin was achieved using a stream of air or topical acetone. The TRPM8 antagonist (N-(3-aminopropyl)-2-{[(3-methylphenyl) methyl]oxy}-N-(2-thienylmethyl)benzamide (AMTB) or vehicle was injected intraperitoneally. Frequencies of bladder contractions and voids in response to sensory stimuli were compared using the Mann-Whitney or Kruskal-Wallis test. Brief, innocuously cold stimuli applied to different parts of the skin evoked rapid bladder contractions and voids in anesthetized mice and rats. These responses were strongly attenuated in Trpm8(-/-) mice and in rats treated with AMTB. As rodent bladder physiology differs from that of humans, it is difficult to directly extrapolate our findings to human patients. Our findings indicate that ACIU is an evolutionarily conserved reflex rather than subconscious conditioning, and provide a useful in vivo model for further investigation of the underlying mechanisms. Pharmacological inhibition of TRPM8 may be useful for treating ACIU symptoms in patients. Brief cold stimuli applied to the skin can evoke a sudden desire to urinate, which can be highly bothersome in patients with overactive bladder. We developed an animal model to study this phenomenon, and found that it depends on a specific molecular cold sensor, transient receptor potential M8 (TRPM8). Pharmacological inhibition of TRPM8 may alleviate acute cold

  20. Seismogenic ionospheric anomalies associated with the strong Indonesian earthquake occurred on 11 April 2012 (M = 8.5)

    Science.gov (United States)

    Pandey, Uma; Singh, Ashutosh K.; Kumar, Sanjay; Singh, A. K.

    2018-03-01

    Ionospheric perturbations in possible association with a major earthquake (EQ) (M = 8.5) which occurred in India-Oceania region are investigated by monitoring subionospheric propagation of VLF signals transmitted from the NWC transmitter (F = 19.8 kHz), Australia to a receiving station at Varanasi (geographic lat. 25.3°N, long 82.99°E), India. The EQ occurred on 11 April 2012 at 08:38:35 h UT (magnitude ≈ 8.5, depth = 10 km, and lat. = 2.3°N, long. = 93.0°E). A significant increase of few days before the EQ has been observed by using the VLF nighttime amplitude fluctuation method (fixed frequency transmitter signal). The analysis of total electron contents (TEC) derived from the global positioning system (GPS) at three different stations namely, Hyderabad (latitude 17.38°N, longitude 78.48°E), Singapore (latitude 1.37°N, longitude 103.84°E) and Port Blair (latitude 11.62°N, longitude 92.72°E) due to this EQ has also been presented. Significant perturbation in TEC data (enhancements and depletion) is noted before and after the main shock of the EQ. The possible mechanisms behind these perturbations due to EQ have also been discussed.

  1. Preliminary Report Summarizes Tsunami Impacts and Lessons Learned from the September 7, 2017, M8.1 Tehuantepec Earthquake

    Science.gov (United States)

    Wilson, R. I.; Ramirez-Herrera, M. T.; Dengler, L. A.; Miller, K.; LaDuke, Y.

    2017-12-01

    The preliminary tsunami impacts from the September 7, 2017, M8.1 Tehuantepec Earthquake have been summarized in the following report: https://www.eeri.org/wp-content/uploads/EERI-Recon-Rpt-090717-Mexico-tsunami_fn.pdf. Although the tsunami impacts were not as significant as those from the earthquake itself (98 fatalities and 41,000 homes damaged), the following are highlights and lessons learned: The Tehuantepec earthquake was one of the largest down-slab normal faulting events ever recorded. This situation complicated the tsunami forecast since forecast methods and pre-event modeling are primarily associated with megathrust earthquakes where the most significant tsunamis are generated. Adding non-megathrust source modeling to the tsunami forecast databases of conventional warning systems should be considered. Offshore seismic and tsunami hazard analyses using past events should incorporate the potential for large earthquakes occurring along sources other than the megathrust boundary. From an engineering perspective, initial reports indicate there was only minor tsunami damage along the Mexico coast. There was damage to Marina Chiapas where floating docks overtopped their piles. Increasing pile heights could reduce the potential for damage to floating docks. Tsunami warning notifications did not get to the public in time to assist with evacuation. Streamlining the messaging in Mexico from the warning system directly to the public should be considered. And, for local events, preparedness efforts should place emphasis on responding to feeling the earthquake and not waiting to be notified. Although the U.S. tsunami warning centers were timely with their international and domestic messaging, there were some issues with how those messages were presented and interpreted. The use of a "Tsunami Threat" banner on the new main warning center website created confusion with emergency managers in the U.S. where no tsunami threat was expected to exist. Also, some U.S. states and

  2. The Effect of β-Carotene Supplementation on the Pharmacokinetics of Nelfinavir and Its Active Metabolite M8 in HIV-1-infected Patients

    Directory of Open Access Journals (Sweden)

    Humayoun Akhtar

    2012-01-01

    Full Text Available β-Carotene supplements are often taken by individuals living with HIV-1. Contradictory results from in vitro studies suggest that β-carotene may inhibit or induce cytochrome P450 enzymes and transporters. The study objective was to investigate the effect of β-carotene on the steady-state pharmacokinetics of nelfinavir and its active metabolite M8 in HIV-1 infected individuals. Twelve hour nelfinavir pharmacokinetic analysis was conducted at baseline and after 28 days of β-carotene supplementation (25,000 IU twice daily. Nelfinavir and M8 concentrations were measured with validated assays. Non-compartmental methods were used to calculate the pharmacokinetic parameters. Geometric mean ratios comparing day 28 to day 1 area under the plasma concentration-time curve (AUC0–12 h, maximum (Cmax and minimum (Cmin concentrations of nelfinavir and M8 are presented with 90% confidence intervals. Eleven subjects completed the study and were included in the analysis. There were no significant differences in nelfinavir AUC0–12 h and Cmin (−10%, +4% after β-carotene supplementation. The M8 Cmin was increased by 31% while the M8 AUC0–12 h and Cmax were unchanged. During the 28 day period, mean CD4+ % and CD4+:CD8+ ratio increased significantly (p < 0.01. β-carotene supplementation increased serum carotene levels but did not cause any clinically significant difference in the nelfinavir and M8 exposure.

  3. Is there physical evidence that the M8.2 8-Sep-17 earthquake triggered the M7.1 19-Sep-17 earthquake?

    Science.gov (United States)

    Husker, A. L.; Guillermo, G. M., Sr.; Kostoglodov, V.; Dominguez, L. A.; Franco-Sánchez, S. I.; Kazachkina, E.

    2017-12-01

    The recent large Mexican earthquakes occurred 11 1/2 days and about 600 km apart. The static stress of the first earthquake was not enough to trigger the second (Stein et al., 2017). 11+ days may be too long a time for dynamic triggering to play a role as well. However, Walter et al. (2015) found a link between two M7+ earthquakes that were 9 days and 450km apart in Central America. We use their technique to look for evidence in Mexico. Aftershocks from the second earthquake are used as templates in a match-filter search. In Central America, the technique revealed numerous earthquakes in the location of the second earthquake, but occurring shortly after the first earthquake. In Mexico, the second earthquake only had 11 aftershocks that could be used as templates as there were very few aftershocks (Mexican National Seismological Service - SSN). The match filter search found a total of 21 matches after the M7.1, including the original 11 earthquakes. 1 event occurred 5 days after the M8.2, but there were other events during the month of September before the M8.2. This is very different from the case in Central America where more than 20 events occurred at the site of the second earthquake within 3 hours of the first (Walter et al., 2015). These earthquakes do not give physical evidence of triggering, but perhaps there are smaller earthquakes outside the detection range. We also look for evidence in the GPS signal, but this is complicated by the 2017 Guerrero SSE that started in May. It started earlier than expected, and since it is slip predictable, it was smaller than previous large SSEs in Guerrero. It was ending when the M8.2 occurred, and was reactivated by the M8.2. Thus, GPS signals in southern Mexico contain the post-seismic slip of the M8.2 as well as the SSE. At the time of writing this, there is no clear evidence in the GPS signal of transient slip activated near the M7.1 at the time of the M8.2.

  4. In vitro and in vivo anticancer properties of a Calcarea carbonica derivative complex (M8 treatment in a murine melanoma model

    Directory of Open Access Journals (Sweden)

    Trindade Edvaldo S

    2010-03-01

    Full Text Available Abstract Background Melanoma is the most aggressive form of skin cancer and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have had only marginal success. Previous studies in mice demonstrated that a high diluted complex derived from Calcarea carbonica (M8 stimulated the tumoricidal response of activated lymphocytes against B16F10 melanoma cells in vitro. Methods Here we describe the in vitro inhibition of invasion and the in vivo anti-metastatic potential after M8 treatment by inhalation in the B16F10 lung metastasis model. Results We found that M8 has at least two functions, acting as both an inhibitor of cancer cell adhesion and invasion and as a perlecan expression antagonist, which are strongly correlated with several metastatic, angiogenic and invasive factors in melanoma tumors. Conclusion The findings suggest that this medication is a promising non-toxic therapy candidate by improving the immune response against tumor cells or even induce direct dormancy in malignancies.

  5. CZCSL3M8D

    Data.gov (United States)

    National Aeronautics and Space Administration — The Coastal Zone Color Scanner Experiment (CZCS) was the first instrument devoted to the measurement of ocean color and flown on a spacecraft. Although other...

  6. OCTSL3M8D

    Data.gov (United States)

    National Aeronautics and Space Administration — On August 17, 1996, the Japanese Space Agency (NASDA - National Space Development Agency) launched the Advanced Earth Observing Satellite (ADEOS). ADEOS was in a...

  7. Pre-seismic anomalous geomagnetic signature related to M8.3 earthquake occurred in Chile on September 16-th, 2015

    Science.gov (United States)

    Armand Stanica, Dragos, ,, Dr.; Stanica, Dumitru, ,, Dr.; Vladimirescu, Nicoleta

    2016-04-01

    In this paper, we retrospectively analyzed the geomagnetic data collected, via internet (www.intermagnet.com), on the interval 01 July-30 September 2015 at the observatories Easter Island (IMP) and Pilar (PIL), placed in Chile and Argentina, respectively, to emphasize a possible relationship between the pre-seismic anomalous behavior of the normalized function Bzn and M8.3 earthquake, that occurred in Offshore Coquimbo (Chile) on September 16-th, 2015. The daily mean distributions of the normalized function Bzn=Bz/Bperp (where Bz is vertical component of the geomagnetic field; Bperp is geomagnetic component perpendicular to the geoelectrical strike) and its standard deviation (STDEV) are performed in the ULF frequency range 0.001Hz to 0.0083Hz by using the FFT band-pass filter analysis. It was demonstrated that in pre-seismic conditions the Bzn has a significant enhancement due to the crustal electrical conductivity changes, possibly associated with the earthquake-induced rupture-processes and high-pressure fluid flow through the faulting system developed inside the foci and its neighboring area. After analyzing the anomalous values of the normalized function Bzn obtained at Easter Island and Pilar observatories, the second one taken as reference, we used a statistical analysis, based on a standardized random variable equation, to identify on 1-2 September 2015 a pre-seismic signature related to the M8.3 earthquake. The lead time was 14 days before the M8.3 earthquake occurrence. The final conclusion is that the proposed geomagnetic methodology might be used to provide suitable information for the extreme earthquake hazard assessment.

  8. Evaluation of Dose and Safety of AAV7m8 and AAV8BP2 in the Non-Human Primate Retina.

    Science.gov (United States)

    Ramachandran, Pavitra S; Lee, Vivian; Wei, Zhangyong; Song, Ji Yun; Casal, Giulia; Cronin, Therese; Willett, Keirnan; Huckfeldt, Rachel; Morgan, Jessica I W; Aleman, Tomas S; Maguire, Albert M; Bennett, Jean

    2017-02-01

    Within the next decade, we will see many gene therapy clinical trials for eye diseases, which may lead to treatments for thousands of visually impaired people around the world. To target retinal diseases that affect specific cell types, several recombinant adeno-associated virus (AAV) serotypes have been generated and used successfully in preclinical mouse studies. Because there are numerous anatomic and physiologic differences between the eyes of mice and "men" and because surgical delivery approaches and immunologic responses also differ between these species, this study evaluated the transduction characteristics of two promising new serotypes, AAV7m8 and AAV8BP2, in the retinas of animals that are most similar to those of humans: non-human primates (NHPs). We report that while AAV7m8 efficiently targets a variety of cell types by subretinal injection in NHPs, transduction after intravitreal delivery was mostly restricted to the inner retina at lower doses that did not induce an immune response. AAV8BP2 targets the cone photoreceptors efficiently but bipolar cells inefficiently by subretinal injection. Additionally, transduction by both serotypes in the anterior chamber of the eye and the optic pathway of the brain was observed post-intravitreal delivery. Finally, we assessed immunogenicity, keeping in mind that these AAV capsids may be used in future clinical trials. We found that AAV8BP2 had a better safety profile compared with AAV7m8, even at the highest doses administered. These studies underscore the differences in AAV transduction between mice and primates, highlighting the importance of careful evaluation of therapeutic vectors in NHPs prior to moving to clinical trials.

  9. Arginine substitution of a cysteine in transmembrane helix M8 converts Na+,K+-ATPase to an electroneutral pump similar to H+,K+-ATPase.

    Science.gov (United States)

    Holm, Rikke; Khandelwal, Jaanki; Einholm, Anja P; Andersen, Jens P; Artigas, Pablo; Vilsen, Bente

    2017-01-10

    Na + ,K + -ATPase and H + ,K + -ATPase are electrogenic and nonelectrogenic ion pumps, respectively. The underlying structural basis for this difference has not been established, and it has not been revealed how the H + ,K + -ATPase avoids binding of Na + at the site corresponding to the Na + -specific site of the Na + ,K + -ATPase (site III). In this study, we addressed these questions by using site-directed mutagenesis in combination with enzymatic, transport, and electrophysiological functional measurements. Replacement of the cysteine C932 in transmembrane helix M8 of Na + ,K + -ATPase with arginine, present in the H + ,K + -ATPase at the corresponding position, converted the normal 3Na + :2K + :1ATP stoichiometry of the Na + ,K + -ATPase to electroneutral 2Na + :2K + :1ATP stoichiometry similar to the electroneutral transport mode of the H + ,K + -ATPase. The electroneutral C932R mutant of the Na + ,K + -ATPase retained a wild-type-like enzyme turnover rate for ATP hydrolysis and rate of cellular K + uptake. Only a relatively minor reduction of apparent Na + affinity for activation of phosphorylation from ATP was observed for C932R, whereas replacement of C932 with leucine or phenylalanine, the latter of a size comparable to arginine, led to spectacular reductions of apparent Na + affinity without changing the electrogenicity. From these results, in combination with structural considerations, it appears that the guanidine + group of the M8 arginine replaces Na + at the third site, thus preventing Na + binding there, although allowing Na + to bind at the two other sites and become transported. Hence, in the H + ,K + -ATPase, the ability of the M8 arginine to donate an internal cation binding at the third site is decisive for the electroneutral transport mode of this pump.

  10. An Astrometric Search for a Sub-stellar Companion of the M8.5 Dwarf TVLM 513-46546 Using Very Long Baseline Interferometry

    OpenAIRE

    Forbrich, Jan; Berger, Edo; Reid, Mark J.

    2013-01-01

    We conducted multi-epoch VLBI observations to search for astrometric reflex motion caused by a sub-stellar companion of the M8.5 dwarf TVLM 513–46546. The observations yield an absolute parallax corresponding to a distance of 10.762±0.027 pc and a proper motion of 78.09± 0.17 mas yr−1. From the absence of significant residual motion, we place an upper limit to any reflex motion caused by a companion, extending the parameter space covered by previous near-infrared direct-imaging searches. By c...

  11. Temporal and spatial analyses on seismo-electric anomalies associated with the 27 February 2010 M = 8.8 Chile earthquake observed by DEMETER satellite

    Science.gov (United States)

    Ho, Y.-Y.; Liu, J.-Y.; Parrot, M.; Pinçon, J.-L.

    2013-12-01

    This paper studies seismo-electromagnetic anomalies observed by the French satellite DEMETER (Detection of Electro-Magnetic Emissions Transmitted from Earthquake Regions) during the 27 February 2010 M = 8.8 Chile earthquake. The nighttime electron density (Ne), electron temperature (Te), ion density (Ni), ion temperature (Ti) and whistler counts (Cw) are investigated. A statistical analysis of the box-and-whisker method is applied to see if data of two or more groups under study are significantly different. A cross-examination of temporal variations before and after shows that Ne and Ni (Cw) increases (decreases) appear 10-20 days before the earthquake. A comparison of data over the epicenter and those over its reference area can be employed to discriminate the earthquake-related anomalies from global effects. Results prove that anomalous enhancements of Ne, Ni, and Ti occur specifically around the epicenter area. The intersection of the temporal and spatial results confirms that Ne and Ni are useful and sensitive detecting anomalous related to the 2010 M = 8.8 Chile earthquake.

  12. Spatial analyses on seismo-ionospheric precursors observed by GIM TEC and DEMETER during the 2008 M8.0 Wenchuan earthquake

    Science.gov (United States)

    Liu, Jann-Yenq; Chen, Yuh-Ing; Huang, Ching-Chi; Parrot, Michel; Pulinets, Sergey; Ouzounov, Dimitar

    2015-04-01

    This paper examines seismo-ionospheric precursors (SIPs) in the total electron content (TEC) of the global ionosphere map (GIM) and observations in the French satellite DEMETER (Detection of Electro-Magnetic Emissions Transmitted from Earthquake Regions) during the 12 May 2008 M8.0 Wenchuan earthquake. The temporal and spatial analyses on the GIM TEC are used to search SIPs of the Wenchuan earthquake. Meanwhile, both daytime and nighttime electron density (Ne), electron temperature (Te), ion density (Ni) and ion temperature (Ti) probed by DEMETER are investigated. A statistical analysis of the box-and-whisker method is utilized to see if the four DEMETER data sets 1-6 days before and after the earthquake are significantly different. The analysis is employed to investigate the epicenter and three reference areas along the same magnetic latitude discriminating the SIPs from global effects. Results show that the nighttime Ne and Ni (daytime Ti) over the epicenter significantly decrease (increase) 1-6 days before the earthquake. The intersections of the global distribution of the significant differences (or anomalous changes) in the nighttime Ne, the nighttime Ni, and the daytime Ti 1-6 days before and after the earthquake specifically appear over the epicenter. The spatial analyses confirm that SIPs of GIM TEC and DEMETER observations appearing 2-6 days before are related to the 2008 M8.0 Wenchuan earthquake.

  13. Reevaluation of the offset of the Great Wall associated with the 1739 M 8.0 Pingluo earthquake, Yinchuan Graben, China (Invited)

    Science.gov (United States)

    Lin, A.; Rao, G.; Hu, J.; Gong, W.

    2013-12-01

    The study of large-magnitude earthquakes that occurred prior to the availability of routine instrumental measurements relies mainly on the analysis of historical documents and field observations. Significant uncertainties often exist in relation to the location of the epicenter, the magnitude, and the actual extent of damage, including the number of fatalities, caused by individual historical earthquakes, because records are generally focused on the effects in the restricted regions that were settled. In these cases, field observations of the geologic effects of large historical and paleo-earthquakes provide direct evidence of the co-seismic ground deformation and macro-seismic intensity of these large-magnitude events, and can therefore help to improve our ability to assess seismic hazards in densely populated epicentral regions. The ruins of ancient civilizations that experienced and were damaged by earthquakes are often used as surface indicators in the study of past seismic events in regions with long historical records, such as China, Japan, and Turkey. China is located in one of the most active seismic regions of the world and has experienced numerous destructive earthquakes over its long history. The damage caused by previous large-magnitude earthquakes has been recorded in historical documents, and co-seismic ground deformation is locally preserved in ruined ancient buildings such as temples, tombs, and other constructions erected over the past several thousand years. Previous studies have shown that the Great Wall of China was damaged and offset by the ca. M 8 Pingluo earthquake of 1739 along an active fault zone in the Yinchuan graben, on the western margin of the Ordos Block in northern central China (e.g., Deng and Liao, 1996, JGR; Zhang et al., 1986, BSSA). In this study, we reevaluate, on the basis of our investigation, the ground deformation caused around the area of the Great Wall by the ca. M 8 Pingluo earthquake of 1739 along an active fault zone

  14. Some statistical features of the seismic activity related to the recent M8.2 and M7.1 earthquakes in Mexico

    Science.gov (United States)

    Guzman, L.; Baeza-Blancas, E.; Reyes, I.; Angulo Brown, F.; Rudolf Navarro, A.

    2017-12-01

    By studying the magnitude earthquake catalogs, previous studies have reported evidence that some changes in the spatial and temporal organization of earthquake activity is observedbefore and after of a main-shock. These previous studies have used different approach methods for detecting clustering behavior and distance-events density in order topoint out the asymmetric behavior of before shocks and aftershocks. Here, we present a statistical analysis of the seismic activity related to the M8.2 and M7.1 earthquakes occurredon Sept. 7th and Sept. 19th, respectively. First, we calculated the interevent time and distance for the period Sept. 7th 2016 until Oct. 20th 2017 for each seismic region ( a radius of 150 km centeredat coordinates of the M8.1 and M7.1). Next, we calculated the "velocity" of the walker as the ratio between the interevent distance and interevent time, and similarly, we also constructed the"acceleration". A slider pointer is considered to estimate some statistical features within time windows of size τ for the velocity and acceleration sequences before and after the main shocks. Specifically, we applied the fractal dimension method to detect changes in the correlation (persistence) behavior of events in the period before the main events.Our preliminary results pointed out that the fractal dimension associated to the velocity and acceleration sequences exhibits changes in the persistence behavior before the mainshock, while thescaling dimension values after the main events resemble a more uncorrelated behavior. Moreover, the relationship between the standard deviation of the velocity and the local mean velocity valuefor a given time window-size τ is described by an exponent close to 1.5, and the cumulative distribution of velocity and acceleration are well described by power law functions after the crash and stretched-exponential-like distribution before the main shock. On the other hand, we present an analysis of patterns of seismicquiescence

  15. Testing Earthquake Links in Mexico From 1978 to the 2017 M = 8.1 Chiapas and M = 7.1 Puebla Shocks

    Science.gov (United States)

    Segou, Margarita; Parsons, Tom

    2018-01-01

    The M = 8.1 Chiapas and the M = 7.1 Puebla earthquakes occurred in the bending part of the subducting Cocos plate 11 days and 600 km apart, a range that puts them well outside the typical aftershock zone. We find this to be a relatively common occurrence in Mexico, with 14% of M > 7.0 earthquakes since 1900 striking more than 300 km apart and within a 2 week interval, not different from a randomized catalog. We calculate the triggering potential caused by crustal stress redistribution from large subduction earthquakes over the last 40 years. There is no evidence that static stress transfer or dynamic triggering from the 8 September Chiapas earthquake promoted the 19 September earthquake. Both recent earthquakes were promoted by past thrust events instead, including delayed afterslip from the 2012 M = 7.5 Oaxaca earthquake. A repeated pattern of shallow thrust events promoting deep intraslab earthquakes is observed over the past 40 years.

  16. Ionospheric F2-layer Perturbations Observed After the M8.8 Chile Earthquake on February 27, 2010, at Long Distance from the Epicenter

    Directory of Open Access Journals (Sweden)

    Valery V. Hegai

    2017-03-01

    Full Text Available The F2-layer critical frequency (foF2 data from several ionosondes are employed to study the long-distance effect of the M8.8 Chile Earthquake of February 27, 2010, on the F2 layer. Significant perturbations of the peak F2-layer electron density have been observed following the earthquake at two South African stations, Hermanus and Madimbo, which are located at great circle distances of ~8,000 and ~10,000 km from the earthquake epicenter, respectively. Simplified estimates demonstrate that the observed ionospheric perturbations can be caused by a long-period acoustic gravity wave produced in the F-region by the earthquake.

  17. Uncertainty of the GPS-Based Tsunami Forecasting: A Case Study for the April 2014 M8.0 Pisagua, Chile Earthquake

    Science.gov (United States)

    Chen, K.; Babeyko, A. Y.

    2014-12-01

    Real-time GPS is nowadays considered as a valuable component of next-generation near-field tsunami early warning systems. Whereas the idea of using GPS for tsunami early warning is clear, its practical implementation still requires extensive studies and validation against real events. The northern Chile 1 Apr. 2014 M8.0 Pisagua earthquake and resulting tsunami was extensively recorded by large number of land- and ocean-based sensors including real-time GPS. Earthquakes of this magnitude range (M7.0-M8.0) are especially challenging for tsunami warning centre since, in contrast to the mega-earthquakes, they do not necessary trigger devastating tsunamis. GPS-fingeprints of such earthquakes may also approach the limit of real-time detect ability. Thus, earthquakes of such a magnitude range fall in "a blurred zone", a zone of higher uncertainty in sense of tsunami early warning. We take the opportunity and consider the 2014 Pisagua event as a case study to explore possible sources and magnitudes of uncertainty in the GPS-based real-time tsunami forecasting. In particular, we test uncertainties related to derivation of real-time source model: (1) Uncertainty of co-seismic displacements retrieved by different real-time GPS-processing strategy: precise relative positioning and precise point positioning; by different software platform: RTKLIB, PANDA, EPOS-RT, Bernese (post) (2) Uncertainty of source inversion by different approaches: single Okada fault, distributed slip in homogeneous and layered half space. We consider individual uncertainties as well as their propagation to the final tsunami forecasting. As a result, "up streams" and "down streams" are combined together, in which case a "close loop" criteria is illustrated for evaluation of uncertainty of the GPS-based tsunami forecasting.

  18. The Great 1787 Earthquake (M 8.6) and Tsunami along The Mexican Subduction Zone - History, Geology and Tsunami Hazard Assessment

    Science.gov (United States)

    Ramirez-Herrera, M. T.; Lagos, M.; Goguitchaichvili, A.; Machain-Castillo, M. L.; Caballero, M.; Ruiz-Fernandez, A. C.; Suarez, G.; Ortuño, M.

    2017-12-01

    The 1787 great earthquake (M 8.6) triggered a deadly tsunami that poured over the coast of Oaxaca, Guerrero, and Chiapas, along more than 500 km of the Mexican Pacific coast and up to 6 km inland. This tsunami, according with historical documents, destroyed mostly farmlands and livestock, and damaged few villages since the density of population was sparse at the time. We report first on geological evidence from the Corralero lagoon and adjacent coastal plain that seem in agreement with historical accounts. The deposit left by the 1787 tsunami can be traced along a transect of cores and test pits from the coastline and up to 1.6 km inland. The test pits showed an anomalous sand layer that was deposited in a single event in the swales of a series of beach ridges. The anomalous layer is almost continuous along the transect, about a 1000 m-long, and is formed of coarse to medium sand, at variable depths, with variable thickness, and pinching up with the distance from the coastline. We used stratigraphy, grain size, microfossils (foraminifera and diatoms), magnetic susceptibility and anisotropy of magnetic susceptibility proxies to reveal the nature of this anomalous sand layer. Stratigraphy, abrupt contacts, and magnetic properties support a sudden and rapid event, consisting of sands transported most probably by an extreme sea-wave far inland. Furthermore, based on the accounts of the 1787 earthquake (M 8.6) and tsunami, and estimates from 210Pb sedimentation rates, we suggest that this is the tsunami deposit left by the 1787 event. Tsunami modeling will further enhance the hazard and risk assessment of this area in Mexico.

  19. Thermal, Petrologic, and Structural Conditions for the September 2017 M=8.2 and M=7.1 intra-slab earthquakes in Mexico

    Science.gov (United States)

    Wang, K.; Gao, X.; Rogers, G. C.

    2017-12-01

    The M=8.2 Tehuantepec and M=7.1 Puebla earthquakes of September 2017 are similar to the 1999 Oaxaca (M=7.5, Mexico), 2001 Geiyo (M=6.7, Nankai), and 2001 Nisqually (M=6.8, Cascadia) earthquakes. All these events are normal-faulting events in the 40-60 km depth range within young and warm subducting slabs. They all ruptured the mantle part of the slab. To investigate the thermal and petrologic conditions of these earthquakes, we have developed finite element thermal models in the areas of the two September events. Along the northern transect for the M=7.1 event, where the age of the incoming plate is 13.5 Ma, the slab geometry is well constrained by previous receiver function and earthquake location studies. Two available hypocenter locations of the main shock fall within or at the lower boundary of our model-predicted zone of serpentine (antigorite) stability in the slab mantle. Along the southern transect for the M=8.2 event, where the age of the incoming plate is 25.5 Ma, the slab geometry is less well known, and we have considered two published geometrical models. Several available hypocenter locations of the main shock are within or below the serpentine stability zone, depending on which slab geometry is assumed. Most of the rupture zone is shallower than the hypocenter. The model results support the following hypothesis. The two September earthquakes probably ruptured pre-existing normal faults that extended into the oceanic mantle and had been locally hydrated prior to and during the beginning phase of subduction. The earthquakes may have initiated at the dehydration boundary of antigorite or chlorite, facilitated by elevated pore fluid pressure (dehydration embrittlement). Most of the rupture was in the uppermost mantle part of the slab but may have involved parts of the slab crust. That large intra-slab earthquakes of this type tend to involve mantle rupture has been explained as due to the structural condition caused by warm-slab metamorphism (Wang et al

  20. Re-examination on the 1891 M8.0 Nobi Earthquake, Japan: Collspse rate distributions in cities, towns and villages

    Science.gov (United States)

    Kimata, F.; Matta, N.

    2014-12-01

    The 1891 M8.0 Nobi Earthquake is the greatest inland earthquakes in Japan. The Neodani Fault was slipped for 80 km length at the earthquake. Over 7000 peoples was perished around Gifu prefecture, central Japan by the earthquake. It was passed 20 years to be established a constitutional monarchy in Japan, and Meiji government modernized oneself after the West. The cities, towns and villages were decreasing to 15,859 from 71,314 by the community integration in 1888-1889. And yet, there were 61 towns and villages in Motosu county located in the hypocenter of the Nobi earthquake at the time, and there were 33,000 people. The 61 towns and villages were consisting with populations of 114 -3506, and households of 14-3508. Gifu prefecture published a disaster report on the numbers of collapsed house and casualties by the earthquake, including the populations and households on all cities, towns in a week after the earthquake. Already Muramatsu (1983) and Iida (1985) discussed the Gifu prefecture disaster report, and they calculated the collapse rate and estimated the seismic intensities in the towns and villages. However, they never discuss precisely the disaster in each city, town and village. Firstly, we make a distribution map of the completely-collapse rates of the cities, towns and villages in Gifu and Aichi prefectures using GIS software. As Muramatsu already pointed out that there are two regions over 90% of collapse rates precisely. One is located along the Neodani fault, and it is a very narrow area. The other is located wide area in north Nobi Plain. Some research groups suggest another fault named Gifu-Ichinomiya line, because the region of seismic intensity 7 is estimated from Gifu to south Nagoya. However high collapse rate over 90% is not distributed as zones. It is suggested that collapsed houses are increased by shallow ground structures such as alluvium. Surely, alluvium is distributed with thick with 50 m maximally in the region. However, more local

  1. Monitoring shallow resistivity changes prior to the 12 May 2008 M 8.0 Wenchuan earthquake on the Longmen Shan tectonic zone, China

    Science.gov (United States)

    Lu, Jun; Xie, Tao; Li, Mei; Wang, Yali; Ren, Yuexia; Gao, Shude; Wang, Lanwei; Zhao, Jialiu

    2016-04-01

    An active source measurement of shallow resistivity using fixed-electrode quasi-Schlumberger arrays has been conducted at Pixian, Jiangyou and Wudu stations on the Longmen Shan tectonic zone in western China, with the hope of detecting earthquake-associated changes. For the duration of the monitoring experiment, a gradual decrease of apparent resistivity of up to 6.7% several years prior to the 12 May 2008 M 8.0 Wenchuan earthquake had been recorded clearly at Pixian station, approximately 35 km from the epicenter. The change of apparent resistivity was monitored with a fixed Schlumberger array of AB/MN spacings of 736 m/226 m in the direction of N57.5°E, giving precisions in measured daily averages of 0.16% or less. A coseismic resistivity drop of up to 5.3% was observed at Jiangyou station, using a Schlumberger array of AB/MN spacings of 710 m/90 m in the direction of N10°E. No fluctuation of resistivity was detected at Wudu station at the time of the Wenchuan mainshock. While the focus of this paper is on monitoring or tracking resistivity variations prior to, during, and after the Wenchuan earthquake, we also aim to compare resistivity records of the Wenchuan earthquake to those of the M 7.8 Tangshan and M 7.2 Songpan earthquakes of 1976. Attempts to explain the observed resistivity variations have been made. The results show that the resistivity variations observed at all three stations are in approximate agreement with resistivity-stress behavior deduced from in situ experiments, focal mechanisms, a simplified dynamical model, static stress analyses, and field investigations from along the Longmen Shan fault zone.

  2. Rapid Seismic Deployment for Capturing Aftershocks of the September 2017 Tehuantepec, Mexico (M=8.1) and Morelos-Puebla (M=7.1), Mexico Earthquakes

    Science.gov (United States)

    Velasco, A. A.; Karplus, M. S.; Dena, O.; Gonzalez-Huizar, H.; Husker, A. L.; Perez-Campos, X.; Calo, M.; Valdes, C. M.

    2017-12-01

    The September 7 Tehuantepec, Mexico (M=8.1) and the September 19 Morelos-Puebla, Mexico (M=7.1) earthquakes ruptured with extensional faulting within the Cocos Plate at 70-km and 50-km depth, as it subducts beneath the continental North American Plate. Both earthquakes caused significant damage and loss of life. These events were followed by a M=6.1 extensional earthquake at only 10-km depth in Oaxaca on September 23, 2017. While the Morelos-Puebla earthquake was likely too far away to be statically triggered by the Tehuantepec earthquake, initial Coulomb stress analyses show that the M=6.1 event may have been an aftershock of the Tehuantepec earthquake. Many questions remain about these earthquakes, including: Did the Cocos Plate earthquakes load the upper plate, and could they possibly trigger an equal or larger earthquake on the plate interface? Are these the result of plate bending? Do the aftershocks migrate to the locked zone in the subduction zone? Why did the intermediate depth earthquakes create so much damage? Are these earthquakes linked by dynamic stresses? Is it possible that a potential slow-slip event triggered both events? To address some of these questions, we deployed 10 broadband seismometers near the epicenter of the Tehuantepec, Mexico earthquake and 51 UTEP-owned nodes (5-Hz, 3-component geophones) to record aftershocks and augment networks deployed by the Universidad Nacional Autónoma de México (UNAM). The 10 broadband instruments will be deployed for 6 months, while the nodes were deployed 25 days. The relative ease-of-deployment and larger numbers of the nodes allowed us to deploy them quickly in the area near the M=6.1 Oaxaca earthquake, just a few days after that earthquake struck. We deployed them near the heavily-damaged cities of Juchitan, Ixtaltepec, and Ixtepec as well as in Tehuantepec and Salina Cruz, Oaxaca in order to test their capabilities for site characterization and aftershock studies. This is the first test of these

  3. Ionosonde tracking of infrasound wavefronts in the thermosphere launched by seismic waves after the 2010 M8.8 Chile earthquake

    Science.gov (United States)

    Maruyama, Takashi; Yusupov, Kamil; Akchurin, Adel

    2015-04-01

    It is well known that atmospheric waves excited by intense earthquakes induce ionospheric disturbances. At remote distances greater than ~500 km, Rayleigh waves are the major source of infrasounds that propagate upward in the atmosphere. Acoustic waves interact with the ionospheric plasma through collision between neutral particles and ions. Ionospheric disturbances caused by Rayleigh waves near the low frequency part of the Airy phase (a period of several minutes) are detected as a change in the total electron content since the wavelength of induced acoustic waves in the thermosphere is comparable to the ionospheric slab thickness. On the other hand, Rayleigh waves near the high frequency part of the Airy phase (a period of several tens of seconds) cause distortion of ionogram traces characterized by a multiple cusp signature (MCS). The vertical separation of the ledge corresponding to each cusp is the wavelength of the infrasound in the thermosphere. Thus, the MCS ionogram is considered to be a snapshot of the wave that propagates upward. We conducted rapid run operation of ionosonde with a frame rate of 1 min at Kazan, Russia. After the 2010 M8.8 Chile earthquake (epicentral distance was 15,162 km), ionospheric disturbances showing MCSs on ionograms were observed for several tens of minutes. The sound speed calculated by a model was 500~700 m/s at the height of the bottomside ionosphere and wavefronts should propagate 30~42 km upward during the intervals of ionograms, which is smaller than the bottomside depth of the ionosphere. The seismogram obtained at Obninsk near Moscow, Russia (epicentral distance was 14,369 km) recorded Rayleigh waves with a period of ~17 s responsible for the ionospheric disturbances showing MCS, when the plot was shifted by the time corresponding to the difference of epicentral distances between the two locations by assuming a Rayleigh wave speed of 3 km/s. The vertical wavelength of the acoustic waves launched by the Rayleigh waves was

  4. Ground Shaking and Earthquake Engineering Aspects of the M 8.8 Chile Earthquake of 2010 - Applications to Cascadia and Other Subduction Zones (Invited)

    Science.gov (United States)

    Cassidy, J. F.; Boroschek, R.; Ventura, C.; Huffman, S.

    2010-12-01

    The M 8.8 Maule, Chile earthquake of February 27, 2010 was the fifth largest earthquake ever recorded by seismographs and provides a rare opportunity to compare strong shaking observations with earthquake rupture and damage patterns. This subduction earthquake was caused by up to 13 m of eastward slip of the Nazca plate beneath the South American plate. The rupture zone extended nearly 600 km along the Chile coast and covered the most populated region of the country - extending from south of Concepcion to just south of Valpraiso (near the latitude of Santiago). As this is the type of earthquake that is expected along the Cascadia subduction zone of western Canada and the U.S., and given that modern building codes and construction styles in Chile and Cascadia are very similar, the Canadian Association of Earthquake Engineers sent a team of 10 engineers and a seismologist to the earthquake zone to learn from this earthquake. In this presentation we focus on sites where strong ground shaking was recorded (the data available to date range from about 0.1g to 0.66g). The recorded waveforms showed strong shaking for up to 2-3 minutes, with two distinct bursts of energy that may correspond to two large asperities that ruptured. At many locations, particularly along the coast, the recorded shaking levels exceeded code values, especially at longer periods (~ 1 second and longer). There was significant damage to older hospitals and schools. Twenty-five hospitals were severely damaged (17 collapsed, 8 repairable) and in the Maule region, 45% of the hospital beds were lost. More than 2500 schools were damaged and more than 780,000 students were affected. Of about 12,000 bridges in Chile, only 40 were damaged, 20 severely (many of these were newer overpasses). Modern high-rise buildings, in general, did very well. Of the 10,000 3-storey or higher buildings constructed since 1985, only 4 collapsed, and 50-150 were badly damaged. This clearly demonstrates the importance of modern

  5. Empirical relations between the April 1, M8.2 2014 Chile earthquake and the April 16, M7.8 2016 Ecuador earthquake, and a comparison with instrumental ground motion

    Science.gov (United States)

    Cilia, M. G.; Smith, E. M.; Mooney, W. D.

    2017-12-01

    We determine empirical relationships between instrumental peak ground motions and observed intensities for two recent South American megathrust (interplate subduction) earthquakes: the April 1, 2014 M 8.2 Iquique earthquake, and the April 16, 2016 M 7.8 Ecuador earthquake. Although both earthquakes were shallow focus events (earthquake rupture plane for the 2014 Iquique event. However, the maximum MMI value reached in the 2016 Ecuador event was a VIII. The difference indicates that the earthquake magnitude is not always the defining parameter that determines the loss of life and extent of damage. Our close assessment of these two events leads us to postulate this difference is due to differences of engineering practice in these countries. It is also possible that there are regional variations in the efficiency of the radiation of high-frequency seismic waves for different subduction zones.

  6. Magnesium, calcium, and trace elements excretion in 24-h urine.

    Science.gov (United States)

    Długaszek, Maria; Kaszczuk, Mirosława; Mularczyk-Oliwa, Monika

    2011-07-01

    Urine is a clinical specimen often used in medical diagnostics for monitoring of elements concentrations and kidneys function. We determined the contents of magnesium (Mg), calcium (Ca), zinc (Zn), copper (Cu), iron (Fe), lead (Pb), and cadmium (Cd) in 74 samples of 24-h urine (from 46 women and 28 men). The measurements were realized by the atomic absorption spectrometry (AAS) with atomization in the flame (FAAS) and in the graphite furnace (GFAAS). The received results were the subject of statistical analysis including the sex and age of volunteers. Moreover, correlations between the elements and the relationships between age and amounts of excreted elements with urine were tested. We found the statistically significant higher content of Zn in men's urine than in women(')s one. Moreover, both adult women and men (>18 years) excreted much more Ca in urine in comparison to young subjects. Only in case of Pb the significant positive correlation between its amount in 24-h urine of all donors and age was stated. The correlation analysis has shown the significant positive relationships between Ca-Mg, Ca-Fe, Mg-Fe, Cu-Fe, Cu-Cd, Fe-Cd, and Pb-Cd in total samples of urine. Basing on our results, we concluded that the gender and age of donors may impact on the elemental status of 24-h urine.

  7. CT characteristics in 24 patients with POEMS syndrome.

    Science.gov (United States)

    Shi, Xiaofeng; Hu, Shudong; Luo, Xianfu; Luo, Ming; You, Haiyan; Zhu, Yan; Xi, Xiaodong

    2016-01-01

    POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M protein, and Skin changes) syndrome is a complicated and rare disease. Systematic research on computed tomography (CT) imaging characteristics in POEMS syndrome is scanty. The role of CT in diagnosis needs to be assessed. To retrospectively analyze the CT imaging features in 24 patients with POEMS syndrome and evaluate the role of CT in diagnosis of this disease. Twenty-four patients with confirmed POEMS syndrome were included in the study. Chest and abdominal CT images were analyzed. The three minor diagnostic criteria for POEMS syndrome (extravascular volume overload, organomegaly, and bone lesions) can be detected effectively by CT. Extravascular volume overload involved multiple serous cavities: hydrothorax, hydropericardium, and ascites, which were found in 79.2%, 41.7%, and 54.2% patients, respectively. The volume of effusion was small to moderate. Organomegaly involved multiorgans: hepatomegaly was found in 45.8% patients, splenomegaly in 54.2%, and lymphadenopathy in 75% patients. Hepatospleen exhibited moderate homogeneous enlargement without local enhanced signal after injection of contrast material. Bone lesions were classified into three groups: osteosclerotic, osteolytic, and mixed lesions. Osteosclerotic lesions, taking multiple, scattered, and variably sized high-density plaque-like appearance, were found in 20.8% patients. Osteolytic lesions, exhibiting punched-out low-density image, were found in 4.2% patients. Mixed ones, holding both common characteristics of them, were detected in 8.3% patients. These CT abnormalities disappeared after effective treatment. CT plays vital role in the confirmation of the three minor diagnostic criteria for POEMS syndrome: extravascular volume overload, organomegaly, and bone lesions. © The Foundation Acta Radiologica 2015.

  8. An application of earthquake prediction algorithm M8 in eastern ...

    Indian Academy of Sciences (India)

    On 23rd October 2011, an M7.3 earthquake near the Turkish city of Van, killed more than 600 people, injured over 4000, and left about 60,000 homeless. It demolished hundreds of buildings and caused great damages to thousand others in Van, Ercis, Muradiye, and Çaldıran. The earthquake's epicenter is located about 70 ...

  9. An application of earthquake prediction algorithm M8 in eastern ...

    Indian Academy of Sciences (India)

    On 23rd October 2011, an M7.3 earthquake near the Turkish city of Van, killed more than 600 people, injured over 4000, and left about 60,000 homeless. It demolished hundreds of buildings and caused great damages to thousand others in Van, Ercis, Muradiye, and C¸aldıran. The earthquake's epicenter is located about 70 ...

  10. Focused-microwave-assisted sample preparation (M8)

    International Nuclear Information System (INIS)

    Nobrega, J.A.; Santos, D.M.; Trevizan, L.C.; Costa, L.M.; Nogueira, A.R.A.

    2002-01-01

    Full text: Focused-microwave-assisted sample preparation is a suitable strategy when dealing with high masses of organic samples. However, the final acid concentration of the digestate can difficult routine analytical measurements using spectroscopic techniques. Acids could be evaporated, but this step could be slow even when using microwave-assisted heating and requires a scrubber system for acid vapor collection and neutralization. We are investigating two procedures to decrease the acid concentration of digestates. The first one is based on acid vapor phase digestion of samples contained in PTFE devices' inserted into the microwave flask. The acid solution is heated by absorption of microwave radiation, then the acid vapor partially condenses in the upper part of the reaction flask and it is partially collected in each sample container. Calcium, Fe, Mg, Mn, and Zn were quantitatively recovered in samples of animal and vegetable tissues. Better recoveries were attained when adding a small volume of sodium hypochlorite to the sample. This effect is probably related to the generation of chlorine in the sample container after collecting condensed acid. The second procedure developed is based on the gradual addition of liquid samples to a previously heated acid digestion mixture. This procedure was successfully applied for digestion of milk, fruit juices, and red wine. The main advantage is the possibility of digesting up to four-fold more sample using up to ten-fold lower amounts of concentrated acids. Results obtained using both digestion procedures and measurements by ICP-OES with axial view will be presented. (author)

  11. Multi-sensory stimulation in 24-hour dementia care: effects of snoezelen on residents and caregivers

    NARCIS (Netherlands)

    van Weert, J.; van Dulmen, S.; Bensing, J.

    2011-01-01

    Dementia among nursing home residents is oftenaccompanied by behavioural disturbances and high caredependency. Multi-Sensory Stimulation or snoezelen,integrated in 24-h dementia care, is an approach thatmight improve mood and behaviour of demented elderlyas well as the quality of working life of

  12. Multi-sensory stimulation in 24-hour dementia care: effects of snoezelen on residents and caregivers.

    NARCIS (Netherlands)

    Weert, J. van; Dulmen, S. van; Bensing, J.

    2011-01-01

    Dementia among nursing home residents is oftenaccompanied by behavioural disturbances and high caredependency. Multi-Sensory Stimulation or snoezelen,integrated in 24-h dementia care, is an approach thatmight improve mood and behaviour of demented elderlyas well as the quality of working life of

  13. Gender in children's television worldwide: Results from a media analysis in 24 countries

    NARCIS (Netherlands)

    Götz, M.; Hofmann, O.; Brosius, H.B.; Carter, C.; Chan, K.; Donald, S.H.; Fischerkeller, J.; Frenette, M.; Kolbjørnsen, T.; Lemish, D.; Lustyik, K.; McMillin, D.C.; Walma van der Molen, J.H.; Pecora, N.; Prinsloo, J.; Pestaj, M.; Ramos Rivero, P.; Mereilles Reis, A.H.; Saeys, F.; Scherr, S.; Zhang, H.

    2008-01-01

    In the world’s largest quantitative media analysis of children’s TV so far the main characters of fictional programmes in 24 countries were coded. The results show a clear under-representation and stereotyped depiction of female characters worldwide.

  14. Search for 12 C+ 12 C clustering in 24 Mg ground state

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 88; Issue 2. Search for 12C+12C clustering in 24Mg ground state. B N JOSHI ARUN K JAIN D C BISWAS B V JOHN Y K GUPTA L S DANU R P VIND G K PRAJAPATI S MUKHOPADHYAY A SAXENA. Regular Volume 88 Issue 2 February 2017 Article ID 29 ...

  15. Multi-sensory stimulation in 24-hour dementia care: effects of snoezelen on residents and caregivers.

    OpenAIRE

    Weert, J. van; Dulmen, S. van; Bensing, J.

    2011-01-01

    Dementia among nursing home residents is oftenaccompanied by behavioural disturbances and high caredependency. Multi-Sensory Stimulation or snoezelen,integrated in 24-h dementia care, is an approach thatmight improve mood and behaviour of demented elderlyas well as the quality of working life of dementiacaregivers. This book describes a study in which six intervention wards received a training program ‘snoezelen for caregivers’. They were compared with six control wards providing 'usual care'...

  16. Indoor Air Quality in 24 California Residences Designed as High-Performance Homes

    Energy Technology Data Exchange (ETDEWEB)

    Less, Brennan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Mullen, Nasim [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Singer, Brett [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Walker, Iain [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-07-01

    Today’s high performance green homes are reaching previously unheard of levels of airtightness and are using new materials, technologies and strategies, whose impacts on Indoor Air Quality (IAQ) cannot be fully anticipated from prior studies. This research study used pollutant measurements, home inspections, diagnostic testing and occupant surveys to assess IAQ in 24 new or deeply retrofitted homes designed to be high performance green buildings in California.

  17. PATTERNS OF THE MAXIMUM RAINFALL AMOUNTS REGISTERED IN 24 HOURS WITHIN THE OLTENIA PLAIN

    Directory of Open Access Journals (Sweden)

    ALINA VLĂDUŢ

    2012-03-01

    Full Text Available Patterns of the maximum rainfall amounts registered in 24 hours within the Oltenia Plain. The present study aims at rendering the main features of the maximum rainfall amounts registered in 24 h within the Oltenia Plain. We used 30-year time series (1980-2009 for seven meteorological stations. Generally, the maximum amounts in 24 h display the same pattern as the monthly mean amounts, namely higher values in the interval May-October. In terms of mean values, the highest amounts are registered in the western and northern extremity of the plain. The maximum values generally exceed 70 mm at all meteorological stations: D.T. Severin, 224 mm, July 1999; Slatina, 104.8 mm, August 2002; Caracal, 92.2 m, July 1991; Bechet, 80.8 mm, July 2006; Craiova, 77.6 mm, April 2003. During the cold season, there was noticed a greater uniformity all over the plain, due to the cyclonic origin of rainfalls compared to the warm season, when thermal convection is quite active and it triggers local showers. In order to better emphasize the peculiarities of this parameter, we have calculated the frequency on different value classes (eight classes, as well as the probability of appearance of different amounts. Thus, it resulted that the highest frequency (25-35% is held by the first two classes of values (0-10 mm; 10.1-20 mm. The lowest frequency is registered in case of the amounts of more than 100 mm, which generally display a probability of occurrence of less than 1% and only in the western and eastern extremities of the plain.

  18. Reference intervals for 24 laboratory parameters determined in 24-hour urine collections.

    Science.gov (United States)

    Curcio, Raffaele; Stettler, Helen; Suter, Paolo M; Aksözen, Jasmin Barman; Saleh, Lanja; Spanaus, Katharina; Bochud, Murielle; Minder, Elisabeth; von Eckardstein, Arnold

    2016-01-01

    Reference intervals for many laboratory parameters determined in 24-h urine collections are either not publicly available or based on small numbers, not sex specific or not from a representative sample. Osmolality and concentrations or enzymatic activities of sodium, potassium, chloride, glucose, creatinine, citrate, cortisol, pancreatic α-amylase, total protein, albumin, transferrin, immunoglobulin G, α1-microglobulin, α2-macroglobulin, as well as porphyrins and their precursors (δ-aminolevulinic acid and porphobilinogen) were determined in 241 24-h urine samples of a population-based cohort of asymptomatic adults (121 men and 120 women). For 16 of these 24 parameters creatinine-normalized ratios were calculated based on 24-h urine creatinine. The reference intervals for these parameters were calculated according to the CLSI C28-A3 statistical guidelines. By contrast to most published reference intervals, which do not stratify for sex, reference intervals of 12 of 24 laboratory parameters in 24-h urine collections and of eight of 16 parameters as creatinine-normalized ratios differed significantly between men and women. For six parameters calculated as 24-h urine excretion and four parameters calculated as creatinine-normalized ratios no reference intervals had been published before. For some parameters we found significant and relevant deviations from previously reported reference intervals, most notably for 24-h urine cortisol in women. Ten 24-h urine parameters showed weak or moderate sex-specific correlations with age. By applying up-to-date analytical methods and clinical chemistry analyzers to 24-h urine collections from a large population-based cohort we provide as yet the most comprehensive set of sex-specific reference intervals calculated according to CLSI guidelines for parameters determined in 24-h urine collections.

  19. The art of staying tuned in real-time. Remediation in 24.

    Directory of Open Access Journals (Sweden)

    Bo Kampmann Walther

    2003-01-01

    Full Text Available This article examines and discusses current media strategies in 24 Hours. Elements from interface design, computer games, canonized TV-series, reality-TV, on-line multiplayer games, fandom on the web, etc. are all part of the implicit as well as explicit familiarity and subject matter of 24. Thus, 24 becomes a unique case in point of present day remediation and transmediation. While the former plots the actualisation of historic media into contemporary hybrid genres and expressions, the latter paws the way for media forms that continuously and rapidly communicate with each other. Hereby, the study of 24 calls for new and flexible analytical tools and readings of cultural consumption. In addition, the article investigates how such apparently abstract concepts like contingency, conspiracy, and temporality are dramatized in Fox Network's 24.

  20. Giant quadrupole resonance in 24Mg, 27Al, and 28Si

    International Nuclear Information System (INIS)

    Youngblood, D.H.; Rozsa, C.M.; Moss, J.M.; Brown, D.R.; Bronson, J.D.

    1977-01-01

    The giant-resonance region of 24 Mg, 27 Al, and 28 Si was studied by inelastic scattering of 126-MeV α particles. In contrast to results at 96 MeV, considerable clustering of E2 strength was observed for 27 Al at E/sub x/ approx. 20.1 MeV with GAMMA approx. 7.6 MeV exhausting about 35% of the E2 energy weighted sum rule. E2 strength was also located in 24 Mg in two clusters of states at E-bar/sub x/ approx. 18.2, 24.4 MeV; however, contributions from other multipoles cannot be neglected. In 28 Si a multipeaked group was observed at E/sub x/ approx. 19.4 MeV with GAMMA approx. 4 MeV but no L assignment was made. The energy dependence of the cross section for the giant quadrupole resonance was found to be consistent with distorted-wave Born approximation predictions

  1. A Compute Perspective: Delivering Decision Support Products in 24 Hours from the Airborne Snow Observatory

    Science.gov (United States)

    Ramirez, P.; Mattmann, C. A.; Painter, T. H.; Seidel, F. C.; Trangsrud, A.; Hart, A. F.; Goodale, C. E.; Boardman, J. W.; Heneghan, C.; Verma, R.; Khudikyan, S.; Boustani, M.; Zimdars, P. A.; Horn, J.; Neely, S.

    2013-12-01

    The JPL Airborne Snow Observatory (ASO) must process 100s of GB of raw data to 100s of Terabytes of derived data in 24 hour Near Real Time (NRT) latency in a geographically distributed mobile compute and data-intensive processing setting. ASO provides meaningful information to water resource managers in the Western US letting them know how much water to maintain; or release, and what the prospectus of the current snow season is in the Sierra Nevadas. Providing decision support products processed from airborne data in a 24 hour timeframe is an emergent field and required the team to develop a novel solution as this process is typically done over months. We've constructed a system that combines Apache OODT; with Apache Tika; with the Interactive Data Analysis (IDL)/ENVI programming environment to rapidly and unobtrusively generate, distribute and archive ASO data as soon as the plane lands near Mammoth Lakes, CA. Our system is flexible, underwent several redeployments and reconfigurations, and delivered this critical information to stakeholders during the recent "Snow On" campaign March 2013 - June 2013. This talk will take you through a day in the life of the compute team from data acquisition, delivery, processing, and dissemination. Within this context, we will discuss the architecture of ASO; the open source software we used; the data we stored; and how it was delivered to its users. Moreover we will discuss the logistics, system engineering, and staffing that went into the developing, deployment, and operation of the mobile compute system.

  2. Effects of pesticides monitored with three sampling methods in 24 sites on macroinvertebrates and microorganisms.

    Science.gov (United States)

    Schäfer, Ralf B; Pettigrove, Vincent; Rose, Gavin; Allinson, Graeme; Wightwick, Adam; von der Ohe, Peter C; Shimeta, Jeff; Kühne, Ralph; Kefford, Ben J

    2011-02-15

    Grab water samples, sediment samples, and 2,2,4-trimethylpentane passive samplers (TRIMPS) were used to determine the exposure to 97 pesticides in 24 southeast Australian stream sites over 5 months. Macroinvertebrate communities and selected microorganisms (bacteria, flagellates, ciliates, amoebas, nematodes, and gastrotrichs) were sampled to detect relationships with pesticide toxicity. Sediment samples had the highest estimated toxicities in terms of toxic units (TU) for Daphnia magna (TUDM) and for Selenastrum capricornutum (TUSC). The pesticide-selective SPEARpesticides and the general SIGNAL index for macroinvertebrates exhibited negative linear relationships (r(2) = 0.67 and 0.36, respectively) with pesticide contamination in terms of log maximum TUDM (log mTUDM), suggesting macroinvertebrate community change due to pesticide exposure. Pesticide contamination was the only measured variable explaining variation in ecological quality. Variation in the densities of several microbial groups was best explained by environmental variables other than log TUs. The log mTUDM values derived from sediment concentrations were most important to establish a link with effects on macroinvertebrates, whereas log mTUDM of grab water samples had only minor contribution. Current-use insecticides and fungicides can affect macroinvertebrate communities and monitoring of sediment and continuous water sampling is needed to detect these effects.

  3. Diastolic blood pressure variability in 24 hour-ABPM and outcomes of chronic kidney disease
.

    Science.gov (United States)

    Sahutoglu, Tuncay; Sakaci, Tamer

    2018-04-10

    Blood pressure variability (BPV) has been associated with increased morbidity and mortality. There are a few studies that reported worse outcomes of chronic kidney disease (CKD) with greater visit-to-visit BPV (VVV), but data with ambulatory blood pressure monitoring (ABPM) is scarce. Ambulatory hypertensive CKD (stage 2 - 4) patients (> 18 years old) with complete 24 hours of ABPM study (SpaceLabs), who were followed up between January 2012 and December 2016, were retrospectively analyzed for the baseline characteristics and outcomes of CKD. Coefficient of variation (CV) in diastolic blood pressure (DBP) was used as an index of BPV. Data of 191 patients (mean age 59.7 ± 12.4 years, 54.9% males, 42.1% diabetic, mean eGFR-EPI (Chronic Kidney Disease Epidemiology Collaboration) 51.7 ± 22.0 mL/min/1.73m2, mean follow-up 26.2 ± 10.4 months) were available for the analysis. On multivariate linear regression analysis, greater DBP-CV was associated with slower decline in eGFR-EPI per year (B -0.648, p = 0.000). Likewise, the hazard ratio (HR) for dialysis inception (occurred in 9.4%) was found significantly lower with increasing DBP-CV in unadjusted and fully adjusted Cox models (HR 0.730, 95% CI 0.618 - 0.861, p = 0.000, and HR 0.678, 95% CI 0.526 - 0.874, p = 0.003, respectively). These findings suggest that DBP variability in 24-hour ABPM may be a good prognostic factor for the outcomes of CKD. Further studies are needed to determine the impact of 24-hour ABPM BPV on CKD progression and its differences from VVV.
.

  4. Pharmacokinetics of germanium after po beta-carboxyethylgermanium sesquioxide in 24 Chinese volunteers.

    Science.gov (United States)

    Long, Q C; Zeng, G X; Zhao, X L

    1996-09-01

    To compare the pharmacokinetics after po different doses of beta-carboxyethylgermanium sesquioxide (Ge-132). An atomic absorption spectrophotometric system was used to measure germanium concentrations in plasma and urine samples after po Ge-132 1 (low dose, LD), 2.5 (medium dose, MD), and 4 (high dose, HD) g.m-2 in 24 healthy volunteers (one dose per 8 subjects). T1/2 alpha (LD, 1.2 +/- 0.7 h; MD, 1.1 +/- 0.6 h; HD, 1.2 +/- 0.5 h), T1/2 beta (LD, 5.2 +/- 1.2 h; MD, 5.8 +/- 2.5 h; HD, 5.5 +/- 1.4 h) and Cl/F (LD, 33 +/- 12 L.h-1; MD, 35 +/- 10 L.h-1; HD, 33 +/- 11 L.h-1) were not dose-related. Tmax was between 0.75 h and 2 h. Cmax (LD, 5.3 +/- 2.2 mg.L-1; MD, 13 +/- 5 mg.L-1; HD 18 +/- 8 mg.L-1, HD) and AUC (LD, 31 +/- 13 mg.h.L-1; MD, 60 +/- 16 mg.h.L-1; HD, 79 +/- 42 mg.h.L-1) were positive correlation to the dose of Ge-132. Urine-eliminated germanium within 24 h accounted for 11 +/- 3% of LD, 9 +/- 3% of MD, and 6 +/- 5% of HD (calculated from Ge/F) and showed a negative correlation to the dose. 1) Intracorporal process of Ge after po Ge-132 coincided with the first-order absorption and elimination with two-compartment kinetic model; 2) The amount of germanium eliminated in urine was below 11%.

  5. Difference in 24-Hour Urine Composition between Diabetic and Non-Diabetic Adults without Nephrolithiasis.

    Directory of Open Access Journals (Sweden)

    Wei Zhu

    Full Text Available Diabetic patients are more likely to develop kidney stones than the general population. The underlying mechanisms for this disparity remain to be elucidated. Little is known about the relationship between urine composition and diabetes mellitus in non-stone-forming individuals. We sought to examine the differences in the 24-hour (24-h urine composition between diabetic and non-diabetic adults who were not stone formers.A convenience sample of 538 individuals without a history of nephrolithiasis, gout, hyperparathyroidism, or gastroenteric diseases participated in this study. The 24-h urine profiles of 115 diabetic adults were compared with those of 423 non-diabetic adults. Diabetes was defined by self-reported physician diagnosis or medication use. All participants were non-stone formers confirmed by urinary tract ultrasonography. Participants provided a fasting blood sample and a single 24-h urine collection for stone risk analysis. Student's t-test was used to compare mean urinary values. Linear regression models were adjusted for age, gender, body mass index, hypertension, fasting serum glucose, serum total cholesterol, estimated creatinine clearance rate and urinary factors.Univariable analysis showed that the diabetic participants had significantly higher 24-h urine volumes and lower urine calcium and magnesium excretions than non-diabetic participants (all P 0.05. The main limitation of this study is that the convenience samples and self-reported data may have been sources of bias.Our data showed that there were no differences in 24-h urine composition between diabetic and non-diabetic adults who are not stone formers. The reason for it might be the improved glycemic control in diabetic individuals in our study. Therefore, a tighter glycemic control might reduce stone formation in diabetic adults.

  6. Cobalt Chrome Spinal Constructs Trigger Airport Security Screening in 24% of Pediatric Patients.

    Science.gov (United States)

    Woon, Regina P; Andras, Lindsay M; Barrett, Kody K; Skaggs, David L

    2015-03-01

    Retrospective study. To determine whether pediatric patients undergo additional airport security screening after posterior spinal fusion. Airport security has expanded to include body scanners as well as traditional metal detectors. Families frequently ask whether spinal implants will trigger airport security, but there is limited information on modern implants and screening methods. The researchers conducted a survey of 50 pediatric patients after posterior spinal fusion from 2004 to 2013. Inclusion criteria were posterior instrumentation, pedicle screws for at least 80% of anchors, and at least 1 trip through an American airport after surgery. Charts and radiographs were reviewed for metal type, number of levels fused, number of anchors, and rod diameter. A total of 16% of patients (8 of 50) were detected by body scan or metal detector and all had cobalt chrome (CoCr) rods. No patients with stainless-steel (SS) rods were detected. The CoCr rods triggered additional screening in 24% of children (8 of 33), compared with none of 17 with SS rods (p = .03). For patients with CoCr rods, the detection rate was 18% (5 of 28) by metal detector and 17% (3 of 18) by body scanner. For patients with CoCr rods, there was no significant difference between detection rates and levels fused (p = .30), number of anchors (p = .15), or rod diameter (p = .17). In this series, CoCr constructs were more likely to incur additional airport security compared with more traditional SS constructs. Copyright © 2015 Scoliosis Research Society. Published by Elsevier Inc. All rights reserved.

  7. Parabens in 24 h urine samples of the German Environmental Specimen Bank from 1995 to 2012.

    Science.gov (United States)

    Moos, Rebecca K; Koch, Holger M; Angerer, Jürgen; Apel, Petra; Schröter-Kermani, Christa; Brüning, Thomas; Kolossa-Gehring, Marike

    2015-10-01

    Parabens are widely used as antimicrobial preservatives in personal care and consumer products, food and pharmaceuticals. Due to their ubiquity, humans are constantly exposed to these chemicals. We assessed exposure to nine parabens (methyl-, ethyl-, n- and iso-propyl-, n- and iso-butyl-, benzyl-, pentyl- and heptyl paraben) in the German population from 1995 to 2012 based on 660 24h urine samples from the German Environmental Specimen Bank (ESB) using on-line HPLC coupled to isotope dilution tandem mass spectrometry. The limit of quantification (LOQ) was 0.5 μg/L for all parabens. We detected methyl-, ethyl- and n-propyl paraben in 79-99% of samples, followed by n-butyl paraben in 40% of samples. We infrequently detected iso-butyl-, iso-propyl- and benzyl paraben in 24%, 4% and 1.4% of samples, respectively. Urinary concentrations were highest for methyl paraben (median 39.8 μg/L; 95th percentile 319 μg/L) followed by n-propyl paraben (4.8 μg/L; 95th percentile 74.0 μg/L) and ethyl paraben (2.1 μg/L; 95th percentile 39.1 μg/L). Women had significantly higher urinary levels for all parabens than men, except for benzyl paraben. Samples from the ESB revealed that over the investigation period of nearly 20 years urinary paraben levels remained surprisingly constant; only methyl paraben had a significant increase, for both men and women. We found strong correlations between methyl- and n-propyl paraben and between n- and iso-butyl paraben. These results indicate that parabens are used in combination and arise from common sources of exposure. Urinary excretion factors are needed to extrapolate from individual urinary concentrations to actual doses. Copyright © 2015 Elsevier GmbH. All rights reserved.

  8. Bike Score®: Associations between urban bikeability and cycling behavior in 24 cities.

    Science.gov (United States)

    Winters, Meghan; Teschke, Kay; Brauer, Michael; Fuller, Daniel

    2016-02-11

    There is growing interest in designing cities that support not only walking, but also cycling. Bike Score® is a metric capturing environmental characteristics associated with cycling that is now available for over 160 US and Canadian cities. Our aim was to determine if Bike Score was associated with between and within-city variability in cycling behavior. We used linear regression to model associations between Bike Score and journey to work cycling mode share (US: American Community Survey, 2013 or 2012 5-year estimates; Canada: 2011 National Household Survey) for 5664 census tracts in 24 US and Canadian cities. At the city level, the correlation between mean Bike Score and mean journey to work cycling mode share was moderate (r = 0.52). At the census tract level, the correlation was 0.35; a ten-unit increase in Bike Score was associated with a 0.5% (95% CI: 0.5 to 0.6) increase in the proportion of population cycling to work, a meaningful difference given the low modal shares (mean = 1.9%) in many North American cities. Census tracts with the highest Bike Scores (>90 to 100) had mode shares 4.0 higher (β = 4.0, 95% CI: 2.9 to 5.0) than the lowest Bike Score areas (0-25). City specific analyses indicated between-city variability in associations, with regression estimates between Bike Score and mode share ranging from 0.2 to 3.5%. The Bike Score metric was associated bicycle mode share between and within cities, suggesting its utility for planning bicycle infrastructure.

  9. Transarterial embolisation of renal arteriovenous malformation: safety and efficacy in 24 patients with follow-up

    International Nuclear Information System (INIS)

    Eom, H.-J.; Shin, J.H.; Cho, Y.J.; Nam, D.H.; Ko, G.-Y.; Yoon, H.-K.

    2015-01-01

    Aim: To evaluate the efficacy and safety of renal artery embolisation (RAE) for renal arteriovenous malformation (AVM) as well as its outcomes. Materials and methods: The technical and clinical success rates, radiological and laboratory findings, and complications of RAE for 31 renal AVMs in 24 patients (M:F=9:15, mean age 46 years) at two separate medical institutions were retrospectively evaluated. Technical success was defined as complete occlusion of feeding arteries with no residual nidus seen on post-treatment angiography. Clinical failure was defined as recurrence of haematuria, presence of AVM on follow-up ultrasound or computed tomography, repeated RAE or surgery for the control of haematuria. Overall clinical success was defined as resolution haematuria or disappearance of AVM on follow-up imaging after single or multiple sessions of RAE. Results: Types of renal AVM were AVM, arterio-venous fistula (AVF) with intranidal aneurysm, and acquired AVF in 19, 1, and 4 patients, respectively. 18 patients (75%) underwent a single session of RAE, while 6 patients (25%) had two or more sessions of RAE. The level of embolisation was feeder, segmental artery, and main renal artery in 28 (90%), 2 (6%), and 1 (4%) procedures, respectively. Coil, n-butyl 2-cyanoacrylate, and polyvinyl alcohol were the most frequently chosen embolic materials and were used in 19, 14, and 8 procedures, respectively. The clinical success rate after initial RAE was 67% (16/24). Overall clinical success rate, including multisession RAE, was 88% (21/24). The technical success rate of 31 procedures was 65% (20/31). Among 11 technical failures in 10 patients, 4 achieved clinical success without additional RAE, 3 underwent second session RAE to achieve clinical success, and 3 patients underwent nephrectomy due to recurrence. Conclusion: RAE is a safe and effective treatment for renal AVM. Technical failure of RAE does not always lead to clinical failure and multiple embolisation sessions may be

  10. Indoor air quality in 24 California residences designed as high-performance homes

    Energy Technology Data Exchange (ETDEWEB)

    Less, Brennan [Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Mullen, Nasim [Gap, Inc., San Francisco, CA (United States); Singer, Brett [Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Walker, Iain [Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

    2015-01-01

    Today’s high performance green homes are reaching previously unheard of levels of airtightness and are using new materials, technologies and strategies, whose impacts on Indoor Air Quality (IAQ) cannot be fully anticipated from prior studies. This research study used pollutant measurements, home inspections, diagnostic testing and occupant surveys to assess IAQ in 24 new or deeply retrofitted homes designed to be high performance green buildings in California. Although the mechanically vented homes were six times as airtight as non-mechanically ventilated homes (medians of 1.1 and 6.1 ACH50, n=11 and n=8, respectively), their use of mechanical ventilation systems and possibly window operation meant their median air exchange rates were almost the same (0.30 versus 0.32 hr-1, n=8 and n=8, respectively). Pollutant levels were also similar in vented and unvented homes. In addition, these similarities were achieved despite numerous observed faults in complex mechanical ventilation systems. More rigorous commissioning is still recommended. Cooking exhaust systems were used inconsistently and several suffered from design flaws. Failure to follow best practices led to IAQ problems in some cases. Ambient nitrogen dioxide standards were exceeded or nearly so in four homes that either used gas ranges with standing pilots, or in Passive House-style homes that used gas cooking burners without venting range hoods. Homes without active particle filtration had particle count concentrations approximately double those in homes with enhanced filtration. The majority of homes reported using low-emitting materials; consistent with this, formaldehyde levels were approximately half those in conventional, new CA homes built before 2008. Emissions of ultrafine particles (with diameters <100 nm) were dramatically lower on induction electric cooktops, compared with either gas or resistance electric models. These results indicate that high performance homes can achieve

  11. Gender differences in 24-hour outcome following resuscitation after 9 minutes of cardiac arrest in dogs.

    Science.gov (United States)

    Zwemer, C F; O'Connor, E M; Whitesall, S E; D'Alecy, L G

    1997-02-01

    To examine possible gender-specific differences in 24-hr outcome following resuscitation from 9 mins of controlled cardiac arrest. Preclinical, prospective study comparing two similarly prepared, independent control groups (one female group, one male group) included in a larger series of studies. Physiology research laboratory at a major medical center. Male and female mongrel dogs (Canis familiaris), weighing 16 to 22 kg. Cardiopulmonary-cerebral resuscitation following 9 mins of normothermic cardiac arrest in male vs. female dogs. Mean arterial blood pressure, heart rate, urine output, arterial blood oxygen, and PCO2 values, arterial pH, temperature, plasma glucose concentrations, and hematocrit were measured and recorded at the precardiac arrest and postcardiac arrest period, and at 30 mins, and 1, 4, 6, 12, and 24 hrs following resuscitation. Neurologic dysfunction was assessed using a well-standardized neurologic deficit score assigned at 6, 12, and 24 hrs after arrest. Plasma concentrations of malonaldehyde, 4-hydroxynonenal, and erythrocyte-reduced glutathione were measured at the precardiac arrest period, and 6, 12, and 24 hrs following resuscitation. Additionally, serum concentrations of alanine aminotransferase, aspartate aminotransferase, total bilirubin, alkaline phosphatase, gamma-glutamyl transferase, creatinine kinase, creatinine, albumin, and total protein were measured before arrest, and at 6, 12, and 24 hrs after resuscitation. Plasma concentrations of inorganic phosphorus, blood urea nitrogen, and electrolytes (sodium, chloride, calcium, and potassium) were measured. The estrous cycle phase in the female dogs enrolled in the study was determined by physical examination and vaginal cytology. No prearrest differences were detectable between males and females in basic physiologic variables. No differences in neurologic deficit were detectable between males and females across the 24-hr recovery period following resuscitation. No detectable

  12. Student financial support. An inventory in 24 European countries. Background report for the project on portability of student financial support

    NARCIS (Netherlands)

    Vossensteyn, Johan J.

    2004-01-01

    This report provides a description of the current national systems of student financial support in 24 European countries. It provides information on tuition fees, grants, scholarships, student loans, and indirect student support through students families (family allowances and tax benefits) and

  13. Surface and canopy fuels vary widely in 24-yr old postfire lodgepole pine forests

    Science.gov (United States)

    Nelson, K. N.; Turner, M.; Romme, W. H.; Tinker, D. B.

    2013-12-01

    Extreme fire seasons have become common in western North America, and the extent of young postfire forests has grown as fire frequency and annual area burned have increased. These young forests will set the stage for future fires, but an assessment of fuel loads in young forests is lacking. The rate of fuel re-accumulation and fuels variability in postfire forest landscapes is needed to anticipate future fire occurrence and behavior in the American West. We studied fuel characteristics in young lodgepole pine forests that regenerated after the 1988 fires in Yellowstone National Park to address two questions: (1) How do surface fuel characteristics change with time-since-fire? (2) How do canopy and surface fuels vary across the Yellowstone landscape 24 years postfire? During summer 2012, we re-measured surface fuels in 11 plots that were established in 1996 (8 yrs post fire), and we measured surface and canopy fuels in 82 stands (each 0.25 ha) distributed across the Yellowstone post-1988 fire landscape. In the remeasured plots, surface fuel loads generally increased over the last 16 years. One-hr fuels did not change between sample dates, but all other fuel classes (i.e., 10-hr, 100-hr, and 1000-hr) increased by a factor of two or three. Within the sample timeframe, variability of fuel loads within stands decreased significantly. The coefficients of variation decreased for all fuel classes by 23% to 67%. Data from the 82 plots revealed that canopy and surface fuels in 24-year-old stands varied tremendously across the Yellowstone landscape. Live tree densities spanned 0 to 344,067 trees ha-1, producing a mean available canopy fuel load of 7.7 Mg ha-1 and a wide range from 0 to 47 Mg ha-1. Total surface fuel loads averaged 130 Mg ha-1 and ranged from 49 to 229 Mg ha-1, of which 90% was in the 1000-hr fuel class. The mass of fine surface fuels (i.e., litter/duff, 1-hr, 10-hr, and herbaceous fuels) and canopy fuels (i.e., foliage and 1-hr branches) were strongly and

  14. Testing the Relationships between Energy Consumption, CO2 emissions and Economic Growth in 24 African Countries: a Panel ARDL Approach

    OpenAIRE

    Simplice Asongu; Ghassen El Montasser; Hassen Toumi

    2015-01-01

    This study complements existing literature by examining the nexus between energy consumption (EC), CO2 emissions (CE) and economic growth (GDP) in 24 African countries using a panel ARDL approach. The following findings are established. First, there is a long run relationship between EC, CE and GDP. Second, a long term effect from CE to GDP and EC is apparent, with reciprocal paths. Third, the error correction mechanisms are consistently stable. However, in cases of disequilibrium only EC can...

  15. Sex differences in 24-hour ultra-marathon performance - A retrospective data analysis from 1977 to 2012

    Directory of Open Access Journals (Sweden)

    Laura Peter

    2014-01-01

    Full Text Available OBJECTIVES: This study examined the changes in running performance and the sex differences between women and men in 24-hour ultra-marathons held worldwide from 1977 to 2012. METHOD: Changes in running speed and ages of the fastest 24-hour ultra-marathoners were determined using single- and multi-level regression analyses. RESULTS: From 1977 to 2012, the sex differences in 24-hour ultra-marathon performance were 4.6±0.5% for all women and men, 13.3% for the annual fastest finishers, 12.9±0.8% for the top 10 and 12.2±0.4% for the top 100 finishers. Over time, the sex differences decreased for the annual fastest finishers to 17%, for the annual 10 fastest finishers to 11.3±2.2% and for the annual 100 fastest finishers to 14.2±1.8%. For the annual fastest men, the age of peak running speed increased from 23 years (1977 to 53 years (2012. For the annual 10 and 100 fastest men, the ages of peak running speed were unchanged at 40.9±2.5 and 44.4±1.1 years, respectively. For women, the ages of the annual fastest, the annual 10 fastest and the annual 100 fastest remained unchanged at 43.0±6.1, 43.2±2.6 and 43.8±0.8 years, respectively. CONCLUSION: The gap between the annual top, annual top 10 and annual top 100 female and male 24-hour ultra-marathoners decreased over the last 35 years; however, it seems unlikely that women will outrun men in 24-hour ultra-marathons in the near future. The fastest 24-hour ultra-marathoners worldwide achieved their peak performance at the age of master athletes (>35 years.

  16. Comparison of calcium, magnesium, sodium, potassium, zinc, and creatinine concentration in 24-h and spot urine samples in women.

    Science.gov (United States)

    Ilich, Jasminka Z; Blanusa, Maja; Orlić, Zeljka Crncević; Orct, Tatjana; Kostial, Krista

    2009-01-01

    The 24-h urine sample is considered as the most reliable material for testing many but not necessarily all constituents in urine. However, its collection is tedious for both patients and research participants. The aim of this study was to compare concentrations of essential elements calcium (Ca), magnesium (Mg), sodium (Na), potassium (K), and zinc (Zn) in 24-h and spot urine samples. Urine samples were collected from 143 generally healthy women, aged 30-79 years. Fasting spot urine was collected immediately after the end of the 24-h collection, therefore being of the same content as the first morning urine which ended the 24-h collection. Elements were analyzed by flame atomic absorption/emission spectrometry and expressed as mg/g and/or mmol/mol of creatinine (Cr). Spearman rank order correlations between 24-h and spot urine were carried out for each element. Ratios of elements in 24-h to spot urine samples were calculated to estimate the element-proportion of spot in the 24-h sample. All coefficients of correlation between 24-h and spot urine of measured elements and Cr were significant (purine samples for each element (except K) were similar and close to 2, indicating uniform proportion of elements from spot urine sample in the 24-h sample. In addition, a high correlation between various pairs of elements was obtained in both 24-h and spot urine; the highest being between Na/Ca (0.435) and (0.578), respectively. This is in accordance with theoretical presumptions and previous findings regarding those relationships. Although replacing burdensome 24-h urine collection with spot urine sampling might not provide the solution in all cases, our results show that for the elements analyzed, spot urine could be a reliable alternative.

  17. MODIST_L3m_8D_PAR_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  18. MODIST_L3m_8D_RRS_aot_4km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  19. MODIST_L3m_8D_RRS_4km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  20. MODISA_L3m_8D_RRS_4km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  1. MODIST_L3m_8D_CDOM_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  2. OCTS_L3m_8D_RRS_angstrom_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — On August 17, 1996, the Japanese Space Agency (NASDA - National Space Development Agency) launched the Advanced Earth Observing Satellite (ADEOS). ADEOS was in a...

  3. OCTS_L3m_8D_IOP_aph_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — On August 17, 1996, the Japanese Space Agency (NASDA - National Space Development Agency) launched the Advanced Earth Observing Satellite (ADEOS). ADEOS was in a...

  4. OCTS_L3m_8D_RRS_aot_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — On August 17, 1996, the Japanese Space Agency (NASDA - National Space Development Agency) launched the Advanced Earth Observing Satellite (ADEOS). ADEOS was in a...

  5. OCTS_L3m_8D_PIC_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — On August 17, 1996, the Japanese Space Agency (NASDA - National Space Development Agency) launched the Advanced Earth Observing Satellite (ADEOS). ADEOS was in a...

  6. OCTS_L3m_8D_RRS_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — On August 17, 1996, the Japanese Space Agency (NASDA - National Space Development Agency) launched the Advanced Earth Observing Satellite (ADEOS). ADEOS was in a...

  7. OCTS_L3m_8D_IOP_a_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — On August 17, 1996, the Japanese Space Agency (NASDA - National Space Development Agency) launched the Advanced Earth Observing Satellite (ADEOS). ADEOS was in a...

  8. Meteorology, Macrophysics, Microphysics, Microwaves, and Mesoscale Modeling of Mediterranean Mountain Storms: The M8 Laboratory

    Science.gov (United States)

    Starr, David O. (Technical Monitor); Smith, Eric A.

    2002-01-01

    Comprehensive understanding of the microphysical nature of Mediterranean storms can be accomplished by a combination of in situ meteorological data analysis and radar-passive microwave data analysis, effectively integrated with numerical modeling studies at various scales, from synoptic scale down through the mesoscale, the cloud macrophysical scale, and ultimately the cloud microphysical scale. The microphysical properties of and their controls on severe storms are intrinsically related to meteorological processes under which storms have evolved, processes which eventually select and control the dominant microphysical properties themselves. This involves intense convective development, stratiform decay, orographic lifting, and sloped frontal lifting processes, as well as the associated vertical motions and thermodynamical instabilities governing physical processes that affect details of the size distributions and fall rates of the various types of hydrometeors found within the storm environment. Insofar as hazardous Mediterranean storms, highlighted in this study by three mountain storms producing damaging floods in northern Italy between 1992 and 2000, developing a comprehensive microphysical interpretation requires an understanding of the multiple phases of storm evolution and the heterogeneous nature of precipitation fields within a storm domain. This involves convective development, stratiform transition and decay, orographic lifting, and sloped frontal lifting processes. This also involves vertical motions and thermodynamical instabilities governing physical processes that determine details of the liquid/ice water contents, size disi:ributions, and fall rates of the various modes of hydrometeors found within hazardous storm environments.

  9. MODIST_L3m_8D_nFLH_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  10. MODIST_L3m_8D_SST_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  11. OCTS_L3m_8D_CHL_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — On August 17, 1996, the Japanese Space Agency (NASDA - National Space Development Agency) launched the Advanced Earth Observing Satellite (ADEOS). ADEOS was in a...

  12. MODIST_L3m_8D_RRS_angstrom_4km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  13. MODIST_L3m_8D_CHL_chlor_a_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  14. MODIST_L3m_8D_PAR_4km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  15. A Self-Assembled Electro-Active M8L4 Cage Based on Tetrathiafulvalene Ligands

    Directory of Open Access Journals (Sweden)

    Sébastien Goeb

    2014-01-01

    Full Text Available Two self-assembled redox-active cages are presented. They are obtained by coordination-driven self-assembly of a tetra-pyridile tetrathiafulvalene ligand with cis-M(dppf(OTf2 (M = Pd or Pt; dppf = 1,1′-bis(diphenylphosphinoferrocene; OTf = trifluoromethane-sulfonate complexes. Both species are fully characterized and are constituted of 12 electro-active subunits that can be reversibly oxidized.

  16. SeaWiFS_L3m_8D_RRS_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — The SeaWiFS instrument was launched by Orbital Sciences Corporation on the OrbView-2 (a.k.a. SeaStar) satellite in August 1997, and collected data from September...

  17. SeaWiFS_L3m_8D_KD490_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — The SeaWiFS instrument was launched by Orbital Sciences Corporation on the OrbView-2 (a.k.a. SeaStar) satellite in August 1997, and collected data from September...

  18. SeaWiFS_L3m_8D_POC_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — The SeaWiFS instrument was launched by Orbital Sciences Corporation on the OrbView-2 (a.k.a. SeaStar) satellite in August 1997, and collected data from September...

  19. MODISA_L3m_8D_SST4_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  20. SEAFP cooling system design. Task M8 - water coolant option (final report)

    International Nuclear Information System (INIS)

    Stubley, P.; Natalizio, A.

    1994-01-01

    This report contains the ex-vessel portions of the outline designs for first wall, blanket and divertor cooling using water as the heat transport fluid. Equipment layout, key components and main system parameters are also described. (author). 7 tabs., 14 figs

  1. MODIST_L3m_8D_RRS_aot_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  2. CZCS_L3m_8D_KD490_4km

    Data.gov (United States)

    National Aeronautics and Space Administration — The Coastal Zone Color Scanner Experiment (CZCS) was the first instrument devoted to the measurement of ocean color and flown on a spacecraft. Although other...

  3. OCTS_L3m_8D_POC_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — On August 17, 1996, the Japanese Space Agency (NASDA - National Space Development Agency) launched the Advanced Earth Observing Satellite (ADEOS). ADEOS was in a...

  4. OCTS_L3m_8D_IOP_adg_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — On August 17, 1996, the Japanese Space Agency (NASDA - National Space Development Agency) launched the Advanced Earth Observing Satellite (ADEOS). ADEOS was in a...

  5. OCTS_L3m_8D_CHL_chlor_a_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — On August 17, 1996, the Japanese Space Agency (NASDA - National Space Development Agency) launched the Advanced Earth Observing Satellite (ADEOS). ADEOS was in a...

  6. MODIST_L3m_8D_NSST_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  7. MODISA_L3m_8D_RRS_aot_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  8. MODIST_L3m_8D_PIC_4km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  9. MODISA_L3m_8D_CDOM_4km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  10. MODISA_L3m_8D_SST_9km

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS (or Moderate Resolution Imaging Spectroradiometer) is a key instrument aboard the Terra (EOS AM) and Aqua (EOS PM) satellites. Terra's orbit around the Earth...

  11. Testing the relationships between energy consumption, CO2 emissions, and economic growth in 24 African countries: a panel ARDL approach.

    Science.gov (United States)

    Asongu, Simplice; El Montasser, Ghassen; Toumi, Hassen

    2016-04-01

    This study complements existing literature by examining the nexus between energy consumption (EC), CO2 emissions (CE), and economic growth (GDP; gross domestic product) in 24 African countries using a panel autoregressive distributed lag (ARDL) approach. The following findings are established. First, there is a long-run relationship between EC, CE, and GDP. Second, a long-term effect from CE to GDP and EC is apparent, with reciprocal paths. Third, the error correction mechanisms are consistently stable. However, in cases of disequilibrium, only EC can be significantly adjusted to its long-run relationship. Fourth, there is a long-run causality running from GDP and CE to EC. Fifth, we find causality running from either CE or both CE and EC to GDP, and inverse causal paths are observable. Causality from EC to GDP is not strong, which supports the conservative hypothesis. Sixth, the causal direction from EC to GDP remains unobservable in the short term. By contrast, the opposite path is observable. There are also no short-run causalities from GDP, or EC, or EC, and GDP to EC. Policy implications are discussed.

  12. Temporal changes in serum creatine kinase concentration and degree of muscle rigidity in 24 patients with neuroleptic malignant syndrome

    Directory of Open Access Journals (Sweden)

    Nisijima K

    2013-06-01

    Full Text Available Koichi Nisijima, Katutoshi ShiodaDepartment of Psychiatry, Jichi Medical University, Tochigi, JapanAbstract: Neuroleptic malignant syndrome (NMS is a dangerous adverse response to antipsychotic drugs. It is characterized by the four major clinical symptoms of hyperthermia, severe muscle rigidity, autonomic dysfunction, and altered mental state. Serum creatine kinase (CK elevation occurs in over 90% of NMS cases. In the present study, the detailed temporal changes in serum CK and degree of muscle rigidity, and the relationship between CK concentration and degree of muscle rigidity over the time course from fever onset, were evaluated in 24 affected patients. The results showed that serum CK peaked on day 2 after onset of fever and returned to within normal limits at day 12. Mild muscle rigidity was observed before the onset of fever in 17 of 24 cases (71%. Muscle rigidity was gradually exacerbated and worsened until day 4 after onset of fever. These findings confirm physicians' empirical understanding of serum CK concentrations and muscle rigidity in NMS based on data accumulated from numerous patients with the syndrome, and they indicate that serum CK may contribute to the early detection of NMS.Keywords: neuroleptic malignant syndrome, creatine kinase, muscle rigidity

  13. Neutron occupancy of the 0d5/2 orbital and the N=16 shell closure in 24O

    Directory of Open Access Journals (Sweden)

    K. Tshoo

    2014-12-01

    Full Text Available One-neutron knockout from 24O leading to the first excited state in 23O has been measured for a proton target at a beam energy of 62 MeV/nucleon. The decay energy spectrum of the neutron unbound state of 23O was reconstructed from the measured four momenta of the 22O fragment and emitted neutron. A sharp peak was found at Edecay=50±3 keV, corresponding to an excited state in 23O at 2.78±0.11 MeV, as observed in previous measurements. The longitudinal momentum distribution for this state was consistent with d-wave neutron knockout, providing support for a Jπ assignment of 5/2+. The associated spectroscopic factor was deduced to be C2S(0d5/2=4.1±0.4 by comparing the measured cross section (σ−1nexp=61±6 mb with a distorted wave impulse approximation calculation. Such a large occupancy for the neutron 0d5/2 orbital is in line with the N=16 shell closure in 24O.

  14. NGS panel analysis in 24 ectopia lentis patients; a clinically relevant test with a high diagnostic yield.

    Science.gov (United States)

    Overwater, E; Floor, K; van Beek, D; de Boer, K; van Dijk, T; Hilhorst-Hofstee, Y; Hoogeboom, A J M; van Kaam, K J; van de Kamp, J M; Kempers, M; Krapels, I P C; Kroes, H Y; Loeys, B; Salemink, S; Stumpel, C T R M; Verhoeven, V J M; Wijnands-van den Berg, E; Cobben, J M; van Tintelen, J P; Weiss, M M; Houweling, A C; Maugeri, A

    2017-09-01

    Several genetic causes of ectopia lentis (EL), with or without systemic features, are known. The differentiation between syndromic and isolated EL is crucial for further treatment, surveillance and counseling of patients and their relatives. Next generation sequencing (NGS) is a powerful tool enabling the simultaneous, highly-sensitive analysis of multiple target genes. The aim of this study was to evaluate the diagnostic yield of our NGS panel in EL patients. Furthermore, we provide an overview of currently described mutations in ADAMTSL4, the main gene involved in isolated EL. A NGS gene panel was analysed in 24 patients with EL. A genetic diagnosis was confirmed in 16 patients (67%). Of these, four (25%) had a heterozygous FBN1 mutation, 12 (75%) were homozygous or compound heterozygous for ADAMTSL4 mutations. The known European ADAMTSL4 founder mutation c.767_786del was most frequently detected. The diagnostic yield of our NGS panel was high. Causative mutations were exclusively identified in ADAMTSL4 and FBN1. With this approach the risk of misdiagnosis or delayed diagnosis can be reduced. The value and clinical implications of establishing a genetic diagnosis in patients with EL is corroborated by the description of two patients with an unexpected underlying genetic condition. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  15. [Concordance of glomerular filtration rate with creatinine clearance in 24-hour urine and Schwartz and Schwartz updated].

    Science.gov (United States)

    Salazar-Gutiérrez, María Luisa; Ochoa-Ponce, Cristina; Lona-Reyes, Juan Carlos; Gutiérrez-Íñiguez, Sara Ivonne

    Reference methods for the quantification of the glomerular filtration rate (GFR) are difficult to use in clinical practice; formulas for evaluating GFR based on serum creatinine (SCr) and/or creatinine clearance are used. The aim of this study was to quantify the correlation and concordance of GFR with creatinine clearance in 24-hour urine (GFR24) and Schwartz and Schwartz updated formulas. Cross-sectional study involving healthy pediatric patients and with chronic kidney disease (CKD) from 5 to 16.9 years. Linear correlation between GFR 24 and two formulas was evaluated with the Pearson correlation coefficient (r) and intraclass correlation coefficient (ICC). We studied 134 patients, of which 59.7% were male. Mean age was 10.8 years. The average GFR24 was 140.34ml/min/1.73m 2 ; 34.3% (n=46) had GFR Schwartz (r= 0.63) and Schwartz updated (r= 0.65) formulas was observed. There was good concordance between the GFR24 and Schwartz (ICC= 0.77) and updated Schwartz (ICC= 0.77) formulas. Schwartz classical formula in patients with GFR24 ≥ 90ml/min/1.73m 2 estimated higher values, while Schwartz updated underestimated values. There is moderate correlation and good concordance between the GFR24 and Schwartz and Schwartz updated formulas. The concordance was better in patients with obesity and lower in women, patients with hyperfiltration and normal weight. Copyright © 2016 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

  16. STRENGTH AND SHORT-TERM DURABILITY OF 6M, 8M, 10M GEO-POLYMERS CONCRETE

    OpenAIRE

    Gladwin Vimal Raj.P*, Tamilvanan.K, Jose Ravindra Raj.B

    2017-01-01

    India is a developing country concentrated to develop the infrastructure and implement new construction techniques. Concrete is a main source of developing structure. It makes a great demand second only after water. So need an alternative to prevent this demand. Concrete is the mixture of cement, river sand and coarse aggregate. Cement manufacture produce carbon-di oxide and make ozone layer depletion cause global warming. Scarcity of river sand makes a demand in construction. So need an alte...

  17. Rapid GNSS and Data Communication System Deployments In Chile and Argentina Following the M8.8 Maule Earthquake

    Science.gov (United States)

    Blume, F.; Meertens, C. M.; Brooks, B. A.; Bevis, M. G.; Smalley, R.; Parra, H.; Baez, J.

    2010-12-01

    Because the signal is so big, great earthquakes allow us to make quantum leaps in our understanding of Earth deformation process and material properties. The Maule earthquake, with its occurrence near a large subaerial landmass and the large numbers of instruments available to study it, will surely become one of the most important geophysical events in modern memory. Much of the important signal, however, decays and changes rapidly in the short-term following the event and so a rapid response is necessary. Actually delivering the data from the CGPS response stations, however, represents an intellectual challenge in terms of properly matching the engineering realities with the scientific desiderata. We expect multiple major science advances to come from these data: (1) Understanding earthquake and tsunami-genesis via use of the coseismic displacement field to create the most well-constrained fault slip and tsunami-genesis models. (2) The role of stress loading on both the principal thrust plane and subsidiary planes. (3) The relationship between fault afterslip to the main event as well as to the distribution of aftershocks (4) Study of large aftershocks jointly using conventional seismology and high-rate GPS coseismic displacement seismogram. (5) Rheological behavior of the fault interface. (6) The mechanical response of the bulk earth to large stress perturbations. Within 10 days of the earthquake 20 complete GPS systems were delivered by UNAVCO personnel to IGM and OSU staff in Santiago, and 5 were shipped via diplomatic pouch to Argentina. Consisting of of 10 Trimble NetRS and 15 Topcon GB-1000 receivers, the units were deployed througout the affected area during the following three weeks, using welded-in-place steel tripod monuments driven into soil or drilled into bedrock, or steel masts. Additional GPS hardware was procured from cooperating institutions and donated by GPS manufacturers, and a total of 43 post-earthquake GPS stations are continuously operating in the epicentral area. UNAVCO has developed and deplyed standalone data communications systems at 25 of the stations: (1) the satellite-based Inmarsat Broad Global Area Service (BGAN), (2) ground based cellular internet services provided by a number of telecom companies in Chile and Argentina. Cellular service is economical but prone to disruptions following earthquakes and coverage is limited. BGAN is expensive but robust and globally available. This communication plan has allowed for daily downloads of 15 sec. data and of 1 sec. data recorded during aftershocks of M6.5 and greater. RINEX files from these stations are publicly available at the UNAVCO Facility Archive immediately after data are downloaded, a first for Event Response GPS data. This effort will serve as the type example in the geodetic community for rapid CGPS data communications following a destructive earthquake. The communications system hardware purchased during this response will become part of the UNAVCO pool after one year and will be available for future PI projects and event responses.

  18. Onderstam M.8 als alternatief voor M.9 : vraag naar minder gevoelige onderstam voor bacterievuur neemt toe

    NARCIS (Netherlands)

    Steeg, van der P.A.H.; Maas, F.M.

    2012-01-01

    Bacterievuur is in toenemende mate een bedreiging voor de appelteelt in Europa. Nederlandse boomkwekers produceren veel onderstammen en bomen bestemd voor export naar vrijwel alle landen in Europa. Door het toenemende handelsverkeer van plantmateriaal in de EU neemt de kans op verspreiding van en

  19. Comparison of sodium, potassium, calcium, magnesium, zinc, copper and iron concentrations of elements in 24-h urine and spot urine in hypertensive patients with healthy renal function.

    Science.gov (United States)

    Zhang, Tianjing; Chang, Xiaoyu; Liu, Wanlu; Li, Xiaoxia; Wang, Faxuan; Huang, Liping; Liao, Sha; Liu, Xiuying; Zhang, Yuhong; Zhao, Yi

    2017-12-01

    Sodium, potassium, calcium, magnesium, zinc, copper and iron are associated with the sequela of hypertension. The most reliable method for testing those elements is by collecting 24-h urine samples. However, this is cumbersome and collection of spot urine is more convenient in some circumstance. The aim of this study was to compare the concentrations of different elements in 24-h urine and spot urine. Data was collected from a sub-study of China Salt Substitute and Stroke Study. 240 participants were recruited randomly from 12 villages in two counties in Ningxia, China. Both spot and 24-h urine specimens were collected from each patient. Routine urine test was conducted, and concentration of elements was measured using microwave digestion and Inductively Coupled Plasma-Optical Emission Spectrometry. Partial correlation analysis and Spearman correlation analysis were used to investigate the concentration of different elements and the relationship between 24- h urine and spot urine. A partial correlation in sodium, potassium, calcium, magnesium and iron was found between paired 24-h urine and spot urine samples except copper and zinc: 0.430, 0.426, 0.550, 0.221 and 0.191 respectively. Spot urine can replace 24-h urine for estimating some of the elements in hypertensive patients with normal renal function. Copyright © 2017 Elsevier GmbH. All rights reserved.

  20. Acute respiratory infection, diarrhoea and fever in young children at-risk of intellectual disability in 24 low- and middle-income countries.

    Science.gov (United States)

    Emerson, Eric; Savage, Amber

    2017-01-01

    This study aims to (1) estimate the prevalence of acute respiratory infection (ARI) symptoms, diarrhoea and fever in the previous two weeks among 3-4 year old children who are/are not at-risk of intellectual disability in 24 low- and middle-income countries and (2) to investigate possible inequities in access to treatment among affected children. Cross-sectional survey. Secondary analysis of Rounds 4 and 5 UNICEF Multiple Indicator Cluster Surveys (MICS) from 24 low- and middle-income countries (n = 99,934 children). Pooled estimates indicated that young children at-risk of intellectual disability in low-income countries were significantly more likely than their peers to have reported symptoms of ARI and diarrhoea in the previous 2 weeks, and significantly less likely to have received appropriate treatment. Pooled estimates indicated that in middle-income countries children at-risk of intellectual disability were significantly more likely than their peers to have reported symptoms of ARI, diarrhoea and fever during the previous 2 weeks. Symptomatic children at-risk of intellectual disability were significantly less likely than their peers to have received antibiotics/antimotility medication for diarrhoea or antibiotics for ARI symptoms, but significantly more likely to be prescribed anti-malarials for fever. These results indicate the existence of significant inequalities and possible inequities in the exposure to and the treatment of three major infectious diseases among children who are/are not considered at-risk of intellectual disabilities in low- and middle-income countries. Copyright © 2016 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  1. Landscape variation in tree regeneration and snag fall drive fuel loads in 24-year old post-fire lodgepole pine forests.

    Science.gov (United States)

    Nelson, Kellen N; Turner, Monica G; Romme, William H; Tinker, Daniel B

    2016-12-01

    Escalating wildfire in subalpine forests with stand-replacing fire regimes is increasing the extent of early-seral forests throughout the western USA. Post-fire succession generates the fuel for future fires, but little is known about fuel loads and their variability in young post-fire stands. We sampled fuel profiles in 24-year-old post-fire lodgepole pine (Pinus contorta var. latifolia) stands (n = 82) that regenerated from the 1988 Yellowstone Fires to answer three questions. (1) How do canopy and surface fuel loads vary within and among young lodgepole pine stands? (2) How do canopy and surface fuels vary with pre- and post-fire lodgepole pine stand structure and environmental conditions? (3) How have surface fuels changed between eight and 24 years post-fire? Fuel complexes varied tremendously across the landscape despite having regenerated from the same fires. Available canopy fuel loads and canopy bulk density averaged 8.5 Mg/ha (range 0.0-46.6) and 0.24 kg/m 3 (range: 0.0-2.3), respectively, meeting or exceeding levels in mature lodgepole pine forests. Total surface-fuel loads averaged 123 Mg/ha (range: 43-207), and 88% was in the 1,000-h fuel class. Litter, 1-h, and 10-h surface fuel loads were lower than reported for mature lodgepole pine forests, and 1,000-h fuel loads were similar or greater. Among-plot variation was greater in canopy fuels than surface fuels, and within-plot variation was greater than among-plot variation for nearly all fuels. Post-fire lodgepole pine density was the strongest positive predictor of canopy and fine surface fuel loads. Pre-fire successional stage was the best predictor of 100-h and 1,000-h fuel loads in the post-fire stands and strongly influenced the size and proportion of sound logs (greater when late successional stands had burned) and rotten logs (greater when early successional stands had burned). Our data suggest that 76% of the young post-fire lodgepole pine forests have 1,000-h fuel loads that exceed levels

  2. [Perceptions and attitudes of public health service dentists in the face of family violence in 24 municipalities in the state of São Paulo, Brazil, 2013-2014].

    Science.gov (United States)

    Garbin, Cléa Adas Saliba; Rovida, Tânia Adas Saliba; Costa, Adriana Alves; Garbin, Artênio José Isper

    2016-01-01

    to describe the perceptions and attitudes of dentists working in Primary Healthcare Units in the face of family violence in 24 municipalities in the interior of São Paulo state, Brazil. this is a descriptive study conducted between July 2013 and July 2014; the study population was comprised of 294 professionals; data were collected through a questionnaire containing objective and subjective questions. 111 dentists took part (37.8%), 67.5% of whom were unaware of existing legislation on cases of violence; 70.0% did not know how to report the occurrence of cases; 55.0% reported not having any responsibility for notification; 85.0% were unaware of the notification form; and 60.0% said they should intervene in cases of family violence. the perceptions and attitudes of dentists have shortcomings in relation to notification of family violence and this hinders early diagnosis of the victims of such violence.

  3. Testing earthquake links in Mexico from 1978 up to the 2017 M=8.1 Chiapas and M=7.1 Puebla shocks

    Science.gov (United States)

    Segou, Margarita; Parsons, Thomas E.

    2018-01-01

    The M = 8.1 Chiapas and the M = 7.1 Puebla earthquakes occurred in the bending part of the subducting Cocos plate 11 days and ~600 km apart, a range that puts them well outside the typical aftershock zone. We find this to be a relatively common occurrence in Mexico, with 14% of M > 7.0 earthquakes since 1900 striking more than 300 km apart and within a 2 week interval, not different from a randomized catalog. We calculate the triggering potential caused by crustal stress redistribution from large subduction earthquakes over the last 40 years. There is no evidence that static stress transfer or dynamic triggering from the 8 September Chiapas earthquake promoted the 19 September earthquake. Both recent earthquakes were promoted by past thrust events instead, including delayed afterslip from the 2012 M = 7.5 Oaxaca earthquake. A repeated pattern of shallow thrust events promoting deep intraslab earthquakes is observed over the past 40 years.

  4. Probing the magnetosphere of the M8.5 dwarf TVLM 513-46546 by modelling its auroral radio emission. Hint of star exoplanet interaction?

    Science.gov (United States)

    Leto, P.; Trigilio, C.; Buemi, C. S.; Umana, G.; Ingallinera, A.; Cerrigone, L.

    2017-08-01

    In this paper, we simulate the cyclic circularly polarized pulses of the ultracool dwarf TVLM 513-46546, observed with the Very Large Array at 4.88 and 8.44 GHz on 2006 May, by using a three-dimensional model of the auroral radio emission from the stellar magnetosphere. During this epoch, the radio light curves are characterized by two pulses left-hand polarized at 4.88 GHz, and one doubly peaked (of opposite polarizations) pulse at 8.44 GHz. To take into account the possible deviation from the dipolar symmetry of the stellar magnetic-field topology, the model described in this paper is also able to simulate the auroral radio emission from a magnetosphere shaped like an offset dipole. To reproduce the timing and pattern of the observed pulses, we explored the space of parameters controlling the auroral beaming pattern and the geometry of the magnetosphere. Through the analysis of the TVLM 513-46546 auroral radio emission, we derive some indications on the magnetospheric field topology that is able to simultaneously reproduce the timing and patterns of the auroral pulses measured at 4.88 and 8.44 GHz. Each set of model solutions simulates two auroral pulses (singly or doubly peaked) per period. To explain the presence of only one 8.44 GHz pulse per period, we analyse the case of auroral radio emission limited only to a magnetospheric sector activated by an external body, like the case of the interaction of Jupiter with its moons.

  5. Analysis of the Source and Ground Motions from the 2017 M8.2 Tehuantepec and M7.1 Puebla Earthquakes

    Science.gov (United States)

    Melgar, D.; Sahakian, V. J.; Perez-Campos, X.; Quintanar, L.; Ramirez-Guzman, L.; Spica, Z.; Espindola, V. H.; Ruiz-Angulo, A.; Cabral-Cano, E.; Baltay, A.; Geng, J.

    2017-12-01

    The September 2017 Tehuantepec and Puebla earthquakes were intra-slab earthquakes that together caused significant damage in broad regions of Mexico, including the states of Oaxaca, Chiapas, Morelos, Puebla, Mexico, and Mexico City. Ground motions in Mexico City have approximately the same angle of incidence from both earthquakes and potentially sample similar paths close to the city. We examine site effects and source terms by analysis of residuals between Ground-Motion Prediction Equations (GMPEs) and observed ground motions for both of these events at stations from the Servicio Sismólogico Nacional, Instituto de Ingeniería, and the Instituto de Geofísica Red del Valle de Mexico networks. GMPEs are a basis for seismic design, but also provide median ground motion values to act as a basis for comparison of individual earthquakes and site responses. First, we invert for finite-fault slip inversions for Tehuantepec with high-rate GPS, static GPS, tide gauge and DART buoy data, and for Puebla with high-rate GPS and strong motion data. Using the distance from the stations with ground motion observations to the derived slip models, we use the GMPEs of Garcia et al. (2005), Zhao et al. (2006), and Abrahamson, Silva and Kamai (2014), to compute predicted values of peak ground acceleration and velocity (PGA and PGV) and response spectral accelerations (SA). Residuals between observed and predicted ground motion parameters are then computed for each recording, and are decomposed into event and site components using a mixed effects regression. We analyze these residuals as an adjustment away from median ground motions in the region to glean information about the earthquake source properties, as well as local site response in and outside of the Mexico City basin. The event and site terms are then compared with available values of stress drop for the two earthquakes, and Vs30 values for the sites, respectively. This analysis is useful in determining which GMPE is most appropriate in the central Mexico region, important for future ground motion studies and rapid response products such as ShakeMap.

  6. Study and realisation of a vertical chain-saw for working in shielded cell and controlled from Argonne M8 remote manipulators

    International Nuclear Information System (INIS)

    Roussel, E.; Aublin, R.

    1962-01-01

    The authors present a machine aimed at sawing nuclear fuel elements, irradiated materials or experimental assemblies coming from the EL3 reactor, and requiring a transport by using specific hoods. They indicate the various assembly types to be machined, and then present the machine itself with its fixed part, its mobile part, its control, its materials (and their coating), the cutting oil circuit. They also describe the different machining possibilities, and then address decontamination issues (in-cell partial dismounting and pre-decontamination, final decontamination). Then, they outline the presence of some original devices on this machine. Drawings and plans are provided

  7. Cross section measurements of radiative KL2,3 RRS in 24Cr and L3M4,5 RRS in 59Pr for Mn Kα1,2 X-rays

    Science.gov (United States)

    Sharma, Veena; Upmanyu, Arun; Singh, Ranjit; Singh, Gurjot; Sharma, Hitesh; Kumar, Sanjeev; Mehta, D.

    2017-06-01

    The KL2,3 and L3M4,5 radiative resonant Raman scattering (RRS) cross sections have been measured for the quasimonochromatic Mn Kα1,2 X-rays (5.895 keV) in 24Cr (K-shell level width (ΓK) =1.08 eV) and 59 Pr (L3-subshell level width (ΓL3) =3.60 eV), respectively, using targets in metallic and various chemical forms. The incident Mn Kα1,2 X-ray energy is lower than the K-shell binding energy of 24Cr and L3-subshell binding energy of 59Pr by 94 ΓK (Cr) and 94 ΓL3 (Pr), respectively. The experimental measurements were performed with a low energy Ge detector (LEGe) and a radioactive 55Fe annular source in conjunction with 24Cr absorber. The measured cross section values for the 24Cr and 59 Pr elements in their various oxidation states are found to be same within experimental errors. The measurements were further extended to investigate alignment of the intermediate L3-subshell (J =3/2) virtual vacancy states in 59Pr through angular distribution measurements for RRS photon emission, which is found to be isotropic within experimental errors.

  8. Acute Low-Volume High-Intensity Interval Exercise and Continuous Moderate-Intensity Exercise Elicit a Similar Improvement in 24-h Glycemic Control in Overweight and Obese Adults.

    Science.gov (United States)

    Parker, Lewan; Shaw, Christopher S; Banting, Lauren; Levinger, Itamar; Hill, Karen M; McAinch, Andrew J; Stepto, Nigel K

    2016-01-01

    Background: Acute exercise reduces postprandial oxidative stress and glycemia; however, the effects of exercise intensity are unclear. We investigated the effect of acute low-volume high-intensity interval-exercise (LV-HIIE) and continuous moderate-intensity exercise (CMIE) on glycemic control and oxidative stress in overweight and obese, inactive adults. Methods: Twenty-seven adults were randomly allocated to perform a single session of LV-HIIE (9 females, 5 males; age: 30 ± 1 years; BMI: 29 ± 1 kg·m -2 ; mean ± SEM) or CMIE (8 females, 5 males; age: 30 ± 2.0; BMI: 30 ± 2.0) 1 h after consumption of a standard breakfast. Plasma redox status, glucose and insulin were measured. Continuous glucose monitoring (CGM) was conducted during the 24-h period before (rest day) and after exercise (exercise day). Results: Plasma thiobarbituric acid reactive substances (TBARS; 29 ±13%, p improvement in 24-h average glucose levels (-5 ± 2%, p improving 24-h glycemic control in overweight and obese adults.

  9. Children’s School-Breakfast Reports and School-Lunch Reports (in 24-hour Dietary Recalls): Conventional and Reporting-Error-Sensitive Measures Show Inconsistent Accuracy Results for Retention Interval and for Breakfast Location

    Science.gov (United States)

    Baxter, Suzanne Domel; Guinn, Caroline H.; Smith, Albert F.; Hitchcock, David B.; Royer, Julie A.; Puryear, Megan P.; Collins, Kathleen L.; Smith, Alyssa L.

    2017-01-01

    Validation-study data were analyzed to investigate retention interval (RI) and prompt effects on accuracy of fourth-grade children’s reports of school-breakfast and school-lunch (in 24-hour recalls), and accuracy of school-breakfast reports by breakfast location (classroom; cafeteria). Randomly-selected fourth-grade children at 10 schools in four districts were observed eating school-provided breakfast and lunch, and interviewed under one of eight conditions (two RIs [short (prior-24-hour recall obtained in afternoon); long (previous-day recall obtained in morning)] crossed with four prompts [forward (distant-to-recent), meal-name (breakfast, etc.), open (no instructions), reverse (recent-to-distant)]). Each condition had 60 children (half girls). Of 480 children, 355 and 409 reported meals satisfying criteria for reports of school-breakfast and school-lunch, respectively. For breakfast and lunch separately, a conventional measure—report rate—and reporting-error-sensitive measures—correspondence rate and inflation ratio—were calculated for energy per meal-reporting child. Correspondence rate and inflation ratio—but not report rate—showed better accuracy for school-breakfast and school-lunch reports with the short than long RI; this pattern was not found for some prompts for each sex. Correspondence rate and inflation ratio showed better school-breakfast report accuracy for the classroom than cafeteria location for each prompt, but report rate showed the opposite. For each RI, correspondence rate and inflation ratio showed better accuracy for lunch than breakfast, but report rate showed the opposite. When choosing RI and prompts for recalls, researchers and practitioners should select short RIs to maximize accuracy. Recommendations for prompt selections are less clear. As report rates distort validation-study accuracy conclusions, reporting-error-sensitive measures are recommended. PMID:26865356

  10. Children's school-breakfast reports and school-lunch reports (in 24-h dietary recalls): conventional and reporting-error-sensitive measures show inconsistent accuracy results for retention interval and breakfast location.

    Science.gov (United States)

    Baxter, Suzanne D; Guinn, Caroline H; Smith, Albert F; Hitchcock, David B; Royer, Julie A; Puryear, Megan P; Collins, Kathleen L; Smith, Alyssa L

    2016-04-14

    Validation-study data were analysed to investigate retention interval (RI) and prompt effects on the accuracy of fourth-grade children's reports of school-breakfast and school-lunch (in 24-h recalls), and the accuracy of school-breakfast reports by breakfast location (classroom; cafeteria). Randomly selected fourth-grade children at ten schools in four districts were observed eating school-provided breakfast and lunch, and were interviewed under one of eight conditions created by crossing two RIs ('short'--prior-24-hour recall obtained in the afternoon and 'long'--previous-day recall obtained in the morning) with four prompts ('forward'--distant to recent, 'meal name'--breakfast, etc., 'open'--no instructions, and 'reverse'--recent to distant). Each condition had sixty children (half were girls). Of 480 children, 355 and 409 reported meals satisfying criteria for reports of school-breakfast and school-lunch, respectively. For breakfast and lunch separately, a conventional measure--report rate--and reporting-error-sensitive measures--correspondence rate and inflation ratio--were calculated for energy per meal-reporting child. Correspondence rate and inflation ratio--but not report rate--showed better accuracy for school-breakfast and school-lunch reports with the short RI than with the long RI; this pattern was not found for some prompts for each sex. Correspondence rate and inflation ratio showed better school-breakfast report accuracy for the classroom than for cafeteria location for each prompt, but report rate showed the opposite. For each RI, correspondence rate and inflation ratio showed better accuracy for lunch than for breakfast, but report rate showed the opposite. When choosing RI and prompts for recalls, researchers and practitioners should select a short RI to maximise accuracy. Recommendations for prompt selections are less clear. As report rates distort validation-study accuracy conclusions, reporting-error-sensitive measures are recommended.

  11. [Lessons and impact of two audits on postpartum hemorrhages in 24 maternity hospitals of the network "Sécurité Naissance - Naître Ensemble" in "Pays-de-la-Loire" area].

    Science.gov (United States)

    Branger, B; Gillard, P; Monrigal, C; Thelu, S; Robidas, E; Viot, S; Descamps, P; Philippe, H-J; Sentilhes, L; Winer, N

    2011-11-01

    The aim of the study is to assess the compliance rate of treatment of postpartum hemorrhage (PPH) according to guidelines developed by the CNGOF within our network by a first audit, and evaluate the impact of this first audit by conducting a second audit. An initial audit of resources and management of postpartum hemorrhage (PPH) was conducted in 2006-2008 in 24 maternity hospitals of the Pays-de-la-Loire. The audit had identified six areas for improvement. A second audit was implemented in 2009-2010 to evaluate the actions of prevention and measure changes in the management of PPH. Two interns have distributed the 24 maternity homes and moved in each hospital to see 10 cases of vaginal delivery (VD) (section "Prevention"), and the last cases of PPH following a VD. The results are in compliance rate compared to the repository of the HAS in 2004. The first audit was conducted on 101 PPH in total. It has allowed us to propose corrective actions to the 24 maternity hospitals: leaf specific monitoring, reporting amounts of blood loss, transfusion on these clinical criteria without waiting for the blood cell counts, indicating more frequent and rapid sulprostone, set for maternity hospitals without surgical skill an agreement with a visceral surgery department, and avoid maternal transfers for PPH. For the second audit, the compliance rate of the preventive aspect was 73% (95: 71-75%) of 239 cases of BA with variations according to maternity from 48 to 93%. Compliance rates according to the criteria were: 99% obstetric consultations, 98% for anesthesia, 92% for hemoglobin, 77% for the group card available in the record, 89% agglutinins, 35% for the notification of the installation of bag, 36% for the notification of the amount of blood lost, 69% for the supervisor within two hours, and 64% for the directed delivery. For component "Support", the overall compliance rate was 81% (95: 79-83%) of 118 PPH AVB, and 85% in the 71 uterine atonies in 21 pregnancies (3 had no HPP

  12. Mandibular bone changes in 24 years and skeletal fracture prediction.

    Science.gov (United States)

    Jonasson, G; Sundh, V; Hakeberg, M; Hassani-Nejad, A; Lissner, L; Ahlqwist, M

    2013-03-01

    The objectives of the investigation were to describe changes in mandibular bone structure with aging and to compare the usefulness of cortical and trabecular bone for fracture prediction. From 1968 to 1993, 1,003 women were examined. With the help of panoramic radiographs, cortex thickness was measured and cortex was categorized as: normal, moderately, or severely eroded. The trabeculation was assessed as sparse, mixed, or dense. Visually, the mandibular compact and trabecular bone transformed gradually during the 24 years. The compact bone became more porous, the intertrabecular spaces increased, and the radiographic image of the trabeculae seemed less mineralized. Cortex thickness increased up to the age of 50 and decreased significantly thereafter. At all examinations, the sparse trabeculation group had more fractures (71-78 %) than the non-sparse group (27-31 %), whereas the severely eroded compact group showed more fractures than the less eroded groups only in 1992/1993, 24 years later. Sparse trabecular pattern was associated with future fractures both in perimenopausal and older women (relative risk (RR), 1.47-4.37) and cortical erosion in older women (RR, 1.35-1.55). RR for future fracture associated with a severely eroded cortex increased to 4.98 for cohort 1930 in 1992/1993. RR for future fracture associated with sparse trabeculation increased to 11.43 for cohort 1922 in 1992/1993. Dental radiographs contain enough information to identify women most at risk of future fracture. When observing sparse mandibular trabeculation, dentists can identify 40-69 % of women at risk for future fractures, depending on participant age at examination.

  13. Pulmonary MALT lymphoma: imaging findings in 24 cases

    Energy Technology Data Exchange (ETDEWEB)

    King, L.J. [Dept. of Radiology, Royal Hospital Haslar, Hampshire (United Kingdom); Padley, S.P.G. [Dept. of Radiology, Royal Brompton Hospital, London (United Kingdom); Wotherspoon, A.C. [Dept. of Histopathology, Royal Marsden Hospital, London (United Kingdom); Nicholson, A.G. [Dept. of Histopathology, Royal Brompton Hospital, London (United Kingdom)

    2000-12-01

    The aim of this study was to describe the imaging features of pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma. The chest radiographs (n = 18) and CT scans (n = 17) of 24 patients (18 men and 6 women) aged 27-78 years (mean = 56 years), with a known diagnosis of pulmonary MALT lymphoma, were retrospectively reviewed by two radiologists and the imaging findings are described. Six of the 24 patients had a history of an autoimmune disorder and 1 patient had acquired immune deficiency syndrome. Multiple pulmonary lesions were identified in 19 of 24 patients (79 %) and solitary lesions in 4 of 24 patients (17 %). Diffuse pulmonary infiltration was present in 1 patient. Lesions included masses or mass-like areas of consolidation (n = 21) and pulmonary nodules (n = 18). Associated findings were air bronchograms, airway dilatation, a positive angiogram sign and a halo of ground-glass shadowing at lesion margins. Peribronchovascular thickening was also observed, as were hilar or mediastinal lymph node enlargement and pleural effusions or thickening. Although rare, the diagnosis of pulmonary MALT lymphoma should be considered in patients with the imaging features described, particularly when in association with an indolent clinical course or a history of autoimmune disease. (orig.)

  14. Auxin and cytokinin relationships in 24 microalgal strains

    Czech Academy of Sciences Publication Activity Database

    Stirk, W.A.; Ördög, V.; Novák, Ondřej; Rolčík, Jakub; Strnad, Miroslav; Balint, P.; van Staden, J.

    2013-01-01

    Roč. 49, č. 3 (2013), s. 459-467 ISSN 0022-3646 R&D Projects: GA ČR GA206/09/1284 Grant - others:GA MŠk(CZ) ED0007/01/01 Program:ED Institutional research plan: CEZ:AV0Z50380511 Keywords : auxins * cytokinin free bases * cytokinin ribotides Subject RIV: ED - Physiology Impact factor: 2.529, year: 2013

  15. Multi-sensory stimulation in 24-hour dementia care

    NARCIS (Netherlands)

    Weert, J.C.M. van

    2004-01-01

    This thesis starts with a review of relevant literature with regard to the effects of psychosocial interventions, including snoezelen, on apathetic, depressed and aggressive behaviour of demented persons. Then, a study with a quasi-experimental pre-test and post-test design is described, comparing

  16. Microsatellite based investigation of genetic diversity in 24 synthetic ...

    African Journals Online (AJOL)

    Muhammad Shakeel

    2012-09-06

    Sep 6, 2012 ... molecular diagnostics have been evolved to the level that alien introgression detection no longer remains too complex a process. For speeding up alien introgression and production/maintenance of genetic stock programs, the use of polyhaploidy, through sexual hybridization of bread wheat, has emerged ...

  17. Reducing the variability of antibiotic production in Streptomyces by cultivation in 24-square deepwell plates

    DEFF Research Database (Denmark)

    Siebenberg, S.; Bapat, Prashant Madhusudhan; Eliasson Lantz, Anna

    2010-01-01

    of time. Originally, novobiocin titers in the deepwell plate (5-12 mg l(-1)) were lower than in Erlenmeyer flasks (24 mg Optimization of the inoculation procedure as well as addition of a siloxylated ethylene oxide/propylene oxide copolymer, acting as oxygen carrier, to the production medium increased...

  18. Feline infectious peritonitis with neurologic involvement: clinical and pathological findings in 24 cats

    International Nuclear Information System (INIS)

    Kline, K.L.; Joseph, R.J.; Averill, D.R. Jr.

    1994-01-01

    The medical records of 24 cats with histopathologically diagnosed feline infectious peritonitis involving the nervous system were reviewed. Seventeen cats had historical, clinical, and pathological findings of systemic disease. Twelve cats had focal signs of central nervous system dysfunction. Twelve cats had multifocal signs including seizures, nystagmus, head tilt, vestibular or cerebellar ataxia, paresis, and proprioceptive loss with a preponderance of caudal fossa signs. Computed tomography of the brain revealed hydrocephalus in two cats. Examination of cerebrospinal fluid revealed pyogranulomatous pleocytosis in fivecats; the tap was nonproductive in five cats. Findings on histopathological examination of appropriate tissues included nephritis, hepatitis, and pleuritis. Neuropathological findings included ependymitis, choroid plexitis, meningitis, encephalitis, and myelitis. Hydrocephalus was seen in 18 cats on necropsy

  19. Reproductive hormones and metabolic syndrome in 24 testicular cancer survivors and their biological brothers

    DEFF Research Database (Denmark)

    Bandak, M.; Jorgensen, N.; Juul, A.

    2017-01-01

    was to clarify if testicular cancer survivors have impaired gonadal function and increased risk of metabolic syndrome when compared to their biological brothers. A cross-sectional study of testicular cancer survivors (ClinicalTrials.gov number, NCT02240966) was conducted between 2014 and 2016. Of 158 testicular...... cancer survivors included, 24 had a biological brother who accepted to participate in the study. Serum levels of reproductive hormones and prevalence of metabolic syndrome according to International Diabetes Federation Criteria and National Cholesterol Education Program (Adult Treatment Panel III...

  20. Fermentation in 24-well plates is an efficient screening platform for filamentous fungi

    DEFF Research Database (Denmark)

    Linde, Tore; Hansen, Bjørn; Lübeck, Mette

    Conventional citric acid batch-fermentation by filamentous fungi is often linked with large variations in production levels. The most used citric acid batch-fermentation method described in literature is based on Erlenmeyer flasks with cotton-stoppers in a heated shaker. Our preliminary studies...... using Erlenmeyer flasks in sextuplicates showed a relative standard sample deviation of 54 % citric acid produced with the filamentous fungi Aspergillus carbonarius, thereby confirming these large variations. The objective of this study was to propose a different and more reliable screening method...... for citric acid production from filamentous fungi, using A. carbonarius as test organism in a 24 well plate system. The two systems where run simultaneously with only the mechanical parameters as difference between them. All experiments were performed in sextuplicates to be able to give a higher statistical...

  1. Laypersons may learn basic life support in 24min using a personal resuscitation manikin

    DEFF Research Database (Denmark)

    Isbye, Dan Lou; Rasmussen, Lars Simon; Lippert, Freddy Knudsen

    2006-01-01

    -55 years) without previous BLS-training were allocated into two groups: one group received 24 min of instruction using a DVD-based instruction tool on a big screen combined with a BLS self-training device, Laerdal MiniAnne manikin (MAM), before taking home the instruction material for subsequent self...... the total score. Assessment of breathing was performed significantly more often in the 6 HR-group (91% versus 72%, P=0.03). In the MAM-group, average inflation volume and chest compression depth were significantly higher (844 mL versus 524 mL, P=0.006, and 45 mm versus 39 mm, P=0.005). CONCLUSIONS: When...

  2. Fatigue Strength and Related Characteristics of Joints in 24s-t Alclad Sheet

    Science.gov (United States)

    Russell, H W; Jackson, L R; Grover, H J; Beaver, W W

    1944-01-01

    Report includes tension fatigue test results on the following types of samples of 0.040-inch alclad 24s-t: (1) monoblock sheet samples as received and after a post-aging heat treatment, (2) "sheet efficiency" samples (two equally stressed sheets joined by a single transverse row of spot welds) both as received and after post-aging, (3) spot-welded lap-joint samples as received and after post-aging, and (4) roll-welded lap-joint samples. (author)

  3. Entrance channel dependence of back angle yields: orbiting in 24Mg+16O reaction

    International Nuclear Information System (INIS)

    Ray, A.; Gil, S.; Khandaker, M.; Leach, D.D.; Lock, D.K.; Vandenbosch, R.

    1982-01-01

    The back-angle yields of the oxygen and carbon particles from the 24 Mg+ 16 O reaction have been measured at E/sub Lab/( 24 Mg) = 79.5 MeV by using reverse kinematics. Comparison with data for the 28 Si+ 12 C reaction forming the same compound nucleus at the same excitation energy and with very similar spin distribution, demonstrates a strong entrance channel effect which is favoring the break-up into the entrance channel with large excitation energy. This result qualitatively supports the picture of the formation of a long-lived orbiting complex whose structure and decay are dependent on the entrance channel. The compound nucleus contribution has been inferred to be less than 15% of the measured oxygen cross-section. 9 references

  4. Prediction of wax buildup in 24 inch cold, deep sea oil loading line

    Energy Technology Data Exchange (ETDEWEB)

    Asperger, R.G.; Sattler, R.E.; Tolonen, W.J.; Pitchford, A.C.

    1981-10-01

    When designing pipelines for cold environments, it is important to know how to predict potential problems due to wax deposition on the pipeline's inner surface. The goal of this work was to determine the rate of wax buildup and the maximum, equlibrium wax thickness for a North Sea field loading line. The experimental techniques and results used to evaluate the waxing potential of the crude oil (B) are described. Also, the theoretic model which was used for predicting the maximum wax deposit thickness in the crude oil (B) loading pipeline at controlled temperatures of 40 F (4.4 C) and 100 F (38 C), is illustrated. Included is a recommendation of a procedure for using hot oil at the end of a tanker loading period in order to dewax the crude oil (B) line. This technique would give maximum heating of the pipeline and should be followed by shutting the hot oil into the pipeline at the end of the loading cycle which will provide a hot oil soaking to help soften existing wax. 14 references.

  5. Therapeutic effect of terlipressin combined with albumin in 24 patients with hepatorenal syndrome

    Directory of Open Access Journals (Sweden)

    CHEN Si

    2014-08-01

    Full Text Available ObjectiveTo observe the therapeutic effect of terlipressin combined with albumin in management of patients with hepatorenal syndrome. MethodsA retrospective study enrolling 46 patients with hepatorenal syndrome from May 2011 to August 2013 was conducted, in which 22 patients were allocated to control group, and 24 patients to treatment group. In addition to conventional treatment, albumin was used in control group, and the patients in treatment group were treated with terlipressin plus albumin. Clinical symptoms, urine volume, serum creatinine, urea nitrogen, ascites, and prognosis were observed in the study. The Student′s t test was used for comparison between the two groups, and the chi-square test was used for comparison of rates. ResultsThe treatment group showed significant improvements in clinical symptoms, while the control group did not. In treatment group, urine volume (ml/24 h increased from (758.5±284.9 to (2277.1±704.8 (P<0.01; serum creatinine level (μmol/L dropped from (234.2±87.2 to (126.8±62.2 (P<0.01; urea nitrogen level (mmol/L dropped from (18.1±6.4 to (10.3±4.5 (P<0.01; body weight (kg dropped from (68.1±3.9 to (646±3.9 (P<0.01; abdominal circumference (cm dropped from (95.0±5.1 to (90.8±4.9 (P<0.01. However, the control group showed no significant changes in urine volume, serum creatinine, urea nitrogen, body weight, and abdominal circumference after treatment (P>0.05. There were significant differences in these indices between the two groups after treatment (P<0.05. Significant differences in remission rate and survival rate were observed between the control group and treatment group (P<0.05. ConclusionA combination of terlipressin and albumin has favorable therapeutic effect on hepatorenal syndrome and improves the prognosis of patients with hepatorenal syndrome.

  6. Disruption of transitional stages in 24-h blood pressure in renal transplant recipients

    Directory of Open Access Journals (Sweden)

    Marcelo E Katz

    2012-03-01

    Full Text Available Patients with kidney replacement exhibit disrupted circadian rhythms. Most studies measuring blood pressure use the dipper/non-dipper classification, which does not consider analysis of transitional stages between low and high blood pressure, confidence intervals nor shifts in the time of peak, while assuming subjective onsets of night and day phases. In order to better understand the nature of daily variation of blood pressure in these patients, we analyzed 24h recordings from 41 renal transplant recipients using the non-symmetrical double-logistic fitting assessment which does not assume abruptness nor symmetry in ascending and descending stages of the blood pressure profile, and a cosine best-fitting regression method (Cosinor. Compared with matched controls, double-logistic fitting showed that the times for most of transitional stages (ascending systolic and descending systolic, diastolic and mean arterial pressure had a wider distribution along the 24 h. The proportion of individuals without daily blood pressure rhythm in the transplanted group was larger only for systolic arterial pressure, and the amplitude showed no significant difference. Furthermore, the transplant recipient group had a less pronounced slope in descending systolic and ascending mean blood pressure. Cosinor analysis confirmed the phase related changes, showing a wider distribution of times of peak (acrophases. We conclude that daily disruptions in renal transplant recipients can be explained not only by absence in diurnal variation, but also in changes in waveform-related parameters of the rhythm, and that distortions in the phase of the rhythm are the most consistent finding for the patients.

  7. Time bound changes (in 24 h) in human sperm motility and level of ...

    African Journals Online (AJOL)

    A detailed sperm motility study for 24 h after collection was done. The level of calcium and magnesium in seminal plasma during this period was also seen to understand the role of these electrolytes on sperm motility. Good care was taken in selection of subjects (young and healthy), collection and pre-physical analysis of ...

  8. Widespread occurrence of neuro-active pharmaceuticals and metabolites in 24 Minnesota rivers and wastewaters

    Science.gov (United States)

    Writer, Jeffrey; Ferrer, Imma; Barber, Larry B.; Thurman, E. Michael

    2013-01-01

    Concentrations of 17 neuro-active pharmaceuticals and their major metabolites (bupropion, hydroxy-bupropion, erythro-hydrobupropion, threo-hydrobupropion, carbamazepine, 10,11,-dihydro-10,11,-dihydroxycarbamazepine, 10-hydroxy-carbamazepine, citalopram, N-desmethyl-citalopram, fluoxetine, norfluoxetine, gabapentin, lamotrigine, 2-N-glucuronide-lamotrigine, oxcarbazepine, venlafaxine and O-desmethyl-venlafaxine), were measured in treated wastewater and receiving surface waters from 24 locations across Minnesota, USA. The analysis of upstream and downstream sampling sites indicated that the wastewater treatment plants were the major source of the neuro-active pharmaceuticals and associated metabolites in surface waters of Minnesota. Concentrations of parent compound and the associated metabolite varied substantially between treatment plants (concentrations ± standard deviation of the parent compound relative to its major metabolite) as illustrated by the following examples; bupropion and hydrobupropion 700 ± 1000 ng L−1, 2100 ± 1700 ng L−1, carbamazepine and 10-hydroxy-carbamazepine 480 ± 380 ng L−1, 360 ± 400 ng L−1, venlafaxine and O-desmethyl-venlafaxine 1400 ± 1300 ng L−1, 1800 ± 2300 ng L−1. Metabolites of the neuro-active compounds were commonly found at higher or comparable concentrations to the parent compounds in wastewater effluent and the receiving surface water. Neuro-active pharmaceuticals and associated metabolites were detected only sporadically in samples upstream from the effluent outfall. Metabolite to parent ratios were used to evaluate transformation, and we determined that ratios in wastewater were much lower than those reported in urine, indicating that the metabolites are relatively more labile than the parent compounds in the treatment plants and in receiving waters. The widespread occurrence of neuro-active pharmaceuticals and metabolites in Minnesota effluents and surface waters indicate that this is likely a global environmental issue, and further understanding of the environmental fate and impacts of these compounds is warranted.

  9. Involvement of dehydrins in 24-epibrassinolide-induced protection of wheat plants against drought stress.

    Science.gov (United States)

    Shakirova, Farida; Allagulova, Chulpan; Maslennikova, Dilara; Fedorova, Kristina; Yuldashev, Ruslan; Lubyanova, Alsu; Bezrukova, Marina; Avalbaev, Azamat

    2016-11-01

    In this study, we performed a comparative analysis of the physiological and biochemical parameters of wheat cultivars with contrasting drought resistance, drought-resistant Omskaya 35 (O-35) and less drought-resistant Salavat Yulaev (SYu), during 7-day germination under drought stress simulated by 5% mannitol. In addition, we evaluated the effectiveness of pre-sowing seed treatment with 0.4 μM 24-epibrassinolide (EBR) used to increase the resistance of plants of both cultivars to drought stress. It was revealed that mannitol has caused significant changes in the hormonal balance of the plants of both cultivars, associated with abscisic acid (ABA) accumulation and decrease in the contents of indoleacetic acid (IAA) and cytokinins (CKs). It should be noted that more dramatic changes in the content of phytohormones were characteristic for seedlings of SYu cultivar, which was reflected in a stronger growth inhibition of these plants. Pretreatment with EBR mitigated the negative effect of drought on the hormonal status and growth of seedlings during their germination. Furthermore, we found that drought caused accumulation of dehydrin (DHN) proteins, especially of low molecular weight DHNs, whose abundance was 2.5 times greater in O-35 cultivar than in SYu plants. EBR-pretreated plants of both cultivars were characterized by the additional accumulation of DHNs, indicating their involvement in the development of the EBR-induced wheat drought resistance. The use of fluridone allowed us to demonstrate ABA-dependent and ABA-independent pathways of regulation of low molecular mass dehydrins accumulation by EBR in wheat plants of both cultivars under drought conditions. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  10. Behaviour and development in 24-month-old moderately preterm toddlers

    NARCIS (Netherlands)

    de Jong, Marjanneke; Verhoeven, Marjolein; Lasham, Carole A.; Meijssen, Clemens B.; van Baar, Anneloes L.

    2015-01-01

    OBJECTIVE: Moderately preterm children (gestational age 32-36+6 weeks) are at risk of cognitive and behaviour problems at school age. The aim of this study was to investigate if these problems are already present at the age of 2 years. STUDY DESIGN: Developmental outcome was assessed at 24-months

  11. Search for 12 C+ 12 C clustering in 24 Mg ground state

    Indian Academy of Sciences (India)

    In the backdrop of many models, the heavy cluster structure of the ground state of 24 Mg has been probed experimentally for the first time using the heavy cluster knockout reaction 24 Mg( 12 C, 212 C) 12 C in thequasifree scattering kinematic domain. In the ( 12 C, 212 C) reaction, the direct 12 C-knockout cross-section was ...

  12. Renewable energy, carbon emissions, and economic growth in 24 Asian countries: evidence from panel cointegration analysis.

    Science.gov (United States)

    Lu, Wen-Cheng

    2017-11-01

    This article aims to investigate the relationship among renewable energy consumption, carbon dioxide (CO 2 ) emissions, and GDP using panel data for 24 Asian countries between 1990 and 2012. Panel cross-sectional dependence tests and unit root test, which considers cross-sectional dependence across countries, are used to ensure that the empirical results are correct. Using the panel cointegration model, the vector error correction model, and the Granger causality test, this paper finds that a long-run equilibrium exists among renewable energy consumption, carbon emission, and GDP. CO 2 emissions have a positive effect on renewable energy consumption in the Philippines, Pakistan, China, Iraq, Yemen, and Saudi Arabia. A 1% increase in GDP will increase renewable energy by 0.64%. Renewable energy is significantly determined by GDP in India, Sri Lanka, the Philippines, Thailand, Turkey, Malaysia, Jordan, United Arab Emirates, Saudi Arabia, and Mongolia. A unidirectional causality runs from GDP to CO 2 emissions, and two bidirectional causal relationships were found between CO 2 emissions and renewable energy consumption and between renewable energy consumption and GDP. The findings can assist governments in curbing pollution from air pollutants, execute energy conservation policy, and reduce unnecessary wastage of energy.

  13. Causal Learning from Probabilistic Events in 24-Month-Olds: An Action Measure

    Science.gov (United States)

    Waismeyer, Anna; Meltzoff, Andrew N.; Gopnik, Alison

    2015-01-01

    How do young children learn about causal structure in an uncertain and variable world? We tested whether they can use observed probabilistic information to solve causal learning problems. In two experiments, 24-month-olds observed an adult produce a probabilistic pattern of causal evidence. The toddlers then were given an opportunity to design…

  14. Growth retardation due to idiopathic growth hormone deficiencies: MR findings in 24 patients

    International Nuclear Information System (INIS)

    Ochi, M.; Morikawa, M.; Yoshimoto, M.; Kinoshita, E.; Hayashi, K.

    1992-01-01

    In this study we evaluated the pituitary-hypothalamic abnormalities of ''idiopathic growth hormone (GH) deficiency'' as demonstrated by MR imaging. Twenty-four patients were examined with a 1.5-T unit using spin echo T-1 weighted images. The patients were divided into two groups according to MR findings: those with ectopic posterior pituitary glands (12 patients), and those with normal posterior pituitary glands (12 patients). Ten patients in the former group and four in the latter group had small anterior pituitary glands. All patients in the former group but only four in the latter group had severe GH deficiencies. Multiple hormone deficiencies were found in eight patients in the former group, but in only two in the latter group. It is speculated that perinatal abnormalities can cause posterior pituitary ectopia and that there is a close correlation between breech delivery and the male disadvantage of posterior pituitary ectopia. Half of our patients with ''idiopathic GH deficiency'' had ectopic posterior pituitaries. GH deficiency with posterior pituitary ectopia should no longer be considered idiopathic because organic lesions can now be identified during life. (orig./GD)

  15. Epidemiological comparisons of problems and positive qualities reported by adolescents in 24 countries

    DEFF Research Database (Denmark)

    Rescorla, Leslie; Achenbach, Thomas M; Ivanova, Masha Y

    2007-01-01

    ) ranged from 3% to 9%, whereas those for gender and age ranged from less than 1% to 2%. Scores were significantly higher for girls than for boys on Internalizing Problems and significantly higher for boys than for girls on Externalizing Problems. Bicountry correlations for mean problem item scores......In this study, the authors compared ratings of behavioral and emotional problems and positive qualities on the Youth Self-Report (T. M. Achenbach & L. A. Rescorla, 2001) by adolescents in general population samples from 24 countries (N = 27,206). For problem scales, country effect sizes (ESs...... averaged .69. For Total Problems, 17 of 24 countries scored within one standard deviation of the overall mean of 35.3. In the 19 countries for which parent ratings were also available, the mean of 20.5 for parent ratings was far lower than the self-report mean of 34.0 in the same 19 countries (d = 2...

  16. Obtaining liver tridimensional scaffold through the decellularization of rabbit whole liver in 24 hours

    Science.gov (United States)

    Federico, Schliamser; Ayelen, Rinaldi; Romina, Comin; Alba Nelly, Borchert; Adrian, Nari Gustavo; Alicia, Salvatierra Nancy; Mariana Paula, Cid

    2016-04-01

    In the present work, we development a new protocol for liver decellularization in which the hole decellularization was reached over 24 h. Introduction: the availability of transplantable livers is not sufficient to fulfill the current demand for grafts, with the search for therapeutic alternatives having generated different lines of research, one of which is the use of decellularized three-dimensional biological matrices and subsequent cell seeding to obtain a functional organ. Objective: to produce a decellularization protocol from rabbit liver to generate a three-dimensional matrixin which the time period involved didn't pass 24 h. Methods: The decellularization is obtained through the use of water and SDS (0,1-0,3 %), after freezing at -80 degrees, is the best alternative of different physical and/or chemical mechanisms to break down organ cells and leave only the extracellular matriz. After 24 h of retrograde perfusion, a decellularized translucent matrix was generated. To evaluate if the decellularization protocol was successful, with the extracellular matrix being preserved, we carried out histological (light microscopy) and biochemical (DNA quantification) studies. Results: the decellularization process was verified by macroscopic observation of the organ using microscopic observation corroborated the macroscopic results, with the hematoxylin-eosin and Masson staining showing no cells or nuclear material. In addition, the DNA quantification was less than 10% in the decellularized liver compared to control. Finally,the time taken to develop the decellularization protocol was less than 24 hours.

  17. Obtaining liver tridimensional scaffold through the decellularization of rabbit whole liver in 24 hours

    International Nuclear Information System (INIS)

    Federico, Schliamser; Ayelen, Rinaldi; Romina, Comin; Alicia, Salvatierra Nancy; Paula, Cid Mariana; Nelly, Borchert Alba; Adrian, Nari Gustavo

    2016-01-01

    In the present work, we development a new protocol for liver decellularization in which the hole decellularization was reached over 24 h. Introduction: the availability of transplantable livers is not sufficient to fulfill the current demand for grafts, with the search for therapeutic alternatives having generated different lines of research, one of which is the use of decellularized three-dimensional biological matrices and subsequent cell seeding to obtain a functional organ. Objective: to produce a decellularization protocol from rabbit liver to generate a three-dimensional matrixin which the time period involved didn't pass 24 h. Methods: The decellularization is obtained through the use of water and SDS (0,1-0,3 %), after freezing at -80 degrees, is the best alternative of different physical and/or chemical mechanisms to break down organ cells and leave only the extracellular matriz. After 24 h of retrograde perfusion, a decellularized translucent matrix was generated. To evaluate if the decellularization protocol was successful, with the extracellular matrix being preserved, we carried out histological (light microscopy) and biochemical (DNA quantification) studies. Results: the decellularization process was verified by macroscopic observation of the organ using microscopic observation corroborated the macroscopic results, with the hematoxylin-eosin and Masson staining showing no cells or nuclear material. In addition, the DNA quantification was less than 10% in the decellularized liver compared to control. Finally,the time taken to develop the decellularization protocol was less than 24 hours. (paper)

  18. Categorizing with Gender: Does Implicit Grammatical Gender Affect Semantic Processing in 24-Month-Old Toddlers?

    Science.gov (United States)

    Bobb, Susan C.; Mani, Nivedita

    2013-01-01

    The current study investigated the interaction of implicit grammatical gender and semantic category knowledge during object identification. German-learning toddlers (24-month-olds) were presented with picture pairs and heard a noun (without a preceding article) labeling one of the pictures. Labels for target and distracter images either matched or…

  19. Neutron occupancy of 0d5/2 orbital in 24O

    Directory of Open Access Journals (Sweden)

    Tshoo K.

    2014-03-01

    Full Text Available The partial one-neutron removal cross section of 24O leading to the first excited state in 23O has been measured to be 65.7 ± 5.3 mb with a proton target in inverse kinematics at the beam energy of 62 MeV/nucleon. The decay energy spectrum of the neutron unbound state of 23O was reconstructed from the measured four momenta of 22O and the emitted neutron. A sharp peak was observed at Edecay = 48 ± 3 keV, confirming the previous measurements. The measured partial longitudinal momentum distribution of 23O* showed the d-wave knockout character, providing a support for the Jπ assignment of 5/2+ for this state. The spectroscopic factor for the neutrons in 0d5/2 orbital was deduced, for the first time, to be C2S(0d5/2 = 3.7 ± 0.3 (preliminary by comparing with the result of Glauber model. The relatively large spectroscopic factor supports the N = 16 shell closure in the neutron drip-line nucleus 24O.

  20. Genotype X Environment Interaction for Yield of Pickling Cucumber in 24 U.S. Environments

    Directory of Open Access Journals (Sweden)

    Dia Mahendra

    2018-02-01

    Full Text Available Reliable yield performance is important in cucumber because seed companies prefer to market cultivars adapted to multiple rather than single regions of the U.S. Also, growers benefit by using a cultivar that performs well in many environments. Future performance of cultivars is also important. The objectives of the study were to (i evaluate the yield of cucumber genotypes over successive years and in different locations, and (ii identify cucumber genotypes with high stability for yield. A diverse set of 22 pickling genotypes was evaluated over 3 years (1986, 1987 and 1988 and in 7 locations across the United States. Yield traits were evaluated using once-over harvest and counting the number of fruit that were marketable, culled or oversize. Total yield, marketable yield (total minus culled fruit, early yield (number of oversize fruit, percent culls and fruit per plant were calculated. Data were analyzed with SASGxE and RGxE programs using SAS and R programming languages, respectively. There were strong effects of environment(E as well as genotype(G xE interaction for all traits. Genotypes ‘Regal F1’, ‘Calypso F1’, ‘Carolina F1’, ‘Gy 3’, ‘Gy 14’ and ‘Fremont F1’ had high marketable yield and medium to high stability for all traits. There was an advantage of hybrids over inbreds for trait performance. Hybrids fell into a single cluster with large prediction intervals. Based on the stability statistics and divisive clusters, it appears possible to breed stable cucumber genotypes with high yield. The genotype with highest performance for marketable yield, greatest stability for yield, lowest 1-R2 ratio value (diverse and representative were ‘Marbel F1’ and Gy 14.

  1. Reproductive hormones and metabolic syndrome in 24 testicular cancer survivors and their biological brothers.

    Science.gov (United States)

    Bandak, M; Jørgensen, N; Juul, A; Lauritsen, J; Kier, M G G; Mortensen, M S; Oturai, P S; Mortensen, J; Hojman, P; Helge, J W; Daugaard, G

    2017-07-01

    Testicular cancer survivors have impaired gonadal function and increased risk of metabolic syndrome when compared to healthy controls. However, because of the fetal etiology of testicular cancer, familial unrelated healthy men might not be an optimal control group. The objective of this study was to clarify if testicular cancer survivors have impaired gonadal function and increased risk of metabolic syndrome when compared to their biological brothers. A cross-sectional study of testicular cancer survivors (ClinicalTrials.gov number, NCT02240966) was conducted between 2014 and 2016. Of 158 testicular cancer survivors included, 24 had a biological brother who accepted to participate in the study. Serum levels of reproductive hormones and prevalence of metabolic syndrome according to International Diabetes Federation Criteria and National Cholesterol Education Program (Adult Treatment Panel III) criteria comprised the main outcome measures of the study. Median age was similar in testicular cancer survivors and their biological brothers [44 years (IQR 39-50) vs. 46 (40-53) years respectively (p = 0.1)]. In testicular cancer survivors, follow-up since treatment was 12 years (7-19). Serum levels of luteinizing hormone and follicle-stimulating hormone were elevated (p ≤ 0.001), while total testosterone, free testosterone, inhibin B and anti-Müllerian hormone were lower (p ≤ 0.001) in testicular cancer survivors than in their biological brothers. The prevalence of metabolic syndrome was similar and apart from HDL-cholesterol, which was lower in testicular cancer survivors (p = 0.01); there were no differences in the individual components of the metabolic syndrome between testicular cancer survivors and their brothers. In conclusion, gonadal function was impaired in testicular cancer survivors, while we did not detect any difference in the prevalence of metabolic syndrome between testicular cancer survivors and their biological brothers. © 2017 American Society of Andrology and European Academy of Andrology.

  2. Normal values of iodine - 131 uptake in 24 hours, in Rio Grande do Norte, Brazil

    International Nuclear Information System (INIS)

    Oliveira Filho, T.F. de; Oliveira, C.F.F. de

    Thorough clinical exams on all patients come to the radioisotope Laboratory at UFRN, where carried out attempting to select those patients with thyroids considered to be clinically normal. After wayne tests for hypo and hyperthyroidism were carried out, 100 patients were considered to be fit for the research. All of them had an impalpable and asympitomatic thyroid. Waynes clinical indices were precisely revealed in 93% of cases. It was concluded that the normal values of uptake of 131 I during the 24 hours in RGN varied between 14% and 44% [pt

  3. No consistent effects of prenatal or neonatal exposure to Spanish flu on late-life mortality in 24 developed countries

    DEFF Research Database (Denmark)

    Cohen, Alan; Tillinghast, J; Canudas-Romo, V

    2010-01-01

    We test the effects of early life exposure to disease on later health by looking for differences in late-life mortality in cohorts born around the 1918-1919 flu pandemic using data from the Human Mortality Database for 24 countries. After controlling for age, period, and sex effects, residual...

  4. Overall Low Extended-Spectrum Cephalosporin Resistance but high Azithromycin Resistance in Neisseria gonorrhoeae in 24 European Countries, 2015.

    Science.gov (United States)

    Cole, Michelle J; Spiteri, Gianfranco; Jacobsson, Susanne; Woodford, Neil; Tripodo, Francesco; Amato-Gauci, Andrew J; Unemo, Magnus

    2017-09-11

    Surveillance of Neisseria gonorrhoeae antimicrobial susceptibility in Europe is performed through the European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP), which additionally provides data to inform the European gonorrhoea treatment guideline; currently recommending ceftriaxone 500 mg plus azithromycin 2 g as first-line therapy. We present antimicrobial susceptibility data from 24 European countries in 2015, linked to epidemiological data of patients, and compare the results to Euro-GASP data from previous years. Antimicrobial susceptibility testing by MIC gradient strips or agar dilution methodology was performed on 2134 N. gonorrhoeae isolates and interpreted using EUCAST breakpoints. Patient variables associated with resistance were established using logistic regression to estimate odds ratios (ORs). In 2015, 1.7% of isolates were cefixime resistant compared to 2.0% in 2014. Ceftriaxone resistance was detected in only one (0.05%) isolate in 2015, compared with five (0.2%) in 2014. Azithromycin resistance was detected in 7.1% of isolates in 2015 (7.9% in 2014), and five (0.2%) isolates displayed high-level azithromycin resistance (MIC ≥ 256 mg/L) compared with one (0.05%) in 2014. Ciprofloxacin resistance remained high (49.4%, vs. 50.7% in 2014). Cefixime resistance significantly increased among heterosexual males (4.1% vs. 1.7% in 2014), which was mainly attributable to data from two countries with high cefixime resistance (~11%), however rates among men-who-have-sex-with-men (MSM) and females continued to decline to 0.5% and 1%, respectively. Azithromycin resistance in MSM and heterosexual males was higher (both 8.1%) than in females (4.9% vs. 2.2% in 2014). The association between azithromycin resistance and previous gonorrhoea infection, observed in 2014, continued in 2015 (OR 2.1, CI 1.2-3.5, p resistance and low overall resistance to ceftriaxone and cefixime. The low cephalosporin resistance may be attributable to the effectiveness of the currently recommended first-line dual antimicrobial therapy; however the high azithromycin resistance threatens the effectiveness of this therapeutic regimen. Whether the global use of azithromycin in mono- or dual antimicrobial therapy of gonorrhoea is contributing to the global increases in azithromycin resistance remains to be elucidated. The increasing cefixime resistance in heterosexual males also needs close monitoring.

  5. Disturbances of the sarcoplasmic reticulum and transverse tubular system in 24-h electrostimulated fast-twitch skeletal muscle

    DEFF Research Database (Denmark)

    Frías, J A; Cadefau, J A; Prats, C

    2005-01-01

    Chronic low-frequency stimulation of rabbit tibialis anterior muscle over a 24-h period induces a conspicuous loss of isometric tension that is unrelated to muscle energy metabolism (J.A. Cadefau, J. Parra, R. Cusso, G. Heine, D. Pette, Responses of fatigable and fatigue-resistant fibres of rabbit...

  6. Atrazine is not readily mineralised in 24 temperate soils regardless of pre-exposure to triazine herbicides

    International Nuclear Information System (INIS)

    Glaesner, Nadia; Baelum, Jacob; Strobel, Bjarne W.; Jacobsen, Carsten S.

    2010-01-01

    Mineralisation of atrazine in soil has been shown to depend on previous exposure of the herbicide. In this study, 24 Danish soils were collected and screened for potential to mineralise atrazine. Six soils were chosen, because they had never been exposed to atrazine, whereas 18 soils were chosen because of their history of application of atrazine or the related compound terbuthylazine. None of the 24 soils revealed a mineralisation potential of more than 4% of the added atrazine within a 60 day timeframe. In an atrazine adapted French soil, we found 60% mineralisation of atrazine in 30 days. Cattle manure was applied in order to boost the microbial activity, and a 2-3% increase in the atrazine mineralisation was found in some of the temperate soils, while in the highly adapted French soil it caused a 5% reduction. - The study highlights that pre-exposure of soils to triazine herbicides do not result in rapid mineralization in temperate soils.

  7. How does gatekeeper training improve suicide prevention for elderly people in nursing homes? A controlled study in 24 centres.

    Science.gov (United States)

    Chauliac, N; Brochard, N; Payet, C; Duclos, A; Terra, J-L

    2016-09-01

    The death rate due to suicide in elderly people is particularly high. As part of suicide selective prevention measures for at-risk populations, the WHO recommends training "gatekeepers". In order to assess the impact of gatekeeper training for members of staff, we carried out a controlled quasi-experimental study over the course of one year, comparing 12 nursing homes where at least 30% of the staff had undergone gatekeeper training with 12 nursing homes without trained staff. We collected data about the residents considered to be suicidal, their management further to being identified, as well as measures taken at nursing home level to prevent suicide. The two nursing home groups did not present significantly different characteristics. In the nursing homes with trained staff, the staff were deemed to be better prepared to approach suicidal individuals. The detection of suicidal residents relied more on the whole staff and less on the psychologist alone when compared to nursing homes without trained staff. A significantly larger number of measures were taken to manage suicidal residents in the trained nursing homes. Suicidal residents were more frequently referred to the psychologist. Trained nursing homes put in place significantly more suicide prevention measures at an institutional level. Having trained gatekeepers has an impact not only for the trained individuals but also for the whole institution where they work, both in terms of managing suicidal residents and routine suicide prevention measures. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  8. The Great Recession, Adolescent Smoking, and Smoking Inequalities: What Role Does Youth Unemployment Play in 24 European Countries?

    Science.gov (United States)

    Rathmann, Katharina; Pförtner, Timo-Kolja; Elgar, Frank J; Hurrelmann, Klaus; Richter, Matthias

    2017-11-01

    Conflicting evidence has been reported on smoking behavior among adults during times of economic downturn. No study has yet investigated young people's smoking and inequalities in smoking during economic recessions. This study examines the association between country-level youth unemployment due to the economic recession and adolescent smoking and smoking inequalities in Europe. The WHO collaborative "Health Behaviour in School-aged Children" study in 2009/2010 included 15-year-old adolescents from 24 European countries (N = 43 093). Socioeconomic position (SEP) was measured by the Family Affluence Scale. Logistic multilevel models were conducted. The absolute rate of youth unemployment in 2010 (during the recession) and the relative change rate in youth unemployment (2005/2006-2009/2010) were regressed on smoking and SEP inequalities in smoking in 2010, respectively. Youth unemployment rates were not significantly associated with overall smoking in adolescents. A higher absolute youth unemployment rate in 2010 related to lower likelihoods of smoking among middle (OR: 0.99; 95% CI: 0.98-0.99) and low affluent adolescents (OR: 0.99; 95% CI: 0.98-0.99) compared to high affluent adolescents. In contrast, an increase in youth unemployment (2005/2006-2009/2010) was not associated with overall likelihoods of smoking and inequalities in smoking. Our findings indicate that an increase in youth unemployment was not related to smoking and smoking inequalities. However, higher absolute levels of youth unemployment are related to lower likelihoods of smoking in lower SEP adolescents. Thus, smoking among vulnerable groups is more linked to the overall insecure circumstances and the affordability of cigarettes rather than to the economic recession itself. Economic recessions have often led to increases in adult and youth unemployment rates. Conflicting evidence has been reported on smoking behavior among adults during times of economic downturn. This study examines for the first time the impact of the economic recession on young people's smoking and socioeconomic inequalities in smoking. Findings highlight that rather than an increase in youth unemployment, the overall country-level youth unemployment rate is related to young people's tobacco use and particularly to lower odds in smoking among less affluent adolescents across Europe, a finding which is likely to be linked to the affordability of tobacco use. © The Author 2016. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  9. Provision of test results and posttest counseling at STD clinics in 24 health departments: U.S., 2007.

    Science.gov (United States)

    Begley, Elin; VanHandel, Michelle

    2012-01-01

    We determined the demographic and HIV test characteristics of tests conducted in CDC-funded sexually transmitted disease (STD) clinics with provision of test results and posttest counseling. We used CDC's HIV Counseling and Testing System data from 2007 for the 24 U.S. health departments that reported test-level data from STD clinics. We calculated and analyzed newly identified HIV positivity and the percentage of tests with provision of test results and posttest counseling (provision of posttest counseling), by demographic and HIV-related characteristics. Of 372,757 tests conducted among people without a previous HIV diagnosis by self-report, provision of posttest counseling was documented for 191,582 (51.4%) HIV tests overall and 1,922 (71.2%) newly identified HIV-positive test results. At these STD clinics, provision of posttest counseling varied by HIV serostatus, age, race/ethnicity, test type, and risk category; however, documentation of posttest counseling was missing for more than 20% of tests. The newly identified HIV positivity among all testers was 0.7%. One of the main goals of HIV counseling and testing is to inform people of their HIV status, because knowledge of one's HIV-positive serostatus can result in a reduction in risk behaviors and allow the person to access HIV medical care and treatment. STD clinics offering HIV testing may need to further their emphasis on increasing the proportion of clients who are provided posttest counseling and on improving documentation of this information.

  10. Reference intervals for stone risk factors in 24-h urine among healthy adults of the Han population in China.

    Science.gov (United States)

    Mai, Zanlin; Li, Xiaoxia; Cui, Zelin; Wu, Wenqi; Liu, Yongda; Ou, Lili; Liang, Yueping; Zhao, Zhijian; Liu, Yang; Mai, Xing; Zhu, Wei; Zhang, Tao; Cai, Chao; Yang, Houmeng; Zeng, Guohua

    2018-03-28

    The aim of the study was to establish reference intervals for 24-h urinary stone risk factors in the healthy Chinese Han population. From May 2013 to July 2014, we collected and analyzed 24-h urine samples from healthy adult Han population during a cross-sectional study across China. The protocol for analysis of 24-h urine included volume, pH, oxalate, citrate, sodium, potassium, chloride, calcium, phosphorous, creatinine, urate, magnesium, the ion activity products of calcium oxalate (AP(CaOx) indexs) and calcium phosphate (AP(CaP) indexs). We calculated the reference intervals according to the Clinical and Laboratory Standards Institute (CLSI) 2008 guidelines and compared them with those recorded in other studies. A total of 132 male and 123 female healthy subjects with a mean (SD, range) age of 52.4 (15.2, 19-89) years were eligible in the final analysis. Men had higher 24-h excretion of creatinine, calcium, urate and phosphorus and lower levels of citrate, magnesium, chloride, sodium and potassium than women. AP(CaOx) indexs and AP(CaP) indexs were significantly higher among men than women. When urinary findings were compared with the reference intervals, most of our data showed a high abnormality rate, especially for creatinine, calcium, citrate, magnesium, chloride, sodium and potassium. The present study revealed the normal metabolic status for stone risk factors of the Chinese Han population. It is therefore necessary for each country or region to define their own reference intervals for comparison of stone risk factors between patients and healthy subjects.

  11. Seasonal changes in 24-h patterns of suicide rates : a study on train suicides in The Netherlands

    NARCIS (Netherlands)

    van Houwelingen, CAJ; Beersma, DGM; Houwelingen, Cornelis A.J. van

    2001-01-01

    Background: Annual patterns in suicide rates, peaking near the summer solstice, are well documented. It has been suggested that day length or total hours of sunshine has an impact on suicide rates. If these environmental factors are involved, we would expect changes in the daily pattern of suicide

  12. Institution-to-institution mentoring to build capacity in 24 local US health departments: best practices and lessons learned.

    Science.gov (United States)

    Veatch, Maggie; Goldstein, Gail P; Sacks, Rachel; Lent, Megan; Van Wye, Gretchen

    2014-10-02

    Institutional mentoring may be a useful capacity-building model to support local health departments facing public health challenges. The New York City Department of Health and Mental Hygiene conducted a qualitative evaluation of an institutional mentoring program designed to increase capacity of health departments seeking to address chronic disease prevention. The mentoring program included 2 program models, a one-to-one model and a collaborative model, developed and implemented for 24 Communities Putting Prevention to Work grantee communities nationwide. We conducted semi-structured telephone interviews to assess grantees' perspectives on the effectiveness of the mentoring program in supporting their work. Two interviews were conducted with key informants from each participating community. Three evaluators coded and analyzed data using ATLAS.ti software and using grounded theory to identify emerging themes. We completed 90 interviews with 44 mentees. We identified 7 key program strengths: learning from the New York City health department's experience, adapting resources to local needs, incorporating new approaches and sharing strategies, developing the mentor-mentee relationship, creating momentum for action, establishing regular communication, and encouraging peer interaction. Participants overwhelmingly indicated that the mentoring program's key strengths improved their capacity to address chronic disease prevention in their communities. We recommend dissemination of the results achieved, emphasizing the need to adapt the institutional mentoring model to local needs to achieve successful outcomes. We also recommend future research to consider whether a hybrid programmatic model that includes regular one-on-one communication and in-person conferences could be used as a standard framework for institutional mentoring.

  13. No consistent effects of prenatal or neonatal exposure to Spanish flu on late-life mortality in 24 developed countries

    Directory of Open Access Journals (Sweden)

    Alan Cohen

    2010-04-01

    Full Text Available We test the effects of early life exposure to disease on later health by looking for differences in late-life mortality in cohorts born around the 1918-1919 flu pandemic using data from the Human Mortality Database for 24 countries. After controlling for age, period, and sex effects, residual mortality rates did not differ systematically for flu cohorts relative to surrounding cohorts. We calculate at most a 20-day reduction in life expectancy for flu cohorts; likely values are much smaller. Estimates of influenza incidence during the pandemic suggest that exposure was high enough for this to be a robust negative result.

  14. Effective M3 operator and relevant transitions in 24Al, 24Na, 34Cl, 38K, and 38Cl

    International Nuclear Information System (INIS)

    Brown, B.A.; Massen, S.E.; Chung, W.; Wildenthal, B.H.; Shibata, T.A.

    1980-01-01

    Theoretical calculations are presented for the magnetic octupole electromagnetic matrix elements in light nuclei. Shell-model wave functions are used to calculate the M3 matrix elements for the cases 24 Al 1 + → 4 + , 24 Na 1 + → 4 + , 34 Cl 3 + → 0 + , 38 K 0 + → 3 + , and 38 Cl 5 - → 2 - . The radial matrix elements are calculated with harmonic-oscillator and spherical Hartree-Fock potentials. The comparison of the calculated and experimental matrix elements is expressed in terms of effective spin g factors. Theoretical calculations for the core-polarization corrections are presented and relations between the E2 core-polarization charge and the M3 effective spin g factors are derived

  15. Gender specific trends in alcohol use: cross-cultural comparisons from 1998 to 2006 in 24 countries and regions

    NARCIS (Netherlands)

    Simons-Morton, B.; Farhat, T.; Bogt, T.F.M. ter; Hublet, A.; Kuntsche, E.N.; Gabhainn, S.N.; Godeau, E.; Kokkevi, A.

    2009-01-01

    Objective: To examine trends in the prevalence of monthly alcohol use and lifetime drunkenness among 15 year olds in 20 European countries, the Russian Federation, Israel, the United States of America, and Canada. Methods: Alcohol use prevalence and drunkenness were assessed in the Health Behavior

  16. The Cause of Unexpected Acute Abdomen and Intra-Abdominal Hemorrhage in 24-Week Pregnant Woman: Bochdalek Hernia.

    Science.gov (United States)

    Koca, Yavuz Savas; Barut, Ibrahim; Yildiz, İhsan; Yazkan, Rasih

    2016-01-01

    Bochdalek hernia (BH) is the most common type of congenital diaphragm hernia and is rarely seen in adults. In adult patients, BH often remains asymptomatic or presents with nondiagnostic symptoms and may lead to complications, though rarely. The necrosis and perforations occurring in the hernia may lead to mortality. In this report, we present a 34-year-old pregnant woman at 24 gestational weeks who presented with Bochdalek hernia causing gastric volvulus associated with perforation and intra-abdominal hemorrhage associated with splenic rupture.

  17. An enhanced postnatal autoimmune profile in 24 week-old C57BL/6 mice developmentally exposed to TCDD

    International Nuclear Information System (INIS)

    Mustafa, A.; Holladay, S.D.; Goff, M.; Witonsky, S.G.; Kerr, R.; Reilly, C.M.; Sponenberg, D.P.; Gogal, R.M.

    2008-01-01

    Developmental exposure of mice to the environmental contaminant and AhR agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), causes persistent postnatal suppression of T cell-mediated immune responses. The extent to which prenatal TCDD may induce or exacerbate postnatal autoimmune disease remains unknown. In the present study, time-pregnant high affinity AhR C57BL/6 mice received a single oral administration of 0, 2.5, or 5 μg/kg TCDD on gestation day (gd) 12. Offspring of these mice (n = 5/gender/treatment) were evaluated at 24 weeks-of-age and showed considerable immune dysregulation that was often gender-specific. Decreased thymic weight and percentages of CD4 + CD8 + thymocytes, and increased CD4 + CD8 - thymocytes, were present in the female but not male offspring. Males but not females showed decreased CD4 - CD8 + T cells, and increased Vβ3 + and Vβ17a + T cells, in the spleen. Males but not females also showed increased percentages of bone marrow CD24 - B220 + B cell progenitors. Antibody titers to dsDNA, ssDNA and cardiolipin displayed increasing trends in both male and female mice, reaching significance for anti-dsDNA in both genders and for ssDNA in males at 5 μg/kg TCDD. Immunofluorescent staining of IgG and C3 deposition in kidney glomeruli increased in both genders of prenatal TCDD-exposed mice, suggestive of early stages of autoimmune glomerulonephritis. Collectively, these results show that exposure to TCDD during immune system development causes persistent humoral immune dysregulation as well as altered cell-mediated responses, and induces an adult profile of changes suggestive of increased risk for autoimmune disease

  18. Reduction in 24-Hour Plasma Testosterone Levels in Subjects Who Showered 15 or 30 Minutes After Application of Testosterone Gel

    NARCIS (Netherlands)

    de Ronde, W.; Vogel, S.; Bui, H.N.; Heijboer, A.C.

    2011-01-01

    Study Objective. To investigate whether showering, to prevent the involuntary transfer of testosterone to others through skin contact, either 15 or 30 minutes after application of testosterone gel would significantly affect plasma testosterone levels. Design. Prospective 3-way crossover trial.

  19. Reaction mechanisms in 24.3 MeV/nucleon 238U induced reactions through a comprehensive study of fission

    International Nuclear Information System (INIS)

    Chbihi, A.; Galin; Guerreau, D.; Lewitowicz, M.; Morjean, M.; Pouthas, J.; Piasecki, E.; Kordyasz, A.; Iwanicki, J.; Jastrzebski, J.; Pienkowski, L.; Crema, E.; Gatty, B.; Jacquet, D.; Muchorowska, M.

    1994-01-01

    Nuclear reaction mechanisms for system characterized by very different asymmetries (U+C, Si, Ni, Au) have been investigated at 24.3 MeV/nucleon, using as observables both the fission products and the neutron multiplicity. It is clearly observed that the fusion process-whatever its completeness- can only occur with rather light target nuclei, indicating the persistence of potential energy effects much above the interaction barrier. (authors). 22 refs., 1 fig

  20. A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs.

    Science.gov (United States)

    Urfer, Silvan R; Kaeberlein, Tammi L; Mailheau, Susan; Bergman, Philip J; Creevy, Kate E; Promislow, Daniel E L; Kaeberlein, Matt

    2017-04-01

    Age is the single greatest risk factor for most causes of morbidity and mortality in humans and their companion animals. As opposed to other model organisms used to study aging, dogs share the human environment, are subject to similar risk factors, receive comparable medical care, and develop many of the same age-related diseases humans do. In this study, 24 middle-aged healthy dogs received either placebo or a non-immunosuppressive dose of rapamycin for 10 weeks. All dogs received clinical and hematological exams before, during, and after the trial and echocardiography before and after the trial. Our results showed no clinical side effects in the rapamycin-treated group compared to dogs receiving the placebo. Echocardiography suggested improvement in both diastolic and systolic age-related measures of heart function (E/A ratio, fractional shortening, and ejection fraction) in the rapamycin-treated dogs. Hematological values remained within the normal range for all parameters studied; however, the mean corpuscular volume (MCV) was decreased in rapamycin-treated dogs. Based on these results, we will test rapamycin on a larger dog cohort for a longer period of time in order to validate its effects on cardiac function and to determine whether it can significantly improve healthspan and reduce mortality in companion dogs.

  1. Institution-to-Institution Mentoring to Build Capacity in 24 Local US Health Departments: Best Practices and Lessons Learned

    OpenAIRE

    Veatch, Maggie; Goldstein, Gail P.; Sacks, Rachel; Lent, Megan; Van Wye, Gretchen

    2014-01-01

    Introduction Institutional mentoring may be a useful capacity-building model to support local health departments facing public health challenges. The New York City Department of Health and Mental Hygiene conducted a qualitative evaluation of an institutional mentoring program designed to increase capacity of health departments seeking to address chronic disease prevention. The mentoring program included 2 program models, a one-to-one model and a collaborative model, developed and implemented ...

  2. Mucopolysaccharidosis: Cardiologic features and effects of enzyme-replacement therapy in 24 children with MPS I, II and VI

    NARCIS (Netherlands)

    M.M.M.G. Brands (Marion); I.M.E. Frohn-Mulder (Ingrid); M.L.C. Hagemans (Marloes); W.C.J. Hop (Wim); E. Oussoren (E.); W.A. Helbing (Willem); A.T. van der Ploeg (Ans)

    2013-01-01

    textabstractWe determined the cardiologic features of children with MPS I, II and VI, and evaluated the effect of enzyme-replacement therapy (ERT) on cardiac disease. Twenty-four children aged 1-18 years with MPS I, II or VI were prospectively evaluated with echocardiogram and electrocardiogram from

  3. Pseudorapidity distribution of shower particles in 24Mg-emulsion collisions at 4.5 A GeV/c

    International Nuclear Information System (INIS)

    Meng Cairong; Li Xiaolin; Duan Maiying

    2004-01-01

    The pseudorapidity distribution of shower particles produced in the 24 Mg-emulsion collisions at 4.5 A GeV/c is reported in this paper. The dependences of the distribution width and the peak position on the target size are observed. The pseudorapidity distribution of shower particles for the events with low target multiplicity (light target) is narrower than that with high target multiplicity (heavy target). The maximum probability pseudorapidity for light target is greater than that for heavy target. The experimental data is analyzed by using the cylinder model suggested by Liu et al. The Monte Carlo results based on Liu's cylinder model are approximately in agreement with the experimental tendency and fluctuation. (author)

  4. Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls.

    Science.gov (United States)

    Pinzer, T C; Tietz, E; Waldmann, E; Schink, M; Neurath, M F; Zopf, Y

    2018-04-01

    Histamine intolerance is thought to trigger manifold clinical symptoms after ingesting histamine-rich food due to reduced activity of diamine oxidase (DAO). No study has hitherto systematically assessed daily fluctuations of histamine levels and DAO activities in symptomatic patients. The aim of the study was to investigate the presence of histamine intolerance, to therefore establish day profiles of histamine levels and DAO activities, and to compare the results between patients with suspected histamine intolerance, food allergy and healthy controls. We determined day profiles of histamine plasma levels and DAO serum activities in 33 patients with suspected histamine intolerance, in 21 patients with proven food allergy and in 10 healthy control patients. Clinical symptoms, food intolerances and further clinical and laboratory chemical parameters were evaluated. Twenty-four percent (8 of 33) suspected histamine-intolerant patients showed elevated histamine levels during the day. That might be caused by constantly and significantly reduced DAO activities in these patients compared to food-allergic and control patients. The remaining 25 patients presented normal histamine levels and DAO activities, but an increased prevalence of multiple food intolerances compared to the other subgroup of suspected histamine-intolerants. There was no correlation between subjective complaints and serological histamine parameters in patients with suspected histamine intolerance. We determined by daily profiling that decreased DAO activities correlated with elevated histamine levels in a subgroup of suspected histamine-intolerants. This finding discriminates these patients from food intolerant individuals with similar clinical symptoms and strongly suggests the presence of histamine intolerance. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

  5. Reconstrucción mamaria con expansor tisular e implante: Indicaciones y experiencia en 24 casos Breast reconstruction with tissue expander: Indications and experience in 24 cases

    Directory of Open Access Journals (Sweden)

    C. Gutiérrez Gómez

    2012-12-01

    Full Text Available En la actualidad, la reconstrucción mamaria forma parte integral del tratamiento del cáncer de mama; la selección de la paciente es crítica para obtener resultados satisfactorios. El presente trabajo recoge nuestra experiencia en reconstrucción mamaria con expansión tisular e implantes, haciendo hincapié en la selección de las pacientes candidatas a este método reconstructivo. Revisamos las reconstrucciones mamarias realizadas en un período comprendido entre los años 1998 y 2008 por la misma cirujana, analizando factores como tipo de mastectomía, edad, tiempo de la reconstrucción (inmediata o diferida, causa de la mastectomía, tipo de expansor y prótesis utilizados, complicaciones y satisfacción de las pacientes. En todas excepto en una, la reconstrucción se realizó en dos tiempos operatorios; durante el primero se hizo la colocación del expansor tisular y en el segundo, el cambio por la prótesis mamaria definitiva. Se realizaron un total de 24 reconstrucciones mamarias en 19 pacientes en el período de 10 años revisado, 14 unilaterales y 5 bilaterales. Las complicaciones presentadas en este grupo de pacientes fueron del 16,6 %. El seguimiento de las pacientes fue de 2 a 10 años. Solamente en 1 caso de cuadrantectomía, se realizó la reconstrucción de forma diferida por antecedente de radioterapia (4,1 %. En nuestra opinión, la reconstrucción mamaria con expansor tisular e implante es un procedimiento seguro, reproducible y con bajo índice de complicaciones, sin el inconveniente añadido de ocasionar morbilidad en el a área donante.Nowadays, breast reconstruction is part of breast carcinoma treatment; patient's selection plays an important role in satisfactory results. The present paper reports our experience in breast reconstruction with tissue expander/implant and emphasizes the importance of choosing the candidates for this method of reconstruction. We review the breast reconstructions realized in a 10 year period (1998-2008 by the same surgeon. We analyzed factors like type of mastectomy, age, time of the reconstruction (immediate or delayed, etiology, tissue expander and implant used complications and patients´ satisfaction. All the patients except one underwent breast reconstruction in two stages, first submuscular tissue expander, and second reconstruction replacement of tissue expander with implant. A total of 24 breast were reconstructed in 19 patients using tissue expander/implant in a 10 years period, 14 unilateral and 5 bilateral. In terms of complications, they were present n 16,6 % cases. The follow up period was between 2 and 10 years. There was only 1 patient with previous quadrantectomy who received radiotherapy (4,1 %. In our opinion, breast reconstruction with tissue expander/implant remains a safe and reliable method with minimal complications and without morbidity at the donor site.

  6. Risk-benefit evaluation of fish from Chinese markets: Nutrients and contaminants in 24 fish species from five big cities and related assessment for human health

    Energy Technology Data Exchange (ETDEWEB)

    Du, Zhen-Yu, E-mail: zdu@nifes.no [National Institute of Nutrition and Seafood Research (NIFES), N-5817 Bergen (Norway); Zhang, Jian [National Institute of Nutrition and Seafood Research (NIFES), N-5817 Bergen (Norway); Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, 100050 (China); Department of Biomedicine, University of Bergen (Norway); Wang, Chunrong; Li, Lixiang; Man, Qingqing [Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, 100050 (China); Lundebye, Anne-Katrine; Froyland, Livar [National Institute of Nutrition and Seafood Research (NIFES), N-5817 Bergen (Norway)

    2012-02-01

    The risks and benefits of fish from markets in Chinese cities have not previously been fully evaluated. In the present study, 24 common fish species with more than 400 individual samples were collected from markets from five big Chinese cities in 2007. The main nutrients and contaminants were measured and the risk-benefit was evaluated based on recommended nutrient intakes and risk level criteria set by relevant authorities. The comprehensive effects of nutrients and contaminants in marine oily fish were also evaluated using the data of two related human dietary intervention trials performed in dyslipidemic Chinese men and women in 2008 and 2010, respectively. The results showed that concentrations of contaminants analyzed including DDT, PCB{sub 7}, arsenic and cadmium were much lower than their corresponding maximum limits with the exception of the mercury concentration in common carp. Concentrations of POPs and n-3 LCPUFA, mainly EPA and DHA, were positively associated with the lipid content of the fish. With a daily intake of 80-100 g marine oily fish, the persistent organic pollutants in fish would not counteract the beneficial effects of n-3 LCPUFA in reducing cardiovascular disease (CVD) risk markers. Marine oily fish provided more effective protection against CVD than lean fish, particularly for the dyslipidemic populations. The risk-benefit assessment based on the present daily aquatic product intake in Chinese urban residents (44.9 and 62.3 g for the average values for all cities and big cities, respectively) indicated that fish, particularly marine oily fish, can be regularly consumed to achieve optimal nutritional benefits from n-3 LCPUFA, without causing significant contaminant-related health risks. However, the potential health threat from contaminants in fish should still be emphasized for the populations consuming large quantities of fish, particularly wild fish. - Highlights: Black-Right-Pointing-Pointer We collected 24 fish species with more than 400 individual samples from five big Chinese cities. Black-Right-Pointing-Pointer The health risk-benefit was evaluated based on the nutrients and contaminants content in fish. Black-Right-Pointing-Pointer Two human trials were performed to evaluate the effects of contaminated fish on CVD prevalence. Black-Right-Pointing-Pointer Contaminants in these fish couldn't alleviate the benefits of fish n-3 LCPUFA in CVD prevention. Black-Right-Pointing-Pointer These fish in China can be regularly consumed without causing contaminant-related health risks.

  7. Determination of reference intervals and comparison of venous blood gas parameters using standard and non-standard collection methods in 24 cats.

    Science.gov (United States)

    Bachmann, Karin; Kutter, Annette Pn; Schefer, Rahel Jud; Marly-Voquer, Charlotte; Sigrist, Nadja

    2017-08-01

    Objectives The aim of this study was to determine in-house reference intervals (RIs) for venous blood analysis with the RAPIDPoint 500 blood gas analyser using blood gas syringes (BGSs) and to determine whether immediate analysis of venous blood collected into lithium heparin (LH) tubes can replace anaerobic blood sampling into BGSs. Methods Venous blood was collected from 24 healthy cats and directly transferred into a BGS and an LH tube. The BGS was immediately analysed on the RAPIDPoint 500 followed by the LH tube. The BGSs and LH tubes were compared using paired t-test or Wilcoxon matched-pairs signed-rank test, Bland-Altman and Passing-Bablok analysis. To assess clinical relevance, bias or percentage bias between BGSs and LH tubes was compared with the allowable total error (TEa) recommended for the respective parameter. Results Based on the values obtained from the BGSs, RIs were calculated for the evaluated parameters, including blood gases, electrolytes, glucose and lactate. Values derived from LH tubes showed no significant difference for standard bicarbonate, whole blood base excess, haematocrit, total haemoglobin, sodium, potassium, chloride, glucose and lactate, while pH, partial pressure of carbon dioxide and oxygen, actual bicarbonate, extracellular base excess, ionised calcium and anion gap were significantly different to the samples collected in BGSs ( P glucose and lactate can be made based on blood collected in LH tubes and analysed within 5 mins. For pH, partial pressure of carbon dioxide and oxygen, extracellular base excess, anion gap and ionised calcium the clinically relevant alterations have to be considered if analysed in LH tubes.

  8. Predictors of placebo group decline in the Alzheimer's disease Assessment Scale-cognitive subscale (ADAS-Cog) in 24 week clinical trials of Alzheimer's disease.

    Science.gov (United States)

    Irizarry, Michael C; Webb, David J; Bains, Chanchal; Barrett, Steven J; Lai, Robert Y; Laroche, Janette P; Hosford, David; Maher-Edwards, Gareth; Weil, John G

    2008-07-01

    One limitation of several recent 24 week Alzheimer's disease (AD) clinical trials was the lack of cognitive decline detected by the AD Assessment Scale-cognitive subscale (ADAS-cog) in the placebo groups, possibly obscuring true medication effects. Data from 733 individuals in the placebo arms of six AD clinical trials performed 1996-1997 were pooled to examine the relationship of clinical, demographic, and genetic characteristics with the 24 week change in ADAS-cog. Baseline cognitive and functional status and the screening-to-baseline change in ADAS-cog were the strongest independent predictors of the 24 week change in ADAS-cog. The ADAS-cog did not detect progression in patients with mild dementia (screening Mini-Mental State Exam, MMSE, >or=20). The change in ADAS-cog from screening to baseline was inversely correlated with the 24 week change score; it was more difficult to detect cognitive decline at 24 weeks if individuals markedly worsened from screening to baseline. The effects of baseline MMSE and screening-to-baseline change in ADAS-cog generalized to the placebo group (N=106) of another AD study performed in 2004-2005. Overcoming lack of placebo decline in AD clinical trials will require scales more sensitive to cognitive decline in mild AD and strategies to reduce within-person variability in outcome measures.

  9. Long-Term Outcome and MGMT as a Predictive Marker in 24 Patients With Atypical Pituitary Adenomas and Pituitary Carcinomas Given Treatment With Temozolomide

    DEFF Research Database (Denmark)

    Bengtsson, Daniel; Schrøder, Henrik Daa; Andersen, Marianne

    2015-01-01

    CONTEXT/OBJECTIVE: Locally aggressive pituitary tumors (LAPT) and pituitary carcinomas respond poorly to conventional therapy and cytotoxic drugs. Temozolomide (TMZ) is an oral alkylating drug with good tolerability, approved for treatment of malignant gliomas. The experience of its use in pituit......CONTEXT/OBJECTIVE: Locally aggressive pituitary tumors (LAPT) and pituitary carcinomas respond poorly to conventional therapy and cytotoxic drugs. Temozolomide (TMZ) is an oral alkylating drug with good tolerability, approved for treatment of malignant gliomas. The experience of its use...

  10. Assessing the Universal Structure of Personality in Early Adolescence: The NEO-PI-R and NEO-PI-3 in 24 Cultures

    Science.gov (United States)

    De Fruyt, Filip; De Bolle, Marleen; McCrae, Robert R.; Terracciano, Antonio; Costa, Paul T., Jr.

    2009-01-01

    The structure and psychometric characteristics of the NEO Personality Inventory-3 (NEO-PI-3), a more readable version of the Revised NEO Personality Inventory (NEO-PI-R), are examined and compared with NEO-PI-R characteristics using data from college student observer ratings of 5,109 adolescents aged 12 to 17 years from 24 cultures. Replacement…

  11. A comprehensive study of fission in 24.3 MeV/nucleon U reactions induced on C, Si, Ni, Au targets

    International Nuclear Information System (INIS)

    Piasecki, E.; Pienkowski, L.; Czosnyka, T.; Iwanicki, J.; Muchorowska, M.; Tucholski, A.; Czarnacki, W.; Chbihi, A.; Galin, J.; Crema, E.; Sao Paulo Univ., SP

    1995-01-01

    Fission is a powerful tool for studying the primary reaction mechanisms in nucleus-nucleus collisions involving at least one fissionable nucleus. This is well shown when an additional information on the violence of the collision is provided by a totally independent observable such as the neutron multiplicity. The mass asymmetry in the entrance channel and the impact parameter are shown to have a decisive influence on the fate of the collision leading to either fusion or a two-body deeply inelastic reaction, analogous to what is known at lower bombarding energies. The experimental approach allows also to single out electromagnetic fission of U after interaction with Au and to provide some characteristics of such a process. (author)

  12. Textual poaching, gamekeeping and the counter-stereotype: US and Norwegian online fans’ perceptions of positive portrayals of Muslims in 24

    OpenAIRE

    Halse, Rolf E. S.

    2014-01-01

    In the analogue era, fan studies explored localized resistance within fan communities’ cultural practices, examining how this might lead to new understandings of gender, sexuality, and race. However, there has been less work that examines the consequences fans’ cultural practices using digital media have for the cultural politics of ‘poaching’. The current article presents a study of online fans’ perceptions of positively depicted Muslim characters from the Middle East in the t...

  13. Impact of mother tongue and gender on overweight, obesity and extreme obesity in 24,989 Viennese children/adolescents (2-16 years).

    Science.gov (United States)

    Segna, Daniel; Widhalm, Harald; Pandey, Maitrayee P; Zehetmayer, Sonja; Dietrich, Sabine; Widhalm, Kurt

    2012-11-01

    The present survey aims at determining the prevalence of extreme obesity (defined as a body mass index (BMI) ≥ 99.5th percentile) for the first time in Austria and at investigating the relationship between weight status and mother tongue in a representative Viennese sample of 24,989 children and adolescents (2-16 years) with a percentage of approximately 46 % of migration background.Directly measured anthropometric data on body weight and height were collected and BMI was calculated. Prevalence of overweight, obesity and extreme obesity was determined for every subgroup according to mother tongue using the German national reference criteria by Kromeyer-Hauschild et al.In this sample, 2.1 % of all children and adolescents had to be classified as being extremely obese. More boys (2.3 %) than girls (1.9 %) suffered from extreme obesity (p = 0.048). Total 1.7 % of children and adolescents with German as their native language, 2.5 % of Turkish native speakers and 2.9 % of children and adolescents with another mother tongue were extremely obese (p ≤ 0.001). The highest prevalence of overweight or obesity was found in Turkish-native-speaking children and adolescents (p ≤ 0.001), whereas the lowest one was found in German-native-speaking children and adolescents (p ≤ 0.001).This large study clearly shows that extreme obesity is a common disease and largely neglected. Apparently, another native language than German, as an indicator for a migration background, may be associated with a substantially higher probability for the development of extreme obesity in Vienna, Austria. Thus, effective preventive measures to overcome obesity are urgently needed.

  14. An inverse association between magnesium in 24-h urine and cardiovascular risk factors in middle-aged subjects in 50 CARDIAC Study populations.

    Science.gov (United States)

    Yamori, Yukio; Sagara, Miki; Mizushima, Shunsaku; Liu, Longjian; Ikeda, Katsumi; Nara, Yasuo

    2015-03-01

    Serum, plasma and dietary magnesium (Mg) have been reported to be inversely associated with cardiovascular disease risk factors. We examined the associations between the 24-h urinary Mg/creatinine (Cre) ratio and cardiovascular disease risk factors, such as body mass index (BMI), blood pressure (BP), serum total cholesterol (TC) and prevalence of obesity, hypertension and hypercholesterolemia. A cross-sectional analysis was conducted among 4211 participants (49.7% women) aged 48-56 years in 50 population samples from 22 countries in the World Health Organization-coordinated Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study (1985-1994). In linear regression analyses, Mg/Cre ratio was inversely associated with BMI, systolic BP (SBP), diastolic BP (DBP) and TC (P for linear trend <0.001 for each). These associations were not markedly altered by adjustment for traditional risk factors, urinary markers or cohort effects. Multivariate-adjusted mean values for the subjects in the highest Mg/Cre ratio quintile were 6.3, 3.4, 5.3 and 4.6% lower than those for the subjects in the lowest quintile for BMI, SBP, DBP and TC (P < 0.001, respectively). The prevalence of obesity, hypertension and hypercholesterolemia was 2.10 (95% confidence interval: 1.50, 2.95), 1.55 (1.25, 1.92) and 2.06 (1.63, 2.62) times higher (P < 0.001, respectively) among the subjects in the lowest Mg/Cre ratio quintile than in the subjects in the highest quintile. These associations were not appreciably altered by adjustment for potential confounding variables. In conclusion, higher 24-h urinary Mg/Cre ratio was associated with lower cardiovascular disease risk factors, including BMI, BP, TC, obesity, hypertension and hypercholesterolemia.

  15. Risk–benefit evaluation of fish from Chinese markets: Nutrients and contaminants in 24 fish species from five big cities and related assessment for human health

    International Nuclear Information System (INIS)

    Du, Zhen-Yu; Zhang, Jian; Wang, Chunrong; Li, Lixiang; Man, Qingqing; Lundebye, Anne-Katrine; Frøyland, Livar

    2012-01-01

    The risks and benefits of fish from markets in Chinese cities have not previously been fully evaluated. In the present study, 24 common fish species with more than 400 individual samples were collected from markets from five big Chinese cities in 2007. The main nutrients and contaminants were measured and the risk–benefit was evaluated based on recommended nutrient intakes and risk level criteria set by relevant authorities. The comprehensive effects of nutrients and contaminants in marine oily fish were also evaluated using the data of two related human dietary intervention trials performed in dyslipidemic Chinese men and women in 2008 and 2010, respectively. The results showed that concentrations of contaminants analyzed including DDT, PCB 7 , arsenic and cadmium were much lower than their corresponding maximum limits with the exception of the mercury concentration in common carp. Concentrations of POPs and n-3 LCPUFA, mainly EPA and DHA, were positively associated with the lipid content of the fish. With a daily intake of 80–100 g marine oily fish, the persistent organic pollutants in fish would not counteract the beneficial effects of n-3 LCPUFA in reducing cardiovascular disease (CVD) risk markers. Marine oily fish provided more effective protection against CVD than lean fish, particularly for the dyslipidemic populations. The risk–benefit assessment based on the present daily aquatic product intake in Chinese urban residents (44.9 and 62.3 g for the average values for all cities and big cities, respectively) indicated that fish, particularly marine oily fish, can be regularly consumed to achieve optimal nutritional benefits from n-3 LCPUFA, without causing significant contaminant-related health risks. However, the potential health threat from contaminants in fish should still be emphasized for the populations consuming large quantities of fish, particularly wild fish. - Highlights: ► We collected 24 fish species with more than 400 individual samples from five big Chinese cities. ► The health risk–benefit was evaluated based on the nutrients and contaminants content in fish. ► Two human trials were performed to evaluate the effects of contaminated fish on CVD prevalence. ► Contaminants in these fish couldn't alleviate the benefits of fish n-3 LCPUFA in CVD prevention. ► These fish in China can be regularly consumed without causing contaminant-related health risks.

  16. Phenotypic features of carbohydrate sulfotransferase 3 (CHST3) deficiency in 24 patients: congenital dislocations and vertebral changes as principal diagnostic features.

    Science.gov (United States)

    Unger, Sheila; Lausch, Ekkehart; Rossi, Antonio; Mégarbané, Andre; Sillence, David; Alcausin, Melanie; Aytes, Antonio; Mendoza-Londono, Roberto; Nampoothiri, Sheela; Afroze, Bushra; Hall, Bryan; Lo, Ivan F M; Lam, Stephen T S; Hoefele, Julia; Rost, Imma; Wakeling, Emma; Mangold, Elisabeth; Godbole, Komudi; Vatanavicharn, Nithiwat; Franco, Luis M; Chandler, Kate; Hollander, Sophia; Velten, Tanja; Reicherter, Kerstin; Spranger, Jürgen; Robertson, Stephen; Bonafé, Luisa; Zabel, Bernhard; Superti-Furga, Andrea

    2010-10-01

    We recently reported on the deficiency of carbohydrate sulfotransferase 3 (CHST3; chondroitin-6-sulfotransferase) in six subjects diagnosed with recessive Larsen syndrome or humero-spinal dysostosis [Hermanns et al. (2008); Am J Hum Genet 82:1368-1374]. Since then, we have identified 17 additional families with CHST3 mutations and we report here on a series of 24 patients in 23 families. The diagnostic hypothesis prior to molecular analysis had been: Larsen syndrome (15 families), humero-spinal dysostosis (four cases), chondrodysplasia with multiple dislocations (CDMD "Megarbane type"; two cases), Desbuquois syndrome (one case), and spondylo-epiphyseal dysplasia (one case). In spite of the different diagnostic labels, the clinical features in these patients were similar and included dislocation of the knees and/or hips at birth, clubfoot, elbow joint dysplasia with subluxation and limited extension, short stature, and progressive kyphosis developing in late childhood. The most useful radiographic clues were the changes of the lumbar vertebrae. Twenty-four different CHST3 mutations were identified; 16 patients had homozygous mutations. We conclude that CHST3 deficiency presents at birth with congenital dislocations of knees, hips, and elbows, and is often diagnosed initially as Larsen syndrome, humero-spinal dysostosis, or chondrodysplasia with dislocations. The incidence of CHST3 deficiency seems to be higher than assumed so far. The clinical and radiographic pattern (joint dislocations, vertebral changes, normal carpal age, lack of facial flattening, and recessive inheritance) is characteristic and distinguishes CHST3 deficiency from other disorders with congenital dislocations such as filamin B-associated dominant Larsen syndrome and Desbuquois syndrome. Copyright © 2010 Wiley-Liss, Inc.

  17. The Influence of Prosocial Norms and Online Network Structure on Prosocial Behavior : An Analysis of Movember’s Twitter Campaign in 24 Countries

    NARCIS (Netherlands)

    van den Broek, Tijs Adriaan; Need, Ariana; Ehrenhard, Michel Léon; Priante, Anna; Hiemstra, Djoerd

    2015-01-01

    Sociological research points at norms and social networks as antecedents of prosocial behavior. To date, the literature remains undecided on how these factors jointly influence prosocial behavior. Furthermore, the use of social media by campaign organizations may change the need for formal networks

  18. Time bound changes (in 24 h in human sperm motility and level of calcium and magnesium in seminal plasma

    Directory of Open Access Journals (Sweden)

    J. Valsa

    2016-09-01

    Level of calcium (27.2 mg/dl and magnesium (13.54 mg/dl in seminal plasma did not show any significant changes during study period from that of at ½ h. The study concluded that electrolytes under study were not responsible for the decrease in motility during study period.

  19. Assessing the Universal Structure of Personality in Early Adolescence: The NEO-PI-R and NEO-PI-3 in 24 cultures

    Czech Academy of Sciences Publication Activity Database

    De Fruyt, F.; De Bolle, M.; Aguilar-Vafaie, M.E.; Ahn, Ch.; Ahn, H.; Alcalay, L.; Allik, J.; Avdeyeva, T.V.; Blatný, Marek; Bratko, D.; Brunner-Sciarra, M.; Cain, T.R.; Chittcharat, N.; Crawford, J.T.; Fehr, R.; Ficková, E.; Gelfand, M.J.; Gulgoz, S.; Hřebíčková, Martina; Jussim, L.; Klinkosz, W.; Knežević, G.; Leibovich de Figueroa, N.; Lima, M.P.; Löckenhoff, C.E.; Martin, T.A.; Marušić, I.; Mastor, K.A.; Nakazato, K.; Nansubuga, F.; Porrata, J.; Purić, D.; Realo, A.; Reátegui, N.; Rolland, J.-P.; Schmidt, V.; Sekowski, A.; Shakespeare-Finch, J.; Shimonaka, Y.; Simonetti, F.; Siuta, J.; Szmigielska, B.; Vanno, V.; Wang, L.; Yik, M.

    2009-01-01

    Roč. 16, č. 3 (2009), s. 301-311 ISSN 1073-1911 R&D Projects: GA ČR GA406/07/1561 Institutional research plan: CEZ:AV0Z70250504 Keywords : adolescence * Five-Factor Model * cross-cultural * personality * observer ratings Subject RIV: AN - Psychology Impact factor: 1.974, year: 2009

  20. Fatigue Strength and Related Characteristics of Aircraft Joints I : Comparison of Spot-Weld and Rivet Patterns in 24s-t Alclad and 75s-t Alclad

    Science.gov (United States)

    Russell, H W; Jackson, L R; Grover, H J; Beaver, W W

    1944-01-01

    Report contains detailed results of a number of fatigue tests on spot-welded joints in aluminum alloys. The tests described include: (1) fatigue tests on spot-welded lap joints in sheets of unequal thickness of alclad 24s-t. These tests indicate that the fatigue strength of a spot-welded joint in sheets of two different gages is slightly higher than that of a similar joint in two sheets of the thinner gage but definitely lower than that of a similar joint in two sheets of the thicker gage. (2) Fatigue tests on spot-welded alclad 75s-t spot-welded lap-joint specimens of alclad 75s-t were not any stronger in fatigue than similar specimens of alclad 24s-t. (3) Fatigue tests on lap-joint specimens spot -welded after various surface preparations--these included ac welding wire-brushed surfaces, dc welding wire-brushed surfaces, and dc welding chemically cleaned surfaces. While the ac welds were strongest statically, the dc welds on wire-brushed surfaces were strongest in fatigue. Specimens prepared in this way were very nearly as strong as the best riveted specimens tested for comparison. (4) Fatigue tests on specimens spot-welded with varying voltage so as to include a wide range of static spot-weld strengths. The fatigue strengths were in the same order as the static strengths but showed less range. (author)

  1. Efecto de colutorio-gel de clorhexidina sobre el crecimiento de placa en 24 horas = Effect of chlorhexidine mouthrinses-gel on de novo plaque formation in 24 hours

    Directory of Open Access Journals (Sweden)

    Rivera, Tânia

    2006-01-01

    Full Text Available En un estudio cruzado, doble ciego y randomizado, 25 alumnos de Odontologia de buena salud oral, participaron de cuatro estudios donde ellos se abtuvieron de toda limpieza mecanica oral por 24 horas, los estudios estuvieron separados entre si por 4 semanas. Durante los estudios los alumnos en un randomizado orden, se enjuagaron por una vez con uno de los siguientes colutorios: CHX 0.12% + alcohol (Oralgene®, CHX 0.12% + alcohol (Perio.Aid®, CHX 0.1% + alcohol (Dentilim® y CHX 0.1% + HMC 2.5% (Colutoriogel®, nueva formula. Despues de un dia se midio formación de placa, se completo y registro el cuestionario de parametros clinicos. Las formulaciones de CHX 0.12% + alcohol y CHX 0.1% + HMC 2.5% se mostraron eficientes en retardar el crecimiento de placa dental de novo, esto obtenido de las observaciones clinicas, y siempre superior (p < 0.05 a la formulación del colutorio de CHX 0.1%+ alcohol (Dentilim®. Los resultados de este estudio demuestran el potencial clinico de este nuevo colutorio-gel sin alcohol de CHX 0.1% + HMC 2.5% (Colutoriogel® como un efectivo agente antiplaca y con reducidas efectos secundarios registrados

  2. Space charge sign inversion and electric field reconstruction in 24 GeV/c proton-irradiated MCZ Si p+-n(TD)-n+ detectors processed via thermal donor introduction

    International Nuclear Information System (INIS)

    Li, Z.; Verbitskaya, E.; Carini, G.; Chen, W.; Eremin, V.; Gul, R.; Haerkoenen, J.; Li, M.

    2009-01-01

    The aim of this study is the evaluation of radiation effects in detectors based on p-type magnetic czochralski (MCZ) Si that was converted to n-type by thermal donor (TD) introduction. As-processed p + -p-n + detectors were annealed at 430 deg. C resulting in p + -n(TD)-n + structures. The space charge sign and the electric field distribution E(x) in MCz Si p + -n(TD)-n + detectors irradiated by 24 GeV/c protons were analyzed using the data on the current pulse response and the Double Peak (DP) electric field distribution model for heavily irradiated detectors. The approach considers an irradiated detector as a structure with three regions in which the electric field depends on the coordinate, and the induced current pulse response arises from the drift process of free carriers in the detector with variable electric field. Reconstruction of the E(x) profile from the pulse response shapes is performed employing a new method for DP electric field reconstruction. This method includes: (a) a direct extraction of charge loss due to trapping and (b) the fitting of a simulated pulse response to the 'corrected' pulse by adjusting the electric field profiles in the three regions. Reconstruction of E(x) distribution showed that in the diodes irradiated by a proton fluence of (2-4)x10 14 p/cm 2 space charge sign inversion has occurred. This is the evidence that the influence of 24 GeV/c proton radiation on MCz Si p + -n(TD)-n + detectors is similar to that on p + -n-n + detectors based on FZ or diffusion oxygenated n-type Si.

  3. Effects of Diclofenac, L-NAME, L-Arginine, and Pentadecapeptide BPC 157 on Gastrointestinal, Liver, and Brain Lesions, Failed Anastomosis, and Intestinal Adaptation Deterioration in 24 Hour-Short-Bowel Rats.

    Science.gov (United States)

    Lojo, Nermin; Rasic, Zarko; Zenko Sever, Anita; Kolenc, Danijela; Vukusic, Darko; Drmic, Domagoj; Zoricic, Ivan; Sever, Marko; Seiwerth, Sven; Sikiric, Predrag

    2016-01-01

    Stable gastric pentadecapeptide BPC 157 was previously used to ameliorate wound healing following major surgery and counteract diclofenac toxicity. To resolve the increasing early risks following major massive small bowel resectioning surgery, diclofenac combined with nitric oxide (NO) system blockade was used, suggesting therapy with BPC 157 and the nitric oxide synthase (NOS substrate) L-arginine, is efficacious. Immediately after anastomosis creation, short-bowel rats were untreated or administered intraperitoneal diclofenac (12 mg/kg), BPC 157 (10 μg/kg or 10 ng/kg), L-NG-nitroarginine methyl ester (L-NAME, 5 mg/kg), L-arginine (100 mg/kg) alone or combined, and assessed 24 h later. Short-bowel rats exhibited poor anastomosis healing, failed intestine adaptation, and gastrointestinal, liver, and brain lesions, which worsened with diclofenac. This was gradually ameliorated by immediate therapy with BPC 157 and L-arginine. Contrastingly, NOS-blocker L-NAME induced further aggravation and lesions gradually worsened. Specifically, rats with surgery alone exhibited mild stomach/duodenum lesions, considerable liver lesions, and severe cerebral/hippocampal lesions while those also administered diclofenac showed widespread severe lesions in the gastrointestinal tract, liver, cerebellar nuclear/Purkinje cells, and cerebrum/hippocampus. Rats subjected to surgery, diclofenac, and L-NAME exhibited the mentioned lesions, worsening anastomosis, and macro/microscopical necrosis. Thus, rats subjected to surgery alone showed evidence of deterioration. Furtheremore, rats subjected to surgery and administered diclofenac showed worse symptoms, than the rats subjected to surgery alone did. Rats subjected to surgery combined with diclofenac and L-NAME showed the worst deterioration. Rats subjected to surgery exhibited habitual adaptation of the remaining small intestine, which was markedly reversed in rats subjected to surgery and diclofenac, and those with surgery, diclofenac, and L-NAME. BPC 157 completely ameliorated symptoms in massive intestinal resection-, massive intestinal resection plus diclofenac-, and massive intestinal resection plus diclofenac plus L-NAME-treated short bowel rats that presented with cyclooxygenase (COX)-NO-system inhibition. L-arginine ameliorated only L-NAME-induced aggravation of symptoms in rats subjected to massive intestinal resection and administered diclofenac plus L-NAME.

  4. Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803

    Directory of Open Access Journals (Sweden)

    Pistorius Elfriede K

    2007-11-01

    Full Text Available Abstract Background So far very limited knowledge exists on L-arginine catabolism in cyanobacteria, although six major L-arginine-degrading pathways have been described for prokaryotes. Thus, we have performed a bioinformatic analysis of possible L-arginine-degrading pathways in cyanobacteria. Further, we chose Synechocystis sp. PCC 6803 for a more detailed bioinformatic analysis and for validation of the bioinformatic predictions on L-arginine catabolism with a transcript analysis. Results We have evaluated 24 cyanobacterial genomes of freshwater or marine strains for the presence of putative L-arginine-degrading enzymes. We identified an L-arginine decarboxylase pathway in all 24 strains. In addition, cyanobacteria have one or two further pathways representing either an arginase pathway or L-arginine deiminase pathway or an L-arginine oxidase/dehydrogenase pathway. An L-arginine amidinotransferase pathway as a major L-arginine-degrading pathway is not likely but can not be entirely excluded. A rather unusual finding was that the cyanobacterial L-arginine deiminases are substantially larger than the enzymes in non-photosynthetic bacteria and that they are membrane-bound. A more detailed bioinformatic analysis of Synechocystis sp. PCC 6803 revealed that three different L-arginine-degrading pathways may in principle be functional in this cyanobacterium. These are (i an L-arginine decarboxylase pathway, (ii an L-arginine deiminase pathway, and (iii an L-arginine oxidase/dehydrogenase pathway. A transcript analysis of cells grown either with nitrate or L-arginine as sole N-source and with an illumination of 50 μmol photons m-2 s-1 showed that the transcripts for the first enzyme(s of all three pathways were present, but that the transcript levels for the L-arginine deiminase and the L-arginine oxidase/dehydrogenase were substantially higher than that of the three isoenzymes of L-arginine decarboxylase. Conclusion The evaluation of 24 cyanobacterial genomes revealed that five different L-arginine-degrading pathways are present in the investigated cyanobacterial species. In Synechocystis sp. PCC 6803 an L-arginine deiminase pathway and an L-arginine oxidase/dehydrogenase pathway represent the major pathways, while the L-arginine decarboxylase pathway most likely only functions in polyamine biosynthesis. The transcripts encoding the enzymes of the two major pathways were constitutively expressed with the exception of the transcript for the carbamate kinase, which was substantially up-regulated in cells grown with L-arginine.

  5. Administration and Management of Irrigation Water in 24 User Organizations in Chile Administración y Gestión del Agua de Riego en 24 Organizaciones de Usuarios en Chile

    Directory of Open Access Journals (Sweden)

    Jara Jorge

    2009-06-01

    Full Text Available Approximately 85% of the water consumed in Chile is destined to agricultural irrigation and is managed by the users themselves. This study analyzed the price that irrigation water users pay to their Water User Associations (WUAs to which they belong and the relationship of this price to the professional level and performance of the WUAs. The study included 24 WUAs: 10 River Administration Boards (JV and 14 Irrigation Canal Associations (AC. The annual operational budget of each WUA, the price paid by users and the management capacities of the board of directors of each WUA were compared. The study also determined the relative value of user payments to WUAs as a proportion of total production costs of the main crops in each zone. The variability of user fees per irrigated hectare decreases when the irrigation area of the WUA is more than 10 000 ha, though this was not observed in JVs. The presence of technical-professional staff directly affects the development and growth of the WUAs. As well, the WUAs with a greater level of capacity development (NDC have more board members with a higher education level and have lower rates of unpaid user fees. The price that users pay to the WUA by irrigated hectare represents less than 4.0% of the average total production cost of the main crops in the study area. Finally, no correlation was found between the prices that users pay and the average profitability of the main crops, or between price and the geographical location of the WUAs.Aproximadamente, el 85% del agua consumida en Chile es destinada al riego agrícola, siendo administrada por los propios usuarios. En este estudio, se analizó el costo que cancelan los usuarios del agua de riego a sus Organizaciones de Usuarios de Agua (WUAs y el nivel de profesionalización y desempeño de éstas. Se estudiaron 24 WUAs: 10 Juntas de Vigilancia (JV y 14 Asociaciones de Canalistas (AC. Se comparó el presupuesto anual de operaciones de cada WUA, el valor que cancelan los usuarios y las capacidades de gestión de la directiva con el desempeño de la respectiva WUA. Además, se analizó la significancia del pago de los usuarios en los costos de producción de los principales cultivos en cada zona. En las AC, la variabilidad de precios por hectárea regada que cancelan los usuarios, disminuye cuando el territorio de la WUA es mayor a 10 000 ha, situación no detectada en las JV. El personal técnico-profesional de apoyo incide directamente sobre el desarrollo y crecimiento de las WUAs. Asimismo, las WUAs con nivel de desarrollo de capacidades (NDC más elevado poseen directivas con mayor escolaridad promedio y los usuarios presentan menor morosidad en el pago. El precio que cancelan los usuarios a las WUAs por hectárea regada representa menos del 4,0% de los costos promedio totales de producción de los principales cultivos de cada zona. Finalmente, no se evidenció correlación entre el precio que cancelan los usuarios y la rentabilidad promedio de los cultivos, ni por ubicación geográfica de las WUAs.

  6. Oxytocin may be useful to increase trust in others and decrease disruptive behaviours in patients with Prader-Willi syndrome: a randomised placebo-controlled trial in 24 patients

    Directory of Open Access Journals (Sweden)

    Ehlinger Virginie

    2011-06-01

    Full Text Available Abstract Background Prader-Willi syndrome (PWS is a complex neurodevelopmental genetic disorder with hypothalamic dysfunction, early morbid obesity with hyperphagia, and specific psychiatric phenotypes including cognitive and behavioural problems, particularly disruptive behaviours and frequent temper outbursts that preclude socialization. A deficit in oxytocin (OT-producing neurons of the hypothalamic paraventricular nucleus has been reported in these patients. Methods In a double-blind, randomised, placebo-controlled study, 24 adult patients with PWS received a single intranasal administration of 24 IU of OT or placebo and were tested 45 min later on social skills. Behaviours were carefully monitored and scored using an in-house grid as follows: over the two days before drug administration, on the half-day following administration, and over the subsequent two days. All patients were in a dedicated PWS centre with more than ten years of experience. Patients are regularly admitted to this controlled environment. Results Patients with PWS who received a single intranasal administration of OT displayed significantly increased trust in others (P = 0.02 and decreased sadness tendencies (P = 0.02 with less disruptive behaviour (P = 0.03 in the two days following administration than did patients who received placebo. In the half-day following administration, we observed a trend towards less conflict with others (p = 0.07 in the OT group compared with the placebo group. Scores in tests assessing social skills were not significantly different between the two groups. Conclusions This study needs to be reproduced and adapted. It nevertheless opens new perspectives for patients with PWS and perhaps other syndromes with behavioural disturbances and obesity. Trial registration number ClinicalTrials.gov: NCT01038570

  7. This time it’s different? Effects of the Eurovision Debate on young citizens and its consequence for EU democracy–evidence from a quasi-experiment in 24 countries

    DEFF Research Database (Denmark)

    Maier, Jürgen; Faas, Thorsten; Rittberger, Berthold

    2018-01-01

    For the very first time in EU history, the 2014 EP elections provided citizens with the opportunity to influence the nomination of the Commission President by casting a vote for the main Europarties’ ‘lead candidates’. By subjecting the position of the Commission President to an open political...... contest, many experts have formulated the expectation that heightened political competition would strengthen the weak electoral connection between EU citizens and EU legislators, which some consider a root cause for the EU’s lack of public support. In particular, this contest was on display in the so...... citizens. Unfortunately, the debate has only reached a very small audience....

  8. Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803

    OpenAIRE

    Schriek, Sarah; R?ckert, Christian; Staiger, Dorothee; Pistorius, Elfriede K; Michel, Klaus-Peter

    2007-01-01

    Abstract Background So far very limited knowledge exists on L-arginine catabolism in cyanobacteria, although six major L-arginine-degrading pathways have been described for prokaryotes. Thus, we have performed a bioinformatic analysis of possible L-arginine-degrading pathways in cyanobacteria. Further, we chose Synechocystis sp. PCC 6803 for a more detailed bioinformatic analysis and for validation of the bioinformatic predictions on L-arginine catabolism with a transcript analysis. Results W...

  9. The rate of calcium extraction during EDTA decalcification from thin bone slices as assessed with atomic absorption spectrophotometry.

    Science.gov (United States)

    Kiviranta, I; Tammi, M; Lappalainen, R; Kuusela, T; Helminen, H J

    1980-01-01

    The rate of calcium extraction with EDTA (ethylenediamine tetraacetic acid) from thin bone slices (300 micrometer-3 mm thick) was determined by aid of an atomic absorption spectrophotometer. A 0.5 mm thick bone slice was completely decalcified with 15% (0.40 M), 8% (0.22 M), and 4% (0.11 M) EDTA in 24 h, 3 days, and 5 days, respectively (vol. 15 ml, temp. 4 degrees C, pH 7.4). At 37 and 60 degrees C the speed of demineralization was slightly increased as compared with that at 20 degrees C, while no difference was observed between 4 and 20 degrees C. Bone slices with a thickness of 0.3, 0.5, 1 and 2 mm were decalcified -- in the same order -- in 24 h, 2, 3, and 5 days (8% EDTA, 4 degrees C, pH 7.4). At pH 7.4, the decalcification rate was a little slower than at pH 5.0 and 8.5. Agitation did not affect the decalcifying velocity, nor did the volume of the agent, except when the volume was very small. The demineralization of ordinary bone, containing both compact and spongy bone, was found to be more rapid than that of homogeneous bone reported earlier. The acidic buffers and New Decalc, which served as reference substances, exerted a more vigorous decalcifying effect thatn EDTA. K formate/formic acid buffer, pH 3.15, demineralized a 1 mm thick bone slice in 24 h and 2 days was needed with Na lactate/lactic acid buffer, pH 3.70. With New Decalc, pH 0.9, the corresponding demineralization was accomplished in 1.5 h. Atomic absorption spectrophotometer proved to be a useful tool in the evaluation of calcium extraction velocity from bone slices.

  10. Bacterial consortia constructed for the decomposition of Agave biomass.

    Science.gov (United States)

    Maki, Miranda; Iskhakova, Svetlana; Zhang, Tingzhou; Qin, Wensheng

    2014-01-01

    Research has shown that a greater variety of enzymes, as well as variety of microorganisms producing enzymes, can have an overall synergistic effect on the decomposition of lignocellulosic biomass for the production of value-added bio-products. Here, 8 cellulase-degrading bacterial isolates were selected to develop co-, tri-, and tetra-cultures for the decomposition of lignocellulosic biomass. Glucose and xylose equivalents released from imitation biomass media containing 0.5% (w/v) beechwood xylan and 0.5% (w/v) Avicel was measured using di-nitrosalicylic acid for all consortia, along with cell growth and survival. Thereafter, 6 co- and 2 tri-cultures with greatest decomposition were examined for ability to degrade Agave americana fiber. Interestingly, when strains were paired up in co-culture, four pairs: G+5, G+A, C+A1, and G+A1 produced high reducing sugars in 24 h: 6 µM, 8 µM, 8 µM, and finally, 6 µM, respectively. From 4 co-cultures with highest reducing sugar equivalents, tri- and tetra-cultures were produced. The bacterial consortia which had the highest reducing sugars detected were 2 tri-cultures: G + A1 + A4 and G + A1 + 5, displaying levels as high as 9 µM and 5 µM in day 1, respectively. All co- and tri-cultures maintained high cell survival for 14 days with 0.5 g ground Agave. Upon evaluating Agave dry weight after treatment, it was evident that almost half the biomass could be decomposed in 14 days. Scanning electron microscopy of treated Agave supported decomposition when compared with the control. These bacterial consortia have potential for further study of value-added by-product production during metabolism of lignocellulosic biomasses.

  11. Missing dosages and neuroleptic usage may prolong length of stay in hospitalized Parkinson's disease patients.

    Directory of Open Access Journals (Sweden)

    Daniel Martinez-Ramirez

    Full Text Available Parkinson's disease patients are more likely to be hospitalized, have higher rates of hospital complications, and have an increased risk of deterioration during hospitalization. Length of stay is an important underlying factor for these increased risks. We aimed to investigate potential medication errors that may occur during hospitalization and its impact on length of hospital stay.A cross-sectional chart review of 339 consecutive hospital encounters from 212 PD subjects was performed. Medication errors were defined as wrong timing or omission of administration for dopaminergic drugs and administration of contraindicated dopamine blockers. An analysis of covariance was applied to examine whether these medication errors were related to increased length of hospital stays.A significant effect for dopaminergic administration (p<0.01 on length of hospital stay was observed. Subjects who had delayed administration or missed at least one dose stayed longer (M=8.2 days, SD=8.9 vs. M=3.6 days SD=3.4. Contraindicated dopamine blocking agents were administered in 23% (71/339 of cases, and this was also significantly related to an increased length of stay (M=8.2 days, SD=8.9 vs. M=3.6 days SD=3.4, p<0.05. Participants who received a contraindicated dopamine blocker stayed in the hospital longer (M=7.5 days, SD=9.1 compared to those who did not (M=5.9 days, SD=6.8. Neurologists were consulted in 24.5% of encounters. Specialty consultation had no effect on the medication related errors.Missing dopaminergic dosages and administration of dopamine blockers occur frequently in hospitalized Parkinson's disease patients and this may impact length of stay. These potentially modifiable factors may reduce the risk of a longer stay related to hospitalization.

  12. Hepatitis C: sexual or intrafamilial transmission? Epidemiological and phylogenetic analysis of hepatitis C virus in 24 infected couples Hepatite C: transmissão sexual ou intrafamiliar? Análise epidemiológica e filogenética do vírus da hepatite C em 24 casais infectados

    Directory of Open Access Journals (Sweden)

    Norma de Paula Cavalheiro

    2009-06-01

    Full Text Available The role of sexual or intrafamilial transmission of hepatitis C is controversial. A phylogenetic analysis was performed on the non-structural region 5B of the hepatitis C virus (NS5B-HCV. High percentages of homology (mean of 98.3% were shown between the couples. Twenty (83.3% of the 24 men but only two of the women (8.3% reported having had sexually transmitted diseases during their lives. The risk factors for HCV acquisition were blood transfusion (10 couples, use of illegal injected drugs (17, use of inhalants (15, acupuncture (5 and tattoos (5. The shared use of personal hygiene items included toothbrushes between six couples (25%, razor blades between 16 (66.7%, nail clippers between 21 (87.5% and manicure pliers between 14 (58.3%. The high degree of similarity of the hepatitis C virus genome supports the hypothesis of hepatitis C virus transmission between these couples. The shared use of personal hygiene items suggests the possibility of intrafamilial transmission of infection.O papel da transmissão sexual ou intrafamiliar da hepatite C é controverso. Foi feita análise filogenética, região não estrutural 5B do vírus da hepatite C (NS5B-HCV. Altas percentagens de homologia com média de 98,3% foi revelada entre os casais. Vinte (83,3% de 24 homens, contra apenas duas (8,3% mulheres reportaram doença sexualmente transmisível durante suas vidas. Os fatores de risco para aquisição da doença foram: transfusão de sangue para 10 casais, uso de drogas ilícitas injetáveis para 17, inalatórias para 15, acupuntura em 5 e tatuagens para 5. O compartilhamento de utensílios de higiene pessoal incluem: escova de dente para seis (25% dos casais, lâmina de barbear para 16 (66,7%, cortador de unhas para 21 (87,5% e alicate de manicure para 14 (58,3%. O alto grau de similaridade genômica entre os vírus da hepatite C suporta a hipótese de transmissão entre os casais. O uso compartilhado de utensílios de higiene pessoal sugere a possibilidade de transmissão intrafamiliar.

  13. Clinical characteristics and evolution of syphilis in 24 HIV+ individuals in Rio de Janeiro, Brazil Características clínicas e evolutivas da sífilis em 24 indivíduos HIV+ no Rio de Janeiro, Brasil

    Directory of Open Access Journals (Sweden)

    Maria Clara Gutierrez-Galhardo

    2005-06-01

    Full Text Available A total of 24 patients with syphilis and HIV infection were treated from January 1997 to March 2003 at the Infectious Dermatology Outpatient Clinic of the Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. The caseload consisted of 20 males (83.3% and four females (16.7%, with a mean age of 38.04 years and mean T CD4+ count of 389.5 cells/mL. Syphilis was diagnosed as secondary in 16 (62.5% patients, late latent in eight (33.3%, and tertiary in one (4.2%. Manifestations of secondary syphilis were palmar and plantar erythematopapulous cutaneous lesions in nine (37.5%, papulous exanthema in four (16.7%, patchy alopecia in 3 (12.5% and osteochondritis in one patient (4.2%. Tertiary syphilis was characterized by verrucous lesions. Neurosyphilis was diagnosed in four patients (16.7%, with headache as the only manifestation in two patients. Drugs used in treatment included benzathine penicillin, ceftriaxone, erythromycin, and crystalline penicillin. Cure was achieved in 18 patients (75%. Five patients (20.8% were retreated, three of whom presented a history of re-exposure. This study confirms the importance of establishing the diagnosis of neurosyphilis in patients with HIV infection, in addition to performing follow-up on treatment for syphilis.Foram tratados 24 indivíduos com sífilis e infecção pelo HIV, de Março de 1997 a Janeiro de 2003, no ambulatório de Dermatologia Infecciosa do Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil. Foram 20 homens (83,3% e quatro mulheres (16,7% com idade média de 38,04 anos e contagem média de linfócitos T CD4 de 389,5 céls/mm³. A sífilis foi classificada como secundária em 16 pacientes (62,5%, latente tardia em oito (33,3% e terciária em uma paciente (4,2%. As manifestações de sífilis secundária foram de lesões cutâneas eritematopapulosas em regiões palmar e plantar em nove (37,5%, exantema papuloso em quatro (16,7%, alopecia em clareira em três (12,5% e osteocondrite em um paciente (4,2%. A sífilis terciária apresentou-se como lesão verrucosa. Cinco pacientes (20,8% apresentavam neurossífilis, sendo a cefaléia a única manifestação presente em dois pacientes. As drogas utilizadas foram penicilina benzatina, ceftriaxone, eritromicina e penicilina. A cura ocorreu em 18 pacientes (75%. Seis pacientes (25% foram retratados, sendo que três apresentavam história de re-exposição. Este estudo confirmou a importância de se estabelecer o diagnóstico de neurossífilis em pacientes com infecção pelo HIV, assim como de se realizar seguimento clínico e laboratorial após o tratamento da sífilis.

  14. Protocolo de actuación preventiva para riesgo debido a alteraciones del ritmo circadiano en médicos de urgencias que trabajan en turnos de 24 horas Preventive action protocol for risk due to circadian rhythm disturbances in emergency physicians working in 24 hours shifts

    Directory of Open Access Journals (Sweden)

    Loreto Fillat de Acosta

    2009-12-01

    Full Text Available La autora analiza la situación patológica de los médicos de urgencias con turnos de 24 horas que alteran el ritmo circadiano, el estudio describe las condiciones de trabajo que afectan el ritmo biológico sueño-vigilia y las tareas intelectuales y de habilidades mecánicas desempeñadas por este personal, los daños a prevenir (accidentes in itinere, accidentes por manipulación de material biológico, enfermedades somáticas y psíquicas y el riesgo para los pacientes. Se propone un protocolo de actuación preventiva que abarca la mayor parte del trabajo, cuándo actuar, revisión de recursos, actuaciones a realizar en una unidad de salud laboral y sistema de comunicación al resto del hospital, Servicio de Prevención de Riesgos Laborales y Sistema Nacional de Salud.The author analyzes the pathological situation concerning to emergency physicians with 24-hour shifts which disturb their circadian rhythms, the study describes the working conditions that affect the biological sleep-wake rhythm and intellectual tasks and mechanical skills performed by these staff, damage to be prevented (commuting accidents, accidents caused by handling of biological material, somatic and psychic diseases and the risk to patients. After that, it's developed a proposal of preventive action protocol covering most of the work and finally when to act, available resources and actions to be taken in an occupational health unit, in addition to the communication system to the rest of the hospital, Occupational and Hazard Preventive Service and the National Health System.

  15. Contribuição ao conhecimento da ictiofauna do Manguezal de Cacha Pregos, Ilha de Itaparica, Baía de Todos os Santos, Bahia Contribution to knowledge of ichthyofauna of Mangrove Cacha Pregos, Itaparica island, Todos os Santos bay, Bahia

    Directory of Open Access Journals (Sweden)

    Paulo Roberto Duarte Lopes

    1998-01-01

    Full Text Available A check-list of fishes collected in a mangrove in Cacha Pregos, south of ltaparic Island, State of Bahia, Brazil (about 13o07'S,38o48'W from 1988-1989 and 1991-1992 is presented. Fifteen orders, 46 families and 85 species (Teleostei except one Chondrichthyes were identified, represented specimens whose adults live in different marine ecossystems.

  16. The role of calcium, calcium-activated K+ channels, and tyrosine/kinase in psoralen-evoked responses in human melanoma cells

    Directory of Open Access Journals (Sweden)

    Isoldi M.C.

    2004-01-01

    Full Text Available 8-Methoxy psoralen (8-MOP exerts a short-term (24 h mitogenic action, and a long-term (48-72 h anti-proliferative and melanogenic action on two human melanoma cell lines, SK-Mel 28 and C32TG. An increase of intracellular calcium concentration was observed by spectrofluorometry immediately after the addition of 0.1 mM 8-MOP to both cell lines, previously incubated with calcium probe fluo-3 AM (5 µM. The intracellular Ca2+ chelator BAPTA/AM (1 µM blocked both early (mitogenic and late (anti-proliferative and melanogenic 8-MOP effects on both cell lines, thus revealing the importance of the calcium signal in both short- and long-term 8-MOP-evoked responses. Long-term biological assays with 5 and 10 mM tetraethylammonium chloride (TEA, an inhibitor of Ca2+-dependent K+ channels did not affect the responses to psoralen; however, in 24-h assays 10 mM TEA blocked the proliferative peak, indicating a modulation of Ca2+-dependent K+ channels by 8-MOP. No alteration of cAMP basal levels or forskolin-stimulated cAMP levels was promoted by 8-MOP in SK-Mel 28 cells, as determined by radioimmunoassay. However, in C32TG cells forskolin-stimulated cAMP levels were further increased in the presence of 8-MOP. In addition, assays with 1 µM protein kinase C and calcium/calmodulin-dependent kinase inhibitors, Ro 31-8220 and KN-93, respectively, excluded the participation of these kinases in the responses evoked by 8-MOP. Western blot with antibodies anti-phosphotyrosine indicated a 92% increase of the phosphorylated state of a 43-kDa band, suggesting that the phosphorylation of this protein is a component of the cascade that leads to the increase of tyrosinase activity.

  17. Memory Abilities in Children with Mathematical Difficulties: Comorbid Language Difficulties Matter

    Science.gov (United States)

    Reimann, Giselle; Gut, Janine; Frischknecht, Marie-Claire; Grob, Alexander

    2013-01-01

    The present study investigated cognitive abilities in children with difficulties in mathematics only (n = 48, M = 8 years and 5 months), combined mathematical and language difficulty (n = 27, M = 8 years and 1 month) and controls (n = 783, M = 7 years and 11 months). Cognitive abilities were measured with seven subtests, tapping visual perception,…

  18. 77 FR 76597 - Petition for Waiver of Compliance

    Science.gov (United States)

    2012-12-28

    ... also requesting to exclude test requirements for all the air brake valves in the KB-CT1a (M8) System... maintenance interval for the MNR MU M8 Air Brake System (KB-CT1a) and to include by amendment this 405-unit... periodic brake maintenance for multiple unit (MU) locomotives and the special approval procedure under 49...

  19. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.

    Science.gov (United States)

    Almeida, M Camila; Hew-Butler, Tamara; Soriano, Renato N; Rao, Sara; Wang, Weiya; Wang, Judy; Tamayo, Nuria; Oliveira, Daniela L; Nucci, Tatiane B; Aryal, Prafulla; Garami, Andras; Bautista, Diana; Gavva, Narender R; Romanovsky, Andrej A

    2012-02-08

    We studied N-(2-aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride (M8-B), a selective and potent antagonist of the transient receptor potential melastatin-8 (TRPM8) channel. In vitro, M8-B blocked cold-induced and TRPM8-agonist-induced activation of rat, human, and murine TRPM8 channels, including those on primary sensory neurons. In vivo, M8-B decreased deep body temperature (T(b)) in Trpm8(+/+) mice and rats, but not in Trpm8(-/-) mice, thus suggesting an on-target action. Intravenous administration of M8-B was more effective in decreasing T(b) in rats than intrathecal or intracerebroventricular administration, indicating a peripheral action. M8-B attenuated cold-induced c-Fos expression in the lateral parabrachial nucleus, thus indicating a site of action within the cutaneous cooling neural pathway to thermoeffectors, presumably on sensory neurons. A low intravenous dose of M8-B did not affect T(b) at either a constantly high or a constantly low ambient temperature (T(a)), but the same dose readily decreased T(b) if rats were kept at a high T(a) during the M8-B infusion and transferred to a low T(a) immediately thereafter. These data suggest that both a successful delivery of M8-B to the skin (high cutaneous perfusion) and the activation of cutaneous TRPM8 channels (by cold) are required for the hypothermic action of M8-B. At tail-skin temperatures cold) activation of TRPM8. M8-B affected all thermoeffectors studied (thermopreferendum, tail-skin vasoconstriction, and brown fat thermogenesis), thus suggesting that TRPM8 is a universal cold receptor in the thermoregulation system.

  20. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature

    Science.gov (United States)

    Almeida, M. Camila; Hew-Butler, Tamara; Soriano, Renato N.; Rao, Sara; Wang, Weiya; Wang, Judy; Tamayo, Nuria; Oliveira, Daniela L.; Nucci, Tatiane B.; Aryal, Prafulla; Garami, Andras; Bautista, Diana; Gavva, Narender R.; Romanovsky, Andrej A.

    2012-01-01

    We studied M8-B, a selective and potent antagonist of the transient receptor potential melastatin-8 (TRPM8) channel. In vitro, M8-B blocked cold-induced and TRPM8-agonist-induced activation of rat, human, and murine TRPM8 channels, including those on primary sensory neurons. In vivo, M8-B decreased deep body temperature (Tb) in Trpm8+/+ mice and rats, but not in Trpm8−/− mice, thus suggesting an on-target action. The intravenous administration of M8-B was more effective in decreasing Tb in rats than the intrathecal or intracerebroventricular administration, indicating a peripheral action. M8-B attenuated cold-induced c-Fos expression in the lateral parabrachial nucleus, thus indicating a site of action within the cutaneous cooling neural pathway to thermoeffectors, presumably on sensory neurons. A low intravenous dose of M8-B did not affect Tb at either a constantly high or a constantly low ambient temperature (Ta), but the same dose readily decreased Tb if rats were kept at a high Ta during the M8-B infusion and transferred to a low Ta immediately thereafter. These data suggest that both a successful delivery of M8-B to the skin (high cutaneous perfusion) and the activation of cutaneous TRPM8 channels (by cold) are required for the hypothermic action of M8-B. At tail skin temperatures cold) activation of TRPM8. M8-B affected all thermoeffectors studied (thermopreferendum, tail skin vasoconstriction, and brown fat thermogenesis), thus suggesting that TRPM8 is a universal cold receptor in the thermoregulation system. PMID:22323721

  1. Testing earthquake prediction algorithms: Statistically significant advance prediction of the largest earthquakes in the Circum-Pacific, 1992-1997

    Science.gov (United States)

    Kossobokov, V.G.; Romashkova, L.L.; Keilis-Borok, V. I.; Healy, J.H.

    1999-01-01

    Algorithms M8 and MSc (i.e., the Mendocino Scenario) were used in a real-time intermediate-term research prediction of the strongest earthquakes in the Circum-Pacific seismic belt. Predictions are made by M8 first. Then, the areas of alarm are reduced by MSc at the cost that some earthquakes are missed in the second approximation of prediction. In 1992-1997, five earthquakes of magnitude 8 and above occurred in the test area: all of them were predicted by M8 and MSc identified correctly the locations of four of them. The space-time volume of the alarms is 36% and 18%, correspondingly, when estimated with a normalized product measure of empirical distribution of epicenters and uniform time. The statistical significance of the achieved results is beyond 99% both for M8 and MSc. For magnitude 7.5 + , 10 out of 19 earthquakes were predicted by M8 in 40% and five were predicted by M8-MSc in 13% of the total volume considered. This implies a significance level of 81% for M8 and 92% for M8-MSc. The lower significance levels might result from a global change in seismic regime in 1993-1996, when the rate of the largest events has doubled and all of them become exclusively normal or reversed faults. The predictions are fully reproducible; the algorithms M8 and MSc in complete formal definitions were published before we started our experiment [Keilis-Borok, V.I., Kossobokov, V.G., 1990. Premonitory activation of seismic flow: Algorithm M8, Phys. Earth and Planet. Inter. 61, 73-83; Kossobokov, V.G., Keilis-Borok, V.I., Smith, S.W., 1990. Localization of intermediate-term earthquake prediction, J. Geophys. Res., 95, 19763-19772; Healy, J.H., Kossobokov, V.G., Dewey, J.W., 1992. A test to evaluate the earthquake prediction algorithm, M8. U.S. Geol. Surv. OFR 92-401]. M8 is available from the IASPEI Software Library [Healy, J.H., Keilis-Borok, V.I., Lee, W.H.K. (Eds.), 1997. Algorithms for Earthquake Statistics and Prediction, Vol. 6. IASPEI Software Library]. ?? 1999 Elsevier

  2. Pulsed laser deposition of epitaxial Sr(RuxSn1-x)O3 thin film electrodes and KNbO3/Sr(RuxSn1-x)O3 bilayers

    International Nuclear Information System (INIS)

    Christen, H.M.; Boatner, L.A.; English, L.Q.; Geea, L.A.; Marrero, P.J.; Norton, D.P.

    1995-01-01

    Sr(Ru x Sn 1-x ) 3 is proposed as a new conducting oxide for use in epitaxial multilayer structures. The Sr(Ru o 48 Sn 0.52 )0 3 composition exhibits an excellent lattice match with (100)-oriented KTaO 3 , and films of this composition grown by pulsed laser deposition on KTaO 3 , SrTiO 3 , and LaAlO 3 substrates have been analyzed by X-ray diffraction, Rutherford backscattering/ion channeling, and resistivity measurements. Epitaxial KNbO 3 /Sr(Ru 0.48 Sn 0.52 )O 3 bilayers have been successfully grown

  3. Discontinuous haulage and disposal of moist ash from the Gacko power plant at the Drazljevo dump site

    Energy Technology Data Exchange (ETDEWEB)

    Grbovic, M.; Knezevic, D.; Todorovic, D. (Rudarski Institut, Belgrade (Yugoslavia))

    1990-01-01

    Describes the ash disposal technology of the Gacko lignite fired power plant in Yugoslavia. The ash has a high content of chemically active CaO (48.9%), a pH value of 12 and shows high exothermal reactions on contact with water. Ash lime slaking before disposal at the dumping site is therefore required. The ash slaking technology consists of ash transport from the power plant by container trucks to an ash conditioning installation (ash agitation with water) and hydraulic pipe transport of the ash slurry to the Drazljevo dumping site. 7 refs.

  4. Dicty_cDB: VHO576 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available mal sarcosine oxidase; S... 48 1e-04 BC114006_1( BC114006 |pid:none) Bos taurus L-pipecolic acid oxidas... 4...8 1e-04 BC088249_1( BC088249 |pid:none) Rattus norvegicus pipecolic acid o... 48 2e-04 AY892312_1( AY892312 ...id:none) Pongo abelii mRNA; cDNA DKFZp469L1... 48 2e-04 BC027622_1( BC027622 |pid:none) Homo sapiens pipecoli

  5. 76 FR 77268 - National Science Board; Sunshine Act Meetings; Notice Revised

    Science.gov (United States)

    2011-12-12

    ... & Discussion: NSF High Performance Computing Strategy NSB Briefing: Update on Changes in BIO Process in Receipt... 8 a.m.-8:20 a.m. Chairman's Introduction CPP Task Force on Unsolicited Mid-Scale Research (MS) Open...

  6. 76 FR 76769 - National Science Board; Sunshine Act Meetings

    Science.gov (United States)

    2011-12-08

    ... & Discussion: NSF High Performance Computing Strategy. NSB Briefing: Update on Changes in BIO Process in... 8:00 a.m.-8:20 a.m. Chairman's Introduction CPP Task Force on Unsolicited Mid-Scale Research (MS...

  7. Combined Cytolytic Effects of a Vaccinia Virus Encoding a Single Chain Trimer of MHC-I with a Tax-Epitope and Tax-Specific CTLs on HTLV-I-Infected Cells in a Rat Model

    Directory of Open Access Journals (Sweden)

    Takashi Ohashi

    2014-01-01

    Full Text Available Adult T cell leukemia (ATL is a malignant lymphoproliferative disease caused by human T cell leukemia virus type I (HTLV-I. To develop an effective therapy against the disease, we have examined the oncolytic ability of an attenuated vaccinia virus (VV, LC16m8Δ (m8Δ, and an HTLV-I Tax-specific cytotoxic T lymphocyte (CTL line, 4O1/C8, against an HTLV-I-infected rat T cell line, FPM1. Our results demonstrated that m8Δ was able to replicate in and lyse tumorigenic FPM1 cells but was incompetent to injure 4O1/C8 cells, suggesting the preferential cytolytic activity toward tumor cells. To further enhance the cytolysis of HTLV-I-infected cells, we modified m8Δ and obtained m8Δ/RT1AlSCTax180L, which can express a single chain trimer (SCT of rat major histocompatibility complex class I with a Tax-epitope. Combined treatment with m8Δ/RT1AlSCTax180L and 4O1/C8 increased the cytolysis of FPM1V.EFGFP/8R cells, a CTL-resistant subclone of FPM1, compared with that using 4O1/C8 and m8Δ presenting an unrelated peptide, suggesting that the activation of 4O1/C8 by m8Δ/RT1AlSCTax180L further enhanced the killing of the tumorigenic HTLV-I-infected cells. Our results indicate that combined therapy of oncolytic VVs with SCTs and HTLV-I-specific CTLs may be effective for eradication of HTLV-I-infected cells, which evade from CTL lysis and potentially develop ATL.

  8. Behavioral and Socio-Emotional Functioning in Children with Selective Mutism: A Comparison with Anxious and Typically Developing Children across Multiple Informants

    Science.gov (United States)

    Carbone, Diana; Schmidt, Louis A.; Cunningham, Charles C.; McHolm, Angela E.; Edison, Shannon; St. Pierre, Jeff; Boyle, Michael H.

    2010-01-01

    We examined differences among 158 children, 44 with selective mutism (SM; M = 8.2 years, SD = 3.4 years), 65 with mixed anxiety (MA; M = 8.9 years, SD = 3.2 years), and 49 community controls (M = 7.7 years, SD = 2.6 years) on primary caregiver, teacher, and child reports of behavioral and socio-emotional functioning. Children with SM were rated…

  9. Elicitation of Both Anti HIV-1 Env Humoral and Cellular Immunities by Replicating Vaccinia Prime Sendai Virus Boost Regimen and Boosting by CD40Lm

    Science.gov (United States)

    Zhang, Xianfeng; Sobue, Tomoyoshi; Isshiki, Mao; Makino, Shun-ichi; Inoue, Makoto; Kato, Kazunori; Shioda, Tatsuo; Ohashi, Takashi; Sato, Hirotaka; Komano, Jun; Hanabusa, Hideji; Shida, Hisatoshi

    2012-01-01

    For protection from HIV-1 infection, a vaccine should elicit both humoral and cell-mediated immune responses. A novel vaccine regimen and adjuvant that induce high levels of HIV-1 Env-specific T cell and antibody (Ab) responses was developed in this study. The prime-boost regimen that used combinations of replication-competent vaccinia LC16m8Δ (m8Δ) and Sendai virus (SeV) vectors expressing HIV-1 Env efficiently produced both Env-specific CD8+ T cells and anti-Env antibodies, including neutralizing antibodies (nAbs). These results sharply contrast with vaccine regimens that prime with an Env expressing plasmid and boost with the m8Δ or SeV vector that mainly elicited cellular immunities. Moreover, co-priming with combinations of m8Δs expressing Env or a membrane-bound human CD40 ligand mutant (CD40Lm) enhanced Env-specific CD8+ T cell production, but not anti-Env antibody production. In contrast, priming with an m8Δ that coexpresses CD40Lm and Env elicited more anti-Env Abs with higher avidity, but did not promote T cell responses. These results suggest that the m8Δ prime/SeV boost regimen in conjunction with CD40Lm expression could be used as an immunization platform for driving both potent cellular and humoral immunities against pathogens such as HIV-1. PMID:23236521

  10. The molecule HLA-G: radiosensitivity indicator of a human melanoma cell line

    International Nuclear Information System (INIS)

    Michelin, S.C.; Gallegos, C.E.; Dubner, D.L.; Baffa Trasci, S.; Favier, B.; Carosella, E.D.

    2010-01-01

    The physiological and pathological relevance of the HLA-G molecule (non-classical Human Leukocyte Antigen) has been motif of important research studies. Its distribution is restricted to only few tissues. HLA-G takes part in the implantation after in vitro fecundation, in graft tolerance, in auto-immune diseases, and in tumoral immune escape. Its expression has been demonstrated in more than 30% of tumors of 15 different histological types. Gamma radiation modulates HLA-G expression at the cell surface. However, its involvement in tumoral radiosensitivity has not been demonstrated yet. The objective of this work was to demonstrate if the HLA-G molecule intervenes in the radiosensibility of human melanoma cells cultured in vitro. For this purpose we used the human melanoma cell line M8, which was transfected with the plasmid containing the HLA-G gene (M8 HLA-G+) or with the plasmid alone, without the HLA-G gene (M8 pc DNA). Both cell lines were irradiated with 0, 2, 5 y 10 Gy and in all cases survival frequency was determined with the clonogenic assay. We observed a significant reduction in M8 HLA-G+ survival with respect to M8 pc DNA for all irradiation doses and was independent of doses. These results, if confirmed in other histological types, could postulate the HLA-G molecule as a tumoral radiosensitivity marker. The specific mechanism involved in the radiosensibility modification exerted by HLA-G has not been elucidated yet. (authors) [es

  11. 2014 Update of the Pacific Northwest portion of the U.S. National Seismic Hazard Maps

    Science.gov (United States)

    Frankel, Arthur; Chen, Rui; Petersen, Mark; Moschetti, Morgan P.; Sherrod, Brian

    2015-01-01

    Several aspects of the earthquake characterization were changed for the Pacific Northwest portion of the 2014 update of the national seismic hazard maps, reflecting recent scientific findings. New logic trees were developed for the recurrence parameters of M8-9 earthquakes on the Cascadia subduction zone (CSZ) and for the eastern edge of their rupture zones. These logic trees reflect recent findings of additional M8 CSZ earthquakes using offshore deposits of turbidity flows and onshore tsunami deposits and subsidence. These M8 earthquakes each rupture a portion of the CSZ and occur in the time periods between M9 earthquakes that have an average recurrence interval of about 500 years. The maximum magnitude was increased for deep intraslab earthquakes. An areal source zone to account for the possibility of deep earthquakes under western Oregon was expanded. The western portion of the Tacoma fault was added to the hazard maps.

  12. Diseño y desarrollo del hardware de un hólter para pacientes con Parkinson

    OpenAIRE

    Amor Morales, Joan del

    2015-01-01

    El hólter es un dispositivo médico que registra determinados datos (generalmente de origen biométrico) del paciente que lo lleva. Actualmente, el hólter más extendido es el que registra los ritmos cardíacos del paciente. El paciente lleva el hólter durante 24h o 48h haciendo vida normal y, al pasar este período de tiempo, para que los profesionales clínicos puedan tener un registro de la evolución temporal de la actividad eléctrica cardiaca y detectar comportamientos o situaciones patológicas...

  13. Dicty_cDB: Contig-U15683-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ame: Full=Ubiquitin carboxyl-terminal hydrolase 4; ... 41 0.14 BC143354_1( BC143354 |pid:none) Homo sapiens ...pe... 41 0.14 ( Q92353 ) RecName: Full=Ubiquitin carboxyl-terminal hydrolase 6; ... 41 0.14 AC140026_8( AC140026 |pid:none) Med...e-07 1 ( AC116979 ) Dictyostelium discoideum chromosome 2 map 6445720... 54 1e-06 2 ( ER292388 ) 1092343612868 Global-Ocean-Sampli...ing embryo clone:m... 50 4e-05 2 ( EJ238241 ) 1095323012610 Global-Ocean-Sampling_GS-27-01-01-1... 40 3e-04 ...siae mRNA, clone: S03052-24_O... 48 0.35 2 ( EK189498 ) 1095460013501 Global-Ocean-Sampling_GS-31-01-01-1...

  14. Influence of percolation patterns on growth and yield of rice plants and uptake of cadmium from polluted paddy fields using soil dressing models

    OpenAIRE

    パウル, シャマル クマル; PAUL, Shyamal Kumar

    2011-01-01

    We investigated that influence of percolation patterns on growth and yield of rice plants and uptake of cadmium from polluted paddy flelds using soil dressing models. The experiment was conducted in the green house with open and closed system percolation models (M-1,M-2,M-3,M-4,MI5,M-6,MI7,M-8,M-9andM-10). Those models were consisted of stratified soil layers and two different percolation systems (open and closed system percolation) and operated by 12.5cm (M-1 to M-6),15cm (M-7 to M-8) and 20...

  15. Investigation on Strain Development of Azotobacter chroococcum through Chemical Mutagenesis for Indole Acetic Acid Production

    International Nuclear Information System (INIS)

    Ye Lin Win; Myo Myint Han; Myo Myint

    2010-12-01

    Two wild strains of Azotobacter chroococcum were mutagenized by various concentration of NTG (.005% , .0075% and .01%) for 1 hour. The IAA producing activity of 12 effective mutagenized strains were quantitatively measured by UV spectroscopic method. Mutagenized strains M1 and M2 from W1, and M8 and M9 from W2 were selected. Their IAA productivities were 300.498, 216.290, 238.436 and 190.856 ppm, respectively. M1and M9 were higher IAA productivity with greater quality. In germination, M1, M8 and M9 can promote the plant growth compare with commercial IAA.

  16. Evaluation of the VIIRS Ocean Color Monitoring Performance in Coastal Regions

    Science.gov (United States)

    2013-09-17

    Simulations. Applied Optics, 46,1535- 1547 . Wang, M., 8J Bailey. S. W. (2001). Correction of sun glint contamination on the SeaWiFS ocean and...for the validation of ocean color radiance data. IEEE Transactions on Geoscience and Remote Sensing, 42,401-415.

  17. Dynamics of the Dermatologic Microbiome in U.S. Air Force Basic Training

    Science.gov (United States)

    2017-04-05

    TRANSFER AGREEMENT (MTA). INTELLECTUAL PROPERTY RIGHTS AGREEMENT ETC.? 0 YES 181 NO NOTE: If the answer is YES then attach a copy of the Agreement to...participating subjects and capitalizing on the extant process or randomized allocation of new tralM8S Obtatned app<ovat fra<n the 59th Medic.at Wmg

  18. MINOS 5.0 User’s Guide.

    Science.gov (United States)

    1983-12-01

    or the host computer could unexpectedly crash. In this case the basis file will be corrupted and the run will have been essentially wasted. To...C - - ---- ------------ C CYCLE 3. UNWATE A NW COLUM61. C C FOR ILLUSTRATIVE RUFOES IIET UP ml NIN pnULEN ONLT V C ml SOUTION To ml OsM8ff OKnn

  19. Treatment Outcomes and Mediators of Parent Management Training: A One-Year Follow-Up of Children with Conduct Problems

    Science.gov (United States)

    Hagen, Kristine Amlund; Ogden, Terje; Bjornebekk, Gunnar

    2011-01-01

    This effectiveness study presents the results of a 1-year follow-up of a randomized controlled trial of Parent Management Training. Families of 112 Norwegian girls and boys with clinic-level conduct problems participated, and 75 (67%) families were retained at follow-up. Children ranged in age from 4 to 12 at intake (M = 8.44). Families randomized…

  20. Design and construction of double-Blumlein HV pulse power supply

    Indian Academy of Sciences (India)

    Springer Verlag Heidelberg #4 2048 1996 Dec 15 10:16:45

    is based on the principle of connecting the two Blumlein in series to provide twice the output voltage of a single ... The hexagonal flat faces of two M8 SS nuts are aligned parallel to each other. Sharp points are avoided ... for such applications. Due to the capacitance of the point-plane gap with Rm, the circuit acts as a high.

  1. Children's Moral Self-Concept: The Role of Aggression and Parent-Child Relationships

    Science.gov (United States)

    Sengsavang, Sonia; Krettenauer, Tobias

    2015-01-01

    This study examined the role of aggressiveness and parenting in the development of children's moral self-concept. Participants were 198 elementary school children and their parents (M = 8.65 years, SD = 2.44). Participants completed a structured moral self puppet interview and a questionnaire about their relationship to parents. Parents completed…

  2. Stability of extended scalar diquark stars vis-à-vis soliton stars

    Indian Academy of Sciences (India)

    Motivated by relatively large values of the maximum mass ( M = 8 : 92 M ⊙ ) and radius ( = 50.7 km) obtained for an extended scalar diquark star within the framework of an effective 4-theory (S K Karn et al [1]) some interesting observations are made with regard to the stability of stellar objects describable in general in ...

  3. Very Large Graphs for Information Extraction (VLG). Summary of First-Year Proof-of-Concept Study

    Science.gov (United States)

    2013-08-20

    15 700M.---~----~----~------,----, 600M Cl) ’E 500M 8 400M Ci) 0:: 300M .... 0 200M ~ Sep-12 Sep-19 Sep-26 Time Total Proxy Log Records...Large Graphs for Information Extraction (VLG) Summary of First-Year Proof-of-Concept Study 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

  4. 76 FR 19147 - Proposal Review Panel for Physics; Notice of Meeting

    Science.gov (United States)

    2011-04-06

    ...: LIGO Laboratory Annual Review at Livingston Observatory for Physics. Date and Time: Monday, April 25....- 11 a.m. Place: LIGO site at Livingston, Louisiana. Type of Meeting: Partially Closed. Contact Person...LIGO project to the National Science Foundation. Agenda Monday, April 25, 2011 8 a.m.-8:30 a.m. Closed...

  5. Touch Processing and Social Behavior in ASD

    Science.gov (United States)

    Miguel, Helga O.; Sampaio, Adriana; Martínez-Regueiro, Rocío; Gómez-Guerrero, Lorena; López-Dóriga, Cristina Gutiérrez; Gómez, Sonia; Carracedo, Ángel; Fernández-Prieto, Montse

    2017-01-01

    Abnormal patterns of touch processing have been linked to core symptoms in ASD. This study examined the relation between tactile processing patterns and social problems in 44 children and adolescents with ASD, aged 6-14 (M = 8.39 ± 2.35). Multiple linear regression indicated significant associations between touch processing and social problems. No…

  6. Classification of smooth structures on a homotopy complex ...

    Indian Academy of Sciences (India)

    We classify, up to diffeomorphism, all closed smooth manifolds homeomorphic to the complex projective n -space C P n , where n = 3 and 4. Let M 2 n be a closed smooth 2 n -manifold homotopy equivalent to C P n . We show that, up to diffeomorphism, M 6 has a unique differentiable structure and M 8 has at most two ...

  7. Friendship Quality and School Achievement: A Longitudinal Analysis during Primary School

    Science.gov (United States)

    Zucchetti, Giulia; Candela, Filippo; Sacconi, Beatrice; Rabaglietti, Emanuela

    2015-01-01

    This study examined the longitudinal relationship between friendship quality (positive and negative) and school achievement among 228 school-age children (51% girls, M = 8.09, SD = 0.41). A three-wave cross-lagged analysis was used to determine the direction of influence between these domains across school years. Findings revealed that: (a) school…

  8. Disease: H00265 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available M:8:1:147 ... PMID:19838196 (gene) ... AUTHORS ... Kurth I, Pamminger T, Hennings JC, Soehendra D, Huebner AK, Rott... (gene) ... AUTHORS ... Woods CG, Babiker MO, Horrocks I, Tolmie J, Kurth I ... TITLE ... ...econinck T, Timmerman V, Kaether C, De Jonghe P, Hubner CA, Gal A, Amling M, Mundlos S, Baets J, Kurth I ... T

  9. 2017 Valparaíso earthquake sequence and the megathrust patchwork of central Chile

    NARCIS (Netherlands)

    Nealy, Jennifer L.; Herman, Matthew W.; Moore, Ginevra L.; Hayes, Gavin P.; Benz, Harley M.; Bergman, Eric A.; Barrientos, Sergio E.

    2017-01-01

    In April 2017, a sequence of earthquakes offshore Valparaíso, Chile, raised concerns of a potential megathrust earthquake in the near future. The largest event in the 2017 sequence was a M6.9 on 24 April, seemingly colocated with the last great-sized earthquake in the region—a M8.0 in March 1985.

  10. Intermediate-term middle-range predictions in Italy: a review

    International Nuclear Information System (INIS)

    Peresan, A.; Kossobokov, V.; Romashkova, L.; Panza, G.F.

    2003-11-01

    The Italian territory has been object of several studies devoted to the analysis of seismicity and to earthquake precursors' research. Although a number of observations have been claimed to precede large earthquakes, only few systematic studies have been carried out and almost no test of their performances is available up to now. In this paper we review the application to the Italian territory of two formally defined intermediate-term middle-range earthquake prediction algorithms, namely CN and M8S. The general methodology common to the two different algorithms makes use of general concepts of pattern recognition that permit to deal with multiple sets of seismic precursors, and allows for a systematic monitoring of seismicity, as well as for a widespread testing of the prediction performances. Italy represents the only region of moderate seismic activity where the M8S and CN algorithms are applied simultaneously for the routine monitoring. Significant efforts have been made to minimize the intrinsic space uncertainty of predictions and the subjectivity of the definition of the areas where precursors should be identified. Several experiments have been dedicated to assess the robustness of the methodology against the unavoidable uncertainties in the data. With these results acquired, predictions are routinely issued by CN algorithm, since January 1998, and by M8S algorithm, since January 2002. Starting in July 2003 an experiment has been launched for the real-time test of M8S and CN predictions. (author)

  11. Reappraisal of the 2010 Maule, 2014 Iquique, 2015 Illapel through Inversion of Geodetic Data and Tsunami Waveforms Using the Optimal Time Alignment (OTA) Method

    Science.gov (United States)

    Romano, F.; Lorito, S.; Piatanesi, A.; Volpe, M.; Lay, T.; Tolomei, C.; Murphy, S.; Tonini, R.; Escalante, C.; Castro, M. J.; Gonzalez-Vida, J. M.; Macias, J.

    2017-12-01

    The Chile subduction zone is one of the most seismically active regions in the world and it hosted a number of great tsunamigenic earthquakes in the past. In particular, during the last 7 years three M8+ earthquakes occurred nearby the Chilean coasts, that is the 2010 M8.8 Maule, the 2014 M8.1 Iquique, and the M8.3 2015 Illapel earthquakes. The rupture process of these earthquakes has been studied by using different kind of geophysical observations such as seismic, geodetic, and tsunami data; in particular, tsunami waveforms are important for constraining the slip on the offshore portion of the fault. However, it has been shown that forward modelling of tsunami data can be affected by unavailability of accurate bathymetric models, especially in the vicinity of the tide-gauges; and in the far field by water density gradients, ocean floor elasticity, or geopotential gravity changes, generally neglected. This could result in a mismatch between observed and predicted tsunami signals thus affecting the retrieved tsunami source image. Recently, a method has been proposed for automatic correction during the nonlinear inversion of the mismatch (optimal time alignment, OTA; Romano et al., GRL, 2016). Here, we present a reappraisal of the joint inversion of tsunami data with OTA procedure and geodetic data, for the Maule, Iquique, and Illapel earthquakes. We compare the results with those obtained by tsunami inversion without using OTA and with other published inversion results.

  12. Safety and pharmacokinetics of nelfinavir during the second and third trimesters of pregnancy and postpartum.

    Science.gov (United States)

    Fang, A; Valluri, S R; O'Sullivan, M-J; Maupin, R; Jones, T; Delke, I; Clax, P

    2012-01-01

    Evaluate the safety, tolerability, and pharmacokinetics (PK) of nelfinavir during pregnancy and postpartum in HIV-infected women. Phase IV, non-randomized, open-label study of nelfinavir 625 mg tablets (1250 mg) in combination with lamivudine/zidovudine twice daily. Primary endpoint was treatment-related or possibly treatment-related gastrointestinal or hepatic adverse events (AEs). Selected maternal and infant outcomes were recorded. Frequent plasma samples were collected for PK studies during the 2nd and 3rd trimesters, and 6 weeks postpartum, to analyze total and free nelfinavir and M8 concentrations. Sixteen HIV+ pregnant women were enrolled. Six mild treatment-related AEs and 3 serious AEs occurred; 1 serious AE (elevated AST) met the primary endpoint. Compared with 6 weeks postpartum, levels of total nelfinavir were reduced by 44% and 46%, total M8 by 82% and 83%, free nelfinavir by 48% and 39%, and free M8 by 83% and 79% in the 2nd and 3rd trimesters, respectively. At 6 weeks postpartum, 75% and 50% of subjects maintained HIV-1 RNA levels <400 and <50 copies/mL, respectively. All pregnancies resulted in live births without transmission in 15 infants. Nelfinavir in combination with lamivudine/zidovudine was generally well tolerated. Total and free nelfinavir and M8 exposure were reduced in late pregnancy.

  13. Stages and Discharges of the Mississippi River and Tributaries and Other Watersheds in the New Orleans District for 1991

    Science.gov (United States)

    1991-01-01

    234 GULF OF MEXICO . . . . ..................... 263 PART II. OBSERVED DISCHARGES MISSISSIPPI RIVERANDPASSES ......... ............... 271 OLD...DISCHARGE IN THOUSAND DAY SECOND FEET DAY JAN FEB NAR APR NAY AtUN Jt. AUG SEP OCT NOV DEC 226215 125 83 33 32 90 64 37 m8 90 279 92 5 63 21 2m 224 127

  14. Classification of smooth structures on a homotopy complex ...

    Indian Academy of Sciences (India)

    Abstract. We classify, up to diffeomorphism, all closed smooth manifolds homeo- morphic to the complex projective n-space CPn, where n = 3 and 4. Let M2n be a closed smooth 2n-manifold homotopy equivalent to CPn. We show that, up to diffeo- morphism, M6 has a unique differentiable structure and M8 has at most two ...

  15. Development of Social Category Representations: Early Appreciation of Roles and Deontic Relations

    Science.gov (United States)

    Kalish, Charles W.; Lawson, Christopher A.

    2008-01-01

    Three experiments explored the significance of deontic properties (involving rights and obligations) in representations of social categories. Preschool-aged children (M = 4.8), young school-aged children (M = 8.2), and adults judged the centrality of behavioral, psychological, and deontic properties for both familiar (Experiments 1 and 2, Ns = 50…

  16. Medicinal flowers. XXX. Eight new glycosides, everlastosides F-M, from the flowers of Helichrysum arenarium.

    Science.gov (United States)

    Morikawa, Toshio; Wang, Li-Bo; Ninomiya, Kiyofumi; Nakamura, Seikou; Matsuda, Hisashi; Muraoka, Osamu; Wu, Li-Jun; Yoshikawa, Masayuki

    2009-08-01

    Eight new glycosides, everlastosides F (1), G (2), H (3), I (4), J (5), K (6), L (7), and M (8), were isolated from the methanolic extract of the flowers of Helichrysum arenarium. Their structures were elucidated on the basis of chemical and physicochemical evidence.

  17. Parents' Role in Adolescents' Decision on a College Major: A Weekly Diary Study

    Science.gov (United States)

    Dietrich, Julia; Kracke, Barbel; Nurmi, Jari-Erik

    2011-01-01

    This study examined 39 adolescents during their transition to university. In standardized weekly diaries over several weeks (M=8.13) adolescents reported on engagement in career exploration (in-breadth and in-depth self and environmental exploration), their parents' transition-related involvement (frequency of conversations, support, and…

  18. Concurrent and Longitudinal Relations between Children's Sleep and Cognitive Functioning: The Moderating Role of Parent Education

    Science.gov (United States)

    Buckhalt, Joseph A.; El-Sheikh, Mona; Keller, Peggy S.; Kelly, Ryan J.

    2009-01-01

    Relations between children's sleep and cognitive functioning were examined over 2 years, and race and socioeconomic status were assessed as moderators of effects. Third-grade African American and European American children (N = 166; M = 8.72 years) participated at Time 1 and again 2 years later (N = 132). At both Time 1 and Time 2, sleep was…

  19. Children's Sleep and Adjustment over Time: The Role of Socioeconomic Context

    Science.gov (United States)

    El-Sheikh, Mona; Kelly, Ryan J.; Buckhalt, Joseph A.; Hinnant, J. Benjamin

    2010-01-01

    Relations were examined between children's sleep and their externalizing and internalizing symptoms. Longitudinal relations were examined when children were in 3rd (T1) and 5th (T2) grades, and cross-sectional relations were assessed at T2. Participants included 176 children at T1 (M = 8.68 years) and 141 children at T2 (M = 10.70 years). Sleep…

  20. Social Problems as a Mediator of the Link between Reactive Aggression and Withdrawn/Depressed Symptoms

    Science.gov (United States)

    Fite, Paula J.; Rathert, Jamie L.; Stoppelbein, Laura; Greening, Leilani

    2012-01-01

    The current study examined whether social problems accounted for the relation between reactive aggression and withdrawn/depressed symptoms in a sample of 147 children (54.4% male) ranging from 5 to 13 years of age (M = 8.22 years) who attended a community based after-school program. Findings suggested that indeed social problems mediated the link…

  1. Probabilistic seismic hazard assessment of NW and central ...

    Indian Academy of Sciences (India)

    the Assam Earthquake of 1950 (M=8.5). It is important to carry out seismic hazard analysis of the region because of its high level of natural seismicity and the presence of segments of major longitudinal tectonic boundary thrusts, namely the Main Central Trust (MCT) and the Main. Boundary Thrust (MBT) along with various ...

  2. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    pp 921-931. Water use efficiency of net primary production in global terrestrial ecosystems · Lei Xia Fei Wang Xingmin Mu Kai Jin Wenyi Sun ..... An application of earthquake prediction algorithm M8 in eastern Anatolia at the approach of the 2011 Van earthquake · Masoud Mojarab Vladimir Kossobokov Hossein Memarian ...

  3. Download this PDF file

    African Journals Online (AJOL)

    Fr. Ikenga

    5 See the Medical and Dental Practitioners Act (Cap M8) Laws of the Federation of Nigeria, 2010 ... point out that the rate at which issues of medical negligence in form of wrong diagnosis are been left unchallenged in ... of a patient by a physician, dentist, nurse, pharmacist or other health care professional.16 The concept.

  4. A new carbamidemethyl-linked lanthanoid chelating tag for PCS NMR spectroscopy of proteins in living HeLa cells

    Energy Technology Data Exchange (ETDEWEB)

    Hikone, Yuya [Tokyo Metropolitan University, Department of Chemistry, Graduate School of Science and Engineering (Japan); Hirai, Go [RIKEN, Synthetic Organic Chemistry Laboratory (Japan); Mishima, Masaki [Tokyo Metropolitan University, Department of Chemistry, Graduate School of Science and Engineering (Japan); Inomata, Kohsuke [RIKEN, Quantitative Biology Center (Japan); Ikeya, Teppei; Arai, Souichiro [Tokyo Metropolitan University, Department of Chemistry, Graduate School of Science and Engineering (Japan); Shirakawa, Masahiro [Japan Agency for Medical Research and Development, AMED-CREST (Japan); Sodeoka, Mikiko [RIKEN, Synthetic Organic Chemistry Laboratory (Japan); Ito, Yutaka, E-mail: ito-yutaka@tmu.ac.jp [Tokyo Metropolitan University, Department of Chemistry, Graduate School of Science and Engineering (Japan)

    2016-10-15

    Structural analyses of proteins under macromolecular crowding inside human cultured cells by in-cell NMR spectroscopy are crucial not only for explicit understanding of their cellular functions but also for applications in medical and pharmaceutical sciences. In-cell NMR experiments using human cultured cells however suffer from low sensitivity, thus pseudocontact shifts from protein-tagged paramagnetic lanthanoid ions, analysed using sensitive heteronuclear two-dimensional correlation NMR spectra, offer huge potential advantage in obtaining structural information over conventional NOE-based approaches. We synthesised a new lanthanoid-chelating tag (M8-CAM-I), in which the eight-fold, stereospecifically methylated DOTA (M8) scaffold was retained, while a stable carbamidemethyl (CAM) group was introduced as the functional group connecting to proteins. M8-CAM-I successfully fulfilled the requirements for in-cell NMR: high-affinity to lanthanoid, low cytotoxicity and the stability under reducing condition inside cells. Large PCSs for backbone N–H resonances observed for M8-CAM-tagged human ubiquitin mutant proteins, which were introduced into HeLa cells by electroporation, demonstrated that this approach readily provides the useful information enabling the determination of protein structures, relative orientations of domains and protein complexes within human cultured cells.

  5. Trainer’s Guide: Multipurpose Arcade Combat Simulator: Moving Target Training

    Science.gov (United States)

    1992-09-01

    Information Center (DTIC) to comply with regulatory requirements. It has been given no primary distribution other than to DTIC and will be available... thoote / : 6T*er shockv er %fro tiIoAwI 3: 7 Ovsly lmmn Wtto 64M 8: 9sh.kd shoote froem righ to Wt 4-6 * Now return to skill level. SEnter to return

  6. A new carbamidemethyl-linked lanthanoid chelating tag for PCS NMR spectroscopy of proteins in living HeLa cells

    International Nuclear Information System (INIS)

    Hikone, Yuya; Hirai, Go; Mishima, Masaki; Inomata, Kohsuke; Ikeya, Teppei; Arai, Souichiro; Shirakawa, Masahiro; Sodeoka, Mikiko; Ito, Yutaka

    2016-01-01

    Structural analyses of proteins under macromolecular crowding inside human cultured cells by in-cell NMR spectroscopy are crucial not only for explicit understanding of their cellular functions but also for applications in medical and pharmaceutical sciences. In-cell NMR experiments using human cultured cells however suffer from low sensitivity, thus pseudocontact shifts from protein-tagged paramagnetic lanthanoid ions, analysed using sensitive heteronuclear two-dimensional correlation NMR spectra, offer huge potential advantage in obtaining structural information over conventional NOE-based approaches. We synthesised a new lanthanoid-chelating tag (M8-CAM-I), in which the eight-fold, stereospecifically methylated DOTA (M8) scaffold was retained, while a stable carbamidemethyl (CAM) group was introduced as the functional group connecting to proteins. M8-CAM-I successfully fulfilled the requirements for in-cell NMR: high-affinity to lanthanoid, low cytotoxicity and the stability under reducing condition inside cells. Large PCSs for backbone N–H resonances observed for M8-CAM-tagged human ubiquitin mutant proteins, which were introduced into HeLa cells by electroporation, demonstrated that this approach readily provides the useful information enabling the determination of protein structures, relative orientations of domains and protein complexes within human cultured cells.

  7. Streptococcus oricebi sp. nov., isolated from the oral cavity of tufted capuchin.

    Science.gov (United States)

    Saito, M; Shinozaki-Kuwahara, N; Hirasawa, M; Takada, K

    2016-02-01

    A Gram-stain-positive, catalase-negative, coccus-shaped organism was isolated from the oral cavity of tufted capuchin (Cebus apella). Comparative 16S rRNA gene sequence analysis suggested classification of the organism within the genus Streptococcus. Strain M8T was related most closely to Streptococcus oralis ATCC 35037T (96.17 % similarity) followed by Streptococcus massiliensis CCUG 49690T (95.90 %) based on the 16S rRNA gene. Strain M8T was related most closely to S. massiliensis CCUG 49690T (86.58 %) based on the RNA polymerase β subunit-encoding gene (rpoB), and to Streptococcus tigurinus AZ_3aT (81.26 %) followed by S. massiliensis CCUG 49690T (80.45 %) based on the 60 kDa heat-shock protein gene (groEL). The phylogenetic trees of 16S rRNA, rpoB and groEL gene sequences showed that strain M8T was most closely related to S. massiliensis. Based on phenotypic characterization as well as 16S rRNA gene and housekeeping gene (rpoB and groEL) sequence data, a novel taxon, Streptococcus oricebi sp. nov. (type strain M8T = JCM 30719T = DSM 100101T), is proposed.

  8. César Augusto Restrepo Valencia, Consuelo Vélez Álvarez Abstract Objective. To evaluate the effectiveness of calcineurin ciclosporin and tacrolimus inhibitors to induce remission in patients with refractory lupus nephritis. Patients, materials and methods. Patients with lupus nephritis class IV-G who despite receiving therapy with high doses of steroid and with a cytostatic (cyclophosphamide or mycophenolate for 3 months had not been able to induce some kind of remission.The exclusion criteria were creatinine levels greater than 3 mg / dl, pregnancy, previous history of exposure to calcineurin inhibitors, cancer, active infections, uncontrolled hypertension, and negligence with medication intake. The recommended dose of cyclosporine was 3 mg / kg / day and tacrolimus 0.1 mg / kg / day, in joint with prednisone 0.3 mg / kg / day, cyclophosphamide 1 mg / kg / day or mycophenolate mofetil 1 gram every 12 hours. The cyclophosphamide was administered only during 6 months, after which it was changed to azathioprine at doses of 1 mg / kg / day. Still, mycophenolate was continued at the same dose. All patients completed a minimum period of 12 months follow-up, it was considered that patients achieved partial remission when proteinuria decreased by 50% of the baseline value or its value decreased to less than 1 gram in 24 hours, decrease of leukocytes count and red blood cells in urine of 50%, and creatinine values were stable. A complete remission was considered when there was a reduction in proteinuria in a value less than 300 mg per 24 hours, urinary sediment with less than 3 red blood cells, less than 5 leukocyte for each high power microscopic field, and a creatinine value reduction by 50% or reaching a normal value. Results. Twelve patients met the inclusion criteria and initiated the calcineurin inhibitor protocol. Two presented accelerated deterioration in their function and required chronic dialysis therapy. Ten patients with active treatment completed 12 months

    Directory of Open Access Journals (Sweden)

    César Augusto Restrepo Valencia

    2014-10-01

    Full Text Available Objective: To evaluate the effectiveness of calcineurin ciclosporin and tacrolimus inhibitors to induce remission in patients with refractory lupus nephritis. Patients, materials and methods: Patients with lupus nephritis class IV-G who despite receiving the rapy with high doses of steroid and with a cytostatic (cyclophosphamide or mycophenolate for 3 months had not been able to induce some kind of remission.The exclusion criteria were creatinine levels greater than 3 mg / dl, pregnancy, previous history of exposure to calcineurin inhibitors, cancer, active infections, uncontrolled hypertension, and negligence with medication intake. The recommended dose of cyclosporine was 3 mg / kg / day and tacrolimus 0.1 mg / kg / day, in joint with prednisone 0.3 mg / kg / day, cyclophosphamide 1 mg / kg / day or mycophenolate mofetil 1 gram every 12 hours. The cyclophosphamide was administered only during 6 months, after which it was changed to azathioprine at doses of 1 mg / kg / day. Still, mycophenolate was continued at the same dose. All patients completed a minimum period of 12 months follow-up, it was considered that patients achieved partial remission when proteinuria decreased by 50% of the baseline value or its value decreased to less than 1 gram in 24 hours, decrease of leukocytes count and red blood cells in urine of 50%, and creatinine values were stable. A complete remission was considered when there was a reduction in proteinuria in a value less than 300 mg per 24 hours, urinary sediment with less than 3 red blood cells, less than 5 leukocyte for each high power microscopic field, and a creatinine value reduction by 50% or reaching a normal value. Results: Twelve patients met the inclusion criteria and initiated the calcineurin inhibitor protocol. Two presented accelerated deterioration in their function and required chronic dialysis therapy. Ten patients with active treatment completed 12 months of followup, of which 4 (40% had partial

  9. Earthquake Triggering in the September 2017 Mexican Earthquake Sequence

    Science.gov (United States)

    Fielding, E. J.; Gombert, B.; Duputel, Z.; Huang, M. H.; Liang, C.; Bekaert, D. P.; Moore, A. W.; Liu, Z.; Ampuero, J. P.

    2017-12-01

    Southern Mexico was struck by four earthquakes with Mw > 6 and numerous smaller earthquakes in September 2017, starting with the 8 September Mw 8.2 Tehuantepec earthquake beneath the Gulf of Tehuantepec offshore Chiapas and Oaxaca. We study whether this M8.2 earthquake triggered the three subsequent large M>6 quakes in southern Mexico to improve understanding of earthquake interactions and time-dependent risk. All four large earthquakes were extensional despite the the subduction of the Cocos plate. The traditional definition of aftershocks: likely an aftershock if it occurs within two rupture lengths of the main shock soon afterwards. Two Mw 6.1 earthquakes, one half an hour after the M8.2 beneath the Tehuantepec gulf and one on 23 September near Ixtepec in Oaxaca, both fit as traditional aftershocks, within 200 km of the main rupture. The 19 September Mw 7.1 Puebla earthquake was 600 km away from the M8.2 shock, outside the standard aftershock zone. Geodetic measurements from interferometric analysis of synthetic aperture radar (InSAR) and time-series analysis of GPS station data constrain finite fault total slip models for the M8.2, M7.1, and M6.1 Ixtepec earthquakes. The early M6.1 aftershock was too close in time and space to the M8.2 to measure with InSAR or GPS. We analyzed InSAR data from Copernicus Sentinel-1A and -1B satellites and JAXA ALOS-2 satellite. Our preliminary geodetic slip model for the M8.2 quake shows significant slip extended > 150 km NW from the hypocenter, longer than slip in the v1 finite-fault model (FFM) from teleseismic waveforms posted by G. Hayes at USGS NEIC. Our slip model for the M7.1 earthquake is similar to the v2 NEIC FFM. Interferograms for the M6.1 Ixtepec quake confirm the shallow depth in the upper-plate crust and show centroid is about 30 km SW of the NEIC epicenter, a significant NEIC location bias, but consistent with cluster relocations (E. Bergman, pers. comm.) and with Mexican SSN location. Coulomb static stress

  10. Selection and characterization of coal mine autochthonous rhizobia for the inoculation of herbaceous legumes.

    Science.gov (United States)

    Hernández, Anabel González; de Moura, Ginaini Doin; Binati, Renato Leal; Nascimento, Francisco Xavier Inês; Londoño, Diana Morales; Mamede, Ana Carolina Peixoto; da Silva, Emanuela Pille; de Armas, Rafael Dutra; Giachini, Admir José; Rossi, Márcio José; Soares, Cláudio Roberto Fonsêca Sousa

    2017-09-01

    Coal open pit mining in the South of Santa Catarina state (Brazil) was inappropriately developed, affecting approximately 6.700 ha. Re-vegetation is an alternative for the recovery of these areas. Furthermore, the use of herbaceous legumes inoculated with nitrogen fixing bacteria is motivated due to the difficulty implementing a vegetation cover in these areas, mainly due to low nutrient availability. Therefore, the aim of this work was to evaluate, among 16 autochthonous rhizobia isolated from the coal mining areas, those with the greatest potential to increase growth of the herbaceous legumes Vicia sativa and Calopogonium mucunoides. Tests were conducted in greenhouse containing 17 inoculation treatments (16 autochthonous rhizobia + Brazilian recommended strain for each plant species), plus two treatments without inoculation (with and without mineral nitrogen). After 60 days, nodulation, growth, N uptake, and symbiotic efficiency were evaluated. Isolates characterization was assessed by the production of indole acetic acid, ACC deaminase, siderophores, and inorganic phosphate solubilization. The classification of the isolates was performed by 16 S rDNA gene sequencing. Only isolates UFSC-M4 and UFSC-M8 were able to nodulate C. mucunoides. Among rhizobia capable of nodulating V. sativa, only UFSC-M8 was considered efficient. It was found the presence of more than one growth-promoting attributes in the same organism, and isolate UFSC-M8 presented all of them. Isolates were classified as belonging to Rhizobium, Burkholderia and Curtobacterium. The results suggest the inoculation of Vicia sativa with strain UFSC-M8, classified as Rhizobium sp., as a promising alternative for the revegetation of coal mining degraded areas.

  11. Paleoearthquakes and long-term seismic regime in the Longmenshan fault zone, Southwest China

    Science.gov (United States)

    Liu, J.; Rodina, S. N.; Rogozhin, E. A.

    2017-11-01

    The collected paleoseismological data about the ancient earthquakes are analyzed for the zone of the Wenchuan earthquake. Four earthquakes with magnitude M = 8.0 occurred over a period of 10000 years and two earthquakes with magnitude 7.5 occurred over 1200 years. The obtained data allowed us to reconstruct the long-term seismic regime within the studied territory by constructing the frequency-magnitude relationship based on the instrumental, historical, and paleoseismological data.

  12. C-Bag Consolidation: An Inventory and Safety Stock Analysis

    Science.gov (United States)

    2014-06-13

    AND SAFETY STOCK ANALYSIS GRADUATE RESEARCH PAPER Presented to the Faculty Graduate School of Engineering and Management Air Force...i.e. pilots, firefighters) was excluded from this research. Any items found in both the A-bag and C-bag (helmet, web belt, canteen , etc.) were also...M8 detector paper booklet, M9 detector paper roll, M258A1 or M291 decontamination kit, M295 decontamination kit, a web belt, canteen , M1 canteen

  13. Understanding Great Earthquakes in Japan's Kanto Region

    Science.gov (United States)

    Kobayashi, Reiji; Curewitz, Daniel

    2008-10-01

    Third International Workshop on the Kanto Asperity Project; Chiba, Japan, 16-19 February 2008; The 1703 (Genroku) and 1923 (Taisho) earthquakes in Japan's Kanto region (M 8.2 and M 7.9, respectively) caused severe damage in the Tokyo metropolitan area. These great earthquakes occurred along the Sagami Trough, where the Philippine Sea slab is subducting beneath Japan. Historical records, paleoseismological research, and geophysical/geodetic monitoring in the region indicate that such great earthquakes will repeat in the future.

  14. Diurnal variation of. beta. -endorphin like immunoreactivity in rat brain, pituitary gland, and plasma

    Energy Technology Data Exchange (ETDEWEB)

    Izquierdo, I.A.; Perry, M.L.S.; Carrasco, M.A.; Dias, R.D. (Rio Grande do Sul Univ., Porto Alegre (Brazil). Inst. de Biociencias); Orsingher, O.A. (Universidad Nacional de Cordoba (Argentina))

    1984-09-01

    ..beta..-endorphin like immunoreactivity was measured in the brain, pituitary gland and plasma of rats at 2 A.M, 8 A.M, 2 P.M and 8 P.M. Values were higher in the brain and pituitary gland at 8 P.M and in the plasma at 8 A.M and 2 P.M. The findings suggest a circadian rhythm in the production and release of ..beta..-endorphin immunoreactive material.

  15. TRPM8 and Migraine

    OpenAIRE

    Dussor, Greg; Cao, Yu-Qing

    2016-01-01

    Migraine is among the most common diseases on earth and one of the most disabling, the latter due in large part to poor treatment efficacy. Development of new therapeutics is dependent on the identification of mechanisms contributing to migraine and discovery of targets for new drugs. Numerous genome-wide association studies (GWAS) have implicated the transient receptor-potential M8 (TRPM8) channel in migraine. This channel is predominantly expressed on peripheral sensory neurons and is known...

  16. 77 FR 27804 - Proposal Review Panel for Chemistry; Notice of Meeting

    Science.gov (United States)

    2012-05-11

    ... announces the following meeting: Name: Centers for Chemical Innovation (CCI) Solar Fuels: Powering the... support. Agenda: Tuesday, May 22, 2012 7:00 p.m.-9:00 p.m. Executive Session (Closed) Wednesday, May 23, 2012 7:00 a.m. -8:15 a.m. Executive Session (Closed) 8:15 a.m.-12:10 p.m. Welcome & Session 1 (Center...

  17. A Longitudinal Study of Children's Theory of Mind and Drawings of Play

    Science.gov (United States)

    Bosacki, Sandra L.

    2013-01-01

    This study investigated the longitudinal relations between theory of mind (ToM) understanding and children's drawings of play in 26 school-aged children, (16 females, 10 males, aged 8-12 years). Theory of mind was assessed at Time 1 (T1, M = 8 y 5m) and two years later at Time 2 (T2, M =10 y 4 m), as well as children's drawings of play activities.…

  18. A Longitudinal Study of Children's Theory of Mind, Self-Concept, and Gender-Role Orientation

    Science.gov (United States)

    Bosacki, Sandra Leanne

    2014-01-01

    This study investigated the longitudinal relations between theory of mind (ToM) understanding, self-perceptions, and perceptions of gender-role orientation in 28 school-aged children, (16 girls, 12 boys, aged 8-12 years). Theory of mind and perceptions of self were assessed at Time 1 (T1, M = 8 y 5 m) and two years later at Time 2 (T2, M = 10 y 4…

  19. Supporting Information_Revised

    Indian Academy of Sciences (India)

    Acer

    chromene (4p). IR νmax (KBr): 3430, 3340, 3030, 2200, 1710, 1040 cm. -1 . 1. H NMR (400 MHz, CDCl3): δ 3.80 (s,. 3H), 5.19 (s, 1H), 6.82-7.50 (m, 8H, Ar-H), 8.24 (s, 2H);. 13. C NMR (100 MHz, CDCl3): δ 40.0,. 56.0, 65.0, 101.2, 112.3, 114.8, ...

  20. Symposium on Toxic Substance Control: Decontamination, April 22 - 24, 1980, Columbus, Ohio.

    Science.gov (United States)

    1981-06-01

    color change when a nerve, blister, or blood agent is present. The M256 kit also contains ABC M-8 de- tector paper that is used to blot the surfaces...with waste dumps), simple combustion is not fully effective and the resultant emissions must be filtered . Then the filters themselves present a...Fabrics by the Tongue (Single Rip) Method (Constant-Rate-of-Traverse Tensile Testing Machine) ASTM D-2262 Nonwoven Fabrics, Testing ASTM D-1 117

  1. Mechanisms of the Testis Toxicity Induced by Chronic Exposure to Mequindox

    Directory of Open Access Journals (Sweden)

    Qianying Liu

    2017-09-01

    Full Text Available Mequindox (MEQ is a synthetic antimicrobial agent widely used in China since the 1980s. Although the toxicity of MEQ is well recognized, its testis toxicity has not been adequately investigated. In the present study, we provide evidence that MEQ triggers oxidative stress, mitochondrion dysfunction and spermatogenesis deficiency in mice after exposure to MEQ (0, 25, 55, and 110 mg/kg in the diet for up to 18 months. The genotoxicity and adrenal toxicity may contribute to sperm abnormalities caused by MEQ. Moreover, using LC/MS-IT-TOF analysis, two metabolites, 3-methyl-2-(1-hydroxyethyl quinoxaline-N4-monoxide (M4 and 3-methyl-2-(1-hydroxyethyl quinoxaline-N1-monoxide (M8, were detected in the serum of mice, which directly confirms the relationship between the N→O group reduction metabolism of MEQ and oxidative stress. Interestingly, only M4 was detected in the testes, suggesting that the higher reproductive toxicity of M4 than M8 might be due to the increased stability of M4-radical (M4-R compared to M8-radical (M8-R. Furthermore, the expression of the blood-testis barrier (BTB-associated junctions such as tight junctions, gap junctions and basal ectoplasmic specializations were also examined. The present study demonstrated for the first time the role of the M4 in testis toxicity, and illustrated that the oxidative stress, mitochondrion dysfunction and interference in spermatogenesis, as well as the altered expression of BTB related junctions, were involved in the reproductive toxicity mediated by MEQ in vivo.

  2. The Impacts of Various Types of Advertising Media, Demographics, and Recruiters on Quality Enlistments: Results from Simultaneous and Heteroscedastic Models.

    Science.gov (United States)

    1980-07-01

    136 $ .738M 8) Urban/Riral Mix .192 .41 9) Propensity .674 .64 10) Overall Unemployment Rate .18 .24 5.86% nationally Youth Unemployment Rate .257 .34...unemployment rate. Fernandez (1980) and Cooper (1978) have both studied the relationship between youth unemployment and total unem- ployment via regression...Fernandez utilizes a relationship that converts overall unemployment to youth unemployment by raising overall unemployment %I to the power .699. Cooper

  3. In search of the causes of autism; A la recherche des causes de l`autisme

    Energy Technology Data Exchange (ETDEWEB)

    Garreau, B.; Zilbovicius, M. [Hopital Bretonneau, 37 - Tours (France)

    1996-07-01

    After having been considered as a trouble of the mother-child relation, the infant autism is nowadays for a lot of specialists the consequence of a mental disorder. The functional cerebral imagery (NMR imaging, single photon computed tomography, positron computed tomography) can prove it. Particularly, it reveals a delay of the frontal lobes at autistic young children and in some cases an abnormal reaction of the cerebral cortex at sensorial stimulations. (O.M.). 8 refs.

  4. Simultaneous determination of morinidazole, its N-oxide, sulfate, and diastereoisomeric N(+)-glucuronides in human plasma by liquid chromatography-tandem mass spectrometry.

    Science.gov (United States)

    Gao, Ruina; Zhong, Dafang; Liu, Ke; Xia, Yu; Shi, Rongwei; Li, Hua; Chen, Xiaoyan

    2012-11-01

    Morinidazole is a new third-generation 5-nitroimidazole antimicrobial drug. To investigate the pharmacokinetic profiles of morinidazole and its major metabolites in humans, a liquid chromatography-tandem mass spectrometry method was developed and validated for simultaneous determination of morinidazole, its N-oxide metabolite (M4-1), a sulfate conjugate (M7), and two diastereoisomeric N(+)-glucuronides (M8-1 and M8-2) in human plasma. A simple acetonitrile-induced protein precipitation was employed to extract five analytes and internal standard metronidazole from 50μL human plasma. To avoid the interference from the in-source dissociation of the sulfate and achieve the baseline-separation of diastereoisomeric N(+)-glucuronides, all the analytes were separated from each other with the mobile phase consisting of 10mM ammonium formate and acetonitrile using gradient elution on a Hydro-RP C(18) column (50mm×2mm, 4μm) with a total run time of 5min. The API 4000 triple quadrupole mass spectrometer was operated under the multiple reaction-monitoring mode using the electrospray ionization technique. The developed method was linear in the concentration ranges of 10.0-12,000ng/mL for morinidazole, 1.00-200ng/mL for M4-1, 2.50-500ng/mL for M7, 3.00-600ng/mL for M8-1, and 10.0-3000ng/mL for M8-2. The intra- and inter-day precisions for each analyte met the accepted value. Results of the stability of morinidazole and its metabolites in human plasma were also presented. The method was successfully applied to the clinical pharmacokinetic studies of morinidazole injection in healthy subjects, patients with moderate hepatic insufficiency, and patients with severe renal insufficiency, respectively. Copyright © 2012 Elsevier B.V. All rights reserved.

  5. USAF/SCEEE (Southeastern Center for Electrical Engineering Education) Air Force Geophysics Program 1985-1986.

    Science.gov (United States)

    1986-11-01

    solution for these equations at present are iterative. The Newton -Raphson iterative procedure may be used to obtain a rapidly converging solution the...8217*𔃻 12 References Cardwell, R.K., E.S. Kappel, M.S. Lawrence, and B L Isacks (1981) Plate convergence along the Indonesian arc...trench (possibly related to sharp downbending of the oceanic plate) [Cardwell and Isacks , 19781, including the M -8.1 Sumba earthquake of 1977. The

  6. The Role of Dosimetry in High-Quality EMI Risk Assessment

    Science.gov (United States)

    2006-09-14

    probe in the hypothalamus and cortex and exposed to eight different orientations in the far field. Comparison between these data and FDTD predictions...Limits M1 M2 M3 M4 M5 M10 M11 M12 M6 M8 M7 M9 Road Fig 3. A sketch of the camp and the surrounding area showing the points of

  7. Use of induced pluripotent stem cell models to probe the pathogenesis of Choroideremia and to develop a potential treatment

    Directory of Open Access Journals (Sweden)

    Thu T. Duong

    2018-03-01

    Full Text Available Choroideremia (CHM is a rare monogenic, X-linked recessive inherited retinal degeneration resulting from mutations in the Rab Escort Protein-1 (REP1 encoding CHM gene. The primary retinal cell type leading to CHM is unknown. In this study, we explored the utility of induced pluripotent stem cell-derived models of retinal pigmented epithelium (iPSC-RPE to study disease pathogenesis and a potential gene-based intervention in four different genetically distinct forms of CHM. A number of abnormal cell biologic, biochemical, and physiologic functions were identified in the CHM mutant cells. We then identified a recombinant adeno-associated virus (AAV serotype, AAV7m8, that is optimal for both delivering transgenes to iPSC-RPEs as well as to appropriate target cells (RPE cells and rod photoreceptors in the primate retina. To establish the proof of concept of AAV7m8 mediated CHM gene therapy, we developed AAV7m8.hCHM, which delivers the human CHM cDNA under control of CMV-enhanced chicken β-actin promoter (CßA. Delivery of AAV7m8.hCHM to CHM iPSC-RPEs restored protein prenylation, trafficking and phagocytosis. The results confirm that AAV-mediated delivery of the REP1-encoding gene can rescue defects in CHM iPSC-RPE regardless of the type of disease-causing mutation. The results also extend our understanding of mechanisms involved in the pathophysiology of choroideremia. Keywords: Choroideremia, Human iPSCs, Retinal pigmented epithelium, Gene therapy, Adeno-associated virus, Phagocytosis, Prenylation, REP1

  8. Deception Operations: Doctrinal Side Show or Operational Imperative?

    Science.gov (United States)

    1989-03-31

    Defense or any of its $enct*s. This 40cUOmt 8m8y n1t be roleaed for open publication UAW It h" bee cleated by Ctb apopriate mitory ente or governenl...vehicles as an everyday occurrence, would be absolutely disoriented at the moment of the Soviet- Mongolian attack. With this objective, systematic daylight...effort for all Soviet forces, that includes special electronic deception units that transmit bogus signals , aimed at deceiving Western reconnaissance

  9. Nuclear power newsletter Vol. 4, no. 2, June 2007

    International Nuclear Information System (INIS)

    2007-06-01

    The topics presented in this newsletter are: International Conference on Non-Electric Application of Nuclear Power; Message from the Director of the Division of Nuclear Power; Nuclear power plant operation; Management systems, nuclear power infrastructures and human resources; Technology developments and applications for advanced reactors; New staff in Nuclear Power Division; Current vacancy notice for professional post in Nuclear Power Division; Upcoming meetings; 2nd International Symposium on PLiM; 8th IAEA-FORATOM Joint Workshop

  10. Avalanche transmission and critical behaviour in load-bearing ...

    Indian Academy of Sciences (India)

    It is well known that many important systems such as the World Wide Web and the Internet, power grids and cellular networks ... iM ) takes the value 1 if a connection exists between iM−1 l and iM and. 0 if a connection ... A network of M = 8 layers with eight sites per layer with connection proba- bility p = 1/2. The beaded line ...

  11. Scientific drilling into the San Andreas Fault Zone

    Science.gov (United States)

    Zoback, Mark; Hickman, Stephen; Ellsworth, William

    2010-01-01

    This year, the world has faced energetic and destructive earthquakes almost every month. In January, an M = 7.0 event rocked Haiti, killing an estimated 230,000 people. In February, an M = 8.8 earthquake and tsunami claimed over 500 lives and caused billions of dollars of damage in Chile. Fatal earthquakes also occurred in Turkey in March and in China and Mexico in April.

  12. Effect of Antioxidant Mixtures on Growth and Ochratoxin A Production of Aspergillus Section Nigri Species under Different Water Activity Conditions on Peanut Meal Extract Agar

    Directory of Open Access Journals (Sweden)

    Carla Barberis

    2010-06-01

    Full Text Available The effect of mixtures of antioxidants butylated hydroxyanisol (BHA and propyl paraben (PP on lag phase, growth rate and ochratoxin A (OTA production by four Aspergillus section Nigri strains was evaluated on peanut meal extract agar (PMEA under different water activities (aw. The antioxidant mixtures used were: BHA + PP (mM, M1 (0.5 + 0.5, M2 (1.0 + 0.5, M3 (2.5 + 0.5, M4 (0.5 + 1.0, M5 (1.0 + 1.0, M6 (2.5 + 1.0, M7 (5.0 + 2.5 and M8 (10 + 2.5. The mixture M8 completely suppressed mycelial growth for all strains. A significant stimulation in OTA production was observed with mixtures M1 to M5 mainly at the highest aw; whereas M6, M7 and M8 completely inhibited OTA production in all strains assayed; except M6 in A. carbonarius strain (RCP G. These results could enable a future intervention strategy to minimize OTA contamination.

  13. A Leader Intron of a Soybean Elongation Factor 1A (eEF1A) Gene Interacts with Proximal Promoter Elements to Regulate Gene Expression in Synthetic Promoters.

    Science.gov (United States)

    Zhang, Ning; McHale, Leah K; Finer, John J

    2016-01-01

    Introns, especially the first intron in the 5' untranslated region (5'UTR), can significantly impact gene expression via intron-mediated enhancement (IME). In this study, we demonstrate the leader intron of a soybean elongation factor 1A (eEF1A) gene (GmScreamM8) was essential for the high activity of the native promoter. Furthermore, the interaction of the GmScreamM8 leader intron with regulatory element sequences from several soybean eEF1A promoters was studied using synthetic promoters, which consisted of element tetramers upstream of a core promoter used to regulate a green fluorescent protein (gfp) reporter gene. Element tetramers, placed upstream of a GmScreamM8 core promoter, showed very high activity using both transient expression in lima bean cotyledons and stable expression in soybean hairy roots, only if the native leader intron was included, suggesting an interaction between intronic sequences and promoter elements. Partial deletions of the leader intron showed that a 222 bp intronic sequence significantly contributed to very high levels of GFP expression. Generation of synthetic intron variants with a monomeric or trimeric repeat of the 222 bp intronic sequence, yielded almost two-fold higher expression compared to the original intron, while partial deletion of the 222 bp intronic repeated sequence significantly decreased gene expression, indicating that this intronic sequence was essential for the intron-element interaction enhancement.

  14. Aspectos eco-epidemiológicos da leishmaniose tegumentar americana no Município de Campinas

    Directory of Open Access Journals (Sweden)

    Corte Antônio Ângelo

    1996-01-01

    Full Text Available Os autores descrevem um surto de leishmaniose tegumentar americana ocorrido no período de fevereiro de 1993 a setembro de 1994, nos Distritos de Sousas e Joaquim Egídio, Município de Campinas, SP. Ocorreram 25 casos, sete na área rural, nove na área peri-urbana e nove na urbana. Verifica-se uma mobilidade da ocorrência dos casos em direção rural-urbana. Em relação ao sexo, houve predomínio do masculino (60% sobre o feminino (40%, com 44% dos casos concentrados na faixa etária de 11 e trinta anos. Quanto à ocupação, 48% correspondem a estudantes, empregadas domésticas e donas-de-casa. Em 92% dos casos, a doença manifestou-se com lesão única, predominantemente localizadas nos membros inferiores e superiores. O surgimento desses casos na área está provavelmente associado à expansão urbana ocorrida nas décadas de 70-80 e acelerada mais recentemente.

  15. EDUCAÇÃO EM SAÚDE COM OS CUIDADORES, CRIANÇAS E ADOLESCENTES DE UM AMBULATÓRIO DE SAÚDE FAMILIAR E COMUNITÁRIA

    Directory of Open Access Journals (Sweden)

    Bruna Cavalheiro Engel

    2016-11-01

    Full Text Available O presente artigo é um relato de experiência do Projeto de Extensão “Humanizar e Educar em Saúde”. O projeto em questão é composto por uma equipe interdisciplinar de docentes e discentes (Fisioterapia, Nutrição e Psicologia, o qual possui como objetivo principal promover a humanização em saúde junto aos cuidadores, adolescentes e crianças na sala de espera do Ambulatório de Saúde Familiar e Comunitária, situado na Universidade do Vale do Itajaí, por meio de diálogos onde estes possam relatar suas vivências, realizando trocas de saberes, através de uma conversa horizontal entre participantes e alunos. Durante o período de intervenção, 48 pacientes foram beneficiados e os encontros mostraram-se efetivos ao considerar a participação dos pacientes e seus cuidadores. As vivências apresentadas demonstram a importância da educação em saúde e da humanização na sala de espera, pois além de propiciar aos participantes novos conhecimentos, estes tornam-se integrante do processo de educação em saúde.

  16. From Stable ZnO and GaN Clusters to Novel Double Bubbles and Frameworks

    Directory of Open Access Journals (Sweden)

    Matthew R. Farrow

    2014-05-01

    Full Text Available A bottom up approach is employed in the design of novel materials: first, gas-phase “double bubble” clusters are constructed from high symmetry, Th, 24 and 96 atom, single bubbles of ZnO and GaN. These are used to construct bulk frameworks. Upon geometry optimization—minimisation of energies and forces computed using density functional theory—the symmetry of the double bubble clusters is reduced to either C1 or C2, and the average bond lengths for the outer bubbles are 1.9 Å, whereas the average bonds for the inner bubble are larger for ZnO than for GaN; 2.0 Å and 1.9 Å, respectively. A careful analysis of the bond distributions reveals that the inter-bubble bonds are bi-modal, and that there is a greater distortion for ZnO. Similar bond distributions are found for the corresponding frameworks. The distortion of the ZnO double bubble is found to be related to the increased flexibility of the outer bubble when composed of ZnO rather than GaN, which is reflected in their bulk moduli. The energetics suggest that (ZnO12@(GaN48 is more stable both in gas phase and bulk frameworks than (ZnO12@(ZnO48 and (GaN12@(GaN48. Formation enthalpies are similar to those found for carbon fullerenes.

  17. Energy evaluation of the Eucalyptus globulus and the Eucalyptus nitens in the north of Spain (Cantabria)

    Energy Technology Data Exchange (ETDEWEB)

    Perez, S.; Renedo, C.J.; Ortiz, A.; Manana, M.; Silio, D. [Electrical and Energy Engineering Department, University of Cantabria, 39005 Santander (Spain)

    2006-12-01

    This work studied the potential use of the waste from Eucalyptus globulus and Eucalyptus nitens as energy crops, evaluating young and adult stages of both in all four seasons of the year with different moisture contents. The study was carried out made in Cantabria (North coast of Spain), located at latitude 43{sup o}28'N, and longitude 3{sup o}48'W. In this region, 29,513ha are dedicated to the growth of Eucalyptus, with about 80% E. globulus, and 20% E. nitens. Six different plantations have been analyzed and their bioclimatic diagrams determined. After the collection of samples the potential energy of every sample was obtained, they were weighed, analyzed and burned, giving a mean net calorific value of 17,384 and 17,927kJ/kg in the adult stage of E. globulus and E. nitens, respectively. The results for the young stage of both species were 17,708 and 18,670kJ/kg. Moisture content in the samples has a great influence on power production. Finally, the economic and environmental consequences of these crop species for the region of Cantabria were analyzed. (author)

  18. The preparation and characterization of Cu(II complexes with N,N’,N”,N’”-tetrakis(2-pyridylmethyl-1,4,8,11-tetraazacyclotetradecane and 2,6-diacetylpyridine bis(semi/thiosemicarbazones

    Directory of Open Access Journals (Sweden)

    GORDANA VUCKOVIC

    2004-03-01

    Full Text Available Two new Cu(II mixed-ligand complexes with octadentate N,N’,N”,N’”-tetrakis(2-pyridylmethyl-1,4,8,11-tetraazacyclotetradecane (tpmc and potentially pentadentate ligands 2,6-diacetylpyridine bis(semicarbazone (DAPsc2 or 2,6-diacetylpyridine bis(thiosemicarbazone (DAPtsc2 were prepared. The general formulas: [Cu4 DAPsc2(tpmc2]ClO48·5CH3COCH3·H2O and [Cu2 DAPtsc2(tpmc](ClO44·7C2H5OH were proposed on the basis of elemental analyses and conductometric measurements. The complexes were characterized by magnetic measurement, electronic absorption and IR spectroscopy. For the dinuclear complex, an exo coordination of Cu(II with four nitrogens from tpmc and m-bonded DAPtsc2 through sulfurs and possibly terminal hydrazinic (azomethine nitrogens is assumed. For the tetranuclear complex, it is supposed that one DAPsc2 bridges two [Cu2 tpmc]4+ units using oxygens and terminal hydrazinic nitrogens as ligators. Finally, some antibacterial activity of the complexes was found.

  19. Localized-itinerant magnetism: a simple model with applications to intermetallic of heavy rare-earths

    International Nuclear Information System (INIS)

    Ranke Perlingueiro, P.J. von.

    1986-01-01

    We have investigated various magnetic quantities of a system consisting of conduction electrons coupled to localized spins. In obtaining the magnetic state equations (which relate the ionic and electronic magnetisations to temperature and the model parameters) we have adopted the molecular field approximation. This simple model is of interest to the magnetism of the heavy rare earth intermettallics. For these systems the localized spin is that of the 4f shell; it is described by the parameters g (the Lande's factor) and J (the total angular momentum of the 4f electrons in the ground state). We derive an analytical linear relation between the critical temperature and The Gennes Factors J(J+1)(g-1) which is experimentally observed for RAl 2 . A fitting between the experimental points and the theoretical prediction gives for the exchange parameter the value J o = 48.6 meV. We have also performed a parametric study of the model, using a rectangular energy density of states. The results are shown on tables and diagrams. (author) [pt

  20. Energy evaluation of the Eucalyptus globulus and the Eucalyptus nitens in the north of Spain (Cantabria)

    International Nuclear Information System (INIS)

    Perez, S.; Renedo, C.J.; Ortiz, A.; Manana, M.; Silio, D.

    2006-01-01

    This work studied the potential use of the waste from Eucalyptus globulus and Eucalyptus nitens as energy crops, evaluating young and adult stages of both in all four seasons of the year with different moisture contents. The study was carried out made in Cantabria (North coast of Spain), located at latitude 43 o 28'N, and longitude 3 o 48'W. In this region, 29,513ha are dedicated to the growth of Eucalyptus, with about 80% E. globulus, and 20% E. nitens. Six different plantations have been analyzed and their bioclimatic diagrams determined. After the collection of samples the potential energy of every sample was obtained, they were weighed, analyzed and burned, giving a mean net calorific value of 17,384 and 17,927kJ/kg in the adult stage of E. globulus and E. nitens, respectively. The results for the young stage of both species were 17,708 and 18,670kJ/kg. Moisture content in the samples has a great influence on power production. Finally, the economic and environmental consequences of these crop species for the region of Cantabria were analyzed. (author)

  1. Sedimentación de pulpas minerales lateríticas en la tecnología de lixiviación ácida a presión: incidencia de la composición mineralógica

    Directory of Open Access Journals (Sweden)

    José Falcón-Hernández

    2007-03-01

    Full Text Available La tecnología de lixiviación ácida a presión que utiliza la industria hidrometalúrgica cubana para la producción de níquel no alcanza a la salida del tanque espesador la concentración de sólidos según lo establecido en el diseño (48 %, lo que repercute negativamente en la economía nacional. Mediante difracción de rayos-x (DRX se determinaron las fases mineralógicas existentes en la mena y con los ensayos de sedimentación se estudió el comportamiento de éstas en las pulpas lateríticas. Se concluye que la presencia de hematita, magnetita y maghemita (fases minerales de metales pesados favorece el proceso de sedimentación de la pulpa mientras que la presencia de fases de metales ligeros como la gibbsita, cuarzo, antigorita y hematita, producen el efecto contrario.

  2. ¿Cuál es el mejor método para estimar variables en yacimientos lateríticos de níquel y cobalto?

    Directory of Open Access Journals (Sweden)

    Niurka Pérez-Melo

    2006-03-01

    Full Text Available Para determinar el método más adecuado de estimar los contenidos de hierro, níquel y cobalto en los yacimientos lateríticos del nordeste de Cuba, se compararon los errores puntuales asociados a varios algoritmos de estimación y simulación, tomando como caso de estudio el bloque O48 del Yacimiento Punta Gorda. La comparación se basó en los resultados de la técnica de jackknife. Los métodos de estimación y simulación lognormal, krigeage con modelo de spline, simulación gaussiana secuencial y simulación condicional por el método de bandas rotantes, esta última con 100 bandas aleatorias. En todos los casos se alcanzaron resultados similares con respecto a la media de los errores, a excepción del krigeage con modelo de spline. La diferencia entre los métodos sólo se hace evidente al comparar las distribuciones de frecuencias de dichos errores. Se demuestra que la exactitud de la estimación, en este caso de estudio, está más influenciada por las características de los datos experimentales y de la estrategia (o elipsoide de búsqueda, que por los métodos de estimación que se empleen.

  3. Probing Deuterium Beyond the Local Bubble: D/N and D/O toward LB 3241 and PG 0952+519

    Science.gov (United States)

    Knauth, D. C.; Andersson, B.-G.; Dupuis, J.; Moos, H. W.

    2003-05-01

    Observations of D/H in the local interstellar medium (Moos et al. 2002) reveal a constant D/H ratio of (1.52 +/- 0.08) x 10-5, however there is a large scatter in the D/H ratio for stars located outside the local bubble (d >= 200pc; Moos et al. 2002; Hoopes et al. 2003). We report on our Far Ultraviolet Spectroscopic Explorer observations of the subdwarfs LB 3241 [(l, b) = (273.o7, -62.o48); d = 610 pc] and PG 0952+519 [(l, b) = (164.o07, +49.o01); d = 530 pc]. Numerous interstellar lines of D 1, O 1, N 1, Fe 2, and P 2 are detected. We present the results of our combined curve-of-growth and profile fitting methods for all species are presented. At distances of 500-600pc these subdwarfs are located well outside the local bubble. Although values of H 1 are unavailable, we present D/N and D/O which enable further constraints to be placed on the variability of D 1 outside the local bubble. This work is based on data obtained for the Guaranteed Time Team by the NASA-CNES-CSA FUSE mission. Financial support has been provided by NASA contract NAS5-32985.

  4. Age as a factor in the responsiveness of the organism to the disruption of cognitive performance by exposure to HZE particles differing in linear energy transfer.

    Science.gov (United States)

    Rabin, Bernard M; Carrihill-Knoll, Kirsty L; Miller, Marshall G; Shukitt-Hale, Barbara

    2018-02-01

    Exposure to particles of high energy and charge (HZE particles) can produce decrements in cognitive performance. A series of experiments exposing rats to different HZE particles was run to evaluate whether the performance decrement was dependent on the age of the subject at the time of irradiation. Fischer 344 rats that were 2-, 11- and 15/16-months of age were exposed to 16 O, 48 Ti, or 4 He particles at the NASA Space Radiation Laboratory at Brookhaven National Laboratory. As previously observed following exposure to 56 Fe particles, exposure to the higher LET 48 Ti particles produced a disruption of cognitive performance at a lower dose in the older subjects compared to the dose needed to disrupt performance in the younger subjects. There were no age related changes in the dose needed to produce a disruption of cognitive performance following exposure to lower LET 16 O or 4 He particles. The threshold for the rats exposed to either 16 O or 4 He particles was similar at all ages. Because the 11- and 15-month old rats are more representative of the age of astronauts (45-55 years old) the present results indicate that particle LET may be a critical factor in estimating the risk of developing a cognitive deficit following exposure to space radiation on exploratory class missions. Copyright © 2017 The Committee on Space Research (COSPAR). All rights reserved.

  5. Ferromagnetism in Gd doped ZnO nanowires: A first principles study

    KAUST Repository

    Aravindh, S. Assa

    2014-12-19

    In several experimental studies, room temperature ferromagnetism in Gd-doped ZnO nanostructures has been achieved. However, the mechanism and the origin of the ferromagnetism remain controversial. We investigate the structural, magnetic, and electronic properties of Zn 48O48 nanowires doped with Gd, using density functional theory. Our findings indicate that substitutionally incorporated Gd atoms prefer occupying the surface Zn sites. Moreover, the formation energy increases with the distance between Gd atoms, signifying that no Gd-Gd segregation occurs in the nanowires within the concentration limit of ≤2%. Gd induces ferromagnetism in ZnO nanowires with magnetic coupling energy up to 21 meV in the neutral state, which increases with additional electron and O vacancy, revealing the role of carriers in magnetic exchange. The potential for achieving room temperature ferromagnetism and high TC in ZnO:Gd nanowires is evident from the large ferromagnetic coupling energy (200 meV) obtained with the O vacancy. Density of states shows that Fermi level overlaps with Gd f states with the introduction of O vacancy, indicating the possibility of s-f coupling. These results will assist in understanding experimental findings in Gd-doped ZnO nanowires.

  6. HIGH PERCENTAGE OF RARE EARTH ELEMENT CONNECTION WITH THE ACCUMULATION SEDIMENT AS RESPONSE LONGSHORE CURRENTS IN THE BELITUNG WATERS

    Directory of Open Access Journals (Sweden)

    Delyuzar Ilahude

    2017-07-01

    Full Text Available The study area is geographically located in the West coast of Belitung island at coordinates 105o48'00" - 106o06' 00" E and 06o46'00" - 06o50' 00" S. The beach and coastal area is influenced by wave energy from the West and North directions The purpose of this study is to analyze the relationship between the zone of sediment accumulation of empirical approaches on oceanography parameter containing rare earth elements. The approach used is to predict the shore wave energy using wave prediction curve deep waters to obtain the energy flux of the wave at each point of reference. Sediments containing rare earth elements tend to lead to the south as a result of the movement of longshore currents. Regional coastal area of the western part of the island of Belitung, especially in the southern part of the estuary of the river Tanjung Pandan is estimated to be a zone of sediment accumulation. The movement of sediment caused by wave energy from the north led to sedimentation evolved significantly in the south which is thought to contain rare earths minerals derived from land. This sedimentation process takes place on a seasonal basis, which allegedly took place in the west. The movement of sediment to the south of the mouth of the Cerucuk River it is predicted that rare earth elements were supplied from these rivers tend to settle in the southern part of the estuary Cerucuk throughout the year.

  7. Li3Al(MoO4)3, a lyonsite molybdate.

    Science.gov (United States)

    Bugaris, Daniel E; zur Loye, Hans-Conrad

    2012-06-01

    Trilithium aluminium trimolybdate(VI), Li(3)Al(MoO(4))(3), has been grown as single crystals from α-Al(2)O(3) and MoO(3) in an Li(2)MoO(4) flux at 998 K. This compound is an example of the well known lyonsite structure type, the general formula of which can be written as A(16)B(12)O(48). Because this structure can accomodate cationic mixing as well as cationic vacancies, a wide range of chemical compositions can adopt this structure type. This has led to instances in the literature where membership in the lyonsite family has been overlooked when assigning the structure type to novel compounds. In the title compound, there are two octahedral sites with substitutional disorder between Li(+) and Al(3+), as well as a trigonal prismatic site fully occupied by Li(+). The (Li,Al)O(6) octahedra and LiO(6) trigonal prisms are linked to form hexagonal tunnels along the [100] axis. These polyhedra are connected by isolated MoO(4) tetrahedra. Infinite chains of face-sharing (Li,Al)O(6) octahedra extend through the centers of the tunnels. A mixed Li/Al site, an Li, an Mo, and two O atoms are located on mirror planes.

  8. Stable solidification of cesium with an allophane additive by a pressing/sintering method

    Science.gov (United States)

    Zhang, Xiaoxia; Wu, Yan; Wei, Yuezhou; Mimura, Hitoshi; Matsukura, Minoru

    2017-03-01

    Pyrolysis of AMP/SiO2 adsorbed Cs (AMP-Cs/SiO2) occurred at > 400 °C sintering temperature, and Cs immobilisation decreased from 100% to 40% after sintering at 1200 °C. To safely dispose radioactive Cs, allophane was immobilized with AMP-Cs/SiO2 to prepare a stable form by using a pressing/sintering method. The structure of AMP-Cs/SiO2 collapsed, and cesium aluminosilicate formed more easily under conditions of higher sintering temperature (>800 °C) or increasing mixing ratio of allophane (mass ratio = 1:3 AMP-Cs/SiO2-allophane). The decomposition products of AMP-Cs/SiO2 were Cs2O, MoO3 and P2O5 at 1200 °C. Cs2O volatilisation was depressed by allophane addition, and a stable immobilisation phase of Cs4Al4Si20O48 formed. An immobilisation ratio of Cs of approximately 100% was maintained. The leachability of Cs for AMP-Cs/SiO2-allophane (1:3, 1200 °C) in distilled water at 25 °C and 90 °C for 15 days was estimated as 0.174% and 1.55%, respectively.

  9. EVALUATION OF COMPLICATOINS AND BENEFITS OF HISTOACRYL TISSUE GLUE IN SURGICAL WOUNDS

    Directory of Open Access Journals (Sweden)

    M. R. Zafarghandy

    1999-07-01

    Full Text Available - Healing of surgical wounds and their complications such as infection or scar formation are of major concern in surgery. Tissue glues are advanced to reduce these problems. In a prospective study, we have evaluated surgical wound healing in 76 patients whose surgical wounds were repaired by tissue glues (Histoacryl. This study was performed in four leaching hospitals (Sina, Shariaty, Shohada, Razi. The major parameters co/isidered for this study were complete wound healing in the first postoperative week, early wound complications, late wound complications, and their relation with some other factors such as wound size and glue application techniques. In our study, complete wound healing in less than one week was seen in 81.9% of patients, whereas 18.1% had a longer course. Early complications consisted of (5.6% infection and (2.8% hematoma. Late complications included hypertrophy (O.48% and widening (18.1% of scars. Tliere was a significant correlation between wound size and healing time (P<0.05, but not between faulty techniques and scar formation. 

  10. Statistical Properties of Blue Horizontal Branch Stars in the Spheroid: Detection of a Moving Group approximately 50 kpc from the Sun

    Energy Technology Data Exchange (ETDEWEB)

    Harrigan, Matthew J.; Newberg, Heidi Jo; Newberg, Lee A.; /Rensselaer Poly.; Yanny, Brian; /Fermilab; Beers, Timothy C.; Lee, Young Sun; /Michigan State U.; Fiorentin, Paola Re; /Ljubljana U. /Heidelberg, Max Planck Inst. Astron.

    2010-02-01

    A new moving group comprising at least four Blue Horizontal Branch (BHB) stars is identified at (l; b) = (65{sup o}; 48{sup o}). The horizontal branch at g{sub 0} = 18.9 magnitude implies a distance of 50 kpc from the Sun. The heliocentric radial velocity is = -157 {+-} 4 km s{sup -1}, corresponding to V{sub gsr} = -10 km s{sup -1}; the dispersion in line-of-sight velocity is consistent with the instrumental errors for these stars. The mean metallicity of the moving group is [Fe/H] {approx} -2.4, which is significantly more metal poor than the stellar spheroid. We estimate that the BHB stars in the outer halo have a mean metallicity of [Fe/H]=-2.0, with a wide scatter and a distribution that does not change much as a function of distance from the Sun. We explore the systematics of SDSS DR7 surface gravity metallicity determinations for faint BHB stars, and present a technique for estimating the significance of clumps discovered in multidimensional data. This moving group cannot be distinguished in density, and highlights the need to collect many more spectra of Galactic stars to unravel the merger history of the Galaxy.

  11. Age as a factor in the responsiveness of the organism to the disruption of cognitive performance by exposure to HZE particles differing in linear energy transfer

    Science.gov (United States)

    Rabin, Bernard M.; Carrihill-Knoll, Kirsty L.; Miller, Marshall G.; Shukitt-Hale, Barbara

    2018-02-01

    Exposure to particles of high energy and charge (HZE particles) can produce decrements in cognitive performance. A series of experiments exposing rats to different HZE particles was run to evaluate whether the performance decrement was dependent on the age of the subject at the time of irradiation. Fischer 344 rats that were 2-, 11- and 15/16-months of age were exposed to 16O, 48Ti, or 4He particles at the NASA Space Radiation Laboratory at Brookhaven National Laboratory. As previously observed following exposure to 56Fe particles, exposure to the higher LET 48Ti particles produced a disruption of cognitive performance at a lower dose in the older subjects compared to the dose needed to disrupt performance in the younger subjects. There were no age related changes in the dose needed to produce a disruption of cognitive performance following exposure to lower LET 16O or 4He particles. The threshold for the rats exposed to either 16O or 4He particles was similar at all ages. Because the 11- and 15-month old rats are more representative of the age of astronauts (45-55 years old) the present results indicate that particle LET may be a critical factor in estimating the risk of developing a cognitive deficit following exposure to space radiation on exploratory class missions.

  12. Seismicity of the Earth 1900-2010 Aleutian arc and vicinity

    Science.gov (United States)

    Benz, Harley M.; Herman, Matthew; Tarr, Arthur C.; Hayes, Gavin P.; Furlong, Kevin P.; Villaseñor, Antonio; Dart, Richard L.; Rhea, Susan

    2011-01-01

    This map shows details of the Aleutian arc not visible in an earlier publication. The Aleutian arc extends about 3,000 km from the Gulf of Alaska to the Kamchatka Peninsula. It marks the region where the Pacific plate subducts into the mantle beneath the North America plate. This subduction is responsible for the generation of the Aleutian Islands and the deep offshore Aleutian Trench. Relative to a fixed North America plate, the Pacific plate is moving northwest at a rate that increases from about 55 mm per year at the arc's eastern edge to 75 mm per year near its western terminus. In the east, the convergence of the plates is nearly perpendicular to the plate boundary. However, because of the boundary's curvature, as one travels westward along the arc, the subduction becomes more and more oblique to the boundary until the relative plate motion becomes parallel to the arc at the Near Islands near its western edge. Subduction zones such as the Aleutian arc are geologically complex and produce numerous earthquakes from multiple sources. Deformation of the overriding North America plate generates shallow crustal earthquakes, whereas slip at the interface of the plates generates interplate earthquakes that extend from near the base of the trench to depths of 40 to 60 km. At greater depths, Aleutian arc earthquakes occur within the subducting Pacific plate and can reach depths of 300 km. Since 1900, six great earthquakes have occurred along the Aleutian Trench, Alaska Peninsula, and Gulf of Alaska: M8.4 1906 Rat Islands; M8.6 1938 Shumagin Islands; M8.6 1946 Unimak Island; M8.6 1957 Andreanof Islands; M9.2 1964 Prince William Sound; and M8.7 1965 Rat Islands. Several relevant tectonic elements (plate boundaries and active volcanoes) provide a context for the seismicity presented on the main map panel. The plate boundaries are most accurate along the axis of the Aleutian Trench and more diffuse or speculative in extreme northeastern Russia. The active volcanoes parallel

  13. Recto-sigmoid polypectomy by a handmade snare: Experience of 24 children with bleeding per rectum

    Directory of Open Access Journals (Sweden)

    Manoj Saha

    2014-01-01

    Full Text Available A handmade snare is designed from easily available materials to treat bleeding per rectum in children due to rectosigmoid polyps. A total of 29 polypectomies were done in 24 patients. It is simple, effective, safe and economic.

  14. 24 CFR 982.552 - PHA denial or termination of assistance for family.

    Science.gov (United States)

    2010-04-01

    ... institution of higher education as specified in 24 CFR 5.612. (c) Authority to deny admission or terminate... family has committed fraud, bribery, or any other corrupt or criminal act in connection with any Federal...

  15. The Electro-Encephalogram in Phenylketonuria

    Science.gov (United States)

    Todd, Peter G.; Pitt, D. B.

    1973-01-01

    Evaluated were electroencephalographic findings in 24 untreated (ages from 4 to 38 years) patients suffereing from phenylketonuria (a metabolic disorder producing severe mental retardation if not treated with proper diet during the early years). (DB)

  16. Concentrations of prioritized pharmaceuticals in effluents from 50 large wastewater treatment plants in the US and implications for risk estimation

    Science.gov (United States)

    We measured the concentrations of 56 active pharmaceutical ingredients (APIs) and seven metabolites, including 50 prioritized APIs, in 24-hour composite effluent samples collected from 50 very large municipal wastewater treatment plants across the US. Hydrochlorothiazide was foun...

  17. The Presidential Sweepstakes 2004

    Science.gov (United States)

    Doyle, Denis P.

    2004-01-01

    For the sixth time in 24 years, Mr. Doyle, the author of this article, has enabled the Kappan to publish the education programs of the major Presidential candidates. In this article, he shares with readers his views on Campaign 2004.

  18. Electrocatalysis in fuel cells a non- and low- platinum approach

    CERN Document Server

    Shao, Minhua

    2014-01-01

    In 24 chapters written by worldwide experts, this book details the fundamentals and applications of novel electrocatalysts, and summarizes recent advances in oxygen reduction and alcohol oxidation, with a particular focus on non- and low-Pt electrocatalysts.

  19. Surface Facial Electromyography Reactions to Light-Relevant and Season-Relevant Stimuli in Seasonal Affective Disorder

    National Research Council Canada - National Science Library

    Lindsey, Kathryn T

    2005-01-01

    Facial electromyography (EMG) activity was recorded from the zygomaticus major and corrugator supercilii muscle regions to examine emotion-specific reactivity in 24 currently depressed individuals meeting DSM-IV criteria...

  20. Analgesic efficacy of low-dose intrathecal neostigmine in combination with fentanyl and bupivacaine for total knee replacement surgery

    Directory of Open Access Journals (Sweden)

    Amit Jain

    2012-01-01

    Conclusions: The addition of 1 mcg neostigmine IT increased the duration of analgesia and decreased the analgesic consumption in 24 h in TKR. There was no increase in the incidence of adverse effects.

  1. [Clinical application of protein-to-creatinine ratio in spot urine samples for preeclampsia].

    Science.gov (United States)

    Kuang, Lin; Liang, Feng-bing; Yang, Cui-yu

    2012-08-07

    To evaluate the clinical application of protein-to-creatinine ratio (P/Cr) in spot urine samples so as to check whether it can replace urine protein excretion in 24 h collections for the diagnosis and screening of preeclampsia. The investigators selected 100 cases of pregnant women with preeclampsia and 36 cases of normal pregnant women examined at Sir Run Run Shaw Hospital over the last two years. The correlations between P/Cr in first morning urine samples and urinary protein excretion in 24 h collections were analyzed. The cutoff values of P/Cr in first morning urine samples for screening preeclampsia of 0.3 g and 5 g in urinary protein excretion in 24 h collections were determined by a receiver operating characteristics (ROC) curve. A highly significant correlation existed between P/Cr in first morning urine samples and urinary protein excretion in 24 h collections. By the ROC curve analysis, the P/Cr of 0.34 g/g and 2.08 g/g in first morning urine samples represented the most appropriate threshold for detecting the urinary protein excretion of 0.3 g and 5 g in 24 h collections. The P/Cr in spot urine samples can replace urinary protein excretion in 24 h collections. It is a simple and reliable tool of diagnosis and follow-up for preeclampsia.

  2. Study of warm ischemia followed by reperfusion on a lower limb model in rats: effect of allopurinol and streptokinase Estudo da isquemia quente e reperfusão em membro inferior de ratos: efeito do allopurinol e estreptokinase

    Directory of Open Access Journals (Sweden)

    Marcelo Sacramento Cunha

    2005-06-01

    Full Text Available Prolonged tissue ischemia leads to changes in microcirculation and production of oxygen free radicals. The event eventually responsible for tissue death is the no-reflow phenomenon and its management is a challenge for the surgeon dealing with replantation or transplantation. We introduce a model of warm ischemia and reperfusion of the lower limb of rats with which we studied the effect of allopurinol and streptokinase. METHOD: Section of the lower limb with preservation of vessels and nerves was performed in 110 rats. Femoral vessels clamped for periods of 0, 2, 4, 6, and 8 hours of ischemia were allowed to reperfuse (groups M0, M2, M4, M6, and M8 respectively. Other groups, E1, E2, and E3, received streptokinase, allopurinol, or a combination of the two drugs after 6 hours of ischemia. RESULTS: Viability rates of the ischemic limbs after 7 days were 100% (M0, 80% (M2, 63.6% (M4, 50% (M6, and 20% (M8. In the experimental groups, E1, E2, and E3, viability rates were 67% (E1, 70% (E2, and 70% (E3. Groups M0, M2, M4, M6, and M8 differed among themselves except for groups M4 and M6. Group E1 had a higher rate of limb viability than M6 (control group but not than M4. Groups E1, E2 and E3 had higher rates of limb viability than M6 but not than M2 or M4. DISCUSSION: The results suggest that increased viability of limbs after 6 hours of ischemia occurs when allopurinol or streptokinase is used. The combination of the two drugs does not appear to produce any additional effect.A isquemia prolongada dos tecidos leva a alterações na microcirculação e liberação de radicais livres do oxigênio, evento que pode resultar na morte do tecido, conhecido como fenômeno de não reperfusão. Um modelo em ratos de isquemia quente e reperfusão do membro posterior é proposto, e os efeitos dos fármacos alopurinol e estreptoquinase foram estudados. MÉTODO: Secção do membro posterior com preservação dos vasos e nervos foi realizada em 110 ratos. O pin

  3. Widespread distribution of CTX-M and plasmid-mediated AmpC β-lactamases in Escherichia coli from Brazilian chicken meat

    Directory of Open Access Journals (Sweden)

    Larissa Alvarenga Batista Botelho

    2015-04-01

    Full Text Available The dissemination of plasmid-mediated antimicrobial resistance genes may pose a substantial public health risk. In the present work, the occurrences of blaCTX-M and plasmid-mediated ampC and qnr genes were investigated in Escherichia coli from 16 chicken carcasses produced by four commercial brands in Brazil. Of the brands tested, three were exporters, including one of organic chicken. Our study assessed 136 E. coli isolates that were grouped into 77 distinct biotypes defined by their origin, resistance profiling, the presence of β-lactamase and plasmid-mediated quinolone resistance genes and enterobacterial repetitive intergenic consensus-polimerase chain reaction typing. The blaCTX-M-15, blaCTX-M-2 and blaCTX-M-8 genes were detected in one, 17 and eight different biotypes, respectively (45 isolates. Twenty-one biotypes (46 isolates harboured blaCMY-2. Additionally, blaCMY-2 was identified in isolates that also carried either blaCTX-M-2 or blaCTX-M-8. The qnrB and/or qnrS genes occurred in isolates carrying each of the four types of β-lactamase determinants detected and also in oxyimino-cephalosporin-susceptible strains. Plasmid-mediated extended-spectrum β-lactamase (ESBL and AmpC determinants were identified in carcasses from the four brands tested. Notably, this is the first description of blaCTX-M-15 genes in meat or food-producing animals from South America. The blaCTX-M-8, blaCTX-M-15 and blaCMY-2 genes were transferable in conjugation experiments. The findings of the present study indicate that plasmid-mediated ESBL and AmpC-encoding genes are widely distributed in Brazilian chicken meat.

  4. Case Study: Unfavorable But Transient Physiological Changes During Contest Preparation in a Drug-Free Male Bodybuilder.

    Science.gov (United States)

    Pardue, Andrew; Trexler, Eric T; Sprod, Lisa K

    2017-12-01

    Extreme body composition demands of competitive bodybuilding have been associated with unfavorable physiological changes, including alterations in metabolic rate and endocrine profile. The current case study evaluated the effects of contest preparation (8 months), followed by recovery (5 months), on a competitive drug-free male bodybuilder over 13 months (M1-M13). Serum testosterone, triiodothyronine (T 3 ), thyroxine (T 4 ), cortisol, leptin, and ghrelin were measured throughout the study. Body composition (BodPod, dualenergy x-ray absorptiometry [DXA]), anaerobic power (Wingate test), and resting metabolic rate (RMR) were assessed monthly. Sleep was assessed monthly via the Pittsburgh Sleep Quality Index (PSQI) and actigraphy. From M1 to M8, testosterone (623-173 ng∙dL -1 ), T 3 (123-40 ng∙dL -1 ), and T 4 (5.8-4.1 mg∙dL -1 ) decreased, while cortisol (25.2-26.5 mg∙dL -1 ) and ghrelin (383-822 pg∙mL -1 ) increased. The participant lost 9.1 kg before competition as typical energy intake dropped from 3,860 to 1,724 kcal∙day -1 ; BodPod estimates of body fat percentage were 13.4% at M1, 9.6% at M8, and 14.9% at M13; DXA estimates were 13.8%, 5.1%, and 13.8%, respectively. Peak anaerobic power (753.0 to 536.5 Watts) and RMR (107.2% of predicted to 81.2% of predicted) also decreased throughout preparation. Subjective sleep quality decreased from M1 to M8, but objective measures indicated minimal change. By M13, physiological changes were largely, but not entirely, reversed. Contest preparation may yield transient, unfavorable changes in endocrine profile, power output, RMR, and subjective sleep outcomes. Research with larger samples must identify strategies that minimize unfavorable adaptations and facilitate recovery following competition.

  5. [Study on the phase II metabolites of phenoprolamine hydrochloride in rat bile by LC/DAD/MSD].

    Science.gov (United States)

    Ding, L; Zhang, Z X; Ni, P Z; Wang, G J; An, D K

    2001-06-01

    To study the phase II metabolites of phenoprolamine hydrochloride (DDPH) in rat bile. DDPH was administered by i.p. to bile duct-cannulated rats. Bile samples were collected before drug administration and up to 12 h after drug administration. After being purified and enriched with C-18 SPE columns the rat bile samples were analyzed by LC/DAD/MSD to identify the peaks of phase II metabolites. The fractions of phase II metabolites were prepared by HPLC and treated with beta-glucuronidase, and then were purified and enriched with C-18 SPE columns and analyzed by LC/DAD/MSD. The corresponding reference standards of DDPH phase I metabolites were analyzed by LC/DAD/MSD under identical conditions. The peaks M7, M8 and M9 in the chromatograms of rat bile samples were the phase II metabolites of DDPH and the enzymatic hydrolysates of M7, M8 and M9 were 1-(2, 6-dimethyl-4-hydroxyphenoxy)-2-(3, 4-methoxyphenylethylamino)-propane (M3), 1-(2, 6-dimethyl-3-hydroxyphenoxy)-2-(3, 4-methoxyphenylethylamino)-propane (M2) and 1-(2,6-dimethylphenoxy)-2-(3-methoxy-4-hydroxyphenylethyl-amino)-propane (M1) respectively. beta-1-O-[3,5-dimethyl-4-[-2-methyl-2-(3,4-dimethoxy-phenylethylamino)- ethoxy]-phenyl]-glucuronic acid (M7, glucuronide of M3), beta-1-O-[2, 4-dimethyl-3-[2-methyl-2-(3, 4-dimethoxy-phenylethylamino)-ethoxy]-phenyl]-glucuronic acid (M8, glucuronide of M2) and beta-1-O-[2-methoxy-4-[1-methyl-2-(2, 6-dimethylphenoxy)-ethylamino-ethyl]-phenyl]-glucuronic acid (M9, glucuronide of M1) were the phase II metabolites of DDPH in rat bile.

  6. Widespread distribution of CTX-M and plasmid-mediated AmpC β-lactamases in Escherichia coli from Brazilian chicken meat.

    Science.gov (United States)

    Botelho, Larissa Alvarenga Batista; Kraychete, Gabriela Bergiante; Costa e Silva, Jacqueline Lapa; Regis, Douglas Viller Vieira; Picão, Renata Cristina; Moreira, Beatriz Meurer; Bonelli, Raquel Regina

    2015-04-01

    The dissemination of plasmid-mediated antimicrobial resistance genes may pose a substantial public health risk. In the present work, the occurrences of blaCTX-M and plasmid-mediated ampC and qnr genes were investigated in Escherichia coli from 16 chicken carcasses produced by four commercial brands in Brazil. Of the brands tested, three were exporters, including one of organic chicken. Our study assessed 136 E. coli isolates that were grouped into 77 distinct biotypes defined by their origin, resistance profiling, the presence of β-lactamase and plasmid-mediated quinolone resistance genes and enterobacterial repetitive intergenic consensus-polimerase chain reaction typing. The blaCTX-M-15, blaCTX-M-2 and blaCTX-M-8 genes were detected in one, 17 and eight different biotypes, respectively (45 isolates). Twenty-one biotypes (46 isolates) harboured blaCMY-2. Additionally, blaCMY-2 was identified in isolates that also carried either blaCTX-M-2 or blaCTX-M-8. The qnrB and/or qnrS genes occurred in isolates carrying each of the four types of β-lactamase determinants detected and also in oxyimino-cephalosporin-susceptible strains. Plasmid-mediated extended-spectrum β-lactamase (ESBL) and AmpC determinants were identified in carcasses from the four brands tested. Notably, this is the first description of blaCTX-M-15 genes in meat or food-producing animals from South America. The blaCTX-M-8, blaCTX-M-15 and blaCMY-2 genes were transferable in conjugation experiments. The findings of the present study indicate that plasmid-mediated ESBL and AmpC-encoding genes are widely distributed in Brazilian chicken meat.

  7. Wide aperture multipole magnets of the kinematic separator COMBAS. Correcting pair of multipole magnets M3M4 (M5M6) with compensation for higher order aberrations

    International Nuclear Information System (INIS)

    Artyukh, A.G.; Gridnev, G.F.; Teterev, Yu.G.

    1999-01-01

    The high-resolving large aperture separator COMBAS has been created and commissioned. The magneto-optical structure of the separator is based on the strong focusing principle. The separator consists of eight wide aperture multipole magnets M1-M8. The magnets M1, M2, M7, M8 forming the 1 st order optics together with some higher order optical corrections and M3-M6 being dedicated to higher order corrections of the chromatic and spherical aberrations at the intermediate and exit foci of the separator. The multipole correctors M3-M6 contain the dipolar, sextupole and octupole components in their magnetic field distributions. It was the use of the rectangular dipoles M3-M6 as carriers of sextupole and octupole field components that let achieve high values of the separator angular and momentum acceptances. Measurements of the magnetic field distributions in the median planes of the pairs of magnets M3M6 (M4M5) have been performed. These measurements allowed one to analyze the magnets manufacturing quality. Based on the analysis, shimming of pole pieces of the pair of magnets M3M6 have been done. Pole surface correcting coils for the magnets M4M5 have been foreseen to compensate for small deviations (within a few percents) of the 2 nd and 3 rd order field components from the design values, which are probable due to manufacturing errors in all the magnets M1-M8. The measured magnetic field distributions are supposed to be used for particle trajectory simulations throughout the entire separator

  8. Gambling score in earthquake prediction analysis

    Science.gov (United States)

    Molchan, G.; Romashkova, L.

    2011-03-01

    The number of successes and the space-time alarm rate are commonly used to characterize the strength of an earthquake prediction method and the significance of prediction results. It has been recently suggested to use a new characteristic to evaluate the forecaster's skill, the gambling score (GS), which incorporates the difficulty of guessing each target event by using different weights for different alarms. We expand parametrization of the GS and use the M8 prediction algorithm to illustrate difficulties of the new approach in the analysis of the prediction significance. We show that the level of significance strongly depends (1) on the choice of alarm weights, (2) on the partitioning of the entire alarm volume into component parts and (3) on the accuracy of the spatial rate measure of target events. These tools are at the disposal of the researcher and can affect the significance estimate. Formally, all reasonable GSs discussed here corroborate that the M8 method is non-trivial in the prediction of 8.0 ≤M < 8.5 events because the point estimates of the significance are in the range 0.5-5 per cent. However, the conservative estimate 3.7 per cent based on the number of successes seems preferable owing to two circumstances: (1) it is based on relative values of the spatial rate and hence is more stable and (2) the statistic of successes enables us to construct analytically an upper estimate of the significance taking into account the uncertainty of the spatial rate measure.

  9. Prevalence and factors associated with unmet need for family planning among the currently married reproductive age women in Shire-Enda- Slassie, Northern West of Tigray, Ethiopia 2015: a community based cross-sectional study.

    Science.gov (United States)

    Gebre, Gelawdiwos; Birhan, Nigussie; Gebreslasie, Kahsay

    2016-01-01

    Unmet family planning is one of the common causes for low contraceptive prevalence rate in developing countries including Ethiopia. Thus, this study designed to assess the prevalence and associated factors of unmet need in Shire Endaslassie town, Northern west of Tigray, Ethiopia. A community based cross sectional study design was employed. Multistage sampling technique was employed and data were collected using a semi-structured questionnaire by interviewer administered technique. Questionnaires were reviewed and checked for completeness, accuracy and consistency. Reviewed data were entered to Epi info 7 and analyzed by SPSS version 20 statistical software. Variables with P-value of less than 0.2 in bivariate analyses were entered for multivariate analysis and AOR at 95% CI with p-value of less than 0.05 were considered as significant variables. The overall unmet need for family planning in the study area was 109(21.4%). 74(14.5%) for spacing and 35(6.9%) for limiting. Age group of 35-39 and >=40 (AOR= 2.7,95%CI:1.1,6.5), (AOR = 2.65, 95%CI:1.10, 6.40) respectively, decided numbers of desired children more than five (AOR = O.48, 95%CI: 0.28, 0.80), discussions of client with heath care providers (AOR = 6.32, 95%CI: 2.56, 15.58), previous use of modern family planning (AOR = 2.29, 95%CI, 1.20, 4.34) were significantly associated with unmet need for family planning. Unmet need for family planning in the study area was high, so continuous discussion on modern family planning with community health workers and encouraging of women to decide desired numbers of children of less than five in general are better to be strengthened.

  10. Long term follow up of medical therapy of thyroid cancer; Controle a long terme du traitement medical du cancer thyroidien differencie

    Energy Technology Data Exchange (ETDEWEB)

    Jaffiol, C.; Daures, J.P.; Nsakala, N.; Guerenova, J.; Baldet, L.; Pujol, P.; Vannereau, D.; Bringer, J. [Centre Hospitalier Universitaire, 34 - Montpellier (France)

    1995-12-31

    106 patients, 114 W, 27 M, were thyroidectomized for differentiated thyroid cancer (follicular 29.3% - papillary 54.3%) with different stages of gravity (N O: 48.2% - N 1: 32.8% - N 2: 19%). Neck dissection was used in cases of involved nodes. One or several doses of 131 I were given to 126 subjects, 106 patients were treated with L thyroxine (LT4) (mean daily dose: 2.5 {mu}g/kg BW). 23 patients presenting intolerance to LT4 with non suppressed TSH for 13 of them were treated by an association of tiratricol (TRIAC) + LT4. The follow up included a yearly check up involving clinical examination, plasma thyroglobulin (Tg) and thyroid stimulating hormone (TSH) assessment, neck ultrasonography and X ray of the chest. Therapy was stopped for 4 weeks in cases with Tg above its detectable value and a total body scan performed with Tg and TSH controls. The mean duration of follow up was 94.5 {+-} 67.7 months and extended to more than 5 years for 61% of the patients. We observed 22 relapses of the tumor with 4 deaths. Age less then 45 years, appears as the best factor of prognosis. 2 groups of patients were compared to evaluate the incidence of TSH suppression on the relapse free survival (group 1 n = 30 with a TSH {<=} 0.10 mU/1 and group 2 n = 15 with a TSH always > 1 mU/1 during the follow up). The relapse free survival was shorter in group 2 (p 0.01). Association of TRIAC with LT4 leads to a reduction of the daily dose of LT4 (m 25{mu}g/day) with a significant improvement of TSH suppression and clinical tolerance. In conclusion, TSH suppression improves the prognosis in thyroidectomized patients for differentiated carcinoma. Association of TRIAC with LT4 seems able to approve TSH suppression and therapeutic tolerance. (authors). 40 refs., 5 tabs.

  11. Barriers professional competence and its relationship with job satisfaction of nurses' moral distress and pre-hospital emergency city of Bam and Jiroft in 1393

    Directory of Open Access Journals (Sweden)

    Mohammadjavad Rahimzadeh

    2016-05-01

    Full Text Available In order to "protect the health of people" Several organizations have been founded and given its role in saving lives when seconds play, is formed Medical Center Emergency Management Whose duty is satisfactory service in the shortest possible time. Because one of the pre-hospital emergency center nurses work centers and first deal with critical diseases carried by nurses, so they are faced with numerous obstacles which could impact on their job satisfaction has less moral distress. In this study, efficient professional barriers and its relation to moral distress and job satisfaction are studied prehospital emergency nurses. This study is a descriptive - correlation of prehospital emergency personnel Bam on 82 Jiroft who were selected by census was conducted. Data gathering questionnaire, including demographic characteristics, barriers to efficient professional, moral distress, job satisfaction after obtaining the appropriate reliability and validity were used. Analysis of the data in this study using SPSS version 18, using measures of central tendency and dispersion, t-test, Pearson correlation coefficient, ANOVA and regression analysis were used. According to the non-normal distribution efficiency and moral distress two variables obstacles relationship between these two variables with Spearman nonparametric Kruskal-Wallis test other variables and for other variables that were normally distributed parametric tests and ANOVA were used Pearson correlation coefficient. A total of 82 patients with mean age (31.54± 5.66 participated in th e study showed. Results are73.4% married, work experience, most people (% 91.5 were under 15 years old. Most people (52% with traffic and pedestrians as factors impeding efficient professional, fully agreed, the average score of moral distress (o.48 ± 2.13, the level of moral distress was most mid-level and job satisfaction 52. 4% of them were average. The results showed that between moral distress and job

  12. Study of 16O-induced deep inelastic nuclear reactions on 27Al, 48Ti, and 58Ni by spectroscopy of the gamma radiation from the reaction products

    International Nuclear Information System (INIS)

    Puchta, H.

    1980-01-01

    The present thesis deals with the spectroscopy of the gamma radiation from the reaction fragments after binary reactions in the systems 16 O + 27 Al, 48 Ti, and 58 Ni at incident energies from 90 to 100 MeV, i.e. far above the Coulomb threshold. ΔE-E telescopes, which were located at 35 0 to the beam direction, detected the projectile-like fragments and defined the reaction channel and the scattering plane. In coincidence to this the gamma quanta in a 120-cm 3 -Ge(Li)-diode and a 27 x 33-cm-NaI-spectrometer were observed. The gamma spectra are equal to those observed hitherto in fusion reactions except for the high energetic gamma lines from the ejectiles, which are raised from the gamma continuum of the heavy fragments. From the spectroscoped gamma radiation for the light as for the heavy fragments the excitation energy, the value of the fragment angular momentum, as well as the occupation of the magnetic sublevels could be determined. The hard projectile 16 O transfers the dissipated energy and the angular momentum transferred by the spin of the fragments nearly completely into the residue nucleus. The probability for the observation of a ground state transition in one of the heavy fragments extends to (0.85 +- 0.10) per carbon ejectile in the system 16 O + 48 Ti. The residue nucleus distribution corresponds to that expected by the statistical model from the decay of the compound-nucleus 52 Cr belonging to the ejectile 12 C, the excitation energy of which corresponds to the reaction Q-value. (orig./HSI) [de

  13. Geotectonic significance of the Marayes Viejo basalt based on K-Ar age dating; Western Pampean Ranges, San Juan Province, Argentina

    International Nuclear Information System (INIS)

    Castro de Machuca, B.; Sumay, C; Bruno, N; Meissl, E; Conte-Grand, A

    2001-01-01

    Beginning in the lower Triassic, intracratonic, basins are formed in the Westem Pampean Ranges region, San Juan province, Argentina. One of these basins, the Marayes-El Carrizal basin, extends in an approximate NNW-SSE direction along the entire western edge of the La Huerta range, between latitudes 31 o 15' - 31 o 48' South and longitudes 67 o 12'-67 o 3O' West. According to Ramos (1993), the initial facies of the synrift deposits (Marayes Group) that fill the mentioned basin, are associated with the emplacement of basaltic flows and sills, part of the residual activity of the Choiyoi Group. Bossi (1975), analyzes in detail the stratigraphy of the Marayes Group. lt consists of an interstratified sequence of continental clastic sediments of mid to upper Triassic age (based on paleontological and palinological evidences) including, in ascending stratigraphic order, the Esquina Colorada, Carrizal and Quebrada del Barro Formations. The only igneous component in this sequence is a basaltic body, referred to as Marayes Viejo Basalt (BMV), located in the area known as Marayes Viejo in the extreme southem part of the La Huerta range, at approximately 31 o 25' South Latitude and 67 o 22' West Longitude. He describes the body as an 'elongated oval shaped dike that intrudes the Esquina Colorada Formation and whose age is uncertain because is an intrusive body'. More recently, Castro de Machuca et al. (1998), identify in the same area a small hypabisal body of andesitic composition, the Marayes Viejo Porphry (PNW), whose radiometric age (259±3 Ma) permits assigning to the Neopaleozoic. The absolute age of the BMV presentes in this work, confirms the spatial relationships observed between the different lithostratigraphic units, and supports the conclusion that the magmatic activity in the area is initiated in the Neopaleozoic, prior to the formation and filling of the Marayes-El Carrizal basin (au)

  14. Prevalência de sintomas depressivos e ansiosos em pacientes com dor crônica

    Directory of Open Access Journals (Sweden)

    Ricardo Cardoso Pinheiro

    2014-09-01

    Full Text Available Objetivos O presente estudo objetivou avaliar a prevalência de sintomas ansiosos e depressivos e relacioná-los com os diferentes tipos e magnitudes de dor crônica; também objetivou caracterizar a população de casos novos agendados para atendimento no ambulatório de dor crônica, no serviço onde o estudo foi realizado. Métodos Estudo de corte transversal, realizado em um ambulatório docente-assistencial para tratamento de dor crônica, realizado entre maio de 2012 e abril de 2013, com 125 pacientes. Instrumentos utilizados Questionário sociodemográfico, Escala Hospitalar de Ansiedade e Depressão (HAD e Escala Visual Numérica (EVN para aferir a intensidade de dor. Resultados Dor intensa foi referida por 64% (n = 80 dos pacientes. Ansiedade atingiu 65% (N = 82 dos pacientes e a depressão, 48% (N = 60. Houve correlação significante entre os mais altos escores de ansiedade (p < 0,001 e depressão (p < 0,001 com a intensidade de dor. A correlação entre intensidade de dor e sintomas ansiosos e depressivos foi positiva para dor crônica neuropática e mista. Os fatores sociodemográficos associados à intensidade de dor crônica foram: renda e religião para depressão, e tempo de dor para ansiedade. Conclusão O estudo mostrou elevada prevalência de sintomas depressivos e ansiosos em pacientes com dor crônica, assim como relação significante desses sintomas psiquiátricos com alguns tipos e intensidade de dor.

  15. Gender Differences in Depression Symptoms: Findings From a Population Survey in Kosovo – A Country in Transition

    OpenAIRE

    Aliriza Arenliu; Kaltrina Kelmendi; Dashamir Berxulli

    2016-01-01

    This paper focuses on gender differences in depression symptoms. It takes into consideration relevant contextual factors of a country in transition. This paper’s analyzed data was extracted from European Social Survey, Sixth Round (ESS-6). ESS uses strict probability samples of the resident national population, aged 15 or older, and living in private households. Females reported a significantly higher mean depression on average (M = 8.14; SD = 3.88) compared to males (M = 7.56; SD = 3.86) at ...

  16. Physics Studies of a Proposed Small Aspect Ratio Torsatron-Tokamak Hybrid

    Science.gov (United States)

    Valanju, P. M.; Gentle, K. W.; McCool, S.; Miner, W. H., Jr.; Ross, D. W.; Wiley, J. C.; Wootton, A. J.

    1996-11-01

    Physics studies of a proposed small aspect ratio torsatron-tokamak hybrid (SMARTH) are presented. This small aspect ratio configuration attempts to remedy a major drawback of conventional stellarator reactors, viz. the large volume resulting from the large aspect ratio. Considering a small aspect ratio machine with 8 field periods (m=8) and with 8 or 16 modular coils, we investigate vacuum configurations and MHD equilibria to determine the optimum configuration which produces large rotational transform, large plasma volume, large beta, and small field ripple. Implications for particle confinement will also be discussed. Effects of radial electric fields on orbit losses and confinement will also be explored.

  17. Probabilistic tsunami hazard assessment based on the long-term evaluation of subduction-zone earthquakes along the Sagami Trough, Japan

    Science.gov (United States)

    Hirata, K.; Fujiwara, H.; Nakamura, H.; Osada, M.; Ohsumi, T.; Morikawa, N.; Kawai, S.; Maeda, T.; Matsuyama, H.; Toyama, N.; Kito, T.; Murata, Y.; Saito, R.; Takayama, J.; Akiyama, S.; Korenaga, M.; Abe, Y.; Hashimoto, N.; Hakamata, T.

    2017-12-01

    For the forthcoming large earthquakes along the Sagami Trough where the Philippine Sea Plate is subducting beneath the northeast Japan arc, the Earthquake Research Committee(ERC) /Headquarters for Earthquake Research Promotion, Japanese government (2014a) assessed that M7 and M8 class earthquakes will occur there and defined the possible extent of the earthquake source areas. They assessed 70% and 0% 5% of the occurrence probability within the next 30 years (from Jan. 1, 2014), respectively, for the M7 and M8 class earthquakes. First, we set possible 10 earthquake source areas(ESAs) and 920 ESAs, respectively, for M8 and M7 class earthquakes. Next, we constructed 125 characterized earthquake fault models (CEFMs) and 938 CEFMs, respectively, for M8 and M7 class earthquakes, based on "tsunami receipt" of ERC (2017) (Kitoh et al., 2016, JpGU). All the CEFMs are allowed to have a large slip area for expression of fault slip heterogeneity. For all the CEFMs, we calculate tsunamis by solving a nonlinear long wave equation, using FDM, including runup calculation, over a nesting grid system with a minimum grid size of 50 meters. Finally, we re-distributed the occurrence probability to all CEFMs (Abe et al., 2014, JpGU) and gathered excess probabilities for variable tsunami heights, calculated from all the CEFMs, at every observation point along Pacific coast to get PTHA. We incorporated aleatory uncertainties inherent in tsunami calculation and earthquake fault slip heterogeneity. We considered two kinds of probabilistic hazard models; one is "Present-time hazard model" under an assumption that the earthquake occurrence basically follows a renewal process based on BPT distribution if the latest faulting time was known. The other is "Long-time averaged hazard model" under an assumption that earthquake occurrence follows a stationary Poisson process. We fixed our viewpoint, for example, on the probability that the tsunami height will exceed 3 meters at coastal points in next

  18. Strength distributions of electromagnetic transitions in light nuclei

    International Nuclear Information System (INIS)

    Kostin, V.Ya.; Koval', A.A.; Kopanets, E.G.; Tsytko, S.P.

    1980-01-01

    Distributions of probabilities of electromagnetic transitions from resonance levels of light nuclei with masses A=Z-40 for eight types of transition (epsilon1, epsilon2, M1, M8, isoscalar and isovector) are obtained. Recommended upper limits (RUL) of transition probabilities are determined for each type of transitions. A comparison with analogous characteristics for transitions between bound states is carried out. It has been causes found that RUL for resonance states substantially differ from RUL for transitions between bound states. Possible causes of such difference are discussed

  19. 13C-labeled 18 : 2n-6 recovered in brush border membrane phospholipids short time after administration

    DEFF Research Database (Denmark)

    Vistisen, Bodil; Høy, Carl-Erik

    2004-01-01

    The purpose of the present study was to examine the short-term effect of dietary specific structured triacylglycerols (MLM, M = 8:0, L = 18:2n-6), LLL and MMM on the fatty acid composition of brush border membrane (BBM) phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Rats were...... fatty acids in the two phospholipid pools. Minor effects on BBM-PC and BBM-PE fatty acid profiles (mole-%) were observed. The present study demonstrated for the first time incorporation of C-13-labeled 18:2n-6 into BBM-PC 2 hours and 6 hours after intragastric administration of L*L*L* or ML...

  20. Edge Detection,

    Science.gov (United States)

    1985-09-01

    PROJECT. T ASK0 Artificial Inteligence Laboratory AREA It WORK UNIT NUMBERS V 545 Technology Square ( Cambridge, HA 02139 I I* CONTOOL1LIN@4OFFICE NAME...ARD-A1t62 62 EDGE DETECTION(U) NASSACNUSETTS INST OF TECH CAMBRIDGE 1/1 ARTIFICIAL INTELLIGENCE LAB E C HILDRETH SEP 85 AI-M-8 N99SI4-8S-C-6595...used to carry out this analysis. cce~iO a N) ’.~" D LI’BL. P p ------------ Sj. t i MASSACHUSETTS INSTITUTE OF TECHNOLOGY i ARTIFICIAL INTELLIGENCE

  1. EVALUATION OF HYBRIDS FROM SIMPLE CROSSES USING MAIZE ELITE LANDRACES WITH FORAGE OUTSTANDING CHARACTERISTICS FOR A MEXICAN ARID LAND

    Directory of Open Access Journals (Sweden)

    José L. García Hernández

    2013-04-01

    Full Text Available The Comarca Lagunera region is the most important area of maize forage in México. In this region; which is shared by the Mexican States of Coahuila and Durango, are used a great amount of hybrids and varieties of maize imported from other countries. Generally, these genotypes are not completely adapted to the soil and/or climatic conditions of the region. These antecedents lead scientists to pursuit for genotypes with the best adaptation to such conditions. The present investigation was carried out with the aim to find the best hybrids from the crosses of ten self-pollinating landraces following a diallel mating design. The landraces were obtained from different institutions: a the International Maize and Wheat Improvement Center (CIMMYT, b the “Antonio Narro” Agrarian Autonomist University (UAAAN, and c the National Institute of Agriculture, Forestry and Livestock Research (INIFAP. The following variables were evaluated from the hybrids: whole plant fresh matter yield (FMY, whole plant dry matter (DMY, fresh fruit yield (FFY fresh stem yield (FSY, and fresh foliar yield (FLY. All variables reported as t ha-1. The Griffing statistical analysis was used to determine the general combining ability (GCA, and the specific combining ability (SCA. The highest values of GCA were obtained for the landraces M7, M8, and M9. The hybrids with highest SCA were: M5xM7, M2xM7, M6x10, M4xM8, M5xM8, M8xM10, M2xM5, M1xM10 and M6xM9. Two of these hybrids (M5xM7 and M2xM7 also showed the highest values for FMY and DMY. In conclusion, there is enough variability on FMY and DMY to believe on the possibility to find the most appropriate hybrid for the targeted region, and also to extend the breeding program to other arid lands in México

  2. ICO Topical Meeting on Atmospheric, Volume and Surface Scattering and Propagation Held in Florence, Italy on 27-30 August 1991

    Science.gov (United States)

    1991-01-01

    The waves are supposed scalar for simplicity. The values of the emerging fields result from distinct sequences of scattering or Feynmann trajectories...fluctuations originates in the possible crossing between any two Feynmann trajectories. For an infinite slab this occurence is rather rare. But for a... Richards : "Iterative Restoration Algoritms" Proc. IEEE 9, 432-450, April 1981. ’I 313 I. ~ l.. . . .. IlI 0.18 0.16- noise f44m8a I 0.14- 0.12- pdf

  3. Adaptive Optoelectronic Eyes: Hybrid Sensor/Processor Architectures

    Science.gov (United States)

    2006-11-13

    Ju 1988). The primate visual cortex is a high-performance image processor designed in part to solve this problem through long-range, multi-scale...arrays, as described in the section on photonic multichip module (PMCM) integration below. VCSELVCSEL Vbias GND VDD PD1 PD2 M1 M2 M3 M4 M5 M6 M7 M8 M301...2000), IEEE Computer Society, pp. 142-149, (2000). 17.  E. Peterhans and R. von der Heydt, “Mechanisms of Contour Perception in Monkey Visual Cortex

  4. Observing pre-earthquake features in the Earth atmosphere-ionosphere environment associated with 2017 Tehuantepec and Puebla earthquakes in Mexico

    Science.gov (United States)

    Ouzounov, D.; Pulinets, S. A.; Guiliani, G.; Hernandez-Pajares, M.; Garcia-Rigo, A.; Petrov, L.; Taylor, P. T.; Hatzopoulos, N.; Kafatos, M.

    2017-12-01

    We are presenting a multi parameter study of lithosphere/atmosphere /ionosphere transient phenomena observed in advance of the M8.2 Tehuantepec and M7.1Puebla earthquakes, the largest and most damaging earthquakes ever recorded in Mexico. We are collecting data from four instruments which recorded hourly and daily: 1.Ground Radon variations (Gamma network in Southern CA) ; 2. Outgoing long-wavelength radiation (OLR obtained from NPOES) on the top of the atmosphere (TOA), 3. Atmospheric chemical potential (ACP) obtained from NASA assimilation models and 4. Electron density variations in the ionosphere via GPS Total Electron Content (GPS/TEC). The September M8.2 earthquake was situated about 3200 kilometers south of two-radon monitoring stations in Orange, Southern California. Real time hourly data show a sharp increase on both sensors (160 kilometers apart) on Sept 2 ( 6 days prior to the M8.2 of 09.08.2017 ) and second anomaly appeared again on Sept 11 ( 7 days prior to the M7.1 of 09.19.2017). Those increases in radon coincide (with some delay) with an increase in the atmospheric chemical potential (on Sept. 03 and10 respectively) measured near the epicentral area from satellite data. And subsequently at the end of August there was an increase of infrared radiation observed which was associated with the acceleration of OLR at the TOA observed from NOAA polar orbit satellites reaching a maximum near the epicenter on Sept 5 and Sept 17. The GPS/Total Electron Content data indicated an increase of electron concentration in ionosphere on Sep 7 and Sep 18, 1-2 days before both earthquakes. Before the earthquake ground and satellite data both show a synergetic anomalous trend, a week before the M8.2 Tehuantepec of 09.08.2017 and continuously up to the Puebla earthquake(M7.1 of 09.19.2017) , although the radon variations were observed far from both epicentral areas. We examined the possible correlation between different pre-earthquake signals in the frame of a

  5. Performance of Adaptive Antennas in FH-GSM Using Conventional Beamforming

    DEFF Research Database (Denmark)

    Mogensen, Preben Elgaard; Leth-Espensen, P; Zetterberg, P.

    2000-01-01

    This paper presents the performance of adaptive antennas in a 1/3 reuse frequency hopping GSM network using conventional beamforming. It mainly focuses on C/I improvement for the purpose of capacity enhancement. The performance evaluation has been conducted by means of network computer simulations...... for low azimuth spread values. For large values of azimuth spread (relative to the antenna beamwidth), the performance gain is reduced significantly. For an azimuth spread of 10 degrees-12 degrees, which has been measured in urban macro-cellular environments, the C/I gain for M = 8 is reduced to approx. 5...

  6. Pattern recognition techniques and neo-deterministic seismic hazard: Time dependent scenarios for North-Eastern Italy

    International Nuclear Information System (INIS)

    Peresan, A.; Vaccari, F.; Panza, G.F.; Zuccolo, E.; Gorshkov, A.

    2009-05-01

    An integrated neo-deterministic approach to seismic hazard assessment has been developed that combines different pattern recognition techniques, designed for the space-time identification of strong earthquakes, with algorithms for the realistic modeling of seismic ground motion. The integrated approach allows for a time dependent definition of the seismic input, through the routine updating of earthquake predictions. The scenarios of expected ground motion, associated with the alarmed areas, are defined by means of full waveform modeling. A set of neo-deterministic scenarios of ground motion is defined at regional and local scale, thus providing a prioritization tool for timely prevention and mitigation actions. Constraints about the space and time of occurrence of the impending strong earthquakes are provided by three formally defined and globally tested algorithms, which have been developed according to a pattern recognition scheme. Two algorithms, namely CN and M8, are routinely used for intermediate-term middle-range earthquake predictions, while a third algorithm allows for the identification of the areas prone to large events. These independent procedures have been combined to better constrain the alarmed area. The pattern recognition of earthquake-prone areas does not belong to the family of earthquake prediction algorithms since it does not provide any information about the time of occurrence of the expected earthquakes. Nevertheless, it can be considered as the term-less zero-approximation, which restrains the alerted areas (e.g. defined by CN or M8) to the more precise location of large events. Italy is the only region of moderate seismic activity where the two different prediction algorithms CN and M8S (i.e. a spatially stabilized variant of M8) are applied simultaneously and a real-time test of predictions, for earthquakes with magnitude larger than 5.4, is ongoing since 2003. The application of the CN to the Adriatic region (s.l.), which is relevant

  7. Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists

    Science.gov (United States)

    Chiang, Cindy; Beljanski, Vladimir; Yin, Kevin; Olagnier, David; Ben Yebdri, Fethia; Steel, Courtney; Goulet, Marie-Line; DeFilippis, Victor R.; Streblow, Daniel N.; Haddad, Elias K.; Trautmann, Lydie; Ross, Ted; Lin, Rongtuan

    2015-01-01

    ABSTRACT The cytosolic RIG-I (retinoic acid-inducible gene I) receptor plays a pivotal role in the initiation of the immune response against RNA virus infection by recognizing short 5′-triphosphate (5′ppp)-containing viral RNA and activating the host antiviral innate response. In the present study, we generated novel 5′ppp RIG-I agonists of varieous lengths, structures, and sequences and evaluated the generation of the antiviral and inflammatory responses in human epithelial A549 cells, human innate immune primary cells, and murine models of influenza and chikungunya viral pathogenesis. A 99-nucleotide, uridine-rich hairpin 5′pppRNA termed M8 stimulated an extensive and robust interferon response compared to other modified 5′pppRNA structures, RIG-I aptamers, or poly(I·C). Interestingly, manipulation of the primary RNA sequence alone was sufficient to modulate antiviral activity and inflammatory response, in a manner dependent exclusively on RIG-I and independent of MDA5 and TLR3. Both prophylactic and therapeutic administration of M8 effectively inhibited influenza virus and dengue virus replication in vitro. Furthermore, multiple strains of influenza virus that were resistant to oseltamivir, an FDA-approved therapeutic treatment for influenza, were highly sensitive to inhibition by M8. Finally, prophylactic M8 treatment in vivo prolonged survival and reduced lung viral titers of mice challenged with influenza virus, as well as reducing chikungunya virus-associated foot swelling and viral load. Altogether, these results demonstrate that 5′pppRNA can be rationally designed to achieve a maximal RIG-I-mediated protective antiviral response against human-pathogenic RNA viruses. IMPORTANCE The development of novel therapeutics to treat human-pathogenic RNA viral infections is an important goal to reduce spread of infection and to improve human health and safety. This study investigated the design of an RNA agonist with enhanced antiviral and inflammatory

  8. Experimental benchmark for piping system dynamic-response analyses

    International Nuclear Information System (INIS)

    1981-01-01

    This paper describes the scope and status of a piping system dynamics test program. A 0.20 m(8 in.) nominal diameter test piping specimen is designed to be representative of main heat transport system piping of LMFBR plants. Particular attention is given to representing piping restraints. Applied loadings consider component-induced vibration as well as seismic excitation. The principal objective of the program is to provide a benchmark for verification of piping design methods by correlation of predicted and measured responses. Pre-test analysis results and correlation methods are discussed

  9. The accuracy of satellite radar altimeter data over the Greenland ice sheet determined from airborne laser data

    DEFF Research Database (Denmark)

    Bamber, J.L.; Ekholm, Simon; Krabill, W.

    1998-01-01

    The 336 days of the geodetic phase of ERS-1 provides dense coverage, by satellite radar altimetry, of the whole of the Greenland ice sheet. These data have been used to produce a digital elevation model of the ice sheet. The errors present in the altimeter data were investigated via a comparison......, to 10.3 m +/- 8.4 m for a slope of 0.7 degrees ( the half power beam-width of the ERS-1 radar altimeter). An explanation for the behaviour of the difference as a function of surface slope is given in terms of the pattern of surface roughness on the ice sheet....

  10. The Use of Geothermal Energy at Military Installations.

    Science.gov (United States)

    1976-10-01

    Geothermal Province Source: Austin and Pringle , 1974 Salton Sea Cerro Prieto geothermal field geotherma l field I.I.D. No. 1a I.I.D. No. 2b M_ SC M_ 8C Sodium...1973 at 4.8 MWe . Otake. Japan 13 1 FS 200 ? 5 3000 7~ Growth: Operation began in 1967 at 12 MWe . 60 — expected by 1980 Cerro Prieto , Mexico 75 2...of power plant operati on is infl uenced by one or more of the chemical constituents. In the V Cerro Prieto and Wairakei fields the

  11. Development of new iraqi wheat varieties induced by gamma rays

    International Nuclear Information System (INIS)

    Ibrahim, I.F.; Al-Janabi, K.K.; Al-Maaroof, E.M.; Al-Aubaidi, M.O.; Mahmoud, A.H.; Al-Janabi, A.A.

    1991-01-01

    The aim of the present investigation is to study agronomic traits of three wheat mutants induced by gamma rays and compared with their origin 'Saber Beg' during M 8 - M 11 generations. These mutants showed a moderate resistance to leaf rust and lodging, while the origin was susceptible. Also, these mutants surpassed their origin in seed weight of 100 spikes, weight of 1000 kernels and protein yield per unit area. Chemical and physical analyses of mutant flours indicated that it could be used for bread making successfully.2 fig.,4 tab

  12. Experimental benchmark for piping system dynamic-response analyses

    Energy Technology Data Exchange (ETDEWEB)

    1981-01-01

    This paper describes the scope and status of a piping system dynamics test program. A 0.20 m(8 in.) nominal diameter test piping specimen is designed to be representative of main heat transport system piping of LMFBR plants. Particular attention is given to representing piping restraints. Applied loadings consider component-induced vibration as well as seismic excitation. The principal objective of the program is to provide a benchmark for verification of piping design methods by correlation of predicted and measured responses. Pre-test analysis results and correlation methods are discussed.

  13. Automatic classification of gammas-gamma coincidence matrices; Clasificacion automatizada de matrices de coincidencias Gamma-Gamma

    Energy Technology Data Exchange (ETDEWEB)

    Los Arcos Merino, J. M.; Gonzalez, J. A.

    1978-07-01

    The information obtained during a coincidence experiment, recorded on magnetic tape by a MULTI-8 minicomputer, is transferred to a new tape in 36 bit words, using the program LEC0M8. The classification in two dimensional matrix form is carried out off-line, on a magnetic disk file, by the program CLAFI. On finishing classification one obtains a copy of the coincidence matrix on the second magnetic tape. Both programs are written to be processed in that order with the UNIVAC 1106 computer of J.E.N. (Author) 4 refs.

  14. Combination chemotherapy versus single-agent therapy as first- and second-line treatment in metastatic breast cancer

    DEFF Research Database (Denmark)

    Joensuu, H; Holli, K; Heikkinen, M

    1998-01-01

    PURPOSE: We report results of a randomized prospective study that compared single agents of low toxicity given both as the first-line and second-line chemotherapy with combination chemotherapy in advanced breast cancer with distant metastases. PATIENTS AND METHODS: Patients in the single-agent arm...... three times per week (CEF) followed by M 8 mg/m2 plus vinblastine (V) 6 mg/m2 every 4 weeks. Exclusion criteria included age greater than 70 years, World Health Organization (WHO) performance status greater than 2, prior chemotherapy for metastatic disease, and presence of liver metastases in patients...

  15. The selected spectral data for amidoalkyl naphthol derivatives

    Indian Academy of Sciences (India)

    N-((2-nitro-phenyl)-(2-hydroxy-napthalen-1-yl)-methyl)-acetamide (Table 4, entry 5) Yellow solid, mp 215-217 ℃; IR(KRr) 3405, 3098, 3036, 1648, 1577, 1544, 1436, 1360, 1288, 1166, 1062, 806cm-1. 1H NMR (300 MHz, DMSO-d6), δ: 2.01 (s, 3H), 7.16-7.58 (m, 8H), 7.79-8.08 (m, 3H), 8.55-8.65 (d, 1H), 9.82 (s, 1H).

  16. US Army Corps of Engineers Reconnaissance Report: North Coast of Honduras Flooding,

    Science.gov (United States)

    1988-03-01

    8217its 5-A poSETR I RI AUN/H.AU PLAT 12 3000 3000 ’e Ib,, 3000____ _ Seak,, 20000 1000 A A 3000 2000 1 _ _ __ _ _ _ __ _ _ _ _ _ _ Pieln solid in -4,, 4...MAME 15025󈧶’" 86027150ŕ 120 A, S, M 7. TEPUSTECA S, M 8. PTE. SABA 15031󈧡" 86014102’’ 70 A, S, M 9. PTE. REFORMA AGRARIA 15042� 86000󈧢...2.4.4 Under-utilization of Rural Labor Under-utilization of rural labor is large. About 60% of the oa available man-days in small and medium farms are

  17. Maturidade perceptomotora e sua relação com idade e variáveis contextuais: um estudo com o Bender (B-SPG)

    OpenAIRE

    Pinto, Lariana Paula; Universidade São Francisco - USF; Noronha, Ana Paula Porto; Universidade São Francisco - USF

    2011-01-01

    O presente estudo teve como objetivos avaliar o aspecto maturacional medido pelo teste, e verificar se há diferenças significativas no desempenho em cada idade. Além disso, também foram verificadas diferenças quanto ao ano escolar, sexo e tipo de escola. Participaram do estudo 298 crianças, sendo 155 do sexo masculino (52%), com idades variando de 6 a 10 anos (M=8,24; DP=1,34). Cursavam do primeiro ao quinto ano do ensino fundamental e eram provenientes de escolas pública (47%) e particular (...

  18. Automatic classification of gammas-gamma coincidence matrices

    International Nuclear Information System (INIS)

    Los Arcos Merino, J. M.; Gonzalez, J. A.

    1978-01-01

    The information obtained during a coincidence experiment, recorded on magnetic tape by a MULTI-8 minicomputer, is transferred to a new tape in 36 bit words, using the program LEC0M8. The classification in two dimensional matrix form is carried out off-line, on a magnetic disk file, by the program CLAFI. On finishing classification one obtains a copy of the coincidence matrix on the second magnetic tape. Both programs are written to be processed in that order with the UNIVAC 1106 computer of J.E.N. (Author) 4 refs

  19. Assessment of extreme quantitative precipitation forecasts and development of regional extreme event thresholds using data from HMT-2006 and COOP observers

    Science.gov (United States)

    Ralph, F.M.; Sukovich, E.; Reynolds, D.; Dettinger, M.; Weagle, S.; Clark, W.; Neiman, P.J.

    2010-01-01

    Extreme precipitation events, and the quantitative precipitation forecasts (QPFs) associated with them, are examined. The study uses data from the Hydrometeorology Testbed (HMT), which conducted its first field study in California during the 2005/06 cool season. National Weather Service River Forecast Center (NWS RFC) gridded QPFs for 24-h periods at 24-h (day 1), 48-h (day 2), and 72-h (day 3) forecast lead times plus 24-h quantitative precipitation estimates (QPEs) fromsites in California (CA) and Oregon-Washington (OR-WA) are used. During the 172-day period studied, some sites received more than 254 cm (100 in.) of precipitation. The winter season produced many extreme precipitation events, including 90 instances when a site received more than 7.6 cm (3.0 in.) of precipitation in 24 h (i.e., an "event") and 17 events that exceeded 12.7 cm (24 h)-1 [5.0 in. (24 h)-1]. For the 90 extreme events f.7.6 cm (24 h)-1 [3.0 in. (24 h)-1]g, almost 90% of all the 270 QPFs (days 1-3) were biased low, increasingly so with greater lead time. Of the 17 observed events exceeding 12.7 cm (24 h)-1 [5.0 in. (24 h)-1], only 1 of those events was predicted to be that extreme. Almost all of the extreme events correlated with the presence of atmospheric river conditions. Total seasonal QPF biases for all events fi.e., $0.025 cm (24 h)-1 [0.01 in. (24 h)-1]g were sensitive to local geography and were generally biased low in the California-Nevada River Forecast Center (CNRFC) region and high in the Northwest River Forecast Center(NWRFC) domain. The low bias in CA QPFs improved with shorter forecast lead time and worsened for extreme events. Differences were also noted between the CNRFC and NWRFC in terms of QPF and the frequency of extreme events. A key finding from this study is that there were more precipitation events .7.6 cm (24 h)-1 [3.0 in. (24 h)21] in CA than in OR-WA. Examination of 422 Cooperative Observer Program (COOP) sites in the NWRFC domain and 400 in the CNRFC domain

  20. Kvalitet og udvikling i socialpædagogisk arbejde med anbragte unge

    DEFF Research Database (Denmark)

    Aagerup, Lars

    2013-01-01

    This dissertation explores conceptions of quality in connection to the social educational work with young people in 24 hour care in Denmark, where about 12.000 children and young people are in 24 hour care. The aim of the investigations is to explore the possibilities of a qualitative and context......This dissertation explores conceptions of quality in connection to the social educational work with young people in 24 hour care in Denmark, where about 12.000 children and young people are in 24 hour care. The aim of the investigations is to explore the possibilities of a qualitative...... Christensen, Böcker Jakobsen, Jensen, Fuglsang Olsen, 2009, Fuglsang Olsen, Egelund og Lausten 2011). The research question is: How can quality in the social educational work with young people in 24 hour care be conceived from various positions, and how can these conceptions of quality become part...... theory in the field and relevant research results are used to put the findings in the caseinstitution in general perspectives. The findings of the investigations show several points of interest in the social educational work in the case institution, where the there are several differences between...

  1. A SUBSTELLAR COMMON PROPER-MOTION COMPANION TO THE PLEIAD H II 1348

    International Nuclear Information System (INIS)

    Geißler, Kerstin; Metchev, Stanimir A.; Pham, Alfonse; Larkin, James E.; McElwain, Michael; Hillenbrand, Lynne A.

    2012-01-01

    We announce the identification of a proper-motion companion to the star H II 1348, a K5 V member of the Pleiades open cluster. The existence of a faint point source 1.''1 away from H II 1348 was previously known from adaptive optics imaging by Bouvier et al. However, because of a high likelihood of background star contamination and in the absence of follow-up astrometry, Bouvier et al. tentatively concluded that the candidate companion was not physically associated with H II 1348. We establish the proper-motion association of the pair from adaptive optics imaging with the Palomar 5 m telescope. Adaptive optics spectroscopy with the integral field spectrograph OSIRIS on the Keck 10 m telescope reveals that the companion has a spectral type of M8 ± 1. According to substellar evolution models, the M8 spectral type resides within the substellar mass regime at the age of the Pleiades. The primary itself is a known double-lined spectroscopic binary, which makes the resolved companion, H II 1348B, the least massive and widest component of this hierarchical triple system and the first substellar companion to a stellar primary in the Pleiades.

  2. Electrophilicities and Protein Covalent Binding of Demethylation Metabolites of Colchicine.

    Science.gov (United States)

    Guo, Xiucai; Lin, Dongju; Li, Weiwei; Wang, Kai; Peng, Ying; Zheng, Jiang

    2016-03-21

    Colchicine, an alkaloid existing in plants of Liliaceous colchicum, has been widely used in the treatment of gout and familial Mediterranean fever. The administration of colchicine was found to cause liver injury in humans. The mechanisms of colchicine-induced liver toxicity remain unknown. The objectives of this study were to determine the electrophilicities of demethylation metabolites of colchicine and investigate the protein adductions derived from the reactive metabolites of colchicine. Four demethylated colchicine (1-, 2-, 3-, and 10-DMCs), namely, M1-M4, were detected in colchicine-fortified microsomal incubations. Four N-acetyl cysteine (NAC) conjugates (M5-M8) derived from colchicine were detected in the microsomes in the presence of NAC. M5 and M6 were derived from 10-DMC. M7 resulted from the reaction of 2-DMC or 3-DMC with NAC, and M8 originated from 10-DMC. Microsomal protein covalent binding was observed after exposure to colchicine. Two cysteine adducts (CA-1 and CA-2) derived from 10-DMC were found in proteolytically digested microsomal protein samples after incubation with colchicine. The findings allow us to define the chemical property of demethylation metabolites of colchicine and the interaction between protein and the reactive metabolites of colchicine generated in situ.

  3. Karyotype characterization and ZZ/ZW sex chromosome heteromorphism in two species of the catfish genus Ancistrus Kner, 1854 (Siluriformes: Loricariidae from the Amazon basin

    Directory of Open Access Journals (Sweden)

    Renildo R. de Oliveira

    Full Text Available We present karyotypic characteristics and report on the occurrence of ZZ/ZW sex chromosomes in Ancistrus ranunculus (rio Xingu and Ancistrus sp. "Piagaçu" (rio Purus, of the Brazilian Amazon. Ancistrus ranunculus has a modal number of 2n=48 chromosomes, a fundamental number (FN of 82 for both sexes, and the karyotypic formula was 20m+8sm+6st+14a for males and 19m+9sm+6st+14a for females. Ancistrus sp. "Piagaçu" presented 2n=52 chromosomes, FN= 78 for males and FN= 79 for females. The karyotypic formula was 16m+8sm+2st+26a for males and 16m+9sm+2st+25a for females. The high number of acrocentric chromosomes in karyotype of Ancistrus sp. "Piagaçu" differs from the majority of Ancistrini genera studied so far, and may have resulted from pericentric inversions and translocations. The lower number of chromosomes in A. ranunculus indicates that centric fusions also occurred in the evolution of Ancistrus karyotypes. We conclude that karyotypic characteristics and the presence of sex chromosomes can constitute important cytotaxonomic markers to identify cryptic species of Ancistrus. However, sex chromosomes apparently arose independently within the genus and thus do not constitute a reliable character to analyze phylogenetic relations among Ancistrus species.

  4. Identification of rotundic acid metabolites after oral administration to rats and comparison with the biotransformation by Syncephalastrum racemosum AS 3.264.

    Science.gov (United States)

    Li, Hui; Yang, Bao; Cao, Di; Zhou, Lian; Wang, Qing; Rong, Li; Zhou, Xinghong; Jin, Jing; Zhao, Zhongxiang

    2018-02-20

    The objective of this study was to identify the metabolites of rotundic acid after oral administration to rats and compare the similarities with its biotransformation by Syncephalastrum racemosum AS 3.264 using ultra-high performance liquid chromatography coupled with quadrupole time of flight mass spectrometry. A total of fourteen metabolites were determined based on the mass spectrometry and chromatographic behaviors, among which eleven (M1-M3, M7-M14) and six (M2, M4-M8) metabolites were identified in rats and S. racemosum, respectively. Three identical metabolites (M2, M7 and M8) were found in rats and S. racemosum, indicating that there were metabolic similarities. Moreover, to confirm the results of mass spectrometry, three (M2, M4 and M7) metabolites were obtained by the means of amplifying incubation and their structures were determined by various spectroscopic analyses, and M4 was proved to be a previously undescribed compound. This results showed that in vitro assisted preparation by microbial transformation is a feasible and effective method of obtaining metabolites which are in low amounts and difficult to be prepared in vivo. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus

    Directory of Open Access Journals (Sweden)

    Katie A. Howell

    2017-04-01

    Full Text Available Drug combinations are synergistic when their combined efficacy exceeds the sum of the individual actions, but they rarely include ineffective drugs that become effective only in combination. We identified several “enabling pairs” of neutralizing and non-neutralizing anti-ebolavirus monoclonal antibodies, whose combination exhibited new functional profiles, including transforming a non-neutralizing antibody to a neutralizer. Sub-neutralizing concentrations of antibodies 2G4 or m8C4 enabled non-neutralizing antibody FVM09 (IC50 >1 μM to exhibit potent neutralization (IC50 1–10 nM. While FVM09 or m8C4 alone failed to protect Ebola-virus-infected mice, a combination of the two antibodies provided 100% protection. Furthermore, non-neutralizers FVM09 and FVM02 exponentially enhanced the potency of two neutralizing antibodies against both Ebola and Sudan viruses. We identified a hotspot for the binding of these enabling antibody pairs near the interface of the glycan cap and GP2. Enabling cooperativity may be an underappreciated phenomenon for viruses, with implications for the design and development of immunotherapeutics and vaccines.

  6. Effects of strong earthquakes in variations of electrical and meteorological parameters of the near-surface atmosphere in Kamchatka region

    Science.gov (United States)

    Smirnov, S. E.; Mikhailova, G. A.; Mikhailov, Yu. M.; Kapustina, O. V.

    2017-09-01

    The diurnal variations in electrical (quasistatic electric field and electrical conductivity) and meteorological (temperature, pressure, relative humidity of the atmosphere, and wind speed) parameters, measured simultaneously before strong earthquakes in Kamchatka region (November 15, 2006, M = 8.3; January 13, 2007, M = 8.1; January 30, 2016, M = 7.2), are studied for the first time in detail. It is found that a successively anomalous increase in temperature, despite the negative regular trend in these winter months, was observed in the period of six-seven days before the occurrences of earthquakes. An anomalous temperature increase led to the formation of "winter thunderstorm" conditions in the near-surface atmosphere of Kamchatka region, which was manifested in the appearance of an anomalous, type 2 electrical signal, the amplification of and intensive variations in electrical conductivity, heavy precipitation (snow showers), high relative humidity of air, storm winds, and pressure changes. With the weak flow of natural heat radiation in this season, the observed dynamics of electric and meteorological processes can likely be explained by the appearance of an additional heat source of seismic nature.

  7. Synthesis and Bioactivity Evaluation of Novel 2-Salicyloylbenzofurans as Antibacterial Agents

    Directory of Open Access Journals (Sweden)

    Phuong-Thuy T. Phan

    2017-04-01

    Full Text Available In order to discover new antibacterial agents, series of 2-salicyloylbenzofuran derivatives were designed, synthesized and evaluated for their antibacterial activities against three Gram-(+ strains (methicillin-sensitive Staphylococcus aureus (MSSA ATCC 29213, methicillin-resistant Staphylococcus aureus (MRSA ATCC 43300, and Streptococcus faecalis (S. faecalis ATCC 29212 and one Gram-(− strain (Escherichia coli (E. coli ATCC 25922. The 2-salicyloylbenzofuran heterocycles were generated by Rap–Stoermer condensation of salicylaldehydes with phenacyl bromides and then converted to diverse O-ether derivatives by Williamson synthesis. The targeted products were screened for in vitro qualitative (zone of inhibition and quantitative (MIC antibacterial activities by agar well diffusion assay and agar dilution method. Amongst the compounds, those bearing carboxylic acid functional group were found to exhibit reasonable activity against Gram-(+ bacterial strains including S. faecalis, MSSA and MRSA with the most potent antibacterial agent 8h (MICs = 0.06–0.12 mM. Besides, the 2-salicyloylbenzofurans partly displayed inhibitory activity against MRSA with the best MICs = 0.14 mM (8f and 0.12 mM (8h. Finally, the antibacterial results preliminarily suggested that the substituent bearing carboxylic acid group at salicyloyl-C2 and the bromine atoms on the benzofuran moiety seem to be the functionality necessary for antibacterial activities.

  8. Iron availability in the presence of β-carotene in different mixtures

    Directory of Open Access Journals (Sweden)

    Romilda Maria de Arruda Germano

    2011-06-01

    Full Text Available Iron availability in the diet is very important because iron deficiency affects a large population in the world. The matrix where iron is present has an influence in its availability. The presence of β-carotene is a factor that alters the availability of iron. This research aims to estimate the iron availability in the presence of β-carotene in food mixtures: M1 = egg and pumpkin; M2 = spinach and pumpkin; M3 = spinach and cabbage; M4 = egg and cabbage; M5 = spinach and carrot; M6 = egg and carrot; M7 = bean and carrot; M8 = bean and pumpkin and M9 = bean and cabbage. After cooking, the following figures were determined: proximate composition, oxalic acid, phytic acid, tannin, iron, iron availability in vitro and β-carotene. The data were analyzed by Tukey test (5%. There were no significant statistical differences for oxalic acid. Tannin presented greater results in mixtures with spinach (M2 and M5; phytic acid was greater in bean samples (M7, M8 and M9 and with spinach (M2. Mixtures M5 e M7, with carrot, presented more β-carotene than the others. The best result for iron availability appeared in mixture (M6. A positive correlation was verified between protein and iron dialysis, and between lipids and iron dialysis. Dietetic fiber was an inhibitor to iron availability. Mixtures with egg showed greater iron availability

  9. Na+,K+-ATPase amino acids involved in transport of the 3rd sodium ion

    DEFF Research Database (Denmark)

    Holm, Rikke; Einholm, Anja P.; Toustrup-Jensen, Mads Schak

    . I have mutated several residues of the rat α1 isoform related to the channel structure and have characterized the effects on Na+ and K+ affinities and the E2-E1 and E1P-E2P conformational transitions of the pump cycle. Mutation D928N of rat α1, equivalent to D923N of human α3, shows a conspicuous......Available evidence indicates that two of the three Na+ ions bound in the E1 form occupy approximately the same positions as the K+ ions in E2, but the location of the third Na+ ion is unsolved. We have previously found a marked decrease in Na+ affinity for activation of phosphorylation in the human...... α3 mutant D923N, which is associated with RDP [1]. D923 is located in the cytoplasmic half of transmembrane helix M8 in a putative transport channel between M5, M7, M8 and M10. The external K+ sites behaved wild type (wt)-like in the mutant, suggesting that D923 is associated with the third Na+ ion...

  10. Prompt electromagnetic transients from binary black hole mergers

    Science.gov (United States)

    Kelly, Bernard J.; Baker, John G.; Etienne, Zachariah B.; Giacomazzo, Bruno; Schnittman, Jeremy

    2017-12-01

    Binary black hole (BBH) mergers provide a prime source for current and future interferometric gravitational wave observatories. Massive BBH mergers may often take place in plasma-rich environments, leading to the exciting possibility of a concurrent electromagnetic (EM) signal observable by traditional astronomical facilities. However, many critical questions about the generation of such counterparts remain unanswered. We explore mechanisms that may drive EM counterparts with magnetohydrodynamic simulations treating a range of scenarios involving equal-mass black-hole binaries immersed in an initially homogeneous fluid with uniform, orbitally aligned magnetic fields. We find that the time development of Poynting luminosity, which may drive jetlike emissions, is relatively insensitive to aspects of the initial configuration. In particular, over a significant range of initial values, the central magnetic field strength is effectively regulated by the gas flow to yield a Poynting luminosity of 1 045-1046ρ-13M8 2 erg s-1 , with BBH mass scaled to M8≡M /(108 M⊙) and ambient density ρ-13≡ρ /(10-13 g cm-3) . We also calculate the direct plasma synchrotron emissions processed through geodesic ray-tracing. Despite lensing effects and dynamics, we find the observed synchrotron flux varies little leading up to merger.

  11. A State-Space Approach to Explore the Strain Behavior before and after the 2003 Tokachi-Oki Earthquake (M81

    Directory of Open Access Journals (Sweden)

    T Takanami

    2013-04-01

    Full Text Available The Earth's surface is under the continuous influence of a variety of natural forces and human induced sources. Strain data are good examples of such disturbed signals. To determine the geodetic strain behavior before and after the 2003 Tokachi-oki earthquake (M8.0, we decomposed the disturbed strain data into trend, air pressure, earth tide, and precipitation responses components. The decomposition of the disturbed strain data and the interpolation of the missing observations are performed very effectively by using state-space modeling and the Kalman filter/smoother. The validity of the data processing is confirmed by the fact that the model derived to fit the strain data matches the GPS data extremely well. 1The following contribution was presented at the WDS conference and presents a more complete explanation of the data processing and its implementation. Subsequent to the Conference, the authors completed their research and have published a comprehensive paper presenting their final results in [Modeling of the post-seismic slip of the 2003 Tokachi-oki earthquake 'M'8 off Hokkaido: constraints from volumetric strain, 'Earth, Planets and Space', doi: 10.5047/eps.2012.12.003, in press]. That paper includes not only a preliminary data processing presented here, but also contains many additional results concerned with a geophysical phenomenon. The CODATA Data Science Journal regrets the delay in publishing this conference paper.

  12. Seismicity of the Earth 1900-2010 eastern margin of the Australia plate

    Science.gov (United States)

    Benz, Harley M.; Herman, Matthew; Tarr, Arthur C.; Hayes, Gavin P.; Furlong, Kevin P.; Villaseñor, Antonio; Dart, Richard L.; Rhea, Susan

    2011-01-01

    The eastern margin of the Australia plate is one of the most seismically active areas of the world due to high rates of convergence between the Australia and Pacific plates. In the region of New Zealand, the 3,000 km long Australia-Pacific plate boundary extends from south of Macquarie Island to the southern Kermadec Island chain. It includes an oceanic transform (the Macquarie Ridge), two oppositely verging subduction zones (Puysegur and Hikurangi), and a transpressive continental transform, the Alpine Fault through South Island, New Zealand. Since 1900, there have been 15 M7.5+ earthquakes recorded near New Zealand. Nine of these, and the four largest, occurred along or near the Macquarie Ridge, including the 1989 M8.2 event on the ridge itself, and the 2004 M8.1 event 200 km to the west of the plate boundary, reflecting intraplate deformation. The largest recorded earthquake in New Zealand itself was the 1931 M7.8 Hawke's Bay earthquake, which killed 256 people. The last M7.5+ earthquake along the Alpine Fault was 170 years ago; studies of the faults' strain accumulation suggest that similar events are likely to occur again.

  13. Effects of pregnancy on hemoglobin AIc in normal, gestational diabetic, and diabetic women.

    Science.gov (United States)

    Schwartz, H C; King, K C; Schwartz, A L; Edmunds, D; Schwartz, R

    1976-12-01

    Hemoglobin AIc, a normal minor hemoglobin, has glucose linked by a Schiff base to the N-terminal end of the beta chain. The glucose interferes with the binding of 2,3 diphosphoglycerate, probably resulting in an increased affinity of that hemoglobin for oxygen. Hb AIc is increased to twice normal levels in juvenile-onset (insulin-dependent) diabetes. In the present studies, the Hb AIc, when expressed as per cent of total hemoglobin, was found to be elevated slightly in pregnany normal (m = 6.97 per cent), pregnant nondiabetic obese (m = 6.89 per cent), and gestationally diabetic subjects (m = 8.77 per cent) above that of normal females (m = 5.68 per cent). A remarkable difference was observed between the nonpregnant diabetics (m = 12.77 per cent) and the pregnant diabetics (m = 8.46 per cent). This decrease in the level of Hb AIc in diabetics who are pregnant more than 30 weeks may reflect either a better state of diabetic control and/or a compensatory mechanism to protect the fetus by facilitating oxygen exchange from mother to fetus.

  14. Bayesian exploration of recent Chilean earthquakes

    Science.gov (United States)

    Duputel, Zacharie; Jiang, Junle; Jolivet, Romain; Simons, Mark; Rivera, Luis; Ampuero, Jean-Paul; Liang, Cunren; Agram, Piyush; Owen, Susan; Ortega, Francisco; Minson, Sarah

    2016-04-01

    The South-American subduction zone is an exceptional natural laboratory for investigating the behavior of large faults over the earthquake cycle. It is also a playground to develop novel modeling techniques combining different datasets. Coastal Chile was impacted by two major earthquakes in the last two years: the 2015 M 8.3 Illapel earthquake in central Chile and the 2014 M 8.1 Iquique earthquake that ruptured the central portion of the 1877 seismic gap in northern Chile. To gain better understanding of the distribution of co-seismic slip for those two earthquakes, we derive joint kinematic finite fault models using a combination of static GPS offsets, radar interferograms, tsunami measurements, high-rate GPS waveforms and strong motion data. Our modeling approach follows a Bayesian formulation devoid of a priori smoothing thereby allowing us to maximize spatial resolution of the inferred family of models. The adopted approach also attempts to account for major sources of uncertainty in the Green's functions. The results reveal different rupture behaviors for the 2014 Iquique and 2015 Illapel earthquakes. The 2014 Iquique earthquake involved a sharp slip zone and did not rupture to the trench. The 2015 Illapel earthquake nucleated close to the coast and propagated toward the trench with significant slip apparently reaching the trench or at least very close to the trench. At the inherent resolution of our models, we also present the relationship of co-seismic models to the spatial distribution of foreshocks, aftershocks and fault coupling models.

  15. Extended-spectrum β-lactamases, transferable quinolone resistance, and virulotyping in extra-intestinal E. coli in Uruguay.

    Science.gov (United States)

    Vignoli, Rafael; García-Fulgueiras, Virginia; Cordeiro, Nicolás F; Bado, Inés; Seija, Verónica; Aguerrebere, Paula; Laguna, Gabriel; Araújo, Lucía; Bazet, Cristina; Gutkind, Gabriel; Chabalgoity, José

    2016-01-31

    To characterize extended-spectrum β-lactamases (ESBLs) and plasmid-mediated quinolone resistance (PMQR) genes in Escherichia coli isolates obtained from extra-intestinal samples in three Uruguayan hospitals. Fifty-five ESBL-producing E. coli isolates were studied. Virulence genes, ESBLs, and PMQR genes were detected by polymerase chain reaction. ESBL-producing isolates were compared by pulsed-field gel electrophoresis. Multi-locus sequence typing was also performed on 13 selected isolates. Thirty-seven isolates harbored blaCTX-M-15 (67.3%), eight blaCTX-M-2 (14.6%), five blaCTX-M-14 (9.1%), three carried both blaCTX-M-2 and blaCTX-M-14, one blaCTX-M-9, and one blaCTX-M-8. Among the CTX-M-15 producers, 92% belonged to sequence types ST131 and ST405, and carried aac(6')Ib-cr as well. Isolates harboring blaCTX-M-2, blaCTX-M-14, blaCTX-M-9, or blaCTX-M-8 were found to be genetically unrelated. The successful dissemination of CTX-M-15-producing E.coli isolates seems to be linked to the spreading of high-risk clones and horizontal gene transfer. A trade-off between carrying more antibiotic resistance and less virulence-related genes could partially account for the evolutionary advantages featured by successful clones.

  16. Seismicity, topography, and free-air gravity of the Aleutian-Alaska subduction zone

    Science.gov (United States)

    Wells, R. E.; Blakely, R. J.; Scholl, D. W.; Ryan, H. F.

    2011-12-01

    The Aleutian-Alaska subduction zone, extending 3400 km from the Queen Charlotte Fault to Kamchatka, has been the source of six great megathrust earthquakes in the 20th Century. Four earthquakes have ruptured the 2000-km-long Aleutian segment, where the Cenozoic Aleutian arc overlies the subducting Pacific plate. These include the 1946 M 8.6 earthquake off Unimak Is., the 1957 M 8.6 and 1986 M 8.0 earthquakes off the Andreanoff Is., and the 1965 M 8.7 Rat Is. earthquake. The source regions of these earthquakes inferred from waveform inversions underlie the well-defined Aleutian deep-sea terrace. The deep-sea terrace is about 4 km deep and is underlain by Eocene arc framework rocks, which extend nearly to the trench. It is bounded on its seaward and landward margins by strong topographic and fee-air gravity gradients. The main asperities (areas of largest slip) for the great earthquakes and nearly all of the Aleutian thrust CMT solutions lie beneath the Aleutian terrace, between the maximum gradients. Similar deep-sea terraces are characteristic of non-accretionary convergent margins globally (75% of subduction zones), and, where sampled by drilling (e.g., Japan, Peru, Tonga, Central America), are undergoing sustained subsidence. Sustained subsidence requires removal of arc crust beneath the terrace by basal subduction erosion (BSE). BSE is in part linked to the seismic cycle, as it occurs in the same location as the megathrust earthquakes. Along the eastern 1400 km of the Alaskan subduction zone, the Pacific plate subducts beneath the North American continent. The boundary between the Aleutian segment and the continent is well defined in free-air gravity, and the distinctive deep-sea terrace observed along the Aleutian segment is absent. Instead, the Alaskan margin consists of exhumed, underplated accretionary complexes forming outer arc gravity highs. Superimposed on them are broad topographic highs and lows forming forearc basins (Shumagin, Stevenson) and islands

  17. Aquatic ecotoxicity effect of engineered aminoclay nanoparticles

    DEFF Research Database (Denmark)

    Choi, Moon-Hee; Hwang, Yuhoon; Uk Lee, Hyun

    2014-01-01

    In the present study the short term aquatic ecotoxicity of water-solubilized aminoclay nanoparticles (ANPs) of ~51±31 nm average hydrodynamic diameter was characterized. An ecotoxicological evaluation was carried out utilizing standard test organisms of different phyla and trophic levels namely...... with 100 mg/L in 24 h while in 48 h a single animal was immobilized (5% inhibition). Correspondingly, the NOEC of ANP in 24 h was 100 mg/L and the lowest observed effect concentration (LOEC) for 48 h was 100 mg/L. Therefore it can be considered to use ANP as an algal-inhibition agent at concentrations

  18. HLA-DP antigens in patients with alopecia areata

    DEFF Research Database (Denmark)

    Ødum, Niels; Morling, N; Georgsen, J

    1990-01-01

    The distribution of HLA-DP antigens were studied in 41 patients with alopecia areata (AA) and 188 ethnically matched controls. An increase of DR4 and possibly DR5 in 24 of these patients has previously been reported. HLA-DP typing for DPw1 through w6 and the local specificity, CDP HEI, was perfor......The distribution of HLA-DP antigens were studied in 41 patients with alopecia areata (AA) and 188 ethnically matched controls. An increase of DR4 and possibly DR5 in 24 of these patients has previously been reported. HLA-DP typing for DPw1 through w6 and the local specificity, CDP HEI...

  19. 24 CFR 92.258 - Elder cottage housing opportunity (ECHO) units.

    Science.gov (United States)

    2010-04-01

    ... designed to be installed adjacent to existing single-family dwellings. (b) Eligible owners. The owner of a HOME-assisted ECHO unit may be: (1) The owner-occupant of the single-family host property on which the... elderly or disabled family as defined in 24 CFR 5.403 and must also be a low-income family. (d) Applicable...

  20. Objective determination of pH thresholds in the analysis of 24 h ambulatory oesophageal pH monitoring

    NARCIS (Netherlands)

    Weusten, B. L.; Roelofs, J. M.; Akkermans, L. M.; vanBerge-Henegouwen, G. P.; Smout, A. J.

    1996-01-01

    In 24 h oesophageal pH monitoring, pH 4 is widely but arbitrarily used as the threshold between reflux and non-reflux pH values. The aim of the study was to define pH thresholds objectively, based on Gaussian curve fitting of pH frequency distributions. Single-channel 24 h oesophageal pH monitoring

  1. Genome-wide association study of prostate cancer-specific survival

    DEFF Research Database (Denmark)

    Szulkin, Robert; Karlsson, Robert; Whitington, Thomas

    2015-01-01

    BACKGROUND: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. METHODS: We performed a genome-wide survival analysis of cause-specific death in 24,...

  2. Venous muscle pump function during pregnancy. Assessment by ambulatory strain-gauge plethysmography

    DEFF Research Database (Denmark)

    Struckmann, J R; Meiland, H; Bagi, P

    1990-01-01

    The venous muscle pump function was quantitatively assessed through pregnancy weeks 16, 30, 38 and 3 months (week 53) following delivery, in 24 pregnant women who completed a normal pregnancy. A statistically significant increase was found in the mean venous reflux (P less than 0.01), which was r...

  3. Blood pressure measurement of all five fingers by strain gauge plethysmography

    DEFF Research Database (Denmark)

    Hirai, M; Nielsen, S L; Lassen, N A

    1976-01-01

    The aim of the present paper was to study the methodological problems involved in measuring systolic blood pressure in all five fingers by the strain gauge technique. In 24 normal subjects, blood pressure at the proximal phalanx of finger I and both at the proximal and the intermediate phalanx of...

  4. The Effects of a Memory Aid on Three Types of Conversation Judgments

    Science.gov (United States)

    Rybash, John M.; And Others

    1975-01-01

    A study of the effects of three types of conservation judgments (qualitative, quantitative, and equivalence) on both continuous and discontinuous substances in 24, 4-, 5-, and 6-year-olds. Subjects were tested on conservation ability with and without verbal justification. Half of the subjects were provided a memory aid, the other half were not.…

  5. Experiment list: SRX810435 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available idity in Shneider S2 Drosophila medium(Gibco) supplement...ster; ChIP-Seq source_name=Cell culture || cell line=S2 || chip antibody=none || growth protocol=S2 cells were grown in 24°C, 95% hum

  6. Experiment list: SRX810433 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available er; ChIP-Seq source_name=Cell culture || cell line=S2 || chip antibody=none || growth protocol=S2 cells were grown in 24°C, 95% humid...ity in Shneider S2 Drosophila medium(Gibco) supplemented

  7. Experiment list: SRX810434 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available idity in Shneider S2 Drosophila medium(Gibco) supplement...ster; ChIP-Seq source_name=Cell culture || cell line=S2 || chip antibody=none || growth protocol=S2 cells were grown in 24°C, 95% hum

  8. Adolescent reports of experiencing gender based violence: findings ...

    African Journals Online (AJOL)

    The aim of this paper is to describe adolescent reports of gender based violence (GBV) based on a cross-sectional survey conducted with grade 8 boys and girls in high schools. . Self-completed paper based surveys were implemented with 1756 adolescents in 24 Johannesburg high schools in 2012 and with 2202 ...

  9. Effect of low-dose aspirin during pregnancy on fibrinolytic variables before and after parturition

    NARCIS (Netherlands)

    H.A. Bremer (Henk); N. Rotmans (Nel); E.J.Ph. Brommer; H.C.S. Wallenburg (Henk)

    1995-01-01

    textabstractOBJECTIVE: We assessed the effects of a daily oral dose of 60 to 80 mg of aspirin from 12 weeks gestation until delivery on fibrinolytic variables before and after parturition. STUDY DESIGN: In a prospective controlled study labor was electively induced in 24 patients, eight receiving

  10. Lower Extremity Paralysis.

    Science.gov (United States)

    Glancy, D Luke; Subramaniam, Pramilla N; Rodriguez, Juan F

    2016-11-15

    Severe hypokalemia in the absence of other electrolyte abnormalities, the result of diarrhea, caused striking electrocardiographic changes, generalized weakness, flaccid paralysis of the lower extremities, and biochemical evidence of mild skeletal and cardiac rhabdomyolysis in a 33-year-old man. Repletion of potassium reversed all abnormalities in 24 hours. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Holt Oram syndrome: a registry-based study in Europe

    DEFF Research Database (Denmark)

    Barisic, Ingeborg; Boban, Ljubica; Greenlees, Ruth

    2014-01-01

    were reported in all cases. Agenesis/hypoplasia of radius was present in 49.2% (30/61), ulnar aplasia/hypoplasia in 24.6% (15/61) and humerus hypoplasia/phocomelia in 42.6% (26/61) of patients. Congenital heart defects (CHD) were recorded in 78.7% (48/61) of patients. Isolated septal defects were...

  12. The Role of Physical Education Lessons and Recesses in School Lifestyle of Adolescents

    Science.gov (United States)

    Frömel, Karel; Svozil, Zbynek; Chmelík, František; Jakubec, Lukáš; Groffik, Dorota

    2016-01-01

    Background: This study investigates school lifestyle among adolescents in terms of physical activity (PA) structure: (1) adolescents participating in a physical education lesson (PEL) versus (2) aggregate recess time exceeding 60 minutes. Methods: The research was conducted in 24 secondary schools in the Czech Republic (boys N = 208, girls N =…

  13. 24 CFR 886.131 - Audit.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Audit. 886.131 Section 886.131... Projects With HUD-Insured and HUD-Held Mortgages § 886.131 Audit. (a) Where a State or local government is... assistance under this part, the audit requirements in 24 CFR part 44 shall apply. (b) Where a nonprofit...

  14. 24 CFR 214.500 - Audit.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Audit. 214.500 Section 214.500... PROGRAM Other Federal Requirements § 214.500 Audit. Housing counseling grant recipients and subrecipients shall be subject to the audit requirements contained in 24 CFR parts 84 and 85. HUD must be provided a...

  15. 24 CFR 941.209 - Audit.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Audit. 941.209 Section 941.209... HOUSING DEVELOPMENT PHA Eligibility and Program Requirements § 941.209 Audit. All PHAs that receive funds under this part for the development of low-income housing shall comply with audit requirements in 24 CFR...

  16. 24 CFR 886.336 - Audit.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Audit. 886.336 Section 886.336... the Disposition of HUD-Owned Projects § 886.336 Audit. (a) Where a State or local government is the eligible owner of a project receiving financial assistance under this part, the audit requirements in 24...

  17. 24 CFR 882.124 - Audit.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Audit. 882.124 Section 882.124...) SECTION 8 MODERATE REHABILITATION PROGRAMS Applicability, Scope and Basic Policies § 882.124 Audit. PHAs receiving financial assistance under this part are subject to audit requirements in 24 CFR part 44. [50 FR...

  18. 24 CFR 884.124 - Audit.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Audit. 884.124 Section 884.124... HOUSING PROJECTS Applicability, Scope and Basic Policies § 884.124 Audit. (a) Where a State or local..., receiving financial assistance under this part, the audit requirements in 24 CFR part 44 shall apply. (b...

  19. 24 CFR 880.211 - Audit.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Audit. 880.211 Section 880.211... § 880.211 Audit. (a) Where a State or local government is the eligible owner of a project or a contract administrator under § 880.505 receiving financial assistance under this part, the audit requirements in 24 CFR...

  20. 24 CFR 883.313 - Audit.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Audit. 883.313 Section 883.313... § 883.313 Audit. (a) Where housing assistance under the Section 8 Program is provided for projects developed by State agencies, these agencies shall follow audit requirements in 24 CFR part 44. (b) Where a...

  1. Morphosyntax and Logical Abilities in Italian Poor Readers: The Problem of SLI Under-Identification

    Science.gov (United States)

    Arosio, Fabrizio; Pagliarini, Elena; Perugini, Maria; Barbieri, Lina; Guasti, Maria Teresa

    2016-01-01

    The study investigated morphosyntactic abilities and semantic-pragmatic competence in 24 children with developmental dyslexia aged 7-12 years. Morphosyntactic abilities were investgated in a direct object clitic production task, semantic-pragmatic competence in a quantifier comprehension task. Children with dyslexia produced fewer clitics than…

  2. Evaluation of the results of operative treatment of hip dysplasia in ...

    African Journals Online (AJOL)

    El-Sayed Abdel Halim Abdullah

    2012-02-25

    Feb 25, 2012 ... of open reduction, femoral (shortening, derotation and varus) and pelvic (Salter or Dega) osteot- omy. The age at the time of the operation ranged from 18 to 96 months. Results: At the end of follow-up (a mean of 33.5 months), the overall final clinical result was excel- lent in 13 (31%) patients, good in 24 ...

  3. Memory retention in wild-type and tau mutant Syrian hamsters

    NARCIS (Netherlands)

    Oklejewicz, M; Van Der Zee, EA; Gerkema, MP; Daan, S

    Rats are known to display a temporary deficit in memory function 6 h after training on a learning task, a phenomenon known as the 'Kamin effect'. Later studies showed that maximal retrieval recurs in 24 h intervals after a single training and implied the role of the circadian clock in the

  4. Print News Coverage of School-Based Human Papillomavirus Vaccine Mandates

    Science.gov (United States)

    Casciotti, Dana M.; Smith, Katherine C.; Andon, Lindsay; Vernick, Jon; Tsui, Amy; Klassen, Ann C.

    2014-01-01

    Background: In 2007, legislation was proposed in 24 states and the District of Columbia for school-based human papillomavirus (HPV) vaccine mandates, and mandates were enacted in Texas, Virginia, and the District of Columbia. Media coverage of these events was extensive, and media messages both reflected and contributed to controversy surrounding…

  5. Moldicidal properties of seven essential oils

    Science.gov (United States)

    Vina W. Yang; Carol A. Clausen

    2006-01-01

    When wood and wood products are exposed to moisture during storage, construction or while in-service, mold growth can occur in 24 to 48 hours. Mold growth could be suppressed or prevented if wood was treated with an effective mold inhibitor. The objective of this study was to evaluate the mold inhibiting properties of natural plant extracts such as essential oils....

  6. 24 CFR 92.356 - Conflict of interest.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Conflict of interest. 92.356... Development HOME INVESTMENT PARTNERSHIPS PROGRAM Other Federal Requirements § 92.356 Conflict of interest. (a... subrecipients, the conflict of interest provisions in 24 CFR 85.36 and 24 CFR 84.42, respectively, apply. In all...

  7. 24 CFR 1003.606 - Conflict of interest.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Conflict of interest. 1003.606... Requirements § 1003.606 Conflict of interest. (a) Applicability. (1) In the procurement of supplies, equipment, construction, and services by grantees and subgrantees, the conflict of interest provisions in 24 CFR 85.36 and...

  8. 24 CFR 585.503 - Conflict of interest.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Conflict of interest. 585.503... § 585.503 Conflict of interest. (a)(1) In addition to the conflict of interest requirements in 24 CFR... the nature of the conflict, accompanied by an assurance that there has been public disclosure of the...

  9. 24 CFR 570.611 - Conflict of interest.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Conflict of interest. 570.611... § 570.611 Conflict of interest. (a) Applicability. (1) In the procurement of supplies, equipment, construction, and services by recipients and by subrecipients, the conflict of interest provisions in 24 CFR 85...

  10. Thalamic glucose metabolism in temporal lobe epilepsy measured with 18F-FDG positron emission tomography (PET)

    NARCIS (Netherlands)

    Khan, N; Leenders, KL; Hajek, M; Maguire, P; Missimer, J; Wieser, HG

    1997-01-01

    Thalamic glucose metabolism has been studied in 24 patients suffering from temporal lobe epilepsy (TLE) using interictal F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET). A total of 17 patients had a unilateral TL seizure onset, 11 of these patients had a mesial temporal lobe

  11. Development and Targeting Efficiency of Irinotecan Engineered ...

    African Journals Online (AJOL)

    Results: The proniosomes were smooth in texture indicating, thin and uniform coating over maltodextrin powder. The highest entrapment efficiency was found for formulation F2 (74.9 ± 2.7 %). The highest cumulative drug release in 24 h was achieved with formulation F3 (98.2 %) In vivo results for the proniosomes reveal ...

  12. Treatment of hypotonous maculopathy after trabeculectomy with mitomycin C

    NARCIS (Netherlands)

    Nuyts, R. M.; Greve, E. L.; Geijssen, H. C.; Langerhorst, C. T.

    1994-01-01

    We treated 34 eyes of 32 patients who developed a hypotonous maculopathy after a trabeculectomy with mitomycin C with various treatment strategies. Placement of a Megasoft Bandage Contact Lens in 24 eyes did not result in a notable increase in intraocular pressure or visual acuity. Intrableb

  13. Recto-sigmoid polypectomy by a handmade snare: Experience of 24 ...

    African Journals Online (AJOL)

    A handmade snare is designed from easily available materials to treat bleeding per rectum in children due to rectosigmoid polyps. A total of 29 polypectomies were done in 24 patients. It is simple, effective, safe and economic. Key words: Bleeding per rectum, children, juvenile polyp, snare polypectomy ...

  14. Legal Frameworks for Higher Education Governance in Sub-Saharan Africa

    Science.gov (United States)

    Saint, William

    2009-01-01

    This is a preliminary survey of the laws and statutes that determine governance arrangements for higher education systems as well as individual institutions in 24 countries of Sub-Saharan Africa. Following an overview of recent higher education governance trends within Africa, it describes the current range of practice and most common approaches…

  15. In vitro anti-viral activity of aqueous extracts of Kenyan Carissa ...

    African Journals Online (AJOL)

    kemrilib

    fibroblast cells cultured in 24 well plates were infected with 1 x 102 PFU 91S HCMV and treated with various concentrations of the extracts. The plaques formed were counted after 7 days incubation at 370C in 5% CO2 and ... their natural habitats in different geographical zones of Kenya. Carissa edulis was collected from.

  16. 48 CFR 52.224-2 - Privacy Act.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Privacy Act. 52.224-2... Act. As prescribed in 24.104, insert the following clause in solicitations and contracts, when the... agency function: Privacy Act (APR 1984) (a) The Contractor agrees to— (1) Comply with the Privacy Act of...

  17. Perceived Mental Illness Stigma among Youth in Psychiatric Outpatient Treatment

    Science.gov (United States)

    Elkington, Katherine S.; Hackler, Dusty; McKinnon, Karen; Borges, Cristiane; Wright, Eric R.; Wainberg, Milton L.

    2012-01-01

    This research explores the experiences of mental illness stigma in 24 youth (58.3% male, 13-24 years, 75% Latino) in psychiatric outpatient treatment. Using Link and Phelan's (2001) model of stigmatization, we conducted thematic analysis of the interview texts, examining experiences of stigma at individual and structural levels, in addition to the…

  18. Eccentric exercise training in patients with chronic obstructive pulmonary disease.

    NARCIS (Netherlands)

    Rooyackers, J.M.; Berkeljon, D.A.; Folgering, H.T.M.

    2003-01-01

    The oxygen cost of eccentric exercise is lower than that of concentric exercise at similar work-loads. In this study, the response to eccentric cycle exercise training (EET) in addition to general exercise training (GET) on exercise performance and quality of life was investigated in 24 patients

  19. Special Education Teacher Time Use in Four Types of Programs

    Science.gov (United States)

    Vannest, Kimberly J.; Hagan-Burke, Shanna; Parker, Richard I.; Soares, Denise A.

    2011-01-01

    The authors examined, by direct observation and 1 hr interval self-reporting, teacher time use in 4 types of special education programs (adaptive behavior units, content mastery, coteaching, resource room). Over 7,000 pieces of data were collected across an academic year from 31 teachers in 24 schools within 9 districts in the Southwestern United…

  20. Effekten af ranitidin på den postoperative monocyt- og neutrofile granulocytfunktion

    DEFF Research Database (Denmark)

    Nielsen, Hans Jørgen; Nielsen, H I; Jensen, S.

    1995-01-01

    The histamine H-2-receptor antagonist ranitidine hydrochloride has been shown to alleviate trauma-, blood transfusion- and sepsis-induced immunosuppression. We evaluated the effect of ranitidine on the postoperative impairment of monocyte and neutrophil function in 24 patients undergoing major...

  1. 24 CFR 597.3 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Definitions. 597.3 Section 597.3... COMMUNITY FACILITIES URBAN EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES: ROUND ONE DESIGNATIONS General Provisions § 597.3 Definitions. The terms HUD and Secretary are defined in 24 CFR part 5. Designation means...

  2. 'n Teoretiese basis vir kontekstualisering in tweetalige woordeboeke*

    African Journals Online (AJOL)

    Mev. R.B. Ruthven

    (b) habeas corp'us, habeas corpus (bevelskrif om 'n gevangene voor die hof te bring). In die artikeldeeltrajek in (24)(a) is dit duidelik dat die vertaalekwivalente wat vir die lemma perceiving aangebied word, van geen kontekstualiserende in- skrywings voorsien is nie.2 Die woordeboekartikel van die lemma percentage.

  3. Thuisdealers, ritselaars en meesnoepers. Bewoners en bezoekers van grootstedelijke crackpanden

    NARCIS (Netherlands)

    Houwing, P.; Oteo Pérez, A.; Korf, D.J.

    2015-01-01

    This article is based on ethnographical research in 24 crack houses in Amsterdam, Rotterdam and The Hague. Crack houses were defined as the homes of crack users where crack is being sold and smoked together with other users. All crack houses were located in disadvantaged, multi-ethnic

  4. National Program for Inspection of Non-Federal Dams. Winsor Dam (MA 00588), Quabbin Spillway (MA 00589), Goodnough Dike (MA 00590), Connecticut River Basin, Ware, Massachusetts. Phase I Inspection Report.

    Science.gov (United States)

    1978-09-01

    prepared under the National Programa for Inspection of Non-Federal Dams. This report is .p4resented for your use and is based upon a visual, inspection, a...in the July 1935 BSCE Journal. Vol. XXI , No. 3, indicates that a runoff of 12 inches in 24 hours would result in a spillway discharge of 9, 000 cfs

  5. Determination of coagulopathy complicating severe preeclampsia ...

    African Journals Online (AJOL)

    Preeclampsia is defined as gestational hypertension plus proteinuria of 300 mg or more in 24 hour urine sample collection or persistent proteinuria of at least 30 mg/dl (at least 1+ on dipstick) in random urine samples.[5] Eclampsia is defined as the onset of seizures and/or unexplained coma during pregnancy, intrapartum.

  6. Gunshot injuries of the spine - a review of 49 cases managed at the ...

    African Journals Online (AJOL)

    The spinal injury was complete in 38 and incomplete in 8, with 3 having no neurological deficit. The level was cervical in 13, thoracic in 24 and lumbar in 12. Only 9 patients improved neurologically. The spine was considered stable in 43 cases. Stabilisation was performed in the 6 unstable cases. The bullets were removed ...

  7. Autonomic neuropathy in nondiabetic offspring of type 2 diabetic subjects is associated with urinary albumin excretion rate and 24-h ambulatory blood pressure: the Fredericia Study

    DEFF Research Database (Denmark)

    Foss, Anne-Catherine; Vestbo, Else; Frøland, Anders

    2001-01-01

    The aim of this study was to examine the impact of parental type 2 diabetes on the autonomic nervous system and to determine whether autonomic neuropathy is present and associated with changes in 24-h ambulatory blood pressure (AMBP) and urinary albumin excretion rate (UAER) in nondiabetic subjec...

  8. 24 CFR 200.635 - Compliance.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Compliance. 200.635 Section 200.635... GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.635 Compliance... Department will enforce compliance through the procedures outlined in 24 CFR part 108. [37 FR 75, Jan. 5...

  9. And justice for all : Examining corruption as a contextual source of mental illness

    NARCIS (Netherlands)

    van Deurzen, I.A.

    2017-01-01

    In the present study, I focus on the relationship between corruption and mental health as measured by the level of depressive symptoms. I use data collected by the European Social Survey in 2006, 2012 and 2014 from 99,159 individuals that lived in 24 European countries. I employ two types of

  10. Evaluation of flavonoids and enterolactone in overnight urine as intake biomarkers of fruits, vegetables and beverages in the Inter99 cohort study using the method of triads

    DEFF Research Database (Denmark)

    Krogholm, Kirstine Suszkiewicz; Bysted, Anette; Brantsaeter, A. L.

    2012-01-01

    in 24 h urine as an alternative and more feasible biomarker of fruit, vegetable and beverage intake. A total of 191 individuals in the Inter99 cohort in Denmark completed the validation study. Concentrations of nine urinary flavonoid aglycones (quercetin, isorhamnetin, tamarixetin, kaempferol...

  11. Stimulus probability and motor response in young and old adults: An ERP study.

    NARCIS (Netherlands)

    de Looren de Jong, H.; Kok, A.; van Rooy, J.C.

    1989-01-01

    Investigated effects of responding hand and stimulus probability in 24 young males (aged 18-24 yrs) and 24 old males (aged 67-75 yrs) subjects in a reaction time (RT) task in which both rare and frequent stimuli required a response. The effect of stimulus probability was less pronounced in old Ss

  12. Evaluation of a semi-quantitative food frequency questionnaire to estimate iodine intake

    DEFF Research Database (Denmark)

    Rasmussen, Lone Banke; Ovesen, L.; Bulow, I.

    2001-01-01

    Objective: To evaluate a food frequency questionnaire (FFQ) used to assess the dietary intake of iodine. Design: The iodine intake determined by the FFQ was compared with 4-day dietary records and with iodine excretion in 24 h urine samples in a subgroup of participants in a cross-sectional study...

  13. Attributing foodborne salmonellosis in humans to animal reservoirs in the European Union using a multi-country stochastic model

    DEFF Research Database (Denmark)

    de Knegt, Leonardo; Pires, Sara Monteiro; Hald, Tine

    2015-01-01

    A Bayesian modelling approach comparing the occurrence of Salmonella serovars in animals and humans was used to attribute salmonellosis cases to broilers, turkeys, pigs, laying hens, travel and outbreaks in 24 European Union countries. Salmonella data for animals and humans, covering the period f......, highlighting differences in the epidemiology of Salmonella, surveillance focus and eating habits across the European Union....

  14. 24 CFR 570.613 - Eligibility restrictions for certain resident aliens.

    Science.gov (United States)

    2010-04-01

    ... certain resident aliens. 570.613 Section 570.613 Housing and Urban Development Regulations Relating to... GRANTS Other Program Requirements § 570.613 Eligibility restrictions for certain resident aliens. (a) Restriction. Certain newly legalized aliens, as described in 24 CFR part 49, are not eligible to apply for...

  15. 77 FR 70799 - Notice of Neighborhood Stabilization Program; Closeout Requirements and Recapture

    Science.gov (United States)

    2012-11-27

    ... to target the stabilization of neighborhoods negatively affected by properties that have been... requirements; (iii) A list of real property held in an NSP-assisted land bank; (iv) If the grantee has assisted... principles described in 24 CFR 570.505 and, for properties held in land banks, the requirement to obligate or...

  16. National immunisation days for polio eradication in Uganda: Did ...

    African Journals Online (AJOL)

    Methods: NIDs for polio eradication commenced in Uganda in 1996. Two rounds, one month apart are implemented yearly. During the second round of 1998 NlDs, cards were introduced nationally and vitamin supplementation was introduced in 24 of the 45 districts. We compared NIDs coverage before and after NIDs cards ...

  17. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Snow and meteorological data (maximum temperature, minimum temperature, fresh snow, fresh snow duration, standing snow) of past 12 winters (1992–2008) have been used to derive the model input variables (average temperature, fresh snow in 24 hrs, snow fall intensity, standing snow, Snow Temperature Index (STI) of ...

  18. Semen Parameters in Infertile Nigerian Males: A critical Study ...

    African Journals Online (AJOL)

    Introduction: Approximately one couple in ten are infertile during their reproductive lives. Male factors alone are responsible for infertility in 24% of couples and contributed to the cause in another 24%. The most important male factor is the semen parameter. Seminal fluid analysis is therefore the cornerstone of male infertility ...

  19. Analysis of biofilm formation and associated gene detection in ...

    African Journals Online (AJOL)

    The objective of this study was to investigate the biofilm-forming ability and distribution of biofilm associated genes in clinically isolated Staphylococcus in bovine mastitis. Silver staining, scanning electron microscopy (SEM) and crystal violet staining were conducted for the detection of biofilmforming ability in 24-well plates.

  20. A Controlled Study of Effect of Counseling on Psychological ...

    African Journals Online (AJOL)

    ... high in 24 (54.9%) respondents in group 2 who had counseling and were unemployed; depression was associated with occupation (P<0.04). Counseling reduces psychological symptoms in people living with HIV/AIDS. Therefore its use should be encouraged in people living with the disease to boost self-esteem needed ...

  1. SAJS SAJS

    African Journals Online (AJOL)

    patients were referred for antiviral therapy. Seven patients declined HIV testing. Imaging of the parotidomegaly was undertaken during the early period of the study; ultrasonography confirmed the cystic nature of the condition in all 30 patients who had this variant of LEL lesion. CT scan was utilised selectively (in 24 patients).

  2. Anaestesirelaterede dødsfald anmeldt til Patientforsikringen i perioden 1996-2004--sekundaerpublikation

    DEFF Research Database (Denmark)

    Hove, Lars Dahlgaard; Steinmetz, Jacob; Christoffersen, Jens Krogh

    2007-01-01

    We investigated the Danish Patient Insurance Association's files on patients registered as dead after a complication to anaesthesia. In 24 cases the patient's death was considered to result from the anesthetic procedure: six deaths were related to airway or ventilation management, four to central...

  3. The Identity of Corporate Ownership in the Industrialized world: Size, industry and country effects

    NARCIS (Netherlands)

    Jong, E. de; Semenov, R.

    2006-01-01

    This paper provides a new and unique dataset, which contains information about ownership, size and industry for 6668 companies in 24 industrial countries. The shares of larger firms are more often widely held or controlled by listed non-financial companies (in particular, widely held companies) and

  4. The Identity of Corporate Ownership in the Industrialized World: Size, Industry and Country Effects

    NARCIS (Netherlands)

    Jong, E. de; Semenov, R.

    2005-01-01

    This paper provides a new and unique dataset, which contains information about ownership, size and industry for 6668 companies in 24 industrial countries. The shares of larger firms are more often widely held or controlled by listed non-financial companies (in particular, widely held companies) and

  5. Headwater streams and forest management: Does ecoregional context influence logging effects on benthic communities?

    Science.gov (United States)

    R. Bruce Medhurst; Mark S. Wipfli; Chris Binckley; Karl Polivka; Paul F. Hessburg; R. Brion. Salter

    2010-01-01

    Effects of forest management on stream communities have been widely documented, but the role that climate plays in the disturbance outcomes is not understood. In order to determine whether the effect of disturbance from forest management on headwater stream communities varies by climate, we evaluated benthic macroinvertebrate communities in 24 headwater streams that...

  6. Improving drug treatment in general practice

    NARCIS (Netherlands)

    Veninga, CCM; Denig, P; Zwaagstra, R; Haaijer-Ruskamp, FM

    In the international Drug Education Project, an educational program involving auditing and feedback in peer groups to improve the treatment of asthma and urinary tract infections (UTI) was developed and tested in primary care. Individualized feedback was provided and discussed in 24 Dutch peer

  7. Tools for characterizing the whole‐cell bio‐oxidation of alkanes at microscale

    DEFF Research Database (Denmark)

    Grant, Chris; da Silva Damas Pinto, Ana Catarina; Lui, Hai‐Po

    2012-01-01

    This article describes the first reported microwell whole‐cell bioconversion using a water immiscible substrate that matches the specific activity and yield achieved in a 1.2 L stirred tank bioreactor. Maximum yields of 0.6 g/Ltotal 1‐dodecanol achieved in 24 h compare favorably to 0.28 g/Ltotal ...

  8. Comparative chemical composition of 24-hour fermented sweet ...

    African Journals Online (AJOL)

    Citrus sinensis) peel meal (24SOFPM) on its chemical composition and performance response to graded levels of peel meal in the diets of pullet chicks. Dry matter, crude protein and phosphorus level in 24SOFPM were close to that of maize.

  9. Plasticity of lifelong calorie-restricted C57BL/6J mice in adapting to a medium-fat diet intervention at old age

    NARCIS (Netherlands)

    Rusli, Fenni; Boekschoten, Mark V.; Borelli, Vincenzo; Sun, Chen; Lute, Carolien; Menke, Aswin L.; Heuvel, van den Joost; Salvioli, Stefano; Franceschi, Claudio; Müller, Michael; Steegenga, Wilma T.

    2017-01-01

    Calorie restriction (CR) is a dietary regimen that supports healthy aging. In this study, we investigated the systemic and liver-specific responses caused by a diet switch to a medium-fat (MF) diet in 24-month-old lifelong, CR-exposed mice. This study aimed to increase the knowledge base on dietary

  10. Long-Term Effects of Preschool Teachers' Book Readings on Low-Income Children's Vocabulary and Story Comprehension.

    Science.gov (United States)

    Dickinson, David K.; Smith, Miriam W.

    1994-01-01

    Finds 3 patterns of book-reading experiences in 24 classrooms of 4-year olds: coconstructive; didactic-interactional; and performance-oriented. Finds larger gains (one year later) by children in the performance-oriented classrooms than by those in the didactic-interactional rooms. Reveals strong effects of child-involved analytic talk on…

  11. Untitled

    Indian Academy of Sciences (India)

    The Intimate Nature of Muscular Contraction 15 technique (Singh and Singh, 1953). In this technique the dying muscle is allowed to relax passively in distilled water or urea solution. After. *imal relaxation in 24 hours, potassium chloride produces further relaxa- tion. If the muscle is allowed to relax actively in distilled water or ...

  12. Implementation of a vascular access quality programme improves vascular access care

    NARCIS (Netherlands)

    van Loon, M.; van der Mark, W.; Beukers, N.; de Bruin, C.; Blankestijn, P. J.; Huisman, R. M.; Zijlstra, J. J.; van der Sande, F. M.; Tordoir, J. H. M.

    Introduction. In the Netherlands an access quality improvement plan (QIP) was introduced by vascular access coordinators (VAC) with the aim to decrease vascular access-related complications by preemptive intervention of malfunctioning accesses. A vascular access QIP was established in 24 centres

  13. Laparoscopic cholecystectomy at the Korle Bu Teaching Hospital ...

    African Journals Online (AJOL)

    The Verres needle was used to obtain pneumoperitoneum in 40 (77%). Only one patient (1.9%) had the operation converted to open cholecystectomy. Most patients, 47/51 (92%), were discharged in 24 hours. The mean durations of various stages were: anaesthesia (110 minutes), pneumo-peritoneum (67.5 minutes) and ...

  14. Security Evaluation and Hardening of Free and Open Source Software (FOSS)

    Science.gov (United States)

    2010-11-01

    security of programs and adopt an aspect-oriented approach to build and develop the solutions. References [1] T. Bollinger . Use of Free and Open-Source...September/October 2000. [16] G. Necula. Proof-Carrying Code. In 24th POPL, pages 106119, Paris, France , January 1997. [17] D. Kozen. Ecient Code

  15. Experiments on prevention of the endotoxin-abortifacient effect by radiodetoxified endotoxin pretreatment in rats

    Energy Technology Data Exchange (ETDEWEB)

    Csordas, T.; Bertok, L.; Csapo, Z.

    1978-01-01

    Endotoxemia has been induced in pregnant rats by intravenous injection of 1 mg Escherichia coli endotoxin which resulted in intrauterine death and abortion of fetuses in 24 h. The abortifacient effect of endotoxin, injected intravenously 24 h earlier. The authors suppose that the radiodetoxified endotoxin can be a good tool also in the prevention of human septic (endotoxin) shock in pregnancy.

  16. Gbore F. A. (18)

    African Journals Online (AJOL)

    grow on maize worldwide, on protein profiles of serum, brain regions and hypophyses were studied in 24 male. Large White weanling pigs ... All the animals were slaughtered and the brains and the hypophyses were carefully dissected out to determine the total ..... in the developing and aging pig brain and hypophyses.

  17. Whipple's operation for carcinoma of the pancreatic head and the ampullary region. Short-and long-term results

    DEFF Research Database (Denmark)

    Sørensen, M B; Banner, Jytte; Rokkjaer, M

    1998-01-01

    In this retrospective review short- and long-term perspectives have been evaluated for 108 patients who, during 1982 through 1992, had Whipple's operation performed for carcinoma of the pancreatic head (PC, n=63) or the ampullary region (AC, n=45). In 24 patients the operation was not radical (21...

  18. Investigation of Galactosylated Low Molecular Weight Chitosan ...

    African Journals Online (AJOL)

    Gal-LMWC(s)-coated liposomes exhibited a maximum of 65 % in vitro drug release in 24 h in a sustained fashion. The 50 % inhibitory concentration (IC50) values for liposomal formulations and drug solution were 2.81 and 5.98 μg/ml, respectively. Conclusion: Gal-LMWC (s) coated liposomes containing DOX that ...

  19. Relative phase stability of bimanual and visuomanual rhythmic coordination patterns in children with a Developmental Coordination Disorder

    NARCIS (Netherlands)

    Volman, M.J.M.; Geuze, R.H.

    A dynamic pattern approach is used to examine the relative phase stability of rhythmic coordination in 24 children with a Developmental Coordination Disorder (DCD) and 24 matched controls in two functionally different tasks - a within-subject task (bimanual coordination) and a subject-environment

  20. Transcutaneous port for levodopa/carbidopa intestinal gel administration in Parkinson's disease

    NARCIS (Netherlands)

    van Laar, T.; Nyholm, D.; Nyman, R.

    Objective - To evaluate the safety and tolerability of the T-Port (R) for intestinal infusion of levodopa/carbidopa gel in patients with advanced Parkinson's disease (PD). Methods - This prospective study was carried out in 24 patients with PD (15 males, mean age 61.8 years, mean duration PD 18.7

  1. Teflon injections in post-prostatectomy incontinence

    DEFF Research Database (Denmark)

    Osther, P J; Røhl, H F

    1988-01-01

    Twenty-five males with post-prostatectomy incontinence due to sphincter damage underwent transperineal or transurethral Teflon injections. The results were classified into three grades: good, moderate, and poor. Good or moderate results were obtained in 24%. No major immediate complications...

  2. 24 CFR 968.110 - Other program requirements.

    Science.gov (United States)

    2010-04-01

    ...-Bacon. With respect to modernization work or contracts over $2,000 (except for nonroutine maintenance work), all laborers and mechanics (other than volunteers under the conditions set out in 24 CFR part 70...). (2) HUD-determined. With respect to all nonroutine maintenance work or contracts, all laborers and...

  3. The (in)consistency of changes in brain macrostructure in male paedophiles

    DEFF Research Database (Denmark)

    Gerwinn, Hannah; Pohl, Alexander; Granert, Oliver

    2015-01-01

    acquired high resolution structural T1-weighted and diffusion MRI scans of the brain in 24 paedophilic and 32 teleiophilic men. We performed voxel-based morphometry (VBM) of the T1-weighted images and tract-based spatial statistics (TBSS) of the diffusion tensor imaging data to search for grey and white...

  4. Low-energy nuclear physics with high-segmentation silicon arrays

    International Nuclear Information System (INIS)

    Betts, R.R.; Univ. of Illinois, Chicago, IL

    1994-01-01

    A brief history is given of silicon detectors leading up to the development of ion-implanted strip detectors. Two examples of their use in low energy nuclear physics are discussed; the search for exotic alpha-chain states in 24 Mg and studies of anomalous positron-electron pairs produced in collisions of very heavy ions

  5. 76 FR 36849 - Adjustment of Civil Money Penalty Amount for Inflation

    Science.gov (United States)

    2011-06-22

    ..., telephone number 202-402-7687 (this is not a toll-free number). Hearing- or speech- impaired individuals may... governments and does not preempt state law within the meaning of the Executive Order. Unfunded Mandates Reform..., or tribal governments or the private sector within the meaning of UMRA. List of Subjects in 24 CFR...

  6. Preparative-scale separation of C60 and C70 on polystyrene gel

    International Nuclear Information System (INIS)

    Guegel, A.; Becker, M.; Hammel, D.; Mindach, L.; Raeder, J.; Simon, T.; Wagner, M.; Muellen, K.

    1992-01-01

    Five grams of a mixture of C 60 /C 70 can be separated in 24 hours by gel permeation chromatography on polystyrene gel. The mobile phase can be completely recovered, and the method can be scaled up by a simple increase in the inner diameter of the column. (orig.) [de

  7. Magnetic Resonance Imaging Volumetric Analysis of the Putamen in Children with ADHD: Combined Type versus Control

    Science.gov (United States)

    Wellington, Tasha McMahon; Semrud-Clikeman, Margaret; Gregory, Amanda Louise; Murphy, Jennifer Mary; Lancaster, Jack Lynn

    2006-01-01

    Objective: Volumetric differences in the putamen of boys with ADHD combined subtype with psychopathic traits and controls are investigated. Method: The putamen in 24 archival magnetic resonance imaging scans of 12 boys in residential treatment with symptoms of ADHD and psychopathic traits and 12 community control boys are analyzed using Display…

  8. Research

    African Journals Online (AJOL)

    abp

    2016-04-15

    Apr 15, 2016 ... gangrenous ileum (48/54, 89%) and gangrenous sigmoid colon (34/46, 74%), while resection and stoma was performed in 8 patients with gangrenous colon. Death occurred in 7 (11.5%) .... to the intensive care unit for continued resuscitation, with a planned second look laparotomy in 24-48 hours, but they ...

  9. Download this PDF file

    African Journals Online (AJOL)

    DR. AMIN

    Gadagi” tea preparations,. “sak'',”sada” and “magani”.. LD50 values of each type of the tea were determined. Results of phase. I and phase II of the study showed no mortality was recorded in any of the experimental groups of rats in 24hours ...

  10. Differential parietal and temporal contributions to music perception in improvising and score-dependent musicians, an fMRI study

    NARCIS (Netherlands)

    Harris, Robert; de Jong, Bauke M.

    2015-01-01

    Using fMRI, cerebral activations were studied in 24 classically-trained keyboard performers and 12 musically unskilled control subjects. Two groups of musicians were recruited: improvising (n=12) and score-dependent (non-improvising) musicians (n=12). While listening to both familiar and unfamiliar

  11. Serotonin 2A Receptors, Citalopram and Tryptophan-Depletion

    DEFF Research Database (Denmark)

    Macoveanu, Julian; Hornboll, Bettina; Elliott, Rebecca

    2013-01-01

    in serotonergic regulation of response inhibition. In 24 healthy adults, we used (18)F-altanserin positron emission tomography to assess cerebral 5-HT(2A) receptors, which have been related to impulsivity. We then investigated the impact of two acute manipulations of brain serotonin levels on behavioral...

  12. Right-Left Approach and Reaching Arm Movements of 4-Month Infants in Free and Constrained Conditions

    Science.gov (United States)

    Morange-Majoux, Francoise; Dellatolas, Georges

    2010-01-01

    Recent theories on the evolution of language (e.g. Corballis, 2009) emphazise the interest of early manifestations of manual laterality and manual specialization in human infants. In the present study, left- and right-hand movements towards a midline object were observed in 24 infants aged 4 months in a constrained condition, in which the hands…

  13. Short psychodynamic supportive psychotherapy, antidepressants, and their combination in the treatment of major depression: A mega-analysis based on three randomized clinical trials

    NARCIS (Netherlands)

    de Maat, S.C.M.; Dekker, J.J.M.; Schoevers, R.A.; van Aalst, G.; Natijk, C.G.; Hendriksen, M.; Kool, S.; Peen, J.; Van, R.; de Jonghe, F.

    2008-01-01

    The efficacy of Short Psychodynamic Supportive Psychotherapy (SPSP) has not yet been compared with pharmacotherapy. A mega-analysis based on three original Randomized Clinical Trials (RCTs) was performed. Patients with (mild to moderate) major depressive disorder were randomized in (24 weeks) SPSP

  14. Development and experimental results from a 1 kW prototype AMR

    DEFF Research Database (Denmark)

    Bahl, Christian R.H.; Engelbrecht, Kurt; Eriksen, Dan

    2014-01-01

    A novel rotary magnetic refrigeration device has been designed and constructed following the concepts recently outlined in Bahl et al. (2011). The magnet and flow system design allow for almost continuous usage of both the magnetic field and the magnetocaloric material in 24 cassettes, each...

  15. Development and Experimental Results from a 1 kW Prototype AMR

    DEFF Research Database (Denmark)

    Bahl, Christian; Engelbrecht, Kurt; Eriksen, Dan

    2012-01-01

    A novel rotary magnetic refrigeration device has been designed and constructed following the concepts recently outlined in Bahl et al. (2011). The magnet and flow system design allow for almost continuous usage of both the magnetic field and the magnetocaloric material in 24 cassettes, each...

  16. Prediction of local and metastatic recurrence in solitary fibrous tumor: construction of a risk calculator in a multicenter cohort from the French Sarcoma Group (FSG) database

    NARCIS (Netherlands)

    Salas, S.; Resseguier, N.; Blay, J.Y.; Cesne, A. Le; Italiano, A.; Chevreau, C.; Rosset, P.; Isambert, N.; Soulie, P.; Cupissol, D.; Delcambre, C.; Bay, J.O.; Dubray-Longeras, P.; Krengli, M.; Bari, B. De; Villa, S.; Kaanders, J.H.A.M.; Torrente, S.; Pasquier, D.; Thariat, J.O.; Myroslav, L.; Sole, C.V.; Dincbas, H.F.; Habboush, J.Y.; Zilli, T.; Dragan, T.; Khan, R.K.; Ugurluer, G.; Cena, T.; Duffaud, F.; Penel, N.; Bertucci, F.; Ranchere-Vince, D.; Terrier, P.; Bonvalot, S.; Macagno, N.; Lemoine, C.; Lae, M.; Coindre, J.M.; Bouvier, C.

    2017-01-01

    Background: Solitary fibrous tumors (SFT) are rare unusual ubiquitous soft tissue tumors that are presumed to be of fibroblastic differentiation. At present, the challenge is to establish accurate prognostic factors. Patients and methods: A total of 214 consecutive patients with SFT diagnosed in 24

  17. Follow-up of conservatively treated sleep apnoea patients

    African Journals Online (AJOL)

    1994-06-17

    Jun 17, 1994 ... Med Hyg 1990; 84: 277-282. 13. Maisonneuve H, Zribi M. Peyran F. A pediatric suspension of albendazole in the ... syndrome (SAHS).3 However, many other symptoms may be reported. . Diagnostic problems .... such as hypertension and asthma were predominant in 24% of patients. Only 6% of patients ...

  18. Pupil Migration in the New York City Public Schools, 1956-1957 to 1965-1966.

    Science.gov (United States)

    Morrissey, Madeline M.; Zouzoulas, Gary

    A statistical report provides data from 1956 to 1966 on city-wide in-and-out-migration, the migration balance, and the total city-wide movement of the pupil population in New York City. Findings are presented in 24 tables. (NH)

  19. 77 FR 28741 - The Housing and Economic Recovery Act of 2008 (HERA): Changes to the Section 8 Tenant-Based...

    Science.gov (United States)

    2012-05-15

    ... inclusion of cooperative housing under Sec. 983.2(b) and Sec. 983.2(c)(7)(ii) is outdated. Additionally... inclusion of this requirement in 24 CFR 983.211 will eliminate any possible ambiguity about the application..., need not choose between the elderly or disabled families, but may give a preference to both...

  20. Dealing with difficult library clients- perspectives from Nigerian ...

    African Journals Online (AJOL)

    This work examined difficult client situations in Federal Government funded Libraries in Nigerian. 124 librarians working in 24 federal government funded libraries in Nigeria participated in the study. Random sampling was used to select libraries that part icipated in the library. Questionnaire was used for data gathering.

  1. 24 CFR 886.307 - Physical condition standards; physical inspection requirements.

    Science.gov (United States)

    2010-04-01

    ..., subpart G. (b) Space and security. In addition to the standards in 24 CFR part 5, subpart G, the dwelling unit must have a living room, a kitchen area, and a bathroom. The dwelling unit must have at least one...) The unit shall contain suitable space to store, prepare and serve foods in a sanitary manner. A...

  2. Efficacy of Atomoxetine for the Treatment of ADHD Symptoms in Patients with Pervasive Developmental Disorders: A Prospective, Open-Label Study

    Science.gov (United States)

    Fernandez-Jaen, Alberto; Fernandez-Mayoralas, Daniel Martin; Calleja-Perez, Beatriz; Munoz-Jareno, Nuria; Campos Diaz, Maria del Rosario; Lopez-Arribas, Sonia

    2013-01-01

    Objective: Atomoxetine's tolerance and efficacy were studied in 24 patients with pervasive developmental disorder and symptoms of ADHD. Method: Prospective, open-label, 16-week study was performed, using the variables of the Clinical Global Impression Scale and the Conners' Scale, among others. Results: A significant difference was found between…

  3. Changes in energy metabolism in response to 48 h of overfeeding and fasting in Caucasians and Pima Indians

    DEFF Research Database (Denmark)

    Weyer, C; Vozarova, B; Ravussin, E

    2001-01-01

    Differences in the metabolic response to overfeeding and starvation may confer susceptibility or resistance to obesity in humans. To further examine this hypothesis, we assessed the changes in 24 h energy metabolism in response to short-term overfeeding and fasting in Caucasians (C) and Pima...

  4. Effect of growth hormone replacement therapy on plasma lecithin : cholesterol acyltransferase and lipid transfer protein activities in growth hormone-deficient adults

    NARCIS (Netherlands)

    Beentjes, JAM; van Tol, A; Sluiter, WJ; Dullaart, RPF

    The effects of growth hormone (GH) replacement on plasma lecithin:cholesterol acyltransferase (LCAT), cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP), factors involved in high density lipoprotein (HDL) metabolism, We unknown. We carried out a 6 mouths study in 24

  5. Frequent hypermethylation of DBC1 in malignant lymphoproliferative neoplasms

    DEFF Research Database (Denmark)

    Grønbæk, Karin Elmegård; Ralfkiaer, U.; Dahl, C.

    2008-01-01

    follicular lymphomas, 5 of 5 mantle cell lymphomas, 4 of 4 small lymphocytic lymphomas, 1 of 2 lymphoplasmacytoid lymphomas, and in 12 of 12 acute lymphoblastic leukemias, but was unmethylated in 1 case of splenic marginal zone lymphoma, in 12 of 12 multiple myelomas, in 24 of 24 reactive lymph nodes...

  6. Immunogenetics of rheumatoid arthritis and primary Sjögren's syndrome: DNA polymorphism of HLA class II genes

    DEFF Research Database (Denmark)

    Morling, Niels; Andersen, V; Fugger, L

    1992-01-01

    We investigated the DNA restriction fragment length polymorphism (RFLP) of the Major Histocompatability Complex (MHC) class II genes: HLA-DRB, -DQA, -DQB, DPA, and -DFB in 24 patients with rheumatoid arthritis (RA), in 19 patients with primary Sjögren's syndrome (primary SS), and healthy Danes. T...

  7. HLA-DP antigens in patients with alopecia areata

    DEFF Research Database (Denmark)

    Ødum, Niels; Morling, N; Georgsen, J

    1990-01-01

    The distribution of HLA-DP antigens were studied in 41 patients with alopecia areata (AA) and 188 ethnically matched controls. An increase of DR4 and possibly DR5 in 24 of these patients has previously been reported. HLA-DP typing for DPw1 through w6 and the local specificity, CDP HEI, was perfor...

  8. Generation of Soluble Receptor Activator of NF-KappaB Ligand Is Critical for Osteolytic Bone Metastasis

    Science.gov (United States)

    2010-10-01

    mature, TRAP-positive multinucleated cells were counted as osteoclasts. BD BioCoat Osteologic Coverslips (BD Biosciences) were placed in 24-well plates...by counting the number of calcium phosphate matrix resorption pits formed per BD BioCoat Osteologic Coverslip. Commercially available sRANKL (positive

  9. Gonadic function in workmen with long-term exposure to microwaves

    Energy Technology Data Exchange (ETDEWEB)

    Lancranjan, I.; Maicanescu, M.; Rafaila, E.; Klepsch, I.; Popescu, H.I.

    1975-09-01

    Thity-one technicians (mean exposure 8 years) were investigated by questionnaire, semen analysis, and determination of 17-ketosteroids and gonadotropin in 24-h urine. Libido was decreased in 22 subjects and 23 showed disorders of spermatogenesis. A direct effect of microwaves on the germinal epithelium appeared probable.

  10. Preliminary in vitro and in vivo characterizations of a sol–gel derived ...

    Indian Academy of Sciences (India)

    Unknown

    The in vitro cell culture studies with L929 mouse fibroblast cell line showed very few cells adhered on the BGS disc after 24 h. .... This study characterizes the physical properties such as the crystallinity and surface morphology of the sol– ... well) were seeded in 24-well tissue culture polystyrene plates enriched in Dulbecco's ...

  11. Decolorization of dyes by recombinase CotA from Escherichia coli ...

    African Journals Online (AJOL)

    The CotA laccase could efficiently decolorize anthraquinone and azo dyes in 24 h. The decolourization capacity of this recombinant laccase suggested that it could be a useful biocatalyst for the treatment of dye-containing effluents. Key words: Recombinant CotA laccase, Escherichia coli, purification, dye decolorization.

  12. Allergic contact dermatitis from methyldibromo glutaronitrile--clinical cases from 2003

    DEFF Research Database (Denmark)

    Zachariae, C; Johansen, J D; Rastogi, Suresh Chandra

    2005-01-01

    to be of relevance. Among these, 27 had hand eczema, with a relevant exposure predominantly from wash-off products, either liquid soaps or shampoos, in 24 patients. Following identification of the allergen by patch testing and subsequent avoidance of products containing MDBGN, the hand eczema either improved...

  13. Effects of land use/cover change and harvests on forest carbon dynamics in northern states of the United States from remote sensing and inventory data: 1992-2001

    Science.gov (United States)

    Daolan Zheng; Linda S. Heath; Mark J. Ducey; James E. Smith

    2011-01-01

    We examined spatial patterns of changes in forest area and nonsoil carbon (C) dynamics affected by land use/cover change (LUC) and harvests in 24 northern states of the United States using an integrated methodology combining remote sensing and ground inventory data between 1992 and 2001. We used the Retrofit Change Product from the Multi-Resolution Land Characteristics...

  14. Reevaluation of the criteria for the clinical diagnosis of Gitelman syndrome.

    NARCIS (Netherlands)

    Ring, T.; Knoers, N.V.A.M.; Oh, M.S.; Halperin, M.L.

    2002-01-01

    A 16-year-old female had mutations in both alleles of the gene encoding her sodium-chloride cotransporter; one of these mutations is newly described. Her clinical findings were not typical because of the absence of hypocalciuria in 24-h urine samples, her maximum urine osmolality (U(osm)) was only

  15. The effects of controlled intake of selected protein foods on ...

    African Journals Online (AJOL)

    reduction in 24–hour urine output; these were greatest in NR placed on diet F and lowest in those on diets E and B. Blood urea and serum creatinine levels of NR on diet E were significantly lower (pC>A>D>F. In conclusion, this study has shown that cooked egg white ...

  16. Scholarly Productivity in Communication Studies: Five-Year Review 2012-2016

    Science.gov (United States)

    Griffin, Darrin J.; Bolkan, San; Dahlbach, Barbara J.

    2018-01-01

    This study reports prolific scholarship trends in communication studies based on individual publication rates in 24 journals from the field for the years 2012-2016. In addition, we summarized data from a subset of journals considered to be most central to our discipline ("Human Communication Research, Communication Research, Communication…

  17. Revealing genome-scale transcriptional regulatory landscape of OmpR highlights its expanded regulatory roles under osmotic stress in Escherichia coli K-12 MG1655

    DEFF Research Database (Denmark)

    Seo, Sang Woo; Gao, Ye; Kim, Donghyuk

    2017-01-01

    A transcription factor (TF), OmpR, plays a critical role in transcriptional regulation of the osmotic stress response in bacteria. Here, we reveal a genome-scale OmpR regulon in Escherichia coli K-12 MG1655. Integrative data analysis reveals that a total of 37 genes in 24 transcription units (TUs...

  18. 24 CFR 200.3 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... Requirements for Existing Projects § 200.3 Definitions. (a) The definitions “Department”, “Elderly person”, “HUD”, and “Secretary”, as used in this subpart A shall have the meanings given these definitions in 24... “state”, as used in this subpart A shall have the meaning given in the section of the National Housing...

  19. 24 CFR 882.802 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... in 24 CFR part 5 and § 882.102 (except for the definition of “Single Room Occupancy (SRO) Housing...) OFFICE OF THE ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND... SUPPORTIVE HOUSING FOR THE ELDERLY PROGRAM AND SECTION 811 SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES...

  20. 24 CFR 945.105 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... FAMILIES General § 945.105 Definitions. The terms Department, Elderly person, HUD, NAHA, Public Housing... respect to dwellings as set forth in the second definition of “accessible” in 24 CFR 8.3. Allocation plan.... Designated family means the category of family for whom the project is designated (e. g., elderly family in a...