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Sample records for in-line micro four-point

  1. High precision micro-scale Hall Effect characterization method using in-line micro four-point probes

    DEFF Research Database (Denmark)

    Petersen, Dirch Hjorth; Hansen, Ole; Lin, Rong

    2008-01-01

    and experimental measurements, that the repeatability of a micro-scale Hall effect measurement is better than 1 %. We demonstrate the ability to spatially resolve Hall effect on micro-scale by characterization of an USJ with a single laser stripe anneal. The micro sheet resistance variations resulting from...

  2. Fundamental size limitations of micro four-point probes

    DEFF Research Database (Denmark)

    Ansbæk, Thor; Petersen, Dirch Hjorth; Hansen, Ole

    2009-01-01

    -scaled as well in order to correctly characterize the extremely thin films used. This presents a four-point probe design and fabrication challenge. We analyze the fundamental limitation on down-scaling of a generic micro four-point probe (M4PP) in a comprehensive study, where mechanical, thermal, and electrical...

  3. Micro-four-point Probe Hall effect Measurement method

    DEFF Research Database (Denmark)

    Petersen, Dirch Hjorth; Hansen, Ole; Lin, Rong

    2008-01-01

    barriers and with a magnetic field applied normal to the plane of the sheet. Based on this potential, analytical expressions for the measured four-point resistance in presence of a magnetic field are derived for several simple sample geometries. We show how the sheet resistance and Hall effect......We report a new microscale Hall effect measurement method for characterization of semiconductor thin films without need for conventional Hall effect geometries and metal contact pads. We derive the electrostatic potential resulting from current flow in a conductive filamentary sheet with insulating...... contributions may be separated using dual configuration measurements. The method differs from conventional van der Pauw measurements since the probe pins are placed in the interior of the sample region, not just on the perimeter. We experimentally verify the method by micro-four-point probe measurements...

  4. Sensitivity study of micro four-point probe measurements on small samples

    DEFF Research Database (Denmark)

    Wang, Fei; Petersen, Dirch Hjorth; Hansen, Torben Mikael

    2010-01-01

    The authors calculate the sensitivities of micro four-point probe sheet resistance and Hall effect measurements to the local transport properties of nonuniform material samples. With in-line four-point probes, the measured dual configuration sheet resistance is more sensitive near the inner two...... probes than near the outer ones. The sensitive area is defined for infinite film, circular, square, and rectangular test pads, and convergent sensitivities are observed for small samples. The simulations show that the Hall sheet resistance RH in micro Hall measurements with position error suppression...

  5. Junction leakage measurements with micro four-point probes

    DEFF Research Database (Denmark)

    Lin, Rong; Petersen, Dirch Hjorth; Wang, Fei;

    2012-01-01

    We present a new, preparation-free method for measuring the leakage current density on ultra-shallow junctions. The junction leakage is found by making a series of four-point sheet resistance measurements on blanket wafers with variable electrode spacings. The leakage current density is calculated...... using a fit of the measured four-point resistances to an analytical two-sheet model. The validity of the approximation involved in the two-sheet model is verified by a comparison to finite element model calculations....

  6. Junction leakage measurements with micro four-point probes

    DEFF Research Database (Denmark)

    Lin, Rong; Petersen, Dirch Hjorth; Wang, Fei

    2012-01-01

    We present a new, preparation-free method for measuring the leakage current density on ultra-shallow junctions. The junction leakage is found by making a series of four-point sheet resistance measurements on blanket wafers with variable electrode spacings. The leakage current density is calculate...

  7. Review of electrical characterization of ultra-shallow junctions with micro four-point probes

    DEFF Research Database (Denmark)

    Petersen, Dirch Hjorth; Hansen, Ole; Hansen, Torben M.;

    2010-01-01

    techniques will become even more evident. In several recent studies micro four-point probe (M4PP) has been demonstrated as a reliable high precision metrology method for both sheet resistance and Hall effect measurements of ultra-shallow implants and has revealed a promising potential for carrier profiling....

  8. Direct measurement of resistance of multiwalled carbon nanotubes using micro four-point probes

    DEFF Research Database (Denmark)

    Dohn, Søren; Mølhave, Kristian; Bøggild, Peter

    2005-01-01

    The electrical properties of multiwalled carbon nanotubes was investigated by micro four point probes, fabricated using conventional silicon microfabrication techniques. After positioning of chemical vapour deposition-grown multi-walled carbon nanotubes on a SiO2 substrate, the two- or four-point...... resistance at specific positions along the nanotubes, was measured by microprobes with different microelectrocle spacings. Individual nanotubes were investigated in more detail by measuring current as a function of bias voltage until the point of failure and the results are compared to previously reported...

  9. Accuracy of micro four-point probe measurements on inhomogeneous samples: A probe spacing dependence study

    DEFF Research Database (Denmark)

    Wang, Fei; Petersen, Dirch Hjorth; Østerberg, Frederik Westergaard

    2009-01-01

    In this paper, we discuss a probe spacing dependence study in order to estimate the accuracy of micro four-point probe measurements on inhomogeneous samples. Based on sensitivity calculations, both sheet resistance and Hall effect measurements are studied for samples (e.g. laser annealed samples...... the probe spacing is smaller than 1/40 of the variation wavelength, micro four-point probes can provide an accurate record of local properties with less than 1% measurement error. All the calculations agree well with previous experimental results.......) with periodic variations of sheet resistance, sheet carrier density, and carrier mobility. With a variation wavelength of ¿, probe spacings from 0.0012 to 1002 have been applied to characterize the local variations. The calculations show that the measurement error is highly dependent on the probe spacing. When...

  10. Accuracy of micro four-point probe measurements on inhomogeneous samples: A probe spacing dependence study

    OpenAIRE

    Wang, Fei; Petersen, Dirch Hjorth; Østerberg, Frederik Westergaard; Hansen, Ole

    2009-01-01

    In this paper, we discuss a probe spacing dependence study in order to estimate the accuracy of micro four-point probe measurements on inhomogeneous samples. Based on sensitivity calculations, both sheet resistance and Hall effect measurements are studied for samples (e.g. laser annealed samples) with periodic variations of sheet resistance, sheet carrier density, and carrier mobility. With a variation wavelength of ¿, probe spacings from 0.0012 to 1002 have been applied to characterize the ...

  11. Advanced carrier depth profiling on Si and Ge with micro four-point probe

    DEFF Research Database (Denmark)

    Clarysse, Trudo; Eyben, Pierre; Parmentier, Brigitte

    2008-01-01

    In order to reach the ITRS goals for future complementary metal-oxide semiconductor technologies, there is a growing need for the accurate extraction of ultrashallow electrically active dopant (carrier) profiles. In this work, it will be illustrated that this need can be met by the micro four......-point probe (M4PP) tool. M4PP sheet resistance measurements taken along beveled Si and Ge blanket shallow structures will be investigated. From the differential sheet resistance changes, the underlying carrier profile can be reconstructed without the need to rely on a complicated contact modeling, i.e., M4PP...... carrier profiling is an absolute carrier depth profiling technique. On Si, it is found that the more sensitive a structure is to carrier spilling along the bevel, the better the M4PP system performs relative to conventional spreading resistance probe (SRP) due to its much lower probe pressure...

  12. Fast and direct measurements of the electrical properties of graphene using micro four-point probes.

    Science.gov (United States)

    Klarskov, M B; Dam, H F; Petersen, D H; Hansen, T M; Löwenborg, A; Booth, T J; Schmidt, M S; Lin, R; Nielsen, P F; Bøggild, P

    2011-11-04

    We present measurements of the electronic properties of graphene using a repositionable micro four-point probe system, which we show here to have unique advantages over measurements made on lithographically defined devices; namely speed, simplicity and lack of a need to pattern graphene. Measurements are performed in ambient, vacuum and controlled environmental conditions using an environmental scanning electron microscope (SEM). The results are comparable to previous results for microcleaved graphene on silicon dioxide (SiO(2)). We observe a pronounced hysteresis of the charge neutrality point, dependent on the sweep rate of the gate voltage; and environmental measurements provide insight into the sensor application prospects of graphene. The method offers a fast, local and non-destructive technique for electronic measurements on graphene, which can be positioned freely on a graphene flake.

  13. Electronic transport at semiconductor surfaces - from point-contact transistor to micro-four-point probes

    DEFF Research Database (Denmark)

    Hasegawa, S.; Grey, Francois

    2002-01-01

    show that this type of conduction is measurable using new types of experimental probes, such as the multi-tip scanning tunnelling microscope and the micro-four-point probe. The resulting electronic transport properties are intriguing, and suggest that semiconductor surfaces should be considered......The electrical properties of semiconductor surfaces have played a decisive role in one of the most important discoveries of the last century, transistors. In the 1940s, the concept of surface states-new electron energy levels characteristic of the surface atoms-was instrumental in the fabrication...... of the first point-contact transistors, and led to the successful fabrication of field-effect transistors. However, to this day, one property of semiconductor surface states remains poorly understood, both theoretically and experimentally. That is the conduction of electrons or holes directly through...

  14. Fast and direct measurements of the electrical properties of graphene using micro four-point probes

    DEFF Research Database (Denmark)

    Klarskov, Mikkel Buster; Dam, Henrik Friis; Petersen, Dirch Hjorth

    2011-01-01

    . Measurements are performed in ambient, vacuum and controlled environmental conditions using an environmental scanning electron microscope (SEM). The results are comparable to previous results for microcleaved graphene on silicon dioxide (SiO2). We observe a pronounced hysteresis of the charge neutrality point......We present measurements of the electronic properties of graphene using a repositionable micro four-point probe system, which we show here to have unique advantages over measurements made on lithographically defined devices; namely speed, simplicity and lack of a need to pattern graphene......, dependent on the sweep rate of the gate voltage; and environmental measurements provide insight into the sensor application prospects of graphene. The method offers a fast, local and non-destructive technique for electronic measurements on graphene, which can be positioned freely on a graphene flake....

  15. Nanobits, Nembranes and Micro Four-Point Probes: Customizable Tools for insitu Manipulation and Characterisation of Nanostructures

    DEFF Research Database (Denmark)

    Bøggild, Peter; Petersen, Dirch Hjorth; Sardan Sukas, Özlem;

    2010-01-01

    on a cantilever; (ii) scanning micro four point probes allow fast, non- destructive mapping of local electrical properties (sheet resistance and Hall mobility) and hysteresis effects of graphene sheets; (iii) sub 100 nm freestanding devices with wires, heaters, actuators, sensors, resonators and probes were...... defined in a 100 nm thin membrane with focused ion beam milling. By patterning generic membrane templates (Nembranes) the fabrication time of a TEM compatible NEMS device is effectively reduced to less around 20 minutes....

  16. Micro-four-point probes in a UHV scanning electron microscope for in-situ surface-conductivity measurements

    DEFF Research Database (Denmark)

    Shiraki, I.; Nagao, T.; Hasegawa, S.;

    2000-01-01

    For in-situ measurements of surface conductivity in ultrahigh vacuum (UHV), we have installed micro-four-point probes (probe spacings down to 4 mum) in a UHV scanning electron microscope (SEM) combined with scanning reflection-high-energy electron diffraction (RHEED). With the aid of piezoactuators...... for precise positioning of the probes, local conductivity of selected surface domains of well-defined superstructures could be measured during SEM and RHEED observations. It was found that the surface sensitivity of the conductivity measurements was enhanced by reducing the probe spacing, enabling...

  17. Electrically continuous graphene from single crystal copper verified by terahertz conductance spectroscopy and micro four-point probe.

    Science.gov (United States)

    Buron, Jonas D; Pizzocchero, Filippo; Jessen, Bjarke S; Booth, Timothy J; Nielsen, Peter F; Hansen, Ole; Hilke, Michael; Whiteway, Eric; Jepsen, Peter U; Bøggild, Peter; Petersen, Dirch H

    2014-11-12

    The electrical performance of graphene synthesized by chemical vapor deposition and transferred to insulating surfaces may be compromised by extended defects, including for instance grain boundaries, cracks, wrinkles, and tears. In this study, we experimentally investigate and compare the nano- and microscale electrical continuity of single layer graphene grown on centimeter-sized single crystal copper with that of previously studied graphene films, grown on commercially available copper foil, after transfer to SiO2 surfaces. The electrical continuity of the graphene films is analyzed using two noninvasive conductance characterization methods: ultrabroadband terahertz time-domain spectroscopy and micro four-point probe, which probe the electrical properties of the graphene film on different length scales, 100 nm and 10 μm, respectively. Ultrabroadband terahertz time-domain spectroscopy allows for measurement of the complex conductance response in the frequency range 1-15 terahertz, covering the entire intraband conductance spectrum, and reveals that the conductance response for the graphene grown on single crystalline copper intimately follows the Drude model for a barrier-free conductor. In contrast, the graphene grown on commercial copper foil shows a distinctly non-Drude conductance spectrum that is better described by the Drude-Smith model, which incorporates the effect of preferential carrier backscattering associated with extended, electronic barriers with a typical separation on the order of 100 nm. Micro four-point probe resistance values measured on graphene grown on single crystalline copper in two different voltage-current configurations show close agreement with the expected distributions for a continuous 2D conductor, in contrast with previous observations on graphene grown on commercial copper foil. The terahertz and micro four-point probe conductance values of the graphene grown on single crystalline copper shows a close to unity correlation, in

  18. Development of micro-four-point probe in a scanning tunneling microscope for in situ electrical transport measurement

    Energy Technology Data Exchange (ETDEWEB)

    Ge, Jian-Feng; Liu, Zhi-Long; Gao, Chun-Lei; Qian, Dong; Liu, Canhua, E-mail: canhualiu@sjtu.edu.cn, E-mail: jfjia@sjtu.edu.cn; Jia, Jin-Feng, E-mail: canhualiu@sjtu.edu.cn, E-mail: jfjia@sjtu.edu.cn [Key Laboratory of Artificial Structures and Quantum Control (Ministry of Education), Department of Physics and Astronomy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240 (China)

    2015-05-15

    Electrons at surface may behave differently from those in bulk of a material. Multi-functional tools are essential in comprehensive studies on a crystal surface. Here, we developed an in situ microscopic four-point probe (4PP) transport measurement system on the basis of a scanning tunneling microscope (STM). In particular, convenient replacement between STM tips and micro-4PPs enables systematic investigations of surface morphology, electronic structure, and electrical transport property of a same sample surface. Performances of the instrument are demonstrated with high-quality STM images, tunneling spectra, and low-noise electrical I-V characteristic curves of a single-layer FeSe film grown on a conductive SrTiO{sub 3} surface.

  19. Development of micro-four-point probe in a scanning tunneling microscope for in situ electrical transport measurement.

    Science.gov (United States)

    Ge, Jian-Feng; Liu, Zhi-Long; Gao, Chun-Lei; Qian, Dong; Liu, Canhua; Jia, Jin-Feng

    2015-05-01

    Electrons at surface may behave differently from those in bulk of a material. Multi-functional tools are essential in comprehensive studies on a crystal surface. Here, we developed an in situ microscopic four-point probe (4PP) transport measurement system on the basis of a scanning tunneling microscope (STM). In particular, convenient replacement between STM tips and micro-4PPs enables systematic investigations of surface morphology, electronic structure, and electrical transport property of a same sample surface. Performances of the instrument are demonstrated with high-quality STM images, tunneling spectra, and low-noise electrical I-V characteristic curves of a single-layer FeSe film grown on a conductive SrTiO3 surface.

  20. Characterization of positional errors and their influence on micro four-point probe measurements on a 100 nm Ru film

    DEFF Research Database (Denmark)

    Kjær, Daniel; Hansen, Ole; Østerberg, Frederik Westergaard;

    2015-01-01

    Thin-film sheet resistance measurements at high spatial resolution and on small pads are important and can be realized with micrometer-scale four-point probes. As a result of the small scale the measurements are affected by electrode position errors. We have characterized the electrode position...... errors in measurements on Ru thin film using an Au-coated 12-point probe. We show that the standard deviation of the static electrode position error is on the order of 5 nm, which significantly affects the results of single configuration measurements. Position-error-corrected dual......-configuration measurements, however, are shown to eliminate the effect of position errors to a level limited either by electrical measurement noise or dynamic position errors. We show that the probe contact points remain almost static on the surface during the measurements (measured on an atomic scale) with a standard...

  1. Anisotropy in conductance of a quasi-one-dimensional metallic surface state measured by a square micro-four-point probe method.

    Science.gov (United States)

    Kanagawa, Taizo; Hobara, Rei; Matsuda, Iwao; Tanikawa, Takehiro; Natori, Akiko; Hasegawa, Shuji

    2003-07-18

    We have devised a "square micro-four-point probe method" using an independently driven ultrahigh-vacuum four-tip scanning tunneling microscope, and succeeded for the first time to directly measure anisotropic electrical conductance of a single-atomic layer on a solid surface. A quasi-one-dimensional metal of a single-domain Si(111)4 x 1-In had a surface-state conductance along the metallic atom chains (sigma(axially)) to be 7.2(+/-0.6) x 10(-4) S/square at room temperature, which was larger than that in the perpendicular direction (sigma(radially)) by approximately 60 times. The sigma(axially) was consistently interpreted by a Boltzmann equation with the anisotropic surface-state band dispersion, while the sigma(radially) was dominated by a surface-space-charge-layer conductance.

  2. Comparative study of size dependent four-point probe sheet resistance measurement on laser annealed ultra-shallow junctions

    DEFF Research Database (Denmark)

    Petersen, Dirch Hjorth; Lin, Rong; Hansen, Torben Mikael;

    2008-01-01

    In this comparative study, the authors demonstrate the relationship/correlation between macroscopic and microscopic four-point sheet resistance measurements on laser annealed ultra-shallow junctions (USJs). Microfabricated cantilever four-point probes with probe pitch ranging from 1.5 to 500 mu m...... have been used to characterize the sheet resistance uniformity of millisecond laser annealed USJs. They verify, both experimentally and theoretically, that the probe pitch of a four-point probe can strongly affect the measured sheet resistance. Such effect arises from the sensitivity (or "spot size......") of an in-line four-point probe. Their study shows the benefit of the spatial resolution of the micro four-point probe technique to characterize stitching effects resulting from the laser annealing process....

  3. Four-Point Wavelets and Their Applications

    Institute of Scientific and Technical Information of China (English)

    魏国富; 陈发来

    2002-01-01

    Multiresolution analysis (MRA) and wavelets provide useful and efficient tools for representing functions at multiple levels of details. Wavelet representations have been used in a broad range of applications, including image compression, physical simulation and numerical analysis. In this paper, the authors construct a new class of wavelets, called four-point wavelets,based on an interpolatory four-point subdivision scheme. They are of local support, symmetric and stable. The analysis and synthesis algorithms have linear time complexity. Depending on different weight parameters w, the scaling functions and wavelets generated by the four-point subdivision scheme are of different degrees of smoothness. Therefore the user can select better wavelets relevant to the practice among the classes of wavelets. The authors apply the fourpoint wavelets in signal compression. The results show that the four-point wavelets behave much better than B-spline wavelets in many situations.

  4. In-line phase contrast micro-CT reconstruction for biomedical specimens.

    Science.gov (United States)

    Fu, Jian; Tan, Renbo

    2014-01-01

    X-ray phase contrast micro computed tomography (micro-CT) can non-destructively provide the internal structure information of soft tissues and low atomic number materials. It has become an invaluable analysis tool for biomedical specimens. Here an in-line phase contrast micro-CT reconstruction technique is reported, which consists of a projection extraction method and the conventional filter back-projection (FBP) reconstruction algorithm. The projection extraction is implemented by applying the Fourier transform to the forward projections of in-line phase contrast micro-CT. This work comprises a numerical study of the method and its experimental verification using a biomedical specimen dataset measured at an X-ray tube source micro-CT setup. The numerical and experimental results demonstrate that the presented technique can improve the imaging contrast of biomedical specimens. It will be of interest for a wide range of in-line phase contrast micro-CT applications in medicine and biology.

  5. Scanning microscopic four-point conductivity probes

    DEFF Research Database (Denmark)

    Petersen, Christian Leth; Hansen, Torben Mikael; Bøggild, Peter

    2002-01-01

    A method for fabricating microscopic four-point probes is presented. The method uses silicon-based microfabrication technology involving only two patterning steps. The last step in the fabrication process is an unmasked deposition of the conducting probe material, and it is thus possible to select...... the conducting material either for a silicon wafer or a single probe unit. Using shadow masking photolithography an electrode spacing (pitch) down to 1.1 mum was obtained, with cantilever separation down to 200 run. Characterisation measurements have shown the microscopic probes to be mechanically very flexible...

  6. In-line measurement of transparent micro membranes

    DEFF Research Database (Denmark)

    Fugl, Jimmy; Hansen, Hans Nørgaard; De Chiffre, Leonardo

    2007-01-01

    The purpose of this work has been to develop a new measuring principle to bring down the time for quality assurance, and obtain larger uniformity of the end product, in a specific production line. The production concerns thin transparent micro membranes (approx 35 micron thickness) dispensed...... in micro cavities, each membrane consisting of several membrane layers. A quality control should be performed every time a new layer is dispensed. The paper describes a new way of measuring membrane thickness. The method was achieved through the use of a vision system, whereby the thickness of the thin...... transparent micro membrane is determined in terms of the light absorbance of the membrane substrate. The new and faster measuring method makes is possible to measure the thickness of individual membranes and perform a 100% quality control....

  7. In-line measurement of transparent micro membranes

    DEFF Research Database (Denmark)

    Fugl, Jimmy; Hansen, Hans Nørgaard; De Chiffre, Leonardo

    2007-01-01

    The purpose of this work has been to develop a new measuring principle to bring down the time for quality assurance, and obtain larger uniformity of the end product, in a specific production line. The production concerns thin transparent micro membranes (approx 35 micron thickness) dispensed...... in micro cavities, each membrane consisting of several membrane layers. A quality control should be performed every time a new layer is dispensed. The paper describes a new way of measuring membrane thickness. The method was achieved through the use of a vision system, whereby the thickness of the thin...... transparent micro membrane is determined in terms of the light absorbance of the membrane substrate. The new and faster measuring method makes is possible to measure the thickness of individual membranes and perform a 100% quality control....

  8. Four point bending setup for characterization of semiconductor piezoresistance

    DEFF Research Database (Denmark)

    Richter, Jacob; Arnoldus, Morten Berg; Hansen, Ole

    2008-01-01

    We present a four point bending setup suitable for high precision characterization of piezoresistance in semiconductors. The compact setup has a total size of 635 cm3. Thermal stability is ensured by an aluminum housing wherein the actual four point bending fixture is located. The four point...... bending fixture is manufactured in polyetheretherketon and a dedicated silicon chip with embedded piezoresistors fits in the fixture. The fixture is actuated by a microstepper actuator and a high sensitivity force sensor measures the applied force on the fixture and chip. The setup includes heaters...

  9. Tessellating cushions: four-point functions in N=4 SYM

    CERN Document Server

    Eden, Burkhard

    2016-01-01

    We consider a class of planar tree-level four-point functions in N=4 SYM in a special kinematic regime: one BMN operator with two scalar excitations and three half-BPS operators are put onto a line in configuration space; additionally, for the half-BPS operators a co-moving frame is chosen in flavour space. In configuration space, the four-punctured sphere is naturally triangulated by tree-level planar diagrams. We demonstrate on a number of examples that each tile can be associated with a modified hexagon form-factor in such a way as to efficiently reproduce the tree-level four-point function. Our tessellation is not of the OPE type, fostering the hope of finding an independent, integrability-based approach to the computation of planar four-point functions.

  10. A laboratory on the four-point probe technique

    Science.gov (United States)

    Schuetze, Andrew P.; Lewis, Wayne; Brown, Chris; Geerts, Wilhelmus J.

    2004-02-01

    We describe how a classic electrostatics experiment can be modified to be a four-point probe lab experiment. Students use the four-point probe technique to investigate how the measured resistance varies as a function of the position of the electrodes with respect to the edge of the sample. By using elementary electromagnetism concepts such as the superposition principle, the continuity equation, the relation between electric field and electric potential, and Ohm's law, a simple model is derived to describe the four-point probe technique. Although the lab introduces the students to the ideas behind the Laplace equation and the methods of images, advanced mathematics is avoided so that the experiment can be done in trigonometry and algebra based physics courses. In addition, the experiment introduces the students to a standard measurement technique that is widely used in industry and thus provides them with useful hands-on experience.

  11. Four-point function in the IOP matrix model

    Science.gov (United States)

    Michel, Ben; Polchinski, Joseph; Rosenhaus, Vladimir; Suh, S. Josephine

    2016-05-01

    The IOP model is a quantum mechanical system of a large- N matrix oscillator and a fundamental oscillator, coupled through a quartic interaction. It was introduced previously as a toy model of the gauge dual of an AdS black hole, and captures a key property that at infinite N the two-point function decays to zero on long time scales. Motivated by recent work on quantum chaos, we sum all planar Feynman diagrams contributing to the four-point function. We find that the IOP model does not satisfy the more refined criteria of exponential growth of the out-of-time-order four-point function.

  12. Four-point function in the IOP matrix model

    CERN Document Server

    Michel, Ben; Rosenhaus, Vladimir; Suh, S Josephine

    2016-01-01

    The IOP model is a quantum mechanical system of a large-$N$ matrix oscillator and a fundamental oscillator, coupled through a quartic interaction. It was introduced previously as a toy model of the gauge dual of an AdS black hole, and captures a key property that at infinite $N$ the two-point function decays to zero on long time scales. Motivated by recent work on quantum chaos, we sum all planar Feynman diagrams contributing to the four-point function. We find that the IOP model does not satisfy the more refined criteria of exponential growth of the out-of-time-order four-point function.

  13. Femtosecond laser fabricated in-line micro multicavity fiber FP interferometers sensor

    Science.gov (United States)

    Tian, Ming; Lu, Ping; Chen, Li; Liu, Deming; Yang, Minghong; Zhang, Jiangshan

    2014-04-01

    A compact micro multicavity Fabry-Perot (FP) optical fiber tip sensor is presented. In the end of the single-mode fiber (SMF), we drill a short air hole with femtosecond laser, which forms a multicavity together with the fiber flat face tip. The sensor has been experimentally tested for refractive index (RI) and temperature sensing by monitoring its wavelength shift. Simultaneous measurement of both changes in the ambient temperature and the RI can be realized using the sensitivity matrix. Measurement results show that the in-line FP exhibits the gas RI sensitivity of 867.76 nm/RIU and the temperature sensitivity of 7.8 pm/°C within the range of 24-104 °C, and the device is highly stable over time.

  14. In-line characterization and identification of micro-droplets on-chip

    Directory of Open Access Journals (Sweden)

    Weber Emanuel

    2014-01-01

    Full Text Available We present an integrated optofluidic sensor system for in-line characterization of micro-droplets. The device provides information about the droplet generation frequency, the droplet volume, and the content of the droplet. Due to its simplicity this principle can easily be implemented with other microfluidic components on one and the same device. The sensor is based on total internal reflection phenomena. Droplets are pushed through a microfluidic channel which is hit by slightly diverging monochromatic light. At the solid-liquid interface parts of the rays experience total internal reflection while another part is transmitted. The ratio of reflected to transmitted light depends on the refractive index of the solution. Both signals are recorded simultaneously and provide a very stable output signal for the droplet characterization. With the proposed system passing droplets were counted up to 320 droplets per second and droplets with different volumes could be discriminated. In a final experiment droplets with different amounts of dissolved CaCl2 were distinguished based on their reflected and transmitted light pattern. This principle can be applied for the detection of any molecules in microdroplets which significantly influence the refractive index of the buffer solution.

  15. Magic identities for conformal four-point integrals

    CERN Document Server

    Drummond, J M; Smirnov, V A; Sokatchev, E S

    2007-01-01

    We propose an iterative procedure for constructing classes of off-shell four-point conformal integrals which are identical. The proof of the identity is based on the conformal properties of a subintegral common for the whole class. The simplest example are the so-called `triple scalar box' and `tennis court' integrals. In this case we also give an independent proof using the method of Mellin--Barnes representation which can be applied in a similar way for general off-shell Feynman integrals.

  16. Open-Source Automated Mapping Four-Point Probe

    Directory of Open Access Journals (Sweden)

    Handy Chandra

    2017-01-01

    Full Text Available Scientists have begun using self-replicating rapid prototyper (RepRap 3-D printers to manufacture open source digital designs of scientific equipment. This approach is refined here to develop a novel instrument capable of performing automated large-area four-point probe measurements. The designs for conversion of a RepRap 3-D printer to a 2-D open source four-point probe (OS4PP measurement device are detailed for the mechanical and electrical systems. Free and open source software and firmware are developed to operate the tool. The OS4PP was validated against a wide range of discrete resistors and indium tin oxide (ITO samples of different thicknesses both pre- and post-annealing. The OS4PP was then compared to two commercial proprietary systems. Results of resistors from 10 to 1 MΩ show errors of less than 1% for the OS4PP. The 3-D mapping of sheet resistance of ITO samples successfully demonstrated the automated capability to measure non-uniformities in large-area samples. The results indicate that all measured values are within the same order of magnitude when compared to two proprietary measurement systems. In conclusion, the OS4PP system, which costs less than 70% of manual proprietary systems, is comparable electrically while offering automated 100 micron positional accuracy for measuring sheet resistance over larger areas.

  17. Open-Source Automated Mapping Four-Point Probe.

    Science.gov (United States)

    Chandra, Handy; Allen, Spencer W; Oberloier, Shane W; Bihari, Nupur; Gwamuri, Jephias; Pearce, Joshua M

    2017-01-26

    Scientists have begun using self-replicating rapid prototyper (RepRap) 3-D printers to manufacture open source digital designs of scientific equipment. This approach is refined here to develop a novel instrument capable of performing automated large-area four-point probe measurements. The designs for conversion of a RepRap 3-D printer to a 2-D open source four-point probe (OS4PP) measurement device are detailed for the mechanical and electrical systems. Free and open source software and firmware are developed to operate the tool. The OS4PP was validated against a wide range of discrete resistors and indium tin oxide (ITO) samples of different thicknesses both pre- and post-annealing. The OS4PP was then compared to two commercial proprietary systems. Results of resistors from 10 to 1 MΩ show errors of less than 1% for the OS4PP. The 3-D mapping of sheet resistance of ITO samples successfully demonstrated the automated capability to measure non-uniformities in large-area samples. The results indicate that all measured values are within the same order of magnitude when compared to two proprietary measurement systems. In conclusion, the OS4PP system, which costs less than 70% of manual proprietary systems, is comparable electrically while offering automated 100 micron positional accuracy for measuring sheet resistance over larger areas.

  18. Face pose tracking using the four-point algorithm

    Science.gov (United States)

    Fung, Ho Yin; Wong, Kin Hong; Yu, Ying Kin; Tsui, Kwan Pang; Kam, Ho Chuen

    2017-06-01

    In this paper, we have developed an algorithm to track the pose of a human face robustly and efficiently. Face pose estimation is very useful in many applications such as building virtual reality systems and creating an alternative input method for the disabled. Firstly, we have modified a face detection toolbox called DLib for the detection of a face in front of a camera. The detected face features are passed to a pose estimation method, known as the four-point algorithm, for pose computation. The theory applied and the technical problems encountered during system development are discussed in the paper. It is demonstrated that the system is able to track the pose of a face in real time using a consumer grade laptop computer.

  19. Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography

    Science.gov (United States)

    Nesterets, Yakov; Gureyev, Tim; Stevenson, Andrew; Pogany, Andrew; Wilkins, Steve; Kincaid, Russell; Ye, Hongwei; Vogelsang, Levon; Lipson, Edward; Coman, Ioana; Fourmaux, Sylvain; Kieffer, Jean-Claude; Krol, Andrzej

    2008-03-01

    To assess the feasibility of small soft tissue avascular tumor micro-CT imaging with x-ray phase-contrast in-line holography, we have studied micro-CT imaging with in-line geometry of small spheroidal avascular tumor models with quiescent cell core (< 250 μm) and various distributions of the proliferating cell density (PCD) forming the outer shell. We have simulated imaging with an ultrafast laser-based x-ray source with a Mo target. We observe phase-contrast enhancement of the tumor boundaries in the reconstructed transaxial images, resulting in improved detection of small soft tissue tumors, providing that the PCD density gradient is sufficiently large.

  20. Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography

    Science.gov (United States)

    Nesterets, Yakov; Gureyev, Tim; Stevenson, Andrew; Pogany, Andrew; Wilkins, Steve; Kincaid, Russell; Ye, Hongwei; Vogelsang, Levon; Lipson, Edward; Coman, Ioana; Fourmaux, Sylvain; Kieffer, Jean-Claude; Krol, Andrzej

    2009-01-01

    To assess the feasibility of small soft tissue avascular tumor micro-CT imaging with x-ray phase-contrast in-line holography, we have studied micro-CT imaging with in-line geometry of small spheroidal avascular tumor models with quiescent cell core (< 250 μm) and various distributions of the proliferating cell density (PCD) forming the outer shell. We have simulated imaging with an ultrafast laser-based x-ray source with a Mo target. We observe phase-contrast enhancement of the tumor boundaries in the reconstructed transaxial images, resulting in improved detection of small soft tissue tumors, providing that the PCD density gradient is sufficiently large. PMID:20052303

  1. Stiffness identification of four-point-elastic-support rigid plate

    Institute of Scientific and Technical Information of China (English)

    彭利平; 刘初升; 武继达; 王帅

    2015-01-01

    As the stiffness of the elastic support varies with the physical-chemical erosion and mechanical friction, model catastrophe of a single degree-of-freedom (DOF) isolation system may occur. A 3-DOF four-point-elastic-support rigid plate (FERP) structure is presented to describe the catastrophic isolation system. Based on the newly-established structure, theoretical derivation for stiffness matrix calculation by free response (SMCbyFR) and the method of stiffness identification by stiffness matrix disassembly (SIbySMD) are proposed. By integrating the SMCbyFR and the SIbySMD and defining the stiffness assurance criterion (SAC), the procedures for stiffness identification of a FERP structure (SIFERP) are summarized. Then, a numerical example is adopted for the SIFERP validation, in which the simulated tested free response data are generated by the numerical methods, and operation for filtering noise is conducted to imitate the practical application. Results in the numerical example demonstrate the feasibility and accuracy of the developed SIFERP for stiffness identification.

  2. Photonic Low Cost Micro-Sensor for in-Line Wear Particle Detection in Flowing Lube Oils

    Directory of Open Access Journals (Sweden)

    Jon Mabe

    2017-03-01

    Full Text Available The presence of microscopic particles in suspension in industrial fluids is often an early warning of latent or imminent failures in the equipment or processes where they are being used. This manuscript describes work undertaken to integrate different photonic principles with a micro- mechanical fluidic structure and an embedded processor to develop a fully autonomous wear debris sensor for in-line monitoring of industrial fluids. Lens-less microscopy, stroboscopic illumination, a CMOS imager and embedded machine vision technologies have been merged to develop a sensor solution that is able to detect and quantify the number and size of micrometric particles suspended in a continuous flow of a fluid. A laboratory test-bench has been arranged for setting up the configuration of the optical components targeting a static oil sample and then a sensor prototype has been developed for migrating the measurement principles to real conditions in terms of operating pressure and flow rate of the oil. Imaging performance is quantified using micro calibrated samples, as well as by measuring real used lubricated oils. Sampling a large fluid volume with a decent 2D spatial resolution, this photonic micro sensor offers a powerful tool at very low cost and compacted size for in-line wear debris monitoring.

  3. Photonic Low Cost Micro-Sensor for in-Line Wear Particle Detection in Flowing Lube Oils

    Science.gov (United States)

    Mabe, Jon; Zubia, Joseba; Gorritxategi, Eneko

    2017-01-01

    The presence of microscopic particles in suspension in industrial fluids is often an early warning of latent or imminent failures in the equipment or processes where they are being used. This manuscript describes work undertaken to integrate different photonic principles with a micro- mechanical fluidic structure and an embedded processor to develop a fully autonomous wear debris sensor for in-line monitoring of industrial fluids. Lens-less microscopy, stroboscopic illumination, a CMOS imager and embedded machine vision technologies have been merged to develop a sensor solution that is able to detect and quantify the number and size of micrometric particles suspended in a continuous flow of a fluid. A laboratory test-bench has been arranged for setting up the configuration of the optical components targeting a static oil sample and then a sensor prototype has been developed for migrating the measurement principles to real conditions in terms of operating pressure and flow rate of the oil. Imaging performance is quantified using micro calibrated samples, as well as by measuring real used lubricated oils. Sampling a large fluid volume with a decent 2D spatial resolution, this photonic micro sensor offers a powerful tool at very low cost and compacted size for in-line wear debris monitoring. PMID:28335436

  4. Electrical four-point probing of spherical metallic thin films coated onto micron sized polymer particles

    Energy Technology Data Exchange (ETDEWEB)

    Pettersen, Sigurd R., E-mail: sigurd.r.pettersen@ntnu.no, E-mail: jianying.he@ntnu.no; Stokkeland, August Emil; Zhang, Zhiliang; He, Jianying, E-mail: sigurd.r.pettersen@ntnu.no, E-mail: jianying.he@ntnu.no [NTNU Nanomechanical Lab, Department of Structural Engineering, Norwegian University of Science and Technology (NTNU), NO-7491 Trondheim (Norway); Kristiansen, Helge [NTNU Nanomechanical Lab, Department of Structural Engineering, Norwegian University of Science and Technology (NTNU), NO-7491 Trondheim (Norway); Conpart AS, Dragonveien 54, NO-2013 Skjetten (Norway); Njagi, John; Goia, Dan V. [Center for Advanced Materials Processing, Clarkson University, Potsdam, New York 13699-5814 (United States); Redford, Keith [Conpart AS, Dragonveien 54, NO-2013 Skjetten (Norway)

    2016-07-25

    Micron-sized metal-coated polymer spheres are frequently used as filler particles in conductive composites for electronic interconnects. However, the intrinsic electrical resistivity of the spherical thin films has not been attainable due to deficiency in methods that eliminate the effect of contact resistance. In this work, a four-point probing method using vacuum compatible piezo-actuated micro robots was developed to directly investigate the electric properties of individual silver-coated spheres under real-time observation in a scanning electron microscope. Poly(methyl methacrylate) spheres with a diameter of 30 μm and four different film thicknesses (270 nm, 150 nm, 100 nm, and 60 nm) were investigated. By multiplying the experimental results with geometrical correction factors obtained using finite element models, the resistivities of the thin films were estimated for the four thicknesses. These were higher than the resistivity of bulk silver.

  5. Dynamic Carrying Capacity Analysis of Double-Row Four-Point Contact Ball Slewing Bearing

    Directory of Open Access Journals (Sweden)

    Yunfeng Li

    2015-01-01

    Full Text Available Carrying capacity is the most important performance index for slewing bearings. Maximizing the carrying capacity of slewing bearing is one pursuing goal for the bearing designer; this is usually realized by optimizing the design parameters. A method of analyzing the carrying capacity of double-row four-point contact ball slewing bearing by using dynamic carrying capacity surfaces was proposed in this paper. Based on the dynamic load carrying capacity surface of the slewing bearing, the effect of changes of the bearing design parameters, such as axial clearance, raceway groove radius coefficient, and contact angle, on the dynamic carrying capacity of the slewing bearing was researched; the trend and the degree of the effect of the micro changes of the bearing design parameters on the dynamic load carrying capacity of the bearing were discussed, and the results provide the basis for optimizing the design parameter of this type of slewing bearing.

  6. EXISTENCE FOR SECOND-ORDER FOUR-POINT BOUNDARY VALUE PROBLEM AT RESONANCE

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    This paper is concerned with the existence of solutions for a second-order four-point boundary value problem at resonance. The main methods depend on the technique of the upper and lower solutions and the coincidence degree theory.

  7. Resolution enhancement of scanning four-point-probe measurements on two-dimensional systems

    DEFF Research Database (Denmark)

    Hansen, Torben Mikael; Stokbro, Kurt; Hansen, Ole;

    2003-01-01

    A method to improve the resolution of four-point-probe measurements of two-dimensional (2D) and quasi-2D systems is presented. By mapping the conductance on a dense grid around a target area and postprocessing the data, the resolution can be improved by a factor of approximately 50 to better than 1....../15 of the four-point-probe electrode spacing. The real conductance sheet is simulated by a grid of discrete resistances, which is optimized by means of a standard optimization algorithm, until the simulated voltage-to-current ratios converges with the measurement. The method has been tested against simulated...... data as well as real measurements and is found to successfully deconvolute the four-point-probe measurements. In conjunction with a newly developed scanning four-point probe with electrode spacing of 1.1 µm, the method can resolve the conductivity with submicron resolution. ©2003 American Institute...

  8. Is Abdominal Muscle Activity Different from Lumbar Muscle Activity during Four-Point Kneeling?

    OpenAIRE

    Soraya Pirouzi; Farahnaz Emami; Shohreh Taghizadeh; Ali Ghanbari

    2013-01-01

    Background: Stabilization exercises can improve the performance of trunk and back muscles, which are effective in the prevention and treatment of low back pain. The four-point kneeling exercise is one of the most common types of stabilization exercises. This quasi-experimental study aimed to evaluate and compare the level of activation between abdominal and lumbar muscles in the different stages of the four-point kneeling exercise. Methods: The present study was conducted on 30 healthy wom...

  9. Conductivity of individual particles measured by a microscopic four-point-probe method

    OpenAIRE

    Ling Sun; Jianjun Wang; Elmar Bonaccurso

    2013-01-01

    We introduce a technique for measuring the conductivity of individual hybrid metal, semiconducting core-shell and full-metal conducting particles by a microscopic four-point probe (μ-4PP) method. The four-point probe geometry allows for minimizing contact resistances between electrodes and particles. By using a focused ion beam we fabricate platinum nanoleads between four microelectrodes on a silicon chip and an individual particle, and determine the particle's conductivity via sensitive curr...

  10. Mesoscopic current transport in two-dimensional materials with grain boundaries: Four-point probe resistance and Hall effect

    Science.gov (United States)

    Lotz, Mikkel R.; Boll, Mads; Østerberg, Frederik W.; Hansen, Ole; Petersen, Dirch H.

    2016-10-01

    We have studied the behavior of micro four-point probe (M4PP) measurements on two-dimensional (2D) sheets composed of grains of varying size and grain boundary resistivity by Monte Carlo based finite element (FE) modelling. The 2D sheet of the FE model was constructed using Voronoi tessellation to emulate a polycrystalline sheet, and a square sample was cut from the tessellated surface. Four-point resistances and Hall effect signals were calculated for a probe placed in the center of the square sample as a function of grain density n and grain boundary resistivity ρ GB . We find that the dual configuration sheet resistance as well as the resistance measured between opposing edges of the square sample have a simple unique dependency on the dimension-less parameter √{ n } ρ GB G 0 , where G0 is the sheet conductance of a grain. The value of the ratio R A / R B between resistances measured in A- and B-configurations depends on the dimensionality of the current transport (i.e., one- or two-dimensional). At low grain density or low grain boundary resistivity, two-dimensional transport is observed. In contrast, at moderate grain density and high grain resistivity, one-dimensional transport is seen. Ultimately, this affects how measurements on defective systems should be interpreted in order to extract relevant sample parameters. The Hall effect response in all M4PP configurations was only significant for moderate grain densities and fairly large grain boundary resistivity.

  11. Mesoscopic current transport in two-dimensional materials with grain boundaries: Four-point probe resistance and Hall effect

    DEFF Research Database (Denmark)

    Lotz, Mikkel Rønne; Boll, Mads; Østerberg, Frederik Westergaard

    2016-01-01

    We have studied the behavior of micro four-point probe (M4PP) measurements on two-dimensional (2D) sheets composed of grains of varying size and grain boundary resistivity by Monte Carlo based finite element (FE) modelling. The 2D sheet of the FE model was constructed using Voronoi tessellation......-configurations depends on the dimensionality of the current transport (i.e., one- or two-dimensional). At low grain density or low grain boundary resistivity, two-dimensional transport is observed. In contrast, at moderate grain density and high grain resistivity, one-dimensional transport is seen. Ultimately......, this affects how measurements on defective systems should be interpreted in order to extract relevant sample parameters. The Hall effect response in all M4PP configurations was only significant for moderate grain densities and fairly large grain boundary resistivity....

  12. Resolution enhancement of scanning four-point-probe measurements on two-dimensional systems.

    OpenAIRE

    Hansen, Torben Mikael; Stokbro, Kurt; Hansen, Ole; Hassenkam, T.; Shiraki, I.; Hasegawa, S.; Bøggild, Peter

    2003-01-01

    A method to improve the resolution of four-point-probe measurements of two-dimensional (2D) and quasi-2D systems is presented. By mapping the conductance on a dense grid around a target area and postprocessing the data, the resolution can be improved by a factor of approximately 50 to better than 1/15 of the four-point-probe electrode spacing. The real conductance sheet is simulated by a grid of discrete resistances, which is optimized by means of a standard optimization algorithm, until the ...

  13. Electrical conduction through surface superstructures measured by microscopic four-point probes

    DEFF Research Database (Denmark)

    Hasegawa, S.; Shiraki, I.; Tanabe, F.

    2003-01-01

    For in-situ measurements of the local electrical conductivity of well-defined crystal surfaces in ultra-high vacuum, we have developed two kinds of microscopic four-point probe methods. One involves a "four-tip STM prober," in which four independently driven tips of a scanning tunneling microscope...

  14. Direct measurement of surface-state conductance by microscopic four-point probe method

    DEFF Research Database (Denmark)

    Hasegawa, S.; Shiraki, I.; Tanikawa, T.

    2002-01-01

    For in situ measurements of local electrical conductivity of well defined crystal surfaces in ultrahigh vacuum, we have developed microscopic four-point probes with a probe spacing of several micrometres, installed in a scanning-electron - microscope/electron-diffraction chamber. The probe...

  15. Developing Multidimensional Likert Scales Using Item Factor Analysis: The Case of Four-Point Items

    Science.gov (United States)

    Asún, Rodrigo A.; Rdz-Navarro, Karina; Alvarado, Jesús M.

    2016-01-01

    This study compares the performance of two approaches in analysing four-point Likert rating scales with a factorial model: the classical factor analysis (FA) and the item factor analysis (IFA). For FA, maximum likelihood and weighted least squares estimations using Pearson correlation matrices among items are compared. For IFA, diagonally weighted…

  16. Design of a miniature electrolyte conductivity probe using ISFETs in a four point configuration

    NARCIS (Netherlands)

    Volanschi, A.; Olthuis, W.; Bergveld, P.

    1994-01-01

    In this work the design, fabrication and testing of a four point electrode configuration based on ISFETs for the measurement of electrolytic conductivity are presented. The final design uses a distance between the ISFET gates of only 100 ¿m allowing a chip area in contact with the electrolyte of 2.2

  17. The conductivity of Bi(111) investigated with nanoscale four point probes

    DEFF Research Database (Denmark)

    Wells, J.W.; Handrup, K.; Kallehauge, J.F.;

    2008-01-01

    The room temperature conductance of Bi(111) was measured using microscopic four point probes with a contact spacing down to 500 nm. The conductance is remarkably similar to that of the bulk, indicating that surface scattering is not a major mechanism for restricting the mobility at this length...

  18. Degradation Assessment in IGBT Modules Using Four-Point Probing Approach

    DEFF Research Database (Denmark)

    Pedersen, Kristian Bonderup; Kristensen, Peter Kjær; Popok, Vladimir;

    2015-01-01

    Four-point probing of electrical parameters on various components of IGBT modules is suggested as an approach for the estimation of degradation in stressed devices. By comparison of these parameters for stressed and new components one can evaluate an overall degradation of the module and find out...

  19. Bubble shape and orientation determination with a four-point optical fibre probe

    NARCIS (Netherlands)

    Guet, S.; Luther, S.; Ooms, G.

    2003-01-01

    We propose a new method to estimate the aspect ratio and orientation of bubbles by using their time series obtained with a four-point optical-fibre probe. The feasibility and accuracy of the method was first analysed by using synthetic bubble–probe interaction data and single bubble experiments in p

  20. Symmetric point four-point functions at one loop in QCD

    Science.gov (United States)

    Gracey, J. A.

    2017-03-01

    We evaluate the quartic ghost and quark Green's functions as well as the gluon-ghost, gluon-quark and ghost-quark four-point functions of quantum chromodynamics at one loop at the fully symmetric point in a linear covariant gauge. Similar expressions for the analogous Green's functions in quantum electrodynamics are also provided.

  1. Existence of Solutions for Nonlinear Four-Point -Laplacian Boundary Value Problems on Time Scales

    Directory of Open Access Journals (Sweden)

    Topal SGulsan

    2009-01-01

    Full Text Available We are concerned with proving the existence of positive solutions of a nonlinear second-order four-point boundary value problem with a -Laplacian operator on time scales. The proofs are based on the fixed point theorems concerning cones in a Banach space. Existence result for -Laplacian boundary value problem is also given by the monotone method.

  2. Ultrasound-guided bilateral dual transversus abdominis plane block: a new four-point approach

    DEFF Research Database (Denmark)

    Neimann, Jens Dupont Børglum; Maschmann, C; Belhage, B;

    2011-01-01

    Background: We describe a new ultrasound-guided bilateral dual transversus abdominis plane block. Our hypothesis was that we could anaesthetize both the upper (Th6–Th9) and the lower (Th10–Th12) abdominal wall bilaterally using a four-point single-shot technique to provide effective post-operativ......Background: We describe a new ultrasound-guided bilateral dual transversus abdominis plane block. Our hypothesis was that we could anaesthetize both the upper (Th6–Th9) and the lower (Th10–Th12) abdominal wall bilaterally using a four-point single-shot technique to provide effective post...... scale 0–10) from a mean of 8.2 to a mean of 2.2 10 min after block performance (P

  3. Experimental and Theoretical Deflections of Hybrid Composite Sandwich Panel under Four-point Bending Load

    Directory of Open Access Journals (Sweden)

    Jauhar Fajrin

    2017-03-01

    Full Text Available This paper presents a comparison of theoretical and experimental deflection of a hybrid sandwich panel under four-point bending load. The paper initially presents few basic equations developed under three-point load, followed by development of model under four-point bending load and a comparative analysis between theoretical and experimental results. It was found that the proposed model for predicting the deflection of hybrid sandwich panels provided fair agreement with the experimental values. Most of the sandwich panels showed theoretical deflection values higher than the experimental values, which is desirable in the design. It was also noticed that the introduction of intermediate layer does not contribute much to reduce the deflection of sandwich panel as the main contributor for the total deflection was the shear deformation of the core that mostly determined by the geometric of the samples and the thickness of the core.

  4. Conductivity of individual particles measured by a microscopic four-point-probe method.

    Science.gov (United States)

    Sun, Ling; Wang, Jianjun; Bonaccurso, Elmar

    2013-01-01

    We introduce a technique for measuring the conductivity of individual hybrid metal, semiconducting core-shell and full-metal conducting particles by a microscopic four-point probe (μ-4PP) method. The four-point probe geometry allows for minimizing contact resistances between electrodes and particles. By using a focused ion beam we fabricate platinum nanoleads between four microelectrodes on a silicon chip and an individual particle, and determine the particle's conductivity via sensitive current and voltage measurements. Up to sixteen particles can be taken up by each chip, which allows for multiple conductivity measurements by simply multiplexing the electric contacts connected to a multimeter. Although, for demonstration, we used full Au (conducting) and Ag-coated latex particles (semiconducting) of a few micrometers in diameter, the method can be applied to other types of conducting or semiconducting particles of different diameters.

  5. Four-point correlation function of stress-energy tensors in N=4 superconformal theories

    CERN Document Server

    Korchemsky, G P

    2015-01-01

    We derive the explicit expression for the four-point correlation function of stress-energy tensors in four-dimensional N=4 superconformal theory. We show that it has a remarkably simple and suggestive form allowing us to predict a large class of four-point correlation functions involving the stress-energy tensor and other conserved currents. We then apply the obtained results on the correlation functions to computing the energy-energy correlations, which measure the flow of energy in the final states created from the vacuum by a source. We demonstrate that they are given by a universal function independent of the choice of the source. Our analysis relies only on N=4 superconformal symmetry and does not use the dynamics of the theory.

  6. Four-point bending test of the Bauschinger effect in prestrained IF steel thin sheet

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Hiroyuki, E-mail: hkato@eng.hokudai.ac.jp [Mechanical and Space Engineering, Hokkaido University, Sapporo 060-8628 (Japan); Sasaki, Kazuaki [Mechanical and Space Engineering, Hokkaido University, Sapporo 060-8628 (Japan); Mori, T. [National Defense Academy, Yokosuka 239-0811 (Japan)

    2015-08-26

    The Bauschinger effect in a 1 mm thick sheet of interstitial free (IF) steel was examined by tensile testing (prestraining) and subsequent four-point bending. The effect was absent when the prestrain was below 4% and was present when the prestrain was above 4%. The Bauschinger effect parameter determined the elastic back stress which developed after prestraining. The occurrence of back stress coincided with the development of dislocation cell structures, observed with transmission electron microscopy.

  7. On the ABJM four-point amplitude at three loops and BDS exponentiation

    Science.gov (United States)

    Bianchi, Marco S.; Leoni, Matias

    2014-11-01

    We study the three-loop four-point amplitude in ABJM theory. We determine the dual conformal invariant integrals with highest number of propagators and fix their coefficients by two-particle cuts. Evaluating such a combination of integrals in dimensional regularization we provide evidence for exponentiation of the amplitude, including the finite terms. In addition we show that the three-loop amplitude can be expressed in terms of classical polylogarithms of uniform degree of transcendentality.

  8. On the ABJM four-point amplitude at three loops and BDS exponentiation

    CERN Document Server

    Bianchi, Marco S

    2014-01-01

    We study the three-loop four-point amplitude in ABJM theory. We determine the dual conformal invariant integrals with highest number of propagators and fix their coefficients by two-particle cuts. Evaluating such a combination of integrals in dimensional regularization we provide evidence for exponentiation of the amplitude, including the finite terms. In addition we show that the three-loop amplitude can be expressed in terms of classical polylogarithms of uniform degree of transcendentality.

  9. Lengthscale dependence of dynamic four-point susceptibilities in glass formers

    OpenAIRE

    Chandler, David; Juan P Garrahan; Jack, Robert L.; Maibaum, Lutz; Pan, Albert C.

    2006-01-01

    Dynamical four-point susceptibilities measure the extent of spatial correlations in the dynamics of glass forming systems. We show how these susceptibilities depend on the length scales that necessarily form part of their definition. The behaviour of these susceptibilities is estimated by means of an analysis in terms of renewal processes within the context of dynamic facilitation. The analytic results are confirmed by numerical simulations of an atomistic model glass-former, and of two kinet...

  10. Fourth-Order Four-Point Boundary Value Problem: A Solutions Funnel Approach

    Directory of Open Access Journals (Sweden)

    Panos K. Palamides

    2012-01-01

    Full Text Available We investigate the existence of positive or a negative solution of several classes of four-point boundary-value problems for fourth-order ordinary differential equations. Although these problems do not always admit a (positive Green's function, the obtained solution is still of definite sign. Furthermore, we prove the existence of an entire continuum of solutions. Our technique relies on the continuum property (connectedness and compactness of the solutions funnel (Kneser's Theorem, combined with the corresponding vector field.

  11. Dynamic Carrying Capacity Analysis of Double-Row Four-Point Contact Ball Slewing Bearing

    OpenAIRE

    Yunfeng Li; Di Jiang

    2015-01-01

    Carrying capacity is the most important performance index for slewing bearings. Maximizing the carrying capacity of slewing bearing is one pursuing goal for the bearing designer; this is usually realized by optimizing the design parameters. A method of analyzing the carrying capacity of double-row four-point contact ball slewing bearing by using dynamic carrying capacity surfaces was proposed in this paper. Based on the dynamic load carrying capacity surface of the slewing bearing, the effect...

  12. Revenue Management Performance Drivers: An Empirical Analysis at Four Points by Sheraton

    OpenAIRE

    Shroff, Avinash

    2009-01-01

    The purpose of this management project is to analyse the current and future scenario of the revenue streams of the Four Points hotel Mumbai in India. Revenue Management (RM) is an important tool for matching supply and demand by segmenting customers into different segments based on their willingness-to-pay and allocating scarce capacity to the different segments in a way that maximizes firm revenues. The benefits of RM are well accepted in the hospitality industry, and the technical aspects o...

  13. Four-point correlation functions in the AdS/CFT correspondence.

    Energy Technology Data Exchange (ETDEWEB)

    Chalmers, G.; Schalm, K.

    1999-02-09

    We examine correlation functions within the correspondence between gauged supergravity on anti-de Sitter space and N = 4 super Yang-Mills theory in Minkowski space. The imaginary parts of four-point functions in momentum space are computed, in addition to particular examples of three-point functions. Exchange diagrams for gravitons are included. The results indicate additional structure in N = 4 super Yang-Mills theory at strong 't Hooft coupling and in the large N limit.

  14. Manifest Ultraviolet Behavior in the Three-Loop Four-Point Amplitude of N=8 Supergravity

    Energy Technology Data Exchange (ETDEWEB)

    Bern, Z.; Carrasco, J.J.M.; /UCLA; Dixon, L.J.; /SLAC; Johansson, H.; /UCLA; Roiban, R.; /Penn State U.

    2008-09-03

    Using the method of maximal cuts, we obtain a form of the three-loop four-point scattering amplitude of N = 8 supergravity in which all ultraviolet cancellations are made manifest. The Feynman loop integrals that appear have a graphical representation with only cubic vertices, and numerator factors that are quadratic in the loop momenta, rather than quartic as in the previous form. This quadratic behavior reflects cancellations beyond those required for finiteness, and matches the quadratic behavior of the three-loop four-point scattering amplitude in N = 4 super-Yang-Mills theory. By direct integration we confirm that no additional cancellations remain in the N = 8 supergravity amplitude, thus demonstrating that the critical dimension in which the first ultraviolet divergence occurs at three loops is D{sub c} = 6. We also give the values of the three-loop divergences in D = 7, 9, 11. In addition, we present the explicitly color-dressed three-loop four-point amplitude of N = 4 super-Yang-Mills theory.

  15. Design and construction of a micro-focus in-line phase-contrast cone-beam CT (PC-CBCT) system for soft tissue imaging

    Science.gov (United States)

    Cai, Weixing; Ning, Ruola

    2010-04-01

    In recent years, the in-line phase-contrast (in-line PC) technique has been implemented using synchrotrons and microfocus x-ray tubes for soft tissue imaging as the in-line PC's image quality enhancement. In this study, a new in-line phase-contrast cone-beam CT (PC-CBCT) system has been designed and tested in our lab to produce higher image quality enhancement. The PC-CBCT system consists of a micro-focus x-ray tube, a high-resolution detector and a rotating phantom holder. The nominal focal spot size is 9 microns, which is expected to produce partially coherent x-rays. The detector system has a phosphor screen, an optical fiber coupling unit and a CMOS chip with an effective pixel pitch of 22.5 microns. Some key system parameters, including tube voltage (or x-ray spectrum), source-to-object distance and object-to-detector distance were balanced and optimized to achieve enough spatial coherence and degree of interference to acquire edge-enhanced phase-contrast images as projection images. The phantom holder was rotated for 360 degrees with a step of 1.2 degrees, and during the rotation in-line PC images were acquired at all angular positions. The FDK algorithm was applied to compute the reconstruction using the edge-enhanced PC images. Small soft tissue samples (breast tissues and animal organs) were scanned and reconstructed. The tomographic images showed enhanced structure edges and details.

  16. In-line micro-matrix solid-phase dispersion extraction for simultaneous separation and extraction of Sudan dyes in different spices.

    Science.gov (United States)

    Rajabi, Maryam; Sabzalian, Sedigheh; Barfi, Behruz; Arghavani-Beydokhti, Somayeh; Asghari, Alireza

    2015-12-18

    A novel, simple, fast, and miniaturized method, termed in-line micro-matrix solid-phase dispersion (in-line MMSPD), coupled with high performance liquid chromatography (HPLC) was developed for the simultaneous extraction and determination of Sudan dyes (i.e. Sudan I-IV, Sudan orange G, Sudan black B, and Sudan red G) with the aid of an experimental design strategy. In this method, a matrix solid-phase dispersion (MSPD) column including a suitable mixture of polar sorbents was inserted in the mobile phase pathway, and while the interfering compounds were retained, the analytes were eluted and entered into the analytical column. In this way, the extraction, elution, and separation of the analytes were performed sequentially. Under the optimal experimental conditions (including the amount of sample, 0.0426g; amount of dispersant phase, 0.0216g of florisil, 0.0227g of silica, 0.0141g of alumina; and blending time, 112s), the limits of detection (LODs), limits of quantification, linear dynamic ranges, and recoveries were obtained to be 0.3-15.3μgkg(-1), 1-50μgkg(-1), 50-28,000μgkg(-1), and 94.5-99.1%, respectively. The results obtained showed that determination of the selected Sudan dyes in food samples using an enough sensitive and a simple analytically validated method like in-line MMSPD may offer a suitable screening method, which could be useful for food analysis and adulteration.

  17. Is Abdominal Muscle Activity Different from Lumbar Muscle Activity during Four-Point Kneeling?

    Directory of Open Access Journals (Sweden)

    Soraya Pirouzi

    2013-12-01

    Full Text Available Background: Stabilization exercises can improve the performance of trunk and back muscles, which are effective in the prevention and treatment of low back pain. The four-point kneeling exercise is one of the most common types of stabilization exercises. This quasi-experimental study aimed to evaluate and compare the level of activation between abdominal and lumbar muscles in the different stages of the four-point kneeling exercise. Methods: The present study was conducted on 30 healthy women between 20 and 30 years old. Muscle activity was recorded bilaterally from transversus abdominis, internal oblique, and multifidus muscles with an electromyography (EMG device during the different stages of the four-point kneeling exercise. All the collected EMG data were normalized to the percentage of maximum voluntary isometric contraction. The repeated measures ANOVA and paired t-test were used for the statistical analysis of the data. Results: A comparison between mean muscle activation in right arm extension and left leg extension showed that left internal oblique and left transverse abdominis muscles produced greater activation during left leg extension (P<0.05. The comparison of mean muscle activation between right arm extension and the bird-dog position showed that, except for the right internal oblique, all the muscles produced higher activation in the bird-dog stage (P<0.05. In comparison to the bird-dog stage, the left multifidus showed high activation during left leg extension (P<0.05. Conclusion: The results of this study showed that the activity of all the above-mentioned muscles during quadruped exercise can provide stability, coordination, and smoothness of movements.

  18. An all order identity between ABJM and N=4 SYM four-point amplitudes

    CERN Document Server

    Bianchi, Marco S; Penati, Silvia

    2011-01-01

    We derive an exact algebraic identity between the two-loop four-point amplitude in ABJM theory and the corresponding one-loop amplitude in N=4 SYM theory. This identity generalizes previous partial results to an exact relation valid at all orders in the IR regulator. Moreover, it allows to conjecture an exact iterative expression for the complete three dimensional amplitude in terms of the BDS ansatz for the four dimensional one, indicating that the strict relation between the two amplitudes experimented at two loops might propagate to all orders. In particular, an almost complete expression for the ABJM amplitude at four loops is derived.

  19. Automatized channel for resistivity measurements in layered materials by four-point probe technique

    Science.gov (United States)

    Gryaznov, A. O.; Savchenko, S. S.; Vokhmintsev, A. S.; Weinstein, I. A.

    2016-09-01

    An automatized channel for measuring the resistivity in materials by the four-point probe technique was developed. The installation was based on Cascade Microtech MPS150 microprobe station, National Instruments PXIe-4143 power supply unit and PXI-4072 digital multimeter. Registration modes of surface and bulk specific resistance for samples with positioning the probes in a line or at square vertices were implemented. Measurements under corresponding modes were carried out for metallic, semiconducting bulk samples and thin coatings. Conductive and optical properties of 10, 20 and 30 nm Au layers formed on quartz glass by magnetron sputtering were investigated.

  20. Primordial non-Gaussianity in noncanonical warm inflation: Three- and four-point correlations

    Science.gov (United States)

    Zhang, Xiao-Min; Ma, Hong-Yang; Chu, Peng-Cheng; Zhu, Jian-Yang

    2017-08-01

    Non-Gaussianity generated in inflation can be contributed by two parts. The first part, denoted by fNL δ N, is the contribution from the four-point correlation of the inflaton field which can be calculated using δ N formalism, and the second part, denoted by fNL int , is the contribution from the three-point correlation function of the inflaton field. We consider the two contributions to the non-Gaussianity in noncanonical warm inflation throughout (noncanonical warm inflation is a new inflationary model which is proposed in X. M. Zhang and J. Y. Zhu, Phys. Rev. D 90, 123519 (2014), 10.1103/PhysRevD.90.123519). We find the two contributions are complementary to each other. The four-point correlation contribution to the non-Gaussianity is overwhelmed by the three-point one in the strong noncanonical limit, while the conclusion is the opposite in the canonical case. We also discuss the influence of the field redefinition, thermal dissipative effect and noncanonical effect to the non-Gaussianity in noncanonical warm inflation.

  1. Beyond van der Pauw: Novel methods for four-point magnetotransport characterization

    Science.gov (United States)

    Zhou, Wang

    In this thesis, the conventional four-point measurement technique and the van der Pauw (vdP) method are systematically investigated in the presence of non-ideal conditions, namely, non-uniform carrier density distribution and absence of ohmic contacts, which are nonetheless commonly encountered in semiconductor characterizations. Upon understanding the challenges in the conventional methods, novel characterization techniques are developed to address these challenges. A longitudinal magnetoresistance asymmetry method was developed to study the carrier density non-uniformity in two-dimensional samples. By analyzing the asymmetric longitudinal magnetoresistance under positive and negative B-fields, an analytical model based on a linear density gradient across the sample was deduced to quantitatively describe the asymmetry. Based on the theoretical model, a practical method was described which enabled one to experimentally measure the density gradient within a single sample. The method requires only measurements of longitudinal resistances R xx and Ryy under both positive and negative B-fields, and equations have been provided to extract both the angle and the magnitude of density gradients from the measured resistances. The method was demonstrated in a GaAs quantum well wafer at cryogenic temperatures and n-GaAs bulk-doped wafer at room temperature. In both systems, the density gradient vectors extracted with our method matched well with the interpolated density gradient vectors estimated from actual density distribution maps as a base comparison set, suggesting that our method can be a universal extension of the vdP method to extract density gradients in various systems. The method also allows one to uncover the true local longitudinal resistivity rhoxx at the center of the sample, which the conventional vdP method cannot describe in the presence of non-uniform densities. The ability to find rhoxx makes it possible to study interesting physics in semiconductors such

  2. Nonlocal Four-Point Boundary Value Problem for the Singularly Perturbed Semilinear Differential Equations

    Directory of Open Access Journals (Sweden)

    Vrabel Robert

    2011-01-01

    Full Text Available Abstract This paper deals with the existence and asymptotic behavior of the solutions to the singularly perturbed second-order nonlinear differential equations. For example, feedback control problems, such as the steady states of the thermostats, where the controllers add or remove heat, depending upon the temperature detected by the sensors in other places, can be interpreted with a second-order ordinary differential equation subject to a nonlocal four-point boundary condition. Singular perturbation problems arise in the heat transfer problems with large Peclet numbers. We show that the solutions of mathematical model, in general, start with fast transient which is the so-called boundary layer phenomenon, and after decay of this transient they remain close to the solution of reduced problem with an arising new fast transient at the end of considered interval. Our analysis relies on the method of lower and upper solutions.

  3. Ultra-shallow junction (USJ) sheet resistance measurements with a non-penetrating four point probe

    Science.gov (United States)

    Benjamin, M. C.; Hillard, R. J.; Borland, J. O.

    2005-08-01

    An accurate method to measure the four point probe (4PP) sheet resistance (RS) of ultra shallow junction (USJ) Source-Drain Extension structures is described. The method utilizes Elastic Material probes (EM-probes) to form non-penetrating contacts to the silicon surface [R.J. Hillard, P.Y. Hung, William Chism, C. Win Ye, W.H. Howland, L.C. Tan, C.E. Kalnas, Characterization and Metrology for ULSI Technology, AIP Conference proceedings 683 (2003) 802.]. The probe design is kinematic and the force is controlled to ensure elastic deformation of the probe material. The probe material is such that large direct tunneling currents can flow through the native oxide thereby forming a low impedance contact. Sheet resistance measurements on USJ implanted P+/N structures with Secondary Ion Mass Spectroscopy (SIMS) junction depths less than 15 nm have been measured. The method is demonstrated on implanted USJ structures and found to be consistent with expectations.

  4. Dynamics of graphite fiber intercalation: In situ resistivity measurements with a four point probe

    Science.gov (United States)

    Jaworske, D. A.

    1984-01-01

    The dynamics of ferric chloride intercalation of single graphite fibers were studied, in situ, using a four point dc bridge. Measurements before, during and after the intercalation showed that the intercalation occurred within minutes at 200 C. Changes in fiber resistivity after exposure to air suggested hydration of the graphite intercalation compound. Deintercalation of the ferric chloride was initiated at temperatures in excess of 400 C. cycling the intercalant into and out of the graphite fiber gave no improvements in fiber resistivity. The activation energy of the ferric chloride intercalation reaction was found to be 17 + or - 4 kcal/mol 1 consistent with the concept of a preliminary nucleation step in the intercalation reaction.

  5. Spatially heterogeneous dynamics investigated via a time-dependent four-point density correlation function

    DEFF Research Database (Denmark)

    Lacevic, N.; Starr, F. W.; Schrøder, Thomas

    2003-01-01

    two-point time-dependent density correlation functions, while providing information about the transient "caging" of particles on cooling, are unable to provide sufficiently detailed information about correlated motion and dynamical heterogeneity. Here, we study a four-point, time-dependent density...... simulations of a binary Lennard-Jones mixture approaching the mode coupling temperature from above. We find that the correlations between particles measured by g4(r,t) and S4(q,t) become increasingly pronounced on cooling. The corresponding dynamical correlation length xi4(t) extracted from the small......-q behavior of S4(q,t) provides an estimate of the range of correlated particle motion. We find that xi4(t) has a maximum as a function of time t, and that the value of the maximum of xi4(t) increases steadily from less than one particle diameter to a value exceeding nine particle diameters in the temperature...

  6. Four-point Bend Testing of Irradiated Monolithic U-10Mo Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Rabin, B. H. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Lloyd, W. R. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Schulthess, J. L. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Wright, J. K. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Lind, R. P. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Scott, L. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Wachs, K. M. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-03-01

    This paper presents results of recently completed studies aimed at characterizing the mechanical properties of irradiated U-10Mo fuel in support of monolithic base fuel qualification. Mechanical properties were evaluated in four-point bending. Specimens were taken from fuel plates irradiated in the RERTR-12 and AFIP-6 Mk. II irradiation campaigns, and tests were conducted in the Hot Fuel Examination Facility (HFEF) at Idaho National Laboratory (INL). The monolithic fuel plates consist of a U-10Mo fuel meat covered with a Zr diffusion barrier layer fabricated by co-rolling, clad in 6061 Al using a hot isostatic press (HIP) bonding process. Specimens exhibited nominal (fresh) fuel meat thickness ranging from 0.25 mm to 0.64 mm, and fuel plate average burnup ranged from approximately 0.4 x 1021 fissions/cm3 to 6.0 x 1021 fissions/cm3. After sectioning the fuel plates, the 6061 Al cladding was removed by dissolution in concentrated NaOH. Pre- and post-dissolution dimensional inspections were conducted on test specimens to facilitate accurate analysis of bend test results. Four-point bend testing was conducted on the HFEF Remote Load Frame at a crosshead speed of 0.1 mm/min using custom-designed test fixtures and calibrated load cells. All specimens exhibited substantially linear elastic behavior and failed in a brittle manner. The influence of burnup on the observed slope of the stress-strain curve and the calculated fracture strength is discussed.

  7. Electrically continuous graphene from single crystal copper verified by terahertz conductance spectroscopy and micro four-point probe

    DEFF Research Database (Denmark)

    Buron, Jonas Christian Due; Pizzocchero, Filippo; Jessen, Bjarke Sørensen

    2014-01-01

    The electrical performance of graphene synthesized by chemical vapor deposition and transferred to insulating surfaces may be compromised by extended defects, including for instance grain boundaries, cracks, wrinkles, and tears. In this study, we experimentally investigate and compare the nano...

  8. Flexible SiO2 cantilevers for torsional self-aligning micro scale four-point probes

    DEFF Research Database (Denmark)

    Kjær, Daniel; Gammelgaard, Lauge; Bøggild, Peter;

    2007-01-01

    to compensate for misalignment is improved at a cost of reduced spring constant. Analytical calculations, numerical simulations on cantilever deflection and comparison with experimental results indicate that a reasonable compromise between torsional flexibility and overall spring constant can be achieved...... by proper dimensioning and placement of the hinge. Furthermore, it is shown that polymeric macro scale cantilever models can provide a fast and reliable understanding of the mechanical deflection properties of microfabricated SiO2 cantilevers....

  9. Cluster magnetic field observations in the magnetosheath: four-point measurements of mirror structures

    Directory of Open Access Journals (Sweden)

    E. A. Lucek

    Full Text Available The Cluster spacecraft have returned the first simultaneous four-point measurements of the magnetosheath. We present an analysis of data recorded on 10 November 2000, when the four spacecrafts observed an interval of strong mirrorlike activity. Correlation analysis between spacecraft pairs is used to examine the scale size of the mirror structures in three dimensions. Two examples are presented which suggest that the scale size of mirror structures is ~ 1500–3000 km along the flow direction, and shortest along the magnetopause normal (< 600 km, which, in this case, is approximately perpendicular to both the mean magnetic field and the magnetosheath flow vector. Variations on scales of ~ 750–1000 km are found along the maximum variance direction. The level of correlation in this direction, however, and the time lag observed, are found to be variable. These first results suggest that variations occur on scales of the order of the spacecraft separation ( ~ 1000 km in at least two directions, but analysis of further examples and a statistical survey of structures observed with different magnetic field orientations and tetrahedral configurations will enable us to describe more fully the size and orientation of mirror structures.

    Key words. Magnetosphenic physics (magnetosheath; plasma waves and instabilities

  10. The Complete Four-Loop Four-Point Amplitude in N

    Energy Technology Data Exchange (ETDEWEB)

    Bern, Z.; Carrasco, J.J.M.; /UCLA; Dixon, Lance J.; /SLAC /CERN; Johansson, H.; /Saclay, SPhT; Roiban, R.; /Penn State U.

    2010-08-25

    We present the complete four-loop four-point amplitude in N = 4 super-Yang-Mills theory, for a general gauge group and general D-dimensional covariant kinematics, and including all non-planar contributions. We use the method of maximal cuts - an efficient application of the unitarity method - to construct the result in terms of 50 four-loop integrals. We give graphical rules, valid in D-dimensions, for obtaining various non-planar contributions from previously-determined terms. We examine the ultraviolet behavior of the amplitude near D = 11/2. The non-planar terms are as well-behaved in the ultraviolet as the planar terms. However, in the color decomposition of the three- and four-loop amplitude for an SU(N{sub c}) gauge group, the coefficients of the double-trace terms are better behaved in the ultraviolet than are the single-trace terms. The results from this paper were an important step toward obtaining the corresponding amplitude in N = 8 supergravity, which confirmed the existence of cancellations beyond those needed for ultraviolet finiteness at four loops in four dimensions. Evaluation of the loop integrals near D = 4 would permit tests of recent conjectures and results concerning the infrared behavior of four-dimensional massless gauge theory.

  11. Comparison of Visual and Acoustic Emission Observations in a Four Point Bending Experiment on Barre Granite

    Science.gov (United States)

    Li, Bing Qiuyi; Einstein, Herbert H.

    2017-09-01

    We present an experimental study in which a pre-notched specimen of Barre Granite was subjected to four point bending under crack mouth opening displacement control. The experimental observations consisted of load-displacement measurements, acoustic emissions, and photography on a macroscopic ( cm) as well as microscopic ( μm) scale. These observations were compared and analysed to better understand process zone development and crack propagation. Load-displacement data showed that the load reaches its maximum at crack initiation, and the machine input work is constant while the crack propagates. AE moment magnitudes between Mw = -6 to -10 were observed, and focal mechanisms consisted of both shear and tensile components. During process zone development, AE formed a large cloud of events located near the notch tip and then tended to occur away from the notch tip as the crack propagated. Image analysis at the microscopic scale showed that microcracks formed and coalesced during process zone development; specifically, the microcracks initiated in tension and then propagated as a series of en-echelon cracks. In general, the synthesis of the three observations showed that a wider bulb of activity at lower energy tended to occur during process zone development, while crack propagation tended to be more spatially concentrated and contained higher energy.

  12. Development of four-point bending fatigue test method using continuously hydrogen-charging pipe specimen

    Science.gov (United States)

    Yoshimoto, T.; Matsuo, T.

    2017-05-01

    To evaluate hydrogen embrittlement, the following two types of testing method are available: (i) testing in high-pressure hydrogen gas environment and (ii) testing in ambient air using hydrogen precharged specimen. Testing in high-pressure hydrogen gas environment is technically difficult and expensive because high-pressure gas equipments, such as high-pressure vessel and pipe, have to be installed in the laboratory. On the other hand, in the case of precharging method, outgassing of hydrogen from the specimen occurs during the test. Therefore, hydrogen embrittlement can hardly be evaluated properly, especially, in long-term testing such as high cycle fatigue test at low frequency. In this study, to effectively evaluate the hydrogen embrittlement in fatigue, an experimental method, which was the four-point bending fatigue test system with a mechanism of internal circulation of hydrogen-charging solution in a pipe specimen, was developed. By using this method, the fatigue crack growth properties in the presence of hydrogen were investigated at frequencies of 0.05 Hz and 1 Hz.

  13. Cluster observes the Earth’s magnetopause: coordinated four-point magnetic field measurements

    Directory of Open Access Journals (Sweden)

    M. W. Dunlop

    Full Text Available The four-spacecraft Cluster mission has provided high-time resolution measurements of the magnetic field from closely maintained separation distances (200–600 km. Four-point coverage of the Earth’s magnetopause began on the 9 and 10 November 2000 when all spacecraft first exited the dusk-side magnetosphere at about 19:00 LT, providing extensive coverage of the near flank magnetosheath and magnetopause boundary layer on re-entry to the magnetosphere. The traversals on this occasion were caused by the arrival of an intense CME at the Earth, which produced a large compression of the magnetopause and high magnetic activity. The magnetopause traversals represent an unprecedented data set, allowing detailed analysis of the local magnetic structure (gradients and dynamics of the magnetopause boundary. By performing minimum variance analysis (MVA on the magnetic field data from all four spacecraft, we demonstrate that the magnetopause was planar on the scale of the spacecraft separation scales and that the transverse scale size of the magnetopause boundary layer was 1000–1100 km. We also show that the motion of the boundary (defined by the magnetic shear at the current layer, is changing over the sequence of spacecraft crossings so that acceleration of the magnetopause can be very high in this region of the magnetosphere. Indeed, the magnetopause speed reaches the order of 300 km/s in response to the arrival of the interplanetary shock. Using MVA coordinates, we have identified a number of magnetospheric and magnetosheath FTE signatures, which are sampled simultaneously by all spacecraft at different distances from and on either side of the magnetopause. The signatures show a variation of scale with distance from the boundary.

    Key words. Magnetospheric physics (magnetopause, cusp and boundary layers Space plasma physics (discontinuities; magnetic reconnection

  14. A Systems Engineering Analysis of Three-Point and Four-Point Wind Turbine Drivetrain Configurations

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Yi; Parsons, Tyler; Dykes, Katherine; King, Ryan N.

    2017-03-01

    This study compares the impact of drivetrain configuration on the mass and capital cost of a series of wind turbines ranging from 1.5 MW to 5.0 MW power ratings for both land-based and offshore applications. The analysis is performed with a new physics-based drivetrain analysis and sizing tool, Drive Systems Engineering (DriveSE), which is part of the Wind-Plant Integrated System Design & Engineering Model. DriveSE uses physics-based relationships to size all major drivetrain components according to given rotor loads simulated based on International Electrotechnical Commission design load cases. The model's sensitivity to input loads that contain a high degree of variability was analyzed. Aeroelastic simulations are used to calculate the rotor forces and moments imposed on the drivetrain for each turbine design. DriveSE is then used to size all of the major drivetrain components for each turbine for both three-point and four-point configurations. The simulation results quantify the trade-offs in mass and component costs for the different configurations. On average, a 16.7% decrease in total nacelle mass can be achieved when using a three-point drivetrain configuration, resulting in a 3.5% reduction in turbine capital cost. This analysis is driven by extreme loads and does not consider fatigue. Thus, the effects of configuration choices on reliability and serviceability are not captured. However, a first order estimate of the sizing, dimensioning and costing of major drivetrain components are made which can be used in larger system studies which consider trade-offs between subsystems such as the rotor, drivetrain and tower.

  15. Modification of the in vivo four-point loading model for studying mechanically induced bone adaptation.

    Science.gov (United States)

    Forwood, M R; Bennett, M B; Blowers, A R; Nadorfi, R L

    1998-09-01

    We modified the noninvasive, in vivo technique for strain application in the tibiae of rats (Turner et al., Bone 12:73-79, 1991). The original model applies four-point bending to right tibiae via an open-loop, stepper-motor-driven spring linkage. Depending on the magnitude of applied load, the model produces new bone formation at periosteal (Ps) or endocortical surfaces (Ec.S). Due to the spring linkage, however, the range of frequencies at which loads can be applied is limited. The modified system replaces this design with an electromagnetic vibrator. A load transducer in series with the loading points allows calibration, the loaders' position to be adjusted, and cyclic loading completed under load control as a closed servo-loop. Two experiments were conducted to validate the modified system: (1) a strain gauge was applied to the lateral surface of the right tibia of 5 adult female rats and strains measured at applied loads from 10 to 60 N; and (2) the bone formation response was determined in 28 adult female Sprague-Dawley rats. Loading was applied as a haversine wave with a frequency of 2 Hz for 18 sec, every second day for 10 days. Peak bending loads were applied at 33, 40, 52, and 64 N, and a sham-loading group was included at 64 N. Strains in the tibiae were linear between 10 and 60 N, and the average peak strain at the Ps.S at 60 N was 2664 +/- 250 microstrain, consistent with the results of Turner's group. Lamellar bone formation was stimulated at the Ec.S by applied bending, but not by sham loading. Bending strains above a loading threshold of 40 N increased Ec lamellar bone formation rate, bone forming surface, and mineral apposition rate with a dose response similar to that reported by Turner et al. (J Bone Miner Res 9:87-97, 1994). We conclude that the modified loading system offers precision for applied loads of between 0 and 70 N, versatility in the selection of loading rates up to 20 Hz, and a reproducible bone formation response in the rat tibia

  16. A test of bosonization at the level of four-point functions in Chern-Simons vector models

    CERN Document Server

    Bedhotiya, Akshay

    2015-01-01

    We study four-point functions in Chern-Simons vector models in the large $N$ limit. We compute the four-point function of the scalar primary to all orders in the `t Hooft coupling $\\lambda=N/k$ in $U(N)_k$ Chern-Simons theory coupled to a fundamental fermion, in both the critical and non-critical theory, for a particular case of the external momenta. These theories cover the entire 3-parameter "quasi-boson" and 2-parameter "quasi-fermion" families of 3-dimensional quantum field theories with a slightly-broken higher spin symmetry. Our results are consistent with the celebrated bosonization duality, as we explicitly verify by calculating four-point functions in the free critical and non-critical bosonic theories.

  17. Thermal conductivity measurements of single-crystalline bismuth nanowires by the four-point-probe 3-ω technique at low temperatures.

    Science.gov (United States)

    Lee, Seung-Yong; Kim, Gil-Sung; Lee, Mi-Ri; Lim, Hyuneui; Kim, Wan-Doo; Lee, Sang-Kwon

    2013-05-10

    We have successfully investigated the thermal conductivity (κ) of single-crystalline bismuth nanowires (BiNWs) with [110] growth direction, via a straightforward and powerful four-point-probe 3-ω technique in the temperature range 10-280 K. The BiNWs, which are well known as the most effective material for thermoelectric (TE) device applications, were synthesized by compressive thermal stress on a SiO2/Si substrate at 250-270 °C for 10 h. To understand the thermal transport mechanism of BiNWs, we present three kinds of experimental technique as follows, (i) a manipulation of a single BiNW by an Omni-probe in a focused ion beam (FIB), (ii) a suspended bridge structure integrating a four-point-probe chip by micro-fabrication to minimize the thermal loss to the substrate, and (iii) a simple 3-ω technique system setup. We found that the thermal transport of BiNWs is highly affected by boundary scattering of both phonons and electrons as the dominant heat carriers. The thermal conductivity of a single BiNW (d ~ 123 nm) was estimated to be ~2.9 W m(-1) K(-1) at 280 K, implying lower values compared to the thermal conductivity of the bulk (~11 W m(-1) K(-1) at 280 K). It was noted that this reduction in the thermal conductivity of the BiNWs could be due to strongly enhanced phonon-boundary scattering at the surface of the BiNWs. Furthermore, we present temperature-dependent (10-280 K) thermal conductivity of the BiNWs using the 3-ω technique.

  18. Electromyographic activity of trunk and hip muscles during stabilization exercises in four-point kneeling in healthy volunteers

    OpenAIRE

    Stevens, Veerle K.; Vleeming, Andry; Bouche, Katie G.; Mahieu, Nele N; Vanderstraeten, Guy G.; Danneels, Lieven A

    2006-01-01

    Stabilization exercises are intended to optimize function of the muscles that are believed to govern trunk stability. Debate exists whether certain muscles are more important than others in optimally performing these exercises. Thirty healthy volunteers were asked to perform three frequently prescribed stabilization exercises in four-point kneeling. The electromyographic activity of different trunk and hip muscles was evaluated. Average amplitudes obtained during the exercises were normalized...

  19. Relationship between bond-breakage correlations and four-point correlations in heterogeneous glassy dynamics: Configuration changes and vibration modes

    Science.gov (United States)

    Shiba, Hayato; Kawasaki, Takeshi; Onuki, Akira

    2012-10-01

    We investigate the dynamic heterogeneities of glassy particle systems in the theoretical schemes of bond breakage and four-point correlation functions. In the bond-breakage scheme, we introduce the structure factor Sb(q,t) and the susceptibility χb(t) to detect the spatial correlations of configuration changes. Here χb(t) attains a maximum at t=tbmax as a function of time t, where the fraction of the particles with broken bonds φb(t) is about 1/2. In the four-point scheme, treating the structure factor S4(q,t) and the susceptibility χ4(t), we detect superpositions of the heterogeneity of bond breakage and that of thermal low-frequency vibration modes. While the former grows slowly, the latter emerges quickly to exhibit complex space-time behavior. In two dimensions, the vibration modes extending over the system yield significant contributions to the four-point correlations, which depend on the system size logarithmically. A maximum of χ4(t) is attained at t=t4max, where these two contributions become of the same order. As a result, t4max is considerably shorter than tbmax.

  20. 半导体表面电学特性微观四点探针测试技术研究进展%Latest development of electrical characterization of semicondutor surface by microscopic four-point probe technique

    Institute of Scientific and Technical Information of China (English)

    李建昌; 王永; 简晓慧; 巴德纯

    2011-01-01

    四探针法是材料学及半导体行业电学表征的常用方法.随着微电子器件尺度持续减小,新型纳米材料研究不断深入,须将探针间距控制到亚微米及其以下范畴才能获得更高的空间分辨率和表面灵敏度.近年来研究人员借助显微技术开发出两类微观四点探针测试系统,即整体式微观四点探针和独立四点扫描隧道显微镜探针系统,随着现代微加工技术的发展,当前探针间距已缩小到几十纳米范围.本文综述了微观四点探针技术近年来的研究进展,主要包括测试理论、系统结构与探针制备.其中,特别详述了涉及探针制备的方法、技术及所面临问题,并展望了微观四点探针研究的发展方向,并给出了一些具体建议.%Four-point probe characterization is a usual method for studying the electrical properties of solids and thin films. The distance between tip and sample in four-point probe technique has to be reduced to sub-micro scale at least in order to obtain expected surface sensitivity and spatial resolution. Therefore, microscopic four-point probes (M4PPs) need to be combined with some microscopy techniques. Two types of M4PPs have been developed in the past few years, which are monolithic micro-four-point probes and four-point scanning tunneling microscopy probes. In this paper, we review the latest development of M4PPs from aspects of system construction, probe structure and test theories. The approaches of probe preparation are discussed in detail. Probe life and sample surface damage are another two big challenges for the microscopic four-point probe technique. To deal with such problems, flexible cantilevers can be used as the probe by keeping a certain angle to the sample surface.

  1. Novel four-point-probe design and nanorobotic dual endeffector strategy for electrical characterization of as-grown SWCNT bundles

    DEFF Research Database (Denmark)

    Eichhorn, V; Fatikow, S; Sardan Sukas, Özlem

    2010-01-01

    In this paper, a novel nanorobotic strategy for non-destructive and direct electrical characterization of as-grown bundles of single-walled carbon nanotubes (SWCNTs) is presented. For this purpose, test patterns of SWCNT bundles having different diameters are grown on a silicon substrate...... by chemical vapor deposition. A new design of microstructured four-point-probes is proposed and fabricated allowing for direct contacting of vertically aligned bundles of SWCNTs. A nanorobotic setup is upgraded into a dual endeffector system to achieve good electrical contact between four...

  2. Four point function of R-currents in N=4 SYM in the Regge limit at weak coupling

    Energy Technology Data Exchange (ETDEWEB)

    Bartels, J.; Mischler, A.M.; Salvadore, M. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik

    2008-04-15

    We compute, in N = 4 super Yang-Mills, the four point correlation function of R-currents in the Regge limit in the leading logarithmic approximation at weak coupling. Such a correlator is the closest analog to photon-photon scattering within QCD, and there is a well defined procedure to perform the analogous computation at strong coupling via AdS/CFT. The main result of this paper is, on the gauge theory side, the proof of Regge factorization and the explicit computation of the R-current impact factors. (orig.)

  3. Flexural and bond strengths of relined denture polymers assessed by four-point bending tests and Weibull analysis.

    Science.gov (United States)

    Polyzois, Gregory L; Lagouvardos, Panagiotis E; Frangou, Maria J

    2012-06-01

    The aim of this study was to (1) investigate the flexural strengths of three denture resins i.e. heat, photopolymerised and microwaved and how it was affected by relining with auto- and visible light-polymerised hard reliners, (2) investigate the bond strengths between denture resins and hard reliners and (3) interpret the results of both tests by utilising Weibull analysis. Specimens (65 × 10 × 2.5 mm) from denture resins, relined and bonded combinations were tested using a four-point bending test in a universal testing machine and a crosshead speed of 5 mm/min. Ten specimens for each bulk resin and denture resin-reliner combination for a total of 150 were tested. Statistical analysis indicated significant differences between bulk materials (p < 0.001) and between reliners (p < 0.001) for flexural and bond strength tests. was concluded that (1) the four-point flexural strength was different between the denture base materials, (2) flexure strength between bulk and relined or between relined with autopolymerised and photopolymerised bases was different, (3) flexural strength among relined denture bases was different and (4) bond strengths among relined denture bases were different. © 2011 The Gerodontology Society and John Wiley & Sons A/S.

  4. The four-point correlator in multifield inflation, the operator product expansion and the symmetries of de Sitter

    Energy Technology Data Exchange (ETDEWEB)

    Kehagias, A., E-mail: kehagias@central.ntua.gr [Physics Division, National Technical University of Athens, 15780 Zografou Campus, Athens (Greece); Riotto, A. [Department of Theoretical Physics and Center for Astroparticle Physics (CAP), 24 quai E. Ansermet, CH-1211 Geneva 4 (Switzerland)

    2013-03-21

    We study the multifield inflationary models where the cosmological perturbation is sourced by light scalar fields other than the inflaton. We exploit the operator product expansion and partly the symmetries present during the de Sitter epoch to characterize the non-Gaussian four-point correlator in the squeezed limit. We point out that the contribution to it from the intrinsic non-Gaussianity of the light fields at horizon crossing can be larger than the usually studied contribution arising on superhorizon scales and it comes with a different shape. Our findings indicate that particular attention needs to be taken when studying the effects of the primordial NG on real observables, such as the clustering of dark matter halos.

  5. Effect of recovery from muscle strength imbalance in lower limb using four point weight bearing reduction system.

    Science.gov (United States)

    Yu, Chang Ho; Kang, Seung Rok; Jeong, Ho Choon; Kim, Kyung; Kwon, Tae Kyu

    2014-01-01

    This study was performed to assess the improvement of muscle strength imbalance in the lower limbs using a four point weight bearing reduction system with a two-belt treadmill. Participants, each having differences in muscle function of the left and right legs of over 20%, were divided into two groups of ten. The participants were involved in experiments progressing 40 minutes per day, 3 days per week, during a period of 4 weeks. The maximal peak torque and average power were measured for testing joint torque in the hip, knee and ankle. The results showed the improvement of muscle imbalance as assessed by the maximal muscle strength was the most effective in the hip joint, while the improvement of muscular reaction was the most effective in the knee joint. We suggest that the method of weight bearing reduction could be sufficient to reduce muscle imbalance in the lower limbs.

  6. Note: a simple approach to fabricate a microscopic four-point probe for conductivity measurements in ultrahigh vacuum.

    Science.gov (United States)

    Pang, Fei; Liang, Xuejin; Chen, Dongmin

    2013-07-01

    We present a simple method to fabricate microscopic four-point probe (M4PP) with spacing of 70-100 μm for conductivity measurements in ultrahigh vacuum. The probe includes four gold wires with 30 μm diameter and a 0.5 mm thickness sapphire slice as cantilever. One of the dual scanning tunneling microscope (DSTM) is replaced by M4PP. As a result, in situ transport measurement could be performed by M4PP and investigation of surface morphology by STM. Finally, we measure conductivity of 14 monolayer Bi(111) epitaxial film on n type Si which is 1.6 × 10(-3) Ω(-1)∕[larger open square].

  7. Automated Micro Hall Effect measurements

    DEFF Research Database (Denmark)

    Petersen, Dirch Hjorth; Henrichsen, Henrik Hartmann; Lin, Rong

    2014-01-01

    With increasing complexity of processes and variety of materials used for semiconductor devices, stringent control of the electronic properties is becoming ever more relevant. Collinear micro four-point probe (M4PP) based measurement systems have become high-end metrology methods for characteriza......With increasing complexity of processes and variety of materials used for semiconductor devices, stringent control of the electronic properties is becoming ever more relevant. Collinear micro four-point probe (M4PP) based measurement systems have become high-end metrology methods...... for characterization and monitoring of sheet resistance as well as sheet carrier density and mobility via the Micro Hall Effect (MHE) method....

  8. Modeling of delamination in carbon/epoxy composite laminates under four point bending for damage detection and sensor placement optimization

    Science.gov (United States)

    Adu, Stephen Aboagye

    Laminated carbon fiber-reinforced polymer composites (CFRPs) possess very high specific strength and stiffness and this has accounted for their wide use in structural applications, most especially in the aerospace industry, where the trade-off between weight and strength is critical. Even though they possess much larger strength ratio as compared to metals like aluminum and lithium, damage in the metals mentioned is rather localized. However, CFRPs generate complex damage zones at stress concentration, with damage progression in the form of matrix cracking, delamination and fiber fracture or fiber/matrix de-bonding. This thesis is aimed at performing; stiffness degradation analysis on composite coupons, containing embedded delamination using the Four-Point Bend Test. The Lamb wave-based approach as a structural health monitoring (SHM) technique is used for damage detection in the composite coupons. Tests were carried-out on unidirectional composite coupons, obtained from panels manufactured with pre-existing defect in the form of embedded delamination in a laminate of stacking sequence [06/904/0 6]T. Composite coupons were obtained from panels, fabricated using vacuum assisted resin transfer molding (VARTM), a liquid composite molding (LCM) process. The discontinuity in the laminate structure due to the de-bonding of the middle plies caused by the insertion of a 0.3 mm thick wax, in-between the middle four (4) ninety degree (90°) plies, is detected using lamb waves generated by surface mounted piezoelectric (PZT) actuators. From the surface mounted piezoelectric sensors, response for both undamaged (coupon with no defect) and damaged (delaminated coupon) is obtained. A numerical study of the embedded crack propagation in the composite coupon under four-point and three-point bending was carried out using FEM. Model validation was then carried out comparing the numerical results with the experimental. Here, surface-to-surface contact property was used to model the

  9. The Role of Home Bleaching Agent on the Fracture Toughness of Resin Composites Using Four-Point Bending Test

    Directory of Open Access Journals (Sweden)

    Ghazvini Ferooz M

    2014-09-01

    Full Text Available Statement of Problem: Resin composites are a common type of tooth coloured restorative materials. These materials are brittle and their major shortcomings are sensitivity to flaws and defects, low tensile strength, and susceptibility to catastrophic failure.The role of home bleaching agents on the fracture toughness of resin composites using four-point bending test is scanty. Objectives: To compare the fracture toughness (KIc of resin composites on a fourpoint bending test and to assess the effect of distilled water and a home bleaching agent on the resistance of the materials to fracture. Materials and Methods: seventy-two bar-shaped specimens were prepared from three materials: Rok (SDI, Estelite (Tokuyama, and Vit-l-escence (Ultradent and divided into three groups. Two groups were assigned as “control” and conditioned in distilled water at 37oC for 24 hours or 21 days, respectively. The specimens in the third group (treatment were stored in distilled water for 21 days and bleached using Polanight (SDI for 2 hours daily. For each material, a total of 24 disc-shaped specimens were prepared and after each time interval loaded in a four-point bending test using a universal testing machine with a crosshead speed of 0.5 mm/m. The maximum load to specimen failure was recorded and the KIc was calculated. Results: Statistical analysis using two-way ANOVA showed a significant relationship between materials and treatment (P<0.05. Tukey’s test showed that after 24 hours of immersion in distilled water, KIc was not significantly different between materials; Rok revealed the highest value followed by Estelite and Vit-l-escence. The bleaching agent significantly decreased the KIc values of Estelite and Rok while it did not affect that of Vita-l-escence. Immersion in distilled water for all resin composites caused a significant decrease in KIc. Conclusion: The fracture toughness of the resin composites was affected by the bleaching agent and 21day

  10. Four-point high time resolution information on electron densities by the electric field experiments (EFW on Cluster

    Directory of Open Access Journals (Sweden)

    A. Pedersen

    Full Text Available For accurate measurements of electric fields, spherical double probes are electronically controlled to be at a positive potential of approximately 1 V relative to the ambient magnetospheric plasma. The spacecraft will acquire a potential which balances the photoelectrons escaping to the plasma and the electron flux collected from the plasma. The probe-to-plasma potential difference can be measured with a time resolution of a fraction of a second, and provides information on the electron density over a wide range of electron densities from the lobes (~ 0.01 cm-3 to the magnetosheath (>10 cm-3 and the plasmasphere (>100 cm-3. This technique has been perfected and calibrated against other density measurements on GEOS, ISEE-1, CRRES, GEOTAIL and POLAR. The Cluster spacecraft potential measurements opens the way for new approaches, particularly near boundaries and gradients where four-point measurements will provide information never obtained before. Another interesting point is that onboard data storage of this simple parameter can be done for complete orbits and thereby will provide background information for the shorter full data collection periods on Cluster. Preliminary calibrations against other density measurements on Cluster will be reported.

    Key words. Magnetospheric physics (magnetopause, cusp, and boundary layers Space plasma physics (spacecraft sheaths, wakes, charging; instruments and techniques

  11. A self-adjustable four-point probing system using polymeric three dimensional coils and non-toxic liquid metal

    Energy Technology Data Exchange (ETDEWEB)

    Oyunbaatar, Nomin-Erdene; Choi, Young Soo; Lee, Dong-Weon, E-mail: mems@jnu.ac.kr [MEMS and Nanotechnology Laboratory, School of Mechanical Engineering, Chonnam National University, Gwangju 500757 (Korea, Republic of)

    2015-12-15

    This paper describes a self-adjustable four-point probe (S4PP) system with a square configuration. The S4PP system consists of 3D polymer coil springs for the independent operation of each tungsten (W) probe, microfluidic channels filled with a nontoxic liquid metal, and a LabView-based control system. The 3D coil springs made by PMMA are fabricated with a 3D printer and are positioned in a small container filled with the non-toxic liquid metal. This unique configuration allows independent self-adjustment of the probe heights for precise measurements of the electrical properties of both flexible and large-step-height microsamples. The feasibility of the fabricated S4PP system is evaluated by measuring the specific resistance of Cr and Au thin films deposited on silicon wafers. The system is then employed to evaluate the electrical properties of a Au thin film deposited onto a flexible and easily breakable silicon diaphragm (spring constant: ∼3.6 × 10{sup −5} N/m). The resistance of the Cr thin films (thickness: 450 nm) with step heights of 60 and 90 μm is also successfully characterized. These experimental results indicate that the proposed S4PP system can be applied to common metals and semiconductors as well as flexible and large-step-height samples.

  12. A self-adjustable four-point probing system using polymeric three dimensional coils and non-toxic liquid metal.

    Science.gov (United States)

    Oyunbaatar, Nomin-Erdene; Choi, Young Soo; Choi, Yong Soo; Lee, Dong-Weon

    2015-12-01

    This paper describes a self-adjustable four-point probe (S4PP) system with a square configuration. The S4PP system consists of 3D polymer coil springs for the independent operation of each tungsten (W) probe, microfluidic channels filled with a nontoxic liquid metal, and a LabView-based control system. The 3D coil springs made by PMMA are fabricated with a 3D printer and are positioned in a small container filled with the non-toxic liquid metal. This unique configuration allows independent self-adjustment of the probe heights for precise measurements of the electrical properties of both flexible and large-step-height microsamples. The feasibility of the fabricated S4PP system is evaluated by measuring the specific resistance of Cr and Au thin films deposited on silicon wafers. The system is then employed to evaluate the electrical properties of a Au thin film deposited onto a flexible and easily breakable silicon diaphragm (spring constant: ∼3.6 × 10(-5) N/m). The resistance of the Cr thin films (thickness: 450 nm) with step heights of 60 and 90 μm is also successfully characterized. These experimental results indicate that the proposed S4PP system can be applied to common metals and semiconductors as well as flexible and large-step-height samples.

  13. Temperature-dependent thermal conductivities of 1D semiconducting nanowires via four-point-probe 3-ω method.

    Science.gov (United States)

    Lee, Seung-Yong; Lee, Mi-Ri; Park, No-Won; Kim, Gil-Sung; Choi, Heon-Jin; Choi, Tae-Youl; Lee, Sang-Kwon

    2013-12-13

    We report on a systematic study of the thermal transport characteristics of both as-grown zinc oxide and gallium nitride nanowires (NWs) via the four-point-probe 3-ω method in the temperature range 130-300 K. Both as-grown NWs were synthesized by a vapor-liquid-solid growth mechanism, and show clear n-type semiconducting behavior without any defects, which enables both the NWs to be promising candidates for thermoelectric materials. To measure the thermal conductivities of both NWs with lower heat loss and measurement errors, the suspended structures were formed by a combination of an e-beam lithography process and a random dispersion method. The measured thermal conductivities of both NWs are greatly reduced compared to their bulk materials due to the enhanced phonon scattering via the size effect and dopants (impurities). Furthermore, we observed that the Umklapp peaks of both NWs are shifted to a higher temperature than those of their bulk counterparts, indicating that phonon-boundary scattering dominates over other phonon scattering due to the size effect.

  14. Crack initiation at high loading rates applying the four-point bending split Hopkinson pressure bar technique

    Directory of Open Access Journals (Sweden)

    Henschel Sebastian

    2015-01-01

    Full Text Available Dynamic crack initiation with crack-tip loading rates of K̇ ≈ 2.106MPa√ms-1 in a high strength G42CrMoS4 steel was investigated. To this end, a previously developed split Hopkinson pressure bar with four-point bending was utilised. V-notched and pre-cracked Charpy specimens were tested. The detection of dynamic crack initiation was performed by analysing the dynamic force equilibrium between the incident and the transmission bar. Additionally, the signal of a near-field strain gauge and high-speed photography were used to determine the instant of crack initiation. To account for vibrations of the sample, a dynamic analysis of the stress intensity factor was performed. The dynamic and static analyses of the tests produced nearly the same results when a force equilibrium was achieved. Fracture-surface analysis revealed that elongated MnS inclusions strongly affected both the dynamic crack initiation and growth. Blunting of the precrack did not take place when a group of MnS inclusions was located directly at the precrack tip. Due to the direction of the elongated MnS inclusions perpendicular to the direction of crack growth, the crack could be deflected. The comparison with a 42CrMo4 steel without elongated MnS inclusions revealed the detrimental effect in terms of resistance to crack initiation. Taking the loading-rate dependency into consideration, it was shown that there was no pronounced embrittlement due to the high loading rates.

  15. Comparison of selective electromyographic activity of the superficial lumbar multifidus between prone trunk extension and four-point kneeling arm and leg lift exercises

    OpenAIRE

    Kim, Jun-Seok; Kang, Min-Hyeok; Jang, Jun-Hyeok; Oh, Jae-Seop

    2015-01-01

    [Purpose] This study examined the selective electromyographic activity of the lumbar paraspinal muscles in healthy male and female subjects in the prone trunk extension (PTE) and four-point kneeling arm and leg lift (FPKAL) exercises to determine the most beneficial exercise for selective activation of the lumbar multifidus (LM). [Subjects and Methods] Twenty healthy male and female subjects participated in this study. Surface electromyographic data were collected from the left-side lumbar er...

  16. Probes Vacillating and Mapping Technique at Testing Micro-area Sheet Resistance

    OpenAIRE

    Zhihui Zhu; Xinfu Liu; Runli Zhang; Ruqing Zhang; Nan Jiang

    2013-01-01

    This article briefly elaborated the basic concepts of the probe vacillated at testing a large silicon wafer with square four point probe equipment. The importance of the micro-area’s sheet resistance is discussed and the basic principles of four point probe measurement technology are analyzed. Some factors that affect the measurement accuracy are studied, and interference can be avoided while measuring and analyzing the impact on square four point probe measurement by probe vacillate. The cal...

  17. The FACT-Melanoma quality-of-life instrument: comparison of a five-point and four-point response scale using the Rasch measurement model.

    Science.gov (United States)

    Winstanley, Julie B; Saw, Robyn; Boyle, Frances; Thompson, John

    2013-02-01

    The FACT-Melanoma (FACT-M) is one of only two validated quality-of-life instruments designed specifically for use in patients with melanoma. The instrument incorporates FACT-G, followed by a set of questionnaire items that are specific to melanoma; all items are scored on a five-point response scale. The primary aim of this study was to evaluate the five-point response format of the FACT-M for goodness of fit to the Rasch measurement model, and to investigate whether rescoring the instrument using a four-point response format improved the psychometric properties. Two data sets of similar patient sample sizes (n=127 and 123) were used to test the reliability and validity of the generic instrument (FACT-G) to measure quality of life for patients with melanoma. The Additional Concerns and Melanoma Surgery subscales were subjected to a more detailed analysis using a combination of confirmatory factor analysis and Rasch analysis techniques. The Rasch model fit of the FACT-M was improved by the use of a four-point response format, together with the deletion of three items. Principal components analysis suggested that two melanoma-specific subscales existed within the Additional Concerns subscale and each could be reduced to seven items, respectively, with improved goodness of fit to the Rasch model. The FACT-M instrument showed improved fit to the Rasch model specifications when the items adopted a four-point response format. These results point to possible improvements in the content and structure of the FACT-M for use in future melanoma clinical trials. However, further study should be conducted with larger samples, selected by disease and treatment status.

  18. Four-point correlation function of a passive scalar field in rapidly fluctuating turbulence: Numerical analysis of an exact closure equation.

    Science.gov (United States)

    Mizuno, Y; Ohi, K; Sogabe, T; Yamamoto, Y; Kaneda, Y

    2010-09-01

    A numerical analysis is made on the four-point correlation function in a similarity range of a model of two-dimensional passive scalar field ψ advected by a turbulent velocity field with infinitely small correlation time. The model yields an exact closure equation for the four-point correlation Ψ{4} of ψ, which may be casted into the form of an eigenvalue problem in the similarity range. The analysis of the eigenvalue problem gives not only the scale dependence of Ψ{4} , but also the dependence on the configuration of the four points. The numerical analysis gives S4(R)∝R{ζ{4}} in the similarity range in which S2(R)∝R{ζ{2}} , where S_{N} is the structure function defined by S{N}(R)≡⟨[ψ(x+R)-ψ(x)]{N} and ζ{4}≠2ζ{2} . The estimate of ζ_{4} by the numerical analysis of the eigenvalue problem is in good agreement with numerical simulations so far reported. The agreement supports the idea of universality of the exponent ζ{4} in the sense that ζ_{4} is insensitive to conditions of ψ outside the similarity range. The numerical analysis also shows that the correlation C(R,r)≡[ψ(x+R)-ψ(x)]{2}[ψ(x+r)-ψ(x)]{2}> is stronger than that given by the joint-normal approximation, and scales like C(R,r)∝(r/R){χ} for r/R<1 with R and r in the similarity range, where χ is a constant depending on the angle between R and r .

  19. Exponential decay of equal-time four-point correlation functions in the Hubbard model on the copper-oxide lattice

    CERN Document Server

    Kashima, Yohei

    2012-01-01

    For the Hubbard model on the two-dimensional copper-oxide lattice, equal-time four-point correlation functions at positive temperature are proved to decay exponentially in the thermodynamic limit if the magnitude of the on-site interactions is smaller than some power of temperature. This result especially implies that the equal-time correlation functions for singlet Cooper pairs of various symmetries decay exponentially in the distance between the Cooper pairs in high temperatures or in low-temperature weak-coupling regimes. The proof is based on a multi-scale integration over the Matsubara frequency.

  20. A computer program to calculate the resistivity of a thin film deposited on a conductive substrate from four-point probe measurements

    Science.gov (United States)

    Oberle, L. G.; Fralick, G. C.

    1986-01-01

    A series of FORTRAN-77 programs is described which correct for the effect of a conducting substrate when a linear four-point probe is used to measure the resistivity of a thin film. The resistivity of the film is given in terms of the thicknesses of the film and substrate, the known resistivity of the substrate, and the measured delta V/I. A full development is given as well as a complete description of the operation of the programs. The programs themselves can be obtained through COSMIC, and are identified as LEW No. 14381.

  1. Precise determination of full matrix of piezo-optic coefficients with a four-point bending technique: the example of lithium niobate crystals.

    Science.gov (United States)

    Krupych, Oleg; Savaryn, Viktoriya; Vlokh, Rostyslav

    2014-04-01

    A recently proposed technique representing a combination of digital imaging laser interferometry with a classical four-point bending method is applied to a canonical nonlinear optical crystal, LiNbO₃, to precisely determine a full matrix of its piezo-optic coefficients (POCs). The contribution of a secondary piezo-optic effect to the POCs is investigated experimentally and analyzed theoretically. Based on the POCs thus obtained, a full matrix of strain-optic coefficients (SOCs) is calculated and the appropriate errors are estimated. A comparison of our experimental errors for the POCs and SOCs with the known reference data allows us to claim the present technique as the most precise.

  2. 四探针测半导体材料杂质分布%THE MEASUREMENT OF IMPURITY DISTRIBUTION IN SEMICODUCTOR MATERIAL WITH FOUR POINT PROBE METHOD

    Institute of Scientific and Technical Information of China (English)

    高玮; 谢宜臣

    2001-01-01

    设计一个新的近代物理实验题目.利用阳极氧化法对半导体材料逐次去层,采用四探针法测量其每层的电阻率及相应杂质浓度,可得出半导体材料的杂质分布N(x).实验设备简单,测量方便,结果准确.并提供了自制四探针测量仪的方法.%A new topic in modern physics experiment is designed. Semiconductor material is removed layer by layer with anode oxidation method. Resistivity and relevant impurity concentration in every layer is measured with four point probe method. The impurity distribution of semiconductor material N(x)is obtained. The experiment equipment is simple, measurement is convenient, and result is accurate. The method to make four point probe instrument is provided.

  3. Comparison of selective electromyographic activity of the superficial lumbar multifidus between prone trunk extension and four-point kneeling arm and leg lift exercises.

    Science.gov (United States)

    Kim, Jun-Seok; Kang, Min-Hyeok; Jang, Jun-Hyeok; Oh, Jae-Seop

    2015-04-01

    [Purpose] This study examined the selective electromyographic activity of the lumbar paraspinal muscles in healthy male and female subjects in the prone trunk extension (PTE) and four-point kneeling arm and leg lift (FPKAL) exercises to determine the most beneficial exercise for selective activation of the lumbar multifidus (LM). [Subjects and Methods] Twenty healthy male and female subjects participated in this study. Surface electromyographic data were collected from the left-side lumbar erector spinae (LES) and LM muscles during PTE and FPKAL exercises. [Results] The LM/LES ratio related to selective activation of the lumbar paraspinal muscles during the FPKAL exercise was higher than that during PTE. [Conclusion] FPKAL exercise is safe and effective for the selective activation of the LM muscle.

  4. The 100th anniversary of the four-point probe technique: the role of probe geometries in isotropic and anisotropic systems.

    Science.gov (United States)

    Miccoli, I; Edler, F; Pfnür, H; Tegenkamp, C

    2015-06-10

    The electrical conductivity of solid-state matter is a fundamental physical property and can be precisely derived from the resistance measured via the four-point probe technique excluding contributions from parasitic contact resistances. Over time, this method has become an interdisciplinary characterization tool in materials science, semiconductor industries, geology, physics, etc, and is employed for both fundamental and application-driven research. However, the correct derivation of the conductivity is a demanding task which faces several difficulties, e.g. the homogeneity of the sample or the isotropy of the phases. In addition, these sample-specific characteristics are intimately related to technical constraints such as the probe geometry and size of the sample. In particular, the latter is of importance for nanostructures which can now be probed technically on very small length scales. On the occasion of the 100th anniversary of the four-point probe technique, introduced by Frank Wenner, in this review we revisit and discuss various correction factors which are mandatory for an accurate derivation of the resistivity from the measured resistance. Among others, sample thickness, dimensionality, anisotropy, and the relative size and geometry of the sample with respect to the contact assembly are considered. We are also able to derive the correction factors for 2D anisotropic systems on circular finite areas with variable probe spacings. All these aspects are illustrated by state-of-the-art experiments carried out using a four-tip STM/SEM system. We are aware that this review article can only cover some of the most important topics. Regarding further aspects, e.g. technical realizations, the influence of inhomogeneities or different transport regimes, etc, we refer to other review articles in this field.

  5. The 100th anniversary of the four-point probe technique: the role of probe geometries in isotropic and anisotropic systems

    Science.gov (United States)

    Miccoli, I.; Edler, F.; Pfnür, H.; Tegenkamp, C.

    2015-06-01

    The electrical conductivity of solid-state matter is a fundamental physical property and can be precisely derived from the resistance measured via the four-point probe technique excluding contributions from parasitic contact resistances. Over time, this method has become an interdisciplinary characterization tool in materials science, semiconductor industries, geology, physics, etc, and is employed for both fundamental and application-driven research. However, the correct derivation of the conductivity is a demanding task which faces several difficulties, e.g. the homogeneity of the sample or the isotropy of the phases. In addition, these sample-specific characteristics are intimately related to technical constraints such as the probe geometry and size of the sample. In particular, the latter is of importance for nanostructures which can now be probed technically on very small length scales. On the occasion of the 100th anniversary of the four-point probe technique, introduced by Frank Wenner, in this review we revisit and discuss various correction factors which are mandatory for an accurate derivation of the resistivity from the measured resistance. Among others, sample thickness, dimensionality, anisotropy, and the relative size and geometry of the sample with respect to the contact assembly are considered. We are also able to derive the correction factors for 2D anisotropic systems on circular finite areas with variable probe spacings. All these aspects are illustrated by state-of-the-art experiments carried out using a four-tip STM/SEM system. We are aware that this review article can only cover some of the most important topics. Regarding further aspects, e.g. technical realizations, the influence of inhomogeneities or different transport regimes, etc, we refer to other review articles in this field.

  6. Performance monitoring of large-scale autonomously healed concrete beams under four-point bending through multiple non-destructive testing methods

    Science.gov (United States)

    Karaiskos, G.; Tsangouri, E.; Aggelis, D. G.; Van Tittelboom, K.; De Belie, N.; Van Hemelrijck, D.

    2016-05-01

    Concrete is still the leading structural material due to its low production cost and great structural design flexibility. Although it is distinguished by such a high durability and compressive strength, it is vulnerable in a series of ambient and operational degradation factors which all too frequently result in crack formation that can adversely affect its mechanical performance. The autonomous healing system, using encapsulated polyurethane-based, expansive, healing agent embedded in concrete, is triggered by the crack formation and propagation and promises material repair and operational service life extension. As shown in our previous studies, the formed cracks on small-scale concrete beams are sealed and repaired by filling them with the healing agent. In the present study, the crack formation and propagation in autonomously healed, large-scale concrete beams are thoroughly monitored through a combination of non-destructive testing (NDT) methods. The ultrasonic pulse velocity (UPV), using embedded low-cost and aggregate-size piezoelectric transducers, the acoustic emission (AE) and the digital image correlation (DIC) are the NDT methods which are comprehensively used. The integrated ultrasonic, acoustic and optical monitoring system introduces an experimental configuration that detects and locates the four-point bending mode fracture on large-scale concrete beams, detects the healing activation process and evaluates the subsequent concrete repair.

  7. The effect of contact stresses in four-point bend testing of graphite/epoxy and graphite/PMR-15 composite beams

    Science.gov (United States)

    Binienda, Wieslaw K.; Roberts, Gary D.; Papadopoulos, Demetrios S.

    1992-01-01

    The results of in-plane four-point bend experiments on unidirectionally reinforced composite beams are presented for graphite/epoxy (T300/934) and graphite/polyimide (G30-500/PMR-15) composites. The maximum load and the location of cracks formed during failure were measured for testpieces with fibers oriented at various angles to the beam axis. Since most of the beams failed near one or more of the load points, the strength of the beams was evaluated in terms of a proposed model, for the local stress distribution. In this model, an exact solution to the problem of a localized contact force acting on a unidirectionally reinforced half plane is used to describe the local stress field. The stress singularity at the load points is treated in a manner similar to the stress singularity at a crack tip in fracture mechanisms problems. Using this approach, the effect of fiber angle and elastic material properties on the strength of the beam is described in terms of a load intensity factor. For fiber angles less than 45 deg from the beam axis, a single crack is initiated near one of the load points at a critical value of the load intensity factor. The critical load intensity factor decreases with the increasing fiber angle. For larger fiber angles, multiple cracks occur at locations both near and away from the load points, and the load intensity factor at failure increases sharply with increasing fiber angle.

  8. Effect of contact stresses in four-point bend testing of graphite/epoxy and graphite/PMR-15 composite beams

    Science.gov (United States)

    Binienda, W. K.; Roberts, G. D.; Papadopoulos, D. S.

    1992-01-01

    The results of in-plane four-point bend experiments on unidirectionally reinforced composite beams are presented for graphite/epoxy (T300/934) and graphite/polyimide (G30-500/PMR-15) composites. The maximum load and the location of cracks formed during failure were measured for testpieces with fibers oriented at various angles to the beam axis. Since most of the beams failed near one or more of the load points, the strength of the beams was evaluated in terms of a proposed model for the local stress distribution. In this model, an exact solution to the problem of a localized contact force acting on a unidirectionally reinforced half plane is used to describe the local stress field. The stress singularity at the load points is treated in a manner similar to the stress singularity at a crack tip in fracture mechanisms problems. Using this approach, the effect of fiber angle and elastic material properties on the strength of the beam is described in terms of a load intensity factor. For fiber angles less than 45 deg from the beam axis, a single crack is initiated near one of the load points at a critical value of the load intensity factor. The critical load intensity factor decreases with increasing fiber angle. For larger fiber angles, multiple cracks occur at locations both near and away from the load points, and the load intensity factor at failure increases sharply with increasing fiber angle.

  9. Effect of contact stresses in four-point bend testing of graphite/epoxy and graphite/PMR-15 composite beams

    Science.gov (United States)

    Binienda, W. K.; Roberts, G. D.; Papadopoulos, D. S.

    1992-01-01

    The results of in-plane four-point bend experiments on unidirectionally reinforced composite beams are presented for graphite/epoxy (T300/934) and graphite/polyimide (G30-500/PMR-15) composites. The maximum load and the location of cracks formed during failure were measured for testpieces with fibers oriented at various angles to the beam axis. Since most of the beams failed near one or more of the load points, the strength of the beams was evaluated in terms of a proposed model for the local stress distribution. In this model, an exact solution to the problem of a localized contact force acting on a unidirectionally reinforced half plane is used to describe the local stress field. The stress singularity at the load points is treated in a manner similar to the stress singularity at a crack tip in fracture mechanisms problems. Using this approach, the effect of fiber angle and elastic material properties on the strength of the beam is described in terms of a load intensity factor. For fiber angles less than 45 deg from the beam axis, a single crack is initiated near one of the load points at a critical value of the load intensity factor. The critical load intensity factor decreases with increasing fiber angle. For larger fiber angles, multiple cracks occur at locations both near and away from the load points, and the load intensity factor at failure increases sharply with increasing fiber angle.

  10. Probes Vacillating and Mapping Technique at Testing Micro-area Sheet Resistance

    Directory of Open Access Journals (Sweden)

    Zhihui Zhu

    2013-04-01

    Full Text Available This article briefly elaborated the basic concepts of the probe vacillated at testing a large silicon wafer with square four point probe equipment. The importance of the micro-area’s sheet resistance is discussed and the basic principles of four point probe measurement technology are analyzed. Some factors that affect the measurement accuracy are studied, and interference can be avoided while measuring and analyzing the impact on square four point probe measurement by probe vacillate. The calculation formula of the square micro-area probe measurement is deduced when probes vacillated discretionarily. An experiment was made with a small wafer sample and accurate resistivity was gotten. The electrical resistivity is tested for another silicon wafer by a square four point probe equipment. Color Mapping graphics was designed for displaying  the micro-area resistance.

  11. Comparison of three and four point bending evaluation of two adhesive bonding systems for glass-ceramic zirconia bi-layered ceramics.

    Science.gov (United States)

    Gee, C; Weddell, J N; Swain, M V

    2017-09-01

    To quantify the adhesion of two bonding approaches of zirconia to more aesthetic glass-ceramic materials using the Schwickerath (ISO 9693-2:2016) three point bend (3PB) [1] test to determine the fracture initiation strength and strain energy release rate associated with stable crack extension with this test and the Charalamabides et al. (1989) [2] four point bend (4PB) test. Two glass-ceramic materials (VITABLOCS Triluxe forte, Vita Zahnfabrik, Germany and IPS.emax CAD, Ivoclar Vivadent, Liechtenstein) were bonded to sintered zirconia (VITA InCeram YZ). The former was resin bonded using a dual-cure composite resin (Panavia F 2.0, Kuraray Medical Inc., Osaka, Japan) following etching and silane conditioning, while the IPS.emax CAD was glass bonded (IPS e.max CAD Crystall/Connect) during crystallization of the IPS.emax CAD. Specimens (30) of the appropriate dimensions were fabricated for the Schwickerath 3PB and 4PB tests. Strength values were determined from crack initiation while strain energy release rate values were determined from the minima in the force-displacement curves with the 3PB test (Schneider and Swain, 2015) [3] and for 4PB test from the plateau region of stable crack extension. Strength values for the resin and glass bonded glass ceramics to zirconia were 22.20±6.72MPa and 27.02±3.49MPa respectively. The strain energy release rates for the two methods used were very similar and for the glass bonding, (4PB) 15.14±5.06N/m (or J/m(2)) and (3PB) 16.83±3.91N/m and resin bonding (4PB) 8.34±1.93N/m and (3PB) 8.44±2.81N/m respectively. The differences in strength and strain energy release rate for the two bonding approaches were statistically significant (pceramics to zirconia. Copyright © 2017 The Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  12. Sentinel lymph node identification in breast cancer using periareolar and subdermal injection of the radiopharmaceutical in four points; Identificacao do linfonodo sentinela no cancer de mama com injecao subdermica periareolar em quatro pontos do radiofarmaco

    Energy Technology Data Exchange (ETDEWEB)

    Coelho-Oliveira, Afranio; Rocha, Augusto Cesar Peixoto [Hospital Universitario Clementino Fraga Filho, Rio de Janeiro, RJ (Brazil). Servico de Ginecologia]. E-mail: afranioliveira@hotmail.com; Gutfilen, Bianca; Pessoa, Maria Carolina Pinheiro; Fonseca, Lea Mirian Barbosa da [Universidade Federal, Rio de Janeiro, RJ (Brazil). Faculdade de Medicina. Dept. de Radiologia e Medicina Nuclear

    2004-08-01

    The aim of this study was to identify the sentinel node by periareolar injection of the radiopharmaceutical in four points, regardless of tumor topography. The sentinel node biopsy reduces morbidity in axillary staging. Fifty-seven sentinel node biopsies were prospectively performed in two groups: group A (25 patients) and group B (32 patients). The peritumoral injection technique was used in group A and the new injection technique in four points was used in group B. The sentinel node biopsies were studied by imprint cytology and hematoxylin and eosin staining followed by axillary lymph node dissection in all patients of group A and only in the positive cases of group B. In group A, 88% (22/25) of the sentinel nodes were identified. There was no false negative case; the sensibility and specificity were of 100%. In group B, 96% (31/32) of sentinel nodes were identified and the status of the axillary lymph nodes showed a predictive positive value of 100%. The number of sentinel nodes varied from 1 to 7, mode of 1 and median of 2.7. The hotspot area was 10 to 100 times the background radiation. The periareolar injection in four points seems to be a good lymphatic mapping method for identification of the sentinel node. We suggest the standardization of this site for injections to identify the sentinel node, although further studies to confirm these findings are necessary. (author)

  13. Micro Engineering

    DEFF Research Database (Denmark)

    Alting, Leo; Kimura, F.; Hansen, Hans Nørgaard

    2003-01-01

    The paper addresses the questions of how micro products are designed and how they are manufactured. Definitions of micro products and micro engineering are discussed and the presentation is aimed at describing typical issues, possibilities and tools regarding design of micro products. The implica......The paper addresses the questions of how micro products are designed and how they are manufactured. Definitions of micro products and micro engineering are discussed and the presentation is aimed at describing typical issues, possibilities and tools regarding design of micro products...

  14. Micro Engineering

    DEFF Research Database (Denmark)

    Alting, Leo; Kimura, F.; Hansen, Hans Nørgaard

    2003-01-01

    The paper addresses the questions of how micro products are designed and how they are manufactured. Definitions of micro products and micro engineering are discussed and the presentation is aimed at describing typical issues, possibilities and tools regarding design of micro products. The implica...

  15. Fiber in-line Michelson Interferometer for refractive index sensing

    Science.gov (United States)

    Liao, C. R.; Wang, D. N.; Wang, Min; Yang, Minghong; Wang, Yiping

    2013-09-01

    A fiber in-line Michelson interferometer based on open micro-cavity is demonstrated, which is fabricated by femtosecond laser micromachining and thin film coating technique. In refractive index sensing, this interferometer operates in a reflection mode of detection, exhibits compact sensor head, good mechanical reliability, wide operation range and high sensitivity of 975nm/RIU (refractive index unit) at the refractive index value of 1.484.

  16. Micro Vision

    OpenAIRE

    Ohba, Kohtaro; OHARA, Kenichi

    2007-01-01

    In the field of the micro vision, there are few researches compared with macro environment. However, applying to the study result for macro computer vision technique, you can measure and observe the micro environment. Moreover, based on the effects of micro environment, it is possible to discovery the new theories and new techniques.

  17. Focused ion beam-assisted manipulation of single and double beta-SiC nanowires and their thermal conductivity measurements by the four-point-probe 3-omega method.

    Science.gov (United States)

    Lee, K M; Choi, T Y; Lee, S K; Poulikakos, D

    2010-03-26

    Control of one-dimensional (1D) nanostructures is demonstrated in this paper by selectively placing and aligning silicon carbide (beta-SiC) nanowires (NWs). We developed a reliable and highly reproducible way of placing a single or double SiC NW on pre-patterned electrodes by using a focused ion beam and a nanomanipulator. 3-omega signals obtained by the four-point-probe method were used in measuring the thermal conductivity of the NWs. The thermal conductivities of the placed single and double beta-SiC NWs were obtained at 82 +/- 6 W mK( - 1) and 73 +/- 5 W mK( - 1), respectively. The proposed technique offers new possibilities for manipulating and evaluating 1D nanoscale materials.

  18. MicroRNA, Angiogenesis and Skeletal Anabolic Response to Mechanical Strain

    Science.gov (United States)

    2012-10-01

    benefits of exercise on bone. 10 week old female C57BL6/J mice were subjected to two weeks of external load by four point bending. During the first week of...redundancy in miR-92 regulation of angiogenesis. 15. SUBJECT TERMS Osteoporosis ,MechanicalLoading,MicroRNA,Anagiogenesis 16. SECURITY CLASSIFICATION OF...benefits of exercise on skeleton. Our second aim in the proposed grant was to test if blocking microRNA regulating angiogenesis increases the benefits of

  19. Methodology for Measurement of Submicron Metallic Wire's Local Electrical Conductivity by Applying Four-points AFM Probe Technique%金属薄膜导线的亚微米局域电导率精确测量技术

    Institute of Scientific and Technical Information of China (English)

    吴蕾; 葛耀峥; 居冰峰

    2011-01-01

    作为薄膜器件最重要物理量之一的局域电导率的定量测定,能在保证性能、提高成品率、完善制作工艺等方面起关键作用.利用基于原子力显微镜(Atomic force microscope,AFM)的4电极微探针局域电导率测量技术,精确测量厚度为350nm、宽度分别为50.0 μm、25.0μm、5.0 μm、2.0μm及600 nm、纯度为99.999%的铝薄膜导线的电导率.由于被测试件宽度和厚度方向的尺寸明显缩小且十分接近电极的最小间距,综合考虑电极尺寸、不同批次电极的加工精度和加工参数、4个电极间的位置误差等几个影响测量精度的因素,修正电导率的计算模型并将传统4电极电导率测量法的应用领域拓展到亚微米级微观尺度.试验结果证明基于AFM的4电极微探针技术在亚微米级局域电导率测量方面的能力.%The quantitative measurement of electrical conductivity plays a key role in ensuring material performance, improving yield and fabrication process. The four-points AFM probe technique is applied for the purpose of quantitatively measuring local conductivities of the 99.999% aluminum wires and 350 nm thickness and different widths of 600 mn, 2.0 μm, 5.0 μm, 25.0 βm and 50.0 βm. As position the width and thickness of the specimen is very close to the minimum distance of the electrodes, we consider the factors that affect the measurement accuracy, such as size, diversity of parameter and precision in processing and position error of the four-points AFM probe, modify the calculation model of conductivity and extend the traditional four-electrode conductivity measurements to the sub-micron level. The repeatability of conductivity measurements indicates that this four-point AFM probe technique could be used for fast in situ characterization of local electrical properties of nanocircuits and nanodevices.

  20. Four-point bending JCOC process:A new technology for forming longitudinally submerged arc welding pipe%大型直缝焊管四点弯曲JCOC成形新工艺

    Institute of Scientific and Technical Information of China (English)

    赵军; 孙红磊; 宋晓抗; 马瑞

    2012-01-01

    在分析大型直缝焊管四点弯曲JCO成形力学原理的基础上,对缩径矫圆的理论和实验进行研究,提出了四点弯曲JCOC成形新工艺.该工艺具有成形道次少、生产效率高、无需预弯边、残余应力小、柔性程度高、成形质量好和防止缺陷扩大等成形特点和优势.按照相似性原理,采用JCOC成形新工艺,以X80钢级φ1219mm×22mm钢管为原型,同比例缩小模具和管件尺寸,制成缩径矫圆后φ260.4mm× 4.7mm管坯.该批管坯的椭圆度最大值≤0.5%,满足生产技术要求.JCOC成形新工艺具有良好的市场推广和工程应用价值.%Based on the analysis of the mechanical principles of the "four-point bending JCO (J-Forming C-Forming O-Forming)" process for LSAW (longitudinal submerged ard welding) pipe as well as theoretical and experimental researches on "compression to make round", this paper presented a new technology called the "four-point bending JCOC (J-Forming C-Forming O-Forming and Compression to make round) process". The advantages of the new technology included fewer steps of formation, higher pro-ductivity, the dispensing with crimping process, less residual stress, higher flexibility, better forming quality and preventing the expansion of flaws. Scaling down the mold and pipe dimensions in accordance with the principle of similarity, this experiment used the new technology to make φ260. 4mm× 4. 7mm pipe samples from φ1219mm× 22mm of X80 steel pipe. The samples made by the new process met production requirements with the ovality up to 0. 5%. This indicated that the new technology had good marketing and engineering applications.

  1. Micro Manufacturing

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard

    2003-01-01

    . If a micro manufacturing system isn’t designed rationally and correctly, it will be high-cost, unreliable, and not robust. For micro products and systems it is a continuously increasing challenge to create the operational basis for an industrial production. As the products through product development...... processes are made applicable to a large number of customers, the pressure in regard to developing production technologies that make it possible to produce the products at a reasonable price and in large numbers is growing. The micro/nano manufacturing programme at the Department of Manufacturing...

  2. Growing bubbles rising in line

    Directory of Open Access Journals (Sweden)

    John F. Harper

    2001-01-01

    Full Text Available Over many years the author and others have given theories for bubbles rising in line in a liquid. Theory has usually suggested that the bubbles will tend towards a stable distance apart, but experiments have often showed them pairing off and sometimes coalescing. However, existing theory seems not to deal adequately with the case of bubbles growing as they rise, which they do if the liquid is boiling, or is a supersaturated solution of a gas, or simply because the pressure decreases with height. That omission is now addressed, for spherical bubbles rising at high Reynolds numbers. As the flow is then nearly irrotational, Lagrange's equations can be used with Rayleigh's dissipation function. The theory also works for bubbles shrinking as they rise because they dissolve.

  3. Micro Manufacturing

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard

    2003-01-01

    Manufacturing deals with systems that include products, processes, materials and production systems. These systems have functional requirements, constraints, design parameters and process variables. They must be decomposed in a systematic manner to achieve the best possible system performance....... If a micro manufacturing system isn’t designed rationally and correctly, it will be high-cost, unreliable, and not robust. For micro products and systems it is a continuously increasing challenge to create the operational basis for an industrial production. As the products through product development...... processes are made applicable to a large number of customers, the pressure in regard to developing production technologies that make it possible to produce the products at a reasonable price and in large numbers is growing. The micro/nano manufacturing programme at the Department of Manufacturing...

  4. Micro Marketing

    Institute of Scientific and Technical Information of China (English)

    Yu Yan

    2012-01-01

    In November the Chinese movie industry experienced a startling surprise.Love Is Not Blind,a low-budget movie with no prominent director or major star,hit 344.8million yuan ($54.5 million) in box office revenue,despite the film's budget was only 9 million yuan ($1.4 million).The film,which tells the 33-day experience of a girl named Huang Xiaoxian after she breaks up with her boyfriend,owes its unexpected blockbusting success to its innovative marketing strategy:micro-blog marketing.The number of followers of the official micro-blog for Love Is Not Blind hit nearly 100,000,attracted by rccommendations of related micro-blog messages,impressive box office lines,and positive word of mouth.By December 7,search queries for Love Is Not Blind had exceeded 8 million.Those for Wang Xiaojian,the lcading male,were close to 1.5 million.

  5. Construção de uma fonte de corrente e de uma sonda para medida de condutividade pelo método da sonda de quatro pontas The construction of an eletrical currente source and of a probe for conductivity measurement by a four point probe method

    Directory of Open Access Journals (Sweden)

    Olacir Alves Araújo

    2003-10-01

    Full Text Available This paper describes the construction of an eletrical current source and of a probe to be used in the measurement of eletrical conductivity through a four-point probe method. These pieces of equipments can be obtained at the low price of US$ 50.00 and are adequate for eletrical conductivity measurements in the semiconductor range, that is from 10-1 to 10-6 S cm-1.

  6. Micro club

    CERN Multimedia

    Micro club

    2014-01-01

    Opération NEMO   Pour finir en beauté les activités spéciales que le CMC a réalisé pendant cette année 2014, pour commémorer le 60ème anniversaire du CERN, et le 30ème du Micro Club, l’ Opération NEMO aura cette année un caractère très particulier. Nous allons proposer 6 fabricants de premier ordre qui offriront chacun deux ou trois produits à des prix exceptionnels. L’opération débute le lundi 17 novembre 2014. Elle se poursuivra  jusqu’au samedi 6 décembre inclus. Les délais de livraison seront de deux à trois semaines, selon les fabricants. Donc les commandes faites la dernière semaine, du 1 au 6 décembre, risquent d’arriver qu'au début du mois de janvier 2015. Liste de fabricants part...

  7. Micro club

    CERN Multimedia

    Micro Club

    2014-01-01

    Jeudi 18 septembre 2014 à 18h30 au Bât. 567 R-029 Le CERN MICRO CLUB organise un Atelier sur la sécurité informatique. La Cyber-sécurité : Ce qui se passe vraiment, comment ne pas en être victime ! Orateur : Sebastian Lopienski Adjoint au Computer Security Officer du Département IT. Sujet : Cet exposé vous présentera les modes de sécurité actuels et les problèmes touchants les applications logicielles des ordinateurs, les réseaux ainsi que leurs utilisateurs. Cela inclus des informations sur les nouveaux types de vulnérabilité, les vecteurs d'attaque récents et une vue d'ensemble sur le monde de la cyber-sécurité en 2014. Biographie : Sebastian Lopienski travaille au CERN depuis 2001. Il est actuellement adjoint au Computer Security Officer et s'occupe de la protection de...

  8. Quality control of injection moulded micro mechanical parts

    DEFF Research Database (Denmark)

    Gasparin, Stefania; Tosello, Guido; Hansen, Hans Nørgaard

    2009-01-01

    Quality control of micro components is an increasing challenge. Smaller mechanical parts are characterized by smaller tolerance to be verified. This paper focuses on the dimensional verification of micro injection moulded components selected from an industrial application. These parts are measured...... using an Optical Coordinate Measuring Machine (OCMM), which guarantees fast surface scans suitable for in line quality control. The uncertainty assessment of the measurements is calculated following the substitution method. To investigate the influence parameters in optical coordinate metrology two...

  9. and minimum plastic zone radius (MPZR) for four point bend ...

    African Journals Online (AJOL)

    user

    LEFM) approach. ... where the radius of plastic zone takes either a local or global minimum depending on the ..... facilities provided by the Research Centre, B V B College of Engineering & ... American institute of physics conference proceedings.

  10. Two- and four-point Kapitza resistance between harmonic solids

    NARCIS (Netherlands)

    Maassen van den Brink, A.; Dekker, H.

    1996-01-01

    The calculation of the Kapitza boundary resistance between dissimilar harmonic solids has since long (Little [Can. J. Phys. 37 (1959) 334]) suffered from a paradox: this resistance erroneously tends to a finite value in the limit of identical solids. We resolve this paradox by calculating temperatur

  11. 7 CFR 993.504 - In-line inspection.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false In-line inspection. 993.504 Section 993.504 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... CALIFORNIA Pack Specification as to Size Definitions § 993.504 In-line inspection. In-line inspection means...

  12. 7 CFR 993.106 - In-line inspection.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false In-line inspection. 993.106 Section 993.106 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... CALIFORNIA Administrative Rules and Regulations Definitions § 993.106 In-line inspection. In-line inspection...

  13. Micro-propulsion and micro-combustion; Micropropulsion microcombustion

    Energy Technology Data Exchange (ETDEWEB)

    Ribaud, Y.; Dessornes, O.

    2002-10-01

    The AAAF (french space and aeronautic association) organized at Paris a presentation on the micro-propulsion. The first part was devoted to the thermal micro-machines for micro drones, the second part to the micro-combustion applied to micro-turbines. (A.L.B.)

  14. Micro-Organ Device

    Science.gov (United States)

    Gonda, Steve R. (Inventor); Chang, Robert C. (Inventor); Starly, Binil (Inventor); Culbertson, Christopher (Inventor); Holtorf, Heidi L. (Inventor); Sun, Wei (Inventor); Leslie, Julia (Inventor)

    2013-01-01

    A method for fabricating a micro-organ device comprises providing a microscale support having one or more microfluidic channels and one or more micro-chambers for housing a micro-organ and printing a micro-organ on the microscale support using a cell suspension in a syringe controlled by a computer-aided tissue engineering system, wherein the cell suspension comprises cells suspended in a solution containing a material that functions as a three-dimensional scaffold. The printing is performed with the computer-aided tissue engineering system according to a particular pattern. The micro-organ device comprises at least one micro-chamber each housing a micro-organ; and at least one microfluidic channel connected to the micro-chamber, wherein the micro-organ comprises cells arranged in a configuration that includes microscale spacing between portions of the cells to facilitate diffusion exchange between the cells and a medium supplied from the at least one microfluidic channel.

  15. In-line phase shift tomosynthesis

    Energy Technology Data Exchange (ETDEWEB)

    Hammonds, Jeffrey C.; Price, Ronald R.; Pickens, David R.; Donnelly, Edwin F. [Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232 (United States)

    2013-08-15

    Purpose: The purpose of this work is to (1) demonstrate laboratory measurements of phase shift images derived from in-line phase-contrast radiographs using the attenuation-partition based algorithm (APBA) of Yan et al.[Opt. Express 18(15), 16074–16089 (2010)], (2) verify that the APBA reconstructed images obey the linearity principle, and (3) reconstruct tomosynthesis phase shift images from a collection of angularly sampled planar phase shift images.Methods: An unmodified, commercially available cabinet x-ray system (Faxitron LX-60) was used in this experiment. This system contains a tungsten anode x-ray tube with a nominal focal spot size of 10 μm. The digital detector uses CsI/CMOS with a pixel size of 50 × 50 μm. The phantoms used consisted of one acrylic plate, two polystyrene plates, and a habanero pepper. Tomosynthesis images were reconstructed from 51 images acquired over a ±25° arc. All phase shift images were reconstructed using the APBA.Results: Image contrast derived from the planar phase shift image of an acrylic plate of uniform thickness exceeded the contrast of the traditional attenuation image by an approximate factor of two. Comparison of the planar phase shift images from a single, uniform thickness polystyrene plate with two polystyrene plates demonstrated an approximate linearity of the estimated phase shift with plate thickness (−1600 rad vs −2970 rad). Tomographic phase shift images of the habanero pepper exhibited acceptable spatial resolution and contrast comparable to the corresponding attenuation image.Conclusions: This work demonstrated the feasibility of laboratory-based phase shift tomosynthesis and suggests that phase shift imaging could potentially provide a new imaging biomarker. Further investigation will be needed to determine if phase shift contrast will be able to provide new tissue contrast information or improved clinical performance.

  16. Identificação do linfonodo sentinela no câncer de mama com injeção subdérmica periareolar em quatro pontos do radiofármaco Sentinel lymph node identification in breast cancer using periareolar and subdermal injection of the radiopharmaceutical in four points

    Directory of Open Access Journals (Sweden)

    Afrânio Coelho-Oliveira

    2004-08-01

    Full Text Available Este estudo visa identificar o linfonodo sentinela por meio da injeção exclusiva de radiofármaco periareolar subdérmico em quatro pontos, independente da topografia do tumor. A biópsia do linfonodo sentinela diminui a morbidade no estadiamento da axila. Foram realizadas 57 biópsias do linfonodo sentinela, em pacientes com câncer de mama, prospectivamente, em dois grupos: grupo A (25 pacientes e grupo B (32 pacientes. Realizamos a injeção do radiofármaco peritumoral no grupo A, e nova técnica periareolar em quatro pontos no grupo B. A biópsia do linfonodo sentinela foi estudada por "imprint" citológico e hematoxilina e eosina, seguida de linfadenectomia axilar no grupo A e nos casos positivos do grupo B. No grupo A foram identificados 88% (22/25 de linfonodos sentinelas, não houve falso-negativo, com sensibilidade e especificidade de 100%; no grupo B foram identificados 96% (31/32 de linfonodos sentinelas e valor preditivo positivo de 100%. O número de linfonodos sentinelas variou de 1 a 7, moda de 1 e média de 2,7, a área de maior captação variou de 10 a 100 vezes. A injeção periareolar em quatro pontos se apresenta como bom método no mapeamento linfático para identificação do linfonodo sentinela. A padronização deste sítio pode ser o de escolha para identificação do linfonodo sentinela, sendo necessário maior número de casos para confirmação destes achados.The aim of this study was to identify the sentinel node by periareolar injection of the radiopharmaceutical in four points, regardless of tumor topography. The sentinel node biopsy reduces morbidity in axillary staging. Fifty-seven sentinel node biopsies were prospectively performed in two groups: group A (25 patients and group B (32 patients. The peritumoral injection technique was used in group A and the new injection technique in four points was used in group B. The sentinel node biopsies were studied by imprint cytology and hematoxilin and eosin staining

  17. Search for Bs0 --> micro+ micro- and B0 --> micro+ micro- decays with 2 fb-1 of pp collisions.

    Science.gov (United States)

    Aaltonen, T; Adelman, J; Akimoto, T; Albrow, M G; Alvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Beauchemin, P-H; Bedeschi, F; Bednar, P; Behari, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; Dagenhart, D; Datta, M; Davies, T; de Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; De Lorenzo, G; Dell'orso, M; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Forrester, S; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; Garcia, J E; Garfinkel, A F; Genser, K; Gerberich, H; Gerdes, D; Giagu, S; Giakoumopolou, V; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C M; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B-Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Hays, C; Heck, M; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; Iyutin, B; James, E; Jayatilaka, B; Jeans, D; Jeon, E J; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Kar, D; Karchin, P E; Kato, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Koay, S A; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kraus, J; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, S E; Kuhr, T; Kulkarni, N P; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Lecompte, T; Lee, J; Lee, J; Lee, Y J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Lovas, L; Lu, R-S; Lucchesi, D; Lueck, J; Luci, C; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; Macqueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maki, T; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis, A; Margaroli, F; Marino, C; Marino, C P; Martin, A; Martin, M; Martin, V; Martínez, M; Martínez-Ballarín, R; Maruyama, T; Mastrandrea, P; Masubuchi, T; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moed, S; Moggi, N; Moon, C S; Moore, R; Morello, M; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Mumford, R; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Oldeman, R; Orava, R; Osterberg, K; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Reisert, B; Rekovic, V; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Safonov, A; Sakumoto, W K; Salamanna, G; Saltó, O; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyria, A; Shalhout, S Z; Shapiro, M D; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakyan, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sun, H; Suslov, I; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Thom, J; Thompson, A S; Thompson, G A; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tu, Y; Turini, N; Ukegawa, F; Uozumi, S; Vallecorsa, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Vellidis, C; Veszpremi, V; Vidal, M; Vidal, R; Vila, I; Vilar, R; Vine, T; Vogel, M; Volobouev, I; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner-Kuhr, J; Wagner, W; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zheng, Y; Zucchelli, S

    2008-03-14

    We have performed a search for B(s)(0) --> micro(+) micro(-) and B(0) --> micro(+) micro(-) decays in pp collisions at square root s = 1.96 TeV using 2 fb(-1) of integrated luminosity collected by the CDF II detector at the Fermilab Tevatron Collider. The observed number of B(s)(0) and B0 candidates is consistent with background expectations. The resulting upper limits on the branching fractions are B(B(s)0) --> micro(+) micro(-)) micro(+) micro(-))<1.8 x 10(-8) at 95% C.L.

  18. Applications of dimensional micro metrology to the product and process quality control in manufacturing of precision polymer micro components

    DEFF Research Database (Denmark)

    Tosello, Guido; Hansen, Hans Nørgaard; Gasparin, Stefania

    2009-01-01

    Precision manufacturing of micro injection moulded (mu IM) components presents challenges in terms of quality control due to the miniaturization of product dimensions and tolerances. This paper addresses product compliance with specifications, focusing on tolerances of dimensions and position on mu...... IM components selected from industrial production. Two systems were analysed: a tactile coordinate measuring machine (CMM) with sub-micrometer uncertainty and an optical CMM allowing fast measurements suitable for in-line quality control. Product quality control capability, measuring uncertainty...... and calibration guidelines are discussed for both systems. Finally, a new approach for the manufacturing of hybrid micro polymer-metal calibrated objects is proposed....

  19. MicroRNAs

    DEFF Research Database (Denmark)

    Devaux, Yvan; Stammet, Pascal; Friberg, Hans

    2015-01-01

    cardiac arrest would allow subsequent health care delivery to be tailored to individual patients. However, currently available predictive methods and biomarkers lack sufficient accuracy and therefore cannot be generally recommended in clinical practice. MicroRNAs have recently emerged as potential...... biomarkers of cardiovascular diseases. While the biomarker value of microRNAs for myocardial infarction or heart failure has been extensively studied, less attention has been devoted to their prognostic value after cardiac arrest. This review highlights the recent discoveries suggesting that microRNAs may...

  20. microRNA

    OpenAIRE

    Xin, Xiong; Ning, Zhou

    2007-01-01

    MicroRNAs (miRNAs) are short, 20-22 nucleotide RNA molecules that function as negative regulators of gene expression in eukaryotic organisms. RNA mediated gene silencing pathways have essential roles in development, cell differentiation, proliferation, and cell death. It is becoming clear that microRNAs can play a very important role in regulation of gene expression. Understanding the basic mechanism of miRNA biogenesis is one of the central aims of molecular biologists in the future. MicroRN...

  1. Fabrication and Analysis of Micro Contact Based Probe Cell for IC Testing

    Directory of Open Access Journals (Sweden)

    M. Idzdihar Idris

    2015-06-01

    Full Text Available This study presents the fabrication process and analysis of micro contact probe cell for IC testing deposited by dc sputtering technique on a glass substrate. It is designed to solve and replace pogo pins in IC testing process. In previous study, the new model of test socket with new materials in different shapes were designed by using ANSYS as Finite Element Analysis (FEA software and the best parameter were obtained. According to the optimized parameters, prototype structures of the micro-contacts are fabricated using DC Sputtering with materials like copper and tungsten on base copper on glass substrates. Micro contact with thickness of 2800-7000 nm were successively deposited on glass substrate at sputtering power of 125 W in argon ambient gas with pressure of 10-15multiply 10-3 Torr at a room temperature. The structural and electrical properties of micro contact were investigated by using profilometer, Scanning Electron Microscopy (SEM, Atomic Force Microscopy (AFM and four point probes. Results show that the film thickness increased as the deposition the time getting longer. The Root Mean Square (RMS roughnesses obtained are all in a good quality. On the other hand, the resistivity of micro contacts was less than 4 u&Omega-cm, which has good conductive properties. Consequently, this design is appropriate for replacing the conventional pogo pin based testing tools.

  2. In-line rheological characterisation of wastewater sludges using non ...

    African Journals Online (AJOL)

    2015-10-05

    Oct 5, 2015 ... capabilities of the in-line ultrasound technique for different viscosities and fluid properties. ... Tube viscometry offers the possibility of in-line rheological ..... curvature at shear rates lower than 200 s-1 indicates that the sludges ...

  3. Micro metal forming

    CERN Document Server

    2013-01-01

    Micro Metal Forming, i. e. forming of parts and features with dimensions below 1 mm, is a young area of research in the wide field of metal forming technologies, expanding the limits for applying metal forming towards micro technology. The essential challenges arise from the reduced geometrical size and the increased lot size. In order to enable potential users to apply micro metal forming in production, information about the following topics are given: tribological behavior: friction between tool and work piece as well as tool wear mechanical behavior: strength and formability of the work piece material, durability of the work pieces size effects: basic description of effects occurring due to the fact, that the quantitative relation between different features changes with decreasing size process windows and limits for forming processes tool making methods numerical modeling of processes and process chains quality assurance and metrology All topics are discussed with respect to the questions relevant to micro...

  4. Micro-surgical endodontics.

    Science.gov (United States)

    Eliyas, S; Vere, J; Ali, Z; Harris, I

    2014-02-01

    Non-surgical endodontic retreatment is the treatment of choice for endodontically treated teeth with recurrent or residual disease in the majority of cases. In some cases, surgical endodontic treatment is indicated. Successful micro-surgical endodontic treatment depends on the accuracy of diagnosis, appropriate case selection, the quality of the surgical skills, and the application of the most appropriate haemostatic agents and biomaterials. This article describes the armamentarium and technical procedures involved in performing micro-surgical endodontics to a high standard.

  5. Micro Calorimeter for Batteries

    Energy Technology Data Exchange (ETDEWEB)

    Santhanagopalan, Shriram [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-08-01

    As battery technology forges ahead and consumer demand for safer, more affordable, high-performance batteries grows, the National Renewable Energy Laboratory (NREL) has added a patented Micro Calorimeter to its existing family of R&D 100 Award-winning Isothermal Battery Calorimeters (IBCs). The Micro Calorimeter examines the thermal signature of battery chemistries early on in the design cycle using popular coin cell and small pouch cell designs, which are simple to fabricate and study.

  6. Behavioral Analysis of E-commerce Acceptance in Micro-enterprises

    Institute of Scientific and Technical Information of China (English)

    XU Lei; WANG Jian-qiong

    2013-01-01

    E-commerce present opportunities and challenges for businesses, especially for micro-enterprises. This paper proposed a theoretical framework that in line with the unique characteristics of E-commerce acceptance in micro-enterprises in Chengdu, which is based on the unified theory of acceptance and use of technology (UTAUT) model. The extending UTAUT model includes key constructs of performance expectation, perceived behavioral control and the characteristics of owner-managers.

  7. Micro-Discharge Micro-Thruster

    Science.gov (United States)

    2005-06-01

    breakdown at the maximum applied voltage (900 V) in Argon. The back side of the Paschen curve for Ar occurs at a pressure-length (P·d) product of less than...significant capacitance to ground from either lead (~ 100 nF). As small as this is, it had a profound effect on the discharge (see next section). A more space... effect in most thrusters even in the 100 Watt class. For a micro-discharge, even a stray coupling capacitance 50 pF observed for the power leads

  8. Sustainable Micro-Manufacturing of Micro-Components via Micro Electrical Discharge Machining

    OpenAIRE

    Valeria Marrocco; Giacomo Copani; Irene Fassi; Francesco Modica

    2011-01-01

    Micro-manufacturing emerged in the last years as a new engineering area with the potential of increasing peoples’ quality of life through the production of innovative micro-devices to be used, for example, in the biomedical, micro-electronics or telecommunication sectors. The possibility to decrease the energy consumption makes the micro-manufacturing extremely appealing in terms of environmental protection. However, despite this common belief that the micro-scale implies a higher sustainabil...

  9. Micro-robotics; La microrobotique

    Energy Technology Data Exchange (ETDEWEB)

    Bourjault, A.; Chaillet, N.

    2002-07-01

    The aim of micro-robotics is to study, design, realize and control micro-robots. The underlying scientifical problems concern the miniaturization, the design and control of these micro-robots which requires a strongly pluri-disciplinary approach. In the micro-world, the classical laws of physics cannot be applied in the same way as in the macro-world: forces usually negligible, like the adhesion, electrostatic, Van der Waals forces etc.. have a considerable effect and influence at these scales and are not easily taken into consideration in models. Thus such models of micro-robots are difficult to build and are in general incomplete. The dynamical behaviour of all the components is strongly non-linear and requires adapted control laws. Thus the experimental approach is of prime importance in order to completely reanalyze the main functions of the robot: locomotion, gripping, manipulation. The scientifical problem comprises several aspects and refers to several scientific communities. Among these aspects, this book has retained the essential ones: the miniaturization, the design and the control. Content: 1 - the problems of micro-robotics; 2 - the state-of-the-art; 3 - micro-technologies; 4 - micro-actuators; 5 - micro-actuators in shape memory alloys for micro-robotics; 6 - piezoelectric micro-actuators; 7 - micro-gripping and micro-manipulation; 8 - distributed micro-robots based on silicon technology. (J.S.)

  10. Micro scanning probes

    CERN Document Server

    Niblock, T

    2001-01-01

    This thesis covers the design methodology, theory, modelling, fabrication and evaluation of a Micro-Scanning-Probe. The device is a thermally actuated bimorph quadrapod fabricated using Micro Electro Mechanical Systems technology. A quadrapod is a structure with four arms, in this case a planar structure with the four arms forming a cross which is dry etched out of a silicon diaphragm. Each arm has a layer of aluminium deposited on it forming a bimorph. Through heating each arm actuation is achieved in the plane of the quadrapod and the direction normal to it. Fabrication of the device has required the development of bulk micromachining techniques to handle post CMOS fabricated wafers and the patterning of thickly sputtered aluminium in bulk micro machined cavities. CMOS fabrication techniques were used to incorporate diodes onto the quadrapod arms for temperature measurement of the arms. Fine tungsten and silicon tips have also been fabricated to allow tunnelling between the tip and the platform at the centr...

  11. Monolithic MACS micro resonators

    Science.gov (United States)

    Lehmann-Horn, J. A.; Jacquinot, J.-F.; Ginefri, J. C.; Bonhomme, C.; Sakellariou, D.

    2016-10-01

    Magic Angle Coil Spinning (MACS) aids improving the intrinsically low NMR sensitivity of heterogeneous microscopic samples. We report on the design and testing of a new type of monolithic 2D MACS resonators to overcome known limitations of conventional micro coils. The resonators' conductors were printed on dielectric substrate and tuned without utilizing lumped element capacitors. Self-resonance conditions have been computed by a hybrid FEM-MoM technique. Preliminary results reported here indicate robust mechanical stability, reduced eddy currents heating and negligible susceptibility effects. The gain in B1 /√{ P } is in agreement with the NMR sensitivity enhancement according to the principle of reciprocity. A sensitivity enhancement larger than 3 has been achieved in a monolithic micro resonator inside a standard 4 mm rotor at 500 MHz. These 2D resonators could offer higher performance micro-detection and ease of use of heterogeneous microscopic substances such as biomedical samples, microscopic specimens and thin film materials.

  12. Silicon micro-mold

    Science.gov (United States)

    Morales, Alfredo M.

    2006-10-24

    The present invention describes a method for rapidly fabricating a robust 3-dimensional silicon-mold for use in preparing complex metal micro-components. The process begins by depositing a conductive metal layer onto one surface of a silicon wafer. A thin photoresist and a standard lithographic mask are then used to transfer a trace image pattern onto the opposite surface of the wafer by exposing and developing the resist. The exposed portion of the silicon substrate is anisotropically etched through the wafer thickness down to conductive metal layer to provide an etched pattern consisting of a series of rectilinear channels and recesses in the silicon which serve as the silicon micro-mold. Microcomponents are prepared with this mold by first filling the mold channels and recesses with a metal deposit, typically by electroplating, and then removing the silicon micro-mold by chemical etching.

  13. Micro-machining.

    Science.gov (United States)

    Brinksmeier, Ekkard; Preuss, Werner

    2012-08-28

    Manipulating bulk material at the atomic level is considered to be the domain of physics, chemistry and nanotechnology. However, precision engineering, especially micro-machining, has become a powerful tool for controlling the surface properties and sub-surface integrity of the optical, electronic and mechanical functional parts in a regime where continuum mechanics is left behind and the quantum nature of matter comes into play. The surprising subtlety of micro-machining results from the extraordinary precision of tools, machines and controls expanding into the nanometre range-a hundred times more precise than the wavelength of light. In this paper, we will outline the development of precision engineering, highlight modern achievements of ultra-precision machining and discuss the necessity of a deeper physical understanding of micro-machining.

  14. Tunable micro-optics

    CERN Document Server

    Duppé, Claudia

    2015-01-01

    Presenting state-of-the-art research into the dynamic field of tunable micro-optics, this is the first book to provide a comprehensive survey covering a varied range of topics including novel materials, actuation concepts and new imaging systems in optics. Internationally renowned researchers present a diverse range of chapters on cutting-edge materials, devices and subsystems, including soft matter, artificial muscles, tunable lenses and apertures, photonic crystals, and complete tunable imagers. Special contributions also provide in-depth treatment of micro-optical characterisation, scanners, and the use of natural eye models as inspiration for new concepts in advanced optics. With applications extending from medical diagnosis to fibre telecommunications, Tunable Micro-optics equips readers with a solid understanding of the broader technical context through its interdisciplinary approach to the realisation of new types of optical systems. This is an essential resource for engineers in industry and academia,...

  15. Methods and systems for micro machines

    Science.gov (United States)

    Stalford, Harold L.

    2017-04-11

    A micro machine may be in or less than the micrometer domain. The micro machine may include a micro actuator and a micro shaft coupled to the micro actuator. The micro shaft is operable to be driven by the micro actuator. A tool is coupled to the micro shaft and is operable to perform work in response to at least motion of the micro shaft.

  16. Method of fabricating a micro machine

    Science.gov (United States)

    Stalford, Harold L

    2014-11-11

    A micro machine may be in or less than the micrometer domain. The micro machine may include a micro actuator and a micro shaft coupled to the micro actuator. The micro shaft is operable to be driven by the micro actuator. A tool is coupled to the micro shaft and is operable to perform work in response to at least motion of the micro shaft.

  17. Micro-RNAs

    DEFF Research Database (Denmark)

    Taipaleenmäki, H.; Hokland, L. B.; Chen, Li

    2012-01-01

    Osteoblast differentiation and bone formation (osteogenesis) are regulated by transcriptional and post-transcriptional mechanisms. Recently, a novel class of regulatory factors termed microRNAs has been identified as playing an important role in the regulation of many aspects of osteoblast biology...... including proliferation, differentiation, metabolism and apoptosis. Also, preliminary data from animal disease models suggest that targeting miRNAs in bone can be a novel approach to increase bone mass. This review highlights the current knowledge of microRNA biology and their role in bone formation...

  18. Micro energy harvesting

    CERN Document Server

    Briand, Danick; Roundy, Shad

    2015-01-01

    With its inclusion of the fundamentals, systems and applications, this reference provides readers with the basics of micro energy conversion along with expert knowledge on system electronics and real-life microdevices. The authors address different aspects of energy harvesting at the micro scale with a focus on miniaturized and microfabricated devices. Along the way they provide an overview of the field by compiling knowledge on the design, materials development, device realization and aspects of system integration, covering emerging technologies, as well as applications in power management, e

  19. Lectures in Micro Meteorology

    DEFF Research Database (Denmark)

    Larsen, Søren Ejling

    This report contains the notes from my lectures on Micro scale meteorology at the Geophysics Department of the Niels Bohr Institute of Copenhagen University. In the period 1993-2012, I was responsible for this course at the University. At the start of the course, I decided that the text books...... available in meteorology at that time did not include enough of the special flavor of micro meteorology that characterized the work of the meteorology group at Risø (presently of the Institute of wind energy of the Danish Technical University). This work was focused on Boundary layer flows and turbulence...

  20. MicroCulture

    DEFF Research Database (Denmark)

    Marchetti, Emanuela

    2012-01-01

    This paper proposes a playful learning scenario, to enhance children’s museum experience, and the design of MicroCulture, a new learning platform. MicroCulture has been developed through a participatory design process, involving around 25 children. The perspective proposed in this paper is focused...... on enhancing existing storytelling practices, so to provide a more tangible grounding to the communication of historical processes and to elicit a lively dialogue between children and guides. In this perspective, it is proposed to turn storytelling, as a museum learning practice, into a more dialogic...

  1. Non destructive characterization of cortical bone micro-damage by nonlinear resonant ultrasound spectroscopy.

    Directory of Open Access Journals (Sweden)

    Sylvain Haupert

    Full Text Available The objective of the study was to evaluate the ability of a nonlinear ultrasound technique, the so-called nonlinear resonant ultrasound spectroscopy (NRUS technique, for detecting early microdamage accumulation in cortical bone induced by four-point bending fatigue. Small parallelepiped beam-shaped human cortical bone specimens were subjected to cyclic four-point bending fatigue in several steps. The specimens were prepared to control damage localization during four-point bending fatigue cycling and to unambiguously identify resonant modes for NRUS measurements. NRUS measurements were achieved to follow the evolution of the nonlinear hysteretic elastic behavior during fatigue-induced damage. After each fatigue step, a small number of specimens was removed from the protocol and set apart to quantitatively assess the microcrack number density and length using synchrotron radiation micro-computed tomography (SR-µCT. The results showed a significant effect of damage steps on the nonlinear hysteretic elastic behavior. No significant change in the overall length of microcracks was observed in damaged regions compared to the load-free control regions. Only an increased number of shortest microcracks, those in the lowest quartile, was noticed. This was suggestive of newly formed microcracks during the early phases of damage accumulation. The variation of nonlinear hysteretic elastic behavior was significantly correlated to the variation of the density of short microcracks. Our results suggest that the nonlinear hysteretic elastic behavior is sensitive to early bone microdamage. Therefore NRUS technique can be used to monitor fatigue microdamage progression in in vitro experiments.

  2. Micro-Scale Thermoacoustics

    Science.gov (United States)

    Offner, Avshalom; Ramon, Guy Z.

    2016-11-01

    Thermoacoustic phenomena - conversion of heat to acoustic oscillations - may be harnessed for construction of reliable, practically maintenance-free engines and heat pumps. Specifically, miniaturization of thermoacoustic devices holds great promise for cooling of micro-electronic components. However, as devices size is pushed down to micro-meter scale it is expected that non-negligible slip effects will exist at the solid-fluid interface. Accordingly, new theoretical models for thermoacoustic engines and heat pumps were derived, accounting for a slip boundary condition. These models are essential for the design process of micro-scale thermoacoustic devices that will operate under ultrasonic frequencies. Stability curves for engines - representing the onset of self-sustained oscillations - were calculated with both no-slip and slip boundary conditions, revealing improvement in the performance of engines with slip at the resonance frequency range applicable for micro-scale devices. Maximum achievable temperature differences curves for thermoacoustic heat pumps were calculated, revealing the negative effect of slip on the ability to pump heat up a temperature gradient. The authors acknowledge the support from the Nancy and Stephen Grand Technion Energy Program (GTEP).

  3. Tolerances in micro manufacturing

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Zhang, Yang; Islam, Aminul

    2017-01-01

    This paper describes a method for analysis of tolerances in micro manufacturing. It proposes a mapping oftolerances to dimensions and compares this with current available international standards. The analysisdocuments that tolerances are not scaled down as the absolute dimension. In practice...

  4. Programming the BBC micro

    CERN Document Server

    Ferguson, John D; Macari, Louie; Williams, Peter H

    1983-01-01

    Programming the BBC Micro is a 12-chapter book that begins with a description of the BBC microcomputer, its peripheral, and faults. Subsequent chapters focus on practice in programming, program development, graphics, words, numbers, sound, bits, bytes, and assembly language. The interfacing, file handling, and detailed description of BBC microcomputer are also shown.

  5. Phase separation micro molding

    NARCIS (Netherlands)

    Vogelaar, Laura

    2005-01-01

    The research described in this thesis concerns the development of a new microfabrication method, Phase Separation Micro Molding (PSμM). While microfabrication is still best known from semiconductor industry, where it is used to integrate electrical components on a chip, the scope has immensely expan

  6. Micro Mobility Marketing

    DEFF Research Database (Denmark)

    Hosbond, Jens Henrik; Skov, Mikael B.

    2008-01-01

    and differences between micro mobility marketing and the traditional mobile marketing in the large. Finally, we suggest areas for further study.Journal of Targeting, Measurement and Analysis for Marketing (2007) 16, 68-77. doi:10.1057/palgrave.jt.5750058; published online 24 December 2007...

  7. Micro-hydro power

    Energy Technology Data Exchange (ETDEWEB)

    Fraenkel, P.; Paish, O. (IT Power, Eversley (United Kingdom)); Harvey, A.; Brown, A.; Edwards, R. (Intermediate Technology Development Group Ltd., Rugby (GB)); Bokalders, V. (Stockholm Environment Inst. (SE))

    1991-01-01

    This guide is specifically addressed to the practical needs of development workers. An overview of micro-hydro is given, and preliminary studies are discussed. Hydrology and site surveys are considered and civil works, penstocks, turbines, governing, drive systems, electrical power, basic economics, commissioning and testing, and operation and maintenance are reviewed in detail. (U.K.).

  8. Micro- and Nanoengineering

    NARCIS (Netherlands)

    Schroen, C.G.P.H.

    2015-01-01

    There are two overall themes, micro- and nanotechnology, which are capable of changing the future of food considerably. In microtechnology, production of foods and food ingredients is investigated at small scale; the results are thus that larger scale production is considered through operating many

  9. Micro-PROUST.

    Science.gov (United States)

    Johnson, W. Lewis; Soloway, Elliot

    This detailed description of a microcomputer version of PROUST (Program Understander for Students), a knowledge-based system that finds nonsyntactic bugs in Pascal programs written by novice programmers, presents the inner workings of Micro-PROUST, which was written in Golden LISP for the IBM-PC (512K). The contents include: (1) a reprint of an…

  10. Cold Gas Micro Propulsion

    NARCIS (Netherlands)

    Louwerse, M.C.

    2009-01-01

    This thesis describes the development of a micro propulsion system. The trend of miniaturization of satellites requires small sized propulsion systems. For particular missions it is important to maintain an accurate distance between multiple satellites. Satellites drift apart due to differences in

  11. Irrigation and fertigation with drip and alternative micro irrigation systems in northern highbush blueberry

    Science.gov (United States)

    The effects of nitrogen (N) fertigation using conventional drip and alternative micro irrigation systems were evaluated in six cultivars of northern highbush blueberry. The drip system consisted of two laterals of drip tubing, with 2 L/h in-line emitters (point source) spaced every 0.45 m, on each s...

  12. Sparse Reconstruction for Micro Defect Detection in Acoustic Micro Imaging.

    Science.gov (United States)

    Zhang, Yichun; Shi, Tielin; Su, Lei; Wang, Xiao; Hong, Yuan; Chen, Kepeng; Liao, Guanglan

    2016-10-24

    Acoustic micro imaging has been proven to be sufficiently sensitive for micro defect detection. In this study, we propose a sparse reconstruction method for acoustic micro imaging. A finite element model with a micro defect is developed to emulate the physical scanning. Then we obtain the point spread function, a blur kernel for sparse reconstruction. We reconstruct deblurred images from the oversampled C-scan images based on l₁-norm regularization, which can enhance the signal-to-noise ratio and improve the accuracy of micro defect detection. The method is further verified by experimental data. The results demonstrate that the sparse reconstruction is effective for micro defect detection in acoustic micro imaging.

  13. Micro Embossing of Ceramic Green Substrates for Micro Devices

    CERN Document Server

    Shan, X -C; Maw, H P; Lu, C W; Lam, Y C

    2008-01-01

    Multilayered ceramic substrates with embedded micro patterns are becoming increasingly important, for example, in harsh environment electronics and microfluidic devices. Fabrication of these embedded micro patterns, such as micro channels, cavities and vias, is a challenge. This study focuses on the process of patterning micro features on ceramic green substrates using micro embossing. A ceramic green tape that possessed near-zero shrinkage in the x-y plane was used, six layers of which were laminated as the embossing substrate. The process parameters that impact on the pattern fidelity were investigated and optimized in this study. Micro features with line-width as small as several micrometers were formed on the ceramic green substrates. The dynamic thermo-mechanical analysis indicated that extending the holding time at certain temperature range would harden the green substrates with little effect on improving the embossing fidelity. Ceramic substrates with embossed micro patterns were obtain d after co-firi...

  14. Sparse Reconstruction for Micro Defect Detection in Acoustic Micro Imaging

    Directory of Open Access Journals (Sweden)

    Yichun Zhang

    2016-10-01

    Full Text Available Acoustic micro imaging has been proven to be sufficiently sensitive for micro defect detection. In this study, we propose a sparse reconstruction method for acoustic micro imaging. A finite element model with a micro defect is developed to emulate the physical scanning. Then we obtain the point spread function, a blur kernel for sparse reconstruction. We reconstruct deblurred images from the oversampled C-scan images based on l1-norm regularization, which can enhance the signal-to-noise ratio and improve the accuracy of micro defect detection. The method is further verified by experimental data. The results demonstrate that the sparse reconstruction is effective for micro defect detection in acoustic micro imaging.

  15. In-line hologram segmentation for volumetric samples.

    Science.gov (United States)

    Orzó, László; Göröcs, Zoltán; Fehér, András; Tőkés, Szabolcs

    2013-01-01

    We propose a fast, noniterative method to segment an in-line hologram of a volumetric sample into in-line subholograms according to its constituent objects. In contrast to the phase retrieval or twin image elimination algorithms, we do not aim or require to reconstruct the complex wave field of all the objects, which would be a more complex task, but only provide a good estimate about the contribution of the particular objects to the original hologram quickly. The introduced hologram segmentation algorithm exploits the special inner structure of the in-line holograms and applies only the estimated supports and reconstruction distances of the corresponding objects as parameters. The performance of the proposed method is demonstrated and analyzed experimentally both on synthetic and measured holograms. We discussed how the proposed algorithm can be efficiently applied for object reconstruction and phase retrieval tasks.

  16. Micro Information Systems

    DEFF Research Database (Denmark)

    Ulslev Pedersen, Rasmus; Kühn Pedersen, Mogens

    2014-01-01

    such as medical and manufacturing. These new sensor applications have implications for information systems (IS) and, the authors visualize this new class of information systems as fractals growing from an established class of systems; namely that of information systems (IS). The identified applications...... and implications are used as an empirical basis for creating a model for these small new information systems. Such sensor systems are called embedded systems in the technical sciences, and the authors want to couple it with general IS. They call the merger of these two important research areas (IS and embedded...... systems) for micro information systems (micro-IS). It is intended as a new research field within IS research. An initial framework model is established, which seeks to capture both the possibilities and constraints of this new paradigm, while looking simultaneously at the fundamental IS and ICT aspects...

  17. CERN MicroClub

    CERN Multimedia

    CERN MicroClub

    2016-01-01

    Le CERN Micro Club (en partenariat avec Google Education et EU Code Week) organise un évènement éducatif exceptionnel autour de trois kits scientifiques basés sur le mini-ordinateur Raspberry Pi : Le Bras Robotique "Poppy Ergo Jr", conçu par l'équipe-projet Flowers (Centre de recherche Inria Bordeaux Sud-Ouest, ENSTA Paris Tech). Le kit de détection de rayons cosmiques "Muon Hunter", conçu en partenariat entre Mr Mihaly Vadai et les membres du CERN Micro Club. La voiture radio-commandée programmable Wifi "GianoPi", conçue en partenariat avec le campus "La Chataigneraie", pour l'Ecole Internationale de Genève.   Le vendredi 7 octobre (de 18h à 20h) : Une conférence gratuite et ouverte à tous (limitée à 100 personnes), pendant laquelle v...

  18. Micro pulse laser radar

    Science.gov (United States)

    Spinhirne, James D. (Inventor)

    1993-01-01

    An eye safe, compact, solid state lidar for profiling atmospheric cloud and aerosol scattering is disclosed. The transmitter of the micro pulse lidar is a diode pumped micro-J pulse energy, high repetition rate Nd:YLF laser. Eye safety is obtained through beam expansion. The receiver employs a photon counting solid state Geiger mode avalanche photodiode detector. Data acquisition is by a single card multichannel scaler. Daytime background induced quantum noise is controlled by a narrow receiver field-of-view and a narrow bandwidth temperature controlled interference filter. Dynamic range of the signal is limited to optical geometric signal compression. Signal simulations and initial atmospheric measurements indicate that micropulse lider systems are capable of detecting and profiling all significant cloud and aerosol scattering through the troposphere and into the stratosphere. The intended applications are scientific studies and environmental monitoring which require full time, unattended measurements of the cloud and aerosol height structure.

  19. Understanding Micro Plasmas

    CERN Document Server

    Winter, J; Böke, M; Ellerweg, D; Hemke, T; Knake, N; Mussenbrock, T; Niermann, B; Schröder, D; der Gathen, V Schulz-von; von Keudell, A

    2011-01-01

    Micro plasmas are operated around atmospheric pressure exhibiting pronounced non-equilibrium characteristics, i.e. they possess energetic electrons while ions and neutrals remain cold. They have gained significant interest due to their enormous application potential e.g. in the biomedical, surface modification and light source areas, just to name a few. Many different configurations are in use. Their understanding and quantification is mandatory for further progress in applications. We report on recent progress in the diagnostics and simulation of the entire micro plasma system from gas introduction, via the plasma discharge up to the samples at the example of a plasma jet operated in He/O2 in an ambient air environment.

  20. Scanning micro-sclerometer

    Science.gov (United States)

    Oliver, Warren C.; Blau, Peter J.

    1994-01-01

    A scanning micro-sclerometer measures changes in contact stiffness and correlates these changes to characteristics of a scratch. A known force is applied to a contact junction between two bodies and a technique employing an oscillating force is used to generate the contact stiffness between the two bodies. As the two bodies slide relative to each other, the contact stiffness changes. The change is measured to characterize the scratch.

  1. MicroRNA pharmacogenomics

    DEFF Research Database (Denmark)

    Rukov, Jakob Lewin; Shomron, Noam

    2011-01-01

    polymorphisms, copy number variations or differences in gene expression levels of drug metabolizing or transporting genes and drug targets. In this review paper, we focus instead on microRNAs (miRNAs): small noncoding RNAs, prevalent in metazoans, that negatively regulate gene expression in many cellular...... processes. We discuss how miRNAs, by regulating the expression of pharmacogenomic-related genes, can play a pivotal role in drug efficacy and toxicity and have potential clinical implications for personalized medicine....

  2. Aflatoxin determination using in-line immunoaffinity chromatopgraphy in foods

    NARCIS (Netherlands)

    Jinap, S.; Rijk, de T.C.; Arzandeh, S.; Kleijnen, H.C.H.; Zomer, P.; Weg, van der G.; Mol, J.G.J.

    2012-01-01

    Short throughput times with high precision and sensitivity are of interest of any laboratory. An in-line immunoaffinity chromatographic cleanup procedure coupled to High Performance Liquid Chromatography (HPLC) and fluorescence detection was developed for the purpose of quantification of the

  3. Aflatoxin determination using in-line immunoaffinity chromatopgraphy in foods

    NARCIS (Netherlands)

    Jinap, S.; Rijk, de T.C.; Arzandeh, S.; Kleijnen, H.C.H.; Zomer, P.; Weg, van der G.; Mol, J.G.J.

    2012-01-01

    Short throughput times with high precision and sensitivity are of interest of any laboratory. An in-line immunoaffinity chromatographic cleanup procedure coupled to High Performance Liquid Chromatography (HPLC) and fluorescence detection was developed for the purpose of quantification of the aflatox

  4. Single channel in-line multimodal digital holography.

    Science.gov (United States)

    Rivenson, Yair; Katz, Barak; Kelner, Roy; Rosen, Joseph

    2013-11-15

    We present a new single channel in-line setup for holographic recording that can properly record various objects that cannot be recorded by the Gabor holographic method. This configuration allows the recording of holograms based on several modalities while addressing important issues of the original Gabor setup, including the well-known twin-image problem and the weak scattering condition.

  5. Micro-cantilevers for non-destructive characterization of nanograss uniformity

    DEFF Research Database (Denmark)

    Petersen, Dirch Hjorth; Wang, Fei; Olesen, Mikkel Buster

    2011-01-01

    measurements may be useful for process uniformity characterization. The method is applied for characterization of TiW coated nanograss uniformity. Three-way flexible L-shaped cantilever electrodes are used to avoid damage to the fragile surface, and a relative standard deviation on measurement repeatability......We demonstrate an application of three-way flexible micro four-point probes for indirect uniformity characterization of surface morphology. The mean sheet conductance of a quasi-planar 3D nanostructured surface is highly dependent on the surface morphology, and thus accurate sheet conductance...... of 0.12 % is obtained with a measurement yield of 97%. Finally, variations in measured sheet conductance are correlated to the surface morphology as characterized by electron microscopy....

  6. Wear of micro end mills

    DEFF Research Database (Denmark)

    Bissacco, Giuliano; Hansen, Hans Nørgaard; De Chiffre, Leonardo

    2005-01-01

    This paper addresses the important issue of wear on micro end mills considering relevant metrological tools for its characterization and quantification. Investigation of wear on micro end mills is particularly difficult and no data are available in the literature. Small worn volumes cause large...... deviations from the ideal micro tool shape, dramatically changing the cutting edge profile as well as rake and clearance angles. This critically affects the performance of the micro tool leading to increased cutting forces and micro tool deflections with detrimental effects on the accuracy of the machined...... part. For this investigation 200 microns end mills are considered. Visual inspection of the micro tools requires high magnification and depth of focus. 3D reconstruction based on scanning electron microscope (SEM) images and stereo-pair technique is foreseen as a possible method for quantification...

  7. micro strip gas chamber

    CERN Multimedia

    1998-01-01

    About 16 000 Micro Strip Gas Chambers like this one will be used in the CMS tracking detector. They will measure the tracks of charged particles to a hundredth of a millimetre precision in the region near the collision point where the density of particles is very high. Each chamber is filled with a gas mixture of argon and dimethyl ether. Charged particles passing through ionise the gas, knocking out electrons which are collected on the aluminium strips visible under the microscope. Such detectors are being used in radiography. They give higher resolution imaging and reduce the required dose of radiation.

  8. MicroCMOS design

    CERN Document Server

    Song, Bang-Sup

    2011-01-01

    MicroCMOS Design covers key analog design methodologies with an emphasis on analog systems that can be integrated into systems-on-chip (SoCs). Starting at the transistor level, this book introduces basic concepts in the design of system-level complementary metal-oxide semiconductors (CMOS). It uses practical examples to illustrate circuit construction so that readers can develop an intuitive understanding rather than just assimilate the usual conventional analytical knowledge. As SoCs become increasingly complex, analog/radio frequency (RF) system designers have to master both system- and tran

  9. Silica Micro Encapsulation

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, P.; Whitbread-Jordan, M. [KEECO (United Kingdom)

    2001-04-01

    The article explains how Silica Micro Encapsulation (SME) water treatment technology may be transferred from metal mining to coal mining operations. KEECO has been developing a unique solution for treating acid rock drainage in the metal sulphide mining sector and following trials in metal mining operations (described in the article), is preparing to transfer the technology to the coal industry. SME technology comprises metal precipitation and encapsulation accomplished with proprietary chemical, KB-1, and a group of patented chemical dosing systems, the K-series, to dose KB-1 into contaminated liquid wastes as a dry powder. 4 figs., 4 tabs.

  10. Micro manufacturing techniques and applications

    CERN Document Server

    Du, Ruxu; Li, Zifu

    2013-01-01

    Micro/meso-scale manufacturing has been developed in research fields of machining, forming, materials and others, but its potential to industries are yet to be fully realized. The theme of the current volume was to build a bridge joining academic research and industrial needs in micro manufacturing. Among the 12 papers selected for publication are three keynote addresses onmicro and desktop factories for micro/meso-scale manufacturing applicationsand future visions, tissue cutting mechanics and applications for needlecore biopsy and guidance, and micro-texturing onto amorphous carbonmaterials

  11. Micro-pattern gaseous detectors

    CERN Document Server

    Shekhtman, L I

    2002-01-01

    Introduced at the end of 1980s micro-pattern gas detectors perform much better than classic wire chambers. They allow to achieve both excellent localization accuracy and high rate capability that make this technology attractive for charged particle tracking at high luminosity colliders. During its evolution micro-pattern gas technology gave raise to many different types of devices such as micro-strip gas chambers, MicroMEGAS, CAT and gas electron multipliers. Essential improvements in the performance of the detectors were achieved especially in what concerned long-term performance: aging and resistance to accidental discharges.

  12. In-line phase sensitive amplifier based on PPLN waveguides.

    Science.gov (United States)

    Umeki, Takeshi; Asobe, Masaki; Takenouchi, Hirokazu

    2013-05-20

    We demonstrate a χ(2)-based in-line PSA with a carrier-recovery and phase-locking system for a phase shift keying (PSK) signal. By doubling the signal phase using a wavelength conversion technique, the carrier was recovered from a PSK signal. The carrier phase was synchronized to a local oscillator using optical injection locking. Phase sensitive amplification with a wide phase sensitive dynamic range of 20 dB was achieved using degenerate parametric amplification in a periodically poled LiNbO(3) (PPLN) waveguide. The phase regeneration effect was examined for a degraded signal by means of constellation analyses and bit-error rate measurements. The in-line PSA also operated successfully as a repeater amplifier in a 160 km fiber link without a power penalty. Finally, we demonstrate the regeneration of non-linear impairments induced by fiber non-linearity.

  13. Lensless microscope based on iterative in-line holographic reconstruction

    Science.gov (United States)

    Wu, Jigang

    2014-11-01

    We propose a lensless microscopic imaging technique based on iteration algorithm with known constraint for image reconstruction in digital in-line holography. In our method, we introduce a constraint on the sample plane as known part in the lensless microscopy for iteration algorithm in order to eliminate the twin-image effect of holography and thus lead to better performance on microscopic imaging. We evaluate our method by numerical simulation and built a prototype in-line holographic imaging system and demonstrated its capability by preliminary experiments. In our proposed setup, a carefully designed photomask used to hold the sample is under illumination of a coherent light source. The in-line hologram is then recorded by a CMOS sensor. In the reconstruction, the known information of the illumination beam and the photomask is used as constraints in the iteration process. The improvement of image quality because of suppression of twin-images can be clearly seen by comparing the images obtained by direct holographic reconstruction and our iterative method.

  14. Nozzle fabrication for Micro Propulsion of a Micro-Satellite

    NARCIS (Netherlands)

    Louwerse, M.C.; Jansen, Henricus V.; Groenendijk, M.N.W.; Elwenspoek, Michael Curt

    2008-01-01

    To enable formation flying of micro satellites, small sized propulsion systems are required. Our research focuses on the miniaturization of a feeding and thruster system by means of micro system technology (MST). Three fabrication methods have been investigated to make a conical converging-diverging

  15. A micro-coupling for micro mechanical systems

    Science.gov (United States)

    Li, Wei; Zhou, Zhixiong; Zhang, Bi; Xiao, Yunya

    2016-05-01

    The error motions of micro mechanical systems, such as micro-spindles, increase with the increasing of the rotational speed, which not only decreases the rotational accuracy, but also promotes instability and limits the maximum operational speed. One effective way to deal with it is to use micro-flexible couplings between the drive and driven shafts so as to reduce error motions of the driven shaft. But the conventional couplings, such as diaphragm couplings, elastomeric couplings, bellows couplings, and grooved couplings, etc, cannot be directly used because of their large and complicated structures. This study presents a novel micro-coupling that consists of a flexible coupling and a shape memory alloy (SMA)-based clamp for micro mechanical systems. It is monolithic and can be directly machined from a shaft. The study performs design optimization and provides manufacturing considerations, including thermo-mechanical training of the SMA ring for the desired Two-Way-Shape-Memory effect (TWSMe). A prototype micro-coupling and a prototype micro-spindle using the proposed coupling are fabricated and tested. The testing results show that the prototype micro-coupling can bear a torque of above 5 N • mm and an axial force of 8.5 N and be fitted with an SMA ring for clamping action at room temperature (15 °C) and unclamping action below-5 °C. At the same time, the prototype micro-coupling can work at a rotational speed of above 200 kr/min with the application to a high-speed precision micro-spindle. Moreover, the radial runout error of the artifact, as a substitute for the micro-tool, is less than 3 μm while that of turbine shaft is above 7 μm. It can be concluded that the micro-coupling successfully accommodates misalignment errors of the prototype micro-spindle. This research proposes a micro-coupling which is featured with an SMA ring, and it is designed to clamp two shafts, and has smooth transmission, simple assembly, compact structure, zero-maintenance and

  16. Micro rotary machine and methods for using same

    Science.gov (United States)

    Stalford, Harold L [Norman, OK

    2012-04-17

    A micro rotary machine may include a micro actuator and a micro shaft coupled to the micro actuator. The micro shaft comprises a horizontal shaft and is operable to be rotated by the micro actuator. A micro tool is coupled to the micro shaft and is operable to perform work in response to motion of the micro shaft.

  17. Micro Factory Systems and Tooling

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard

    2003-01-01

    The presentation deals with the micro factory concept in general and with the issues related to manufacturing, handling/assembly and quality control in particular.......The presentation deals with the micro factory concept in general and with the issues related to manufacturing, handling/assembly and quality control in particular....

  18. Micro Factory Systems and Tooling

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard

    2003-01-01

    The presentation deals with the micro factory concept in general and with the issues related to manufacturing, handling/assembly and quality control in particular.......The presentation deals with the micro factory concept in general and with the issues related to manufacturing, handling/assembly and quality control in particular....

  19. Micro-channel plate detector

    Science.gov (United States)

    Elam, Jeffrey W.; Lee, Seon W.; Wang, Hsien -Hau; Pellin, Michael J.; Byrum, Karen; Frisch, Henry J.

    2015-09-22

    A method and system for providing a micro-channel plate detector. An anodized aluminum oxide membrane is provided and includes a plurality of nanopores which have an Al coating and a thin layer of an emissive oxide material responsive to incident radiation, thereby providing a plurality of radiation sensitive channels for the micro-channel plate detector.

  20. Micro mixer with fast diffusion

    NARCIS (Netherlands)

    Miyake, Ryo; Miyake, R.; Lammerink, Theodorus S.J.; Elwenspoek, Michael Curt; Fluitman, J.H.J.

    1993-01-01

    A new concept for micro-mixing of liquid is introduced and feasibility is demonstrated. The mixer allows fast mixing of small amounts of two liquids and it is application to micro-liquid handling systems [1]. The mixer has a channel for the liquid, an inlet port for the reagent, and a 2.2 mm × 2 mm

  1. Wear of micro end mills

    DEFF Research Database (Denmark)

    Bissacco, Giuliano; Hansen, Hans Nørgaard; De Chiffre, Leonardo

    2005-01-01

    This paper addresses the important issue of wear on micro end mills considering relevant metrological tools for its characterization and quantification. Investigation of wear on micro end mills is particularly difficult and no data are available in the literature. Small worn volumes cause large d...

  2. In-line phase-contrast imaging for strong absorbing objects

    Energy Technology Data Exchange (ETDEWEB)

    De Caro, Liberato; Giannini, Cinzia [Istituto di Cristallografia, Consiglio Nazionale delle Ricerche (IC-CNR), via Amendola 122/O, I-70125 Bari (Italy); Cedola, Alessia; Bukreeva, Inna; Lagomarsino, Stefano [Istituto di Fotonica e Nanotecnologie, Consiglio Nazionale delle Ricerche (IFN-CNR), via Cinto Romano 42, I-00156 Roma (Italy)

    2008-11-21

    Phase-contrast imaging is one of the most important emerging x-ray imaging techniques. In this work we analyse, from a theoretical point of view, the in-line phase-contrast image formation under general assumptions. The approach is based on wave-optical theory (Fresnel/Kirchoff diffraction integrals) and on the formalism of the mutual coherence function for the evolution of the coherence wavefield properties. Our theoretical model can be applied to phase-contrast imaging realized both by using highly coherent synchrotron radiation and micro-focus x-ray laboratory sources. Thus, the model is suitable for widespread applications, ranging from material science to medical imaging of human body parts. However, it cannot be applied to polychromatic sources, although the validity of the model does not require particularly demanding characteristics of monochromaticity. In addition, for moderate phase gradients, a useful analytical formula of the phase-contrast visibility is derived, based on the a priori knowledge of source size and distance, pixel detector size, defocus distance, material/tissue dielectric susceptibility and characteristic scales of transversal and longitudinal non-uniformities of the material/tissue dielectric susceptibility. Comparisons both with experimental results published by other authors and with simulations based on a Fourier optics approach have been reported, to confirm the validity of the proposed analytical formula.

  3. Investigations on burning efficiency and exhaust emission of in-line type emulsified fuel system

    Energy Technology Data Exchange (ETDEWEB)

    Tseng, Y.K. [National Chinyi University of Technology (Taiwan). Dept. of Mechanical Engineering; Cheng, H.C. [Point Environmental Protection Technology Company Limited (Taiwan)

    2011-07-28

    In this research, the burning efficiency as well as exhaust emission of a new water-in-oil emulsified fuel system was studied. This emulsified system contains two core processes, the first one is to mix 97% water with 3% emulsifier by volume, and get the milk-like emulsified liquid, while the second one is to compound the milk-like emulsified liquid with heavy oil then obtain the emulsified fuel. In order to overcome the used demulsification problem during in reserve or in transport, this system was designed as a made and use in-line type. From the results of a series of burning tests, the fuel saving can be 8--15%. Also, from the comparison of decline for the heat value and total energy output of emulsified fuel, one can find that the water as the dispersed phase in the combustion process will lead to a micro-explosion as well as the water gas effect, both can raise the combustion temperature and burning efficiency. By comparing the waste gas emission of different types of emulsified fuel, one can know that, the CO2 emission reduces approximately 14%, and NOx emission reduces above 46%, meaning the reduction of the exhaust gas is truly effective. From the exhaust temperature of tail pipe, the waste heat discharge also may reduce 27%, it is quite advantageous to the global warming as well as earth environmental protection.

  4. Investigations on burning efficiency and exhaust emission of in-line type emulsified fuel system

    Directory of Open Access Journals (Sweden)

    Yen Kuei Tseng, Hsien Chang Cheng

    2011-07-01

    Full Text Available In this research, the burning efficiency as well as exhaust emission of a new water-in-oil emulsified fuel system was studied. This emulsified system contains two core processes, the first one is to mix 97% water with 3% emulsifier by volume, and get the milk-like emulsified liquid, while the second one is to compound the milk-like emulsified liquid with heavy oil then obtain the emulsified fuel. In order to overcome the used demulsification problem during in reserve or in transport, this system was designed as a made and use in-line type. From the results of a series burning tests, the fuel saving can be over 8~15%. Also, from the comparison of decline for the heat value and total energy output of varies emulsified fuel, one can find that the water as the dispersed phase in the combustion process will leading a micro-explosion as well as the water gas effect, both can raise the combustion temperature and burning efficiency. By comparing the waste gas emission of different types of emulsified fuel, one can know that, the CO2 emission reduces approximately 14%, and NOx emission reduces above 46%, that means the reduction of the exhaust gas is truly effectively. From the exhaust temperature of tail pipe, the waste heat discharge also may reduce 27%, it is quite advantageous to the global warming as well as earth environmental protection.

  5. Micro Environmental Concrete

    Science.gov (United States)

    Lanez, M.; Oudjit, M. N.; Zenati, A.; Arroudj, K.; Bali, A.

    Reactive powder concretes (RPC) are characterized by a particle diameter not exceeding 600 μm and having very high compressive and tensile strengths. This paper describes a new generation of micro concrete, which has an initial as well as a final high physicomechanical performance. To achieve this, 15% by weight of the Portland cement have been substituted by materials rich in Silica (Slag and Dune Sand). The results obtained from the tests carried out on the RPC show that compressive and tensile strengths increase when incorporating the addition, thus improving the compactness of mixtures through filler and pozzolanic effects. With a reduction in the aggregate phase in the RPC and the abundance of the dune sand (southern of Algeria) and slag (industrial by-product of the blast furnace), the use of the RPC will allow Algeria to fulfil economical as well as ecological requirements.

  6. MicroProteins

    DEFF Research Database (Denmark)

    Eguen, Teinai Ebimienere; Straub, Daniel; Graeff, Moritz;

    2015-01-01

    MicroProteins (miPs) are short, usually single-domain proteins that, in analogy to miRNAs, heterodimerize with their targets and exert a dominant-negative effect. Recent bioinformatic attempts to identify miPs have resulted in a list of potential miPs, many of which lack the defining...... characteristics of a miP. In this opinion article, we clearly state the characteristics of a miP as evidenced by known proteins that fit the definition; we explain why modulatory proteins misrepresented as miPs do not qualify as true miPs. We also discuss the evolutionary history of miPs, and how the miP concept...

  7. Micro pulse lidar

    Science.gov (United States)

    Spinhirne, James D.

    1993-01-01

    An eye safe, compact, solid state lidar for profiling atmospheric cloud and aerosol scattering has been demonstrated. The transmitter of the micropulse lidar is a diode pumped micro-J pulse energy, high repetition rate Nd:YLF laser. Eye safety is obtained through beam expansion. The receiver employs a photon counting solid state Geiger mode avalanche photodiode detector. Data acquisition is by a single card multichannel scaler. Daytime background induced quantum noise is controlled by a narrow receiver field-of-view and a narrow bandwidth temperature controlled interference filter. Dynamic range of the signal is limited by optical geometric signal compression. Signal simulations and initial atmospheric measurements indicate that systems built on the micropulse lidar concept are capable of detecting and profiling all significant cloud and aerosol scattering through the troposphere and into the stratosphere. The intended applications are scientific studies and environmental monitoring which require full time, unattended measurements of the cloud and aerosol height structure.

  8. [MicroRNAs in neurobiology].

    Science.gov (United States)

    Kawahara, Yukio

    2008-12-01

    MicroRNAs have emerged as a new regulatory factor of gene expression. They mediate translational repression or degradation of their target mRNAs by RNA interference (RNAi). The expression of each microRNA is tightly regulated in a development- and cell-specific manner by various mechanisms such as blockade of let-7 family expression by Lin-28 or RNA editing. They also act as regulatory switches for development, organogenesis, and cellular differentiation or for controlling distinct functions that are required for the maintenance of each tissue and cell subtypes. The abundant expression of microRNAs as well as the exclusive expression of certain microRNAs in the central nervous system highlights their biological importance at all stages of neural development and in postmitotic and differentiated neurons. Further, some microRNAs, such as miRNA-134, and miRNA-132 are localized and are synthesized in part at synaptic sites in dendrites to regulate synaptic formation and plasticity. In addition to the imparting of basic knowledge about the biogenesis and mechanism of action of microRNAs, this review focuses on the recent advances in microRNA studies in neurobiology, including the expression pattern of microRNAs in the mammalian brain, the role of microRNAs in neural differentiation and maturation, formation and plasticity of synaptic connections, and maintenance of neural function such as the synthesis of the neurotransmitters in selected neurons. Finally, the possible connection between microRNA dysfunction and neurological diseases, and future implications for diagnosis, and treatment of defects in human brain development and neurodegenerative diseases are discussed.

  9. Microbial population dynamics by digital in-line holographic microscopy

    Science.gov (United States)

    Frentz, Zak; Kuehn, Seppe; Hekstra, Doeke; Leibler, Stanislas

    2010-08-01

    Measurements of population dynamics are ubiquitous in experiments with microorganisms. Studies with microbes elucidating adaptation, selection, and competition rely on measurements of changing populations in time. Despite this importance, quantitative methods for measuring population dynamics microscopically, with high time resolution, across many replicates remain limited. Here we present a new noninvasive method to precisely measure microbial spatiotemporal population dynamics based on digital in-line holographic (DIH) microscopy. Our inexpensive, replicate DIH microscopes imaged hundreds of swimming algae in three dimensions within a volume of several microliters on a time scale of minutes over periods of weeks.

  10. Particle digital in-line holography with spherical wave recording

    Institute of Scientific and Technical Information of China (English)

    Baozhen Ge(葛宝臻); Qieni Lü(吕且妮); Yimo Zhang(张以谟)

    2003-01-01

    In this paper, we propose a method of digital in-line holography of particle. A diverging spherical beam is used for illumination in recording hologram, the complex amplitude distribution generated by particle field at a single plane located in the Fresnel diffraction region is recorded by CCD, and a plane beam for reconstructing hologram, then, the magnified image can be obtained by numerical reconstruction in computer. This procedure can be interpreted by Fourier optical theory and the theoretical analysis have been done in detail, the experimental results, the air freshener being subject, are also given.

  11. Mobile Deals Set to Lure Shoppers Stuck in Line

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    @@ According to New York Times on November 19, as retailers battle to draw customers into their stores on Black Friday, online merchants are plotting a cunning ambush, offering an arsenal of mobile-only deals intended to pick off shoppers as they wait in line. The Gilt Groupe, for example, which operates several Web sites, usually offers sales at noon.But on Friday, it will promote mobile exclusives at 6 a.m., precisely when shoppers are expected to be crammed into checkout lines at some of its high-end competitors.

  12. Microbial population dynamics by digital in-line holographic microscopy.

    Science.gov (United States)

    Frentz, Zak; Kuehn, Seppe; Hekstra, Doeke; Leibler, Stanislas

    2010-08-01

    Measurements of population dynamics are ubiquitous in experiments with microorganisms. Studies with microbes elucidating adaptation, selection, and competition rely on measurements of changing populations in time. Despite this importance, quantitative methods for measuring population dynamics microscopically, with high time resolution, across many replicates remain limited. Here we present a new noninvasive method to precisely measure microbial spatiotemporal population dynamics based on digital in-line holographic (DIH) microscopy. Our inexpensive, replicate DIH microscopes imaged hundreds of swimming algae in three dimensions within a volume of several microliters on a time scale of minutes over periods of weeks.

  13. Sustainable Micro-Manufacturing of Micro-Components via Micro Electrical Discharge Machining

    Directory of Open Access Journals (Sweden)

    Valeria Marrocco

    2011-12-01

    Full Text Available Micro-manufacturing emerged in the last years as a new engineering area with the potential of increasing peoples’ quality of life through the production of innovative micro-devices to be used, for example, in the biomedical, micro-electronics or telecommunication sectors. The possibility to decrease the energy consumption makes the micro-manufacturing extremely appealing in terms of environmental protection. However, despite this common belief that the micro-scale implies a higher sustainability compared to traditional manufacturing processes, recent research shows that some factors can make micro-manufacturing processes not as sustainable as expected. In particular, the use of rare raw materials and the need of higher purity of processes, to preserve product quality and manufacturing equipment, can be a source for additional environmental burden and process costs. Consequently, research is needed to optimize micro-manufacturing processes in order to guarantee the minimum consumption of raw materials, consumables and energy. In this paper, the experimental results obtained by the micro-electrical discharge machining (micro-EDM of micro-channels made on Ni–Cr–Mo steel is reported. The aim of such investigation is to shed a light on the relation and dependence between the material removal process, identified in the evaluation of material removal rate (MRR and tool wear ratio (TWR, and some of the most important technological parameters (i.e., open voltage, discharge current, pulse width and frequency, in order to experimentally quantify the material waste produced and optimize the technological process in order to decrease it.

  14. In-line acid concentration measuring method and measuring probe

    Energy Technology Data Exchange (ETDEWEB)

    Kuno, Takehiko; Kurosawa, Akira; Sato, Soichi

    1998-09-11

    A measuring probe comprising an electrode for voltammetry, a supersonic sensor and a conductivity measuring electrode formed integrally is immersed in a solution for a reprocessing step. A relationship between an acid concentration of the solution having U and Pu concentrations as variable parameters and a propagation speed of supersonic waves in the solution is previously determined, and a propagation speed of the supersonic waves in the solution for the reprocessing step is measured. An acid concentration is determined by using U and Pu concentrations of the solution of the reprocessing step measured in-line by using voltammetry based on the relationship between the acid concentration at that U and Pu concentrations and the supersonic propagation speed. In addition, conductivity of the liquid for the step is measured by a solution conductivity meter, and an acid concentration is measured in-line based on the relationship between the acid concentration and the conductivity in the same manner. With such procedures, a reprocessing plant can be operated rapidly and smoothly, as well as the analysis operation can be simplified. (T.M.)

  15. Towards Fast In-line Measurement of Water Activity

    Science.gov (United States)

    Nielsen, J.; Andreasen, M. B.; Pedersen, M.; Rasmussen, M. K.

    2015-03-01

    Water activity is widely used as a key parameter in controlling the quality of food and feed products, among others. For determining the water activity, the material is sampled from the manufacturing process and measured in the laboratory with water activity analyzers. The sampling procedure can lead to non-representative measurements, the measurement process is time consuming, and much of the produced material may be wasted before the measurement results are available. To reduce waste and to be able to optimize production processes, industry requires in-line measurement of relevant quality determining parameters, hereunder the water activity. In cooperation with a manufacturer of systems for automatic in-line sampling and measurement of moisture, density, and the size of items, a project was defined to also enable the manufacturer's existing products to perform automatic measurement of the water activity in a sample. The aim was to develop a measurement system with the ability to operate in an industrial environment, which in the end would increase the measurement speed significantly and minimize the problems related to the handling of samples. In the paper the selection and characterization of the sensors, the design of a measurement chamber, and various issues of modeling and methods to reduce measurement time are discussed. The paper also presents water activity measurements obtained from food and feed products with the system, and shows that reliable results can be obtained in a few minutes with a proper design of the measurement chamber and selection of a model.

  16. Micro Injection Moulding of Polymeric Components

    Science.gov (United States)

    Trotta, G.; Surace, R.; Modica, F.; Spina, R.; Fassi, I.

    2011-01-01

    Micro components and micro devices are strongly used in several fields: IT components, biomedical and medical products, automotive industry, telecommunication area and aerospace. A micro component is characterized by small dimensions of the product itself or small dimensions of the functional features. The development of new micro parts is highly dependent on manufacturing systems that can reliably and economically produce micro components in large quantities. In this context, micro-electrical discharge machining (EDM) for mould production and micro-injection moulding of polymer materials are the key technologies for micro manufacturing. This paper will focus on the production and quality evaluation of polymeric micro components manufactured by micro injection moulding. In particular the authors want to investigate the process parameters on the overall quality of the product. The factors affecting micro flow behavior, components weights and dimension definition are experimentally studied basing on DoE approach and then discussed.

  17. Micro-mixer/combustor

    KAUST Repository

    Badra, Jihad Ahmad

    2014-09-18

    A micro-mixer/combustor to mix fuel and oxidant streams into combustible mixtures where flames resulting from combustion of the mixture can be sustained inside its combustion chamber is provided. The present design is particularly suitable for diffusion flames. In various aspects the present design mixes the fuel and oxidant streams prior to entering a combustion chamber. The combustion chamber is designed to prevent excess pressure to build up within the combustion chamber, which build up can cause instabilities in the flame. A restriction in the inlet to the combustion chamber from the mixing chamber forces the incoming streams to converge while introducing minor pressure drop. In one or more aspects, heat from combustion products exhausted from the combustion chamber may be used to provide heat to at least one of fuel passing through the fuel inlet channel, oxidant passing through the oxidant inlet channel, the mixing chamber, or the combustion chamber. In one or more aspects, an ignition strip may be positioned in the combustion chamber to sustain a flame without preheating.

  18. Levitated micro-accelerometer.

    Energy Technology Data Exchange (ETDEWEB)

    Warne, Larry Kevin; Schmidt, Carrie Frances; Peterson, Kenneth Allen; Kravitz, Stanley H.; Renn, Rosemarie A.; Peter, Frank J.; Kinney, Ragon D.; Gilkey, Jeffrey C.

    2004-06-01

    The objective is a significant advancement in the state-of-the-art of accelerometer design for tactical grade (or better) applications. The design goals are <1 milli-G bias stability across environments and $200 cost. This quantum leap in performance improvement and cost reduction can only be achieved by a radical new approach, not incremental improvements to existing concepts. This novel levitated closed-loop accelerometer is implemented as a hybrid micromachine. The hybrid approach frees the designer from the limitations of any given monolithic process and dramatically expands the available design space. The design can be tailored to the dynamic range, resolution, bandwidth, and environmental requirements of the application while still preserving all of the benefits of monolithic MEMS fabrication - extreme precision, small size, low cost, and low power. An accelerometer was designed and prototype hardware was built, driving the successful development and refinement of several 'never been done before' fabrication processes. Many of these process developments are commercially valuable and are key enablers for the realization of a wide variety of useful micro-devices. While controlled levitation of a proof mass has yet to be realized, the overall design concept remains sound. This was clearly demonstrated by the stable and reliable closed-loop control of a proof mass at the test structure level. Furthermore, the hybrid MEMS implementation is the most promising approach for achieving the ambitious cost and performance targets. It is strongly recommended that Sandia remain committed to the original goal.

  19. MicroRNA and cancer

    National Research Council Canada - National Science Library

    Jansson, Martin D; Lund, Anders H

    2012-01-01

    .... The best characterized non‐coding RNA family consists in humans of about 1400 microRNAs for which abundant evidence have demonstrated fundamental importance in normal development, differentiation, growth control and in human...

  20. Nitrous Oxide Micro Engines Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Nitrous Oxide Micro Engines (NOME) are a new type of nitrous oxide dissociation thruster designed to generate low levels of thrust that can be used for RCS control...

  1. Micro-gen metering solutions

    Energy Technology Data Exchange (ETDEWEB)

    Elland, J.; Dickson, J.; Cranfield, P.

    2003-07-01

    This report summarises the results of a project to investigate the regulation of domestic electricity metering work and identify the most economic options for micro-generator installers to undertake work on electricity meters. A micro-generation unit is defined as an energy conversion system converting non-electrical energy into electrical energy and can include technologies such as photovoltaic systems, small-scale wind turbines, micro-hydroelectric systems, and combined heat and power systems. Details of six tasks are given and cover examination of the existing framework and legal documentation for metering work, the existing technical requirements for meter operators, meter operator personnel accreditation, appraisal of options for meter changes and for micro-generation installation, document change procedures, industry consultation, and a review of the costs implications of the options.

  2. Highly Efficient Micro Cathode Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Busek Company, Inc. proposes to develop a micro thermionic cathode that requires extremely low power and provides long lifetime. The basis for the cathode is a...

  3. Accurate in-line CD metrology for nanometer semiconductor manufacturing

    Science.gov (United States)

    Perng, Baw-Ching; Shieh, Jyu-Horng; Jang, S.-M.; Liang, M.-S.; Huang, Renee; Chen, Li-Chien; Hwang, Ruey-Lian; Hsu, Joe; Fong, David

    2006-03-01

    The need for absolute accuracy is increasing as semiconductor-manufacturing technologies advance to sub-65nm nodes, since device sizes are reducing to sub-50nm but offsets ranging from 5nm to 20nm are often encountered. While TEM is well-recognized as the most accurate CD metrology, direct comparison between the TEM data and in-line CD data might be misleading sometimes due to different statistical sampling and interferences from sidewall roughness. In this work we explore the capability of CD-AFM as an accurate in-line CD reference metrology. Being a member of scanning profiling metrology, CD-AFM has the advantages of avoiding e-beam damage and minimum sample damage induced CD changes, in addition to the capability of more statistical sampling than typical cross section metrologies. While AFM has already gained its reputation on the accuracy of depth measurement, not much data was reported on the accuracy of CD-AFM for CD measurement. Our main focus here is to prove the accuracy of CD-AFM and show its measuring capability for semiconductor related materials and patterns. In addition to the typical precision check, we spent an intensive effort on examining the bias performance of this CD metrology, which is defined as the difference between CD-AFM data and the best-known CD value of the prepared samples. We first examine line edge roughness (LER) behavior for line patterns of various materials, including polysilicon, photoresist, and a porous low k material. Based on the LER characteristics of each patterning, a method is proposed to reduce its influence on CD measurement. Application of our method to a VLSI nanoCD standard is then performed, and agreement of less than 1nm bias is achieved between the CD-AFM data and the standard's value. With very careful sample preparations and TEM tool calibration, we also obtained excellent correlation between CD-AFM and TEM for poly-CDs ranging from 70nm to 400nm. CD measurements of poly ADI and low k trenches are also

  4. Fiber Sensing of Micro -Crack

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Optical fiber sensors are used for sensing micro-cracking in composite and metal materials in aerospace applications. The sensing mechanism is based on the detection of acoustic emission signals, which are known to emanate from micro-cracks when they grow under further loading. The sensor head consists of a fiber Bragg grating that is capable of detecting acoustic emission signals generated by pencil lead breaking, of frequencies up to 200 kHz.

  5. Low-drift micro flow sensors

    NARCIS (Netherlands)

    Dijkstra, Marcel

    2009-01-01

    The emerging fields of micro total-analysis systems (micro-TAS), micro-reactors and bio-MEMS drives the need for further miniaturisation of sensors measuring quantities such as pressure, temperature and flow. The research described in this thesis concerns the development of low-drift micro flow sens

  6. SMART micro-scissors based precise incision

    Science.gov (United States)

    Park, Hyun-Cheol; Yeo, Chaebeom; Song, Cheol

    2015-03-01

    Hand tremor reduction is important to achieve stable micro manipulation of the tool tip. A micro-scissors can be used for cutting delicate tissues safely. Here, we implement an OCT distance sensor guided SMART micro-scissors which could incise micro-surgical targets precisely and horizontally. Compared to freehand incision, it demonstrates enhanced incision performance on dry phantoms with great tremor suppression.

  7. Visualization of microvasculature by x-ray in-line phase contrast imaging in rat spinal cord

    Science.gov (United States)

    Hu, Jian-Zhong; Wu, Tian-Ding; Zeng, Lei; Liu, Hui-Qiang; He, You; Du, Guo-Hao; Lu, Hong-Bin

    2012-03-01

    Computed tomography combined with angiography has recently been developed to visualize three-dimensional (3D) vascular structure in experi-mental and clinical studies. However, there remain difficulties in using conventional x-ray angiography to detect small vessels with a diameter less than 200 µm. This study attempted to develop a novel method for visualizing the micro-angioarchitecture of rat spinal cord. Herein, synchrotron radiation-based x-ray in-line phase contrast computed tomography (IL-XPCT) was used to obtain 3D micro-vessel structure without angiography. The digital phase contrast images were compared with conventional histological sections. Our results clearly demonstrated that the resolution limit of the spatial blood supply network in the normal rat thoracic cord appeared to be as small as ∼10 µm. The rendered images were consistent with that obtained from histo-morphology sections. In summary, IL-XPCT is a potential tool to investigate the 3D neurovascular morphology of the rat spinal cord without the use of contrast agents, and it could help to evaluate the validity of the pro- or anti-angiogenesis therapeutic strategies on microvasculature repair or regeneration.

  8. Flow Induced Acoustic Resonance in In-line Tube Banks

    Institute of Scientific and Technical Information of China (English)

    Hiromitsu Hamakawa; Tohru Fukano; Eiichi Nishida; Yoshikazu Satou

    2006-01-01

    In the present paper the attention is focused on the relation between vortex shedding phenomena and acoustic resonance which occurred in the two-dimensional model of boiler. There were tube banks with in-line arrangement for small tube pitch ratio. We measured the sound pressure level, the phase delay of acoustic pressures, the spectrum of velocity fluctuation and the gap velocity. As a result, we found two peak frequencies of sound pressure level with different Strouhal numbers St, mainly about 0.26 and 0.52. The noise of St=0.26 was the resonance of transverse mode and St=0.52 was longitudinal mode. The vortex shedding of St=0.15 was generated inside the tube banks without acoustic resonance. As gap velocity increased, we observed that the peak level of spectrum was weak and broad-banded. The onset velocity of the acoustic resonance of longitudinal mode was lower than that of transverse mode.

  9. In-line balanced detection stimulated Raman scattering microscopy

    KAUST Repository

    Crisafi, Francesco

    2017-08-31

    We introduce a novel configuration for stimulated Raman scattering (SRS) microscopy, called In-line Balanced Detection (IBD), which employs a birefringent plate to generate a time-delayed polarization-multiplexed collinear replica of the probe, acting as a reference. Probe and reference cross the sample at the same position, thus maintaining their balance during image acquisition. IBD can be implemented in any conventional SRS setup, by adding a few simple elements, bringing its sensitivity close to the shot-noise limit even with a noisy laser. We tested IBD with a fiber-format laser system and observed signal-to-noise ratio improvement by up to 30 dB.

  10. Reliability of materials in MEMS : residual stress and adhesion in a micro power generation system.

    Energy Technology Data Exchange (ETDEWEB)

    Moody, Neville Reid; Kennedy, Marian S. (Washington State University, Pullman, WA); Bahr, David F. (Washington State University, Pullman, WA)

    2007-09-01

    The reliability of thin film systems is important to the continued development of microelectronic and micro-electro-mechanical systems (MEMS). The reliability of these systems is often tied to the ability of the films to remain adhered to its substrate. By measuring the amount of energy to separate the film from the substrate, researchers can predicts film lifetimes. Recent work has resulted in several different testing techniques to measure this energy including spontaneous buckling, indentation induced delamination and four point bending. This report focuses on developing quantifiable adhesion measurements for multiple thin film systems used in MEMS and other thin film systems of interest to Sandia programs. First, methods of accurately assessing interfacial toughness using stressed overlayer methods are demonstrated using both the W/Si and Au/Si systems. For systems where fracture only occurs along the interface, such as Au/Si, the calculated fracture energies between different tests are identical if the energy put into the system is kept near the needed strain energy to cause delamination. When the energy in the system is greater than needed to cause delamination, calculated adhesion energies can increase by a factor of three due to plastic deformation. Dependence of calculated adhesion energies on applied energy in the system was also shown when comparisons of four point bending and stressed overlayer test methods were completed on Pt/Si systems. The fracture energies of Pt/Ti/SiO{sub 2} were studied using four-point bending and compressive overlayers. Varying the thickness of the Ti film from 2 to 17 nm in a Pt/Ti/SiO{sub 2} system, both test methods showed an increase of adhesion energy until the nominal Ti thickness was 12nm. Then the adhesion energy began to decrease. While the trends in toughness are similar, the magnitude of the toughness values measured between the test methods is not the same, demonstrating the difficulty in extracting mode I toughness

  11. Terahertz in-line digital holographic multiplane imaging method

    Science.gov (United States)

    Huang, Haochong; Wang, Dayong; Rong, Lu; Li, Weihua; Wang, Yunxin

    2017-05-01

    Terahertz waves of which frequency spans from 0.1 to 10 THz bridge the gap between the infrared spectrum and microwaves. Owing to the special features of terahertz wave, such as penetrability and non-ionizing, terahertz imaging technique is a very significant and important method for inspections and detections. Digital holography can reconstruct the amplitude and phase distributions of a sample without scanning and it already has many successful applications in the area of visible and infrared light. The terahertz in-line digital holographic multi-plane imaging system which is presented in this paper is the combination of a continuous-wave terahertz source and the in-line scheme of digital holography. In order to observe a three dimensional (3D) shape sample only a portion of which appears in good focus, the autofocusing algorithm is brought to the data process. The synthetic aperture method is also applied to provide the high resolution imaging effect in the terahertz waveband. Both intrinsic twin images and defocused objective images confuse the quality of the image in an individual reconstructed plane. In order to solve this issue, phase retrieval iteration algorithm is used for the reconstruction. In addition, the reconstructed amplitude image in each plane multiplies the mask of which the threshold depends on the values of the autofocusing curve. A sample with simple artificial structure is observed which verifies that the present method is an authentic tool to acquire the multi-plane information of a target in terahertz waves. It can expect a wide application in terahertz defect detecting, terahertz medical inspection and other important areas in the future.

  12. In-line digital holography with double knife edge

    Science.gov (United States)

    Ramirez, Claudio; Iemmi, Claudio; Campos, Juan

    2015-06-01

    We study and test a new technique for in-line digital holography which avoids the formation of the conjugate images. Inline digital holography is based in a common path configuration. In this case, the hologram is produced by the interference between the reference wave front and the diffracted wave front by an almost transparent object. Twin images are obtained with obscured rings that difficult the determination of the best focusing plane. To avoid the conjugated image, the information of the magnitude and phase of the wave front are needed. In a recent work a new in-line digital holography technique was proposed. In this method the object is illuminated with a collimated wave front. A plane, close to the particles distribution is imaged onto a CCD by means of a convergent lens and at the same time, a knife edge is placed in the focal plane of the lens in order to block half of spatial frequency spectrum. In this way, by means of a numerical processing performed on the Fourier plane, it is possible to eliminate one of the components (real or conjugate) of the reconstructed images nevertheless it is observed a tiny deformation of the resulting hologram image. To compensate this effect, we propose a new configuration in which we implement the knife edge technique on both parts of the spectrum at the same time. Finally in the computer, we process the holograms to build one complete without deformation. This hologram is used to recover the wave front at different planes without the influence of the conjugate image.

  13. Analysis of micro-forces between micro-parts and their influence factors in MEMS

    Institute of Scientific and Technical Information of China (English)

    LI Gui-xian; PENG Yun-feng; ZHANG Xin

    2008-01-01

    The research of micro-forces between micro-parts forms the base for micro-machine (MEMS) devel-opment. According to the characteristics of the interactions between micro-parts in MEMS, three models were simplified. Based on these models, micro-forces between micro-parts were analyzed, and the analytical formulas were formulated. Factors which may affect the micro-forces, such as surface condition, media and constitutive material of micro-parts were discussed. A coefficient of surface roughness on micro-forces was introduced,which facilitated the analysis of the influence of surface roughness.

  14. 21 CFR 870.4410 - Cardiopulmonary bypass in-line blood gas sensor.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cardiopulmonary bypass in-line blood gas sensor... Cardiopulmonary bypass in-line blood gas sensor. (a) Identification. A cardiopulmonary bypass in-line blood gas sensor is a transducer that measures the level of gases in the blood. (b) Classification. Class II...

  15. Micro-droplet formation via 3D printed micro channel

    Science.gov (United States)

    Jian, Zhen; Zhang, Jiaming; Li, Erqiang; Thoroddsen, Sigurdur T.

    2016-11-01

    Low cost, fast-designed and fast-fabricated 3D micro channel was used to create micro-droplets. Capillary with an outer diameter of 1.5 mm and an inner diameter of 150 μm was inserted into a 3D printed cylindrical channel with a diameter of 2 mm . Flow rate of the two inlets, insert depth, liquid (density, viscosity and surface tension) and solid (roughness, contact angle) properties all play a role in the droplet formation. Different regimes - dripping, jetting, unstable state - were observed in the micro-channel on varying these parameters. With certain parameter combinations, successive formation of micro-droplets with equal size was observed and its size can be much smaller than the smallest channel size. Based on our experimental results, the droplet formation via 3D printed micro T-junction was investigated through direct numerical simulations with a code called Gerris. Reynolds numbers Re = ρUL / μ and Weber numbers We = ρU2 L / σ of the two liquids were introduced to measure the liquid effect. The parameter regime where different physical dynamics occur was studied and the regime transition was observed with certain threshold values. Qualitative and quantitative analysis were performed as well between simulations and experiments.

  16. 微纳薄膜器件的电阻率精确测量方法%Method for Accurate Measurement of Micro-Nano Thin Film Device Resistivity

    Institute of Scientific and Technical Information of China (English)

    吴蕾; 居冰峰; 杨春晖; 林军

    2012-01-01

    微纳级别的铝薄膜因宽度和厚度尺寸缩小其试件尺寸接近电极的最小间距、电极间的位置误差等因素的影响,导致电阻率四电极法在测量过程中产生较大的误差.通过对微纳级的导电薄膜的四电极测量法进行数学建模分析,建立了新的四电极测量法数学计算模型,提供精确的电阻率修正系数,并利用基于原子力显微镜的四电极电阻率测量技术精确测量了厚度为400 nm、宽度为30 μm的铝薄膜的电阻率,且取不同的作用力重复实验.实验结果证明,基于修正后数学模型的微四电极技术对微纳级别薄膜的电阻率测量方面的准确性和稳定性.%Because of the width and thickness of the micro-nano thin film is very close to the minimum distance of the electrodes and the position error between electrodes, which led to errors during the measurement process using the four-point-probe. By analyzing the traditional four-point-probe method, a new four-point-probe method model for measurement of micron-nano aluminum thin film' s resistivity was created. The four-point-AFM-probe technique was applied for the purpose of quantitatively measuring resistivity of the aluminum film with 400 nm thickness and 30 祄 width. The repeatability of resistivity measurements indicates that this new four-point-probe model technique could be used for fast in situ cha racterization of electrical properties of micro-nano thin film.

  17. Micro-range micro-doppler for dismount classification

    Science.gov (United States)

    Tahmoush, Dave

    2013-05-01

    This paper presents a processing technique that can be used to detect and classify pedestrians group based on the micro- Doppler signature gathered with a millimeter wave radar. The evaluation of the number of pedestrians moving in a group can be a difficult task using a traditional micro-Doppler spectrogram because of a tendency for people to partially synchronize their steps when walking together. The new approach, based on multi-range variation as well as the micro-Doppler variations, provides promising results. The range-spectrogram processing technique was developed and tested using a database composed of hundreds of pedestrian and vehicle signatures gathered in an urban test site over a two year period in a variety of weather conditions. We associate image detections with radar detections through motion extracted from both radar and imagery. We also explain how radar and video together can produce an inexpensive alternative to 3-D imaging.

  18. Tunable Micro- and Nanomechanical Resonators

    Science.gov (United States)

    Zhang, Wen-Ming; Hu, Kai-Ming; Peng, Zhi-Ke; Meng, Guang

    2015-01-01

    Advances in micro- and nanofabrication technologies have enabled the development of novel micro- and nanomechanical resonators which have attracted significant attention due to their fascinating physical properties and growing potential applications. In this review, we have presented a brief overview of the resonance behavior and frequency tuning principles by varying either the mass or the stiffness of resonators. The progress in micro- and nanomechanical resonators using the tuning electrode, tuning fork, and suspended channel structures and made of graphene have been reviewed. We have also highlighted some major influencing factors such as large-amplitude effect, surface effect and fluid effect on the performances of resonators. More specifically, we have addressed the effects of axial stress/strain, residual surface stress and adsorption-induced surface stress on the sensing and detection applications and discussed the current challenges. We have significantly focused on the active and passive frequency tuning methods and techniques for micro- and nanomechanical resonator applications. On one hand, we have comprehensively evaluated the advantages and disadvantages of each strategy, including active methods such as electrothermal, electrostatic, piezoelectrical, dielectric, magnetomotive, photothermal, mode-coupling as well as tension-based tuning mechanisms, and passive techniques such as post-fabrication and post-packaging tuning processes. On the other hand, the tuning capability and challenges to integrate reliable and customizable frequency tuning methods have been addressed. We have additionally concluded with a discussion of important future directions for further tunable micro- and nanomechanical resonators. PMID:26501294

  19. Micro Machining Enhances Precision Fabrication

    Science.gov (United States)

    2007-01-01

    Advanced thermal systems developed for the Space Station Freedom project are now in use on the International Space Station. These thermal systems employ evaporative ammonia as their coolant, and though they employ the same series of chemical reactions as terrestrial refrigerators, the space-bound coolers are significantly smaller. Two Small Business Innovation Research (SBIR) contracts between Creare Inc. of Hanover, NH and Johnson Space Center developed an ammonia evaporator for thermal management systems aboard Freedom. The principal investigator for Creare Inc., formed Mikros Technologies Inc. to commercialize the work. Mikros Technologies then developed an advanced form of micro-electrical discharge machining (micro-EDM) to make tiny holes in the ammonia evaporator. Mikros Technologies has had great success applying this method to the fabrication of micro-nozzle array systems for industrial ink jet printing systems. The company is currently the world leader in fabrication of stainless steel micro-nozzles for this market, and in 2001 the company was awarded two SBIR research contracts from Goddard Space Flight Center to advance micro-fabrication and high-performance thermal management technologies.

  20. Tunable Micro- and Nanomechanical Resonators

    Directory of Open Access Journals (Sweden)

    Wen-Ming Zhang

    2015-10-01

    Full Text Available Advances in micro- and nanofabrication technologies have enabled the development of novel micro- and nanomechanical resonators which have attracted significant attention due to their fascinating physical properties and growing potential applications. In this review, we have presented a brief overview of the resonance behavior and frequency tuning principles by varying either the mass or the stiffness of resonators. The progress in micro- and nanomechanical resonators using the tuning electrode, tuning fork, and suspended channel structures and made of graphene have been reviewed. We have also highlighted some major influencing factors such as large-amplitude effect, surface effect and fluid effect on the performances of resonators. More specifically, we have addressed the effects of axial stress/strain, residual surface stress and adsorption-induced surface stress on the sensing and detection applications and discussed the current challenges. We have significantly focused on the active and passive frequency tuning methods and techniques for micro- and nanomechanical resonator applications. On one hand, we have comprehensively evaluated the advantages and disadvantages of each strategy, including active methods such as electrothermal, electrostatic, piezoelectrical, dielectric, magnetomotive, photothermal, mode-coupling as well as tension-based tuning mechanisms, and passive techniques such as post-fabrication and post-packaging tuning processes. On the other hand, the tuning capability and challenges to integrate reliable and customizable frequency tuning methods have been addressed. We have additionally concluded with a discussion of important future directions for further tunable micro- and nanomechanical resonators.

  1. [MicroRNAs and kidneys].

    Science.gov (United States)

    Stříteská, Jana; Nekvindová, Jana; Cerný, Vladimír; Palička, Vladimír

    2014-01-01

    MicroRNAs are short non-coding ribonucleic acid molecules that regulate gene expression at the post-transcriptional level thus affecting important physiological as well as pathophysiological processes in the organism, for example cell differentiation, proliferation, apoptosis, and metabolism. They are involved in pathogenesis of many diseases including cancer. Many microRNAs are tissue or organ-specific which implies their possible potential as biomarkers or maybe even therapeutical agents as documented by microRNA research interest rising exponentially during last years. Among all, microRNAs are important also for physiological function of the kidney and they are involved in various renal disorders. Today research is focused mainly on renal and urinary tract carcinogenesis, acute kidney injury, chronic renal diseases (polycystic kidney disease) or renal complications of systemic diseases such as diabetic or hypertension nephropathy and autoimmune kidney injury including acute allograft rejection after kidney transplantation. The review summarizes current information about microRNA effect on kidney development and function and also on the most common kidney diseases.

  2. Equivalent Simplification Method of Micro-Grid

    Directory of Open Access Journals (Sweden)

    Cai Changchun

    2013-09-01

    Full Text Available The paper concentrates on the equivalent simplification method for the micro-grid system connection into distributed network. The equivalent simplification method proposed for interaction study between micro-grid and distributed network. Micro-grid network, composite load, gas turbine synchronous generation, wind generation are equivalent simplification and parallel connect into the point of common coupling. A micro-grid system is built and three phase and single phase grounded faults are performed for the test of the equivalent model of micro-grid. The simulation results show that the equivalent model of micro-grid is effective, and the dynamic of equivalent model is similar with the detailed model of micro-grid. The equivalent simplification method for the micro-grid network and distributed components is suitable for the study of micro-grid.  

  3. Numerical analysis of elastic coated solids in line contact

    Institute of Scientific and Technical Information of China (English)

    王廷剑; 王黎钦; 古乐; 赵小力

    2015-01-01

    A line contact model of elastic coated solids is presented based on the influence coefficients (ICs) of surface displacement and stresses of coating−substrate system and the traditional contact model. The ICs of displacement and stresses are obtained from their corresponding frequency response functions (FRF) by using a conversion method based on fast Fourier transformation (FFT). The contact pressure and the stress field in the subsurface are obtained by employing conjugate gradient method (CGM) and discrete convolution fast Fourier transformation (DC-FFT). Comparison of the contact pressure and subsurface stresses obtained by the numerical method with the exact analytical solutions for Hertz contact is conducted, and the results show that the numerical solution has a very high accuracy and verify the validity of the contact model. The effect of the stiffness and thickness of coatings is further numerically studied. The result shows that the effects on contact pressure and contact width are opposite for hard and soft coatings and are intensified with the increase of coating thickness; the locations of crack initiation and propagation are different for soft and hard coatings; the risk of cracks and delaminations of coatings can be brought down by improving the lubrication condition or optimizing the non-dimensional parameterh/bh. This research offers a tool to numerically analyze the problem of elastic coated solids in line contact and make the blindness and randomness of trial-type coating design less.

  4. Improved pinning by multiple in-line damage

    Energy Technology Data Exchange (ETDEWEB)

    Weinstein, Roy [Beam Particle Dynamics Laboratories, University of Houston, Houston, TX 77204-5005 (United States); Sawh, Ravi-Persad [Beam Particle Dynamics Laboratories, University of Houston, Houston, TX 77204-5005 (United States); Gandini, Alberto [Beam Particle Dynamics Laboratories, University of Houston, Houston, TX 77204-5005 (United States); Parks, Drew [Beam Particle Dynamics Laboratories, University of Houston, Houston, TX 77204-5005 (United States)

    2005-02-01

    Columnar pinning centres provide the largest pinning potential, U{sub pin}, but not the greatest J{sub c} or pinnable field, B{sub pin}. Characteristics of ion-generated columnar defects which limit J{sub c} and B{sub pin} are discussed, including reduction of the percolation path, and the need for a larger number of columns of damage, for pinning, than are usually estimated. It is concluded that columnar pinning centres limit B{sub pin} to less than 4 T, and also severely reduce J{sub c}. The goal of maximizing U{sub pin}, via columnar centres, appears to have obscured a more rewarding approach and resulted in neglect of a large regime of ion interactions. Evidence is reviewed that multiple in-line damage (MILD), described herein, can provide orders of magnitude higher J{sub c} and B{sub pin}, despite providing lower U{sub pin}. The MILD pinning centre morphology is discussed, and it is estimated that for present-day large grain high T{sub c} superconductors, a J{sub c} value of {approx}10{sup 6}Acm{sup -2} is obtainable at 77 K, even when crystal plane alignment and weak links are not improved. In addition, the pinned field is increased by over an order of magnitude. An experiment is proposed to confirm these calculations, directly compare MILD pinning to continuous columnar pinning, and determine the optimum MILD structure. Applications of MILD pinning are discussed.

  5. Digital in-line holographic microscopy applied to microfluidic studies

    Science.gov (United States)

    Garcia-Sucerquia, J.; Xu, W.; Jericho, S. K.; Jericho, M. H.; Kreuzer, H. J.

    2006-01-01

    Digital In-line Holographic Microscopy (DIHM) is a technique that provides depth and lateral resolution of the order of the wavelength throughout a volume of several cubic centimeters for visible light. This outstanding characteristic is reached by means of a simple optical setup and numerical reconstruction of the recorded holograms. It makes DIHM the right tool for applications in many microscopic studies. In this paper we study microfluidic phenomena by means of DIHM. To this end we seed a fluid with micron-size trackers (latex microspheres) and follow their displacement within an observation volume. We apply this technique to several situations such as the flow around a big sphere, flow through microchannels, bubbles in a fluid, bacterial motion in a diatom and the swimming behavior of paramecia and algae in water. By taking advantage in DIHM of the plane-to-plane reconstruction through a large depth of field, we generate 3D renderings of the paths followed by the trackers to produce a complete picture of the flow pattern, i.e. streamlines and velocity fields.

  6. Micro-Mechanical Temperature Sensors

    DEFF Research Database (Denmark)

    Larsen, Tom

    Temperature is the most frequently measured physical quantity in the world. The field of thermometry is therefore constantly evolving towards better temperature sensors and better temperature measurements. The aim of this Ph.D. project was to improve an existing type of micro-mechanical temperature...... sensor or to develop a new one. Two types of micro-mechanical temperature sensors have been studied: Bilayer cantilevers and string-like beam resonators. Both sensor types utilize thermally generated stress. Bilayer cantilevers are frequently used as temperature sensors at the micro-scale, and the goal....... The reduced sensitivity was due to initial bending of the cantilevers and poor adhesion between the two cantilever materials. No further attempts were made to improve the sensitivity of bilayer cantilevers. The concept of using string-like resonators as temperature sensors has, for the first time, been...

  7. Zeolite-dye micro lasers

    CERN Document Server

    Vietze, U; Laeri, F; Ihlein, G; Schüth, F; Limburg, B; Abraham, M

    1998-01-01

    We present a new class of micro lasers based on nanoporous molecular sieve host-guest systems. Organic dye guest molecules of 1-Ethyl-4-(4-(p-Dimethylaminophenyl)-1,3-butadienyl)-pyridinium Perchlorat were inserted into the 0.73-nm-wide channel pores of a zeolite AlPO$_4$-5 host. The zeolitic micro crystal compounds where hydrothermally synthesized according to a particular host-guest chemical process. The dye molecules are found not only to be aligned along the host channel axis, but to be oriented as well. Single mode laser emission at 687 nm was obtained from a whispering gallery mode oscillating in a 8-$\\mu$m-diameter monolithic micro resonator, in which the field is confined by total internal reflection at the natural hexagonal boundaries inside the zeolitic microcrystals.

  8. Dimensional micro and nano metrology

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; da Costa Carneiro, Kim; Haitjema, Han

    2006-01-01

    The need for dimensional micro and nano metrology is evident, and as critical dimensions are scaled down and geometrical complexity of objects is increased, the available technologies appear not sufficient. Major research and development efforts have to be undertaken in order to answer these chal......The need for dimensional micro and nano metrology is evident, and as critical dimensions are scaled down and geometrical complexity of objects is increased, the available technologies appear not sufficient. Major research and development efforts have to be undertaken in order to answer...... these challenges. The developments have to include new measuring principles and instrumentation, tolerancing rules and procedures as well as traceability and calibration. The current paper describes issues and challenges in dimensional micro and nano metrology by reviewing typical measurement tasks and available...

  9. MicroRNA and cancer

    DEFF Research Database (Denmark)

    Jansson, Martin D; Lund, Anders H

    2012-01-01

    biological phenomena and pathologies. The best characterized non-coding RNA family consists in humans of about 1400 microRNAs for which abundant evidence have demonstrated fundamental importance in normal development, differentiation, growth control and in human diseases such as cancer. In this review, we...... summarize the current knowledge and concepts concerning the involvement of microRNAs in cancer, which have emerged from the study of cell culture and animal model systems, including the regulation of key cancer-related pathways, such as cell cycle control and the DNA damage response. Importantly, microRNA......With the advent of next generation sequencing techniques a previously unknown world of non-coding RNA molecules have been discovered. Non-coding RNA transcripts likely outnumber the group of protein coding sequences and hold promise of many new discoveries and mechanistic explanations for essential...

  10. Development of Micro UAV Swarms

    Science.gov (United States)

    Bürkle, Axel; Leuchter, Sandro

    Some complex application scenarios for micro UAVs (Unmanned Aerial Vehicles) call for the formation of swarms of multiple drones. In this paper a platform for the creation of such swarms is presented. It consists of modified commercial quadrocopters and a self-made ground control station software architecture. Autonomy of individual drones is generated through a micro controller equipped video camera. Currently it is possible to fly basic maneuvers autonomously, such as take-off, fly to position, and landing. In the future the camera's image processing capabilities will be used to generate additional control information. Different co-operation strategies for teams of UAVs are currently evaluated with an agent based simulation tool. Finally complex application scenarios for multiple micro UAVs are presented.

  11. Novel Micro Fourier Transform Spectrometers

    Institute of Scientific and Technical Information of China (English)

    KONG Yan-mei; LIANG Jing-qiu; LIANG Zhong-zhu; WANG-Bo; ZHANG Jun

    2008-01-01

    The miniaturization of spectrometer opens a new application area with real-time and on-site measurements. The Fourier transform spectrometer(FTS) is much attractive considering its particular advantages among the approaches. This paper reviews the current status of micro FTS in worldwide and describes its developments; In addition, analyzed are the key problems in designing and fabricating FTS to be settled during the miniaturization. Finally, a novel model of micro FTS with no moving parts is proposed and analyzed, which may provide new concepts for the design of spectrometers.

  12. Phenotypic MicroRNA Microarrays

    OpenAIRE

    2013-01-01

    Microarray technology has become a very popular approach in cases where multiple experiments need to be conducted repeatedly or done with a variety of samples. In our lab, we are applying our high density spots microarray approach to microscopy visualization of the effects of transiently introduced siRNA or cDNA on cellular morphology or phenotype. In this publication, we are discussing the possibility of using this micro-scale high throughput process to study the role of microRNAs in the bio...

  13. Micro-machined calorimetric biosensors

    Science.gov (United States)

    Doktycz, Mitchel J.; Britton, Jr., Charles L.; Smith, Stephen F.; Oden, Patrick I.; Bryan, William L.; Moore, James A.; Thundat, Thomas G.; Warmack, Robert J.

    2002-01-01

    A method and apparatus are provided for detecting and monitoring micro-volumetric enthalpic changes caused by molecular reactions. Micro-machining techniques are used to create very small thermally isolated masses incorporating temperature-sensitive circuitry. The thermally isolated masses are provided with a molecular layer or coating, and the temperature-sensitive circuitry provides an indication when the molecules of the coating are involved in an enthalpic reaction. The thermally isolated masses may be provided singly or in arrays and, in the latter case, the molecular coatings may differ to provide qualitative and/or quantitative assays of a substance.

  14. Overview of MicroRNA Biology

    OpenAIRE

    2015-01-01

    In considering an overview of microRNA biology, it is useful to consider microRNAs as a part of cellular communication. At the simplest level, microRNAs act to decrease the expression of mRNAs that contain stretches of sequence complementary to the microRNA. This function can be likened to the function of endogenous or synthetic short interfering RNA (siRNA). However, microRNA function is more complicated and nuanced than this ‘on-off’ model would suggest. Further, many microRNA targets are t...

  15. Improvement of micro endmill geometry for micro hard milling application

    NARCIS (Netherlands)

    Li, P.; Oosterling, J.A.J.; Hoogstrate, A.M.; Langen, H.H.

    2008-01-01

    One of the applications of the micromilling technology is to machine micro features on moulds by direct machining of hardened tool steels. However at this moment, this process is not industrial applicable because of the encountered problems, such as the big tool deflection, severe tool wear, and

  16. Micro Gas Turbines (Micro turbines a gaz) (CD-ROM)

    Science.gov (United States)

    gasturbines , such as large heat fluxes, oil free bearings, high performance and compact heat exchangers, special combustion chamber designs and the use of...micro- gasturbines for propulsion of UAV and integration in fuel-cells are also presented. It is concluded that a lot of research is still required

  17. Improvement of micro endmill geometry for micro hard milling application

    NARCIS (Netherlands)

    Li, P.; Oosterling, J.A.J.; Hoogstrate, A.M.; Langen, H.H.

    2008-01-01

    One of the applications of the micromilling technology is to machine micro features on moulds by direct machining of hardened tool steels. However at this moment, this process is not industrial applicable because of the encountered problems, such as the big tool deflection, severe tool wear, and pre

  18. The collection of MicroED data for macromolecular crystallography.

    Science.gov (United States)

    Shi, Dan; Nannenga, Brent L; de la Cruz, M Jason; Liu, Jinyang; Sawtelle, Steven; Calero, Guillermo; Reyes, Francis E; Hattne, Johan; Gonen, Tamir

    2016-05-01

    The formation of large, well-ordered crystals for crystallographic experiments remains a crucial bottleneck to the structural understanding of many important biological systems. To help alleviate this problem in crystallography, we have developed the MicroED method for the collection of electron diffraction data from 3D microcrystals and nanocrystals of radiation-sensitive biological material. In this approach, liquid solutions containing protein microcrystals are deposited on carbon-coated electron microscopy grids and are vitrified by plunging them into liquid ethane. MicroED data are collected for each selected crystal using cryo-electron microscopy, in which the crystal is diffracted using very few electrons as the stage is continuously rotated. This protocol gives advice on how to identify microcrystals by light microscopy or by negative-stain electron microscopy in samples obtained from standard protein crystallization experiments. The protocol also includes information about custom-designed equipment for controlling crystal rotation and software for recording experimental parameters in diffraction image metadata. Identifying microcrystals, preparing samples and setting up the microscope for diffraction data collection take approximately half an hour for each step. Screening microcrystals for quality diffraction takes roughly an hour, and the collection of a single data set is ∼10 min in duration. Complete data sets and resulting high-resolution structures can be obtained from a single crystal or by merging data from multiple crystals.

  19. The Prediction of Fatigue Life Based on Four Point Bending Test

    NARCIS (Netherlands)

    Pramesti, F.P.; Molenaar, A.A.A.; Van de Ven, M.F.C.

    2013-01-01

    To be able to devise optimum strategies for maintenance and rehabilitation, it is essential to formulate an accurate prediction of pavement life and its maintenance needs. One of the pavement life prediction methods is based on the pavement's capability to sustain fatigue. If it were possible to hav

  20. Long-term evaluation of the performance of four point-of-use water filters.

    Science.gov (United States)

    Pérez-Vidal, Andrea; Diaz-Gómez, Jaime; Castellanos-Rozo, Jose; Usaquen-Perilla, Olga Lucía

    2016-07-01

    Despite technological advances water supply quality and poor access to safe water remain a major problem in developing countries, especially in rural areas. Point-of-use (POU) water treatment has been shown to be a viable option to produce safe drinking water quality. The aim of this study was to evaluate, under laboratory conditions over 14 months, the performance of four household filtration systems: membrane filter (MF), one-candle ceramic filter (1CCF), two-candle ceramic filter (2CCF) and pot ceramic filter (PCF). The evaluation was made using spiked water having the required concentrations of turbidity, Escherichia coli and Total Dissolved Solids (TDS). The results show that all systems have high removal efficiencies for turbidity (98-99%), and E. coli 4-5 Log Reduction Value (LRV). The poorest efficiency was for TDS (9-18%). The MF and the CCF displayed no significant difference in efficiencies for these parameters. The PCF had less significant differences for turbidity removal than the other systems. The average filtration rate for all systems decreased during the operation time. The CPF showed the major potential to be used in rural communities mainly for its low operational level and maintenance requirements as well as its local craftsmanship. It was observed that the efficiency of the systems is highly sensitive to cleaning and maintenance activities and therefore, the system sustainability will depend considerably on the training and education of the potential users.

  1. [Four points on the sociodemographic problematic of the city of Puebla].

    Science.gov (United States)

    Sanchez Avina, J G

    1991-12-01

    The city of Puebla has become an important pole of regional economic growth in Mexico as a result of sizeable investments in industry and services over the past 3 decades and because of its location on the route from the gulf of Mexico to Mexico City. The growth of the city and surrounding municipios has led to considerable expansion of the urbanized area. The city today contains 26% of the state population in less than 2% of its territory. The population density of 2012 per sq km is far above the state average of 121. Puebla's growth has resulted form in-migration from nearby settlements and of rural dwellers from farther afield hoping to escape rural hardships and from absorption of small surrounding settlements by the city, as well as from natural increase. The city suffers from a deficiency of equipment and services needed to satisfy the needs of its rapidly growing population. 4 serious problems in the city related to its rapid growth are the spread of marginal housing, impoverishment of the architectural landscape of the city. Disarticulation of the road system and anarchy in the public transportation system, and dangerous contamination of water. The majority of recent migrants to Puebla have not been rapidly and adequately absorbed into the urban population. Underemployment and marginalization have awaited many rural migrants, who have sought to establish themselves in impoverished zones of the city. Breakdowns in family relationships and other forms of social pathology are common in these zones. The uncontrolled population increase and urbanization of Puebla have transformed the city into a propitious area for social conflict.

  2. Four-point probe electrical resistivity scanning system for large area conductivity and activation energy mapping.

    Science.gov (United States)

    Shimanovich, Klimentiy; Bouhadana, Yaniv; Keller, David A; Rühle, Sven; Anderson, Assaf Y; Zaban, Arie

    2014-05-01

    The electrical properties of metal oxides play a crucial role in the development of new photovoltaic (PV) systems. Here we demonstrate a general approach for the determination and analysis of these properties in thin films of new metal oxide based PV materials. A high throughput electrical scanning system, which facilitates temperature dependent measurements at different atmospheres for highly resistive samples, was designed and constructed. The instrument is capable of determining conductivity and activation energy values for relatively large sample areas, of about 72 × 72 mm(2), with the implementation of geometrical correction factors. The efficiency of our scanning system was tested using two different samples of CuO and commercially available Fluorine doped tin oxide coated glass substrates. Our high throughput tool was able to identify the electrical properties of both resistive metal oxide thin film samples with high precision and accuracy. The scanning system enabled us to gain insight into transport mechanisms with novel compositions and to use those insights to make smart choices when choosing materials for our multilayer thin film all oxide photovoltaic cells.

  3. Oxidation of clean silicon surfaces studied by four-point probe surface conductance measurements

    DEFF Research Database (Denmark)

    Petersen, Christian Leth; Grey, Francois; Aono, M.

    1997-01-01

    We have investigated how the conductance of Si(100)-(2 x 1) and Si(111)-(7 x 7) surfaces change during exposure to molecular oxygen. A monotonic decrease in conductance is seen as the (100) surfaces oxidizes. In contract to a prior study, we propose that this change is caused by a decrease in sur...

  4. Four-point probe resistance measurements using PtIr-coated carbon nanotube tips.

    Science.gov (United States)

    Yoshimoto, Shinya; Murata, Yuya; Kubo, Keisuke; Tomita, Kazuhiro; Motoyoshi, Kenji; Kimura, Takehiko; Okino, Hiroyuki; Hobara, Rei; Matsuda, Iwao; Honda, Shin-Ichi; Katayama, Mitsuhiro; Hasegawa, Shuji

    2007-04-01

    We performed four-terminal conductivity measurements on a CoSi2 nanowire (NW) at room temperature by using PtIr-coated carbon nanotube (CNT) tips in a four-tip scanning tunneling microscope. The physical stability and high aspect ratio of the CNT tips made it possible to reduce the probe spacing down to ca. 30 nm. The probe-spacing dependence of resistance showed diffusive transport even at 30 nm and no current leakage to the Si substrate.

  5. Four point probe structures with buried electrodes for the electrical characterization of ultrathin conducting films

    NARCIS (Netherlands)

    Groenland, A.W.; Wolters, R.A.M.; Kovalgin, A.Y.; Schmitz, J.

    2009-01-01

    Test structures for the electrical characterization of ultrathin conductive (ALD) films are presented based on buried electrodes on which the ultrathin film is deposited. This work includes test structure design and fabrication, and the electrical characterization of ALD TiN films down to 4 nm. It i

  6. Non-Perturbative Four-Point Scattering from First-Quantized Relativistic JWKB

    CERN Document Server

    Irizarry-Gelpí, M E

    2016-01-01

    We apply the quantum mechanical (first-quantized) JWKB approximation to a two-body path integral describing the near-forward scattering of two relativistic, heavy, non-identical, scalar particles in $D$ spacetime dimensions. In contrast to the loop expansion, in $D = 4$ this gives a strong-coupling expansion, and in $D = 3$ a non-perturbative weak-coupling expansion. When the interaction is mediated by massless quanta with spin $N$, we obtain explicit, relativistic results for the scattering amplitude when $N = 0$, $1$ and $2$. In $D = 4$ we find a Regge trajectory function that agrees with the usual quantum mechanical spectrum. We also find an exponentiated infrared divergence that becomes a pure phase factor when the Mandelstam invariants $s$ and $t$ are inside of the physical scattering region. In $D = 3$ we find a singularity whose position along the $s$ axis is dependent on $t$. When the interaction is mediated by a heavy scalar with mass $M$, in $D = 3$ we find an all-order scattering amplitude where th...

  7. Foliations on the moduli space of rank two connections on the projective line minus four points

    CERN Document Server

    Loray, Frank; Simpson, Carlos T

    2010-01-01

    We look at natural foliations on the Painlev\\'e VI moduli space of regular connections of rank 2 on $\\pp ^1 -\\{t_1,t_2,t_3,t_4\\}$. These foliations are fibrations, and are interpreted in terms of the nonabelian Hodge filtration, giving a proof of the nonabelian Hodge foliation conjecture in this case. Two basic kinds of fibrations arise: from apparent singularities, and from quasiparabolic bundles. We show that these are transverse. Okamoto's additional symmetry, which may be seen as Katz's middle convolution, exchanges the quasiparabolic and apparent-singularity foliations.

  8. Four point measurements of electrons using PEACE in the high-altitude cusp

    Directory of Open Access Journals (Sweden)

    M. G. G. T. Taylor

    Full Text Available We present examples of electron measurements from the PEACE instruments on the Cluster spacecraft in the high-latitude, high-altitude region of the Earth’s magnetosphere. Using electron density and energy spectra measurements, we examine two cases where the orbit of the Cluster tetrahedron is outbound over the northern hemisphere, in the afternoon sector approaching the magnetopause. Data from the magnetometer is also used to pinpoint the position of the spacecraft with respect to magnetospheric boundaries. This preliminary work specifically highlights the benefit of the multipoint measurement capability of the Cluster mission. In the first case, we observe a small-scale spatial structure within the magnetopause boundary layer. The Cluster spacecraft initially straddle a boundary, characterised by a discontinuous change in the plasma population, with a pair of spacecraft on either side. This is followed by a complete crossing of the boundary by all four spacecraft. In the second case, Cluster encounters an isolated region of higher energy electrons within the cusp. The characteristics of this region are consistent with a trapped boundary layer plasma sheet population on closed magnetospheric field lines. However, a boundary motion study indicates that this region convects past Cluster, a characteristic more consistent with open field lines. An interpretation of this event in terms of the motion of the cusp boundary region is presented.

    Key words. Magnetospheric physics (magnetopause, cusp and boundary layers; solar wind-magnetosphere interactions

  9. Accuracy of bubble velocity measurement with a four-point optical fibre probe

    NARCIS (Netherlands)

    Bai, Wei; Deen, Niels G.; Mudde, Robert F.; Kuipers, J.A.M.

    2008-01-01

    For the operation of high void fraction bubbly flows in bubble columns, insight in primary parameters such as bubble size, shape and velocity as well as gas volume fraction is essential. At high gas volume fractions the flow system becomes opaque, ruling out non-intrusive optical techniques. As an a

  10. Micro RNAs in animal development.

    NARCIS (Netherlands)

    Plasterk, R.H.A.

    2006-01-01

    Micro RNAs (miRNAs) are approximately 22 nucleotide single-stranded noncoding RNA molecules that bind to target messenger RNAs (mRNAs) and silence their expression. This Essay explores the importance of miRNAs in animal development and their possible roles in disease and evolution.

  11. Micro-Based Genlocking Systems.

    Science.gov (United States)

    Hurly, Paul

    1986-01-01

    Presents a selective survey of micro-based genlocking systems currently on the market including those systems with open and closed architecture; examines the number and diversity of uses for this hybrid medium, which synchronizes video signals with computer-generated text and graphics; and discusses the role of cause and effect in innovation.

  12. Micro-machined resonator oscillator

    Science.gov (United States)

    Koehler, Dale R.; Sniegowski, Jeffry J.; Bivens, Hugh M.; Wessendorf, Kurt O.

    1994-01-01

    A micro-miniature resonator-oscillator is disclosed. Due to the miniaturization of the resonator-oscillator, oscillation frequencies of one MHz and higher are utilized. A thickness-mode quartz resonator housed in a micro-machined silicon package and operated as a "telemetered sensor beacon" that is, a digital, self-powered, remote, parameter measuring-transmitter in the FM-band. The resonator design uses trapped energy principles and temperature dependence methodology through crystal orientation control, with operation in the 20-100 MHz range. High volume batch-processing manufacturing is utilized, with package and resonator assembly at the wafer level. Unique design features include squeeze-film damping for robust vibration and shock performance, capacitive coupling through micro-machined diaphragms allowing resonator excitation at the package exterior, circuit integration and extremely small (0.1 in. square) dimensioning. A family of micro-miniature sensor beacons is also disclosed with widespread applications as bio-medical sensors, vehicle status monitors and high-volume animal identification and health sensors. The sensor family allows measurement of temperatures, chemicals, acceleration and pressure. A microphone and clock realization is also available.

  13. Micro RNAs in animal development.

    NARCIS (Netherlands)

    Plasterk, R.H.A.

    2006-01-01

    Micro RNAs (miRNAs) are approximately 22 nucleotide single-stranded noncoding RNA molecules that bind to target messenger RNAs (mRNAs) and silence their expression. This Essay explores the importance of miRNAs in animal development and their possible roles in disease and evolution.

  14. Micro Evolutionary Processes and Adaptation

    Institute of Scientific and Technical Information of China (English)

    SHADMANOV; R; K; RUBAN; I; N; VOROPAEVA; N; L; SHADMANOVA; A; R

    2008-01-01

    It would be well to note that in the absence of clear data about the formation of adaptation systems,or mechanisms of their occurrence,all that is recognized is the realization of the micro evolutionary processes.There is no well-defined connection between information exchange and formation of

  15. Micro-Electro-Mechanical Systems

    NARCIS (Netherlands)

    Sarro, P.M.

    2008-01-01

    Micro-electro-mechanical systems (MEMS) or Microsystems technology (MST) is a fascinating and exciting field which significantly contributes to build a bridge between science and society. Physical properties and material characteristics are translated into structures and devices that can have a larg

  16. Micro-Electro-Mechanical Systems

    NARCIS (Netherlands)

    Sarro, P.M.

    2008-01-01

    Micro-electro-mechanical systems (MEMS) or Microsystems technology (MST) is a fascinating and exciting field which significantly contributes to build a bridge between science and society. Physical properties and material characteristics are translated into structures and devices that can have a

  17. Micro-Encapsulation of Probiotics

    Science.gov (United States)

    Meiners, Jean-Antoine

    Micro-encapsulation is defined as the technology for packaging with the help of protective membranes particles of finely ground solids, droplets of liquids or gaseous materials in small capsules that release their contents at controlled rates over prolonged periods of time under the influences of specific conditions (Boh, 2007). The material encapsulating the core is referred to as coating or shell.

  18. Equivalent Simplification Method of Micro-Grid

    OpenAIRE

    Cai Changchun; Cao Xiangqin

    2013-01-01

    The paper concentrates on the equivalent simplification method for the micro-grid system connection into distributed network. The equivalent simplification method proposed for interaction study between micro-grid and distributed network. Micro-grid network, composite load, gas turbine synchronous generation, wind generation are equivalent simplification and parallel connect into the point of common coupling. A micro-grid system is built and three phase and single phase grounded faults are per...

  19. IEMDC IN-LINE ELECTRIC MOTOR DRIVEN COMPRESSOR

    Energy Technology Data Exchange (ETDEWEB)

    Michael J. Crowley; Prem N. Bansal

    2004-10-01

    This report contains the final project summary and deliverables required by the award for the development of an In-line Electric Motor Driven Compressor (IEMDC). Extensive work was undertaken during the course of the project to develop the motor and the compressor section of the IEMDC unit. Multiple design iterations were performed to design an electric motor for operation in a natural gas environment and to successfully integrate the motor with a compressor. During the project execution, many challenges were successfully overcome in order to achieve the project goals and to maintain the system design integrity. Some of the challenges included limiting the magnitude of the compressor aerodynamic loading for appropriate sizing of the magnetic bearings, achieving a compact motor rotor size to meet the rotor dynamic requirements of API standards, devising a motor cooling scheme using high pressure natural gas, minimizing the impact of cooling on system efficiency, and balancing the system thrust loads for the magnetic thrust bearing. Design methods that were used on the project included validated state-of-the-art techniques such as finite element analysis and computational fluid dynamics along with the combined expertise of both Curtiss-Wright Electro-Mechanical Corporation and Dresser-Rand Company. One of the most significant areas of work undertaken on the project was the development of the unit configuration for the system. Determining the configuration of the unit was a significant step in achieving integration of the electric motor into a totally enclosed compression system. Product review of the IEMDC unit configuration was performed during the course of the development process; this led to an alternate design configuration. The alternate configuration is a modular design with the electric motor and compressor section each being primarily contained in its own pressure containing case. This new concept resolved the previous conflict between the aerodynamic flow

  20. Investigation of air entrapment and weld line defects in micro injection moulded thermoplastic elastomer micro rings

    DEFF Research Database (Denmark)

    Hasnaes, F.B.; Tosello, Guido; Calaon, Matteo;

    2015-01-01

    The micro injection moulding (μIM) process for the production of micro rings in thermoplastic elastomers (TPE) was investigated and optimized. The objective was to minimize the formation of air entrapments and the depth of micro weld line created on the surface of the TPE micro moulded rings...

  1. Micro tooling technologies for polymer micro replication: direct, indirect and hybrid process chains

    DEFF Research Database (Denmark)

    Tosello, Guido; Hansen, Hans Nørgaard

    2009-01-01

    and performance of the corresponding micro mould. Traditional methods of micro tooling, such as various machining processes (e.g. micro milling, micro electrical discharge machining) have already reached their limitations with decreasing dimensions of mould inserts and cavities. To this respect, tooling process...

  2. Spontaneous Calcium Changes in Micro Neuronal Networks

    Science.gov (United States)

    Saito, Aki; Moriguchi, Hiroyuki; Iwabuchi, Shin; Goto, Miho; Takayama, Yuzo; Kotani, Kiyoshi; Jimbo, Yasuhiko

    We have developed a practical experimental method to mass-produce and maintain a variation of minimal neuronal networks (“micro neuronal networks”) consisted of a single to several neurons in culture using spray-patterning technique. In this paper, we could maintain the micro-cultures for one month or more by adding conditioned medium and carried out optical recording of spontaneous activity in micro neuronal networks and considered the interactions between them. To determine the interactions between micro neuronal networks, fluorescence changes in several small networks were simultaneously measured using calcium indicator dye fluo-4 AM, and time-series analysis was carried out using surrogate arrangements. By using the spray-patterning method, a large number of cell-adhesive micro regions were formed. Neurons extended neurites along the edge of the cell-adhesive micro regions and form micro neuronal networks. In part of micro regions, some neurite was protruded from the region, and thus micro neuronal networks were connected with synapses. In these networks, a single neuron-induced network activity was observed. On the other hand, even in morphologically non-connected micro neuronal networks, synchronous oscillations between micro neuronal networks were observed. Our micro-patterning methods and results provide the possibility that synchronous activity is occurred between morphologically non-connected neuronal networks. This suggest that the humoral factor is also a important component for network-wide dynamics.

  3. A thermally self-sustained micro-power plant with integrated micro-solid oxide fuel cells, micro-reformer and functional micro-fluidic carrier

    NARCIS (Netherlands)

    Scherrer, B.; Evans, A.; Santis-Alvarez, A. J.; Jiang, B.; Martynczuk, J.; Galinski, H.; Nabavi, M.; Prestat, M.; Tölke, R.; Bieberle, A.; Poulikakos, D.; Muralt, P.; Niedermann, P.; Dommann, A.; Maeder, T.; Heeb, P.; Straessle, V.; Muller, C.; Gauckler, L. J.

    2014-01-01

    Low temperature micro-solid oxide fuel cell (micro-SOFC) systems are an attractive alternative power source for small-size portable electronic devices due to their high energy efficiency and density. Here, we report on a thermally self-sustainable reformer micro-SOFC assembly. The device consists of

  4. Development and design of micro products

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard

    2004-01-01

    Innovation within the field of micro and nano technology is characterized by cross-disciplinary skills The IT-sector driven development of materials/technologies related to semiconductors and silicon The more traditional materials polymers, metals, ceramics: well suited for mass production...... but not widespread in micro products today New possibilities with expensive materials in micro products....

  5. Micro-Doppler Analysis of Small UAVs

    NARCIS (Netherlands)

    Wit, J.J.M. de; Harmanny, R.I.A.; Prémel Cabic, G.

    2012-01-01

    Coherent radar measures micro-Doppler properties of moving objects. The micro-Doppler signature depends on parts of an object moving and rotating in addition to the main body motion (e.g. rotor blades) and is therefore characteristic for the type of object. In this study, the micro-Doppler signature

  6. Micro-Doppler Analysis of Small UAVs

    NARCIS (Netherlands)

    Wit, J.J.M. de; Harmanny, R.I.A.; Prémel Cabic, G.

    2012-01-01

    Coherent radar measures micro-Doppler properties of moving objects. The micro-Doppler signature depends on parts of an object moving and rotating in addition to the main body motion (e.g. rotor blades) and is therefore characteristic for the type of object. In this study, the micro-Doppler signature

  7. A thermally self-sustained micro-power plant with integrated micro-solid oxide fuel cells, micro-reformer and functional micro-fluidic carrier

    NARCIS (Netherlands)

    Scherrer, B.; Evans, A.; Santis-Alvarez, A. J.; Jiang, B.; Martynczuk, J.; Galinski, H.; Nabavi, M.; Prestat, M.; Tölke, R.; Bieberle, A.; Poulikakos, D.; Muralt, P.; Niedermann, P.; Dommann, A.; Maeder, T.; Heeb, P.; Straessle, V.; Muller, C.; Gauckler, L. J.

    2014-01-01

    Low temperature micro-solid oxide fuel cell (micro-SOFC) systems are an attractive alternative power source for small-size portable electronic devices due to their high energy efficiency and density. Here, we report on a thermally self-sustainable reformer micro-SOFC assembly. The device consists of

  8. Fabrication of micro DOE using micro tools shaped with focused ion beam.

    Science.gov (United States)

    Xu, Z W; Fang, F Z; Zhang, S J; Zhang, X D; Hu, X T; Fu, Y Q; Li, L

    2010-04-12

    A novel method is proposed to fabricate micro Diffractive Optical Elements (DOE) using micro cutting tools shaped with focused ion beam (FIB) milling. Micro tools with nanometric cutting edges and complicated shapes are fabricated by controlling the tool facet's orientation relative to the FIB. The tool edge radius of less than 30 nm is achieved for the nano removal of the work materials. Semi-circular micro tools and DOE-shaped micro tools are developed to fabricate micro-DOE and sinusoidal modulation templates. Experiments show that the proposed method can be a high efficient way in fabricating micro-DOE with nanoscale surface finishes.

  9. Micro system comprising 96 micro valves on a titer plate

    Science.gov (United States)

    Krabbe, S.; Flitsch, D.; Büchs, J.; Schomburg, W. K.

    2016-10-01

    A system of 96 micro valves has been developed and mounted on top of a 48-well micro titer plate providing two valves for each well controlling its air inlet and outlet. Testing of the valve system showed that all valves are working and are opened and closed reliably. A pneumatic system is switching inlet and outlet valves independently of each other. The geometry of the feed channels ensures an equal air flow through all wells, when the valves are open. Between the micro valves, one optical fibre was inserted through the lid of each well allowing measuring the oxygen partial pressure in the enclosed air volume by fluorescence sensor spots. Escherichia coli bacteria were grown inside the wells and their metabolism was observed by the oxygen partial pressure change due to respiration. In all 48 wells, the same oxygen transfer rate was observed within an averaged standard deviation of 1 mmol/L/h. The oxygen transfer rate differences compared to a macroscopic standard shake flask system were overall compatible within their uncertainties.

  10. The MicroObservatory Net

    Science.gov (United States)

    Brecher, K.; Sadler, P.

    1994-12-01

    A group of scientists, engineers and educators based at the Harvard-Smithsonian Center for Astrophysics (CfA) has developed a prototype of a small, inexpensive and fully integrated automated astronomical telescope and image processing system. The project team is now building five second generation instruments. The MicroObservatory has been designed to be used for classroom instruction by teachers as well as for original scientific research projects by students. Probably in no other area of frontier science is it possible for a broad spectrum of students (not just the gifted) to have access to state-of-the-art technologies that would allow for original research. The MicroObservatory combines the imaging power of a cooled CCD, with a self contained and weatherized reflecting optical telescope and mount. A microcomputer points the telescope and processes the captured images. The MicroObservatory has also been designed to be used as a valuable new capture and display device for real time astronomical imaging in planetariums and science museums. When the new instruments are completed in the next few months, they will be tried with high school students and teachers, as well as with museum groups. We are now planning to make the MicroObservatories available to students, teachers and other individual users over the Internet. We plan to allow the telescope to be controlled in real time or in batch mode, from a Macintosh or PC compatible computer. In the real-time mode, we hope to give individual access to all of the telescope control functions without the need for an "on-site" operator. Users would sign up for a specific period of time. In the batch mode, users would submit jobs for the telescope. After the MicroObservatory completed a specific job, the images would be e-mailed back to the user. At present, we are interested in gaining answers to the following questions: (1) What are the best approaches to scheduling real-time observations? (2) What criteria should be used

  11. Isolation of microRNA targets using biotinylated synthetic microRNAs

    DEFF Research Database (Denmark)

    Ørom, Ulf Andersson; Lund, Anders H

    2007-01-01

    MicroRNAs are small regulatory RNAs found in multicellular organisms where they post-transcriptionally regulate gene expression. In animals, microRNAs bind mRNAs via incomplete base pairings making the identification of microRNA targets inherently difficult. Here, we present a detailed method...... for experimental identification of microRNA targets based on affinity purification of tagged microRNAs associated with their targets. Udgivelsesdato: 2007-Oct...

  12. Integration of micro milling highspeed spindle on a microEDM-milling machine set-up

    DEFF Research Database (Denmark)

    De Grave, Arnaud; Hansen, Hans Nørgaard; Andolfatto, Loic

    2009-01-01

    In order to cope with repositioning errors and to combine the fast removal rate of micro milling with the precision and small feature size achievable with micro EDM milling, a hybrid micro-milling and micro-EDM milling centre was built and tested. The aim was to build an affordable set-up, easy...... by micro milling. Examples of test parts are shown and used as an experimental validation....

  13. 肿瘤相关巨噬细胞microRNA表达谱及生物信息学分析%Profile of microRNA expression in tumor associated macrophage and bioinformatics analysis

    Institute of Scientific and Technical Information of China (English)

    雷宇; 刘彦信; 葛晔华; 史娟; 郑德先

    2012-01-01

    Objective To investigate the profile of microRNA expression in tumor associated macrophage (TAM). Methods An xenograft mouse model was established with mouse breast cancer cell line 4T1. TAM were isolated from the tumor tissue. The microRNA expression profile was detected by using a microRNA chip assay. The result of chip assay was validated by real-time PCR and analyzed by bioinformatics. The peritoneal macrophage was used as control. Results There were significant changes in 59 microRNAs' expression in TAM as compared with the negative control. Among these microRNAs, 23 microRNAs' expression was up regulated and 36 were down regulated. Real-time PCR verified the expression of miR-146a, miR-222, miR-31 and miR-877, these results are in line with chip experiment. These microRNAs participate in the regulation of various signaling pathways. Conclusions Profile of microRNA expression and bioinformatics analysis suggeste microRNA plays an important role in the regulation of TAM differentiation.%目的 研究肿瘤相关巨噬细胞( TAM) microRNA的表达谱.方法 建立小鼠乳腺癌细胞系4T1移植瘤模型,从移植瘤组织中分离TAM,用基因芯片检测microRNA表达谱,实时荧光定量PCR( real-time PCR)验证芯片结果并进行生物信息学分析,以小鼠腹腔巨噬细胞(PEC)为阴性对照.结果 与阴性对照细胞相比,TAM中有59个microRNAs表达量出现显著变化,其中23个microRNAs表达上调,有36个microRNAs表达下调;实时荧光定量PCR对miR-146a、miR-222、miR-31和miR-877的表达进行了验证,其结果与基因芯片检测结果一致;这些microRNAs参与了多个信号通路的调控.结论 microRNA表达谱及生物信息学分析表明microRNA在TAM分化过程的调控中有重要作用.

  14. Emotional context influences micro-expression recognition.

    Directory of Open Access Journals (Sweden)

    Ming Zhang

    Full Text Available Micro-expressions are often embedded in a flow of expressions including both neutral and other facial expressions. However, it remains unclear whether the types of facial expressions appearing before and after the micro-expression, i.e., the emotional context, influence micro-expression recognition. To address this question, the present study used a modified METT (Micro-Expression Training Tool paradigm that required participants to recognize the target micro-expressions presented briefly between two identical emotional faces. The results of Experiments 1 and 2 showed that negative context impaired the recognition of micro-expressions regardless of the duration of the target micro-expression. Stimulus-difference between the context and target micro-expression was accounted for in Experiment 3. Results showed that a context effect on micro-expression recognition persists even when the stimulus similarity between the context and target micro-expressions was controlled. Therefore, our results not only provided evidence for the context effect on micro-expression recognition but also suggested that the context effect might result from both the stimulus and valence differences.

  15. Introduction to micro- and nanooptics

    CERN Document Server

    Jahns, Jürgen

    2012-01-01

    This first textbook on both micro- and nanooptics introduces readers to the technological development, physical background and key areas.The opening chapters on the physics of light are complemented by chapters on refractive and diffractive optical elements. The internationally renowned authors present different methods of lithographic and nonlithographic fabrication of microoptics and introduce the characterization and testing of microoptics.The second part of the book is dedicated to optical microsystems and MEMS, optical waveguide structures and optical nanostructures, including pho

  16. Combinatorial microRNA target predictions

    DEFF Research Database (Denmark)

    Krek, Azra; Grün, Dominic; Poy, Matthew N.

    2005-01-01

    MicroRNAs are small noncoding RNAs that recognize and bind to partially complementary sites in the 3' untranslated regions of target genes in animals and, by unknown mechanisms, regulate protein production of the target transcript1, 2, 3. Different combinations of microRNAs are expressed...... in different cell types and may coordinately regulate cell-specific target genes. Here, we present PicTar, a computational method for identifying common targets of microRNAs. Statistical tests using genome-wide alignments of eight vertebrate genomes, PicTar's ability to specifically recover published micro......RNA targets, and experimental validation of seven predicted targets suggest that PicTar has an excellent success rate in predicting targets for single microRNAs and for combinations of microRNAs. We find that vertebrate microRNAs target, on average, roughly 200 transcripts each. Furthermore, our results...

  17. Micro-Kelvin cold molecules.

    Energy Technology Data Exchange (ETDEWEB)

    Strecker, Kevin E.; Chandler, David W.

    2009-10-01

    We have developed a novel experimental technique for direct production of cold molecules using a combination of techniques from atomic optical and molecular physics and physical chemistry. The ability to produce samples of cold molecules has application in a broad spectrum of technical fields high-resolution spectroscopy, remote sensing, quantum computing, materials simulation, and understanding fundamental chemical dynamics. Researchers around the world are currently exploring many techniques for producing samples of cold molecules, but to-date these attempts have offered only limited success achieving milli-Kelvin temperatures with low densities. This Laboratory Directed Research and Development project is to develops a new experimental technique for producing micro-Kelvin temperature molecules via collisions with laser cooled samples of trapped atoms. The technique relies on near mass degenerate collisions between the molecule of interest and a laser cooled (micro-Kelvin) atom. A subset of collisions will transfer all (nearly all) of the kinetic energy from the 'hot' molecule, cooling the molecule at the expense of heating the atom. Further collisions with the remaining laser cooled atoms will thermally equilibrate the molecules to the micro-Kelvin temperature of the laser-cooled atoms.

  18. Estimating the potential for in-line hydropower in the Himalayas: from global remote sensing data to local flow duration curves

    Science.gov (United States)

    Muller, M. F.; Thompson, S. E.; Hermanowicz, S. W.; Jordan, F.

    2012-12-01

    Adopting multi-use systems in rural water infrastructure is a promising strategy to improve the sustainability of water utilities. For example, in-line hydropower - an infrastructure concept that combines water supply and micro-hydropower - has been successfully implemented in Switzerland for a century. Net profit from electricity is used to cross-subsidize water supply, improving the financial sustainability of water utilities. The concept is transferable to mountainous regions of developing countries, where it promises to alleviate the financial constraints that currently inhibit water supply development. Yet field attempts are missing to evaluate the success of trial in-line hydropower implementations, and a dearth of distributed hydrological and meteorological data complicates evaluations of the potential for future development. In this context, remote sensing offers a powerful technique to overcome data-scarcity issues in developing nations to facilitate the development of appropriate water supply technology. To utilize remotely sensed data for infrastructure planning, however, downscaling and regionalization challenges have to be addressed, especially in the mountainous regions where in-line hydropower would be applicable. Nepal offers an excellent test-bed to explore the potential for incorporating remote-sensing data into water resources planning. Here we present initial downscaling of TRMM daily precipitation data to a 5 x 5 km grid, including bias correction and explicit consideration of elevation effects. Several complementary approaches, including fractal downscaling, statistical downscaling and CDF-matching bias correction are evaluated through a cross-validation process. The results are used to drive different regionalization approaches for flow duration curves of Nepalese rivers. Finally, the relevance of in-line hydropower in rural mountainous communities is briefly discussed, based on feasibility assessments recently conducted in Central Nepal.

  19. On the Job Training in Line Heating in Astilleros Espanoles Shipyards, A Profitable Experience

    Science.gov (United States)

    1993-11-01

    1993 Ship Production Symposium Paper No. 5: On the Job Training in Line Heating in Astilleros Espanoles Shipyards, A Profitable Experience U.S...National Shipbuilding Research Program, 1993 Ship Production Symposium Paper No. 5: On the Job Training in Line Heating in Astilleros Espanoles Shipyards

  20. Application of Flexible Micro Temperature Sensor in Oxidative Steam Reforming by a Methanol Micro Reformer

    Directory of Open Access Journals (Sweden)

    Yi-Man Lo

    2011-02-01

    Full Text Available Advances in fuel cell applications reflect the ability of reformers to produce hydrogen. This work presents a flexible micro temperature sensor that is fabricated based on micro-electro-mechanical systems (MEMS technology and integrated into a flat micro methanol reformer to observe the conditions inside that reformer. The micro temperature sensor has higher accuracy and sensitivity than a conventionally adopted thermocouple. Despite various micro temperature sensor applications, integrated micro reformers are still relatively new. This work proposes a novel method for integrating micro methanol reformers and micro temperature sensors, subsequently increasing the methanol conversion rate and the hydrogen production rate by varying the fuel supply rate and the water/methanol ratio. Importantly, the proposed micro temperature sensor adequately controls the interior temperature during oxidative steam reforming of methanol (OSRM, with the relevant parameters optimized as well.

  1. Sensitivity Jump of Micro Accelerometer Induced by Micro-fabrication Defects of Micro Folded Beams

    Directory of Open Access Journals (Sweden)

    Zhou Wu

    2016-08-01

    Full Text Available The abnormal phenomenon occurring in sensor calibration is an obstacle to product development but a useful guideline to product improvement. The sensitivity jump of micro accelerometers in the calibrating process is recognized as an important abnormal behavior and investigated in this paper. The characteristics of jumping output in the centrifuge test are theoretically and experimentally analyzed and their underlying mechanism is found to be related to the varied stiffness of supporting beam induced by the convex defect on it. The convex defect is normally formed by the lithography deviation and/or etching error and can result in a jumping stiffness of folded microbeams and further influence the sensitivity when a part of the bending beams is stopped from moving by two surfaces contacting. The jumping level depends on the location of convex and has nothing to do with the contacting properties of beam and defects. Then the location of defect is predicted by theoretical model and simulation and verified by the observation of micro structures under microscopy. The results indicate that the tested micro accelerometer has its defect on the beam with a distance of about 290μm from the border of proof mass block.

  2. microRNA Decay: Refining microRNA Regulatory Activity.

    Science.gov (United States)

    Pepin, Genevieve; Gantier, Michael P

    2016-01-01

    MicroRNAs (miRNAs) are short 19-25 nucleotide RNA molecules that impact on most biological processes by regulating the efficiency of messenger RNA (mRNA) translation. To date, most research activities have been focused on the control of miRNA expression and its functional consequences. Nonetheless, much remains unknown about the mechanisms affecting the level of specific miRNAs in the cell, a critical feature impacting their regulatory activity. This review focuses on the factors that regulate the abundance of miRNAs, including synthesis, post-transcriptional modifications, nucleases, target binding, and secretion.

  3. Experimental investigation of energy localization in line-defect resonator based on silicon locally resonant phononic crystal

    Science.gov (United States)

    Jiang, Wanli; Feng, Duan; Xu, Dehui; Xiong, Bin; Wang, Yuelin

    2016-10-01

    In this paper, energy localization in line-defect resonator based on locally resonant phononic crystal (PnC) is experimentally studied. The defected resonator is realized by creating line defects on a two-dimension (2-D) silicon PnC. The silicon resonator was fabricated by micro machining process and tested by a combination of the fluid coupling method and Laser Doppler Vibrometer (LDV). Acoustic waves with frequency range from 7.19 MHz to 7.50 MHz are trapped in the cavity, and the corresponding resonant modes are observed in-situ. The measured quality (Q) factor of the resonator, which is 427 at its resonant frequency of 7.3 MHz, is smaller than the simulated ones (666 and 5135). The experimental results agree well with the simulation results that frequencies of the trapped acoustic waves of are mostly in the range of the phononic bandgaps. The locally resonant based PnC resonator in paper with 17 dB magnitude amplification, which is normalized with respect to the transmission of a freestanding silicon slab in the same frequency range, has great potential in energy harvesting or sound concentration.

  4. Micro

    African Journals Online (AJOL)

    2007-10-01

    Oct 1, 2007 ... Oduyebo, Department of Medical Microbiology and Parasitology, College of Medicine, .... bacteria were identified by standard laboratory methods ... Psychiatric ward in LUTH. ... RGH (theatre and the accident and emergency).

  5. Application of Ultra-Small Micro Grinding and Micro Milling Tools: Possibilities and Limitations

    Directory of Open Access Journals (Sweden)

    Benjamin Kirsch

    2017-08-01

    Full Text Available Current demands for flexible, individual microstructures in high quality result in high requirements for micro tools. As the tool size defines the minimum structure size, ultra-small tools are needed. To achieve tool diameters of 50 µm and lower, we investigate the complete manufacturing chain of micro machining. From the development of the machine tools and components needed to produce and apply the micro tools, the micro tools themselves, as well as the micro machining processes. Machine tools are developed with the possibility of producing the micro geometry (cutting edge design of micro tools as well as plating processes to produce super abrasive micro grinding tools. Applying these setups, we are able to produce ultra-small micro grinding and micro milling tools with typical diameters of 50 µm and down to 4 µm. However, the application of such tools is very challenging. The article presents possibilities and limitations in manufacturing the micro tools themselves as well as microstructures made with these tools. A special emphasis will be on the influence of the tool substrate in micro milling and grain sizes in micro grinding.

  6. Wafer integrated micro-scale concentrating photovoltaics

    Science.gov (United States)

    Gu, Tian; Li, Duanhui; Li, Lan; Jared, Bradley; Keeler, Gordon; Miller, Bill; Sweatt, William; Paap, Scott; Saavedra, Michael; Das, Ujjwal; Hegedus, Steve; Tauke-Pedretti, Anna; Hu, Juejun

    2017-09-01

    Recent development of a novel micro-scale PV/CPV technology is presented. The Wafer Integrated Micro-scale PV approach (WPV) seamlessly integrates multijunction micro-cells with a multi-functional silicon platform that provides optical micro-concentration, hybrid photovoltaic, and mechanical micro-assembly. The wafer-embedded micro-concentrating elements is shown to considerably improve the concentration-acceptance-angle product, potentially leading to dramatically reduced module materials and fabrication costs, sufficient angular tolerance for low-cost trackers, and an ultra-compact optical architecture, which makes the WPV module compatible with commercial flat panel infrastructures. The PV/CPV hybrid architecture further allows the collection of both direct and diffuse sunlight, thus extending the geographic and market domains for cost-effective PV system deployment. The WPV approach can potentially benefits from both the high performance of multijunction cells and the low cost of flat plate Si PV systems.

  7. Experimental identification of microRNA targets

    DEFF Research Database (Denmark)

    Ørom, Ulf Andersson; Lund, Anders H

    2009-01-01

    microRNAs are small RNAs that regulate protein synthesis post-transcriptionally. Animal microRNAs recognize their targets by incomplete base pairing to sequence motifs most often present in the 3' untranslated region of their target mRNAs. This partial complementarity vastly expands the repertoire...... of potential targets and constitutes a problem for computational target prediction. Although computational analyses have shed light on important aspects of microRNA target recognition, several questions remain regarding how microRNAs can recognize and regulate their targets. Forward experimental approaches...... allow for an unbiased study of microRNA target recognition and may unveil novel, rare or uncommon target binding patterns. In this review we focus on animal microRNAs and the experimental approaches that have been described for identification of their targets....

  8. Micro Evolutionary Processes and Adaptation

    Institute of Scientific and Technical Information of China (English)

    SHADMANOV R K; RUBAN I N; VOROPAEVA N L; SHADMANOVA A R

    2008-01-01

    @@ It would be well to note that in the absence of clear data about the formation of adaptation systems,or mechanisms of their occurrence,all that is recognized is the realization of the micro evolutionary processes.There is no well-defined connection between information exchange and formation of adaptation systems.Obviously,it occurs because mechanisms and systems reacting to any external actions are not considered from the point of view of "coexistence" of dynamic and static processes and structures.

  9. Micro-unmanned aerodynamic vehicle

    Science.gov (United States)

    Reuel, Nigel; Lionberger, Troy A.; Galambos, Paul C.; Okandan, Murat; Baker, Michael S.

    2008-03-11

    A MEMS-based micro-unmanned vehicle includes at least a pair of wings having leading wing beams and trailing wing beams, at least two actuators, a leading actuator beam coupled to the leading wing beams, a trailing actuator beam coupled to the trailing wing beams, a vehicle body having a plurality of fulcrums pivotally securing the leading wing beams, the trailing wing beams, the leading actuator beam and the trailing actuator beam and having at least one anisotropically etched recess to accommodate a lever-fulcrum motion of the coupled beams, and a power source.

  10. Ethnic diversity of the micro-context and social trust: Evidence from Denmark

    DEFF Research Database (Denmark)

    Dinesen, Peter Thisted; Sønderskov, Kim Mannemar

    imprecise and downward biased (due to attenuation bias). In the present paper we add to the literature by analyzing, as the first study ever, how ethnic diversity of the immediate micro-context affects people’s trust in others. In addition, we compare the effect in the micro context to the impact of ethnic...... with data from the national Danish registers. The latter data contain detailed information about the ethnic background and the address of everyone living in Denmark. This enables us to obtain precise measures of ethnic diversity of the immediate surroundings in which each respondent lives. In the analysis...... we include measures of ethnic diversity in contextual units ranging from a radius of 80 meters up to 2750 meters within the address of a given respondent. In line with our expectations, the results show that increased ethnic diversity in the immediate surroundings affects generalized trust negatively...

  11. Contamination Study of Micro Pulsed Plasma Thruster

    Science.gov (United States)

    2008-03-01

    Micro propulsion vacuum facility ...................................................... 26 Figure 16. Oil Diffusion pump of the vacuum facility...increasing interest in the so-called micro - and nano -satellites, which are highly maneuverable and have lower cost. These small satellites are aimed to...option to create very small impulse bits for micro - and nano -satellites. Numerous researchers have studied PPTs but µPPTs are a new technology and need a

  12. CURRENT TRENDS OF MICRO- AND NANOMECHANICS

    Institute of Scientific and Technical Information of China (English)

    Wanlin Guo; Huiming Xie; Quanshui Zheng

    2009-01-01

    @@ Introduction Scaling down to the micro- and nanoscale is a strong current trend in the development of science and technology. 'Small is energy efficient and cost effective' has long been for the motto of the semiconductor industry, including micro- and nanoelectronics, micro-electro-mechanical systems (MEMS) and nano- electro-mechanical systems (NEMS). But shrinking to small scales brings big challenges to traditional disciplines, including mechanics.

  13. Fabrication of Micro Components by Electrochemical Deposition

    DEFF Research Database (Denmark)

    Tang, Peter Torben

    The main issue of this thesis is the combination of electrochemical deposition of metals and micro machining. Processes for electroplating and electroless plating of nickel and nickel alloys have been developed and optimised for compatibility with microelectronics and silicon based micromechanics...... of electrochemical machining and traditional machining is compared to micro machining techniques as performed in the field of microelectronics. Various practical solutions and equipment for electrochemical deposition of micro components are demonstrated, as well as the use and experience obtained utilising...

  14. Measurement of micro moulded parts by Computed Tomography and comparison to optical and tactile techniques

    DEFF Research Database (Denmark)

    Yagüe, J.A.; Tosello, Guido; Carmignato, S

    2011-01-01

    This paper focuses on dimensional verification of two micro-injection moulded components, selected from actual industrial productions, using CT metrological tools. In addition to CT scanning, also a tactile Coordinate Measuring Machine (CMM) with sub-micrometer uncertainty and an Optical Coordinate...... Measuring Machine (OCMM) allowing fast measurements suitable for in-line quality control were employed as validation instruments. The experimental work carried out and the analysis of the results provide valuable conclusions about the advantages and drawbacks of using CT metrology in comparison with CMM...

  15. Development of 3d micro-nano hybrid patterns using anodized aluminum and micro-indentation

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Hong Gue; Kwon, Jong Tae [Division of Mechanical Engineering and Mechatronics, Kangwon National University, 1 Kangwondaehakgil, Chunchon, Gangwon-do, 200-701 (Korea, Republic of); Seo, Young Ho [Division of Mechanical Engineering and Mechatronics, Kangwon National University, 1 Kangwondaehakgil, Chunchon, Gangwon-do, 200-701 (Korea, Republic of)], E-mail: mems@kangwon.ac.kr; Kim, Byeong Hee [Division of Mechanical Engineering and Mechatronics, Kangwon National University, 1 Kangwondaehakgil, Chunchon, Gangwon-do, 200-701 (Korea, Republic of)

    2008-07-31

    We developed a simple and cost-effective method of fabricating 3D micro-nano hybrid patterns in which micro-indentation is applied on the anodized aluminum substrate. Nano-patterns were formed first on the aluminum substrate, and then micro-patterns were fabricated by deforming the nano-patterned aluminum substrate. Hemispherical nano-patterns with a 150 nm-diameter on an aluminum substrate were fabricated by anodizing and alumina removing process. Then, micro-pyramid patterns with a side-length of 50 {mu}m were formed on the nano-patterns using micro-indentation. To verify 3D micro-nano hybrid patterns, we replicated 3D micro-nano hybrid patterns by a hot-embossing process. 3D micro-nano hybrid patterns may be used in nano-photonic devices and nano-biochips applications.

  16. Micro tube heat exchangers for Space Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Mezzo fabricates micro tube heat exchangers for a variety of applications, including aerospace, automotive racing, Department of Defense ground vehicles, economizers...

  17. Photolithography and Micro-Fabrication/ Packaging Laboratories

    Data.gov (United States)

    Federal Laboratory Consortium — The Photolithography and Micro-Fabrication/Packaging laboratories provide research level semiconductor processing equipment and facilities that do not require a full...

  18. Modeling of a piezoelectric micro-scanner

    CERN Document Server

    Chaehoi, A; Cornez, D; Kirk, K

    2008-01-01

    Micro-scanners have been widely used in many optical applications. The micro-scanner presented in this paper uses multimorph-type bending actuators to tilt a square plate mirror. This paper presents a complete analytical model of the piezoelectric micro-scanner. This theoretical model based on strength of material equations calculates the force generated by the multimorphs on the mirror, the profile of the structure and the angular deflection of the mirror. The proposed model, used to optimize the design of the piezoelectric silicon micro-scanner, is intended for further HDL integration, allowing in this way system level simulation and optimization.

  19. Classification of assembly techniques for micro products

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Tosello, Guido; Gegeckaite, Asta

    2005-01-01

    Industrial production of micro products to be introduced in the market has to be reliable, fast, carried out at a reasonable price and in an acceptable quantity. One of the crucial steps in the process chain related to micro product manufacture is the assembly phase. Here components are handled...... of components and level of integration are made. This paper describes a systematic characterization of micro assembly methods. This methodology offers the opportunity of a cross comparison among different techniques to gain a choosing principle of the favourable micro assembly technology in a specific case...

  20. Challenging the sustainability of micro products development

    DEFF Research Database (Denmark)

    De Grave, Arnaud; Olsen, Stig Irving

    2006-01-01

    Environmental aspects are one of the biggest concerns regarding the future of manufacturing and product development sustainability. Furthermore, micro products and micro technologies are often seen as the next big thing in terms of possible mass market trend and boom. Many questions are raised......) will be presented, together with some tools used in order to implement the concepts into design activities. Micro injection moulded components and MEMS are used as examples. Specificities of micro products will be investigated through a categorization in three levels: the end products, the whole production chain...

  1. Assembly planning at the micro scale

    Energy Technology Data Exchange (ETDEWEB)

    Feddema, J.T.; Xavier, P.; Brown, R.

    1998-05-14

    This paper investigates a new aspect of fine motion planning for the micro domain. As parts approach 1--10 {micro}m or less in outside dimensions, interactive forces such as van der Waals and electrostatic forces become major factors which greatly change the assembly sequence and path plans. It has been experimentally shown that assembly plans in the micro domain are not reversible, motions required to pick up a part are not the reverse of motions required to release a part. This paper develops the mathematics required to determine the goal regions for pick up, holding, and release of a micro-sphere being handled by a rectangular tool.

  2. Motion Control of Micro-/Nanomotors.

    Science.gov (United States)

    Teo, Wei Zhe; Pumera, Martin

    2016-10-10

    As we progress towards employing self-propelled micro-/nanomotors in envisioned applications such as cargo delivery, environmental remediation, and therapeutic treatments, precise control of the micro-/nanomotors direction and their speed is essential. In this Review, major emerging approaches utilized for the motion control of micro-/nanomotors have been discussed, together with the lastest publications describing these approaches. Future studies could incorporate investigations on micro-/nanomotors motion control in a real-world environment in which matrix complexity might disrupt successful manipulation of these small-scale devices. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Classification of assembly techniques for micro products

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Tosello, Guido; Gegeckaite, Asta

    2005-01-01

    Industrial production of micro products to be introduced in the market has to be reliable, fast, carried out at a reasonable price and in an acceptable quantity. One of the crucial steps in the process chain related to micro product manufacture is the assembly phase. Here components are handled...... of components and level of integration are made. This paper describes a systematic characterization of micro assembly methods. This methodology offers the opportunity of a cross comparison among different techniques to gain a choosing principle of the favourable micro assembly technology in a specific case...

  4. 17% mc-Si solar cell efficiency using completely in-line processing with improved texturing and screen-printed contacts on lowly doped emitters

    Energy Technology Data Exchange (ETDEWEB)

    Weeber, A.W.; Granek, F.J.; Hoornstra, J.; Koppes, M.; Kossen, E.J.; Rieffe, H.C.; Romijn, I.G.; Tool, C.J.J. [ECN Solar Energy, Petten (Netherlands)

    2005-06-01

    A simple in-line industrial process has been developed for commercial multicrystalline silicon (mc-Si) which results in solar cells with an average efficiency of 16.5%. The best cell has an independently confirmed efficiency of 17.0%. These are the highest efficiencies reported for full inline processing. The process consists of an acidic etch for texturing, homogeneous spin-on phosphorous and a belt furnace emitter diffusion, MicroWave PECVD of silicon nitride layers, and screen-printed metallization. The silicon nitride layer serves as antireflection coating and provides bulk and surface passivation. Detailed characterization and computer simulation show that implementation of already proven technologies in the current cell processing can lead to efficiencies around 18%.

  5. Phase contrast micro-CT with an ultrafast laser-based x-ray source

    Science.gov (United States)

    Toth, R.; Kieffer, J. C.; Krol, A.; Fourmaux, S.; Ozaki, T.; Ye, H.; Kincaid, R. E., Jr.; Rakhman, A.

    2005-08-01

    We investigated performance of ultrafast laser-based x-ray source for phase contrast imaging in 2D projection imaging and in enhanced micro-CT imaging. Good quality images were obtained, including images of small animals, in the single energy and multiple energy, in line phase-contrast enhancing geometry using x-ray line energy matching object thickness and density. Phase information has been inferred from images obtained at the same x-ray energy but at different object-to-detector distances and also from images obtained at the same object-to-detector distance but with different K-alpha line energies. Ultrafast laser-based, compact, x-ray source is a promising technique for micro-CT systems. Its utilization might result in faster scans with lower radiation dose, better spatial and contrast resolution and also femtosecond temporal resolution. In addition, it might allow practical implementation of dual-energy and phase-contrast imaging micro-CT that is not possible with conventional micro-CT.

  6. Stretchable Micro-Electrode Array

    Energy Technology Data Exchange (ETDEWEB)

    Maghribi, M; Hamilton, J; Polla, D; Rose, K; Wilson, T; Krulevitch, P

    2002-03-08

    This paper focuses on the design consideration, fabrication processes and preliminary testing of the stretchable micro-electrode array. We are developing an implantable, stretchable micro-electrode array using polymer-based microfabrication techniques. The device will serve as the interface between an electronic imaging system and the human eye, directly stimulating retinal neurons via thin film conducting traces and electroplated electrodes. The metal features are embedded within a thin ({approx}50 micron) substrate fabricated using poly (dimethylsiloxane) (PDMS), a biocompatible elastomeric material that has very low water permeability. The conformable nature of PDMS is critical for ensuring uniform contact with the curved surface of the retina. To fabricate the device, we developed unique processes for metalizing PDMS to produce robust traces capable of maintaining conductivity when stretched (5%, SD 1.5), and for selectively passivating the conductive elements. An in situ measurement of residual strain in the PDMS during curing reveals a tensile strain of 10%, explaining the stretchable nature of the thin metalized devices.

  7. MicroRNAs in Metabolism

    DEFF Research Database (Denmark)

    Vienberg, Sara; Geiger, Julian; Madsen, Søren

    2017-01-01

    MicroRNAs (miRNAs) have within the past decade emerged as key regulators of metabolic homeostasis. Major tissues in intermediary metabolism important during development of the metabolic syndrome, such as β-cells, liver, skeletal and heart muscle as well as adipose tissue have all been shown to be...... diabetes and atherosclerosis stresses their potential as therapeutic targets. This review emphasizes current ideas and controversies within miRNA research in metabolism. This article is protected by copyright. All rights reserved.......MicroRNAs (miRNAs) have within the past decade emerged as key regulators of metabolic homeostasis. Major tissues in intermediary metabolism important during development of the metabolic syndrome, such as β-cells, liver, skeletal and heart muscle as well as adipose tissue have all been shown...... to be affected by miRNAs. In the pancreatic β-cell a number of miRNAs are important in maintaining the balance between differentiation and proliferation (miR-200 and miR-29 families) and insulin exocytosis in the differentiated state is controlled by miR-7, miR-375 and miR-335. MiR-33a and -33b play crucial...

  8. Laser surface micro-/nano-structuring by a simple transportable micro-sphere lens array

    NARCIS (Netherlands)

    Sedao, X.; Derrien, T.J.Y.; Romer, G.W.R.B.E.; Pathiraj, B.; Huis in 't Veld, A.J.

    2012-01-01

    A micro-sphere array optic was employed for laser surface micro-structuring. This array optic consists of a hexagonally close-packed monolayer of silica micro-spheres. It was organized through a self-assembly process and held together on a glass support, without using any adhesives. The array assemb

  9. Laser surface micro-/nano-structuring by a simple transportable micro-sphere lens array

    NARCIS (Netherlands)

    Sedao, X.; Derrien, T.J.Y.; Romer, G.W.R.B.E.; Pathiraj, B.; Huis in 't Veld, A.J.

    2012-01-01

    A micro-sphere array optic was employed for laser surface micro-structuring. This array optic consists of a hexagonally close-packed monolayer of silica micro-spheres. It was organized through a self-assembly process and held together on a glass support, without using any adhesives. The array

  10. Reference micro-objects and procedures to establish traceability in micro metrology

    DEFF Research Database (Denmark)

    Gasparin, Stefania; Tosello, Guido; Hansen, Hans Nørgaard

    2011-01-01

    The report presents methods and procedure to establish the traceability of measurements at both micro and sub-micro dimensional scales. Reference artefacts and new methodologies to ensure traceability of dimensional and geometrical 3D measurements (absolute dimensions below 3 mm, micro features w...

  11. Micro RNA and skin%Micro RNA与皮肤

    Institute of Scientific and Technical Information of China (English)

    许文嵘; 范卫新

    2010-01-01

    micro RNA(miRNA)是一种长约22 nt的非编码RNA,在众多生物体内已发现了许多种miRNA,它们大多数在进化上高度保守,在生物体的发育,细胞的增殖、分化、凋亡以及肿瘤的发生中起着重要的作用.皮肤作为人体最大的一个器官,miRNA在其中也起了许多重要作用.该文就近年来miRNA在皮肤病学中的研究进展作一综述.

  12. In-Line Fiber Optic Interferometric Sensors in Single-Mode Fibers

    Directory of Open Access Journals (Sweden)

    De-Wen Duan

    2012-08-01

    Full Text Available In-line fiber optic interferometers have attracted intensive attention for their potential sensing applications in refractive index, temperature, pressure and strain measurement, etc. Typical in-line fiber-optic interferometers are of two types: Fabry-Perot interferometers and core-cladding-mode interferometers. It’s known that the in-line fiber optic interferometers based on single-mode fibers can exhibit compact structures, easy fabrication and low cost. In this paper, we review two kinds of typical in-line fiber optic interferometers formed in single-mode fibers fabricated with different post-processing techniques. Also, some recently reported specific technologies for fabricating such fiber optic interferometers are presented.

  13. Monitoring the production of FRP composites: A review of in-line sensing methods

    National Research Council Canada - National Science Library

    Konstantopoulos, S; Fauster, E; Schledjewski, R

    2014-01-01

    .... Monitoring the running process (in-line monitoring) eliminates the need for prediction; real time data provided by appropriate sensing systems can be used in the direction of process optimization, quality upgrade or material characterization...

  14. In-line estimation of sulfur and nitrogen contents during hydrotreating of middle distillates

    Directory of Open Access Journals (Sweden)

    M. E. Pacheco

    2009-12-01

    Full Text Available The main objective of this work is analyzing whether it is possible to develop an empirical correlation for in-line estimation of the sulfur and nitrogen contents of the middle distillates Hydrotreating (HDT products for control purposes. Correlations are based only on readily available in-line information of specific gravity variation between feedstock and products, without considering any piece of information about the kinetic behavior of the catalyst. Experimental data were obtained in pilot plants under operating conditions that are representative of refinery operations. Results indicate that the removal of nitrogen and sulfur compounds during middle distillates HDT can be monitored in-line in real time, based on the available measurements of specific gravity. This allows for development and implementation of advanced in-line procedures for monitoring and control of the HDT process in real time.

  15. Micro-assembly of a Vascular-like Micro-channel with Railed Micro-robot Team-coordinated Manipulation

    Directory of Open Access Journals (Sweden)

    Huaping Wang

    2014-07-01

    strategies were evaluated based on the assembly of micro-donuts. Through the novel, designed, concentric movement of the multi-manipulators along the rail, arbitrary change of the approaching angle and the coordination posture was achieved to improve the micro-assembly’s flexibility. The operation range for every micromanipulator in different coordinated manipulation modes was analysed to avoid the breakdown of the assembled 3D structure. The image processing for the target location and end-effector identification was conducted to improve assembly efficiency in the micro-robot-team system. Finally, the assembly of the cellular vascular-like micro-channel was achieved with coordinated manipulation in the rail- guided micro-robot-team system.

  16. Integrated Micro Product and Technology Development

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard

    2003-01-01

    The paper addresses the issues of integrated micro product and technology development. The implications of the decisions in the design phase on the subsequent manufacturing processes are considered vital. A coherent process chain is a necessary prerequisite for the realisation of the industrial...... potential of micro technology....

  17. Characterization of Micro-arc Oxidized Titanium

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The observation of the sparkling discharges during the micro-arc oxidation process in KOH aqueous electrolyte was achieved. The change of surface morphology was progressively observed and a plausible pore formation mechanism is proposed. Cell proliferation and ALP activity of micro-arc oxidized titanium was evaluated by human body derived osteoblasts and slightly better than those of blasted surface.

  18. Report on tolerancing guidelines for micro manufacturing

    DEFF Research Database (Denmark)

    Gasparin, Stefania; Tosello, Guido; Hansen, Hans Nørgaard

    2011-01-01

    The present report underlines some problematic aspects of the micro manufacturing in order to develop tolerancing guidelines based on the industrial needs of the partners in the project. Some solutions were given through the investigation and characterization of three different micro-nano injection...

  19. Integrated Micro Product and Technology Development

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard

    2003-01-01

    The paper addresses the issues of integrated micro product and technology development. The implications of the decisions in the design phase on the subsequent manufacturing processes are considered vital. A coherent process chain is a necessary prerequisite for the realisation of the industrial...... potential of micro technology....

  20. The Aarhus Ion Micro-Trap Project

    DEFF Research Database (Denmark)

    Miroshnychenko, Yevhen; Nielsen, Otto; Poulsen, Gregers

    and installed in an ultra high vacuum chamber, which includes an ablation oven for all-optical loading of the trap [2]. The next steps on the project are to demonstrate the operation of the micro-trap and the cooling of ions using fiber delivered light. [1] D. Grant, Development of Micro-Scale Ion traps, Master...

  1. Micro-optics: manufacturing and characterization

    Science.gov (United States)

    Voelkel, R.; Eisner, M.; Weible, K. J.

    2005-10-01

    Wafer-based manufacturing of Micro-Optics is based on standard technologies from Semiconductor Industry, like resist coating, lithography, reactive ion etching, deposition, sputtering, and lift-off. These well-established technologies allow the manufacturing of almost any Micro-Optics' structure shape. The excellence of the Micro-Optics component depends much on the proper choice of the manufacturing equipment and the process control. As all processes are standard Semiconductor technology, the quality is merely a question of the budget and the optimization effort. For characterization and testing, the current situation is different. Neither the test equipment from Semiconductor industry nor the test equipment from classical optics manufacturing is suitable to for Micro-Optics. Most of test instruments Micro-Optics industry is using today have been developed by research institutes or by the manufacturing companies themselves. As Micro-Optics is still a niche market, all instruments are built in small series. This lack of suitable test equipment is a major problem for the Micro-Optics industry today. All process optimization in manufacturing is closely related to the capability to measure the quality of the products. We report on the state of the art in wafer-based manufacturing and summarize the standard characterization tools for Micro-Optics.

  2. Micro hydro-electric power stations

    Energy Technology Data Exchange (ETDEWEB)

    Monition, L.; Le Nir, M.; Roux, J.

    1984-01-01

    This book provides a discussion of all aspects of hydro-power exploitation using micro-power stations. It offers guidance to techniques for assessing the power available from a given stream, designing and building siteworks, selecting the appropriate turbine types for given conditions, and measuring and controlling environmental hazards associated with micro-hydro installations.

  3. Can micro-volunteering help in Africa?

    CSIR Research Space (South Africa)

    Butgereit, L

    2013-05-01

    Full Text Available is convenient to the micro-volunteer, and in small pieces of time (bitesized). This paper looks at a micro-volunteering project where participants can volunteer for five to ten minutes at a time using a smart phone and assist pupils with their mathematics....

  4. Report on tolerancing guidelines for micro manufacturing

    DEFF Research Database (Denmark)

    Gasparin, Stefania; Tosello, Guido; Hansen, Hans Nørgaard

    2011-01-01

    The present report underlines some problematic aspects of the micro manufacturing in order to develop tolerancing guidelines based on the industrial needs of the partners in the project. Some solutions were given through the investigation and characterization of three different micro-nano injecti...... moulded components: a toggle for hearing aid application, CD/DVD/HD-DVD and, finally, Fresnel lenses....

  5. RFP for CNES micro satellite program

    DEFF Research Database (Denmark)

    Jørgensen, John Leif; Jørgensen, Finn E; Betto, Maurizio

    1999-01-01

    This document descibes the ASC STAR TRACKER (performance, functionality, requirements etc.) to the Centre National d'Etudes Spatiales (CNES) for their micro Satellites.......This document descibes the ASC STAR TRACKER (performance, functionality, requirements etc.) to the Centre National d'Etudes Spatiales (CNES) for their micro Satellites....

  6. Micro/nanoscale continuous printing: direct-writing of wavy micro/nano structures via electrospinning

    Science.gov (United States)

    Fang, Feiyu; Du, Zefeng; Zeng, Jun; Zhu, Ziming; Chen, Xin; Chen, Xindu; Lv, Yuanjun; Wang, Han

    2015-07-01

    Micro/nanofibers that are created by direct-writing using an electrospinning (ES) technique have aroused much recent attention, owing to their intriguing physical properties and great potential as building blocks for micro/nanoscale devices. In this work, a wavy direct-writing (WDW) process was developed to directly write wavy micro/nanostructures suitable for the fabrication of micro/nanoscale devices. The low voltage WDW technique is anticipated to be useful for a broad range of applications including flexible/stretchable electronics, micro optoelectronics, nano-antennas, microelectromechanical systems (MEMS), and biomedical engineering.

  7. Micro powder injection molding——large scale production technology for micro-sized components

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Micro powder injection molding (μPIM),a miniaturized variant of powder injection molding,has advantages of shape complexity,applicability to many materials and good mechanical properties. Co-injection molding has been realized between met-als and ceramics on micro components,which become the first breakthrough within the PIM field. Combined with the prominent characteristics of high features/cost ratio,micro powder injection molding becomes a potential technique for large scale production of intricate and three-dimensional micro components or micro-structured components in microsystems technology (MST) field.

  8. Micro injection moulding process validation for high precision manufacture of thermoplastic elastomer micro suspension rings

    DEFF Research Database (Denmark)

    Calaon, M.; Tosello, G.; Elsborg Hansen, R.

    Micro injection moulding (μIM) is one of the most suitable micro manufacturing processes for flexible mass-production of multi-material functional micro components. The technology was employed in this research used to produce thermoplastic elastomer (TPE) micro suspension rings identified...... as critical component in micro acoustic applications (e.g. phono cartridges, see Figure 1a). The suspension ring holds in place the preassembled aluminium cantilever, magnet and diamond tip seen (see Figure 1b and 1c). The specific damping properties of the TPE material reduces vibrations differently depended...

  9. MicroRNAs in neurodegeneration.

    Science.gov (United States)

    Bushati, Natascha; Cohen, Stephen M

    2008-06-01

    microRNAs (miRNAs) act as post-transcriptional regulators of gene expression in diverse cellular and developmental processes. Many miRNAs are expressed specifically in the central nervous system, where they have roles in differentiation, neuronal survival, and potentially also in plasticity and learning. The absence of miRNAs in a variety of specific postmitotic neurons can lead to progressive loss of these neurons and behavioral defects reminiscent of the phenotypes seen in the pathologies of neurodegenerative diseases. Here, we review recent studies which provide a link between miRNA function and neurodegeneration. We also discuss evidence which might suggest involvement of miRNAs in the emergence or progression of neurodegenerative diseases.

  10. Trophoblasts, invasion and micro RNA

    Directory of Open Access Journals (Sweden)

    Ludivine eDoridot

    2013-11-01

    Full Text Available MicroRNAs (miRNAs have recently become essential actors in various fields of physiology and medicine, especially as easily accessible circulating biomarkers, or as modulators of cell differentiation. To this respect, terminal differentiation of trophoblasts (the characteristic cells of the placenta in Therian mammals into syncytiotrophoblast, villous trophoblast or extravillous trophoblast constitutes a good example of such a choice, where miRNAs have recently been shown to play an important role. The aim of this review is to provide a snapshot of what is known today in placentation mechanisms that are mediated by miRNA, under the angles of materno-foetal immune dialogue regulation, trophoblast differentiation and angiogenesis at the materno-foetal interface. Also, two aspects of regulation of these issues will be highlighted: the part played by oxygen concentration and the specific function of imprinted genes in the developing placenta.

  11. Micro-modulated luminescence tomography

    CERN Document Server

    Cong, Wenxiang; Wang, Chao; Wang, Ge

    2013-01-01

    Imaging depth of optical microscopy has been fundamentally limited to millimeter or sub-millimeter due to light scattering. X-ray microscopy can resolve spatial details of few microns deeply inside a sample but the contrast resolution is still inadequate to depict heterogeneous features at cellular or sub-cellular levels. To enhance and enrich biological contrast at large imaging depth, various nanoparticles are introduced and become essential to basic research and molecular medicine. Nanoparticles can be functionalized as imaging probes, similar to fluorescent and bioluminescent proteins. LiGa5O8:Cr3+ nanoparticles were recently synthesized to facilitate luminescence energy storage with x-ray pre-excitation and the subsequently stimulated luminescence emission by visible/near-infrared (NIR) light. In this paper, we suggest a micro-modulated luminescence tomography (MLT) approach to quantify a nanophosphor distribution in a thick biological sample with high resolution. Our numerical simulation studies demonst...

  12. MEMS Based Micro Aerial Vehicles

    Science.gov (United States)

    Joshi, Niranjan; Köhler, Elof; Enoksson, Peter

    2016-10-01

    Designing a flapping wing insect robot requires understanding of insect flight mechanisms, wing kinematics and aerodynamic forces. These subsystems are interconnected and their dependence on one another affects the overall performance. Additionally it requires an artificial muscle like actuator and transmission to power the wings. Several kinds of actuators and mechanisms are candidates for this application with their own strengths and weaknesses. This article provides an overview of the insect scaled flight mechanism along with discussion of various methods to achieve the Micro Aerial Vehicle (MAV) flight. Ongoing projects in Chalmers is aimed at developing a low cost and low manufacturing time MAV. The MAV design considerations and design specifications are mentioned. The wings are manufactured using 3D printed carbon fiber and are under experimental study.

  13. Dysregulated microRNAs in neurodegenerative disorders.

    Science.gov (United States)

    Lau, Pierre; de Strooper, Bart

    2010-09-01

    The complexity of the nervous system arises in part, from the large diversity of neural cell types that support the architecture of neuronal circuits. Recent studies have highlighted microRNAs as important players in regulating gene expression at the post-transcriptional level and therefore the phenotype of neural cells. A link between microRNAs and neurodegenerative diseases such as Alzheimer's disease, Huntington's disease and Parkinson's disease is becoming increasingly evident. Here, we discuss microRNAs in neurodegeneration, from the fruit fly and mouse utilized as experimental models to dysregulated microRNAs in human neurodegenerative disorders. We propose that studying microRNAs and their mRNA targets in the context of neurodegeneration will significantly contribute to the identification of proteins important for neuronal function and might reveal underlying molecular networks that drive these diseases.

  14. Biologically Inspired Micro-Flight Research

    Science.gov (United States)

    Raney, David L.; Waszak, Martin R.

    2003-01-01

    Natural fliers demonstrate a diverse array of flight capabilities, many of which are poorly understood. NASA has established a research project to explore and exploit flight technologies inspired by biological systems. One part of this project focuses on dynamic modeling and control of micro aerial vehicles that incorporate flexible wing structures inspired by natural fliers such as insects, hummingbirds and bats. With a vast number of potential civil and military applications, micro aerial vehicles represent an emerging sector of the aerospace market. This paper describes an ongoing research activity in which mechanization and control concepts for biologically inspired micro aerial vehicles are being explored. Research activities focusing on a flexible fixed- wing micro aerial vehicle design and a flapping-based micro aerial vehicle concept are presented.

  15. Challenging the sustainability of micro products development

    DEFF Research Database (Denmark)

    De Grave, Arnaud; Olsen, Stig Irving

    2006-01-01

    Environmental aspects are one of the biggest concerns regarding the future of manufacturing and product development sustainability. Furthermore, micro products and micro technologies are often seen as the next big thing in terms of possible mass market trend and boom. Many questions are raised...... regarding the impact of size for recycling or environment. Indeed micro production is often seen as environmental friendly thanks to the small amount of material used. Such a statement can be misleading. In this article EcoDesign or Design for Environment (DFE) and Life Cycle Assessment (LCA......) will be presented, together with some tools used in order to implement the concepts into design activities. Micro injection moulded components and MEMS are used as examples. Specificities of micro products will be investigated through a categorization in three levels: the end products, the whole production chain...

  16. Precision moulding of polymer micro components

    DEFF Research Database (Denmark)

    Tosello, Guido

    2008-01-01

    at micro scale, of machine’s dynamic behaviour implementation and of micro geometry modelling was shown in a quantitative study. Insert moulding and hot embossing processes were investigated for the manufacturing of multi-material miniaturized components. A mould was developed and validated......The present research work contains a study concerning polymer micro components manufacturing by means of the micro injection moulding (µIM) process. The overall process chain was considered and investigated during the project, including part design and simulation, tooling, process analysis, part...... optimization, quality control, multi-material solutions. A series of experimental investigations were carried out on the influence of the main µIM process factors on the polymer melt flow within micro cavities. These investigations were conducted on a conventional injection moulding machine adapted...

  17. Improving metrology for micro-optics manufacturing

    Science.gov (United States)

    Davies, Angela D.; Bergner, Brent C.; Gardner, Neil W.

    2003-11-01

    Metrology is one of the critical enabling technologies for realizing the full market potential for micro-optical systems. Measurement capabilities are currently far behind present and future needs. Much of today"s test equipment was developed for the micro-electronics industry and is not optimized for micro-optic materials and geometries. Metrology capabilities currently limit the components that can be realized, in many cases. Improved testing will be come increasingly important as the technology moves to integration where it will become important to "test early and test often" to achieve high yields. In this paper, we focus on micro-refractive components in particular, and describe measurement challenges for this class of components and current and future needs. We also describe a new micro-optics metrology research program at UNC Charlotte under the Center for Precision Metrology and the new Center for Optoelectronics and Optical Communications to address these needs.

  18. Laser beam micro-milling of micro-channels in aerospace alloys

    CERN Document Server

    Ahmed, Naveed; Al-Ahmari, Abdulrahman

    2017-01-01

    This volume is greatly helpful to micro-machining and laser engineers as it offers obliging guidelines about the micro-channel fabrications through Nd:YAG laser beam micro-milling. The book also demonstrates how the laser beam micro-milling behaves when operating under wet conditions (under water), and explores what are the pros and cons of this hybrid technique. From the predictive mathematical models, the readers can easily estimate the resulting micro-channel size against the desired laser parametric combinations. The book considers micro-channels in three highly important research materials commonly used in aerospace industry: titanium alloy Ti-6Al-4V, nickel alloy Inconel 718 and aluminum alloy AA 2024. Therefore, the book is highly practicable in the fields of micro-channel heat exchangers, micro-channel aerospace turbine blades, micro-channel heat pipes, micro-coolers and micro-channel pulsating heat plates. These are frequently used in various industries such as aerospace, automotive, biomedical and m...

  19. Toward the promise of microRNAs - Enhancing reproducibility and rigor in microRNA research.

    Science.gov (United States)

    Witwer, Kenneth W; Halushka, Marc K

    2016-11-01

    The fields of applied and translational microRNA research have exploded in recent years as microRNAs have been implicated across a spectrum of diseases. MicroRNA biomarkers, microRNA therapeutics, microRNA regulation of cellular physiology and even xenomiRs have stimulated great interest, which have brought many researchers into the field. Despite many successes in determining general mechanisms of microRNA generation and function, the application of microRNAs in translational areas has not had as much success. It has been a challenge to localize microRNAs to a given cell type within tissues and assay them reliably. At supraphysiologic levels, microRNAs may regulate hosts of genes that are not the physiologic biochemical targets. Thus the applied and translational microRNA literature is filled with pitfalls and claims that are neither scientifically rigorous nor reproducible. This review is focused on increasing awareness of the challenges of working with microRNAs in translational research and recommends better practices in this area of discovery.

  20. Feasibility of small animal cranial irradiation with the microRT system

    Energy Technology Data Exchange (ETDEWEB)

    Kiehl, Erich L.; Stojadinovic, Strahinja; Malinowski, Kathleen T.; Limbrick, David; Jost, Sarah C.; Garbow, Joel R.; Rubin, Joshua B.; Deasy, Joseph O.; Khullar, Divya; Izaguirre, Enrique W.; Parikh, Parag J.; Low, Daniel A.; Hope, Andrew J. [Washington University School of Medicine, St. Louis, Missouri 63110 (United States); Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 (United States); Washington University School of Medicine, St. Louis, Missouri 63110 (United States); Princess Margaret Hospital, Toronto, Ontario M5G 2M9 (Canada)

    2008-10-15

    immobilizer added {+-}0.1 mm to microRT spatial uncertainty along each axis. Overall, the total spatial uncertainty for the prescribed treatments was {+-}0.3 mm in all three axes, a 0.2 mm functional improvement over the original version of microRT. Subject tolerance was good, with minimal observed side effects and a low procedure-induced mortality rate. Throughput was high, with average treatment times of 7.72 and 3.13 min/animal for the whole-brain and hemispheric plans, respectively (dependent on source strength). Conclusions: The method described exhibits conformality more in line with the size differential between human and animal patients than provided by previous prevalent approaches. Using pretreatment imaging and microRT-specific treatment planning, our method can deliver an accurate, conformal dose distribution to the targeted murine brain (or a subregion of the brain) while minimizing excess dose to the surrounding tissue. Thus, preclinical animal studies assessing the radiotherapeutic response of both normal and malignant CNS tissue to complex dose distributions, which closer resemble human-type radiotherapy, are better enabled. The procedural and mechanistic framework for this method logically provides for future adaptation into other murine target organs or regions.

  1. Micro computed tomography for vascular exploration

    Directory of Open Access Journals (Sweden)

    Zhuang Zhen W

    2010-03-01

    Full Text Available Abstract Vascular exploration of small animals requires imaging hardware with a very high spatial resolution, capable of differentiating large as well as small vessels, in both in vivo and ex vivo studies. Micro Computed Tomography (micro-CT has emerged in recent years as the preferred modality for this purpose, providing high resolution 3D volumetric data suitable for analysis, quantification, validation, and visualization of results. The usefulness of micro-CT, however, can be adversely affected by a range of factors including physical animal preparation, numerical quantification, visualization of results, and quantification software with limited possibilities. Exacerbating these inherent difficulties is the lack of a unified standard for micro-CT imaging. Most micro-CT today is aimed at particular applications and the software tools needed for quantification, developed mainly by imaging hardware manufacturers, lack the level of detail needed to address more specific aims. This review highlights the capabilities of micro-CT for vascular exploration, describes the current state of imaging protocols, and offers guidelines and suggestions aimed at making micro-CT more accurate, replicable, and robust.

  2. Fabrication of micro metallic valve and pump

    Science.gov (United States)

    Yang, Ming; Kabasawa, Yasunari; Ito, Kuniyoshi

    2010-03-01

    Fabrication of micro devices by using micro metal forming was proposed by the authors. We developed a desktop servo-press machine with precise tooling system. Precise press forming processes including micro forging and micro joining has been carried out in a progressive die. In this study, micro metallic valve and pump were fabricated by using the precise press forming. The components are made of sheet metals, and assembled in to a unit in the progressive die. A micro check-valve with a diameter of 3mm and a length of 3.2mm was fabricated, and the property of flow resistance was evaluated. The results show that the check valve has high property of leakage proof. Since the valve is a unit parts with dimensions of several millimeters, it has advantage to be adapted to various pump design. Here, two kinds of micro pumps with the check-valves were fabricated. One is diaphragm pump actuated by vibration of the diaphragm, and another is tube-shaped pump actuated by resonation. The flow quantities of the pumps were evaluated and the results show that both of the pumps have high pumping performance.

  3. Development of micro power generators - A review

    Energy Technology Data Exchange (ETDEWEB)

    Chou, S.K.; Yang, W.M.; Chua, K.J.; Li, J. [Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576 (Singapore); Zhang, K.L. [Department of Manufacturing Engineering and Engineering Management, City University of Hong Kong, 83 Tat Chee Avenue (China)

    2011-01-15

    The demand for energy sources that are compact, lightweight and powerful has significantly increased in recent years. Traditional chemical batteries which are highly developed are unable to meet the demand for high energy intensity. This gap is expected to widen in the future as electronic devices need more power to support enhanced functionalities. Hydrocarbon fuels have energy densities much greater than the best batteries. Therefore, taking advantage of the high energy density of chemical fuels to generate power becomes an attractive technological alternative to batteries. To address the growing demand for smaller scale and higher energy density power sources, various combustion-based micro power generators are being developed around the world. This review paper provides an update on recent progresses and developments in micro-scale combustion and micro power generators. The paper, broadly divided into four main sections, begins with a review of various methods to enhance and stabilize the combustion at micro-scale, subsequently improving the efficiency. This is followed by a description of various micro-thermophotovoltaic power generators. The third section focuses on MEMS based solid propellant micro-propulsion system. Lastly, a brief review is made to other micro power generators. (author)

  4. Updating the Micro-Tom TILLING platform.

    Science.gov (United States)

    Okabe, Yoshihiro; Ariizumi, Tohru; Ezura, Hiroshi

    2013-03-01

    The dwarf tomato variety Micro-Tom is regarded as a model system for functional genomics studies in tomato. Various tomato genomic tools in the genetic background of Micro-Tom have been established, such as mutant collections, genome information and a metabolomic database. Recent advances in tomato genome sequencing have brought about a significant need for reverse genetics tools that are accessible to the larger community, because a great number of gene sequences have become available from public databases. To meet the requests from the tomato research community, we have developed the Micro-Tom Targeting-Induced Local Lesions IN Genomes (TILLING) platform, which is comprised of more than 5000 EMS-mutagenized lines. The platform serves as a reverse genetics tool for efficiently identifying mutant alleles in parallel with the development of Micro-Tom mutant collections. The combination of Micro-Tom mutant libraries and the TILLING approach enables researchers to accelerate the isolation of desirable mutants for unraveling gene function or breeding. To upgrade the genomic tool of Micro-Tom, the development of a new mutagenized population is underway. In this paper, the current status of the Micro-Tom TILLING platform and its future prospects are described.

  5. In-line NIR monitoring of key characteristics of enteric coated pellets.

    Science.gov (United States)

    Marković, Snezana; Poljanec, Ksenija; Kerc, Janez; Horvat, Matej

    2014-11-01

    We describe the development of an in-line monitoring approach for the fluid-bed drying and coating steps for the production of enteric coated pellets by NIR. Our results show that key pellet characteristics can be monitored in-line. Likewise, the finished product acidic resistance is in excellent agreement to the in-line NIR predictions. Samples were collected at regular intervals and analyzed by several reference methods to characterize both process steps. In-line NIR models for pellets size sieve fractions, residual solvent content, and amount of coating layer have been constructed. Both the pellet coating layer amount and the in-vitro enteric performance demonstrate low variability which represents a challenge to the usual chemometric model development approach. To overcome this challenge a hierarchical PLS model for predicting acidic resistance was successfully constructed using time-evolving spectral data from 22 batches. Moreover, a novel multivariate meta-analysis of the PLS loadings of individual in-line models and the hierarchical PLS model has identified which pellet characteristics correlate most significantly with the observed enteric performance of the finished product. Additionally, the meta-analysis pointed toward the presence of further mechanisms unrelated to studied characteristics that also significantly influence the acidic resistance.

  6. Dual-energy micro-CT imaging of pulmonary airway obstruction: correlation with micro-SPECT

    Science.gov (United States)

    Badea, C. T.; Befera, N.; Clark, D.; Qi, Y.; Johnson, G. A.

    2014-03-01

    To match recent clinical dual energy (DE) CT studies focusing on the lung, similar developments for DE micro-CT of the rodent lung are required. Our group has been actively engaged in designing pulmonary gating techniques for micro- CT, and has also introduced the first DE micro-CT imaging method of the rodent lung. The aim of this study was to assess the feasibility of DE micro-CT imaging for the evaluation of airway obstruction in mice, and to compare the method with micro single photon emission computed tomography (micro-SPECT) using technetium-99m labeled macroaggregated albumin (99mTc-MAA). The results suggest that the induced pulmonary airway obstruction causes either atelectasis, or air-trapping similar to asthma or chronic bronchitis. Atelectasis could only be detected at early time points in DE micro-CT images, and is associated with a large increase in blood fraction and decrease in air fraction. Air trapping had an opposite effect with larger air fraction and decreased blood fraction shown by DE micro-CT. The decrease in perfusion to the hypoventilated lung (hypoxic vasoconstriction) is also seen in micro-SPECT. The proposed DE micro-CT technique for imaging localized airway obstruction performed well in our evaluation, and provides a higher resolution compared to micro-SPECT. Both DE micro-CT and micro-SPECT provide critical, quantitative lung biomarkers for image-based anatomical and functional information in the small animal. The methods are readily linked to clinical methods allowing direct comparison of preclinical and clinical results.

  7. Micro Nano Replication Processes and Applications

    CERN Document Server

    Kang, Shinill

    2012-01-01

    This book is an introduction to the fundamentals and processes for micro and nano molding for plastic components. In addition to the basics, the book covers applications details and examples. The book helps both students and professionals to understand and work with the growing tools of molding and uses for micro and nano-sized plastic parts.Provides a comprehensive presentation on fundamentals and practices of manufacturing for micro / nano sized plastics partsCovers a relatively new but fast-growing field that is impacting any industry using plastic parts in their products (electronics, tele

  8. Micro-fuel cell power sources

    Energy Technology Data Exchange (ETDEWEB)

    Morse, Jeffrey D. [Center for Meso, Micro, and Nano Technology, Lawrence Livermore National Laboratory, 7000 East Avenue, L-222, Livermore, CA 94550, (United States)

    2007-01-19

    This paper presents a review and discussion of micro-fuel cell technologies, providing insight into the innovations that have been made to date. Discussion of concepts and results leading towards increased levels of integration and performance for micro-fuel cell systems will elucidate the potential of thin film and microfabrication methods in meeting the challenges and requirements necessary for consumer applications. While the amount of literature in this area is substantial, a representative sampling of key developments will be presented in this paper, in order to gain a sense of the design methodologies being implemented for micro-fuel cell power sources. (Author)

  9. Micro-transactions for concurrent data structures

    DEFF Research Database (Denmark)

    Meawad, Fadi; Iyer, Karthik; Schoeberl, Martin;

    2013-01-01

    Transactional memory is a promising technique for enforcing disciplined access to shared data in a multiprocessor system. Transactional memory simplifies the implementation of a variety of concurrent data structures. In this paper, we study the benefits of a modest, real-time aware, hardware...... implementation of transactional memory that we call micro-transactions. In particular, we argue that hardware support for micro-transactions allows us to efficiently implement certain data structures. Those data structures are difficult to realize with the atomic operations provided by stock hardware and provide......, atomic instructions, and micro-transactions. Our results suggest that transactional memory is an interesting alternative to traditional concurrency control mechanisms....

  10. Micro turbine engines for drones propulsion

    Science.gov (United States)

    Dutczak, J.

    2016-09-01

    Development of micro turbine engines began from attempts of application of that propulsion source by group of enthusiasts of aviation model making. Nowadays, the domain of micro turbojet engines is treated on a par with “full size” aviation constructions. The dynamic development of these engines is caused not only by aviation modellers, but also by use of micro turbojet engines by army to propulsion of contemporary drones, i.e. Unmanned Aerial Vehicles (UAV) or Unmanned Aerial Systems (UAS). On the base of selected examples the state of art in the mentioned group of engines has been presented in the article.

  11. Micro satellite mapping of plant genomes

    Directory of Open Access Journals (Sweden)

    Prodanović Slaven

    2001-01-01

    Full Text Available Micro satellites are DNA markers, based on the repeated nucleotide sequences number polymorphism. They belong to a group of PCR markers and are mainly used as an addition to other types of markers. Their characteristics and technical aspects of their application are discussed in the present study. Furthermore, some results obtained by the use of the micro satellite DNA in genetic mapping of plant genomes are also presented. Although micro satellites provide the identification of genotypes within a species, inadequacy of comparative mapping of different species is their serious blemish. .

  12. RESEARCH OF MICRO ELECTRO DISCHARGE MACHININGEQUIPMENT AND PROCESS TECHNIQUES

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Micro electro discharge machining (micro EDM) is a feasible way to manufacture micro structures and has potential application in advanced industrial fields. For the realization of micro EDM, it is necessary to pay careful attention to its equipment design and the development of process techniques. The present status of research and development of micro EDM equipment and process techniques is overviewed. A micro electro discharge machine incorporated with an inchworm type of micro feed mechanism is introduced, and a micro electro discharge machine for drilling micro holes suitable to industrial use is also introduced. Some of the machining experiments carried out on the micro EDM prototypes are shown and the feasibility of the micro EDM technology to practical use is discussed.

  13. Epigenetic microRNA Regulation

    DEFF Research Database (Denmark)

    Wiklund, Erik Digman

    2011-01-01

    MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) that negatively regulate gene expression post-transcriptionally by binding to complementary sequences in the 3’UTR of target mRNAs in the cytoplasm. However, recent evidence suggests that certain miRNAs are enriched in the nucleus......, and their targets do not seem restricted to mRNA 3’UTRs. Therefore, miRNAs are predicted to have a variety functions throughout mammalian cells. MiRNA genes appear to be regulated in much the same way as coding genes, but current insight into transcriptional miRNA control lacks detail, as mapping miRNA promoters...... and confirming transcriptional start sites can be difficult. Epigenetics, gene regulatory and DNA modification mechanisms not involving a change to the primary sequence, have been implied in the regulation of a number of miRNA loci. Both epigenetic and miRNA signatures are broadly altered in cancer...

  14. MICRO AUTO GASIFICATION SYSTEM: EMISSIONS ...

    Science.gov (United States)

    A compact, CONEX-housed waste to energy unit, Micro Auto Gasification System (MAGS), was characterized for air emissions from burning of military waste types. The MAGS unit is a dual chamber gasifier with a secondary diesel-fired combustor. Eight tests were conducted with multiple waste types in a 7-day period at the Kilauea Military Camp in Hawai’i. The emissions characterized were chosen based on regulatory emissions limits as well as their ability to cause adverse health effects on humans: particulate matter (PM), mercury, heavy metals, volatile organic compounds (VOCs), polyaromatic hydrocarbons (PAHs), and polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). Three military waste feedstock compositions reflecting the variety of wastes to be encountered in theatre were investigated: standard waste (SW), standard waste with increased plastic content (HP), standard waste without SW food components but added first strike ration (FSR) food and packaging material (termed FSR). A fourth waste was collected from the Kilauea dumpster that served the dining facility and room lodging (KMC). Limited scrubber water and solid ash residue samples were collected to obtain a preliminary characterization of these effluents/residues.Gasifying SW, HP, and KMC resulted in similar PCDD/PCDF stack concentrations, 0.26-0.27 ng TEQ/m3 at 7% O2, while FSR waste generated a notably higher stack concentration of 0.68 ng TEQ/m3 at 7% O2. The PM emission

  15. MicroRNAs and spermatogenesis.

    Science.gov (United States)

    Kotaja, Noora

    2014-06-01

    In mammals, male gametes are produced inside the testis by spermatogenesis, which has three phases: mitotic proliferation of spermatogonia, meiosis of spermatocytes, and haploid differentiation of spermatids. The genome of male germ cells is actively transcribed to produce phase-specific gene expression patterns. Male germ cells have a complex transcriptome. In addition to protein-coding messenger RNAs, many noncoding RNAs, including microRNAs (miRNAs), are produced. The miRNAs are important regulators of gene expression. They function mainly post-transcriptionally to control the stability or translation of their target messenger RNAs. The miRNAs are expressed in a cell-specific manner during spermatogenesis to participate in the control of each step of male germ cell differentiation. Genetically modified mouse models have demonstrated the importance of miRNA pathways for normal spermatogenesis, and functional studies have been designed to dissect the roles of specific miRNAs in distinct cell types. Clinical studies have exploited the well-defined expression profiles of miRNAs, and human spermatozoal or seminal plasma miRNAs have been explored as potential biomarkers for male factor infertility. This review article discusses the current findings that support the central role of miRNAs in the regulation of spermatogenesis and male fertility.

  16. Micro packaged MEMS pressure sensor for intracranial pressure measurement

    Science.gov (United States)

    Xiong, Liu; Yan, Yao; Jiahao, Ma; Yanhang, Zhang; Qian, Wang; Zhaohua, Zhang; Tianling, Ren

    2015-06-01

    This paper presents a micro packaged MEMS pressure sensor for intracranial pressure measurement which belongs to BioMEMS. It can be used in lumbar puncture surgery to measure intracranial pressure. Miniaturization is key for lumbar puncture surgery because the sensor must be small enough to allow it be placed in the reagent chamber of the lumbar puncture needle. The size of the sensor is decided by the size of the sensor chip and package. Our sensor chip is based on silicon piezoresistive effect and the size is 400 × 400 μm2. It is much smaller than the reported polymer intracranial pressure sensors such as liquid crystal polymer sensors. In terms of package, the traditional dual in-line package obviously could not match the size need, the minimal size of recently reported MEMS-based intracranial pressure sensors after packaging is 10 × 10 mm2. In this work, we are the first to introduce a quad flat no-lead package as the package form of piezoresistive intracranial pressure sensors, the whole size of the sensor is minimized to only 3 × 3 mm2. Considering the liquid measurement environment, the sensor is gummed and waterproof performance is tested; the sensitivity of the sensor is 0.9 × 10-2 mV/kPa. Project supported by the National Natural Science Foundation of China (Nos. 61025021, 61434001), and the ‘Thousands Talents’ Program for Pioneer Researchers and Its Innovation Team, China.

  17. A micro-epidemic model for primary dengue infection

    Science.gov (United States)

    Mishra, Arti; Gakkhar, Sunita

    2017-06-01

    In this paper, a micro-epidemic non-linear dynamical model has been proposed and analyzed for primary dengue infection. The model incorporates the effects of T cells immune response as well as humoral response during pathogenesis of dengue infection. The time delay has been accounted for production of antibodies from B cells. The basic reproduction number (R0) has been computed. Three equilibrium states are obtained. The existence and stability conditions for infection-free and ineffective cellular immune response state have been discussed. The conditions for existence of endemic state have been obtained. Further, the parametric region is obtained where system exhibits complex behavior. The threshold value of time delay has been computed which is critical for change in stability of endemic state. A threshold level for antibodies production rate has been obtained over which the infection will die out even though R0 > 1. The model is in line with the clinical observation that viral load decreases within 7-14 days from the onset of primary infection.

  18. Nanomaterials-Based Fluorimetric Methods for MicroRNAs Detection

    Directory of Open Access Journals (Sweden)

    Ming La

    2015-05-01

    Full Text Available MicroRNAs (miRNAs are small endogenous non-coding RNAs of ~22 nucleotides that play important functions in the regulation of many biological processes, including cell proliferation, differentiation, and death. Since their expression has been in close association with the development of many diseases, recently, miRNAs have been regarded as clinically important biomarkers and drug discovery targets. However, because of the short length, high sequence similarity and low abundance of miRNAs in vivo, it is difficult to realize the sensitive and selective detection of miRNAs with conventional methods. In line with the rapid development of nanotechnology, nanomaterials have attracted great attention and have been intensively studied in biological analysis due to their unique chemical, physical and size properties. In particular, fluorimetric methodologies in combination with nanotechnology are especially rapid, sensitive and efficient. The aim of this review is to provide insight into nanomaterials-based fluorimetric methods for the detection of miRNAs, including metal nanomaterials, quantum dots (QDs, graphene oxide (GO and silicon nanoparticles.

  19. Measuring In-Plane Micro-Motion of Micro-Structure Using Optical Flow

    Institute of Scientific and Technical Information of China (English)

    JIN Cuiyun; JIN Shijiu; LI Dachao; WANG Jianlin

    2009-01-01

    Optical flow method is one of the most important methods of analyzing motion images.Optical flow field is used to analyze characteristics of motion objects.According to motion features of micro-electronic mechanical system(MEMS)micro-structure,the optical algorithm based on label field and neighborhood optimization is presented to analyze the in-plane micro-motion of micro-structure.Firstly,high speed motion states for each frequency segment of micro-structure in cyclic motion are frozen based on stroboscopic principle.Thus a series of image sequences,and can obtain reliable and precise optical field and reduce computing time.As micro-resonator of urement precision of the presented algorithm is high,and measurement repeatability reaches 40 am under the same experiment condition.

  20. Design and testing of micro fluidic chemical analysis chip integrated with micro valveless pump

    Institute of Scientific and Technical Information of China (English)

    FU; Xin; XIE; Haibo; YANG; Huayong; JIA; Zhijian; FANG; Qun

    2005-01-01

    A new structure and working principle of the chip integrated with micro valveless pump for capillary electrophoresis was proposed in this paper. The micro valveless pump with plane structure has advantages of simple structure, and the process technology is compatible with existing micro chips for capillary electrophoresis. Based upon the mathematical model, simulation study of micro pump was carried out to investigate the influence of structural parameters on flow characteristics, and the performance of the integrated micro pump was also tested with different control parameters. The simulation results agree with the experimental results. Three samples, which are amino acid, fluorescein and buffer solution, have been examined with this chip. The results of the primary experiments showed that the micro valveless pump was promising in the integration and automatization of miniature integrated fluidic systems.

  1. Investigation on the micro injection molding process of an overmolded multi-material micro component

    DEFF Research Database (Denmark)

    Baruffi, Federico; Calaon, Matteo; Tosello, Guido

    2017-01-01

    Micro injection molding (μIM) is one of the few technologies capable of meeting the increasing demand of complex shaped micro plastic parts. This process, combined with the overmolding technique, allows a fast and cost-efficient production of multi-material micro components, saving numerous...... and difficult assembly steps, being the plastic molded directly on a metal substrate. In this scenario, an investigation on the fully automated micro overmolding manufacturing technology of a three-material micro component for acoustic applications has been carried out. Preliminary experiments allowed...... geometrical characteristics of the component. An optical CMM with sub-micrometric resolution has been employed for the measurements. Results show that the process parameters have a significant influence on some component features, while others mainly depend on the insert alignment inside the micro mold cavity....

  2. Challenges in high accuracy surface replication for micro optics and micro fluidics manufacture

    DEFF Research Database (Denmark)

    Tosello, Guido; Hansen, Hans Nørgaard; Calaon, Matteo;

    2014-01-01

    by replication technologies such as nickel electroplating. All replication steps are enabled by a high precision master and high reproduction fidelity to ensure that the functionalities associated with the design are transferred to the final component. Engineered surface micro structures can be either......Patterning the surface of polymer components with microstructured geometries is employed in optical and microfluidic applications. Mass fabrication of polymer micro structured products is enabled by replication technologies such as injection moulding. Micro structured tools are also produced...... distributed, e.g., to create an optical pattern, or discretised, e.g., as micro channels for fluids manipulation. Key aspects of two process chains based on replication technologies for both types of micro structures are investigated: lateral replication fidelity, dimensional control at micro scale, edge...

  3. Process Analytical Techniques Based on In-Line Vibrational Spectroscopy and their Industrial Applications

    Directory of Open Access Journals (Sweden)

    Jednačak, T.

    2013-03-01

    Full Text Available Process analytical techniques (PAT involve the monitoring and control of physical and chemical processes as well as the identification of important process parameters in order to obtain the products with desired properties. PAT have been applied in various industrial process phases to ensure better process understanding, quality by optimal design and determination of process disturbances in time. In-line vibrational spectroscopic techniques are one of the major process analytical techniques used today. The most frequently used in-line vibrational spectroscopic techniques are near infrared spectroscopy (NIR, attenuated total reflectance middle infrared spectroscopy (ATR-MIR and Raman spectroscopy (Table 1, Figs. 1 and 2. They provide in situ real-time monitoring of the production processes by using different types of in-line probes (Figs. 3–5 which reduce exposure to hazardous materials and contamination, sample degradation or equilibrium perturbations in the reaction system. Due to the aforementioned advantages, in-line vibrational spectroscopic techniques have been successfully applied for different industrial pur- poses. The analysis of characteristic vibrational bands in in-line infrared and Raman spectra enable the monitoring of different processes such as crystallization, dissolution, polimorphic transitions and chemical reactions (Scheme 1, Figs. 6 and 7. The obtained data are, due to their complexity, very often further processed by multivariate data analysis methods (Fig. 9, such as principal components analysis (PCA and partial least squares (PLS. The basic principles of PCA and PLS are shown in Fig. 8. A number of different in-line vibrational spectroscopic techniques as well as multivariate data analysis methods have been developed recently, but in this article only the most important and most frequently used techniques are described.   KUI – 7/2013 Received April 10, 2012 Accepted July 18, 2012

  4. Quantitative Evaluation Methods of In-Line X-Ray Phase Contrast Techniques

    Institute of Scientific and Technical Information of China (English)

    LI Zheng; LI Cheng-Quan; YU Ai-Min

    2007-01-01

    By revealing the relationship between edge visibility and imaging parameters in in-line phase contrast imaging (PCI), we propose a method to quantitatively measure the contribution of absorption and phase shift from acquired images. We also prove that edge visibility will grow with the increasing source-object distance and object-detector distance. The result is validated by relative phase factor and by experiments conducted on a microfocus x-ray source. This method provides a new approach to evaluate in-line PCI images and is helpful for deciding imaging parameters.

  5. Comparison of an Inductance In-Line Oil Debris Sensor and Magnetic Plug Oil Debris Sensor

    Science.gov (United States)

    Dempsey, Paula J.; Tuck, Roger; Showalter, Stephen

    2012-01-01

    The objective of this research was to compare the performance of an inductance in-line oil debris sensor and magnetic plug oil debris sensor when detecting transmission component health in the same system under the same operating conditions. Both sensors were installed in series in the NASA Glenn Spiral Bevel Gear Fatigue Rig during tests performed on 5 gear sets (pinion/gear) when different levels of damage occurred on the gear teeth. Results of this analysis found both the inductance in-line oil debris sensor and magnetic plug oil debris sensor have benefits and limitations when detecting gearbox component damage.

  6. Microenvironment Tracker (MicroTrac) Factsheet

    Science.gov (United States)

    MicroTrac is a model developed by EPA that uses GPS data to estimate time of day and duration that people spend in different microenvironments, such as indoors and outdoors at home, work, school, and inside vehicles.

  7. EO Scanned Micro-LADAR Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this phase II SBIR we will design, build, test, and deliver new scanning based micro-ladar sensors with unprecedented small size, weight, and power (SWaP),...

  8. Evaluation of the micro-carburetor

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, M.F.; Hall, R.A.; Mazor, S.D.

    1981-08-01

    A prototype sonic, variable-venturi automotive carburetor, developed by Micro Carburetor Corporation, was evaluated for its effects on vehicle performance, fuel economy, and exhaust emissions. A 350 CID Chevrolet Impala vehicle was tested on a chassis dynamometer over the 1975 Federal Test Procedure, urban driving cycle. The Micro-carburetor was tested and compared with stock and modified-stock engine configurations. Subsequently, the test vehicle's performance characteristics were examined with the stock carburetor and again with the Micro-carburetor in a series of on-road driveability tests. The test engine was then removed from the vehicle and installed on an engine dynamometer. Engine tests were conducted to compare the fuel economy, thermal efficiency, and cylinder-to-cylinder mixture distribution of the Micro-carburetor to that of the stock configuration. Test results show increases in thermal efficiency and improvements in fuel economy at all test conditions.

  9. Micro Learning: A Modernized Education System

    Directory of Open Access Journals (Sweden)

    Omer Jomah

    2016-03-01

    Full Text Available Learning is an understanding of how the human brain is wired to learning rather than to an approach or a system. It is one of the best and most frequent approaches for the 21st century learners. Micro learning is more interesting due to its way of teaching and learning the content in a small, very specific burst. Here the learners decide what and when to learn. Content, time, curriculum, form, process, mediality, and learning type are the dimensions of micro learning. Our paper will discuss about micro learning and about the micro-content management system. The study will reflect the views of different users, and will analyze the collected data. Finally, it will be concluded with its pros and cons. 

  10. EO Scanned Micro-LADAR Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this SBIR program we will develop, design and build new scanning based micro-ladar sensors with unprecedented small size, weight, and power (SWaP), thereby...

  11. Micro Resistojet for Small Satellites Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Micro-resistojets offer the best combination of simplicity, performance, wet system mass and power consumption for small satellites (<100kg, <50Watts)...

  12. Micro Resistojet for Small Satellites Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Micro-resistojets offer an excellent combination of simplicity, performance and wet system mass for small satellites (<100 kg, <50 watts) requiring mN level...

  13. GEOMETRICAL CHARACTERIZATION OF MICRO END MILLING TOOLS

    DEFF Research Database (Denmark)

    Borsetto, Francesca; Bariani, Paolo

    for the manufacturing of miniature parts by micro milling puts further challenges on to the manufacturing process. The whole geometry of the tools cannot be directly downscaled with the tool diameter. Besides the physical limit in the reduction of the cutting edge radius constituted by the grain size of sintered...... carbides the error motion during the grinding wheels do not allow using identical paths for tools having differences in diameter of more than one order of magnitude. Thus grinding paths for micro and mills are simplified in comparison to those for larger tools of similar shape. [1] The aim of the present...... report is to develop procedures for the geometrical characterization of micro end milling tools in order to define a method suitable for the quality assurance in the micro cutting field....

  14. Characterization system for resonant micro- and nanocantilevers

    DEFF Research Database (Denmark)

    Sandberg, Rasmus Kousholt; Boisen, Anja; Svendsen, Winnie Edith

    2005-01-01

    We present a system for characterization of the resonant properties of micro- and nanocantilever sensors. The system has been constructed as a vacuum chamber with capabilities for controlling environmental conditions such as pressure, temperature, and chemical constituents. Characterization can...

  15. Laser micro-impulse torsion pendulum

    Institute of Scientific and Technical Information of China (English)

    Jing Li; Zhiping Tang

    2005-01-01

    @@ In order to investigate the feasibility regarding micro-satellite posture steering by laser micro-propulsion, a laser torsion pendulum has been set up so as to get first-hand basic physical and mechanical parameters on laser micro-propulsion. The instrumentation consists of the optical, mechanical, and electrical sub-systems.The optical system includes the main beam optics, the measuring optics, and the observation optics. The mechanical system includes the gyration apparatus, transverse translation stage, vertical translator, focal lenses translator, calibration pendulum translator, and vacuum chamber. For the electrical system a computer is used to control stepping motors to drive the above moving apparatuses. With this instrument the calibration experiment and laser ablation experiment have been carried out. The experimental results about 10.4%, which can satisfy the requirement of micro-impulse measurement.

  16. High range resolution micro-Doppler analysis

    Science.gov (United States)

    Cammenga, Zachary A.; Smith, Graeme E.; Baker, Christopher J.

    2015-05-01

    This paper addresses use of the micro-Doppler effect and the use of high range-resolution profiles to observe complex targets in complex target scenes. The combination of micro-Doppler and high range-resolution provides the ability to separate the motion of complex targets from one another. This ability leads to the differentiation of targets based on their micro-Doppler signatures. Without the high-range resolution, this would not be possible because the individual signatures would not be separable. This paper also addresses the use of the micro-Doppler information and high range-resolution profiles to generate an approximation of the scattering properties of a complex target. This approximation gives insight into the structure of the complex target and, critically, is created without using a pre-determined target model.

  17. Small Antennas for Wireless Micro-Systems

    OpenAIRE

    Rainer Wansch

    2002-01-01

    This paper will describe the topology of wireless micro-systems networks and some of their key components. In particular we will deal with the antennas: loops, helices, F-antennas, patches and dielectrically loaded antennas.

  18. Micro Learning: A Modernized Education System

    Directory of Open Access Journals (Sweden)

    Omer Jomah

    2016-03-01

    Full Text Available Learning is an understanding of how the human brain is wired to learning rather than to an approach or a system. It is one of the best and most frequent approaches for the 21st century learners. Micro learning is more interesting due to its way of teaching and learning the content in a small, very specific burst. Here the learners decide what and when to learn. Content, time, curriculum, form, process, mediality, and learning type are the dimensions of micro learning. Our paper will discuss about micro learning and about the micro-content management system. The study will reflect the views of different users, and will analyze the collected data. Finally, it will be concluded with its pros and cons. 

  19. Micro-polymer Chemistry Experiment Teaching Research

    Institute of Scientific and Technical Information of China (English)

    李青山

    2009-01-01

    For nearly thirty years,there has been made great progress in micro-polymer chemistry experiment teaching which has these characteristics that using less reagents,less pollution and more portable in comparison with the conventional experiment.In China,Zhou Ninghuai and others began to go on micro-scale experiment research firstly and Professor Li Qingshan who brought this innovation to polymer organic synthesis experiment has done a lot of works in micro-polymer chemistry experiment teaching.To carry out the study ofmicro-polymer chemistry experiments not only accords with teaching methods and reform,but also conforms to the trend of the times of green chemistry.So the research and application of micro-polymer chemistry experiment have broad prospects.

  20. Passive ring resonator micro-optical gyroscopes

    Science.gov (United States)

    Venediktov, V. Yu; Filatov, Yu V.; Shalymov, E. V.

    2016-05-01

    This paper reviews recent advances in passive micro-optical gyroscopes. In the last decade, most research effort in the area of micro-optical gyros has been concentrated on a configuration that takes advantage of a single-mode passive ring resonator, which is usually fabricated using integrated optical technologies. The dimensions of such micro-optical gyros are comparable to those of micromechanical gyroscopes (area of 10 to 100 mm2) and their sensitivity is considerably better than the sensitivity of the latter, approaching that of fibre-optic and laser gyros. Moreover, microoptical gyros can be made as a single integrated circuit, like the micromechanical gyros, but they have no movable parts, in contrast to their micromechanical counterparts. We also describe the development and investigation of micro-optical gyros produced in our studies.

  1. Simple Signal Source based Micro Controller

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Using micro controller, DAC and Multi-periods syn-thesis, we can buildup a very simple signal source with precisefrequency, amplitude and waveform. Wave parameters can beprogrammed in advance. The circuit can satisfy some special re-quirements.

  2. Micro Mercury Ion Clock (MMIC) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Demonstrate micro clock based on trapped Hg ions with more than 10x size reduction and power; Fractional frequency stability at parts per 1014 level, adequate for...

  3. MicroCar 2003. Abstracts of papers

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    Mechatronics for automotive applications is an important trend, combining mechanics, electronics and information technology. Micro- and nanomechatronics, particularly innovative research disciplines, will help create, in combination with advanced solutions from microsystem technologies, e.g. the electronic packaging, a range of entirely new developments in automobiles. Under the umbrella of the Automotive Suppliers Fair Z2003, it is happening for the very first time now that a momentous scientific conference, such as the MicroCar 2003, brings together representatives from car manufacturers and the electronics industry, as well as a large number of experts from technical colleges, universities and research institutes to discuss the new potentials and possibilities presented by the use of micro and nanomaterials in Leipzig. With the presentation of 50 papers, speakers will inform about their latest research results as well as current trends in micro and nanotechnologies for automotives. This issue is publishing the abstracts of this scientific event.

  4. Fabrication of micro-lens array on convex surface by meaning of micro-milling

    Science.gov (United States)

    Zhang, Peng; Du, Yunlong; Wang, Bo; Shan, Debin

    2014-08-01

    In order to develop the application of the micro-milling technology, and to fabricate ultra-precision optical surface with complex microstructure, in this paper, the primary experimental research on micro-milling complex microstructure array is carried out. A complex microstructure array surface with vary parameters is designed, and the mathematic model of the surface is set up and simulated. For the fabrication of the designed microstructure array surface, a micro three-axis ultra-precision milling machine tool is developed, aerostatic guideway drove directly by linear motor is adopted in order to guarantee the enough stiffness of the machine, and novel numerical control strategy with linear encoders of 5nm resolution used as the feedback of the control system is employed to ensure the extremely high motion control accuracy. With the help of CAD/CAM technology, convex micro lens array on convex spherical surface with different scales on material of polyvinyl chloride (PVC) and pure copper is fabricated using micro tungsten carbide ball end milling tool based on the ultra-precision micro-milling machine. Excellent nanometer-level micro-movement performance of the axis is proved by motion control experiment. The fabrication is nearly as the same as the design, the characteristic scale of the microstructure is less than 200μm and the accuracy is better than 1μm. It prove that ultra-precision micro-milling technology based on micro ultra-precision machine tool is a suitable and optional method for micro manufacture of microstructure array surface on different kinds of materials, and with the development of micro milling cutter, ultraprecision micro-milling complex microstructure surface will be achieved in future.

  5. Concept Studies of Micro-Pump for Chemical Concentration in Handheld Micro Sensors

    Science.gov (United States)

    2007-11-02

    This report summarizes the preliminary results of a short-term innovative research project on the concept study of micro pumps for chemical...main objective of the work is to study the feasibility of certain micro pumping concepts and their potential integration with the sensing material and... micro pumps is demonstrated, although the quantitative assessment of the pumping system is still elusive, partly because of lack of specifications. The

  6. Micro Loudspeaker Behaviour versus 6½" Driver, Micro Loudspeaker Parameter Drift

    DEFF Research Database (Denmark)

    Pedersen, Bo Rohde

    2010-01-01

    This study tested micro loudspeaker behavior from the perspective of loudspeaker parameter drift. The main difference between traditional transducers and micro loudspeakers, apart from their size, is their suspension construction. The suspension generally is a loudspeaker's most unstable parameter......, and the study investigated temperature drift and signal dependency. There is investigated three different micro loudspeakers and compared their behavior to that of a typical bass mid-range loudspeaker unit. There is measured all linear loudspeaker parameters at different temperatures....

  7. Micro Loudspeaker Behaviour versus 6½" Driver, Micro Loudspeaker Parameter Drift

    DEFF Research Database (Denmark)

    Pedersen, Bo Rohde

    2010-01-01

    This study tested micro loudspeaker behavior from the perspective of loudspeaker parameter drift. The main difference between traditional transducers and micro loudspeakers, apart from their size, is their suspension construction. The suspension generally is a loudspeaker's most unstable parameter......, and the study investigated temperature drift and signal dependency. There is investigated three different micro loudspeakers and compared their behavior to that of a typical bass mid-range loudspeaker unit. There is measured all linear loudspeaker parameters at different temperatures....

  8. Micro Electro Mechanical Systems (MEMS) Micro-Switches for Use in DC, RF, and Optical Applications

    Science.gov (United States)

    Suzuki, Kenichiro

    2002-06-01

    Micromachined micro-switches have stimulated the development of the core infrastructure technology for the next generation communication systems because of their superior performance. They are fabricated by similar silicon micromachined processes, but the switch structure and its characteristics depend on each application. Micro electro mechanical systems (MEMS) technology has been applied to micro relays, RF switches, and optical switches; as a result, optical and mechanical performance has been improved.

  9. microRNA研究进展%Progresses on the microRNA study

    Institute of Scientific and Technical Information of China (English)

    华友佳; 肖华胜

    2005-01-01

    小分子RNA家族中的一员--microRNA,是一段非常短的非编码RNA序列,对多种生物学过程起调控作用.本文试从microRNA的结构特点、合成及作用机制和功能等方面对microRNA的研究进展作一个简单回顾.

  10. MicroEnterprise Americas: Premiere Issue, 2001

    OpenAIRE

    Inter-American Development Bank (IDB)

    2001-01-01

    This premiere issue of MicroEnterprise Americas concentrates on the microfinance industry, a thriving segment of the Latin American financial sector that has rapidly expanded in the past five years. This issue explores looks at how market leaders have developed technologies, attracted investments, and developed tools for mitigating risk in the difficult financial climate of the past two years. MicroEnterprise Americas is published by the Inter-American Forum on Microenterprise, an annual even...

  11. Alkaliphilic Micro-organisms and Habitats

    OpenAIRE

    Ulukanli, Zeynep

    2002-01-01

    Alkaline environments are typical extreme environments which include naturally occurring soda lakes, deserts, soils and artificially occurring industrial-derived waters. Micro-organisms that occupy extreme pH environments have resulted in the definition of an unusual group, termed alkaliphiles. In this review, the current status of the biodiversity of alkaliphilic micro-organisms in various environments and aspects of their biotechnological potential are summarised briefly.

  12. MicroEnterprise Americas: Premiere Issue, 2001

    OpenAIRE

    Inter-American Development Bank (IDB)

    2001-01-01

    This premiere issue of MicroEnterprise Americas concentrates on the microfinance industry, a thriving segment of the Latin American financial sector that has rapidly expanded in the past five years. This issue explores looks at how market leaders have developed technologies, attracted investments, and developed tools for mitigating risk in the difficult financial climate of the past two years. MicroEnterprise Americas is published by the Inter-American Forum on Microenterprise, an annual even...

  13. Method for obtaining solid micro -or nanoparticles

    OpenAIRE

    Ventosa Rull, Nora; Veciana Miró, Jaume; Cano-Sarabia, Mary; Sala Vergés, Santiago

    2008-01-01

    [EN] The invention provides a novel method for obtaining solid micro -or nanoparticIes with a homogeneous structure. A method is provided for obtaining solid micro -or nanoparticIes with a homogeneous structure having a particIe size of less than 10 /lm where the processed solid compound has the natural, crystalline, amorphous, polymorphic and other features associated with the starting compound. In accordance with the invention a method which also makes it possible to obtain solid m...

  14. Embedded Operating System for MicroBlaze

    OpenAIRE

    2006-01-01

    This paper presents a work in progress on experiments with embedded operating systems for the MicroBlaze processor. Modern embedded systems based on a configurable platform incorporating a similar processor core are gaining importance with the ongoing effort to minimize cost and development time. After an overview of the configurable platform based on this processor core, we devote our attention to uClinux OS. This OS has been successfully ported for the MicroBlaze processor, and we present o...

  15. Micro PEM Fuel Cells and Stacks

    Institute of Scientific and Technical Information of China (English)

    Shou-shing; Hsieh

    2007-01-01

    1 Results The effects of different operating parameters on micro proton exchange membrane (PEM) fuel cell performance were experimentally studied for three different flow field configurations (interdigitated,mesh,and serpentine).Experiments with different cell operating temperatures and different backpressures on the H2 flow channels,as well as various combinations of these parameters,have been conducted for three different flow geometries.The micro PEM fuel cells were designed and fabricated in-house t...

  16. Experimental Research on Micro-nozzle Applied on Micro-propulsion Systems based on MEMS

    Science.gov (United States)

    Bao-jun, Zhang; Xing-chen, Li; Yi-yong, Huang; Xiang-ming, Xu

    2017-03-01

    In order to study the influence of the structural parameters of micro thruster applied in micro satellite attitude adjustment and orbital maneuver on its propulsion performance, this paper considers the factors influencing the performance of the thruster, and utilizes the orthogonal test design to obtain nine groups of micro-nozzles with different structural parameters. We processed this series of micro nozzles through MEMS (Micro-Electro-Mechanical Systems) technology. The micro-nozzles are made of single crystal silicon and glass through the anode bonding, and the electric heating wire is creatively processed through MEMS in the thrust chamber to improve the performance of the micro thruster. Experiments were carried out in a vacuum chamber. Finally, we analyse the experimental results by analysis of variance and analysis of range. The experimental results show that the performance of the micro nozzle is optimal when the semi-shrinking angle is 30 degrees, the semi-expansion angle is 15 degrees and the area ratio is 6.22. Meantime, the experiment verifies that it is feasible to improve the propulsive performance of micro-propulsion system through electronic heater strip.

  17. Analysis of bistable inductive micro-switch based on surface micro size effect

    Science.gov (United States)

    Tian, Wenchao; Chen, Zhiqiang

    2015-04-01

    The inductive micro-switch can not only induce an external acceleration, but also be controlled by the external acceleration to realize a trigger action. It is an integrative device of a sensor and an actuator. However, little work has been done to develop a comprehensive model to accurately analyze the micro size effect during micro-switch contact process. So its malfunctions related to "fail-to-closure" and "transient-closure" result in low reliability and weak anti-jamming capability. A bistable inductive micro-switch is presented based on nano electro-mechanical system (NEMS) technology and micro size effect. And the sine-model is used to describe the rough contact surface of the micro-switch. Micro size forces such as the Casimir force and van der Waals (vdW) force are analyzed in detail using the principles of vacuum energy and the Wigner-Seitz micro-continuum media. The vdW force includes the repulsive force. The simulation results of the Casimir force varied with the gap are obtained, which is compared with the relative experimental result. The dynamic equation of the bistable inductive micro-switch is established. Dynamic simulation results are shown to be in agreement with experimental results. The threshold acceleration is 6.8 g, and the response time is 17.5 μs.

  18. Micro powder injection molding-large scale production technology for micro-sized components

    Institute of Scientific and Technical Information of China (English)

    YIN HaiQing; JIA ChengChang; QU XuanHui

    2008-01-01

    Micro powder injection molding (μPIM), a miniaturized variant of powder injection molding, has advantages of shape complexity, applicability to many materials and good mechanical properties. Co-injection molding has been realized between metals and ceramics on micro components, which become the first breakthrough within the PIM field. Combined with the prominent characteristics of high features/cost ratio, micro powder injection molding becomes a potential technique for large scale production of intricate and three-dimensional micro components or microstructured components in microsystems technology (MST) field.

  19. microRNA与肿瘤转移%MicroRNAs and neoplasm metastasis

    Institute of Scientific and Technical Information of China (English)

    田伊茗; 王爽; 丁彦青

    2009-01-01

    MicroRNA,known as micro-RNA or miRNA,is a cluster of endogenous non-coding small RNAs regulating protein-coding mRNAs at the post-transcriptional level. More and more studies confirm the important role of microRNA in tumor metastasis,and the research of tumor metastasis-related microRNA has be-come the focus of attention. MicroRNAs may bring breakthroughs on diagnosis and treatment of tumor metasta-sis.%微RNA(microRNA)又称微小RNA、miRNA,是在转录后水平对编码蛋白质的mRNA进行调控的一族内源性非编码小RNA.越来越多的研究结果证实microRNA在肿瘤转移过程中发挥重要作用,肿瘤转移相关microRNA的研究已成为关注的热点.microRNA可能给肿瘤转移的诊断与治疗带来新的突破.

  20. Advances in MicroRNAs Research%MicroRNAs研究进展

    Institute of Scientific and Technical Information of China (English)

    丁伟超; 陈永康; 王莹

    2012-01-01

    MicroRNAs(miRNAs) are small regulator.noncoding RNA molecules that are transcribed as primary microR-NAs (pri-microRNAs) from eukaryotic genomes,prokaryotic genomes and virus,involved in post-transcriptional and transla-tional control of gene expression,either via degradation or translational inhibition of target mRNAs. These microRNAs play central roles in a wide range of biological processes,including cell proliferation,differentiation and apoptosis. This review has outlined the characteristics,process of maturation,mechanism of action and their function.%MicroRNAs简称miRNAs(微小RNAs),是真核生物、原核生物以及病毒中由非编码蛋白基因转录成的初级前体microRNAs加工成的调控因子.在转录后水平和蛋白质翻译水平,microRNAs通过降解或翻译抑制调控靶mRNA.这些microRNAs在广泛的生物过程中发挥重要作用,包括细胞增殖,分化和凋亡.主要介绍microR-NAs的特征,加工与成熟过程,作用机制以及其功能.

  1. Modulation of microRNA activity by semi-microRNAs (smiRNAs

    Directory of Open Access Journals (Sweden)

    Isabelle ePlante

    2012-06-01

    Full Text Available The ribonuclease Dicer plays a central role in the microRNA pathway by catalyzing the formation of 19 to 24-nucleotide (nt long microRNAs. Subsequently incorporated into Ago2 effector complexes, microRNAs are known to regulate messenger RNA (mRNA translation. Whether shorter RNA species derived from microRNAs exist and play a role in mRNA regulation remains unknown. Here, we report the serendipitous discovery of a 12-nt long RNA species corresponding to the 5’ region of the microRNA let-7, and tentatively termed semi-microRNA, or smiRNA. Using a smiRNA derived from the precursor of miR-223 as a model, we show that 12-nt long smiRNA species are devoid of any direct mRNA regulatory activity, as assessed in a reporter gene activity assay in transfected cultured human cells. However, smiR-223 was found to modulate the ability of the microRNA from which it derives to mediate translational repression or cleavage of reporter mRNAs. Our findings suggest that smiRNAs may be generated along the microRNA pathway and participate to the control of gene expression by regulating the activity of the related full-length mature microRNA in vivo.

  2. MicroRNA Regulation in Renal Pathophysiology

    Directory of Open Access Journals (Sweden)

    Jianghui Hou

    2013-06-01

    Full Text Available MicroRNAs are small, noncoding RNA molecules that regulate a considerable amount of human genes on the post-transcriptional level, and participate in many key biological processes. MicroRNA deregulation has been found associated with major kidney diseases. Here, we summarize current knowledge on the role of microRNAs in renal glomerular and tubular pathologies, with emphasis on the mesangial cell and podocyte dysfunction in diabetic nephropathy, the proximal tubular cell survival in acute kidney injury, the transport function of the thick ascending limb in Ca++ imbalance diseases, and the regulation of salt, K+ and blood pressure in the distal tubules. Identification of microRNAs and their target genes provides novel therapeutic candidates for treating these diseases. Manipulation of microRNA function with its sense or antisense oligonucleotide enables coordinated regulation of the entire downstream gene network, which has effectively ameliorated several renal disease phenotypes. The therapeutic potentials of microRNA based treatments, though promising, are confounded by major safety issues related to its target specificity, which remain to be fully elucidated.

  3. Micro-Ramps for Hypersonic Flow Control

    Directory of Open Access Journals (Sweden)

    Konstantinos Kontis

    2012-04-01

    Full Text Available Shock/boundary layer interaction (SBLI is an undesirable phenomenon, occurring in high-speed propulsion systems. The conventional method to manipulate and control SBLI is using a bleed system that involves the removal of a certain amount of mass of the inlet flow to control boundary layer separation. However, the system requires a larger nacelle to compensate the mass loss, larger nacelles contribute to additional weight and drag and reduce the overall performance. This study investigates a novel type of flow control device called micro-ramps, a part of the micro vortex generators (VGs family that intends to replace the bleed technique. Micro-ramps produce pairs of counter-rotating streamwise vortices, which help to suppress SBLI and reduce the chances of flow separation. Experiments were done at Mach 5 with two micro-ramp models of different sizes. Schlieren photography, surface flow visualization and infrared thermography were used in this investigation. The results revealed the detailed flow characteristics of the micro-ramp, such as the primary and secondary vortices. This helps us to understand the overall flow physics of micro-ramps in hypersonic flow and their application for SBLI control.

  4. Laser 3D micro-manufacturing

    Science.gov (United States)

    Piqué, Alberto; Auyeung, Raymond C. Y.; Kim, Heungsoo; Charipar, Nicholas A.; Mathews, Scott A.

    2016-06-01

    Laser-based materials processing techniques are gaining widespread use in micro-manufacturing applications. The use of laser microfabrication techniques enables the processing of micro- and nanostructures from a wide range of materials and geometries without the need for masking and etching steps commonly associated with photolithography. This review aims to describe the broad applications space covered by laser-based micro- and nanoprocessing techniques and the benefits offered by the use of lasers in micro-manufacturing processes. Given their non-lithographic nature, these processes are also referred to as laser direct-write and constitute some of the earliest demonstrations of 3D printing or additive manufacturing at the microscale. As this review will show, the use of lasers enables precise control of the various types of processing steps—from subtractive to additive—over a wide range of scales with an extensive materials palette. Overall, laser-based direct-write techniques offer multiple modes of operation including the removal (via ablative processes) and addition (via photopolymerization or printing) of most classes of materials using the same equipment in many cases. The versatility provided by these multi-function, multi-material and multi-scale laser micro-manufacturing processes cannot be matched by photolithography nor with other direct-write microfabrication techniques and offer unique opportunities for current and future 3D micro-manufacturing applications.

  5. Homogenization in micro-magneto-mechanics

    Science.gov (United States)

    Sridhar, A.; Keip, M.-A.; Miehe, C.

    2016-07-01

    Ferromagnetic materials are characterized by a heterogeneous micro-structure that can be altered by external magnetic and mechanical stimuli. The understanding and the description of the micro-structure evolution is of particular importance for the design and the analysis of smart materials with magneto-mechanical coupling. The macroscopic response of the material results from complex magneto-mechanical interactions occurring on smaller length scales, which are driven by magnetization reorientation and associated magnetic domain wall motions. The aim of this work is to directly base the description of the macroscopic magneto-mechanical material behavior on the micro-magnetic domain evolution. This will be realized by the incorporation of a ferromagnetic phase-field formulation into a macroscopic Boltzmann continuum by the use of computational homogenization. The transition conditions between the two scales are obtained via rigorous exploitation of rate-type and incremental variational principles, which incorporate an extended version of the classical Hill-Mandel macro-homogeneity condition covering the phase field on the micro-scale. An efficient two-scale computational scenario is developed based on an operator splitting scheme that includes a predictor for the magnetization on the micro-scale. Two- and three-dimensional numerical simulations demonstrate the performance of the method. They investigate micro-magnetic domain evolution driven by macroscopic fields as well as the associated overall hysteretic response of ferromagnetic solids.

  6. Advanced Micro Turbine System (AMTS) -C200 Micro Turbine -Ultra-Low Emissions Micro Turbine

    Energy Technology Data Exchange (ETDEWEB)

    Capstone Turbine Corporation

    2007-12-31

    In September 2000 Capstone Turbine Corporation commenced work on a US Department of Energy contract to develop and improve advanced microturbines for power generation with high electrical efficiency and reduced pollutants. The Advanced MicroTurbine System (AMTS) program focused on: (1) The development and implementation of technology for a 200 kWe scale high efficiency microturbine system (2) The development and implementation of a 65 kWe microturbine which meets California Air Resources Board (CARB) emissions standards effective in 2007. Both of these objectives were achieved in the course of the AMTS program. At its conclusion prototype C200 Microturbines had been designed, assembled and successfully completed field demonstration. C65 Microturbines operating on natural, digester and landfill gas were also developed and successfully tested to demonstrate compliance with CARB 2007 Fossil Fuel Emissions Standards for NOx, CO and VOC emissions. The C65 Microturbine subsequently received approval from CARB under Executive Order DG-018 and was approved for sale in California. The United Technologies Research Center worked in parallel to successfully execute a RD&D program to demonstrate the viability of a low emissions AMS which integrated a high-performing microturbine with Organic Rankine Cycle systems. These results are documented in AMS Final Report DOE/CH/11060-1 dated March 26, 2007.

  7. Micro-Doppler classification of riders and riderless horses

    Science.gov (United States)

    Tahmoush, David

    2014-05-01

    Micro-range Micro-Doppler can be used to isolate particular parts of the radar signature, and in this case we demonstrate the differences in the signature between a walking horse versus a walking horse with a rider. Using micro-range micro-Doppler, we can distinguish the radar returns from the rider as separate from the radar returns of the horse.

  8. Development of Compressor for Ultra Micro Gas Turbine

    Institute of Scientific and Technical Information of China (English)

    Shimpei MIZUKI

    2007-01-01

    The major problems for the development of an ultra micro gas turbine system were discussed briefly from the stand point of the internal flow and the performance characteristics. Following to these, the development of ultra micro centrifugal compression systems for the ultra micro gas turbine is explained with the design and the manufacturing processes. The measured results of ultra micro centrifugal compressors are shown.

  9. Micro mechanical study of shales

    Science.gov (United States)

    Bonnelye, Audrey; Picard, David; Gharbi, Hakim; Dimanov, Alexandre; Bornert, Michel; Conil, Nathalie

    2017-04-01

    In the following years, the French nuclear wastes will be buried in the underground repository in shales, that will be excavated at 490 m in depth, within the Callovo Oxfordian (Cox) argillaceous formation. The hydro-mechanical behavior of the argillaceous rock is complex, like the multiphase and multi-scale structured material itself. The argilaceous matrix is composed of interstratified Illite-Smectite particles, it contains detritic quartz and calcite, accessory pyrite, and the rock porosity ranges from micrometre to nanometre scales. Besides the bedding anisotropy, structural variabilities exist at all scales, from the decametric-metric scales of the geological formation to the respectively millimetric and micrometric scales of the aggregates of particles and clay particles Our study aims at understanding the complex mechanisms which are activated at the micro-scale and are involved in the macroscopic inelastic deformation of such a complex material.An experimental protocol was developed in order to perform uniaxial deformation experiment at controlled displacement rate, inside an environmental scanning electron microscope (ESEM), under controlled relative humidity, in order to preserve as much as possible the natural state of saturation of shales. Three sample orientations (90°, 45° and 0°) were used in order to characterize the mechanical anisotropy and the mechanisms involved in the deformation. The observed smple surfaces were polished by broad ion beam in order to reveal the fine microstructures of the argillaceous matrix. Digital images were acquired at different loading stages during the deformation process and Digital Image Correlation Technique (DIC) was applied in order to retrieve full strain fields at various scales from sample scale to microstructure scale. The analysis allows for identification of the active mechanisms, their relationships to the microstructure and their interactions.

  10. Intraoral micro-identification discs.

    Science.gov (United States)

    Hansen, R W

    1991-12-01

    Intraoral micro-identification discs have recently been utilized to provide a more permanent method of personal identification. A wafer of plastic or metal with a surface area of 2.5 to 5 mm2 and carrying identifying numbers and/or letters (indicia) is bonded to the buccal enamel surface of the posterior teeth. Personal identification can occur after the I.D. disc is identified and the indicia is read. Reading of photoreduced indicia requires the aid of a microscope subsequent to the removal of the microdisc. In situ reading of disc indicia is possible using low power handheld magnifiers if the size of the indicia approximates 0.3 mm. Computerization is an integral part of non-custom alpha/numeric type designs, but a custom disc carries a name, address, and other specific information unique to the manufacturer. The use of a computer improves access to the database and it decreases the amount of data placed on the disc. Microdisc bases may be fabricated using a mylar type plastic or they may be manufactured from a stainless steel blank. Plastic discs are constructed with an internal sandwich containing the photo-reduced indicia. Metal discs are marked with a photochemical etch or engraved with a computer driven YAG laser. Attachment of the disc to the enamel surface is accomplished by conventional etching and bonding techniques and are typically bonded to the buccal surface of the maxillary first permanent molar or the second primary molar. Clear composite bonding material covers the disc so that salivary contamination does not result in degradation of the indicia. Orthodontic style discs with a mesh back carry laser written information that may be cemented with conventional orthodontic bonding cement. Standardization of the indicia and overall design is considered to be an important aspect of patient and professional acceptance.

  11. Micro-Layer Tomography System

    Directory of Open Access Journals (Sweden)

    M. Navabpour

    2005-08-01

    Full Text Available Introduction & Background: Tomography or plani-graphy is an x-ray imaging system for preserving a certain plane of a radiography object by diffusing the other planes; however, the desired plane does not obtain an optimum sharpness. Meanwhile, relatively nearer points to the rotating axes fixed point have lesser liner velocity than those lying further from the fixed point. Consequently, unwanted obscuring planes occur gradually, that then render the wanted plane somehow blurred, hence the phenomenon known as "tomographic blurring", which diminishes the clinical value of the image. Thus, computerized imaging is uncertain especially to medical authorities. Besides, there is a possibility of dismissing the lesion in some cases, because of the relatively undesirable deep resolution of the system. The present innovation could be an approach to improve current tomography systems by increasing image resolution, obtaining optimum deep resolution, rapid operation, and cost reduction. Material and Methods: Micro-layer tomography has been designed with the benefit of fast x-ray rotating velocity without tube movement, to make images with deep resolution of millimeter fraction, while there is no need of digital images reconstruction in-struments that allows statistical errors to fall to about zero. Furthermore, high-resolution images could be prepared in all planes, including coronal, sagittal, and transverse ones. Likewise, patient treatment and sys-tem maintenance costs are by far less than those in CT scan and MRI. Results & Conclusion: The system quick operation is highly exceptional; therefore, the tomographic slices could be prepared in about less than 0.02 second. The laboratory samples experienced by this system showed a unique result, suggesting the new device preference.

  12. Fs-laser micro machining for μ-TLM resistivity test structures in photovoltaic TCO multilayers

    Science.gov (United States)

    Krause, Stephan; Kaufmann, Kai; Lancaster, Kevin; Naumann, Volker; Großer, Stephan; Hagendorf, Christian

    2016-04-01

    In this work we developed a new approach for resistivity measurements based on fs laser micro machining of μ-TLM test structures. This method is applied to highly resistive interfacial and conductive bulk multilayer systems in photovoltaic TCO thin film devices. Resistivity data has been acquired by a new TLM based method at μm-dimensions (μ-TLM, patent pending, DE 102014211352.0). For this approach, isolating trenches are prepared in the µm range with reasonable effort using fs laser processing. The application of ultrashort pulses with a laser wavelength in the IR range (λ = 1.03 μm) allows selective removal of the top SnO2 layer of the TCO multilayer stack by a reduced thermal influence on the layers beneath and in the adjacent region of the laser trenches. Small effective optical penetration and ablation depth was achieved by an ultrafast thermal ablation mechanism via free carrier absorption at the interface of the SnO2/ITO layers. Therefore the risk of laser induced modification of the electric layer properties is negligible. The μ-TLM test structure results in highly accurate and reproducible resistivity data. Applied to SnO2/ITO/glass double layer stacks, the obtained resistivity values for the SnO2 interfacial layer (ρTO = 40.5 kΩμm) and for the indium tin oxide thin film (ρITO = 1.3 Ωμm) agree with reference data from four-point-probing and from literature.

  13. In-line holography for flow and cavitation visualization on hydrofoils and for nuclei measurements

    OpenAIRE

    Renesse, R.L. van; Meulen, J.H.J. van der

    1980-01-01

    The boundary layer flow about two hydrofoils and the appearance of cavitation are investigated by means of in-line holography. Practical details on the hologram resolution and data collection time for nuclei size analysis are given. It is shown that the appearance of cavitation on the hydrofoils is strongly influenced by viscous effects.

  14. First in Line Waiting Times as a Tool for Analysing Queueing Systems

    DEFF Research Database (Denmark)

    Koole, G. M.; Nielsen, Bo Friis; Nielsen, Thomas Bang

    2012-01-01

    We introduce a new approach to modelling queueing systems where the priority or the routing of customers depends on the time the first customer has waited in the queue. This past waiting time of the first customer in line, WFIL, is used as the primary variable for our approach. A Markov chain is ...

  15. Development of a control system for in-line coagulation in an ultrafiltration process

    NARCIS (Netherlands)

    Blankert, Bastiaan; Betlem, Ben H. L.; Roffel, Brian

    2007-01-01

    A control system for the in-line coagulation applied in an ultrafiltration process was developed. The dosing strategy aims to apply a minimal coagulant dose while maintaining desirable process performance by regulating the initial filtration resistance. This is achieved by a feedback controller. It

  16. In-Line Oil-Water Separation in Swirling Flow (USB stick)

    NARCIS (Netherlands)

    Slot, J.J.; van Campen, L.J.A.M.; Hoeijmakers, Hendrik Willem Marie; Mudde, R.F.; Johansen, S.T.

    2011-01-01

    An in-line oil-water separator has been designed and is investigated for single- and two-phase flow. Numerical single-phase flow results show an annular reversed flow region. This flow pattern agrees qualitatively with results from measurements. In the two-phase flow simulations two different drag

  17. Three-dimensional Effects of Turburlent Flow in an In-Line Tube Bundle

    DEFF Research Database (Denmark)

    Meyer, Knud Erik

    1998-01-01

    Velocities have been measured with laser Doppler anemometry between tubes in cross-flow in a small in-line tube bundle with longitudinal to transverse pitches of 1.5Dx1.8D and a Reynolds number based on mean velocity in minimum flow section of Re=30000. At most locations a single recirculation zone...

  18. Field validation of protocols developed to evaluate in-line mastitis detection systems

    NARCIS (Netherlands)

    Kamphuis, C.; Dela Rue, B.T.; Eastwood, C.R.

    2016-01-01

    This paper reports on a field validation of previously developed protocols for evaluating the performance of in-line mastitis-detection systems. The protocols outlined 2 requirements of these systems: (1) to detect cows with clinical mastitis (CM) promptly and accurately to enable timely and

  19. Development of a centrifugal in-line separator for oil-water flows

    NARCIS (Netherlands)

    Slot, J.J.

    2013-01-01

    The world energy consumption will increase in the next decades. However, many aging oil fields are showing a steady decline in oil production. And they are producing increasing amounts of water, making the separation of the oil from the oil-water mixture an important processing step. In-line separa

  20. In-line filters in central venous catheters in a neonatal intensive care unit

    NARCIS (Netherlands)

    van den Hoogen, A; Krediet, TG; Uiterwaal, CSPM; Bolenius, JFGA; Gerards, LJ; Fleer, A

    Nosocomial sepsis remains an important cause of morbidity in neonatal intensive care units. Central venous catheters (CVCs) and parenteral nutrition (TPN) are major risk factors. In-line filters in the intravenous (IV) administration sets prevent the infusion of particles, which may reduce

  1. In line NIR quantification of film thickness on pharmaceutical pellets during a fluid bed coating process.

    Science.gov (United States)

    Lee, Min-Jeong; Seo, Da-Young; Lee, Hea-Eun; Wang, In-Chun; Kim, Woo-Sik; Jeong, Myung-Yung; Choi, Guang J

    2011-01-17

    Along with the risk-based approach, process analytical technology (PAT) has emerged as one of the key elements to fully implement QbD (quality-by-design). Near-infrared (NIR) spectroscopy has been extensively applied as an in-line/on-line analytical tool in biomedical and chemical industries. In this study, the film thickness on pharmaceutical pellets was examined for quantification using in-line NIR spectroscopy during a fluid-bed coating process. A precise monitoring of coating thickness and its prediction with a suitable control strategy is crucial to the quality assurance of solid dosage forms including dissolution characteristics. Pellets of a test formulation were manufactured and coated in a fluid-bed by spraying a hydroxypropyl methylcellulose (HPMC) coating solution. NIR spectra were acquired via a fiber-optic probe during the coating process, followed by multivariate analysis utilizing partial least squares (PLS) calibration models. The actual coating thickness of pellets was measured by two separate methods, confocal laser scanning microscopy (CLSM) and laser diffraction particle size analysis (LD-PSA). Both characterization methods gave superb correlation results, and all determination coefficient (R(2)) values exceeded 0.995. In addition, a prediction coating experiment for 70min demonstrated that the end-point can be accurately designated via NIR in-line monitoring with appropriate calibration models. In conclusion, our approach combining in-line NIR monitoring with CLSM and LD-PSA can be applied as an effective PAT tool for fluid-bed pellet coating processes.

  2. Experimental imaging research on continuous-wave terahertz in-line digital holography

    Science.gov (United States)

    Huang, Haochong; Wang, Dayong; Rong, Lu; Wang, Yunxin

    2014-09-01

    The terahertz (THz) imaging is an advanced technique on the basis of the unique characteristics of terahertz radiation. Due to its noncontact, non-invasive and high-resolution capabilities, it has already shown great application prospects in biomedical observation, sample measurement, and quality control. The continuous-wave terahertz in-line digital holography is a combination of terahertz technology and in-line digital holography of which the source is a continuous-wave terahertz laser. Over the past decade, many researchers used different terahertz sources and detectors to undertake experiments. In this paper, the pre-process of the hologram is accomplished after the holograms' recording process because of the negative pixels in the pyroelectric detector and the air vibration caused by the chopper inside the camera. To improve the quality of images, the phase retrieval algorithm is applied to eliminate the twin images. In the experiment, the pin which terahertz wave can't penetrate and the TPX slice carved letters "THz" are chosen for the samples. The amplitude and phase images of samples are obtained and the twin image and noise in the reconstructed images are suppressed. The results validate the feasibility of the terahertz in-line digital holographic imaging technique. This work also shows the terahertz in-line digital holography technique's prospects in materials science and biological samples' detection.

  3. In-line filters in central venous catheters in a neonatal intensive care unit

    NARCIS (Netherlands)

    van den Hoogen, A; Krediet, TG; Uiterwaal, CSPM; Bolenius, JFGA; Gerards, LJ; Fleer, A

    2006-01-01

    Nosocomial sepsis remains an important cause of morbidity in neonatal intensive care units. Central venous catheters (CVCs) and parenteral nutrition (TPN) are major risk factors. In-line filters in the intravenous (IV) administration sets prevent the infusion of particles, which may reduce infectiou

  4. Validation of in-line surface characterization by light scattering in Robot Assisted Polishing

    DEFF Research Database (Denmark)

    Pilny, Lukas; Bissacco, Giuliano; De Chiffre, Leonardo

    2014-01-01

    The suitability of a commercial scattered light sensor for in-line characterization of fine surfaces in the roughness range Sa 1 – 30 nm generated by the Robot Assisted Polishing (RAP) was investigated and validated. A number of surfaces were generated and directly measured with the scattered lig...

  5. In-line holography for flow and cavitation visualization on hydrofoils and for nuclei measurements

    NARCIS (Netherlands)

    Renesse, R.L. van; Meulen, J.H.J. van der

    1980-01-01

    The boundary layer flow about two hydrofoils and the appearance of cavitation are investigated by means of in-line holography. Practical details on the hologram resolution and data collection time for nuclei size analysis are given. It is shown that the appearance of cavitation on the hydrofoils is

  6. MicroRNA与妇科肿瘤%MicroRNA and gynecological oncology

    Institute of Scientific and Technical Information of China (English)

    樊秦娥; 吴立兵

    2014-01-01

    小分子 RNA(microRNA)的发现是分子生物学史上的又一个里程碑。microRNA是一组单链非编码的RNA,由19~25个核苷酸(平均22个核苷酸)组成。研究证实microRNA在生理及病理状态下调节转录后的基因表达。其调节功能与细胞周期的调节,细胞增殖分化,炎症反应及凋亡相关。在许多病理状态下观察到 microRNA表达谱的改变,如糖尿病,类风湿性关节炎以及一些癌症。本综述对microRNA与妇科肿瘤的相关文献进行复习,总结microRNA在妇科肿瘤的发病机制中的可能作用,讨论microRNA作为妇科肿瘤早期诊断和治疗监控的肿瘤标记物的可能性,并对microRNAs在妇科肿瘤中作为治疗靶点和预后判断因素的可能性进行讨论。%The discovery of MicroRNA is another milestone in the history of molecular biology. MicroRNA is a group of single noncoding RNA that consists of 19-25 nucleotides (an average of 22 nucleotides). Study has verified that MicroRNA in physiological and pathological state regulates the transcription of gene expression. Its regulating function is related with regulation of cell cycle, cell proliferation differentiation, inflammation, and apoptosis. In many pathological conditions such as diabetes, rheumatoid arthritis and some cancers, MicroRNA expression changes. This abstract reviewed the pertinent literature of MicroRNA and gynecological tumor, summarized the possible role of MicroRNA in the pathogenesis of gynecological tumors, discussed the possibility of MicroRNA acting as tumor markers in early diagnosis and supervisory treatment and discussed the the possibility of MicroRNA acting as therapeutic targets and the prognostic factors in gynecological tumors .

  7. microPIR: an integrated database of microRNA target sites within human promoter sequences.

    Directory of Open Access Journals (Sweden)

    Jittima Piriyapongsa

    Full Text Available BACKGROUND: microRNAs are generally understood to regulate gene expression through binding to target sequences within 3'-UTRs of mRNAs. Therefore, computational prediction of target sites is usually restricted to these gene regions. Recent experimental studies though have suggested that microRNAs may alternatively modulate gene expression by interacting with promoters. A database of potential microRNA target sites in promoters would stimulate research in this field leading to more understanding of complex microRNA regulatory mechanism. METHODOLOGY: We developed a database hosting predicted microRNA target sites located within human promoter sequences and their associated genomic features, called microPIR (microRNA-Promoter Interaction Resource. microRNA seed sequences were used to identify perfect complementary matching sequences in the human promoters and the potential target sites were predicted using the RNAhybrid program. >15 million target sites were identified which are located within 5000 bp upstream of all human genes, on both sense and antisense strands. The experimentally confirmed argonaute (AGO binding sites and EST expression data including the sequence conservation across vertebrate species of each predicted target are presented for researchers to appraise the quality of predicted target sites. The microPIR database integrates various annotated genomic sequence databases, e.g. repetitive elements, transcription factor binding sites, CpG islands, and SNPs, offering users the facility to extensively explore relationships among target sites and other genomic features. Furthermore, functional information of target genes including gene ontologies, KEGG pathways, and OMIM associations are provided. The built-in genome browser of microPIR provides a comprehensive view of multidimensional genomic data. Finally, microPIR incorporates a PCR primer design module to facilitate experimental validation. CONCLUSIONS: The proposed micro

  8. Spatial inhomogeneity in spectra and exciton dynamics in porphyrin micro-rods and micro-brushes: Confocal microscopy

    Indian Academy of Sciences (India)

    SHYAMTANU CHATTORAJ; KANKAN BHATTACHARYYA

    2016-11-01

    In an aqueous acidic solution, the porphyrin meso-tetra(4-sulfonatophenyl) porphyrin tetrasodium salt (TPPS) forms different kinds of assembly (micro-rods and micro-brush) depending on condition of evaporation. The exciton dynamics and emission spectra of the micro-rods and micro-brushes depend on spatialinhomogeneity. This is elucidated by time-resolved confocal microscopy.

  9. Functional MicroRNA Involved in Endometriosis

    Science.gov (United States)

    Creighton, Chad J.; Han, Derek Y.; Zariff, Azam; Anderson, Matthew L.; Gunaratne, Preethi H.; Matzuk, Martin M.

    2011-01-01

    Endometriosis is a common disease seen by gynecologists. Clinical features involve pelvic pain and unexplained infertility. Although endometriosis is pathologically characterized by endometrial tissue outside the normal uterine location, endometriosis is otherwise not easily explained. Endometriomas, endometriotic cysts of the ovary, typically cause pain and distortion of pelvic anatomy. To begin to understand the pathogenesis of endometriomas, we describe the first transcriptome-microRNAome analysis of endometriomas and eutopic endometrium using next-generation sequencing technology. Using this approach, we generated a total of more than 54 million independent small RNA reads from our 19 clinical samples. At the microRNA level, we found 10 microRNA that were up-regulated (miR-202, 193a-3p, 29c, 708, 509-3-5p, 574-3p, 193a-5p, 485-3p, 100, and 720) and 12 microRNA that were down-regulated (miR-504, 141, 429, 203, 10a, 200b, 873, 200c, 200a, 449b, 375, and 34c-5p) in endometriomas compared with endometrium. Using in silico prediction algorithms, we correlated these microRNA with their corresponding differentially expressed mRNA targets. To validate the functional roles of microRNA, we manipulated levels of miR-29c in an in vitro system of primary cultures of human endometrial stromal fibroblasts. Extracellular matrix genes that were potential targets of miR-29c in silico were significantly down-regulated using this biological in vitro system. In vitro functional studies using luciferase reporter constructs further confirmed that miR-29c directly affects specific extracellular matrix genes that are dysregulated in endometriomas. Thus, miR-29c and other abnormally regulated microRNA appear to play important roles in the pathophysiology of uterine function and dysfunction. PMID:21436257

  10. MicroRNA与黑素瘤%MicroRNA and melanoma

    Institute of Scientific and Technical Information of China (English)

    于少硕; 苏铎

    2013-01-01

    MicroRNA(miRNA)是一种内源性非编码小RNA,在转录后水平负调节靶基因的表达,并参与多种细胞的生命活动,特别是在肿瘤的发生、发展和迁移过程中起重要作用.miRNA通过调控相关靶基因,影响黑素瘤相关蛋白的转录翻译,从而促进或抑制黑素瘤的发生、发展和转移.miR-137和miR-182可以负向调节小眼球相关转录因子(microphthalmia-associatedtranscription factor,MITF)表达,抑制黑素瘤增殖和侵袭;MITF也可以反向调控miR-137和miR-182,增强黑素瘤的迁移能力.miR-221和miR-222通过下调p27Kipl/CDKN1B和c-kit受体两条信号通路促进黑素细胞恶化,从而在黑素瘤中发挥癌基因样效应;而在早幼粒白血病锌指蛋白(promyelocytic leukemia Zinc-Finger,PLZF)结合miR-221和miR-222的调节区后,可以抑制黑素瘤细胞转化和侵袭.Let-7家族成员主要抑制黑素瘤发生、发展和迁移,一旦缺失或表达下降则促进黑素瘤增殖发展.miR-34通过下调原癌基因和相关细胞周期蛋白表达,在黑素瘤中主要发挥抑癌基因样作用.通过检测正常个体和黑素瘤患者外周血miRNA表达谱的差异,有助于诊断黑素瘤;监测分析相关miRNA变化有助于判断患者的疗效和预后情况.因此,深入探索相关miRNA在黑素瘤中的靶基因及调控作用机制有望为黑素瘤的诊断、治疗开辟新途径.

  11. Micro-Grooving and Micro-Threading Tools for Fabricating Curvilinear Features

    Energy Technology Data Exchange (ETDEWEB)

    ADAMS,DAVID P.; VASILE,MICHAEL J.; KRISHNAN,A.S.M.

    2000-07-24

    This paper presents techniques for fabricating microscopic, curvilinear features in a variety of workpiece materials. Micro-grooving and micro-threading tools having cutting widths as small as 13 {micro}m are made by focused ion beam sputtering and used for ultra-precision machining. Tool fabrication involves directing a 20 keV gallium beam at polished cylindrical punches made of cobalt M42 high-speed steel or C2 tungsten carbide to create a number of critically aligned facets. Sputtering produces rake facets of desired angle and cutting edges having radii of curvature equal to 0.4 {micro}m. Clearance for minimizing frictional drag of a tool results from a particular ion beam/target geometry that accounts for the sputter yield dependence on incidence angle. It is believed that geometrically specific cutting tools of this dimension have not been made previously. Numerically controlled, ultra-precision machining with micro-grooving tools results in a close match between tool width and feature size. Microtools are used to machine 13 {micro}m wide, 4 {micro}m deep, helical grooves in polymethyl methacrylate and 6061 Al cylindrical workplaces. Micro-grooving tools are also used to fabricate sinusoidal cross-section features in planar metal samples.

  12. Fabrication of Biochips with Micro Fluidic Channels by Micro End-milling and Powder Blasting

    Directory of Open Access Journals (Sweden)

    Dong Sam Park

    2008-02-01

    Full Text Available For microfabrications of biochips with micro fluidic channels, a large number of microfabrication techniques based on silicon or glass-based Micro-Electro-Mechanical System (MEMS technologies were proposed in the last decade. In recent years, for low cost and mass production, polymer-based microfabrication techniques by microinjection molding and micro hot embossing have been proposed. These techniques, which require a proper photoresist, mask, UV light exposure, developing, and electroplating as a preprocess, are considered to have some problems. In this study, we propose a new microfabrication technology which consists of micro end-milling and powder blasting. This technique could be directly applied to fabricate the metal mold without any preprocesses. The metal mold with micro-channels is machined by micro end-milling, and then, burrs generated in the end-milling process are removed by powder blasting. From the experimental results, micro end-milling combined with powder blasting could be applied effectively for fabrication of the injection mold of biochips with micro fluidic channels.

  13. MicroRNA in 2012: Biotherapeutic potential of microRNAs in rheumatic diseases.

    Science.gov (United States)

    Pers, Yves-Marie; Jorgensen, Christian

    2013-02-01

    A number of microRNAs have been implicated in the pathogenesis of various rheumatic diseases, and evidence in support of the therapeutic potential of microRNA-based strategies for these conditions is growing, as demonstrated by several new findings published in 2012.

  14. MicroRNA与心血管重构%MicroRNA and cardiovascular remodeling

    Institute of Scientific and Technical Information of China (English)

    邓璧

    2013-01-01

    MicroRNA is a short (18-25 nuucleotides) and single-stranded non-coding RNA which is involved in almost all pathological and physiological process of diseases.Cardiovascular remodeling is the pathological basis of development of multiple cardiovascular diseases,in which microRNA plays an important role.In cardiac diseases,microRNAs affect myocardial cell hypertrophy,apoptosis,and interstitial fibrosis through a variety of mechanisms.In vascular remodeling diseases,microRNAs regulate proliferation and secretion of vascular smooth muscle cells through multiple signaling pathways.%MicroRNA为短小(18~25个核苷酸组成)单链非编码RNAs,几乎参与所有疾病的病理生理过程.心血管重构是多种心血管疾病发生与发展的病理基础,而microRNA在心血管重构中起重要调控作用.在心肌性疾病中,microRNA通过多种机制影响心肌细胞肥大、凋亡和间质纤维化;在血管重构性疾病中,不同microRNA通过多条信号通路调节血管平滑肌细胞增殖和分泌.

  15. Micro Engineering: Experiments conducted on the use of polymeric materials in micro injection moulding

    DEFF Research Database (Denmark)

    Griffiths, Christian; Tosello, Guido; Nestler, Joerg

    2008-01-01

    To advance micro injection moulding it is necessary to study systematically the factors affecting process and tooling reliability. This paper reviews the main findings of Cardiff Universities 4M and SEMOFS research in this field. In particular, the factors affecting the manufacturability of micro...

  16. Concept of subsurface micro-sensing; Chika joho no micro sensing

    Energy Technology Data Exchange (ETDEWEB)

    Niitsuma, H. [Tohoku University, Sendai (Japan). Faculty of Engineering

    1997-05-27

    This paper describes concept of subsurface micro-sensing. It is intended to achieve an epoch-making development of subsurface engineerings by developing such technologies as micro measurement of well interior, micro measurement while drilling (MWD), and micro intelligent logging. These technologies are supported by development of micro sensors and micro drilling techniques using micro machine technologies. Micronizing the subsurface sensors makes mass production of sensors with equivalent performance possible, and the production cost can be reduced largely. The sensors can be embedded or used disposably, resulting in increased mobility in measurement and higher performance. Installing multiple number of sensors makes high-accuracy measurement possible, such as array measurement. The sensors can be linked easily with photo-electronics components, realizing remote measurement at low price and high accuracy. Control in micro-drilling and MWD also become possible. Such advantages may also be expected as installing the sensors on the outer side of wells in use and monitoring subsurface information during production. Expectation on them is large as a new paradigm of underground exploration and measurement. 1 fig.

  17. Role of microRNA in Lung Cancer%microRNA在肺癌中的作用

    Institute of Scientific and Technical Information of China (English)

    杨凡; 陈艳; 伍治平; 朱启顺

    2011-01-01

    microRNA是一类长约19~25个核苷酸的非编码小分子.研究表明microRNA 在肿瘤的病理生理过程中发挥着重要作用.全文就microRNA的特征、生物学功能、与 肺癌相关的microRNA及microRNA的检测方法等方面作一综述.

  18. Polymeric Micro-channel-based Functionalisation System for Micro-Cantilevers

    DEFF Research Database (Denmark)

    Nordström, Maria; Gomez, Montserrat; Boisen, Anja

    2005-01-01

    A micro-channel system intended for functionalising micro-cantilevers used for biochemical detection has been designed, realised and characterised. The chip is fabricated in the resist SU-8, which is a photosensitive polymer offering a fast, cost-efficient and easy processing. Cantilevers present...... a new platform for biochemical detection with a high sensitivity. This micro-channel system is used for treating such a cantilever array with probe molecules prior to detection and it can also be used as the analysis set-up. The design of the micro-channel system provides a simple way of coating...... separate sections of a cantilever array with different probe molecules. The use of this channel system eliminates the time-consuming step of addressing each cantilever individually to obtain an array functionalised with different probe molecules. Using this micro-channel system in combination...

  19. Fabrication of micro-alginate gel tubes utilizing micro-gelatin fibers

    Science.gov (United States)

    Sakaguchi, Katsuhisa; Arai, Takafumi; Shimizu, Tatsuya; Umezu, Shinjiro

    2017-05-01

    Tissues engineered utilizing biofabrication techniques have recently been the focus of much attention, because these bioengineered tissues have great potential to improve the quality of life of patients with various hard-to-treat diseases. Most tissues contain micro-tubular structures including blood vessels, lymphatic vessels, and bile canaliculus. Therefore, we bioengineered a micro diameter tube using alginate gel to coat the core gelatin gel. Micro-gelatin fibers were fabricated by the coacervation method and then coated with a very thin alginate gel layer by dipping. A micro diameter alginate tube was produced by dissolving the core gelatin gel. Consequently, these procedures led to the formation of micro-alginate gel tubes of various shapes and sizes. This biofabrication technique should contribute to tissue engineering research fields.

  20. A new micro scale FE model of crystalline materials in micro forming process

    Directory of Open Access Journals (Sweden)

    Luo Liang

    2016-01-01

    Full Text Available Micro forming of metals has drawn global attention due to the increasing requirement of micro metal products. However, the size effects become significant in micro forming processes and affect the application of finite element (FE simulation of micro forming processes. Dividing samples into small areas according to their microstructures and assigning individual properties to each small area are a possible access to micro forming simulation considering material size effects. In this study, a new model that includes both grains and their boundaries was developed based on the observed microstructures of samples. The divided subareas in the model have exact shapes and sizes with real crystals on the sample, and each grain and grain boundaries have their own properties. Moreover, two modelling methods using different information from the microstructural images were introduced in detail. The two modelling methods largely increase the availability of various microstructural images. The new model provides accurate results which present the size effects well.

  1. Micro Groove for Trapping of Flowing Cell

    Directory of Open Access Journals (Sweden)

    Yusuke Takahashi

    2015-06-01

    Full Text Available Micro grooves have been designed to trap a biological cell, which flows through a micro channel in vitro. Each micro groove of a rectangular shape (0.002 mm depth, 0.025 mm width and 0.2 mm length has been fabricated on the surface of the polydimethylsiloxane (PDMS disk with the photolithography technique. Variation has been made on the angle between the longitudinal direction of the groove and the flow direction: zero, 0.79, or 1.57 rad. A rectangular flow channel (0.1 mm depth x 5 mm width x 30 mm length has been constructed with a silicone film of 0.1 mm thick, which has been sandwiched by two transparent PDMS disks. Two types of biological cells were used in the test alternatively: C2C12 (mouse myoblast cell line originated with cross-striated muscle of C3H mouse, or 3T3-L1 (mouse fat precursor cells. A constant flow (2.8 x 10-11 m3/s of a suspension of cells was introduced with a syringe pump. The behavior of cells moving over the micro grooves was observed with an inverted phase contrast microscope. The results show that the cell is trapped with the micro grooves under the wall shear rate of 3 s-1 for a few seconds and that the trapped interval depends on the kind of cells.

  2. Micro-bubbles seeding for flow characterization

    Science.gov (United States)

    Aumelas, V.; Lecoffre, Y.; Maj, G.; Franc, J.-P.

    2016-11-01

    Micro-bubbles injection has long been used in hydrodynamic facilities for the control of dissolved and free air. In some cavitation tunnels [9], very large quantities of microbubbles (billions per second) are injected for rapid degassing and, in smaller quantities (millions per second), for cavitation nuclei seeding. Micro-bubbles can also be used as tracers for optical measurements including visualization, LDV or PIV. For these applications, bubbles must be sufficiently small to faithfully follow the flow. Depending on the quality and spatial characteristics of the micro-bubbles seeding, several optical methods can be applied: simple visualization gives access to semi-quantitative information on the behaviour of flows; LASER velocimetry provides information on the mean velocity and other temporal local characteristics of the flow. This paper presents some new micro-bubbles seeding devices recently developed by YLEC Consultants. These devices have been designed to fulfill specific requirements related to integration into cavitation tunnels and permit optical velocimetry measurement techniques such as Particle Image Velocimetry (PIV). The LEGI cavitation tunnel is the first tunnel which has been equipped with these microbubbles seeding systems dedicated to optical velocimetry. This paper presents the final integration schemes selected for micro-bubbles seeding into LEGI tunnel and discuss about practical concerns related to the use of the injection system for optical velocimetry.

  3. Wideband radar micro-doppler applications

    Science.gov (United States)

    Tahmoush, Dave

    2013-05-01

    Wideband radar provides a significant improvement over traditional narrowband radars for micro-Doppler analysis because the high bandwidth can be used to separate many of the signals in range, allowing a simpler decomposition of the micro-Doppler signals. Recent wideband radar work has focused on micro-Doppler, but there is a point where the narrowband approach used to analyze the micro-Doppler signals breaks down. The effect is shown to be independent of frequency, but the error relative to the bandwidth is shown to be inversely proportional to the frequency and proportional to the velocity of the subject. This error can create a smearing effect in the observed Doppler if it is not corrected, leading to reduced signal-to-noise and the appearance of more diffuse targets in Doppler space. In range-space, wideband data can also break the subject into several range bins, affecting the observed signal to noise ratio. The possible applications of wideband micro-Doppler radar are also shown, including the separation of arm movement from human motion which implies that the arms are not encumbered.

  4. Behavior of Cell on Vibrating Micro Ridges

    Directory of Open Access Journals (Sweden)

    Haruka Hino

    2015-06-01

    Full Text Available The effect of micro ridges on cells cultured at a vibrating scaffold has been studied in vitro. Several parallel lines of micro ridges have been made on a disk of transparent polydimethylsiloxane for a scaffold. To apply the vibration on the cultured cells, a piezoelectric element was attached on the outside surface of the bottom of the scaffold. The piezoelectric element was vibrated by the sinusoidal alternating voltage (Vp-p < 16 V at 1.0 MHz generated by a function generator. Four kinds of cells were used in the test: L929 (fibroblast connective tissue of C3H mouse, Hepa1-6 (mouse hepatoma, C2C12 (mouse myoblast, 3T3-L1 (mouse fat precursor cells. The cells were seeded on the micro pattern at the density of 2000 cells/cm2 in the medium containing 10% FBS (fetal bovine serum and 1% penicillin/ streptomycin. After the adhesion of cells in several hours, the cells are exposed to the ultrasonic vibration for several hours. The cells were observed with a phase contrast microscope. The experimental results show that the cells adhere, deform and migrate on the scaffold with micro patterns regardless of the ultrasonic vibration. The effects of the vibration and the micro pattern depend on the kind of cells.

  5. Advances in micro-perforated panel absorbers

    Institute of Scientific and Technical Information of China (English)

    LIU Ke; TIAN Jing; JIAO Fenglei; L(U) Yadong

    2006-01-01

    Theoretical and experimental investigations on the performance of micro-perforated-panel absorbers are reviewed in this paper. By reviewing recent research work, this paper reveals a relationship between the maximum absorption coefficient and the limit of the absorption frequency bandwidth. It has been demonstrated that the absorption frequency bandwidth can be extended up to 3 or 4 octaves as the diameters of the micro-holes decrease. This has become possible with the development of the technologies for manufacturing micro-perforated panels,such as laser drilling, powder metallurgy, welded meshing and electro-etching to form micrometer order holes. In this paper, absorption characteristics of such absorbers in random fields and in high sound intensity are discussed both theoretically and experimentally. A new absorbing structure based on micro-perforated-panel absorbers demonstrate experimentally high sound absorption capability. This review shows that the micro-perforated-panel absorber has potentials to be one of ideal absorbing materials in the 21st century.

  6. Micro-Expression Recognition Using Color Spaces.

    Science.gov (United States)

    Wang, Su-Jing; Yan, Wen-Jing; Li, Xiaobai; Zhao, Guoying; Zhou, Chun-Guang; Fu, Xiaolan; Yang, Minghao; Tao, Jianhua

    2015-12-01

    Micro-expressions are brief involuntary facial expressions that reveal genuine emotions and, thus, help detect lies. Because of their many promising applications, they have attracted the attention of researchers from various fields. Recent research reveals that two perceptual color spaces (CIELab and CIELuv) provide useful information for expression recognition. This paper is an extended version of our International Conference on Pattern Recognition paper, in which we propose a novel color space model, tensor independent color space (TICS), to help recognize micro-expressions. In this paper, we further show that CIELab and CIELuv are also helpful in recognizing micro-expressions, and we indicate why these three color spaces achieve better performance. A micro-expression color video clip is treated as a fourth-order tensor, i.e., a four-dimension array. The first two dimensions are the spatial information, the third is the temporal information, and the fourth is the color information. We transform the fourth dimension from RGB into TICS, in which the color components are as independent as possible. The combination of dynamic texture and independent color components achieves a higher accuracy than does that of RGB. In addition, we define a set of regions of interests (ROIs) based on the facial action coding system and calculated the dynamic texture histograms for each ROI. Experiments are conducted on two micro-expression databases, CASME and CASME 2, and the results show that the performances for TICS, CIELab, and CIELuv are better than those for RGB or gray.

  7. MICRO ELECTRICAL DISCHARGE MACHINING DEPOSITION IN AIR

    Institute of Scientific and Technical Information of China (English)

    JIN Baidong; ZHAO Wansheng; WANG Zhenlong; CAO Guohui

    2006-01-01

    A new deposition method is described using micro electrical discharge machining (EDM)to deposit tool electrode material on workpiece in air. The basic principles of micro electrical discharge deposition (EDD) are analyzed and the realized conditions are predicted. With an ordinary EDM shaping machine, brass as the electrode, high-speed steel as the workpiece, a lot of experiments are carried out on micro EDD systematically and thoroughly. The effects of major processing parameters, such as the discharge current, discharge duration, pulse interval and working medium, are obtained. As a result, a micro cylinder with 0.19 mm in diameter and 7.35 mm in height is deposited.By exchanging the polarities of the electrode and workpiece the micro cylinder can be removed selectively. So the reversible machining of deposition and removal is achieved, which breaks through the constraint of traditional EDM. Measurements show that the deposited material is compact and close to workpiece base, whose components depend on the tool electrode material.

  8. In-line high-rate evaporation of aluminum for the metallization of silicon solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Mader, Christoph Paul

    2012-07-11

    This work focuses on the in-line high-rate evaporation of aluminum for contacting rear sides of silicon solar cells. The substrate temperature during the deposition process, the wafer bow after deposition, and the electrical properties of evaporated contacts are investigated. Furthermore, this work demonstrates for the first time the formation of aluminum-doped silicon regions by the in-line high-rate evaporation of aluminum without any further temperature treatment. The temperature of silicon wafers during in-line high-rate evaporation of aluminum is investigated in this work. The temperatures are found to depend on the wafer thickness W, the aluminum layer thickness d, and on the wafer emissivity {epsilon}. Two-dimensional finite-element simulations reproduce the measured peak temperatures with an accuracy of 97%. This work also investigates the wafer bow after in-line high-rate evaporation and shows that the elastic theory overestimates the wafer bow of planar Si wafers. The lower bow is explained with plastic deformation in the Al layer. Due to the plastic deformation only the first 79 K in temperature decrease result in a bow formation. Furthermore the electrical properties of evaporated point contacts are examined in this work. Parameterizations for the measured saturation currents of contacted p-type Si wafers and of contacted boron-diffused p{sup +}-type layers are presented. The contact resistivity of the deposited Al layers to silicon for various deposition processes and silicon surface concentrations are presented and the activation energy of the contact formation is determined. The measured saturation current densities and contact resistivities of the evaporated contacts are used in one-dimensional numerical Simulations and the impact on energy conversion efficiency of replacing a screen-printed rear side by an evaporated rear side is presented. For the first time the formation of aluminum-doped p{sup +}-type (Al-p{sup +}) silicon regions by the in-line

  9. Comparative Study for Improving the Thermal and Fluid Flow Performance of Micro Channel Fin Geometries Using Numerical Simulation

    Directory of Open Access Journals (Sweden)

    S.Subramanian

    2015-07-01

    Full Text Available There is a continuous quest for improving the performance of micro channels for handling the increased dissipation of heat from electronics circuits. The Oblique fin micro channels are attractive as they perform better than plate fin & pin fin configurations. There are scopes for further improvements in oblique fin micro channels. Hence this work is about the investigation for the performance enhancement by modifying the oblique fin geometry. Seven variants of micro channel geometries have been explored using three dimensional numerical simulations. The variants are plate fin, in-line pin fin, staggered pin fin, oblique fin, oblique fin with two slit angles, oblique with nozzle type slit and improved oblique fin. The simulation results are validated using the published data. To ensure a common reference for comparison, hydraulic diameter, inlet flow conditions, heat loads and the boundary conditions are kept identical across all the geometries. The results of simulation are compared for the thermal & fluid flow performances. Heat transfer correlations have been developed using the simulation data. The proposed modification is found to enhance the performance significantly

  10. Micro-nanorobotic manipulation systems and their applications

    CERN Document Server

    Fukuda, Toshio; Nakajima, Masahiro

    2013-01-01

    Micro/Nano Robotics and Automation technologies have rapidly grown associated with the growth of Micro and Nanotechnologies. This book presents a summary of fundamentals in micro-nano scale engineering and the current state of the art of these technologies. “Micro-Nanorobotic Manipulation Systems and their Applications” introduces these advanced technologies from the basics and applications aspects of Micro/Nano-Robotics and Automation from the prospective micro/nano-scale manipulation. The book is organized in 9 chapters including an overview chapter of Micro/Nanorobotics and Automation technology from the historical view and important related research works. Further chapters are devoted to the physics of micro-nano fields as well as to material and science, microscopes, fabrication technology, importance of biological cell, and control techniques. Furthermore important examples, applications and a concise summary of Micro-Nanorobotics and Automation technologies are given.    

  11. Micro Products - Product Development and Design

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard

    2003-01-01

    -disciplinary competences. One example is sensors for chemical analysis of fluids, where chemistry, biology and flow mechanics all influence the design of the product and thereby the industrial fabrication of the product [1]. On the technological side the development has moved very fast, primarily driven by the need...... of the electronics industry to create still smaller chips with still larger capacity. Therefore the manufacturing technologies connected with micro/nano products in silicon are relatively highly developed compared to the technologies used for manufacturing micro products in metals, polymers and ceramics. For all...... technologies, however, it is a continuously increasing challenge to create the operational basis for an industrial production of micro products. As the products through product development processes are made applicable to a large number of customers, the pressure in regard to developing production technologies...

  12. Injection moulding for macro and micro products

    DEFF Research Database (Denmark)

    Islam, Mohammad Aminul

    The purpose of the literature survey is to investigate the injection moulding technology in the macro and micro areas from the basic to the state-of-the-art recent technology. Injection moulding is a versatile production process for the manufacturing of plastic parts and the process is extensively...... used for macro products but with the ages it is going deep into the micro areas having machine and process improvements. Extensive research work on injection moulding is going on all over the world. New ideas are flowing into the machines, materials and processes. The technology has made significant...... advancement in the area of micro injection moulding, multi-component and two component injection mounding. In near future it is likely to be the way of manufacturing moulded interconnects devices (MID) for a low cost integration of electrical and mechanical functionalities on a single device. This paper...

  13. Micro-CHP Systems for Residential Applications

    Energy Technology Data Exchange (ETDEWEB)

    Timothy DeValve; Benoit Olsommer

    2007-09-30

    Integrated micro-CHP (Cooling, Heating and Power) system solutions represent an opportunity to address all of the following requirements at once: conservation of scarce energy resources, moderation of pollutant release into our environment, and assured comfort for home-owners. The objective of this effort was to establish strategies for development, demonstration, and sustainable commercialization of cost-effective integrated CHP systems for residential applications. A unified approach to market and opportunity identification, technology assessment, specific system designs, adaptation to modular product platform component conceptual designs was employed. UTRC's recommendation to U.S. Department of Energy is to go ahead with the execution of the proposed product development and commercialization strategy plan under Phase II of this effort. Recent indicators show the emergence of micro-CHP. More than 12,000 micro-CHP systems have been sold worldwide so far, around 7,500 in 2004. Market projections predict a world-wide market growth over 35% per year. In 2004 the installations were mainly in Europe (73.5%) and in Japan (26.4%). The market in North-America is almost non-existent (0.1%). High energy consumption, high energy expenditure, large spark-spread (i.e., difference between electricity and fuel costs), big square footage, and high income are the key conditions for market acceptance. Today, these conditions are best found in the states of New York, Pennsylvania, New Jersey, Wisconsin, Illinois, Indiana, Michigan, Ohio, New England states. A multiple stage development plan is proposed to address risk mitigation. These stages include concept development and supplier engagement, component development, system integration, system demonstration, and field trials. A two stage commercialization strategy is suggested based on two product versions. The first version--a heat and power system named Micro-Cogen, provides the heat and essential electrical power to the

  14. MicroRNAs, epigenetics and disease

    DEFF Research Database (Denmark)

    Silahtaroglu, Asli; Stenvang, Jan

    2010-01-01

    Epigenetics is defined as the heritable chances that affect gene expression without changing the DNA sequence. Epigenetic regulation of gene expression can be through different mechanisms such as DNA methylation, histone modifications and nucleosome positioning. MicroRNAs are short RNA molecules...... which do not code for a protein but have a role in post-transcriptional silencing of multiple target genes by binding to their 3' UTRs (untranslated regions). Both epigenetic mechanisms, such as DNA methylation and histone modifications, and the microRNAs are crucial for normal differentiation...... diseases. In the present chapter we will mainly focus on microRNAs and methylation and their implications in human disease, mainly in cancer....

  15. [Surgical treatment of micro-ophthalmic syndromes].

    Science.gov (United States)

    Pellerin, P; Mouriaux, F; Dhellemmes-Defoort, S; Guilbert, F

    1997-10-01

    The complex embryology of the oculo-orbito-palpebral region is responsible for a number of heterogeneous clinicopathological situations, associating variable proportions of the three components of the malformation: micro-anophthalmia, microblepharism, micro-orbitism. Application of the double principle of skin expansion for the eyelids and distraction of the callus for the orbit, as early as possible (first year of life), is possible by means of a device which consists of a combination of an intraorbital expansion balloon, an antireflux valve to avoid effective pressure losses in the balloon, and an injection site for progressive filling of the expansion balloon. The response to these treatments is excellent for cases of simple microphthalmia and micro-orbitism; in complex craniofacial malformations, it generally only partially resolves the problem, but provides a precious complement to the quality of the final repair.

  16. The Aarhus Ion Micro-Trap Project

    DEFF Research Database (Denmark)

    Miroshnychenko, Yevhen; Nielsen, Otto; Poulsen, Gregers

    As part of our involvement in the EU MICROTRAP project, we have designed, manufactured and assembled a micro-scale ion trap with integrated optical fibers. These prealigned fibers will allow delivering cooling laser light to single ions. Therefore, such a trap will not require any direct optical...... access for laser cooling. All the parts for the trap have been made in our institute [1]. The electrodes and the spacers were laser cut in the collaboration with the group of P.  Balling. In our group we have developed a technique to manufacture lensed optical fibers. The trap is now assembled...... and installed in an ultra high vacuum chamber, which includes an ablation oven for all-optical loading of the trap [2]. The next steps on the project are to demonstrate the operation of the micro-trap and the cooling of ions using fiber delivered light. [1] D. Grant, Development of Micro-Scale Ion traps, Master...

  17. Laser based micro forming and assembly.

    Energy Technology Data Exchange (ETDEWEB)

    MacCallum, Danny O' Neill; Wong, Chung-Nin Channy; Knorovsky, Gerald Albert; Steyskal, Michele D.; Lehecka, Tom (Pennsylvania State University, Freeport, PA); Scherzinger, William Mark; Palmer, Jeremy Andrew

    2006-11-01

    It has been shown that thermal energy imparted to a metallic substrate by laser heating induces a transient temperature gradient through the thickness of the sample. In favorable conditions of laser fluence and absorptivity, the resulting inhomogeneous thermal strain leads to a measurable permanent deflection. This project established parameters for laser micro forming of thin materials that are relevant to MESA generation weapon system components and confirmed methods for producing micrometer displacements with repeatable bend direction and magnitude. Precise micro forming vectors were realized through computational finite element analysis (FEA) of laser-induced transient heating that indicated the optimal combination of laser heat input relative to the material being heated and its thermal mass. Precise laser micro forming was demonstrated in two practical manufacturing operations of importance to the DOE complex: micrometer gap adjustments of precious metal alloy contacts and forming of meso scale cones.

  18. MicroRNA and gynecological reproductive diseases.

    Science.gov (United States)

    Santamaria, Xavier; Taylor, Hugh

    2014-06-01

    MicroRNAs (miRNAs) are a class of small non-coding RNAs estimated to regulate the translation of mRNAs in 30% of all genes in animals by inhibiting translation. Aberrant miRNA expression is associated with many human diseases, including gynecological diseases, cancer, inflammatory diseases, and cardiovascular disorders. Abnormal expression of miRNAs has been observed in multiple human reproductive tract diseases including preeclampsia, endometrioid endometrial adenocarcinoma, uterine leiomyomata, ovarian carcinoma, endometriosis, and recurrent pregnancy loss. In the following review, an update of the role of microRNA and gynecological diseases is performed covering, not only impact of microRNA dysregulation in the origin of each disease, but also showing the potential useful diagnostic and therapeutic tool that miRNA may play in these gynecological pathologies.

  19. Micro Gas Turbine – A Review

    Directory of Open Access Journals (Sweden)

    Tushar Shukla

    2013-10-01

    Full Text Available Turbomachines is a class of machines which comprise of turbines and compressors. These machines are widely used for power generation, aircraft propulsion and in a wide range of heavy and medium industries. When we scale down these large turbines, we get micro turbines, which are compact and miniaturized form of these large turbines. The process of scaling down a turbine is not as simple as it looks like, it is a very tedious job and researches are going on in this area. These micro gas turbines are usually found with a power generating capacity of 250kW. They use any gas like natural gas, biogas, etc. as its input. The advantages of a micro gas turbine are that it has high expansion ratio and less moving components. The drawbacks of these turbines are that it requires high angular velocity as well as advanced electronics which can convert electricity of high frequency which gets produced into useful frequency of 50/60 Hz. This turbine is a very viable solution for distributed power generation which can be used for stationary energy applications. Also, micro gas turbine has found great use as cogeneration systems. These micro gas turbines can produce power between less than a kilowatt to hundreds of watts, which can be used for various purposes like electricity generation or head creation. These turbines are cost-effective, eco-friendly and pollution free as they can work by burning any gas like natural gas, land fill gas, etc. The manuscript presented gives an outlook on the past, present and future of these micro gas turbines. This paper will discuss the advantages and its uses. It will also discuss the drawbacks and the limitations of these turbines. This manuscript will prove to be a reference to all the researchers who want work in this field

  20. Dual-channel in-line digital holographic double random phase encryption.

    Science.gov (United States)

    Das, Bhargab; Yelleswarapu, Chandra S; Rao, D V G L N

    2012-10-01

    We present a robust encryption method for the encoding of 2D/3D objects using digital holography and virtual optics. Using our recently developed dual-plane in-line digital holography technique, two in-line digital holograms are recorded at two different planes and are encrypted using two different double random phase encryption configurations, independently. The process of using two mutually exclusive encryption channels makes the system more robust against attacks since both the channels should be decrypted accurately in order to get a recognizable reconstruction. Results show that the reconstructed object is unrecognizable even when the portion of the correct phase keys used during decryption is close to 75%. The system is verified against blind decryptions by evaluating the SNR and MSE. Validation of the proposed method and sensitivities of the associated parameters are quantitatively analyzed and illustrated.